# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- MMR_HSR1 PF01926.18 CDI76016.1 - 7.2e-07 29.1 0.0 0.0012 18.7 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase Med15 PF09606.5 CDI76016.1 - 0.0018 16.5 16.6 0.0018 16.5 11.5 2.5 3 0 0 3 3 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal T2SE PF00437.15 CDI76016.1 - 0.0076 15.1 0.1 0.012 14.5 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.1 CDI76016.1 - 0.009 16.3 9.6 0.24 11.7 0.6 3.0 3 0 0 3 3 3 2 AAA domain MobB PF03205.9 CDI76016.1 - 0.022 14.4 0.0 0.057 13.1 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CDI76016.1 - 0.028 14.4 8.6 1.1 9.2 0.0 3.1 2 1 1 3 3 3 0 AAA ATPase domain FeoB_N PF02421.13 CDI76016.1 - 0.091 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B Peptidase_U57 PF05582.7 CDI76016.1 - 0.7 8.8 4.0 3.9 6.3 1.8 2.0 2 0 0 2 2 2 0 YabG peptidase U57 Ctr PF04145.10 CDI76016.1 - 1.8 8.6 4.0 13 5.8 0.1 2.5 2 0 0 2 2 2 0 Ctr copper transporter family Neur_chan_memb PF02932.11 CDI76016.1 - 2.2 8.0 6.6 13 5.6 0.1 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3947 PF13135.1 CDI76016.1 - 3.3 7.9 16.2 0.11 12.6 5.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) BUD22 PF09073.5 CDI76019.1 - 1.5 7.7 55.2 0.081 11.9 31.4 2.6 2 0 0 2 2 2 0 BUD22 Mpp10 PF04006.7 CDI76019.1 - 2.2 6.5 53.3 0.018 13.4 30.3 2.0 2 0 0 2 2 2 0 Mpp10 protein Daxx PF03344.10 CDI76019.1 - 4 5.7 68.1 0.95 7.8 42.8 2.5 2 0 0 2 2 2 0 Daxx Family DUF4017 PF13209.1 CDI76021.1 - 0.12 12.1 2.8 0.22 11.3 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4017) zf-DHHC PF01529.15 CDI76021.1 - 6.5 6.1 10.7 1.5 8.1 4.2 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase TBP PF00352.16 CDI76023.1 - 6.7e-33 111.9 0.0 1.4e-20 72.4 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 CDI76023.1 - 0.023 14.7 0.2 0.086 12.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) TBPIP PF07106.8 CDI76025.1 - 2.8e-06 26.9 5.2 0.0025 17.4 0.1 2.3 1 1 1 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF2011 PF09428.5 CDI76025.1 - 2.6 7.9 8.6 0.19 11.6 2.5 1.6 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF2011) Etmic-2 PF06670.6 CDI76028.1 - 4.2e-67 226.5 16.3 1.8e-45 155.2 5.6 2.9 1 1 1 2 2 2 2 Microneme protein Etmic-2 Pkinase PF00069.20 CDI76031.1 - 0.0055 15.8 0.0 0.024 13.8 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76031.1 - 0.041 12.9 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase SNF2_N PF00176.18 CDI76033.1 - 3.1e-72 242.9 0.0 4.8e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.1 CDI76033.1 - 1.4e-08 34.6 7.2 3e-08 33.5 5.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI76033.1 - 8.4e-08 31.8 4.2 1.9e-07 30.7 2.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 CDI76033.1 - 1.4e-07 31.2 6.9 3.3e-07 30.0 4.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDI76033.1 - 8e-07 28.6 5.1 1.7e-06 27.5 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI76033.1 - 1.6e-06 27.6 5.8 3.1e-06 26.7 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDI76033.1 - 0.00098 18.9 7.6 0.0021 17.9 5.3 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-MIZ PF02891.15 CDI76033.1 - 0.0014 18.0 5.3 0.0033 16.9 3.7 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Helicase_C PF00271.26 CDI76033.1 - 0.0068 16.2 0.0 0.025 14.4 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.1 CDI76033.1 - 0.008 15.8 3.2 0.02 14.6 2.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.1 CDI76033.1 - 0.051 13.1 2.5 0.13 11.9 1.7 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 CDI76033.1 - 0.27 11.0 3.2 0.57 10.0 2.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Peptidase_C48 PF02902.14 CDI76035.1 - 3e-20 72.7 0.0 8.2e-20 71.3 0.0 1.7 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Ank_5 PF13857.1 CDI76038.1 - 2.7e-07 30.6 0.0 2.2e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI76038.1 - 7.7e-07 29.3 0.0 1.7e-06 28.2 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI76038.1 - 1.3e-05 25.5 0.0 9.3e-05 22.8 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI76038.1 - 1.8e-05 24.5 0.0 0.22 11.8 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 CDI76038.1 - 0.0021 17.7 0.1 1.2 9.0 0.1 3.1 2 1 0 2 2 2 2 Ankyrin repeat CAP_N PF01213.14 CDI76038.1 - 0.53 9.5 2.8 0.43 9.8 0.8 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Peptidase_M24 PF00557.19 CDI76039.1 - 4.1e-32 111.4 0.1 7.3e-32 110.6 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 CDI76039.1 - 4.2e-13 48.8 0.0 7e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain FBPase PF00316.15 CDI76040.1 - 1.1e-60 205.2 0.0 1.4e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 CDI76040.1 - 0.1 11.8 0.0 1.5 8.0 0.0 2.1 2 0 0 2 2 2 0 Inositol monophosphatase family SF-assemblin PF06705.6 CDI76042.1 - 1.2e-40 139.2 20.7 1.5e-40 138.9 14.4 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin PAPA-1 PF04795.7 CDI76042.1 - 0.02 15.5 2.4 0.02 15.5 1.7 2.0 2 1 0 2 2 2 0 PAPA-1-like conserved region DUF4085 PF13315.1 CDI76042.1 - 0.088 12.1 3.0 0.18 11.1 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Baculo_PEP_C PF04513.7 CDI76042.1 - 0.099 12.4 11.6 0.078 12.7 0.4 3.6 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sigma70_ner PF04546.8 CDI76042.1 - 0.59 9.7 11.8 1.2 8.7 1.5 2.6 1 1 1 2 2 2 0 Sigma-70, non-essential region Cid2 PF09774.4 CDI76042.1 - 1.2 9.1 0.1 1.2 9.1 0.0 3.1 2 1 0 3 3 3 0 Caffeine-induced death protein 2 DUF3708 PF12501.3 CDI76042.1 - 2.5 7.9 8.8 2.1 8.1 0.6 2.7 2 1 1 3 3 3 0 Phosphate ATP-binding cassette transporter bZIP_1 PF00170.16 CDI76042.1 - 3.2 7.7 11.1 3.8 7.5 1.0 3.6 4 1 0 4 4 4 0 bZIP transcription factor Peptidase_C50 PF03568.12 CDI76043.1 - 0.00012 20.9 0.0 0.0002 20.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C50 DoxX PF07681.7 CDI76044.1 - 0.2 12.0 1.4 0.85 10.0 0.1 2.6 3 0 0 3 3 3 0 DoxX PSD1 PF07587.6 CDI76045.1 - 0.083 12.2 0.0 0.09 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) Peptidase_S8 PF00082.17 CDI76046.1 - 2.9e-44 151.3 0.7 4.3e-44 150.7 0.5 1.2 1 0 0 1 1 1 1 Subtilase family Cu-binding_MopE PF11617.3 CDI76046.1 - 0.28 10.9 5.2 0.62 9.8 3.6 1.6 1 0 0 1 1 1 0 Protein metal binding site V-SNARE_C PF12352.3 CDI76047.1 - 7e-13 48.4 0.1 7e-13 48.4 0.1 1.7 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 CDI76047.1 - 0.002 17.7 0.0 0.0045 16.6 0.0 1.5 1 0 0 1 1 1 1 Sec20 RRM_1 PF00076.17 CDI76049.1 - 3.2e-09 36.2 0.0 5.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76049.1 - 2.6e-08 33.7 0.0 5.6e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76049.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDI76049.1 - 0.0018 17.9 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF2992 PF11208.3 CDI76050.1 - 0.74 9.7 8.5 1.1 9.2 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Lin-8 PF03353.10 CDI76050.1 - 0.95 8.6 12.1 0.88 8.7 8.1 1.2 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist DnaJ PF00226.26 CDI76051.1 - 7.5e-25 86.4 2.1 1.3e-24 85.6 1.5 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CDI76051.1 - 1.1e-21 76.5 0.1 2e-20 72.4 0.0 2.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CDI76051.1 - 5.1e-13 48.8 16.6 5.1e-13 48.8 11.5 2.1 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.14 CDI76051.1 - 0.014 15.1 10.6 0.16 11.6 0.3 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Tnp_zf-ribbon_2 PF13842.1 CDI76051.1 - 1.9 8.9 9.0 21 5.6 0.1 3.0 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DUF2839 PF10999.3 CDI76053.1 - 3.6 7.7 6.8 23 5.1 0.5 4.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) DNA_mis_repair PF01119.14 CDI76054.1 - 4.7e-27 93.8 0.0 1.1e-26 92.6 0.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 CDI76054.1 - 2e-10 40.4 0.0 1.7e-09 37.4 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDI76054.1 - 2.9e-08 33.4 0.0 6.3e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cwf_Cwc_15 PF04889.7 CDI76054.1 - 0.012 15.3 1.0 0.012 15.3 0.7 5.4 7 0 0 7 7 7 0 Cwf15/Cwc15 cell cycle control protein Proteasome PF00227.21 CDI76055.1 - 1.2e-24 86.6 8.5 4.9e-13 48.7 0.0 3.1 3 1 0 3 3 3 2 Proteasome subunit Polyoma_coat PF00718.15 CDI76055.1 - 0.03 13.2 0.0 0.03 13.2 0.0 2.5 3 0 0 3 3 3 0 Polyomavirus coat protein PAT1 PF09770.4 CDI76055.1 - 0.17 10.1 53.7 0.66 8.1 33.0 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI76055.1 - 0.25 11.1 40.8 2 8.2 0.3 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.5 CDI76055.1 - 0.53 8.4 80.8 0.03 12.5 0.8 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal PhoD PF09423.5 CDI76057.1 - 4e-07 28.9 0.0 6.6e-05 21.6 0.1 2.1 1 1 0 2 2 2 2 PhoD-like phosphatase Med15 PF09606.5 CDI76057.1 - 0.0058 14.9 13.9 0.0089 14.2 9.7 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI76057.1 - 0.025 14.3 0.9 0.025 14.3 0.6 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF236 PF03057.9 CDI76057.1 - 0.12 12.2 5.6 0.23 11.3 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function Ctr PF04145.10 CDI76057.1 - 1.3 9.0 4.8 16 5.4 0.0 2.8 2 1 0 2 2 2 0 Ctr copper transporter family KASH PF10541.4 CDI76057.1 - 2 8.3 19.1 9.5 6.1 0.1 2.5 2 0 0 2 2 2 0 Nuclear envelope localisation domain DUF936 PF06075.7 CDI76058.1 - 6.5 5.5 38.8 8.6 5.1 26.9 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Coatomer_WDAD PF04053.9 CDI76060.1 - 4.1e-75 253.2 0.0 6.5e-44 150.4 0.4 3.3 1 1 2 3 3 3 3 Coatomer WD associated region WD40 PF00400.27 CDI76060.1 - 1.8e-25 87.8 12.6 1.5e-08 34.2 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat Use1 PF09753.4 CDI76060.1 - 0.03 13.7 13.0 0.056 12.8 9.0 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 PAT1 PF09770.4 CDI76060.1 - 1.6 6.8 51.5 2.1 6.4 35.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TAP42 PF04177.7 CDI76061.1 - 4e-30 104.9 1.6 4.2e-18 65.3 0.0 2.1 2 0 0 2 2 2 2 TAP42-like family BAF1_ABF1 PF04684.8 CDI76063.1 - 0.0026 16.6 18.1 0.0026 16.6 12.6 5.5 5 1 0 6 6 6 2 BAF1 / ABF1 chromatin reorganising factor Pex14_N PF04695.8 CDI76063.1 - 0.01 15.8 8.0 0.01 15.8 5.6 4.1 3 1 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BatD PF13584.1 CDI76063.1 - 0.17 10.4 6.1 0.039 12.5 1.1 1.9 2 0 0 2 2 2 0 Oxygen tolerance Plasmodium_Vir PF05795.6 CDI76063.1 - 0.25 10.5 0.5 0.37 9.9 0.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Serinc PF03348.10 CDI76063.1 - 0.49 9.0 4.7 1.3 7.6 3.2 1.7 1 0 0 1 1 1 0 Serine incorporator (Serinc) PAT1 PF09770.4 CDI76063.1 - 2.8 6.0 35.4 0.87 7.7 15.3 3.0 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 AIF_C PF14721.1 CDI76063.1 - 3 8.1 5.9 0.34 11.1 0.5 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Band_3_cyto PF07565.8 CDI76063.1 - 8.4 5.8 11.9 0.43 10.0 3.5 2.2 3 0 0 3 3 3 0 Band 3 cytoplasmic domain Spt20 PF12090.3 CDI76063.1 - 9.6 5.5 17.8 11 5.3 8.0 3.0 3 0 0 3 3 3 0 Spt20 family AP2 PF00847.15 CDI76065.1 - 2.1e-08 34.1 1.2 2.1e-08 34.1 0.8 6.9 8 0 0 8 8 8 1 AP2 domain DOT1 PF08123.8 CDI76068.1 - 0.0002 20.7 0.1 0.00039 19.7 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 PrmA PF06325.8 CDI76068.1 - 0.0032 16.6 1.0 0.0075 15.4 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CRAL_TRIO PF00650.15 CDI76069.1 - 6.5e-05 22.4 0.1 0.00032 20.2 0.0 1.9 1 1 1 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CDI76069.1 - 0.056 13.5 0.1 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain DUF663 PF04950.7 CDI76070.1 - 2e-58 197.7 0.0 6.2e-49 166.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF663) AARP2CN PF08142.7 CDI76070.1 - 1.1e-06 28.0 0.0 5.5e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 AARP2CN (NUC121) domain CCDC66 PF15236.1 CDI76071.1 - 0.0001 21.9 15.1 0.0001 21.9 10.5 2.1 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 66 DUF2777 PF10949.3 CDI76071.1 - 0.052 13.2 1.1 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2777) cEGF PF12662.2 CDI76075.1 - 6.5e-08 32.0 5.2 2.5e-07 30.2 3.6 2.1 1 0 0 1 1 1 1 Complement Clr-like EGF-like Peptidase_C11 PF03415.9 CDI76075.1 - 1e-07 31.3 0.0 4.3e-05 22.6 0.0 2.9 3 0 0 3 3 3 2 Clostripain family Notch PF00066.12 CDI76075.1 - 2.3e-05 24.5 2.1 2.3e-05 24.5 1.4 2.5 3 0 0 3 3 3 1 LNR domain RNase_Zc3h12a PF11977.3 CDI76078.1 - 1.3e-05 25.0 0.0 2.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain WWE PF02825.15 CDI76078.1 - 0.00017 20.8 0.2 0.0011 18.3 0.1 2.3 3 0 0 3 3 3 1 WWE domain CBM_20 PF00686.14 CDI76079.1 - 6.5e-13 48.1 0.0 1.8e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 Starch binding domain Gcd10p PF04189.8 CDI76080.1 - 8.5e-19 67.7 0.0 3.5e-18 65.7 0.0 2.0 1 1 0 1 1 1 1 Gcd10p family ADK PF00406.17 CDI76081.1 - 8.7e-15 54.9 0.6 3.2e-11 43.3 0.4 3.0 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 CDI76081.1 - 4.5e-07 30.7 0.0 6.4e-07 30.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDI76081.1 - 2.3e-06 27.5 0.1 7.2e-06 25.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 CDI76081.1 - 6e-05 22.3 1.0 0.0001 21.6 0.0 1.8 1 1 1 2 2 2 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 CDI76081.1 - 8.5e-05 22.8 0.0 0.00012 22.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 CDI76081.1 - 0.00063 18.9 0.1 0.0012 18.0 0.0 1.5 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 CDI76081.1 - 0.00074 19.5 1.3 0.008 16.1 0.9 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI76081.1 - 0.0028 17.6 0.9 0.0041 17.1 0.6 1.3 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 CDI76081.1 - 0.0061 15.6 0.0 0.0087 15.1 0.0 1.3 1 1 0 1 1 1 1 Zeta toxin TRP PF06011.7 CDI76081.1 - 0.032 12.8 0.0 0.032 12.8 0.0 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel CPT PF07931.7 CDI76081.1 - 0.08 12.5 0.0 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Topoisom_I_N PF02919.10 CDI76083.1 - 3.2e-29 101.7 0.1 1.3e-22 80.2 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic DNA topoisomerase I, DNA binding fragment HJURP_C PF12347.3 CDI76083.1 - 0.11 12.1 0.1 0.33 10.5 0.1 1.8 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat DUF755 PF05501.6 CDI76083.1 - 2.8 7.9 15.0 6.1 6.9 10.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF572 PF04502.8 CDI76083.1 - 6.2 5.9 12.9 10 5.1 9.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2453 PF10507.4 CDI76084.1 - 2.5e-12 46.5 0.3 2.5e-12 46.5 0.2 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2453) EF-hand_5 PF13202.1 CDI76084.1 - 1.4e-05 24.1 0.0 2.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 CDI76084.1 - 4.5e-05 23.5 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI76084.1 - 0.00026 20.0 0.0 0.00063 18.8 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 CDI76084.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain Usp PF00582.21 CDI76084.1 - 0.38 10.9 2.7 11 6.2 0.1 2.8 3 0 0 3 3 3 0 Universal stress protein family DUF3395 PF11875.3 CDI76085.1 - 1.4e-21 76.7 4.6 5.6e-19 68.2 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3395) DnaJ PF00226.26 CDI76085.1 - 1.8e-17 62.7 0.0 3.8e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DUF1703 PF08011.6 CDI76085.1 - 0.25 11.0 2.3 0.62 9.8 1.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1703) APG6 PF04111.7 CDI76085.1 - 1.5 7.8 6.5 2.1 7.2 4.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 U3_assoc_6 PF08640.6 CDI76086.1 - 3.3e-11 42.7 4.1 3.3e-11 42.7 2.8 2.6 2 1 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 DUF4207 PF13904.1 CDI76086.1 - 0.0046 16.3 21.6 0.0046 16.3 15.0 8.4 7 3 0 7 7 7 1 Domain of unknown function (DUF4207) CHZ PF09649.5 CDI76087.1 - 2.6e-05 23.3 1.2 2.6e-05 23.3 0.8 2.8 3 0 0 3 3 3 1 Histone chaperone domain CHZ GRAS PF03514.9 CDI76087.1 - 1.3 7.6 6.4 0.3 9.7 2.3 1.5 2 0 0 2 2 2 0 GRAS domain family Phyto_Pns9_10 PF05878.6 CDI76087.1 - 8.5 5.2 12.2 18 4.2 8.5 1.7 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Herpes_gE PF02480.11 CDI76089.1 - 0.059 11.6 0.8 0.16 10.1 0.0 1.9 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E SR-25 PF10500.4 CDI76089.1 - 2 7.8 16.2 6.1 6.2 11.2 1.9 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAD_binding_2 PF00890.19 CDI76092.1 - 1.4e-53 182.3 9.1 5.1e-27 94.7 0.0 3.3 1 1 2 3 3 3 3 FAD binding domain Succ_DH_flav_C PF02910.15 CDI76092.1 - 1.7e-24 86.0 1.2 1.7e-24 86.0 0.8 1.7 2 0 0 2 2 2 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 CDI76092.1 - 0.00024 21.0 3.9 0.00047 20.1 0.5 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI76092.1 - 0.0012 18.0 0.1 0.0023 17.0 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 CDI76092.1 - 0.003 16.6 0.4 0.0056 15.7 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CDI76092.1 - 0.0088 14.9 0.2 0.0088 14.9 0.1 2.5 2 1 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.17 CDI76092.1 - 0.015 14.1 2.1 0.015 14.1 1.4 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A DEAD PF00270.24 CDI76095.1 - 2e-13 50.1 0.7 3e-13 49.5 0.5 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF3747 PF12565.3 CDI76095.1 - 4.5 6.3 5.8 0.38 9.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3747) Gly-zipper_OmpA PF13436.1 CDI76097.1 - 0.02 14.5 7.5 0.077 12.6 5.2 2.1 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Pox_A_type_inc PF04508.7 CDI76097.1 - 0.033 13.9 0.4 0.033 13.9 0.3 5.3 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat TmoB PF06234.7 CDI76097.1 - 0.041 13.7 1.6 0.097 12.5 0.0 2.4 3 0 0 3 3 3 0 Toluene-4-monooxygenase system protein B (TmoB) Fmp27_WPPW PF10359.4 CDI76097.1 - 0.58 8.5 40.4 1.1 7.6 5.5 3.2 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain MKT1_C PF12246.3 CDI76098.1 - 0.048 12.6 0.7 0.098 11.6 0.5 1.4 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication Ycf1 PF05758.7 CDI76098.1 - 0.44 8.1 6.3 2.1 5.9 1.9 2.1 2 0 0 2 2 2 0 Ycf1 DUF4414 PF14377.1 CDI76098.1 - 0.69 9.8 30.9 0.23 11.3 2.5 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4414) Ribosomal_L36e PF01158.13 CDI76099.1 - 4.1e-37 126.1 7.2 4.6e-37 125.9 5.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e LemA PF04011.7 CDI76099.1 - 0.091 11.8 0.1 0.096 11.7 0.1 1.1 1 0 0 1 1 1 0 LemA family Bystin PF05291.6 CDI76100.1 - 1.2e-108 362.5 0.6 1.7e-108 362.1 0.4 1.1 1 0 0 1 1 1 1 Bystin Folate_rec PF03024.9 CDI76101.1 - 0.004 16.7 0.1 0.0047 16.5 0.1 1.2 1 0 0 1 1 1 1 Folate receptor family Peptidase_C1 PF00112.18 CDI76103.1 - 1.2e-49 169.2 0.5 1.7e-49 168.6 0.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease SSFA2_C PF14723.1 CDI76103.1 - 0.001 18.8 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Sperm-specific antigen 2 C-terminus Propeptide_C1 PF08127.8 CDI76103.1 - 0.0092 15.5 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.10 CDI76103.1 - 0.62 8.5 1.7 6.5 5.1 0.0 2.1 2 0 0 2 2 2 0 Peptidase C1-like family DEAD PF00270.24 CDI76104.1 - 2.1e-13 50.0 0.0 3.9e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI76104.1 - 1.9e-07 30.8 0.0 6.3e-07 29.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain T2SE PF00437.15 CDI76104.1 - 0.2 10.4 0.0 0.34 9.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein TTL PF03133.10 CDI76105.1 - 3e-18 65.7 0.0 7.7e-18 64.4 0.0 1.7 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 CDI76105.1 - 0.0041 15.9 0.0 0.0088 14.8 0.0 1.5 1 0 0 1 1 1 1 YheC/D like ATP-grasp Phostensin_N PF13916.1 CDI76105.1 - 0.76 9.8 5.9 0.35 10.8 0.9 2.5 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal MIP-T3 PF10243.4 CDI76106.1 - 0.081 11.3 65.0 0.1 11.0 45.0 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 EmrE PF13536.1 CDI76107.1 - 0.017 15.3 0.2 0.017 15.3 0.1 2.3 3 0 0 3 3 3 0 Multidrug resistance efflux transporter CRT-like PF08627.5 CDI76107.1 - 0.096 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 CRT-like Sugar_tr PF00083.19 CDI76108.1 - 5e-13 48.4 39.2 1.7e-09 36.8 8.9 2.7 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 CDI76108.1 - 7.5e-10 38.0 44.0 7.5e-10 38.0 30.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MutS_V PF00488.16 CDI76109.1 - 1.5e-09 37.5 6.0 0.0019 17.6 0.0 3.9 4 0 0 4 4 4 3 MutS domain V AAA_23 PF13476.1 CDI76109.1 - 0.031 14.6 0.0 0.031 14.6 0.0 4.3 5 1 0 5 5 5 0 AAA domain Proteasome PF00227.21 CDI76113.1 - 2.8e-34 118.0 0.0 4.5e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDI76113.1 - 1.6e-13 49.6 0.4 2.9e-13 48.8 0.1 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Med6 PF04934.9 CDI76117.1 - 7e-08 32.1 4.3 4.2e-05 23.1 0.0 3.2 3 0 0 3 3 3 2 MED6 mediator sub complex component DUF2201_N PF13203.1 CDI76117.1 - 0.0095 15.1 17.4 0.0099 15.0 8.0 2.3 2 0 0 2 2 2 1 Putative metallopeptidase domain FAM60A PF15396.1 CDI76117.1 - 0.019 14.7 8.4 0.017 14.8 4.2 1.9 2 0 0 2 2 2 0 Protein Family FAM60A PilP PF04351.8 CDI76117.1 - 0.028 14.3 0.1 0.028 14.3 0.1 2.3 2 0 0 2 2 2 0 Pilus assembly protein, PilP AAA_24 PF13479.1 CDI76117.1 - 0.22 11.0 0.0 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF3770 PF12603.3 CDI76117.1 - 0.42 9.6 6.5 0.6 9.1 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3770) Cwf_Cwc_15 PF04889.7 CDI76117.1 - 0.9 9.1 17.9 0.28 10.8 9.3 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RAP1 PF07218.6 CDI76117.1 - 0.96 7.4 4.6 1.3 7.0 3.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Mem_trans PF03547.13 CDI76117.1 - 1.2 7.3 4.1 1.7 6.8 2.9 1.2 1 0 0 1 1 1 0 Membrane transport protein Plasmodium_Vir PF05795.6 CDI76117.1 - 1.5 7.9 8.5 0.13 11.3 2.5 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein AUX_IAA PF02309.11 CDI76117.1 - 1.8 8.2 9.8 1.7 8.3 4.8 2.1 2 0 0 2 2 2 0 AUX/IAA family DUF572 PF04502.8 CDI76117.1 - 2.3 7.3 21.1 2 7.5 11.4 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF2217 PF10265.4 CDI76117.1 - 2.7 6.6 12.0 4.2 6.0 8.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Dicty_REP PF05086.7 CDI76117.1 - 3 5.4 6.6 4.2 4.9 4.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF755 PF05501.6 CDI76117.1 - 3 7.9 36.2 0.12 12.4 19.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Vfa1 PF08432.5 CDI76117.1 - 7 6.6 18.8 11 5.9 9.5 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2146 PF10220.4 CDI76117.1 - 7.1 4.4 14.4 0.11 10.4 5.1 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2146) DUF2052 PF09747.4 CDI76117.1 - 8.5 6.2 19.7 13 5.6 11.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) FimP PF09766.4 CDI76117.1 - 9 5.2 22.2 3.2 6.7 0.3 2.2 2 0 0 2 2 2 0 Fms-interacting protein Utp14 PF04615.8 CDI76118.1 - 3.6 5.6 13.6 4.4 5.3 9.4 1.2 1 0 0 1 1 1 0 Utp14 protein Serinc PF03348.10 CDI76118.1 - 5.3 5.6 5.6 10 4.6 3.9 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ribosomal_60s PF00428.14 CDI76120.1 - 0.01 16.2 25.1 0.036 14.4 4.0 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Shadoo PF14999.1 CDI76120.1 - 0.024 14.4 1.7 0.024 14.4 1.2 2.1 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Glt_symporter PF03616.9 CDI76120.1 - 0.044 12.2 0.7 0.06 11.8 0.5 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Med15 PF09606.5 CDI76120.1 - 0.061 11.5 39.3 0.072 11.2 27.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4647 PF15504.1 CDI76120.1 - 0.089 11.6 11.0 0.099 11.4 7.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF4179 PF13786.1 CDI76120.1 - 0.27 11.4 1.3 1.8 8.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) RskA PF10099.4 CDI76120.1 - 0.33 10.6 33.5 1.5 8.5 12.4 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA LCD1 PF09798.4 CDI76120.1 - 0.54 8.1 5.0 0.77 7.6 3.4 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein Inositol_P PF00459.20 CDI76120.1 - 1.1 8.4 8.1 0.14 11.4 1.4 1.8 1 1 0 2 2 2 0 Inositol monophosphatase family PLRV_ORF5 PF01690.12 CDI76120.1 - 4.1 6.4 10.9 4.6 6.2 7.6 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Med13_C PF06333.7 CDI76120.1 - 4.7 5.6 10.3 5.2 5.4 7.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal Parvo_coat PF00740.13 CDI76120.1 - 9.1 5.0 13.3 9.9 4.9 9.2 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 AAA_23 PF13476.1 CDI76120.1 - 9.2 6.5 9.3 12 6.1 6.4 1.1 1 0 0 1 1 1 0 AAA domain SOBP PF15279.1 CDI76120.1 - 9.6 6.4 15.9 11 6.2 11.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF382 PF04037.8 CDI76121.1 - 7.8e-52 174.4 0.3 7.8e-52 174.4 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.11 CDI76121.1 - 0.0036 16.6 1.0 0.0085 15.4 0.7 1.6 1 0 0 1 1 1 1 PSP Stimulus_sens_1 PF13756.1 CDI76121.1 - 0.24 11.8 9.6 0.26 11.7 0.1 3.7 3 0 0 3 3 3 0 Stimulus-sensing domain Hom_end_hint PF05203.11 CDI76121.1 - 0.42 10.3 6.6 0.86 9.2 4.6 1.5 1 0 0 1 1 1 0 Hom_end-associated Hint TFIIA PF03153.8 CDI76122.1 - 0.0017 18.3 20.1 0.0017 18.3 13.9 15.9 9 5 3 13 13 13 1 Transcription factor IIA, alpha/beta subunit APG9 PF04109.11 CDI76122.1 - 0.39 9.5 0.0 0.93 8.3 0.0 1.6 1 0 0 1 1 1 0 Autophagy protein Apg9 TPR_1 PF00515.23 CDI76123.1 - 1.9e-09 36.6 0.9 0.0064 16.0 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat Hydrolase_6 PF13344.1 CDI76124.1 - 6.4e-30 103.0 1.7 7.1e-29 99.6 0.3 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CDI76124.1 - 1.6e-08 34.1 0.1 1.6e-08 34.1 0.0 3.3 3 2 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.21 CDI76124.1 - 4.8e-06 27.1 1.0 4.8e-06 27.1 0.7 3.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Med15 PF09606.5 CDI76124.1 - 0.0021 16.3 15.2 0.0021 16.3 10.5 2.1 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Isy1 PF06246.7 CDI76124.1 - 0.013 14.9 4.2 0.02 14.2 2.9 1.2 1 0 0 1 1 1 0 Isy1-like splicing family Peptidase_S49_N PF08496.5 CDI76124.1 - 0.098 12.4 3.6 0.18 11.5 2.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Activator_LAG-3 PF11498.3 CDI76124.1 - 1.5 7.4 24.1 2.4 6.8 16.7 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4175 PF13779.1 CDI76124.1 - 2.1 5.9 19.9 3.7 5.1 13.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DivIC PF04977.10 CDI76124.1 - 5.1 6.6 11.8 9.5 5.7 8.2 1.4 1 0 0 1 1 1 0 Septum formation initiator Antimicrobial11 PF08106.6 CDI76125.1 - 0.061 13.1 2.0 0.13 12.1 1.4 1.6 1 0 0 1 1 1 0 Formaecin family CTP_transf_1 PF01148.15 CDI76127.1 - 1.1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Myc_N PF01056.13 CDI76128.1 - 0.052 12.7 6.9 0.072 12.2 4.8 1.2 1 0 0 1 1 1 0 Myc amino-terminal region B9-C2 PF07162.6 CDI76128.1 - 0.11 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein COPR5 PF15340.1 CDI76128.1 - 0.46 10.8 2.9 0.3 11.4 0.9 1.5 1 1 1 2 2 2 0 Cooperator of PRMT5 family DUF566 PF04484.7 CDI76128.1 - 0.77 9.2 15.3 0.94 8.9 10.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) PAP1 PF08601.5 CDI76128.1 - 0.89 9.1 13.9 0.91 9.1 9.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Presenilin PF01080.12 CDI76128.1 - 3 6.5 5.9 3.2 6.4 4.1 1.0 1 0 0 1 1 1 0 Presenilin Med15 PF09606.5 CDI76130.1 - 1.9 6.5 16.7 2.3 6.3 11.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 CDI76130.1 - 9.3 6.0 15.6 11 5.8 10.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.4 CDI76131.1 - 1.3 8.4 5.0 2.1 7.7 3.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ATP_bind_1 PF03029.12 CDI76133.1 - 4.2e-49 167.2 0.0 5.2e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.1 CDI76133.1 - 0.00025 20.9 0.0 0.0013 18.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDI76133.1 - 0.0025 18.5 0.2 0.0056 17.4 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI76133.1 - 0.003 17.5 0.0 0.13 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 CDI76133.1 - 0.0075 16.2 0.2 0.041 13.8 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.1 CDI76133.1 - 0.016 15.0 0.0 0.021 14.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 CDI76133.1 - 0.017 14.5 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.5 CDI76133.1 - 0.031 13.5 0.0 0.065 12.4 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_10 PF12846.2 CDI76133.1 - 0.031 13.7 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 CDI76133.1 - 0.06 12.8 0.0 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain SSP160 PF06933.6 CDI76133.1 - 8 4.3 11.0 9.7 4.0 7.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ATP_bind_1 PF03029.12 CDI76134.1 - 1.7e-12 47.4 0.0 2.4e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein WD40 PF00400.27 CDI76138.1 - 3.3e-08 33.1 0.1 7.4e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat TIMELESS_C PF05029.8 CDI76139.1 - 0.13 11.1 5.0 0.14 11.0 3.4 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region PepSY_2 PF13670.1 CDI76139.1 - 0.14 12.1 1.6 0.18 11.7 1.1 1.2 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain CCDC142 PF14923.1 CDI76139.1 - 1.1 7.5 10.4 1.3 7.2 7.2 1.0 1 0 0 1 1 1 0 Coiled-coil protein 142 Cwf_Cwc_15 PF04889.7 CDI76139.1 - 1.7 8.3 8.0 2 8.0 5.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SpoIIIAH PF12685.2 CDI76139.1 - 2 7.8 9.9 2.1 7.7 6.9 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF1675 PF07897.6 CDI76139.1 - 4.2 7.1 14.5 5.2 6.8 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) FAM60A PF15396.1 CDI76139.1 - 4.4 6.9 9.4 5.4 6.7 6.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF1980 PF09323.5 CDI76139.1 - 5.2 6.7 10.7 45 3.7 7.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2217 PF10265.4 CDI76139.1 - 5.8 5.5 15.4 6.1 5.4 10.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) SLD3 PF08639.5 CDI76139.1 - 7.5 5.0 14.7 8 4.9 10.2 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 VirE2 PF07229.7 CDI76139.1 - 7.9 4.7 9.7 8.7 4.6 6.7 1.0 1 0 0 1 1 1 0 VirE2 Presenilin PF01080.12 CDI76139.1 - 8.3 5.1 12.6 8.8 5.0 8.7 1.0 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.4 CDI76140.1 - 0.00033 19.0 65.7 0.00033 19.0 45.6 3.2 2 1 1 3 3 3 1 Topoisomerase II-associated protein PAT1 FHIPEP PF00771.15 CDI76142.1 - 0.16 10.2 1.2 0.26 9.5 0.9 1.3 1 0 0 1 1 1 0 FHIPEP family DUF4647 PF15504.1 CDI76142.1 - 0.58 8.9 29.2 0.74 8.6 20.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Ribosomal_60s PF00428.14 CDI76142.1 - 1.2 9.6 7.4 2.5 8.5 5.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein 14-3-3 PF00244.15 CDI76144.1 - 4.6e-13 48.8 4.1 1.4e-06 27.5 0.0 2.9 3 0 0 3 3 3 2 14-3-3 protein ArgK PF03308.11 CDI76144.1 - 0.066 11.9 0.2 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 ArgK protein RAP1 PF07218.6 CDI76144.1 - 0.72 7.8 7.3 0.97 7.4 5.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Lin-8 PF03353.10 CDI76144.1 - 1.7 7.8 11.2 0.42 9.8 0.4 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF4569 PF15133.1 CDI76144.1 - 1.8 7.9 13.7 0.5 9.7 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) FAM150 PF15129.1 CDI76144.1 - 2.1 8.2 4.8 0.41 10.5 0.7 1.8 2 0 0 2 2 2 0 FAM150 family DUF908 PF06012.7 CDI76144.1 - 5.1 6.2 8.1 12 5.1 5.5 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) SecY PF00344.15 CDI76145.1 - 5.2e-96 321.5 18.9 6.3e-96 321.3 13.1 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 CDI76145.1 - 1.4e-18 66.1 0.1 5.2e-18 64.2 0.0 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p Ribosomal_60s PF00428.14 CDI76146.1 - 1.3 9.4 5.8 1.8 9.0 4.0 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein RRM_1 PF00076.17 CDI76147.1 - 8.1e-38 127.8 0.0 4.1e-19 67.9 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76147.1 - 9.1e-28 96.0 0.0 1.1e-14 54.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76147.1 - 1.5e-13 50.3 0.0 6.3e-06 25.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CDI76147.1 - 2.6e-05 23.8 0.0 0.18 11.5 0.0 2.3 2 0 0 2 2 2 2 Limkain b1 RRM_3 PF08777.6 CDI76147.1 - 0.00024 20.9 0.0 0.77 9.6 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.1 CDI76147.1 - 0.026 14.2 0.0 1.6 8.5 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif ATP-grasp_2 PF08442.5 CDI76147.1 - 0.38 10.1 0.0 0.38 10.1 0.0 2.3 3 0 0 3 3 3 0 ATP-grasp domain WD40 PF00400.27 CDI76148.1 - 5.5e-12 45.0 0.0 3.8e-06 26.5 0.0 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat TFIIA PF03153.8 CDI76148.1 - 0.14 11.9 19.3 0.22 11.4 13.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI76148.1 - 1.8 6.6 32.8 2.8 6.0 22.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.9 CDI76148.1 - 2.3 7.8 20.2 3.9 7.1 14.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spore_coat_CotO PF14153.1 CDI76148.1 - 9.3 5.6 17.9 16 4.8 12.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Guanylate_cyc PF00211.15 CDI76150.1 - 4.6e-20 71.7 0.0 3.7e-11 42.7 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF572 PF04502.8 CDI76152.1 - 9.7e-71 238.6 15.3 9.7e-71 238.6 10.6 4.6 3 2 0 3 3 3 1 Family of unknown function (DUF572) PAPS_reduct PF01507.14 CDI76152.1 - 0.6 9.9 4.9 10 5.8 0.8 3.5 2 1 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Ribosomal_L11_N PF03946.9 CDI76153.1 - 1e-22 79.3 0.2 2.1e-22 78.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 CDI76153.1 - 6.9e-21 74.1 0.0 9.9e-21 73.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain NifU_N PF01592.11 CDI76157.1 - 1.8e-47 160.4 0.2 2.1e-47 160.1 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain BT1 PF03092.11 CDI76158.1 - 2.7e-77 260.3 13.7 3.7e-77 259.8 9.5 1.1 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 CDI76158.1 - 5.6e-13 48.3 30.2 5.7e-08 31.8 6.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDI76158.1 - 2.1e-05 23.1 5.8 2.1e-05 23.1 4.0 2.7 2 2 1 3 3 3 1 MFS/sugar transport protein Evr1_Alr PF04777.8 CDI76159.1 - 0.00023 20.9 0.0 0.00047 20.0 0.0 1.5 1 0 0 1 1 1 1 Erv1 / Alr family Totivirus_coat PF05518.6 CDI76159.1 - 0.034 11.9 5.2 0.042 11.6 3.6 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ribosomal_60s PF00428.14 CDI76161.1 - 0.0044 17.3 0.4 0.0044 17.3 0.2 5.9 3 2 1 4 4 4 1 60s Acidic ribosomal protein SMC_N PF02463.14 CDI76162.1 - 2.1e-09 36.9 0.0 3.8e-08 32.8 0.0 2.5 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SR-25 PF10500.4 CDI76162.1 - 4.2e-05 23.1 30.8 4.2e-05 23.1 21.3 8.6 7 1 1 8 8 8 1 Nuclear RNA-splicing-associated protein SprA-related PF12118.3 CDI76162.1 - 6.5e-05 22.4 30.9 6.5e-05 22.4 21.4 7.7 5 2 0 5 5 5 2 SprA-related family RNA_pol_Rpb5_C PF01191.14 CDI76163.1 - 5.2e-34 115.6 0.5 5.2e-34 115.6 0.3 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 CDI76163.1 - 5e-13 49.2 0.0 5e-13 49.2 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.7 CDI76163.1 - 0.014 15.1 0.0 0.014 15.1 0.0 2.0 2 0 0 2 2 2 0 Restriction endonuclease GET2 PF08690.5 CDI76163.1 - 0.54 9.4 10.8 1.5 8.0 7.5 1.8 1 0 0 1 1 1 0 GET complex subunit GET2 RGS-like PF09128.6 CDI76163.1 - 1.3 8.4 12.3 5.2 6.5 6.2 2.5 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain Hid1 PF12722.2 CDI76163.1 - 4.4 4.8 11.1 6.6 4.2 7.7 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hydrolase_6 PF13344.1 CDI76166.1 - 0.13 12.1 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DnaJ PF00226.26 CDI76172.1 - 1.1e-16 60.3 0.2 1.3e-13 50.5 0.0 2.4 2 0 0 2 2 2 2 DnaJ domain CTDII PF01556.13 CDI76172.1 - 4.7e-08 32.8 0.5 1e-07 31.7 0.0 1.8 2 0 0 2 2 2 1 DnaJ C terminal domain DUF572 PF04502.8 CDI76172.1 - 0.061 12.5 5.0 0.19 10.9 3.5 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF572) Mito_fiss_reg PF05308.6 CDI76172.1 - 5.2 6.3 24.4 0.11 11.8 9.5 2.7 2 0 0 2 2 2 0 Mitochondrial fission regulator KR PF08659.5 CDI76173.1 - 1.5 8.4 0.0 1.5 8.4 0.0 2.9 1 1 2 3 3 3 0 KR domain Glyco_hydro_63 PF03200.11 CDI76173.1 - 5.7 4.6 16.8 7.5 4.2 11.6 1.1 1 0 0 1 1 1 0 Mannosyl oligosaccharide glucosidase TFIIA PF03153.8 CDI76173.1 - 8.5 6.1 45.9 11 5.7 31.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_Rpb1_5 PF04998.12 CDI76181.1 - 6e-18 65.0 0.1 7.5e-18 64.7 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Uteroglobin PF01099.12 CDI76181.1 - 0.035 13.8 0.2 0.15 11.9 0.1 2.0 2 0 0 2 2 2 0 Uteroglobin family DUF2057 PF09829.4 CDI76181.1 - 0.19 11.4 4.1 0.27 10.8 2.8 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Ribosomal_60s PF00428.14 CDI76181.1 - 1.1 9.6 9.6 2.5 8.5 6.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein SAP PF02037.22 CDI76182.1 - 8.3e-14 50.6 2.0 3e-13 48.9 0.1 2.2 2 0 0 2 2 2 1 SAP domain HeH PF12949.2 CDI76182.1 - 0.013 15.0 0.0 0.03 13.8 0.0 1.6 1 1 0 1 1 1 0 HeH/LEM domain UPF0175 PF03683.8 CDI76182.1 - 0.085 12.3 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) Med3 PF11593.3 CDI76182.1 - 0.24 10.5 14.5 0.34 10.1 10.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Tom22 PF04281.8 CDI76185.1 - 0.001 18.6 11.0 0.001 18.6 7.6 1.8 2 0 0 2 2 1 1 Mitochondrial import receptor subunit Tom22 Peptidase_C37 PF05416.7 CDI76185.1 - 0.0055 15.0 2.2 0.011 14.1 1.5 1.4 1 0 0 1 1 1 1 Southampton virus-type processing peptidase CD20 PF04103.10 CDI76185.1 - 0.0056 16.6 0.5 0.043 13.7 0.0 2.3 2 0 0 2 2 2 1 CD20-like family DUF3682 PF12446.3 CDI76185.1 - 0.0066 16.7 20.8 0.0066 16.7 14.4 3.1 3 0 0 3 3 1 1 Protein of unknown function (DUF3682) Zip PF02535.17 CDI76185.1 - 0.13 11.2 4.1 0.064 12.2 0.6 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF912 PF06024.7 CDI76185.1 - 0.19 11.8 7.3 0.57 10.2 1.2 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PBP1_TM PF14812.1 CDI76185.1 - 0.46 10.8 7.3 0.25 11.6 0.7 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-DHHC PF01529.15 CDI76185.1 - 0.61 9.4 4.5 1.9 7.8 0.3 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase Peroxin-13_N PF04088.8 CDI76185.1 - 0.89 9.4 6.3 8.7 6.2 1.6 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region DUF1510 PF07423.6 CDI76185.1 - 1.1 8.6 18.2 3.9 6.7 7.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) FAM176 PF14851.1 CDI76185.1 - 1.2 8.7 8.1 3.4 7.3 1.9 2.5 2 0 0 2 2 2 0 FAM176 family FPN1 PF06963.7 CDI76185.1 - 1.9 6.7 9.0 4.4 5.5 2.2 2.3 2 0 0 2 2 2 0 Ferroportin1 (FPN1) Glyco_transf_15 PF01793.11 CDI76185.1 - 2.6 6.8 11.0 8.8 5.1 5.0 2.2 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase EIIBC-GUT_N PF03612.9 CDI76185.1 - 2.8 7.5 13.5 2.8 7.4 0.2 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Suf PF05843.9 CDI76185.1 - 3.3 7.3 28.8 2.7 7.6 1.5 2.3 2 1 0 2 2 2 0 Suppressor of forked protein (Suf) AUX_IAA PF02309.11 CDI76185.1 - 3.6 7.2 10.6 4.9 6.8 3.7 2.2 2 0 0 2 2 2 0 AUX/IAA family DUF913 PF06025.7 CDI76185.1 - 3.6 6.2 9.0 0.69 8.5 2.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Spore_YhcN_YlaJ PF09580.5 CDI76185.1 - 4 7.5 13.7 0.44 10.6 2.4 2.3 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Nse4_C PF08743.5 CDI76185.1 - 5.5 7.0 9.6 0.41 10.6 1.3 2.4 2 0 0 2 2 2 0 Nse4 C-terminal Tim54 PF11711.3 CDI76185.1 - 5.7 5.4 13.5 3.5 6.1 5.1 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 FAM60A PF15396.1 CDI76185.1 - 5.9 6.5 9.0 5.5 6.6 2.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Cwf_Cwc_15 PF04889.7 CDI76185.1 - 6 6.5 26.6 0.8 9.3 4.0 2.4 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein DUF3675 PF12428.3 CDI76185.1 - 7.8 6.7 6.8 3.7 7.8 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) AMP-binding PF00501.23 CDI76186.1 - 8.4e-33 113.3 0.0 1e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme BAF1_ABF1 PF04684.8 CDI76187.1 - 0.63 8.8 38.5 0.51 9.1 8.4 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Spt20 PF12090.3 CDI76187.1 - 0.75 9.1 15.2 0.037 13.3 2.3 2.2 2 0 0 2 2 2 0 Spt20 family Elongin_A PF06881.6 CDI76187.1 - 1 9.7 15.1 0.11 12.8 4.5 2.7 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Hist_deacetyl PF00850.14 CDI76187.1 - 2.4 7.3 8.9 1.6 7.9 0.3 2.2 2 0 0 2 2 2 0 Histone deacetylase domain BRF1 PF07741.8 CDI76187.1 - 5.9 7.1 20.9 1.7 8.9 5.6 2.7 2 0 0 2 2 2 0 Brf1-like TBP-binding domain RAB3GAP2_N PF14655.1 CDI76187.1 - 7.3 5.4 17.6 0.53 9.2 3.6 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus GCFC PF07842.7 CDI76188.1 - 4.4e-31 108.2 17.8 4.4e-31 108.2 12.3 3.1 3 1 0 3 3 3 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.18 CDI76188.1 - 4.5e-08 32.7 2.6 1.3e-07 31.2 1.8 1.8 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.3 CDI76188.1 - 0.0016 18.4 9.2 0.0016 18.4 6.4 6.8 4 1 2 6 6 6 1 Tuftelin interacting protein N terminal ERCC4 PF02732.10 CDI76189.1 - 1.6e-14 53.9 0.0 9.2e-14 51.4 0.0 2.4 2 0 0 2 2 2 1 ERCC4 domain SR-25 PF10500.4 CDI76189.1 - 0.00098 18.6 5.0 0.00098 18.6 3.4 7.1 4 2 0 5 5 5 1 Nuclear RNA-splicing-associated protein DUF3273 PF11677.3 CDI76195.1 - 1.5e-20 73.5 0.0 1.7e-20 73.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Dynein_light PF01221.13 CDI76196.1 - 2.7e-25 88.1 0.1 3.3e-25 87.8 0.1 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF1635 PF07795.6 CDI76197.1 - 0.039 13.3 1.6 0.054 12.8 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Gluconate_2-dh3 PF13618.1 CDI76197.1 - 3.5 7.7 5.9 8.1 6.6 4.1 1.7 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 Wbp11 PF09429.5 CDI76198.1 - 9.4e-12 44.7 12.9 9.4e-12 44.7 8.9 2.8 2 1 0 2 2 2 1 WW domain binding protein 11 MSC PF09402.5 CDI76198.1 - 0.15 10.7 0.6 0.32 9.6 0.4 1.4 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain DNase_NucA_NucB PF14040.1 CDI76198.1 - 0.49 10.5 6.4 0.048 13.7 0.6 2.2 2 0 0 2 2 2 0 Deoxyribonuclease NucA/NucB FoP_duplication PF13865.1 CDI76198.1 - 1.7 9.1 12.0 1.6 9.2 0.1 3.6 3 0 0 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 Barttin PF15462.1 CDI76200.1 - 0.21 11.2 4.4 0.36 10.4 3.0 1.4 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) RabGAP-TBC PF00566.13 CDI76201.1 - 5.5e-46 156.7 0.0 5.5e-46 156.7 0.0 2.4 3 0 0 3 3 3 1 Rab-GTPase-TBC domain zinc_ribbon_6 PF14599.1 CDI76202.1 - 1e-20 73.2 0.4 1e-20 73.2 0.3 3.5 5 0 0 5 5 5 1 Zinc-ribbon zf-CHY PF05495.7 CDI76202.1 - 3.1e-13 49.6 21.1 3.1e-13 49.6 14.6 3.6 1 1 2 3 3 3 1 CHY zinc finger zf-RING_UBOX PF13445.1 CDI76202.1 - 5.9e-06 25.9 2.9 5.9e-06 25.9 2.0 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 CDI76202.1 - 0.00021 20.9 8.7 0.00021 20.9 6.0 5.4 4 2 1 5 5 5 3 zinc-RING finger domain zf-C3HC4_4 PF15227.1 CDI76202.1 - 0.0058 16.4 4.2 0.0058 16.4 2.9 4.6 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING DUF2058 PF09831.4 CDI76203.1 - 2.5 7.9 9.8 4.3 7.2 6.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) DnaJ PF00226.26 CDI76204.1 - 1.2e-17 63.3 5.4 1.2e-17 63.3 3.7 3.1 2 1 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.26 CDI76204.1 - 2.5e-06 27.4 1.0 7.5e-06 25.8 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDI76204.1 - 0.00056 19.9 0.0 0.00056 19.9 0.0 2.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain DDRGK PF09756.4 CDI76204.1 - 0.18 11.1 34.5 0.1 11.9 13.1 2.5 2 0 0 2 2 2 0 DDRGK domain PocR PF10114.4 CDI76204.1 - 1.8 7.6 4.5 4.5 6.3 0.0 2.8 3 0 0 3 3 3 0 Sensory domain found in PocR CRAL_TRIO PF00650.15 CDI76205.1 - 1.3e-20 73.4 0.0 1.9e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 CDI76205.1 - 0.094 12.6 0.1 0.2 11.5 0.0 1.6 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain Ycf1 PF05758.7 CDI76208.1 - 0.42 8.2 4.2 0.58 7.7 2.9 1.1 1 0 0 1 1 1 0 Ycf1 CENP-T PF15511.1 CDI76208.1 - 1.1 8.4 33.2 0.079 12.1 7.2 3.0 3 0 0 3 3 3 0 Centromere kinetochore component CENP-T CDC45 PF02724.9 CDI76208.1 - 1.2 7.1 14.0 0.5 8.3 4.2 2.1 2 0 0 2 2 2 0 CDC45-like protein BORG_CEP PF14957.1 CDI76208.1 - 1.3 9.9 9.3 0.26 12.2 1.3 3.2 4 0 0 4 4 4 0 Cdc42 effector BUD22 PF09073.5 CDI76208.1 - 1.8 7.5 21.3 0.55 9.2 8.4 2.2 2 0 0 2 2 2 0 BUD22 Vfa1 PF08432.5 CDI76208.1 - 3.4 7.6 20.8 3.2 7.7 10.0 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Afi1 PF07792.7 CDI76208.1 - 3.7 7.5 16.0 4.1 7.4 0.0 3.1 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Utp14 PF04615.8 CDI76208.1 - 6.9 4.7 23.6 10 4.1 16.4 1.1 1 0 0 1 1 1 0 Utp14 protein Cpn60_TCP1 PF00118.19 CDI76209.1 - 6.8e-160 532.8 3.9 7.7e-160 532.6 2.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Longin PF13774.1 CDI76212.1 - 5.1e-15 54.7 0.0 8.2e-15 54.1 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 CDI76212.1 - 3.3e-09 36.2 0.5 3.3e-09 36.2 0.3 2.0 2 0 0 2 2 2 1 Synaptobrevin PRTP PF01366.13 CDI76212.1 - 0.019 12.9 0.0 0.025 12.6 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein HMG_box PF00505.14 CDI76213.1 - 1.5e-19 69.9 2.2 2.2e-19 69.5 1.5 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDI76213.1 - 2.1e-10 40.8 3.2 3.1e-10 40.2 2.2 1.3 1 0 0 1 1 1 1 HMG-box domain Tol_Tol_Ttg2 PF05494.7 CDI76213.1 - 0.0032 17.0 0.7 0.0043 16.6 0.5 1.3 1 0 0 1 1 1 1 Toluene tolerance, Ttg2 CAF-1_p150 PF11600.3 CDI76213.1 - 0.05 12.9 8.1 0.063 12.6 5.6 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal FancD2 PF14631.1 CDI76213.1 - 0.3 8.1 1.7 0.36 7.8 1.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RAP1 PF07218.6 CDI76213.1 - 0.31 9.0 9.3 0.31 9.0 6.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SAGA-Tad1 PF12767.2 CDI76213.1 - 0.42 10.2 4.4 0.56 9.8 3.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF605 PF04652.11 CDI76215.1 - 0.0028 17.1 18.9 0.0028 17.1 13.1 8.1 3 1 4 7 7 7 1 Vta1 like Hexokinase_2 PF03727.11 CDI76215.1 - 0.059 12.5 7.5 0.22 10.7 5.2 2.0 1 0 0 1 1 1 0 Hexokinase Ras PF00071.17 CDI76217.1 - 2e-19 69.5 0.4 2.3e-19 69.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI76217.1 - 1.9e-06 28.3 0.3 2.8e-06 27.7 0.2 1.4 1 1 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 CDI76217.1 - 0.0036 17.6 1.5 0.0054 17.0 1.1 1.3 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 CDI76217.1 - 0.0036 17.3 0.3 0.0046 16.9 0.2 1.2 1 0 0 1 1 1 1 AAA ATPase domain ResIII PF04851.10 CDI76217.1 - 0.0049 16.7 0.1 0.0063 16.3 0.1 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Spt20 PF12090.3 CDI76217.1 - 0.0058 16.0 1.8 0.0073 15.6 1.2 1.1 1 0 0 1 1 1 1 Spt20 family AAA_28 PF13521.1 CDI76217.1 - 0.018 15.0 0.1 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CDI76217.1 - 0.019 15.1 0.3 0.032 14.3 0.2 1.5 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CDI76217.1 - 0.024 14.5 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase DAP3 PF10236.4 CDI76217.1 - 0.033 13.1 1.7 0.13 11.1 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.1 CDI76217.1 - 0.034 13.7 3.9 0.033 13.7 1.2 1.7 1 1 1 2 2 2 0 AAA domain Arf PF00025.16 CDI76217.1 - 0.04 13.1 1.3 0.084 12.1 0.1 1.7 1 1 1 2 2 2 0 ADP-ribosylation factor family DUF258 PF03193.11 CDI76217.1 - 0.045 12.9 0.8 0.067 12.3 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 CDI76217.1 - 0.14 11.7 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Suf PF05843.9 CDI76217.1 - 0.6 9.7 5.2 0.63 9.7 3.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CcmD PF04995.9 CDI76217.1 - 1.5 8.6 6.3 3.2 7.5 4.3 1.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) TSA PF03249.8 CDI76217.1 - 7.6 4.9 8.9 7.2 5.0 6.2 1.2 1 0 0 1 1 1 0 Type specific antigen Med3 PF11593.3 CDI76217.1 - 9.9 5.2 13.3 12 4.9 9.2 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal THRAP3_BCLAF1 PF15440.1 CDI76218.1 - 0.21 10.1 31.9 0.27 9.8 22.1 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Bud13 PF09736.4 CDI76218.1 - 4.2 7.6 22.8 1.3 9.3 5.4 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex WD40 PF00400.27 CDI76219.1 - 5.2e-14 51.5 31.3 7.9e-05 22.3 0.0 9.3 12 0 0 12 12 12 6 WD domain, G-beta repeat zf-MYND PF01753.13 CDI76220.1 - 0.034 14.0 10.9 0.057 13.3 7.5 1.4 1 0 0 1 1 1 0 MYND finger Pkinase PF00069.20 CDI76221.1 - 2.1e-42 145.0 0.4 7.2e-23 81.0 0.5 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76221.1 - 3e-20 72.3 0.4 3.7e-15 55.7 0.5 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase PH PF00169.24 CDI76221.1 - 1.8e-13 50.5 0.0 3.2e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.27 CDI76221.1 - 3e-10 38.6 0.4 0.00011 21.2 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 CDI76221.1 - 5.7e-09 34.9 0.5 0.00045 19.4 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CDI76221.1 - 8.7e-09 34.5 0.3 0.00056 19.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 CDI76221.1 - 5.7e-06 25.8 2.2 0.0002 20.9 0.2 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 CDI76221.1 - 1.1e-05 25.4 0.7 0.00057 19.9 0.2 3.3 2 1 2 4 4 4 3 EF-hand domain pair PH_8 PF15409.1 CDI76221.1 - 0.0041 17.1 0.1 0.014 15.4 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain eIF-1a PF01176.14 CDI76223.1 - 1.5e-08 33.9 0.0 1.7e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Translation initiation factor 1A / IF-1 SR-25 PF10500.4 CDI76223.1 - 4 6.8 15.9 5.9 6.3 11.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pap_E4 PF02711.9 CDI76223.1 - 8.2 7.3 8.7 3.7 8.4 0.7 2.2 2 0 0 2 2 2 0 E4 protein DivIC PF04977.10 CDI76224.1 - 0.014 14.8 2.9 0.014 14.8 2.0 4.3 4 1 1 5 5 5 0 Septum formation initiator AKAP7_NLS PF10469.4 CDI76224.1 - 0.34 10.5 4.3 0.59 9.8 2.3 1.8 1 1 1 2 2 2 0 AKAP7 2'5' RNA ligase-like domain GST_C PF00043.20 CDI76224.1 - 0.58 10.1 5.9 0.47 10.4 0.2 2.9 1 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain AATF-Che1 PF13339.1 CDI76224.1 - 0.63 10.2 24.7 0.12 12.4 4.4 2.8 1 1 2 3 3 3 0 Apoptosis antagonizing transcription factor GCC2_GCC3 PF07699.8 CDI76225.1 - 0.04 13.4 8.7 0.16 11.6 0.0 3.7 4 0 0 4 4 4 0 GCC2 and GCC3 FXa_inhibition PF14670.1 CDI76225.1 - 0.044 13.9 6.9 0.26 11.4 2.9 2.9 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Cytomega_UL20A PF05984.7 CDI76225.1 - 0.065 13.4 0.5 0.15 12.2 0.3 1.6 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein EGF_MSP1_1 PF12946.2 CDI76225.1 - 0.18 11.6 4.8 0.21 11.3 1.1 2.9 2 1 0 2 2 2 0 MSP1 EGF domain 1 PT PF04886.7 CDI76226.1 - 0.43 9.9 4.2 1.4 8.2 0.2 2.4 2 0 0 2 2 2 0 PT repeat DUF4614 PF15391.1 CDI76227.1 - 0.06 13.1 5.5 0.065 13.0 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CAF-1_p150 PF11600.3 CDI76227.1 - 6.1 6.1 10.9 6.7 6.0 7.6 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PAT1 PF09770.4 CDI76228.1 - 0.55 8.4 23.8 0.86 7.7 16.2 1.5 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF966 PF06136.8 CDI76228.1 - 2.2 7.5 13.0 3.4 6.9 6.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Glyco_transf_8 PF01501.15 CDI76229.1 - 1.3e-11 44.3 6.3 1.3e-11 44.3 4.4 4.1 5 1 0 5 5 5 1 Glycosyl transferase family 8 DUF605 PF04652.11 CDI76229.1 - 4.6e-05 22.9 21.3 4.6e-05 22.9 14.7 4.0 3 2 0 3 3 3 1 Vta1 like SART-1 PF03343.8 CDI76230.1 - 4.8e-55 187.0 65.9 3.2e-53 181.0 45.7 3.1 1 1 0 1 1 1 1 SART-1 family MPP6 PF10175.4 CDI76231.1 - 0.0038 17.5 1.3 0.37 11.1 0.0 2.8 2 1 1 3 3 3 1 M-phase phosphoprotein 6 DUF4357 PF14267.1 CDI76231.1 - 0.0067 16.0 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4357) RskA PF10099.4 CDI76231.1 - 0.059 13.1 4.7 0.026 14.2 1.6 1.6 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Shadoo PF14999.1 CDI76231.1 - 0.093 12.5 3.7 0.029 14.2 0.8 1.4 1 1 1 2 2 2 0 Shadow of prion protein, neuroprotective SBP_bac_5 PF00496.17 CDI76231.1 - 0.21 10.3 3.3 0.25 10.1 2.3 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle Chorion_2 PF03964.10 CDI76231.1 - 0.22 12.0 6.1 0.099 13.2 2.0 1.8 2 0 0 2 2 2 0 Chorion family 2 K_channel_TID PF07941.6 CDI76231.1 - 0.23 11.6 9.0 0.065 13.4 2.6 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s PF00428.14 CDI76231.1 - 0.44 10.9 9.4 0.35 11.2 2.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Sec16_C PF12931.2 CDI76234.1 - 3.1e-15 56.6 0.1 3.1e-15 56.6 0.0 4.2 3 1 0 3 3 3 1 Sec23-binding domain of Sec16 SIR2 PF02146.12 CDI76235.1 - 2.2e-14 53.5 0.2 8.3e-08 32.1 0.2 4.2 5 1 1 6 6 6 2 Sir2 family BAF1_ABF1 PF04684.8 CDI76237.1 - 2.2e-05 23.5 19.3 2.2e-05 23.5 13.4 10.9 10 2 2 12 12 12 2 BAF1 / ABF1 chromatin reorganising factor CagX PF03524.10 CDI76237.1 - 0.005 16.1 0.0 0.005 16.1 0.0 6.1 6 0 0 6 6 6 1 Conjugal transfer protein Zip PF02535.17 CDI76237.1 - 0.74 8.7 54.3 0.017 14.1 15.4 4.2 5 0 0 5 5 5 0 ZIP Zinc transporter Cnd2 PF05786.9 CDI76238.1 - 3.1e-28 98.7 24.8 9.1e-21 74.0 4.3 3.3 3 0 0 3 3 3 3 Condensin complex subunit 2 DUF755 PF05501.6 CDI76238.1 - 0.0012 18.8 26.4 0.0012 18.8 18.3 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF755) UPF0564 PF10595.4 CDI76238.1 - 0.64 8.8 34.3 0.021 13.7 8.4 3.3 4 0 0 4 4 4 0 Uncharacterised protein family UPF0564 Dehydrin PF00257.14 CDI76238.1 - 4.2 7.6 17.4 1.1 9.6 6.8 3.0 2 0 0 2 2 2 0 Dehydrin PAN_4 PF14295.1 CDI76239.1 - 1.3e-14 53.6 22.2 6.6e-06 25.7 0.3 5.1 4 1 0 4 4 4 4 PAN domain PAN_1 PF00024.21 CDI76239.1 - 6.1e-13 48.3 17.9 1.5e-06 27.8 0.9 4.3 3 1 1 4 4 4 4 PAN domain E1-E2_ATPase PF00122.15 CDI76239.1 - 0.005 15.9 0.0 0.0063 15.5 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase PAN_3 PF08277.7 CDI76239.1 - 0.034 13.7 12.0 0.13 11.9 0.4 3.3 2 1 1 3 3 3 0 PAN-like domain MANEC PF07502.9 CDI76239.1 - 6.7 6.7 20.6 1.2 9.1 0.7 4.0 2 2 1 4 4 4 0 MANEC domain RabGAP-TBC PF00566.13 CDI76244.1 - 3e-24 85.6 0.4 8e-24 84.3 0.3 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.20 CDI76244.1 - 3.5e-11 42.7 0.0 5.1e-06 25.8 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76244.1 - 1.3e-06 27.7 0.0 2e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI76244.1 - 0.0074 15.2 0.0 0.016 14.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Rhodanese PF00581.15 CDI76244.1 - 0.023 15.0 0.0 1.8 8.9 0.0 2.9 2 0 0 2 2 2 0 Rhodanese-like domain zf-CCCH PF00642.19 CDI76245.1 - 3.9e-10 39.1 13.2 2.2e-05 23.9 1.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 CDI76245.1 - 3.3e-09 36.4 0.0 5.9e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI76245.1 - 3e-05 23.5 0.0 6.6e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76245.1 - 0.023 14.6 0.0 0.051 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF2626 PF11117.3 CDI76246.1 - 0.4 11.1 3.1 2.6 8.5 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2626) JmjC PF02373.17 CDI76249.1 - 2.5e-20 72.8 0.1 2.5e-20 72.8 0.1 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 CDI76249.1 - 8.8e-19 67.9 0.1 2.7e-14 53.2 0.0 2.7 1 1 1 2 2 2 2 Cupin-like domain Cupin_4 PF08007.7 CDI76249.1 - 0.012 14.9 0.7 0.029 13.6 0.0 2.1 2 1 0 2 2 2 0 Cupin superfamily protein GPI PF06560.6 CDI76249.1 - 0.056 12.4 0.1 0.11 11.5 0.1 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Cupin_2 PF07883.6 CDI76249.1 - 0.068 12.6 0.0 0.19 11.2 0.0 1.7 1 0 0 1 1 1 0 Cupin domain L51_S25_CI-B8 PF05047.11 CDI76249.1 - 0.11 12.2 1.1 0.39 10.5 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Mlo PF03094.10 CDI76250.1 - 1.9e-08 32.9 7.7 6.5e-06 24.5 3.8 3.4 3 1 0 3 3 3 2 Mlo family LysE PF01810.13 CDI76250.1 - 0.0099 15.1 4.2 0.81 8.9 0.1 2.7 3 0 0 3 3 3 2 LysE type translocator COX2_TM PF02790.10 CDI76250.1 - 0.11 12.4 0.2 0.11 12.4 0.1 3.2 3 1 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain UCH PF00443.24 CDI76252.1 - 1.8e-64 217.4 0.0 1.3e-63 214.5 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDI76252.1 - 9e-19 68.0 1.7 4.1e-10 39.5 0.0 3.5 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Rsa3 PF14615.1 CDI76252.1 - 0.29 10.4 0.9 3.1 7.1 0.0 2.6 3 0 0 3 3 3 0 Ribosome-assembly protein 3 LCCL PF03815.14 CDI76253.1 - 2.2e-22 78.8 0.0 4.3e-19 68.2 0.0 2.4 2 0 0 2 2 2 2 LCCL domain Laminin_G_3 PF13385.1 CDI76253.1 - 3.8e-05 23.9 0.0 7.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Rxt3 PF08642.5 CDI76253.1 - 0.022 14.9 0.1 0.26 11.5 0.0 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Phostensin_N PF13916.1 CDI76253.1 - 0.11 12.5 3.9 0.18 11.7 2.7 1.3 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal TFIIF_alpha PF05793.7 CDI76256.1 - 6.7 4.9 28.2 10 4.3 19.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Utp14 PF04615.8 CDI76256.1 - 7.9 4.5 34.2 9.5 4.2 23.7 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4175 PF13779.1 CDI76256.1 - 8.7 3.9 42.1 9.5 3.7 29.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Bac_Ubq_Cox PF01654.12 CDI76257.1 - 2.5 6.4 11.1 0.092 11.1 2.9 2.1 2 0 0 2 2 2 0 Bacterial Cytochrome Ubiquinol Oxidase FAM176 PF14851.1 CDI76258.1 - 7.3 6.2 10.9 7.6 6.2 7.6 1.0 1 0 0 1 1 1 0 FAM176 family Robl_LC7 PF03259.12 CDI76261.1 - 2.1e-24 84.9 0.1 2.3e-24 84.7 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain DUF2141 PF09912.4 CDI76261.1 - 0.11 12.2 0.0 0.46 10.1 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) Abhydrolase_5 PF12695.2 CDI76262.1 - 3.3e-19 69.0 0.0 5.3e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI76262.1 - 1.3e-09 38.3 0.6 0.00035 20.5 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CDI76262.1 - 1.8e-05 24.0 0.3 0.019 14.2 0.0 2.9 2 1 1 3 3 3 1 Prolyl oligopeptidase family DUF818 PF05677.7 CDI76262.1 - 1.9e-05 23.5 0.0 4.7e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FimP PF09766.4 CDI76262.1 - 0.00046 19.3 10.5 0.00072 18.7 7.3 1.3 1 0 0 1 1 1 1 Fms-interacting protein Peptidase_S15 PF02129.13 CDI76262.1 - 0.0022 17.4 12.1 0.0064 15.9 0.0 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.11 CDI76262.1 - 0.0028 17.1 0.0 0.0028 17.1 0.0 2.1 2 1 0 2 2 1 1 Phospholipase/Carboxylesterase TMEM51 PF15345.1 CDI76262.1 - 0.021 14.4 9.5 0.03 14.0 6.6 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Serinc PF03348.10 CDI76262.1 - 0.028 13.1 4.4 0.04 12.6 3.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RED_N PF07808.8 CDI76262.1 - 0.039 13.1 11.9 0.055 12.6 8.2 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Baculo_PP31 PF05311.6 CDI76262.1 - 0.046 12.9 3.4 0.059 12.6 2.4 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) OATP PF03137.15 CDI76262.1 - 0.056 11.4 2.7 0.07 11.1 1.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family OAD_gamma PF04277.8 CDI76262.1 - 0.079 13.3 0.4 0.16 12.3 0.3 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Abhydrolase_1 PF00561.15 CDI76262.1 - 0.079 12.5 0.0 4.9 6.6 0.0 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold Ctr PF04145.10 CDI76262.1 - 0.13 12.3 4.3 0.22 11.5 3.0 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Herpes_glycop PF01528.11 CDI76262.1 - 0.17 10.5 2.0 0.27 9.8 1.4 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M HGTP_anticodon2 PF12745.2 CDI76262.1 - 0.18 10.9 6.5 0.27 10.3 4.5 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs EIIBC-GUT_N PF03612.9 CDI76262.1 - 0.23 11.0 3.9 0.34 10.5 2.7 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pex16 PF08610.5 CDI76262.1 - 0.25 10.2 8.1 0.35 9.8 5.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Anoctamin PF04547.7 CDI76262.1 - 0.29 9.7 2.3 0.37 9.3 1.6 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel DLH PF01738.13 CDI76262.1 - 0.36 10.0 0.0 0.36 10.0 0.0 2.3 2 1 0 2 2 2 0 Dienelactone hydrolase family SHR3_chaperone PF08229.6 CDI76262.1 - 0.43 9.5 8.7 0.68 8.8 6.1 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 DDHD PF02862.12 CDI76262.1 - 0.46 10.2 7.1 0.66 9.7 5.0 1.1 1 0 0 1 1 1 0 DDHD domain FAM176 PF14851.1 CDI76262.1 - 0.48 10.0 4.6 0.79 9.3 3.2 1.3 1 0 0 1 1 1 0 FAM176 family Oleosin PF01277.12 CDI76262.1 - 0.51 9.9 4.9 0.89 9.1 3.4 1.3 1 0 0 1 1 1 0 Oleosin FLO_LFY PF01698.11 CDI76262.1 - 0.59 8.9 7.4 0.82 8.4 5.1 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF4557 PF15101.1 CDI76262.1 - 0.64 9.8 19.1 0.91 9.3 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Peptidase_S49_N PF08496.5 CDI76262.1 - 0.66 9.7 7.5 1 9.1 5.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peroxin-13_N PF04088.8 CDI76262.1 - 0.71 9.8 4.4 1.1 9.1 3.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Sec62 PF03839.11 CDI76262.1 - 0.87 8.9 4.4 1.2 8.4 3.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Rpp20 PF12328.3 CDI76262.1 - 0.88 9.2 10.0 1.4 8.5 6.9 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P AUX_IAA PF02309.11 CDI76262.1 - 1 9.0 7.2 1.5 8.5 5.0 1.2 1 0 0 1 1 1 0 AUX/IAA family DUF1764 PF08576.5 CDI76262.1 - 1.1 10.0 12.3 2.1 9.1 8.5 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Bap31 PF05529.7 CDI76262.1 - 1.6 8.1 10.6 2.5 7.5 7.3 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Band_3_cyto PF07565.8 CDI76262.1 - 1.7 8.0 8.4 2.4 7.5 5.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FemAB PF02388.11 CDI76262.1 - 2.2 6.8 11.3 3 6.4 7.8 1.1 1 0 0 1 1 1 0 FemAB family DUF912 PF06024.7 CDI76262.1 - 2.3 8.3 5.2 3.7 7.6 3.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DDRGK PF09756.4 CDI76262.1 - 2.3 7.5 17.9 3.3 7.0 12.4 1.1 1 0 0 1 1 1 0 DDRGK domain Pap_E4 PF02711.9 CDI76262.1 - 2.6 8.9 9.4 5 8.0 6.5 1.4 1 0 0 1 1 1 0 E4 protein DUF2149 PF09919.4 CDI76262.1 - 2.8 8.1 6.1 4.9 7.3 4.3 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) Hid1 PF12722.2 CDI76262.1 - 2.9 5.4 9.7 3.8 5.0 6.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Folate_carrier PF01770.13 CDI76262.1 - 3 6.2 5.2 4.3 5.7 3.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier Suf PF05843.9 CDI76262.1 - 3.8 7.1 14.2 5.4 6.6 9.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) zf-DHHC PF01529.15 CDI76262.1 - 4.8 6.5 5.9 5.2 6.4 4.1 1.3 1 1 0 1 1 1 0 DHHC palmitoyltransferase Ycf1 PF05758.7 CDI76262.1 - 5 4.7 10.2 6.5 4.3 7.1 1.0 1 0 0 1 1 1 0 Ycf1 AIF_C PF14721.1 CDI76262.1 - 6.2 7.0 8.5 9.8 6.4 5.9 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Endonuclease_NS PF01223.18 CDI76263.1 - 9.3e-18 64.6 0.0 1.5e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease RRM_1 PF00076.17 CDI76264.1 - 0.0071 15.9 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76264.1 - 0.34 10.9 0.0 0.63 10.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SNase PF00565.12 CDI76265.1 - 5.5e-09 36.2 0.0 0.00012 22.3 0.0 2.6 2 0 0 2 2 2 2 Staphylococcal nuclease homologue DUF605 PF04652.11 CDI76265.1 - 5 6.4 17.1 2.6 7.3 0.7 2.3 2 0 0 2 2 2 0 Vta1 like Rhodanese PF00581.15 CDI76266.1 - 8.5e-19 67.9 0.0 3.4e-06 27.3 0.0 3.6 3 1 0 3 3 3 3 Rhodanese-like domain Med15 PF09606.5 CDI76266.1 - 0.00024 19.4 27.8 0.0082 14.4 6.9 2.3 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3801 PF12687.2 CDI76266.1 - 0.042 13.4 3.8 1.1 8.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) Spore_III_AB PF09548.5 CDI76266.1 - 0.21 11.3 5.4 0.34 10.6 1.1 2.5 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) PAT1 PF09770.4 CDI76266.1 - 0.93 7.6 34.3 1.1 7.3 13.5 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.1 CDI76266.1 - 9.9 6.4 9.9 11 6.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain Med15 PF09606.5 CDI76267.1 - 0.47 8.5 47.9 0.17 10.0 31.0 1.7 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hid1 PF12722.2 CDI76267.1 - 1.2 6.7 6.7 1.5 6.3 4.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RabGAP-TBC PF00566.13 CDI76268.1 - 4.3e-05 23.0 0.1 4.3e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF755 PF05501.6 CDI76268.1 - 0.033 14.2 19.2 0.054 13.5 13.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) XOO_2897-deam PF14440.1 CDI76268.1 - 0.035 13.7 1.9 0.073 12.7 1.3 1.5 1 1 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase DUF2217 PF10265.4 CDI76268.1 - 0.051 12.3 7.5 0.064 12.0 5.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Med15 PF09606.5 CDI76268.1 - 0.084 11.0 20.9 0.1 10.7 14.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI76268.1 - 0.092 10.4 6.4 0.11 10.2 4.4 1.0 1 0 0 1 1 1 0 Ycf1 SpoIIIAH PF12685.2 CDI76268.1 - 0.31 10.5 9.2 0.41 10.1 6.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein SAGA-Tad1 PF12767.2 CDI76268.1 - 1.2 8.7 14.8 1.6 8.3 10.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF2071 PF09844.4 CDI76268.1 - 1.2 8.4 4.1 0.28 10.5 0.6 1.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (COG2071) DNA_pol_viral_N PF00242.12 CDI76268.1 - 1.8 7.5 13.5 2.5 7.0 9.4 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain eIF-3_zeta PF05091.7 CDI76268.1 - 8.3 4.9 16.3 11 4.4 11.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDRGK PF09756.4 CDI76268.1 - 9.2 5.6 17.3 14 5.0 12.0 1.2 1 0 0 1 1 1 0 DDRGK domain NPR3 PF03666.8 CDI76268.1 - 9.3 4.6 13.2 12 4.2 9.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Shadoo PF14999.1 CDI76269.1 - 0.0073 16.1 0.4 0.0073 16.1 0.3 4.3 1 1 2 3 3 3 1 Shadow of prion protein, neuroprotective Serinc PF03348.10 CDI76269.1 - 0.057 12.1 0.4 0.084 11.5 0.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) RAB3GAP2_N PF14655.1 CDI76269.1 - 0.21 10.5 2.9 0.3 10.0 2.0 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pribosyltran PF00156.22 CDI76269.1 - 0.24 11.1 0.1 0.24 11.1 0.0 2.2 2 1 1 3 3 3 0 Phosphoribosyl transferase domain Ctr PF04145.10 CDI76269.1 - 4.2 7.4 5.8 0.31 11.0 0.1 2.0 2 1 0 2 2 2 0 Ctr copper transporter family AIRS_C PF02769.17 CDI76271.1 - 4.1e-16 59.3 2.2 1.1e-11 45.0 1.0 2.6 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain Pyr_redox PF00070.22 CDI76271.1 - 5.4e-08 33.1 0.3 0.018 15.4 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AIRS PF00586.19 CDI76271.1 - 1.7e-07 31.3 0.0 1.7e-07 31.3 0.0 3.0 3 1 1 4 4 4 1 AIR synthase related protein, N-terminal domain FAP PF07174.6 CDI76272.1 - 2.3 7.4 14.4 2.4 7.3 10.0 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) ORC6 PF05460.8 CDI76272.1 - 8.9 5.2 10.1 9.7 5.1 7.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Peptidase_S15 PF02129.13 CDI76273.1 - 0.37 10.1 9.3 0.68 9.3 3.4 2.3 3 0 0 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Cons_hypoth95 PF03602.10 CDI76274.1 - 2.4e-29 102.0 0.1 4.5e-25 88.0 0.0 3.0 2 1 1 3 3 3 2 Conserved hypothetical protein 95 Methyltransf_26 PF13659.1 CDI76274.1 - 1.9e-10 40.7 0.0 1.9e-10 40.7 0.0 3.0 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI76274.1 - 0.00011 21.8 0.0 0.00028 20.4 0.0 1.6 1 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDI76274.1 - 0.0011 18.4 0.6 0.01 15.2 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_18 PF12847.2 CDI76274.1 - 0.0025 18.3 0.0 0.0063 17.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Rotamase_2 PF13145.1 CDI76274.1 - 0.02 15.4 0.8 0.02 15.4 0.5 2.5 2 0 0 2 2 2 0 PPIC-type PPIASE domain PrmA PF06325.8 CDI76274.1 - 0.037 13.1 0.0 0.068 12.2 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF2146 PF10220.4 CDI76274.1 - 1 7.2 13.6 1.7 6.5 9.5 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Inositol_P PF00459.20 CDI76275.1 - 1.1e-14 54.4 6.8 0.00026 20.3 0.1 4.7 3 2 1 4 4 4 3 Inositol monophosphatase family Ctr PF04145.10 CDI76275.1 - 0.88 9.6 3.4 11 6.0 0.3 3.1 3 0 0 3 3 3 0 Ctr copper transporter family BRF1 PF07741.8 CDI76275.1 - 2.9 8.1 14.0 0.88 9.8 1.1 4.1 4 0 0 4 4 4 0 Brf1-like TBP-binding domain DUF3337 PF11816.3 CDI76276.1 - 0.26 10.6 31.2 0.32 10.3 21.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Ebola_NP PF05505.7 CDI76276.1 - 0.43 8.5 29.7 0.5 8.3 20.6 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Utp14 PF04615.8 CDI76276.1 - 0.81 7.7 54.3 1.1 7.3 37.7 1.0 1 0 0 1 1 1 0 Utp14 protein MIP-T3 PF10243.4 CDI76276.1 - 1.9 6.8 60.5 2.6 6.3 42.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF966 PF06136.8 CDI76276.1 - 3.9 6.7 40.4 5.2 6.4 28.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) AvrE PF11725.3 CDI76276.1 - 4.3 4.2 38.1 4.8 4.0 26.4 1.0 1 0 0 1 1 1 0 Pathogenicity factor PLRV_ORF5 PF01690.12 CDI76276.1 - 5.5 6.0 33.8 7.5 5.5 23.4 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Parvo_coat PF00740.13 CDI76276.1 - 5.6 5.7 26.1 6.6 5.5 18.1 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Nop53 PF07767.6 CDI76276.1 - 7.1 5.4 53.9 9.1 5.1 37.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PAT1 PF09770.4 CDI76276.1 - 7.6 4.6 53.2 8.1 4.5 36.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RRM_1 PF00076.17 CDI76277.1 - 1.5e-12 46.9 0.1 7.2e-12 44.7 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76277.1 - 9.5e-12 44.7 0.1 2.1e-10 40.4 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76277.1 - 0.071 12.9 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Adaptin_N PF01602.15 CDI76278.1 - 2.7e-17 62.3 2.2 9.4e-10 37.4 0.1 3.6 2 1 2 4 4 4 3 Adaptin N terminal region B2-adapt-app_C PF09066.5 CDI76278.1 - 5.1e-05 23.1 0.4 9.8e-05 22.2 0.3 1.4 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Phostensin_N PF13916.1 CDI76278.1 - 0.0035 17.2 0.7 0.0062 16.4 0.5 1.4 1 0 0 1 1 1 1 PP1-regulatory protein, Phostensin N-terminal Ofd1_CTDD PF10637.4 CDI76278.1 - 0.049 12.7 0.1 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term TSA PF03249.8 CDI76278.1 - 0.09 11.3 1.1 0.11 11.0 0.8 1.1 1 0 0 1 1 1 0 Type specific antigen DUF945 PF06097.6 CDI76278.1 - 0.43 9.2 4.1 1.3 7.7 1.7 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF945) Coq4 PF05019.8 CDI76279.1 - 1e-45 155.3 0.0 1.3e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Ribosomal_60s PF00428.14 CDI76279.1 - 4.3 7.7 10.7 3.9 7.9 6.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Serinc PF03348.10 CDI76281.1 - 1.6 7.3 11.7 2.1 6.9 8.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RAP PF08373.5 CDI76283.1 - 2.1e-21 75.4 0.2 2.1e-21 75.4 0.2 2.7 3 0 0 3 3 3 1 RAP domain SR-25 PF10500.4 CDI76283.1 - 0.0065 15.9 8.7 0.0065 15.9 6.1 3.6 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein PAT1 PF09770.4 CDI76283.1 - 0.52 8.4 103.7 0.0034 15.7 14.3 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Anticodon_1 PF08264.8 CDI76285.1 - 2.3e-14 53.4 0.1 3.6e-14 52.7 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 CDI76285.1 - 0.057 12.5 0.0 0.2 10.7 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Suf PF05843.9 CDI76285.1 - 0.064 12.9 1.9 0.097 12.3 1.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1725 PF08333.6 CDI76285.1 - 0.13 11.6 0.1 0.37 10.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) tRNA-synt_1 PF00133.17 CDI76286.1 - 1.5e-07 29.7 0.0 2.4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) TSA PF03249.8 CDI76286.1 - 0.058 11.9 2.3 0.083 11.4 1.6 1.1 1 0 0 1 1 1 0 Type specific antigen Pterin_bind PF00809.17 CDI76287.1 - 7.7e-64 214.9 0.0 1.2e-63 214.3 0.0 1.3 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 CDI76287.1 - 1.6e-22 79.6 0.7 6.5e-20 71.1 0.5 2.6 1 1 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) ClpS PF02617.12 CDI76289.1 - 1.5e-13 50.2 0.4 6.5e-13 48.2 0.1 2.0 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS BMF PF15185.1 CDI76289.1 - 0.043 13.1 0.2 0.058 12.6 0.2 1.2 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis Atrophin-1 PF03154.10 CDI76289.1 - 0.55 8.2 3.4 0.63 8.1 2.4 1.0 1 0 0 1 1 1 0 Atrophin-1 family cNMP_binding PF00027.24 CDI76290.1 - 5.6e-13 48.5 0.0 1.8e-06 27.6 0.0 2.6 1 1 1 2 2 2 2 Cyclic nucleotide-binding domain AAA_23 PF13476.1 CDI76290.1 - 0.0036 17.6 11.1 0.054 13.8 1.1 2.7 2 0 0 2 2 2 2 AAA domain DUF342 PF03961.8 CDI76290.1 - 6.9 4.9 21.4 0.5 8.7 2.9 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF342) DUF3458 PF11940.3 CDI76292.1 - 2.2e-119 398.5 0.6 4e-119 397.7 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Peptidase_M1 PF01433.15 CDI76292.1 - 8.3e-63 212.7 0.0 1.2e-62 212.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 Peptidase_MA_2 PF13485.1 CDI76292.1 - 1.1e-15 57.7 0.1 2.8e-15 56.4 0.1 1.6 1 0 0 1 1 1 1 Peptidase MA superfamily zf-DNL PF05180.7 CDI76295.1 - 3.2e-28 97.2 0.8 4.6e-28 96.7 0.5 1.2 1 0 0 1 1 1 1 DNL zinc finger zf-CSL PF05207.8 CDI76295.1 - 0.014 14.8 0.6 0.025 14.0 0.4 1.3 1 0 0 1 1 1 0 CSL zinc finger TFIIS_C PF01096.13 CDI76295.1 - 0.047 13.3 3.2 0.11 12.1 0.6 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Methyltransf_11 PF08241.7 CDI76296.1 - 8.4e-07 29.3 0.0 3.2e-06 27.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI76296.1 - 0.00023 20.9 0.1 0.00038 20.2 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI76296.1 - 0.00025 21.4 0.0 0.00069 20.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI76296.1 - 0.012 15.9 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 CDI76296.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Med15 PF09606.5 CDI76296.1 - 3.4 5.7 18.3 5.5 5.0 12.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RRM_1 PF00076.17 CDI76298.1 - 6.7e-16 57.6 0.0 1e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76298.1 - 1.4e-14 53.8 0.0 2.1e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76298.1 - 3.5e-09 36.3 0.2 5.7e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.8 CDI76298.1 - 7.7e-06 26.3 0.0 2.6e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 SPOC domain BRAP2 PF07576.7 CDI76298.1 - 0.032 13.8 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 BRCA1-associated protein 2 SET_assoc PF11767.3 CDI76298.1 - 0.18 11.1 0.1 0.29 10.4 0.1 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Leo1 PF04004.8 CDI76300.1 - 8.5e-11 41.8 0.6 1.9e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 Leo1-like protein CAF-1_p150 PF11600.3 CDI76301.1 - 0.081 12.2 26.9 0.1 11.9 18.7 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF1510 PF07423.6 CDI76301.1 - 0.3 10.4 28.8 0.36 10.1 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 CDI76301.1 - 2.2 6.2 28.4 2.4 6.1 19.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SprA-related PF12118.3 CDI76301.1 - 3.7 6.8 55.5 4.6 6.4 38.4 1.1 1 0 0 1 1 1 0 SprA-related family Asp-B-Hydro_N PF05279.6 CDI76301.1 - 4 7.2 23.1 4.6 7.0 16.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Rtf2 PF04641.7 CDI76301.1 - 6.1 5.9 22.5 7.2 5.7 15.6 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger RR_TM4-6 PF06459.7 CDI76301.1 - 6.2 6.6 23.1 9.8 5.9 16.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tropomyosin PF00261.15 CDI76302.1 - 0.00033 19.8 20.6 0.00033 19.8 14.2 4.1 3 1 1 4 4 4 1 Tropomyosin Baculo_PEP_C PF04513.7 CDI76302.1 - 0.0038 17.0 22.2 0.0092 15.8 0.1 4.4 2 2 2 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.4 CDI76302.1 - 0.0046 16.8 14.7 0.0046 16.8 10.2 5.2 3 1 3 6 6 6 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.16 CDI76302.1 - 0.098 12.1 62.9 0.4 10.0 11.8 3.0 1 1 1 2 2 2 0 Intermediate filament protein Reo_sigmaC PF04582.7 CDI76302.1 - 0.82 8.7 14.2 0.026 13.7 1.4 3.1 1 1 1 3 3 3 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 CDI76302.1 - 0.91 7.8 50.4 5.3 5.3 18.3 3.1 1 1 1 2 2 2 0 AAA domain FH2 PF02181.18 CDI76302.1 - 3.9 6.2 37.5 2.4 6.9 4.3 4.1 2 2 1 3 3 3 0 Formin Homology 2 Domain HEAT_2 PF13646.1 CDI76304.1 - 1.7e-07 31.4 47.6 1.4e-05 25.2 0.4 5.1 1 1 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.11 CDI76304.1 - 2.1e-05 24.5 30.5 0.23 12.0 0.0 7.9 6 1 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.17 CDI76304.1 - 0.001 18.9 7.2 4.5 7.6 0.1 5.6 5 1 1 6 6 6 3 HEAT repeat Cohesin_HEAT PF12765.2 CDI76304.1 - 0.034 14.0 0.2 0.28 11.1 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Arm PF00514.18 CDI76304.1 - 2.3 8.1 5.8 2.2 8.2 0.2 3.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Pex16 PF08610.5 CDI76306.1 - 4.2e-23 81.8 0.6 4.2e-23 81.8 0.4 3.2 2 1 0 2 2 2 1 Peroxisomal membrane protein (Pex16) PARP PF00644.15 CDI76307.1 - 9.3e-11 41.5 0.0 6.1e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain MA3 PF02847.12 CDI76308.1 - 4e-33 113.4 2.9 2.8e-11 43.0 0.0 3.2 3 0 0 3 3 3 3 MA3 domain B56 PF01603.15 CDI76308.1 - 0.12 10.9 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) Lipase_3 PF01764.20 CDI76310.1 - 3.3e-17 62.4 0.0 5.3e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CDI76310.1 - 0.031 14.0 0.0 0.085 12.6 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.17 CDI76310.1 - 0.04 13.6 0.0 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 Cutinase CutA1 PF03091.10 CDI76311.1 - 6.6e-34 115.6 0.8 7.7e-34 115.4 0.5 1.0 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein DZF PF07528.9 CDI76311.1 - 0.0041 16.5 0.3 0.0049 16.3 0.2 1.1 1 0 0 1 1 1 1 DZF domain AAT PF03417.11 CDI76311.1 - 0.005 16.3 0.0 0.0057 16.1 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase AsnC_trans_reg PF01037.16 CDI76311.1 - 0.068 12.8 0.3 0.24 11.1 0.1 1.9 2 0 0 2 2 2 0 AsnC family SseB_C PF14581.1 CDI76311.1 - 0.079 12.8 0.1 0.089 12.6 0.1 1.2 1 0 0 1 1 1 0 SseB protein C-terminal domain Arg_repressor_C PF02863.13 CDI76311.1 - 0.088 12.2 0.4 0.33 10.4 0.1 2.0 2 1 0 2 2 2 0 Arginine repressor, C-terminal domain vATP-synt_E PF01991.13 CDI76312.1 - 3.5e-57 192.8 1.2 4.3e-57 192.6 0.8 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4239 PF14023.1 CDI76312.1 - 0.024 14.0 4.1 0.049 12.9 2.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) PDCD2_C PF04194.8 CDI76313.1 - 4.8e-35 120.5 0.0 8e-35 119.8 0.0 1.3 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Lar_restr_allev PF14354.1 CDI76313.1 - 0.06 13.6 0.2 0.06 13.6 0.2 2.4 3 0 0 3 3 3 0 Restriction alleviation protein Lar Kelch_3 PF13415.1 CDI76314.1 - 1.4e-20 72.8 5.6 4.3e-07 29.9 0.1 5.3 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI76314.1 - 4.3e-17 61.6 1.9 0.0016 18.3 0.0 5.8 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.1 CDI76314.1 - 7e-16 57.7 8.1 6.3e-06 25.8 0.1 5.8 5 0 0 5 5 5 4 Galactose oxidase, central domain HATPase_c_3 PF13589.1 CDI76314.1 - 8.8e-10 38.3 0.0 1.8e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_1 PF01344.20 CDI76314.1 - 5.7e-05 22.5 0.1 1.5 8.4 0.0 4.0 4 0 0 4 4 4 2 Kelch motif HATPase_c PF02518.21 CDI76314.1 - 0.00018 21.1 0.0 0.00036 20.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_6 PF13964.1 CDI76314.1 - 0.00048 20.1 3.8 0.2 11.8 0.1 4.6 3 1 2 5 5 5 1 Kelch motif Ribosomal_S3Ae PF01015.13 CDI76315.1 - 1.3e-80 269.3 0.4 1.5e-80 269.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Kelch_4 PF13418.1 CDI76318.1 - 8.1e-36 121.5 12.4 7.9e-09 35.1 0.0 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 CDI76318.1 - 5.1e-30 102.9 7.9 2.4e-07 30.7 0.0 8.0 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI76318.1 - 3e-28 97.2 3.5 1.7e-05 24.6 0.1 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 CDI76318.1 - 4.1e-24 83.6 4.3 1.4e-06 28.2 0.0 6.0 5 1 1 6 6 6 4 Kelch motif DUF4110 PF13422.1 CDI76318.1 - 1.4e-15 56.8 0.8 1.4e-15 56.8 0.6 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4110) Kelch_1 PF01344.20 CDI76318.1 - 2.3e-13 49.4 15.4 3.4e-05 23.2 0.0 6.8 7 1 0 7 7 7 2 Kelch motif Kelch_2 PF07646.10 CDI76318.1 - 5.6e-12 44.9 19.0 3e-05 23.5 0.1 6.9 6 2 0 6 6 6 4 Kelch motif CUE PF02845.11 CDI76319.1 - 0.0092 15.4 0.0 0.024 14.1 0.0 1.8 1 0 0 1 1 1 1 CUE domain CS PF04969.11 CDI76320.1 - 7.3e-05 23.2 0.0 0.00013 22.4 0.0 1.4 1 0 0 1 1 1 1 CS domain SGS PF05002.10 CDI76320.1 - 0.00038 20.1 0.1 0.00067 19.3 0.1 1.3 1 0 0 1 1 1 1 SGS domain Siah-Interact_N PF09032.6 CDI76320.1 - 0.034 14.1 0.1 0.07 13.1 0.1 1.5 1 0 0 1 1 1 0 Siah interacting protein, N terminal Ribosomal_S19 PF00203.16 CDI76321.1 - 2.6e-27 94.2 0.0 3.5e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 LRR_4 PF12799.2 CDI76323.1 - 5.1e-22 77.0 19.7 2.6e-06 26.9 0.3 5.4 4 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI76323.1 - 3.5e-13 49.0 21.1 5.4e-08 32.4 2.1 4.3 3 1 0 3 3 3 3 Leucine rich repeat LRR_9 PF14580.1 CDI76323.1 - 6.3e-12 45.3 5.7 1.5e-05 24.6 0.0 2.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.28 CDI76323.1 - 4.6e-10 38.1 19.5 1 9.6 0.0 8.2 7 1 1 8 8 8 4 Leucine Rich Repeat LRR_7 PF13504.1 CDI76323.1 - 2.5e-06 26.7 21.3 6.3 7.4 0.1 8.3 6 2 2 8 8 8 4 Leucine rich repeat LRR_6 PF13516.1 CDI76323.1 - 3.4e-06 26.5 15.4 0.91 9.7 0.0 7.3 7 1 1 8 8 8 3 Leucine Rich repeat Surp PF01805.15 CDI76324.1 - 2.1e-07 30.4 0.1 7.7e-07 28.6 0.0 1.9 1 0 0 1 1 1 1 Surp module Cwf_Cwc_15 PF04889.7 CDI76324.1 - 0.0022 17.7 15.8 0.0022 17.7 11.0 4.1 4 1 0 4 4 4 1 Cwf15/Cwc15 cell cycle control protein PA26 PF04636.8 CDI76324.1 - 0.013 14.2 4.4 0.032 12.9 3.1 1.6 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SHS2_Rpb7-N PF03876.12 CDI76325.1 - 2.5e-13 49.9 0.1 4.3e-13 49.1 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 CDI76325.1 - 1e-06 28.7 0.0 1.9e-06 27.8 0.0 1.4 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 CDI76325.1 - 0.026 14.7 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 polyprenyl_synt PF00348.12 CDI76326.1 - 8.5e-30 103.4 2.5 5.5e-15 54.9 0.5 4.2 3 1 0 3 3 3 3 Polyprenyl synthetase adh_short PF00106.20 CDI76328.1 - 3.1e-15 56.4 0.2 8.8e-15 55.0 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CDI76328.1 - 3.3e-07 30.1 0.0 1e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 KR domain PsbM PF05151.7 CDI76328.1 - 0.13 11.8 0.7 0.25 10.9 0.5 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre M protein (PsbM) B-block_TFIIIC PF04182.7 CDI76329.1 - 5.4e-10 38.9 0.0 4.5e-09 36.0 0.0 2.3 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC Suf PF05843.9 CDI76331.1 - 1.4 8.6 12.9 3.7 7.1 1.1 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) FAM176 PF14851.1 CDI76332.1 - 0.014 15.0 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 FAM176 family Trp_oprn_chp PF09534.5 CDI76332.1 - 0.019 14.5 0.3 0.21 11.1 0.0 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2681 PF10883.3 CDI76332.1 - 0.029 14.5 2.4 0.092 12.9 1.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Syndecan PF01034.15 CDI76332.1 - 0.057 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain HSP70 PF00012.15 CDI76334.1 - 7.5e-99 331.2 8.3 9.8e-99 330.9 5.7 1.1 1 0 0 1 1 1 1 Hsp70 protein HBS1_N PF08938.5 CDI76334.1 - 0.0071 16.4 4.6 0.0091 16.0 2.4 1.7 1 1 0 1 1 1 1 HBS1 N-terminus Tetraspannin PF00335.15 CDI76334.1 - 0.021 14.1 0.6 0.032 13.5 0.4 1.3 1 0 0 1 1 1 0 Tetraspanin family GBP_C PF02841.9 CDI76334.1 - 0.064 12.4 15.0 0.16 11.1 10.4 1.7 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF3439 PF11921.3 CDI76334.1 - 6.1 6.6 9.6 15 5.3 6.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Secretin_N_2 PF07655.8 CDI76334.1 - 6.8 7.1 21.7 22 5.5 15.0 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Borrelia_P83 PF05262.6 CDI76336.1 - 0.00012 20.5 8.8 0.00014 20.3 6.1 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein Zip PF02535.17 CDI76336.1 - 0.017 14.1 0.3 0.033 13.1 0.2 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter Shadoo PF14999.1 CDI76336.1 - 0.055 13.3 9.1 0.11 12.3 6.3 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF2215 PF10225.4 CDI76336.1 - 0.08 12.3 3.0 0.13 11.7 2.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) COX4_pro PF03626.9 CDI76336.1 - 2.2 8.4 6.8 1.2 9.3 0.8 2.6 2 1 0 2 2 2 0 Prokaryotic Cytochrome C oxidase subunit IV Usp PF00582.21 CDI76336.1 - 2.5 8.2 5.3 5.6 7.1 3.7 1.6 1 0 0 1 1 1 0 Universal stress protein family Med15 PF09606.5 CDI76336.1 - 2.6 6.1 52.0 3.2 5.8 36.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI76336.1 - 4.4 5.4 37.8 5.5 5.1 26.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-C2HC_2 PF13913.1 CDI76337.1 - 1.9e-08 33.7 19.7 1.7e-05 24.3 5.0 2.6 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Mito_carr PF00153.22 CDI76338.1 - 0.00055 19.5 19.1 0.071 12.8 0.0 5.1 5 1 0 5 5 5 3 Mitochondrial carrier protein Kinesin PF00225.18 CDI76339.1 - 1.7e-50 171.6 0.2 1.7e-50 171.6 0.1 5.0 2 1 1 3 3 3 1 Kinesin motor domain FHA PF00498.21 CDI76339.1 - 2.1e-07 30.9 0.0 5.5e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 FHA domain Ribosomal_60s PF00428.14 CDI76339.1 - 0.00064 20.0 3.8 0.00064 20.0 2.7 8.9 7 1 1 8 8 8 2 60s Acidic ribosomal protein OmpH PF03938.9 CDI76340.1 - 0.45 10.4 16.7 0.61 10.0 7.5 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) UMP1 PF05348.6 CDI76340.1 - 0.5 10.3 6.6 1.1 9.1 4.6 1.7 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 CAF-1_p150 PF11600.3 CDI76340.1 - 0.61 9.4 23.7 0.086 12.2 8.0 2.3 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Peptidase_S64 PF08192.6 CDI76340.1 - 1.2 7.4 14.8 1.5 7.0 10.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4407 PF14362.1 CDI76340.1 - 1.6 7.6 12.0 3.5 6.5 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Rsc14 PF08586.5 CDI76340.1 - 1.9 9.0 5.3 0.29 11.6 0.5 1.9 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit DUF3801 PF12687.2 CDI76340.1 - 2.6 7.5 9.6 0.57 9.7 3.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) BRF1 PF07741.8 CDI76340.1 - 2.6 8.3 13.5 1.6 8.9 0.9 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF912 PF06024.7 CDI76340.1 - 2.9 7.9 5.2 15 5.7 0.8 2.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) 60KD_IMP PF02096.15 CDI76340.1 - 3.6 7.1 10.4 2.1 7.9 5.6 1.7 2 0 0 2 2 2 0 60Kd inner membrane protein RskA PF10099.4 CDI76340.1 - 4.3 7.0 21.3 1.7e+02 1.8 14.8 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA UPF0561 PF10573.4 CDI76340.1 - 8.1 6.3 9.8 19 5.0 3.8 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 SR-25 PF10500.4 CDI76340.1 - 9.9 5.5 40.1 0.18 11.2 5.3 2.6 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Peptidase_M48 PF01435.13 CDI76342.1 - 3.5e-44 151.0 0.0 2.3e-43 148.3 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M48 ATP_bind_1 PF03029.12 CDI76344.1 - 0.00019 21.0 4.7 0.018 14.5 0.6 3.0 3 1 1 4 4 4 2 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 CDI76344.1 - 0.00047 20.1 0.0 0.0014 18.5 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.17 CDI76344.1 - 0.0023 16.8 1.4 0.0026 16.6 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain SseC PF04888.7 CDI76344.1 - 0.0026 17.1 21.7 0.0026 17.1 15.0 3.0 3 0 0 3 3 3 1 Secretion system effector C (SseC) like family AAA_17 PF13207.1 CDI76344.1 - 0.004 17.9 0.2 0.013 16.2 0.1 1.8 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 CDI76344.1 - 0.0083 15.8 0.0 0.024 14.3 0.0 1.7 1 1 0 1 1 1 1 NTPase AAA_16 PF13191.1 CDI76344.1 - 0.011 15.7 0.4 0.011 15.7 0.3 2.8 2 1 0 2 2 2 0 AAA ATPase domain ArgK PF03308.11 CDI76344.1 - 0.013 14.2 0.2 0.32 9.7 0.0 2.2 2 0 0 2 2 2 0 ArgK protein NACHT PF05729.7 CDI76344.1 - 0.02 14.5 0.0 0.049 13.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 CDI76344.1 - 0.031 13.2 0.2 0.031 13.2 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 CDI76344.1 - 0.035 14.2 1.6 0.09 12.9 0.2 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 CDI76344.1 - 0.037 13.4 0.2 0.2 11.0 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 CDI76344.1 - 0.044 14.1 0.7 0.075 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 CDI76344.1 - 0.048 13.1 0.4 0.048 13.1 0.3 2.7 2 1 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.1 CDI76344.1 - 0.093 12.6 1.8 0.1 12.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain ATP_bind_2 PF03668.10 CDI76344.1 - 0.094 11.7 0.2 0.2 10.6 0.2 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family AAA_14 PF13173.1 CDI76344.1 - 0.48 10.3 0.0 0.48 10.3 0.0 2.8 3 1 0 3 3 3 0 AAA domain DUF258 PF03193.11 CDI76344.1 - 0.52 9.4 5.4 1.6 7.9 3.8 1.8 1 1 0 1 1 1 0 Protein of unknown function, DUF258 Septin PF00735.13 CDI76344.1 - 1.1 8.2 4.2 2.7 6.9 2.9 1.7 1 1 0 1 1 1 0 Septin Dynamin_N PF00350.18 CDI76344.1 - 1.1 9.1 15.2 0.048 13.4 5.5 2.4 2 1 0 2 2 2 0 Dynamin family AAA PF00004.24 CDI76344.1 - 5.6 7.1 6.6 1.4 9.1 0.9 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Kinesin PF00225.18 CDI76346.1 - 2.1e-53 181.2 0.8 2.1e-53 181.2 0.6 1.9 2 0 0 2 2 2 1 Kinesin motor domain DUF89 PF01937.14 CDI76346.1 - 0.11 11.2 2.6 0.18 10.5 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 OmpH PF03938.9 CDI76346.1 - 0.22 11.4 14.3 0.32 10.9 9.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) LUC7 PF03194.10 CDI76346.1 - 0.44 10.0 7.9 0.29 10.6 4.1 1.7 2 0 0 2 2 2 0 LUC7 N_terminus Cytochrom_B562 PF07361.6 CDI76346.1 - 0.67 10.3 8.7 0.47 10.9 4.7 1.7 2 0 0 2 2 2 0 Cytochrome b562 Presenilin PF01080.12 CDI76346.1 - 4 6.1 5.7 5.3 5.7 4.0 1.1 1 0 0 1 1 1 0 Presenilin PBP_sp32 PF07222.7 CDI76346.1 - 6.5 5.8 10.7 10 5.1 7.4 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 F-protein PF00469.15 CDI76346.1 - 8.6 5.6 9.3 12 5.1 6.4 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Methyltransf_31 PF13847.1 CDI76350.1 - 1.6e-05 24.5 0.0 1.7e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI76350.1 - 0.00061 20.2 0.0 0.0011 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI76350.1 - 0.0034 17.9 0.0 0.0051 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI76350.1 - 0.012 16.0 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 CDI76350.1 - 0.021 14.5 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain SLX9 PF15341.1 CDI76351.1 - 3.2e-07 30.8 5.1 3.2e-07 30.8 3.5 2.5 2 1 1 3 3 3 1 Ribosome biogenesis protein SLX9 RRN9 PF10680.4 CDI76351.1 - 0.02 14.6 0.3 0.039 13.6 0.2 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor PAT1 PF09770.4 CDI76352.1 - 0.0018 16.6 38.5 0.0018 16.6 26.7 2.2 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 Chorion_2 PF03964.10 CDI76353.1 - 0.0015 18.9 3.7 0.0015 18.9 2.6 24.5 13 7 9 23 23 23 1 Chorion family 2 zf-DHHC PF01529.15 CDI76353.1 - 0.81 9.0 3.9 2.6 7.3 0.1 2.8 3 0 0 3 3 3 0 DHHC palmitoyltransferase DUF1117 PF06547.7 CDI76353.1 - 8.7 6.4 21.1 15 5.7 1.3 5.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1117) Glyco_hydro_47 PF01532.15 CDI76356.1 - 0.48 9.0 5.8 0.48 9.0 4.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 47 tRNA-synt_2c PF01411.14 CDI76356.1 - 7 4.8 10.0 7.7 4.6 6.9 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (A) ICL PF00463.16 CDI76357.1 - 1.1 7.4 5.2 0.86 7.7 3.0 1.3 1 1 0 1 1 1 0 Isocitrate lyase family OrfB_Zn_ribbon PF07282.6 CDI76357.1 - 1.3 8.7 7.6 2.8 7.6 0.1 2.7 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Exonuc_VII_L PF02601.10 CDI76357.1 - 2.3 7.3 14.0 3.2 6.8 9.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Het-C PF07217.6 CDI76357.1 - 6.4 4.8 7.4 11 4.0 5.2 1.3 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Ribosomal_60s PF00428.14 CDI76358.1 - 0.18 12.1 7.8 0.29 11.5 5.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3141 PF11339.3 CDI76358.1 - 0.48 8.7 18.4 0.5 8.6 12.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) TT_ORF1 PF02956.9 CDI76358.1 - 0.56 8.6 19.8 0.71 8.2 13.8 1.0 1 0 0 1 1 1 0 TT viral orf 1 GAGA_bind PF06217.7 CDI76358.1 - 0.72 9.7 27.4 0.8 9.6 19.0 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Med15 PF09606.5 CDI76358.1 - 1.1 7.3 73.0 1.3 7.1 50.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI76358.1 - 5.2 5.1 59.2 5.5 5.0 41.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PCEMA1 PF07418.6 CDI76358.1 - 5.6 6.2 10.4 6.1 6.1 7.2 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 DUF2347 PF09804.4 CDI76358.1 - 6 6.0 16.5 6.7 5.8 11.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF4045 PF13254.1 CDI76358.1 - 8.9 5.4 20.0 9.6 5.3 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DGF-1_C PF11040.3 CDI76359.1 - 2.7 7.9 11.2 0.11 12.3 0.7 3.1 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Tfb2 PF03849.9 CDI76361.1 - 1.5e-36 125.8 1.4 1.7e-24 86.1 0.0 4.1 3 1 0 3 3 3 3 Transcription factor Tfb2 Helicase_C_3 PF13625.1 CDI76361.1 - 0.00011 21.9 0.0 0.00046 19.9 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Pex14_N PF04695.8 CDI76361.1 - 0.75 9.8 30.5 0.032 14.2 7.0 3.9 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1470 PF07336.6 CDI76361.1 - 1.8 8.9 27.6 12 6.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1470) Serglycin PF04360.7 CDI76361.1 - 1.9 8.1 13.4 1.2 8.8 2.3 3.1 2 1 1 3 3 3 0 Serglycin Ndc1_Nup PF09531.5 CDI76361.1 - 3.6 5.9 17.7 0.58 8.5 3.4 2.5 3 0 0 3 3 3 0 Nucleoporin protein Ndc1-Nup Ras PF00071.17 CDI76362.1 - 8.9e-52 174.7 0.4 1.1e-51 174.4 0.3 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI76362.1 - 3.2e-19 69.5 0.0 5.3e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDI76362.1 - 4.3e-11 42.3 0.0 6.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDI76362.1 - 2.9e-07 30.0 0.1 5.4e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI76362.1 - 0.00081 19.3 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDI76362.1 - 0.0071 15.5 0.0 0.01 14.9 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region LAM_C PF12544.3 CDI76366.1 - 0.12 12.4 2.1 0.21 11.6 1.5 1.5 1 0 0 1 1 1 0 Lysine-2,3-aminomutase Ycf1 PF05758.7 CDI76366.1 - 0.27 8.9 7.3 0.32 8.6 5.0 1.1 1 0 0 1 1 1 0 Ycf1 Med15 PF09606.5 CDI76366.1 - 0.58 8.2 36.5 0.71 8.0 25.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Macoilin PF09726.4 CDI76366.1 - 1.7 6.8 10.0 2.2 6.4 6.9 1.2 1 0 0 1 1 1 0 Transmembrane protein PAT1 PF09770.4 CDI76366.1 - 1.7 6.8 29.1 1.9 6.6 20.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 CDI76366.1 - 3.1 5.3 39.1 4.2 4.9 27.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Corona_nucleoca PF00937.13 CDI76367.1 - 0.13 11.1 25.6 0.012 14.5 4.7 2.0 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein RskA PF10099.4 CDI76367.1 - 0.2 11.3 3.8 0.19 11.4 0.6 2.0 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Transposase_22 PF02994.9 CDI76367.1 - 0.52 8.7 7.4 1.1 7.6 0.6 2.0 2 0 0 2 2 2 0 L1 transposable element TFIIA PF03153.8 CDI76367.1 - 0.85 9.4 20.8 1.1 9.0 14.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.7 CDI76367.1 - 0.87 9.2 13.5 0.04 13.6 4.6 1.7 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Anillin PF08174.6 CDI76367.1 - 1.5 8.8 9.8 0.85 9.6 0.2 2.5 2 1 0 2 2 2 0 Cell division protein anillin Herpes_UL87 PF03043.9 CDI76367.1 - 3.7 5.8 10.0 4.6 5.5 6.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family Pam16 PF03656.8 CDI76368.1 - 0.14 11.9 3.8 0.18 11.6 2.6 1.3 1 0 0 1 1 1 0 Pam16 DUF2360 PF10152.4 CDI76368.1 - 0.2 11.9 1.6 0.29 11.4 1.1 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) MSP1_C PF07462.6 CDI76368.1 - 0.66 8.2 4.6 0.62 8.3 3.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF3597 PF12200.3 CDI76368.1 - 1.1 9.6 7.2 1.5 9.1 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) R_equi_Vir PF05526.6 CDI76368.1 - 2.1 7.9 4.5 2.1 7.9 3.1 1.2 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF605 PF04652.11 CDI76369.1 - 0.12 11.7 43.6 0.13 11.6 30.2 1.1 1 0 0 1 1 1 0 Vta1 like DUF3801 PF12687.2 CDI76369.1 - 0.69 9.4 24.3 1.1 8.8 12.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3801) Ribosomal_60s PF00428.14 CDI76370.1 - 0.0065 16.8 6.3 0.0065 16.8 4.4 28.5 17 9 9 26 26 26 5 60s Acidic ribosomal protein zf-HIT PF04438.11 CDI76373.1 - 0.00063 19.3 18.8 0.00095 18.7 13.0 1.3 1 0 0 1 1 1 1 HIT zinc finger Hid1 PF12722.2 CDI76373.1 - 1.7 6.2 34.0 2.8 5.5 23.6 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Methyltransf_18 PF12847.2 CDI76374.1 - 2.2e-11 44.2 0.1 8e-11 42.5 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CDI76374.1 - 1.7e-10 40.5 0.3 1.7e-10 40.5 0.2 2.3 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CDI76374.1 - 3.8e-10 39.4 0.1 3.5e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.1 CDI76374.1 - 3.3e-09 36.5 0.5 8.6e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI76374.1 - 6e-08 32.7 0.3 6e-08 32.7 0.2 4.3 3 1 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI76374.1 - 7.8e-07 29.4 0.2 1.4e-05 25.4 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI76374.1 - 1.7e-06 27.8 1.6 1.2e-05 25.0 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI76374.1 - 3.5e-05 24.0 0.0 0.00016 21.9 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 CDI76374.1 - 0.00038 19.6 0.0 0.00063 18.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB PCMT PF01135.14 CDI76374.1 - 0.00072 19.1 0.1 0.0021 17.6 0.1 1.7 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.10 CDI76374.1 - 0.00083 18.7 0.1 0.00083 18.7 0.1 2.3 3 0 0 3 3 2 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.7 CDI76374.1 - 0.0019 18.6 3.7 0.013 15.9 0.0 3.5 3 1 1 4 4 4 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDI76374.1 - 0.004 16.3 0.0 0.0063 15.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 CDI76374.1 - 0.0046 15.7 0.0 0.0046 15.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) CMAS PF02353.15 CDI76374.1 - 0.0081 15.2 0.0 0.017 14.1 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.4 CDI76374.1 - 0.01 15.2 0.5 0.028 13.8 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Met_10 PF02475.11 CDI76374.1 - 0.016 14.7 0.1 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein RCR PF12273.3 CDI76374.1 - 0.023 15.2 9.9 0.023 15.2 6.8 2.7 2 1 1 3 3 3 0 Chitin synthesis regulation, resistance to Congo red PCIF1_WW PF12237.3 CDI76375.1 - 1.6e-24 86.1 0.8 6e-23 81.0 0.5 3.3 1 1 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain Med15 PF09606.5 CDI76375.1 - 0.0018 16.6 7.7 0.0018 16.6 5.4 7.0 4 2 1 6 6 6 2 ARC105 or Med15 subunit of Mediator complex non-fungal DNA_pol_A_exo1 PF01612.15 CDI76378.1 - 1.9e-06 27.4 0.0 3.2e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease MAR_sialic_bdg PF10564.4 CDI76379.1 - 1.2e-40 137.2 20.4 2.6e-22 78.4 2.5 3.1 3 0 0 3 3 3 3 Sialic-acid binding micronemal adhesive repeat DSL PF01414.14 CDI76379.1 - 1.2 9.2 8.3 1 9.4 0.2 3.0 3 0 0 3 3 3 0 Delta serrate ligand MAR_sialic_bdg PF10564.4 CDI76380.1 - 3.5e-16 58.7 2.9 4.6e-16 58.4 2.0 1.1 1 0 0 1 1 1 1 Sialic-acid binding micronemal adhesive repeat E1_dh PF00676.15 CDI76381.1 - 4.9e-94 314.4 0.0 6.4e-94 314.0 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 CDI76381.1 - 4.1e-11 42.6 0.2 4.1e-11 42.6 0.1 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Transketolase_N PF00456.16 CDI76381.1 - 3.3e-07 29.4 0.0 8.1e-07 28.1 0.0 1.6 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.1 CDI76381.1 - 3.5e-05 22.8 0.0 5.6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DNA_Packaging PF11053.3 CDI76381.1 - 0.088 12.4 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Terminase DNA packaging enzyme PmbA_TldD PF01523.11 CDI76381.1 - 0.098 11.9 0.4 0.19 10.9 0.3 1.4 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Ocnus PF05005.10 CDI76382.1 - 2.2e-18 66.0 0.1 3.7e-18 65.3 0.1 1.3 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) ARD PF03079.9 CDI76383.1 - 0.12 12.2 1.5 0.25 11.3 1.1 1.5 1 0 0 1 1 1 0 ARD/ARD' family Wyosine_form PF08608.7 CDI76384.1 - 1.9e-20 72.7 0.0 4.5e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.16 CDI76384.1 - 4.7e-18 65.8 0.0 8.2e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily CMD PF02627.15 CDI76384.1 - 0.024 14.4 3.5 0.036 13.9 0.1 2.9 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Med15 PF09606.5 CDI76384.1 - 0.13 10.4 26.3 0.19 9.9 3.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DNA_ligase_aden PF01653.13 CDI76385.1 - 1.9e-45 155.1 0.1 8.4e-14 51.2 0.0 6.9 6 1 1 7 7 7 6 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.11 CDI76385.1 - 2.5e-23 81.5 0.1 4.9e-23 80.5 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain B56 PF01603.15 CDI76386.1 - 3.1e-142 474.0 5.2 3.1e-142 474.0 3.6 1.8 3 0 0 3 3 3 1 Protein phosphatase 2A regulatory B subunit (B56 family) Med15 PF09606.5 CDI76386.1 - 0.066 11.4 39.4 0.091 10.9 27.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Sec7_N PF12783.2 CDI76386.1 - 0.21 11.0 3.2 0.34 10.3 0.3 2.5 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DNA_pol_E_B PF04042.11 CDI76393.1 - 5.1e-30 104.3 0.1 9e-30 103.4 0.0 1.4 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Suf PF05843.9 CDI76393.1 - 1.2 8.8 10.7 1.6 8.3 7.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.8 CDI76393.1 - 6.9 6.4 21.3 9.8 5.9 14.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2508 PF10704.4 CDI76394.1 - 0.25 11.5 1.9 14 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Apt1 PF10351.4 CDI76394.1 - 2.7 6.7 5.0 1.5 7.5 0.6 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Inhibitor_I42 PF09394.5 CDI76398.1 - 0.0072 16.6 0.0 0.016 15.5 0.0 1.6 2 0 0 2 2 2 1 Chagasin family peptidase inhibitor I42 PmbA_TldD PF01523.11 CDI76398.1 - 0.0079 15.5 0.7 0.01 15.1 0.5 1.1 1 0 0 1 1 1 1 Putative modulator of DNA gyrase FAM176 PF14851.1 CDI76398.1 - 0.064 12.9 0.1 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF936 PF06075.7 CDI76400.1 - 0.00071 18.6 17.5 0.00071 18.6 12.1 2.1 2 0 0 2 2 2 1 Plant protein of unknown function (DUF936) Mito_carr PF00153.22 CDI76401.1 - 3.7e-09 36.1 3.2 3.1e-06 26.7 0.5 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein ArsB PF02040.10 CDI76401.1 - 0.061 12.2 0.2 0.072 12.0 0.1 1.1 1 0 0 1 1 1 0 Arsenical pump membrane protein BAF1_ABF1 PF04684.8 CDI76403.1 - 0.007 15.2 32.8 0.007 15.2 22.7 1.6 2 0 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor Herpes_UL95 PF03038.9 CDI76403.1 - 1.3 7.7 6.7 0.06 12.2 0.9 1.4 2 0 0 2 2 2 0 UL95 family Abhydrolase_5 PF12695.2 CDI76404.1 - 1.7e-27 95.9 0.0 4.2e-27 94.6 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI76404.1 - 1.4e-21 77.4 0.4 1.4e-20 74.1 0.3 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI76404.1 - 2.1e-13 50.3 0.2 3e-07 30.2 0.0 3.1 1 1 2 3 3 3 2 alpha/beta hydrolase fold AXE1 PF05448.7 CDI76404.1 - 9.9e-08 30.8 0.0 0.0048 15.4 0.0 2.2 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 CDI76404.1 - 8.5e-06 25.1 0.0 1.6e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.13 CDI76404.1 - 3.7e-05 23.1 0.0 0.00018 20.8 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 CDI76404.1 - 0.00045 19.8 0.0 0.00078 19.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CDI76404.1 - 0.00077 18.9 0.0 0.026 13.9 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 CDI76404.1 - 0.00095 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Lipase_3 PF01764.20 CDI76404.1 - 0.017 14.7 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) FSH1 PF03959.8 CDI76404.1 - 0.031 13.7 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Thioesterase PF00975.15 CDI76404.1 - 0.041 14.1 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 CDI76404.1 - 0.048 13.2 0.0 0.28 10.7 0.0 2.0 1 1 1 2 2 2 0 PGAP1-like protein DUF46 PF01864.12 CDI76404.1 - 0.049 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative integral membrane protein DUF46 DUF2305 PF10230.4 CDI76404.1 - 0.1 11.9 0.0 0.88 8.9 0.0 2.1 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Abhydrolase_4 PF08386.5 CDI76404.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein DUF818 PF05677.7 CDI76404.1 - 0.2 10.3 0.0 0.28 9.8 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) TAFII55_N PF04658.8 CDI76405.1 - 8.9e-15 54.5 0.0 1.2e-13 50.9 0.0 2.9 2 1 0 2 2 2 1 TAFII55 protein conserved region ELH PF02323.10 CDI76405.1 - 0.21 10.6 0.0 0.21 10.6 0.0 3.2 3 0 0 3 3 3 0 Egg-laying hormone precursor Ras PF00071.17 CDI76407.1 - 0.0012 18.2 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Abhydrolase_5 PF12695.2 CDI76408.1 - 4e-21 75.2 0.0 6.6e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI76408.1 - 1e-15 58.2 0.0 4.3e-14 52.9 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI76408.1 - 4.9e-10 39.3 0.0 8.7e-06 25.4 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.7 CDI76408.1 - 3.5e-07 29.0 0.0 0.0029 16.1 0.0 3.0 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 CDI76408.1 - 1.4e-05 24.4 0.0 4.6e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 CDI76408.1 - 7.6e-05 22.3 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.13 CDI76408.1 - 0.00013 21.5 0.0 0.00048 19.6 0.0 1.7 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.11 CDI76408.1 - 0.0005 19.5 0.0 0.0045 16.4 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DUF2305 PF10230.4 CDI76408.1 - 0.0012 18.3 0.0 0.15 11.4 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2305) FSH1 PF03959.8 CDI76408.1 - 0.0014 18.1 0.0 0.0041 16.5 0.0 1.8 2 0 0 2 2 2 1 Serine hydrolase (FSH1) DLH PF01738.13 CDI76408.1 - 0.0022 17.2 0.0 0.017 14.4 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF818 PF05677.7 CDI76408.1 - 0.018 13.8 0.0 0.023 13.4 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.6 CDI76408.1 - 0.026 14.2 0.0 0.15 11.7 0.0 2.0 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal LRR_6 PF13516.1 CDI76409.1 - 6.2e-06 25.7 6.1 1.1 9.5 0.1 7.4 8 0 0 8 8 8 3 Leucine Rich repeat Beta-lactamase PF00144.19 CDI76411.1 - 0.0061 15.6 0.2 0.011 14.7 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase Dodecin PF07311.7 CDI76413.1 - 0.12 12.4 1.9 18 5.4 0.0 2.9 2 0 0 2 2 2 0 Dodecin Med15 PF09606.5 CDI76413.1 - 5.4 5.0 34.2 8 4.5 23.7 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF572 PF04502.8 CDI76416.1 - 2 7.5 18.7 4.4 6.4 13.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) ubiquitin PF00240.18 CDI76418.1 - 5.7e-15 54.4 0.1 7.5e-15 54.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CDI76418.1 - 6.1e-08 32.2 0.0 7.8e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDI76418.1 - 0.0018 18.5 0.2 0.0047 17.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain HTH_15 PF12324.3 CDI76418.1 - 0.0032 17.0 0.3 0.0051 16.4 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of alkylmercury lyase DUF2407 PF10302.4 CDI76418.1 - 0.0033 17.5 0.0 0.0043 17.2 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain CLP_protease PF00574.18 CDI76418.1 - 0.026 14.1 0.2 0.032 13.9 0.1 1.1 1 0 0 1 1 1 0 Clp protease Rad60-SLD_2 PF13881.1 CDI76418.1 - 0.15 11.9 0.0 0.53 10.1 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SseC PF04888.7 CDI76419.1 - 0.0044 16.4 20.5 0.0044 16.4 14.2 13.4 2 2 8 11 11 11 1 Secretion system effector C (SseC) like family TB2_DP1_HVA22 PF03134.14 CDI76420.1 - 7.2e-17 60.9 0.3 8.1e-16 57.5 0.2 2.1 1 1 1 2 2 2 1 TB2/DP1, HVA22 family DEAD PF00270.24 CDI76421.1 - 3.1e-37 127.6 0.1 3.1e-37 127.6 0.0 2.5 3 0 0 3 3 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI76421.1 - 5.9e-27 93.3 0.4 5.9e-27 93.3 0.2 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain tRNA-synt_1b PF00579.20 CDI76421.1 - 0.0017 17.5 0.1 0.0048 16.0 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) AAA_19 PF13245.1 CDI76421.1 - 0.0025 17.5 0.1 0.011 15.4 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 CDI76421.1 - 0.027 14.6 0.1 0.22 11.6 0.0 2.5 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.1 CDI76421.1 - 0.066 12.2 0.0 0.066 12.2 0.0 2.9 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit AIF_C PF14721.1 CDI76421.1 - 0.98 9.6 8.3 1.8 8.8 5.7 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tom22 PF04281.8 CDI76421.1 - 1.4 8.4 8.2 3.2 7.3 4.5 2.2 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 Pex14_N PF04695.8 CDI76421.1 - 4 7.5 12.8 7.3 6.6 8.9 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.9 CDI76421.1 - 4.1 7.0 14.6 7.9 6.1 10.1 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FimP PF09766.4 CDI76421.1 - 9.4 5.1 22.6 16 4.4 15.6 1.4 1 0 0 1 1 1 0 Fms-interacting protein Med15 PF09606.5 CDI76422.1 - 0.00021 19.6 38.3 0.00021 19.6 26.5 19.0 11 5 3 17 17 17 4 ARC105 or Med15 subunit of Mediator complex non-fungal DEAD PF00270.24 CDI76424.1 - 7.5e-11 41.8 2.1 9.6e-07 28.4 0.8 3.5 2 1 0 2 2 2 2 DEAD/DEAH box helicase DUF605 PF04652.11 CDI76424.1 - 0.79 9.0 25.9 1.1 8.5 6.7 2.1 2 0 0 2 2 2 0 Vta1 like SOBP PF15279.1 CDI76424.1 - 6 7.1 12.6 2.5 8.4 4.5 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein DUF1428 PF07237.6 CDI76425.1 - 0.043 13.7 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) DUF4045 PF13254.1 CDI76427.1 - 0.021 14.1 28.4 0.023 13.9 19.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) U79_P34 PF03064.11 CDI76427.1 - 0.12 11.9 25.4 0.13 11.7 17.6 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF1510 PF07423.6 CDI76427.1 - 0.14 11.5 43.5 0.17 11.2 30.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) BSP_II PF05432.6 CDI76427.1 - 0.43 9.8 20.0 0.55 9.4 13.8 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Raftlin PF15250.1 CDI76427.1 - 0.52 8.7 25.9 0.64 8.4 17.9 1.2 1 0 0 1 1 1 0 Raftlin Nha1_C PF08619.5 CDI76427.1 - 1.6 7.8 34.3 1.9 7.7 23.8 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus SDA1 PF05285.7 CDI76427.1 - 2.6 7.2 36.4 3.4 6.8 25.3 1.1 1 0 0 1 1 1 0 SDA1 Hid1 PF12722.2 CDI76427.1 - 3 5.4 35.3 3.4 5.2 24.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAGA-Tad1 PF12767.2 CDI76427.1 - 4 7.0 31.6 5.2 6.6 21.9 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit SID-1_RNA_chan PF13965.1 CDI76427.1 - 4.3 5.3 18.7 5.5 5.0 13.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2852 PF11014.3 CDI76427.1 - 5.6 6.9 16.2 9.6 6.1 11.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2852) Utp14 PF04615.8 CDI76427.1 - 6.8 4.7 45.8 8.1 4.4 31.8 1.0 1 0 0 1 1 1 0 Utp14 protein Radial_spoke PF04712.7 CDI76428.1 - 7.6e-85 285.5 0.0 1.7e-79 267.8 0.0 3.1 2 1 1 3 3 3 2 Radial spokehead-like protein Neurochondrin PF05536.6 CDI76429.1 - 0.019 13.2 0.0 0.042 12.1 0.0 1.4 1 0 0 1 1 1 0 Neurochondrin Phage_H_T_join PF05521.6 CDI76429.1 - 0.69 10.2 3.5 0.66 10.3 0.1 2.9 2 0 0 2 2 2 0 Phage head-tail joining protein GCC2_GCC3 PF07699.8 CDI76429.1 - 0.72 9.4 5.7 15 5.2 4.0 2.6 1 1 0 1 1 1 0 GCC2 and GCC3 Nol1_Nop2_Fmu PF01189.12 CDI76430.1 - 1.9e-08 34.0 12.9 1.1e-05 24.9 0.1 3.3 3 0 0 3 3 3 2 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 CDI76430.1 - 7.7e-06 25.9 4.5 3e-05 24.0 0.6 3.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI76430.1 - 0.0012 19.2 1.1 0.86 10.1 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain AAA_23 PF13476.1 CDI76430.1 - 0.0029 17.9 10.2 0.0052 17.1 6.2 2.0 2 0 0 2 2 2 1 AAA domain Methyltransf_31 PF13847.1 CDI76430.1 - 0.0048 16.4 3.7 0.28 10.7 0.1 3.6 2 2 1 3 3 3 1 Methyltransferase domain Methyltrans_SAM PF10672.4 CDI76430.1 - 0.0097 14.7 0.2 0.16 10.7 0.1 2.3 2 0 0 2 2 2 1 S-adenosylmethionine-dependent methyltransferase Methyltransf_12 PF08242.7 CDI76430.1 - 0.016 15.7 1.2 1.4 9.4 0.3 2.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 CDI76430.1 - 0.06 13.7 0.1 0.06 13.7 0.1 2.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 CDI76430.1 - 0.18 12.4 13.1 3.3 8.3 1.7 3.9 3 2 0 3 3 3 0 Methyltransferase domain Serinc PF03348.10 CDI76431.1 - 1.6 7.3 5.6 21 3.6 0.0 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) Band_3_cyto PF07565.8 CDI76431.1 - 3.6 7.0 12.7 18 4.7 0.1 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Ctr PF04145.10 CDI76431.1 - 9 6.3 8.3 97 2.9 4.5 2.7 2 0 0 2 2 2 0 Ctr copper transporter family UQ_con PF00179.21 CDI76434.1 - 8.6e-37 125.6 0.0 9.9e-37 125.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDI76434.1 - 0.0021 17.9 0.0 0.0029 17.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 CDI76434.1 - 0.028 14.1 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B BAF1_ABF1 PF04684.8 CDI76436.1 - 0.017 14.0 21.2 0.035 12.9 14.7 1.6 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4208 PF13907.1 CDI76436.1 - 0.038 14.1 5.3 0.15 12.2 3.7 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Dus PF01207.12 CDI76437.1 - 7e-47 159.7 0.0 4.9e-29 101.1 0.0 2.1 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 CDI76437.1 - 3.5e-05 22.9 0.0 0.0015 17.5 0.0 2.1 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.16 CDI76437.1 - 0.00024 20.4 0.0 0.00045 19.5 0.0 1.5 1 0 0 1 1 1 1 Histidine biosynthesis protein IMPDH PF00478.20 CDI76437.1 - 0.0046 15.8 0.1 0.0081 15.0 0.0 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 CDI76437.1 - 0.005 16.0 0.4 0.011 14.8 0.1 1.6 1 1 0 1 1 1 1 Nitronate monooxygenase G3P_antiterm PF04309.7 CDI76437.1 - 0.0083 15.1 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Glycerol-3-phosphate responsive antiterminator SR-25 PF10500.4 CDI76437.1 - 0.43 10.0 8.9 0.73 9.2 6.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.20 CDI76439.1 - 2.7e-28 98.8 0.0 8.5e-18 64.4 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76439.1 - 6.8e-16 58.1 0.0 1.9e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase CAF-1_p150 PF11600.3 CDI76440.1 - 0.08 12.3 15.8 0.011 15.0 7.1 2.3 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PmbA_TldD PF01523.11 CDI76440.1 - 1.4 8.1 11.3 0.65 9.2 0.3 3.0 3 0 0 3 3 3 0 Putative modulator of DNA gyrase DUF1635 PF07795.6 CDI76440.1 - 4.7 6.5 14.4 0.052 12.9 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Plasmodium_Vir PF05795.6 CDI76440.1 - 5.8 6.0 8.4 0.52 9.4 2.3 1.8 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Utp11 PF03998.8 CDI76441.1 - 7.1e-19 68.5 49.4 1.5e-15 57.6 34.2 3.1 1 1 0 1 1 1 1 Utp11 protein PPP4R2 PF09184.6 CDI76441.1 - 0.23 11.0 12.0 0.4 10.1 8.3 1.5 1 0 0 1 1 1 0 PPP4R2 tRNA_int_endo PF01974.12 CDI76442.1 - 1.6e-10 40.6 0.0 0.00012 21.7 0.0 2.3 2 0 0 2 2 2 2 tRNA intron endonuclease, catalytic C-terminal domain Histone_HNS PF00816.16 CDI76442.1 - 4 7.9 7.8 0.8 10.2 0.1 2.1 2 0 0 2 2 2 0 H-NS histone family adh_short PF00106.20 CDI76443.1 - 7.8e-14 51.9 2.9 6.9e-09 35.8 0.1 2.6 2 1 1 3 3 3 2 short chain dehydrogenase KR PF08659.5 CDI76443.1 - 7.3e-07 29.0 0.4 6.2e-06 25.9 0.0 2.1 1 1 1 2 2 2 1 KR domain NAD_binding_10 PF13460.1 CDI76443.1 - 3.3e-06 27.2 0.1 5.2e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CDI76443.1 - 0.00038 19.4 0.0 0.00049 19.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 CDI76443.1 - 0.0041 17.2 0.1 0.0072 16.4 0.1 1.4 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CDI76443.1 - 0.0098 16.3 0.3 0.022 15.1 0.2 1.7 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.16 CDI76443.1 - 0.065 12.6 0.0 0.41 10.0 0.0 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Ldh_1_N PF00056.18 CDI76443.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain zf-B_box PF00643.19 CDI76444.1 - 6.3e-10 38.7 9.4 4.6e-05 23.2 1.0 2.2 2 0 0 2 2 2 2 B-box zinc finger zf-UBP PF02148.14 CDI76444.1 - 6.9 6.8 9.0 12 6.1 1.4 2.4 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_M14 PF00246.19 CDI76446.1 - 6.2e-29 101.4 0.0 6.2e-29 101.4 0.0 4.1 3 1 0 4 4 4 1 Zinc carboxypeptidase Pex19 PF04614.7 CDI76448.1 - 0.13 11.8 0.9 0.38 10.3 0.1 2.0 2 0 0 2 2 2 0 Pex19 protein family Mic1 PF07035.7 CDI76450.1 - 0.003 16.9 0.5 0.066 12.5 0.0 2.5 2 0 0 2 2 2 2 Colon cancer-associated protein Mic1-like DASH_Dam1 PF08653.5 CDI76451.1 - 0.072 12.8 0.1 8.1 6.2 0.0 2.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF4546 PF15079.1 CDI76451.1 - 0.075 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4546) SWI-SNF_Ssr4 PF08549.5 CDI76451.1 - 0.29 9.3 7.1 0.32 9.2 4.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Herpes_BLLF1 PF05109.8 CDI76451.1 - 0.36 8.7 7.9 0.4 8.5 5.5 1.0 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) RAB3GAP2_N PF14655.1 CDI76452.1 - 7.8e-06 25.1 16.0 0.00015 20.9 1.6 2.9 3 0 0 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Med15 PF09606.5 CDI76452.1 - 2.3 6.3 60.8 0.056 11.6 10.7 3.2 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal AMPKBI PF04739.10 CDI76453.1 - 0.73 9.7 7.3 0.81 9.5 5.0 1.1 1 0 0 1 1 1 0 5'-AMP-activated protein kinase beta subunit, interation domain LuxC PF05893.9 CDI76453.1 - 1.3 7.6 7.5 1.5 7.4 5.2 1.1 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF3597 PF12200.3 CDI76453.1 - 3.5 8.0 6.1 3.7 7.9 4.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DNA_pack_N PF02500.10 CDI76453.1 - 3.6 7.0 10.4 3.7 6.9 7.2 1.0 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus HD-ZIP_N PF04618.7 CDI76453.1 - 5.1 7.6 10.0 6.1 7.4 6.9 1.1 1 0 0 1 1 1 0 HD-ZIP protein N terminus DUF4496 PF14908.1 CDI76453.1 - 8.1 6.3 10.7 8.5 6.2 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4496) Hid1 PF12722.2 CDI76453.1 - 9.4 3.7 14.6 9.5 3.7 10.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TctA PF01970.11 CDI76454.1 - 0.22 9.9 0.4 0.4 9.0 0.3 1.3 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family LON PF02190.11 CDI76455.1 - 2.3e-16 60.0 0.6 1.9e-14 53.8 0.4 2.7 1 1 0 1 1 1 1 ATP-dependent protease La (LON) domain Spore_coat_CotO PF14153.1 CDI76455.1 - 0.0013 18.2 18.7 0.0013 18.2 13.0 2.8 2 0 0 2 2 2 1 Spore coat protein CotO Med15 PF09606.5 CDI76455.1 - 0.022 12.9 80.2 0.082 11.0 36.1 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SAPS PF04499.10 CDI76455.1 - 0.045 12.4 13.7 0.13 10.8 8.0 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein GAGA_bind PF06217.7 CDI76455.1 - 0.42 10.5 26.2 2 8.2 12.2 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family Ycf1 PF05758.7 CDI76455.1 - 1.4 6.5 18.1 0.03 12.0 7.9 1.6 2 0 0 2 2 2 0 Ycf1 PAT1 PF09770.4 CDI76455.1 - 2.4 6.2 67.4 0.6 8.2 30.1 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Mem_trans PF03547.13 CDI76455.1 - 2.5 6.3 5.4 5 5.3 3.8 1.6 1 0 0 1 1 1 0 Membrane transport protein NAC PF01849.13 CDI76456.1 - 6.6e-20 70.3 0.6 1.1e-19 69.7 0.4 1.3 1 0 0 1 1 1 1 NAC domain UBA PF00627.26 CDI76456.1 - 0.003 17.3 0.0 0.0061 16.3 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Ribosomal_60s PF00428.14 CDI76456.1 - 4.1 7.8 18.4 0.11 12.8 6.7 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4349 PF14257.1 CDI76456.1 - 8.9 5.4 13.4 4.6 6.3 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) PGK PF00162.14 CDI76457.1 - 1.3e-147 491.3 1.8 1.5e-147 491.2 1.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Mitofilin PF09731.4 CDI76458.1 - 0.00044 19.0 26.1 0.00059 18.6 18.1 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Macoilin PF09726.4 CDI76458.1 - 0.00069 18.0 45.6 0.0011 17.3 31.6 1.3 1 0 0 1 1 1 1 Transmembrane protein Tim54 PF11711.3 CDI76458.1 - 0.75 8.3 8.3 0.31 9.5 4.2 1.6 1 1 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 zf-CCCH PF00642.19 CDI76459.1 - 0.0014 18.2 7.2 0.077 12.7 1.0 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PA26 PF04636.8 CDI76459.1 - 0.0033 16.1 3.8 0.0033 16.1 2.6 3.1 3 1 0 3 3 3 1 PA26 p53-induced protein (sestrin) TSA PF03249.8 CDI76464.1 - 0.13 10.7 11.0 0.17 10.3 7.6 1.1 1 0 0 1 1 1 0 Type specific antigen NAD_binding_4 PF07993.7 CDI76465.1 - 2.2e-50 170.9 0.0 1.8e-49 167.9 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 CDI76465.1 - 3.6e-08 33.1 0.0 8.7e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CDI76465.1 - 2.7e-07 29.6 2.1 5.4e-07 28.5 0.1 2.3 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 CDI76465.1 - 3.1 6.6 9.3 0.37 9.6 0.6 2.9 2 2 0 2 2 2 0 Polysaccharide biosynthesis protein SLA_LP_auto_ag PF05889.8 CDI76467.1 - 5.9e-66 222.5 0.0 3.5e-61 206.8 0.0 2.7 1 1 1 2 2 2 2 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Med15 PF09606.5 CDI76468.1 - 0.0033 15.7 26.1 0.0033 15.7 18.1 1.9 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Sporozoite_P67 PF05642.6 CDI76468.1 - 0.0051 14.7 4.5 0.047 11.5 0.1 2.1 2 0 0 2 2 2 2 Sporozoite P67 surface antigen Ribosomal_60s PF00428.14 CDI76468.1 - 0.031 14.6 12.1 0.031 14.6 8.4 3.2 2 1 0 2 2 2 0 60s Acidic ribosomal protein RskA PF10099.4 CDI76468.1 - 0.28 10.8 34.1 0.033 13.9 6.5 2.9 2 1 1 3 3 3 0 Anti-sigma-K factor rskA TFIIA PF03153.8 CDI76468.1 - 2.3 7.9 28.2 3 7.6 15.7 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.9 CDI76468.1 - 4.1 7.0 14.6 6.5 6.3 10.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2368 PF10166.4 CDI76468.1 - 4.6 6.8 11.9 10 5.7 8.3 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) PAT1 PF09770.4 CDI76468.1 - 7.4 4.6 27.5 10 4.2 19.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.14 CDI76469.1 - 1.3 9.4 9.8 27 5.2 4.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.8 CDI76469.1 - 8.6 6.1 30.6 2.1 8.1 18.1 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Filamin PF00630.14 CDI76470.1 - 2.9e-18 66.3 0.0 1.4e-17 64.1 0.0 2.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat CSD PF00313.17 CDI76471.1 - 0.00024 20.8 0.1 0.00081 19.1 0.0 1.9 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 CDI76471.1 - 0.1 12.0 0.2 0.25 10.8 0.1 1.7 1 1 0 1 1 1 0 Ribonuclease B OB domain MMS1_N PF10433.4 CDI76473.1 - 2.3e-78 263.5 0.0 1.9e-77 260.5 0.0 1.9 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 CDI76473.1 - 1e-07 31.3 0.0 5.9e-07 28.8 0.0 2.2 2 1 0 2 2 2 1 CPSF A subunit region Bac_luciferase PF00296.15 CDI76475.1 - 0.0051 15.9 5.4 0.041 13.0 0.1 2.2 2 0 0 2 2 2 2 Luciferase-like monooxygenase Ribosomal_60s PF00428.14 CDI76475.1 - 0.02 15.3 27.9 0.044 14.1 9.3 2.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein Adaptin_binding PF10199.4 CDI76475.1 - 0.11 12.7 0.4 0.17 12.2 0.3 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Adeno_PIX PF03955.9 CDI76475.1 - 0.86 10.1 6.1 1.1 9.8 1.6 2.1 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Shadoo PF14999.1 CDI76475.1 - 1.1 9.1 26.8 0.28 11.0 7.8 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF3457 PF11939.3 CDI76475.1 - 5.4 6.5 9.4 0.68 9.4 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3457) DUF3617 PF12276.3 CDI76475.1 - 7.8 5.9 10.8 0.57 9.6 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3617) Cyclin_N PF00134.18 CDI76477.1 - 0.0042 16.6 1.1 0.0042 16.6 0.8 5.2 6 0 0 6 6 6 1 Cyclin, N-terminal domain Tudor-knot PF11717.3 CDI76478.1 - 0.19 11.4 1.9 0.68 9.6 1.3 2.0 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain PAT1 PF09770.4 CDI76478.1 - 0.3 9.2 90.2 0.38 8.9 62.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2201_N PF13203.1 CDI76479.1 - 0.69 9.0 6.3 0.84 8.7 4.4 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain CDC45 PF02724.9 CDI76479.1 - 1.7 6.5 9.9 1.9 6.4 6.8 1.0 1 0 0 1 1 1 0 CDC45-like protein MSP1_C PF07462.6 CDI76479.1 - 4.3 5.6 6.7 4.9 5.4 4.6 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Sec3_C PF09763.4 CDI76479.1 - 6.8 4.6 17.7 7 4.6 12.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF572 PF04502.8 CDI76479.1 - 6.9 5.7 12.4 8.3 5.5 8.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Paf1 PF03985.8 CDI76479.1 - 8.5 4.9 8.3 8.6 4.9 5.8 1.0 1 0 0 1 1 1 0 Paf1 Apt1 PF10351.4 CDI76479.1 - 8.7 5.0 25.8 8.8 5.0 17.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AAR2 PF05282.6 CDI76481.1 - 9.5e-08 31.3 3.6 4.9e-05 22.4 1.5 3.7 2 2 1 4 4 4 2 AAR2 protein Vfa1 PF08432.5 CDI76481.1 - 0.0044 17.0 3.5 0.0044 17.0 2.4 3.2 3 0 0 3 3 3 1 AAA-ATPase Vps4-associated protein 1 GUCT PF08152.7 CDI76481.1 - 0.018 15.0 0.2 0.05 13.5 0.1 1.7 1 0 0 1 1 1 0 GUCT (NUC152) domain SOBP PF15279.1 CDI76481.1 - 2.4 8.4 27.8 1.6 9.0 14.4 2.4 2 0 0 2 2 2 0 Sine oculis-binding protein IncA PF04156.9 CDI76481.1 - 3.6 7.1 34.5 5.8 6.4 11.9 2.5 2 0 0 2 2 2 0 IncA protein RRM_1 PF00076.17 CDI76482.1 - 1.8e-17 62.7 0.1 3.1e-17 61.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76482.1 - 2.4e-12 46.6 0.1 5.5e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76482.1 - 0.00052 19.8 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP_SPB PF02978.14 CDI76482.1 - 0.023 14.9 1.6 0.07 13.3 1.1 1.8 1 0 0 1 1 1 0 Signal peptide binding domain TFIIA PF03153.8 CDI76482.1 - 0.37 10.6 8.1 0.56 10.0 5.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1212 PF06738.7 CDI76483.1 - 2.1 7.7 13.9 0.12 11.8 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1212) SpoU_methylase PF00588.14 CDI76484.1 - 6e-09 35.9 0.0 1.1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF1042 PF06294.6 CDI76486.1 - 1.4e-07 31.2 15.2 4.8e-05 23.0 0.0 4.3 4 0 0 4 4 4 2 Domain of Unknown Function (DUF1042) SprA-related PF12118.3 CDI76487.1 - 1e-06 28.3 35.7 1e-06 28.3 24.8 2.2 2 0 0 2 2 2 1 SprA-related family Sulfotransfer_1 PF00685.22 CDI76487.1 - 0.0003 20.1 4.3 0.0003 20.1 3.0 1.9 2 0 0 2 2 2 1 Sulfotransferase domain Pex14_N PF04695.8 CDI76487.1 - 0.0046 17.0 11.4 0.0046 17.0 7.9 4.1 3 1 1 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Cwf_Cwc_15 PF04889.7 CDI76487.1 - 0.09 12.4 38.6 0.098 12.3 14.0 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2126 PF09899.4 CDI76487.1 - 1.7 6.5 15.7 0.61 8.0 3.3 2.2 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF572 PF04502.8 CDI76487.1 - 4.2 6.4 41.7 1.1 8.4 17.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) TGF_beta PF00019.15 CDI76487.1 - 7.4 6.9 13.3 0.41 10.9 1.0 3.0 2 1 1 3 3 3 0 Transforming growth factor beta like domain Radical_SAM_N PF08497.5 CDI76487.1 - 7.9 5.3 13.2 6.9 5.4 0.8 2.1 2 0 0 2 2 2 0 Radical SAM N-terminal DnaJ PF00226.26 CDI76489.1 - 4.5e-12 45.5 0.0 5.3e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 DnaJ domain AAA_2 PF07724.9 CDI76490.1 - 0.028 14.3 0.1 0.058 13.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RskA PF10099.4 CDI76490.1 - 0.029 14.0 10.8 0.058 13.1 3.4 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF3824 PF12868.2 CDI76490.1 - 0.048 14.5 3.6 0.048 14.5 2.5 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) GN3L_Grn1 PF08701.6 CDI76490.1 - 0.44 10.4 17.6 0.25 11.2 1.9 3.2 2 1 1 3 3 3 0 GNL3L/Grn1 putative GTPase Ribosomal_60s PF00428.14 CDI76490.1 - 3.1 8.2 14.4 0.67 10.3 7.2 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4175 PF13779.1 CDI76493.1 - 0.00045 18.0 22.1 0.00045 18.0 15.3 6.2 5 2 1 6 6 6 1 Domain of unknown function (DUF4175) Ycf1 PF05758.7 CDI76493.1 - 0.0025 15.6 1.2 0.0025 15.6 0.8 2.6 3 0 0 3 3 3 2 Ycf1 SPX PF03105.14 CDI76493.1 - 6.7 6.4 36.6 0.18 11.5 2.4 3.6 3 0 0 3 3 3 0 SPX domain Cpn60_TCP1 PF00118.19 CDI76495.1 - 5.3e-40 137.4 0.1 6.6e-40 137.1 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PPTA PF01239.17 CDI76496.1 - 1.9e-18 64.9 10.5 2.2e-10 39.4 2.4 3.4 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat OmpH PF03938.9 CDI76496.1 - 0.0044 16.9 16.5 0.0044 16.9 11.4 1.6 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) AAA_23 PF13476.1 CDI76496.1 - 0.006 16.9 3.3 0.0069 16.7 2.3 1.2 1 0 0 1 1 1 1 AAA domain DUF1247 PF06851.6 CDI76496.1 - 0.0064 16.1 0.6 0.015 14.9 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1247) Spt20 PF12090.3 CDI76496.1 - 0.0095 15.3 1.8 0.015 14.6 1.2 1.3 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.8 CDI76496.1 - 0.014 15.4 4.8 0.025 14.6 1.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FHIPEP PF00771.15 CDI76496.1 - 0.016 13.5 1.7 0.019 13.3 1.2 1.1 1 0 0 1 1 1 0 FHIPEP family PEX11 PF05648.9 CDI76496.1 - 0.018 14.2 0.8 0.031 13.5 0.6 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Spore_YhcN_YlaJ PF09580.5 CDI76496.1 - 0.034 14.2 3.0 0.052 13.6 2.1 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FimP PF09766.4 CDI76496.1 - 0.038 13.0 8.9 0.057 12.4 6.2 1.2 1 0 0 1 1 1 0 Fms-interacting protein FAM176 PF14851.1 CDI76496.1 - 0.039 13.6 0.8 0.079 12.6 0.5 1.5 1 0 0 1 1 1 0 FAM176 family SR-25 PF10500.4 CDI76496.1 - 0.04 13.4 15.1 0.21 11.0 3.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ctr PF04145.10 CDI76496.1 - 0.046 13.7 0.8 0.046 13.7 0.6 1.9 3 0 0 3 3 2 0 Ctr copper transporter family OSTbeta PF15048.1 CDI76496.1 - 0.046 13.7 3.1 0.067 13.2 1.3 1.8 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein GD_AH_C PF04295.8 CDI76496.1 - 0.051 12.2 0.9 0.067 11.8 0.6 1.1 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus PSK PF06404.7 CDI76496.1 - 0.061 14.1 3.1 0.12 13.1 1.3 2.2 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) SKIP_SNW PF02731.10 CDI76496.1 - 0.072 12.5 8.7 0.12 11.8 6.0 1.3 1 0 0 1 1 1 0 SKIP/SNW domain MDMPI_N PF11716.3 CDI76496.1 - 0.12 12.7 6.9 0.23 11.8 4.8 1.4 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Med15 PF09606.5 CDI76496.1 - 0.2 9.8 15.9 0.02 13.1 8.2 1.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Gly-zipper_OmpA PF13436.1 CDI76496.1 - 0.2 11.2 9.5 0.12 11.9 5.1 1.7 2 0 0 2 2 1 0 Glycine-zipper containing OmpA-like membrane domain DUF3373 PF11853.3 CDI76496.1 - 0.33 9.4 3.7 0.44 9.0 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Suf PF05843.9 CDI76496.1 - 0.58 9.8 13.7 0.77 9.4 9.5 1.4 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) PHD_3 PF13922.1 CDI76496.1 - 1.7 8.9 6.8 5 7.4 4.7 1.8 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Cnd1_N PF12922.2 CDI76496.1 - 2.5 7.7 10.4 0.22 11.1 4.1 1.5 2 0 0 2 2 1 0 non-SMC mitotic condensation complex subunit 1, N-term Conotoxin PF02950.12 CDI76496.1 - 2.9 8.7 4.7 3.3 8.5 1.5 2.3 2 0 0 2 2 2 0 Conotoxin OAD_gamma PF04277.8 CDI76496.1 - 4.3 7.7 9.0 1.4 9.3 2.4 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF775 PF05603.7 CDI76496.1 - 6.5 6.2 9.6 0.64 9.4 3.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Pkinase PF00069.20 CDI76498.1 - 2.5e-69 233.3 0.0 2.4e-46 158.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76498.1 - 7.6e-34 116.9 0.0 8.7e-28 97.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_1 PF00036.27 CDI76498.1 - 6.7e-30 100.0 3.4 2.9e-07 29.2 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDI76498.1 - 3e-25 88.1 0.0 2.7e-11 43.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI76498.1 - 1.7e-22 77.2 0.2 1.8e-06 27.3 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 CDI76498.1 - 7.1e-22 75.7 3.0 1.6e-06 27.1 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 CDI76498.1 - 3.5e-19 68.1 8.0 2.8e-06 26.8 0.4 4.9 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_4 PF12763.2 CDI76498.1 - 5.3e-06 26.1 0.4 0.021 14.5 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Kdo PF06293.9 CDI76498.1 - 0.00019 20.5 0.0 0.00042 19.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.4 CDI76498.1 - 0.00055 19.9 0.0 0.09 12.8 0.0 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region APH PF01636.18 CDI76498.1 - 0.00057 19.6 0.0 0.042 13.5 0.0 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 CDI76498.1 - 0.0024 16.9 0.0 0.16 10.8 0.0 2.4 2 0 0 2 2 2 1 Kinase-like EF-hand_9 PF14658.1 CDI76498.1 - 0.0048 16.7 0.0 0.078 12.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain DUF1840 PF08895.6 CDI76499.1 - 0.29 11.1 7.3 0.37 10.8 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Cwf_Cwc_15 PF04889.7 CDI76499.1 - 0.52 9.9 7.7 0.84 9.3 1.6 2.0 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ssl1 PF04056.9 CDI76499.1 - 0.54 9.8 3.2 0.61 9.6 2.2 1.0 1 0 0 1 1 1 0 Ssl1-like DUF972 PF06156.8 CDI76499.1 - 0.62 10.4 3.9 0.75 10.1 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF4557 PF15101.1 CDI76499.1 - 1.4 8.7 8.6 1.5 8.6 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) BRF1 PF07741.8 CDI76499.1 - 1.4 9.1 4.5 1.7 8.9 3.1 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF3186 PF11382.3 CDI76499.1 - 1.5 7.9 8.6 1.6 7.7 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) Suf PF05843.9 CDI76500.1 - 0.68 9.6 6.5 0.61 9.7 1.5 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SOUL PF04832.7 CDI76501.1 - 2.4e-27 95.5 2.3 8.8e-20 70.9 0.0 2.8 3 0 0 3 3 3 2 SOUL heme-binding protein SSP160 PF06933.6 CDI76501.1 - 6.1e-05 21.2 9.8 6.8e-05 21.0 6.8 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 ORC6 PF05460.8 CDI76501.1 - 0.0001 21.5 0.3 0.00013 21.1 0.2 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Sporozoite_P67 PF05642.6 CDI76501.1 - 0.044 11.6 6.8 0.052 11.4 4.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Macoilin PF09726.4 CDI76501.1 - 0.19 10.0 5.5 0.22 9.7 3.8 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF515 PF04415.7 CDI76501.1 - 1.3 7.2 9.3 1.7 6.7 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Herpes_capsid PF06112.6 CDI76501.1 - 1.9 8.5 14.0 2.9 7.9 9.7 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein RRM_1 PF00076.17 CDI76502.1 - 7.4e-07 28.7 0.0 1.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76502.1 - 1.1e-05 25.2 0.0 2.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Sporozoite_P67 PF05642.6 CDI76502.1 - 0.0012 16.8 1.2 0.0013 16.6 0.8 1.2 1 0 0 1 1 1 1 Sporozoite P67 surface antigen MACPF PF01823.14 CDI76502.1 - 0.0046 16.6 1.0 0.0098 15.6 0.7 1.5 1 0 0 1 1 1 1 MAC/Perforin domain SprA-related PF12118.3 CDI76502.1 - 0.83 8.9 57.6 0.065 12.5 14.9 2.1 2 0 0 2 2 2 0 SprA-related family Plasmodium_Vir PF05795.6 CDI76502.1 - 1.2 8.2 5.4 1.9 7.5 3.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Cwf_Cwc_15 PF04889.7 CDI76503.1 - 0.0076 15.9 5.2 0.0076 15.9 3.6 6.0 5 1 0 5 5 5 2 Cwf15/Cwc15 cell cycle control protein XPG_I PF00867.13 CDI76504.1 - 4.5e-25 87.5 0.2 5.1e-24 84.1 0.1 3.1 1 0 0 1 1 1 1 XPG I-region SPX PF03105.14 CDI76504.1 - 0.001 18.9 3.8 0.001 18.9 2.7 8.1 5 3 2 7 7 7 1 SPX domain Chloroa_b-bind PF00504.16 CDI76505.1 - 0.029 14.6 0.8 0.038 14.2 0.6 1.2 1 0 0 1 1 1 0 Chlorophyll A-B binding protein RskA PF10099.4 CDI76505.1 - 4.9 6.8 25.2 6.5 6.4 11.7 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA ETRAMP PF09716.5 CDI76505.1 - 5.6 6.9 9.0 11 6.0 2.9 2.7 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PAT1 PF09770.4 CDI76505.1 - 5.7 5.0 64.5 6.7 4.8 44.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sin_N PF04801.8 CDI76506.1 - 8.1e-40 136.9 41.3 2.2e-33 115.7 24.2 6.6 1 1 2 3 3 3 2 Sin-like protein conserved region DUF4367 PF14285.1 CDI76506.1 - 0.0014 18.0 2.7 0.038 13.3 0.1 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4367) TFIIA PF03153.8 CDI76508.1 - 0.03 14.2 1.1 0.038 13.8 0.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.14 CDI76508.1 - 2 8.8 28.4 15 6.0 15.9 2.7 2 1 0 2 2 2 0 60s Acidic ribosomal protein DUF2360 PF10152.4 CDI76508.1 - 7.1 6.9 7.0 19 5.5 3.6 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF972 PF06156.8 CDI76509.1 - 0.2 12.0 9.3 0.1 12.9 4.5 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DivIVA PF05103.8 CDI76509.1 - 0.5 10.4 10.9 0.27 11.2 5.2 1.9 2 0 0 2 2 2 0 DivIVA protein Pinin_SDK_memA PF04696.8 CDI76509.1 - 0.83 9.2 8.9 6.9 6.2 4.5 2.4 2 1 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Tho2 PF11262.3 CDI76509.1 - 2.1 7.3 6.2 5.2 6.0 4.0 1.8 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF4407 PF14362.1 CDI76509.1 - 3.9 6.3 8.6 8.8 5.1 5.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Pacifastin_I PF05375.8 CDI76511.1 - 0.11 12.0 3.2 0.25 10.8 2.2 1.6 1 0 0 1 1 1 0 Pacifastin inhibitor (LCMII) Sporozoite_P67 PF05642.6 CDI76511.1 - 0.35 8.6 3.0 0.49 8.2 2.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SR-25 PF10500.4 CDI76511.1 - 8.3 5.8 29.2 0.079 12.4 8.5 2.3 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2052 PF09747.4 CDI76512.1 - 0.013 15.4 8.2 0.026 14.4 5.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FimP PF09766.4 CDI76512.1 - 0.15 11.1 10.3 0.23 10.5 7.2 1.2 1 0 0 1 1 1 0 Fms-interacting protein TraG-D_C PF12696.2 CDI76512.1 - 0.19 11.5 8.8 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Ebola_NP PF05505.7 CDI76512.1 - 0.49 8.3 10.9 0.19 9.7 5.7 1.5 2 0 0 2 2 2 0 Ebola nucleoprotein Rifin_STEVOR PF02009.11 CDI76512.1 - 0.78 9.3 6.8 1.1 8.8 4.7 1.2 1 0 0 1 1 1 0 Rifin/stevor family TFIIA PF03153.8 CDI76512.1 - 1 9.1 29.3 1.6 8.5 20.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1510 PF07423.6 CDI76512.1 - 1.8 7.9 13.9 3 7.1 9.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FLO_LFY PF01698.11 CDI76512.1 - 4.7 5.9 9.1 6.9 5.4 6.3 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein AARP2CN PF08142.7 CDI76514.1 - 1.4e-07 30.9 7.5 6.9e-06 25.5 5.2 3.0 1 1 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 CDI76514.1 - 1.8e-05 24.2 0.5 1.8e-05 24.2 0.4 2.7 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 CDI76514.1 - 3.2e-05 24.7 0.0 9.4e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI76514.1 - 0.00013 22.0 0.0 0.00013 22.0 0.0 3.1 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.1 CDI76514.1 - 0.00041 20.5 0.0 0.0073 16.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CDI76514.1 - 0.00058 20.0 0.0 0.00058 20.0 0.0 2.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CDI76514.1 - 0.0025 17.5 1.2 0.016 14.9 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_25 PF13481.1 CDI76514.1 - 0.0049 16.3 0.3 0.036 13.4 0.0 2.6 2 1 1 3 3 3 1 AAA domain OmpH PF03938.9 CDI76514.1 - 0.0053 16.7 12.8 0.0053 16.7 8.9 5.1 5 0 0 5 5 4 1 Outer membrane protein (OmpH-like) MMR_HSR1 PF01926.18 CDI76514.1 - 0.0069 16.3 0.2 0.056 13.4 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 CDI76514.1 - 0.0095 16.0 0.7 0.033 14.3 0.0 2.3 2 0 0 2 2 2 1 RNA helicase KAP_NTPase PF07693.9 CDI76514.1 - 0.021 13.8 6.8 0.29 10.0 4.7 2.5 1 1 0 1 1 1 0 KAP family P-loop domain AAA_5 PF07728.9 CDI76514.1 - 0.035 13.8 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CDI76514.1 - 0.22 11.3 0.0 0.22 11.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.1 CDI76514.1 - 0.44 10.8 0.0 0.44 10.8 0.0 3.6 4 0 0 4 4 4 0 AAA domain Herpes_UL87 PF03043.9 CDI76515.1 - 0.014 13.8 6.2 0.021 13.2 4.3 1.4 1 0 0 1 1 1 0 Herpesvirus UL87 family Helicase_C PF00271.26 CDI76515.1 - 0.3 10.9 0.0 0.3 10.9 0.0 3.0 2 1 0 2 2 2 0 Helicase conserved C-terminal domain DUF572 PF04502.8 CDI76515.1 - 2.6 7.1 17.8 1.6 7.8 8.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) BTV_NS2 PF04514.7 CDI76515.1 - 3.2 6.5 9.2 6.8 5.4 6.4 1.5 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Med15 PF09606.5 CDI76515.1 - 3.9 5.5 45.9 5.3 5.1 31.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI76516.1 - 0.00081 18.2 0.6 0.00081 18.2 0.4 5.0 5 1 0 5 5 5 3 Transcriptional activator LAG-3 AP2 PF00847.15 CDI76518.1 - 8e-07 29.1 1.0 1.9e-06 27.8 0.7 1.7 1 0 0 1 1 1 1 AP2 domain Med15 PF09606.5 CDI76518.1 - 0.017 13.3 24.4 0.021 13.0 16.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SHR3_chaperone PF08229.6 CDI76518.1 - 0.12 11.3 3.2 0.16 10.8 2.2 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 DUF3138 PF11336.3 CDI76518.1 - 5.8 4.9 11.9 11 4.1 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Chromo PF00385.19 CDI76519.1 - 1.1e-09 37.8 0.0 2.9e-07 30.0 0.0 2.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Macoilin PF09726.4 CDI76520.1 - 3.8 5.6 15.8 5.6 5.1 11.0 1.2 1 0 0 1 1 1 0 Transmembrane protein Med15 PF09606.5 CDI76525.1 - 0.002 16.4 9.5 0.0027 16.0 6.6 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Ripply PF14998.1 CDI76525.1 - 0.031 14.3 1.0 0.076 13.1 0.7 1.6 1 0 0 1 1 1 0 Transcription Regulator WBP-1 PF11669.3 CDI76525.1 - 0.11 12.5 0.3 0.21 11.6 0.2 1.6 1 1 0 1 1 1 0 WW domain-binding protein 1 DivIC PF04977.10 CDI76525.1 - 0.22 11.0 7.0 0.54 9.7 4.9 1.7 1 0 0 1 1 1 0 Septum formation initiator Med3 PF11593.3 CDI76525.1 - 2.9 7.0 16.1 0.16 11.1 7.6 1.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal CAF-1_p150 PF11600.3 CDI76526.1 - 0.00097 18.5 25.7 0.0011 18.3 17.8 1.0 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Nop53 PF07767.6 CDI76526.1 - 0.016 14.1 32.2 0.019 13.9 22.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Raftlin PF15250.1 CDI76526.1 - 0.021 13.3 23.0 0.024 13.1 16.0 1.0 1 0 0 1 1 1 0 Raftlin DUF1510 PF07423.6 CDI76526.1 - 0.036 13.4 26.2 0.045 13.1 18.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 CDI76526.1 - 0.063 11.3 21.8 0.07 11.1 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein BTV_NS2 PF04514.7 CDI76526.1 - 0.1 11.4 19.6 0.11 11.3 13.6 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 PPP4R2 PF09184.6 CDI76526.1 - 0.15 11.5 22.2 0.19 11.2 15.4 1.0 1 0 0 1 1 1 0 PPP4R2 RR_TM4-6 PF06459.7 CDI76526.1 - 0.26 11.1 24.8 0.29 10.9 17.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.1 CDI76526.1 - 0.32 10.4 35.4 0.38 10.1 24.5 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Nucleoside_tran PF01733.13 CDI76526.1 - 0.38 9.8 6.4 0.49 9.5 4.5 1.1 1 0 0 1 1 1 0 Nucleoside transporter Pox_Ag35 PF03286.9 CDI76526.1 - 0.48 9.9 16.4 0.59 9.6 11.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM60A PF15396.1 CDI76526.1 - 0.54 9.9 21.7 0.63 9.7 15.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Myco_19_kDa PF05481.7 CDI76526.1 - 0.6 9.9 11.1 0.76 9.5 7.7 1.1 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen PAT1 PF09770.4 CDI76526.1 - 0.62 8.2 53.0 0.68 8.1 36.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DDHD PF02862.12 CDI76526.1 - 0.66 9.7 24.5 1 9.1 17.0 1.4 1 0 0 1 1 1 0 DDHD domain FLO_LFY PF01698.11 CDI76526.1 - 0.67 8.7 25.6 0.77 8.5 17.8 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF726 PF05277.7 CDI76526.1 - 0.7 8.7 4.1 0.76 8.6 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) UPF0564 PF10595.4 CDI76526.1 - 0.71 8.7 33.9 0.74 8.6 23.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 Hamartin PF04388.7 CDI76526.1 - 0.74 8.4 20.3 0.85 8.2 14.1 1.0 1 0 0 1 1 1 0 Hamartin protein CCDC71L PF15374.1 CDI76526.1 - 0.8 8.9 22.3 0.93 8.7 15.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SID-1_RNA_chan PF13965.1 CDI76526.1 - 0.92 7.5 14.9 1.1 7.2 10.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Med15 PF09606.5 CDI76526.1 - 0.97 7.5 70.6 1.1 7.3 48.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SprA-related PF12118.3 CDI76526.1 - 0.98 8.6 56.2 1.4 8.2 38.9 1.2 1 0 0 1 1 1 0 SprA-related family Caldesmon PF02029.10 CDI76526.1 - 1 7.7 23.1 1.1 7.5 16.0 1.1 1 0 0 1 1 1 0 Caldesmon DUF4045 PF13254.1 CDI76526.1 - 1 8.5 26.1 1.2 8.3 18.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Dicty_REP PF05086.7 CDI76526.1 - 1.1 6.9 25.8 1.4 6.5 17.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SAGA-Tad1 PF12767.2 CDI76526.1 - 1.1 8.8 25.0 1.3 8.6 17.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit SPX PF03105.14 CDI76526.1 - 1.3 8.7 20.4 1.4 8.5 14.1 1.1 1 0 0 1 1 1 0 SPX domain DUF2052 PF09747.4 CDI76526.1 - 1.6 8.6 28.7 2 8.3 19.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC27 PF09507.5 CDI76526.1 - 1.6 7.8 30.2 2 7.5 21.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Peptidase_S15 PF02129.13 CDI76526.1 - 1.7 8.0 21.4 2.1 7.7 14.9 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) AAA_11 PF13086.1 CDI76526.1 - 1.7 8.1 20.8 2.1 7.8 14.4 1.1 1 0 0 1 1 1 0 AAA domain SOBP PF15279.1 CDI76526.1 - 1.7 8.9 25.4 1.8 8.9 17.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein TFIIA PF03153.8 CDI76526.1 - 1.7 8.4 49.0 2 8.2 34.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2215 PF10225.4 CDI76526.1 - 1.7 7.9 14.0 2.2 7.6 9.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Alpha_GJ PF03229.8 CDI76526.1 - 1.9 8.8 18.3 2.4 8.4 12.7 1.1 1 0 0 1 1 1 0 Alphavirus glycoprotein J GBP_C PF02841.9 CDI76526.1 - 2 7.5 36.4 2.4 7.2 25.2 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Nha1_C PF08619.5 CDI76526.1 - 2.1 7.5 24.8 2.5 7.3 17.2 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Herpes_env PF01673.13 CDI76526.1 - 2.1 6.7 20.6 2.5 6.5 14.2 1.2 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein CobT PF06213.7 CDI76526.1 - 2.3 7.2 23.6 3 6.9 16.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF342 PF03961.8 CDI76526.1 - 2.4 6.4 16.8 2.8 6.2 11.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Pneumo_phosprot PF02478.11 CDI76526.1 - 2.5 7.5 13.2 2.8 7.4 9.1 1.1 1 0 0 1 1 1 0 Pneumovirus phosphoprotein RNA_pol_Rpb1_5 PF04998.12 CDI76526.1 - 2.6 7.2 17.1 3.3 6.9 11.9 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF3337 PF11816.3 CDI76526.1 - 3 7.1 17.6 3.5 6.9 12.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Ycf1 PF05758.7 CDI76526.1 - 3 5.4 24.8 3.4 5.2 17.2 1.0 1 0 0 1 1 1 0 Ycf1 DUF4220 PF13968.1 CDI76526.1 - 3.2 6.7 12.8 3.8 6.5 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Herpes_TAF50 PF03326.8 CDI76526.1 - 3.7 6.3 35.1 4.3 6.1 24.3 1.0 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Paramyxo_ncap PF00973.14 CDI76526.1 - 4.1 5.9 23.8 4.7 5.7 16.5 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Spc7_N PF15402.1 CDI76526.1 - 4.6 5.1 29.4 5.8 4.8 20.4 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 GPCR_chapero_1 PF11904.3 CDI76526.1 - 4.7 6.2 20.2 5.5 6.0 14.0 1.2 1 0 0 1 1 1 0 GPCR-chaperone PBP_sp32 PF07222.7 CDI76526.1 - 4.8 6.2 34.8 5.8 6.0 24.1 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF572 PF04502.8 CDI76526.1 - 4.9 6.2 26.4 5.6 6.0 18.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) OPT PF03169.10 CDI76526.1 - 5 5.4 10.8 6.5 5.0 7.5 1.3 1 1 0 1 1 1 0 OPT oligopeptide transporter protein Hid1 PF12722.2 CDI76526.1 - 5 4.6 26.6 5.5 4.5 18.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Asp-B-Hydro_N PF05279.6 CDI76526.1 - 5 6.8 22.8 5.7 6.7 15.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Parvo_coat PF00740.13 CDI76526.1 - 5.1 5.9 32.7 5.9 5.7 22.7 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 GAGA_bind PF06217.7 CDI76526.1 - 5.1 6.9 27.6 6 6.7 19.1 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family HemX PF04375.9 CDI76526.1 - 5.2 5.5 44.6 6.4 5.2 30.9 1.0 1 0 0 1 1 1 0 HemX Macoilin PF09726.4 CDI76526.1 - 5.3 5.2 26.2 6.3 4.9 18.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Herpes_DNAp_acc PF04929.7 CDI76526.1 - 6 5.7 21.0 6.7 5.5 14.5 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor MMR1 PF08505.5 CDI76526.1 - 6.2 6.7 33.8 7.5 6.5 23.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pilt PF15453.1 CDI76526.1 - 6.5 6.3 29.0 7.6 6.1 20.1 1.0 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions Gag_spuma PF03276.9 CDI76526.1 - 6.6 4.9 38.7 10 4.3 26.9 1.4 1 0 0 1 1 1 0 Spumavirus gag protein DHHW PF14286.1 CDI76526.1 - 6.8 5.8 22.0 9.9 5.3 15.2 1.4 1 0 0 1 1 1 0 DHHW protein DUF3450 PF11932.3 CDI76526.1 - 6.9 5.8 46.0 9.2 5.4 31.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DDRGK PF09756.4 CDI76526.1 - 7.3 5.9 37.1 9.2 5.6 25.7 1.1 1 0 0 1 1 1 0 DDRGK domain Presenilin PF01080.12 CDI76526.1 - 7.4 5.2 25.4 8.6 5.0 17.6 1.0 1 0 0 1 1 1 0 Presenilin APG6 PF04111.7 CDI76526.1 - 7.6 5.4 28.9 8.1 5.3 20.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 PCEMA1 PF07418.6 CDI76526.1 - 7.6 5.8 16.0 8.5 5.6 11.1 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 MRP-S31 PF15433.1 CDI76526.1 - 8.3 5.7 30.8 9.7 5.5 21.3 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 MSP1_C PF07462.6 CDI76526.1 - 8.5 4.6 15.8 8.6 4.6 11.0 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus FliP PF00813.15 CDI76526.1 - 9 5.9 15.4 11 5.6 10.7 1.1 1 0 0 1 1 1 0 FliP family Peptidase_S64 PF08192.6 CDI76526.1 - 10 4.3 26.6 12 4.1 18.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 zf-B_box PF00643.19 CDI76527.1 - 0.00024 20.9 6.6 0.00048 19.9 4.6 1.5 1 0 0 1 1 1 1 B-box zinc finger Zip PF02535.17 CDI76529.1 - 0.018 14.0 7.3 0.13 11.2 4.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Allexi_40kDa PF05549.6 CDI76529.1 - 0.02 14.1 0.3 0.02 14.1 0.2 3.2 3 1 1 4 4 2 0 Allexivirus 40kDa protein Med15 PF09606.5 CDI76529.1 - 0.02 13.1 67.1 0.0035 15.6 2.9 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI76529.1 - 0.033 11.9 20.8 0.67 7.6 0.0 2.2 2 0 0 2 2 2 0 Ycf1 LMBR1 PF04791.11 CDI76529.1 - 0.034 12.7 8.4 0.038 12.5 2.6 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein Spt20 PF12090.3 CDI76529.1 - 0.041 13.2 0.1 0.041 13.2 0.0 3.6 2 1 0 2 2 1 0 Spt20 family TFIIA PF03153.8 CDI76529.1 - 0.054 13.3 43.3 0.046 13.6 18.7 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ABC2_membrane_2 PF12679.2 CDI76529.1 - 0.21 10.4 2.9 0.73 8.6 0.0 2.4 3 0 0 3 3 3 0 ABC-2 family transporter protein Raftlin PF15250.1 CDI76529.1 - 0.25 9.8 20.5 0.32 9.4 8.7 2.2 2 0 0 2 2 2 0 Raftlin Band_3_cyto PF07565.8 CDI76529.1 - 0.3 10.5 22.5 0.19 11.2 7.2 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain RNA_pol_Rpb1_5 PF04998.12 CDI76529.1 - 0.44 9.7 11.4 3.8 6.6 6.2 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 5 Mem_trans PF03547.13 CDI76529.1 - 0.61 8.3 8.9 1 7.5 1.1 2.3 2 0 0 2 2 2 0 Membrane transport protein SOBP PF15279.1 CDI76529.1 - 0.7 10.2 19.2 3.9 7.7 7.3 2.3 2 0 0 2 2 2 0 Sine oculis-binding protein RR_TM4-6 PF06459.7 CDI76529.1 - 1.8 8.3 42.0 0.49 10.2 18.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF1943 PF09172.6 CDI76529.1 - 2.8 6.7 19.0 0.87 8.3 1.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) Pex26 PF07163.7 CDI76529.1 - 2.9 6.7 23.3 0.42 9.4 1.9 2.7 3 0 0 3 3 2 0 Pex26 protein AAA_11 PF13086.1 CDI76529.1 - 3.6 7.0 26.5 7.5 6.0 11.6 2.5 2 0 0 2 2 2 0 AAA domain U79_P34 PF03064.11 CDI76529.1 - 3.7 7.0 22.0 3 7.3 9.9 2.2 2 0 0 2 2 2 0 HSV U79 / HCMV P34 FAM60A PF15396.1 CDI76529.1 - 4.9 6.8 22.0 3.4 7.3 7.7 2.4 2 0 0 2 2 2 0 Protein Family FAM60A TT_ORF1 PF02956.9 CDI76529.1 - 7 4.9 12.5 0.78 8.1 3.3 2.0 2 0 0 2 2 2 0 TT viral orf 1 DUF4045 PF13254.1 CDI76529.1 - 7.9 5.6 28.5 0.87 8.7 10.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Caldesmon PF02029.10 CDI76529.1 - 9.8 4.4 34.4 0.47 8.8 15.3 2.3 2 0 0 2 2 2 0 Caldesmon Methyltransf_16 PF10294.4 CDI76530.1 - 1.4e-11 44.1 0.0 5.5e-06 25.9 0.0 3.7 4 0 0 4 4 4 3 Putative methyltransferase TraT PF05818.7 CDI76530.1 - 0.88 8.9 3.6 1.4 8.2 2.5 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF3357 PF11837.3 CDI76531.1 - 0.086 12.6 6.0 5.2 6.9 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) PLRV_ORF5 PF01690.12 CDI76531.1 - 3.7 6.6 21.6 5.5 6.0 14.9 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Exonuc_VII_L PF02601.10 CDI76531.1 - 6.2 5.9 24.7 10 5.1 17.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mob1_phocein PF03637.12 CDI76532.1 - 5.8e-10 39.1 0.4 1.6e-09 37.7 0.0 1.7 1 1 1 2 2 2 1 Mob1/phocein family DUF3643 PF12356.3 CDI76532.1 - 0.0013 18.1 0.5 0.0029 16.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3643) LIN37 PF15306.1 CDI76532.1 - 0.038 13.9 5.1 0.18 11.8 0.8 2.2 2 0 0 2 2 2 0 LIN37 DUF2269 PF10027.4 CDI76532.1 - 0.051 13.3 0.6 0.051 13.3 0.4 1.9 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) DUF2839 PF10999.3 CDI76532.1 - 0.21 11.6 0.0 0.21 11.6 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2839) Spt20 PF12090.3 CDI76532.1 - 0.23 10.7 10.3 1.8 7.9 1.4 2.2 2 0 0 2 2 2 0 Spt20 family FimP PF09766.4 CDI76532.1 - 0.45 9.5 17.3 0.35 9.8 3.9 2.1 2 0 0 2 2 2 0 Fms-interacting protein Serinc PF03348.10 CDI76532.1 - 0.49 9.0 8.2 2 7.0 1.6 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) Pex16 PF08610.5 CDI76532.1 - 0.5 9.3 11.4 0.15 11.0 1.7 2.1 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) FHIPEP PF00771.15 CDI76532.1 - 0.95 7.7 6.9 0.61 8.3 0.6 2.0 2 0 0 2 2 2 0 FHIPEP family Folliculin PF11704.3 CDI76532.1 - 1.4 8.5 7.7 1.7 8.1 0.5 2.3 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport EIIBC-GUT_N PF03612.9 CDI76532.1 - 7.9 6.0 7.8 6.2 6.4 0.5 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Hus1 PF04005.7 CDI76533.1 - 2.6e-10 39.7 0.0 2.1e-08 33.5 0.0 2.1 1 1 1 2 2 2 2 Hus1-like protein Spc97_Spc98 PF04130.8 CDI76534.1 - 4.9e-15 54.8 1.2 4.9e-15 54.8 0.9 4.9 4 1 1 5 5 5 2 Spc97 / Spc98 family DUF1183 PF06682.7 CDI76534.1 - 0.0055 16.3 1.0 0.0055 16.3 0.7 9.5 10 1 0 10 10 10 1 Protein of unknown function (DUF1183) TerC PF03741.11 CDI76534.1 - 0.53 9.6 2.6 2.6 7.4 0.0 3.3 4 0 0 4 4 4 0 Integral membrane protein TerC family VHS PF00790.14 CDI76535.1 - 0.0043 16.6 0.0 0.0082 15.7 0.0 1.5 1 0 0 1 1 1 1 VHS domain SET PF00856.23 CDI76536.1 - 1.4 9.1 5.3 1.6 9.0 0.0 2.5 2 1 0 2 2 2 0 SET domain MT PF12777.2 CDI76537.1 - 0.23 10.1 5.2 3.6 6.2 0.6 2.2 1 1 1 2 2 2 0 Microtubule-binding stalk of dynein motor MAS20 PF02064.10 CDI76539.1 - 0.019 14.8 0.7 0.042 13.7 0.0 1.9 2 0 0 2 2 2 0 MAS20 protein import receptor DUF2681 PF10883.3 CDI76539.1 - 0.15 12.3 0.2 0.15 12.3 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) DUF1510 PF07423.6 CDI76539.1 - 3.7 6.8 8.8 2.6 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) CALCOCO1 PF07888.6 CDI76540.1 - 0.003 15.9 7.1 0.0049 15.2 4.9 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Paramyx_P_V_C PF03210.8 CDI76540.1 - 0.034 14.0 0.1 0.4 10.5 0.0 2.2 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal Reo_sigmaC PF04582.7 CDI76540.1 - 0.067 12.3 1.2 0.093 11.8 0.8 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein GAS PF13851.1 CDI76540.1 - 0.087 12.0 8.2 0.18 11.0 5.7 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TEX13 PF15186.1 CDI76540.1 - 0.24 10.9 4.1 0.16 11.5 1.5 1.7 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family APG6 PF04111.7 CDI76540.1 - 1.7 7.6 9.0 3.4 6.6 6.2 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 PT PF04886.7 CDI76540.1 - 3.1 7.1 11.1 0.063 12.5 2.7 2.0 2 0 0 2 2 2 0 PT repeat IncA PF04156.9 CDI76540.1 - 5.6 6.5 18.2 0.22 11.1 6.1 2.8 2 1 1 3 3 3 0 IncA protein NYD-SP28_assoc PF14775.1 CDI76540.1 - 8 6.2 7.5 4.6 7.0 0.1 3.0 3 0 0 3 3 3 0 Sperm tail C-terminal domain DivIC PF04977.10 CDI76540.1 - 8.8 5.8 15.2 0.22 11.0 0.9 3.2 3 1 1 4 4 4 0 Septum formation initiator NUC173 PF08161.7 CDI76541.1 - 1.4e-15 57.2 0.2 1.4e-14 53.8 0.0 3.0 4 0 0 4 4 4 1 NUC173 domain Vpu PF00558.14 CDI76541.1 - 0.36 10.4 2.1 0.72 9.4 0.8 2.1 1 1 0 1 1 1 0 Vpu protein DUF3458 PF11940.3 CDI76542.1 - 3.5e-95 318.9 0.4 5.2e-95 318.3 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Peptidase_M1 PF01433.15 CDI76542.1 - 6.3e-53 180.2 0.0 9e-53 179.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Peptidase_MA_2 PF13485.1 CDI76542.1 - 3.3e-15 56.2 0.1 8.4e-15 54.9 0.1 1.7 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 CDI76542.1 - 0.047 13.6 2.7 0.32 10.9 1.0 2.8 2 1 0 2 2 2 0 M61 glycyl aminopeptidase Lactamase_B_2 PF12706.2 CDI76545.1 - 4.3e-17 62.3 0.0 4.7e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 CDI76545.1 - 0.05 13.2 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily PAT1 PF09770.4 CDI76546.1 - 0.31 9.2 49.5 0.31 9.2 34.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MIP-T3 PF10243.4 CDI76546.1 - 0.32 9.4 41.3 0.34 9.3 28.6 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Med15 PF09606.5 CDI76546.1 - 0.5 8.5 59.3 0.51 8.4 41.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4175 PF13779.1 CDI76546.1 - 0.94 7.1 50.4 1.2 6.7 35.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SAGA-Tad1 PF12767.2 CDI76546.1 - 0.94 9.0 30.4 1.3 8.6 21.1 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Nha1_C PF08619.5 CDI76546.1 - 1.6 7.8 33.2 1.8 7.7 23.0 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Macoilin PF09726.4 CDI76546.1 - 5.1 5.2 42.3 5.5 5.1 29.3 1.0 1 0 0 1 1 1 0 Transmembrane protein DNA_pol_viral_N PF00242.12 CDI76546.1 - 5.3 5.9 43.6 5.8 5.8 30.2 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Lactamase_B_4 PF13691.1 CDI76547.1 - 1.4e-07 30.8 0.0 4e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 tRNase Z endonuclease CDK5_activator PF03261.10 CDI76547.1 - 7.8 5.7 12.8 11 5.1 8.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SAPS PF04499.10 CDI76549.1 - 0.001 17.8 1.0 0.001 17.7 0.7 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein LMBR1 PF04791.11 CDI76549.1 - 0.27 9.7 0.9 0.57 8.6 0.7 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein Band_3_cyto PF07565.8 CDI76549.1 - 0.27 10.6 11.3 0.46 9.9 7.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spore_coat_CotO PF14153.1 CDI76549.1 - 0.44 9.9 18.5 0.64 9.4 12.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DHHW PF14286.1 CDI76549.1 - 1.2 8.3 9.0 1.9 7.7 6.3 1.2 1 0 0 1 1 1 0 DHHW protein Suf PF05843.9 CDI76549.1 - 1.5 8.5 21.1 2.4 7.8 14.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI76549.1 - 2.2 6.4 37.3 2.7 6.1 25.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.8 CDI76549.1 - 4.5 7.3 24.3 15 5.5 13.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3446 PF11928.3 CDI76549.1 - 6.8 6.9 11.8 0.68 10.1 3.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) OmpH PF03938.9 CDI76550.1 - 6.8e-10 39.1 17.9 6.8e-10 39.1 12.4 15.2 9 6 2 11 11 11 2 Outer membrane protein (OmpH-like) Pribosyltran PF00156.22 CDI76550.1 - 0.12 12.1 0.1 18 5.0 0.0 4.2 2 0 0 2 2 2 0 Phosphoribosyl transferase domain MIP-T3 PF10243.4 CDI76551.1 - 1.8 6.9 32.3 2.2 6.6 22.4 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 ThiF PF00899.16 CDI76554.1 - 1.3e-37 128.6 0.1 2.3e-37 127.8 0.1 1.4 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 CDI76554.1 - 0.00012 21.6 0.4 0.0022 17.5 0.3 2.6 1 1 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 CDI76554.1 - 0.00037 20.8 0.0 0.022 15.0 0.0 3.4 3 1 0 3 3 3 1 Rhodanese-like domain Shikimate_DH PF01488.15 CDI76554.1 - 0.017 15.2 0.1 0.05 13.7 0.0 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Corona_nucleoca PF00937.13 CDI76554.1 - 4.1 6.2 9.8 6.1 5.6 6.8 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Cupin_8 PF13621.1 CDI76555.1 - 0.0071 15.8 0.1 0.023 14.2 0.0 1.8 2 0 0 2 2 2 1 Cupin-like domain DUF605 PF04652.11 CDI76555.1 - 0.17 11.2 25.2 0.18 11.2 8.3 2.3 2 0 0 2 2 2 0 Vta1 like DUF4557 PF15101.1 CDI76555.1 - 4 7.2 10.0 1.6 8.5 5.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Dsh_C PF12316.3 CDI76559.1 - 3 7.8 47.1 1 9.4 16.6 2.3 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Hydrolase PF00702.21 CDI76560.1 - 1.4 9.3 12.6 2.4 8.5 8.7 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase CTP_transf_2 PF01467.21 CDI76561.1 - 1.5e-15 57.5 0.3 1.8e-06 28.1 0.1 3.1 1 1 2 3 3 3 2 Cytidylyltransferase Ycf1 PF05758.7 CDI76561.1 - 0.037 11.7 7.6 0.05 11.3 5.2 1.2 1 0 0 1 1 1 0 Ycf1 Presenilin PF01080.12 CDI76561.1 - 0.12 11.2 8.8 0.084 11.6 1.3 2.1 2 0 0 2 2 2 0 Presenilin Shadoo PF14999.1 CDI76561.1 - 0.32 10.8 8.5 0.75 9.6 5.9 1.6 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective eIF-3_zeta PF05091.7 CDI76561.1 - 0.42 9.1 13.0 0.73 8.3 9.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Tim54 PF11711.3 CDI76561.1 - 0.81 8.2 9.7 0.26 9.8 4.2 1.8 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.9 CDI76561.1 - 0.96 7.3 12.2 0.16 9.9 5.3 1.8 2 0 0 2 2 2 0 CDC45-like protein DUF2360 PF10152.4 CDI76561.1 - 1.8 8.8 18.4 6.3 7.0 8.2 2.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) HORMA PF02301.13 CDI76562.1 - 2.1e-07 30.6 0.0 2.1e-07 30.6 0.0 2.9 2 1 0 3 3 3 1 HORMA domain Ldh_1_C PF02866.13 CDI76562.1 - 0.0017 18.0 0.8 0.0017 18.0 0.5 2.8 2 1 1 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ribosomal_60s PF00428.14 CDI76562.1 - 1.1 9.7 27.1 1.3 9.4 5.9 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF572 PF04502.8 CDI76562.1 - 2.4 7.2 41.2 0.46 9.6 23.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Asp-B-Hydro_N PF05279.6 CDI76562.1 - 5.1 6.8 19.5 3.3 7.4 8.7 2.4 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region DUF342 PF03961.8 CDI76562.1 - 5.9 5.1 15.1 11 4.3 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) N6_N4_Mtase PF01555.13 CDI76563.1 - 0.0013 18.2 0.0 0.0019 17.7 0.0 1.4 1 1 0 1 1 1 1 DNA methylase U1snRNP70_N PF12220.3 CDI76563.1 - 0.1 12.9 16.3 0.11 12.7 4.1 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SR-25 PF10500.4 CDI76563.1 - 0.1 12.0 11.7 0.13 11.7 8.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FimP PF09766.4 CDI76563.1 - 0.33 9.9 20.5 0.12 11.4 4.7 2.1 2 0 0 2 2 2 0 Fms-interacting protein DDHD PF02862.12 CDI76563.1 - 0.54 10.0 10.4 0.6 9.8 7.2 1.1 1 0 0 1 1 1 0 DDHD domain DUF4512 PF14975.1 CDI76563.1 - 0.71 10.7 4.2 0.62 10.9 1.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4512) Peptidase_S49_N PF08496.5 CDI76563.1 - 0.78 9.5 8.9 0.065 13.0 0.4 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PAT1 PF09770.4 CDI76563.1 - 3.6 5.7 42.3 3.9 5.5 29.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 dsDNA_bind PF01984.15 CDI76563.1 - 7.8 6.5 31.4 0.15 12.0 6.3 2.4 2 0 0 2 2 2 0 Double-stranded DNA-binding domain ERF PF04404.7 CDI76563.1 - 9.7 5.6 22.5 0.24 10.9 4.1 2.2 2 0 0 2 2 2 0 ERF superfamily RtcB PF01139.12 CDI76564.1 - 6.5e-109 364.7 0.1 1.1e-92 311.2 0.0 5.3 4 1 1 5 5 5 2 tRNA-splicing ligase RtcB Apt1 PF10351.4 CDI76565.1 - 0.23 10.2 15.0 0.24 10.2 10.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DMAP_binding PF06464.6 CDI76565.1 - 0.31 11.6 4.9 0.5 10.9 3.4 1.3 1 0 0 1 1 1 0 DMAP1-binding Domain Pex16 PF08610.5 CDI76565.1 - 0.4 9.6 4.2 0.49 9.3 2.9 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Macoilin PF09726.4 CDI76565.1 - 0.46 8.7 21.0 0.45 8.7 14.6 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1980 PF09323.5 CDI76565.1 - 0.95 9.1 3.2 1.2 8.8 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Sec3_C PF09763.4 CDI76565.1 - 1.5 6.8 9.8 1.5 6.8 6.8 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 YMF19 PF02326.10 CDI76565.1 - 1.7 9.2 4.7 3.1 8.4 3.3 1.5 1 1 0 1 1 1 0 Plant ATP synthase F0 RAP1 PF07218.6 CDI76565.1 - 2.9 5.8 27.7 3.5 5.6 19.2 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF822 PF05687.8 CDI76565.1 - 3.1 8.1 13.0 3.8 7.8 9.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF822) DUF605 PF04652.11 CDI76565.1 - 3.2 7.0 12.5 3.5 6.9 8.6 1.1 1 0 0 1 1 1 0 Vta1 like FancD2 PF14631.1 CDI76565.1 - 3.3 4.7 7.1 3.5 4.5 4.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Presenilin PF01080.12 CDI76565.1 - 4.5 6.0 8.2 5.1 5.8 5.7 1.1 1 0 0 1 1 1 0 Presenilin DUF566 PF04484.7 CDI76565.1 - 4.6 6.6 20.5 5.3 6.4 14.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) CobT PF06213.7 CDI76565.1 - 4.7 6.2 7.6 5.5 6.0 5.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CytochromB561_N PF09786.4 CDI76565.1 - 5 5.4 16.8 4.7 5.5 11.6 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DUF1675 PF07897.6 CDI76565.1 - 6.3 6.5 14.6 7.3 6.3 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) BUD22 PF09073.5 CDI76565.1 - 6.7 5.6 12.4 8.5 5.3 8.6 1.2 1 0 0 1 1 1 0 BUD22 GCV_T PF01571.16 CDI76567.1 - 1.9e-05 24.1 0.0 0.011 15.1 0.0 2.6 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 CDI76567.1 - 5e-05 23.2 3.2 0.0014 18.5 0.0 3.5 3 0 0 3 3 3 1 Glycine cleavage T-protein C-terminal barrel domain Spt20 PF12090.3 CDI76568.1 - 0.0078 15.5 1.2 0.0078 15.5 0.8 1.1 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.8 CDI76568.1 - 0.0087 16.1 1.6 0.011 15.8 1.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Herpes_UL3 PF03369.8 CDI76568.1 - 0.026 14.4 2.9 0.033 14.1 2.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL3 protein DUF3260 PF11658.3 CDI76568.1 - 0.038 12.1 1.6 0.047 11.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) UPF0233 PF06781.7 CDI76568.1 - 0.041 13.5 0.1 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) DUF2147 PF09917.4 CDI76568.1 - 0.053 13.7 0.4 0.064 13.5 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2147) DUF1525 PF07511.6 CDI76568.1 - 0.06 13.3 6.2 0.075 13.0 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Suf PF05843.9 CDI76568.1 - 0.12 12.0 2.7 0.13 11.9 1.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Mus7 PF09462.5 CDI76568.1 - 0.14 10.9 5.3 0.17 10.7 3.7 1.0 1 0 0 1 1 1 0 Mus7/MMS22 family Med15 PF09606.5 CDI76568.1 - 0.16 10.1 18.6 0.17 10.0 12.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal UPF0560 PF10577.4 CDI76568.1 - 0.33 9.1 6.2 0.36 9.0 4.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RAB3GAP2_N PF14655.1 CDI76568.1 - 0.42 9.5 9.8 0.63 8.9 6.7 1.3 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus SprA-related PF12118.3 CDI76568.1 - 0.71 9.1 12.0 0.83 8.9 8.3 1.1 1 0 0 1 1 1 0 SprA-related family DUF4175 PF13779.1 CDI76568.1 - 1.5 6.4 13.9 1.5 6.3 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DivIC PF04977.10 CDI76568.1 - 2.5 7.6 9.8 3.8 7.0 6.8 1.3 1 0 0 1 1 1 0 Septum formation initiator Med3 PF11593.3 CDI76568.1 - 6.2 5.9 16.6 7.6 5.6 11.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Activator_LAG-3 PF11498.3 CDI76568.1 - 8.1 5.0 23.7 8.9 4.9 16.4 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med15 PF09606.5 CDI76570.1 - 0.27 9.3 36.7 1.1 7.3 19.2 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Serinc PF03348.10 CDI76572.1 - 2.9e-05 22.9 1.1 3.1e-05 22.9 0.7 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Med15 PF09606.5 CDI76572.1 - 7.6e-05 21.1 28.8 8.9e-05 20.9 20.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI76572.1 - 0.0011 18.7 5.7 0.0012 18.6 3.9 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) SprA-related PF12118.3 CDI76572.1 - 0.0026 17.1 20.9 0.003 16.9 14.5 1.2 1 0 0 1 1 1 1 SprA-related family Shisa PF13908.1 CDI76572.1 - 0.0029 17.8 3.9 0.0038 17.4 2.7 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FPN1 PF06963.7 CDI76572.1 - 0.005 15.2 2.2 0.0068 14.8 1.5 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Peptidase_S49_N PF08496.5 CDI76572.1 - 0.0074 16.0 3.5 0.01 15.6 2.5 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DUF4557 PF15101.1 CDI76572.1 - 0.008 16.0 12.9 0.0094 15.8 8.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4557) Hid1 PF12722.2 CDI76572.1 - 0.01 13.5 2.4 0.011 13.4 1.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AUX_IAA PF02309.11 CDI76572.1 - 0.016 14.9 1.1 0.017 14.8 0.8 1.1 1 0 0 1 1 1 0 AUX/IAA family Gag_spuma PF03276.9 CDI76572.1 - 0.023 13.0 21.3 0.029 12.7 14.8 1.1 1 0 0 1 1 1 0 Spumavirus gag protein TFIIA PF03153.8 CDI76572.1 - 0.026 14.4 16.4 0.027 14.3 11.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OATP PF03137.15 CDI76572.1 - 0.035 12.1 2.9 0.045 11.8 2.0 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF1980 PF09323.5 CDI76572.1 - 0.052 13.2 0.7 0.071 12.8 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Presenilin PF01080.12 CDI76572.1 - 0.071 11.9 2.0 0.082 11.7 1.4 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.12 CDI76572.1 - 0.073 12.8 2.8 0.085 12.6 1.9 1.2 1 0 0 1 1 1 0 DDHD domain DUF4446 PF14584.1 CDI76572.1 - 0.093 12.5 4.1 0.16 11.7 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) RR_TM4-6 PF06459.7 CDI76572.1 - 0.12 12.2 3.1 0.13 12.1 2.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2217 PF10265.4 CDI76572.1 - 0.14 10.9 3.8 0.16 10.6 2.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) HemX PF04375.9 CDI76572.1 - 0.15 10.6 24.6 0.2 10.2 17.0 1.1 1 0 0 1 1 1 0 HemX Prok-JAB PF14464.1 CDI76572.1 - 0.15 11.6 2.9 0.25 10.9 2.0 1.4 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain Pex14_N PF04695.8 CDI76572.1 - 0.16 12.0 15.4 0.24 11.4 10.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FimP PF09766.4 CDI76572.1 - 0.16 10.9 14.2 0.2 10.7 9.9 1.1 1 0 0 1 1 1 0 Fms-interacting protein Neur_chan_memb PF02932.11 CDI76572.1 - 0.18 11.6 2.5 0.24 11.2 1.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2232 PF09991.4 CDI76572.1 - 0.23 10.4 3.1 0.32 9.9 2.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Baculo_PP31 PF05311.6 CDI76572.1 - 0.27 10.4 6.6 0.33 10.1 4.6 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF3450 PF11932.3 CDI76572.1 - 0.28 10.4 26.4 0.37 10.0 18.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FliP PF00813.15 CDI76572.1 - 0.32 10.6 4.6 0.43 10.2 3.2 1.1 1 0 0 1 1 1 0 FliP family UPF0560 PF10577.4 CDI76572.1 - 0.35 9.0 15.2 0.43 8.7 10.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PAT1 PF09770.4 CDI76572.1 - 0.54 8.4 26.6 0.64 8.1 18.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2215 PF10225.4 CDI76572.1 - 0.59 9.5 3.6 0.76 9.1 2.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) AIF_C PF14721.1 CDI76572.1 - 0.6 10.3 6.1 0.87 9.8 4.2 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TMEM51 PF15345.1 CDI76572.1 - 1.2 8.8 13.5 1.9 8.1 9.3 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Peptidase_U57 PF05582.7 CDI76572.1 - 1.4 7.8 7.0 1.9 7.3 4.8 1.1 1 0 0 1 1 1 0 YabG peptidase U57 GNT-I PF03071.10 CDI76572.1 - 1.4 7.3 7.7 1.7 7.0 5.3 1.0 1 0 0 1 1 1 0 GNT-I family Gastrin PF00918.12 CDI76572.1 - 1.6 9.5 18.8 1.8 9.4 12.5 1.5 1 1 0 1 1 1 0 Gastrin/cholecystokinin family DUF3617 PF12276.3 CDI76572.1 - 1.8 8.0 11.8 3.3 7.1 8.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) PMSI1 PF15322.1 CDI76572.1 - 2 7.4 9.9 3.1 6.7 6.8 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Spore_III_AF PF09581.5 CDI76572.1 - 2.1 8.1 7.5 4.4 7.1 5.2 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF3260 PF11658.3 CDI76572.1 - 2.2 6.3 9.1 2.7 6.0 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) DDRGK PF09756.4 CDI76572.1 - 2.3 7.5 15.2 3.1 7.1 10.5 1.1 1 0 0 1 1 1 0 DDRGK domain DUF2422 PF10337.4 CDI76572.1 - 2.4 6.8 10.4 3.6 6.2 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Carot_N PF09150.5 CDI76572.1 - 2.4 7.8 11.7 1.5 8.4 6.8 1.5 1 1 1 2 2 1 0 Orange carotenoid protein, N-terminal OAD_gamma PF04277.8 CDI76572.1 - 3.3 8.1 8.4 0.31 11.4 0.7 2.3 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF3533 PF12051.3 CDI76572.1 - 4.2 6.0 7.2 5.3 5.6 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) eIF-3_zeta PF05091.7 CDI76572.1 - 4.4 5.7 14.6 5 5.6 10.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_23 PF13476.1 CDI76572.1 - 4.8 7.4 10.6 5.8 7.1 7.3 1.1 1 0 0 1 1 1 0 AAA domain Med13_N PF11597.3 CDI76572.1 - 9.8 4.7 11.4 13 4.3 7.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal PAP2_C PF14360.1 CDI76573.1 - 2.6e-07 30.7 2.6 5.3e-07 29.8 1.8 1.5 1 0 0 1 1 1 1 PAP2 superfamily C-terminal RAB3GAP2_N PF14655.1 CDI76575.1 - 0.03 13.3 0.5 0.047 12.6 0.3 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Myco_19_kDa PF05481.7 CDI76575.1 - 0.12 12.1 3.8 0.18 11.6 2.7 1.2 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen SprA-related PF12118.3 CDI76575.1 - 1.9 7.7 14.3 5.2 6.2 6.8 2.0 2 0 0 2 2 2 0 SprA-related family BAF1_ABF1 PF04684.8 CDI76575.1 - 2.2 7.0 8.1 3.1 6.5 5.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Pex14_N PF04695.8 CDI76575.1 - 4.3 7.3 10.9 2 8.4 1.1 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GTP_EFTU_D3 PF03143.12 CDI76579.1 - 2e-20 72.8 0.1 3.1e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CDI76579.1 - 0.12 12.4 0.1 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu domain 2 PA26 PF04636.8 CDI76580.1 - 0.14 10.8 3.7 0.19 10.3 2.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Draxin PF15550.1 CDI76580.1 - 0.16 11.6 3.4 0.19 11.3 2.4 1.1 1 0 0 1 1 1 0 Draxin FAM176 PF14851.1 CDI76580.1 - 0.33 10.6 3.7 0.48 10.0 2.6 1.2 1 0 0 1 1 1 0 FAM176 family HAUS6_N PF14661.1 CDI76580.1 - 4.6 6.5 11.3 7.2 5.8 7.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus rve PF00665.21 CDI76581.1 - 3e-08 33.8 0.0 1.1e-07 32.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 CDI76582.1 - 7.1e-05 22.2 0.0 0.00015 21.2 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.17 CDI76583.1 - 2.7e-29 100.5 0.2 7.3e-15 54.3 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76583.1 - 8.3e-23 80.1 0.1 1.2e-11 44.3 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76583.1 - 2e-09 37.1 0.1 0.0014 18.4 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 CDI76583.1 - 0.0029 17.0 0.1 0.12 11.8 0.0 2.4 2 0 0 2 2 2 1 Ribonuclease B OB domain SR-25 PF10500.4 CDI76583.1 - 0.055 12.9 1.8 0.11 11.9 1.3 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Chorein_N PF12624.2 CDI76585.1 - 1.3e-18 66.6 0.9 4.6e-18 64.8 0.0 2.2 2 0 0 2 2 2 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Kinesin PF00225.18 CDI76586.1 - 6.8e-67 225.5 2.3 1.1e-64 218.2 0.1 3.3 2 1 0 2 2 2 1 Kinesin motor domain Haemolytic PF01809.13 CDI76586.1 - 0.12 12.0 1.1 0.24 11.0 0.7 1.4 1 0 0 1 1 1 0 Haemolytic domain Peptidase_S64 PF08192.6 CDI76587.1 - 3 6.0 12.3 3 6.0 8.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF1675 PF07897.6 CDI76587.1 - 3.5 7.4 18.5 4.1 7.1 12.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Ashwin PF15323.1 CDI76587.1 - 3.6 7.5 20.2 4.3 7.2 14.0 1.3 1 0 0 1 1 1 0 Developmental protein ATP_bind_3 PF01171.15 CDI76589.1 - 1.4e-07 31.1 0.0 4.1e-06 26.4 0.0 2.3 1 1 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 CDI76589.1 - 0.0044 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) DUF4175 PF13779.1 CDI76589.1 - 7.9 4.0 10.5 12 3.4 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) zf-C2H2_4 PF13894.1 CDI76591.1 - 0.00017 21.6 3.2 0.21 11.9 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDI76591.1 - 0.0015 18.6 0.4 0.0015 18.6 0.2 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding DUF1510 PF07423.6 CDI76591.1 - 0.0047 16.3 15.4 0.0062 15.9 10.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) CDC45 PF02724.9 CDI76591.1 - 0.0049 14.9 11.6 0.0063 14.6 8.0 1.0 1 0 0 1 1 1 1 CDC45-like protein BTV_NS2 PF04514.7 CDI76591.1 - 0.01 14.7 8.7 0.013 14.4 6.1 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Plasmodium_Vir PF05795.6 CDI76591.1 - 0.011 14.9 2.3 0.016 14.4 1.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein UPF0560 PF10577.4 CDI76591.1 - 0.011 14.0 7.4 0.014 13.7 5.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Pex14_N PF04695.8 CDI76591.1 - 0.013 15.5 12.1 0.027 14.5 8.4 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.3 CDI76591.1 - 0.013 14.1 9.0 0.017 13.7 6.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ycf1 PF05758.7 CDI76591.1 - 0.013 13.2 16.7 0.017 12.8 11.6 1.0 1 0 0 1 1 1 0 Ycf1 GAGA_bind PF06217.7 CDI76591.1 - 0.019 14.9 13.0 0.027 14.4 9.0 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Band_3_cyto PF07565.8 CDI76591.1 - 0.021 14.3 8.9 0.027 13.9 6.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SUFU_C PF12470.3 CDI76591.1 - 0.035 13.7 5.3 0.05 13.2 3.6 1.1 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain DUF2201_N PF13203.1 CDI76591.1 - 0.047 12.8 12.4 0.064 12.4 8.6 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain AAA_23 PF13476.1 CDI76591.1 - 0.06 13.6 17.2 0.078 13.2 11.9 1.2 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 CDI76591.1 - 0.061 12.8 10.8 0.092 12.3 7.5 1.2 1 0 0 1 1 1 0 AAA domain Anoctamin PF04547.7 CDI76591.1 - 0.061 11.9 3.0 0.073 11.7 2.1 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel DDRGK PF09756.4 CDI76591.1 - 0.064 12.6 28.5 0.082 12.3 19.8 1.1 1 0 0 1 1 1 0 DDRGK domain Suf PF05843.9 CDI76591.1 - 0.079 12.6 14.4 0.1 12.3 10.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.5 CDI76591.1 - 0.08 11.3 5.8 0.091 11.1 4.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SpoVR PF04293.8 CDI76591.1 - 0.086 11.1 13.0 0.12 10.7 9.0 1.1 1 0 0 1 1 1 0 SpoVR like protein LMBR1 PF04791.11 CDI76591.1 - 0.087 11.3 5.0 0.11 11.0 3.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein tRNA-synt_2c PF01411.14 CDI76591.1 - 0.11 10.7 7.2 0.15 10.3 5.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class II (A) DDHD PF02862.12 CDI76591.1 - 0.12 12.1 13.0 0.17 11.6 9.0 1.1 1 0 0 1 1 1 0 DDHD domain LicD PF04991.8 CDI76591.1 - 0.12 12.4 2.4 0.17 12.0 1.7 1.2 1 0 0 1 1 1 0 LicD family SAPS PF04499.10 CDI76591.1 - 0.15 10.6 9.7 0.19 10.3 6.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RP-C_C PF11800.3 CDI76591.1 - 0.15 11.7 10.6 0.2 11.3 7.3 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region zf-C2H2 PF00096.21 CDI76591.1 - 0.16 12.3 4.3 0.69 10.3 0.2 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type RR_TM4-6 PF06459.7 CDI76591.1 - 0.17 11.7 17.9 0.24 11.2 12.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.7 CDI76591.1 - 0.18 10.4 15.8 0.23 10.0 10.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) zf-Di19 PF05605.7 CDI76591.1 - 0.18 11.9 4.5 0.79 9.8 3.1 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF3464 PF11947.3 CDI76591.1 - 0.2 11.0 12.7 0.37 10.2 8.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Pneumo_phosprot PF02478.11 CDI76591.1 - 0.21 11.0 8.1 0.32 10.4 5.6 1.2 1 0 0 1 1 1 0 Pneumovirus phosphoprotein Fmp27 PF10344.4 CDI76591.1 - 0.27 8.8 11.7 0.37 8.4 8.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 NARP1 PF12569.3 CDI76591.1 - 0.32 9.7 22.7 0.43 9.2 15.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TMEM51 PF15345.1 CDI76591.1 - 0.42 10.2 10.8 0.67 9.5 7.5 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 AUX_IAA PF02309.11 CDI76591.1 - 0.42 10.3 12.6 0.62 9.7 8.7 1.2 1 0 0 1 1 1 0 AUX/IAA family Kei1 PF08552.6 CDI76591.1 - 0.46 10.1 9.5 0.72 9.4 6.6 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Vfa1 PF08432.5 CDI76591.1 - 0.61 10.0 23.7 1.1 9.2 16.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.7 CDI76591.1 - 0.61 8.7 8.2 0.86 8.2 5.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Dicty_REP PF05086.7 CDI76591.1 - 1.1 6.9 8.1 1.3 6.7 5.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FLO_LFY PF01698.11 CDI76591.1 - 1.1 7.9 16.2 1.5 7.5 11.2 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein LIM_bind PF01803.11 CDI76591.1 - 1.2 8.1 12.5 2.3 7.2 8.7 1.4 1 0 0 1 1 1 0 LIM-domain binding protein CRT10 PF08728.5 CDI76591.1 - 1.3 6.9 6.8 1.5 6.6 4.7 1.0 1 0 0 1 1 1 0 CRT10 VID27 PF08553.5 CDI76591.1 - 1.3 7.1 14.5 1.7 6.7 10.1 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Hid1 PF12722.2 CDI76591.1 - 1.5 6.4 13.4 1.9 6.0 9.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.11 CDI76591.1 - 1.5 8.6 10.3 2.2 8.0 7.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OmpH PF03938.9 CDI76591.1 - 1.6 8.6 34.5 2.8 7.8 23.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RNase_H2-Ydr279 PF09468.5 CDI76591.1 - 1.8 7.6 12.9 2.5 7.2 8.9 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Cellulose_synt PF03552.9 CDI76591.1 - 2 6.5 6.3 2.6 6.2 4.4 1.1 1 0 0 1 1 1 0 Cellulose synthase HSP70 PF00012.15 CDI76591.1 - 2.1 6.1 14.5 2.8 5.7 10.0 1.1 1 0 0 1 1 1 0 Hsp70 protein Paf1 PF03985.8 CDI76591.1 - 3 6.5 21.0 3.9 6.0 14.6 1.1 1 0 0 1 1 1 0 Paf1 DUF4199 PF13858.1 CDI76591.1 - 3.1 7.6 5.2 5.3 6.9 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) EIIBC-GUT_N PF03612.9 CDI76591.1 - 3.8 7.0 8.9 7.1 6.2 6.2 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Atg14 PF10186.4 CDI76591.1 - 4.1 6.2 22.1 5.8 5.7 15.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Zip PF02535.17 CDI76591.1 - 5.3 5.9 9.0 0.97 8.3 3.2 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter YjgP_YjgQ PF03739.9 CDI76591.1 - 5.4 5.6 5.5 7 5.2 3.8 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Nucleoside_tran PF01733.13 CDI76591.1 - 5.7 6.0 5.8 7.9 5.5 4.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter DUF2126 PF09899.4 CDI76591.1 - 5.8 4.8 10.6 7.7 4.4 7.4 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF2072 PF09845.4 CDI76591.1 - 6.2 6.7 13.0 13 5.6 9.0 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) FAM176 PF14851.1 CDI76591.1 - 6.9 6.3 8.8 11 5.6 6.1 1.3 1 0 0 1 1 1 0 FAM176 family DHHW PF14286.1 CDI76591.1 - 7.6 5.7 12.9 10 5.3 8.9 1.1 1 0 0 1 1 1 0 DHHW protein OATP PF03137.15 CDI76591.1 - 7.8 4.4 7.3 11 3.9 5.0 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Herpes_DNAp_acc PF04929.7 CDI76591.1 - 8.1 5.2 14.4 11 4.8 10.0 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF4557 PF15101.1 CDI76591.1 - 8.7 6.1 29.6 12 5.6 20.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4557) Ribosomal_60s PF00428.14 CDI76593.1 - 0.019 15.3 14.7 0.034 14.5 0.2 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein SR-25 PF10500.4 CDI76593.1 - 0.62 9.4 15.8 0.89 8.9 6.0 2.5 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein ZU5 PF00791.15 CDI76594.1 - 0.42 10.3 3.4 5.8 6.6 0.0 2.5 2 0 0 2 2 2 0 ZU5 domain Apt1 PF10351.4 CDI76594.1 - 0.81 8.4 20.4 0.94 8.2 2.1 3.1 3 0 0 3 3 3 0 Golgi-body localisation protein domain DUF1645 PF07816.6 CDI76595.1 - 0.014 15.8 7.0 0.014 15.8 4.9 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) U1snRNP70_N PF12220.3 CDI76595.1 - 0.11 12.8 6.3 0.26 11.6 4.4 1.6 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Tim54 PF11711.3 CDI76595.1 - 5.2 5.5 5.5 42 2.5 0.0 2.8 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 DUF3292 PF11696.3 CDI76595.1 - 6.6 4.4 12.9 0.025 12.4 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) Gly_transf_sug PF04488.10 CDI76598.1 - 6.8e-07 29.6 0.0 2.2e-06 27.9 0.0 1.9 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif BCDHK_Adom3 PF10436.4 CDI76600.1 - 0.0011 18.5 0.0 0.0011 18.5 0.0 2.2 3 0 0 3 3 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Suf PF05843.9 CDI76600.1 - 0.043 13.5 19.9 0.26 10.9 2.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) CDK2AP PF09806.4 CDI76600.1 - 0.16 12.1 22.2 0.097 12.8 8.6 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Miff PF05644.6 CDI76600.1 - 0.19 11.3 12.2 0.25 10.9 4.2 2.1 2 0 0 2 2 2 0 Mitochondrial and peroxisomal fission factor Mff DUF4557 PF15101.1 CDI76600.1 - 0.3 10.8 30.8 0.51 10.1 8.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) TMEM51 PF15345.1 CDI76600.1 - 0.42 10.2 24.1 0.11 12.1 2.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 FimP PF09766.4 CDI76600.1 - 0.45 9.5 32.5 0.11 11.5 3.6 2.1 2 0 0 2 2 2 0 Fms-interacting protein TFIIA PF03153.8 CDI76600.1 - 0.48 10.2 32.9 0.57 10.0 3.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.8 CDI76600.1 - 0.62 10.1 26.6 1.3 9.1 7.9 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PRP3 PF08572.5 CDI76600.1 - 0.72 9.1 20.6 0.58 9.4 1.9 2.1 2 0 0 2 2 2 0 pre-mRNA processing factor 3 (PRP3) SAGA-Tad1 PF12767.2 CDI76600.1 - 0.73 9.4 21.4 0.97 9.0 6.3 2.1 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit BAF1_ABF1 PF04684.8 CDI76600.1 - 0.95 8.2 56.3 0.015 14.1 18.8 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor AUX_IAA PF02309.11 CDI76600.1 - 1.1 8.9 13.4 0.45 10.2 3.6 2.1 2 0 0 2 2 2 0 AUX/IAA family LIM_bind PF01803.11 CDI76600.1 - 1.1 8.3 20.8 0.37 9.8 1.8 2.3 2 0 0 2 2 2 0 LIM-domain binding protein FAM176 PF14851.1 CDI76600.1 - 1.3 8.6 14.1 5 6.7 0.2 2.2 2 0 0 2 2 2 0 FAM176 family Band_3_cyto PF07565.8 CDI76600.1 - 1.4 8.3 16.7 2.7 7.4 5.1 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain SLD3 PF08639.5 CDI76600.1 - 1.5 7.4 20.7 1.9 7.0 0.4 2.1 2 0 0 2 2 2 0 DNA replication regulator SLD3 Dala_Dala_lig_N PF01820.16 CDI76600.1 - 1.5 9.1 7.6 16 5.8 2.1 2.4 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus zf-DHHC PF01529.15 CDI76600.1 - 1.7 8.0 10.8 2.5 7.4 0.2 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase BORG_CEP PF14957.1 CDI76600.1 - 2.1 9.3 11.5 16 6.4 4.1 2.4 2 0 0 2 2 2 0 Cdc42 effector SET PF00856.23 CDI76600.1 - 2.4 8.4 6.2 1.8 8.8 0.8 2.2 2 0 0 2 2 2 0 SET domain Neuro_bHLH PF12533.3 CDI76600.1 - 2.5 8.9 29.2 1.6 9.5 7.2 2.2 2 0 0 2 2 2 0 Neuronal helix-loop-helix transcription factor Plasmodium_Vir PF05795.6 CDI76600.1 - 2.7 7.0 5.8 0.87 8.7 0.8 1.9 2 0 0 2 2 2 0 Plasmodium vivax Vir protein eIF_4EBP PF05456.6 CDI76600.1 - 2.8 7.6 15.3 7.1 6.3 1.2 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) IncA PF04156.9 CDI76600.1 - 2.8 7.5 32.7 2.5 7.6 9.0 2.3 2 0 0 2 2 2 0 IncA protein Mem_trans PF03547.13 CDI76600.1 - 2.9 6.1 7.5 3.7 5.7 2.7 2.0 2 0 0 2 2 2 0 Membrane transport protein PLRV_ORF5 PF01690.12 CDI76600.1 - 3.5 6.6 16.3 1.5 7.8 6.6 2.0 2 0 0 2 2 2 0 Potato leaf roll virus readthrough protein PAT1 PF09770.4 CDI76600.1 - 3.6 5.7 46.2 1.7 6.7 15.2 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PH_4 PF15404.1 CDI76600.1 - 5.8 6.3 16.9 0.52 9.8 0.5 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Gti1_Pac2 PF09729.4 CDI76600.1 - 6.1 6.6 12.6 10 5.9 4.3 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Pex16 PF08610.5 CDI76600.1 - 6.6 5.6 17.5 6.2 5.7 1.1 2.1 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) Peptidase_S49_N PF08496.5 CDI76600.1 - 6.7 6.4 17.0 8.7 6.1 2.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ctr PF04145.10 CDI76600.1 - 7.3 6.6 13.5 19 5.2 0.3 2.3 2 0 0 2 2 2 0 Ctr copper transporter family Apc15p PF05841.6 CDI76600.1 - 7.7 7.2 26.8 13 6.5 10.5 2.3 2 0 0 2 2 2 0 Apc15p protein FLO_LFY PF01698.11 CDI76600.1 - 8.1 5.1 16.5 0.74 8.5 4.7 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein DUF1510 PF07423.6 CDI76600.1 - 8.3 5.7 21.2 9.5 5.5 8.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Afi1 PF07792.7 CDI76600.1 - 9.6 6.2 17.3 3.1 7.7 5.4 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking HATPase_c PF02518.21 CDI76601.1 - 1.3e-14 53.8 0.0 6e-06 25.9 0.0 3.1 2 1 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CPSF100_C PF13299.1 CDI76601.1 - 0.014 15.5 2.2 0.024 14.8 1.5 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Hamartin PF04388.7 CDI76601.1 - 0.027 13.1 3.5 0.034 12.8 2.5 1.2 1 0 0 1 1 1 0 Hamartin protein FimP PF09766.4 CDI76601.1 - 0.044 12.8 10.8 0.23 10.4 8.5 1.4 2 0 0 2 2 2 0 Fms-interacting protein Suf PF05843.9 CDI76601.1 - 0.064 12.9 4.7 0.095 12.4 3.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) AIF_C PF14721.1 CDI76601.1 - 0.072 13.3 1.6 0.14 12.4 1.1 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SLD3 PF08639.5 CDI76601.1 - 0.31 9.6 10.0 0.49 8.9 7.0 1.2 1 0 0 1 1 1 0 DNA replication regulator SLD3 UPF0560 PF10577.4 CDI76601.1 - 0.73 8.0 11.9 1.1 7.4 8.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PAT1 PF09770.4 CDI76601.1 - 1.2 7.3 21.9 1.4 7.0 15.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.10 CDI76601.1 - 1.4 7.5 5.4 1.9 7.1 3.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) G0-G1_switch_2 PF15103.1 CDI76601.1 - 1.9 8.7 6.5 66 3.8 3.8 2.6 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF788 PF05620.6 CDI76601.1 - 2.3 8.0 7.8 13 5.5 5.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF788) DUF4557 PF15101.1 CDI76601.1 - 3.6 7.3 13.2 12 5.6 9.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Activator_LAG-3 PF11498.3 CDI76601.1 - 4.7 5.8 26.5 8.2 5.0 18.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Hid1 PF12722.2 CDI76601.1 - 5.4 4.5 8.3 7.2 4.1 5.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DivIC PF04977.10 CDI76601.1 - 6.9 6.2 12.0 11 5.5 8.3 1.3 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.9 CDI76601.1 - 8.5 5.9 16.2 13 5.2 11.2 1.2 1 0 0 1 1 1 0 IncA protein Btz PF09405.5 CDI76603.1 - 1.6e-10 41.1 11.7 1.6e-10 41.1 8.1 2.1 2 1 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding RRM_6 PF14259.1 CDI76604.1 - 0.0091 15.9 0.0 0.7 9.9 0.0 2.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-ribbon_3 PF13248.1 CDI76604.1 - 0.014 14.5 4.1 0.03 13.5 2.8 1.5 1 0 0 1 1 1 0 zinc-ribbon domain RRM_5 PF13893.1 CDI76604.1 - 0.057 13.2 0.0 1.8 8.4 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zinc_ribbon_2 PF13240.1 CDI76604.1 - 1.2 8.7 4.4 2.7 7.6 3.0 1.6 1 0 0 1 1 1 0 zinc-ribbon domain FimP PF09766.4 CDI76605.1 - 0.12 11.3 20.9 0.18 10.8 1.5 2.4 2 0 0 2 2 2 0 Fms-interacting protein Spt20 PF12090.3 CDI76605.1 - 0.15 11.3 13.0 0.45 9.8 0.8 2.3 2 0 0 2 2 2 0 Spt20 family zf-DHHC PF01529.15 CDI76605.1 - 1.3 8.3 3.5 21 4.4 0.0 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase PBP1_TM PF14812.1 CDI76605.1 - 7.4 6.9 8.6 43 4.5 0.5 3.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4613 PF15390.1 CDI76605.1 - 9.6 4.2 11.7 19 3.2 8.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) GMP_synt_C PF00958.17 CDI76609.1 - 2.3e-38 129.7 0.0 3.1e-38 129.3 0.0 1.2 1 0 0 1 1 1 1 GMP synthase C terminal domain RNA_pol_L PF01193.19 CDI76610.1 - 5.3e-09 35.0 0.0 6.4e-09 34.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.21 CDI76610.1 - 4.9e-07 29.8 0.0 7.8e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain DUF948 PF06103.6 CDI76611.1 - 3.8 7.4 4.8 39 4.1 0.2 3.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CD20 PF04103.10 CDI76613.1 - 0.81 9.6 7.3 0.2 11.6 0.5 3.1 3 1 0 3 3 3 0 CD20-like family Gly-zipper_OmpA PF13436.1 CDI76615.1 - 4.1 7.0 24.9 0.027 14.1 5.6 2.8 3 0 0 3 3 3 0 Glycine-zipper containing OmpA-like membrane domain Ribosomal_60s PF00428.14 CDI76615.1 - 6.4 7.2 44.3 1.1 9.7 9.4 4.3 2 1 1 3 3 3 0 60s Acidic ribosomal protein Nanovirus_C8 PF05629.6 CDI76617.1 - 0.16 11.7 0.2 0.17 11.6 0.1 1.1 1 0 0 1 1 1 0 Nanovirus component 8 (C8) protein SR-25 PF10500.4 CDI76618.1 - 0.0038 16.7 14.7 0.0038 16.7 10.2 5.3 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein APC_CDC26 PF10471.4 CDI76618.1 - 0.026 15.2 14.7 0.026 15.2 10.2 7.1 6 0 0 6 6 6 0 Anaphase-promoting complex APC subunit 1 AAA_23 PF13476.1 CDI76618.1 - 0.048 13.9 0.3 0.048 13.9 0.2 3.3 3 1 0 3 3 3 0 AAA domain Transformer PF06495.6 CDI76619.1 - 0.0088 15.9 3.5 0.018 14.9 2.5 1.4 1 0 0 1 1 1 1 Fruit fly transformer protein Suf PF05843.9 CDI76619.1 - 0.09 12.4 10.2 0.16 11.6 7.1 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4414 PF14377.1 CDI76619.1 - 6.7 6.6 16.9 22 5.0 11.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) Peptidase_S30 PF01577.11 CDI76619.1 - 8.5 5.6 9.8 14 4.9 6.8 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease EXS PF03124.9 CDI76623.1 - 5.6e-30 104.5 11.8 8e-18 64.5 2.5 2.3 2 0 0 2 2 2 2 EXS family SPX PF03105.14 CDI76623.1 - 2.4e-13 50.4 13.8 6.9e-13 49.0 9.6 1.6 1 1 0 1 1 1 1 SPX domain Polysacc_synt_2 PF02719.10 CDI76623.1 - 0.043 12.7 0.4 0.069 12.0 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Med15 PF09606.5 CDI76623.1 - 0.82 7.7 23.9 1.2 7.2 16.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal APC_CDC26 PF10471.4 CDI76623.1 - 1.2 9.8 23.7 0.11 13.2 3.3 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 Fringe PF02434.11 CDI76624.1 - 7e-20 71.2 0.4 4.2e-10 39.2 0.0 3.3 2 1 0 2 2 2 2 Fringe-like SR-25 PF10500.4 CDI76624.1 - 0.15 11.4 3.7 0.35 10.3 2.6 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF605 PF04652.11 CDI76625.1 - 3.3 6.9 42.8 0.92 8.8 8.9 3.6 3 0 0 3 3 3 0 Vta1 like LMF1 PF06762.9 CDI76626.1 - 1.5e-28 99.6 0.0 2e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Lipase maturation factor Cyt_c_ox_IV PF12270.3 CDI76626.1 - 0.003 17.3 0.9 0.0048 16.6 0.6 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DoxX PF07681.7 CDI76626.1 - 0.0039 17.5 3.2 0.0039 17.5 2.2 2.0 2 0 0 2 2 2 1 DoxX APC_CDC26 PF10471.4 CDI76626.1 - 0.045 14.4 10.0 0.15 12.8 1.2 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 DUF3609 PF12259.3 CDI76626.1 - 0.054 12.1 2.3 0.16 10.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3609) EphA2_TM PF14575.1 CDI76626.1 - 0.22 11.9 0.0 0.22 11.9 0.0 1.8 3 0 0 3 3 1 0 Ephrin type-A receptor 2 transmembrane domain Med15 PF09606.5 CDI76626.1 - 0.26 9.4 22.1 0.013 13.7 8.0 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal WBP-1 PF11669.3 CDI76626.1 - 1.1 9.3 4.8 8.8 6.4 0.0 3.0 3 0 0 3 3 3 0 WW domain-binding protein 1 YajC PF02699.10 CDI76626.1 - 2.9 7.6 9.7 0.23 11.1 2.1 2.1 2 0 0 2 2 2 0 Preprotein translocase subunit DUF3306 PF11748.3 CDI76626.1 - 6.4 7.4 9.7 0.47 11.1 2.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DivIC PF04977.10 CDI76626.1 - 7.5 6.1 10.3 0.87 9.1 3.6 1.9 2 0 0 2 2 2 0 Septum formation initiator SR-25 PF10500.4 CDI76627.1 - 0.014 14.9 7.4 0.02 14.3 5.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-RanBP PF00641.13 CDI76628.1 - 1.3e-06 27.4 5.2 1.3e-06 27.4 3.6 2.6 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others CAML PF14963.1 CDI76628.1 - 9.4 5.5 9.4 4.3 6.6 0.7 2.5 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Dynamin_M PF01031.15 CDI76629.1 - 3.2e-81 272.3 0.1 1.3e-80 270.3 0.0 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 CDI76629.1 - 5.8e-48 162.8 0.1 2.3e-47 160.9 0.0 2.1 3 0 0 3 3 3 1 Dynamin family GED PF02212.13 CDI76629.1 - 1.2e-14 53.9 0.0 4e-14 52.2 0.0 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CDI76629.1 - 0.0039 17.1 0.0 0.015 15.2 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDI76629.1 - 0.073 13.5 0.1 0.39 11.2 0.1 2.2 1 1 0 1 1 1 0 Miro-like protein Creb_binding PF09030.5 CDI76630.1 - 0.031 14.4 1.5 0.052 13.7 1.1 1.4 1 0 0 1 1 1 0 Creb binding PEN-2 PF10251.4 CDI76631.1 - 0.0057 16.8 0.1 0.021 15.0 0.0 1.9 1 1 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase CobD_Cbib PF03186.8 CDI76631.1 - 0.0063 15.6 0.5 0.014 14.4 0.1 1.6 1 1 0 1 1 1 1 CobD/Cbib protein PAT1 PF09770.4 CDI76631.1 - 2.8 6.0 55.1 3.3 5.8 38.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAGE_N PF12440.3 CDI76634.1 - 0.041 14.1 0.8 0.041 14.1 0.6 2.2 1 1 1 2 2 2 0 Melanoma associated antigen family N terminal IPK PF03770.11 CDI76635.1 - 7.5e-26 90.9 0.1 5.8e-15 55.4 0.0 3.8 3 2 0 3 3 3 2 Inositol polyphosphate kinase PAT1 PF09770.4 CDI76635.1 - 2.8 6.0 38.9 8.2 4.5 27.0 1.7 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TraT PF05818.7 CDI76637.1 - 3.9 6.8 9.8 7.3 5.9 0.6 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein Orai-1 PF07856.7 CDI76638.1 - 0.081 12.4 0.2 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Mediator of CRAC channel activity Ycf1 PF05758.7 CDI76639.1 - 2 6.0 14.2 3.2 5.3 9.8 1.3 1 0 0 1 1 1 0 Ycf1 SelR PF01641.13 CDI76640.1 - 7.1e-21 74.1 0.0 8.4e-21 73.9 0.0 1.0 1 0 0 1 1 1 1 SelR domain Pyr_redox_dim PF02852.17 CDI76642.1 - 2.1e-22 79.2 0.2 6.4e-15 55.1 0.1 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 CDI76642.1 - 9e-21 74.6 0.0 1.6e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI76642.1 - 5.2e-13 49.2 0.0 1.2e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDI76642.1 - 3.5e-06 27.2 0.0 9.4e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 CDI76642.1 - 0.0028 16.8 0.0 0.013 14.6 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.1 CDI76642.1 - 0.033 13.0 0.0 0.05 12.5 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.13 CDI76642.1 - 0.12 12.0 0.1 0.3 10.7 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DnaJ-X PF14308.1 CDI76644.1 - 2.3e-47 160.8 11.0 2.3e-47 160.8 7.6 3.0 3 1 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.26 CDI76644.1 - 1.7e-24 85.2 0.7 5.8e-24 83.5 0.5 2.0 1 0 0 1 1 1 1 DnaJ domain ATG_C PF09333.6 CDI76644.1 - 6.8e-08 32.5 0.1 8.6e-07 29.0 0.0 2.9 2 0 0 2 2 2 1 ATG C terminal domain DUF755 PF05501.6 CDI76644.1 - 0.0018 18.3 7.4 0.0018 18.3 5.1 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF755) Inhibitor_I71 PF12628.2 CDI76644.1 - 0.11 12.1 0.9 0.34 10.5 0.6 1.9 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor LUC7 PF03194.10 CDI76645.1 - 3.5e-54 184.0 13.1 5.9e-54 183.2 9.1 1.4 1 0 0 1 1 1 1 LUC7 N_terminus NPV_P10 PF05531.7 CDI76645.1 - 0.026 14.7 2.1 5.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein HSBP1 PF06825.7 CDI76645.1 - 0.26 10.8 0.1 0.26 10.8 0.1 2.4 3 0 0 3 3 3 0 Heat shock factor binding protein 1 HSCB_C PF07743.8 CDI76645.1 - 0.52 10.8 12.9 0.11 12.9 3.7 3.0 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain Mnd1 PF03962.10 CDI76645.1 - 0.62 9.6 17.9 0.082 12.5 2.9 2.2 2 0 0 2 2 2 0 Mnd1 family FliJ PF02050.11 CDI76645.1 - 1.6 8.7 23.2 1.2 9.2 6.5 3.4 2 1 1 3 3 3 0 Flagellar FliJ protein V_ATPase_I PF01496.14 CDI76645.1 - 4.9 4.8 9.5 0.26 9.1 2.2 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Syntaxin_2 PF14523.1 CDI76645.1 - 6 6.9 9.3 4 7.5 3.3 2.5 1 1 1 2 2 2 0 Syntaxin-like protein EMP24_GP25L PF01105.19 CDI76645.1 - 6.6 6.4 7.0 1.9e+02 1.6 4.8 2.6 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Cpn60_TCP1 PF00118.19 CDI76646.1 - 7.9e-140 466.6 1.3 9.1e-140 466.4 0.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3883 PF13020.1 CDI76647.1 - 3.3e-07 29.9 0.0 1.4e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3883) LAG1-DNAbind PF09271.6 CDI76647.1 - 1.5 9.3 10.9 0.33 11.4 0.2 3.8 4 0 0 4 4 4 0 LAG1, DNA binding LIN37 PF15306.1 CDI76647.1 - 2.7 7.9 19.8 0.027 14.4 1.1 3.2 3 1 0 3 3 3 0 LIN37 BT1 PF03092.11 CDI76648.1 - 1.8e-66 224.6 10.8 2.4e-66 224.2 7.5 1.0 1 0 0 1 1 1 1 BT1 family Med15 PF09606.5 CDI76649.1 - 0.00029 19.2 97.0 0.00029 19.2 67.2 9.1 4 2 4 9 9 9 3 ARC105 or Med15 subunit of Mediator complex non-fungal FimP PF09766.4 CDI76649.1 - 0.00035 19.7 6.7 0.00035 19.7 4.6 11.6 8 3 1 10 10 10 2 Fms-interacting protein Pex14_N PF04695.8 CDI76649.1 - 0.0024 17.9 2.9 0.0024 17.9 2.0 17.4 10 6 4 14 14 14 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Dehydrin PF00257.14 CDI76649.1 - 0.0041 17.4 0.9 0.0041 17.4 0.6 15.7 9 5 2 12 12 12 3 Dehydrin MCM_N PF14551.1 CDI76651.1 - 6.8e-09 36.2 0.0 1.2e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 MCM N-terminal domain IncA PF04156.9 CDI76651.1 - 1.5 8.3 12.2 2.6 7.5 8.5 1.4 1 0 0 1 1 1 0 IncA protein RskA PF10099.4 CDI76651.1 - 3 7.5 8.1 0.46 10.2 1.5 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF89 PF01937.14 CDI76653.1 - 2.7e-27 95.4 0.0 1.9e-26 92.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function DUF89 AIF_C PF14721.1 CDI76653.1 - 0.097 12.9 1.3 4.7 7.4 1.5 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Suf PF05843.9 CDI76653.1 - 0.39 10.4 3.8 0.52 9.9 2.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FimP PF09766.4 CDI76653.1 - 0.57 9.1 8.6 0.91 8.5 5.9 1.2 1 0 0 1 1 1 0 Fms-interacting protein CDK2AP PF09806.4 CDI76653.1 - 0.85 9.8 10.6 0.081 13.1 3.6 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein BaxI_1 PF12811.2 CDI76653.1 - 5.3 6.1 6.1 8 5.5 4.2 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like Histone PF00125.19 CDI76659.1 - 9.3e-26 89.7 0.0 1.2e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDI76659.1 - 7.4e-05 22.7 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CDI76660.1 - 8.8e-34 115.4 0.3 1.4e-33 114.8 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 CDI76660.1 - 0.00025 21.1 0.0 0.00037 20.6 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 CDI76660.1 - 0.0046 16.9 0.0 0.0097 15.9 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 CDI76660.1 - 0.1 12.3 0.1 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit TUSC2 PF15000.1 CDI76661.1 - 2.9e-05 24.0 0.0 2.9e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Tumour suppressor candidate 2 Androgen_recep PF02166.11 CDI76661.1 - 0.14 10.9 4.8 0.14 11.0 3.4 1.1 1 0 0 1 1 1 0 Androgen receptor TSA PF03249.8 CDI76661.1 - 7.3 5.0 7.9 7.5 4.9 5.5 1.0 1 0 0 1 1 1 0 Type specific antigen Pyr_redox_2 PF07992.9 CDI76662.1 - 1.2e-19 71.0 0.0 7.3e-19 68.4 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI76662.1 - 2.5e-07 31.0 0.0 0.00012 22.4 0.1 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDI76662.1 - 1.2e-05 25.5 0.0 0.0017 18.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 CDI76662.1 - 0.01 16.1 0.0 0.36 11.0 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.1 CDI76662.1 - 0.039 13.7 0.1 9.9 5.9 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding MAM33 PF02330.11 CDI76663.1 - 3.3e-05 23.7 2.2 3.3e-05 23.7 1.5 2.0 2 1 0 2 2 2 1 Mitochondrial glycoprotein Glyco_hydro_77 PF02446.12 CDI76663.1 - 0.0067 15.0 1.7 0.0078 14.8 1.2 1.0 1 0 0 1 1 1 1 4-alpha-glucanotransferase YceG PF02618.11 CDI76663.1 - 0.0071 15.4 1.2 0.0097 14.9 0.9 1.2 1 0 0 1 1 1 1 YceG-like family DUF2802 PF10975.3 CDI76663.1 - 0.018 14.8 8.6 0.032 13.9 5.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) YtkA PF13115.1 CDI76663.1 - 0.12 12.7 0.2 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 YtkA-like DUF3670 PF12419.3 CDI76663.1 - 0.14 11.5 0.0 0.14 11.5 0.0 2.1 3 0 0 3 3 3 0 SNF2 Helicase protein SpoVR PF04293.8 CDI76663.1 - 0.34 9.2 6.8 0.44 8.8 4.7 1.1 1 0 0 1 1 1 0 SpoVR like protein RskA PF10099.4 CDI76663.1 - 3.2 7.4 7.6 1.2 8.8 1.9 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA NUDIX PF00293.23 CDI76664.1 - 5.1e-10 39.1 0.0 6.8e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Ribosomal_60s PF00428.14 CDI76664.1 - 0.59 10.5 16.0 0.99 9.8 5.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein SAGA-Tad1 PF12767.2 CDI76664.1 - 0.68 9.5 13.7 0.83 9.2 9.5 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Adeno_PIX PF03955.9 CDI76664.1 - 1.6 9.3 9.1 6.9 7.2 3.3 2.3 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Suf PF05843.9 CDI76664.1 - 2.8 7.6 12.3 3.3 7.3 8.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pkinase PF00069.20 CDI76672.1 - 1.6e-24 86.4 0.1 1.2e-20 73.7 0.0 4.5 4 1 1 5 5 5 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76672.1 - 2.5e-11 43.1 0.1 5.8e-07 28.8 0.0 3.3 2 1 0 2 2 2 2 Protein tyrosine kinase Ribosomal_60s PF00428.14 CDI76673.1 - 0.0017 18.6 11.0 0.0017 18.6 7.6 8.0 6 2 1 7 7 7 3 60s Acidic ribosomal protein Mcp5_PH PF12814.2 CDI76673.1 - 0.09 12.6 0.0 9.4 6.1 0.0 2.5 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology Na_K-ATPase PF00287.13 CDI76675.1 - 0.18 10.5 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain PRA1 PF03208.14 CDI76675.1 - 0.18 11.1 2.9 0.25 10.6 2.0 1.2 1 0 0 1 1 1 0 PRA1 family protein WD40 PF00400.27 CDI76676.1 - 8.8e-18 63.4 5.7 0.00021 21.0 0.1 5.7 4 0 0 4 4 4 4 WD domain, G-beta repeat Peptidase_M20 PF01546.23 CDI76676.1 - 8.2e-11 41.7 0.3 0.00017 21.1 0.1 3.9 2 2 0 2 2 2 2 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDI76676.1 - 3.7e-05 23.4 0.0 0.00011 21.9 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain CKS PF01111.14 CDI76677.1 - 2.2e-17 62.6 0.0 4.6e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit CLAMP PF14769.1 CDI76677.1 - 0.13 12.3 1.7 0.2 11.8 0.1 2.0 2 0 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 DUF4611 PF15387.1 CDI76677.1 - 3.8 7.7 7.8 2.6 8.2 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) HR1 PF02185.11 CDI76680.1 - 3.5 7.4 11.3 0.1 12.3 1.5 2.8 3 1 0 3 3 3 0 Hr1 repeat A_deaminase PF00962.17 CDI76682.1 - 5.3e-48 163.6 0.0 5.8e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase SR-25 PF10500.4 CDI76684.1 - 0.00018 21.0 6.3 0.00018 21.0 4.4 9.3 9 1 1 10 10 10 2 Nuclear RNA-splicing-associated protein tRNA-synt_2c PF01411.14 CDI76688.1 - 1.5e-184 614.3 0.0 1e-183 611.5 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 CDI76688.1 - 9.7e-17 60.5 0.0 2.2e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 CDI76688.1 - 0.0058 16.3 1.9 0.0065 16.1 0.1 2.0 2 0 0 2 2 2 1 DHHA1 domain RRM_1 PF00076.17 CDI76689.1 - 1.3e-28 98.4 0.2 4.2e-16 58.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76689.1 - 6.7e-24 83.6 0.1 9.8e-13 47.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76689.1 - 7.2e-05 22.5 0.0 0.00031 20.5 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDI76689.1 - 0.078 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Dynamin_N PF00350.18 CDI76691.1 - 0.11 12.3 0.0 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 Dynamin family Miro PF08477.8 CDI76691.1 - 0.13 12.7 0.0 0.6 10.6 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein MMR_HSR1 PF01926.18 CDI76691.1 - 0.18 11.7 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Joubert PF15392.1 CDI76692.1 - 0.0027 17.0 0.3 0.0043 16.3 0.2 1.3 1 0 0 1 1 1 1 Joubert syndrome-associated BSD PF03909.12 CDI76692.1 - 0.038 13.7 0.1 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 BSD domain WD40 PF00400.27 CDI76696.1 - 1.1e-07 31.4 3.5 0.012 15.4 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Rad51 PF08423.6 CDI76698.1 - 9.2e-21 73.9 0.1 2e-20 72.7 0.0 1.6 1 1 1 2 2 2 1 Rad51 HHH_5 PF14520.1 CDI76698.1 - 0.094 12.8 0.2 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_6 PF14579.1 CDI76698.1 - 0.14 12.2 0.0 0.28 11.2 0.0 1.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif DEK_C PF08766.6 CDI76699.1 - 0.00058 19.5 2.5 0.001 18.7 1.7 1.4 1 0 0 1 1 1 1 DEK C terminal domain KGK PF08872.5 CDI76699.1 - 0.036 14.2 2.1 0.088 12.9 0.1 2.4 2 1 0 2 2 2 0 KGK domain Nop25 PF09805.4 CDI76699.1 - 0.051 13.6 10.5 0.071 13.1 7.3 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Fib_alpha PF08702.5 CDI76699.1 - 0.1 12.7 1.6 0.14 12.3 1.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RP-C_C PF11800.3 CDI76699.1 - 0.29 10.7 3.7 0.38 10.4 2.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Nop53 PF07767.6 CDI76699.1 - 0.3 10.0 15.4 0.38 9.7 10.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF342 PF03961.8 CDI76699.1 - 0.41 9.0 5.6 0.49 8.7 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) BTV_NS2 PF04514.7 CDI76699.1 - 0.74 8.6 7.7 0.84 8.4 5.4 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Dicty_REP PF05086.7 CDI76699.1 - 2.4 5.8 7.7 3.1 5.4 5.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CDC45 PF02724.9 CDI76699.1 - 5.7 4.8 7.7 6.8 4.5 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.5 CDI76699.1 - 6.5 6.7 11.8 8.3 6.3 8.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AP2 PF00847.15 CDI76705.1 - 3.6e-09 36.6 1.2 3.6e-09 36.6 0.8 4.5 5 0 0 5 5 5 1 AP2 domain F-box-like PF12937.2 CDI76707.1 - 0.083 12.6 3.7 0.21 11.3 2.6 1.6 1 0 0 1 1 1 0 F-box-like DUF3597 PF12200.3 CDI76708.1 - 0.14 12.5 3.4 0.17 12.2 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DUF844 PF05815.6 CDI76708.1 - 0.29 9.9 2.6 0.29 9.9 1.8 1.0 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) FAP PF07174.6 CDI76708.1 - 0.7 9.1 12.3 0.79 8.9 8.5 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) AAA PF00004.24 CDI76710.1 - 2.4e-15 56.8 1.4 4.3e-15 56.0 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDI76710.1 - 0.006 17.3 0.0 0.014 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDI76710.1 - 0.0086 15.9 0.0 0.0086 15.9 0.0 4.7 5 2 0 5 5 5 1 AAA domain EB1 PF03271.12 CDI76712.1 - 2.7e-11 43.3 0.0 5.4e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 CDI76712.1 - 2e-05 24.5 0.5 3e-05 24.0 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain zf-CCCH PF00642.19 CDI76714.1 - 1.7e-10 40.3 20.9 0.00074 19.1 3.0 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_11 PF13414.1 CDI76718.1 - 4.8e-15 54.9 4.2 1.5e-13 50.1 2.1 2.4 1 1 0 2 2 2 1 TPR repeat U-box PF04564.10 CDI76718.1 - 8.4e-14 51.2 0.1 3.6e-13 49.2 0.0 2.1 2 0 0 2 2 2 1 U-box domain TPR_1 PF00515.23 CDI76718.1 - 6.9e-12 44.4 5.1 4.7e-05 22.8 0.3 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 CDI76718.1 - 2.7e-10 39.3 6.5 0.00029 20.5 0.6 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat Apc3 PF12895.2 CDI76718.1 - 8.3e-08 32.2 0.7 1.4e-07 31.5 0.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 CDI76718.1 - 8.4e-07 28.8 4.9 2.4e-05 24.1 0.5 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDI76718.1 - 6.3e-06 25.6 1.8 0.047 13.4 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDI76718.1 - 0.00016 22.2 12.4 0.00048 20.7 1.3 2.8 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDI76718.1 - 0.0015 18.3 2.6 0.0071 16.1 0.4 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDI76718.1 - 0.0031 17.7 1.2 0.0077 16.5 0.9 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI76718.1 - 0.0037 17.3 0.2 6.6 7.1 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat Mhr1 PF12829.2 CDI76718.1 - 0.071 12.9 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination TPR_14 PF13428.1 CDI76718.1 - 0.087 13.5 4.2 14 6.6 0.0 3.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 CDI76718.1 - 1.4 9.0 4.5 4.5 7.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ubiquitin PF00240.18 CDI76719.1 - 7.6e-35 118.1 0.4 1e-34 117.7 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.12 CDI76719.1 - 1.1e-30 104.9 10.6 1.8e-30 104.2 7.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.3 CDI76719.1 - 8e-21 73.5 0.5 1.2e-20 72.9 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDI76719.1 - 1.1e-06 28.8 0.1 3.5e-06 27.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CDI76719.1 - 0.00046 19.9 0.0 0.00071 19.2 0.0 1.3 1 0 0 1 1 1 1 Telomere stability and silencing TUG-UBL1 PF11470.3 CDI76719.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 GLUT4 regulating protein TUG Rad60-SLD_2 PF13881.1 CDI76719.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CDI76719.1 - 0.021 15.0 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Fer2_3 PF13085.1 CDI76719.1 - 0.23 11.3 1.9 1.4 8.7 1.0 2.1 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Surface_antigen PF11054.3 CDI76720.1 - 8.1e-56 189.2 1.7 1e-55 188.8 1.1 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen FAD_binding_4 PF01565.18 CDI76721.1 - 5.3e-33 113.4 0.2 9e-33 112.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.14 CDI76721.1 - 3.3e-31 108.5 0.0 1.6e-23 83.3 0.0 2.1 2 0 0 2 2 2 2 FAD linked oxidases, C-terminal domain PARG_cat PF05028.9 CDI76722.1 - 2.1e-05 23.9 0.0 8.7e-05 21.9 0.0 1.9 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) SNARE_assoc PF09335.6 CDI76723.1 - 5.1e-16 58.9 6.6 5.1e-16 58.9 4.6 2.7 3 0 0 3 3 3 1 SNARE associated Golgi protein YqhR PF11085.3 CDI76723.1 - 0.35 10.3 1.9 0.65 9.5 0.1 2.2 2 0 0 2 2 2 0 Conserved membrane protein YqhR DUF2842 PF11003.3 CDI76723.1 - 1.5 8.7 8.5 0.71 9.7 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2842) EMG1 PF03587.9 CDI76724.1 - 6e-60 202.0 0.1 7.2e-60 201.7 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase MIP-T3 PF10243.4 CDI76725.1 - 0.93 7.8 43.8 1.1 7.6 30.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Asp-B-Hydro_N PF05279.6 CDI76725.1 - 2.2 8.0 40.3 2.9 7.6 27.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF966 PF06136.8 CDI76725.1 - 2.6 7.3 19.0 3.7 6.8 13.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CRAL_TRIO PF00650.15 CDI76726.1 - 5e-06 26.0 0.0 8.5e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain STAS PF01740.16 CDI76726.1 - 0.15 11.4 0.0 0.41 10.0 0.0 1.7 2 0 0 2 2 2 0 STAS domain CcoS PF03597.10 CDI76727.1 - 0.012 14.9 0.3 0.028 13.8 0.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type SIT PF15330.1 CDI76727.1 - 0.13 12.4 1.0 0.42 10.7 0.7 1.9 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT MLANA PF14991.1 CDI76727.1 - 0.42 10.6 1.6 2.8 7.9 0.4 2.5 3 0 0 3 3 3 0 Protein melan-A zf-RING_2 PF13639.1 CDI76728.1 - 4.2e-10 39.2 12.8 4.2e-10 39.2 8.9 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CDI76728.1 - 2.1e-06 27.7 6.5 2.1e-06 27.7 4.5 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 CDI76728.1 - 1.4e-05 25.0 7.1 1.4e-05 25.0 4.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDI76728.1 - 0.00062 19.3 8.5 0.00062 19.3 5.9 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI76728.1 - 0.0011 18.5 7.1 0.0011 18.5 4.9 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDI76728.1 - 0.0029 17.2 1.7 0.0075 15.9 1.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 CDI76728.1 - 0.0049 16.5 10.0 0.0049 16.5 6.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 CDI76728.1 - 0.075 12.8 5.3 0.16 11.8 3.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CDI76728.1 - 8.5 6.0 9.0 23 4.6 6.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PARG_cat PF05028.9 CDI76729.1 - 2.6e-65 220.9 0.0 7e-56 189.9 0.0 2.0 2 0 0 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) Radial_spoke_3 PF06098.6 CDI76731.1 - 4.6e-06 25.8 9.0 7.2e-06 25.2 6.3 1.2 1 0 0 1 1 1 1 Radial spoke protein 3 KOG2701 PF09762.4 CDI76731.1 - 0.02 14.9 0.7 0.035 14.1 0.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) TRM13 PF05206.9 CDI76733.1 - 3.7e-21 75.5 0.0 1.8e-13 50.3 0.0 4.8 4 1 0 4 4 4 2 Methyltransferase TRM13 zf-U11-48K PF05253.7 CDI76733.1 - 2.7e-06 26.9 0.3 4.9e-06 26.1 0.2 1.5 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger DUF775 PF05603.7 CDI76733.1 - 0.42 10.0 2.7 0.96 8.9 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Vac14_Fig4_bd PF11916.3 CDI76734.1 - 1.7e-36 125.1 3.1 1.1e-31 109.3 1.3 2.5 2 0 0 2 2 2 2 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 CDI76734.1 - 6.6e-13 48.8 0.1 1.3e-11 44.7 0.0 3.0 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.17 CDI76734.1 - 0.002 18.0 0.0 2.9 8.2 0.0 4.3 3 0 0 3 3 3 1 HEAT repeat PPR_2 PF13041.1 CDI76735.1 - 4.5e-10 39.3 0.1 2.1e-05 24.4 0.0 4.7 4 1 1 5 5 5 2 PPR repeat family PPR PF01535.15 CDI76735.1 - 8.3e-10 37.9 6.1 0.016 15.1 0.1 6.4 7 0 0 7 7 7 2 PPR repeat PPR_3 PF13812.1 CDI76735.1 - 4.9e-08 32.6 29.1 0.34 11.2 0.0 10.2 10 1 0 10 10 10 3 Pentatricopeptide repeat domain Imm16 PF15565.1 CDI76735.1 - 0.011 15.5 0.3 0.059 13.2 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 16 TPR_3 PF07720.7 CDI76735.1 - 0.041 13.7 1.2 0.21 11.4 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI76735.1 - 7.6 6.6 11.6 0.34 10.8 0.2 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat zf-met PF12874.2 CDI76736.1 - 6.1e-07 29.4 1.5 1.2e-06 28.5 1.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.4 CDI76736.1 - 0.046 13.3 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein Glyoxalase PF00903.20 CDI76737.1 - 1.2e-10 41.4 0.0 3.3e-08 33.5 0.0 2.9 3 0 0 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CDI76737.1 - 4.7e-10 40.0 0.0 5.7e-07 30.1 0.0 3.4 3 1 0 3 3 3 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 CDI76737.1 - 0.00052 20.0 0.1 0.043 13.8 0.0 2.5 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 CDI76737.1 - 0.089 12.6 0.1 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Glyoxalase-like domain PAT1 PF09770.4 CDI76742.1 - 0.9 7.7 50.2 1.2 7.3 34.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.7 CDI76742.1 - 4 5.9 18.9 5.3 5.5 13.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FtsJ PF01728.14 CDI76744.1 - 2.2e-17 63.6 0.0 7.3e-17 61.9 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltrans_Mon PF14314.1 CDI76744.1 - 0.068 11.0 0.0 0.12 10.2 0.0 1.2 1 0 0 1 1 1 0 Virus-capping methyltransferase Mito_carr PF00153.22 CDI76745.1 - 1e-57 191.8 4.0 7.6e-22 76.8 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein AAA PF00004.24 CDI76746.1 - 4.7e-05 23.6 0.0 0.00012 22.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 CDI76746.1 - 0.028 14.0 0.1 0.065 12.8 0.1 1.5 1 0 0 1 1 1 0 NACHT domain CDC50 PF03381.10 CDI76747.1 - 1.5e-16 60.4 0.0 2.9e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family PAT1 PF09770.4 CDI76748.1 - 0.0031 15.8 62.8 0.0034 15.7 43.5 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI76748.1 - 0.0032 15.7 81.1 0.0035 15.6 56.2 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4175 PF13779.1 CDI76748.1 - 0.026 12.2 61.0 0.033 11.8 42.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Caldesmon PF02029.10 CDI76748.1 - 0.16 10.3 23.9 0.19 10.1 16.6 1.1 1 0 0 1 1 1 0 Caldesmon GAGA_bind PF06217.7 CDI76748.1 - 1.2 9.0 28.7 1.5 8.7 19.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4045 PF13254.1 CDI76748.1 - 1.3 8.2 24.3 1.7 7.8 16.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AvrE PF11725.3 CDI76748.1 - 2.6 4.9 31.0 2.9 4.8 21.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor DUF1675 PF07897.6 CDI76748.1 - 3.4 7.4 25.2 4.2 7.1 17.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Macoilin PF09726.4 CDI76748.1 - 3.5 5.7 27.8 4.8 5.3 19.2 1.1 1 0 0 1 1 1 0 Transmembrane protein TFIIA PF03153.8 CDI76748.1 - 6.5 6.5 49.4 9.6 5.9 34.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.4 CDI76753.1 - 4.5 6.6 8.4 6.2 6.2 5.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PIP5K PF01504.13 CDI76756.1 - 4.4e-35 121.0 0.1 6.7e-35 120.3 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.27 CDI76756.1 - 0.00019 20.4 1.7 0.00033 19.7 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 CDI76756.1 - 0.0025 17.9 0.1 0.0078 16.3 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 CDI76756.1 - 0.0054 16.5 0.1 0.05 13.5 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 CDI76756.1 - 0.053 13.1 0.6 0.15 11.6 0.4 1.8 1 0 0 1 1 1 0 EF-hand domain pair DUF1319 PF07028.6 CDI76756.1 - 0.074 13.2 2.7 0.14 12.3 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) GvpK PF05121.7 CDI76756.1 - 0.18 11.6 2.9 0.45 10.3 2.0 1.6 1 0 0 1 1 1 0 Gas vesicle protein K RRM_1 PF00076.17 CDI76757.1 - 6.3e-37 125.0 0.2 3.8e-14 52.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76757.1 - 1.5e-26 92.1 0.2 7.8e-10 38.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76757.1 - 1.9e-25 88.4 0.0 1.4e-07 31.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CDI76757.1 - 0.0097 15.7 0.5 3.2 7.6 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif AAA_11 PF13086.1 CDI76759.1 - 6e-67 225.6 0.3 1.1e-65 221.5 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_12 PF13087.1 CDI76759.1 - 1.9e-36 125.3 0.0 3.2e-20 72.3 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.1 CDI76759.1 - 8.6e-10 38.2 0.1 8.5e-06 25.4 0.1 2.9 2 0 0 2 2 2 2 Part of AAA domain AAA_30 PF13604.1 CDI76759.1 - 8e-08 32.0 0.3 0.002 17.7 0.1 2.9 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 CDI76759.1 - 0.001 18.6 0.1 0.033 13.7 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 CDI76759.1 - 0.013 14.8 0.2 2.1 7.5 0.0 3.1 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Dioxygenase_N PF04444.9 CDI76759.1 - 0.026 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus AAA PF00004.24 CDI76759.1 - 0.17 12.0 0.1 0.41 10.8 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PNTB PF02233.11 CDI76761.1 - 2.3e-202 672.8 20.6 2.3e-202 672.8 14.3 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 CDI76761.1 - 2.6e-48 163.7 0.4 5e-48 162.8 0.3 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 CDI76761.1 - 1.5e-32 112.4 0.1 3.3e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain DUF3814 PF12769.2 CDI76761.1 - 3.6e-22 78.3 5.8 3.6e-22 78.3 4.0 4.5 3 2 2 5 5 5 1 Domain of unknown function (DUF3814) 2-Hacid_dh_C PF02826.14 CDI76761.1 - 4.1e-06 26.0 0.4 0.093 11.8 0.0 2.4 1 1 1 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.17 CDI76761.1 - 0.00025 20.7 0.1 0.0014 18.3 0.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Shikimate_DH PF01488.15 CDI76761.1 - 0.0098 15.9 1.0 6.4 6.8 0.3 2.8 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase Methyltransf_31 PF13847.1 CDI76761.1 - 0.035 13.6 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pyr_redox_2 PF07992.9 CDI76761.1 - 0.068 13.0 0.5 0.15 11.9 0.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ABC_membrane PF00664.18 CDI76762.1 - 1.5 8.1 0.0 2.7 7.3 0.0 1.3 1 0 0 1 1 1 0 ABC transporter transmembrane region SNF2_N PF00176.18 CDI76763.1 - 3.2e-50 170.6 1.4 5e-40 137.1 0.8 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 CDI76763.1 - 2e-12 46.7 0.0 2e-12 46.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDI76763.1 - 5.8e-05 22.6 0.0 5.8e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Nop25 PF09805.4 CDI76763.1 - 0.0052 16.8 12.2 0.0052 16.8 8.5 2.6 3 0 0 3 3 3 1 Nucleolar protein 12 (25kDa) BAF1_ABF1 PF04684.8 CDI76763.1 - 0.035 12.9 7.9 0.068 12.0 5.5 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Peptidase_U57 PF05582.7 CDI76763.1 - 1.1 8.1 6.0 1.9 7.4 4.1 1.3 1 0 0 1 1 1 0 YabG peptidase U57 Serinc PF03348.10 CDI76763.1 - 2.1 6.9 5.7 4.3 5.9 3.9 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) RRM_1 PF00076.17 CDI76767.1 - 0.0014 18.2 0.0 0.003 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_E2-like PF04497.7 CDI76767.1 - 1.5 6.7 4.0 2.5 6.0 2.8 1.3 1 0 0 1 1 1 0 Poxviridae protein p25-alpha PF05517.7 CDI76768.1 - 0.003 17.8 0.2 0.003 17.8 0.1 2.0 2 0 0 2 2 2 1 p25-alpha TMEM171 PF15471.1 CDI76768.1 - 0.59 8.8 4.1 0.45 9.2 0.2 2.1 2 0 0 2 2 2 0 Transmembrane protein family 171 SAPS PF04499.10 CDI76768.1 - 0.67 8.5 5.7 1.1 7.8 3.9 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BSMAP PF12280.3 CDI76768.1 - 0.8 9.5 7.1 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Brain specific membrane anchored protein Neur_chan_memb PF02932.11 CDI76768.1 - 3.1 7.6 4.6 7.7 6.3 3.2 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Herpes_DNAp_acc PF04929.7 CDI76768.1 - 3.1 6.6 9.9 1.9 7.3 1.0 2.3 2 0 0 2 2 2 0 Herpes DNA replication accessory factor Med3 PF11593.3 CDI76768.1 - 4.3 6.4 13.1 8.5 5.5 9.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DDHD PF02862.12 CDI76768.1 - 7.7 6.2 11.6 5.5 6.7 0.5 2.2 2 0 0 2 2 2 0 DDHD domain Peptidase_S49_N PF08496.5 CDI76768.1 - 9.2 6.0 10.5 15 5.3 1.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal MIP-T3 PF10243.4 CDI76769.1 - 9.4 4.5 86.1 2.4 6.5 21.3 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 Herpes_UL32 PF06070.6 CDI76770.1 - 0.34 9.3 5.2 0.37 9.2 3.6 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 FHA PF00498.21 CDI76771.1 - 0.015 15.3 0.1 0.026 14.6 0.1 1.3 1 0 0 1 1 1 0 FHA domain Ribosomal_60s PF00428.14 CDI76771.1 - 0.027 14.8 11.1 0.027 14.8 7.7 4.3 3 1 0 3 3 3 0 60s Acidic ribosomal protein DUF3040 PF11239.3 CDI76771.1 - 0.1 12.6 1.3 0.21 11.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) RAB3GAP2_N PF14655.1 CDI76771.1 - 0.19 10.7 2.8 1.2 8.0 0.4 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus MRP-S31 PF15433.1 CDI76771.1 - 0.3 10.4 4.5 1.4 8.2 0.7 2.2 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 DUF1180 PF06679.7 CDI76771.1 - 1.3 8.8 14.7 2.9 7.7 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) UPF0560 PF10577.4 CDI76771.1 - 1.4 7.0 9.2 0.29 9.3 0.9 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 Lin-8 PF03353.10 CDI76771.1 - 3.1 7.0 5.8 3.8 6.7 0.3 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist RRM_6 PF14259.1 CDI76772.1 - 0.00011 22.1 0.0 0.00022 21.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76772.1 - 0.00056 19.7 0.0 0.00099 18.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI76772.1 - 0.0078 15.8 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2458 PF10454.4 CDI76773.1 - 0.059 13.2 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF4228 PF14009.1 CDI76773.1 - 0.11 12.6 0.7 0.22 11.6 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Ycf1 PF05758.7 CDI76775.1 - 0.00053 17.8 16.9 0.0034 15.1 3.6 2.5 2 0 0 2 2 2 2 Ycf1 SprA-related PF12118.3 CDI76775.1 - 0.0023 17.3 30.0 0.0023 17.3 20.8 11.2 8 5 1 9 9 9 1 SprA-related family Hid1 PF12722.2 CDI76775.1 - 9.4 3.7 38.0 0.016 12.9 6.5 3.7 3 0 0 3 3 3 0 High-temperature-induced dauer-formation protein Glycos_transf_1 PF00534.15 CDI76778.1 - 1.3e-08 34.4 0.9 6.4e-05 22.4 0.0 2.9 3 0 0 3 3 3 2 Glycosyl transferases group 1 Mem_trans PF03547.13 CDI76778.1 - 0.0023 16.3 0.6 0.2 9.8 0.0 2.2 2 0 0 2 2 2 2 Membrane transport protein SPX PF03105.14 CDI76778.1 - 0.0089 15.8 3.2 0.0089 15.8 2.2 3.2 3 0 0 3 3 3 2 SPX domain Ycf1 PF05758.7 CDI76778.1 - 1.4 6.5 18.6 0.023 12.4 1.0 2.4 3 0 0 3 3 3 0 Ycf1 eIF-3_zeta PF05091.7 CDI76778.1 - 6.5 5.2 32.8 0.022 13.4 2.7 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CBFD_NFYB_HMF PF00808.18 CDI76779.1 - 4.8e-06 26.5 0.0 1.1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CDI76779.1 - 0.03 14.4 0.2 0.11 12.6 0.2 2.0 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Pox_G5 PF04599.7 CDI76779.1 - 8.4 4.9 6.1 14 4.2 4.2 1.2 1 0 0 1 1 1 0 Poxvirus G5 protein Arm PF00514.18 CDI76780.1 - 4.1e-79 257.9 23.4 2.3e-14 52.5 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 CDI76780.1 - 5.4e-22 77.8 9.0 9.9e-07 28.9 0.0 5.9 2 1 3 6 6 6 5 HEAT repeats HEAT_EZ PF13513.1 CDI76780.1 - 1e-18 67.1 18.9 6.5e-07 29.6 0.0 6.4 5 4 3 8 8 8 4 HEAT-like repeat HEAT PF02985.17 CDI76780.1 - 2.5e-13 48.8 7.9 6e-05 22.7 0.0 7.5 8 0 0 8 8 8 3 HEAT repeat Arm_2 PF04826.8 CDI76780.1 - 0.0001 21.4 0.0 0.16 11.0 0.0 2.3 1 1 1 2 2 2 2 Armadillo-like V-ATPase_H_C PF11698.3 CDI76780.1 - 0.00063 19.6 0.0 13 5.7 0.0 3.5 2 1 0 3 3 3 1 V-ATPase subunit H Adaptin_N PF01602.15 CDI76780.1 - 0.0017 16.7 0.0 0.28 9.4 0.0 3.2 1 1 1 2 2 2 2 Adaptin N terminal region HEAT_PBS PF03130.11 CDI76780.1 - 0.0048 17.2 7.6 0.35 11.4 0.0 6.2 8 0 0 8 8 8 1 PBS lyase HEAT-like repeat RuvA_C PF07499.8 CDI76780.1 - 0.03 14.5 0.4 0.28 11.3 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain Mo25 PF08569.6 CDI76780.1 - 0.099 11.6 0.0 0.38 9.7 0.0 1.9 1 1 1 2 2 2 0 Mo25-like SOBP PF15279.1 CDI76781.1 - 0.0017 18.8 29.3 0.0018 18.7 20.3 1.1 1 0 0 1 1 1 1 Sine oculis-binding protein DUF605 PF04652.11 CDI76781.1 - 0.015 14.7 40.7 0.021 14.2 28.2 1.2 1 0 0 1 1 1 0 Vta1 like CAF-1_p150 PF11600.3 CDI76781.1 - 0.023 14.0 43.6 0.034 13.5 30.2 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Med15 PF09606.5 CDI76781.1 - 0.25 9.5 86.8 0.33 9.1 60.2 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI76781.1 - 0.31 9.2 64.7 0.41 8.8 44.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI76781.1 - 0.78 9.5 58.8 0.96 9.2 40.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YjgP_YjgQ PF03739.9 CDI76781.1 - 1.1 7.9 16.2 1.6 7.3 11.3 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Spc7_N PF15402.1 CDI76781.1 - 1.5 6.7 38.6 2.4 6.0 26.8 1.3 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Utp14 PF04615.8 CDI76781.1 - 1.6 6.7 43.6 2 6.5 30.2 1.0 1 0 0 1 1 1 0 Utp14 protein Shadoo PF14999.1 CDI76781.1 - 1.8 8.4 9.0 2.1 8.1 5.8 1.4 1 1 0 1 1 1 0 Shadow of prion protein, neuroprotective Nop53 PF07767.6 CDI76781.1 - 1.9 7.4 44.0 2.7 6.8 30.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RR_TM4-6 PF06459.7 CDI76781.1 - 2.2 8.1 29.3 3 7.6 20.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Dicty_REP PF05086.7 CDI76781.1 - 4 5.0 27.3 5.3 4.6 18.9 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Parvo_coat PF00740.13 CDI76781.1 - 9.8 4.9 39.6 12 4.6 27.4 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Spt20 PF12090.3 CDI76782.1 - 0.14 11.5 5.1 2.6 7.3 0.4 2.8 3 0 0 3 3 3 0 Spt20 family DUF2722 PF10846.3 CDI76782.1 - 0.17 10.8 9.1 1.1 8.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Med15 PF09606.5 CDI76782.1 - 0.72 7.9 33.4 0.13 10.4 5.4 3.1 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal RCC1 PF00415.13 CDI76785.1 - 2.4e-22 78.8 5.9 3.6e-13 49.4 0.3 3.6 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI76785.1 - 8.2e-11 41.2 18.7 2.2e-05 23.9 4.9 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat PID PF00640.18 CDI76787.1 - 0.16 11.9 2.0 0.35 10.8 1.4 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF3520 PF12034.3 CDI76787.1 - 0.26 11.4 4.9 0.39 10.8 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3520) DNA_ligase_A_N PF04675.9 CDI76787.1 - 0.33 10.7 3.3 0.47 10.2 2.3 1.2 1 0 0 1 1 1 0 DNA ligase N terminus NTP_transf_5 PF14907.1 CDI76787.1 - 0.77 9.0 5.6 1 8.6 3.9 1.1 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase APG6 PF04111.7 CDI76787.1 - 1.3 7.9 6.7 1.7 7.5 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2570 PF10828.3 CDI76787.1 - 6.4 6.4 11.7 9.2 5.9 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) FUSC PF04632.7 CDI76787.1 - 6.7 5.0 15.6 12 4.2 10.8 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family DivIC PF04977.10 CDI76787.1 - 7 6.2 8.9 2.3 7.7 4.1 1.8 1 1 1 2 2 2 0 Septum formation initiator SNF2_N PF00176.18 CDI76791.1 - 1.2e-33 116.1 4.9 2.4e-29 102.0 0.0 3.0 3 0 0 3 3 3 2 SNF2 family N-terminal domain zf-RING_2 PF13639.1 CDI76791.1 - 3.3e-07 30.0 9.3 3.3e-07 30.0 6.4 3.8 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDI76791.1 - 2.7e-05 24.0 7.3 2.7e-05 24.0 5.0 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDI76791.1 - 0.00025 20.6 9.2 0.0013 18.3 6.4 2.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CDI76791.1 - 0.00064 19.5 5.6 0.00064 19.5 3.9 3.6 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING DBR1 PF05011.8 CDI76794.1 - 1.6e-07 31.3 0.0 2.5e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain DUF3045 PF11243.3 CDI76794.1 - 0.16 12.1 0.1 0.67 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3045) EF1_GNE PF00736.14 CDI76795.1 - 3.5e-28 97.1 3.1 3.5e-28 97.1 2.2 1.8 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain DUF2122 PF09895.4 CDI76795.1 - 0.24 11.5 4.1 3.3 7.9 0.1 2.3 2 0 0 2 2 2 0 RecB-family nuclease (DUF2122) MCM_bind PF09739.4 CDI76796.1 - 1.9e-10 40.3 0.4 1.9e-10 40.3 0.3 3.0 3 1 0 3 3 3 1 Mini-chromosome maintenance replisome factor Racemase_4 PF13615.1 CDI76796.1 - 2e-05 24.7 0.1 0.011 15.9 0.0 2.5 2 0 0 2 2 2 2 Putative alanine racemase Herpes_UL87 PF03043.9 CDI76796.1 - 0.05 12.0 3.9 0.077 11.3 2.7 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family RAB3GAP2_N PF14655.1 CDI76796.1 - 0.94 8.4 22.7 0.074 12.0 0.6 3.2 1 1 2 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF247 PF03140.10 CDI76796.1 - 1.3 7.9 11.8 5.3 5.9 0.1 2.4 1 1 1 2 2 2 0 Plant protein of unknown function Suf PF05843.9 CDI76796.1 - 2.6 7.7 14.4 3.4 7.3 0.2 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Med15 PF09606.5 CDI76796.1 - 5.4 5.0 44.6 3 5.9 16.9 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF572 PF04502.8 CDI76796.1 - 6.3 5.9 17.6 17 4.4 12.2 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF572) NTF2 PF02136.15 CDI76797.1 - 2e-29 102.3 0.0 2.2e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.4 CDI76797.1 - 0.00079 19.2 0.0 0.00083 19.1 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 SnoaL_2 PF12680.2 CDI76797.1 - 0.14 12.5 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain Fumble PF03630.9 CDI76800.1 - 1.5e-47 162.1 0.0 6.2e-33 114.0 0.0 2.3 1 1 1 2 2 2 2 Fumble Pkinase PF00069.20 CDI76801.1 - 9e-10 38.1 0.0 1.2e-05 24.6 0.0 3.7 4 0 0 4 4 4 2 Protein kinase domain Med15 PF09606.5 CDI76803.1 - 0.018 13.2 47.3 0.022 13.0 32.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_11 PF13086.1 CDI76803.1 - 0.046 13.2 11.0 0.074 12.6 7.7 1.5 1 0 0 1 1 1 0 AAA domain Hid1 PF12722.2 CDI76803.1 - 1 6.9 22.9 1.3 6.6 15.8 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0560 PF10577.4 CDI76803.1 - 2.7 6.1 22.0 4.3 5.4 15.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PCEMA1 PF07418.6 CDI76803.1 - 4.2 6.6 19.2 5.5 6.2 13.3 1.3 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 GPCR_chapero_1 PF11904.3 CDI76803.1 - 4.3 6.3 19.4 6.2 5.8 13.4 1.3 1 0 0 1 1 1 0 GPCR-chaperone Neur_chan_memb PF02932.11 CDI76803.1 - 5.4 6.8 16.5 1.9 8.3 9.5 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.17 CDI76803.1 - 7.7 5.4 10.9 2 7.3 5.6 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter WBS_methylT PF12589.3 CDI76804.1 - 1.1e-12 48.2 9.4 1.1e-12 48.2 6.5 2.3 2 0 0 2 2 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 CDI76804.1 - 2.6e-06 27.8 0.0 6.4e-05 23.3 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI76804.1 - 0.016 14.7 0.0 0.058 12.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain TPMT PF05724.6 CDI76804.1 - 0.037 13.4 0.0 0.083 12.3 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.1 CDI76804.1 - 0.089 13.1 0.1 0.52 10.7 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain Exonuc_VIII PF06630.6 CDI76804.1 - 0.099 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII TCP PF03634.8 CDI76804.1 - 0.32 11.3 6.9 0.05 13.9 1.2 2.0 2 0 0 2 2 2 0 TCP family transcription factor SR-25 PF10500.4 CDI76805.1 - 0.00042 19.8 9.9 0.00042 19.8 6.9 6.6 4 2 1 5 5 5 3 Nuclear RNA-splicing-associated protein ParA PF10609.4 CDI76806.1 - 9e-30 102.4 0.1 3.2e-29 100.6 0.1 1.9 1 1 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 CDI76806.1 - 8.5e-20 70.9 0.0 1.5e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CDI76806.1 - 7.8e-07 29.1 0.0 2.3e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain MipZ PF09140.6 CDI76806.1 - 1.2e-05 24.5 0.0 7.6e-05 21.9 0.0 2.3 2 1 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.10 CDI76806.1 - 0.00013 21.1 0.1 0.00013 21.1 0.1 3.0 3 1 1 4 4 4 1 Anion-transporting ATPase DUF258 PF03193.11 CDI76806.1 - 0.00045 19.4 0.1 0.0014 17.8 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 BAF1_ABF1 PF04684.8 CDI76806.1 - 0.00074 18.4 5.8 0.00074 18.4 4.1 2.2 2 0 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor YhjQ PF06564.7 CDI76806.1 - 0.0011 18.4 0.1 0.0011 18.4 0.1 2.3 2 1 0 2 2 2 1 YhjQ protein G-alpha PF00503.15 CDI76806.1 - 0.0011 17.7 1.7 0.0016 17.2 1.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit IncA PF04156.9 CDI76806.1 - 0.003 17.1 4.4 0.0068 16.0 3.0 1.5 1 0 0 1 1 1 1 IncA protein ArgK PF03308.11 CDI76806.1 - 0.0057 15.4 1.1 0.0086 14.8 0.0 1.7 2 0 0 2 2 2 1 ArgK protein DUF4094 PF13334.1 CDI76806.1 - 0.0079 16.5 0.3 0.0079 16.5 0.2 1.8 2 0 0 2 2 1 1 Domain of unknown function (DUF4094) NB-ARC PF00931.17 CDI76806.1 - 0.0099 14.7 0.1 0.0099 14.7 0.1 1.7 2 0 0 2 2 2 1 NB-ARC domain AAA_17 PF13207.1 CDI76806.1 - 0.016 16.0 0.0 0.027 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain EphA2_TM PF14575.1 CDI76806.1 - 0.017 15.5 0.3 0.034 14.5 0.2 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Oleosin PF01277.12 CDI76806.1 - 0.019 14.5 0.1 0.053 13.0 0.0 1.7 1 0 0 1 1 1 0 Oleosin APS_kinase PF01583.15 CDI76806.1 - 0.032 13.8 0.0 0.065 12.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_25 PF13481.1 CDI76806.1 - 0.043 13.2 0.0 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CDI76806.1 - 0.096 12.8 0.4 1.2 9.2 0.1 2.6 3 0 0 3 3 3 0 AAA domain Galanin PF01296.13 CDI76806.1 - 0.096 12.5 1.4 0.25 11.2 1.0 1.7 1 0 0 1 1 1 0 Galanin KTI12 PF08433.5 CDI76806.1 - 0.11 11.7 1.6 0.24 10.5 0.0 2.1 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_26 PF13500.1 CDI76806.1 - 0.12 11.9 4.0 0.52 9.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 CDI76806.1 - 0.16 11.4 1.1 0.95 9.0 0.3 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.1 CDI76806.1 - 0.18 12.1 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2489 PF10675.4 CDI76806.1 - 0.57 9.8 11.7 0.038 13.6 4.4 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF2489) RAB3GAP2_N PF14655.1 CDI76806.1 - 2 7.3 7.1 2.6 6.9 4.5 1.5 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TSP_1 PF00090.14 CDI76808.1 - 5.2e-07 29.6 6.6 5.2e-07 29.6 4.6 5.2 5 0 0 5 5 5 3 Thrombospondin type 1 domain Secretin_N_2 PF07655.8 CDI76808.1 - 6.4 7.2 11.0 0.14 12.5 2.2 2.2 3 0 0 3 3 3 0 Secretin N-terminal domain Form_Nir_trans PF01226.12 CDI76813.1 - 2.9e-46 157.4 8.3 3.8e-46 157.0 5.8 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter LANC_like PF05147.8 CDI76815.1 - 9.2e-27 93.5 1.4 1.9e-12 46.4 0.0 4.2 4 0 0 4 4 4 4 Lanthionine synthetase C-like protein EF-hand_7 PF13499.1 CDI76816.1 - 0.0097 16.0 0.1 0.015 15.3 0.0 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 CDI76816.1 - 0.037 13.6 1.1 0.41 10.2 0.5 2.2 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_9 PF14658.1 CDI76816.1 - 0.079 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Med15 PF09606.5 CDI76817.1 - 4.5 5.3 21.7 5 5.2 15.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Toxin_56 PF15534.1 CDI76818.1 - 0.2 12.1 2.1 1 9.9 1.5 1.9 1 1 0 1 1 1 0 Putative toxin 56 DUF3154 PF11351.3 CDI76819.1 - 2.6 7.7 5.4 1.6 8.4 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3154) SHMT PF00464.14 CDI76820.1 - 1.3e-165 550.6 0.0 1.5e-165 550.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.12 CDI76820.1 - 0.15 11.0 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family PI3_PI4_kinase PF00454.22 CDI76821.1 - 2.8e-25 89.1 0.0 4.7e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Phage_head_fibr PF11133.3 CDI76822.1 - 0.094 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Head fiber protein PC_rep PF01851.17 CDI76823.1 - 2.1e-10 40.2 33.4 0.00029 20.8 0.1 9.0 9 0 0 9 9 9 5 Proteasome/cyclosome repeat HEAT_2 PF13646.1 CDI76823.1 - 0.011 15.9 8.3 0.077 13.2 0.0 4.5 4 1 1 5 5 5 0 HEAT repeats ThiF PF00899.16 CDI76824.1 - 3.2e-30 104.7 0.0 5.6e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.4 CDI76824.1 - 7.1e-21 73.3 0.3 2.1e-20 71.8 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UBACT PF02134.16 CDI76824.1 - 3.4e-09 36.1 0.2 1.1e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein BAF1_ABF1 PF04684.8 CDI76824.1 - 0.0025 16.7 11.0 0.0025 16.7 7.6 2.4 2 0 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor DUF3439 PF11921.3 CDI76824.1 - 0.06 13.1 4.0 0.21 11.3 2.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Neur_chan_memb PF02932.11 CDI76824.1 - 0.28 11.0 12.0 0.21 11.4 0.7 2.8 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.17 CDI76824.1 - 2.5 7.0 5.2 0.52 9.2 0.3 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Guanylate_cyc PF00211.15 CDI76825.1 - 1.9e-36 125.1 0.0 3.2e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CaMBD PF02888.11 CDI76830.1 - 0.047 13.4 0.3 0.07 12.9 0.2 1.2 1 0 0 1 1 1 0 Calmodulin binding domain CD34_antigen PF06365.7 CDI76830.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF912 PF06024.7 CDI76830.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 CDI76830.1 - 0.18 10.0 0.0 0.24 9.6 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF1180 PF06679.7 CDI76830.1 - 2 8.2 5.2 94 2.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF1517 PF07466.6 CDI76830.1 - 3.1 6.7 5.1 5.9 5.7 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) DUF4551 PF15087.1 CDI76832.1 - 0.018 13.4 30.3 0.019 13.3 21.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CAF-1_p150 PF11600.3 CDI76832.1 - 0.65 9.3 48.3 0.77 9.1 33.5 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PAT1 PF09770.4 CDI76832.1 - 1.4 7.1 84.2 1.6 6.8 58.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI76833.1 - 0.0024 16.1 12.8 0.0024 16.1 8.9 6.6 5 2 2 7 7 7 2 ARC105 or Med15 subunit of Mediator complex non-fungal N6_N4_Mtase PF01555.13 CDI76833.1 - 0.16 11.4 0.0 39 3.6 0.0 3.7 3 2 0 3 3 3 0 DNA methylase Suf PF05843.9 CDI76833.1 - 1.8 8.1 62.2 0.031 14.0 1.0 6.0 6 1 0 6 6 6 0 Suppressor of forked protein (Suf) zf-DHHC PF01529.15 CDI76833.1 - 3 7.2 22.2 0.4 10.0 0.1 4.7 5 0 0 5 5 5 0 DHHC palmitoyltransferase zf-C3HC4_2 PF13923.1 CDI76834.1 - 2e-05 24.5 5.9 0.079 12.9 0.3 3.3 2 2 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Baculo_RING PF05883.6 CDI76834.1 - 0.003 17.4 1.0 1.8 8.3 0.1 2.3 2 0 0 2 2 2 2 Baculovirus U-box/Ring-like domain zf-C3HC4 PF00097.20 CDI76834.1 - 0.14 11.8 10.7 4.7 6.9 0.9 3.9 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI76834.1 - 0.34 10.7 14.7 2.7 7.8 2.3 3.0 2 2 0 2 2 2 0 Ring finger domain DUF4171 PF13775.1 CDI76834.1 - 1.7 8.7 27.2 1.7 8.8 6.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) DUF3761 PF12587.3 CDI76834.1 - 5 7.2 11.2 4.7 7.3 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) DUF1980 PF09323.5 CDI76834.1 - 7 6.3 10.1 0.093 12.4 0.6 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF1980) zf-met PF12874.2 CDI76835.1 - 2.2e-08 33.9 3.5 2.9e-05 24.1 0.4 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 CDI76835.1 - 3.4e-08 33.3 3.9 0.0038 17.4 0.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 CDI76835.1 - 6.6e-08 32.2 1.9 0.0022 17.8 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.1 CDI76835.1 - 1.4e-07 31.3 3.7 0.0024 18.1 0.0 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDI76835.1 - 5.8e-07 29.4 4.5 1.8e-05 24.7 1.1 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 CDI76835.1 - 3.7e-06 26.9 14.5 0.0049 16.9 0.8 3.8 3 1 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.7 CDI76835.1 - 0.3 10.7 2.8 0.72 9.5 0.4 2.5 3 0 0 3 3 3 0 DBF zinc finger Kinesin PF00225.18 CDI76836.1 - 9.9e-66 221.7 0.0 1.2e-40 139.2 0.0 2.7 3 0 0 3 3 3 2 Kinesin motor domain Solute_trans_a PF03619.11 CDI76836.1 - 4.5e-24 85.2 3.8 4e-12 46.0 0.1 3.2 3 0 0 3 3 3 3 Organic solute transporter Ostalpha TPR_11 PF13414.1 CDI76839.1 - 1.1e-12 47.3 6.5 1e-07 31.4 0.3 2.9 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 CDI76839.1 - 7.2e-10 38.0 2.1 0.066 13.1 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 CDI76839.1 - 1e-08 34.3 2.0 0.032 13.8 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat Aha1_N PF09229.6 CDI76839.1 - 1.7e-08 34.3 0.1 7.3e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal TPR_16 PF13432.1 CDI76839.1 - 8.9e-06 26.2 5.5 0.00039 20.9 1.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI76839.1 - 3.9e-05 23.9 4.8 0.041 14.5 0.6 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDI76839.1 - 0.0002 21.1 1.0 0.00093 18.9 0.3 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDI76839.1 - 0.00063 20.0 6.6 0.00068 19.9 1.8 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDI76839.1 - 0.0012 19.1 2.8 2 9.0 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDI76839.1 - 0.0071 16.2 1.2 3.8 7.4 0.0 3.2 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat Apc3 PF12895.2 CDI76839.1 - 0.015 15.4 2.9 0.035 14.2 1.1 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 CDI76839.1 - 0.05 13.8 1.1 0.35 11.1 0.1 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_20 PF14561.1 CDI76839.1 - 0.076 13.1 6.9 0.056 13.5 2.5 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDI76839.1 - 0.081 12.8 2.1 1.2 9.1 0.1 2.6 1 1 2 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 CDI76839.1 - 0.083 12.7 3.5 0.11 12.3 0.1 2.9 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF4530 PF15039.1 CDI76839.1 - 0.17 11.7 2.8 0.3 11.0 1.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4530) TPR_8 PF13181.1 CDI76839.1 - 0.37 10.6 6.3 4.9 7.1 0.0 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF755 PF05501.6 CDI76839.1 - 1.2 9.1 12.2 3 7.9 8.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Trehalose_PPase PF02358.11 CDI76840.1 - 3.1e-26 91.7 0.0 4.2e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Trehalose-phosphatase AAA_8 PF12780.2 CDI76842.1 - 4.1e-87 291.5 0.0 8.7e-87 290.4 0.0 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.2 CDI76842.1 - 2.8e-60 203.8 17.5 1.9e-59 201.1 12.0 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 CDI76842.1 - 2.3e-43 148.2 0.1 4.7e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 DUF4061 PF13270.1 CDI76842.1 - 0.02 15.0 3.3 0.36 10.9 0.4 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) INCA1 PF15142.1 CDI76842.1 - 0.023 14.4 1.2 0.047 13.4 0.8 1.4 1 0 0 1 1 1 0 INCA1 Complex1_LYR_2 PF13233.1 CDI76842.1 - 0.12 12.8 3.3 0.34 11.4 0.0 3.1 3 0 0 3 3 3 0 Complex1_LYR-like Fib_alpha PF08702.5 CDI76842.1 - 0.85 9.7 14.6 0.5 10.4 2.1 2.9 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.7 CDI76842.1 - 0.98 9.7 7.0 0.28 11.4 0.3 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4446 PF14584.1 CDI76842.1 - 2.3 8.0 9.7 0.049 13.4 0.5 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) Laminin_II PF06009.7 CDI76842.1 - 6.7 6.4 18.3 0.8 9.4 4.0 3.0 2 1 1 3 3 3 0 Laminin Domain II PK PF00224.16 CDI76844.1 - 4.6e-73 245.8 0.0 7.6e-33 113.5 0.2 3.1 3 0 0 3 3 3 3 Pyruvate kinase, barrel domain PK_C PF02887.11 CDI76844.1 - 9.9e-12 44.4 2.4 7.2e-10 38.4 0.0 3.1 3 0 0 3 3 3 1 Pyruvate kinase, alpha/beta domain Med15 PF09606.5 CDI76844.1 - 5.4e-05 21.6 10.2 5.4e-05 21.6 7.0 3.1 3 1 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.3 CDI76844.1 - 0.066 12.5 4.3 0.47 9.7 0.2 2.2 2 0 0 2 2 2 0 Spt20 family RNA_lig_T4_1 PF09511.5 CDI76844.1 - 0.45 9.9 1.1 1.3 8.4 0.0 2.0 2 0 0 2 2 2 0 RNA ligase SGT1 PF07093.6 CDI76844.1 - 9 4.5 10.6 0.46 8.8 0.6 2.0 2 0 0 2 2 2 0 SGT1 protein Herpes_gE PF02480.11 CDI76845.1 - 0.07 11.3 0.0 0.15 10.2 0.0 1.6 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E RF-1 PF00472.15 CDI76846.1 - 1.4e-33 115.0 1.1 1.4e-33 115.0 0.8 4.8 6 0 0 6 6 6 1 RF-1 domain PCRF PF03462.13 CDI76846.1 - 1.8e-19 69.5 1.2 1.8e-19 69.5 0.9 2.8 2 1 0 2 2 2 1 PCRF domain Aldedh PF00171.17 CDI76847.1 - 0.00021 19.7 5.3 0.00087 17.7 0.0 2.9 3 0 0 3 3 3 1 Aldehyde dehydrogenase family DAO PF01266.19 CDI76847.1 - 0.067 12.0 0.8 4.6 6.0 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF2237 PF09996.4 CDI76847.1 - 0.092 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) Kv2channel PF03521.9 CDI76847.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Kv2 voltage-gated K+ channel zf-CCCH PF00642.19 CDI76848.1 - 9.5e-09 34.7 21.2 5.7e-07 29.0 2.1 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CDI76848.1 - 0.0011 18.9 12.0 0.046 13.7 1.0 4.0 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type zf-C3H1 PF10650.4 CDI76848.1 - 0.024 14.1 7.3 0.53 9.8 0.2 3.4 3 0 0 3 3 3 0 Putative zinc-finger domain SR-25 PF10500.4 CDI76851.1 - 0.0043 16.5 9.3 0.0043 16.5 6.4 3.9 2 1 1 3 3 3 2 Nuclear RNA-splicing-associated protein Apt1 PF10351.4 CDI76851.1 - 3.7 6.3 10.9 4.8 5.9 0.2 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain PAT1 PF09770.4 CDI76855.1 - 0.16 10.1 61.3 0.19 9.8 42.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1510 PF07423.6 CDI76855.1 - 0.73 9.1 36.8 0.12 11.7 17.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Med15 PF09606.5 CDI76855.1 - 2.3 6.3 81.4 3.8 5.5 56.4 1.4 1 1 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BAF1_ABF1 PF04684.8 CDI76856.1 - 3.9e-06 26.0 18.1 3.9e-06 26.0 12.5 3.3 1 1 3 4 4 4 1 BAF1 / ABF1 chromatin reorganising factor DUF605 PF04652.11 CDI76856.1 - 0.00057 19.4 29.5 0.00068 19.1 20.4 1.1 1 0 0 1 1 1 1 Vta1 like Utp14 PF04615.8 CDI76856.1 - 0.5 8.4 26.6 0.66 8.0 18.4 1.1 1 0 0 1 1 1 0 Utp14 protein PAT1 PF09770.4 CDI76856.1 - 0.58 8.3 27.6 1 7.5 19.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LMBR1 PF04791.11 CDI76856.1 - 2.1 6.8 9.6 2.4 6.6 6.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.7 CDI76856.1 - 4.2 7.1 16.8 6.8 6.5 11.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_60s PF00428.14 CDI76857.1 - 0.11 12.9 7.7 0.27 11.6 5.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Enolase_N PF03952.11 CDI76857.1 - 2.2 8.2 7.8 2.2 8.2 4.9 1.4 1 1 0 1 1 1 0 Enolase, N-terminal domain PLRV_ORF5 PF01690.12 CDI76857.1 - 3.1 6.8 34.8 3.8 6.5 24.1 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein ARA70 PF12489.3 CDI76858.1 - 0.013 15.4 7.7 0.013 15.4 5.3 3.5 3 0 0 3 3 3 0 Nuclear coactivator Cortexin PF11057.3 CDI76858.1 - 0.28 10.8 2.0 2.8 7.6 0.0 3.2 3 0 0 3 3 3 0 Cortexin of kidney Acyl_transf_3 PF01757.17 CDI76858.1 - 0.52 9.1 12.7 0.081 11.7 5.8 1.8 2 0 0 2 2 2 0 Acyltransferase family TFIIA PF03153.8 CDI76858.1 - 3.3 7.5 36.1 0.2 11.5 4.6 3.1 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.1 CDI76861.1 - 2.8 7.6 32.8 3 7.5 22.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF3729 PF12526.3 CDI76861.1 - 7.9 7.8 12.2 14 7.0 8.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3729) Suf PF05843.9 CDI76862.1 - 0.33 10.6 4.1 0.39 10.4 2.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.8 CDI76862.1 - 0.79 9.5 16.6 0.93 9.3 11.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI76862.1 - 1.4 7.0 21.1 1.6 6.8 14.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3533 PF12051.3 CDI76862.1 - 1.6 7.4 4.4 2.2 6.9 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Ribosomal_S10 PF00338.17 CDI76864.1 - 8.6e-07 28.7 0.2 8.6e-07 28.7 0.1 2.7 3 1 0 3 3 3 1 Ribosomal protein S10p/S20e Macoilin PF09726.4 CDI76864.1 - 1.3e-06 27.0 32.1 1.3e-06 27.0 22.2 2.5 2 1 0 2 2 2 1 Transmembrane protein Herpes_UL87 PF03043.9 CDI76864.1 - 0.62 8.3 23.3 0.011 14.0 10.5 2.1 2 1 0 2 2 2 0 Herpesvirus UL87 family DUF4422 PF14393.1 CDI76864.1 - 2.5 7.6 11.6 2.5 7.6 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4422) NifQ PF04891.7 CDI76864.1 - 7.2 6.7 21.7 0.23 11.6 2.1 2.9 2 0 0 2 2 2 0 NifQ RNA_pol_Rpc4 PF05132.9 CDI76866.1 - 3.7e-07 30.1 0.0 3.7e-07 30.1 0.0 5.4 5 0 0 5 5 5 3 RNA polymerase III RPC4 DUF572 PF04502.8 CDI76866.1 - 9.5 5.3 49.9 1.2 8.2 16.4 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF572) NPL4 PF05021.10 CDI76868.1 - 1.8e-24 86.4 0.0 7.4e-23 81.1 0.0 2.4 1 1 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 CDI76868.1 - 4.3e-05 23.1 0.1 9.4e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Pex14_N PF04695.8 CDI76868.1 - 0.31 11.0 7.2 0.11 12.4 0.5 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RAP1 PF07218.6 CDI76868.1 - 4.9 5.1 10.6 5.6 4.9 7.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pilus_PilP PF11356.3 CDI76868.1 - 7.8 6.8 6.7 0.76 10.0 0.2 2.2 2 0 0 2 2 2 0 Type IV pilus biogenesis DUF4179 PF13786.1 CDI76869.1 - 0.18 12.0 2.5 0.24 11.6 1.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) IncA PF04156.9 CDI76869.1 - 0.31 10.6 24.8 0.35 10.4 17.2 1.1 1 0 0 1 1 1 0 IncA protein FHIPEP PF00771.15 CDI76869.1 - 0.37 9.0 11.6 0.45 8.7 8.1 1.2 1 0 0 1 1 1 0 FHIPEP family Ctr PF04145.10 CDI76869.1 - 0.53 10.3 9.9 0.63 10.0 6.9 1.1 1 0 0 1 1 1 0 Ctr copper transporter family DUF2215 PF10225.4 CDI76869.1 - 0.58 9.5 10.2 0.57 9.5 7.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) OATP PF03137.15 CDI76869.1 - 0.6 8.1 13.2 0.66 7.9 9.2 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family C_GCAxxG_C_C PF09719.5 CDI76869.1 - 0.9 9.3 5.2 1.1 9.0 3.6 1.2 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) FAM176 PF14851.1 CDI76869.1 - 0.91 9.1 10.9 0.99 9.0 7.6 1.1 1 0 0 1 1 1 0 FAM176 family DUF3824 PF12868.2 CDI76869.1 - 0.95 10.3 13.4 1.2 10.0 9.3 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) R_equi_Vir PF05526.6 CDI76869.1 - 1.6 8.3 14.9 1.8 8.1 10.4 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein MelC1 PF06236.6 CDI76869.1 - 1.7 8.6 11.8 2.1 8.3 8.2 1.1 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 FYDLN_acid PF09538.5 CDI76869.1 - 2.1 8.9 11.4 2.7 8.6 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) FLO_LFY PF01698.11 CDI76869.1 - 2.7 6.7 20.8 2.8 6.6 14.4 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Trp_oprn_chp PF09534.5 CDI76869.1 - 2.7 7.5 11.2 3.4 7.2 7.7 1.3 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Serinc PF03348.10 CDI76869.1 - 3.4 6.2 18.7 3.6 6.1 12.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) AIF_C PF14721.1 CDI76869.1 - 3.9 7.7 18.8 4.3 7.5 13.1 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pox_Ag35 PF03286.9 CDI76869.1 - 4.4 6.7 14.5 4.4 6.7 10.0 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FimP PF09766.4 CDI76869.1 - 4.4 6.2 33.3 6.7 5.6 23.1 1.3 1 0 0 1 1 1 0 Fms-interacting protein DUF2232 PF09991.4 CDI76869.1 - 4.6 6.1 10.0 5.3 5.9 7.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Folate_carrier PF01770.13 CDI76869.1 - 5.4 5.4 13.2 5.6 5.3 9.2 1.0 1 0 0 1 1 1 0 Reduced folate carrier DUF1510 PF07423.6 CDI76869.1 - 5.9 6.1 22.9 6.2 6.1 15.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pal1 PF08316.6 CDI76869.1 - 6.6 7.1 12.8 7.3 7.0 8.9 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein FAM60A PF15396.1 CDI76869.1 - 6.7 6.3 15.5 7.1 6.3 10.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A P5-ATPase PF12409.3 CDI76869.1 - 7.2 6.4 8.1 7.7 6.4 5.6 1.2 1 0 0 1 1 1 0 P5-type ATPase cation transporter SspB PF04386.8 CDI76869.1 - 7.9 6.0 17.5 9.2 5.8 12.1 1.1 1 0 0 1 1 1 0 Stringent starvation protein B KR PF08659.5 CDI76870.1 - 4.1e-52 176.4 0.0 4.7e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CDI76870.1 - 6e-40 136.8 0.0 6.9e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDI76870.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 CDI76870.1 - 0.023 14.1 0.0 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CDI76871.1 - 1.5e-53 181.3 0.0 2.4e-53 180.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Sulfotransfer_1 PF00685.22 CDI76871.1 - 2.7e-17 62.8 0.2 6.2e-17 61.7 0.1 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 CDI76871.1 - 2.9e-14 54.2 0.0 8.4e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 Sulfotransferase family PP-binding PF00550.20 CDI76871.1 - 4.6e-11 42.8 0.0 1.5e-10 41.1 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 CDI76871.1 - 2.4e-08 33.7 0.0 4.7e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1331 PF07048.6 CDI76871.1 - 0.089 12.2 0.2 0.65 9.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1331) IMCp PF12314.3 CDI76872.1 - 2.1e-29 101.4 59.6 2.2e-28 98.2 27.6 5.7 2 2 3 5 5 5 2 Inner membrane complex protein IMCp PF12314.3 CDI76873.1 - 3.3e-33 113.6 94.3 6.8e-18 64.6 20.4 4.8 1 1 3 4 4 4 4 Inner membrane complex protein LSM PF01423.17 CDI76874.1 - 1.1e-14 53.7 0.7 2e-14 52.8 0.5 1.5 1 0 0 1 1 1 1 LSM domain DUF2335 PF10097.4 CDI76874.1 - 0.38 10.4 2.7 6.3 6.5 0.0 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2335) Nucleoside_tran PF01733.13 CDI76877.1 - 1.3e-07 31.0 2.6 1.9e-07 30.5 1.8 1.1 1 0 0 1 1 1 1 Nucleoside transporter NTP_transf_2 PF01909.18 CDI76878.1 - 0.15 12.3 0.1 0.3 11.4 0.1 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain LRR_2 PF07723.8 CDI76880.1 - 0.1 13.1 2.0 21 5.8 0.1 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat zf-CCCH PF00642.19 CDI76882.1 - 0.0036 16.9 0.6 0.0036 16.9 0.4 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1180 PF06679.7 CDI76883.1 - 0.13 12.1 0.1 0.16 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PAT1 PF09770.4 CDI76883.1 - 1.5 6.9 31.0 1.6 6.8 21.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spc97_Spc98 PF04130.8 CDI76885.1 - 0.00054 18.4 0.0 0.00054 18.4 0.0 4.7 3 2 2 5 5 5 2 Spc97 / Spc98 family Cwf_Cwc_15 PF04889.7 CDI76885.1 - 1 9.0 37.1 0.023 14.4 7.7 5.2 5 1 0 5 5 5 0 Cwf15/Cwc15 cell cycle control protein DUF3801 PF12687.2 CDI76885.1 - 1.9 7.9 30.7 0.035 13.6 7.7 4.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3801) CAP PF00188.21 CDI76888.1 - 0.0024 18.3 0.0 0.0034 17.8 0.0 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Syja_N PF02383.13 CDI76893.1 - 2.5e-42 144.7 0.0 4e-40 137.5 0.0 3.1 2 1 0 2 2 2 2 SacI homology domain PX PF00787.19 CDI76895.1 - 8.7e-15 54.4 0.0 2.7e-14 52.9 0.0 1.9 1 0 0 1 1 1 1 PX domain SR-25 PF10500.4 CDI76895.1 - 0.0095 15.4 2.0 0.0095 15.4 1.4 6.1 6 0 0 6 6 6 3 Nuclear RNA-splicing-associated protein Ras PF00071.17 CDI76896.1 - 9.2e-10 38.1 0.0 1.1e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Ras family Miro PF08477.8 CDI76896.1 - 3.8e-08 33.8 0.0 1.2e-07 32.1 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 CDI76896.1 - 0.00066 19.1 0.0 0.0019 17.6 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI76896.1 - 0.017 15.0 0.0 0.1 12.5 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.1 CDI76896.1 - 0.033 14.0 0.0 0.14 12.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain Methyltransf_18 PF12847.2 CDI76897.1 - 6.4e-06 26.7 0.0 1.1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI76897.1 - 0.0001 22.3 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI76897.1 - 0.00044 20.5 0.0 0.00091 19.5 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI76897.1 - 0.0089 15.6 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI76897.1 - 0.01 16.2 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.20 CDI76899.1 - 2e-32 112.3 0.0 2.2e-15 56.5 0.0 3.3 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI76899.1 - 1.7e-09 37.1 0.0 0.0046 16.0 0.0 3.8 3 0 0 3 3 3 3 Protein tyrosine kinase ThiF PF00899.16 CDI76900.1 - 1.5e-06 28.0 0.1 8.1e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 ThiF family PAT1 PF09770.4 CDI76900.1 - 0.0074 14.5 54.4 0.015 13.6 37.7 1.4 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Cullin_binding PF03556.10 CDI76901.1 - 7.9e-23 80.8 0.3 9.1e-15 54.8 0.0 2.4 2 0 0 2 2 2 2 Cullin binding UBA_4 PF14555.1 CDI76901.1 - 8.7e-11 41.1 0.0 3e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 UBA-like domain DUF1296 PF06972.6 CDI76901.1 - 0.026 14.5 0.3 1.1 9.2 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1296) Cytochrome-c551 PF10643.4 CDI76901.1 - 0.16 11.2 1.9 0.29 10.4 1.3 1.4 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 IQ PF00612.22 CDI76902.1 - 0.007 15.9 0.2 0.021 14.4 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif Hydrolase_3 PF08282.7 CDI76904.1 - 7.1e-42 143.7 0.0 8.5e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 CDI76904.1 - 1e-06 28.2 0.0 8.1e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase PFK PF00365.15 CDI76905.1 - 1.7e-30 105.9 0.1 2.6e-22 79.0 0.0 2.2 2 0 0 2 2 2 2 Phosphofructokinase Metallophos PF00149.23 CDI76907.1 - 0.0041 16.5 0.0 0.0048 16.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase P22_CoatProtein PF11651.3 CDI76908.1 - 0.01 14.4 0.3 0.019 13.5 0.2 1.3 1 0 0 1 1 1 0 P22 coat protein - gene protein 5 TFIIA PF03153.8 CDI76909.1 - 0.027 14.3 14.2 0.036 13.9 2.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Metallophos PF00149.23 CDI76910.1 - 1.6e-36 125.6 0.1 2.2e-36 125.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_4 PF13418.1 CDI76910.1 - 3.9e-05 23.3 0.9 0.0026 17.5 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI76910.1 - 0.00018 21.3 0.0 0.00076 19.3 0.0 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.20 CDI76910.1 - 0.00031 20.2 0.8 0.0094 15.4 0.0 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.10 CDI76910.1 - 0.0082 15.8 0.1 0.039 13.7 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.1 CDI76910.1 - 0.027 14.6 4.3 0.27 11.4 0.0 3.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_6 PF13964.1 CDI76910.1 - 0.16 12.1 0.3 2.5 8.3 0.0 2.7 3 0 0 3 3 3 0 Kelch motif PAT1 PF09770.4 CDI76910.1 - 0.34 9.1 19.6 0.47 8.6 13.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WD40 PF00400.27 CDI76911.1 - 7e-38 127.1 20.7 3.7e-11 42.4 0.1 8.4 8 1 0 8 8 8 5 WD domain, G-beta repeat Nup160 PF11715.3 CDI76911.1 - 0.00046 18.4 3.8 1.1 7.3 0.0 3.5 4 0 0 4 4 4 3 Nucleoporin Nup120/160 Abhydrolase_5 PF12695.2 CDI76912.1 - 2e-17 63.3 0.0 3.1e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI76912.1 - 1.3e-09 38.3 0.9 4.6e-06 26.6 0.2 2.5 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CDI76912.1 - 4.4e-09 35.8 1.1 1.3e-06 27.7 0.0 3.0 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 CDI76912.1 - 0.0003 20.2 0.1 0.0041 16.5 0.1 2.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 CDI76912.1 - 0.00035 20.2 0.3 0.0012 18.4 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.7 CDI76912.1 - 0.035 12.8 0.1 0.068 11.8 0.1 1.4 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Abhydrolase_4 PF08386.5 CDI76912.1 - 0.046 13.6 0.0 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 TAP-like protein FSH1 PF03959.8 CDI76912.1 - 0.055 12.8 0.1 0.18 11.2 0.0 1.9 1 1 1 2 2 2 0 Serine hydrolase (FSH1) H-K_ATPase_N PF09040.6 CDI76912.1 - 0.14 12.2 0.2 0.25 11.4 0.1 1.3 1 0 0 1 1 1 0 Gastric H+/K+-ATPase, N terminal domain Pkinase PF00069.20 CDI76913.1 - 8e-11 41.5 0.0 8e-11 41.5 0.0 3.2 4 0 0 4 4 4 1 Protein kinase domain zf-DHHC PF01529.15 CDI76915.1 - 0.0094 15.3 6.7 0.025 13.9 4.6 1.7 1 1 0 1 1 1 1 DHHC palmitoyltransferase DUF3317 PF11779.3 CDI76915.1 - 0.016 14.6 0.4 0.016 14.6 0.3 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3317) dDENN PF03455.14 CDI76915.1 - 0.093 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 dDENN domain Colicin_V PF02674.11 CDI76915.1 - 1.9 8.3 10.1 0.25 11.1 1.7 2.3 2 0 0 2 2 2 0 Colicin V production protein DPM3 PF08285.6 CDI76915.1 - 4.3 7.2 6.4 8.7 6.2 2.1 2.3 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) RseC_MucC PF04246.7 CDI76915.1 - 5.2 6.6 5.9 4.1 6.9 1.1 2.3 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC START PF01852.14 CDI76917.1 - 0.0002 20.7 0.0 0.00037 19.8 0.0 1.4 1 0 0 1 1 1 1 START domain TP_methylase PF00590.15 CDI76919.1 - 4.8e-22 78.7 0.1 8.1e-22 77.9 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UQ_con PF00179.21 CDI76920.1 - 4e-47 159.1 0.1 4.6e-47 158.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDI76920.1 - 9.1e-05 22.2 0.0 0.0001 22.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDI76920.1 - 0.00071 19.4 0.0 0.00086 19.1 0.0 1.2 1 0 0 1 1 1 1 RWD domain Rhomboid PF01694.17 CDI76923.1 - 2.7e-15 56.6 6.7 5e-15 55.8 4.6 1.4 1 0 0 1 1 1 1 Rhomboid family CoaE PF01121.15 CDI76925.1 - 4.2e-48 163.1 0.0 5.4e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_28 PF13521.1 CDI76925.1 - 5.3e-05 23.2 0.0 9.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDI76925.1 - 0.0006 20.6 0.0 0.001 19.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDI76925.1 - 0.022 15.0 0.1 0.075 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain APG5 PF04106.7 CDI76928.1 - 3.6e-25 88.5 0.0 1.1e-24 86.9 0.0 1.8 1 1 0 1 1 1 1 Autophagy protein Apg5 DUF1880 PF08976.6 CDI76928.1 - 0.08 13.0 0.6 0.18 11.9 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1880) BAF1_ABF1 PF04684.8 CDI76929.1 - 6.7 5.4 9.3 13 4.4 6.5 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ACPS PF01648.15 CDI76938.1 - 7.7e-14 51.4 0.0 1.6e-13 50.5 0.0 1.5 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily WD40 PF00400.27 CDI76940.1 - 6.6e-13 47.9 10.7 3e-08 33.2 0.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_2 PF13360.1 CDI76940.1 - 0.052 12.9 0.0 0.084 12.3 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain PQQ_3 PF13570.1 CDI76942.1 - 0.013 15.7 1.5 7.1 7.0 0.2 3.7 3 0 0 3 3 3 0 PQQ-like domain BRF1 PF07741.8 CDI76942.1 - 2.2 8.5 6.2 2.2 8.5 0.1 3.0 3 0 0 3 3 3 0 Brf1-like TBP-binding domain CDK2AP PF09806.4 CDI76943.1 - 2.9 8.0 11.6 3.2 7.9 8.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF1635 PF07795.6 CDI76943.1 - 6.7 6.0 6.5 8 5.7 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) WD40 PF00400.27 CDI76944.1 - 3e-10 39.5 7.4 0.081 12.8 0.8 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.3 CDI76944.1 - 0.022 12.9 3.2 0.091 10.8 0.2 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF3245 PF11595.3 CDI76944.1 - 0.11 12.7 2.8 0.16 12.2 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Shadoo PF14999.1 CDI76944.1 - 0.18 11.6 13.1 0.25 11.1 8.7 1.4 1 1 0 1 1 1 0 Shadow of prion protein, neuroprotective Cwf_Cwc_15 PF04889.7 CDI76949.1 - 0.0011 18.7 2.0 0.0011 18.7 1.4 5.1 3 1 1 4 4 4 1 Cwf15/Cwc15 cell cycle control protein Kelch_1 PF01344.20 CDI76951.1 - 3.5e-15 55.2 0.0 8.5e-07 28.4 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 CDI76951.1 - 8.8e-14 51.0 2.4 1e-07 31.6 0.1 2.2 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 CDI76951.1 - 2.3e-12 46.6 2.1 8.4e-06 25.8 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 CDI76951.1 - 4.2e-11 42.1 1.7 3.2e-05 23.5 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 CDI76951.1 - 2.3e-09 37.0 0.7 5.9e-05 23.0 0.1 2.3 1 1 1 2 2 2 2 Kelch motif Kelch_5 PF13854.1 CDI76951.1 - 3.8e-09 36.3 0.4 0.0021 17.9 0.1 2.3 2 0 0 2 2 2 2 Kelch motif RAMP4 PF06624.7 CDI76955.1 - 1.4e-16 59.7 0.2 2.8e-16 58.8 0.2 1.6 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Avl9 PF09794.4 CDI76956.1 - 2.8e-15 55.6 0.0 5.7e-14 51.3 0.0 2.3 1 1 0 1 1 1 1 Transport protein Avl9 DENN PF02141.16 CDI76956.1 - 0.0028 17.4 0.2 0.016 14.9 0.1 2.2 2 0 0 2 2 2 1 DENN (AEX-3) domain SPA PF08616.5 CDI76956.1 - 0.0039 16.8 0.0 0.081 12.6 0.0 2.4 2 0 0 2 2 2 1 Stabilization of polarity axis MORN PF02493.15 CDI76957.1 - 1.4e-25 87.3 37.5 0.00015 21.2 0.2 9.4 10 0 0 10 10 10 7 MORN repeat eIF3_p135 PF12807.2 CDI76958.1 - 6.9e-08 32.6 0.1 2.5e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 DSPc PF00782.15 CDI76959.1 - 1.3e-22 79.8 0.0 2.8e-18 65.7 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDI76959.1 - 0.0026 17.1 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase AAA_12 PF13087.1 CDI76960.1 - 1.1e-50 171.8 0.0 3e-50 170.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 CDI76960.1 - 3e-42 144.8 0.4 8.2e-41 140.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDI76960.1 - 2.9e-09 36.5 0.3 1.4e-08 34.3 0.0 2.2 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 CDI76960.1 - 6.8e-06 25.7 0.8 0.00011 21.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain dsrm PF00035.20 CDI76960.1 - 9.7e-05 22.8 0.9 0.091 13.3 0.0 3.0 2 0 0 2 2 2 2 Double-stranded RNA binding motif PIF1 PF05970.9 CDI76960.1 - 0.0011 18.0 0.0 0.12 11.2 0.0 2.3 2 0 0 2 2 2 2 PIF1-like helicase IstB_IS21 PF01695.12 CDI76960.1 - 0.011 15.1 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 CDI76960.1 - 0.13 11.9 0.0 0.38 10.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain G-patch PF01585.18 CDI76961.1 - 7e-14 51.3 1.0 1.3e-13 50.5 0.7 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 CDI76961.1 - 0.0016 18.2 0.5 0.0016 18.2 0.3 1.9 2 0 0 2 2 2 1 DExH-box splicing factor binding site RRM_1 PF00076.17 CDI76961.1 - 0.0019 17.7 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI76961.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4574 PF15141.1 CDI76961.1 - 0.021 14.5 0.1 0.12 12.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4574) COPI_assoc PF08507.5 CDI76963.1 - 1.2e-11 44.4 0.5 1.4e-11 44.2 0.4 1.1 1 0 0 1 1 1 1 COPI associated protein CD20 PF04103.10 CDI76965.1 - 0.076 12.9 0.3 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 CD20-like family DUF1633 PF07794.6 CDI76966.1 - 5.6 4.7 8.0 6.5 4.5 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Ribosomal_L22 PF00237.14 CDI76968.1 - 2.1e-08 34.0 0.2 3.3e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e zf-RING_2 PF13639.1 CDI76969.1 - 4.8e-07 29.4 8.5 1.8e-06 27.6 3.0 2.6 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CDI76969.1 - 9.4e-06 25.6 2.1 1.8e-05 24.7 0.7 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 CDI76969.1 - 0.00015 21.3 5.1 0.00058 19.5 1.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDI76969.1 - 0.00017 21.5 8.7 0.0056 16.6 2.9 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI76969.1 - 0.0026 17.3 7.8 0.011 15.3 2.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDI76969.1 - 0.0027 17.3 7.6 0.005 16.4 2.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDI76969.1 - 0.037 13.8 1.7 0.084 12.7 1.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 CDI76969.1 - 0.36 10.7 6.8 0.27 11.1 1.6 2.8 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Protamine_P2 PF00841.14 CDI76969.1 - 3.8 8.1 10.2 7.8 7.1 7.1 1.4 1 0 0 1 1 1 0 Sperm histone P2 zf-RING_UBOX PF13445.1 CDI76969.1 - 4.2 7.1 10.0 0.85 9.3 0.3 3.2 3 0 0 3 3 3 0 RING-type zinc-finger Spt20 PF12090.3 CDI76970.1 - 0.0012 18.2 2.3 0.0013 18.1 1.6 1.3 1 0 0 1 1 1 1 Spt20 family DUF4557 PF15101.1 CDI76970.1 - 0.0014 18.5 5.3 0.0014 18.5 3.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4557) RAB3GAP2_N PF14655.1 CDI76970.1 - 0.0064 15.5 2.7 0.0078 15.2 1.9 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus zf-DHHC PF01529.15 CDI76970.1 - 0.084 12.2 0.2 0.081 12.3 0.2 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase CPSF100_C PF13299.1 CDI76970.1 - 0.11 12.6 4.5 0.13 12.4 3.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Herpes_DNAp_acc PF04929.7 CDI76970.1 - 0.12 11.3 3.2 0.12 11.2 2.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor FimP PF09766.4 CDI76970.1 - 0.33 9.9 17.5 0.37 9.7 12.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein DUF4407 PF14362.1 CDI76970.1 - 0.74 8.7 7.7 0.75 8.6 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Suf PF05843.9 CDI76970.1 - 0.87 9.2 13.3 0.47 10.1 7.9 1.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI76970.1 - 4.1 5.5 22.8 4.4 5.4 15.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.8 CDI76970.1 - 5.4 7.0 15.2 1.6 8.7 8.7 1.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gag_spuma PF03276.9 CDI76970.1 - 10 4.3 22.1 11 4.1 15.3 1.0 1 0 0 1 1 1 0 Spumavirus gag protein Glyco_transf_6 PF03414.8 CDI76971.1 - 0.044 12.2 7.3 0.051 12.0 5.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 6 HlyD_2 PF12700.2 CDI76971.1 - 0.075 12.1 14.3 0.09 11.9 9.9 1.1 1 0 0 1 1 1 0 HlyD family secretion protein PAT1 PF09770.4 CDI76971.1 - 2.1 6.4 53.7 2.3 6.3 37.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI76971.1 - 2.3 5.8 12.6 2.4 5.7 8.7 1.1 1 0 0 1 1 1 0 Ycf1 Med15 PF09606.5 CDI76971.1 - 2.7 6.0 73.0 3.4 5.7 50.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.11 CDI76971.1 - 3.6 7.4 8.6 4.3 7.1 5.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDK5_activator PF03261.10 CDI76971.1 - 8.2 5.6 15.2 12 5.1 10.5 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Vfa1 PF08432.5 CDI76973.1 - 0.27 11.2 27.0 0.31 11.0 18.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop25 PF09805.4 CDI76973.1 - 1 9.4 22.6 1.1 9.3 15.6 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) FRQ PF09421.5 CDI76973.1 - 2.2 5.9 13.0 2.4 5.8 9.0 1.0 1 0 0 1 1 1 0 Frequency clock protein NOA36 PF06524.7 CDI76973.1 - 2.3 7.3 17.2 2.5 7.3 11.9 1.0 1 0 0 1 1 1 0 NOA36 protein DUF3449 PF11931.3 CDI76973.1 - 2.5 7.5 16.0 2.9 7.3 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) MIP-T3 PF10243.4 CDI76973.1 - 2.7 6.3 26.2 2.9 6.2 18.2 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.6 CDI76973.1 - 3.9 6.7 29.2 4.4 6.6 20.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FYDLN_acid PF09538.5 CDI76973.1 - 4.1 8.0 24.1 5.3 7.6 16.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF2457 PF10446.4 CDI76973.1 - 4.2 6.0 21.9 5.3 5.6 15.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC27 PF09507.5 CDI76973.1 - 6.7 5.8 26.2 7.1 5.7 18.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Med19 PF10278.4 CDI76973.1 - 7.6 6.1 24.6 8.7 5.9 17.0 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CENP-T PF15511.1 CDI76973.1 - 7.6 5.6 20.1 8 5.5 14.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Ribosomal_60s PF00428.14 CDI76973.1 - 7.9 6.9 22.3 12 6.3 15.5 1.4 1 1 0 1 1 1 0 60s Acidic ribosomal protein DUF605 PF04652.11 CDI76974.1 - 3.3e-06 26.7 2.9 3.3e-06 26.7 2.0 5.8 5 1 0 6 6 6 1 Vta1 like RskA PF10099.4 CDI76974.1 - 0.0056 16.4 0.2 0.0056 16.4 0.1 13.1 6 3 4 10 10 10 3 Anti-sigma-K factor rskA WD40 PF00400.27 CDI76976.1 - 0.00018 21.2 15.5 0.15 12.0 0.0 6.0 8 0 0 8 8 8 3 WD domain, G-beta repeat RRM_5 PF13893.1 CDI76977.1 - 1.3e-07 31.3 0.1 5.8e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI76977.1 - 7.9e-05 22.2 0.1 0.00033 20.2 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI76977.1 - 0.19 11.7 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Phostensin_N PF13916.1 CDI76978.1 - 0.08 12.9 4.2 0.21 11.5 2.9 1.7 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Utp14 PF04615.8 CDI76978.1 - 0.8 7.7 49.8 0.028 12.6 12.4 2.1 2 0 0 2 2 2 0 Utp14 protein SAPS PF04499.10 CDI76978.1 - 1.8 7.0 37.2 0.88 8.1 7.0 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Suf PF05843.9 CDI76979.1 - 0.019 14.6 20.4 0.52 9.9 4.5 2.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Spt20 PF12090.3 CDI76979.1 - 0.059 12.7 17.0 0.024 13.9 1.0 2.9 3 0 0 3 3 3 0 Spt20 family AAA_23 PF13476.1 CDI76979.1 - 0.3 11.4 9.7 0.81 9.9 0.6 2.4 2 0 0 2 2 2 0 AAA domain Anoctamin PF04547.7 CDI76979.1 - 3.8 6.0 6.9 2.1 6.8 0.4 2.2 2 0 0 2 2 2 0 Calcium-activated chloride channel PAT1 PF09770.4 CDI76979.1 - 4.8 5.2 39.4 1.1 7.3 10.4 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Peptidase_S49_N PF08496.5 CDI76979.1 - 7.2 6.3 14.7 5.4 6.7 1.1 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pex14_N PF04695.8 CDI76979.1 - 7.5 6.6 59.8 0.089 12.8 4.0 6.0 5 1 1 6 6 6 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF912 PF06024.7 CDI76979.1 - 8.5 6.4 19.9 17 5.5 0.2 4.9 5 0 0 5 5 5 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Apt1 PF10351.4 CDI76980.1 - 1.2 7.9 24.1 0.39 9.5 0.3 5.1 4 0 0 4 4 4 0 Golgi-body localisation protein domain DUF2020 PF09449.5 CDI76981.1 - 0.0071 16.0 1.1 0.0071 16.0 0.8 3.4 3 1 1 4 4 4 1 Domain of unknown function (DUF2020) SprA-related PF12118.3 CDI76982.1 - 0.00044 19.6 8.4 0.00044 19.6 5.9 1.1 1 0 0 1 1 1 1 SprA-related family Corona_nucleoca PF00937.13 CDI76982.1 - 0.043 12.7 11.4 0.055 12.4 7.9 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RAP1 PF07218.6 CDI76982.1 - 0.11 10.5 17.6 0.14 10.2 12.2 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CAF-1_p150 PF11600.3 CDI76982.1 - 0.53 9.6 16.7 0.7 9.2 11.6 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Period_C PF12114.3 CDI76982.1 - 1.2 8.7 19.4 1.9 8.0 13.4 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Herpes_DNAp_acc PF04929.7 CDI76982.1 - 4.6 6.1 13.2 6.1 5.6 9.2 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor FLO_LFY PF01698.11 CDI76982.1 - 4.7 5.9 7.7 5.6 5.7 5.3 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Ribonuc_red_lgC PF02867.10 CDI76984.1 - 5.6e-92 309.0 0.0 8.2e-67 225.9 0.0 2.3 1 1 1 2 2 2 2 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 CDI76984.1 - 8.5e-22 76.7 0.1 2.5e-21 75.2 0.0 1.9 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 CDI76984.1 - 4.1e-09 36.7 0.0 8.3e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 ATP cone domain Ribosomal_L19e PF01280.15 CDI76986.1 - 3.3e-54 182.6 14.1 1.5e-46 157.8 5.3 2.9 1 1 2 3 3 3 2 Ribosomal protein L19e DUF4358 PF14270.1 CDI76986.1 - 0.0059 16.4 3.1 0.0091 15.8 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4358) YhzD PF14120.1 CDI76986.1 - 1.5 8.7 4.4 0.9 9.4 1.3 1.9 2 0 0 2 2 2 0 YhzD-like protein ELM2 PF01448.19 CDI76990.1 - 7.7 7.2 8.5 0.41 11.3 0.3 2.6 3 0 0 3 3 3 0 ELM2 domain PP2C PF00481.16 CDI76994.1 - 9.4e-21 74.3 0.8 1.7e-07 30.8 0.0 5.1 5 0 0 5 5 5 3 Protein phosphatase 2C S1 PF00575.18 CDI76995.1 - 3.2e-11 43.1 0.0 0.00024 21.1 0.0 3.5 2 1 1 3 3 3 3 S1 RNA binding domain RAP1 PF07218.6 CDI76995.1 - 7.4 4.5 13.4 14 3.6 9.3 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pro_isomerase PF00160.16 CDI76997.1 - 5e-30 104.7 0.4 1.3e-29 103.4 0.0 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med15 PF09606.5 CDI76997.1 - 0.3 9.2 38.7 0.92 7.6 4.7 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 CDI76997.1 - 8.5 6.1 33.2 2.6 7.8 12.1 3.0 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Pyr_redox_2 PF07992.9 CDI76998.1 - 2.7e-24 86.1 0.0 3.8e-23 82.4 0.0 3.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 CDI76998.1 - 1.4e-23 83.0 0.6 9.5e-23 80.3 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 CDI76998.1 - 7.4e-16 58.3 1.3 1.1e-15 57.8 0.0 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 CDI76998.1 - 2.2e-05 24.1 0.6 0.00055 19.6 0.0 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 CDI76998.1 - 7e-05 22.0 0.4 0.0014 17.7 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 CDI76998.1 - 0.00047 19.7 5.9 0.018 14.5 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.9 CDI76998.1 - 0.0015 17.9 0.2 0.0015 17.9 0.1 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.17 CDI76998.1 - 0.0023 16.8 10.0 0.034 13.0 1.4 2.9 3 0 0 3 3 3 2 Glucose inhibited division protein A K_oxygenase PF13434.1 CDI76998.1 - 0.012 14.6 0.2 0.15 10.9 0.1 2.2 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 CDI76998.1 - 0.012 14.5 12.3 0.18 10.6 0.7 3.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase ApbE PF02424.10 CDI76998.1 - 0.21 10.8 8.6 9.2 5.4 0.0 3.4 2 1 1 3 3 3 0 ApbE family Pyr_redox_3 PF13738.1 CDI76998.1 - 6.2 6.8 6.5 0.5 10.3 0.3 2.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase KH_1 PF00013.24 CDI76999.1 - 8.5e-23 79.7 0.0 4.9e-07 29.2 0.0 4.4 4 0 0 4 4 4 3 KH domain KH_3 PF13014.1 CDI76999.1 - 1.8e-12 46.5 0.0 0.0013 18.3 0.0 4.6 4 0 0 4 4 4 3 KH domain Tmemb_9 PF05434.6 CDI76999.1 - 0.028 14.1 3.0 0.045 13.4 2.1 1.3 1 0 0 1 1 1 0 TMEM9 DUF4175 PF13779.1 CDI76999.1 - 0.38 8.4 6.4 0.7 7.5 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Shisa PF13908.1 CDI76999.1 - 3.5 7.7 7.7 9.2 6.4 5.3 1.8 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2244 PF10003.4 CDI76999.1 - 4.5 6.6 9.7 4 6.8 5.4 1.9 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) gpUL132 PF11359.3 CDI76999.1 - 7.5 5.8 7.8 55 2.9 3.9 2.5 2 0 0 2 2 2 0 Glycoprotein UL132 Pkinase PF00069.20 CDI77000.1 - 2.3e-77 259.6 0.0 3.3e-77 259.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77000.1 - 2.8e-37 128.2 0.0 4.1e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.27 CDI77000.1 - 9.6e-11 40.1 4.1 0.00012 21.0 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 CDI77000.1 - 2.6e-09 37.0 1.2 3.2e-06 27.1 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 CDI77000.1 - 1e-06 28.2 2.6 0.017 14.7 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain pair Kinase-like PF14531.1 CDI77000.1 - 7.1e-06 25.1 0.0 1.9e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Kinase-like EF-hand_5 PF13202.1 CDI77000.1 - 0.00013 21.1 0.8 0.21 10.9 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CDI77000.1 - 0.00019 21.0 0.6 0.71 9.9 0.1 3.8 3 0 0 3 3 3 1 EF-hand domain APH PF01636.18 CDI77000.1 - 0.00086 19.1 0.0 0.0022 17.7 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CDI77000.1 - 0.06 12.4 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cas_NE0113 PF09623.5 CDI77001.1 - 0.0059 16.0 0.3 0.015 14.7 0.2 1.6 2 0 0 2 2 2 1 CRISPR-associated protein NE0113 (Cas_NE0113) DUF1875 PF08961.5 CDI77001.1 - 0.031 13.5 9.9 0.11 11.8 0.5 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF1875) TSC22 PF01166.13 CDI77001.1 - 0.11 12.4 0.5 0.11 12.4 0.3 2.5 2 1 0 2 2 2 0 TSC-22/dip/bun family BLOC1_2 PF10046.4 CDI77001.1 - 0.12 12.5 6.8 7.7 6.7 0.2 3.3 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NEMO PF11577.3 CDI77001.1 - 0.16 11.7 0.1 0.16 11.7 0.1 3.1 2 1 0 3 3 3 0 NF-kappa-B essential modulator NEMO Sec8_exocyst PF04048.9 CDI77001.1 - 0.44 10.1 6.2 1 8.9 1.0 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain COG2 PF06148.6 CDI77001.1 - 1.9 8.3 9.8 0.21 11.4 0.7 2.9 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA_13 PF13166.1 CDI77001.1 - 2.3 6.6 8.0 0.69 8.3 1.7 2.0 2 0 0 2 2 2 0 AAA domain HALZ PF02183.13 CDI77001.1 - 3.1 7.6 11.3 1.2 8.8 0.4 3.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper CCDC155 PF14662.1 CDI77001.1 - 3.5 7.1 18.9 0.06 12.9 1.2 2.5 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 DUF904 PF06005.7 CDI77001.1 - 5.5 7.3 15.3 0.28 11.5 0.9 3.7 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Arm PF00514.18 CDI77002.1 - 0.0071 16.1 0.6 0.12 12.2 0.0 2.5 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Cnd1_N PF12922.2 CDI77002.1 - 0.38 10.3 3.1 0.21 11.1 0.4 1.9 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Fes1 PF08609.5 CDI77002.1 - 2.1 8.8 4.5 0.85 10.1 0.2 2.4 3 0 0 3 3 3 0 Nucleotide exchange factor Fes1 UBX PF00789.15 CDI77009.1 - 0.0031 17.5 0.0 0.007 16.3 0.0 1.5 1 0 0 1 1 1 1 UBX domain DUF1675 PF07897.6 CDI77009.1 - 0.64 9.8 6.5 0.87 9.4 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) APG6 PF04111.7 CDI77009.1 - 1 8.3 22.0 1.4 7.8 15.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 RR_TM4-6 PF06459.7 CDI77009.1 - 2.6 7.8 10.0 3.5 7.4 6.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Band_3_cyto PF07565.8 CDI77009.1 - 8.9 5.7 11.3 13 5.1 7.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TPR_1 PF00515.23 CDI77012.1 - 0.04 13.5 1.1 0.064 12.8 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_17 PF13207.1 CDI77013.1 - 5.3e-06 27.2 0.0 1.8e-05 25.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 CDI77013.1 - 0.00027 20.8 0.2 0.00081 19.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CDI77013.1 - 0.00031 20.9 0.0 0.0019 18.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI77013.1 - 0.00045 19.9 0.1 0.00083 19.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CDI77013.1 - 0.001 19.3 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDI77013.1 - 0.0011 19.0 0.0 0.0035 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDI77013.1 - 0.0012 18.4 1.0 0.0012 18.4 0.7 2.9 3 0 0 3 3 2 1 Part of AAA domain Pex14_N PF04695.8 CDI77013.1 - 0.0022 18.0 0.9 0.0022 18.0 0.6 4.5 4 1 1 5 5 5 3 Peroxisomal membrane anchor protein (Pex14p) conserved region Zeta_toxin PF06414.7 CDI77013.1 - 0.0024 17.0 0.1 0.012 14.7 0.1 2.1 2 0 0 2 2 2 1 Zeta toxin 6PF2K PF01591.13 CDI77013.1 - 0.0047 16.0 0.0 0.73 8.8 0.0 2.4 2 0 0 2 2 2 1 6-phosphofructo-2-kinase Mg_chelatase PF01078.16 CDI77013.1 - 0.0078 15.3 0.0 0.023 13.8 0.0 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 CDI77013.1 - 0.0099 14.9 0.0 0.018 14.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus NB-ARC PF00931.17 CDI77013.1 - 0.01 14.7 0.0 0.89 8.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.1 CDI77013.1 - 0.012 15.5 1.9 0.017 15.0 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.1 CDI77013.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CDI77013.1 - 0.027 14.4 0.1 0.074 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 CDI77013.1 - 0.032 14.2 2.5 0.13 12.3 0.1 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.7 CDI77013.1 - 0.054 13.1 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain PAP1 PF08601.5 CDI77013.1 - 0.055 13.1 32.9 0.013 15.2 15.7 2.5 2 0 0 2 2 2 0 Transcription factor PAP1 DNA_pol_B PF00136.16 CDI77016.1 - 1.1e-63 215.7 0.0 1.5e-63 215.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 CDI77016.1 - 1.4e-07 30.6 0.0 2.1e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.8 CDI77016.1 - 0.16 10.5 0.0 6.9 5.2 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral DUF501 PF04417.7 CDI77020.1 - 7.8e-17 61.4 0.8 1.1e-08 35.0 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF501) DUF1115 PF06544.7 CDI77020.1 - 0.49 10.0 4.2 4.7 6.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) DltD_M PF04918.7 CDI77021.1 - 0.094 12.9 2.4 0.16 12.1 1.7 1.3 1 0 0 1 1 1 0 DltD central region RAP PF08373.5 CDI77022.1 - 6.7e-09 35.4 0.1 1.3e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 RAP domain Med15 PF09606.5 CDI77023.1 - 0.39 8.8 74.9 0.17 10.0 7.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI77023.1 - 2.3 5.8 13.5 0.064 10.9 3.4 1.9 2 0 0 2 2 2 0 Ycf1 DUF4175 PF13779.1 CDI77023.1 - 5.4 4.5 52.0 0.086 10.5 24.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Actin PF00022.14 CDI77026.1 - 5.7e-49 166.5 0.1 7.2e-36 123.4 0.2 2.7 2 2 0 2 2 2 2 Actin ERCC4 PF02732.10 CDI77027.1 - 1.4e-16 60.4 1.6 5e-16 58.7 0.0 2.8 3 0 0 3 3 3 1 ERCC4 domain DUF3801 PF12687.2 CDI77027.1 - 0.29 10.7 0.0 0.29 10.7 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3801) SR-25 PF10500.4 CDI77028.1 - 0.0061 16.0 15.0 0.0061 16.0 10.4 4.7 2 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein DUF2956 PF11169.3 CDI77028.1 - 0.018 14.9 3.2 0.018 14.9 2.2 5.1 4 1 1 5 5 5 0 Protein of unknown function (DUF2956) OAD_gamma PF04277.8 CDI77029.1 - 0.0096 16.2 0.3 0.11 12.9 0.0 2.6 3 0 0 3 3 3 1 Oxaloacetate decarboxylase, gamma chain ASF1_hist_chap PF04729.8 CDI77030.1 - 3.9e-60 201.9 0.0 5.3e-60 201.5 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone BCNT PF07572.7 CDI77032.1 - 2.5e-10 40.1 0.2 4.9e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development Rifin_STEVOR PF02009.11 CDI77032.1 - 5.6 6.5 12.3 6.9 6.2 8.5 1.1 1 0 0 1 1 1 0 Rifin/stevor family PRCC PF10253.4 CDI77033.1 - 0.0011 19.6 6.2 0.002 18.8 4.3 1.4 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting DUF605 PF04652.11 CDI77033.1 - 0.22 10.8 15.7 0.27 10.5 10.9 1.2 1 0 0 1 1 1 0 Vta1 like Gon7 PF08738.5 CDI77033.1 - 4.2 7.3 6.4 0.24 11.4 0.2 2.0 2 0 0 2 2 2 0 Gon7 family Macoilin PF09726.4 CDI77033.1 - 9.5 4.3 7.3 10 4.2 5.1 1.2 1 0 0 1 1 1 0 Transmembrane protein AAA_9 PF12781.2 CDI77035.1 - 3.6e-12 45.6 0.5 3.6e-12 45.6 0.3 1.6 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 IER PF05760.7 CDI77035.1 - 0.01 15.8 12.7 0.022 14.7 8.8 1.5 1 0 0 1 1 1 1 Immediate early response protein (IER) DUF2573 PF10835.3 CDI77035.1 - 0.15 12.1 1.7 2.9 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2573) FAP PF07174.6 CDI77035.1 - 3.4 6.8 23.0 5.4 6.2 16.0 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) SR-25 PF10500.4 CDI77035.1 - 6.4 6.1 10.7 1.4 8.2 0.8 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CemA PF03040.9 CDI77035.1 - 9.2 5.7 7.8 25 4.3 3.1 2.3 2 0 0 2 2 2 0 CemA family PEPCK_ATP PF01293.15 CDI77036.1 - 1.9e-154 514.6 0.0 2.2e-154 514.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_29 PF13555.1 CDI77036.1 - 0.039 13.4 0.3 0.083 12.4 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 CDI77036.1 - 0.045 13.6 0.0 0.084 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CDI77036.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 CDI77036.1 - 0.1 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.1 CDI77036.1 - 0.15 10.4 0.0 0.21 10.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain ChaC PF04752.7 CDI77038.1 - 3.7 7.4 6.1 0.97 9.3 0.5 2.5 2 1 0 2 2 2 0 ChaC-like protein AAA PF00004.24 CDI77040.1 - 0.35 11.0 0.0 0.73 10.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RRM_1 PF00076.17 CDI77046.1 - 2.7e-32 110.2 0.9 7.5e-17 60.7 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI77046.1 - 1e-28 99.0 0.1 2.6e-13 49.7 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI77046.1 - 2.6e-10 39.9 0.1 6.5e-06 25.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ChAPs PF09295.5 CDI77048.1 - 9.3e-23 80.6 0.0 9.3e-23 80.6 0.0 2.9 3 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) DUF2763 PF10961.3 CDI77051.1 - 6 7.3 7.0 2 8.8 2.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) SPRR2 PF14820.1 CDI77051.1 - 9.9 6.1 10.5 0.21 11.4 1.9 2.2 2 0 0 2 2 2 0 Small proline-rich 2 Ribosomal_60s PF00428.14 CDI77053.1 - 0.013 15.8 4.3 0.013 15.8 3.0 8.9 7 2 0 7 7 7 0 60s Acidic ribosomal protein Ribosomal_L1 PF00687.16 CDI77053.1 - 0.14 11.4 0.0 0.41 9.9 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L1p/L10e family YajC PF02699.10 CDI77054.1 - 0.89 9.2 2.5 1.5 8.5 1.7 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit RRM_1 PF00076.17 CDI77055.1 - 0.017 14.7 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.4 CDI77055.1 - 0.25 9.5 4.5 0.38 8.9 3.1 1.3 1 0 0 1 1 1 0 Transmembrane protein Pheromone PF08015.6 CDI77055.1 - 0.37 11.6 7.1 0.27 12.1 1.5 3.3 3 0 0 3 3 3 0 Fungal mating-type pheromone LAG1-DNAbind PF09271.6 CDI77056.1 - 2.2 8.7 12.1 0.15 12.4 0.5 2.8 3 0 0 3 3 3 0 LAG1, DNA binding Peptidase_S64 PF08192.6 CDI77056.1 - 3.3 5.9 15.8 5.4 5.2 10.9 1.3 1 0 0 1 1 1 0 Peptidase family S64 DUF2347 PF09804.4 CDI77056.1 - 3.9 6.6 7.7 2.5 7.2 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) LSM PF01423.17 CDI77057.1 - 0.00027 20.4 0.1 0.00039 19.9 0.1 1.2 1 0 0 1 1 1 1 LSM domain DAGK_acc PF00609.14 CDI77058.1 - 4.4e-18 65.9 0.0 6.4e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 CDI77058.1 - 0.00015 21.1 0.0 0.00027 20.3 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Bul1_N PF04425.7 CDI77059.1 - 1.6 7.1 8.3 2.2 6.7 5.7 1.0 1 0 0 1 1 1 0 Bul1 N terminus Presenilin PF01080.12 CDI77059.1 - 6.9 5.3 7.3 10 4.8 5.1 1.2 1 0 0 1 1 1 0 Presenilin MDFI PF15316.1 CDI77059.1 - 9.2 6.2 7.7 8.3 6.3 3.8 1.9 2 0 0 2 2 2 0 MyoD family inhibitor MFS_1 PF07690.11 CDI77061.1 - 1.5e-14 53.4 16.6 1.5e-14 53.4 11.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDI77061.1 - 0.0046 15.5 0.0 0.0046 15.5 0.0 2.6 2 0 0 2 2 2 1 Sugar (and other) transporter Med15 PF09606.5 CDI77061.1 - 0.8 7.8 15.7 0.3 9.2 3.9 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal APC_CDC26 PF10471.4 CDI77061.1 - 4.6 8.0 13.5 5.8 7.7 1.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 DUF31 PF01732.11 CDI77062.1 - 0.0063 15.8 7.4 0.0033 16.8 3.3 1.9 1 1 1 2 2 2 1 Putative peptidase (DUF31) Activator_LAG-3 PF11498.3 CDI77063.1 - 0.027 13.2 54.5 0.02 13.6 16.6 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 CAF-1_p150 PF11600.3 CDI77063.1 - 0.045 13.1 56.8 0.01 15.2 30.8 2.4 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CDC27 PF09507.5 CDI77063.1 - 0.09 11.9 42.6 0.025 13.8 24.5 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Herpes_UL4 PF03277.8 CDI77063.1 - 0.12 11.6 9.4 0.28 10.4 2.3 2.4 2 0 0 2 2 2 0 Herpesvirus UL4 family Band_3_cyto PF07565.8 CDI77063.1 - 1.1 8.7 18.9 7 6.0 0.2 2.4 2 0 0 2 2 2 0 Band 3 cytoplasmic domain AAA_11 PF13086.1 CDI77063.1 - 1.7 8.1 23.0 8.5 5.8 11.8 2.3 2 0 0 2 2 2 0 AAA domain PAT1 PF09770.4 CDI77063.1 - 1.9 6.6 68.9 2.1 6.4 19.9 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI77063.1 - 2 8.2 55.1 0.099 12.5 20.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PRP38_assoc PF12871.2 CDI77063.1 - 3.4 8.2 38.8 1.8 9.1 17.2 2.6 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Spore_coat_CotO PF14153.1 CDI77063.1 - 6.8 6.0 40.1 1.1 8.6 0.4 2.5 2 0 0 2 2 2 0 Spore coat protein CotO Otopetrin PF03189.8 CDI77063.1 - 7.7 5.3 7.1 4.6 6.1 1.9 2.0 2 0 0 2 2 2 0 Otopetrin Pkinase PF00069.20 CDI77065.1 - 0.00032 19.9 0.0 0.00032 19.9 0.0 2.1 2 1 0 2 2 1 1 Protein kinase domain eIF3_subunit PF08597.5 CDI77065.1 - 0.012 15.1 14.4 0.016 14.7 10.0 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Borrelia_P83 PF05262.6 CDI77065.1 - 0.15 10.2 16.0 0.19 9.9 11.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Spore_coat_CotO PF14153.1 CDI77065.1 - 0.18 11.2 13.1 0.2 11.0 9.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Ycf1 PF05758.7 CDI77065.1 - 0.21 9.2 7.1 0.22 9.1 4.9 1.0 1 0 0 1 1 1 0 Ycf1 Menin PF05053.8 CDI77065.1 - 0.4 8.7 3.3 0.47 8.5 2.3 1.0 1 0 0 1 1 1 0 Menin DDRGK PF09756.4 CDI77065.1 - 0.48 9.7 20.1 0.62 9.4 13.9 1.1 1 0 0 1 1 1 0 DDRGK domain Bud13 PF09736.4 CDI77065.1 - 0.87 9.8 16.5 1.3 9.2 11.5 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Med15 PF09606.5 CDI77065.1 - 0.99 7.5 30.7 1.2 7.2 21.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Dicty_REP PF05086.7 CDI77065.1 - 2 6.0 5.4 2.3 5.8 3.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Neur_chan_memb PF02932.11 CDI77065.1 - 2.5 7.9 6.6 2.9 7.7 4.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AvrE PF11725.3 CDI77065.1 - 2.6 4.9 14.9 3.1 4.6 10.3 1.0 1 0 0 1 1 1 0 Pathogenicity factor DUF4220 PF13968.1 CDI77065.1 - 3.6 6.5 4.8 4.3 6.3 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Activator_LAG-3 PF11498.3 CDI77065.1 - 4 6.0 34.1 5.1 5.7 23.6 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF1510 PF07423.6 CDI77065.1 - 4.4 6.6 15.6 5.7 6.2 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PAT1 PF09770.4 CDI77065.1 - 4.5 5.3 23.0 5.2 5.1 16.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.9 CDI77065.1 - 8.3 4.2 12.6 9.4 4.1 8.8 1.0 1 0 0 1 1 1 0 CDC45-like protein SOBP PF15279.1 CDI77065.1 - 8.7 6.6 10.3 10 6.3 7.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Spore_YhcN_YlaJ PF09580.5 CDI77065.1 - 9.4 6.3 12.7 12 5.9 8.8 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF4638 PF15472.1 CDI77065.1 - 9.5 5.7 13.6 13 5.2 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) NPR3 PF03666.8 CDI77065.1 - 9.7 4.5 12.4 12 4.2 8.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 OmpH PF03938.9 CDI77067.1 - 0.0013 18.7 14.2 0.0019 18.1 9.9 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) HEAT_EZ PF13513.1 CDI77068.1 - 1e-14 54.4 23.0 7.1e-06 26.3 0.1 10.2 7 2 2 9 9 9 4 HEAT-like repeat HEAT PF02985.17 CDI77068.1 - 2.2e-07 30.3 16.9 0.00083 19.2 0.0 7.5 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.1 CDI77068.1 - 1.2e-05 25.4 26.3 0.1 12.9 0.0 7.7 6 2 2 8 8 8 4 HEAT repeats Tim44 PF04280.10 CDI77069.1 - 1.1e-11 44.9 0.0 1.1e-11 44.9 0.0 2.0 2 0 0 2 2 2 1 Tim44-like domain RRM_1 PF00076.17 CDI77071.1 - 4.2e-13 48.7 0.0 1.3e-12 47.1 0.0 1.7 1 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI77071.1 - 1.6e-10 40.7 0.0 2.6e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI77071.1 - 0.085 12.7 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Vps54 PF07928.7 CDI77072.1 - 4.2e-11 43.1 1.1 4.2e-11 43.1 0.8 2.5 2 0 0 2 2 2 1 Vps54-like protein Ribosomal_60s PF00428.14 CDI77073.1 - 0.039 14.3 6.2 0.094 13.1 4.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ank_4 PF13637.1 CDI77075.1 - 3.3e-09 37.0 0.1 2.8e-05 24.5 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI77075.1 - 5.5e-09 36.2 1.2 7.5e-09 35.8 0.1 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 CDI77075.1 - 2.3e-08 33.4 0.0 3.2e-06 26.6 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 CDI77075.1 - 6.9e-07 29.3 0.1 2.1e-06 27.8 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI77075.1 - 6.2e-05 22.8 0.0 0.0014 18.6 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Bromodomain PF00439.20 CDI77075.1 - 0.049 13.5 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain BOP1NT PF08145.7 CDI77078.1 - 1.5e-45 155.9 3.8 1.5e-45 155.9 2.6 1.7 2 0 0 2 2 2 1 BOP1NT (NUC169) domain DUF4533 PF15047.1 CDI77078.1 - 0.026 13.9 1.3 0.041 13.3 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) FimH_man-bind PF09160.5 CDI77078.1 - 0.072 12.9 0.1 0.47 10.2 0.0 2.0 2 0 0 2 2 2 0 FimH, mannose binding CAF-1_p150 PF11600.3 CDI77078.1 - 0.09 12.1 5.5 0.18 11.1 3.8 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Suf PF05843.9 CDI77078.1 - 1.5 8.5 7.6 2.9 7.5 5.3 1.6 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) SR-25 PF10500.4 CDI77078.1 - 2.5 7.5 13.4 0.72 9.2 6.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1510 PF07423.6 CDI77079.1 - 0.04 13.2 26.4 0.046 13.0 18.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3807 PF12720.2 CDI77079.1 - 0.79 9.8 30.6 0.94 9.6 21.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Draxin PF15550.1 CDI77079.1 - 0.86 9.1 20.9 0.95 9.0 14.5 1.0 1 0 0 1 1 1 0 Draxin Rtf2 PF04641.7 CDI77079.1 - 1.7 7.8 25.8 2 7.5 17.9 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2201_N PF13203.1 CDI77079.1 - 1.7 7.7 29.4 1.9 7.6 20.4 1.0 1 0 0 1 1 1 0 Putative metallopeptidase domain Otopetrin PF03189.8 CDI77079.1 - 2.4 7.0 13.9 2.8 6.8 9.6 1.1 1 0 0 1 1 1 0 Otopetrin Herpes_DNAp_acc PF04929.7 CDI77079.1 - 2.8 6.7 20.9 3.1 6.6 14.5 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Zip PF02535.17 CDI77079.1 - 2.9 6.8 13.7 3.5 6.5 9.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.1 CDI77079.1 - 3.3 6.1 23.2 3.6 5.9 16.1 1.0 1 0 0 1 1 1 0 Raftlin DUF2052 PF09747.4 CDI77079.1 - 4 7.3 29.9 5.5 6.8 20.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FNIP_N PF14636.1 CDI77079.1 - 4.8 7.6 21.6 6.4 7.2 15.0 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus Neur_chan_memb PF02932.11 CDI77079.1 - 5.1 6.9 22.3 5.2 6.8 15.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CKAP2_C PF15297.1 CDI77079.1 - 5.5 5.6 24.5 6.7 5.4 17.0 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF4638 PF15472.1 CDI77079.1 - 6.3 6.3 22.2 7.8 5.9 15.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF4045 PF13254.1 CDI77079.1 - 7.7 5.6 22.8 8.5 5.5 15.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Vfa1 PF08432.5 CDI77079.1 - 9.7 6.1 27.5 12 5.8 19.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 eIF-1a PF01176.14 CDI77080.1 - 1.7e-09 36.9 0.4 2.4e-09 36.5 0.3 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Serglycin PF04360.7 CDI77080.1 - 0.041 13.6 0.6 0.051 13.3 0.4 1.2 1 0 0 1 1 1 0 Serglycin Methyltransf_15 PF09445.5 CDI77080.1 - 0.33 10.5 2.1 0.52 9.8 1.4 1.5 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase FxsA PF04186.8 CDI77080.1 - 0.98 9.0 4.1 1.6 8.3 2.9 1.3 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein CAF-1_p150 PF11600.3 CDI77084.1 - 8.3e-05 22.0 19.4 8.3e-05 22.0 13.5 6.8 7 1 0 7 7 7 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal RabGAP-TBC PF00566.13 CDI77084.1 - 0.0082 15.6 0.0 0.0082 15.6 0.0 5.9 6 0 0 6 6 6 1 Rab-GTPase-TBC domain Gly-zipper_OmpA PF13436.1 CDI77087.1 - 0.012 15.3 1.6 0.013 15.1 1.1 1.1 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Chorion_2 PF03964.10 CDI77087.1 - 0.049 14.1 5.0 0.055 14.0 3.5 1.1 1 0 0 1 1 1 0 Chorion family 2 Ribosomal_60s PF00428.14 CDI77087.1 - 0.069 13.5 5.5 0.075 13.4 3.8 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein TALPID3 PF15324.1 CDI77087.1 - 0.5 7.6 3.6 0.48 7.7 2.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target CDK2AP PF09806.4 CDI77087.1 - 0.74 10.0 5.2 0.75 9.9 3.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein MSA-2c PF12238.3 CDI77087.1 - 0.79 9.3 5.8 0.83 9.2 4.0 1.0 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF3138 PF11336.3 CDI77087.1 - 3.8 5.5 6.9 4.1 5.4 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF2360 PF10152.4 CDI77087.1 - 4.4 7.5 7.9 5.2 7.3 5.4 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Dicty_REP PF05086.7 CDI77088.1 - 0.67 7.6 9.6 1 7.0 6.6 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SRP54 PF00448.17 CDI77089.1 - 5.7e-75 251.0 0.2 1.2e-74 250.0 0.0 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 CDI77089.1 - 2.1e-28 98.6 0.3 2.1e-28 98.6 0.2 3.0 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.14 CDI77089.1 - 2.9e-09 36.8 0.8 6.2e-08 32.6 0.1 3.0 3 0 0 3 3 2 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.1 CDI77089.1 - 1.9e-07 31.0 0.0 4.3e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.14 CDI77089.1 - 1.6e-06 27.7 0.4 1.3e-05 24.7 0.0 2.6 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CDI77089.1 - 2.2e-05 24.1 0.0 5.9e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 CDI77089.1 - 5.2e-05 23.3 0.1 0.0006 19.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain CbiA PF01656.18 CDI77089.1 - 0.00036 19.9 0.0 0.0014 18.0 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CDI77089.1 - 0.0013 18.6 0.1 1.1 9.1 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.1 CDI77089.1 - 0.0027 17.3 0.0 0.0091 15.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.5 CDI77089.1 - 0.003 16.7 1.8 0.69 9.0 0.0 2.7 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit AAA_17 PF13207.1 CDI77089.1 - 0.0046 17.7 0.0 0.0095 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDI77089.1 - 0.0054 15.8 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.1 CDI77089.1 - 0.006 16.5 0.0 0.016 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain DUF4310 PF14187.1 CDI77089.1 - 0.0097 15.4 0.5 0.019 14.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4310) Pol_alpha_B_N PF08418.5 CDI77089.1 - 0.012 15.1 0.6 0.026 14.0 0.1 1.7 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Methyltransf_24 PF13578.1 CDI77089.1 - 0.02 15.6 0.0 0.05 14.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain APS_kinase PF01583.15 CDI77089.1 - 0.032 13.9 0.0 0.065 12.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF2209 PF09974.4 CDI77089.1 - 0.11 12.5 0.3 0.28 11.2 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) SR-25 PF10500.4 CDI77089.1 - 0.32 10.4 10.6 0.64 9.4 7.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.6 CDI77089.1 - 0.45 8.5 2.8 0.65 8.0 1.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Herpes_capsid PF06112.6 CDI77089.1 - 1.8 8.6 8.8 4.3 7.3 6.1 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Spt20 PF12090.3 CDI77090.1 - 0.98 8.7 9.7 6 6.1 3.3 2.3 2 0 0 2 2 2 0 Spt20 family LMBR1 PF04791.11 CDI77090.1 - 1.8 7.0 4.0 0.67 8.4 0.7 1.6 1 1 1 2 2 2 0 LMBR1-like membrane protein Brix PF04427.13 CDI77091.1 - 1.1e-08 35.0 6.9 5.1e-08 32.7 4.8 2.0 1 1 0 1 1 1 1 Brix domain Med15 PF09606.5 CDI77091.1 - 5.7 5.0 69.4 1.8 6.6 16.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Collagen PF01391.13 CDI77093.1 - 4.9e-05 22.7 48.6 4.9e-05 22.7 33.7 2.2 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) PIH1 PF08190.7 CDI77094.1 - 0.00096 18.6 12.6 0.0047 16.4 9.5 1.5 2 0 0 2 2 2 1 pre-RNA processing PIH1/Nop17 Ycf1 PF05758.7 CDI77094.1 - 0.45 8.1 5.2 0.52 7.9 3.6 1.1 1 0 0 1 1 1 0 Ycf1 Polyoma_coat2 PF00761.15 CDI77094.1 - 0.64 9.4 8.7 6.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Polyomavirus coat protein AAA_23 PF13476.1 CDI77094.1 - 1 9.6 8.4 1.9 8.7 5.8 1.4 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.4 CDI77094.1 - 1.4 7.0 32.2 1.7 6.8 22.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.9 CDI77094.1 - 1.5 8.5 11.0 2.1 8.0 7.6 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CDC45 PF02724.9 CDI77094.1 - 2.5 6.0 7.9 3.1 5.6 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4175 PF13779.1 CDI77094.1 - 3.5 5.1 24.6 4 5.0 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Hid1 PF12722.2 CDI77094.1 - 4.2 4.9 9.9 4.8 4.7 6.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CPSF100_C PF13299.1 CDI77094.1 - 5 7.2 8.0 20 5.3 6.0 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1675 PF07897.6 CDI77094.1 - 5.1 6.8 8.9 7.9 6.2 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Abhydrolase_5 PF12695.2 CDI77096.1 - 1.3e-09 37.9 17.3 2.8e-06 27.1 0.6 3.5 2 1 1 3 3 3 2 Alpha/beta hydrolase family DUF411 PF04214.8 CDI77096.1 - 0.002 17.5 0.0 4.6 6.8 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function, DUF LMBR1 PF04791.11 CDI77096.1 - 0.36 9.3 4.1 4.2 5.8 0.4 2.1 1 1 1 2 2 2 0 LMBR1-like membrane protein Tetraspannin PF00335.15 CDI77096.1 - 3.2 6.9 9.8 0.62 9.2 2.3 2.4 2 0 0 2 2 2 0 Tetraspanin family HOOK PF05622.7 CDI77097.1 - 2e-05 22.6 25.4 2e-05 22.6 17.6 2.2 3 0 0 3 3 3 1 HOOK protein FlxA PF14282.1 CDI77097.1 - 0.011 15.7 16.5 0.011 15.7 11.4 6.1 6 1 0 6 6 6 0 FlxA-like protein Dehydrin PF00257.14 CDI77097.1 - 0.023 15.0 0.3 0.023 15.0 0.2 4.2 3 1 0 3 3 3 0 Dehydrin NPV_P10 PF05531.7 CDI77097.1 - 8.3 6.7 16.6 0.6 10.4 0.4 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Helicase_C PF00271.26 CDI77098.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Helicase conserved C-terminal domain SR-25 PF10500.4 CDI77099.1 - 0.0037 16.7 4.8 0.0037 16.7 3.3 4.6 5 1 0 5 5 5 1 Nuclear RNA-splicing-associated protein HGTP_anticodon2 PF12745.2 CDI77100.1 - 0.47 9.5 10.6 0.53 9.3 7.3 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs MDFI PF15316.1 CDI77100.1 - 3.1 7.7 11.1 3.8 7.4 7.7 1.1 1 0 0 1 1 1 0 MyoD family inhibitor DUF1266 PF06889.6 CDI77101.1 - 3.2 7.5 24.8 1.4 8.6 6.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) Ycf1 PF05758.7 CDI77101.1 - 3.4 5.2 22.2 0.58 7.8 4.8 2.2 2 0 0 2 2 2 0 Ycf1 RRM_1 PF00076.17 CDI77102.1 - 7.5e-40 134.4 0.0 2.9e-11 42.8 0.0 6.7 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI77102.1 - 1.4e-36 124.2 0.0 3.7e-08 33.2 0.0 6.7 6 1 0 6 6 6 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI77102.1 - 1.5e-24 85.5 0.2 1.4e-06 28.0 0.0 5.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 CDI77102.1 - 3.6e-10 39.4 7.2 2.3e-08 33.4 0.0 5.4 5 0 0 5 5 5 1 Protein kinase domain Sec3_C PF09763.4 CDI77103.1 - 1.1 7.3 6.4 1.2 7.1 4.5 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 Hid1 PF12722.2 CDI77103.1 - 2.9 5.4 6.8 3.1 5.3 4.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RAP1 PF07218.6 CDI77103.1 - 8.2 4.3 7.8 9.9 4.1 5.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDC45 PF02724.9 CDI77103.1 - 9.9 4.0 11.3 11 3.8 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DctM PF06808.7 CDI77104.1 - 0.00029 19.5 1.1 0.00048 18.8 0.8 1.2 1 0 0 1 1 1 1 DctM-like transporters O-antigen_lig PF13425.1 CDI77104.1 - 0.0036 17.2 1.0 0.0068 16.3 0.7 1.4 1 0 0 1 1 1 1 O-antigen ligase like membrane protein PT PF04886.7 CDI77104.1 - 0.0041 16.3 29.2 0.025 13.8 16.5 2.9 2 1 0 2 2 2 1 PT repeat DoxX_3 PF13781.1 CDI77104.1 - 0.05 13.9 1.9 0.13 12.5 1.3 1.7 1 0 0 1 1 1 0 DoxX-like family FUSC_2 PF13515.1 CDI77104.1 - 0.17 11.8 5.9 0.38 10.6 4.1 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein-like DUF4131 PF13567.1 CDI77104.1 - 0.62 9.4 4.1 0.77 9.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2217 PF10265.4 CDI77104.1 - 0.79 8.4 5.5 1.1 7.9 3.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF4448 PF14610.1 CDI77106.1 - 0.87 9.0 4.2 1.9 7.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4448) FimP PF09766.4 CDI77106.1 - 7.3 5.5 59.4 0.015 14.3 4.2 4.5 5 0 0 5 5 5 0 Fms-interacting protein BAF1_ABF1 PF04684.8 CDI77107.1 - 4.9e-05 22.3 24.4 4.9e-05 22.3 16.9 2.7 2 1 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor GFP PF01353.17 CDI77107.1 - 0.1 11.9 6.4 0.16 11.2 4.5 1.2 1 0 0 1 1 1 0 Green fluorescent protein DUF2365 PF10157.4 CDI77107.1 - 1.1 9.1 7.8 0.059 13.2 1.6 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2365) NAC PF01849.13 CDI77108.1 - 2.4e-16 58.9 0.0 5e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 NAC domain PGM_PMM_II PF02879.11 CDI77108.1 - 0.0051 17.1 0.7 2.7 8.3 0.1 2.1 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II EBV-NA3 PF05009.7 CDI77108.1 - 0.036 13.3 0.1 0.046 12.9 0.1 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF755 PF05501.6 CDI77110.1 - 0.023 14.7 31.7 0.023 14.7 21.9 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF755) Clat_adaptor_s PF01217.15 CDI77111.1 - 7.5e-47 158.6 1.8 7.2e-45 152.1 1.3 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain CDC45 PF02724.9 CDI77117.1 - 0.0031 15.6 16.0 0.0031 15.6 11.1 2.3 2 0 0 2 2 2 1 CDC45-like protein Snapin_Pallidin PF14712.1 CDI77117.1 - 0.0043 17.3 0.4 0.016 15.5 0.3 1.9 1 0 0 1 1 1 1 Snapin/Pallidin BSP_II PF05432.6 CDI77117.1 - 8.7 5.5 44.8 2 7.6 17.2 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) DHHW PF14286.1 CDI77117.1 - 8.9 5.5 22.4 1.7 7.8 5.9 2.2 2 0 0 2 2 2 0 DHHW protein Kringle PF00051.13 CDI77118.1 - 3.3e-11 43.1 3.7 7.6e-11 41.9 2.6 1.6 1 0 0 1 1 1 1 Kringle domain MAR_sialic_bdg PF10564.4 CDI77118.1 - 6.6e-05 22.6 1.7 0.015 15.0 0.2 2.5 1 1 1 2 2 2 2 Sialic-acid binding micronemal adhesive repeat PDCD2_C PF04194.8 CDI77119.1 - 1.6e-05 24.5 0.0 1.6e-05 24.5 0.0 3.3 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain DUF677 PF05055.7 CDI77119.1 - 0.51 8.9 3.9 1.2 7.7 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF677) FAM176 PF14851.1 CDI77119.1 - 3.2 7.4 8.2 0.59 9.7 2.0 2.1 2 0 0 2 2 2 0 FAM176 family Arc_trans_TRASH PF08394.5 CDI77119.1 - 8.2 6.6 10.4 0.15 12.2 0.4 2.5 2 0 0 2 2 2 0 Archaeal TRASH domain SDA1 PF05285.7 CDI77120.1 - 2.2e-31 109.3 26.3 2.2e-31 109.3 18.2 3.4 2 1 1 3 3 3 1 SDA1 NUC130_3NT PF08158.7 CDI77120.1 - 0.0063 16.7 7.3 0.15 12.3 0.2 4.3 4 0 0 4 4 4 2 NUC130/3NT domain Cyt-b5 PF00173.23 CDI77121.1 - 4.5e-17 61.6 0.0 7.1e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CAF-1_p150 PF11600.3 CDI77121.1 - 2 7.7 11.3 3.1 7.1 7.8 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Suf PF05843.9 CDI77121.1 - 2.1 8.0 5.1 2.5 7.7 3.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Corona_nucleoca PF00937.13 CDI77121.1 - 3 6.7 12.6 3.9 6.3 8.7 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF605 PF04652.11 CDI77121.1 - 3.8 6.8 15.6 4.6 6.5 10.8 1.1 1 0 0 1 1 1 0 Vta1 like Apt1 PF10351.4 CDI77121.1 - 4.5 6.0 6.9 5.6 5.6 4.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DSPc PF00782.15 CDI77122.1 - 1.4e-16 60.3 0.0 3.1e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDI77122.1 - 0.051 12.9 0.0 0.093 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase EI24 PF07264.6 CDI77123.1 - 0.01 15.3 0.9 0.18 11.2 0.5 1.9 1 1 1 2 2 2 2 Etoposide-induced protein 2.4 (EI24) DUF1625 PF07787.7 CDI77123.1 - 0.04 13.1 0.1 0.065 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1625) NfeD PF01957.13 CDI77123.1 - 0.075 13.1 0.2 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF747 PF05346.6 CDI77123.1 - 0.085 11.8 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic membrane protein family HemY_N PF07219.8 CDI77123.1 - 0.095 12.2 0.7 4.9 6.7 0.0 2.5 2 0 0 2 2 2 0 HemY protein N-terminus Tmemb_18A PF09771.4 CDI77123.1 - 0.097 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 188 DUF4149 PF13664.1 CDI77123.1 - 0.14 12.2 0.3 0.14 12.2 0.2 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) DUF1427 PF07235.6 CDI77123.1 - 0.15 12.1 0.9 0.47 10.5 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1427) Tom37_C PF11801.3 CDI77123.1 - 0.42 10.4 4.8 1.4 8.7 0.2 2.2 2 0 0 2 2 2 0 Tom37 C-terminal domain OPA3 PF07047.7 CDI77123.1 - 1.2 8.9 5.7 0.17 11.6 0.3 1.9 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) DUF4199 PF13858.1 CDI77123.1 - 2.1 8.2 5.5 1.3 8.9 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) TMEM51 PF15345.1 CDI77123.1 - 3.1 7.4 7.5 0.34 10.5 0.7 2.1 2 1 0 2 2 2 0 Transmembrane protein 51 OmpH PF03938.9 CDI77123.1 - 4 7.3 24.0 1.2 9.0 2.9 2.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Activator_LAG-3 PF11498.3 CDI77126.1 - 0.023 13.4 13.1 0.036 12.8 9.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4175 PF13779.1 CDI77126.1 - 1.8 6.1 10.6 2.1 5.9 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Med3 PF11593.3 CDI77126.1 - 2.6 7.1 9.8 3.6 6.7 6.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF663 PF04950.7 CDI77129.1 - 8.9e-43 146.3 0.1 8.9e-43 146.3 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF663) Glyco_hydro_4 PF02056.11 CDI77129.1 - 0.012 14.9 0.0 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase DNA_pol_A_exo1 PF01612.15 CDI77135.1 - 1e-11 44.6 1.0 9.1e-11 41.5 0.1 2.1 2 0 0 2 2 2 1 3'-5' exonuclease DUF3316 PF11777.3 CDI77135.1 - 0.014 15.1 0.8 0.068 12.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3316) HCO3_cotransp PF00955.16 CDI77136.1 - 0.00025 19.8 2.2 0.00032 19.4 1.5 1.1 1 0 0 1 1 1 1 HCO3- transporter family Spore_coat_CotO PF14153.1 CDI77136.1 - 0.0018 17.7 24.4 0.0022 17.4 16.9 1.2 1 0 0 1 1 1 1 Spore coat protein CotO TFIIA PF03153.8 CDI77136.1 - 0.0024 17.8 31.7 0.0027 17.6 22.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI77136.1 - 0.0025 16.1 50.0 0.0027 16.0 34.6 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 FLO_LFY PF01698.11 CDI77136.1 - 0.0034 16.2 16.6 0.0041 16.0 11.5 1.1 1 0 0 1 1 1 1 Floricaula / Leafy protein Zip PF02535.17 CDI77136.1 - 0.017 14.1 13.5 0.021 13.8 9.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.1 CDI77136.1 - 0.025 14.3 15.6 0.034 13.9 10.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A LMBR1 PF04791.11 CDI77136.1 - 0.066 11.7 7.0 0.096 11.2 4.7 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.2 CDI77136.1 - 0.066 10.8 21.7 0.078 10.6 15.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4045 PF13254.1 CDI77136.1 - 0.068 12.4 17.8 0.078 12.2 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Parvo_coat PF00740.13 CDI77136.1 - 0.085 11.7 21.1 0.099 11.5 14.6 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 CDC45 PF02724.9 CDI77136.1 - 0.092 10.7 18.6 0.11 10.5 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.1 CDI77136.1 - 0.11 11.0 18.4 0.13 10.7 12.7 1.1 1 0 0 1 1 1 0 Raftlin SprA-related PF12118.3 CDI77136.1 - 0.12 11.6 46.9 0.17 11.1 32.5 1.2 1 0 0 1 1 1 0 SprA-related family SPX PF03105.14 CDI77136.1 - 0.14 11.8 18.6 0.18 11.5 12.9 1.2 1 0 0 1 1 1 0 SPX domain Ycf1 PF05758.7 CDI77136.1 - 0.16 9.6 19.4 0.18 9.4 13.5 1.1 1 0 0 1 1 1 0 Ycf1 NPR3 PF03666.8 CDI77136.1 - 0.24 9.8 18.8 0.31 9.5 13.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2370 PF10176.4 CDI77136.1 - 0.29 10.4 12.3 0.48 9.7 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) CDK5_activator PF03261.10 CDI77136.1 - 0.29 10.4 17.4 0.45 9.7 12.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Neur_chan_memb PF02932.11 CDI77136.1 - 0.31 10.8 19.1 0.42 10.4 13.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FemAB PF02388.11 CDI77136.1 - 0.32 9.6 19.7 0.44 9.1 13.6 1.2 1 0 0 1 1 1 0 FemAB family PCEMA1 PF07418.6 CDI77136.1 - 0.35 10.1 12.6 0.46 9.8 8.8 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 AvrE PF11725.3 CDI77136.1 - 0.47 7.4 21.6 0.5 7.3 15.0 1.0 1 0 0 1 1 1 0 Pathogenicity factor DUF2201_N PF13203.1 CDI77136.1 - 0.5 9.5 25.0 0.71 8.9 17.3 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Exonuc_VII_L PF02601.10 CDI77136.1 - 0.64 9.1 19.2 0.75 8.9 13.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit GPCR_chapero_1 PF11904.3 CDI77136.1 - 0.64 9.0 20.6 0.82 8.7 14.3 1.1 1 0 0 1 1 1 0 GPCR-chaperone DUF4220 PF13968.1 CDI77136.1 - 0.65 9.0 11.8 0.87 8.6 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Glyco_transf_15 PF01793.11 CDI77136.1 - 0.74 8.7 17.9 0.59 9.0 11.3 1.6 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase Otopetrin PF03189.8 CDI77136.1 - 0.81 8.6 11.1 1.1 8.1 7.7 1.2 1 0 0 1 1 1 0 Otopetrin Ndc1_Nup PF09531.5 CDI77136.1 - 0.83 7.9 13.7 0.92 7.8 9.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SAPS PF04499.10 CDI77136.1 - 0.84 8.1 19.1 1.1 7.7 13.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein OmpH PF03938.9 CDI77136.1 - 0.92 9.4 44.8 1.7 8.5 31.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF605 PF04652.11 CDI77136.1 - 1.4 8.2 27.2 1.8 7.8 18.8 1.2 1 0 0 1 1 1 0 Vta1 like Paramyxo_ncap PF00973.14 CDI77136.1 - 1.8 7.1 17.1 2.1 6.9 11.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FliP PF00813.15 CDI77136.1 - 1.8 8.1 7.5 2.7 7.6 5.2 1.4 1 0 0 1 1 1 0 FliP family AUX_IAA PF02309.11 CDI77136.1 - 1.9 8.1 19.1 3.2 7.4 13.2 1.4 1 0 0 1 1 1 0 AUX/IAA family eIF-3_zeta PF05091.7 CDI77136.1 - 2 6.9 32.6 2.6 6.5 22.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Med15 PF09606.5 CDI77136.1 - 3.1 5.8 75.8 3.7 5.6 52.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CRT10 PF08728.5 CDI77136.1 - 3.2 5.6 16.8 3.7 5.4 11.6 1.1 1 0 0 1 1 1 0 CRT10 HlyD_2 PF12700.2 CDI77136.1 - 4.5 6.3 17.5 1.5 7.8 10.5 1.5 2 0 0 2 2 2 0 HlyD family secretion protein Serinc PF03348.10 CDI77136.1 - 4.7 5.8 20.5 8.8 4.9 14.2 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) eIF3_subunit PF08597.5 CDI77136.1 - 5.2 6.5 21.4 7.8 5.9 14.9 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF1510 PF07423.6 CDI77136.1 - 5.4 6.3 26.1 8 5.7 18.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Cellulose_synt PF03552.9 CDI77136.1 - 5.5 5.1 10.2 7.1 4.7 7.0 1.2 1 0 0 1 1 1 0 Cellulose synthase Paf1 PF03985.8 CDI77136.1 - 5.8 5.5 29.4 7.1 5.2 20.4 1.1 1 0 0 1 1 1 0 Paf1 DHHW PF14286.1 CDI77136.1 - 6.7 5.9 17.9 9.2 5.4 12.4 1.1 1 0 0 1 1 1 0 DHHW protein DUF853 PF05872.7 CDI77136.1 - 7 4.8 15.8 10 4.3 10.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RR_TM4-6 PF06459.7 CDI77136.1 - 8.8 6.1 22.8 12 5.6 15.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DSPn PF14671.1 CDI77137.1 - 6.3e-47 159.1 0.1 1.6e-46 157.7 0.1 1.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 CDI77137.1 - 8.2e-10 38.3 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDI77137.1 - 0.00055 19.3 0.0 0.00091 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 CDI77137.1 - 0.0066 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 CDI77137.1 - 0.057 13.6 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Methyltransf_26 PF13659.1 CDI77138.1 - 1.7e-10 40.9 1.7 4.6e-10 39.5 0.2 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltrans_SAM PF10672.4 CDI77138.1 - 8.6e-09 34.6 0.0 2.3e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 S-adenosylmethionine-dependent methyltransferase Methyltransf_18 PF12847.2 CDI77138.1 - 5.4e-08 33.4 0.0 1.7e-07 31.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDI77138.1 - 6.1e-08 32.2 0.1 0.0013 18.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_31 PF13847.1 CDI77138.1 - 0.00014 21.4 0.0 0.34 10.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Cons_hypoth95 PF03602.10 CDI77138.1 - 0.0024 17.3 0.3 0.71 9.2 0.4 2.3 2 0 0 2 2 2 2 Conserved hypothetical protein 95 PrmA PF06325.8 CDI77138.1 - 0.011 14.8 0.1 0.02 14.0 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 CDI77138.1 - 0.036 14.4 0.0 0.13 12.6 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 CDI77138.1 - 0.076 12.1 0.0 8.4 5.4 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 CDI77138.1 - 0.076 13.5 0.0 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.20 CDI77139.1 - 2.2e-36 125.3 0.0 3.1e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77139.1 - 1.3e-24 86.6 0.0 2e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI77139.1 - 0.00066 19.4 0.1 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Exo_endo_phos PF03372.18 CDI77140.1 - 1.6e-06 28.2 0.0 1.3e-05 25.2 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pol_alpha_B_N PF08418.5 CDI77142.1 - 0.02 14.4 4.8 0.015 14.8 2.5 1.4 1 1 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal HrcA PF01628.16 CDI77142.1 - 0.072 12.6 0.2 0.1 12.1 0.2 1.3 1 0 0 1 1 1 0 HrcA protein C terminal domain Use1 PF09753.4 CDI77142.1 - 0.24 10.7 2.5 0.35 10.2 1.7 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 PAT1 PF09770.4 CDI77142.1 - 0.46 8.6 11.8 0.56 8.3 8.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2695 PF10905.3 CDI77142.1 - 0.52 10.0 1.7 8.2 6.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2695) IMPDH PF00478.20 CDI77143.1 - 1.5e-129 431.9 0.0 2.4e-129 431.2 0.0 1.3 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 CDI77143.1 - 3.9e-14 52.1 0.1 1.5e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 CDI77143.1 - 5.6e-12 45.4 7.5 2.6e-07 30.1 4.0 2.8 2 1 0 3 3 3 2 Nitronate monooxygenase FMN_dh PF01070.13 CDI77143.1 - 4.9e-09 35.4 3.2 5.7e-09 35.2 0.9 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 CDI77143.1 - 2.1e-05 23.9 2.4 0.00013 21.2 1.6 2.2 1 1 0 1 1 1 1 Histidine biosynthesis protein NanE PF04131.9 CDI77143.1 - 0.0014 17.5 1.7 0.19 10.6 1.2 2.8 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.9 CDI77143.1 - 0.0037 16.3 2.0 0.0075 15.3 1.3 1.5 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.12 CDI77143.1 - 0.0038 16.3 1.1 0.023 13.8 0.6 2.2 2 0 0 2 2 2 1 Thiamine monophosphate synthase/TENI DUF561 PF04481.7 CDI77143.1 - 0.027 13.4 0.8 0.29 10.0 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF561) PcrB PF01884.12 CDI77143.1 - 0.027 13.7 3.6 3.5 6.8 0.1 3.5 2 1 1 3 3 3 0 PcrB family DHO_dh PF01180.16 CDI77143.1 - 0.044 12.7 1.3 0.067 12.1 0.2 1.7 1 1 0 2 2 2 0 Dihydroorotate dehydrogenase CTP_transf_2 PF01467.21 CDI77147.1 - 0.027 14.5 0.0 0.093 12.7 0.0 1.9 1 0 0 1 1 1 0 Cytidylyltransferase FAD_syn PF06574.7 CDI77147.1 - 0.071 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 FAD synthetase NTP_transf_3 PF12804.2 CDI77148.1 - 8.7e-13 48.6 0.0 1.9e-12 47.5 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 CDI77148.1 - 8.4e-12 44.9 0.0 1.4e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 CDI77148.1 - 0.0056 16.1 0.0 7.1 6.3 0.0 2.9 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) CTP_transf_3 PF02348.14 CDI77148.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase TPR_14 PF13428.1 CDI77149.1 - 0.0045 17.5 1.7 0.0045 17.5 1.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI77149.1 - 0.0093 15.8 0.3 0.035 14.0 0.2 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat GMC_oxred_N PF00732.14 CDI77149.1 - 0.19 10.8 3.9 0.31 10.1 2.7 1.2 1 0 0 1 1 1 0 GMC oxidoreductase LRR_4 PF12799.2 CDI77151.1 - 9.1e-22 76.2 14.6 7.1e-09 35.0 0.6 5.3 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI77151.1 - 1.4e-13 50.3 8.5 6.2e-07 29.0 2.0 3.9 2 2 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.1 CDI77151.1 - 1.4e-06 27.7 6.8 1.6 9.0 0.0 7.4 8 0 0 8 8 8 1 Leucine Rich repeat LRR_1 PF00560.28 CDI77151.1 - 2e-06 27.0 17.3 0.081 13.0 0.1 7.5 7 1 1 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.1 CDI77151.1 - 3.2e-05 23.5 0.8 0.002 17.6 0.1 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 CDI77151.1 - 0.00032 20.4 14.8 14 6.3 0.0 7.9 8 1 1 9 9 9 1 Leucine rich repeat LRV PF01816.12 CDI77151.1 - 0.12 12.6 1.2 0.69 10.2 0.8 2.5 1 0 0 1 1 1 0 Leucine rich repeat variant MSC PF09402.5 CDI77152.1 - 2.4e-13 49.5 0.8 3.3e-13 49.0 0.6 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain Guanylate_cyc PF00211.15 CDI77153.1 - 2.5e-18 66.1 0.9 4.4e-18 65.3 0.1 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.26 CDI77153.1 - 6.4e-08 32.0 3.8 6.4e-08 32.0 2.6 1.9 2 0 0 2 2 2 1 Ion transport protein DUF1635 PF07795.6 CDI77155.1 - 0.0041 16.5 0.4 0.0041 16.5 0.3 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1635) DUF581 PF04570.9 CDI77155.1 - 0.057 12.7 0.2 10 5.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF581) zinc_ribbon_2 PF13240.1 CDI77157.1 - 2.7 7.5 4.7 3.6 7.1 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Neisseria_TspB PF05616.8 CDI77157.1 - 5.9 5.1 6.3 0.48 8.7 0.4 1.8 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein PK_C PF02887.11 CDI77158.1 - 0.035 13.6 0.1 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain Ank PF00023.25 CDI77159.1 - 4.8e-11 41.8 0.3 0.0002 20.9 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CDI77159.1 - 1.6e-10 40.8 0.0 1.6e-06 28.1 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDI77159.1 - 2.9e-10 40.3 0.1 1.2e-07 32.0 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI77159.1 - 4.6e-10 39.6 0.0 8.9e-10 38.7 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CDI77159.1 - 6.8e-06 25.8 0.0 0.06 13.6 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Med15 PF09606.5 CDI77160.1 - 8.1 4.5 8.6 9 4.3 5.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SAE2 PF08573.5 CDI77161.1 - 1.6e-05 25.4 11.5 1.6e-05 25.4 8.0 5.9 7 1 0 7 7 7 1 DNA repair protein endonuclease SAE2/CtIP C-terminus SPX PF03105.14 CDI77161.1 - 0.39 10.4 0.0 0.39 10.4 0.0 5.9 2 1 2 5 5 5 0 SPX domain AP2 PF00847.15 CDI77162.1 - 8.3e-07 29.0 0.3 8.3e-07 29.0 0.2 4.9 7 0 0 7 7 7 1 AP2 domain MtN3_slv PF03083.11 CDI77163.1 - 6.4e-34 115.6 7.3 7e-19 67.4 0.5 2.4 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange Phostensin_N PF13916.1 CDI77163.1 - 0.013 15.4 3.8 0.036 14.0 2.6 1.7 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Peptidase_S64 PF08192.6 CDI77163.1 - 8.1 4.6 5.8 11 4.1 4.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 zf-HC5HC2H_2 PF13832.1 CDI77165.1 - 8.4e-08 32.1 20.9 9.1e-07 28.8 12.9 6.4 6 1 0 6 6 6 2 PHD-zinc-finger like domain PHD_2 PF13831.1 CDI77165.1 - 1.3e-07 30.8 17.3 1.3e-05 24.3 0.9 4.0 4 0 0 4 4 4 2 PHD-finger PHD PF00628.24 CDI77165.1 - 0.00016 21.3 9.8 0.00016 21.3 6.8 4.8 4 0 0 4 4 4 2 PHD-finger zf-HC5HC2H PF13771.1 CDI77165.1 - 1.6 8.9 46.0 0.029 14.5 11.8 6.3 5 1 1 6 6 6 0 PHD-like zinc-binding domain Plasmodium_Vir PF05795.6 CDI77166.1 - 0.11 11.6 0.9 0.11 11.6 0.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PAT1 PF09770.4 CDI77166.1 - 0.11 10.6 23.1 0.12 10.5 16.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI77166.1 - 0.12 12.2 14.0 0.14 12.0 9.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Serinc PF03348.10 CDI77166.1 - 0.14 10.8 0.3 0.21 10.2 0.2 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.1 CDI77166.1 - 0.15 10.1 0.6 0.22 9.6 0.2 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 CDK2AP PF09806.4 CDI77166.1 - 0.16 12.1 10.3 0.25 11.5 7.1 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Folate_carrier PF01770.13 CDI77166.1 - 0.21 10.0 0.8 0.24 9.8 0.6 1.2 1 0 0 1 1 1 0 Reduced folate carrier Neur_chan_memb PF02932.11 CDI77166.1 - 0.4 10.5 3.5 0.5 10.2 2.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BBS2_C PF14782.1 CDI77166.1 - 0.59 8.6 7.3 0.7 8.3 5.0 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal OmpH PF03938.9 CDI77166.1 - 3 7.7 23.1 4.6 7.1 16.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2946 PF11162.3 CDI77166.1 - 4.6 7.4 6.7 0.67 10.1 0.6 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) DUF4175 PF13779.1 CDI77166.1 - 5 4.7 23.9 6.8 4.2 16.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TSA PF03249.8 CDI77166.1 - 7.3 5.0 12.4 9.2 4.6 8.6 1.1 1 0 0 1 1 1 0 Type specific antigen Myosin_head PF00063.16 CDI77167.1 - 8.5e-166 552.9 0.0 1.6e-165 552.0 0.0 1.4 1 1 0 1 1 1 1 Myosin head (motor domain) DEAD PF00270.24 CDI77167.1 - 0.011 15.1 0.0 2.8 7.4 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase Dynein_light PF01221.13 CDI77167.1 - 0.015 15.2 0.0 0.015 15.2 0.0 2.1 2 0 0 2 2 2 0 Dynein light chain type 1 AAA_22 PF13401.1 CDI77167.1 - 0.019 15.1 0.3 0.14 12.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 CDI77168.1 - 1.1 9.6 3.7 2 8.6 0.3 2.0 2 0 0 2 2 2 0 AAA domain TMEM51 PF15345.1 CDI77169.1 - 0.5 10.0 1.8 0.44 10.1 0.1 1.7 2 1 1 3 3 3 0 Transmembrane protein 51 GshA PF08886.6 CDI77170.1 - 0.15 10.3 0.0 0.2 9.9 0.0 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase Mnd1 PF03962.10 CDI77174.1 - 0.17 11.5 0.1 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 Mnd1 family SNAP PF14938.1 CDI77175.1 - 0.52 9.3 11.3 0.17 11.0 2.3 2.1 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP SR-25 PF10500.4 CDI77177.1 - 0.73 9.2 20.2 0.041 13.3 6.3 2.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PCI PF01399.22 CDI77178.1 - 3.1e-09 37.0 0.0 8.2e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 CDI77178.1 - 0.00031 20.5 0.0 0.00085 19.1 0.0 1.7 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 TPR_7 PF13176.1 CDI77178.1 - 0.11 12.3 5.5 23 5.0 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDI77178.1 - 0.12 12.3 3.9 1.2 9.2 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Asp_protease_2 PF13650.1 CDI77180.1 - 5.2e-06 26.8 0.0 2e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 CDI77180.1 - 0.00018 21.2 0.4 0.00039 20.1 0.1 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 CDI77180.1 - 0.0008 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 CDI77180.1 - 0.0024 17.7 0.0 0.0053 16.6 0.0 1.6 1 1 0 1 1 1 1 Retroviral aspartyl protease Pam16 PF03656.8 CDI77180.1 - 0.1 12.4 0.0 0.78 9.5 0.0 2.0 2 0 0 2 2 2 0 Pam16 DUF605 PF04652.11 CDI77181.1 - 0.00088 18.7 30.8 0.00088 18.7 21.4 2.3 2 0 0 2 2 2 2 Vta1 like CAF-1_p150 PF11600.3 CDI77181.1 - 0.0028 17.0 19.4 0.0028 17.0 13.5 3.8 3 1 1 4 4 4 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal SOBP PF15279.1 CDI77181.1 - 0.0071 16.7 40.4 0.23 11.8 5.2 2.6 2 0 0 2 2 2 2 Sine oculis-binding protein FimP PF09766.4 CDI77181.1 - 0.0076 15.3 9.5 0.0076 15.3 6.6 3.4 2 1 2 4 4 4 1 Fms-interacting protein DUF4337 PF14235.1 CDI77181.1 - 0.0086 15.9 6.6 0.0086 15.9 4.6 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4337) SprA-related PF12118.3 CDI77181.1 - 0.024 13.9 77.9 0.014 14.6 15.0 2.9 3 0 0 3 3 3 0 SprA-related family PAT1 PF09770.4 CDI77181.1 - 0.076 11.2 53.4 0.14 10.3 8.4 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI77181.1 - 0.088 10.9 62.2 0.027 12.6 11.9 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_23 PF13476.1 CDI77181.1 - 0.49 10.7 23.7 0.12 12.7 4.6 2.3 2 0 0 2 2 2 0 AAA domain TFIIA PF03153.8 CDI77181.1 - 4.6 7.0 55.0 3.8 7.3 10.2 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit IF4E PF01652.13 CDI77182.1 - 0.0012 18.4 0.1 0.013 15.0 0.1 2.0 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E DUF155 PF02582.9 CDI77184.1 - 2.2e-09 37.4 0.0 3.3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Gly-zipper_OmpA PF13436.1 CDI77184.1 - 0.00029 20.4 26.7 0.00061 19.4 18.5 1.5 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain DUF1777 PF08648.7 CDI77184.1 - 0.73 9.5 6.4 1.2 8.8 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) MSP1_C PF07462.6 CDI77184.1 - 7.6 4.7 10.0 11 4.2 6.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Pkinase PF00069.20 CDI77186.1 - 1.3e-29 103.1 0.0 3.5e-29 101.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77186.1 - 2.6e-11 43.0 0.0 4.6e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Hid1 PF12722.2 CDI77186.1 - 0.049 11.3 1.4 0.078 10.6 1.0 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med15 PF09606.5 CDI77186.1 - 1.3 7.0 31.1 2 6.5 21.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal IncA PF04156.9 CDI77186.1 - 2.9 7.4 14.0 4.5 6.8 0.0 2.5 2 0 0 2 2 2 0 IncA protein Pex16 PF08610.5 CDI77187.1 - 1.7 7.5 6.3 3.1 6.7 4.4 1.4 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) FimP PF09766.4 CDI77187.1 - 4.1 6.3 17.5 0.45 9.5 5.3 2.2 2 0 0 2 2 2 0 Fms-interacting protein PH_4 PF15404.1 CDI77187.1 - 5.8 6.3 10.2 35 3.8 7.1 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain Band_3_cyto PF07565.8 CDI77187.1 - 7.5 5.9 8.9 15 4.9 6.2 1.6 1 1 0 1 1 1 0 Band 3 cytoplasmic domain eIF3_subunit PF08597.5 CDI77188.1 - 0.0024 17.4 1.5 0.0024 17.4 1.1 17.7 11 4 7 18 18 18 1 Translation initiation factor eIF3 subunit Syntaxin-6_N PF09177.6 CDI77189.1 - 0.0017 18.7 3.0 0.0017 18.7 2.1 3.1 3 0 0 3 3 3 1 Syntaxin 6, N-terminal DUF3675 PF12428.3 CDI77189.1 - 0.014 15.6 0.3 0.062 13.5 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3675) Ribosomal_60s PF00428.14 CDI77189.1 - 0.031 14.6 5.3 0.031 14.6 3.7 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein CorA PF01544.13 CDI77189.1 - 0.35 9.8 11.0 0.14 11.1 4.3 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Cytochrom_B562 PF07361.6 CDI77189.1 - 0.43 11.0 10.1 2.4 8.6 0.4 3.2 3 1 0 3 3 3 0 Cytochrome b562 DUF1664 PF07889.7 CDI77189.1 - 2.7 7.7 12.8 0.2 11.4 1.8 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Pkinase PF00069.20 CDI77191.1 - 9.4e-68 228.1 0.0 1.2e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77191.1 - 5e-40 137.2 0.1 8.1e-40 136.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.27 CDI77191.1 - 7.4e-17 59.2 1.0 3.3e-06 26.0 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 CDI77191.1 - 1.4e-15 57.1 0.2 5.6e-08 32.8 0.0 3.6 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI77191.1 - 1.1e-14 52.9 1.8 5.5e-05 22.7 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 CDI77191.1 - 2e-14 52.9 2.4 4.2e-06 26.2 0.0 4.4 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 CDI77191.1 - 3e-11 42.1 3.2 2.8e-05 23.2 0.1 4.5 5 0 0 5 5 5 2 EF hand Kinase-like PF14531.1 CDI77191.1 - 5e-06 25.6 0.0 7.3e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDI77191.1 - 5.4e-06 25.6 0.0 9.4e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDI77191.1 - 0.0021 17.8 0.0 0.23 11.1 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDI77191.1 - 0.022 14.3 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.4 CDI77191.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PDH PF02153.12 CDI77191.1 - 0.028 13.3 0.0 0.045 12.6 0.0 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase DUF789 PF05623.7 CDI77192.1 - 9e-27 94.2 4.3 9e-27 94.2 3.0 7.7 7 2 0 7 7 7 1 Protein of unknown function (DUF789) Hid1 PF12722.2 CDI77193.1 - 0.001 16.8 1.9 0.0011 16.7 1.3 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Plasmodium_Vir PF05795.6 CDI77193.1 - 0.0012 18.1 0.1 0.0016 17.7 0.1 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Pex14_N PF04695.8 CDI77193.1 - 0.0012 18.8 5.7 0.0022 18.0 3.9 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CDC45 PF02724.9 CDI77193.1 - 0.0083 14.2 8.1 0.01 13.9 5.6 1.1 1 0 0 1 1 1 1 CDC45-like protein Ycf1 PF05758.7 CDI77193.1 - 0.016 12.9 4.7 0.018 12.7 3.3 1.0 1 0 0 1 1 1 0 Ycf1 Sec62 PF03839.11 CDI77193.1 - 0.03 13.7 1.6 0.045 13.1 1.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 FAM60A PF15396.1 CDI77193.1 - 0.073 12.8 1.9 0.099 12.3 1.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF4407 PF14362.1 CDI77193.1 - 0.24 10.3 5.9 0.33 9.8 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.7 CDI77193.1 - 0.64 9.8 13.3 0.98 9.2 9.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.9 CDI77193.1 - 1.1 8.9 10.4 1.5 8.5 7.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Daxx PF03344.10 CDI77193.1 - 1.1 7.6 22.2 1.5 7.2 15.4 1.1 1 0 0 1 1 1 0 Daxx Family Presenilin PF01080.12 CDI77193.1 - 1.1 7.9 6.0 1.5 7.5 4.1 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.7 CDI77193.1 - 1.1 7.0 17.6 1.5 6.6 12.2 1.1 1 0 0 1 1 1 0 Nop14-like family SID-1_RNA_chan PF13965.1 CDI77193.1 - 2 6.4 3.1 2.6 6.1 2.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2201_N PF13203.1 CDI77193.1 - 2.9 7.0 17.1 4.5 6.3 11.8 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain Band_3_cyto PF07565.8 CDI77193.1 - 3.3 7.1 8.4 4.9 6.5 5.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain BAF1_ABF1 PF04684.8 CDI77193.1 - 7.6 5.2 15.4 11 4.6 10.7 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TP53IP5 PF15331.1 CDI77193.1 - 8 6.3 9.3 15 5.4 6.4 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF913 PF06025.7 CDI77193.1 - 8.1 5.0 6.6 12 4.5 4.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ndc1_Nup PF09531.5 CDI77193.1 - 8.2 4.7 5.6 11 4.3 3.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SR-25 PF10500.4 CDI77194.1 - 2.1e-05 24.1 5.0 2.1e-05 24.1 3.5 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.14 CDI77194.1 - 0.023 15.0 9.4 0.031 14.6 5.6 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3628 PF12300.3 CDI77194.1 - 0.47 10.4 7.6 0.56 10.2 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3628) DUF3446 PF11928.3 CDI77194.1 - 0.51 10.5 9.7 0.23 11.6 2.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) Suf PF05843.9 CDI77195.1 - 0.0037 17.0 13.7 0.049 13.3 4.5 2.3 2 0 0 2 2 2 2 Suppressor of forked protein (Suf) WD40 PF00400.27 CDI77195.1 - 0.0045 16.8 12.6 0.077 12.9 3.9 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Corona_nucleoca PF00937.13 CDI77195.1 - 0.013 14.5 26.0 0.033 13.1 7.7 2.2 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein Activator_LAG-3 PF11498.3 CDI77195.1 - 0.014 14.1 33.0 0.011 14.4 9.1 2.5 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Ribosomal_60s PF00428.14 CDI77195.1 - 0.02 15.2 3.6 0.02 15.2 2.5 4.6 3 1 1 4 4 4 0 60s Acidic ribosomal protein EphA2_TM PF14575.1 CDI77195.1 - 0.63 10.4 3.4 5.2 7.5 1.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SGT1 PF07093.6 CDI77195.1 - 8.7 4.5 16.0 17 3.5 11.1 1.4 1 0 0 1 1 1 0 SGT1 protein EF-hand_6 PF13405.1 CDI77199.1 - 0.00025 20.6 0.2 0.15 12.0 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 CDI77199.1 - 0.00034 20.6 1.1 0.036 14.1 0.0 3.6 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI77199.1 - 0.018 14.2 0.1 0.23 10.8 0.0 2.6 3 0 0 3 3 3 0 EF hand Hydrolase_3 PF08282.7 CDI77200.1 - 3.8e-30 105.3 0.0 6.7e-19 68.4 0.0 2.0 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDI77200.1 - 0.00039 20.8 0.1 0.44 10.9 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.8 CDI77200.1 - 0.0046 16.2 0.0 0.56 9.4 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.2 CDI77200.1 - 0.021 14.9 1.3 4.5 7.3 0.1 2.5 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Rsa3 PF14615.1 CDI77201.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Ribosome-assembly protein 3 HR1 PF02185.11 CDI77202.1 - 0.033 13.9 0.9 0.033 13.9 0.6 3.0 3 0 0 3 3 3 0 Hr1 repeat DivIC PF04977.10 CDI77202.1 - 0.35 10.3 9.4 0.044 13.2 2.3 2.2 1 1 1 2 2 2 0 Septum formation initiator MAS20 PF02064.10 CDI77202.1 - 3.6 7.5 6.4 2.2 8.1 2.3 2.1 2 0 0 2 2 2 0 MAS20 protein import receptor ACDC PF14733.1 CDI77207.1 - 4.7e-09 36.2 0.0 4.7e-09 36.2 0.0 1.8 2 0 0 2 2 2 1 AP2-coincident C-terminal AP2 PF00847.15 CDI77207.1 - 3.1e-07 30.4 0.2 3.1e-07 30.4 0.2 4.3 6 0 0 6 6 6 1 AP2 domain KIAA1328 PF15369.1 CDI77208.1 - 0.26 11.0 4.1 0.5 10.1 2.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Vps16_C PF04840.7 CDI77212.1 - 5.6e-32 110.9 3.2 2.9e-31 108.6 2.2 2.0 1 1 0 1 1 1 1 Vps16, C-terminal region ANTH PF07651.11 CDI77212.1 - 0.12 11.0 0.6 0.52 8.9 0.1 2.1 2 0 0 2 2 2 0 ANTH domain Lipase_3 PF01764.20 CDI77214.1 - 6.4e-10 38.7 0.1 1.3e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 CDI77214.1 - 0.0043 16.4 0.0 0.008 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Zip PF02535.17 CDI77214.1 - 0.018 14.0 1.8 0.033 13.1 1.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF676 PF05057.9 CDI77214.1 - 0.075 12.3 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Innate_immun PF12782.2 CDI77214.1 - 0.2 10.8 10.8 0.35 10.0 7.5 1.3 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Fe-S_biosyn PF01521.15 CDI77215.1 - 2.2e-07 30.8 0.0 0.00018 21.4 0.0 2.6 2 1 0 2 2 2 2 Iron-sulphur cluster biosynthesis DUF4603 PF15376.1 CDI77215.1 - 0.09 9.9 1.2 0.12 9.5 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) SR-25 PF10500.4 CDI77215.1 - 0.42 10.0 3.9 0.82 9.1 2.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NDK PF00334.14 CDI77216.1 - 2e-28 98.8 0.0 2.8e-25 88.6 0.0 2.2 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF4147 PF13660.1 CDI77216.1 - 0.018 14.1 1.4 0.029 13.4 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) Med3 PF11593.3 CDI77216.1 - 0.59 9.3 8.7 0.82 8.8 6.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal AAA_5 PF07728.9 CDI77217.1 - 1.8e-95 316.1 0.0 5.5e-13 48.8 0.0 11.9 11 0 0 11 11 11 9 AAA domain (dynein-related subfamily) AAA PF00004.24 CDI77217.1 - 3.9e-18 65.9 0.0 0.0081 16.3 0.0 6.5 5 0 0 5 5 5 5 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.6 CDI77217.1 - 3e-13 49.5 0.0 0.0039 16.7 0.0 7.2 8 0 0 8 8 8 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI77217.1 - 4.8e-13 49.3 0.5 0.13 12.3 0.0 8.0 7 0 0 7 7 6 3 AAA domain AAA_17 PF13207.1 CDI77217.1 - 1.8e-11 44.8 0.0 0.43 11.4 0.0 5.6 5 0 0 5 5 5 3 AAA domain UPF0079 PF02367.12 CDI77217.1 - 1.4e-07 31.1 0.8 1.5 8.4 0.0 5.5 5 0 0 5 5 5 2 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 CDI77217.1 - 5.5e-07 29.5 41.0 0.00056 19.8 0.0 9.2 8 1 0 8 8 5 4 AAA domain RNA_helicase PF00910.17 CDI77217.1 - 1.9e-05 24.8 0.0 16 5.6 0.0 5.4 5 0 0 5 5 5 0 RNA helicase AAA_18 PF13238.1 CDI77217.1 - 1.9e-05 24.9 0.0 8.2 6.7 0.0 5.7 5 0 0 5 5 5 1 AAA domain AAA_14 PF13173.1 CDI77217.1 - 0.00014 21.7 0.0 1.1 9.1 0.0 4.8 5 0 0 5 5 4 1 AAA domain Miro PF08477.8 CDI77217.1 - 0.0058 17.1 0.0 2e+02 2.4 0.0 5.3 4 0 0 4 4 4 0 Miro-like protein Rad17 PF03215.10 CDI77217.1 - 0.26 9.9 0.3 8.7 4.8 0.0 2.7 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein MobB PF03205.9 CDI77217.1 - 0.43 10.2 0.0 58 3.3 0.0 3.5 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B Rhabdo_glycop PF00974.13 CDI77217.1 - 3.6 5.7 0.1 5.9 5.0 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein zf-RING_2 PF13639.1 CDI77218.1 - 2.2e-09 36.9 12.8 2.2e-09 36.9 8.9 2.5 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CDI77218.1 - 0.00016 21.6 6.0 0.00016 21.6 4.1 2.7 3 0 0 3 3 3 1 RING-H2 zinc finger Eapp_C PF10238.4 CDI77218.1 - 0.0077 16.1 2.3 0.0077 16.1 1.6 4.3 5 0 0 5 5 5 1 E2F-associated phosphoprotein zf-C3HC4 PF00097.20 CDI77218.1 - 0.01 15.5 12.9 0.01 15.5 8.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI77218.1 - 0.44 10.6 20.2 0.017 15.1 9.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI77218.1 - 4.1 7.2 20.8 0.29 10.8 7.9 2.6 2 0 0 2 2 2 0 zinc-RING finger domain RCC1 PF00415.13 CDI77219.1 - 0.00087 19.4 0.0 0.0022 18.1 0.0 1.7 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat DUF1183 PF06682.7 CDI77219.1 - 0.0084 15.7 7.1 0.0084 15.7 4.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1183) FAM163 PF15069.1 CDI77219.1 - 0.059 13.9 0.1 0.16 12.5 0.1 1.7 1 0 0 1 1 1 0 FAM163 family FHIPEP PF00771.15 CDI77219.1 - 0.094 11.0 1.3 0.15 10.3 0.9 1.3 1 0 0 1 1 1 0 FHIPEP family Neur_chan_memb PF02932.11 CDI77219.1 - 0.15 11.8 2.4 0.27 11.0 1.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.2 CDI77219.1 - 0.28 8.8 4.1 0.39 8.3 2.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.4 CDI77219.1 - 0.45 8.6 31.9 0.085 11.0 16.9 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 XAP5 PF04921.9 CDI77219.1 - 1.4 8.4 4.7 2.3 7.7 3.3 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator SpoIIIAH PF12685.2 CDI77219.1 - 1.8 7.9 10.4 0.24 10.8 3.7 1.9 2 0 0 2 2 2 0 SpoIIIAH-like protein Ribosomal_60s PF00428.14 CDI77219.1 - 2.3 8.7 53.4 1 9.8 4.2 4.3 4 0 0 4 4 4 0 60s Acidic ribosomal protein TORC_N PF12884.2 CDI77226.1 - 0.012 16.1 7.0 0.018 15.5 3.7 2.1 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus JAB PF01398.16 CDI77226.1 - 0.021 14.5 0.1 0.056 13.1 0.1 1.7 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF244 PF03112.9 CDI77226.1 - 0.032 13.7 0.3 0.056 12.9 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF CBP4 PF07960.6 CDI77226.1 - 0.034 13.7 7.4 0.091 12.3 5.1 1.7 1 0 0 1 1 1 0 CBP4 Spt20 PF12090.3 CDI77226.1 - 0.041 13.2 3.4 0.02 14.2 0.9 1.6 2 0 0 2 2 2 0 Spt20 family BaffR-Tall_bind PF09256.5 CDI77226.1 - 0.043 13.4 3.0 0.81 9.3 0.1 2.5 2 0 0 2 2 2 0 BAFF-R, TALL-1 binding FliD_N PF02465.13 CDI77226.1 - 0.062 13.6 4.0 0.12 12.8 2.8 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus TcdA_TcdB PF12919.2 CDI77226.1 - 0.083 11.3 5.7 0.12 10.8 4.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain SPT16 PF08644.6 CDI77226.1 - 0.15 11.8 5.6 0.43 10.4 3.9 1.7 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) R3H-assoc PF13902.1 CDI77226.1 - 0.39 10.6 0.1 0.39 10.6 0.0 2.7 2 1 1 3 3 2 0 R3H-associated N-terminal domain RasGAP_C PF03836.10 CDI77226.1 - 0.41 10.3 14.1 1.5 8.4 7.7 2.2 1 1 1 2 2 2 0 RasGAP C-terminus GvpL_GvpF PF06386.6 CDI77226.1 - 0.62 9.6 8.5 1.4 8.4 5.9 1.6 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Tox-ODYAM1 PF15642.1 CDI77226.1 - 0.74 8.4 7.8 0.68 8.5 4.8 1.4 1 1 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Glyco_transf_8 PF01501.15 CDI77226.1 - 1.1 8.5 5.2 0.68 9.2 2.1 1.7 2 0 0 2 2 2 0 Glycosyl transferase family 8 GN3L_Grn1 PF08701.6 CDI77226.1 - 1.5 8.7 12.3 4.8 7.1 8.5 1.8 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase DUF4557 PF15101.1 CDI77226.1 - 1.5 8.6 8.9 2.4 7.9 5.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4557) Allexi_40kDa PF05549.6 CDI77226.1 - 2.5 7.3 6.2 2.8 7.1 3.4 1.7 1 1 0 1 1 1 0 Allexivirus 40kDa protein BAF1_ABF1 PF04684.8 CDI77226.1 - 3.3 6.4 10.3 4.2 6.1 7.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor 60KD_IMP PF02096.15 CDI77226.1 - 3.4 7.2 9.1 4.1 6.9 5.4 1.7 2 0 0 2 2 2 0 60Kd inner membrane protein DUF4446 PF14584.1 CDI77226.1 - 5.5 6.8 8.5 1.6 8.5 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) OmpH PF03938.9 CDI77226.1 - 6.7 6.6 23.3 18 5.2 16.1 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4570 PF15134.1 CDI77226.1 - 7.1 6.5 15.5 14 5.5 10.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4570) DUF342 PF03961.8 CDI77226.1 - 7.4 4.8 9.4 8.5 4.6 6.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Phage_Mu_Gam PF07352.7 CDI77226.1 - 8.9 5.8 13.7 0.82 9.1 4.7 2.2 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein ABC_tran PF00005.22 CDI77227.1 - 2e-25 89.6 0.0 8e-24 84.4 0.0 2.6 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 CDI77227.1 - 1.3e-05 25.3 0.0 0.12 12.3 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CDI77227.1 - 0.00031 20.1 0.0 0.00062 19.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 CDI77227.1 - 0.0045 16.2 0.0 0.19 10.9 0.0 2.4 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDI77227.1 - 0.0054 16.2 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.7 CDI77227.1 - 0.012 14.7 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.1 CDI77227.1 - 0.042 14.1 1.4 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 CDI77227.1 - 0.047 13.6 0.1 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 CDI77228.1 - 2.1e-15 57.1 0.0 1.5e-13 51.2 0.0 3.4 2 1 0 2 2 2 1 ABC transporter FHIPEP PF00771.15 CDI77228.1 - 0.0003 19.2 2.6 0.00055 18.4 1.8 1.3 1 0 0 1 1 1 1 FHIPEP family AAA_29 PF13555.1 CDI77228.1 - 0.0031 17.0 1.9 0.0065 15.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dynamin_N PF00350.18 CDI77228.1 - 0.023 14.5 7.0 0.38 10.5 0.2 2.6 2 0 0 2 2 2 0 Dynamin family Arch_ATPase PF01637.13 CDI77228.1 - 0.34 10.5 0.0 0.59 9.7 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Miro PF08477.8 CDI77228.1 - 0.39 11.2 0.0 0.39 11.2 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein AAA_23 PF13476.1 CDI77228.1 - 1.5 9.1 0.0 1.5 9.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain Aldo_ket_red PF00248.16 CDI77229.1 - 7.6e-10 38.0 0.0 1.9e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Aldo/keto reductase family LMBR1 PF04791.11 CDI77229.1 - 0.24 9.9 0.1 0.43 9.1 0.1 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2347 PF09804.4 CDI77229.1 - 0.96 8.6 7.7 1.7 7.8 5.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Cellulose_synt PF03552.9 CDI77229.1 - 2 6.6 2.6 2.9 6.0 1.8 1.1 1 0 0 1 1 1 0 Cellulose synthase Ycf1 PF05758.7 CDI77229.1 - 3.5 5.2 14.9 6 4.4 10.4 1.3 1 0 0 1 1 1 0 Ycf1 AAA_23 PF13476.1 CDI77229.1 - 3.8 7.7 22.4 0.53 10.5 10.5 2.2 2 0 0 2 2 2 0 AAA domain Zip PF02535.17 CDI77229.1 - 9.3 5.1 6.0 18 4.2 4.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.3 CDI77230.1 - 1.3 8.6 5.3 1.4 8.5 3.7 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Herpes_UL87 PF03043.9 CDI77232.1 - 0.061 11.7 1.6 3.6 5.8 0.0 2.7 2 1 1 3 3 3 0 Herpesvirus UL87 family Raftlin PF15250.1 CDI77232.1 - 2.3 6.6 14.2 0.59 8.5 5.0 2.2 2 0 0 2 2 2 0 Raftlin AUX_IAA PF02309.11 CDI77232.1 - 6.7 6.3 14.5 0.4 10.3 3.8 2.6 2 0 0 2 2 2 0 AUX/IAA family DUF1180 PF06679.7 CDI77233.1 - 0.25 11.2 2.7 0.48 10.2 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DDE_Tnp_ISL3 PF01610.12 CDI77233.1 - 3.9 6.9 5.6 0.5 9.9 0.3 1.8 2 0 0 2 2 2 0 Transposase DUF1253 PF06862.7 CDI77235.1 - 2.1e-35 122.0 3.4 2.1e-35 122.0 2.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) Activator_LAG-3 PF11498.3 CDI77237.1 - 1.1e-05 24.3 2.6 1.1e-05 24.3 1.8 4.0 4 0 0 4 4 4 2 Transcriptional activator LAG-3 Cwf_Cwc_15 PF04889.7 CDI77237.1 - 0.0089 15.7 6.8 0.0089 15.7 4.7 3.4 3 0 0 3 3 3 2 Cwf15/Cwc15 cell cycle control protein FXR1P_C PF12235.3 CDI77239.1 - 0.24 11.5 4.7 0.98 9.5 0.6 2.3 2 0 0 2 2 2 0 Fragile X-related 1 protein C terminal Dynein_light PF01221.13 CDI77240.1 - 1.5e-41 140.2 0.4 1.5e-41 140.2 0.3 1.8 2 0 0 2 2 2 1 Dynein light chain type 1 MBF1 PF08523.5 CDI77241.1 - 1.2e-17 63.6 1.6 1.2e-17 63.6 1.1 1.7 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 CDI77241.1 - 7.2e-15 54.5 0.2 1.2e-14 53.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 CDI77241.1 - 3.4e-10 39.8 0.0 6.1e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 CDI77241.1 - 1.3e-08 34.8 0.0 2.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.1 CDI77241.1 - 0.0091 15.7 0.1 0.02 14.6 0.1 1.6 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.1 CDI77241.1 - 0.047 13.2 0.0 0.09 12.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.1 CDI77241.1 - 0.048 13.2 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0203 PF05254.7 CDI77242.1 - 0.0033 17.2 1.6 0.0054 16.5 1.1 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX6B PF02297.12 CDI77242.1 - 0.0064 16.4 2.3 0.0081 16.1 1.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Vanabin-2 PF11437.3 CDI77242.1 - 0.25 11.3 4.6 0.31 11.0 3.2 1.1 1 0 0 1 1 1 0 Vanadium-binding protein 2 Pet191_N PF10203.4 CDI77242.1 - 0.69 9.9 5.9 4.5 7.3 4.1 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 UCR_hinge PF02320.11 CDI77242.1 - 0.87 9.5 7.3 0.96 9.4 0.8 2.1 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.8 CDI77242.1 - 2.1 8.3 6.2 9.6 6.2 4.3 1.9 1 1 0 1 1 1 0 CHCH domain DUF326 PF03860.11 CDI77242.1 - 2.5 8.0 6.7 0.87 9.5 0.3 2.4 2 1 0 2 2 2 0 Domain of Unknown Function (DUF326) Transketolase_N PF00456.16 CDI77243.1 - 1.3e-121 405.4 0.3 1.1e-89 300.6 0.0 2.9 3 0 0 3 3 3 2 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 CDI77243.1 - 9.3e-38 129.4 0.0 1.5e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CDI77243.1 - 0.00022 21.1 0.0 0.00049 20.0 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 CDI77243.1 - 0.0028 16.6 0.0 0.0051 15.7 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase ACDC PF14733.1 CDI77244.1 - 4.5e-14 52.3 0.6 8.1e-14 51.5 0.4 1.4 1 0 0 1 1 1 1 AP2-coincident C-terminal Dicty_REP PF05086.7 CDI77244.1 - 0.088 10.5 0.0 0.12 10.1 0.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ribosomal_S17 PF00366.15 CDI77245.1 - 8.4e-11 41.7 0.2 1.3e-10 41.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 His_Phos_1 PF00300.17 CDI77246.1 - 1.2e-38 132.6 0.1 9.1e-26 90.8 0.0 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) CDK2AP PF09806.4 CDI77246.1 - 1.7 8.8 7.0 0.4 10.8 2.6 1.5 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Ribosomal_S17e PF00833.13 CDI77247.1 - 9.1e-60 199.7 2.1 1e-59 199.6 1.5 1.0 1 0 0 1 1 1 1 Ribosomal S17 SpoIIE PF07228.7 CDI77248.1 - 3e-12 46.6 3.8 0.0069 16.1 0.0 4.2 4 0 0 4 4 4 3 Stage II sporulation protein E (SpoIIE) OmpH PF03938.9 CDI77248.1 - 2.8e-06 27.3 21.0 2.8e-06 27.3 14.6 6.9 5 1 0 5 5 5 3 Outer membrane protein (OmpH-like) Herpes_UL87 PF03043.9 CDI77248.1 - 1.8 6.8 21.9 49 2.1 0.0 3.7 3 1 0 3 3 3 0 Herpesvirus UL87 family CDC45 PF02724.9 CDI77248.1 - 7.3 4.4 47.9 0.0075 14.3 3.4 4.3 4 0 0 4 4 4 0 CDC45-like protein MENTAL PF10457.4 CDI77248.1 - 8.8 5.9 5.6 47 3.5 0.4 2.9 2 0 0 2 2 2 0 Cholesterol-capturing domain Rad60-SLD PF11976.3 CDI77249.1 - 4.5e-24 83.9 0.0 5.4e-24 83.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 CDI77249.1 - 4.2e-08 32.4 0.0 5.4e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family zf-CSL PF05207.8 CDI77250.1 - 6.4e-08 31.9 0.0 1.5e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 CSL zinc finger Peptidase_M15 PF01427.12 CDI77250.1 - 0.073 12.6 2.1 0.2 11.2 0.1 2.2 1 1 1 2 2 2 0 D-ala-D-ala dipeptidase TSA PF03249.8 CDI77250.1 - 1.6 7.1 18.6 6.7 5.1 12.9 2.1 1 1 0 1 1 1 0 Type specific antigen V-ATPase_G PF03179.10 CDI77252.1 - 8.9e-26 90.2 8.2 1e-25 90.0 5.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ADPrib_exo_Tox PF03496.9 CDI77252.1 - 0.065 12.4 0.8 0.077 12.1 0.6 1.1 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme ATP-synt_B PF00430.13 CDI77252.1 - 0.17 11.7 9.2 0.21 11.3 6.1 1.4 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) HrpE PF06188.7 CDI77252.1 - 1 9.1 5.5 1.5 8.5 3.8 1.5 1 1 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E WD40 PF00400.27 CDI77254.1 - 3e-17 61.7 6.3 5.9e-06 25.9 0.3 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF1900 PF08954.6 CDI77256.1 - 3.8e-41 139.7 0.0 8.4e-41 138.6 0.0 1.6 2 0 0 2 2 1 1 Domain of unknown function (DUF1900) WD40 PF00400.27 CDI77256.1 - 5.9e-16 57.6 0.6 2.2e-10 40.0 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF812 PF05667.6 CDI77256.1 - 0.0017 16.9 11.3 0.0023 16.5 7.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1899 PF08953.6 CDI77256.1 - 0.0019 17.7 0.0 0.0036 16.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) Baculo_PEP_C PF04513.7 CDI77256.1 - 0.014 15.2 5.6 0.031 14.1 3.2 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Leu_zip PF15294.1 CDI77256.1 - 0.027 13.5 17.3 0.046 12.8 12.0 1.3 1 0 0 1 1 1 0 Leucine zipper Pkip-1 PF06878.6 CDI77256.1 - 0.12 12.2 7.6 0.27 11.1 1.5 2.7 3 0 0 3 3 3 0 Pkip-1 protein SIN1 PF05422.7 CDI77256.1 - 0.19 10.1 7.5 0.26 9.7 5.2 1.1 1 0 0 1 1 1 0 Stress-activated map kinase interacting protein 1 (SIN1) Shugoshin_N PF07558.6 CDI77256.1 - 0.21 11.3 2.4 13 5.6 0.1 2.9 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region GAS PF13851.1 CDI77256.1 - 0.3 10.2 21.8 0.27 10.3 11.0 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-Q PF13094.1 CDI77256.1 - 0.32 10.9 23.9 1.6 8.7 16.5 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF3496 PF12001.3 CDI77256.1 - 0.33 11.2 6.0 0.73 10.1 4.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) Spc7 PF08317.6 CDI77256.1 - 0.56 8.8 15.2 0.96 8.0 10.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.4 CDI77256.1 - 0.58 10.3 15.3 3.7 7.7 2.6 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2730 PF10805.3 CDI77256.1 - 0.63 9.7 10.3 2.2 8.0 2.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) APG6 PF04111.7 CDI77256.1 - 0.71 8.8 18.1 1.1 8.2 12.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 CDI77256.1 - 0.74 7.5 9.0 1.3 6.7 6.2 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4140 PF13600.1 CDI77256.1 - 0.75 10.2 20.0 0.57 10.6 6.6 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Tropomyosin_1 PF12718.2 CDI77256.1 - 0.75 9.6 27.9 2.4 7.9 12.2 2.3 1 1 1 2 2 2 0 Tropomyosin like Phage_GP20 PF06810.6 CDI77256.1 - 0.95 8.8 20.7 4.3 6.7 2.9 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 Reo_sigmaC PF04582.7 CDI77256.1 - 1 8.4 8.2 2.6 7.1 2.7 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Striatin PF08232.7 CDI77256.1 - 1.2 9.4 19.1 2.3 8.5 6.8 2.4 1 1 1 2 2 2 0 Striatin family SecA_DEAD PF07517.9 CDI77256.1 - 1.6 7.9 5.3 2.5 7.3 3.7 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain DUF4600 PF15372.1 CDI77256.1 - 1.8 8.7 14.3 5.4 7.2 9.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) IncA PF04156.9 CDI77256.1 - 1.9 8.0 27.0 24 4.4 18.7 2.1 1 1 0 1 1 1 0 IncA protein FlaC_arch PF05377.6 CDI77256.1 - 2.3 8.2 6.2 23 4.9 0.0 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.3 CDI77256.1 - 2.4 8.0 31.2 2.7 7.8 5.0 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Med9 PF07544.8 CDI77256.1 - 2.4 7.9 20.5 0.41 10.4 0.8 4.1 1 1 3 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 ERM PF00769.14 CDI77256.1 - 4 6.9 24.8 0.95 8.9 8.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family TPR_MLP1_2 PF07926.7 CDI77256.1 - 4 7.1 25.2 3.1 7.5 11.0 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Ax_dynein_light PF10211.4 CDI77256.1 - 5.2 6.8 20.7 0.12 12.1 7.0 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain DUF4559 PF15112.1 CDI77256.1 - 6.2 5.8 12.4 1.1 8.3 6.1 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4559) ABC_tran_2 PF12848.2 CDI77256.1 - 7.8 6.4 17.5 0.7 9.7 6.2 2.4 2 0 0 2 2 2 0 ABC transporter Fib_alpha PF08702.5 CDI77256.1 - 7.9 6.5 14.5 10 6.2 5.2 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.1 CDI77256.1 - 8.8 6.2 25.4 1.8 8.5 10.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) WXG100 PF06013.7 CDI77256.1 - 9.9 6.2 12.7 4.4 7.3 4.3 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG PRP1_N PF06424.7 CDI77258.1 - 2.6e-49 166.9 2.6 6.1e-40 136.6 0.4 2.7 2 0 0 2 2 2 2 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 CDI77258.1 - 1.3e-30 103.0 27.1 0.00077 19.8 0.3 14.5 6 3 9 15 15 15 8 Tetratricopeptide repeat TPR_19 PF14559.1 CDI77258.1 - 1.7e-17 63.5 18.4 0.0061 16.8 0.0 9.4 6 2 4 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.1 CDI77258.1 - 4.8e-15 54.9 6.8 0.081 12.5 0.0 8.8 6 3 5 11 11 11 3 TPR repeat TPR_16 PF13432.1 CDI77258.1 - 2.1e-14 53.7 15.7 0.011 16.4 0.0 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.12 CDI77258.1 - 3.2e-07 29.7 11.6 4 7.6 0.0 10.0 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDI77258.1 - 1.3e-06 28.2 5.4 1.2 9.1 0.4 6.7 6 1 1 7 7 7 2 Tetratricopeptide repeat Suf PF05843.9 CDI77258.1 - 3.3e-06 27.0 0.0 1.2 8.8 0.0 5.1 2 2 1 3 3 3 1 Suppressor of forked protein (Suf) TPR_8 PF13181.1 CDI77258.1 - 0.00042 19.8 0.5 1.7 8.5 0.0 6.1 8 0 0 8 8 7 1 Tetratricopeptide repeat ChAPs PF09295.5 CDI77258.1 - 0.0012 17.7 7.4 0.04 12.6 0.0 3.9 2 1 2 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.1 CDI77258.1 - 0.0013 18.7 6.3 7.2 7.0 0.0 8.2 12 1 1 13 13 8 1 Tetratricopeptide repeat DUF3808 PF10300.4 CDI77258.1 - 0.024 13.2 3.3 0.71 8.3 0.1 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF3808) TPR_21 PF09976.4 CDI77258.1 - 0.055 13.4 15.8 0.034 14.0 2.1 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDI77258.1 - 0.18 12.3 15.3 28 5.4 0.1 7.9 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_1 PF00515.23 CDI77258.1 - 0.34 10.5 1.7 3 7.6 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat Polyoma_coat PF00718.15 CDI77259.1 - 0.04 12.8 0.0 0.041 12.7 0.0 1.0 1 0 0 1 1 1 0 Polyomavirus coat protein Sec1 PF00995.18 CDI77261.1 - 5e-52 177.2 0.0 1.3e-47 162.7 0.0 2.3 2 1 0 2 2 2 2 Sec1 family SAP PF02037.22 CDI77262.1 - 0.096 12.2 0.1 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 SAP domain GCC2_GCC3 PF07699.8 CDI77263.1 - 2.1e-25 88.0 89.2 1.6e-08 33.9 1.4 9.8 10 0 0 10 10 10 7 GCC2 and GCC3 AAA_27 PF13514.1 CDI77263.1 - 0.045 11.4 5.3 0.066 10.8 3.7 1.1 1 0 0 1 1 1 0 AAA domain Cation_efflux PF01545.16 CDI77263.1 - 0.32 10.0 1.5 0.6 9.1 1.0 1.3 1 0 0 1 1 1 0 Cation efflux family HALZ PF02183.13 CDI77263.1 - 0.35 10.6 1.3 0.71 9.6 0.9 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF3745 PF12560.3 CDI77263.1 - 0.52 10.0 0.0 1.3 8.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3745) DUF342 PF03961.8 CDI77263.1 - 1.7 6.9 0.5 2.6 6.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) AAA_13 PF13166.1 CDI77263.1 - 2 6.7 0.5 2.8 6.3 0.3 1.1 1 0 0 1 1 1 0 AAA domain DUF1640 PF07798.6 CDI77263.1 - 4.7 7.2 2.1 7.1 6.6 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) CALCOCO1 PF07888.6 CDI77263.1 - 7.2 4.7 2.4 12 3.9 1.6 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Amino_oxidase PF01593.19 CDI77264.1 - 1.2e-34 120.2 6.7 5.6e-26 91.6 0.0 3.3 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CDI77264.1 - 3.9e-12 46.0 0.3 1.3e-11 44.3 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CDI77264.1 - 1.7e-05 24.7 0.4 3.5e-05 23.7 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI77264.1 - 6.1e-05 22.2 0.3 0.00013 21.1 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 CDI77264.1 - 0.0002 21.5 0.2 0.0002 21.5 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI77264.1 - 0.00031 21.0 0.5 0.00074 19.8 0.4 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CDI77264.1 - 0.0044 15.5 0.8 0.0044 15.5 0.5 2.3 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.17 CDI77264.1 - 0.0061 15.4 2.1 0.011 14.6 1.5 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CDI77264.1 - 0.0084 15.6 1.5 0.011 15.2 0.3 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Strep_67kDa_ant PF06100.6 CDI77264.1 - 2.4 6.4 0.1 4.2 5.6 0.0 1.3 1 0 0 1 1 1 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family OTU PF02338.14 CDI77265.1 - 0.00043 20.8 4.1 0.00092 19.7 0.0 2.8 2 1 0 2 2 2 1 OTU-like cysteine protease Med15 PF09606.5 CDI77265.1 - 0.36 8.9 18.9 0.52 8.4 13.1 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 CDI77265.1 - 0.9 9.3 7.9 1.3 8.8 5.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PseudoU_synth_2 PF00849.17 CDI77266.1 - 6.9e-23 81.2 0.1 6.9e-23 81.2 0.0 3.3 3 0 0 3 3 3 1 RNA pseudouridylate synthase MATH PF00917.21 CDI77266.1 - 0.0056 16.9 0.0 0.0056 16.9 0.0 2.1 2 0 0 2 2 2 1 MATH domain Toxin_61 PF15538.1 CDI77268.1 - 0.074 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative toxin 61 TSA PF03249.8 CDI77268.1 - 0.14 10.7 4.0 0.18 10.2 2.8 1.3 1 0 0 1 1 1 0 Type specific antigen DNA_pol_viral_N PF00242.12 CDI77268.1 - 0.33 9.9 11.1 0.41 9.6 7.7 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Sporozoite_P67 PF05642.6 CDI77268.1 - 0.56 7.9 8.0 0.74 7.5 5.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Macoilin PF09726.4 CDI77268.1 - 0.67 8.1 12.9 0.97 7.6 8.9 1.2 1 0 0 1 1 1 0 Transmembrane protein Nucleo_P87 PF07267.6 CDI77268.1 - 4.1 5.9 6.3 5.4 5.5 4.3 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NST1 PF13945.1 CDI77268.1 - 9.7 6.2 18.9 17 5.4 10.8 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator HemX PF04375.9 CDI77270.1 - 0.0025 16.4 12.6 0.0025 16.4 8.8 3.5 2 1 1 3 3 3 1 HemX Metal_resist PF13801.1 CDI77270.1 - 0.0052 16.7 10.4 0.0052 16.7 7.2 6.4 4 3 2 6 6 6 1 Heavy-metal resistance Peptidase_M3_N PF08439.5 CDI77270.1 - 0.021 14.8 0.7 0.069 13.2 0.5 1.9 1 0 0 1 1 1 0 Oligopeptidase F DUF2274 PF10038.4 CDI77270.1 - 0.12 12.5 1.7 0.45 10.6 1.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) V_ATPase_I PF01496.14 CDI77270.1 - 0.69 7.6 21.1 0.78 7.5 9.0 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.1 CDI77270.1 - 2.2 6.6 27.3 0.096 11.1 8.5 2.1 2 0 0 2 2 2 0 AAA domain Bax1-I PF01027.15 CDI77271.1 - 0.0051 16.4 5.2 0.0066 16.0 3.6 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Vma12 PF11712.3 CDI77271.1 - 0.19 11.4 0.9 0.25 11.0 0.6 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Pkinase PF00069.20 CDI77273.1 - 1.2e-60 204.9 0.0 1.8e-60 204.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77273.1 - 6.9e-31 107.2 0.0 1.1e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI77273.1 - 1.3e-07 30.8 0.0 2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDI77273.1 - 0.0013 17.8 0.0 0.0021 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 CDI77273.1 - 0.0041 16.4 0.0 0.0076 15.5 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL YukC PF10140.4 CDI77273.1 - 0.018 13.6 0.0 0.028 12.9 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC APH PF01636.18 CDI77273.1 - 0.033 13.9 0.4 0.033 13.9 0.3 2.6 3 1 0 3 3 3 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDI77273.1 - 0.068 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_60s PF00428.14 CDI77273.1 - 0.12 12.7 6.2 0.32 11.4 4.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Porphobil_deam PF01379.15 CDI77274.1 - 1.3e-40 138.5 10.2 3.8e-21 74.9 0.0 5.2 1 1 2 4 4 4 4 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 CDI77274.1 - 2.7e-13 49.7 0.4 1.1e-12 47.8 0.3 2.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Ribosomal_60s PF00428.14 CDI77274.1 - 0.013 15.9 3.2 0.013 15.9 2.2 8.0 7 1 1 8 8 8 0 60s Acidic ribosomal protein Thioredoxin_7 PF13899.1 CDI77274.1 - 0.32 11.0 4.0 0.66 10.0 0.7 3.1 3 0 0 3 3 3 0 Thioredoxin-like Glyco_transf_5 PF08323.6 CDI77275.1 - 1.6e-30 106.4 0.0 4.8e-30 104.8 0.0 1.9 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 CDI77275.1 - 2e-08 33.8 0.0 8e-08 31.8 0.0 2.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Med3 PF11593.3 CDI77275.1 - 3.9e-05 23.0 3.5 3.9e-05 23.0 2.4 21.5 11 5 7 19 19 19 2 Mediator complex subunit 3 fungal Glyco_trans_1_4 PF13692.1 CDI77275.1 - 0.0042 17.2 2.0 0.0063 16.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF4342 PF14242.1 CDI77275.1 - 0.64 9.8 0.1 3 7.6 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) ELO PF01151.13 CDI77277.1 - 7.4e-11 41.8 1.1 8.8e-11 41.5 0.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family YMF19 PF02326.10 CDI77277.1 - 0.029 14.9 0.6 0.19 12.3 0.1 2.3 2 0 0 2 2 2 0 Plant ATP synthase F0 Zip PF02535.17 CDI77277.1 - 0.053 12.5 2.8 0.031 13.2 0.5 1.6 1 1 1 2 2 2 0 ZIP Zinc transporter PI3_PI4_kinase PF00454.22 CDI77278.1 - 2.5e-09 36.9 0.0 4.5e-08 32.8 0.0 2.4 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase NUC194 PF08163.7 CDI77278.1 - 0.041 12.7 0.0 9.3 4.9 0.0 2.7 2 0 0 2 2 2 0 NUC194 domain E1-E2_ATPase PF00122.15 CDI77279.1 - 1e-15 57.3 0.0 1e-15 57.3 0.0 3.9 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 CDI77279.1 - 5e-15 56.4 0.4 2.8e-11 44.2 2.1 7.2 6 2 0 6 6 6 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDI77279.1 - 4.2e-10 40.1 0.0 4.2e-09 36.8 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase KASH PF10541.4 CDI77279.1 - 1.2 9.0 11.0 0.011 15.5 1.4 2.4 2 0 0 2 2 2 0 Nuclear envelope localisation domain Macoilin PF09726.4 CDI77280.1 - 0.052 11.8 3.2 0.061 11.6 2.2 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF2051 PF09738.4 CDI77280.1 - 8.8 5.5 8.9 8.1 5.6 5.2 1.6 2 0 0 2 2 2 0 Double stranded RNA binding protein (DUF2051) Myosin_head PF00063.16 CDI77282.1 - 3.7e-150 501.2 8.6 1.8e-118 396.4 3.1 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) SR-25 PF10500.4 CDI77282.1 - 0.48 9.8 41.3 0.85 9.0 5.7 3.7 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Activator_LAG-3 PF11498.3 CDI77282.1 - 2.1 6.9 36.2 0.68 8.6 14.2 2.7 2 0 0 2 2 2 0 Transcriptional activator LAG-3 FimP PF09766.4 CDI77282.1 - 4.3 6.3 16.4 0.094 11.7 5.5 2.1 2 0 0 2 2 2 0 Fms-interacting protein RAB3GAP2_N PF14655.1 CDI77282.1 - 6.6 5.6 13.2 0.093 11.7 3.2 2.0 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1459 PF07312.6 CDI77284.1 - 0.052 13.4 0.3 0.052 13.4 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1459) TPR_11 PF13414.1 CDI77285.1 - 0.00018 21.0 0.6 0.00043 19.8 0.4 1.6 1 0 0 1 1 1 1 TPR repeat Peptidase_C97 PF05903.9 CDI77286.1 - 2.1e-06 27.5 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain LURAP PF14854.1 CDI77286.1 - 0.25 11.0 6.4 0.4 10.3 4.5 1.3 1 0 0 1 1 1 0 Leucine rich adaptor protein Med15 PF09606.5 CDI77286.1 - 0.6 8.2 23.9 0.73 7.9 16.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal FUSC PF04632.7 CDI77286.1 - 2.4 6.4 9.1 3.3 6.0 6.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6 PF04111.7 CDI77286.1 - 3.8 6.4 12.3 4.8 6.1 8.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF572 PF04502.8 CDI77286.1 - 5.8 6.0 14.7 8.2 5.5 10.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_C97 PF05903.9 CDI77287.1 - 1.6e-14 53.9 0.0 2.2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF2514 PF10721.4 CDI77287.1 - 7.5 6.2 23.0 9.9 5.8 15.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) ETRAMP PF09716.5 CDI77288.1 - 0.13 12.1 0.0 0.13 12.1 0.0 3.9 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) NiFeSe_Hases PF00374.14 CDI77289.1 - 0.02 13.6 0.8 0.033 12.9 0.6 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase DUF4647 PF15504.1 CDI77289.1 - 0.16 10.8 7.1 0.24 10.1 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Exostosin PF03016.10 CDI77289.1 - 0.66 8.9 5.9 0.12 11.4 0.7 2.0 2 0 0 2 2 2 0 Exostosin family DUF4557 PF15101.1 CDI77289.1 - 1.6 8.4 11.2 4.4 7.0 7.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) RAB3GAP2_N PF14655.1 CDI77290.1 - 0.023 13.7 0.1 0.023 13.7 0.1 4.4 2 1 2 4 4 4 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Neurensin PF14927.1 CDI77291.1 - 0.006 15.9 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 Neurensin DUF624 PF04854.9 CDI77291.1 - 0.021 14.6 0.1 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF624 DUF2371 PF10177.4 CDI77291.1 - 0.057 13.3 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF1206 PF06724.6 CDI77291.1 - 0.43 10.3 3.0 0.19 11.5 0.6 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) RAP1 PF07218.6 CDI77296.1 - 0.081 11.0 17.6 0.2 9.7 2.3 2.0 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Ndc1_Nup PF09531.5 CDI77296.1 - 0.33 9.3 8.5 0.36 9.1 5.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DNA_pol_viral_N PF00242.12 CDI77296.1 - 0.78 8.7 13.4 1.5 7.7 9.3 1.5 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Dicty_REP PF05086.7 CDI77296.1 - 7 4.2 12.3 9.7 3.7 8.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PCI PF01399.22 CDI77298.1 - 2e-16 60.2 4.1 7.7e-16 58.3 0.1 2.4 2 0 0 2 2 2 1 PCI domain Mad3_BUB1_I PF08311.7 CDI77298.1 - 0.049 13.4 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 DUF1908 PF08926.6 CDI77298.1 - 1.5 7.4 5.0 3.8 6.1 3.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1908) Ribosomal_60s PF00428.14 CDI77298.1 - 4 7.9 51.4 0.11 12.9 7.7 3.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein Di19_C PF14571.1 CDI77299.1 - 0.0013 19.0 2.3 0.0015 18.7 1.6 1.1 1 0 0 1 1 1 1 Stress-induced protein Di19, C-terminal DUF4355 PF14265.1 CDI77299.1 - 0.004 17.0 11.2 0.0051 16.7 7.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4355) NARP1 PF12569.3 CDI77299.1 - 0.032 13.0 4.2 0.035 12.8 2.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM176 PF14851.1 CDI77299.1 - 0.032 13.9 1.3 0.036 13.7 0.9 1.2 1 0 0 1 1 1 0 FAM176 family D123 PF07065.9 CDI77299.1 - 0.047 12.7 0.6 0.047 12.7 0.4 1.0 1 0 0 1 1 1 0 D123 DUF3371 PF11851.3 CDI77299.1 - 0.052 14.2 7.7 0.054 14.1 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) TMEM154 PF15102.1 CDI77299.1 - 0.053 13.2 1.5 0.06 13.0 1.1 1.1 1 0 0 1 1 1 0 TMEM154 protein family Peptidase_C58 PF03543.9 CDI77299.1 - 0.062 12.7 6.7 0.067 12.6 4.6 1.0 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen PAT1 PF09770.4 CDI77299.1 - 0.073 11.3 15.0 0.074 11.2 10.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FHIPEP PF00771.15 CDI77299.1 - 0.083 11.2 1.8 0.092 11.0 1.2 1.0 1 0 0 1 1 1 0 FHIPEP family Spt20 PF12090.3 CDI77299.1 - 0.11 11.8 5.0 0.11 11.8 3.5 1.1 1 0 0 1 1 1 0 Spt20 family FimP PF09766.4 CDI77299.1 - 0.11 11.5 12.2 0.13 11.3 8.4 1.0 1 0 0 1 1 1 0 Fms-interacting protein RP-C_C PF11800.3 CDI77299.1 - 0.14 11.8 5.0 0.17 11.5 3.4 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Med15 PF09606.5 CDI77299.1 - 0.16 10.1 23.7 0.16 10.1 16.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2407 PF10302.4 CDI77299.1 - 0.24 11.5 2.7 0.33 11.1 1.8 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain INTS2 PF14750.1 CDI77299.1 - 0.3 8.5 6.5 0.31 8.4 4.5 1.0 1 0 0 1 1 1 0 Integrator complex subunit 2 LIM_bind PF01803.11 CDI77299.1 - 0.34 9.9 6.1 0.37 9.8 4.2 1.1 1 0 0 1 1 1 0 LIM-domain binding protein Radial_spoke PF04712.7 CDI77299.1 - 0.42 9.3 7.3 0.51 9.0 5.1 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein Suf PF05843.9 CDI77299.1 - 0.43 10.2 8.9 0.47 10.1 6.2 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) 60KD_IMP PF02096.15 CDI77299.1 - 0.44 10.1 10.4 0.48 10.0 7.2 1.1 1 0 0 1 1 1 0 60Kd inner membrane protein DUF912 PF06024.7 CDI77299.1 - 0.51 10.4 2.2 0.63 10.1 1.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4175 PF13779.1 CDI77299.1 - 0.7 7.5 21.0 0.75 7.4 14.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EIIBC-GUT_N PF03612.9 CDI77299.1 - 0.8 9.2 3.2 0.92 9.0 2.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4557 PF15101.1 CDI77299.1 - 0.81 9.4 11.6 0.89 9.3 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) TMEM51 PF15345.1 CDI77299.1 - 1.1 8.9 8.4 1.3 8.6 5.8 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 OATP PF03137.15 CDI77299.1 - 1.2 7.0 4.3 1.4 6.9 3.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RED_N PF07808.8 CDI77299.1 - 1.4 8.0 12.3 1.8 7.7 8.6 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF106 PF01956.11 CDI77299.1 - 1.6 8.2 4.5 1.7 8.1 3.1 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 Gag_spuma PF03276.9 CDI77299.1 - 1.9 6.7 12.3 2.2 6.4 8.5 1.2 1 0 0 1 1 1 0 Spumavirus gag protein MscS_TM PF12794.2 CDI77299.1 - 3 6.3 7.5 3.5 6.1 5.2 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF775 PF05603.7 CDI77299.1 - 4.5 6.7 7.7 5.3 6.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Serinc PF03348.10 CDI77299.1 - 4.9 5.7 6.3 5.7 5.5 4.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) OmpH PF03938.9 CDI77299.1 - 5.5 6.9 23.2 6.8 6.6 16.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SseC PF04888.7 CDI77299.1 - 8.6 5.5 16.1 9.6 5.4 11.2 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family MMR_HSR1 PF01926.18 CDI77300.1 - 4.7e-05 23.3 0.1 0.00017 21.5 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase RhoGEF PF00621.15 CDI77300.1 - 0.0021 17.9 0.7 0.0029 17.5 0.5 1.2 1 0 0 1 1 1 1 RhoGEF domain Dynamin_N PF00350.18 CDI77300.1 - 0.025 14.3 0.1 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 Dynamin family Vps16_N PF04841.8 CDI77302.1 - 5.9e-06 25.0 0.1 5.9e-06 25.0 0.0 1.0 1 0 0 1 1 1 1 Vps16, N-terminal region PNP_UDP_1 PF01048.15 CDI77303.1 - 5.8e-20 71.2 0.0 7e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily CAF-1_p150 PF11600.3 CDI77305.1 - 0.0025 17.2 30.8 0.0029 17.0 21.4 1.2 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal SprA-related PF12118.3 CDI77305.1 - 0.057 12.7 45.7 0.06 12.6 31.7 1.1 1 0 0 1 1 1 0 SprA-related family SR-25 PF10500.4 CDI77305.1 - 0.11 11.9 37.1 0.17 11.3 25.7 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2052 PF09747.4 CDI77305.1 - 0.2 11.5 24.7 0.24 11.3 17.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DDRGK PF09756.4 CDI77305.1 - 0.59 9.5 26.5 0.81 9.0 18.4 1.2 1 0 0 1 1 1 0 DDRGK domain DUF2486 PF10667.4 CDI77305.1 - 0.79 10.2 12.8 0.9 10.0 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) Raftlin PF15250.1 CDI77305.1 - 0.79 8.1 22.0 0.87 8.0 15.2 1.1 1 0 0 1 1 1 0 Raftlin Asp-B-Hydro_N PF05279.6 CDI77305.1 - 1.3 8.7 15.2 1.4 8.6 10.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4045 PF13254.1 CDI77305.1 - 1.5 7.9 27.7 1.7 7.8 19.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) LicD PF04991.8 CDI77305.1 - 1.7 8.6 5.6 2.3 8.2 3.9 1.3 1 0 0 1 1 1 0 LicD family Tim54 PF11711.3 CDI77305.1 - 1.8 7.0 15.1 2.1 6.8 10.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3337 PF11816.3 CDI77305.1 - 2 7.6 19.5 2.6 7.3 13.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) DUF2561 PF10812.3 CDI77305.1 - 2.1 7.8 6.8 2.6 7.6 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF4175 PF13779.1 CDI77305.1 - 2.3 5.8 48.0 2.2 5.8 33.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Corona_nucleoca PF00937.13 CDI77305.1 - 2.7 6.8 35.1 3.4 6.5 24.3 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF853 PF05872.7 CDI77305.1 - 3.8 5.7 14.4 4.3 5.5 10.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Glyco_transf_6 PF03414.8 CDI77305.1 - 7 5.0 11.0 8.3 4.7 7.6 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 6 SOBP PF15279.1 CDI77305.1 - 7.9 6.7 34.3 8.7 6.6 23.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein PPP4R2 PF09184.6 CDI77305.1 - 8 5.9 22.5 11 5.4 15.6 1.2 1 0 0 1 1 1 0 PPP4R2 Macoilin PF09726.4 CDI77307.1 - 2.3 6.3 22.4 3 6.0 15.6 1.1 1 0 0 1 1 1 0 Transmembrane protein PAT1 PF09770.4 CDI77307.1 - 3.7 5.6 24.8 4.8 5.2 17.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MCM PF00493.18 CDI77314.1 - 3.7e-92 308.6 0.1 7.4e-91 304.3 0.0 2.4 1 1 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 CDI77314.1 - 7.5e-07 28.5 0.1 0.00043 19.5 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI MCM_N PF14551.1 CDI77314.1 - 0.00031 21.2 0.0 0.0011 19.4 0.0 2.0 1 0 0 1 1 1 1 MCM N-terminal domain AAA_3 PF07726.6 CDI77314.1 - 0.00084 18.9 0.2 0.0082 15.7 0.0 2.9 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI77314.1 - 0.0061 16.2 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF572 PF04502.8 CDI77315.1 - 0.012 14.8 14.9 0.015 14.5 10.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Cwf_Cwc_15 PF04889.7 CDI77315.1 - 0.022 14.5 18.1 0.04 13.6 12.6 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HD-ZIP_N PF04618.7 CDI77315.1 - 0.16 12.5 17.0 0.13 12.8 5.3 2.1 2 0 0 2 2 2 0 HD-ZIP protein N terminus SpoIIIAH PF12685.2 CDI77315.1 - 0.33 10.4 13.2 0.4 10.1 9.1 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Pex14_N PF04695.8 CDI77315.1 - 0.34 10.9 29.6 1.5 8.8 7.0 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1570 PF07607.6 CDI77315.1 - 1.1 9.3 6.9 0.11 12.4 1.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1570) DUF966 PF06136.8 CDI77315.1 - 1.1 8.6 16.4 1.4 8.2 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF1266 PF06889.6 CDI77315.1 - 1.9 8.2 9.2 1.1 9.0 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) DUF2370 PF10176.4 CDI77315.1 - 5.6 6.2 10.3 4.2 6.6 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) RIC3 PF15361.1 CDI77315.1 - 6.2 7.0 13.5 3.1 8.0 2.3 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 SR-25 PF10500.4 CDI77315.1 - 6.4 6.1 24.0 4.3 6.7 13.7 1.9 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein SAE2 PF08573.5 CDI77315.1 - 8.2 7.2 9.2 9.6 6.9 1.0 2.2 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus ketoacyl-synt PF00109.21 CDI77317.1 - 1.8e-43 148.8 0.6 1.8e-43 148.8 0.4 6.3 6 0 0 6 6 6 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.23 CDI77317.1 - 7.2e-42 143.2 0.0 5.4e-26 90.9 0.0 3.2 2 1 0 2 2 2 2 AMP-binding enzyme Ketoacyl-synt_C PF02801.17 CDI77317.1 - 7.3e-19 67.7 3.1 2.6e-15 56.3 0.2 5.9 5 0 0 5 5 5 2 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 CDI77317.1 - 2.5e-06 27.6 0.0 7.4e-05 22.9 0.1 2.6 2 0 0 2 2 2 1 Phosphopantetheine attachment site OmpH PF03938.9 CDI77317.1 - 0.028 14.3 0.0 0.032 14.1 0.2 13.4 10 6 0 11 11 11 0 Outer membrane protein (OmpH-like) Helicase_C PF00271.26 CDI77319.1 - 1.3e-10 40.9 0.0 1.3e-10 40.9 0.0 5.0 6 0 0 6 6 6 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDI77319.1 - 3.2e-05 23.4 0.2 3.2e-05 23.4 0.1 4.9 3 2 1 4 4 4 1 DEAD/DEAH box helicase SPX PF03105.14 CDI77319.1 - 0.0033 17.2 0.1 0.0033 17.2 0.1 5.6 2 1 2 4 4 4 1 SPX domain Ycf1 PF05758.7 CDI77320.1 - 0.0016 16.2 10.3 0.0019 16.0 7.2 1.1 1 0 0 1 1 1 1 Ycf1 Baculo_PP31 PF05311.6 CDI77320.1 - 0.023 13.9 6.7 0.045 13.0 4.6 1.6 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CDC45 PF02724.9 CDI77320.1 - 0.13 10.2 18.3 0.0085 14.1 8.8 1.8 2 0 0 2 2 2 0 CDC45-like protein SPX PF03105.14 CDI77320.1 - 0.49 10.1 17.0 0.024 14.4 7.1 2.1 2 1 0 2 2 2 0 SPX domain Mem_trans PF03547.13 CDI77320.1 - 1.7 6.8 5.4 2.7 6.1 3.7 1.4 1 0 0 1 1 1 0 Membrane transport protein SID-1_RNA_chan PF13965.1 CDI77320.1 - 5 5.1 6.0 6.9 4.7 4.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Otopetrin PF03189.8 CDI77320.1 - 7.6 5.4 5.8 14 4.5 4.0 1.4 1 0 0 1 1 1 0 Otopetrin Peptidase_U57 PF05582.7 CDI77320.1 - 8.2 5.2 8.8 15 4.4 6.1 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Adap_comp_sub PF00928.16 CDI77323.1 - 2.2e-26 92.5 0.0 2.6e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family SNF2_N PF00176.18 CDI77325.1 - 4e-72 242.5 2.9 4e-72 242.5 2.0 3.5 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDI77325.1 - 1.6e-10 40.7 0.1 1.6e-10 40.7 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ubiq_cyt_C_chap PF03981.7 CDI77328.1 - 2.8 7.7 9.5 2.1 8.2 0.1 2.5 2 1 0 2 2 2 0 Ubiquinol-cytochrome C chaperone SpvB PF03534.8 CDI77328.1 - 8.5 5.2 8.6 17 4.3 5.9 1.7 1 1 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein mRNA_triPase PF02940.10 CDI77329.1 - 6.5e-14 52.1 0.0 2.7e-07 30.5 0.0 3.2 2 1 0 2 2 2 2 mRNA capping enzyme, beta chain DUF601 PF04642.7 CDI77330.1 - 0.32 10.3 6.7 0.37 10.1 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DUF702 PF05142.7 CDI77330.1 - 0.85 9.7 7.4 0.94 9.6 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) TMEM51 PF15345.1 CDI77330.1 - 1.3 8.6 8.8 1.5 8.4 6.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Pex16 PF08610.5 CDI77330.1 - 2.4 7.0 7.1 2.2 7.1 5.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) TFIIA PF03153.8 CDI77330.1 - 2.4 7.9 19.7 2.8 7.7 13.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fig1 PF12351.3 CDI77330.1 - 2.6 7.9 5.3 3.1 7.6 3.7 1.1 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 SAGA-Tad1 PF12767.2 CDI77330.1 - 2.9 7.4 10.9 4 7.0 7.6 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit CDK5_activator PF03261.10 CDI77330.1 - 5 6.3 8.3 4.6 6.4 5.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Hid1 PF12722.2 CDI77330.1 - 5.1 4.6 7.6 4.5 4.8 5.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_M22 PF00814.20 CDI77331.1 - 7e-20 71.6 28.3 7.5e-07 28.9 0.1 6.8 7 1 0 7 7 7 6 Glycoprotease family SPX PF03105.14 CDI77331.1 - 0.00011 22.0 2.6 0.00011 22.0 1.8 4.7 3 1 1 4 4 4 1 SPX domain RED_N PF07808.8 CDI77331.1 - 0.00065 18.9 6.2 0.00065 18.9 4.3 5.6 5 1 0 5 5 5 1 RED-like protein N-terminal region SprA-related PF12118.3 CDI77331.1 - 0.0038 16.5 28.5 0.0038 16.5 19.8 6.9 4 2 1 6 6 6 2 SprA-related family SAGA-Tad1 PF12767.2 CDI77331.1 - 0.28 10.8 59.4 0.5 9.9 9.3 5.1 5 0 0 5 5 5 0 Transcriptional regulator of RNA polII, SAGA, subunit Tim54 PF11711.3 CDI77331.1 - 5.5 5.4 27.6 1.1 7.7 6.4 3.9 4 0 0 4 4 4 0 Inner membrane protein import complex subunit Tim54 Motile_Sperm PF00635.21 CDI77332.1 - 7e-20 70.6 0.0 1.1e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain SR-25 PF10500.4 CDI77332.1 - 0.016 14.6 4.3 0.023 14.1 3.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Serglycin PF04360.7 CDI77332.1 - 1.3 8.6 5.7 3 7.5 4.0 1.8 1 1 0 1 1 1 0 Serglycin DAO PF01266.19 CDI77333.1 - 5.3e-09 35.4 0.1 1.7e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase UCH PF00443.24 CDI77336.1 - 4.4e-26 91.5 0.0 9.8e-24 83.8 0.0 3.8 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_60s PF00428.14 CDI77337.1 - 0.0035 17.6 1.0 0.0035 17.6 0.7 8.7 7 4 2 9 9 9 1 60s Acidic ribosomal protein PRAP PF15314.1 CDI77338.1 - 0.18 12.1 2.6 0.41 10.9 1.8 1.6 1 0 0 1 1 1 0 Proline-rich acidic protein 1, pregnancy-specific uterine Activator_LAG-3 PF11498.3 CDI77338.1 - 0.54 8.9 19.4 0.018 13.8 5.8 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Arm PF00514.18 CDI77339.1 - 0.037 13.8 0.1 0.31 10.9 0.0 2.5 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Fumerase_C PF05683.7 CDI77340.1 - 2.8e-71 238.9 0.0 3e-71 238.7 0.0 1.0 1 0 0 1 1 1 1 Fumarase C-terminus Pox_Ag35 PF03286.9 CDI77342.1 - 4.8 6.6 21.1 5.3 6.5 14.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TFIIA PF03153.8 CDI77343.1 - 0.028 14.3 9.6 0.034 14.0 6.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF702 PF05142.7 CDI77343.1 - 0.097 12.8 2.3 0.13 12.3 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) SDA1 PF05285.7 CDI77343.1 - 0.2 10.9 12.7 0.25 10.5 8.8 1.2 1 0 0 1 1 1 0 SDA1 BNIP3 PF06553.7 CDI77343.1 - 0.29 10.4 10.8 0.41 9.9 7.5 1.2 1 0 0 1 1 1 0 BNIP3 Cwf_Cwc_15 PF04889.7 CDI77343.1 - 0.73 9.4 17.4 0.16 11.6 10.0 1.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TT_ORF2 PF02957.10 CDI77343.1 - 0.85 10.3 7.1 0.14 12.9 2.5 1.5 2 0 0 2 2 1 0 TT viral ORF2 Nucleo_P87 PF07267.6 CDI77343.1 - 0.88 8.1 9.5 1.3 7.6 6.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Astro_capsid PF03115.9 CDI77343.1 - 1 7.5 6.6 1.2 7.3 4.6 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor PA26 PF04636.8 CDI77343.1 - 1 7.9 3.6 1.1 7.8 2.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Fmp27 PF10344.4 CDI77343.1 - 1.1 6.8 6.6 1.3 6.5 4.6 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Presenilin PF01080.12 CDI77343.1 - 1.5 7.5 4.6 1.9 7.2 3.2 1.1 1 0 0 1 1 1 0 Presenilin LAT PF15234.1 CDI77343.1 - 1.8 8.0 10.5 3 7.2 7.3 1.5 1 1 0 1 1 1 0 Linker for activation of T-cells PPP4R2 PF09184.6 CDI77343.1 - 1.8 8.0 17.5 0.33 10.4 9.9 1.3 2 0 0 2 2 2 0 PPP4R2 BTV_NS2 PF04514.7 CDI77343.1 - 2.3 6.9 8.4 3.1 6.5 5.8 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF4175 PF13779.1 CDI77343.1 - 3.2 5.3 15.9 3.9 5.0 11.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FLO_LFY PF01698.11 CDI77343.1 - 4.1 6.1 8.5 5.5 5.7 5.9 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Hid1 PF12722.2 CDI77343.1 - 4.2 4.9 7.2 4.3 4.8 5.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.9 CDI77343.1 - 5.2 4.9 11.3 5.8 4.8 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.11 CDI77343.1 - 6.4 6.1 7.6 9.5 5.5 5.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 F-protein PF00469.15 CDI77343.1 - 9.1 5.5 9.7 13 5.0 6.7 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF4611 PF15387.1 CDI77343.1 - 9.4 6.4 13.6 6.8 6.9 6.7 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4611) SNF2_N PF00176.18 CDI77344.1 - 0.0052 15.6 0.0 0.011 14.5 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain EPL1 PF10513.4 CDI77345.1 - 0.11 12.7 2.1 0.18 12.0 0.4 1.9 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF4569 PF15133.1 CDI77345.1 - 0.16 11.3 8.8 0.021 14.2 2.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) PHD_3 PF13922.1 CDI77345.1 - 1.2 9.4 5.6 11 6.2 1.2 2.7 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx SR-25 PF10500.4 CDI77345.1 - 2.9 7.3 11.9 0.6 9.5 4.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Pex14_N PF04695.8 CDI77345.1 - 9.2 6.3 12.8 10 6.1 0.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3446 PF11928.3 CDI77345.1 - 9.4 6.5 15.3 20 5.4 6.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) ECH PF00378.15 CDI77347.1 - 9.2e-15 54.4 20.0 9e-14 51.1 13.9 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family zf-DHHC PF01529.15 CDI77347.1 - 0.027 13.8 1.7 0.037 13.4 1.2 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase FimP PF09766.4 CDI77347.1 - 0.038 13.0 23.1 0.054 12.5 16.0 1.3 1 0 0 1 1 1 0 Fms-interacting protein PAT1 PF09770.4 CDI77347.1 - 0.083 11.1 34.9 0.1 10.7 24.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4557 PF15101.1 CDI77347.1 - 0.12 12.1 23.8 0.17 11.6 16.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) eIF-3_zeta PF05091.7 CDI77347.1 - 0.14 10.7 17.3 0.15 10.6 12.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDHD PF02862.12 CDI77347.1 - 0.17 11.6 13.0 0.23 11.2 9.0 1.1 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.5 CDI77347.1 - 0.21 9.7 48.3 0.25 9.5 33.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI77347.1 - 0.21 11.2 16.5 0.29 10.8 11.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hid1 PF12722.2 CDI77347.1 - 0.35 8.4 16.7 0.41 8.2 11.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gti1_Pac2 PF09729.4 CDI77347.1 - 0.37 10.6 8.7 0.49 10.2 6.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family OATP PF03137.15 CDI77347.1 - 0.52 8.2 10.7 0.71 7.8 7.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SprA-related PF12118.3 CDI77347.1 - 0.64 9.2 36.1 0.85 8.8 25.1 1.1 1 0 0 1 1 1 0 SprA-related family Pex14_N PF04695.8 CDI77347.1 - 0.89 9.6 24.5 1.3 9.0 17.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RP-C_C PF11800.3 CDI77347.1 - 1.4 8.5 14.4 1.9 8.1 10.0 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4220 PF13968.1 CDI77347.1 - 1.6 7.7 5.8 1.9 7.4 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) AAA_23 PF13476.1 CDI77347.1 - 1.9 8.7 19.0 2.5 8.3 13.2 1.2 1 0 0 1 1 1 0 AAA domain AIF_C PF14721.1 CDI77347.1 - 2.1 8.5 13.7 3.3 7.9 9.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF2215 PF10225.4 CDI77347.1 - 2.3 7.5 6.1 3.1 7.1 4.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Ctr PF04145.10 CDI77347.1 - 2.4 8.1 7.5 3.9 7.5 5.2 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Zip PF02535.17 CDI77347.1 - 2.7 6.8 7.4 4.3 6.2 5.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter AUX_IAA PF02309.11 CDI77347.1 - 2.9 7.5 13.0 3.6 7.2 9.0 1.2 1 0 0 1 1 1 0 AUX/IAA family SID-1_RNA_chan PF13965.1 CDI77347.1 - 3.5 5.6 7.7 3.7 5.5 5.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.7 CDI77347.1 - 3.6 7.4 16.8 4.4 7.1 11.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OmpH PF03938.9 CDI77347.1 - 3.8 7.4 35.0 4.9 7.0 24.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Asp-B-Hydro_N PF05279.6 CDI77347.1 - 4 7.2 15.8 5.1 6.8 11.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Serinc PF03348.10 CDI77347.1 - 4.2 5.9 13.5 5.6 5.5 9.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MDFI PF15316.1 CDI77347.1 - 6.2 6.7 9.2 13 5.7 6.4 1.5 1 0 0 1 1 1 0 MyoD family inhibitor Band_3_cyto PF07565.8 CDI77347.1 - 6.5 6.1 16.8 9.6 5.6 11.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3533 PF12051.3 CDI77347.1 - 7.1 5.2 10.5 10 4.7 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) EIIBC-GUT_N PF03612.9 CDI77347.1 - 7.4 6.1 12.4 11 5.6 8.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Neur_chan_memb PF02932.11 CDI77347.1 - 7.7 6.3 9.8 9.2 6.0 6.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Gag_spuma PF03276.9 CDI77347.1 - 7.8 4.6 32.4 11 4.2 22.4 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Folate_carrier PF01770.13 CDI77347.1 - 9.5 4.6 10.7 13 4.1 7.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier V-ATPase_C PF03223.10 CDI77348.1 - 1.9e-91 306.7 0.0 2.1e-91 306.6 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C TetR_C_6 PF13977.1 CDI77348.1 - 0.03 14.3 0.9 0.063 13.3 0.6 1.4 1 0 0 1 1 1 0 Bacterial transcriptional repressor DEAD PF00270.24 CDI77349.1 - 3.5e-47 160.0 0.0 6.6e-47 159.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI77349.1 - 1.2e-27 95.5 0.0 2.7e-27 94.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 CDI77349.1 - 0.00079 17.9 0.0 0.0065 14.9 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) AAA_22 PF13401.1 CDI77349.1 - 0.073 13.2 0.4 1.1 9.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain Ssl1 PF04056.9 CDI77351.1 - 2.7e-28 98.8 0.1 1e-27 97.0 0.0 1.9 1 1 0 1 1 1 1 Ssl1-like VWA_2 PF13519.1 CDI77351.1 - 6.8e-07 29.5 0.0 1.1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain SGT1 PF07093.6 CDI77351.1 - 0.0079 14.6 6.7 0.0091 14.4 4.6 1.1 1 0 0 1 1 1 1 SGT1 protein HlyD_2 PF12700.2 CDI77351.1 - 0.11 11.5 7.5 0.14 11.2 5.2 1.2 1 0 0 1 1 1 0 HlyD family secretion protein PAT1 PF09770.4 CDI77351.1 - 0.2 9.8 22.1 0.24 9.6 15.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI77351.1 - 0.2 9.3 5.7 0.21 9.2 3.9 1.1 1 0 0 1 1 1 0 Ycf1 FCP1_C PF09309.5 CDI77351.1 - 0.77 9.0 13.3 1.4 8.1 9.2 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Tfb4 PF03850.9 CDI77351.1 - 0.81 8.8 10.4 1.9 7.6 0.0 2.1 2 0 0 2 2 2 0 Transcription factor Tfb4 DUF912 PF06024.7 CDI77351.1 - 0.94 9.5 6.8 1.8 8.6 4.7 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Neur_chan_memb PF02932.11 CDI77351.1 - 1 9.1 4.3 1.3 8.9 3.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MAT1 PF06391.8 CDI77351.1 - 1.1 8.8 17.3 1.5 8.3 12.0 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 FAM60A PF15396.1 CDI77351.1 - 1.1 8.9 8.2 1.5 8.5 5.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A TFIIA PF03153.8 CDI77351.1 - 1.9 8.2 21.6 2.4 7.9 15.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM51 PF15345.1 CDI77351.1 - 3.6 7.2 12.6 4.8 6.7 8.8 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 PEX11 PF05648.9 CDI77351.1 - 3.6 6.7 9.2 6.6 5.9 6.4 1.4 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) FimP PF09766.4 CDI77351.1 - 4 6.4 20.1 5.5 5.9 13.9 1.3 1 0 0 1 1 1 0 Fms-interacting protein Membralin PF09746.4 CDI77351.1 - 5.5 5.9 8.6 7.9 5.4 5.9 1.2 1 0 0 1 1 1 0 Tumour-associated protein SAE2 PF08573.5 CDI77351.1 - 7.1 7.4 9.2 15 6.3 6.4 1.5 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Adaptin_N PF01602.15 CDI77352.1 - 2.2e-46 158.2 0.0 2.2e-46 158.2 0.0 1.8 2 0 0 2 2 1 1 Adaptin N terminal region B2-adapt-app_C PF09066.5 CDI77352.1 - 2.9e-13 49.6 0.1 2.9e-13 49.6 0.0 2.4 1 1 1 2 2 1 1 Beta2-adaptin appendage, C-terminal sub-domain SID-1_RNA_chan PF13965.1 CDI77352.1 - 0.00097 17.4 3.9 0.00097 17.4 2.7 1.6 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 GAGA_bind PF06217.7 CDI77352.1 - 0.0071 16.3 11.3 0.032 14.2 3.7 2.1 2 0 0 2 2 2 1 GAGA binding protein-like family HEAT_2 PF13646.1 CDI77352.1 - 0.015 15.5 0.6 0.015 15.5 0.4 3.4 4 1 0 4 4 2 0 HEAT repeats PAT1 PF09770.4 CDI77352.1 - 0.039 12.2 34.7 0.27 9.4 2.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DDHD PF02862.12 CDI77352.1 - 0.05 13.4 16.1 0.099 12.4 4.2 2.4 2 0 0 2 2 2 0 DDHD domain DUF737 PF05300.6 CDI77352.1 - 0.081 12.8 25.0 0.031 14.2 3.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF737) FAM60A PF15396.1 CDI77352.1 - 0.12 12.1 16.2 0.92 9.2 5.0 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF4366 PF14283.1 CDI77352.1 - 0.23 10.8 6.9 0.018 14.4 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Ycf1 PF05758.7 CDI77352.1 - 0.23 9.1 11.4 0.43 8.2 5.3 2.0 2 0 0 2 2 2 0 Ycf1 Band_3_cyto PF07565.8 CDI77352.1 - 0.27 10.7 14.4 0.096 12.1 3.6 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Serinc PF03348.10 CDI77352.1 - 0.28 9.8 9.7 0.27 9.9 2.6 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) SprA-related PF12118.3 CDI77352.1 - 0.29 10.4 44.0 1.4 8.1 21.5 2.2 2 0 0 2 2 2 0 SprA-related family LMBR1 PF04791.11 CDI77352.1 - 0.32 9.5 11.7 0.019 13.5 3.6 1.9 2 0 0 2 2 2 0 LMBR1-like membrane protein UPF0564 PF10595.4 CDI77352.1 - 0.35 9.7 31.7 0.13 11.1 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 TFIIA PF03153.8 CDI77352.1 - 0.44 10.4 34.8 1.3 8.7 15.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SURF6 PF04935.7 CDI77352.1 - 0.49 9.6 28.5 0.22 10.8 11.8 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 Mem_trans PF03547.13 CDI77352.1 - 1.1 7.5 7.7 2.5 6.3 2.4 2.2 2 0 0 2 2 2 0 Membrane transport protein Presenilin PF01080.12 CDI77352.1 - 1.6 7.5 20.3 0.64 8.7 7.7 2.1 2 0 0 2 2 2 0 Presenilin FLO_LFY PF01698.11 CDI77352.1 - 2.2 7.0 16.3 0.51 9.1 5.4 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein Hid1 PF12722.2 CDI77352.1 - 2.5 5.6 21.6 1.7 6.2 0.9 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Peptidase_S64 PF08192.6 CDI77352.1 - 2.5 6.3 14.8 0.27 9.5 3.1 2.1 2 0 0 2 2 2 0 Peptidase family S64 Plasmodium_Vir PF05795.6 CDI77352.1 - 2.8 7.0 7.1 3.7 6.6 0.3 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF1510 PF07423.6 CDI77352.1 - 2.8 7.2 24.7 0.18 11.1 8.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Pex14_N PF04695.8 CDI77352.1 - 3.6 7.6 29.7 0.17 11.9 9.9 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM91_C PF14648.1 CDI77352.1 - 4 6.1 11.4 0.056 12.2 2.1 2.0 2 0 0 2 2 2 0 FAM91 C-terminus eIF-3_zeta PF05091.7 CDI77352.1 - 4.2 5.8 23.5 3.7 6.0 10.3 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TMEM51 PF15345.1 CDI77352.1 - 4.9 6.7 20.2 1.4 8.5 7.4 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 SAPS PF04499.10 CDI77352.1 - 4.9 5.6 19.8 6.3 5.3 0.2 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein HlyD_2 PF12700.2 CDI77352.1 - 5 6.1 20.5 0.48 9.5 7.1 2.1 2 0 0 2 2 2 0 HlyD family secretion protein Hom_end_hint PF05203.11 CDI77352.1 - 6.2 6.4 15.1 8.6 6.0 5.8 2.3 2 0 0 2 2 2 0 Hom_end-associated Hint Adaptin_N PF01602.15 CDI77353.1 - 1.3e-52 178.8 5.5 3.9e-27 94.7 0.3 2.0 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.2 CDI77353.1 - 1.1e-17 64.4 0.3 5e-17 62.3 0.1 1.9 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CDI77353.1 - 8.1e-11 41.0 0.7 0.0014 18.5 0.0 3.9 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.1 CDI77353.1 - 2.5e-09 37.3 5.1 0.00062 20.0 0.3 3.0 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 CDI77353.1 - 0.0022 18.3 9.9 0.041 14.3 0.1 3.4 2 1 1 3 3 3 2 HEAT-like repeat CLASP_N PF12348.3 CDI77353.1 - 0.0054 16.1 1.1 0.38 10.0 0.0 2.7 2 1 1 3 3 3 1 CLASP N terminal Arm PF00514.18 CDI77353.1 - 0.048 13.5 0.1 0.51 10.2 0.0 2.7 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Tim54 PF11711.3 CDI77354.1 - 2.3 6.7 13.6 3.3 6.2 7.1 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Cellulose_synt PF03552.9 CDI77354.1 - 2.5 6.2 7.5 4.8 5.3 5.2 1.4 1 0 0 1 1 1 0 Cellulose synthase Peptidase_U57 PF05582.7 CDI77354.1 - 2.8 6.8 12.1 7.1 5.5 8.4 1.6 1 0 0 1 1 1 0 YabG peptidase U57 Prefoldin PF02996.12 CDI77355.1 - 0.4 10.3 2.8 15 5.2 0.2 2.7 2 1 1 3 3 3 0 Prefoldin subunit Mog1 PF04603.7 CDI77356.1 - 9.3e-19 67.7 0.0 1.1e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Trypan_PARP PF05887.6 CDI77357.1 - 0.33 10.7 7.5 0.5 10.1 5.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ubiquitin PF00240.18 CDI77358.1 - 1.7e-09 36.9 0.2 8e-07 28.3 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 CDI77358.1 - 0.0045 16.6 0.5 0.013 15.1 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.5 CDI77358.1 - 0.0083 16.6 0.1 0.09 13.3 0.0 2.2 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD IMCp PF12314.3 CDI77359.1 - 9.6e-06 25.6 17.1 9.6e-06 25.6 11.8 3.8 2 1 2 4 4 4 3 Inner membrane complex protein Clathrin PF00637.15 CDI77360.1 - 2.5e-06 27.1 0.3 8.1e-06 25.4 0.1 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.3 CDI77360.1 - 2.5e-05 24.0 0.1 6.2e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal AsnA PF03590.10 CDI77361.1 - 1.9e-75 253.4 0.0 2.4e-75 253.1 0.0 1.1 1 0 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.15 CDI77361.1 - 0.0025 16.6 0.0 0.012 14.3 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) Dabb PF07876.7 CDI77362.1 - 1.8e-21 76.3 0.5 2e-21 76.2 0.4 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Ribosomal_L24e PF01246.15 CDI77363.1 - 2.5e-20 72.0 0.8 5e-20 71.1 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e Trigger_C PF05698.9 CDI77364.1 - 2e-12 47.2 18.0 2e-12 47.2 12.5 1.6 2 0 0 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus Toxin-JAB1 PF15659.1 CDI77364.1 - 0.01 15.7 0.1 0.022 14.6 0.1 1.6 1 0 0 1 1 1 0 JAB-like toxin 1 Beach PF02138.13 CDI77364.1 - 0.037 13.4 0.7 0.082 12.3 0.5 1.5 1 1 0 1 1 1 0 Beige/BEACH domain DUF758 PF05527.6 CDI77364.1 - 0.12 11.9 2.1 0.37 10.3 1.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF758) CcdA PF07362.7 CDI77364.1 - 2.4 8.0 9.2 1.2 9.0 2.0 2.9 3 1 0 3 3 3 0 Post-segregation antitoxin CcdA EXS PF03124.9 CDI77365.1 - 1.2e-09 37.6 0.1 1.4e-09 37.4 0.1 1.1 1 0 0 1 1 1 1 EXS family 2-oxoacid_dh PF00198.18 CDI77366.1 - 1.7e-67 227.1 0.0 2.1e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CDI77366.1 - 2.1e-19 68.9 0.9 3.9e-19 68.0 0.6 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 CDI77366.1 - 2.2e-17 62.4 2.5 3.9e-17 61.5 0.7 2.3 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 CDI77366.1 - 4e-07 29.6 0.1 1.6e-06 27.6 0.1 2.0 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD PF00529.15 CDI77366.1 - 0.0002 20.7 0.1 0.00033 20.0 0.1 1.3 1 0 0 1 1 1 1 HlyD family secretion protein HlyD_2 PF12700.2 CDI77366.1 - 0.00072 18.8 0.1 0.0012 18.1 0.1 1.4 1 0 0 1 1 1 1 HlyD family secretion protein GCV_H PF01597.14 CDI77366.1 - 0.009 15.6 0.1 0.018 14.7 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein DUF2428 PF10350.4 CDI77368.1 - 2.5e-12 46.3 5.5 5.8e-11 41.9 0.2 3.9 3 1 0 3 3 3 2 Putative death-receptor fusion protein (DUF2428) Neur_chan_memb PF02932.11 CDI77368.1 - 0.92 9.3 12.0 1.8 8.3 0.0 4.3 4 0 0 4 4 4 0 Neurotransmitter-gated ion-channel transmembrane region Bul1_N PF04425.7 CDI77368.1 - 1.7 7.1 2.3 4.7 5.6 1.6 1.7 1 0 0 1 1 1 0 Bul1 N terminus Sec23_trunk PF04811.10 CDI77369.1 - 1.1e-55 188.6 0.0 1.6e-55 188.1 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CDI77369.1 - 1.1e-31 108.3 1.0 2e-31 107.4 0.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 CDI77369.1 - 8.8e-31 106.2 0.1 1.3e-29 102.5 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 CDI77369.1 - 6.7e-15 54.3 3.6 1.3e-14 53.4 2.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 CDI77369.1 - 6.1e-12 45.0 0.0 1.9e-11 43.5 0.0 1.8 1 1 0 1 1 1 1 Gelsolin repeat Rad51 PF08423.6 CDI77370.1 - 4.4e-122 405.9 0.1 1.2e-64 217.6 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.1 CDI77370.1 - 2.4e-11 43.3 0.0 4.4e-10 39.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain HHH_5 PF14520.1 CDI77370.1 - 9.9e-07 28.8 1.2 1.6e-06 28.1 0.2 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain RecA PF00154.16 CDI77370.1 - 3e-06 26.5 0.0 0.00075 18.6 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein KaiC PF06745.8 CDI77370.1 - 0.0003 19.9 0.0 0.0013 17.9 0.0 1.9 2 0 0 2 2 2 1 KaiC PP2C PF00481.16 CDI77371.1 - 1.5e-46 158.8 0.0 1.5e-46 158.8 0.0 3.0 3 1 0 3 3 3 1 Protein phosphatase 2C MIP-T3 PF10243.4 CDI77371.1 - 0.002 16.7 46.7 0.003 16.1 32.4 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 ubiquitin PF00240.18 CDI77374.1 - 0.021 14.2 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family DUF4131 PF13567.1 CDI77374.1 - 0.51 9.7 6.1 0.89 8.9 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Coatomer_WDAD PF04053.9 CDI77375.1 - 8.2e-05 21.5 10.5 0.001 17.9 0.5 4.5 5 0 0 5 5 5 2 Coatomer WD associated region TPR_1 PF00515.23 CDI77375.1 - 0.074 12.6 0.8 36 4.1 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDI77375.1 - 0.49 10.4 19.5 1 9.4 0.2 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI77375.1 - 1.5 8.8 6.8 1.8 8.5 0.2 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Polyketide_cyc2 PF10604.4 CDI77376.1 - 0.24 11.5 1.8 0.57 10.3 1.3 1.6 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Voldacs PF03517.8 CDI77377.1 - 9.4e-17 61.1 0.4 1.2e-16 60.7 0.3 1.1 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Lipase_3 PF01764.20 CDI77378.1 - 9.1e-13 48.0 0.0 1.6e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) FAM181 PF15238.1 CDI77378.1 - 0.4 10.7 6.6 0.039 14.0 0.6 2.1 2 1 0 2 2 2 0 FAM181 Exonuc_VII_L PF02601.10 CDI77381.1 - 0.066 12.3 12.6 0.5 9.4 5.7 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Phage_Coat_A PF05357.8 CDI77381.1 - 0.23 11.0 1.5 15 5.2 0.0 2.4 2 0 0 2 2 2 0 Phage Coat Protein A 4HB_MCP_1 PF12729.2 CDI77381.1 - 0.65 9.3 7.7 1.8 7.8 4.2 2.0 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction DUF3573 PF12097.3 CDI77381.1 - 1.9 6.9 3.4 3.2 6.2 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Filament PF00038.16 CDI77381.1 - 7.6 5.8 25.5 0.024 14.0 3.3 2.8 3 0 0 3 3 3 0 Intermediate filament protein SR-25 PF10500.4 CDI77382.1 - 0.00034 20.1 32.4 0.00047 19.7 22.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AA_permease_N PF08403.5 CDI77382.1 - 0.013 14.8 0.0 0.013 14.8 0.0 2.8 3 1 1 4 4 4 0 Amino acid permease N-terminal DUF1777 PF08648.7 CDI77382.1 - 0.13 12.0 22.6 0.15 11.7 15.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Nucleo_P87 PF07267.6 CDI77382.1 - 0.3 9.7 13.3 0.34 9.5 9.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF1510 PF07423.6 CDI77382.1 - 0.51 9.6 23.8 0.7 9.2 16.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.12 CDI77382.1 - 0.52 10.0 13.4 0.73 9.5 9.3 1.3 1 0 0 1 1 1 0 DDHD domain TATR PF03430.8 CDI77382.1 - 0.56 8.7 15.5 0.64 8.5 10.7 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator DNA_pol_viral_N PF00242.12 CDI77382.1 - 1.5 7.7 15.9 1.9 7.4 11.0 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain IncFII_repA PF02387.10 CDI77382.1 - 1.8 7.6 16.9 2.3 7.3 11.7 1.2 1 0 0 1 1 1 0 IncFII RepA protein family Neur_chan_memb PF02932.11 CDI77382.1 - 2 8.2 7.0 2.4 7.9 4.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GAGA_bind PF06217.7 CDI77382.1 - 2 8.3 15.8 2.6 7.9 10.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2413 PF10310.4 CDI77382.1 - 2.7 6.7 21.7 3.3 6.4 15.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Med19 PF10278.4 CDI77382.1 - 2.8 7.5 32.8 0.81 9.3 20.6 1.5 1 1 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Herpes_DNAp_acc PF04929.7 CDI77382.1 - 6.4 5.6 18.7 8.5 5.2 13.0 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF1168 PF06658.7 CDI77382.1 - 7.1 6.1 37.2 1.4 8.4 23.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1168) Apt1 PF10351.4 CDI77382.1 - 7.6 5.2 19.0 8.5 5.1 13.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain LMBR1 PF04791.11 CDI77382.1 - 8.1 4.9 9.8 8.9 4.7 6.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein MAT1 PF06391.8 CDI77383.1 - 0.0052 16.3 14.4 0.011 15.3 10.0 1.5 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 SR-25 PF10500.4 CDI77383.1 - 7.3 5.9 46.4 0.22 10.9 5.2 3.4 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein CDC27 PF09507.5 CDI77384.1 - 0.0011 18.2 33.7 0.0022 17.2 23.4 1.6 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Ndc1_Nup PF09531.5 CDI77384.1 - 0.72 8.2 11.9 1.1 7.5 8.3 1.6 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spt20 PF12090.3 CDI77384.1 - 1.9 7.7 10.6 1.5 8.1 1.8 2.4 2 0 0 2 2 2 0 Spt20 family PBP1_TM PF14812.1 CDI77384.1 - 3.8 7.8 7.6 2.5 8.4 2.6 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal V_ATPase_I PF01496.14 CDI77385.1 - 3 5.5 5.3 5.5 4.7 3.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AP2 PF00847.15 CDI77387.1 - 0.00014 21.9 0.5 0.00014 21.9 0.4 5.3 6 0 0 6 6 6 1 AP2 domain DUF4448 PF14610.1 CDI77387.1 - 0.16 11.4 1.6 0.31 10.4 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4448) ALS2CR8 PF15299.1 CDI77388.1 - 0.028 14.0 4.0 0.035 13.7 2.8 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Reprolysin_3 PF13582.1 CDI77388.1 - 0.1 13.1 2.4 0.12 12.9 1.7 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SpoIIIAH PF12685.2 CDI77388.1 - 3.9 6.9 7.7 4.4 6.7 5.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein MIP-T3 PF10243.4 CDI77388.1 - 6.1 5.1 8.0 7.4 4.9 5.6 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PAP1 PF08601.5 CDI77388.1 - 9.6 5.7 26.2 12 5.4 18.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 AAA_22 PF13401.1 CDI77390.1 - 7.9e-05 22.8 0.1 0.00024 21.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI77390.1 - 0.00027 20.9 4.1 0.00027 20.9 2.8 3.1 3 1 0 3 3 3 1 AAA ATPase domain ORC4_C PF14629.1 CDI77390.1 - 0.029 13.7 0.2 0.085 12.2 0.0 1.8 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 4 C-terminus T2SE PF00437.15 CDI77390.1 - 0.045 12.6 0.0 0.085 11.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein YchF-GTPase_C PF06071.8 CDI77391.1 - 1e-29 102.0 0.6 4e-29 100.2 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 CDI77391.1 - 7e-17 61.4 0.0 3.7e-16 59.1 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDI77391.1 - 4e-06 26.2 0.0 1.2e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_17 PF13207.1 CDI77391.1 - 0.0081 16.9 0.1 0.81 10.5 0.0 2.7 1 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CDI77391.1 - 0.1 12.4 0.0 0.6 10.0 0.0 2.3 1 1 0 1 1 1 0 AAA domain Spt20 PF12090.3 CDI77391.1 - 0.17 11.2 1.8 0.14 11.5 0.2 1.6 2 0 0 2 2 2 0 Spt20 family Pkinase PF00069.20 CDI77392.1 - 3e-71 239.6 0.0 5.1e-71 238.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77392.1 - 1.3e-35 122.7 0.0 1.9e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI77392.1 - 8e-05 22.4 0.1 8e-05 22.4 0.0 3.3 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 CDI77392.1 - 0.00024 20.1 0.0 0.0018 17.3 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 CDI77392.1 - 0.0024 16.9 0.1 0.0056 15.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 CDI77392.1 - 0.023 14.2 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF2156 PF09924.4 CDI77393.1 - 0.079 11.7 0.5 0.18 10.5 0.3 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2156) WD40_alt PF14077.1 CDI77395.1 - 0.54 9.9 18.7 0.14 11.7 2.3 3.9 4 1 1 5 5 5 0 Alternative WD40 repeat motif IncA PF04156.9 CDI77395.1 - 2.8 7.4 72.7 43 3.6 12.6 4.0 1 1 2 3 3 3 0 IncA protein M16C_assoc PF08367.6 CDI77397.1 - 1.7e-17 63.1 0.0 3.5e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 CDI77397.1 - 1e-14 54.6 0.0 2.6e-12 46.8 0.0 3.3 2 2 1 3 3 3 1 Peptidase M16 inactive domain CTNNBL PF08216.6 CDI77399.1 - 9.4e-15 54.1 2.0 1.2e-14 53.7 1.4 1.2 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear RRM_6 PF14259.1 CDI77399.1 - 0.077 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF3675 PF12428.3 CDI77400.1 - 0.49 10.6 2.6 0.62 10.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) MRP-S31 PF15433.1 CDI77400.1 - 0.93 8.8 13.3 0.92 8.8 9.2 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Otopetrin PF03189.8 CDI77400.1 - 1.2 8.0 4.8 1.3 7.9 3.4 1.0 1 0 0 1 1 1 0 Otopetrin UPF0565 PF10561.4 CDI77400.1 - 1.4 7.7 7.9 1.6 7.5 5.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Dehydrin PF00257.14 CDI77400.1 - 1.4 9.2 10.5 1.4 9.2 7.3 1.1 1 0 0 1 1 1 0 Dehydrin FLO_LFY PF01698.11 CDI77400.1 - 1.7 7.3 8.4 1.7 7.4 5.8 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein AUX_IAA PF02309.11 CDI77400.1 - 2.1 8.0 8.2 2.3 7.8 5.7 1.1 1 0 0 1 1 1 0 AUX/IAA family Gti1_Pac2 PF09729.4 CDI77400.1 - 2.3 8.0 6.4 2.5 7.9 4.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family AIF_C PF14721.1 CDI77400.1 - 2.3 8.4 6.2 2.8 8.2 4.3 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF853 PF05872.7 CDI77400.1 - 2.4 6.3 9.6 2.7 6.2 6.6 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Glyco_transf_15 PF01793.11 CDI77400.1 - 2.6 6.9 7.6 2.7 6.8 5.3 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase DUF1764 PF08576.5 CDI77400.1 - 2.7 8.8 9.9 3.4 8.4 6.9 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Neur_chan_memb PF02932.11 CDI77400.1 - 3.3 7.5 6.8 3.8 7.3 4.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cyto_heme_lyase PF01265.12 CDI77400.1 - 4.1 6.9 10.6 4.2 6.8 7.3 1.0 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase FAM60A PF15396.1 CDI77400.1 - 4.2 7.0 6.8 4.1 7.0 4.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.8 CDI77400.1 - 4.4 6.7 11.9 4.5 6.6 8.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.7 CDI77400.1 - 5.2 5.5 13.6 5.4 5.5 9.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.12 CDI77400.1 - 5.9 5.6 5.6 6 5.5 3.9 1.0 1 0 0 1 1 1 0 Presenilin Na_trans_assoc PF06512.8 CDI77400.1 - 6.4 6.6 8.1 7.4 6.4 5.6 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated WBS_methylT PF12589.3 CDI77400.1 - 6.6 7.3 9.4 10 6.7 6.5 1.4 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome DUF605 PF04652.11 CDI77400.1 - 7.5 5.8 17.1 8.1 5.7 11.9 1.0 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 CDI77400.1 - 7.9 4.5 32.8 7.7 4.6 22.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3464 PF11947.3 CDI77400.1 - 8.1 5.8 7.0 10 5.5 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) CHCH PF06747.8 CDI77401.1 - 0.018 14.9 5.5 3.3 7.7 3.8 2.4 1 1 0 1 1 1 0 CHCH domain Med15 PF09606.5 CDI77401.1 - 0.056 11.6 14.1 0.071 11.2 9.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Rubella_E2 PF05749.6 CDI77401.1 - 0.45 9.7 6.4 0.13 11.4 0.4 2.0 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 Cmc1 PF08583.5 CDI77401.1 - 0.52 10.1 4.8 2.3 8.0 1.3 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Spt20 PF12090.3 CDI77404.1 - 7.3e-05 22.1 6.4 0.053 12.8 0.1 3.1 3 0 0 3 3 3 2 Spt20 family Hira PF07569.6 CDI77404.1 - 0.00063 19.0 0.0 0.0017 17.5 0.0 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split COX14 PF14880.1 CDI77404.1 - 0.0077 15.8 0.6 0.0077 15.8 0.4 2.9 3 0 0 3 3 3 1 Cytochrome oxidase c assembly Abhydro_lipase PF04083.11 CDI77404.1 - 0.6 9.5 1.8 1.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region RAB3GAP2_N PF14655.1 CDI77404.1 - 0.62 9.0 16.7 0.72 8.7 0.3 3.0 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus EphA2_TM PF14575.1 CDI77404.1 - 0.85 10.0 2.7 6.8 7.1 0.1 2.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain FimP PF09766.4 CDI77404.1 - 8.6 5.3 19.6 1.9 7.5 0.3 2.5 3 0 0 3 3 3 0 Fms-interacting protein CAF-1_p150 PF11600.3 CDI77405.1 - 0.003 16.9 43.9 0.0082 15.5 10.8 2.3 2 0 0 2 2 2 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal THRAP3_BCLAF1 PF15440.1 CDI77405.1 - 0.021 13.5 44.9 0.031 12.9 31.1 1.3 1 0 0 1 1 1 0 THRAP3/BCLAF1 family IL4 PF00727.13 CDI77405.1 - 0.15 11.9 0.1 0.15 11.9 0.1 2.4 2 1 1 3 3 3 0 Interleukin 4 AAA_23 PF13476.1 CDI77405.1 - 0.68 10.2 18.3 0.22 11.8 1.0 2.2 2 0 0 2 2 2 0 AAA domain DUF342 PF03961.8 CDI77405.1 - 7.2 4.8 15.2 1.2 7.4 5.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Sad1_UNC PF07738.8 CDI77407.1 - 5e-21 74.9 0.0 1.4e-11 44.2 0.0 2.6 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal SR-25 PF10500.4 CDI77407.1 - 0.017 14.6 1.5 0.017 14.6 1.0 4.5 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein Tweety PF04906.8 CDI77407.1 - 0.017 13.5 1.6 0.049 12.0 0.0 1.9 1 1 1 2 2 2 0 Tweety DUF1091 PF06477.8 CDI77407.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) DUF429 PF04250.8 CDI77407.1 - 0.21 10.7 13.1 0.11 11.7 7.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF429) APG6 PF04111.7 CDI77407.1 - 0.33 9.9 21.0 0.79 8.7 14.5 1.6 1 0 0 1 1 1 0 Autophagy protein Apg6 7tm_7 PF08395.7 CDI77407.1 - 1.1 8.1 4.5 2.2 7.2 3.1 1.4 1 0 0 1 1 1 0 7tm Chemosensory receptor LRR_6 PF13516.1 CDI77408.1 - 0.00055 19.7 0.2 0.072 13.1 0.0 3.7 4 0 0 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.28 CDI77408.1 - 0.0021 17.8 1.0 1 9.6 0.0 3.8 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_4 PF12799.2 CDI77408.1 - 0.0037 16.8 0.5 0.027 14.0 0.0 2.2 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) tRNA-synt_2 PF00152.15 CDI77412.1 - 4.7e-26 91.3 0.1 5.9e-17 61.4 0.0 3.9 4 0 0 4 4 4 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDI77412.1 - 0.0013 18.5 0.0 0.14 12.0 0.0 2.5 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain RIC3 PF15361.1 CDI77412.1 - 0.0098 16.1 0.3 0.0098 16.1 0.2 7.3 8 2 1 9 9 9 1 Resistance to inhibitors of cholinesterase homologue 3 tRNA-synt_2d PF01409.15 CDI77412.1 - 0.025 13.7 0.0 0.091 11.9 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) HATPase_c_5 PF14501.1 CDI77412.1 - 0.075 12.7 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 GHKL domain Clathrin_lg_ch PF01086.12 CDI77413.1 - 6.1e-05 23.0 44.9 0.0029 17.5 31.1 2.4 1 1 0 1 1 1 1 Clathrin light chain MCM PF00493.18 CDI77414.1 - 1.3e-111 372.5 0.1 1.8e-111 372.1 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 CDI77414.1 - 1.2e-05 24.5 0.0 3.9e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDI77414.1 - 0.002 17.8 0.0 0.011 15.5 0.0 2.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 CDI77414.1 - 0.024 14.2 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SR-25 PF10500.4 CDI77414.1 - 2.2 7.7 4.4 24 4.3 0.0 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MCM_N PF14551.1 CDI77415.1 - 2.9e-06 27.7 0.0 3.8e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 MCM N-terminal domain Pkinase PF00069.20 CDI77416.1 - 1.5e-16 60.3 0.0 5.9e-16 58.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI77416.1 - 1.5e-12 47.0 0.0 0.00037 19.5 0.0 3.2 2 1 1 3 3 3 3 Kinase-like Pkinase_Tyr PF07714.12 CDI77416.1 - 0.00016 20.8 0.0 0.0083 15.2 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pex14_N PF04695.8 CDI77416.1 - 0.66 10.0 12.0 1.2 9.2 1.6 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Bap31 PF05529.7 CDI77416.1 - 7.7 5.9 8.6 0.67 9.3 2.2 2.1 2 1 0 2 2 2 0 B-cell receptor-associated protein 31-like 2HCT PF03390.10 CDI77417.1 - 1.2 7.4 4.2 0.25 9.6 0.4 1.7 2 0 0 2 2 2 0 2-hydroxycarboxylate transporter family MOZ_SAS PF01853.13 CDI77418.1 - 5.9e-45 152.8 0.0 5.7e-26 90.9 0.0 2.2 2 0 0 2 2 2 2 MOZ/SAS family Tudor-knot PF11717.3 CDI77418.1 - 1.2e-08 34.4 0.2 5.2e-07 29.2 0.0 2.6 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Pkinase PF00069.20 CDI77419.1 - 6.6e-21 74.6 0.0 3.4e-20 72.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI77419.1 - 1.5e-12 47.0 0.0 4.6e-12 45.4 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI77419.1 - 7.8e-09 34.9 0.0 1.5e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4259 PF14078.1 CDI77419.1 - 0.058 13.8 2.8 0.22 12.0 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4259) GYF PF02213.11 CDI77420.1 - 6.8e-11 41.5 0.0 6.8e-11 41.5 0.0 1.9 2 0 0 2 2 2 1 GYF domain Ribosomal_60s PF00428.14 CDI77422.1 - 0.75 10.2 9.6 0.28 11.6 4.2 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein MMR_HSR1 PF01926.18 CDI77425.1 - 3.5e-16 59.1 0.0 3.3e-13 49.6 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 CDI77425.1 - 1.9e-08 33.7 0.0 9.7e-06 24.9 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.18 CDI77425.1 - 0.0012 18.6 4.8 0.94 9.2 0.1 3.6 3 1 0 4 4 4 2 Dynamin family GTP_EFTU PF00009.22 CDI77425.1 - 0.0022 17.4 0.0 0.21 11.0 0.0 2.9 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 CDI77425.1 - 0.0022 17.2 0.2 0.0057 15.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ArgK PF03308.11 CDI77425.1 - 0.041 12.6 0.4 0.089 11.5 0.3 1.5 1 0 0 1 1 1 0 ArgK protein MobB PF03205.9 CDI77425.1 - 0.062 13.0 0.1 0.19 11.4 0.1 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CDI77425.1 - 1.2 9.0 16.1 0.29 11.0 0.5 3.9 4 1 0 4 4 4 0 AAA ATPase domain Trypsin_2 PF13365.1 CDI77426.1 - 2.9e-13 49.8 0.6 6.1e-13 48.8 0.4 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 CDI77426.1 - 3.3e-12 46.4 0.2 6.7e-12 45.4 0.1 1.4 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 CDI77426.1 - 6e-06 26.0 0.1 7.5e-05 22.5 0.0 2.5 2 0 0 2 2 2 1 PDZ domain LMBR1 PF04791.11 CDI77427.1 - 0.8 8.2 0.5 1.7 7.1 0.4 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein SAPS PF04499.10 CDI77427.1 - 3.1 6.3 11.9 0.29 9.7 5.0 1.6 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF2870 PF11069.3 CDI77429.1 - 1.1e-22 79.8 0.4 2.7e-22 78.6 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) RNA_pol_Rpb4 PF03874.11 CDI77431.1 - 2.7e-07 30.6 0.1 1.1e-06 28.6 0.0 1.8 1 1 1 2 2 2 1 RNA polymerase Rpb4 CBF PF03914.12 CDI77433.1 - 4.9e-19 68.3 0.0 4.9e-19 68.3 0.0 3.3 2 2 0 2 2 2 1 CBF/Mak21 family PBP1_TM PF14812.1 CDI77433.1 - 0.003 17.8 2.4 0.04 14.2 0.4 2.8 3 0 0 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal FLO_LFY PF01698.11 CDI77433.1 - 0.049 12.4 2.7 0.084 11.7 1.8 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein SR-25 PF10500.4 CDI77433.1 - 0.29 10.5 20.1 0.52 9.7 6.0 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Sporozoite_P67 PF05642.6 CDI77433.1 - 2.5 5.8 9.9 0.8 7.4 3.5 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen OMP_b-brl PF13505.1 CDI77433.1 - 2.6 7.9 5.0 1.8 8.4 0.6 2.4 2 0 0 2 2 2 0 Outer membrane protein beta-barrel domain Secretin_N_2 PF07655.8 CDI77433.1 - 5.6 7.4 10.8 26 5.2 0.1 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Glycos_transf_2 PF00535.21 CDI77434.1 - 8.8e-19 67.7 0.1 2.4e-18 66.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 CDI77434.1 - 1.1e-09 37.8 0.0 1.7e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Ricin_B_lectin PF00652.17 CDI77434.1 - 1e-06 28.7 0.3 3.3e-06 27.1 0.2 1.9 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.9 CDI77434.1 - 3.5e-06 26.3 0.1 7.6e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase SR-25 PF10500.4 CDI77434.1 - 0.0043 16.5 10.4 0.007 15.8 7.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4614 PF15391.1 CDI77434.1 - 0.059 13.1 2.8 0.1 12.3 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Secretin_N_2 PF07655.8 CDI77434.1 - 0.94 9.9 12.6 0.28 11.5 6.5 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain Period_C PF12114.3 CDI77434.1 - 6.8 6.2 11.2 13 5.2 7.8 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Macoilin PF09726.4 CDI77434.1 - 8.1 4.5 9.9 13 3.9 6.9 1.2 1 0 0 1 1 1 0 Transmembrane protein Ribosomal_60s PF00428.14 CDI77434.1 - 9.7 6.6 31.6 0.31 11.4 7.0 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein eIF2A PF08662.6 CDI77435.1 - 4.5e-33 114.6 0.0 1.4e-29 103.1 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 CDI77435.1 - 0.082 12.8 0.7 5.3 7.0 0.0 3.7 5 0 0 5 5 5 0 WD domain, G-beta repeat Nudc_N PF14050.1 CDI77436.1 - 1.2e-18 66.7 0.0 2.8e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.11 CDI77436.1 - 0.00016 22.1 1.9 0.075 13.5 0.0 2.6 2 1 1 3 3 3 2 CS domain RAP1 PF07218.6 CDI77436.1 - 3.4 5.6 7.7 4.7 5.1 5.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Dehydrin PF00257.14 CDI77436.1 - 4 7.7 18.0 0.78 10.0 1.2 3.3 3 0 0 3 3 3 0 Dehydrin WBP-1 PF11669.3 CDI77436.1 - 8.7 6.4 12.2 0.7 10.0 1.5 2.8 2 0 0 2 2 2 0 WW domain-binding protein 1 Kelch_3 PF13415.1 CDI77437.1 - 7.5e-41 137.4 2.5 4.8e-07 29.7 0.0 6.7 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.1 CDI77437.1 - 1.6e-39 133.4 4.3 2.9e-08 33.3 0.0 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 CDI77437.1 - 3.2e-26 90.3 0.4 0.00023 21.2 0.4 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 CDI77437.1 - 5.2e-25 86.9 0.3 2.1e-06 27.5 0.0 6.8 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 CDI77437.1 - 3.5e-17 61.6 1.6 0.0042 16.5 0.1 6.8 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 CDI77437.1 - 9.5e-13 47.3 5.0 0.12 12.1 0.0 6.8 6 2 0 6 6 6 3 Kelch motif BLOC1_2 PF10046.4 CDI77437.1 - 0.00068 19.7 13.1 0.0012 18.8 8.8 1.6 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 MCPsignal PF00015.16 CDI77437.1 - 0.0025 17.3 14.3 0.0056 16.2 9.9 1.5 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Reo_sigmaC PF04582.7 CDI77437.1 - 0.0038 16.4 8.7 0.0065 15.6 6.0 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein APG6 PF04111.7 CDI77437.1 - 0.0041 16.1 10.2 0.0063 15.6 7.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 ADIP PF11559.3 CDI77437.1 - 0.011 15.5 9.7 0.011 15.5 6.7 1.9 2 1 0 2 2 1 0 Afadin- and alpha -actinin-Binding Laminin_I PF06008.9 CDI77437.1 - 0.012 14.9 14.2 0.02 14.2 9.8 1.2 1 0 0 1 1 1 0 Laminin Domain I GAS PF13851.1 CDI77437.1 - 0.014 14.5 11.6 0.022 13.9 8.0 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DASH_Duo1 PF08651.5 CDI77437.1 - 0.019 14.5 6.4 0.072 12.6 0.9 2.5 1 1 1 2 2 2 0 DASH complex subunit Duo1 Laminin_II PF06009.7 CDI77437.1 - 0.021 14.5 16.2 0.038 13.7 5.3 2.3 1 1 1 2 2 2 0 Laminin Domain II AAA_13 PF13166.1 CDI77437.1 - 0.028 12.9 11.1 0.045 12.2 7.7 1.2 1 0 0 1 1 1 0 AAA domain CCDC144C PF14915.1 CDI77437.1 - 0.033 13.1 12.5 0.056 12.3 8.7 1.3 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF489 PF04356.7 CDI77437.1 - 0.035 13.7 5.2 0.058 12.9 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) Fib_alpha PF08702.5 CDI77437.1 - 0.062 13.4 8.9 0.14 12.3 6.2 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Atg14 PF10186.4 CDI77437.1 - 0.069 12.0 11.9 0.11 11.4 7.8 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cluap1 PF10234.4 CDI77437.1 - 0.072 12.2 7.2 0.14 11.3 5.0 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 Tropomyosin PF00261.15 CDI77437.1 - 0.086 11.9 13.1 0.15 11.0 9.1 1.3 1 0 0 1 1 1 0 Tropomyosin Spc7 PF08317.6 CDI77437.1 - 0.11 11.1 14.8 0.16 10.5 10.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TMPIT PF07851.8 CDI77437.1 - 0.12 11.4 8.3 0.18 10.8 5.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein TMCO5 PF14992.1 CDI77437.1 - 0.12 11.4 8.7 0.26 10.3 6.0 1.5 1 0 0 1 1 1 0 TMCO5 family Vps53_N PF04100.7 CDI77437.1 - 0.15 10.7 10.4 0.24 10.1 7.2 1.3 1 0 0 1 1 1 0 Vps53-like, N-terminal DUF342 PF03961.8 CDI77437.1 - 0.22 9.9 6.5 0.32 9.3 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Tropomyosin_1 PF12718.2 CDI77437.1 - 0.3 10.9 13.6 0.56 10.0 9.4 1.4 1 0 0 1 1 1 0 Tropomyosin like Syntaxin-6_N PF09177.6 CDI77437.1 - 0.57 10.6 9.5 8.3 6.8 0.9 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal IncA PF04156.9 CDI77437.1 - 0.58 9.7 13.7 4.7 6.7 9.5 2.2 1 1 0 1 1 1 0 IncA protein Prominin PF05478.6 CDI77437.1 - 0.59 7.5 9.2 0.83 7.1 6.4 1.1 1 0 0 1 1 1 0 Prominin Ran-binding PF05508.6 CDI77437.1 - 0.71 8.7 9.8 1.1 8.1 6.8 1.2 1 0 0 1 1 1 0 RanGTP-binding protein DUF948 PF06103.6 CDI77437.1 - 0.87 9.4 15.3 0.076 12.8 2.4 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Mnd1 PF03962.10 CDI77437.1 - 0.9 9.1 10.2 2.1 7.9 7.1 1.6 1 0 0 1 1 1 0 Mnd1 family DUF2229 PF09989.4 CDI77437.1 - 1 8.7 7.6 0.06 12.7 1.6 1.5 2 0 0 2 2 1 0 CoA enzyme activase uncharacterised domain (DUF2229) V_ATPase_I PF01496.14 CDI77437.1 - 1.1 7.0 6.5 1.5 6.5 4.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.7 CDI77437.1 - 1.5 8.6 11.9 1.8 8.3 6.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.17 CDI77437.1 - 1.7 8.7 14.6 7.8 6.5 4.5 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.7 CDI77437.1 - 4.2 7.6 12.8 1.2e+02 3.0 8.9 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.6 CDI77437.1 - 9.2 6.1 12.3 21 4.9 5.0 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 cNMP_binding PF00027.24 CDI77438.1 - 1.4e-09 37.5 15.5 5.1e-08 32.6 9.7 3.1 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain DUF2154 PF09922.4 CDI77440.1 - 0.065 12.9 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Cell wall-active antibiotics response protein (DUF2154) DUF3846 PF12957.2 CDI77440.1 - 0.088 12.5 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3846) Miro PF08477.8 CDI77442.1 - 0.022 15.2 0.0 0.061 13.8 0.0 1.8 1 1 1 2 2 2 0 Miro-like protein AAA_22 PF13401.1 CDI77442.1 - 0.031 14.4 3.7 0.079 13.1 0.2 2.9 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.1 CDI77442.1 - 0.034 14.1 0.1 0.034 14.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.5 CDI77442.1 - 0.063 12.4 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dehydrin PF00257.14 CDI77442.1 - 0.21 11.9 2.7 0.47 10.7 0.8 2.3 2 1 0 2 2 2 0 Dehydrin ERM PF00769.14 CDI77442.1 - 1.9 7.9 12.1 3.8 6.9 8.4 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Macoilin PF09726.4 CDI77442.1 - 3.9 5.6 11.3 8.2 4.5 7.8 1.5 1 0 0 1 1 1 0 Transmembrane protein Metallophos PF00149.23 CDI77443.1 - 0.0013 18.1 1.0 0.052 12.9 0.3 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDI77443.1 - 0.0039 17.0 0.0 2.7 7.8 0.0 2.9 3 0 0 3 3 3 2 Calcineurin-like phosphoesterase superfamily domain PUB PF09409.5 CDI77444.1 - 3.6e-11 42.6 0.0 1.7e-09 37.3 0.0 2.5 1 1 0 1 1 1 1 PUB domain Big_3_3 PF13750.1 CDI77444.1 - 0.067 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) NIL PF09383.5 CDI77444.1 - 0.28 10.7 0.0 0.28 10.7 0.0 2.4 3 1 0 3 3 3 0 NIL domain FAM178 PF14816.1 CDI77444.1 - 0.6 8.7 9.7 0.052 12.2 3.2 1.7 1 1 1 2 2 2 0 Family of unknown function, FAM178 Selenoprotein_S PF06936.6 CDI77444.1 - 9.2 5.7 16.7 20 4.6 11.6 1.6 1 0 0 1 1 1 0 Selenoprotein S (SelS) APG6 PF04111.7 CDI77447.1 - 7.1e-47 159.9 0.0 8.8e-27 93.9 0.0 2.8 1 1 1 2 2 2 2 Autophagy protein Apg6 GAS PF13851.1 CDI77447.1 - 0.24 10.5 3.9 0.36 9.9 2.7 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Ctr PF04145.10 CDI77448.1 - 2.1e-14 53.7 0.0 2.3e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Ribosomal_S15 PF00312.17 CDI77450.1 - 1.7e-16 59.7 1.7 2.9e-16 59.0 1.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 Ank_2 PF12796.2 CDI77451.1 - 3.6e-45 152.2 7.1 9.8e-18 64.2 0.5 4.5 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 CDI77451.1 - 1.8e-41 137.8 12.6 5e-06 26.0 0.0 8.2 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.1 CDI77451.1 - 1.1e-37 127.1 15.2 1.5e-13 50.5 0.9 6.7 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDI77451.1 - 2.6e-30 104.2 3.8 5.1e-10 39.5 0.2 7.3 5 3 4 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI77451.1 - 1.3e-27 93.0 6.7 0.00043 20.2 0.0 8.5 8 0 0 8 8 8 6 Ankyrin repeat TPR_11 PF13414.1 CDI77451.1 - 1.8e-10 40.3 5.4 1.7e-09 37.1 0.7 3.2 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 CDI77451.1 - 0.0021 17.8 5.9 0.49 10.4 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat UQ_con PF00179.21 CDI77452.1 - 3.6e-52 175.5 0.0 4.4e-52 175.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDI77452.1 - 8.9e-05 22.2 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDI77452.1 - 0.0052 16.6 0.1 0.0071 16.2 0.1 1.4 1 1 0 1 1 1 1 RWD domain Herpes_VP19C PF03327.9 CDI77453.1 - 0.16 10.8 0.4 0.4 9.5 0.1 1.8 2 0 0 2 2 2 0 Herpesvirus capsid shell protein VP19C Pex14_N PF04695.8 CDI77453.1 - 0.19 11.7 12.5 0.15 12.1 2.6 3.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RR_TM4-6 PF06459.7 CDI77453.1 - 0.69 9.7 4.8 0.93 9.3 0.9 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FHIPEP PF00771.15 CDI77453.1 - 1.4 7.1 4.9 4.1 5.5 0.1 2.3 2 0 0 2 2 2 0 FHIPEP family Ycf1 PF05758.7 CDI77453.1 - 1.8 6.1 1.2 2.6 5.6 0.9 1.2 1 0 0 1 1 1 0 Ycf1 Neur_chan_memb PF02932.11 CDI77453.1 - 1.9 8.3 3.1 7.3 6.3 2.2 2.0 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Fusion_gly PF00523.13 CDI77453.1 - 2.2 6.2 4.3 3.3 5.6 3.0 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF912 PF06024.7 CDI77453.1 - 3.7 7.6 3.4 5.4 7.1 1.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Peptidase_S49_N PF08496.5 CDI77453.1 - 8.5 6.1 7.2 37 4.0 3.2 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Tub PF01167.13 CDI77454.1 - 1.3e-06 27.6 0.8 4e-05 22.7 0.0 2.7 1 1 1 2 2 2 1 Tub family Nitroreductase PF00881.19 CDI77454.1 - 0.076 12.8 4.1 0.17 11.6 0.9 2.2 2 0 0 2 2 2 0 Nitroreductase family ATG11 PF10377.4 CDI77454.1 - 2.9 7.7 6.1 0.49 10.2 0.8 2.0 2 0 0 2 2 2 0 Autophagy-related protein 11 CDK2AP PF09806.4 CDI77454.1 - 7 6.8 24.3 1.2 9.2 3.3 3.1 3 0 0 3 3 3 0 Cyclin-dependent kinase 2-associated protein Pex14_N PF04695.8 CDI77455.1 - 0.0041 17.1 24.9 0.16 12.0 10.9 2.2 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Amnionless PF14828.1 CDI77455.1 - 0.0053 15.3 7.1 0.0069 14.9 4.9 1.1 1 0 0 1 1 1 1 Amnionless Potyvirid-P3 PF13608.1 CDI77455.1 - 0.0073 15.4 6.0 0.0096 15.0 4.2 1.1 1 0 0 1 1 1 1 Protein P3 of Potyviral polyprotein SAPS PF04499.10 CDI77455.1 - 0.0079 14.8 0.9 0.0079 14.8 0.6 2.0 1 1 1 2 2 2 1 SIT4 phosphatase-associated protein Presenilin PF01080.12 CDI77455.1 - 0.0097 14.7 10.9 0.014 14.2 7.6 1.2 1 0 0 1 1 1 1 Presenilin RAP1 PF07218.6 CDI77455.1 - 0.047 11.7 5.1 0.055 11.5 3.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SID-1_RNA_chan PF13965.1 CDI77455.1 - 0.11 10.6 2.3 0.14 10.2 1.6 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PBP1_TM PF14812.1 CDI77455.1 - 0.19 12.0 5.5 0.22 11.8 0.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Apt1 PF10351.4 CDI77455.1 - 0.22 10.3 8.1 0.3 9.9 5.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Nucleos_tra2_C PF07662.8 CDI77455.1 - 0.33 10.4 5.4 0.09 12.2 0.3 2.1 1 1 0 2 2 2 0 Na+ dependent nucleoside transporter C-terminus DUF4135 PF13575.1 CDI77455.1 - 0.96 8.3 7.8 1.2 8.0 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) FAM176 PF14851.1 CDI77455.1 - 0.97 9.1 10.7 3.6 7.2 2.4 2.2 2 0 0 2 2 2 0 FAM176 family Pap_E4 PF02711.9 CDI77455.1 - 1.2 9.9 12.1 6.9 7.5 3.3 2.3 2 0 0 2 2 2 0 E4 protein Sod_Fe_N PF00081.17 CDI77455.1 - 1.3 9.3 10.4 0.13 12.5 3.3 2.1 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, alpha-hairpin domain DDRGK PF09756.4 CDI77455.1 - 1.5 8.1 21.4 1.9 7.8 1.1 2.1 2 0 0 2 2 2 0 DDRGK domain Hom_end_hint PF05203.11 CDI77455.1 - 1.6 8.4 9.3 2.2 7.9 0.7 2.1 2 0 0 2 2 2 0 Hom_end-associated Hint RED_N PF07808.8 CDI77455.1 - 2.7 7.1 23.0 0.48 9.5 7.1 2.2 2 0 0 2 2 2 0 RED-like protein N-terminal region SAGA-Tad1 PF12767.2 CDI77455.1 - 3.4 7.2 20.4 0.69 9.5 4.8 2.1 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF1180 PF06679.7 CDI77455.1 - 5.5 6.8 12.3 9.6 6.0 8.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) LIM_bind PF01803.11 CDI77455.1 - 6.7 5.7 15.9 2.2 7.3 2.1 2.1 2 0 0 2 2 2 0 LIM-domain binding protein Mtc PF03820.12 CDI77458.1 - 0.029 13.0 0.3 0.21 10.2 0.0 2.3 2 0 0 2 2 2 0 Tricarboxylate carrier Abhydrolase_5 PF12695.2 CDI77459.1 - 9.2e-21 74.1 0.0 9.2e-21 74.1 0.0 3.8 3 2 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CDI77459.1 - 0.0021 17.5 0.2 0.048 13.1 0.0 2.4 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 CDI77459.1 - 0.021 14.4 0.0 1.7 8.1 0.0 2.5 1 1 1 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CDI77459.1 - 0.03 13.5 0.0 0.093 11.9 0.0 1.9 1 0 0 1 1 1 0 Prolyl oligopeptidase family PAT1 PF09770.4 CDI77460.1 - 1 7.5 13.8 1.2 7.3 9.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PNRC PF15365.1 CDI77460.1 - 1.2 9.2 7.7 0.43 10.6 1.3 2.5 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator DUF4613 PF15390.1 CDI77460.1 - 2.7 6.0 5.4 3.4 5.7 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) TFIIA PF03153.8 CDI77460.1 - 6.7 6.5 11.2 9.2 6.0 7.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ADK PF00406.17 CDI77461.1 - 2.6e-32 111.7 0.0 3.1e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 CDI77461.1 - 7.2e-17 60.7 0.3 2e-16 59.3 0.1 1.9 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.1 CDI77461.1 - 0.0048 16.7 0.0 0.011 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain PAP2 PF01569.16 CDI77462.1 - 0.052 13.2 0.6 0.37 10.4 0.0 2.2 2 0 0 2 2 2 0 PAP2 superfamily PAP2 PF01569.16 CDI77463.1 - 5.3e-19 68.1 1.5 5.3e-19 68.1 1.0 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.1 CDI77463.1 - 0.14 12.4 9.5 0.32 11.2 0.2 3.6 4 0 0 4 4 4 0 PAP2 superfamily C-terminal PDZ PF00595.19 CDI77465.1 - 0.0001 22.3 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 CDI77465.1 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain NYD-SP28_assoc PF14775.1 CDI77466.1 - 0.079 12.6 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain DUF948 PF06103.6 CDI77466.1 - 0.18 11.6 1.3 1.1 9.1 0.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) CPSF100_C PF13299.1 CDI77467.1 - 5.8 7.0 7.7 0.69 10.0 0.6 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Transformer PF06495.6 CDI77473.1 - 0.15 11.9 9.8 0.22 11.3 6.8 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein HAD PF12710.2 CDI77474.1 - 2.9e-05 24.3 0.2 0.0041 17.3 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase BAF1_ABF1 PF04684.8 CDI77474.1 - 0.00092 18.1 21.2 0.00092 18.1 14.7 4.7 3 1 2 5 5 3 1 BAF1 / ABF1 chromatin reorganising factor Pribosyltran PF00156.22 CDI77474.1 - 0.0046 16.6 0.1 0.014 15.1 0.1 1.9 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Hydrolase_3 PF08282.7 CDI77474.1 - 0.012 15.2 7.7 0.15 11.5 4.9 2.7 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4011 PF13195.1 CDI77474.1 - 0.15 12.0 6.0 0.45 10.5 4.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) SAPS PF04499.10 CDI77474.1 - 0.6 8.6 11.7 3.5 6.1 3.9 3.0 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein PAT1 PF09770.4 CDI77474.1 - 1 7.5 28.7 1.9 6.6 19.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DDRGK PF09756.4 CDI77474.1 - 1.2 8.4 15.9 2.1 7.7 11.0 1.3 1 0 0 1 1 1 0 DDRGK domain Tim54 PF11711.3 CDI77474.1 - 1.3 7.5 7.6 2.7 6.4 5.2 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ycf1 PF05758.7 CDI77474.1 - 2.7 5.6 8.9 3.9 5.0 6.2 1.1 1 0 0 1 1 1 0 Ycf1 Hydrolase PF00702.21 CDI77474.1 - 4.4 7.6 20.9 5.1 7.4 6.5 4.0 3 2 0 3 3 3 0 haloacid dehalogenase-like hydrolase PBP1_TM PF14812.1 CDI77474.1 - 5 7.5 6.6 18 5.7 4.4 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Med15 PF09606.5 CDI77477.1 - 0.53 8.4 35.2 0.88 7.6 24.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RAP1 PF07218.6 CDI77477.1 - 3.9 5.4 13.2 7.6 4.4 9.1 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ArfGap PF01412.13 CDI77478.1 - 2.7e-12 46.4 4.2 8.1e-09 35.2 0.0 3.5 2 1 1 3 3 3 2 Putative GTPase activating protein for Arf DUF3043 PF11241.3 CDI77478.1 - 0.29 10.7 1.7 0.78 9.3 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) RCR PF12273.3 CDI77478.1 - 0.74 10.3 15.6 0.096 13.2 7.6 1.9 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red TraT PF05818.7 CDI77478.1 - 0.8 9.0 15.4 0.11 11.9 7.7 1.6 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein Med15 PF09606.5 CDI77478.1 - 0.91 7.6 36.8 1.4 7.0 25.5 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF-3_zeta PF05091.7 CDI77478.1 - 1.3 7.5 11.5 1.7 7.1 7.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Draxin PF15550.1 CDI77478.1 - 2.7 7.5 11.6 4 6.9 8.0 1.3 1 0 0 1 1 1 0 Draxin TFIIA PF03153.8 CDI77478.1 - 3.8 7.3 29.0 5.2 6.8 20.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dehydrin PF00257.14 CDI77478.1 - 6.9 6.9 18.5 1.7e+02 2.4 12.8 2.4 1 1 0 1 1 1 0 Dehydrin FimP PF09766.4 CDI77478.1 - 7.1 5.5 15.8 0.31 10.0 5.6 2.1 2 0 0 2 2 2 0 Fms-interacting protein Macoilin PF09726.4 CDI77478.1 - 7.2 4.7 16.3 9.9 4.2 11.3 1.1 1 0 0 1 1 1 0 Transmembrane protein E1-E2_ATPase PF00122.15 CDI77479.1 - 5.3e-30 104.1 5.1 1.2e-29 103.0 0.1 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 CDI77479.1 - 5.7e-23 82.4 0.0 1.1e-17 65.2 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDI77479.1 - 1.8e-10 41.2 0.8 7.8e-09 35.9 0.4 3.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 CDI77479.1 - 3.8e-09 36.5 0.0 8.6e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.7 CDI77479.1 - 0.019 14.5 0.0 2.8 7.4 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Zea_mays_MuDR PF05928.6 CDI77479.1 - 1.5 8.1 3.3 2.1 7.7 1.4 1.8 2 0 0 2 2 2 0 Zea mays MURB-like protein (MuDR) Virul_fac_BrkB PF03631.10 CDI77480.1 - 0.0014 18.0 1.7 0.0014 18.0 1.2 3.2 4 0 0 4 4 4 1 Virulence factor BrkB Orthopox_B11R PF07033.6 CDI77480.1 - 0.17 11.3 0.2 0.4 10.1 0.1 1.6 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Wzy_C PF04932.10 CDI77480.1 - 0.41 10.4 7.6 0.094 12.4 1.0 2.6 3 0 0 3 3 3 0 O-Antigen ligase DEAD PF00270.24 CDI77481.1 - 4.8e-23 81.4 0.0 7.9e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI77481.1 - 1.3e-13 50.6 0.7 2.3e-13 49.8 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDI77481.1 - 0.015 15.4 0.0 0.1 12.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CDI77481.1 - 0.13 11.9 0.9 0.68 9.7 0.6 2.3 1 1 0 1 1 1 0 Part of AAA domain Abhydrolase_6 PF12697.2 CDI77482.1 - 3.2e-20 72.9 0.2 5.5e-20 72.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDI77482.1 - 7.3e-09 35.5 0.0 1.6e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI77482.1 - 4.2e-06 26.4 0.0 0.00024 20.7 0.0 2.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.8 CDI77482.1 - 0.00016 21.3 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 CDI77482.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.3 CDI77482.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase Thioesterase PF00975.15 CDI77482.1 - 0.1 12.7 0.0 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain Dynein_heavy PF03028.10 CDI77483.1 - 8.1e-127 424.1 0.1 6.3e-55 186.4 0.0 3.2 1 1 1 3 3 3 3 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 CDI77483.1 - 1e-59 201.1 1.3 1.7e-59 200.4 0.9 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 DUF3548 PF12068.3 CDI77483.1 - 0.13 11.5 0.3 0.32 10.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3548) AAA_8 PF12780.2 CDI77484.1 - 2.4e-74 249.7 0.1 4e-65 219.4 0.0 2.3 1 1 1 2 2 2 2 P-loop containing dynein motor region D4 MT PF12777.2 CDI77484.1 - 1e-73 248.1 13.7 1.3e-73 247.7 9.5 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 CDI77484.1 - 2e-38 132.0 1.5 5.2e-36 124.1 0.1 2.6 2 1 1 3 3 3 2 P-loop containing dynein motor region D3 AAA_5 PF07728.9 CDI77484.1 - 2.3e-07 30.6 0.0 8.2e-05 22.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Reo_sigmaC PF04582.7 CDI77484.1 - 0.051 12.7 8.0 4.2 6.4 2.9 2.8 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Prominin PF05478.6 CDI77484.1 - 0.07 10.6 7.3 0.054 11.0 1.0 2.1 2 0 0 2 2 2 0 Prominin Spc7 PF08317.6 CDI77484.1 - 0.092 11.3 16.5 0.96 8.0 6.4 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein cwf21 PF08312.7 CDI77484.1 - 0.43 10.4 5.0 7.9 6.4 0.1 3.2 2 1 0 2 2 2 0 cwf21 domain IncA PF04156.9 CDI77484.1 - 0.77 9.3 19.6 0.03 13.9 1.7 2.3 2 0 0 2 2 2 0 IncA protein Laminin_II PF06009.7 CDI77484.1 - 2.5 7.8 19.0 0.031 14.0 1.2 3.3 2 1 1 3 3 3 0 Laminin Domain II V_ATPase_I PF01496.14 CDI77484.1 - 4.5 5.0 12.3 4.4 5.0 0.2 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family FUSC PF04632.7 CDI77484.1 - 5.9 5.1 6.7 9.8 4.4 0.2 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF4164 PF13747.1 CDI77484.1 - 8.2 6.6 20.3 12 6.0 4.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) AAA_6 PF12774.2 CDI77485.1 - 1.1e-105 352.3 1.7 8.5e-67 225.0 0.1 2.2 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 CDI77485.1 - 3.3e-10 39.8 0.0 6.2e-07 29.2 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CDI77485.1 - 5.6e-07 30.4 0.1 0.068 13.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 CDI77485.1 - 6.3e-06 26.5 0.0 0.092 13.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 CDI77485.1 - 8.5e-05 22.7 0.4 0.061 13.5 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDI77485.1 - 0.00029 20.7 0.1 0.85 9.4 0.0 3.0 3 1 0 3 3 3 2 AAA domain AAA_19 PF13245.1 CDI77485.1 - 0.00082 19.0 0.6 0.16 11.7 0.1 3.3 3 0 0 3 3 3 1 Part of AAA domain AAA_22 PF13401.1 CDI77485.1 - 0.002 18.2 0.0 3.9 7.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 CDI77485.1 - 0.005 16.4 0.2 1.2 8.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CDI77485.1 - 0.0057 16.8 0.0 1.3 9.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Zeta_toxin PF06414.7 CDI77485.1 - 0.0073 15.4 0.1 1.1 8.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 CDI77485.1 - 0.0089 16.0 0.6 3.4 7.6 0.0 3.1 4 1 1 5 5 4 1 AAA ATPase domain ATP_bind_1 PF03029.12 CDI77485.1 - 0.04 13.4 1.3 1.2 8.6 0.0 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 CDI77485.1 - 0.04 13.3 0.0 0.086 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA-like domain KTI12 PF08433.5 CDI77485.1 - 0.046 12.9 0.0 0.2 10.8 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ArgK PF03308.11 CDI77485.1 - 0.05 12.3 0.0 0.11 11.2 0.0 1.5 1 0 0 1 1 1 0 ArgK protein AAA_14 PF13173.1 CDI77485.1 - 0.13 12.1 0.0 34 4.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain Baculo_helicase PF04735.7 CDI77485.1 - 0.26 8.6 0.0 0.38 8.0 0.0 1.1 1 0 0 1 1 1 0 Baculovirus DNA helicase DHC_N2 PF08393.8 CDI77486.1 - 3.4e-10 39.0 6.9 3.3e-09 35.7 0.4 2.7 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 2 TIG PF01833.19 CDI77486.1 - 2.7e-06 27.2 0.7 5e-06 26.4 0.5 1.5 1 0 0 1 1 1 1 IPT/TIG domain Filamin PF00630.14 CDI77486.1 - 0.00037 21.0 0.0 0.00083 19.8 0.0 1.6 1 1 0 1 1 1 1 Filamin/ABP280 repeat FANCI_S3 PF14677.1 CDI77486.1 - 0.007 15.7 0.7 0.015 14.7 0.1 1.8 2 0 0 2 2 2 1 FANCI solenoid 3 NPV_P10 PF05531.7 CDI77486.1 - 0.017 15.3 8.6 8.3 6.7 0.5 4.5 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein Neuropep_like PF15161.1 CDI77486.1 - 0.061 12.8 0.1 0.47 9.9 0.0 2.4 2 0 0 2 2 2 0 Neuropeptide-like Med21 PF11221.3 CDI77490.1 - 1.3e-05 25.1 0.7 2.8e-05 24.1 0.5 1.5 1 1 0 1 1 1 1 Subunit 21 of Mediator complex UPF0184 PF03670.8 CDI77490.1 - 0.026 14.6 0.2 0.035 14.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Sin3_corepress PF08295.7 CDI77490.1 - 0.099 12.4 0.2 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 Sin3 family co-repressor DUF3606 PF12244.3 CDI77490.1 - 0.26 10.9 3.2 0.36 10.5 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) DUF1470 PF07336.6 CDI77490.1 - 0.4 11.0 3.9 0.28 11.5 1.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1470) MMR_HSR1 PF01926.18 CDI77491.1 - 3.1e-13 49.6 0.0 7e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDI77491.1 - 0.00045 19.5 0.0 0.00077 18.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.11 CDI77491.1 - 0.0021 17.1 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 AIG1 family AAA_18 PF13238.1 CDI77491.1 - 0.054 13.8 0.0 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CDI77491.1 - 0.13 11.4 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF3323 PF11796.3 CDI77492.1 - 0.07 12.4 0.2 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) Pkinase PF00069.20 CDI77493.1 - 2.9e-50 170.8 0.0 4.2e-50 170.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77493.1 - 7.9e-42 143.1 0.0 1.1e-41 142.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI77493.1 - 0.017 14.0 0.0 0.036 13.0 0.0 1.5 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 CDI77493.1 - 0.026 13.8 0.0 0.048 13.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Actin PF00022.14 CDI77494.1 - 1.8e-153 510.6 0.0 2e-153 510.4 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 CDI77494.1 - 0.13 12.6 0.0 0.46 10.8 0.0 1.8 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) AP2 PF00847.15 CDI77495.1 - 3.3e-12 46.3 7.3 6.6e-05 22.9 0.3 3.6 3 0 0 3 3 3 3 AP2 domain AP2 PF00847.15 CDI77496.1 - 4.2e-07 30.0 2.6 0.021 14.9 0.6 2.4 2 0 0 2 2 2 2 AP2 domain LRR_6 PF13516.1 CDI77497.1 - 1.2e-07 31.0 0.2 0.45 10.7 0.0 4.6 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 CDI77497.1 - 1.8e-07 30.6 0.3 0.024 14.2 0.0 3.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CDI77497.1 - 0.017 15.0 0.0 1.2e+02 3.3 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 CDI77497.1 - 0.079 13.2 0.3 78 4.1 0.0 4.0 3 0 0 3 3 3 0 Leucine rich repeat ABC_tran PF00005.22 CDI77498.1 - 6.4e-32 110.7 0.1 1.8e-30 106.0 0.1 2.4 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CDI77498.1 - 2.2e-10 40.4 1.8 4.1e-10 39.5 1.3 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 CDI77498.1 - 4e-09 36.0 0.0 5.7e-08 32.2 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 CDI77498.1 - 4.2e-05 23.7 0.0 0.08 13.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CDI77498.1 - 8.7e-05 22.5 9.9 0.00049 20.1 6.8 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 CDI77498.1 - 0.00012 21.5 0.1 0.1 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain G-alpha PF00503.15 CDI77498.1 - 0.00023 19.9 0.0 0.00033 19.4 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_21 PF13304.1 CDI77498.1 - 0.00026 21.0 0.0 0.17 11.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CDI77498.1 - 0.00075 20.3 0.0 0.0018 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDI77498.1 - 0.0017 17.8 0.0 0.0043 16.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.24 CDI77498.1 - 0.0068 16.6 0.2 3.6 7.7 0.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 CDI77498.1 - 0.011 14.7 0.2 0.035 13.1 0.1 1.8 1 1 0 1 1 1 0 Zeta toxin AAA_19 PF13245.1 CDI77498.1 - 0.015 15.0 1.1 0.057 13.1 0.0 2.6 2 0 0 2 2 1 0 Part of AAA domain AAA_14 PF13173.1 CDI77498.1 - 0.017 15.0 0.0 0.17 11.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CDI77498.1 - 0.018 14.2 0.0 0.039 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_33 PF13671.1 CDI77498.1 - 0.026 14.4 3.3 0.13 12.0 2.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CDI77498.1 - 0.027 13.9 0.0 2 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain BAF1_ABF1 PF04684.8 CDI77498.1 - 0.083 11.7 14.4 0.15 10.8 10.0 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AAA_5 PF07728.9 CDI77498.1 - 0.085 12.5 0.0 0.27 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Rad17 PF03215.10 CDI77498.1 - 0.14 10.8 0.0 0.22 10.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Dala_Dala_lig_N PF01820.16 CDI77498.1 - 0.17 12.2 0.9 25 5.1 0.0 2.3 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_23 PF13476.1 CDI77498.1 - 0.26 11.6 6.7 4.3 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 CDI77498.1 - 1.3 9.0 5.9 0.17 11.8 0.3 2.4 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit FimP PF09766.4 CDI77498.1 - 2.2 7.2 11.2 3.5 6.5 7.8 1.2 1 0 0 1 1 1 0 Fms-interacting protein NAM-associated PF14303.1 CDI77499.1 - 0.33 11.2 14.9 0.47 10.7 10.3 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain PAT1 PF09770.4 CDI77499.1 - 0.47 8.6 24.6 0.51 8.5 17.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GNT-I PF03071.10 CDI77499.1 - 0.59 8.6 4.0 0.73 8.3 2.8 1.1 1 0 0 1 1 1 0 GNT-I family RR_TM4-6 PF06459.7 CDI77499.1 - 0.69 9.7 22.3 0.62 9.9 14.8 1.4 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.9 CDI77499.1 - 1.5 8.4 13.9 1.9 8.1 9.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Band_3_cyto PF07565.8 CDI77499.1 - 1.8 7.9 8.8 2.3 7.6 6.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Atg14 PF10186.4 CDI77499.1 - 1.9 7.3 10.8 2.3 7.0 7.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Peptidase_S49_N PF08496.5 CDI77499.1 - 1.9 8.2 11.1 0.49 10.1 4.5 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Lin-8 PF03353.10 CDI77499.1 - 2.1 7.5 14.4 2.9 7.0 10.0 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PLRV_ORF5 PF01690.12 CDI77499.1 - 2.4 7.2 16.4 2.9 6.9 11.4 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Ndc1_Nup PF09531.5 CDI77499.1 - 2.9 6.2 7.2 3.5 5.9 5.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF106 PF01956.11 CDI77499.1 - 4.6 6.7 6.4 7.5 6.0 4.4 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF106 Ycf1 PF05758.7 CDI77499.1 - 7.1 4.2 8.8 7.7 4.0 6.1 1.1 1 0 0 1 1 1 0 Ycf1 HATPase_c PF02518.21 CDI77501.1 - 3.5e-08 33.1 0.1 2.4e-07 30.4 0.1 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_23 PF13476.1 CDI77501.1 - 8.2 6.6 20.6 0.14 12.4 1.0 3.2 3 0 0 3 3 3 0 AAA domain ApbA PF02558.11 CDI77503.1 - 0.0006 19.2 0.0 0.0016 17.9 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA U3_snoRNA_assoc PF08297.6 CDI77503.1 - 0.16 12.2 4.9 0.72 10.1 0.2 2.9 2 0 0 2 2 2 0 U3 snoRNA associated Hydrolase PF00702.21 CDI77504.1 - 2.3e-19 70.6 7.2 3.4e-09 37.4 0.0 4.6 4 0 0 4 4 4 3 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDI77504.1 - 2.4e-14 53.9 0.0 1.1e-13 51.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CDI77504.1 - 2.7e-05 23.3 8.9 0.0027 16.7 0.0 3.8 3 1 1 4 4 4 2 E1-E2 ATPase Med15 PF09606.5 CDI77504.1 - 0.0007 17.9 33.0 0.0007 17.9 22.8 6.9 6 1 0 7 7 7 3 ARC105 or Med15 subunit of Mediator complex non-fungal SprA-related PF12118.3 CDI77504.1 - 0.0036 16.6 18.7 0.0036 16.6 13.0 9.3 9 1 0 9 9 9 1 SprA-related family Hydrolase_3 PF08282.7 CDI77504.1 - 0.12 11.8 0.1 0.12 11.8 0.0 3.2 5 0 0 5 5 5 0 haloacid dehalogenase-like hydrolase EF-hand_7 PF13499.1 CDI77505.1 - 3.3e-39 132.8 12.9 9.7e-11 41.6 0.1 3.9 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.27 CDI77505.1 - 1.7e-28 95.7 10.9 4e-05 22.6 0.2 6.6 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.1 CDI77505.1 - 4e-25 85.4 3.8 0.00044 19.9 0.0 6.3 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.1 CDI77505.1 - 2.2e-24 83.6 9.4 8.9e-05 21.6 0.1 6.7 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 CDI77505.1 - 2.3e-11 43.1 12.7 0.0072 15.9 0.1 6.0 4 2 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 CDI77505.1 - 4.4e-10 39.5 6.3 0.0066 16.4 0.2 3.4 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 CDI77505.1 - 0.009 15.7 7.0 0.58 9.9 0.0 4.1 2 1 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 CDI77505.1 - 0.019 15.2 4.5 4.8 7.5 0.3 3.4 1 1 3 4 4 4 0 Toprim-like Toprim PF01751.17 CDI77505.1 - 0.064 13.2 1.7 12 5.9 0.0 2.9 1 1 1 2 2 2 0 Toprim domain Unstab_antitox PF09720.5 CDI77505.1 - 0.091 12.4 3.3 0.72 9.5 0.0 3.4 3 1 0 3 3 3 0 Putative addiction module component TAFH PF07531.9 CDI77505.1 - 0.11 12.0 1.0 7 6.3 0.1 2.6 3 0 0 3 3 2 0 NHR1 homology to TAF Bac_globin PF01152.16 CDI77505.1 - 0.11 12.4 1.2 14 5.7 0.1 2.4 2 0 0 2 2 2 0 Bacterial-like globin DUF3867 PF12983.2 CDI77505.1 - 1.3 8.9 6.1 9.4 6.1 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3867) Cache_2 PF08269.6 CDI77505.1 - 2.1 8.3 5.9 1.4 8.9 0.3 2.9 3 1 0 3 3 3 0 Cache domain DUF3887 PF13026.1 CDI77505.1 - 4.4 7.6 8.1 0.32 11.3 0.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3887) YtkA PF13115.1 CDI77505.1 - 4.5 7.6 6.7 1.3 9.3 0.4 2.8 1 1 2 3 3 3 0 YtkA-like PAS_4 PF08448.5 CDI77506.1 - 0.076 13.0 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 PAS fold Aldo_ket_red PF00248.16 CDI77507.1 - 1.9e-33 115.4 0.0 1.5e-28 99.4 0.0 2.2 2 0 0 2 2 2 2 Aldo/keto reductase family Ank_2 PF12796.2 CDI77509.1 - 3e-18 65.9 0.3 3.9e-12 46.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI77509.1 - 1.3e-16 60.6 2.4 4.3e-09 36.6 0.3 3.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 CDI77509.1 - 3.6e-16 58.0 0.5 5.5e-09 35.3 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 CDI77509.1 - 1.6e-14 53.5 1.0 7.4e-10 38.7 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI77509.1 - 1.9e-10 39.9 4.2 1e-05 25.3 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat DUF1117 PF06547.7 CDI77509.1 - 0.79 9.8 4.6 0.31 11.1 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) CDK2AP PF09806.4 CDI77509.1 - 5.5 7.1 11.7 10 6.2 0.1 3.2 3 0 0 3 3 3 0 Cyclin-dependent kinase 2-associated protein DUF3446 PF11928.3 CDI77511.1 - 4.6 7.5 18.1 2.4 8.4 2.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) SDA1 PF05285.7 CDI77513.1 - 0.0027 17.0 5.8 0.0027 17.0 4.0 1.6 2 0 0 2 2 2 1 SDA1 PAT1 PF09770.4 CDI77513.1 - 7.3 4.6 37.3 1.4 7.0 10.5 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Peptidase_C2 PF00648.16 CDI77514.1 - 5.8e-23 81.3 0.0 5.1e-21 74.9 0.0 2.7 2 0 0 2 2 2 2 Calpain family cysteine protease Dala_Dala_lig_N PF01820.16 CDI77514.1 - 1.5 9.1 13.0 0.18 12.0 0.5 3.2 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus NodS PF05401.6 CDI77515.1 - 0.038 13.3 0.0 0.06 12.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Sin_N PF04801.8 CDI77515.1 - 0.18 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region PhyH PF05721.8 CDI77516.1 - 4.6e-07 30.0 0.0 1.9e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.11 CDI77516.1 - 0.041 13.5 0.0 0.11 12.1 0.0 1.6 1 1 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family DNA_pol_B PF00136.16 CDI77517.1 - 2e-47 162.0 0.0 3.7e-47 161.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.1 CDI77517.1 - 1.2e-11 44.4 4.2 1.2e-11 44.4 2.9 3.5 3 0 0 3 3 3 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo1 PF03104.14 CDI77517.1 - 0.0021 16.9 0.0 0.25 10.1 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain MRAP PF15183.1 CDI77518.1 - 0.11 12.0 0.1 0.24 11.0 0.1 1.5 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Mago-bind PF09282.5 CDI77518.1 - 0.26 10.9 1.8 6.4 6.4 0.1 2.4 2 0 0 2 2 2 0 Mago binding WLM PF08325.5 CDI77520.1 - 1e-06 28.7 0.3 5e-06 26.5 0.0 2.2 2 1 0 2 2 2 1 WLM domain DUF45 PF01863.12 CDI77520.1 - 1.2e-05 25.1 0.3 0.00018 21.3 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function DUF45 Mito_carr PF00153.22 CDI77521.1 - 3.8e-57 190.0 5.5 3.3e-25 87.6 0.0 4.4 3 1 0 3 3 3 3 Mitochondrial carrier protein RAB3GAP2_N PF14655.1 CDI77521.1 - 0.24 10.3 1.9 0.37 9.7 0.9 1.7 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus zf-C2H2_2 PF12756.2 CDI77523.1 - 1.6e-18 66.6 1.6 1.6e-18 66.6 1.1 2.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) eIF-3c_N PF05470.7 CDI77523.1 - 0.016 13.3 1.1 0.023 12.7 0.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus AMP-binding PF00501.23 CDI77524.1 - 4.5e-21 74.7 0.0 1.1e-16 60.3 0.0 3.3 3 1 0 3 3 3 3 AMP-binding enzyme PKD_channel PF08016.7 CDI77525.1 - 6e-17 61.1 16.0 2.1e-07 29.7 8.3 3.6 3 0 0 3 3 3 3 Polycystin cation channel Kinesin PF00225.18 CDI77526.1 - 1.8e-85 286.6 0.0 2.4e-43 148.1 0.0 2.4 1 1 1 2 2 2 2 Kinesin motor domain KIF1B PF12423.3 CDI77526.1 - 3.5e-05 23.7 0.1 0.00013 21.9 0.0 2.1 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.21 CDI77526.1 - 0.031 14.3 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 FHA domain Herpes_DNAp_acc PF04929.7 CDI77528.1 - 0.0023 16.9 0.6 0.0023 16.9 0.4 6.3 4 2 2 6 6 6 2 Herpes DNA replication accessory factor Mg_trans_NIPA PF05653.9 CDI77530.1 - 1.3e-21 76.8 7.1 1.9e-21 76.3 4.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.15 CDI77530.1 - 2e-05 24.6 4.8 2e-05 24.6 3.3 3.0 2 2 0 2 2 2 1 EamA-like transporter family EmrE PF13536.1 CDI77530.1 - 0.00072 19.7 2.4 0.00072 19.7 1.7 2.9 2 1 0 2 2 2 1 Multidrug resistance efflux transporter ERO1 PF04137.10 CDI77532.1 - 1.5e-25 90.0 11.2 1.9e-23 83.0 0.0 3.3 3 1 0 3 3 3 2 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Vps39_2 PF10367.4 CDI77532.1 - 0.057 13.6 0.2 0.057 13.6 0.2 3.8 4 1 0 4 4 4 0 Vacuolar sorting protein 39 domain 2 ArsA_ATPase PF02374.10 CDI77534.1 - 2.5e-55 187.6 0.6 3.4e-41 141.2 0.0 2.1 1 1 1 2 2 2 2 Anion-transporting ATPase Med25_VWA PF11265.3 CDI77534.1 - 0.03 13.3 0.1 0.07 12.1 0.1 1.7 1 1 1 2 2 2 0 Mediator complex subunit 25 von Willebrand factor type A CS PF04969.11 CDI77535.1 - 4.4e-08 33.5 0.0 1.9e-07 31.5 0.0 2.1 2 1 0 2 2 2 1 CS domain TatD_DNase PF01026.16 CDI77535.1 - 0.013 14.6 4.0 0.19 10.8 0.3 2.9 2 1 0 2 2 2 0 TatD related DNase U1snRNP70_N PF12220.3 CDI77535.1 - 2.7 8.3 15.5 0.96 9.8 2.0 2.9 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PIG-L PF02585.12 CDI77536.1 - 3e-21 76.2 0.0 2.2e-20 73.4 0.0 2.4 2 0 0 2 2 2 1 GlcNAc-PI de-N-acetylase Raftlin PF15250.1 CDI77536.1 - 0.00024 19.7 5.8 0.0016 17.0 0.1 2.1 2 0 0 2 2 2 2 Raftlin Kei1 PF08552.6 CDI77536.1 - 0.0026 17.4 9.6 0.016 14.9 0.0 3.2 3 0 0 3 3 3 1 Inositolphosphorylceramide synthase subunit Kei1 Pex14_N PF04695.8 CDI77536.1 - 0.0072 16.3 12.0 2.5 8.1 0.1 3.4 3 0 0 3 3 3 3 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_S49_N PF08496.5 CDI77536.1 - 0.059 13.1 12.9 0.039 13.7 1.4 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF2052 PF09747.4 CDI77536.1 - 0.1 12.4 21.1 0.44 10.4 4.4 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Serinc PF03348.10 CDI77536.1 - 0.82 8.3 9.1 3.2 6.3 1.4 2.4 2 0 0 2 2 2 0 Serine incorporator (Serinc) AAA_23 PF13476.1 CDI77536.1 - 2.1 8.6 16.3 0.57 10.4 0.6 2.2 2 0 0 2 2 2 0 AAA domain Suf PF05843.9 CDI77536.1 - 2.1 7.9 14.6 3.3 7.3 1.6 2.7 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Dala_Dala_lig_N PF01820.16 CDI77536.1 - 2.8 8.2 9.0 4.6 7.5 1.3 2.6 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_11 PF13086.1 CDI77536.1 - 3 7.3 18.3 0.27 10.7 2.8 2.3 2 0 0 2 2 2 0 AAA domain Peroxin-13_N PF04088.8 CDI77536.1 - 4 7.3 7.8 11 5.8 0.9 2.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region TFIIA PF03153.8 CDI77536.1 - 6.1 6.6 25.8 2.2 8.0 2.4 3.1 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Membralin PF09746.4 CDI77536.1 - 6.7 5.6 6.2 15 4.5 0.7 2.1 2 0 0 2 2 2 0 Tumour-associated protein Ctr PF04145.10 CDI77536.1 - 8.4 6.4 12.3 3.9 7.5 0.1 3.6 3 1 0 3 3 3 0 Ctr copper transporter family BCAS2 PF05700.6 CDI77537.1 - 2.7e-35 121.8 2.9 2.7e-35 121.8 2.0 2.4 3 0 0 3 3 3 1 Breast carcinoma amplified sequence 2 (BCAS2) MitoNEET_N PF10660.4 CDI77537.1 - 1.4 8.8 4.0 0.83 9.5 0.8 2.1 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus Ribosomal_L16 PF00252.13 CDI77538.1 - 1.2e-31 109.2 0.0 1.5e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e AAA_17 PF13207.1 CDI77539.1 - 0.00019 22.2 0.4 0.00066 20.4 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDI77539.1 - 0.00093 18.9 0.6 0.29 10.9 0.5 2.5 2 0 0 2 2 2 1 Part of AAA domain MobB PF03205.9 CDI77539.1 - 0.0017 18.0 0.1 0.0056 16.3 0.0 1.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CDI77539.1 - 0.0028 17.9 0.1 0.0047 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CDI77539.1 - 0.0056 16.8 0.2 0.018 15.2 0.1 1.8 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI77539.1 - 0.0063 16.5 0.2 0.009 16.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.1 CDI77539.1 - 0.0066 16.7 0.1 0.025 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CDI77539.1 - 0.012 15.5 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CDI77539.1 - 0.013 15.2 0.2 0.024 14.3 0.1 1.4 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.22 CDI77539.1 - 0.014 15.6 0.4 0.029 14.6 0.3 1.4 1 0 0 1 1 1 0 ABC transporter SRP54 PF00448.17 CDI77539.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.1 CDI77539.1 - 0.017 14.9 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CDI77539.1 - 0.022 14.7 0.6 0.049 13.5 0.4 1.6 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 CDI77539.1 - 0.023 14.2 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.1 CDI77539.1 - 0.027 14.6 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CDI77539.1 - 0.039 13.3 0.1 0.069 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CDI77539.1 - 0.044 13.4 0.1 0.099 12.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 CDI77539.1 - 0.059 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.10 CDI77539.1 - 0.065 11.9 0.1 0.091 11.4 0.1 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein CoaE PF01121.15 CDI77539.1 - 0.12 11.7 0.6 0.32 10.3 0.4 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase KAP_NTPase PF07693.9 CDI77539.1 - 0.12 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain UPF0079 PF02367.12 CDI77539.1 - 0.12 11.9 0.0 0.51 9.9 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Adeno_IVa2 PF02456.10 CDI77539.1 - 0.13 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein NB-ARC PF00931.17 CDI77539.1 - 0.15 10.9 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain ArgK PF03308.11 CDI77539.1 - 0.15 10.7 0.0 0.26 10.0 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_24 PF13479.1 CDI77539.1 - 0.18 11.3 0.3 0.32 10.5 0.2 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_M20 PF01546.23 CDI77540.1 - 8.8e-30 103.6 0.1 1.3e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDI77540.1 - 3.5e-10 39.5 0.0 7.6e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain IL13 PF03487.8 CDI77542.1 - 1.7 8.4 5.3 4.9 6.9 3.5 1.9 1 1 1 2 2 2 0 Interleukin-13 Peptidase_M16 PF00675.15 CDI77546.1 - 1.1e-48 164.7 0.0 2.1e-48 163.8 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDI77546.1 - 1.4e-37 129.1 0.0 2.9e-37 128.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain zf-trcl PF13451.1 CDI77546.1 - 0.066 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Probable zinc-binding domain Abhydrolase_5 PF12695.2 CDI77547.1 - 1.1e-19 70.6 0.0 1.1e-19 70.6 0.0 2.6 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI77547.1 - 9.2e-16 58.4 1.9 9.2e-16 58.4 1.3 2.9 2 2 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI77547.1 - 3.6e-05 23.4 0.2 0.0012 18.4 0.1 2.4 1 1 1 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.8 CDI77547.1 - 0.00036 20.0 0.0 0.001 18.5 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.3 CDI77547.1 - 0.00044 20.0 0.0 0.00097 18.9 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase UIM PF02809.15 CDI77547.1 - 0.0091 15.4 0.8 0.021 14.3 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin interaction motif Neur_chan_memb PF02932.11 CDI77547.1 - 1.4 8.7 4.2 3.2 7.5 2.9 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Actin PF00022.14 CDI77548.1 - 2.2e-46 158.0 0.0 8.7e-29 100.1 0.0 2.0 1 1 1 2 2 2 2 Actin Mito_fiss_reg PF05308.6 CDI77549.1 - 0.073 12.4 5.6 0.073 12.4 3.9 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator PHD_2 PF13831.1 CDI77550.1 - 6.8e-06 25.3 13.1 0.0003 20.0 0.4 4.1 4 0 0 4 4 4 2 PHD-finger SR-25 PF10500.4 CDI77550.1 - 2.2e-05 24.0 18.1 5.1e-05 22.8 6.9 14.7 12 3 3 15 15 15 4 Nuclear RNA-splicing-associated protein PHD PF00628.24 CDI77550.1 - 0.046 13.4 0.0 0.031 13.9 1.3 5.6 7 0 0 7 7 7 0 PHD-finger CT47 PF15623.1 CDI77551.1 - 1.2 8.8 46.4 1 9.0 13.6 2.7 2 0 0 2 2 2 0 Cancer/testis gene family 47 FLO_LFY PF01698.11 CDI77551.1 - 2.4 6.9 16.4 1.5 7.5 5.2 2.2 2 0 0 2 2 2 0 Floricaula / Leafy protein PAT1 PF09770.4 CDI77551.1 - 2.7 6.1 31.9 3.5 5.7 22.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI77551.1 - 2.9 5.9 39.0 3.8 5.5 27.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal HNOBA PF07701.9 CDI77551.1 - 4.4 6.4 11.0 1.2 8.3 0.5 2.3 2 0 0 2 2 2 0 Heme NO binding associated Merozoite_SPAM PF07133.6 CDI77551.1 - 5.8 6.7 15.7 4.6 7.0 3.1 2.2 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Peptidase_S15 PF02129.13 CDI77551.1 - 7.9 5.8 14.4 1.2 8.4 4.1 2.3 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) SOG2 PF10428.4 CDI77553.1 - 0.0038 15.9 1.6 0.0043 15.7 1.1 1.0 1 0 0 1 1 1 1 RAM signalling pathway protein HHH_8 PF14716.1 CDI77554.1 - 0.027 14.6 0.5 0.049 13.8 0.3 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain Mrr_N PF14338.1 CDI77554.1 - 0.034 14.2 0.1 0.034 14.2 0.0 2.1 1 1 1 2 2 2 0 Mrr N-terminal domain Ctr PF04145.10 CDI77554.1 - 0.098 12.6 6.8 0.34 10.9 0.1 2.1 2 0 0 2 2 2 0 Ctr copper transporter family TPR_14 PF13428.1 CDI77554.1 - 0.13 12.9 7.7 7.9 7.4 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat Pol_alpha_B_N PF08418.5 CDI77554.1 - 0.33 10.4 14.6 0.45 10.0 10.1 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Borrelia_P83 PF05262.6 CDI77554.1 - 0.35 9.0 6.4 0.39 8.9 4.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FPN1 PF06963.7 CDI77554.1 - 0.42 8.9 3.7 0.71 8.1 2.5 1.3 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Ribosomal_L6e PF01159.14 CDI77554.1 - 0.74 10.0 4.2 1.2 9.3 2.9 1.4 1 0 0 1 1 1 0 Ribosomal protein L6e Metal_resist PF13801.1 CDI77554.1 - 0.83 9.6 11.3 1.4 8.9 7.8 1.3 1 0 0 1 1 1 0 Heavy-metal resistance DUF4407 PF14362.1 CDI77554.1 - 1.1 8.1 7.7 1.4 7.8 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prp18 PF02840.10 CDI77554.1 - 1.4 8.6 8.5 0.13 12.0 2.8 1.5 2 0 0 2 2 2 0 Prp18 domain DUF1003 PF06210.6 CDI77554.1 - 1.9 8.4 5.7 3.4 7.6 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Apc15p PF05841.6 CDI77554.1 - 2.1 9.1 18.9 1.4 9.6 4.1 2.2 2 0 0 2 2 2 0 Apc15p protein DUF4175 PF13779.1 CDI77554.1 - 2.5 5.6 18.3 3.3 5.3 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Peptidase_S46 PF10459.4 CDI77554.1 - 2.7 6.2 8.7 3.9 5.7 6.0 1.3 1 0 0 1 1 1 0 Peptidase S46 FlaG PF03646.10 CDI77554.1 - 4.2 7.5 16.3 0.52 10.4 6.9 2.2 2 0 0 2 2 2 0 FlaG protein SseC PF04888.7 CDI77554.1 - 4.5 6.5 15.2 6.2 6.0 10.6 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF3366 PF11846.3 CDI77554.1 - 5.1 6.9 7.0 8.3 6.2 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) Pro_CA PF00484.14 CDI77554.1 - 9.1 6.2 7.6 6.5 6.7 4.2 1.5 1 1 1 2 2 2 0 Carbonic anhydrase Syntaxin PF00804.20 CDI77555.1 - 4.2e-06 26.8 4.1 4.3e-06 26.8 1.0 2.1 2 0 0 2 2 2 1 Syntaxin Sigma70_ner PF04546.8 CDI77555.1 - 0.046 13.3 4.3 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region Med15 PF09606.5 CDI77557.1 - 1.9 6.5 70.4 2.4 6.2 48.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF2A PF08662.6 CDI77559.1 - 1.2e-29 103.4 5.1 4.1e-26 91.9 0.8 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.17 CDI77559.1 - 6.9e-05 22.3 0.0 0.00017 21.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 CDI77559.1 - 0.0035 17.1 0.2 18 5.3 0.0 4.3 5 0 0 5 5 5 1 WD domain, G-beta repeat RRM_5 PF13893.1 CDI77559.1 - 0.0041 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YlqD PF11068.3 CDI77559.1 - 0.16 12.0 3.7 0.33 10.9 2.6 1.5 1 0 0 1 1 1 0 YlqD protein SR-25 PF10500.4 CDI77560.1 - 0.0006 19.3 10.4 0.0006 19.3 7.2 17.3 10 7 5 15 15 15 2 Nuclear RNA-splicing-associated protein eIF-3_zeta PF05091.7 CDI77561.1 - 2.1e-45 155.3 0.5 4.2e-31 108.1 0.0 3.0 2 1 1 3 3 3 3 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ATP_bind_1 PF03029.12 CDI77562.1 - 5.5e-55 186.5 0.0 1.3e-54 185.2 0.0 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 CDI77562.1 - 2.2e-05 25.2 0.7 0.00013 22.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CDI77562.1 - 6.3e-05 22.4 0.0 0.00022 20.6 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 CDI77562.1 - 0.00063 20.0 1.0 0.0085 16.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDI77562.1 - 0.0013 18.8 0.0 0.0049 17.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI77562.1 - 0.0024 17.8 0.0 0.0024 17.8 0.0 3.8 2 1 2 4 4 4 1 AAA ATPase domain PduV-EutP PF10662.4 CDI77562.1 - 0.0025 17.2 0.0 0.046 13.2 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 CDI77562.1 - 0.037 13.9 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 CDI77563.1 - 6.7e-18 64.7 0.0 1.1e-16 60.7 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77563.1 - 2.7e-07 29.9 0.0 4.1e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDI77563.1 - 0.026 13.4 0.0 0.069 12.0 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Tom37_C PF11801.3 CDI77563.1 - 0.093 12.5 0.3 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 Tom37 C-terminal domain Pkinase PF00069.20 CDI77564.1 - 2.1e-17 63.1 1.2 4.3e-17 62.1 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain Kinase-like PF14531.1 CDI77564.1 - 5.2e-08 32.2 0.3 1.4e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_Tyr PF07714.12 CDI77564.1 - 2.6e-05 23.4 0.2 0.00011 21.3 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 CDI77564.1 - 0.0011 18.0 1.3 0.0097 14.9 0.0 2.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Utp14 PF04615.8 CDI77568.1 - 0.15 10.2 43.5 0.2 9.8 30.2 1.2 1 0 0 1 1 1 0 Utp14 protein Hid1 PF12722.2 CDI77568.1 - 1.3 6.5 29.4 1.6 6.2 20.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PLRV_ORF5 PF01690.12 CDI77568.1 - 3.4 6.7 35.9 4.3 6.3 24.9 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Daxx PF03344.10 CDI77568.1 - 6.5 5.1 48.8 8.3 4.7 33.8 1.1 1 0 0 1 1 1 0 Daxx Family Chorion_2 PF03964.10 CDI77568.1 - 9.3 6.8 14.8 20 5.8 10.3 1.6 1 1 0 1 1 1 0 Chorion family 2 Glyco_hydro_31 PF01055.21 CDI77569.1 - 2.2e-65 221.2 0.1 1.6e-59 201.9 0.0 3.8 2 1 1 3 3 3 2 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CDI77569.1 - 3.5e-05 23.5 0.0 7.5e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like Ycf1 PF05758.7 CDI77571.1 - 9.5 3.7 9.1 12 3.4 6.3 1.1 1 0 0 1 1 1 0 Ycf1 Apo-CII PF05355.6 CDI77577.1 - 8.9 6.2 8.2 0.72 9.7 0.8 2.5 2 1 1 3 3 3 0 Apolipoprotein C-II tRNA-synt_2 PF00152.15 CDI77579.1 - 9.1e-72 241.6 0.0 1.3e-71 241.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 CDI77579.1 - 0.001 18.3 0.2 1 8.4 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) P12 PF12669.2 CDI77580.1 - 0.02 15.0 3.2 0.02 15.0 2.2 6.7 5 2 1 6 6 6 0 Virus attachment protein p12 family Cohesin_HEAT PF12765.2 CDI77581.1 - 0.0013 18.6 0.5 0.47 10.4 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat associated with sister chromatid cohesion RICTOR_N PF14664.1 CDI77582.1 - 7.6e-06 24.7 2.2 0.066 11.7 0.0 3.7 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, N-term HEAT PF02985.17 CDI77582.1 - 1.2 9.3 7.9 9.6 6.5 0.7 3.6 2 0 0 2 2 2 0 HEAT repeat ATP-synt_ab_C PF00306.22 CDI77586.1 - 1.4e-19 70.6 0.6 2e-19 70.1 0.4 1.3 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ABC1 PF03109.11 CDI77587.1 - 5.6e-26 90.8 0.0 2.1e-25 89.0 0.0 2.1 1 0 0 1 1 1 1 ABC1 family OmpH PF03938.9 CDI77587.1 - 0.1 12.5 0.1 0.1 12.5 0.0 6.7 4 2 2 6 6 6 0 Outer membrane protein (OmpH-like) Activator_LAG-3 PF11498.3 CDI77588.1 - 0.0013 17.6 4.1 0.0013 17.6 2.9 9.7 8 3 2 10 10 10 2 Transcriptional activator LAG-3 ISN1 PF06437.6 CDI77591.1 - 3.8e-37 127.9 0.1 3.8e-37 127.9 0.0 1.6 2 0 0 2 2 2 1 IMP-specific 5'-nucleotidase Rtf2 PF04641.7 CDI77591.1 - 0.38 9.9 9.8 0.36 9.9 0.0 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Tim54 PF11711.3 CDI77591.1 - 0.38 9.2 3.8 3.1 6.2 0.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF2201_N PF13203.1 CDI77591.1 - 0.87 8.7 19.8 0.03 13.5 0.6 2.8 2 0 0 2 2 2 0 Putative metallopeptidase domain Spt20 PF12090.3 CDI77591.1 - 9.5 5.5 13.4 28 4.0 7.6 2.2 2 0 0 2 2 2 0 Spt20 family RAP1 PF07218.6 CDI77593.1 - 0.85 7.6 11.9 1.1 7.2 8.3 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RVT_1 PF00078.22 CDI77594.1 - 0.00015 21.1 0.0 0.00026 20.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNA_pol_Rpb1_2 PF00623.15 CDI77600.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 2 SAPS PF04499.10 CDI77600.1 - 0.28 9.7 14.6 0.42 9.1 10.1 1.3 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein Gly-zipper_Omp PF13488.1 CDI77600.1 - 0.47 10.1 34.7 1 9.0 24.0 1.5 1 0 0 1 1 1 0 Glycine zipper Bacteriocin_IIc PF10439.4 CDI77600.1 - 0.8 9.8 20.1 1.6 8.8 13.9 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Rick_17kDa_Anti PF05433.10 CDI77600.1 - 3.2 7.5 37.6 5.1 6.8 26.0 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.1 CDI77600.1 - 7 6.2 46.7 1.2 8.7 29.6 1.7 2 0 0 2 2 2 0 YMGG-like Gly-zipper DUF4175 PF13779.1 CDI77600.1 - 10 3.7 62.4 0.19 9.3 24.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Epimerase PF01370.16 CDI77601.1 - 1.4e-31 109.7 0.0 8.8e-26 90.7 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CDI77601.1 - 6.2e-06 25.3 0.0 9.8e-06 24.6 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 CDI77601.1 - 0.0012 17.7 0.1 0.0025 16.7 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 CDI77601.1 - 0.0029 16.5 0.3 0.016 14.1 0.0 1.9 1 1 1 2 2 2 1 Male sterility protein Ax_dynein_light PF10211.4 CDI77602.1 - 0.36 10.6 25.8 0.36 10.6 7.7 4.0 4 0 0 4 4 4 0 Axonemal dynein light chain Phage_GP20 PF06810.6 CDI77602.1 - 0.51 9.7 21.5 0.36 10.2 5.9 4.2 3 1 1 4 4 4 0 Phage minor structural protein GP20 DUF342 PF03961.8 CDI77602.1 - 2.6 6.3 17.3 0.9 7.8 0.0 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF342) Tup_N PF08581.5 CDI77602.1 - 4.2 7.6 20.0 0.099 12.8 5.8 3.3 3 0 0 3 3 3 0 Tup N-terminal BRCT PF00533.21 CDI77603.1 - 0.011 15.8 0.5 1 9.5 0.0 3.5 3 1 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain TIP49 PF06068.8 CDI77604.1 - 1.1e-121 406.3 3.8 2.5e-53 181.2 0.3 3.0 1 1 2 3 3 3 3 TIP49 C-terminus RuvB_N PF05496.7 CDI77604.1 - 0.00046 19.2 0.1 0.014 14.4 0.1 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 CDI77604.1 - 0.0014 18.8 0.1 0.0038 17.4 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CDI77604.1 - 0.0028 17.0 0.0 0.0058 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 CDI77604.1 - 0.13 11.9 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 gag-asp_proteas PF13975.1 CDI77605.1 - 0.0011 18.6 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 CDI77605.1 - 0.011 15.6 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 CDI77605.1 - 0.059 13.8 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Glt_symporter PF03616.9 CDI77607.1 - 0.092 11.2 0.1 0.15 10.5 0.1 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF4175 PF13779.1 CDI77607.1 - 6.4 4.3 19.1 12 3.4 13.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SpoVR PF04293.8 CDI77610.1 - 0.013 13.8 2.9 0.016 13.5 2.0 1.1 1 0 0 1 1 1 0 SpoVR like protein Spt20 PF12090.3 CDI77610.1 - 0.015 14.6 4.5 0.018 14.3 3.1 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.9 CDI77610.1 - 0.019 14.6 5.3 0.021 14.5 3.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Fork_head PF00250.13 CDI77610.1 - 0.043 13.8 0.4 0.064 13.3 0.3 1.2 1 0 0 1 1 1 0 Fork head domain DUF2347 PF09804.4 CDI77610.1 - 0.064 12.5 2.4 0.081 12.1 1.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Serinc PF03348.10 CDI77610.1 - 0.24 10.0 2.2 0.25 10.0 1.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) UPF0560 PF10577.4 CDI77610.1 - 0.62 8.2 9.8 0.76 7.9 6.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF3306 PF11748.3 CDI77610.1 - 3.3 8.3 12.1 7.5 7.2 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) YqfQ PF14181.1 CDI77610.1 - 8.8 6.3 15.8 1.4 8.8 4.6 2.3 2 0 0 2 2 2 0 YqfQ-like protein dCMP_cyt_deam_2 PF08211.6 CDI77612.1 - 2.7e-12 46.7 3.1 2.7e-12 46.7 2.1 2.9 3 1 0 3 3 3 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 PF00383.17 CDI77612.1 - 2.9e-06 26.8 12.3 5.7e-05 22.6 1.4 2.8 2 1 1 3 3 3 2 Cytidine and deoxycytidylate deaminase zinc-binding region Band_3_cyto PF07565.8 CDI77612.1 - 0.029 13.8 2.5 0.036 13.5 1.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SpaB_C PF14028.1 CDI77612.1 - 2.9 7.3 29.3 1.2 8.6 10.2 2.1 2 0 0 2 2 2 0 SpaB C-terminal domain Adaptin_N PF01602.15 CDI77613.1 - 6e-32 110.6 25.6 2.2e-26 92.3 1.1 6.2 4 2 0 5 5 5 4 Adaptin N terminal region HD-ZIP_N PF04618.7 CDI77614.1 - 0.053 14.0 3.7 0.055 14.0 2.6 1.1 1 0 0 1 1 1 0 HD-ZIP protein N terminus YqfQ PF14181.1 CDI77614.1 - 0.1 12.6 14.2 0.12 12.4 9.9 1.1 1 0 0 1 1 1 0 YqfQ-like protein SR-25 PF10500.4 CDI77614.1 - 0.14 11.5 10.6 0.16 11.3 7.3 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Vfa1 PF08432.5 CDI77614.1 - 0.23 11.4 15.2 0.26 11.2 10.5 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pal1 PF08316.6 CDI77614.1 - 0.26 11.7 7.3 0.3 11.5 5.1 1.0 1 0 0 1 1 1 0 Pal1 cell morphology protein SUFU_C PF12470.3 CDI77614.1 - 0.36 10.3 5.9 0.4 10.2 4.1 1.0 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain DUF4392 PF14336.1 CDI77614.1 - 0.47 9.2 2.5 0.46 9.2 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) FimP PF09766.4 CDI77614.1 - 0.6 9.1 24.3 0.66 8.9 16.8 1.0 1 0 0 1 1 1 0 Fms-interacting protein SelP_N PF04592.9 CDI77614.1 - 0.79 9.0 11.1 0.83 8.9 7.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NARP1 PF12569.3 CDI77614.1 - 0.85 8.2 17.7 0.87 8.2 12.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Med15 PF09606.5 CDI77614.1 - 1 7.5 39.5 1.1 7.3 27.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI77614.1 - 1.1 7.3 29.1 1.2 7.3 20.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_U57 PF05582.7 CDI77614.1 - 1.1 8.1 11.5 1.2 8.0 8.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 FLO_LFY PF01698.11 CDI77614.1 - 1.1 7.9 13.5 1.2 7.9 9.4 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein GAGA_bind PF06217.7 CDI77614.1 - 1.2 9.0 11.8 1.2 9.0 8.2 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Rtf2 PF04641.7 CDI77614.1 - 1.3 8.2 15.0 1.4 8.0 10.4 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Peptidase_S49_N PF08496.5 CDI77614.1 - 1.3 8.8 13.8 1.4 8.6 9.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal AIF_C PF14721.1 CDI77614.1 - 1.3 9.2 12.2 1.5 9.0 8.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pex14_N PF04695.8 CDI77614.1 - 1.6 8.7 19.7 1.8 8.6 13.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM60A PF15396.1 CDI77614.1 - 1.6 8.3 9.4 1.8 8.2 6.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF1764 PF08576.5 CDI77614.1 - 1.7 9.4 16.1 1.9 9.2 11.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF4557 PF15101.1 CDI77614.1 - 1.9 8.2 24.1 2 8.1 16.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) P5-ATPase PF12409.3 CDI77614.1 - 2 8.2 6.2 2.4 8.0 4.3 1.0 1 0 0 1 1 1 0 P5-type ATPase cation transporter Band_3_cyto PF07565.8 CDI77614.1 - 2.1 7.8 12.3 2.2 7.7 8.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3994 PF13159.1 CDI77614.1 - 2.2 8.5 8.4 2.9 8.2 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) Baculo_PP31 PF05311.6 CDI77614.1 - 2.2 7.4 14.1 2.4 7.3 9.8 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2203 PF09969.4 CDI77614.1 - 2.3 8.4 10.9 2.5 8.3 7.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Gastrin PF00918.12 CDI77614.1 - 2.3 9.0 17.5 2.7 8.8 12.1 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family DDHD PF02862.12 CDI77614.1 - 2.5 7.8 12.9 2.6 7.7 8.9 1.0 1 0 0 1 1 1 0 DDHD domain FNIP_N PF14636.1 CDI77614.1 - 2.6 8.5 12.8 3 8.3 8.9 1.0 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus CKAP2_C PF15297.1 CDI77614.1 - 2.6 6.7 15.5 2.8 6.6 10.8 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus PcfK PF14058.1 CDI77614.1 - 2.6 8.1 18.3 2.7 8.1 12.7 1.1 1 0 0 1 1 1 0 PcfK-like protein Suf PF05843.9 CDI77614.1 - 2.7 7.6 17.9 2.9 7.5 12.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Nop53 PF07767.6 CDI77614.1 - 2.7 6.9 22.8 3.1 6.6 15.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Bac_luciferase PF00296.15 CDI77614.1 - 3 6.8 7.7 3.6 6.6 5.3 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase APG6 PF04111.7 CDI77614.1 - 3.1 6.7 18.9 3.3 6.6 13.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 R_equi_Vir PF05526.6 CDI77614.1 - 3.2 7.3 9.3 3.7 7.1 6.5 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF1510 PF07423.6 CDI77614.1 - 3.8 6.8 17.5 4.4 6.6 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Raftlin PF15250.1 CDI77614.1 - 3.8 5.9 13.0 4.2 5.7 9.0 1.0 1 0 0 1 1 1 0 Raftlin Tim54 PF11711.3 CDI77614.1 - 3.8 5.9 11.8 4 5.9 8.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SprA-related PF12118.3 CDI77614.1 - 3.9 6.7 37.1 4.4 6.5 25.7 1.0 1 0 0 1 1 1 0 SprA-related family DUF4011 PF13195.1 CDI77614.1 - 4 7.4 10.7 4.2 7.3 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) Zip PF02535.17 CDI77614.1 - 4 6.3 8.5 4.1 6.3 5.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RIC3 PF15361.1 CDI77614.1 - 4 7.6 13.1 4.5 7.4 9.0 1.1 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Spore_coat_CotO PF14153.1 CDI77614.1 - 4.2 6.7 22.3 4.9 6.5 15.4 1.0 1 0 0 1 1 1 0 Spore coat protein CotO FHIPEP PF00771.15 CDI77614.1 - 4.3 5.5 8.7 3.8 5.7 6.0 1.1 1 0 0 1 1 1 0 FHIPEP family Dala_Dala_lig_N PF01820.16 CDI77614.1 - 4.4 7.6 8.1 5.2 7.3 5.6 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus Ctr PF04145.10 CDI77614.1 - 4.8 7.2 8.5 5.5 7.0 5.9 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Asp-B-Hydro_N PF05279.6 CDI77614.1 - 4.8 6.9 13.4 5.5 6.7 9.3 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Neur_chan_memb PF02932.11 CDI77614.1 - 5.4 6.8 7.9 5.6 6.7 5.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PH_4 PF15404.1 CDI77614.1 - 6.2 6.3 11.2 6.7 6.2 7.7 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain CDC45 PF02724.9 CDI77614.1 - 6.2 4.7 14.5 7 4.5 10.1 1.0 1 0 0 1 1 1 0 CDC45-like protein AUX_IAA PF02309.11 CDI77614.1 - 6.6 6.4 13.1 7.2 6.2 9.1 1.0 1 0 0 1 1 1 0 AUX/IAA family Peptidase_S15 PF02129.13 CDI77614.1 - 6.7 6.0 10.7 7 5.9 7.4 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Gag_spuma PF03276.9 CDI77614.1 - 6.7 4.9 24.6 6.8 4.8 17.0 1.0 1 0 0 1 1 1 0 Spumavirus gag protein FAM176 PF14851.1 CDI77614.1 - 7 6.3 7.9 7.5 6.2 5.5 1.2 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.7 CDI77614.1 - 7.1 6.4 17.8 7.6 6.3 12.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MDFI PF15316.1 CDI77614.1 - 7.1 6.5 8.7 8.1 6.4 6.0 1.1 1 0 0 1 1 1 0 MyoD family inhibitor DUF3408 PF11888.3 CDI77614.1 - 7.3 6.5 12.9 8.8 6.2 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF3276 PF11680.3 CDI77614.1 - 7.4 6.3 10.4 8.5 6.1 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) CDK5_activator PF03261.10 CDI77614.1 - 8.3 5.6 12.0 8.4 5.6 8.3 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Gti1_Pac2 PF09729.4 CDI77614.1 - 8.5 6.2 10.7 9.7 6.0 7.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family CPSF100_C PF13299.1 CDI77614.1 - 9 6.4 12.7 9.8 6.3 8.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SeqA PF03925.8 CDI77614.1 - 9.6 5.8 12.4 9.9 5.8 8.6 1.1 1 0 0 1 1 1 0 SeqA protein EMP24_GP25L PF01105.19 CDI77614.1 - 9.6 5.8 12.2 12 5.5 8.5 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD CRF1 PF10380.4 CDI77614.1 - 9.6 6.5 8.7 11 6.4 6.0 1.1 1 0 0 1 1 1 0 Transcription factor CRF1 DUF2072 PF09845.4 CDI77614.1 - 9.8 6.1 8.8 13 5.7 6.1 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Suf PF05843.9 CDI77615.1 - 0.0032 17.2 15.9 0.0041 16.8 11.0 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Corona_nucleoca PF00937.13 CDI77615.1 - 0.016 14.1 11.6 0.019 13.9 8.1 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein NifQ PF04891.7 CDI77615.1 - 0.022 14.9 3.0 0.022 14.9 2.1 1.9 1 1 0 2 2 2 0 NifQ TFIIA PF03153.8 CDI77615.1 - 0.025 14.4 24.6 0.031 14.1 17.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF605 PF04652.11 CDI77615.1 - 0.032 13.6 21.7 0.037 13.4 15.0 1.1 1 0 0 1 1 1 0 Vta1 like eIF-3c_N PF05470.7 CDI77615.1 - 0.22 9.5 4.8 0.28 9.2 3.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Bul1_N PF04425.7 CDI77615.1 - 0.55 8.7 9.3 0.69 8.3 6.4 1.1 1 0 0 1 1 1 0 Bul1 N terminus DDHD PF02862.12 CDI77615.1 - 1 9.1 13.7 1.4 8.6 9.5 1.1 1 0 0 1 1 1 0 DDHD domain Dehydrin PF00257.14 CDI77615.1 - 1.1 9.6 11.2 5 7.4 2.1 2.3 2 0 0 2 2 2 0 Dehydrin PAT1 PF09770.4 CDI77615.1 - 1.2 7.3 27.0 1.3 7.1 18.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DivIC PF04977.10 CDI77615.1 - 1.4 8.4 12.3 2.4 7.6 8.5 1.3 1 0 0 1 1 1 0 Septum formation initiator Vfa1 PF08432.5 CDI77615.1 - 2 8.4 12.4 3 7.8 8.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.7 CDI77615.1 - 2.1 8.1 12.0 3.1 7.6 8.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.4 CDI77615.1 - 2.4 6.8 13.0 3.5 6.3 9.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain MFMR PF07777.6 CDI77615.1 - 3.5 7.5 19.4 0.024 14.5 7.1 1.9 2 0 0 2 2 2 0 G-box binding protein MFMR Peptidase_S64 PF08192.6 CDI77615.1 - 3.7 5.7 12.9 4.6 5.4 8.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Neur_chan_memb PF02932.11 CDI77615.1 - 4.9 6.9 9.3 7.6 6.3 6.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.12 CDI77615.1 - 6.6 5.4 13.8 9.1 4.9 9.5 1.2 1 0 0 1 1 1 0 Presenilin Med15 PF09606.5 CDI77615.1 - 9.1 4.3 43.6 11 4.0 30.2 1.2 1 1 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.4 CDI77615.1 - 9.5 5.6 28.5 24 4.3 19.7 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_C14 PF00656.17 CDI77616.1 - 0.00041 20.1 0.0 0.00041 20.1 0.0 3.2 3 0 0 3 3 3 1 Caspase domain SR-25 PF10500.4 CDI77616.1 - 0.0066 15.9 8.6 0.0066 15.9 5.9 6.9 4 2 1 6 6 6 1 Nuclear RNA-splicing-associated protein CKS PF01111.14 CDI77617.1 - 1.6e-12 47.0 0.3 4.7e-05 23.1 0.0 2.4 2 0 0 2 2 2 2 Cyclin-dependent kinase regulatory subunit Suf PF05843.9 CDI77617.1 - 0.36 10.5 17.8 0.01 15.5 6.5 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI77617.1 - 8.9 4.4 57.1 0.43 8.7 27.8 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Ribosomal_L15e PF00827.12 CDI77618.1 - 3.6e-89 297.3 11.7 4.1e-89 297.1 8.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 Methyltransf_12 PF08242.7 CDI77621.1 - 7.5e-10 39.1 0.3 1.2e-06 28.8 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 CDI77621.1 - 4.2e-06 27.3 4.0 1.3e-05 25.7 2.8 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI77621.1 - 5.9e-06 26.0 0.0 0.00068 19.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDI77621.1 - 3.6e-05 23.2 0.1 0.0001 21.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CDI77621.1 - 0.00017 21.8 4.2 0.0066 16.8 0.1 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI77621.1 - 0.0002 21.7 5.1 0.014 15.8 0.0 3.5 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI77621.1 - 0.00032 20.3 0.0 0.00082 18.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 CDI77621.1 - 0.055 12.6 0.0 0.14 11.2 0.0 1.9 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_26 PF13659.1 CDI77621.1 - 0.064 13.2 19.8 46 4.0 13.7 3.1 1 1 0 1 1 1 0 Methyltransferase domain Hamartin PF04388.7 CDI77621.1 - 0.19 10.3 4.0 0.25 9.9 2.8 1.2 1 0 0 1 1 1 0 Hamartin protein DUF3273 PF11677.3 CDI77623.1 - 3.3e-76 256.0 6.5 3.8e-76 255.8 4.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) DUF2568 PF10823.3 CDI77623.1 - 0.01 16.0 0.7 0.031 14.5 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2568) Exo_endo_phos PF03372.18 CDI77625.1 - 1e-13 51.8 0.0 1.7e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TPT PF03151.11 CDI77626.1 - 6.5e-05 22.6 17.2 0.00013 21.6 1.2 2.8 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 CDI77626.1 - 0.0051 16.8 7.6 0.0051 16.8 5.3 2.5 3 0 0 3 3 3 1 EamA-like transporter family SAGA-Tad1 PF12767.2 CDI77626.1 - 0.12 12.0 8.6 0.21 11.1 6.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit FliT PF05400.8 CDI77627.1 - 0.004 17.5 4.4 0.004 17.5 3.0 3.0 3 0 0 3 3 3 1 Flagellar protein FliT DUF1183 PF06682.7 CDI77627.1 - 0.012 15.2 5.6 0.013 15.1 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Herpes_DNAp_acc PF04929.7 CDI77627.1 - 0.21 10.4 11.2 0.26 10.2 7.7 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF2749 PF10907.3 CDI77627.1 - 0.81 9.6 3.7 0.42 10.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2749) PAT1 PF09770.4 CDI77627.1 - 2.3 6.3 31.7 2.6 6.1 22.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.14 CDI77627.1 - 2.7 8.4 11.6 7 7.1 3.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Band_3_cyto PF07565.8 CDI77627.1 - 4.4 6.7 10.1 6.4 6.1 7.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TFIIA PF03153.8 CDI77627.1 - 7.3 6.3 23.1 9.2 6.0 16.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.2 CDI77627.1 - 9.5 3.7 10.3 10 3.6 7.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DNA_primase_S PF01896.14 CDI77629.1 - 3.5e-35 120.9 0.0 6.2e-35 120.1 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit tRNA-synt_1 PF00133.17 CDI77630.1 - 1e-191 638.0 0.0 1e-191 638.0 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CDI77630.1 - 2.2e-24 85.9 0.0 5.6e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CDI77630.1 - 2.8e-19 69.0 8.7 5.2e-09 35.2 0.0 3.6 4 0 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 CDI77630.1 - 3.2e-05 23.1 2.5 3.3e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain PAT1 PF09770.4 CDI77630.1 - 0.084 11.1 30.5 0.14 10.3 21.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Alba PF01918.16 CDI77630.1 - 0.12 11.9 0.3 27 4.4 0.0 2.9 2 0 0 2 2 2 0 Alba Pex14_N PF04695.8 CDI77630.1 - 0.54 10.2 17.8 1.3 9.0 12.3 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region VIT1 PF01988.14 CDI77630.1 - 2.7 7.4 4.5 47 3.3 2.8 2.4 2 0 0 2 2 2 0 VIT family Med15 PF09606.5 CDI77630.1 - 6.6 4.8 49.1 11 4.0 34.1 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peptidase_S49_N PF08496.5 CDI77630.1 - 7.6 6.3 12.5 2.7 7.7 6.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal 7tm_2 PF00002.19 CDI77631.1 - 0.28 10.2 1.1 13 4.8 0.1 2.7 2 0 0 2 2 2 0 7 transmembrane receptor (Secretin family) GNAT_acetyltr_2 PF13718.1 CDI77632.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF4330 PF14221.1 CDI77635.1 - 0.035 13.9 0.9 0.049 13.4 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) PfUIS3 PF11567.3 CDI77635.1 - 0.037 14.1 1.5 0.066 13.3 1.1 1.4 1 0 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein Drc1-Sld2 PF11719.3 CDI77639.1 - 0.0025 16.9 1.9 0.0039 16.3 1.3 1.4 1 0 0 1 1 1 1 DNA replication and checkpoint protein DivIVA PF05103.8 CDI77639.1 - 5.9 6.9 7.9 0.97 9.4 0.4 3.0 3 0 0 3 3 3 0 DivIVA protein AAA PF00004.24 CDI77641.1 - 2.2e-21 76.4 0.0 3.1e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 CDI77641.1 - 0.0021 17.8 0.0 0.0044 16.8 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain WD40 PF00400.27 CDI77644.1 - 7.7e-16 57.2 8.4 4.3e-06 26.4 0.5 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat OmpH PF03938.9 CDI77644.1 - 0.28 11.0 4.1 0.48 10.3 2.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FliD_N PF02465.13 CDI77644.1 - 0.5 10.7 4.8 1.5 9.2 3.3 1.9 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF4175 PF13779.1 CDI77644.1 - 1.2 6.7 11.1 1.7 6.2 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Sugarporin_N PF11471.3 CDI77644.1 - 1.4 8.5 8.0 2.9 7.5 5.6 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension RBD-FIP PF09457.5 CDI77644.1 - 6.3 6.6 9.3 10 5.9 6.5 1.3 1 0 0 1 1 1 0 FIP domain TYW3 PF02676.9 CDI77645.1 - 2.9e-35 121.2 7.9 6.3e-33 113.6 5.5 3.5 1 1 0 1 1 1 1 Methyltransferase TYW3 Met_10 PF02475.11 CDI77645.1 - 2.5e-15 56.6 0.0 4.9e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.9 CDI77645.1 - 0.00062 19.1 0.2 0.0019 17.5 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase small domain FTCD PF02971.9 CDI77645.1 - 0.13 11.9 0.0 0.32 10.5 0.0 1.7 1 1 0 1 1 1 0 Formiminotransferase domain FancD2 PF14631.1 CDI77646.1 - 0.042 10.9 0.2 0.051 10.6 0.1 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease AAA_23 PF13476.1 CDI77647.1 - 2.1e-23 83.7 6.4 2.1e-23 83.7 4.4 9.6 1 1 5 6 6 6 1 AAA domain SMC_N PF02463.14 CDI77647.1 - 5.2e-10 38.9 10.9 5.6e-06 25.7 0.0 5.1 3 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDI77647.1 - 1.2e-08 35.3 0.0 0.0034 17.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 CDI77647.1 - 1.6e-06 27.4 0.0 0.00014 21.0 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 CDI77647.1 - 0.0004 20.6 0.0 0.0004 20.6 0.0 9.0 4 2 2 6 6 6 2 ABC transporter AAA_29 PF13555.1 CDI77647.1 - 0.00091 18.7 0.0 0.0022 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 CDI77647.1 - 0.056 11.9 0.0 0.056 11.9 0.0 7.8 3 2 4 8 8 8 0 AAA domain AAA_16 PF13191.1 CDI77647.1 - 0.1 12.5 0.0 0.1 12.5 0.0 9.2 3 2 2 5 5 5 0 AAA ATPase domain GTP_EFTU PF00009.22 CDI77647.1 - 0.23 10.8 0.0 0.23 10.8 0.0 4.7 4 2 0 4 4 4 0 Elongation factor Tu GTP binding domain DUF3446 PF11928.3 CDI77647.1 - 0.27 11.4 12.1 0.38 10.9 3.7 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) Pkinase PF00069.20 CDI77648.1 - 7.2e-23 81.0 0.0 4.8e-22 78.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI77648.1 - 2.2e-09 36.7 0.0 6.4e-09 35.1 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI77648.1 - 1.9e-08 33.7 0.0 5e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI77648.1 - 0.033 13.9 4.4 0.13 11.9 0.0 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.9 CDI77648.1 - 0.046 12.7 0.0 0.11 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_4 PF12799.2 CDI77649.1 - 2.9e-15 55.4 7.0 3.7e-06 26.4 0.5 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI77649.1 - 4.8e-10 39.0 8.1 6.3e-07 29.0 1.0 3.5 1 1 3 4 4 4 3 Leucine rich repeat LRR_6 PF13516.1 CDI77649.1 - 1.8e-06 27.4 1.9 0.13 12.4 0.1 4.8 4 0 0 4 4 4 1 Leucine Rich repeat LRR_7 PF13504.1 CDI77649.1 - 5.2e-06 25.8 7.4 0.31 11.4 0.1 6.2 6 0 0 6 6 6 1 Leucine rich repeat LRR_9 PF14580.1 CDI77649.1 - 0.00018 21.1 0.2 0.00042 19.9 0.1 1.7 1 1 0 1 1 1 1 Leucine-rich repeat Spt20 PF12090.3 CDI77649.1 - 0.0037 16.6 1.0 0.0056 16.0 0.7 1.3 1 0 0 1 1 1 1 Spt20 family LRR_1 PF00560.28 CDI77649.1 - 0.01 15.7 13.2 0.2 11.8 0.2 5.8 6 1 0 6 6 5 0 Leucine Rich Repeat BAF1_ABF1 PF04684.8 CDI77649.1 - 0.04 12.7 15.2 0.054 12.3 10.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Kin17_mid PF10357.4 CDI77649.1 - 0.11 12.1 6.0 0.17 11.4 4.2 1.3 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein Activator_LAG-3 PF11498.3 CDI77649.1 - 5.8 5.5 31.2 8.1 5.0 21.6 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SHR3_chaperone PF08229.6 CDI77649.1 - 7.1 5.5 6.7 10 5.0 4.6 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Daxx PF03344.10 CDI77651.1 - 0.0049 15.4 12.0 0.0051 15.3 8.3 1.0 1 0 0 1 1 1 1 Daxx Family Ycf1 PF05758.7 CDI77651.1 - 0.23 9.1 5.8 0.22 9.2 4.0 1.0 1 0 0 1 1 1 0 Ycf1 CDC45 PF02724.9 CDI77651.1 - 0.29 9.1 11.4 0.3 9.0 7.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Spore_coat_CotO PF14153.1 CDI77651.1 - 0.36 10.2 16.1 0.44 9.9 11.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF2924 PF11149.3 CDI77651.1 - 0.96 9.4 8.4 1.8 8.5 5.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) Plasmodium_Vir PF05795.6 CDI77651.1 - 2.7 7.1 5.1 3.1 6.8 3.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Neur_chan_memb PF02932.11 CDI77651.1 - 2.9 7.7 4.1 3.7 7.3 2.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GOLD_2 PF13897.1 CDI77651.1 - 5.7 7.1 6.9 8.3 6.6 4.8 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Macoilin PF09726.4 CDI77651.1 - 9.4 4.3 13.5 11 4.1 9.4 1.1 1 0 0 1 1 1 0 Transmembrane protein PP2C PF00481.16 CDI77655.1 - 5e-31 108.0 0.5 3e-22 79.2 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C DUF755 PF05501.6 CDI77655.1 - 0.0001 22.3 23.9 0.00016 21.7 16.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF755) PP2C_2 PF13672.1 CDI77655.1 - 0.0035 16.7 4.0 0.026 13.9 2.8 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C Mem_trans PF03547.13 CDI77655.1 - 0.016 13.4 5.7 0.021 13.1 3.9 1.1 1 0 0 1 1 1 0 Membrane transport protein Na_trans_assoc PF06512.8 CDI77655.1 - 0.032 14.1 6.1 0.042 13.8 4.2 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated DUF2894 PF11445.3 CDI77655.1 - 0.054 13.7 6.8 0.079 13.2 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Ndc1_Nup PF09531.5 CDI77655.1 - 0.055 11.8 6.5 0.068 11.5 4.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ycf1 PF05758.7 CDI77655.1 - 0.055 11.1 5.9 0.066 10.9 4.1 1.0 1 0 0 1 1 1 0 Ycf1 SLD3 PF08639.5 CDI77655.1 - 0.12 10.9 14.9 0.16 10.5 10.3 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 Fmp27_WPPW PF10359.4 CDI77655.1 - 0.14 10.5 10.6 0.19 10.1 7.3 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Hid1 PF12722.2 CDI77655.1 - 0.15 9.6 10.4 0.19 9.3 7.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med15 PF09606.5 CDI77655.1 - 0.19 9.8 21.4 0.24 9.5 14.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ebola_NP PF05505.7 CDI77655.1 - 0.19 9.7 8.8 0.24 9.4 6.1 1.0 1 0 0 1 1 1 0 Ebola nucleoprotein DUF1669 PF07894.7 CDI77655.1 - 0.24 10.5 7.1 0.35 10.0 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1669) Neur_chan_memb PF02932.11 CDI77655.1 - 0.49 10.2 3.7 0.64 9.8 2.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PEX11 PF05648.9 CDI77655.1 - 0.55 9.4 2.5 0.81 8.9 1.7 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF2217 PF10265.4 CDI77655.1 - 0.61 8.7 8.1 0.81 8.3 5.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) FHIPEP PF00771.15 CDI77655.1 - 0.76 8.0 4.1 0.94 7.7 2.9 1.1 1 0 0 1 1 1 0 FHIPEP family MDFI PF15316.1 CDI77655.1 - 0.77 9.7 6.8 1.3 9.0 4.7 1.3 1 0 0 1 1 1 0 MyoD family inhibitor DNA_pol_viral_N PF00242.12 CDI77655.1 - 1 8.2 10.1 1.3 7.9 7.0 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Mcm10 PF09332.6 CDI77655.1 - 1.1 8.5 12.1 1.4 8.1 8.4 1.1 1 0 0 1 1 1 0 Mcm10 replication factor DUF4407 PF14362.1 CDI77655.1 - 1.1 8.1 6.7 1.5 7.6 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.12 CDI77655.1 - 1.7 7.4 3.9 2.2 7.0 2.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4652 PF15525.1 CDI77655.1 - 2.3 7.6 11.1 3.4 7.0 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4652) Allexi_40kDa PF05549.6 CDI77655.1 - 2.9 7.0 7.8 4.3 6.5 5.4 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein BAF1_ABF1 PF04684.8 CDI77655.1 - 3 6.5 15.6 4.2 6.0 10.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM60A PF15396.1 CDI77655.1 - 3.4 7.3 8.9 4.8 6.8 6.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A OmpH PF03938.9 CDI77655.1 - 3.5 7.5 21.9 5.2 6.9 15.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2215 PF10225.4 CDI77655.1 - 3.7 6.9 5.7 5.3 6.4 3.9 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Plasmodium_Vir PF05795.6 CDI77655.1 - 3.9 6.5 8.8 5.1 6.2 6.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Lin-8 PF03353.10 CDI77655.1 - 4.2 6.5 13.0 5.7 6.1 9.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4175 PF13779.1 CDI77655.1 - 5.1 4.6 21.8 6.4 4.3 15.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2146 PF10220.4 CDI77655.1 - 5.6 4.8 10.7 7 4.4 7.4 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) SWIB PF02201.13 CDI77656.1 - 1.4e-11 43.8 0.0 2.4e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain Ycf1 PF05758.7 CDI77656.1 - 0.071 10.8 9.5 0.16 9.6 6.6 1.6 1 0 0 1 1 1 0 Ycf1 LMBR1 PF04791.11 CDI77656.1 - 0.53 8.8 1.3 1.5 7.3 0.9 1.9 1 0 0 1 1 1 0 LMBR1-like membrane protein Pol_alpha_B_N PF08418.5 CDI77657.1 - 2.6 7.5 11.1 5.2 6.5 7.7 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal ORC6 PF05460.8 CDI77657.1 - 5 6.1 9.9 6.7 5.7 6.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Striatin PF08232.7 CDI77657.1 - 5.9 7.1 6.4 83 3.4 4.7 2.0 2 0 0 2 2 2 0 Striatin family Tmemb_cc2 PF10267.4 CDI77657.1 - 6.7 5.1 7.1 10 4.5 5.0 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Macoilin PF09726.4 CDI77660.1 - 0.0012 17.2 17.5 0.002 16.5 12.1 1.2 1 0 0 1 1 1 1 Transmembrane protein Raftlin PF15250.1 CDI77660.1 - 0.073 11.5 9.3 0.1 11.1 6.4 1.1 1 0 0 1 1 1 0 Raftlin Zip PF02535.17 CDI77660.1 - 0.15 11.0 14.9 0.25 10.3 10.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Otopetrin PF03189.8 CDI77660.1 - 0.17 10.8 0.3 0.19 10.6 0.2 1.1 1 0 0 1 1 1 0 Otopetrin Melibiase PF02065.13 CDI77660.1 - 0.18 10.4 6.8 0.25 10.0 4.7 1.1 1 0 0 1 1 1 0 Melibiase EPL1 PF10513.4 CDI77660.1 - 0.19 11.9 10.9 0.28 11.4 6.6 1.9 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF4557 PF15101.1 CDI77660.1 - 0.25 11.1 13.2 0.45 10.3 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Hid1 PF12722.2 CDI77660.1 - 1.2 6.7 12.5 1.7 6.2 8.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SelP_N PF04592.9 CDI77660.1 - 1.5 8.1 23.2 3 7.1 16.1 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FLO_LFY PF01698.11 CDI77660.1 - 2.3 6.9 14.7 3.4 6.4 10.2 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Ribosomal_S8e PF01201.17 CDI77661.1 - 2e-50 170.3 0.4 2.3e-50 170.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e AAA_28 PF13521.1 CDI77662.1 - 0.15 11.9 0.8 0.22 11.4 0.5 1.2 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.1 CDI77662.1 - 0.2 10.6 2.3 0.26 10.2 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med3 PF11593.3 CDI77662.1 - 0.62 9.2 6.6 1 8.5 4.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SR-25 PF10500.4 CDI77662.1 - 2.2 7.7 10.7 1.7 8.0 1.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-DHHC PF01529.15 CDI77662.1 - 3.5 6.9 5.9 3.5 6.9 4.1 1.3 1 1 0 1 1 1 0 DHHC palmitoyltransferase APC_CDC26 PF10471.4 CDI77662.1 - 5.8 7.7 15.5 15 6.3 8.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 BUD22 PF09073.5 CDI77664.1 - 0.0085 15.2 8.7 0.01 14.9 6.0 1.1 1 0 0 1 1 1 1 BUD22 DUF2721 PF11026.3 CDI77664.1 - 0.043 13.4 0.0 0.074 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Ribosomal_60s PF00428.14 CDI77664.1 - 0.046 14.1 18.2 0.046 14.1 12.6 3.1 2 1 1 3 3 2 0 60s Acidic ribosomal protein Sigma70_ner PF04546.8 CDI77664.1 - 0.1 12.2 5.4 0.14 11.7 3.8 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region SR-25 PF10500.4 CDI77664.1 - 0.24 10.8 17.1 0.045 13.2 9.3 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.3 CDI77664.1 - 0.26 11.4 12.6 0.66 10.1 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) DUF2217 PF10265.4 CDI77664.1 - 0.28 9.8 5.2 0.3 9.8 3.6 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF3123 PF11321.3 CDI77664.1 - 0.43 10.8 11.3 0.044 14.0 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) DUF572 PF04502.8 CDI77664.1 - 0.51 9.4 9.5 0.32 10.1 5.4 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF572) DUF1635 PF07795.6 CDI77664.1 - 0.68 9.2 5.3 0.88 8.9 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) TFIIF_alpha PF05793.7 CDI77664.1 - 0.69 8.2 7.7 0.76 8.0 5.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF755 PF05501.6 CDI77664.1 - 0.76 9.8 14.0 1.1 9.3 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Cobl PF09469.5 CDI77664.1 - 1.3 9.0 4.6 0.9 9.5 2.0 1.6 1 1 0 1 1 1 0 Cordon-bleu ubiquitin-like domain CDK2AP PF09806.4 CDI77664.1 - 8.1 6.6 18.4 0.51 10.5 5.5 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein DNA_pol_A_exo1 PF01612.15 CDI77666.1 - 5.5e-09 35.7 0.0 9.2e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease NdhL PF10716.4 CDI77667.1 - 0.0079 15.9 1.4 0.014 15.1 1.0 1.3 1 0 0 1 1 1 1 NADH dehydrogenase transmembrane subunit PrpF PF04303.8 CDI77667.1 - 0.059 12.0 0.7 0.084 11.6 0.5 1.1 1 0 0 1 1 1 0 PrpF protein DEC-1_N PF04625.8 CDI77667.1 - 0.63 8.6 8.7 0.87 8.1 6.1 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Peptidase_M17 PF00883.16 CDI77668.1 - 5e-114 380.3 3.2 5e-114 380.3 2.3 2.7 2 1 0 2 2 2 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.12 CDI77668.1 - 1e-08 34.9 0.0 1e-08 34.9 0.0 4.8 3 2 0 3 3 3 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_C48 PF02902.14 CDI77669.1 - 1.4e-27 96.7 0.0 4.2e-27 95.1 0.0 1.8 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Creb_binding PF09030.5 CDI77670.1 - 0.015 15.4 0.6 0.076 13.2 0.4 2.3 1 0 0 1 1 1 0 Creb binding DUF86 PF01934.12 CDI77670.1 - 0.059 13.0 0.1 0.19 11.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF86 GDA1_CD39 PF01150.12 CDI77673.1 - 1.9e-30 105.7 0.2 1.1e-29 103.1 0.1 2.1 2 1 0 2 2 2 1 GDA1/CD39 (nucleoside phosphatase) family TCTP PF00838.12 CDI77673.1 - 0.0051 16.8 0.6 0.025 14.5 0.0 2.1 2 1 0 2 2 2 1 Translationally controlled tumour protein EamA PF00892.15 CDI77673.1 - 0.13 12.2 0.0 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 EamA-like transporter family Tir_receptor_C PF07489.6 CDI77674.1 - 0.0012 18.6 2.9 0.0021 17.8 2.0 1.3 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) C-terminus SR-25 PF10500.4 CDI77674.1 - 0.56 9.6 10.8 0.95 8.8 7.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SoxE PF06525.6 CDI77674.1 - 0.82 8.9 3.9 1.4 8.1 2.7 1.4 1 0 0 1 1 1 0 Sulfocyanin (SoxE) DUF1908 PF08926.6 CDI77674.1 - 5.2 5.7 12.0 2.7 6.6 5.9 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1908) Mlo PF03094.10 CDI77675.1 - 0.098 10.7 4.1 0.12 10.5 2.8 1.0 1 0 0 1 1 1 0 Mlo family RAB3GAP2_N PF14655.1 CDI77675.1 - 0.25 10.2 6.2 0.23 10.4 4.3 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4638 PF15472.1 CDI77675.1 - 0.33 10.5 4.7 0.3 10.6 3.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4638) Suf PF05843.9 CDI77675.1 - 1.2 8.8 11.0 1.2 8.8 7.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MraZ PF02381.13 CDI77675.1 - 1.6 8.5 4.9 2.2 8.0 3.4 1.3 1 0 0 1 1 1 0 MraZ protein Med15 PF09606.5 CDI77675.1 - 2.8 6.0 25.0 2.9 5.9 17.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI77675.1 - 8.5 5.0 26.7 8.2 5.0 18.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ABC_ATPase PF09818.4 CDI77676.1 - 5.3e-178 592.2 0.0 6.9e-178 591.8 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.1 CDI77676.1 - 0.0025 18.1 0.0 0.0035 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CDI77676.1 - 0.037 13.4 0.0 0.071 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CDI77676.1 - 0.12 11.9 0.0 0.31 10.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Exo_endo_phos PF03372.18 CDI77677.1 - 8.1e-15 55.4 0.0 1.2e-14 54.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TFIIS_C PF01096.13 CDI77677.1 - 5.3e-06 25.9 3.1 2e-05 24.1 0.1 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DNA_RNApol_7kD PF03604.8 CDI77677.1 - 2.4 7.6 7.8 0.98 8.9 0.1 3.4 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_2 PF13240.1 CDI77677.1 - 4.1 7.0 7.0 11 5.7 0.0 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Kelch_3 PF13415.1 CDI77678.1 - 2.6e-29 100.6 10.9 4.7e-12 45.7 0.5 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.1 CDI77678.1 - 3e-25 87.7 13.3 5.5e-07 29.2 0.0 4.6 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI77678.1 - 5e-23 80.6 2.9 3.3e-05 23.7 0.0 4.8 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 CDI77678.1 - 7.7e-16 57.5 14.3 3.2e-06 27.0 0.5 5.1 3 1 2 5 5 5 4 Kelch motif Kelch_2 PF07646.10 CDI77678.1 - 6.3e-14 51.1 16.5 0.00079 19.1 1.3 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.20 CDI77678.1 - 3.1e-12 45.8 9.7 0.003 17.0 0.2 5.7 5 1 0 5 5 5 4 Kelch motif Prefoldin_2 PF01920.15 CDI77678.1 - 0.045 13.5 0.1 0.089 12.5 0.1 1.4 1 0 0 1 1 1 0 Prefoldin subunit Cep57_CLD_2 PF14197.1 CDI77678.1 - 0.33 10.9 1.8 4.7 7.2 0.2 2.5 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 adh_short PF00106.20 CDI77679.1 - 1.3e-06 28.3 0.0 4.7e-06 26.6 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDI77679.1 - 0.00027 20.6 0.1 0.0019 17.8 0.0 2.0 2 0 0 2 2 2 1 KR domain ORC2 PF04084.9 CDI77680.1 - 2.4e-22 79.2 0.0 3.4e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 SR-25 PF10500.4 CDI77680.1 - 1.6 8.1 15.4 0.3 10.5 7.1 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Gly-zipper_Omp PF13488.1 CDI77681.1 - 0.019 14.6 9.7 0.019 14.6 6.7 4.0 3 1 1 4 4 4 0 Glycine zipper TMA7 PF09072.5 CDI77682.1 - 7.8e-10 39.0 16.6 1.2e-09 38.4 11.5 1.3 1 0 0 1 1 1 1 Translation machinery associated TMA7 C2 PF00168.25 CDI77683.1 - 8.1e-20 70.4 0.0 4e-07 29.7 0.0 4.9 4 0 0 4 4 4 4 C2 domain SF3b1 PF08920.5 CDI77684.1 - 5.7e-32 110.7 4.7 1.8e-27 96.1 0.0 3.4 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.1 CDI77684.1 - 1.7e-11 44.2 10.8 0.0098 16.1 0.0 7.5 7 2 1 8 8 8 3 HEAT repeats HEAT_EZ PF13513.1 CDI77684.1 - 9.8e-08 32.2 4.0 0.21 12.1 0.0 7.5 8 2 2 10 10 10 2 HEAT-like repeat HEAT PF02985.17 CDI77684.1 - 8.2e-07 28.5 13.9 1.6 9.0 0.1 8.5 9 0 0 9 9 8 2 HEAT repeat Adaptin_N PF01602.15 CDI77684.1 - 4.3e-05 22.0 0.5 0.089 11.0 0.0 3.8 3 1 1 4 4 4 1 Adaptin N terminal region UME PF08064.8 CDI77684.1 - 0.00089 19.1 0.7 0.65 9.9 0.0 3.9 4 0 0 4 4 4 1 UME (NUC010) domain Arm PF00514.18 CDI77684.1 - 0.0028 17.4 5.3 6.7 6.6 0.0 5.1 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat DUF2435 PF10363.4 CDI77684.1 - 0.05 13.4 3.4 5.5 6.9 0.2 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2435) CLASP_N PF12348.3 CDI77684.1 - 0.052 12.8 0.0 1.5 8.0 0.0 2.6 2 0 0 2 2 2 0 CLASP N terminal Cnd3 PF12719.2 CDI77684.1 - 0.074 12.0 0.8 0.78 8.6 0.0 2.7 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain Hamartin PF04388.7 CDI77684.1 - 1.8 7.1 3.6 1.2 7.7 0.1 2.0 2 0 0 2 2 2 0 Hamartin protein Myb_DNA-binding PF00249.26 CDI77685.1 - 0.0015 18.5 8.9 0.44 10.6 0.1 4.4 5 0 0 5 5 5 2 Myb-like DNA-binding domain Daxx PF03344.10 CDI77686.1 - 0.069 11.6 5.6 0.076 11.5 3.9 1.2 1 0 0 1 1 1 0 Daxx Family Med3 PF11593.3 CDI77686.1 - 0.34 10.1 8.0 0.4 9.8 5.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CDC45 PF02724.9 CDI77686.1 - 0.67 7.9 5.7 0.79 7.6 4.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Orbi_VP6 PF01516.11 CDI77686.1 - 1 8.3 10.2 1.5 7.8 7.1 1.2 1 0 0 1 1 1 0 Orbivirus helicase VP6 Menin PF05053.8 CDI77686.1 - 8.9 4.3 9.2 14 3.7 6.4 1.3 1 0 0 1 1 1 0 Menin Apt1 PF10351.4 CDI77687.1 - 1.8 7.3 21.8 2.5 6.8 15.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain GEMIN8 PF15348.1 CDI77687.1 - 1.8 8.5 6.5 2.9 7.8 4.5 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Macoilin PF09726.4 CDI77687.1 - 3 5.9 30.0 5.3 5.1 20.8 1.3 1 0 0 1 1 1 0 Transmembrane protein DUF572 PF04502.8 CDI77687.1 - 4.7 6.3 12.2 8.2 5.5 8.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) LMBR1 PF04791.11 CDI77688.1 - 3.6 6.0 12.2 8.7 4.8 8.4 1.7 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIA PF03153.8 CDI77689.1 - 2.6 7.8 18.6 3.6 7.4 12.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit E_Pc_C PF06752.7 CDI77690.1 - 0.033 13.7 6.1 0.046 13.2 4.2 1.2 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus FUSC PF04632.7 CDI77690.1 - 2.1 6.6 5.2 2.5 6.4 3.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Herpes_capsid PF06112.6 CDI77690.1 - 4.7 7.2 8.3 7.8 6.5 5.8 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein TRAPP PF04051.11 CDI77691.1 - 5.1e-14 52.0 0.0 1.4e-12 47.3 0.0 2.1 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4614 PF15391.1 CDI77691.1 - 0.18 11.5 13.5 0.23 11.2 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CDC45 PF02724.9 CDI77691.1 - 0.44 8.5 6.0 0.47 8.4 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF566 PF04484.7 CDI77691.1 - 0.76 9.2 13.9 0.8 9.1 9.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) DNA_pol_viral_N PF00242.12 CDI77691.1 - 0.94 8.4 14.1 1.1 8.1 9.7 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Period_C PF12114.3 CDI77691.1 - 1.3 8.5 21.5 1.7 8.2 14.9 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region FRG2 PF15315.1 CDI77691.1 - 1.7 8.6 16.6 2.2 8.2 11.5 1.4 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 DUF2201_N PF13203.1 CDI77691.1 - 1.7 7.7 5.7 2.3 7.2 4.0 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF4349 PF14257.1 CDI77691.1 - 1.8 7.7 5.0 2.2 7.4 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Sec3_C PF09763.4 CDI77691.1 - 2.3 6.2 8.6 2.7 6.0 5.9 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF3827 PF12877.2 CDI77691.1 - 3 5.8 12.8 3.3 5.6 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Macoilin PF09726.4 CDI77691.1 - 4 5.6 20.7 4.5 5.4 14.3 1.0 1 0 0 1 1 1 0 Transmembrane protein Peptidase_S64 PF08192.6 CDI77691.1 - 6 5.0 10.9 6.9 4.8 7.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.4 CDI77691.1 - 7.7 5.2 17.9 9.8 4.9 12.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.4 CDI77692.1 - 5.1e-05 21.9 31.9 6.9e-05 21.5 22.1 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 RRM_6 PF14259.1 CDI77692.1 - 8.3e-05 22.4 0.0 0.054 13.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Ebola_NP PF05505.7 CDI77692.1 - 0.0074 14.4 27.5 0.0098 14.0 19.0 1.1 1 0 0 1 1 1 1 Ebola nucleoprotein TFIIF_alpha PF05793.7 CDI77692.1 - 0.026 12.9 38.7 0.035 12.4 26.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Daxx PF03344.10 CDI77692.1 - 0.028 12.9 29.2 0.037 12.5 20.2 1.1 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 CDI77692.1 - 0.25 10.6 29.2 0.36 10.0 20.2 1.3 1 0 0 1 1 1 0 SDA1 PLRV_ORF5 PF01690.12 CDI77692.1 - 1.7 7.7 30.5 2.3 7.2 21.1 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF572 PF04502.8 CDI77692.1 - 2.1 7.4 38.0 3.3 6.8 26.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) LMBR1 PF04791.11 CDI77692.1 - 2.6 6.5 8.4 3.2 6.2 5.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AvrE PF11725.3 CDI77692.1 - 5.6 3.8 24.5 6 3.7 17.0 1.2 1 0 0 1 1 1 0 Pathogenicity factor Asp-B-Hydro_N PF05279.6 CDI77692.1 - 6.9 6.4 23.8 10 5.8 16.5 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SPRY PF00622.23 CDI77694.1 - 0.0012 18.9 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 SPRY domain EMP24_GP25L PF01105.19 CDI77695.1 - 1.4e-30 106.3 0.0 1.8e-30 106.0 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4199 PF13858.1 CDI77695.1 - 0.065 13.1 0.5 0.11 12.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Vma12 PF11712.3 CDI77695.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase EzrA PF06160.7 CDI77698.1 - 0.0065 14.7 1.4 0.012 13.8 1.0 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA SR-25 PF10500.4 CDI77699.1 - 7.7e-05 22.2 4.9 7.7e-05 22.2 3.4 3.7 3 1 0 3 3 3 1 Nuclear RNA-splicing-associated protein MMS1_N PF10433.4 CDI77699.1 - 0.033 12.3 0.5 0.052 11.6 0.3 1.2 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term 7tm_7 PF08395.7 CDI77699.1 - 0.42 9.5 0.0 0.42 9.5 0.0 2.3 2 1 1 3 3 3 0 7tm Chemosensory receptor DEAD PF00270.24 CDI77700.1 - 1e-30 106.4 0.0 1e-29 103.1 0.0 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI77700.1 - 1.1e-21 76.4 0.3 4.9e-21 74.3 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI77700.1 - 0.014 15.2 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Hist_deacetyl PF00850.14 CDI77701.1 - 1.3e-71 241.4 0.0 4.3e-71 239.7 0.0 1.8 1 1 0 1 1 1 1 Histone deacetylase domain DnaJ PF00226.26 CDI77702.1 - 5.1e-27 93.3 1.1 9.1e-27 92.5 0.8 1.4 1 0 0 1 1 1 1 DnaJ domain Thiolase_N PF00108.18 CDI77704.1 - 5.1e-73 245.2 0.2 8.8e-73 244.5 0.0 1.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CDI77704.1 - 4.6e-50 168.1 0.3 4.6e-50 168.1 0.2 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 CDI77704.1 - 2.3e-06 27.2 1.5 6e-06 25.9 1.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.5 CDI77704.1 - 0.018 15.0 0.0 0.049 13.6 0.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DnaJ PF00226.26 CDI77709.1 - 0.00025 20.7 0.2 0.0007 19.2 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain DcuC PF03606.10 CDI77709.1 - 0.00087 17.6 0.6 0.0018 16.5 0.4 1.5 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier XK-related PF09815.4 CDI77709.1 - 0.2 10.6 0.1 0.63 8.9 0.0 1.8 1 0 0 1 1 1 0 XK-related protein UBA_e1_C PF09358.5 CDI77710.1 - 0.0034 17.5 11.4 1.1 9.3 0.1 4.4 4 0 0 4 4 4 2 Ubiquitin-activating enzyme e1 C-terminal domain DUF3446 PF11928.3 CDI77710.1 - 0.51 10.5 18.7 3.1 8.0 6.7 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) DUF4539 PF15072.1 CDI77711.1 - 2.4e-07 30.3 0.2 1.1e-06 28.1 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4539) Rib_5-P_isom_A PF06026.9 CDI77712.1 - 3.1e-44 150.3 0.0 2.4e-21 75.8 0.0 4.1 1 1 1 2 2 2 2 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) NHL PF01436.16 CDI77712.1 - 0.00071 19.4 0.5 6.7 6.8 0.0 3.6 3 0 0 3 3 3 2 NHL repeat Amidohydro_2 PF04909.9 CDI77712.1 - 0.024 14.1 0.3 6.2 6.2 0.0 2.1 1 1 1 2 2 2 0 Amidohydrolase RPAP3_C PF13877.1 CDI77713.1 - 8.3e-07 28.8 0.0 2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 DUF4614 PF15391.1 CDI77713.1 - 2.2 8.0 24.5 3.2 7.5 7.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Period_C PF12114.3 CDI77713.1 - 5.1 6.6 34.0 1.4 8.5 3.4 2.7 2 0 0 2 2 2 0 Period protein 2/3C-terminal region CAF-1_p150 PF11600.3 CDI77713.1 - 5.4 6.3 25.6 3.5 6.9 7.8 2.4 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Pex14_N PF04695.8 CDI77713.1 - 6.4 6.8 19.0 0.8 9.7 1.0 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region tRNA-synt_2 PF00152.15 CDI77715.1 - 6.3e-40 136.9 4.0 1.4e-26 93.0 0.0 3.6 2 1 1 3 3 3 2 tRNA synthetases class II (D, K and N) Med15 PF09606.5 CDI77715.1 - 0.0007 17.9 18.8 0.0007 17.9 13.1 3.0 3 1 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal FimP PF09766.4 CDI77715.1 - 0.011 14.8 19.4 0.013 14.5 6.8 2.4 2 0 0 2 2 2 0 Fms-interacting protein AAA_23 PF13476.1 CDI77715.1 - 0.07 13.4 10.4 0.026 14.8 0.6 2.3 2 0 0 2 2 2 0 AAA domain DUF4557 PF15101.1 CDI77715.1 - 4.6 7.0 28.4 9.2 6.0 1.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Aminotran_5 PF00266.14 CDI77716.1 - 5.7e-53 179.9 1.8 8.5e-20 70.8 0.1 3.3 1 1 2 3 3 3 3 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CDI77716.1 - 3.5e-05 23.0 0.1 3.5e-05 23.0 0.1 2.9 2 1 1 3 3 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family PAT1 PF09770.4 CDI77716.1 - 0.00027 19.3 21.5 0.00027 19.3 14.9 2.1 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 Pyridoxal_deC PF00282.14 CDI77716.1 - 0.00057 18.4 0.1 0.0012 17.4 0.1 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Pex14_N PF04695.8 CDI77716.1 - 0.005 16.8 9.9 0.005 16.8 6.8 2.4 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.8 CDI77716.1 - 0.021 14.3 10.0 3.1 7.2 6.8 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain AUX_IAA PF02309.11 CDI77716.1 - 0.12 12.1 10.7 0.029 14.1 4.2 2.0 2 0 0 2 2 2 0 AUX/IAA family Dicty_REP PF05086.7 CDI77716.1 - 0.27 8.9 2.4 0.36 8.5 1.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Spore_coat_CotO PF14153.1 CDI77716.1 - 1.3 8.4 21.9 0.048 13.1 8.5 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Radial_spoke_3 PF06098.6 CDI77716.1 - 1.8 7.4 26.1 0.016 14.2 10.3 2.1 2 0 0 2 2 2 0 Radial spoke protein 3 FAM60A PF15396.1 CDI77716.1 - 3.1 7.4 13.2 2.1 8.0 5.9 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Suf PF05843.9 CDI77716.1 - 4.6 6.8 21.0 0.47 10.1 8.4 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DDHD PF02862.12 CDI77716.1 - 7.9 6.1 13.9 15 5.3 7.8 2.1 2 0 0 2 2 2 0 DDHD domain Ribosomal_60s PF00428.14 CDI77717.1 - 0.92 9.9 14.5 4.2 7.8 0.8 3.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein Ribosomal_60s PF00428.14 CDI77718.1 - 0.84 10.0 10.3 1.1 9.6 7.2 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein OMP_b-brl PF13505.1 CDI77718.1 - 1.6 8.6 6.9 1.8 8.4 4.8 1.1 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain DUF1510 PF07423.6 CDI77721.1 - 0.009 15.3 9.7 0.009 15.3 6.7 3.4 4 1 0 4 4 4 2 Protein of unknown function (DUF1510) DUF1546 PF07571.8 CDI77723.1 - 2e-06 27.8 0.1 2e-06 27.8 0.1 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1546) SOBP PF15279.1 CDI77723.1 - 2.1 8.6 34.3 3.5 7.9 2.0 3.2 3 0 0 3 3 3 0 Sine oculis-binding protein SID-1_RNA_chan PF13965.1 CDI77723.1 - 3.9 5.5 3.8 7.9 4.5 2.6 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4063 PF13272.1 CDI77724.1 - 0.15 11.8 0.1 0.15 11.8 0.1 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF4063) MSP1_C PF07462.6 CDI77724.1 - 2.2 6.5 10.4 3.2 6.0 7.2 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus PBP1_TM PF14812.1 CDI77724.1 - 3.1 8.1 8.5 28 5.0 4.5 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CD20 PF04103.10 CDI77725.1 - 0.029 14.2 16.2 0.15 12.0 0.0 4.8 4 1 0 4 4 4 0 CD20-like family DUF3458 PF11940.3 CDI77726.1 - 5e-26 91.4 0.1 7.1e-26 90.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Peptidase_M1 PF01433.15 CDI77727.1 - 6e-15 55.2 14.0 1.2e-06 27.9 0.0 3.2 2 1 1 3 3 3 2 Peptidase family M1 Hom_end_hint PF05203.11 CDI77727.1 - 0.00051 19.8 4.6 0.00083 19.1 3.2 1.4 1 0 0 1 1 1 1 Hom_end-associated Hint CRT10 PF08728.5 CDI77727.1 - 0.00091 17.3 7.4 0.0012 16.9 5.2 1.2 1 0 0 1 1 1 1 CRT10 HlyD_2 PF12700.2 CDI77727.1 - 0.0013 17.9 16.6 0.0018 17.5 11.5 1.3 1 0 0 1 1 1 1 HlyD family secretion protein MIP-T3 PF10243.4 CDI77727.1 - 0.0014 17.1 31.3 0.0014 17.1 21.7 1.9 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 PAT1 PF09770.4 CDI77727.1 - 0.003 15.8 51.2 0.0045 15.3 35.5 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DDHD PF02862.12 CDI77727.1 - 0.0094 15.7 17.4 0.0094 15.7 12.1 2.4 2 0 0 2 2 2 1 DDHD domain CDC45 PF02724.9 CDI77727.1 - 0.016 13.2 21.2 0.025 12.6 14.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 CDI77727.1 - 0.032 11.9 23.3 0.043 11.5 16.1 1.1 1 0 0 1 1 1 0 Ycf1 LMBR1 PF04791.11 CDI77727.1 - 0.048 12.2 6.2 0.062 11.8 4.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2201_N PF13203.1 CDI77727.1 - 0.06 12.5 23.8 0.11 11.6 16.5 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain SET PF00856.23 CDI77727.1 - 0.14 12.4 2.7 0.34 11.1 1.9 1.7 1 0 0 1 1 1 0 SET domain SAPS PF04499.10 CDI77727.1 - 0.16 10.6 20.8 0.27 9.8 14.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1510 PF07423.6 CDI77727.1 - 0.28 10.5 34.6 0.47 9.8 24.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SOBP PF15279.1 CDI77727.1 - 0.47 10.7 40.8 0.13 12.6 14.8 2.4 2 0 0 2 2 2 0 Sine oculis-binding protein Membralin PF09746.4 CDI77727.1 - 0.57 9.1 10.8 1.1 8.2 7.5 1.4 1 0 0 1 1 1 0 Tumour-associated protein GPCR_chapero_1 PF11904.3 CDI77727.1 - 0.65 9.0 22.2 0.023 13.8 11.2 1.6 2 0 0 2 2 2 0 GPCR-chaperone Tim54 PF11711.3 CDI77727.1 - 0.69 8.4 16.5 1.2 7.6 11.4 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 LicD PF04991.8 CDI77727.1 - 0.7 9.9 5.7 1.2 9.2 4.0 1.4 1 0 0 1 1 1 0 LicD family Neur_chan_memb PF02932.11 CDI77727.1 - 0.8 9.5 23.0 0.64 9.8 13.8 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.17 CDI77727.1 - 1.9 7.4 11.9 0.35 9.8 5.5 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Herpes_env PF01673.13 CDI77727.1 - 2.9 6.3 17.7 4.5 5.7 12.3 1.2 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein FLO_LFY PF01698.11 CDI77727.1 - 3.1 6.5 27.0 4.9 5.8 18.7 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein GAGA_bind PF06217.7 CDI77727.1 - 5.1 6.9 30.3 10 5.9 21.0 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family PCEMA1 PF07418.6 CDI77727.1 - 5.7 6.2 16.1 8.5 5.6 11.2 1.2 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 NARP1 PF12569.3 CDI77727.1 - 6.9 5.2 31.4 14 4.2 21.7 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF3435 PF11917.3 CDI77727.1 - 9.5 4.8 31.2 14 4.2 21.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DUF605 PF04652.11 CDI77727.1 - 9.7 5.4 45.3 0.32 10.3 17.8 2.4 2 0 0 2 2 2 0 Vta1 like Peptidase_M16_C PF05193.16 CDI77730.1 - 9.3e-12 44.9 10.5 2.4e-09 37.1 0.0 3.8 3 1 0 3 3 3 2 Peptidase M16 inactive domain CT47 PF15623.1 CDI77730.1 - 0.93 9.1 30.3 0.9 9.2 6.6 2.6 2 0 0 2 2 2 0 Cancer/testis gene family 47 SSP160 PF06933.6 CDI77730.1 - 2.8 5.8 13.7 4.6 5.1 9.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Zip PF02535.17 CDI77731.1 - 0.69 8.8 22.3 0.15 11.0 9.7 3.1 2 1 0 2 2 2 0 ZIP Zinc transporter RAP PF08373.5 CDI77733.1 - 0.018 14.8 0.2 0.06 13.1 0.0 2.0 2 0 0 2 2 2 0 RAP domain F-protein PF00469.15 CDI77733.1 - 8.2 5.7 10.4 1.2 8.4 3.0 2.4 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef SNF2_N PF00176.18 CDI77734.1 - 2.2e-73 246.6 1.2 1.9e-69 233.7 0.0 3.8 3 1 1 4 4 4 2 SNF2 family N-terminal domain Helicase_C PF00271.26 CDI77734.1 - 7.5e-16 57.7 0.1 6.9e-15 54.6 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SR-25 PF10500.4 CDI77736.1 - 6.2e-05 22.5 19.6 7.3e-05 22.3 13.6 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF3801 PF12687.2 CDI77736.1 - 0.076 12.5 5.8 0.088 12.3 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) DUF4614 PF15391.1 CDI77736.1 - 0.28 10.9 11.0 0.31 10.7 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PsbW PF07123.7 CDI77736.1 - 0.48 10.4 9.2 0.58 10.2 6.4 1.1 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) DUF3633 PF12315.3 CDI77736.1 - 0.7 9.1 3.6 0.85 8.8 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) DUF515 PF04415.7 CDI77736.1 - 1.4 7.0 10.2 1.3 7.1 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) RR_TM4-6 PF06459.7 CDI77736.1 - 1.6 8.5 11.3 1.9 8.3 7.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CAF-1_p150 PF11600.3 CDI77736.1 - 2.1 7.6 16.2 2.6 7.3 11.3 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Macoilin PF09726.4 CDI77736.1 - 2.2 6.4 13.2 2.3 6.3 9.2 1.0 1 0 0 1 1 1 0 Transmembrane protein Senescence_reg PF04520.8 CDI77736.1 - 3.4 8.1 9.2 4.2 7.8 6.4 1.2 1 0 0 1 1 1 0 Senescence regulator Apt1 PF10351.4 CDI77736.1 - 3.5 6.3 9.0 4 6.2 6.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.6 CDI77736.1 - 8.2 4.3 8.5 7.9 4.4 5.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hid1 PF12722.2 CDI77736.1 - 8.2 3.9 11.1 8.6 3.8 7.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRM_1 PF00076.17 CDI77739.1 - 1.4e-15 56.6 0.0 2e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI77739.1 - 7.2e-13 48.3 0.0 1e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI77739.1 - 1.1e-08 34.7 0.0 1.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Str_synth PF03088.11 CDI77740.1 - 8.1e-08 32.1 0.0 1.5e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Strictosidine synthase SGL PF08450.7 CDI77740.1 - 4.5e-05 22.9 0.0 0.00021 20.7 0.0 1.9 2 0 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region AAA_23 PF13476.1 CDI77740.1 - 0.011 16.0 13.2 0.015 15.6 9.2 1.2 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 CDI77740.1 - 7 4.9 10.9 9.5 4.5 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Methyltransf_11 PF08241.7 CDI77742.1 - 3.1e-19 69.2 0.0 3.2e-18 66.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI77742.1 - 3.1e-17 62.7 0.0 6.6e-17 61.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI77742.1 - 3.9e-16 59.0 0.0 6.5e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI77742.1 - 1.1e-15 58.1 0.1 3.2e-15 56.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI77742.1 - 1.1e-14 54.5 0.0 1.2e-13 51.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 CDI77742.1 - 2.2e-12 46.6 0.0 3.3e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 CDI77742.1 - 1e-11 44.4 0.0 5.9e-09 35.3 0.0 2.3 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 CDI77742.1 - 6e-11 42.6 0.1 2.1e-10 40.9 0.0 2.0 3 0 0 3 3 2 1 Methyltransferase domain MTS PF05175.9 CDI77742.1 - 1.6e-08 34.1 0.0 3.3e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 CDI77742.1 - 5.8e-08 32.7 0.0 1.4e-07 31.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CDI77742.1 - 0.00032 20.2 0.0 0.0012 18.3 0.0 1.9 3 0 0 3 3 3 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 CDI77742.1 - 0.00053 19.2 0.0 0.0011 18.1 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_PK PF05891.7 CDI77742.1 - 0.00092 18.5 0.0 0.021 14.1 0.0 2.0 1 1 1 2 2 2 2 AdoMet dependent proline di-methyltransferase CheR PF01739.13 CDI77742.1 - 0.00095 18.4 0.0 0.034 13.4 0.0 2.2 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.14 CDI77742.1 - 0.0013 18.7 0.0 0.0036 17.3 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase RrnaAD PF00398.15 CDI77742.1 - 0.0024 16.9 0.0 0.0059 15.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.12 CDI77742.1 - 0.0074 15.3 0.0 0.024 13.6 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_9 PF08003.6 CDI77742.1 - 0.0098 14.6 0.0 0.017 13.8 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) DOT1 PF08123.8 CDI77742.1 - 0.023 14.0 0.0 0.047 12.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 NodS PF05401.6 CDI77742.1 - 0.029 13.7 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) PrmA PF06325.8 CDI77742.1 - 0.076 12.1 1.2 0.097 11.7 0.1 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.1 CDI77742.1 - 0.099 12.3 0.0 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain F5_F8_type_C PF00754.20 CDI77743.1 - 2.4e-06 27.4 0.0 0.0087 15.8 0.0 3.1 2 1 0 2 2 2 2 F5/8 type C domain LCCL PF03815.14 CDI77744.1 - 4.9e-13 48.8 0.1 7.9e-13 48.2 0.1 1.3 1 0 0 1 1 1 1 LCCL domain LZ_Tnp_IS66 PF13007.2 CDI77744.1 - 0.019 15.6 4.1 0.067 13.8 0.2 2.1 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Plasmid_stab_B PF10784.4 CDI77744.1 - 0.055 13.0 0.3 0.12 12.0 0.2 1.5 1 0 0 1 1 1 0 Plasmid stability protein Rxt3 PF08642.5 CDI77744.1 - 0.14 12.3 0.0 0.3 11.3 0.0 1.7 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Ribosomal_60s PF00428.14 CDI77744.1 - 0.44 10.9 11.2 2.3 8.6 2.4 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein CDC45 PF02724.9 CDI77745.1 - 0.091 10.7 22.4 0.1 10.6 15.5 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.8 CDI77745.1 - 0.84 9.4 34.9 1.1 9.0 24.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI77745.1 - 1.1 7.3 41.5 1.3 7.1 28.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dsh_C PF12316.3 CDI77745.1 - 3.8 7.5 13.3 5 7.1 9.2 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Asp-B-Hydro_N PF05279.6 CDI77745.1 - 6.4 6.5 40.7 8.2 6.1 28.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Borrelia_P83 PF05262.6 CDI77745.1 - 6.5 4.9 34.8 7.2 4.7 24.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein AvrE PF11725.3 CDI77745.1 - 7.3 3.4 25.4 7.6 3.4 17.6 1.0 1 0 0 1 1 1 0 Pathogenicity factor ACOX PF01756.14 CDI77746.1 - 3.7e-34 117.7 0.6 6.3e-34 116.9 0.1 1.5 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.19 CDI77746.1 - 0.0036 17.4 1.2 0.42 10.7 0.0 2.9 2 1 1 3 3 3 2 Acyl-CoA dehydrogenase, C-terminal domain Med3 PF11593.3 CDI77747.1 - 5.1 6.2 7.5 9.1 5.4 5.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pr_beta_C PF12465.3 CDI77748.1 - 0.3 10.3 0.0 0.62 9.3 0.0 1.4 1 0 0 1 1 1 0 Proteasome beta subunits C terminal Spt20 PF12090.3 CDI77748.1 - 4.2 6.6 17.9 1.1 8.5 1.7 4.3 4 0 0 4 4 4 0 Spt20 family SMC_N PF02463.14 CDI77751.1 - 0.0001 21.6 0.1 0.00012 21.4 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 CDI77751.1 - 0.017 15.0 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Toprim PF01751.17 CDI77751.1 - 0.031 14.2 0.1 0.045 13.7 0.1 1.3 1 1 0 1 1 1 0 Toprim domain Thioredoxin PF00085.15 CDI77753.1 - 5.4e-11 42.0 0.1 7.6e-07 28.7 0.0 3.1 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 CDI77753.1 - 5.9e-08 32.7 4.8 0.00015 21.6 1.2 3.1 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDI77753.1 - 1.6e-05 24.9 0.1 0.28 11.3 0.0 3.4 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CDI77753.1 - 9.6e-05 22.5 0.0 0.47 10.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain HyaE PF07449.6 CDI77753.1 - 0.011 15.6 0.0 0.47 10.3 0.0 2.8 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE TrbC_Ftype PF09673.5 CDI77753.1 - 0.029 13.9 1.9 2.3 7.8 0.0 3.6 4 1 1 5 5 5 0 Type-F conjugative transfer system pilin assembly protein AlaDh_PNT_C PF01262.16 CDI77754.1 - 1.2e-47 161.5 0.1 2.3e-47 160.7 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 CDI77754.1 - 8.1e-37 126.2 0.0 2.9e-21 75.8 0.1 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.14 CDI77754.1 - 1.3e-06 27.7 0.1 1.9e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.22 CDI77754.1 - 7.6e-05 23.0 0.1 0.00015 22.0 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CDI77754.1 - 0.00024 21.0 0.0 0.00041 20.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CDI77754.1 - 0.00048 20.2 0.0 0.0014 18.7 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 CDI77754.1 - 0.00056 20.1 0.1 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding GIDA PF01134.17 CDI77754.1 - 0.0022 16.9 0.1 0.0032 16.4 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.9 CDI77754.1 - 0.005 15.3 1.2 0.007 14.8 0.8 1.1 1 0 0 1 1 1 1 HI0933-like protein 3HCDH_N PF02737.13 CDI77754.1 - 0.0051 16.4 0.1 0.0092 15.6 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 CDI77754.1 - 0.0069 15.3 2.6 0.0069 15.3 1.8 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 CDI77754.1 - 0.0086 15.4 0.2 0.074 12.4 0.2 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 CDI77754.1 - 0.017 15.1 0.3 0.066 13.2 0.1 2.0 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_2 PF00890.19 CDI77754.1 - 0.018 13.8 3.8 0.028 13.2 2.6 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.1 CDI77754.1 - 0.022 14.7 1.8 0.23 11.4 0.8 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 CDI77754.1 - 0.061 12.3 1.4 0.11 11.5 1.0 1.4 1 0 0 1 1 1 0 FAD binding domain PYC_OADA PF02436.13 CDI77754.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Conserved carboxylase domain FAD_oxidored PF12831.2 CDI77754.1 - 0.3 10.1 4.3 0.44 9.5 3.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase ACP_syn_III PF08545.5 CDI77756.1 - 7e-24 83.2 3.7 7.8e-24 83.1 0.4 2.6 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.5 CDI77756.1 - 8.5e-22 76.9 3.7 1.7e-11 43.9 0.1 3.4 2 1 1 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.10 CDI77756.1 - 0.02 14.8 0.1 0.17 11.8 0.0 2.1 1 1 1 2 2 2 0 Chalcone and stilbene synthases, C-terminal domain Pex14_N PF04695.8 CDI77756.1 - 0.022 14.8 0.5 0.047 13.7 0.1 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Thiolase_C PF02803.13 CDI77756.1 - 0.1 12.0 0.1 15 5.0 0.0 2.4 2 0 0 2 2 2 0 Thiolase, C-terminal domain PGM_PMM_I PF02878.11 CDI77757.1 - 3.1e-39 133.5 0.0 1.3e-38 131.6 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 CDI77757.1 - 7e-19 68.0 0.0 3.5e-18 65.8 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 CDI77757.1 - 1.5e-06 28.2 0.0 3.2e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Pkinase PF00069.20 CDI77758.1 - 1e-15 57.6 9.0 1.9e-07 30.4 0.2 4.6 3 1 0 3 3 3 2 Protein kinase domain MIP-T3 PF10243.4 CDI77758.1 - 5.4e-06 25.1 19.4 5.4e-06 25.1 13.5 5.1 2 2 3 5 5 5 1 Microtubule-binding protein MIP-T3 Pkinase_Tyr PF07714.12 CDI77758.1 - 0.0011 18.0 9.0 0.075 12.0 0.2 3.4 3 0 0 3 3 3 2 Protein tyrosine kinase RR_TM4-6 PF06459.7 CDI77758.1 - 0.0012 18.7 8.0 0.0012 18.7 5.5 7.9 7 1 1 8 8 8 1 Ryanodine Receptor TM 4-6 HCO3_cotransp PF00955.16 CDI77758.1 - 7.2 5.1 5.7 19 3.7 4.0 1.7 1 0 0 1 1 1 0 HCO3- transporter family Peptidase_C12 PF01088.16 CDI77759.1 - 2.7e-42 144.3 4.7 3.4e-38 130.9 0.3 2.6 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase, family 1 RP-C_C PF11800.3 CDI77759.1 - 0.036 13.7 10.6 0.058 13.0 3.2 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region Pol_alpha_B_N PF08418.5 CDI77759.1 - 0.077 12.5 7.5 2.4 7.6 1.7 2.1 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal CDK2AP PF09806.4 CDI77759.1 - 0.1 12.8 14.7 0.047 13.9 7.6 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein DUF966 PF06136.8 CDI77759.1 - 0.89 8.9 7.0 1.7 7.9 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Hydrolase_2 PF07486.7 CDI77759.1 - 1.5 9.3 5.4 0.57 10.7 0.3 2.7 2 1 0 2 2 2 0 Cell Wall Hydrolase Calici_coat PF00915.15 CDI77759.1 - 1.8 7.4 4.4 2.9 6.7 3.1 1.2 1 0 0 1 1 1 0 Calicivirus coat protein SOG2 PF10428.4 CDI77759.1 - 1.9 7.0 10.1 0.1 11.2 3.2 1.5 2 0 0 2 2 2 0 RAM signalling pathway protein DUF4414 PF14377.1 CDI77759.1 - 3.1 7.7 10.3 0.16 11.9 2.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4414) DUF2360 PF10152.4 CDI77759.1 - 4.7 7.4 7.6 1.7 8.8 2.1 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Hamartin PF04388.7 CDI77759.1 - 6.6 5.2 12.5 5 5.6 0.9 2.1 2 0 0 2 2 2 0 Hamartin protein LMBR1 PF04791.11 CDI77761.1 - 0.001 17.7 0.2 0.0019 16.8 0.1 1.5 1 1 0 1 1 1 1 LMBR1-like membrane protein Borrelia_P83 PF05262.6 CDI77761.1 - 0.0022 16.3 23.3 0.0023 16.2 16.2 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein Plasmodium_Vir PF05795.6 CDI77761.1 - 0.0073 15.5 0.0 0.0073 15.5 0.0 2.2 1 1 1 2 2 2 1 Plasmodium vivax Vir protein Na_trans_assoc PF06512.8 CDI77761.1 - 1.5 8.7 32.3 0.099 12.6 17.2 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated DUF605 PF04652.11 CDI77761.1 - 6.2 6.1 42.1 0.13 11.6 23.2 2.0 2 0 0 2 2 2 0 Vta1 like DUF1180 PF06679.7 CDI77761.1 - 9 6.1 10.4 0.11 12.3 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Ank_2 PF12796.2 CDI77763.1 - 2.4e-08 34.2 0.1 4.6e-08 33.3 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CDI77763.1 - 7.3e-05 22.3 0.4 0.026 14.3 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.1 CDI77763.1 - 0.00028 20.8 0.1 0.15 12.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 CDI77763.1 - 0.00031 21.1 0.1 0.0005 20.5 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDI77763.1 - 0.012 15.8 1.0 0.039 14.1 0.2 2.1 1 1 1 2 2 2 0 Ankyrin repeats (many copies) PAT1 PF09770.4 CDI77763.1 - 0.048 11.9 29.8 0.05 11.8 20.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 IER PF05760.7 CDI77763.1 - 0.097 12.5 18.7 0.13 12.1 12.9 1.2 1 0 0 1 1 1 0 Immediate early response protein (IER) TFIIA PF03153.8 CDI77763.1 - 0.17 11.7 25.1 0.22 11.3 17.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WHG PF13305.1 CDI77763.1 - 0.18 12.4 0.1 0.18 12.4 0.1 3.0 2 1 1 3 3 3 0 WHG domain GPCR_chapero_1 PF11904.3 CDI77763.1 - 0.18 10.9 5.0 0.26 10.3 3.5 1.2 1 0 0 1 1 1 0 GPCR-chaperone Neur_chan_memb PF02932.11 CDI77763.1 - 0.4 10.5 5.0 0.57 10.0 3.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PLRV_ORF5 PF01690.12 CDI77763.1 - 0.6 9.1 11.8 0.66 9.0 8.2 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Hid1 PF12722.2 CDI77763.1 - 0.65 7.6 10.5 0.78 7.3 7.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MMR1 PF08505.5 CDI77763.1 - 1.4 8.8 14.5 2.1 8.3 10.0 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Med15 PF09606.5 CDI77763.1 - 3.6 5.6 38.5 5.2 5.1 26.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SSP160 PF06933.6 CDI77764.1 - 3 5.7 20.1 3.9 5.3 13.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RAP1 PF07218.6 CDI77764.1 - 3.5 5.5 12.3 3.7 5.5 8.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SAP18 PF06487.7 CDI77765.1 - 4.6e-23 81.2 0.0 8.3e-23 80.4 0.0 1.4 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) PP2C PF00481.16 CDI77766.1 - 1.4e-60 204.8 0.2 1.4e-60 204.8 0.2 2.5 2 0 0 2 2 2 1 Protein phosphatase 2C TFIIA PF03153.8 CDI77767.1 - 1.6e-06 28.2 31.6 1.6e-06 28.2 21.9 7.4 5 3 1 6 6 6 1 Transcription factor IIA, alpha/beta subunit DUF1510 PF07423.6 CDI77767.1 - 4.4e-05 22.9 2.2 4.4e-05 22.9 1.5 6.7 6 1 0 6 6 6 2 Protein of unknown function (DUF1510) Ycf1 PF05758.7 CDI77767.1 - 0.00095 17.0 0.5 0.00095 17.0 0.3 4.6 4 1 0 4 4 4 2 Ycf1 Med15 PF09606.5 CDI77767.1 - 0.0011 17.3 62.7 0.0011 17.3 43.5 5.5 4 1 1 5 5 5 3 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI77767.1 - 0.0014 17.4 57.5 0.0014 17.4 39.9 6.7 6 0 0 6 6 6 1 Transcriptional activator LAG-3 BAF1_ABF1 PF04684.8 CDI77767.1 - 0.0019 17.1 23.8 0.0019 17.1 16.5 14.6 11 3 3 15 15 15 3 BAF1 / ABF1 chromatin reorganising factor OmpH PF03938.9 CDI77769.1 - 0.0022 17.9 5.1 0.0022 17.9 3.6 4.0 3 1 0 3 3 3 1 Outer membrane protein (OmpH-like) CBF PF03914.12 CDI77771.1 - 3.1e-09 36.4 0.1 3.1e-09 36.4 0.0 5.7 7 1 0 7 7 7 1 CBF/Mak21 family COPI_assoc PF08507.5 CDI77771.1 - 0.066 12.8 0.1 0.33 10.6 0.0 2.2 1 0 0 1 1 1 0 COPI associated protein RIC3 PF15361.1 CDI77772.1 - 0.024 14.8 0.0 0.024 14.8 0.0 10.8 10 2 1 11 11 11 0 Resistance to inhibitors of cholinesterase homologue 3 PAP1 PF08601.5 CDI77773.1 - 0.024 14.3 9.7 0.029 14.0 6.7 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Macoilin PF09726.4 CDI77773.1 - 0.13 10.5 18.9 0.16 10.2 13.1 1.1 1 0 0 1 1 1 0 Transmembrane protein CytochromB561_N PF09786.4 CDI77773.1 - 0.19 10.1 13.4 0.23 9.8 9.3 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal Golgin_A5 PF09787.4 CDI77773.1 - 0.3 9.5 18.0 0.41 9.1 12.5 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF2217 PF10265.4 CDI77773.1 - 0.39 9.4 11.5 0.48 9.1 8.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) PRP3 PF08572.5 CDI77773.1 - 1.2 8.4 8.1 0.28 10.5 2.6 1.8 1 1 1 2 2 2 0 pre-mRNA processing factor 3 (PRP3) SOBP PF15279.1 CDI77773.1 - 1.7 8.9 8.7 2.3 8.5 6.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein TFIIA PF03153.8 CDI77773.1 - 3.6 7.3 11.5 4.8 6.9 8.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRP-alpha_N PF04086.8 CDI77773.1 - 3.9 6.7 13.0 5.7 6.2 9.0 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Sec3_C PF09763.4 CDI77773.1 - 4.3 5.3 8.7 5.1 5.0 6.0 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 Peptidase_S64 PF08192.6 CDI77773.1 - 6.5 4.9 10.3 7.7 4.7 7.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 SSP160 PF06933.6 CDI77773.1 - 7.7 4.3 22.3 9.9 4.0 15.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Radical_SAM PF04055.16 CDI77774.1 - 1.2e-08 35.2 0.0 1.8e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Dehydrin PF00257.14 CDI77776.1 - 0.0011 19.3 3.0 0.38 11.0 0.3 2.4 2 0 0 2 2 2 2 Dehydrin zf-Tim10_DDP PF02953.10 CDI77777.1 - 8.9e-12 44.1 1.2 1.2e-11 43.6 0.8 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger LRR_4 PF12799.2 CDI77778.1 - 2.1e-09 36.7 14.2 1.9e-06 27.3 1.3 3.3 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI77778.1 - 5.8e-06 25.9 7.7 5.8e-06 25.9 5.4 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.1 CDI77778.1 - 0.22 11.6 10.0 0.27 11.3 0.1 4.0 3 1 1 4 4 4 0 Leucine Rich repeat YjgP_YjgQ PF03739.9 CDI77778.1 - 1.3 7.6 6.1 2.1 6.9 4.2 1.4 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family LRR_1 PF00560.28 CDI77778.1 - 2 8.7 18.4 0.49 10.6 0.2 4.4 3 1 1 4 4 4 0 Leucine Rich Repeat Metallophos PF00149.23 CDI77780.1 - 2.3e-09 36.9 0.1 3.9e-08 32.9 0.1 2.5 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDI77780.1 - 0.00026 20.8 0.0 0.00051 19.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF3371 PF11851.3 CDI77780.1 - 0.097 13.3 4.6 0.2 12.3 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Ribosomal_60s PF00428.14 CDI77780.1 - 4.6 7.7 17.0 12 6.3 11.8 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Chorion_2 PF03964.10 CDI77782.1 - 1.6 9.2 5.1 2.1 8.9 3.5 1.2 1 0 0 1 1 1 0 Chorion family 2 USP8_interact PF08941.5 CDI77783.1 - 0.033 13.5 0.9 0.033 13.5 0.6 1.6 2 0 0 2 2 2 0 USP8 interacting Neur_chan_memb PF02932.11 CDI77783.1 - 0.85 9.4 3.3 1 9.1 2.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4602 PF15375.1 CDI77783.1 - 3 7.9 16.3 0.099 12.7 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4602) AAA_23 PF13476.1 CDI77783.1 - 5.6 7.2 9.2 7.8 6.7 6.4 1.2 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 CDI77785.1 - 2.4e-52 177.6 1.1 5.5e-25 87.9 0.1 4.0 1 1 2 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77785.1 - 2.6e-21 75.8 5.6 2.3e-15 56.3 0.1 3.8 2 1 2 4 4 4 3 Protein tyrosine kinase SOBP PF15279.1 CDI77785.1 - 0.0016 18.9 19.1 0.0016 18.9 13.2 2.6 3 0 0 3 3 3 1 Sine oculis-binding protein Spore_coat_CotO PF14153.1 CDI77785.1 - 0.44 9.9 31.4 0.0081 15.6 5.3 3.6 3 0 0 3 3 3 0 Spore coat protein CotO CAF-1_p150 PF11600.3 CDI77785.1 - 0.83 8.9 43.7 2.8 7.2 7.0 3.2 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3801 PF12687.2 CDI77785.1 - 4.8 6.6 35.5 1.4 8.4 11.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3801) zf-ribbon_3 PF13248.1 CDI77786.1 - 0.011 14.9 0.1 2.4 7.4 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CDI77786.1 - 0.088 12.3 0.9 0.16 11.4 0.6 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DUF35_N PF12172.3 CDI77786.1 - 2.5 8.1 5.7 3.6 7.6 1.1 2.7 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) POP1 PF06978.6 CDI77787.1 - 1e-31 110.0 11.0 1e-31 110.0 7.6 6.3 5 1 0 6 6 6 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 CDI77787.1 - 4.3e-06 26.4 0.0 4.3e-06 26.4 0.0 5.2 6 1 0 6 6 6 1 POPLD (NUC188) domain Med15 PF09606.5 CDI77787.1 - 0.0014 16.9 48.9 0.0014 16.9 33.9 6.2 6 0 0 6 6 6 4 ARC105 or Med15 subunit of Mediator complex non-fungal DcuC PF03606.10 CDI77787.1 - 0.0043 15.3 0.5 0.0043 15.3 0.4 2.3 3 0 0 3 3 3 1 C4-dicarboxylate anaerobic carrier Plasmodium_Vir PF05795.6 CDI77787.1 - 0.049 12.8 0.3 10 5.1 0.0 3.9 4 1 0 4 4 4 0 Plasmodium vivax Vir protein UPF0565 PF10561.4 CDI77787.1 - 0.65 8.8 7.0 2.5 6.8 0.8 3.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 DEC-1_N PF04625.8 CDI77789.1 - 0.026 13.2 6.2 0.032 12.9 4.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region UQ_con PF00179.21 CDI77790.1 - 5.8e-18 64.6 0.0 9.6e-18 63.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.6 CDI77790.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 DUF2956 PF11169.3 CDI77791.1 - 0.0083 16.0 13.6 0.0083 16.0 9.5 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2956) Spt20 PF12090.3 CDI77791.1 - 0.3 10.4 7.5 0.41 9.9 5.2 1.4 1 0 0 1 1 1 0 Spt20 family FimP PF09766.4 CDI77791.1 - 0.4 9.6 16.9 0.56 9.2 11.7 1.1 1 0 0 1 1 1 0 Fms-interacting protein Mitofilin PF09731.4 CDI77791.1 - 0.51 8.9 25.3 0.65 8.5 17.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LCD1 PF09798.4 CDI77791.1 - 2.3 6.1 8.7 2.9 5.7 6.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Ndc1_Nup PF09531.5 CDI77791.1 - 2.5 6.3 10.5 2.8 6.2 7.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.4 CDI77791.1 - 4.2 5.5 14.3 6 5.0 9.9 1.2 1 0 0 1 1 1 0 Transmembrane protein PAT1 PF09770.4 CDI77791.1 - 6.5 4.8 30.9 7.8 4.6 21.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PLRV_ORF5 PF01690.12 CDI77791.1 - 7.8 5.5 16.2 9.2 5.2 11.2 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein RNase_P_p30 PF01876.11 CDI77792.1 - 1.2e-19 70.0 0.0 2.9e-18 65.5 0.0 2.4 1 1 0 1 1 1 1 RNase P subunit p30 DEAD PF00270.24 CDI77793.1 - 6.3e-34 116.9 0.1 6.3e-34 116.9 0.1 3.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI77793.1 - 8.4e-19 67.2 0.0 8.4e-19 67.2 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CDI77793.1 - 7.6e-14 51.0 0.1 2.7e-13 49.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Rtf2 PF04641.7 CDI77794.1 - 0.015 14.4 26.6 0.022 13.9 18.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger PLRV_ORF5 PF01690.12 CDI77794.1 - 1.6 7.7 18.5 2.5 7.1 12.9 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein YjgP_YjgQ PF03739.9 CDI77794.1 - 5.8 5.5 9.4 8.9 4.9 6.5 1.3 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Methyltransf_23 PF13489.1 CDI77795.1 - 1.7e-09 37.5 2.5 2.1e-09 37.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI77795.1 - 4.7e-06 27.0 4.3 0.034 14.6 0.2 3.3 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.1 CDI77795.1 - 7e-06 25.7 5.5 0.0071 15.9 0.1 3.5 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 CDI77795.1 - 1.6e-05 25.4 3.1 0.0001 22.8 2.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI77795.1 - 0.00022 21.6 3.9 0.0038 17.6 0.2 3.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI77795.1 - 0.00092 19.2 5.7 0.00092 19.2 4.0 3.4 2 2 0 2 2 2 1 Methyltransferase domain Fucokinase PF07959.7 CDI77795.1 - 0.0051 15.4 0.2 0.36 9.3 0.0 2.3 2 0 0 2 2 2 1 L-fucokinase Methyltransf_25 PF13649.1 CDI77795.1 - 0.023 15.0 2.2 0.16 12.3 1.5 2.6 1 1 0 1 1 1 0 Methyltransferase domain EphA2_TM PF14575.1 CDI77797.1 - 0.08 13.3 0.1 0.3 11.4 0.1 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF788 PF05620.6 CDI77797.1 - 0.57 10.0 2.2 2 8.2 1.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF788) eIF3g PF12353.3 CDI77798.1 - 2.8e-15 56.3 0.6 2.8e-15 56.3 0.4 2.5 1 1 2 3 3 3 1 Eukaryotic translation initiation factor 3 subunit G DUF2407_C PF13373.1 CDI77798.1 - 0.0061 16.4 0.3 0.012 15.5 0.2 1.5 1 0 0 1 1 1 1 DUF2407 C-terminal domain DNA_pol_viral_N PF00242.12 CDI77798.1 - 0.98 8.3 13.9 1.2 8.1 9.6 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF572 PF04502.8 CDI77798.1 - 1.1 8.3 12.8 1.7 7.8 8.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.4 CDI77798.1 - 2 6.6 18.6 2.5 6.2 12.9 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF716 PF04819.7 CDI77799.1 - 0.01 15.2 2.4 0.016 14.6 1.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF716) Ribosomal_60s PF00428.14 CDI77799.1 - 0.95 9.8 15.4 1.1 9.6 0.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3995 PF13160.1 CDI77799.1 - 7.8 6.5 11.1 5.2 7.1 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) Cir_Bir_Yir PF06022.6 CDI77800.1 - 0.49 9.5 3.4 1.3 8.1 2.4 1.6 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir Ycf1 PF05758.7 CDI77800.1 - 2.4 5.7 5.3 3.6 5.1 3.7 1.2 1 0 0 1 1 1 0 Ycf1 DUF3633 PF12315.3 CDI77801.1 - 3.5e-11 42.8 9.9 4.3e-09 35.9 2.1 3.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3633) LIM PF00412.17 CDI77801.1 - 0.004 17.1 34.5 0.028 14.4 0.4 5.1 5 1 1 6 6 6 4 LIM domain EF-hand_7 PF13499.1 CDI77802.1 - 2.8e-08 33.7 0.3 7.7e-08 32.3 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI77802.1 - 1.7e-06 26.8 1.2 0.034 13.4 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CDI77802.1 - 0.00021 20.9 0.6 0.094 12.6 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 CDI77802.1 - 0.0051 16.3 0.0 0.011 15.2 0.0 1.6 1 1 0 1 1 1 1 EF-hand domain pair PHD PF00628.24 CDI77803.1 - 0.00031 20.3 8.3 0.0018 17.9 3.9 3.1 2 0 0 2 2 2 1 PHD-finger zf-MIZ PF02891.15 CDI77805.1 - 1.5e-06 27.6 7.2 8.2e-05 22.0 0.0 3.3 3 0 0 3 3 3 2 MIZ/SP-RING zinc finger Ribosomal_60s PF00428.14 CDI77805.1 - 0.027 14.8 4.2 0.027 14.8 2.9 9.8 5 3 3 8 8 8 0 60s Acidic ribosomal protein RPA_interact_C PF14768.1 CDI77805.1 - 0.56 10.6 2.7 16 5.9 0.1 3.2 3 0 0 3 3 3 0 Replication protein A interacting C-terminal Cas_Cas5d PF09704.5 CDI77807.1 - 0.1 12.2 2.1 0.29 10.7 0.2 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas5) DUF3558 PF12079.3 CDI77810.1 - 0.026 14.1 1.3 0.03 13.9 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) Spore_YhcN_YlaJ PF09580.5 CDI77810.1 - 0.2 11.7 9.2 0.22 11.6 6.4 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PCYCGC PF13798.1 CDI77810.1 - 0.22 11.2 4.5 0.26 10.9 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif Conotoxin PF02950.12 CDI77810.1 - 0.25 12.1 5.4 0.37 11.6 3.7 1.3 1 0 0 1 1 1 0 Conotoxin ERF PF04404.7 CDI77810.1 - 0.52 9.8 14.1 0.57 9.6 9.8 1.1 1 0 0 1 1 1 0 ERF superfamily Slu7 PF11708.3 CDI77810.1 - 0.62 9.7 12.2 0.66 9.6 8.4 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor FAM176 PF14851.1 CDI77810.1 - 0.7 9.5 3.9 0.8 9.3 2.7 1.1 1 0 0 1 1 1 0 FAM176 family polyprenyl_synt PF00348.12 CDI77810.1 - 1.4 7.7 7.8 1.5 7.6 5.4 1.0 1 0 0 1 1 1 0 Polyprenyl synthetase PepSY_2 PF13670.1 CDI77810.1 - 1.5 8.7 4.1 1.9 8.4 2.8 1.2 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Fungal_trans_2 PF11951.3 CDI77810.1 - 1.5 7.3 8.7 1.5 7.3 6.0 1.0 1 0 0 1 1 1 0 Fungal specific transcription factor domain zf-ZPR1 PF03367.8 CDI77810.1 - 1.7 7.7 6.1 1.8 7.7 4.2 1.0 1 0 0 1 1 1 0 ZPR1 zinc-finger domain Virul_fac_BrkB PF03631.10 CDI77810.1 - 1.9 7.8 3.9 2.1 7.6 2.7 1.0 1 0 0 1 1 1 0 Virulence factor BrkB DUF2149 PF09919.4 CDI77810.1 - 2.3 8.3 4.8 2.9 8.0 3.3 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) Ctr PF04145.10 CDI77810.1 - 2.6 8.0 4.3 2.7 8.0 3.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family FHIPEP PF00771.15 CDI77810.1 - 2.8 6.1 7.0 2.9 6.0 4.8 1.0 1 0 0 1 1 1 0 FHIPEP family PP_kinase_N PF13089.1 CDI77810.1 - 3.1 7.9 9.4 3.6 7.7 6.5 1.1 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain IncA PF04156.9 CDI77810.1 - 3.5 7.1 22.1 3.9 7.0 15.3 1.1 1 0 0 1 1 1 0 IncA protein GN3L_Grn1 PF08701.6 CDI77810.1 - 3.8 7.4 13.3 9.8 6.1 9.2 1.7 1 1 0 1 1 1 0 GNL3L/Grn1 putative GTPase eIF-3_zeta PF05091.7 CDI77810.1 - 4 5.9 13.2 4.2 5.8 9.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Cellulose_synt PF03552.9 CDI77810.1 - 4.7 5.3 5.2 4.4 5.4 3.6 1.0 1 0 0 1 1 1 0 Cellulose synthase AIF_C PF14721.1 CDI77810.1 - 5.3 7.3 7.0 5.3 7.2 4.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ATAD4 PF15321.1 CDI77810.1 - 5.8 8.0 8.1 6.3 7.8 5.6 1.2 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 zf-DHHC PF01529.15 CDI77810.1 - 7.7 5.8 6.4 8.2 5.7 4.4 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF4175 PF13779.1 CDI77810.1 - 8.5 3.9 26.9 8 4.0 18.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF1980 PF09323.5 CDI77810.1 - 8.7 6.0 8.7 9 6.0 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Med15 PF09606.5 CDI77810.1 - 9.9 4.2 35.3 9.6 4.2 24.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal OATP PF03137.15 CDI77810.1 - 10 4.0 7.7 10 4.0 5.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family AMA-1 PF02430.10 CDI77811.1 - 6.5e-36 124.2 0.7 1.7e-20 73.3 0.0 3.1 1 1 2 3 3 3 3 Apical membrane antigen 1 DUF4366 PF14283.1 CDI77811.1 - 0.019 14.3 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF755 PF05501.6 CDI77812.1 - 0.0067 16.4 20.4 0.0067 16.4 14.2 6.7 6 0 0 6 6 6 2 Domain of unknown function (DUF755) Sec7 PF01369.15 CDI77813.1 - 3.5e-46 157.2 0.0 5.8e-46 156.5 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain RabGAP-TBC PF00566.13 CDI77813.1 - 1.9e-31 109.2 1.3 7.7e-31 107.2 0.8 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Mcp5_PH PF12814.2 CDI77813.1 - 0.26 11.2 0.0 0.51 10.2 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Sulfate_transp PF00916.15 CDI77814.1 - 4.2e-40 137.5 7.3 6.4e-31 107.3 1.9 2.4 2 0 0 2 2 2 2 Sulfate transporter family Sulfate_tra_GLY PF13792.1 CDI77814.1 - 7.5e-25 86.4 1.2 7.5e-25 86.4 0.8 2.6 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 CDI77814.1 - 2.3e-17 62.4 0.0 3.7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 CDI77814.1 - 0.0066 16.4 0.0 0.021 14.8 0.0 2.0 1 0 0 1 1 1 1 STAS domain zf-MIZ PF02891.15 CDI77815.1 - 1.3e-16 59.8 4.1 4.5e-16 58.1 2.9 2.1 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 CDI77815.1 - 6.5e-09 35.0 0.0 1.2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 SAP domain PHD_2 PF13831.1 CDI77815.1 - 0.01 15.1 0.5 0.01 15.1 0.4 2.8 3 1 0 3 3 3 1 PHD-finger PHD PF00628.24 CDI77815.1 - 0.33 10.6 13.9 0.68 9.6 2.0 3.3 2 1 1 3 3 3 0 PHD-finger Prominin PF05478.6 CDI77817.1 - 0.0064 14.0 0.8 0.0078 13.8 0.5 1.1 1 0 0 1 1 1 1 Prominin Apolipoprotein PF01442.13 CDI77817.1 - 0.0088 15.5 11.4 0.015 14.8 7.9 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.10 CDI77817.1 - 0.013 14.7 3.1 0.018 14.2 2.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ApoLp-III PF07464.6 CDI77817.1 - 0.036 14.0 5.1 0.063 13.3 3.5 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) PIN_4 PF13638.1 CDI77817.1 - 0.11 12.6 1.7 0.13 12.3 0.5 1.5 2 0 0 2 2 2 0 PIN domain SKIP_SNW PF02731.10 CDI77817.1 - 0.16 11.3 6.3 0.32 10.4 3.5 1.9 1 1 1 2 2 2 0 SKIP/SNW domain Adeno_PIX PF03955.9 CDI77817.1 - 0.18 12.3 4.0 1.7 9.2 2.8 2.4 1 1 0 1 1 1 0 Adenovirus hexon-associated protein (IX) AAA_13 PF13166.1 CDI77817.1 - 0.25 9.7 2.8 0.36 9.2 1.9 1.1 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 CDI77817.1 - 0.29 9.5 2.2 0.38 9.1 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Coat_F PF07875.7 CDI77817.1 - 0.34 11.0 2.2 0.89 9.7 1.5 1.7 1 0 0 1 1 1 0 Coat F domain OmpH PF03938.9 CDI77817.1 - 0.71 9.8 13.0 0.85 9.5 9.0 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) ING PF12998.2 CDI77817.1 - 2.2 8.6 9.6 4.5 7.5 6.7 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding YlqD PF11068.3 CDI77817.1 - 2.9 7.9 12.8 6.2 6.8 8.9 1.6 1 0 0 1 1 1 0 YlqD protein ATP-synt_B PF00430.13 CDI77817.1 - 2.9 7.6 11.4 0.61 9.9 5.3 1.7 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Aminotran_1_2 PF00155.16 CDI77817.1 - 5.9 5.7 5.5 13 4.6 2.9 1.9 1 1 1 2 2 2 0 Aminotransferase class I and II Nop PF01798.13 CDI77818.1 - 4.4e-28 97.4 4.0 8.3e-28 96.5 2.8 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 CDI77818.1 - 1.6e-15 57.6 5.6 1.6e-15 57.6 3.9 1.8 2 0 0 2 2 2 1 Prp31 C terminal domain NOSIC PF08060.8 CDI77818.1 - 1.2e-05 24.9 1.6 0.00012 21.8 1.1 2.2 1 1 0 1 1 1 1 NOSIC (NUC001) domain Med15 PF09606.5 CDI77819.1 - 0.6 8.2 44.0 0.87 7.7 30.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Herpes_UL87 PF03043.9 CDI77819.1 - 4.3 5.6 7.4 8.7 4.5 5.0 1.6 1 1 0 1 1 1 0 Herpesvirus UL87 family BAF1_ABF1 PF04684.8 CDI77821.1 - 0.27 10.0 7.5 0.29 9.9 5.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF866 PF05907.8 CDI77821.1 - 1.6 8.1 5.2 2.3 7.7 3.6 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) DUF4175 PF13779.1 CDI77821.1 - 9 3.8 8.3 9.6 3.7 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Dehydrin PF00257.14 CDI77822.1 - 0.092 13.0 0.0 0.092 13.0 0.0 10.6 7 4 0 8 8 8 0 Dehydrin DUF572 PF04502.8 CDI77823.1 - 0.0075 15.5 19.3 0.013 14.7 13.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF572) EF-1_beta_acid PF10587.4 CDI77823.1 - 0.049 13.7 3.8 0.049 13.7 2.6 2.9 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region Plasmodium_Vir PF05795.6 CDI77823.1 - 0.097 11.8 5.5 0.13 11.4 3.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MRC1 PF09444.5 CDI77823.1 - 0.96 9.7 19.4 0.82 9.9 10.2 2.3 1 1 1 2 2 2 0 MRC1-like domain Med15 PF09606.5 CDI77823.1 - 1.8 6.6 45.1 2.5 6.1 31.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI77823.1 - 3.8 5.6 28.5 4.8 5.2 19.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S15 PF02129.13 CDI77823.1 - 8.8 5.6 9.0 14 4.9 6.2 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) PIG-S PF10510.4 CDI77824.1 - 0.26 9.9 12.4 0.31 9.6 8.6 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF572 PF04502.8 CDI77824.1 - 1.5 8.0 17.4 1.9 7.6 12.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) WD40 PF00400.27 CDI77825.1 - 1.5e-24 84.9 0.5 1e-06 28.3 0.0 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat Prp19 PF08606.6 CDI77825.1 - 3.7e-13 49.0 4.4 6.8e-13 48.1 3.1 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like TBCA PF02970.11 CDI77825.1 - 0.002 18.1 0.8 0.0036 17.3 0.6 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor A DUF1635 PF07795.6 CDI77825.1 - 0.0037 16.6 0.9 0.0058 16.0 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) PPC PF04151.10 CDI77825.1 - 1.5 9.8 5.4 0.26 12.2 0.5 2.3 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain Macoilin PF09726.4 CDI77825.1 - 3.7 5.7 8.2 4.8 5.3 5.7 1.1 1 0 0 1 1 1 0 Transmembrane protein SSP160 PF06933.6 CDI77826.1 - 9.4e-07 27.2 18.2 9.4e-07 27.2 12.6 3.2 3 0 0 3 3 3 2 Special lobe-specific silk protein SSP160 MAS20 PF02064.10 CDI77826.1 - 0.34 10.8 0.1 0.34 10.8 0.1 3.2 3 0 0 3 3 3 0 MAS20 protein import receptor OmpH PF03938.9 CDI77826.1 - 0.93 9.4 40.4 0.4 10.5 19.4 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Plasmodium_Vir PF05795.6 CDI77826.1 - 5.2 6.1 24.4 0.17 11.0 4.1 2.7 3 0 0 3 3 3 0 Plasmodium vivax Vir protein ubiquitin PF00240.18 CDI77828.1 - 6.8e-43 143.9 1.8 2.2e-35 119.8 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 CDI77828.1 - 7.8e-24 83.1 0.3 1.2e-20 72.9 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDI77828.1 - 3.5e-08 33.5 0.3 4.6e-06 26.8 0.1 2.7 2 1 0 2 2 2 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CDI77828.1 - 3.1e-05 23.7 0.0 0.00024 20.8 0.0 1.9 2 0 0 2 2 2 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 CDI77828.1 - 0.0038 17.0 0.0 0.011 15.6 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CDI77828.1 - 0.019 15.1 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TUG-UBL1 PF11470.3 CDI77828.1 - 0.056 13.3 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 GLUT4 regulating protein TUG Plexin_cytopl PF08337.7 CDI77828.1 - 0.082 11.2 0.6 1.9 6.7 0.1 2.5 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain DUF2870 PF11069.3 CDI77828.1 - 0.11 12.5 0.0 0.29 11.2 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2870) HMG_box PF00505.14 CDI77829.1 - 1.3e-14 54.2 2.8 3.8e-14 52.7 1.9 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDI77829.1 - 6.3e-06 26.4 2.4 2.7e-05 24.4 1.7 2.2 1 0 0 1 1 1 1 HMG-box domain SET PF00856.23 CDI77829.1 - 0.002 18.4 0.0 0.002 18.4 0.0 5.6 4 3 0 4 4 4 1 SET domain SLIDE PF09111.5 CDI77834.1 - 1.3e-11 44.2 0.0 2.2e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 SLIDE SOBP PF15279.1 CDI77834.1 - 2.1 8.6 9.2 3.3 8.0 6.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein SNF2_N PF00176.18 CDI77835.1 - 4.8e-63 212.7 2.8 2.2e-61 207.2 1.9 3.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDI77835.1 - 6e-07 29.2 1.0 1.8e-06 27.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain BSP_II PF05432.6 CDI77835.1 - 0.005 16.1 6.7 0.005 16.1 4.6 2.4 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) AAA_14 PF13173.1 CDI77835.1 - 0.027 14.3 0.0 0.57 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mem_trans PF03547.13 CDI77835.1 - 0.38 8.9 1.4 7.3 4.7 0.1 2.4 2 0 0 2 2 2 0 Membrane transport protein PDEase_I PF00233.14 CDI77836.1 - 2.4e-49 168.2 0.2 2.5e-49 168.1 0.1 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Antiterm PF03589.8 CDI77836.1 - 0.037 14.1 0.0 0.3 11.1 0.0 2.3 2 0 0 2 2 2 0 Antitermination protein HD PF01966.17 CDI77836.1 - 0.053 13.5 0.9 0.14 12.1 0.3 2.1 1 1 1 2 2 2 0 HD domain SR-25 PF10500.4 CDI77837.1 - 5.9 6.2 9.3 8.2 5.8 6.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glutaredoxin PF00462.19 CDI77838.1 - 8.4e-18 64.1 0.0 2.1e-17 62.8 0.0 1.6 2 0 0 2 2 2 1 Glutaredoxin PCI PF01399.22 CDI77840.1 - 4.7e-21 75.0 1.1 7.7e-21 74.3 0.0 2.0 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.6 CDI77840.1 - 4.7e-11 42.9 0.1 4.7e-11 42.9 0.1 4.2 3 1 1 4 4 4 2 Proteasome regulatory subunit C-terminal Secretin_N_2 PF07655.8 CDI77840.1 - 0.00019 21.7 1.2 0.00019 21.7 0.8 3.6 3 1 1 4 4 4 1 Secretin N-terminal domain Pox_J1 PF03338.10 CDI77840.1 - 0.017 14.8 0.1 0.27 10.9 0.0 2.4 2 0 0 2 2 2 0 Poxvirus J1 protein CD20 PF04103.10 CDI77841.1 - 0.035 14.0 0.3 0.035 14.0 0.2 2.7 2 1 1 3 3 3 0 CD20-like family PAT1 PF09770.4 CDI77841.1 - 0.98 7.5 40.0 1.4 7.0 27.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GATA-N PF05349.7 CDI77841.1 - 1.1 9.3 9.4 3.5 7.7 0.1 2.4 2 0 0 2 2 2 0 GATA-type transcription activator, N-terminal Neur_chan_memb PF02932.11 CDI77841.1 - 2.8 7.7 5.4 0.97 9.2 1.8 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Rad54_N PF08658.5 CDI77841.1 - 5.6 6.6 7.3 8.2 6.1 0.2 2.5 3 0 0 3 3 3 0 Rad54 N terminal RAP1 PF07218.6 CDI77842.1 - 3.8 5.5 5.9 7 4.6 4.1 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF258 PF03193.11 CDI77843.1 - 1.9e-05 23.9 0.0 0.00011 21.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CDI77843.1 - 5.4e-05 23.2 0.2 0.00012 22.1 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CDI77843.1 - 0.0043 17.1 0.0 0.03 14.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDI77843.1 - 0.01 16.6 0.0 0.015 16.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CDI77843.1 - 0.036 13.7 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 CDI77843.1 - 0.05 13.9 0.0 0.074 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 CDI77843.1 - 0.06 12.0 0.1 0.081 11.5 0.1 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_30 PF13604.1 CDI77843.1 - 0.11 12.0 0.8 0.17 11.4 0.0 1.7 2 1 0 2 2 2 0 AAA domain RNase_H PF00075.19 CDI77844.1 - 5.2e-23 81.8 0.0 2.1e-20 73.4 0.0 2.4 1 1 0 1 1 1 1 RNase H Ribosomal_60s PF00428.14 CDI77844.1 - 0.069 13.5 30.7 0.12 12.7 6.8 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Rotamase_2 PF13145.1 CDI77844.1 - 2.7 8.6 8.0 1.2 9.7 1.1 2.2 2 0 0 2 2 2 0 PPIC-type PPIASE domain Beta-Casp PF10996.3 CDI77849.1 - 2.9e-23 82.1 0.0 1e-22 80.3 0.0 2.0 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.7 CDI77849.1 - 7.3e-12 44.9 0.0 1.4e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase CPSF73-100_C PF11718.3 CDI77849.1 - 7.3e-06 25.4 0.2 7.3e-06 25.4 0.2 3.3 3 1 1 4 4 4 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DRMBL PF07522.9 CDI77849.1 - 0.0013 18.7 0.0 0.0036 17.3 0.0 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 CDI77849.1 - 0.0022 17.5 0.0 0.036 13.6 0.0 2.3 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Ycf1 PF05758.7 CDI77849.1 - 0.0038 15.0 1.6 0.0047 14.7 1.1 1.1 1 0 0 1 1 1 1 Ycf1 FLO_LFY PF01698.11 CDI77849.1 - 0.85 8.3 8.9 2.5 6.8 6.2 1.7 1 0 0 1 1 1 0 Floricaula / Leafy protein SAC3_GANP PF03399.11 CDI77850.1 - 5e-36 124.1 1.0 5e-36 124.1 0.7 3.0 4 0 0 4 4 4 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SAGA-Tad1 PF12767.2 CDI77851.1 - 0.0042 16.8 13.2 0.0042 16.8 9.2 3.9 4 0 0 4 4 4 3 Transcriptional regulator of RNA polII, SAGA, subunit LMBR1 PF04791.11 CDI77851.1 - 0.061 11.9 11.8 0.021 13.4 2.1 2.5 2 0 0 2 2 2 0 LMBR1-like membrane protein N6_N4_Mtase PF01555.13 CDI77852.1 - 0.15 11.5 0.0 17 4.8 0.0 3.3 3 2 0 3 3 3 0 DNA methylase DUF4179 PF13786.1 CDI77853.1 - 0.092 12.9 0.5 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) MIP-T3 PF10243.4 CDI77853.1 - 0.15 10.4 28.9 0.21 10.0 20.0 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF966 PF06136.8 CDI77853.1 - 0.29 10.4 20.8 0.4 10.0 14.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Peptidase_C48 PF02902.14 CDI77854.1 - 4.3e-33 114.7 0.0 7.9e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Activator_LAG-3 PF11498.3 CDI77854.1 - 0.1 11.3 16.3 0.08 11.6 8.6 2.1 2 0 0 2 2 2 0 Transcriptional activator LAG-3 TMF_DNA_bd PF12329.3 CDI77855.1 - 0.0094 15.7 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding ERM PF00769.14 CDI77855.1 - 0.012 15.1 0.4 0.015 14.8 0.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Kinesin-related PF06548.6 CDI77855.1 - 0.038 12.5 0.3 0.051 12.1 0.2 1.1 1 0 0 1 1 1 0 Kinesin-related Tropomyosin PF00261.15 CDI77855.1 - 1.2 8.1 6.1 0.35 9.9 2.0 1.7 2 1 0 2 2 2 0 Tropomyosin Striatin PF08232.7 CDI77856.1 - 6 7.1 7.1 1.2 9.3 0.2 2.6 2 0 0 2 2 2 0 Striatin family PDEase_I PF00233.14 CDI77857.1 - 6.7e-17 62.0 0.2 3.6e-16 59.6 0.0 1.9 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase DUF3907 PF13047.1 CDI77857.1 - 0.031 13.8 0.4 0.05 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) SDH_alpha PF03313.10 CDI77858.1 - 0.029 13.4 4.2 0.05 12.6 2.9 1.3 1 0 0 1 1 1 0 Serine dehydratase alpha chain RAB3GAP2_N PF14655.1 CDI77858.1 - 0.78 8.6 8.3 0.4 9.6 0.6 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PsbW PF07123.7 CDI77858.1 - 1.9 8.5 11.8 0.1 12.6 3.3 2.1 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) DUF2360 PF10152.4 CDI77858.1 - 4.5 7.5 14.5 1.6 9.0 0.2 2.6 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein (DUF2360) GTP_EFTU PF00009.22 CDI77859.1 - 6e-38 130.1 0.0 1e-37 129.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 CDI77859.1 - 9.1e-20 70.5 0.0 2.3e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 CDI77859.1 - 1.2e-10 41.3 0.4 1.2e-10 41.3 0.3 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDI77859.1 - 0.023 14.6 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase CTP_transf_1 PF01148.15 CDI77860.1 - 0.16 11.5 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family Nop14 PF04147.7 CDI77860.1 - 0.24 9.2 32.7 0.53 8.1 12.7 2.9 2 1 1 3 3 3 0 Nop14-like family Methyltransf_18 PF12847.2 CDI77861.1 - 0.0012 19.3 3.7 0.02 15.4 0.1 2.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDI77861.1 - 0.035 13.4 0.2 0.035 13.4 0.2 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_26 PF13659.1 CDI77861.1 - 0.12 12.4 6.3 0.15 12.1 0.0 2.9 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.7 CDI77861.1 - 0.13 12.7 0.6 11 6.5 0.0 3.3 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.7 CDI77861.1 - 0.46 10.9 0.0 0.46 10.9 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain RRM_1 PF00076.17 CDI77862.1 - 8.9e-18 63.6 0.0 1.7e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI77862.1 - 1.4e-14 53.7 0.0 2.6e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI77862.1 - 9.8e-08 31.7 0.0 2.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDI77862.1 - 0.011 15.5 0.0 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Radical_SAM PF04055.16 CDI77863.1 - 6.5e-08 32.9 0.1 3.1e-06 27.4 0.1 3.0 2 1 0 2 2 2 1 Radical SAM superfamily BAF1_ABF1 PF04684.8 CDI77863.1 - 0.00077 18.4 12.5 0.00077 18.4 8.6 7.8 6 2 3 9 9 9 2 BAF1 / ABF1 chromatin reorganising factor HemN_C PF06969.11 CDI77863.1 - 0.0018 18.3 0.0 0.009 16.0 0.0 2.3 1 0 0 1 1 1 1 HemN C-terminal domain SAPS PF04499.10 CDI77863.1 - 5.8 5.4 41.4 0.088 11.4 9.0 3.7 2 1 0 3 3 3 0 SIT4 phosphatase-associated protein Ribosomal_L3 PF00297.17 CDI77864.1 - 1.5e-106 355.6 5.1 1.8e-106 355.3 3.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 SGS PF05002.10 CDI77865.1 - 1.1e-24 85.9 1.3 1.1e-24 85.9 0.9 2.0 2 0 0 2 2 2 1 SGS domain CS PF04969.11 CDI77865.1 - 5.9e-13 49.1 3.8 1e-12 48.4 1.6 2.0 2 0 0 2 2 2 1 CS domain Interfer-bind PF09294.5 CDI77865.1 - 0.11 12.5 1.1 0.21 11.6 0.8 1.5 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III GpcrRhopsn4 PF10192.4 CDI77866.1 - 0.00054 19.2 0.0 0.00085 18.5 0.0 1.3 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Claudin_2 PF13903.1 CDI77866.1 - 0.00076 19.2 0.8 0.00089 18.9 0.5 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction IncA PF04156.9 CDI77866.1 - 0.0034 17.0 9.2 0.0034 17.0 6.4 1.6 2 0 0 2 2 2 1 IncA protein DUF4414 PF14377.1 CDI77866.1 - 0.011 15.6 4.8 0.027 14.3 3.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) zf-DHHC PF01529.15 CDI77866.1 - 0.02 14.2 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Serinc PF03348.10 CDI77866.1 - 0.036 12.7 0.1 0.051 12.2 0.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) RAB3GAP2_N PF14655.1 CDI77866.1 - 0.042 12.8 5.4 0.018 14.0 2.2 1.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RskA PF10099.4 CDI77866.1 - 0.051 13.3 1.5 0.12 12.1 1.0 1.6 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DivIC PF04977.10 CDI77866.1 - 0.11 11.9 8.8 0.28 10.6 6.1 1.7 1 0 0 1 1 1 0 Septum formation initiator FimP PF09766.4 CDI77866.1 - 0.44 9.5 11.6 0.65 8.9 8.0 1.2 1 0 0 1 1 1 0 Fms-interacting protein Med15 PF09606.5 CDI77866.1 - 0.69 8.0 24.3 0.97 7.5 16.9 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI77866.1 - 0.74 9.4 8.0 1 9.0 5.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3682 PF12446.3 CDI77866.1 - 0.96 9.7 14.2 1.9 8.7 9.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) OATP PF03137.15 CDI77866.1 - 5.4 4.9 13.1 3 5.8 0.3 2.1 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Exo_endo_phos PF03372.18 CDI77867.1 - 1.1e-11 45.1 0.0 2.1e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Med15 PF09606.5 CDI77867.1 - 0.0018 16.5 40.2 0.0018 16.5 27.9 2.4 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal FHIPEP PF00771.15 CDI77867.1 - 0.11 10.7 7.8 0.047 12.0 2.0 2.0 2 0 0 2 2 2 0 FHIPEP family LRR_9 PF14580.1 CDI77868.1 - 6.7e-05 22.5 0.5 0.00011 21.7 0.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 CDI77868.1 - 8.3e-05 22.2 4.7 0.00018 21.1 3.2 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 CDI77868.1 - 0.00013 21.4 6.8 0.00022 20.7 3.6 2.0 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) Band_3_cyto PF07565.8 CDI77868.1 - 0.0063 16.0 4.0 0.0063 16.0 2.8 3.4 3 2 0 3 3 3 1 Band 3 cytoplasmic domain LRR_1 PF00560.28 CDI77868.1 - 0.03 14.3 5.4 9.2 6.7 0.3 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat SprA-related PF12118.3 CDI77869.1 - 0.00089 18.6 19.4 0.00089 18.6 13.5 11.7 8 4 1 9 9 9 4 SprA-related family PP2C PF00481.16 CDI77870.1 - 2.4e-26 92.6 0.6 7.1e-26 91.1 0.4 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Apt1 PF10351.4 CDI77870.1 - 0.035 12.9 4.3 1.4 7.6 0.5 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Phostensin_N PF13916.1 CDI77871.1 - 0.02 14.8 1.8 0.02 14.8 1.3 12.3 7 2 4 11 11 11 0 PP1-regulatory protein, Phostensin N-terminal Pkinase PF00069.20 CDI77872.1 - 1.4e-20 73.5 5.2 9.6e-12 44.5 0.0 3.1 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77872.1 - 3.8e-15 55.6 2.7 6.1e-09 35.3 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase Sporozoite_P67 PF05642.6 CDI77872.1 - 0.00066 17.6 14.8 0.00089 17.2 10.3 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen FimP PF09766.4 CDI77872.1 - 0.0049 15.9 18.6 0.016 14.3 2.0 2.1 2 0 0 2 2 2 2 Fms-interacting protein Plasmodium_Vir PF05795.6 CDI77872.1 - 0.017 14.3 0.8 0.017 14.3 0.6 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein PhdYeFM_antitox PF02604.14 CDI77872.1 - 0.047 13.2 0.0 0.047 13.2 0.0 2.2 3 0 0 3 3 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system SPX PF03105.14 CDI77872.1 - 0.053 13.3 9.6 0.068 12.9 0.4 2.2 2 0 0 2 2 2 0 SPX domain BAF1_ABF1 PF04684.8 CDI77872.1 - 0.093 11.5 33.2 0.26 10.0 11.0 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Spt20 PF12090.3 CDI77872.1 - 0.13 11.6 14.1 0.27 10.5 0.7 2.2 2 0 0 2 2 2 0 Spt20 family Med15 PF09606.5 CDI77872.1 - 0.19 9.8 40.7 0.5 8.5 12.8 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hid1 PF12722.2 CDI77872.1 - 0.36 8.4 17.6 0.061 11.0 1.6 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DDHD PF02862.12 CDI77872.1 - 0.47 10.2 15.8 0.26 11.0 0.8 2.3 2 0 0 2 2 2 0 DDHD domain FAM60A PF15396.1 CDI77872.1 - 0.53 9.9 15.8 1.6 8.4 1.7 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Striatin PF08232.7 CDI77872.1 - 0.6 10.4 14.7 1 9.6 0.8 2.4 2 0 0 2 2 2 0 Striatin family Band_3_cyto PF07565.8 CDI77872.1 - 0.6 9.5 18.6 0.46 9.9 0.7 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain APH PF01636.18 CDI77872.1 - 1.1 8.9 10.8 0.027 14.1 2.6 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family Bud13 PF09736.4 CDI77872.1 - 1.2 9.3 15.8 3 8.1 1.7 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex PIG-P PF08510.7 CDI77872.1 - 1.5 8.5 3.7 3.3 7.3 0.4 2.1 2 0 0 2 2 2 0 PIG-P Gti1_Pac2 PF09729.4 CDI77872.1 - 1.5 8.6 11.9 2.5 7.9 0.7 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Baculo_PP31 PF05311.6 CDI77872.1 - 1.8 7.7 13.9 0.34 10.1 0.8 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) U1snRNP70_N PF12220.3 CDI77872.1 - 2.1 8.7 15.9 4.5 7.6 3.4 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF2052 PF09747.4 CDI77872.1 - 2.4 8.0 17.5 4.5 7.1 5.1 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CDC27 PF09507.5 CDI77872.1 - 2.7 7.1 24.4 3.5 6.7 9.7 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Apt1 PF10351.4 CDI77872.1 - 2.7 6.7 13.4 5.5 5.7 9.3 1.4 1 1 0 1 1 1 0 Golgi-body localisation protein domain RAB3GAP2_N PF14655.1 CDI77872.1 - 4 6.3 17.4 2.2 7.2 2.3 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus AUX_IAA PF02309.11 CDI77872.1 - 4.2 7.0 16.8 3.7 7.2 1.0 2.2 2 0 0 2 2 2 0 AUX/IAA family Suf PF05843.9 CDI77872.1 - 4.4 6.9 16.5 0.94 9.1 1.3 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4557 PF15101.1 CDI77872.1 - 7.3 6.3 25.7 3.9 7.2 3.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Ctr PF04145.10 CDI77872.1 - 8.4 6.4 10.3 13 5.7 0.5 2.5 2 0 0 2 2 2 0 Ctr copper transporter family DUF2201_N PF13203.1 CDI77872.1 - 8.4 5.4 26.4 0.049 12.7 1.2 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain TFIIA PF03153.8 CDI77872.1 - 9.3 6.0 35.0 5.2 6.8 11.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.4 CDI77873.1 - 0.0042 16.6 20.4 0.0042 16.6 14.1 6.1 3 1 2 6 6 6 2 Nuclear RNA-splicing-associated protein Ycf1 PF05758.7 CDI77874.1 - 0.12 10.0 7.1 0.17 9.5 4.9 1.4 1 0 0 1 1 1 0 Ycf1 LMBR1 PF04791.11 CDI77874.1 - 0.78 8.2 3.6 5.2 5.5 3.5 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein Lipase_3 PF01764.20 CDI77875.1 - 0.0029 17.2 0.0 0.0029 17.2 0.0 2.4 3 0 0 3 3 3 1 Lipase (class 3) Phage_DsbA PF11126.3 CDI77875.1 - 9.6 6.3 8.4 0.18 11.9 0.1 2.4 2 0 0 2 2 2 0 Transcriptional regulator DsbA DUF605 PF04652.11 CDI77876.1 - 1.2 8.4 12.6 1.5 8.1 8.8 1.3 1 0 0 1 1 1 0 Vta1 like Cpn10 PF00166.16 CDI77882.1 - 1.9e-39 133.5 0.5 1.9e-18 66.1 0.0 2.1 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit Cupin_3 PF05899.7 CDI77882.1 - 0.002 17.4 0.3 0.21 11.0 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Baseplate_J PF04865.9 CDI77882.1 - 0.02 14.2 0.1 0.03 13.6 0.1 1.4 1 0 0 1 1 1 0 Baseplate J-like protein Na_H_Exchanger PF00999.16 CDI77883.1 - 1.8e-42 145.2 40.5 2.7e-42 144.6 28.1 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Neur_chan_memb PF02932.11 CDI77883.1 - 0.031 14.1 1.3 0.11 12.3 0.0 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RSN1_TM PF13967.1 CDI77884.1 - 0.025 14.1 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport DUF3357 PF11837.3 CDI77884.1 - 0.061 13.1 0.3 0.28 11.0 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) MFS_1 PF07690.11 CDI77884.1 - 0.091 11.4 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily SKG6 PF08693.5 CDI77884.1 - 0.44 9.8 3.7 0.22 10.8 0.7 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain OAD_gamma PF04277.8 CDI77884.1 - 4.2 7.8 5.7 21 5.5 3.8 2.1 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain EST1 PF10374.4 CDI77886.1 - 0.1 12.6 2.1 0.12 12.3 0.0 2.0 2 1 0 2 2 2 0 Telomerase activating protein Est1 TPR_14 PF13428.1 CDI77888.1 - 0.0052 17.3 1.2 16 6.4 0.7 3.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.9 CDI77888.1 - 0.041 14.3 5.5 0.37 11.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.4 CDI77888.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.5 1 1 0 1 1 1 0 26S proteasome subunit RPN7 Jun PF03957.8 CDI77888.1 - 0.3 10.7 1.9 0.28 10.9 0.5 1.5 2 0 0 2 2 2 0 Jun-like transcription factor TPR_2 PF07719.12 CDI77888.1 - 0.56 10.2 2.5 6.6 6.9 0.0 3.2 3 1 2 5 5 5 0 Tetratricopeptide repeat Dehydrin PF00257.14 CDI77891.1 - 0.0018 18.6 2.1 0.0018 18.6 1.5 3.8 4 0 0 4 4 4 2 Dehydrin DUF3413 PF11893.3 CDI77891.1 - 0.2 10.5 1.1 0.5 9.2 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) GRIP PF01465.15 CDI77892.1 - 8.3e-11 41.2 1.5 8.3e-11 41.2 1.1 2.8 3 0 0 3 3 3 1 GRIP domain Stk19 PF10494.4 CDI77893.1 - 1.3e-07 31.2 0.4 1.3e-07 31.2 0.3 2.1 2 0 0 2 2 2 1 Serine-threonine protein kinase 19 DUF755 PF05501.6 CDI77893.1 - 0.00089 19.3 21.2 0.00089 19.3 14.7 8.0 6 3 3 9 9 9 2 Domain of unknown function (DUF755) Pol_alpha_B_N PF08418.5 CDI77893.1 - 0.0042 16.6 3.2 0.0042 16.6 2.2 3.9 4 0 0 4 4 4 1 DNA polymerase alpha subunit B N-terminal LMBR1 PF04791.11 CDI77893.1 - 2.5 6.6 10.9 4.5 5.7 7.6 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Cwf_Cwc_15 PF04889.7 CDI77893.1 - 6.1 6.4 64.8 0.48 10.0 28.5 3.6 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Herpes_UL87 PF03043.9 CDI77893.1 - 6.3 5.0 22.7 6.1 5.1 1.4 2.9 1 1 0 2 2 2 0 Herpesvirus UL87 family Lip_prot_lig_C PF10437.4 CDI77896.1 - 4.7e-05 22.9 0.0 0.00016 21.3 0.0 1.9 2 0 0 2 2 2 1 Bacterial lipoate protein ligase C-terminus Condensation PF00668.15 CDI77896.1 - 0.026 13.3 1.4 0.43 9.3 0.4 2.0 2 0 0 2 2 2 0 Condensation domain RNA_pol_Rbc25 PF08292.7 CDI77896.1 - 0.09 12.9 0.7 9.4 6.4 0.9 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Gag_p17 PF00540.13 CDI77896.1 - 0.15 11.7 1.4 0.22 11.2 1.0 1.2 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) U1snRNP70_N PF12220.3 CDI77896.1 - 0.37 11.1 6.1 0.57 10.5 4.2 1.2 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SR-25 PF10500.4 CDI77897.1 - 0.0083 15.6 18.2 0.0083 15.6 12.6 4.1 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Pkinase PF00069.20 CDI77900.1 - 0.00019 20.6 0.0 0.00032 19.9 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77900.1 - 0.00041 19.5 0.1 0.00067 18.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase MdcG PF10620.4 CDI77900.1 - 0.021 14.3 1.0 0.038 13.5 0.7 1.6 1 1 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG DUF2457 PF10446.4 CDI77901.1 - 0.00019 20.3 14.5 0.00022 20.0 10.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) TLP-20 PF06088.6 CDI77901.1 - 0.005 16.5 11.3 0.0097 15.5 7.8 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) FimP PF09766.4 CDI77901.1 - 0.072 12.1 15.9 0.098 11.7 11.0 1.2 1 0 0 1 1 1 0 Fms-interacting protein Sporozoite_P67 PF05642.6 CDI77901.1 - 0.14 9.9 12.1 0.16 9.8 8.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CobT PF06213.7 CDI77901.1 - 0.23 10.5 17.6 0.31 10.1 12.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 CDI77901.1 - 0.25 9.2 20.8 0.25 9.2 14.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 CDI77901.1 - 0.3 9.0 19.6 0.32 8.9 13.6 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.7 CDI77901.1 - 0.54 9.4 16.0 0.72 9.0 11.1 1.3 1 0 0 1 1 1 0 NOA36 protein Daxx PF03344.10 CDI77901.1 - 0.64 8.4 23.9 0.68 8.3 16.5 1.1 1 0 0 1 1 1 0 Daxx Family Zip PF02535.17 CDI77901.1 - 1 8.2 9.1 1.1 8.1 6.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Striatin PF08232.7 CDI77901.1 - 4.1 7.7 14.7 6.4 7.0 10.0 1.5 1 1 0 1 1 1 0 Striatin family Cwf_Cwc_15 PF04889.7 CDI77901.1 - 4.3 6.9 27.6 2.4 7.8 18.0 1.4 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Prog_receptor PF02161.10 CDI77901.1 - 4.4 6.0 8.2 5 5.8 5.7 1.2 1 0 0 1 1 1 0 Progesterone receptor Med19 PF10278.4 CDI77901.1 - 5.8 6.5 15.5 7.7 6.1 10.7 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DNA_pol_phi PF04931.8 CDI77901.1 - 5.8 4.5 15.7 5.7 4.5 10.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.11 CDI77901.1 - 8.3 5.3 13.6 12 4.7 9.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MFS_1 PF07690.11 CDI77902.1 - 1.1e-09 37.4 24.1 1.8e-07 30.2 17.6 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF106 PF01956.11 CDI77902.1 - 0.0078 15.7 0.2 0.45 10.0 0.0 2.5 2 0 0 2 2 2 1 Integral membrane protein DUF106 Ycf1 PF05758.7 CDI77902.1 - 0.038 11.7 0.0 0.054 11.2 0.0 1.1 1 0 0 1 1 1 0 Ycf1 Carb_anhydrase PF00194.16 CDI77903.1 - 1.9e-12 46.6 1.3 1.1e-09 37.6 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic-type carbonic anhydrase DUF387 PF04079.11 CDI77903.1 - 0.0055 16.0 0.1 0.024 14.0 0.0 1.9 2 0 0 2 2 2 1 Putative transcriptional regulators (Ypuh-like) SET PF00856.23 CDI77904.1 - 0.033 14.4 0.9 0.25 11.6 0.0 2.8 3 0 0 3 3 3 0 SET domain Rep_fac-A_3 PF08661.6 CDI77905.1 - 2.8e-11 43.2 0.0 3.2e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 tRNA_Me_trans PF03054.11 CDI77906.1 - 1.7e-76 257.0 0.0 3.5e-69 233.0 0.0 2.4 2 0 0 2 2 2 2 tRNA methyl transferase ThiI PF02568.9 CDI77906.1 - 0.0073 15.7 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.16 CDI77906.1 - 0.059 12.8 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Asparagine synthase Methyltransf_3 PF01596.12 CDI77907.1 - 9.2e-20 70.5 0.0 2.4e-10 39.7 0.0 2.9 2 1 0 2 2 2 2 O-methyltransferase Rhodanese PF00581.15 CDI77907.1 - 1.2e-12 48.1 0.0 3.3e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_24 PF13578.1 CDI77907.1 - 1.9e-07 31.8 0.0 6e-07 30.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI77907.1 - 0.0013 18.7 0.0 0.0036 17.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI77907.1 - 0.005 17.4 0.0 0.012 16.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain RCC1_2 PF13540.1 CDI77909.1 - 3.1e-06 26.6 8.2 0.39 10.4 0.1 5.2 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat BAF1_ABF1 PF04684.8 CDI77909.1 - 0.13 11.0 30.4 0.2 10.4 21.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CENP-U PF13097.1 CDI77909.1 - 0.23 11.3 12.4 0.43 10.5 8.6 1.3 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit Ycf1 PF05758.7 CDI77909.1 - 0.51 7.9 6.1 0.62 7.7 4.2 1.1 1 0 0 1 1 1 0 Ycf1 PBP1_TM PF14812.1 CDI77909.1 - 0.85 9.9 4.4 1.5 9.2 3.1 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pex14_N PF04695.8 CDI77909.1 - 1.5 8.8 14.0 3.3 7.7 9.7 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RP-C_C PF11800.3 CDI77909.1 - 1.9 8.1 9.9 2.9 7.5 6.9 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.17 CDI77909.1 - 2 7.3 8.9 3.1 6.6 6.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RCC1 PF00415.13 CDI77909.1 - 2.8 8.1 6.0 22 5.3 0.5 3.3 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Spore_YhcN_YlaJ PF09580.5 CDI77909.1 - 3.7 7.6 15.9 5.7 7.0 11.0 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AIF_C PF14721.1 CDI77909.1 - 3.9 7.7 7.4 8 6.7 5.1 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4557 PF15101.1 CDI77909.1 - 5 6.9 17.6 8.6 6.1 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Rtf2 PF04641.7 CDI77909.1 - 5.4 6.1 14.0 48 3.0 0.0 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger Borrelia_P83 PF05262.6 CDI77909.1 - 6 5.0 18.6 8.5 4.5 12.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PAT1 PF09770.4 CDI77909.1 - 7.5 4.6 26.0 11 4.0 18.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sporozoite_P67 PF05642.6 CDI77911.1 - 0.0002 19.4 12.5 0.0002 19.4 8.7 12.3 4 3 1 7 7 7 2 Sporozoite P67 surface antigen NTP_transf_2 PF01909.18 CDI77911.1 - 5.5 7.3 0.0 10 6.5 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase domain BAF1_ABF1 PF04684.8 CDI77913.1 - 0.035 12.9 5.0 0.046 12.5 3.5 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDK2AP PF09806.4 CDI77913.1 - 0.52 10.5 6.3 0.62 10.2 4.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Ribosomal_60s PF00428.14 CDI77913.1 - 0.97 9.8 7.1 1.5 9.3 4.9 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein APG6 PF04111.7 CDI77914.1 - 0.00092 18.3 6.7 0.00092 18.3 4.7 3.1 3 0 0 3 3 3 1 Autophagy protein Apg6 DUF4446 PF14584.1 CDI77914.1 - 0.026 14.3 0.4 0.026 14.3 0.3 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4446) Macoilin PF09726.4 CDI77914.1 - 4.9 5.3 42.9 4.5 5.4 12.7 2.4 2 0 0 2 2 2 0 Transmembrane protein Mucin PF01456.12 CDI77915.1 - 0.00012 21.8 10.8 0.00012 21.8 7.5 4.9 3 2 0 3 3 3 1 Mucin-like glycoprotein Dehydrin PF00257.14 CDI77915.1 - 0.037 14.3 0.6 0.21 11.8 0.4 2.5 1 1 0 1 1 1 0 Dehydrin Ribosomal_60s PF00428.14 CDI77918.1 - 0.041 14.2 0.8 0.041 14.2 0.6 13.0 2 1 5 7 7 7 0 60s Acidic ribosomal protein Ofd1_CTDD PF10637.4 CDI77918.1 - 1.8 7.6 5.7 2.8 7.0 4.0 1.2 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Kazal_2 PF07648.10 CDI77919.1 - 9.5e-07 28.6 1.7 9.5e-07 28.6 1.2 3.7 4 0 0 4 4 4 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.16 CDI77919.1 - 7.1e-06 25.9 3.3 2.4e-05 24.2 1.2 2.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain DUF3439 PF11921.3 CDI77919.1 - 0.0014 18.3 12.6 0.0018 18.0 6.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) CAML PF14963.1 CDI77920.1 - 7.6e-05 22.2 0.2 0.22 10.8 0.0 2.2 2 0 0 2 2 2 2 Calcium signal-modulating cyclophilin ligand Synaptobrevin PF00957.16 CDI77921.1 - 2.7e-20 71.7 2.2 5e-19 67.6 1.5 2.1 1 1 0 1 1 1 1 Synaptobrevin Longin PF13774.1 CDI77921.1 - 4.7e-20 70.9 0.0 7.5e-20 70.2 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_UL49_5 PF05702.6 CDI77923.1 - 0.022 14.6 0.0 0.055 13.3 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL49.5 envelope/tegument protein B PF02216.11 CDI77925.1 - 0.032 13.9 1.6 0.66 9.7 0.0 2.4 2 0 0 2 2 2 0 B domain DUF3131 PF11329.3 CDI77925.1 - 0.078 11.6 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3131) PAT1 PF09770.4 CDI77928.1 - 0.0011 17.3 54.8 0.0012 17.2 38.0 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 AvrE PF11725.3 CDI77928.1 - 0.026 11.6 21.2 0.032 11.2 14.7 1.0 1 0 0 1 1 1 0 Pathogenicity factor Herpes_DNAp_acc PF04929.7 CDI77928.1 - 1 8.2 19.7 1.3 7.8 13.6 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Zip PF02535.17 CDI77928.1 - 1.4 7.8 9.2 2 7.3 6.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter eIF-3_zeta PF05091.7 CDI77928.1 - 1.4 7.4 24.5 2.2 6.8 17.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GAGA_bind PF06217.7 CDI77928.1 - 4.7 7.0 24.8 2.6 7.9 16.0 1.4 2 0 0 2 2 2 0 GAGA binding protein-like family DUF3959 PF13105.1 CDI77928.1 - 6.9 5.9 10.1 9.8 5.4 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Hid1 PF12722.2 CDI77928.1 - 7.4 4.1 24.1 8.8 3.8 16.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mem_trans PF03547.13 CDI77928.1 - 8.4 4.5 7.8 13 3.9 5.4 1.3 1 0 0 1 1 1 0 Membrane transport protein DUF4045 PF13254.1 CDI77928.1 - 9.8 5.3 20.7 16 4.6 14.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Aminotran_5 PF00266.14 CDI77929.1 - 2.2e-13 49.7 10.2 0.0025 16.5 0.7 5.4 5 0 0 5 5 5 4 Aminotransferase class-V ATP_bind_3 PF01171.15 CDI77929.1 - 6.5e-08 32.2 0.1 6.5e-08 32.2 0.0 2.5 3 0 0 3 3 3 1 PP-loop family SR-25 PF10500.4 CDI77929.1 - 1.5e-05 24.5 32.0 1.5e-05 24.5 22.2 11.7 10 4 2 12 12 12 3 Nuclear RNA-splicing-associated protein AAA_23 PF13476.1 CDI77929.1 - 1.9 8.7 42.8 0.34 11.2 1.3 5.4 5 0 0 5 5 5 0 AAA domain GTP1_OBG PF01018.17 CDI77930.1 - 8.2e-13 48.2 0.9 8.2e-13 48.2 0.6 2.5 2 2 1 3 3 3 1 GTP1/OBG MMR_HSR1 PF01926.18 CDI77930.1 - 3.2e-12 46.4 0.0 2e-11 43.8 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CDI77930.1 - 0.003 17.3 13.9 0.038 13.8 9.6 2.5 1 1 0 1 1 1 1 Dynamin family AAA_21 PF13304.1 CDI77930.1 - 0.029 14.3 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 CDI77930.1 - 0.054 13.9 0.0 0.054 13.9 0.0 2.8 1 1 0 2 2 2 0 Miro-like protein FeoB_N PF02421.13 CDI77930.1 - 0.057 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDI77930.1 - 0.65 9.3 7.5 2.2 7.7 0.0 3.3 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_23 PF13476.1 CDI77930.1 - 0.97 9.7 0.0 0.97 9.7 0.0 3.4 3 1 0 3 3 3 0 AAA domain SOBP PF15279.1 CDI77930.1 - 6.9 6.9 37.9 9 6.5 14.7 2.5 2 0 0 2 2 2 0 Sine oculis-binding protein DUF515 PF04415.7 CDI77931.1 - 7.2 4.7 12.1 20 3.2 8.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF515) CRAL_TRIO PF00650.15 CDI77932.1 - 2.7e-12 46.4 0.1 3.5e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain TFIIA PF03153.8 CDI77932.1 - 0.13 12.1 12.1 0.18 11.6 8.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Kinase-like PF14531.1 CDI77933.1 - 2.2e-09 36.7 0.0 3.4e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.20 CDI77933.1 - 8.8e-09 34.8 0.0 1.9e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77933.1 - 0.00077 18.6 0.0 0.0014 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Tubulin PF00091.20 CDI77934.1 - 9.9e-71 237.9 0.0 1.6e-70 237.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CDI77934.1 - 3.5e-49 166.0 0.1 5.3e-49 165.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 CDI77934.1 - 9.7e-05 22.4 0.0 0.00023 21.2 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 CDI77934.1 - 0.0071 15.8 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain COX14 PF14880.1 CDI77935.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.7 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF202 PF02656.10 CDI77935.1 - 1 9.5 5.1 0.24 11.6 0.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Vac_Fusion PF02346.11 CDI77936.1 - 0.026 13.9 0.1 0.08 12.3 0.1 1.8 1 0 0 1 1 1 0 Chordopoxvirus fusion protein Hydrolase PF00702.21 CDI77937.1 - 0.0025 18.2 0.0 0.0032 17.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CDI77937.1 - 0.006 16.8 0.0 0.98 9.6 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase DUF3639 PF12341.3 CDI77938.1 - 4.4e-05 23.3 0.2 4.4e-05 23.3 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3639) GTP_cyclohydroI PF01227.17 CDI77938.1 - 0.11 11.7 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase I LRR_8 PF13855.1 CDI77939.1 - 1.5e-10 40.6 0.1 1.3e-08 34.4 0.0 2.6 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 CDI77939.1 - 3.5e-08 32.8 0.0 0.0026 17.3 0.0 4.4 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 CDI77939.1 - 0.0055 16.6 0.0 68 4.0 0.0 5.2 5 0 0 5 5 5 0 Leucine Rich repeat F-box-like_2 PF13013.1 CDI77939.1 - 0.02 14.5 0.1 0.29 10.8 0.0 2.4 2 1 0 2 2 2 0 F-box-like domain adh_short PF00106.20 CDI77940.1 - 1.7e-11 44.3 3.1 3.2e-11 43.4 2.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDI77940.1 - 3.4e-08 33.3 0.7 6.1e-08 32.5 0.4 1.4 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 CDI77940.1 - 0.0026 17.5 0.2 0.0067 16.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 CDI77940.1 - 0.014 15.4 0.7 0.02 14.9 0.4 1.4 1 1 0 1 1 1 0 NADH(P)-binding Methyltransf_19 PF04672.7 CDI77940.1 - 0.022 14.0 0.1 0.028 13.6 0.1 1.2 1 0 0 1 1 1 0 S-adenosyl methyltransferase Polysacc_synt_2 PF02719.10 CDI77940.1 - 0.042 12.7 0.0 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.16 CDI77940.1 - 0.044 13.1 0.1 0.054 12.9 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF4191 PF13829.1 CDI77940.1 - 0.078 12.0 1.1 0.12 11.5 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) adh_short_C2 PF13561.1 CDI77940.1 - 0.094 12.4 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DUF1469 PF07332.6 CDI77940.1 - 0.97 9.1 4.0 3 7.6 2.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) UBA_4 PF14555.1 CDI77943.1 - 6.9e-07 28.6 0.0 1.2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.1 CDI77943.1 - 0.00042 20.2 0.1 0.001 19.0 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like ABC_membrane PF00664.18 CDI77944.1 - 2.6e-67 227.1 3.3 4.1e-42 144.4 0.5 2.9 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CDI77944.1 - 1.4e-48 164.6 0.0 6.9e-34 117.0 0.0 3.3 2 1 0 2 2 2 2 ABC transporter AAA_16 PF13191.1 CDI77944.1 - 2.9e-10 40.4 1.1 0.00078 19.4 0.2 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 CDI77944.1 - 3.2e-08 32.9 0.0 0.009 15.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 CDI77944.1 - 3.5e-08 34.2 0.1 0.014 16.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CDI77944.1 - 3.7e-08 32.7 0.0 0.0091 15.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_28 PF13521.1 CDI77944.1 - 4.1e-08 33.3 0.1 0.0044 17.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.1 CDI77944.1 - 7.1e-08 32.7 0.0 0.49 10.3 0.0 3.3 2 1 1 3 3 3 3 AAA domain AAA_22 PF13401.1 CDI77944.1 - 1.6e-07 31.5 0.7 0.0049 17.0 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CDI77944.1 - 1.9e-07 30.6 0.0 0.16 11.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.1 CDI77944.1 - 1.3e-06 28.1 0.1 0.0019 17.7 0.0 3.1 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.14 CDI77944.1 - 2.3e-06 27.0 0.9 0.0013 17.9 0.0 3.1 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA PF00004.24 CDI77944.1 - 4.1e-06 27.0 0.0 0.0039 17.3 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI77944.1 - 1.3e-05 24.9 0.1 0.094 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CDI77944.1 - 0.00019 21.7 0.3 0.7 10.2 0.1 2.6 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.17 CDI77944.1 - 0.00023 20.1 0.0 0.074 11.8 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_14 PF13173.1 CDI77944.1 - 0.00032 20.5 0.2 0.96 9.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain ATP-synt_ab PF00006.20 CDI77944.1 - 0.00042 19.8 0.0 0.93 8.9 0.0 2.4 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ABC_ATPase PF09818.4 CDI77944.1 - 0.00052 18.7 0.0 0.035 12.6 0.0 2.6 3 0 0 3 3 3 1 Predicted ATPase of the ABC class G-alpha PF00503.15 CDI77944.1 - 0.0007 18.3 0.0 0.83 8.2 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_33 PF13671.1 CDI77944.1 - 0.0022 17.8 0.0 1 9.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 CDI77944.1 - 0.0022 17.5 0.2 1.5 8.3 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Miro PF08477.8 CDI77944.1 - 0.0026 18.2 0.3 3.6 8.1 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein RNA_helicase PF00910.17 CDI77944.1 - 0.0044 17.1 0.1 3.6 7.7 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Viral_helicase1 PF01443.13 CDI77944.1 - 0.0068 15.9 1.0 2.3 7.6 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.18 CDI77944.1 - 0.0073 16.2 0.1 7.4 6.5 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF815 PF05673.8 CDI77944.1 - 0.0089 14.9 0.0 2 7.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.10 CDI77944.1 - 0.01 14.5 0.3 1.8 7.1 0.1 2.1 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Zeta_toxin PF06414.7 CDI77944.1 - 0.012 14.7 0.0 1.4 8.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.1 CDI77944.1 - 0.012 15.8 0.0 7.4 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 CDI77944.1 - 0.015 15.0 1.1 2.5 7.7 0.4 3.1 2 1 0 2 2 2 0 NTPase PduV-EutP PF10662.4 CDI77944.1 - 0.015 14.7 0.5 5.8 6.3 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.1 CDI77944.1 - 0.017 14.1 0.0 2.8 6.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.13 CDI77944.1 - 0.019 14.2 0.1 2.1 7.6 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B NACHT PF05729.7 CDI77944.1 - 0.019 14.6 1.9 4.1 7.0 0.1 2.9 3 0 0 3 3 3 0 NACHT domain Guanylate_kin PF00625.16 CDI77944.1 - 0.038 13.4 0.1 2.5 7.5 0.0 2.7 3 0 0 3 3 2 0 Guanylate kinase FtsK_SpoIIIE PF01580.13 CDI77944.1 - 0.043 13.2 0.0 2.9 7.3 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF2138 PF09909.4 CDI77944.1 - 0.053 11.6 0.1 0.082 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2138) IstB_IS21 PF01695.12 CDI77944.1 - 0.055 12.8 0.5 7.3 5.9 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein SbcCD_C PF13558.1 CDI77944.1 - 0.066 13.1 0.2 0.43 10.5 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit CoaE PF01121.15 CDI77944.1 - 0.074 12.4 0.1 2.5 7.4 0.0 2.4 2 0 0 2 2 2 0 Dephospho-CoA kinase Ras PF00071.17 CDI77944.1 - 0.087 12.2 0.3 12 5.3 0.0 2.4 2 0 0 2 2 2 0 Ras family KaiC PF06745.8 CDI77944.1 - 0.12 11.5 1.8 5.9 5.9 0.0 2.6 3 0 0 3 3 2 0 KaiC AAA_10 PF12846.2 CDI77944.1 - 0.14 11.5 0.7 26 4.0 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain FimP PF09766.4 CDI77945.1 - 0.0013 17.8 6.6 0.0013 17.8 4.6 8.6 7 1 1 8 8 8 5 Fms-interacting protein zf-RING_UBOX PF13445.1 CDI77947.1 - 4.2e-06 26.3 3.4 1.9e-05 24.2 2.3 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 CDI77947.1 - 4.4e-05 23.2 6.9 4.4e-05 23.2 4.8 3.3 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.1 CDI77947.1 - 0.00029 20.4 5.8 0.00029 20.4 4.0 3.4 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDI77947.1 - 0.0025 17.4 5.8 0.0025 17.4 4.0 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI77947.1 - 0.012 15.6 7.3 0.012 15.6 5.0 3.2 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) BRCT PF00533.21 CDI77949.1 - 2.3e-11 43.6 0.0 4.9e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-met PF12874.2 CDI77950.1 - 0.1 12.8 0.4 0.22 11.8 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CDI77950.1 - 0.37 11.0 1.5 0.71 10.0 1.0 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Kelch_6 PF13964.1 CDI77951.1 - 2e-10 40.3 3.8 0.0017 18.4 0.0 5.0 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 CDI77951.1 - 2.1e-08 33.5 0.8 0.0001 21.7 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 CDI77951.1 - 1e-07 31.7 3.0 0.015 15.2 0.3 4.6 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.1 CDI77951.1 - 1.5e-07 31.0 10.8 0.011 15.4 0.7 5.5 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 CDI77951.1 - 3.5e-05 23.3 8.8 0.00019 21.0 0.0 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.1 CDI77951.1 - 9.8e-05 22.4 0.1 9.8e-05 22.4 0.1 6.2 7 1 0 7 7 7 1 Galactose oxidase, central domain RNase_T PF00929.19 CDI77953.1 - 0.02 15.2 0.1 0.031 14.5 0.1 1.3 1 0 0 1 1 1 0 Exonuclease AT_hook PF02178.14 CDI77953.1 - 0.083 12.6 1.5 0.23 11.2 1.1 1.8 1 0 0 1 1 1 0 AT hook motif DUF972 PF06156.8 CDI77953.1 - 0.82 10.0 5.1 0.31 11.4 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) WD40 PF00400.27 CDI77956.1 - 2.2e-13 49.4 0.7 2e-06 27.4 0.1 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Ribosomal_60s PF00428.14 CDI77956.1 - 0.051 13.9 8.7 1.1 9.6 0.1 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF4357 PF14267.1 CDI77956.1 - 0.82 9.3 6.3 0.64 9.6 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) HECT PF00632.20 CDI77957.1 - 6.9e-48 163.4 0.0 3.2e-47 161.2 0.0 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.1 CDI77957.1 - 2e-09 37.8 0.0 6.2e-09 36.2 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Macoilin PF09726.4 CDI77957.1 - 6.2e-08 31.4 0.1 6.2e-08 31.4 0.1 4.6 3 2 2 5 5 5 1 Transmembrane protein Ins_P5_2-kin PF06090.7 CDI77958.1 - 0.75 8.7 1.8 0.87 8.5 0.1 1.7 2 0 0 2 2 2 0 Inositol-pentakisphosphate 2-kinase PAT1 PF09770.4 CDI77959.1 - 0.001 17.4 58.9 0.001 17.4 40.8 6.2 3 2 2 6 6 6 2 Topoisomerase II-associated protein PAT1 DUF2749 PF10907.3 CDI77961.1 - 0.96 9.3 8.2 5 7.0 0.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2749) Macoilin PF09726.4 CDI77961.1 - 1.3 7.2 21.0 1.6 6.8 14.5 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF2217 PF10265.4 CDI77961.1 - 1.9 7.1 13.6 2.2 6.9 9.5 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) FAM196 PF15265.1 CDI77961.1 - 3.7 6.6 18.9 4.5 6.4 13.1 1.0 1 0 0 1 1 1 0 FAM196 family Condensin2nSMC PF12422.3 CDI77966.1 - 0.048 13.4 0.9 0.079 12.7 0.7 1.3 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit Sec23_trunk PF04811.10 CDI77966.1 - 1.4 8.2 9.6 2.1 7.6 6.7 1.3 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain AAA_23 PF13476.1 CDI77966.1 - 6.1 7.1 17.6 7.7 6.7 12.2 1.2 1 0 0 1 1 1 0 AAA domain Phage_GPO PF05929.6 CDI77966.1 - 9.6 5.3 14.1 15 4.7 9.8 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Hexokinase_1 PF00349.16 CDI77967.1 - 1.7e-16 60.1 0.0 2.1e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 CDI77967.1 - 4.2e-07 29.4 0.1 5.5e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Alpha-amylase PF00128.19 CDI77969.1 - 9.1e-17 61.4 0.0 1.1e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DegT_DnrJ_EryC1 PF01041.12 CDI77969.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_60s PF00428.14 CDI77969.1 - 0.6 10.5 3.7 3.4 8.1 2.0 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein RRM_1 PF00076.17 CDI77972.1 - 2e-25 88.1 0.0 5.4e-16 57.9 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI77972.1 - 4e-23 81.1 0.0 2.3e-11 43.4 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI77972.1 - 5.9e-12 45.2 0.0 0.0008 19.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRTase_1 PF11202.3 CDI77974.1 - 0.007 15.3 0.1 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase (PRTase) NAD_binding_1 PF00175.16 CDI77975.1 - 3e-17 63.1 0.0 4.5e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CDI77975.1 - 0.002 18.2 0.0 0.0044 17.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Pkinase PF00069.20 CDI77976.1 - 5.1e-62 209.3 0.1 5.7e-61 205.9 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI77976.1 - 4.4e-27 94.7 4.4 7.6e-19 67.7 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Dehydrin PF00257.14 CDI77976.1 - 0.0011 19.3 15.2 0.1 12.9 9.4 2.9 2 0 0 2 2 2 1 Dehydrin Kinase-like PF14531.1 CDI77976.1 - 0.0022 17.0 0.0 2.2 7.1 0.0 3.2 3 0 0 3 3 3 2 Kinase-like Draxin PF15550.1 CDI77976.1 - 0.0081 15.8 12.6 0.0099 15.5 7.5 2.1 2 0 0 2 2 2 1 Draxin HlyD_2 PF12700.2 CDI77976.1 - 1.2 8.2 11.9 2.1 7.4 8.3 1.3 1 0 0 1 1 1 0 HlyD family secretion protein WD40 PF00400.27 CDI77978.1 - 0.0069 16.2 0.3 0.047 13.6 0.3 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF2722 PF10846.3 CDI77978.1 - 0.02 13.9 0.4 10 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Pex14_N PF04695.8 CDI77978.1 - 0.056 13.4 4.4 14 5.7 0.1 4.0 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3371 PF11851.3 CDI77978.1 - 1 10.0 10.7 3.3 8.4 0.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3371) ACDC PF14733.1 CDI77980.1 - 5.8e-07 29.5 0.0 0.0051 16.9 0.0 2.8 3 0 0 3 3 3 2 AP2-coincident C-terminal Sporozoite_P67 PF05642.6 CDI77980.1 - 4.3e-05 21.6 16.5 4.3e-05 21.6 11.5 2.8 3 0 0 3 3 3 1 Sporozoite P67 surface antigen Herpes_capsid PF06112.6 CDI77980.1 - 0.0031 17.5 16.4 0.0031 17.5 11.4 7.5 6 2 1 7 7 7 1 Gammaherpesvirus capsid protein MAP65_ASE1 PF03999.7 CDI77980.1 - 2.8 6.4 10.6 6.6 5.2 7.3 1.6 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) AAA_23 PF13476.1 CDI77981.1 - 0.014 15.7 2.7 0.019 15.2 1.9 1.2 1 0 0 1 1 1 0 AAA domain Med15 PF09606.5 CDI77981.1 - 0.05 11.8 35.3 0.058 11.5 24.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal YPEB PF14620.1 CDI77981.1 - 0.16 10.9 6.1 0.25 10.3 4.2 1.2 1 0 0 1 1 1 0 YpeB sporulation DUF812 PF05667.6 CDI77981.1 - 0.17 10.3 8.8 0.22 9.9 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF3373 PF11853.3 CDI77981.1 - 0.51 8.8 3.3 0.79 8.1 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) OmpH PF03938.9 CDI77981.1 - 0.77 9.6 18.1 1.4 8.8 12.5 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF342 PF03961.8 CDI77981.1 - 0.96 7.7 3.0 1.3 7.3 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc24 PF08286.6 CDI77981.1 - 1.5 8.5 9.3 2.7 7.7 6.4 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 TFIIA PF03153.8 CDI77981.1 - 9.8 5.9 23.0 17 5.1 15.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CLPTM1 PF05602.7 CDI77982.1 - 3.9e-22 78.5 0.1 5.6e-22 78.0 0.1 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF4604 PF15377.1 CDI77983.1 - 0.35 11.0 27.1 0.81 9.8 3.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4604) Na_trans_assoc PF06512.8 CDI77983.1 - 4.5 7.1 18.2 17 5.3 12.5 1.9 1 1 0 1 1 1 0 Sodium ion transport-associated DARPP-32 PF05395.7 CDI77983.1 - 9.1 6.4 34.5 7 6.7 7.5 2.2 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 HTH_Tnp_IS630 PF01710.11 CDI77986.1 - 0.031 13.9 0.1 0.1 12.2 0.1 1.8 2 0 0 2 2 2 0 Transposase Ribosomal_L17 PF01196.14 CDI77987.1 - 1.2e-19 70.6 0.1 1.8e-19 70.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 AFT PF08731.6 CDI77990.1 - 0.062 13.4 0.8 0.062 13.4 0.5 1.8 2 0 0 2 2 2 0 Transcription factor AFT OSTbeta PF15048.1 CDI77990.1 - 0.22 11.6 0.2 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein CD20 PF04103.10 CDI77990.1 - 0.24 11.3 8.5 0.41 10.5 0.1 2.6 3 0 0 3 3 3 0 CD20-like family Suf PF05843.9 CDI77990.1 - 1.3 8.6 14.7 1.1 8.9 3.9 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Spt20 PF12090.3 CDI77990.1 - 5.6 6.2 11.0 9.8 5.4 0.4 2.2 2 0 0 2 2 2 0 Spt20 family RskA PF10099.4 CDI77990.1 - 9.8 5.8 20.9 1.3 8.7 8.5 2.6 2 1 1 3 3 3 0 Anti-sigma-K factor rskA EF-hand_7 PF13499.1 CDI77992.1 - 2.3e-13 50.0 0.0 2.2e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDI77992.1 - 8.2e-13 46.6 0.0 4.6e-07 28.6 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 CDI77992.1 - 1.8e-11 42.9 0.1 8.6e-06 25.2 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 CDI77992.1 - 1.2e-07 30.7 0.0 0.00014 21.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 CDI77992.1 - 1.1e-06 28.1 0.2 0.15 11.6 0.0 4.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 CDI77992.1 - 0.0031 17.4 0.0 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain TFIIA PF03153.8 CDI77992.1 - 0.0064 16.4 18.6 0.0066 16.3 12.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Excalibur PF05901.6 CDI77992.1 - 0.0074 16.6 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Excalibur calcium-binding domain Ribosomal_60s PF00428.14 CDI77992.1 - 0.045 14.1 13.2 0.53 10.7 3.9 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Slu7 PF11708.3 CDI77992.1 - 0.45 10.2 13.7 0.61 9.7 9.5 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Med15 PF09606.5 CDI77992.1 - 0.52 8.4 37.1 0.7 8.0 25.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal K_channel_TID PF07941.6 CDI77992.1 - 0.55 10.5 12.4 1.2 9.3 2.1 2.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Peptidase_S15 PF02129.13 CDI77992.1 - 3.2 7.1 12.1 4.5 6.5 8.4 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Selenoprotein_S PF06936.6 CDI77992.1 - 4.6 6.7 13.5 7.1 6.1 9.4 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) PAT1 PF09770.4 CDI77992.1 - 4.9 5.2 32.7 6.2 4.9 22.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Shadoo PF14999.1 CDI77992.1 - 8.9 6.1 8.9 33 4.3 3.3 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective TMF_TATA_bd PF12325.3 CDI77996.1 - 0.00037 20.2 2.0 0.00073 19.2 1.4 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding FlxA PF14282.1 CDI77996.1 - 0.03 14.2 5.0 0.03 14.2 3.4 2.5 2 0 0 2 2 2 0 FlxA-like protein Lzipper-MIP1 PF14389.1 CDI77996.1 - 0.047 13.7 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 COG5 PF10392.4 CDI77996.1 - 0.052 13.5 0.1 0.07 13.0 0.1 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Peptidase_S64 PF08192.6 CDI77996.1 - 0.088 11.1 11.7 0.098 10.9 8.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.4 CDI77996.1 - 0.27 10.0 7.3 0.32 9.8 5.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AKNA PF12443.3 CDI77996.1 - 0.3 11.1 3.3 0.33 10.9 0.1 2.2 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF3450 PF11932.3 CDI77996.1 - 0.64 9.2 16.5 0.031 13.5 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Lge1 PF11488.3 CDI77996.1 - 1.3 9.2 7.1 2.9 8.1 4.9 1.8 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF966 PF06136.8 CDI77996.1 - 1.5 8.2 18.5 1.8 7.9 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF755 PF05501.6 CDI77996.1 - 2.2 8.3 29.1 3.6 7.6 8.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF1183 PF06682.7 CDI77996.1 - 5.4 6.5 12.8 7.1 6.1 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) SR-25 PF10500.4 CDI77996.1 - 7.3 5.9 41.0 2.9 7.3 10.3 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein ATG16 PF08614.6 CDI77996.1 - 8.4 6.1 14.3 20 4.9 9.9 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Macoilin PF09726.4 CDI77998.1 - 1.3 7.2 6.5 1.6 6.9 4.5 1.2 1 0 0 1 1 1 0 Transmembrane protein Sporozoite_P67 PF05642.6 CDI77998.1 - 2.4 5.8 8.4 3.1 5.5 5.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2620 PF10941.3 CDI77998.1 - 6.8 6.7 9.9 6.8 6.7 6.0 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF2620 Spt20 PF12090.3 CDI77999.1 - 0.27 10.5 13.9 0.4 10.0 0.9 3.1 3 0 0 3 3 3 0 Spt20 family FimP PF09766.4 CDI77999.1 - 2.3 7.2 22.0 1.1 8.2 2.8 2.7 3 0 0 3 3 3 0 Fms-interacting protein Phostensin_N PF13916.1 CDI78000.1 - 0.22 11.5 8.3 4.1 7.4 0.4 3.0 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DUF1049 PF06305.6 CDI78000.1 - 0.7 9.4 5.9 2.4 7.6 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) RVT_1 PF00078.22 CDI78002.1 - 0.0027 17.1 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1049 PF06305.6 CDI78006.1 - 6.4 6.3 7.1 0.73 9.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) BAF1_ABF1 PF04684.8 CDI78007.1 - 0.00021 20.2 7.5 0.00021 20.2 5.2 9.4 7 3 2 9 9 9 2 BAF1 / ABF1 chromatin reorganising factor PAM2 PF07145.10 CDI78007.1 - 0.00042 19.6 1.9 5 6.8 0.0 3.7 3 0 0 3 3 3 2 Ataxin-2 C-terminal region Ycf1 PF05758.7 CDI78007.1 - 0.031 12.0 11.4 0.15 9.7 1.5 2.5 2 0 0 2 2 2 0 Ycf1 DUF3533 PF12051.3 CDI78007.1 - 1.8 7.2 6.0 3.9 6.1 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Herpes_glycop PF01528.11 CDI78007.1 - 6.6 5.3 6.5 4 6.0 1.9 2.3 2 0 0 2 2 2 0 Herpesvirus glycoprotein M ATP_bind_3 PF01171.15 CDI78010.1 - 1.2e-29 103.1 2.5 1.1e-24 86.8 0.3 3.9 2 1 0 2 2 2 2 PP-loop family Hemolysin_N PF12563.3 CDI78010.1 - 0.023 14.1 1.7 0.053 12.9 0.0 2.5 2 0 0 2 2 2 0 Hemolytic toxin N terminal DUF3798 PF12683.2 CDI78010.1 - 0.075 12.1 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) TLD PF07534.11 CDI78011.1 - 3e-21 75.8 0.2 5.9e-21 74.9 0.1 1.4 1 0 0 1 1 1 1 TLD Nucleoplasmin PF03066.10 CDI78011.1 - 0.0097 15.4 1.9 0.025 14.1 1.3 1.6 1 0 0 1 1 1 1 Nucleoplasmin MitMem_reg PF13012.1 CDI78012.1 - 1.3e-33 115.5 0.3 2e-33 114.8 0.2 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 CDI78012.1 - 5e-22 77.7 0.5 1.9e-21 75.9 0.0 2.1 3 0 0 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RNase_H2-Ydr279 PF09468.5 CDI78012.1 - 0.025 13.8 0.4 0.029 13.5 0.3 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Med30 PF11315.3 CDI78012.1 - 0.078 13.1 1.4 0.35 11.0 0.0 2.2 1 1 1 2 2 2 0 Mediator complex subunit 30 Actin PF00022.14 CDI78013.1 - 2.8e-20 72.1 0.0 3.9e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Actin BSP_II PF05432.6 CDI78013.1 - 0.0077 15.5 1.0 0.011 14.9 0.7 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Peptidase_S15 PF02129.13 CDI78013.1 - 0.11 11.8 3.1 0.2 11.0 2.1 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Macoilin PF09726.4 CDI78016.1 - 0.0019 16.6 25.5 0.0021 16.4 17.6 1.0 1 0 0 1 1 1 1 Transmembrane protein MIP-T3 PF10243.4 CDI78016.1 - 0.086 11.2 18.4 0.12 10.7 12.8 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Na_trans_assoc PF06512.8 CDI78016.1 - 0.2 11.6 12.2 0.28 11.1 8.5 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated THRAP3_BCLAF1 PF15440.1 CDI78016.1 - 0.22 10.1 29.5 0.27 9.8 20.4 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family DUF605 PF04652.11 CDI78016.1 - 0.25 10.7 28.6 0.29 10.4 19.8 1.0 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 CDI78016.1 - 0.59 9.9 26.7 0.69 9.7 18.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAP1 PF08601.5 CDI78016.1 - 1.1 8.8 28.7 1.6 8.3 19.9 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Hex_IIIa PF02455.11 CDI78016.1 - 1.1 7.8 9.9 1.6 7.3 6.9 1.3 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) PAT1 PF09770.4 CDI78016.1 - 2.8 6.0 26.6 3.2 5.8 18.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF936 PF06075.7 CDI78016.1 - 3.3 6.5 22.8 4.2 6.1 15.8 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) TATR PF03430.8 CDI78016.1 - 3.6 6.1 13.7 4.5 5.8 9.5 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Ndc1_Nup PF09531.5 CDI78016.1 - 4.7 5.5 17.6 5.8 5.1 12.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ABC_tran_2 PF12848.2 CDI78016.1 - 6.9 6.5 17.2 4.4 7.2 4.3 2.3 2 0 0 2 2 2 0 ABC transporter DUF2922 PF11148.3 CDI78017.1 - 0.016 14.8 0.1 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) Dehydrin PF00257.14 CDI78017.1 - 0.093 13.0 17.7 0.18 12.1 5.5 2.4 1 1 1 2 2 2 0 Dehydrin DUF4199 PF13858.1 CDI78017.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) MACPF PF01823.14 CDI78017.1 - 0.43 10.2 22.3 0.052 13.2 1.0 2.3 2 0 0 2 2 2 0 MAC/Perforin domain Ycf1 PF05758.7 CDI78017.1 - 0.61 7.7 13.4 0.019 12.6 3.0 1.9 1 1 1 2 2 2 0 Ycf1 PIG-P PF08510.7 CDI78017.1 - 0.98 9.0 3.0 2.1 7.9 2.1 1.8 1 1 0 1 1 1 0 PIG-P Tetraspannin PF00335.15 CDI78017.1 - 1.6 7.9 8.2 3.1 7.0 5.7 1.7 1 1 0 1 1 1 0 Tetraspanin family Lzipper-MIP1 PF14389.1 CDI78017.1 - 2 8.5 15.7 0.044 13.8 1.9 2.8 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Neur_chan_memb PF02932.11 CDI78017.1 - 5.1 6.8 14.9 21 4.9 10.3 1.9 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF457 PF04307.9 CDI78018.1 - 0.034 13.4 0.7 0.056 12.7 0.5 1.5 1 1 0 1 1 1 0 Predicted membrane-bound metal-dependent hydrolase (DUF457) HVSL PF09749.4 CDI78019.1 - 4e-15 55.4 11.7 5.1e-14 51.8 4.3 3.8 3 1 0 4 4 4 3 Uncharacterised conserved protein PMI_typeI PF01238.16 CDI78020.1 - 7.3e-44 150.2 23.3 5.4e-23 81.5 5.9 4.4 1 1 2 3 3 3 2 Phosphomannose isomerase type I Cupin_3 PF05899.7 CDI78020.1 - 0.12 11.8 0.0 0.32 10.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Oxidored_q6 PF01058.17 CDI78020.1 - 0.37 10.3 3.3 0.68 9.5 0.0 3.0 3 1 0 3 3 3 0 NADH ubiquinone oxidoreductase, 20 Kd subunit X PF00739.14 CDI78020.1 - 1.3 8.9 5.0 0.55 10.1 0.4 2.4 2 0 0 2 2 2 0 Trans-activation protein X AMP-binding PF00501.23 CDI78021.1 - 0.014 13.8 0.3 0.021 13.2 0.2 1.2 1 0 0 1 1 1 0 AMP-binding enzyme FHIPEP PF00771.15 CDI78021.1 - 0.035 12.4 3.4 0.062 11.6 2.4 1.3 1 0 0 1 1 1 0 FHIPEP family EamA PF00892.15 CDI78021.1 - 0.041 13.9 7.9 0.11 12.5 5.5 1.7 1 0 0 1 1 1 0 EamA-like transporter family PAT1 PF09770.4 CDI78021.1 - 0.057 11.6 26.3 0.076 11.2 18.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI78021.1 - 1.1 7.3 44.4 2.1 6.4 30.8 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Nuc_sug_transp PF04142.10 CDI78021.1 - 5.2 6.1 8.2 0.065 12.3 0.4 1.7 2 0 0 2 2 2 0 Nucleotide-sugar transporter EmrE PF13536.1 CDI78021.1 - 5.4 7.2 13.9 0.29 11.3 4.2 2.7 2 1 1 3 3 3 0 Multidrug resistance efflux transporter Ycf1 PF05758.7 CDI78021.1 - 8.2 3.9 9.9 12 3.4 6.9 1.1 1 0 0 1 1 1 0 Ycf1 PBP_sp32 PF07222.7 CDI78021.1 - 8.3 5.5 21.6 0.47 9.5 11.1 1.8 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Tmemb_9 PF05434.6 CDI78023.1 - 0.12 12.0 1.9 0.17 11.6 1.3 1.1 1 0 0 1 1 1 0 TMEM9 ATP-synt_ab PF00006.20 CDI78026.1 - 1.7e-59 200.9 0.0 2.6e-59 200.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CDI78026.1 - 3.3e-17 62.9 0.5 9.4e-17 61.5 0.4 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CDI78026.1 - 5.8e-09 36.0 0.1 1.2e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3446 PF11928.3 CDI78027.1 - 0.0098 16.0 6.1 0.16 12.1 1.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3446) OHCU_decarbox PF09349.5 CDI78027.1 - 1.2 9.4 8.5 11 6.2 0.1 2.2 1 1 1 2 2 2 0 OHCU decarboxylase YqzE PF14038.1 CDI78028.1 - 3.6 7.4 5.6 18 5.1 0.1 3.8 3 0 0 3 3 3 0 YqzE-like protein Memo PF01875.12 CDI78030.1 - 6.2e-31 107.2 0.0 3.2e-22 78.6 0.0 2.0 1 1 1 2 2 2 2 Memo-like protein ECR1_N PF14382.1 CDI78031.1 - 1.7e-07 30.3 0.1 2.9e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region S1 PF00575.18 CDI78031.1 - 0.16 12.0 0.5 0.34 11.0 0.0 1.9 3 0 0 3 3 3 0 S1 RNA binding domain SR-25 PF10500.4 CDI78031.1 - 1.1 8.7 6.9 1.6 8.1 4.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FLO_LFY PF01698.11 CDI78035.1 - 3.1e-05 23.0 1.2 3.1e-05 23.0 0.8 2.8 3 0 0 3 3 3 2 Floricaula / Leafy protein FimP PF09766.4 CDI78035.1 - 0.0005 19.2 32.8 0.02 14.0 10.7 3.1 3 0 0 3 3 3 3 Fms-interacting protein DUF2052 PF09747.4 CDI78035.1 - 0.23 11.3 24.0 1.1 9.1 7.2 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Rrp15p PF07890.7 CDI78035.1 - 0.28 11.2 23.2 0.024 14.6 3.8 3.5 3 0 0 3 3 3 0 Rrp15p Dala_Dala_lig_N PF01820.16 CDI78035.1 - 0.62 10.3 14.2 0.27 11.5 2.6 3.3 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus DUF1510 PF07423.6 CDI78035.1 - 1.6 8.0 27.2 0.1 11.9 4.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) DUF4557 PF15101.1 CDI78035.1 - 2 8.1 40.9 0.12 12.1 11.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4557) Raftlin PF15250.1 CDI78035.1 - 2.2 6.7 23.4 0.012 14.1 4.9 2.5 3 0 0 3 3 3 0 Raftlin Spore_coat_CotO PF14153.1 CDI78035.1 - 3.6 6.9 38.5 0.093 12.1 8.6 3.6 4 0 0 4 4 4 0 Spore coat protein CotO FAM60A PF15396.1 CDI78036.1 - 2.1 8.0 12.0 2.4 7.8 8.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A FCP1_C PF09309.5 CDI78036.1 - 2.1 7.5 16.8 2.5 7.3 11.6 1.1 1 0 0 1 1 1 0 FCP1, C-terminal Spc7_N PF15402.1 CDI78036.1 - 3 5.7 18.2 3.3 5.6 12.6 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Peptidase_S64 PF08192.6 CDI78036.1 - 3.5 5.8 16.6 3.5 5.8 11.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 Miff PF05644.6 CDI78036.1 - 4.4 6.8 10.4 4.6 6.7 7.2 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff QH-AmDH_gamma PF08992.6 CDI78038.1 - 0.019 14.7 0.1 9 6.1 0.0 2.3 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit GF_recep_IV PF14843.1 CDI78038.1 - 0.23 11.0 9.6 2.1 7.9 0.9 2.3 2 0 0 2 2 2 0 Growth factor receptor domain IV ADK PF00406.17 CDI78039.1 - 5.2e-29 101.0 0.0 2e-13 50.4 0.0 2.6 2 0 0 2 2 2 2 Adenylate kinase EF_TS PF00889.14 CDI78039.1 - 3e-27 95.4 0.7 3.3e-26 91.9 0.5 2.6 1 1 0 1 1 1 1 Elongation factor TS AAA_17 PF13207.1 CDI78039.1 - 4.5e-15 56.5 0.0 1.9e-08 35.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 CDI78039.1 - 0.00018 21.8 0.0 0.044 14.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain Cytidylate_kin2 PF13189.1 CDI78039.1 - 0.001 18.9 0.0 0.84 9.5 0.0 2.7 2 0 0 2 2 2 2 Cytidylate kinase-like family UBA PF00627.26 CDI78039.1 - 0.0011 18.6 0.0 0.0011 18.6 0.0 2.5 3 0 0 3 3 3 1 UBA/TS-N domain AAA_33 PF13671.1 CDI78039.1 - 0.11 12.3 0.1 0.11 12.3 0.1 4.4 5 0 0 5 5 5 0 AAA domain Thymidylate_kin PF02223.12 CDI78039.1 - 0.42 9.9 0.0 0.42 9.9 0.0 3.3 3 1 0 3 3 3 0 Thymidylate kinase USP8_interact PF08941.5 CDI78040.1 - 9e-05 21.8 4.6 0.067 12.5 0.0 3.1 2 1 1 3 3 3 2 USP8 interacting Occludin_ELL PF07303.8 CDI78040.1 - 0.053 14.2 11.7 1.5 9.5 1.0 3.4 1 1 1 3 3 3 0 Occludin homology domain DUF948 PF06103.6 CDI78040.1 - 0.065 13.1 1.6 0.2 11.5 0.2 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Snapin_Pallidin PF14712.1 CDI78040.1 - 0.19 12.0 7.9 0.098 12.9 3.4 2.0 2 0 0 2 2 2 0 Snapin/Pallidin UPF0054 PF02130.12 CDI78040.1 - 0.46 9.7 4.1 0.11 11.7 0.5 1.6 2 0 0 2 2 2 0 Uncharacterized protein family UPF0054 Neur_chan_memb PF02932.11 CDI78040.1 - 0.76 9.6 3.0 1 9.1 2.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FUSC PF04632.7 CDI78040.1 - 1 7.6 5.3 1.3 7.3 3.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Spc7 PF08317.6 CDI78040.1 - 1.8 7.1 19.2 0.12 11.0 5.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein LMBR1 PF04791.11 CDI78040.1 - 4.2 5.8 9.5 18 3.7 6.6 1.8 1 1 0 1 1 1 0 LMBR1-like membrane protein Adeno_PIX PF03955.9 CDI78040.1 - 4.7 7.7 8.8 1 9.8 0.2 3.0 2 1 1 3 3 3 0 Adenovirus hexon-associated protein (IX) Mu-like_Pro PF10123.4 CDI78040.1 - 4.9 6.5 12.9 6.7 6.0 8.7 1.5 1 1 0 1 1 1 0 Mu-like prophage I protein SlyX PF04102.7 CDI78040.1 - 5 7.5 15.2 0.42 11.0 0.3 3.6 4 1 1 5 5 3 0 SlyX DUF2721 PF11026.3 CDI78040.1 - 6.9 6.3 5.9 3 7.4 1.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) Conotoxin PF02950.12 CDI78040.1 - 7.8 7.3 6.1 2.2 9.1 0.3 2.6 2 1 0 2 2 2 0 Conotoxin DUF4578 PF15147.1 CDI78041.1 - 0.046 14.0 3.5 0.079 13.3 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) Borrelia_P83 PF05262.6 CDI78041.1 - 6.4 4.9 14.5 8.5 4.5 10.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Effector_1 PF04518.7 CDI78042.1 - 0.0002 20.5 6.3 0.00023 20.2 3.6 1.5 1 1 1 2 2 2 1 Effector from type III secretion system Spot_14 PF07084.7 CDI78042.1 - 0.028 14.3 4.4 0.042 13.7 3.1 1.3 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 DUF1993 PF09351.5 CDI78042.1 - 0.031 14.2 4.9 0.043 13.7 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) BRICHOS PF04089.9 CDI78042.1 - 0.079 12.8 0.6 0.21 11.4 0.2 2.0 1 1 1 2 2 2 0 BRICHOS domain DUF3584 PF12128.3 CDI78042.1 - 0.18 9.1 19.4 0.22 8.8 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 CDI78042.1 - 0.3 10.2 2.5 0.35 10.0 0.3 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein IFT46_B_C PF12317.3 CDI78042.1 - 0.47 9.7 3.2 0.36 10.1 1.1 1.6 1 1 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal GAS PF13851.1 CDI78042.1 - 0.69 9.0 26.9 0.37 9.9 1.7 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding YlqD PF11068.3 CDI78042.1 - 1.3 9.0 21.9 0.06 13.3 1.7 2.3 1 1 1 2 2 2 0 YlqD protein DUF972 PF06156.8 CDI78042.1 - 1.4 9.3 14.2 5.1 7.4 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF2229 PF09989.4 CDI78042.1 - 1.5 8.2 4.7 1.8 7.9 3.3 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Lectin_N PF03954.9 CDI78042.1 - 1.7 8.0 7.4 0.52 9.7 2.1 2.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain FlaC_arch PF05377.6 CDI78042.1 - 3.2 7.7 7.2 7.7 6.4 0.2 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2721 PF11026.3 CDI78042.1 - 4.9 6.8 6.6 9.6 5.8 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Mnd1 PF03962.10 CDI78042.1 - 5.2 6.6 22.9 0.25 10.9 1.1 2.1 1 1 1 2 2 2 0 Mnd1 family DUF4613 PF15390.1 CDI78042.1 - 6.5 4.7 10.2 7.5 4.5 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Fib_alpha PF08702.5 CDI78042.1 - 7.2 6.7 11.4 0.82 9.7 0.5 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 CDI78042.1 - 7.9 6.2 11.4 8.6 6.1 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.10 CDI78042.1 - 9.9 5.2 13.8 13 4.8 9.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit LNS2 PF08235.8 CDI78044.1 - 8.8e-66 220.3 0.0 1.9e-65 219.2 0.0 1.5 2 0 0 2 2 2 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 CDI78044.1 - 0.01 15.4 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 0 lipin, N-terminal conserved region HAD PF12710.2 CDI78044.1 - 0.11 12.5 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.27 CDI78045.1 - 3.9e-15 53.9 0.7 1.7e-07 30.0 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CDI78045.1 - 1.4e-14 52.5 2.4 1.4e-06 27.6 0.1 3.8 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 CDI78045.1 - 1.7e-14 53.7 0.1 7.6e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 CDI78045.1 - 2.2e-11 43.4 0.0 2.2e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 CDI78045.1 - 9.2e-09 34.2 0.3 0.00027 20.1 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 CDI78045.1 - 9.6e-07 28.3 3.0 0.00024 20.6 0.2 3.3 1 1 3 4 4 4 2 EF-hand domain pair PTS_2-RNA PF01885.11 CDI78045.1 - 0.16 11.2 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Spt20 PF12090.3 CDI78047.1 - 0.024 13.9 2.7 3.4 6.9 0.6 2.4 2 0 0 2 2 2 0 Spt20 family Activator_LAG-3 PF11498.3 CDI78047.1 - 1.8 7.2 28.1 0.79 8.3 8.8 2.7 3 0 0 3 3 3 0 Transcriptional activator LAG-3 zf-CCCH PF00642.19 CDI78048.1 - 2.7e-09 36.4 16.4 2.7e-06 26.9 0.2 4.0 3 1 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Robl_LC7 PF03259.12 CDI78048.1 - 0.12 11.9 1.4 0.37 10.3 1.0 1.9 1 0 0 1 1 1 0 Roadblock/LC7 domain IQ PF00612.22 CDI78049.1 - 0.00044 19.6 1.5 0.0011 18.4 0.0 2.5 3 0 0 3 3 3 1 IQ calmodulin-binding motif Med15 PF09606.5 CDI78049.1 - 0.0083 14.3 33.2 0.014 13.6 23.0 1.4 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal BT1 PF03092.11 CDI78051.1 - 6.6e-53 179.9 21.0 6.8e-52 176.6 14.5 2.1 1 1 0 1 1 1 1 BT1 family LRR_8 PF13855.1 CDI78053.1 - 0.00018 21.1 2.1 0.0039 16.8 0.9 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_7 PF13504.1 CDI78053.1 - 0.0048 16.8 0.9 0.87 10.0 0.1 3.8 3 0 0 3 3 3 1 Leucine rich repeat LRR_6 PF13516.1 CDI78053.1 - 0.013 15.5 0.5 0.79 9.9 0.2 3.3 2 1 1 3 3 3 0 Leucine Rich repeat LRR_4 PF12799.2 CDI78053.1 - 0.018 14.6 0.6 0.14 11.8 0.1 2.4 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CDI78053.1 - 0.058 13.4 1.8 0.96 9.7 0.0 3.5 4 0 0 4 4 4 0 Leucine Rich Repeat Acyltransferase PF01553.16 CDI78055.1 - 5.4e-17 61.4 0.0 4.8e-10 38.9 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase PIH1 PF08190.7 CDI78056.1 - 9.6e-05 21.9 0.7 0.0066 15.9 0.0 9.5 6 2 1 8 8 8 2 pre-RNA processing PIH1/Nop17 FimP PF09766.4 CDI78057.1 - 0.43 9.5 5.3 0.43 9.5 3.6 1.1 1 0 0 1 1 1 0 Fms-interacting protein TRAPPC9-Trs120 PF08626.6 CDI78059.1 - 5.9e-16 57.0 5.2 9.5e-08 29.8 0.0 3.9 4 1 0 4 4 4 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit YojJ PF10372.4 CDI78060.1 - 0.1 12.4 3.3 0.16 11.8 0.1 2.6 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Ribosomal_60s PF00428.14 CDI78061.1 - 0.19 12.1 0.1 0.19 12.1 0.1 5.7 5 2 0 5 5 5 0 60s Acidic ribosomal protein Phosphonate-bd PF12974.2 CDI78063.1 - 0.012 14.9 0.2 0.041 13.2 0.1 1.9 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Glyco_transf_41 PF13844.1 CDI78063.1 - 0.2 9.5 0.0 0.31 8.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 Raptor_N PF14538.1 CDI78063.1 - 0.21 11.4 0.0 0.4 10.5 0.0 1.4 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain Herpes_LMP2 PF07415.6 CDI78063.1 - 1.7 7.1 6.6 2.9 6.3 4.5 1.4 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein TMEM247 PF15444.1 CDI78064.1 - 0.013 15.3 1.5 0.02 14.7 1.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 OmpH PF03938.9 CDI78064.1 - 0.043 13.7 7.3 0.071 13.0 5.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Brix PF04427.13 CDI78066.1 - 9.6e-26 90.6 0.0 2e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Brix domain Methyltransf_10 PF05971.7 CDI78070.1 - 1.4e-57 195.1 9.9 7.1e-41 140.2 0.1 4.6 2 1 2 4 4 4 3 Protein of unknown function (DUF890) Methyltransf_18 PF12847.2 CDI78070.1 - 0.04 14.5 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain SPATIAL PF15256.1 CDI78070.1 - 0.86 9.6 11.7 0.28 11.2 2.1 2.6 2 0 0 2 2 2 0 SPATIAL P12 PF12669.2 CDI78070.1 - 7.7 6.8 8.8 12 6.2 4.5 2.5 2 0 0 2 2 2 0 Virus attachment protein p12 family PAT1 PF09770.4 CDI78071.1 - 0.024 12.8 65.8 0.011 14.0 20.2 3.1 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 DUF3661 PF12400.3 CDI78072.1 - 3.6e-31 107.9 1.3 4.4e-31 107.6 0.9 1.1 1 0 0 1 1 1 1 Vaculolar membrane protein DUF3523 PF12037.3 CDI78073.1 - 2.3e-34 118.6 14.1 2.5e-34 118.5 9.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) RolB_RolC PF02027.12 CDI78073.1 - 0.13 11.4 1.3 0.17 11.0 0.9 1.2 1 0 0 1 1 1 0 RolB/RolC glucosidase family Borrelia_P83 PF05262.6 CDI78073.1 - 0.52 8.5 9.2 0.55 8.4 6.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein OmpH PF03938.9 CDI78073.1 - 1.5 8.7 12.8 1.8 8.5 8.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3381 PF11861.3 CDI78073.1 - 3.9 6.9 11.3 5.6 6.4 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) HECT PF00632.20 CDI78075.1 - 6e-34 117.6 0.0 1.1e-32 113.4 0.0 2.4 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) mTERF PF02536.9 CDI78075.1 - 5.5 5.4 0.2 9 4.7 0.1 1.2 1 0 0 1 1 1 0 mTERF HXXEE PF13787.1 CDI78075.1 - 7.9 6.8 0.0 27 5.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function with HXXEE motif AKAP7_NLS PF10469.4 CDI78079.1 - 1.7e-38 132.4 0.2 3.5e-38 131.4 0.2 1.6 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 CDI78079.1 - 0.025 14.2 2.7 0.029 14.0 0.4 2.1 2 1 0 2 2 2 0 2'-5' RNA ligase superfamily ig PF00047.20 CDI78079.1 - 0.14 12.3 0.5 0.31 11.1 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain BRF1 PF07741.8 CDI78079.1 - 0.37 11.0 6.2 0.47 10.6 0.3 2.6 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF4557 PF15101.1 CDI78079.1 - 1.9 8.2 16.1 0.38 10.5 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Med15 PF09606.5 CDI78079.1 - 2 6.5 26.2 0.17 10.0 9.7 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Med3 PF11593.3 CDI78079.1 - 7.4 5.6 16.2 0.69 9.0 4.5 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal OTU PF02338.14 CDI78081.1 - 0.00012 22.6 0.0 0.00028 21.4 0.0 1.7 1 1 1 2 2 2 1 OTU-like cysteine protease LHH PF14411.1 CDI78081.1 - 0.14 12.3 2.2 1.8 8.8 0.0 2.2 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH DUF4106 PF13388.1 CDI78081.1 - 2.1 7.1 7.4 2.9 6.7 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Sec1 PF00995.18 CDI78082.1 - 0.086 11.4 0.0 0.19 10.3 0.0 3.5 4 1 0 4 4 4 0 Sec1 family Het-C PF07217.6 CDI78082.1 - 0.78 7.8 3.5 0.6 8.2 0.6 1.9 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C Mito_carr PF00153.22 CDI78083.1 - 5.2e-12 45.3 0.1 4.1e-06 26.4 0.0 4.6 3 1 1 4 4 4 2 Mitochondrial carrier protein DUF755 PF05501.6 CDI78083.1 - 0.0098 15.9 9.8 0.0098 15.9 6.8 5.3 4 1 1 5 5 5 1 Domain of unknown function (DUF755) DUF3446 PF11928.3 CDI78083.1 - 1.9 8.7 23.5 0.12 12.6 4.2 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF3446) zf-DHHC PF01529.15 CDI78084.1 - 0.18 11.2 4.9 1.4 8.3 1.1 2.9 3 0 0 3 3 3 0 DHHC palmitoyltransferase Peptidase_S49_N PF08496.5 CDI78084.1 - 1.2 8.8 22.4 0.36 10.6 5.1 3.6 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DUF966 PF06136.8 CDI78084.1 - 5.6 6.2 38.3 3.2 7.0 0.6 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF966) Iso_dh PF00180.15 CDI78085.1 - 4.5e-20 71.8 0.0 4.7e-20 71.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-C2HC5 PF06221.8 CDI78086.1 - 0.00047 19.8 4.2 0.0019 17.9 2.9 2.1 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type V-SNARE_C PF12352.3 CDI78087.1 - 0.0008 19.4 0.5 0.0016 18.4 0.4 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.10 CDI78087.1 - 0.0099 16.0 0.2 0.02 15.0 0.2 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus DUF2721 PF11026.3 CDI78087.1 - 0.068 12.8 2.5 0.066 12.8 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF809 PF05663.6 CDI78088.1 - 7 6.5 8.1 14 5.5 5.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF809) CBS PF00571.23 CDI78089.1 - 5.9e-05 22.7 0.5 0.0061 16.3 0.1 3.0 2 1 0 2 2 2 1 CBS domain Spt20 PF12090.3 CDI78089.1 - 0.02 14.2 11.1 1.4 8.2 0.0 2.2 2 0 0 2 2 2 0 Spt20 family IMD PF08397.6 CDI78089.1 - 0.047 13.0 0.6 0.047 13.0 0.4 2.3 2 1 1 3 3 3 0 IRSp53/MIM homology domain zf-DHHC PF01529.15 CDI78089.1 - 0.091 12.1 7.0 0.73 9.2 4.4 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase RR_TM4-6 PF06459.7 CDI78089.1 - 0.11 12.3 12.3 0.17 11.7 8.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.2 CDI78089.1 - 0.8 7.3 5.6 1.1 6.8 3.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TFIIA PF03153.8 CDI78089.1 - 1.2 8.9 25.4 1.6 8.5 17.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAS PF00989.19 CDI78089.1 - 2.1 8.1 6.2 1.1 9.0 0.2 2.3 2 0 0 2 2 2 0 PAS fold SIT PF15330.1 CDI78089.1 - 3.3 7.8 10.8 7.7 6.7 4.4 2.2 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT U1snRNP70_N PF12220.3 CDI78089.1 - 5.4 7.4 14.6 2.2 8.6 3.8 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Pol_alpha_B_N PF08418.5 CDI78089.1 - 7.4 6.0 13.5 14 5.1 9.4 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DS PF01916.12 CDI78091.1 - 7.9e-73 245.1 0.0 1.6e-35 122.6 0.0 3.6 3 1 1 4 4 4 3 Deoxyhypusine synthase PGA2 PF07543.7 CDI78091.1 - 0.0029 17.4 4.8 0.0086 15.8 2.1 2.4 2 0 0 2 2 2 1 Protein trafficking PGA2 CDK2AP PF09806.4 CDI78091.1 - 0.0082 16.3 5.9 0.0082 16.3 4.1 4.8 4 2 0 5 5 5 1 Cyclin-dependent kinase 2-associated protein DUF3537 PF12056.3 CDI78091.1 - 1 8.0 5.3 1.8 7.1 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Suf PF05843.9 CDI78091.1 - 4.5 6.9 11.9 0.4 10.3 4.4 1.9 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) AAA PF00004.24 CDI78092.1 - 4e-73 243.8 0.4 5.2e-45 152.8 0.0 5.0 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI78092.1 - 1.2e-09 38.4 5.1 0.0055 16.8 0.2 5.9 3 2 1 4 4 4 3 AAA domain RuvB_N PF05496.7 CDI78092.1 - 3.8e-08 32.6 0.0 0.0035 16.4 0.0 3.4 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 CDI78092.1 - 3.7e-07 29.9 0.0 0.038 13.7 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CDI78092.1 - 3.4e-06 27.0 4.9 0.22 11.3 0.0 5.6 4 1 1 5 5 5 2 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 CDI78092.1 - 1.1e-05 25.3 0.0 0.28 11.0 0.0 3.5 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.17 CDI78092.1 - 1.2e-05 25.4 0.0 0.077 13.1 0.0 3.0 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.16 CDI78092.1 - 1.7e-05 24.0 0.9 0.16 11.1 0.0 3.4 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 CDI78092.1 - 4.2e-05 23.6 15.2 0.00034 20.6 8.3 7.4 5 3 2 7 7 7 2 AAA ATPase domain TIP49 PF06068.8 CDI78092.1 - 6e-05 21.9 0.0 0.0062 15.2 0.0 2.3 2 0 0 2 2 2 1 TIP49 C-terminus AAA_17 PF13207.1 CDI78092.1 - 0.00013 22.7 0.0 0.16 12.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 CDI78092.1 - 0.00017 21.0 7.9 0.017 14.5 0.0 4.0 4 0 0 4 4 4 2 IstB-like ATP binding protein AAA_3 PF07726.6 CDI78092.1 - 0.00061 19.3 0.0 0.4 10.2 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CDI78092.1 - 0.001 18.5 5.7 1.3 8.4 0.1 4.3 3 1 0 4 4 4 1 AAA domain Arch_ATPase PF01637.13 CDI78092.1 - 0.0027 17.4 0.0 0.87 9.2 0.0 3.5 2 2 1 3 3 3 1 Archaeal ATPase Bac_DnaA PF00308.13 CDI78092.1 - 0.0049 16.5 0.0 0.27 10.8 0.0 3.0 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_33 PF13671.1 CDI78092.1 - 0.026 14.4 30.9 0.13 12.1 0.8 6.4 4 2 0 4 4 4 0 AAA domain KaiC PF06745.8 CDI78092.1 - 0.062 12.4 0.0 27 3.7 0.0 3.3 3 0 0 3 3 3 0 KaiC AAA_24 PF13479.1 CDI78092.1 - 0.78 9.2 0.0 0.78 9.2 0.0 5.5 6 1 1 7 7 7 0 AAA domain SR-25 PF10500.4 CDI78093.1 - 0.16 11.4 9.7 0.26 10.7 6.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PsbQ PF05757.6 CDI78093.1 - 0.52 9.6 3.3 7.9 5.8 0.9 2.2 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) Spore_coat_CotO PF14153.1 CDI78096.1 - 0.0056 16.1 8.7 0.0056 16.1 6.0 3.4 2 1 1 3 3 3 1 Spore coat protein CotO PAT1 PF09770.4 CDI78096.1 - 0.026 12.8 81.2 0.055 11.7 15.2 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 FAM176 PF14851.1 CDI78098.1 - 0.11 12.1 8.2 1.1 8.9 0.0 3.7 3 0 0 3 3 3 0 FAM176 family Myosin_head PF00063.16 CDI78104.1 - 9.7e-30 103.2 0.4 6.3e-19 67.4 0.1 2.3 2 0 0 2 2 2 2 Myosin head (motor domain) Zeta_toxin PF06414.7 CDI78104.1 - 0.0041 16.2 0.1 0.0094 15.0 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 CDI78104.1 - 0.02 15.0 0.1 0.063 13.4 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CDI78104.1 - 0.041 14.6 0.1 0.11 13.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 CDI78104.1 - 0.17 11.5 0.1 0.38 10.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_16 PF13191.1 CDI78104.1 - 0.31 11.0 2.7 0.59 10.0 0.1 2.6 2 1 1 3 3 3 0 AAA ATPase domain Utp14 PF04615.8 CDI78109.1 - 0.33 9.0 41.4 0.38 8.8 28.7 1.0 1 0 0 1 1 1 0 Utp14 protein CDC45 PF02724.9 CDI78109.1 - 0.5 8.3 34.4 0.54 8.2 23.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.1 CDI78109.1 - 4.3 6.5 32.4 4.6 6.4 22.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF572 PF04502.8 CDI78109.1 - 5.7 6.0 34.7 6 5.9 24.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2146 PF10220.4 CDI78109.1 - 6.5 4.5 29.4 7.8 4.3 20.4 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Sec1 PF00995.18 CDI78112.1 - 2.4e-57 194.8 29.9 4.2e-27 95.0 7.3 3.7 1 1 2 3 3 3 3 Sec1 family Oxygenase-NA PF09859.4 CDI78114.1 - 0.091 12.0 0.0 0.47 9.7 0.0 2.0 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA OmpH PF03938.9 CDI78122.1 - 0.00078 19.4 0.0 0.00078 19.4 0.0 5.0 4 2 0 4 4 4 1 Outer membrane protein (OmpH-like) DUF2076 PF09849.4 CDI78123.1 - 0.00046 20.3 9.9 0.00046 20.3 6.9 4.4 5 0 0 5 5 5 1 Uncharacterized protein conserved in bacteria (DUF2076) IncA PF04156.9 CDI78123.1 - 0.0034 17.0 3.5 0.0034 17.0 2.4 3.1 3 0 0 3 3 3 1 IncA protein Neur_chan_memb PF02932.11 CDI78123.1 - 0.017 15.0 1.2 0.82 9.5 0.4 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region AP2 PF00847.15 CDI78123.1 - 0.12 12.5 0.0 0.12 12.5 0.0 6.1 8 0 0 8 8 8 0 AP2 domain Spore_YhcN_YlaJ PF09580.5 CDI78123.1 - 0.24 11.5 4.9 1.7 8.7 1.3 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CDK5_activator PF03261.10 CDI78123.1 - 5 6.3 14.2 5.8 6.1 3.7 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein AIF_C PF14721.1 CDI78123.1 - 8.1 6.6 7.8 1.2 9.3 0.6 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DAGK_acc PF00609.14 CDI78126.1 - 1.1e-14 54.8 0.4 2.7e-12 47.1 0.2 2.3 1 1 1 2 2 2 2 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 CDI78126.1 - 1.7e-13 50.0 1.9 1.2e-12 47.3 0.0 2.6 2 1 0 2 2 2 1 Diacylglycerol kinase catalytic domain Ycf4 PF02392.11 CDI78126.1 - 0.018 14.3 0.1 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Ycf4 SR-25 PF10500.4 CDI78126.1 - 2 7.8 8.2 4.6 6.6 5.7 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DEC-1_N PF04625.8 CDI78126.1 - 2.3 6.8 14.9 3.9 6.0 10.4 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Pkinase_Tyr PF07714.12 CDI78128.1 - 1.7e-50 171.5 0.0 1.2e-48 165.4 0.0 3.1 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 CDI78128.1 - 2.7e-50 170.9 0.4 2.7e-47 161.1 0.0 3.5 4 0 0 4 4 4 2 Protein kinase domain MORN PF02493.15 CDI78128.1 - 3.8e-07 29.4 22.2 0.00074 19.1 1.3 4.7 4 0 0 4 4 4 2 MORN repeat SAM_1 PF00536.25 CDI78128.1 - 0.00069 19.7 0.2 0.0017 18.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1754 PF08555.5 CDI78129.1 - 0.00013 22.5 23.0 12 6.5 15.9 2.6 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Bax1-I PF01027.15 CDI78130.1 - 5.6e-28 97.9 22.0 6.7e-28 97.6 15.2 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CwfJ_C_2 PF04676.9 CDI78131.1 - 4.2e-17 62.4 0.0 4.2e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.10 CDI78131.1 - 0.001 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 BLVR PF06375.6 CDI78131.1 - 0.0051 16.6 8.1 0.0051 16.6 5.6 2.9 2 1 0 2 2 2 1 Bovine leukaemia virus receptor (BLVR) KaiC PF06745.8 CDI78131.1 - 0.053 12.6 0.0 0.088 11.9 0.0 1.2 1 0 0 1 1 1 0 KaiC Neur_chan_memb PF02932.11 CDI78131.1 - 0.88 9.4 13.4 0.52 10.1 3.5 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region APC_15aa PF05972.6 CDI78131.1 - 1.3 9.1 4.5 0.34 11.0 0.8 1.9 2 0 0 2 2 2 0 APC 15 residue motif SOBP PF15279.1 CDI78131.1 - 2.6 8.3 27.5 0.46 10.8 6.5 2.6 2 0 0 2 2 2 0 Sine oculis-binding protein PAT1 PF09770.4 CDI78133.1 - 0.0086 14.3 73.9 0.01 14.0 51.3 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 RabGAP-TBC PF00566.13 CDI78133.1 - 0.0095 15.4 7.1 0.0095 15.4 4.9 2.5 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF4045 PF13254.1 CDI78133.1 - 1.4 8.1 20.8 1.7 7.8 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) PLRV_ORF5 PF01690.12 CDI78133.1 - 2.4 7.1 22.9 3.3 6.7 15.9 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein MFS_1 PF07690.11 CDI78137.1 - 6.6e-17 61.2 21.3 4.7e-16 58.4 14.7 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily UPF0060 PF02694.10 CDI78137.1 - 0.0094 15.9 1.1 0.0094 15.9 0.8 3.5 3 1 1 4 4 4 1 Uncharacterised BCR, YnfA/UPF0060 family EphA2_TM PF14575.1 CDI78137.1 - 0.11 12.9 0.1 1.2 9.5 0.0 2.9 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain PulG PF11773.3 CDI78137.1 - 0.12 12.1 0.0 0.35 10.6 0.0 1.8 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin DUF2215 PF10225.4 CDI78137.1 - 0.31 10.4 7.8 0.27 10.6 3.9 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) Syndecan PF01034.15 CDI78137.1 - 1.5 8.5 4.5 3.8 7.2 0.0 3.1 3 0 0 3 3 3 0 Syndecan domain BAF1_ABF1 PF04684.8 CDI78140.1 - 0.0028 16.5 8.5 0.0028 16.5 5.9 6.0 2 1 3 5 5 5 1 BAF1 / ABF1 chromatin reorganising factor BAF1_ABF1 PF04684.8 CDI78141.1 - 0.0058 15.5 11.9 0.0058 15.5 8.3 4.4 3 2 0 4 4 4 1 BAF1 / ABF1 chromatin reorganising factor ABC2_membrane_3 PF12698.2 CDI78141.1 - 0.018 14.0 0.1 0.033 13.2 0.1 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Zip PF02535.17 CDI78141.1 - 0.059 12.3 0.6 0.11 11.4 0.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CD20 PF04103.10 CDI78141.1 - 0.14 12.0 6.9 0.15 11.9 0.2 2.8 3 0 0 3 3 3 0 CD20-like family TFIIA PF03153.8 CDI78141.1 - 0.6 9.9 47.1 0.061 13.2 7.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Lig_chan PF00060.21 CDI78141.1 - 2 8.1 5.7 2.2 7.9 0.3 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel DUF1644 PF07800.7 CDI78141.1 - 4.6 7.0 11.2 0.56 10.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1644) DUF3357 PF11837.3 CDI78141.1 - 7.3 6.5 15.7 0.053 13.3 0.5 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF3357) FimP PF09766.4 CDI78141.1 - 7.7 5.4 35.9 1.6 7.7 8.3 3.1 3 0 0 3 3 3 0 Fms-interacting protein DUF3449 PF11931.3 CDI78141.1 - 10 5.6 18.2 2.3 7.7 4.9 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3449) Exo_endo_phos PF03372.18 CDI78142.1 - 4.4e-13 49.7 0.0 7.8e-13 48.9 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_60s PF00428.14 CDI78142.1 - 0.36 11.2 18.9 0.21 11.9 0.3 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein DAHP_synth_2 PF01474.11 CDI78146.1 - 8.8e-41 139.6 0.0 1.2e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 Class-II DAHP synthetase family DAHP_synth_2 PF01474.11 CDI78147.1 - 3.4e-37 127.8 0.0 3.6e-37 127.7 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Thioredoxin PF00085.15 CDI78148.1 - 1.1e-06 28.3 0.0 1.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 CDI78148.1 - 0.027 14.6 0.1 0.076 13.2 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain FHA PF00498.21 CDI78149.1 - 0.0011 18.9 0.0 0.0034 17.4 0.0 1.8 1 1 0 1 1 1 1 FHA domain Afi1 PF07792.7 CDI78149.1 - 0.027 14.4 0.7 0.027 14.4 0.5 6.3 6 0 0 6 6 6 0 Docking domain of Afi1 for Arf3 in vesicle trafficking N6_N4_Mtase PF01555.13 CDI78149.1 - 0.11 12.0 0.0 56 3.1 0.0 3.6 4 2 0 4 4 4 0 DNA methylase Inhibitor_I71 PF12628.2 CDI78149.1 - 0.37 10.4 0.0 0.37 10.4 0.0 5.6 6 0 0 6 6 6 0 Falstatin, cysteine peptidase inhibitor ATP-synt PF00231.14 CDI78150.1 - 6.6e-43 147.1 0.0 2.8e-11 43.3 0.0 4.0 1 1 3 4 4 4 4 ATP synthase S19 PF06756.6 CDI78150.1 - 0.00031 20.5 0.3 0.9 9.4 0.0 2.3 2 0 0 2 2 2 2 Chorion protein S19 C-terminal TA0956 PF11513.3 CDI78150.1 - 0.0062 16.5 0.0 2.8 8.0 0.0 2.6 2 0 0 2 2 2 2 Thermoplasma acidophilum protein TA0956 FWWh PF14922.1 CDI78150.1 - 0.28 10.6 1.2 27 4.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function XRN_N PF03159.13 CDI78151.1 - 0.0033 16.8 4.2 0.0033 16.8 2.9 2.6 1 1 2 3 3 3 1 XRN 5'-3' exonuclease N-terminus Neur_chan_memb PF02932.11 CDI78151.1 - 0.87 9.4 16.3 1 9.2 6.2 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ycf1 PF05758.7 CDI78151.1 - 1.6 6.3 29.5 0.54 7.9 4.5 2.1 2 0 0 2 2 2 0 Ycf1 PBP1_TM PF14812.1 CDI78151.1 - 2.7 8.3 15.0 27 5.1 3.2 3.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PPP4R2 PF09184.6 CDI78152.1 - 0.067 12.7 0.1 0.067 12.7 0.0 2.9 3 0 0 3 3 3 0 PPP4R2 DUF1917 PF08939.5 CDI78152.1 - 0.3 10.7 11.9 0.45 10.2 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) Mnd1 PF03962.10 CDI78152.1 - 0.77 9.3 22.2 0.74 9.4 11.4 2.1 2 0 0 2 2 2 0 Mnd1 family DUF1645 PF07816.6 CDI78152.1 - 1 9.8 15.8 2.6 8.4 10.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) RR_TM4-6 PF06459.7 CDI78152.1 - 1.5 8.6 16.9 2.2 8.0 11.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4175 PF13779.1 CDI78152.1 - 2.2 5.8 49.9 2 6.0 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) AAA_23 PF13476.1 CDI78152.1 - 3.9 7.7 19.0 28 4.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 CDI78152.1 - 6.2 6.5 7.8 16 5.2 4.9 1.9 2 0 0 2 2 2 0 Dynamin family Exo_endo_phos PF03372.18 CDI78153.1 - 0.00042 20.3 0.0 0.00097 19.1 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CDP-OH_P_transf PF01066.16 CDI78155.1 - 4.1e-11 43.0 2.6 1.2e-10 41.5 1.8 1.8 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Suf PF05843.9 CDI78155.1 - 0.0018 18.0 5.9 0.0035 17.0 4.1 1.6 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) FimP PF09766.4 CDI78155.1 - 0.39 9.7 10.8 0.68 8.9 7.5 1.3 1 0 0 1 1 1 0 Fms-interacting protein Hid1 PF12722.2 CDI78155.1 - 8.7 3.8 8.0 14 3.2 5.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein KH_1 PF00013.24 CDI78156.1 - 1.4e-29 101.4 3.6 1.3e-14 53.5 0.4 3.2 3 0 0 3 3 3 2 KH domain KH_3 PF13014.1 CDI78156.1 - 5.1e-20 70.6 7.1 4.5e-11 42.1 0.9 3.2 3 0 0 3 3 3 2 KH domain KH_2 PF07650.12 CDI78156.1 - 4.2e-08 32.6 0.6 0.00061 19.2 0.0 2.8 3 0 0 3 3 3 2 KH domain KH_5 PF13184.1 CDI78156.1 - 0.00021 20.9 0.9 0.14 12.0 0.3 2.4 2 0 0 2 2 2 2 NusA-like KH domain KH_4 PF13083.1 CDI78156.1 - 0.00062 19.3 0.9 0.45 10.1 0.1 3.2 3 0 0 3 3 3 1 KH domain WWbp PF10349.4 CDI78156.1 - 0.015 16.1 7.6 0.2 12.5 1.4 2.4 2 0 0 2 2 2 0 WW-domain ligand protein BMC PF00936.14 CDI78156.1 - 0.023 14.3 0.0 0.84 9.3 0.0 2.4 2 0 0 2 2 2 0 BMC domain Mem_trans PF03547.13 CDI78156.1 - 0.12 10.6 1.8 0.14 10.3 1.3 1.3 1 0 0 1 1 1 0 Membrane transport protein Pex14_N PF04695.8 CDI78156.1 - 0.27 11.2 20.4 0.1 12.6 7.7 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-DHHC PF01529.15 CDI78156.1 - 0.36 10.2 2.0 1.1 8.5 0.4 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase Plasmodium_Vir PF05795.6 CDI78156.1 - 0.37 9.9 2.4 0.56 9.3 1.7 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ctr PF04145.10 CDI78156.1 - 1 9.3 8.0 0.76 9.8 3.6 2.0 2 0 0 2 2 2 0 Ctr copper transporter family dUTPase PF00692.14 CDI78156.1 - 1.1 8.7 5.3 5.8 6.3 0.0 3.2 4 0 0 4 4 3 0 dUTPase Vfa1 PF08432.5 CDI78156.1 - 1.1 9.2 13.3 0.051 13.6 4.1 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF1183 PF06682.7 CDI78156.1 - 1.4 8.4 9.0 0.098 12.2 2.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) Mitofilin PF09731.4 CDI78156.1 - 2.2 6.8 24.2 0.0052 15.5 7.2 1.9 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Dicty_REP PF05086.7 CDI78156.1 - 2.7 5.6 6.3 3.7 5.1 4.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hid1 PF12722.2 CDI78156.1 - 2.8 5.5 14.9 0.018 12.7 4.9 1.3 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DUF4199 PF13858.1 CDI78156.1 - 3.1 7.6 9.3 7.8 6.3 3.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DDHD PF02862.12 CDI78156.1 - 3.2 7.4 12.4 2.9 7.6 6.9 1.8 2 0 0 2 2 2 0 DDHD domain Herpes_DNAp_acc PF04929.7 CDI78156.1 - 3.4 6.5 15.8 0.052 12.5 6.1 1.5 2 0 0 2 2 2 0 Herpes DNA replication accessory factor FimP PF09766.4 CDI78156.1 - 4.6 6.1 25.6 0.22 10.5 9.0 2.7 3 0 0 3 3 3 0 Fms-interacting protein Conotoxin PF02950.12 CDI78156.1 - 5.9 7.7 7.6 32 5.4 2.9 2.7 2 0 0 2 2 2 0 Conotoxin FCP1_C PF09309.5 CDI78156.1 - 8.1 5.6 22.1 0.24 10.6 8.5 2.2 2 0 0 2 2 2 0 FCP1, C-terminal CPSF100_C PF13299.1 CDI78156.1 - 8.7 6.5 11.3 19 5.4 6.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Spt20 PF12090.3 CDI78156.1 - 8.9 5.6 26.6 1.5e+03 -1.7 18.4 2.2 1 1 0 1 1 1 0 Spt20 family DNA_pol_viral_N PF00242.12 CDI78156.1 - 10 5.0 14.4 4.8 6.1 4.8 2.1 2 0 0 2 2 2 0 DNA polymerase (viral) N-terminal domain PIP5K PF01504.13 CDI78157.1 - 4.5e-53 179.9 0.0 5.8e-53 179.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DsbC_N PF10411.4 CDI78157.1 - 0.014 14.6 0.0 0.03 13.5 0.0 1.5 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus Mem_trans PF03547.13 CDI78158.1 - 0.08 11.2 2.6 0.11 10.8 0.2 2.1 2 0 0 2 2 2 0 Membrane transport protein Zip PF02535.17 CDI78158.1 - 2.9 6.8 14.1 1.5 7.7 0.0 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter PIG-U PF06728.8 CDI78159.1 - 3.9e-32 111.5 6.3 3.8e-22 78.6 2.4 2.2 1 1 1 2 2 2 2 GPI transamidase subunit PIG-U DUF2803 PF10972.3 CDI78159.1 - 3.7e-05 23.3 1.7 6.8e-05 22.4 1.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2803) DUF2422 PF10337.4 CDI78159.1 - 0.002 17.0 2.1 0.002 17.0 1.5 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF2422) OmpH PF03938.9 CDI78159.1 - 0.042 13.7 42.8 0.11 12.4 16.8 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tetraspannin PF00335.15 CDI78159.1 - 0.065 12.4 0.0 0.065 12.4 0.0 2.6 4 0 0 4 4 4 0 Tetraspanin family Fork_head_N PF08430.7 CDI78159.1 - 0.11 12.8 1.0 0.22 11.8 0.3 1.8 2 0 0 2 2 2 0 Forkhead N-terminal region GOLD_2 PF13897.1 CDI78159.1 - 0.2 11.8 0.3 0.42 10.8 0.2 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF4557 PF15101.1 CDI78159.1 - 0.21 11.4 22.0 0.19 11.5 8.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Multi_Drug_Res PF00893.14 CDI78159.1 - 0.28 11.6 3.4 4.1 7.9 0.5 2.7 2 0 0 2 2 2 0 Small Multidrug Resistance protein HemX PF04375.9 CDI78159.1 - 1.1 7.7 28.7 0.58 8.6 9.8 2.2 2 0 0 2 2 2 0 HemX Pex14_N PF04695.8 CDI78159.1 - 1.1 9.2 21.6 0.026 14.5 5.5 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AIF_C PF14721.1 CDI78159.1 - 1.8 8.8 6.1 0.43 10.8 1.1 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Suf PF05843.9 CDI78159.1 - 1.9 8.1 15.1 0.083 12.6 3.3 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4175 PF13779.1 CDI78159.1 - 4.1 4.9 32.1 0.027 12.1 10.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Gastrin PF00918.12 CDI78159.1 - 5.3 7.8 20.4 5 7.9 0.8 2.6 2 0 0 2 2 2 0 Gastrin/cholecystokinin family RbsD_FucU PF05025.8 CDI78159.1 - 5.3 7.3 9.0 5.9 7.2 1.5 2.2 2 0 0 2 2 2 0 RbsD / FucU transport protein family Spore_YhcN_YlaJ PF09580.5 CDI78159.1 - 7.5 6.6 11.4 0.19 11.8 3.1 1.7 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF4207 PF13904.1 CDI78161.1 - 0.034 13.5 0.1 0.034 13.5 0.1 5.4 3 2 0 3 3 3 0 Domain of unknown function (DUF4207) Conotoxin PF02950.12 CDI78161.1 - 0.034 14.9 2.6 0.034 14.9 1.8 5.1 4 1 1 5 5 5 0 Conotoxin Peptidase_M41 PF01434.13 CDI78162.1 - 2.1e-38 131.9 1.8 2.2e-37 128.5 1.3 2.4 1 1 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 CDI78162.1 - 7.7e-26 90.8 0.0 9.5e-25 87.3 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF4400 PF14348.1 CDI78162.1 - 0.0012 18.2 0.4 0.0012 18.2 0.3 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4400) RuvB_N PF05496.7 CDI78162.1 - 0.014 14.4 0.0 0.03 13.3 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 CDI78162.1 - 0.052 12.2 0.0 0.089 11.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AP2 PF00847.15 CDI78163.1 - 0.0023 18.0 1.6 0.0023 18.0 1.1 2.9 3 0 0 3 3 3 1 AP2 domain zf-CCCH PF00642.19 CDI78164.1 - 2.3e-09 36.7 14.6 1.6e-05 24.4 2.0 3.6 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Dehydrin PF00257.14 CDI78164.1 - 0.9 9.8 0.0 0.9 9.8 0.0 6.1 4 4 0 4 4 4 0 Dehydrin Hist_deacetyl PF00850.14 CDI78165.1 - 8.3e-43 146.8 0.0 8.2e-42 143.5 0.0 2.5 2 1 1 3 3 3 1 Histone deacetylase domain Ank_2 PF12796.2 CDI78165.1 - 2.9e-13 49.9 1.3 4.3e-09 36.5 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI78165.1 - 2.3e-10 40.6 2.9 0.00012 22.4 0.3 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 CDI78165.1 - 5.6e-09 35.3 12.5 2e-06 27.3 0.5 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 CDI78165.1 - 2e-08 34.1 8.0 4.5e-08 33.0 0.7 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI78165.1 - 2.9e-07 30.0 3.2 0.0029 17.6 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat vMSA PF00695.14 CDI78165.1 - 0.17 11.0 3.3 0.34 10.0 2.3 1.4 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus RAP PF08373.5 CDI78166.1 - 0.0029 17.3 0.0 0.0098 15.6 0.0 2.0 1 0 0 1 1 1 1 RAP domain HSP90 PF00183.13 CDI78166.1 - 0.061 11.7 0.2 0.15 10.4 0.1 1.6 1 0 0 1 1 1 0 Hsp90 protein DEAD PF00270.24 CDI78167.1 - 1.2e-19 70.4 5.5 1e-18 67.3 0.7 3.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI78167.1 - 3.8e-13 49.0 0.1 6.4e-12 45.1 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDI78167.1 - 0.021 14.9 1.1 13 5.9 0.0 3.9 3 1 1 4 4 4 0 AAA domain RAP1 PF07218.6 CDI78169.1 - 1.7 6.6 8.3 2.3 6.1 5.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.4 CDI78169.1 - 6.6 4.8 5.4 10 4.2 3.8 1.2 1 0 0 1 1 1 0 Transmembrane protein APC_CDC26 PF10471.4 CDI78170.1 - 0.00052 20.6 3.2 0.00052 20.6 2.2 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex APC subunit 1 SGT1 PF07093.6 CDI78170.1 - 0.01 14.2 3.8 0.012 14.0 2.6 1.1 1 0 0 1 1 1 0 SGT1 protein PAT1 PF09770.4 CDI78170.1 - 0.14 10.3 23.1 0.14 10.4 16.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FHIPEP PF00771.15 CDI78170.1 - 0.31 9.3 2.3 0.39 8.9 1.6 1.1 1 0 0 1 1 1 0 FHIPEP family RAP1 PF07218.6 CDI78170.1 - 3.7 5.5 6.2 4 5.4 4.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Cwf_Cwc_15 PF04889.7 CDI78170.1 - 6 6.4 11.4 13 5.3 7.9 1.6 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein EI24 PF07264.6 CDI78171.1 - 4.1e-08 32.9 7.6 0.0062 15.9 0.1 3.4 3 0 0 3 3 3 3 Etoposide-induced protein 2.4 (EI24) SR-25 PF10500.4 CDI78171.1 - 0.0026 17.2 9.9 0.0026 17.2 6.9 4.7 4 2 1 5 5 5 1 Nuclear RNA-splicing-associated protein Spore_coat_CotO PF14153.1 CDI78171.1 - 0.0071 15.8 0.7 0.0071 15.8 0.5 5.6 5 1 0 5 5 5 1 Spore coat protein CotO Plasmodium_Vir PF05795.6 CDI78171.1 - 1.7 7.8 0.0 1.7 7.8 0.0 3.3 2 2 0 2 2 2 0 Plasmodium vivax Vir protein Slu7 PF11708.3 CDI78173.1 - 5e-61 206.4 45.5 6.2e-57 193.0 8.5 3.5 2 1 2 4 4 4 2 Pre-mRNA splicing Prp18-interacting factor Dicty_REP PF05086.7 CDI78173.1 - 5.1 4.7 8.3 8.3 4.0 5.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SIR2 PF02146.12 CDI78174.1 - 1.2e-28 100.0 0.0 1.6e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.17 CDI78174.1 - 9e-06 25.4 0.0 1.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain GMC_oxred_N PF00732.14 CDI78176.1 - 4.3e-18 65.4 0.1 1.5e-08 34.1 0.0 2.6 3 0 0 3 3 3 2 GMC oxidoreductase GMC_oxred_C PF05199.8 CDI78176.1 - 4.2e-09 36.8 0.0 0.00026 21.2 0.0 2.7 2 0 0 2 2 2 2 GMC oxidoreductase GIDA PF01134.17 CDI78176.1 - 0.00011 21.1 1.5 0.00019 20.3 1.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 CDI78176.1 - 0.00016 20.6 2.1 0.00029 19.8 1.4 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 CDI78176.1 - 0.00022 21.1 1.1 0.00056 19.8 0.8 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CDI78176.1 - 0.00027 19.5 0.3 0.00042 18.9 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.19 CDI78176.1 - 0.00044 19.2 3.2 0.00089 18.2 2.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CDI78176.1 - 0.0019 17.3 0.1 0.0034 16.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CDI78176.1 - 0.0025 16.9 1.0 0.0049 15.9 0.7 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CDI78176.1 - 0.0032 17.8 0.2 0.016 15.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI78176.1 - 0.0051 15.9 0.2 0.013 14.5 0.0 1.7 2 0 0 2 2 2 1 Thi4 family GDI PF00996.13 CDI78176.1 - 0.0068 14.7 0.0 0.012 14.0 0.0 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor Pyr_redox_2 PF07992.9 CDI78176.1 - 0.01 15.7 1.5 0.01 15.7 1.0 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDI78176.1 - 0.065 13.2 0.2 0.16 12.0 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 CDI78176.1 - 0.16 10.8 0.1 0.28 10.0 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Ribosomal_L22 PF00237.14 CDI78178.1 - 3e-22 78.5 0.2 4.1e-22 78.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Attacin_C PF03769.10 CDI78178.1 - 0.094 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Attacin, C-terminal region ELFV_dehydrog_N PF02812.13 CDI78179.1 - 3.5e-38 130.1 0.0 1.8e-37 127.8 0.0 2.2 2 1 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.16 CDI78179.1 - 2.7e-26 92.6 0.2 3.8e-26 92.1 0.1 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.1 CDI78179.1 - 0.0017 18.6 0.1 0.0027 17.9 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding AdoHcyase_NAD PF00670.16 CDI78179.1 - 0.081 12.7 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 CDI78179.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 CDI78179.1 - 0.14 11.9 0.1 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 ThiF family PGK PF00162.14 CDI78180.1 - 2.6e-114 381.7 0.0 6.3e-114 380.5 0.0 1.6 1 1 0 1 1 1 1 Phosphoglycerate kinase zf-CCHC_3 PF13917.1 CDI78181.1 - 6.3e-17 61.0 3.7 6.3e-17 61.0 2.6 2.1 2 0 0 2 2 2 1 Zinc knuckle PAT1 PF09770.4 CDI78181.1 - 0.11 10.7 74.9 0.037 12.2 3.2 3.2 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 Tuberin PF03542.11 CDI78181.1 - 0.4 9.7 0.0 0.4 9.7 0.0 2.2 3 0 0 3 3 3 0 Tuberin Bestrophin PF01062.16 CDI78181.1 - 1.4 7.8 5.5 2.3 7.1 0.1 3.0 3 0 0 3 3 3 0 Bestrophin, RFP-TM, chloride channel Chorein_N PF12624.2 CDI78182.1 - 0.00017 21.1 0.1 0.00017 21.1 0.0 5.6 5 0 0 5 5 5 1 N-terminal region of Chorein, a TM vesicle-mediated sorter OmpH PF03938.9 CDI78182.1 - 0.37 10.7 0.0 0.37 10.7 0.0 29.8 15 6 2 19 19 19 0 Outer membrane protein (OmpH-like) WD40 PF00400.27 CDI78183.1 - 7.1e-34 114.4 35.6 3e-07 30.0 0.1 11.4 11 0 0 11 11 11 8 WD domain, G-beta repeat IncA PF04156.9 CDI78183.1 - 9.5e-05 22.0 8.2 9.5e-05 22.0 5.7 4.7 4 0 0 4 4 4 2 IncA protein zf-DHHC PF01529.15 CDI78183.1 - 0.049 13.0 1.0 2.7 7.3 0.1 2.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase Med3 PF11593.3 CDI78184.1 - 0.0036 16.5 1.7 0.0036 16.5 1.2 2.5 2 1 0 2 2 2 1 Mediator complex subunit 3 fungal RTC PF01137.16 CDI78184.1 - 0.007 15.1 0.0 0.0077 15.0 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase COX16 PF14138.1 CDI78184.1 - 0.08 13.1 0.3 0.23 11.6 0.2 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Thioredoxin_8 PF13905.1 CDI78185.1 - 6.6e-14 51.8 0.0 1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like PI3_PI4_kinase PF00454.22 CDI78186.1 - 4.5e-34 117.9 0.1 9.5e-34 116.8 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 CDI78186.1 - 3.2e-09 36.2 0.2 3.9e-07 29.4 0.0 2.9 3 0 0 3 3 3 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.19 CDI78186.1 - 0.00022 21.0 1.2 0.0012 18.6 0.0 2.9 3 0 0 3 3 3 1 Phosphoinositide 3-kinase C2 Lactamase_B_2 PF12706.2 CDI78187.1 - 1.3e-26 93.3 0.2 2.9e-19 69.3 0.0 3.1 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CDI78187.1 - 3.3e-09 36.6 3.9 5.6e-07 29.4 0.0 2.9 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.22 CDI78187.1 - 0.0025 17.5 0.5 0.009 15.6 0.1 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Sec10 PF07393.6 CDI78188.1 - 0.22 9.6 15.6 0.26 9.4 10.8 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec10 DUF1777 PF08648.7 CDI78188.1 - 0.31 10.7 19.8 0.35 10.5 13.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF913 PF06025.7 CDI78188.1 - 0.97 8.1 12.6 1.4 7.5 8.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Endostatin PF06482.6 CDI78188.1 - 1.8 7.8 14.9 2.4 7.4 10.3 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Suf PF05843.9 CDI78188.1 - 6.8 6.3 31.0 9.6 5.8 21.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4045 PF13254.1 CDI78188.1 - 7 5.8 21.2 7.3 5.7 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF605 PF04652.11 CDI78190.1 - 0.0051 16.2 3.7 0.0053 16.2 2.6 1.1 1 0 0 1 1 1 1 Vta1 like EFG_IV PF03764.13 CDI78190.1 - 0.03 13.8 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor G, domain IV PIH1 PF08190.7 CDI78190.1 - 0.12 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 Sec3_C PF09763.4 CDI78190.1 - 0.27 9.3 9.2 0.32 9.0 6.4 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF572 PF04502.8 CDI78190.1 - 3.4 6.7 9.0 4.9 6.2 6.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) NPR3 PF03666.8 CDI78190.1 - 4.8 5.6 10.6 7.3 4.9 7.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SSP160 PF06933.6 CDI78190.1 - 7.2 4.4 40.7 8.8 4.1 28.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DNA_pol_viral_N PF00242.12 CDI78190.1 - 8 5.3 23.4 20 4.0 16.2 1.7 2 0 0 2 2 2 0 DNA polymerase (viral) N-terminal domain Shadoo PF14999.1 CDI78191.1 - 4.5 7.1 9.5 1.1 9.1 4.1 1.7 1 1 0 1 1 1 0 Shadow of prion protein, neuroprotective PAT1 PF09770.4 CDI78193.1 - 0.98 7.5 39.9 1.1 7.3 27.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med3 PF11593.3 CDI78194.1 - 0.00078 18.7 1.1 0.00078 18.7 0.8 6.3 3 3 2 6 6 6 1 Mediator complex subunit 3 fungal Pox_Ag35 PF03286.9 CDI78195.1 - 0.69 9.3 25.2 0.78 9.2 17.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Paf1 PF03985.8 CDI78195.1 - 1.3 7.6 35.5 1.6 7.4 24.6 1.0 1 0 0 1 1 1 0 Paf1 CAF-1_p150 PF11600.3 CDI78195.1 - 1.4 8.2 37.2 1.6 8.0 25.8 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Vfa1 PF08432.5 CDI78195.1 - 3.1 7.7 29.8 3.5 7.5 20.7 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CobT PF06213.7 CDI78195.1 - 3.2 6.8 29.5 3.8 6.5 20.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Trypan_PARP PF05887.6 CDI78195.1 - 4.8 7.0 12.7 6.6 6.5 8.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nha1_C PF08619.5 CDI78195.1 - 5.6 6.1 31.3 6.2 5.9 21.7 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus RNA_pol_3_Rpc31 PF11705.3 CDI78195.1 - 6.1 6.7 22.8 8 6.3 15.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF1510 PF07423.6 CDI78195.1 - 6.4 6.0 33.5 7.1 5.9 23.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Spc7_N PF15402.1 CDI78195.1 - 6.9 4.5 25.6 8.2 4.2 17.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF2072 PF09845.4 CDI78195.1 - 8.3 6.3 17.6 11 6.0 12.2 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) DUF2052 PF09747.4 CDI78195.1 - 8.4 6.2 36.1 10 5.9 25.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Caldesmon PF02029.10 CDI78195.1 - 8.5 4.6 36.1 9.4 4.5 25.0 1.0 1 0 0 1 1 1 0 Caldesmon DUF2215 PF10225.4 CDI78195.1 - 9 5.6 16.7 12 5.1 11.6 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Pal1 PF08316.6 CDI78195.1 - 9.5 6.6 11.9 13 6.1 8.3 1.4 1 0 0 1 1 1 0 Pal1 cell morphology protein DDRGK PF09756.4 CDI78195.1 - 9.6 5.5 42.7 12 5.2 29.6 1.1 1 0 0 1 1 1 0 DDRGK domain Pkinase PF00069.20 CDI78198.1 - 1.8e-08 33.9 0.1 2e-08 33.6 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 CDI78198.1 - 4.5e-05 22.6 0.3 7e-05 21.9 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 CDI78198.1 - 0.0068 15.4 0.0 0.0082 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-bind_6 PF13921.1 CDI78199.1 - 8.7e-06 25.7 1.1 1.5e-05 24.9 0.7 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CDI78199.1 - 0.0035 17.3 0.2 0.0065 16.4 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_L22 PF00237.14 CDI78201.1 - 8.1e-05 22.5 0.0 0.00034 20.5 0.0 2.1 2 1 0 2 2 2 1 Ribosomal protein L22p/L17e DUF1764 PF08576.5 CDI78201.1 - 0.062 14.0 0.7 0.11 13.2 0.5 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TFIIF_beta PF02270.10 CDI78202.1 - 1.1e-06 28.6 0.1 1.3e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit THOC7 PF05615.8 CDI78202.1 - 0.0015 18.7 0.3 0.0018 18.5 0.2 1.1 1 0 0 1 1 1 1 Tho complex subunit 7 RPA_C PF08784.6 CDI78202.1 - 0.086 13.2 0.3 0.19 12.1 0.1 1.7 1 1 1 2 2 2 0 Replication protein A C terminal DUF1888 PF08985.6 CDI78204.1 - 0.0061 16.2 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1888) AAA_16 PF13191.1 CDI78205.1 - 1.2e-06 28.6 0.6 4.4e-05 23.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Arch_ATPase PF01637.13 CDI78205.1 - 0.0016 18.2 0.1 0.004 16.8 0.0 1.7 2 0 0 2 2 2 1 Archaeal ATPase AAA PF00004.24 CDI78205.1 - 0.012 15.7 0.0 0.051 13.7 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI78205.1 - 0.039 13.6 0.0 0.093 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 CDI78205.1 - 0.081 12.5 0.0 0.44 10.1 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 CDI78205.1 - 0.11 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDI78205.1 - 0.14 11.3 0.0 0.36 10.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DEAD PF00270.24 CDI78206.1 - 3.6e-24 85.1 0.0 1.2e-22 80.1 0.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CDI78206.1 - 3.2e-05 23.8 0.0 3.2e-05 23.8 0.0 2.3 1 1 0 2 2 1 1 Type III restriction enzyme, res subunit SAGA-Tad1 PF12767.2 CDI78206.1 - 0.0019 17.9 10.3 0.0028 17.3 7.2 1.3 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit SecA_DEAD PF07517.9 CDI78206.1 - 0.0044 16.3 0.2 0.0086 15.3 0.2 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain Med15 PF09606.5 CDI78206.1 - 0.023 12.9 38.0 0.038 12.2 26.3 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI78206.1 - 0.036 11.8 11.3 0.047 11.4 7.8 1.1 1 0 0 1 1 1 0 Ycf1 LMBR1 PF04791.11 CDI78206.1 - 0.072 11.6 0.7 0.093 11.2 0.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SAPS PF04499.10 CDI78206.1 - 0.1 11.2 6.7 0.13 10.8 4.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Mem_trans PF03547.13 CDI78206.1 - 0.21 9.8 0.0 0.19 9.9 0.0 1.1 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.12 CDI78206.1 - 0.21 10.3 11.0 0.39 9.4 7.6 1.4 1 0 0 1 1 1 0 Presenilin SOBP PF15279.1 CDI78206.1 - 0.38 11.0 12.2 0.61 10.4 8.5 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CDC27 PF09507.5 CDI78206.1 - 1 8.5 29.9 1.7 7.7 20.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Daxx PF03344.10 CDI78206.1 - 1 7.7 22.5 1.4 7.2 15.6 1.1 1 0 0 1 1 1 0 Daxx Family UPF0564 PF10595.4 CDI78206.1 - 1.2 7.9 30.7 1.7 7.5 21.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 Hid1 PF12722.2 CDI78206.1 - 2.3 5.7 18.4 3.1 5.3 12.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.9 CDI78206.1 - 2.4 6.0 18.5 3.3 5.6 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.1 CDI78206.1 - 5 6.8 14.6 8 6.1 10.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF1510 PF07423.6 CDI78206.1 - 5.7 6.2 23.9 9.8 5.4 16.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PAT1 PF09770.4 CDI78206.1 - 5.8 5.0 32.3 7.9 4.5 22.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 XAP5 PF04921.9 CDI78206.1 - 5.9 6.3 13.3 9.9 5.6 9.2 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator Neur_chan_memb PF02932.11 CDI78206.1 - 7.5 6.3 13.1 11 5.8 9.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S15 PF02129.13 CDI78206.1 - 8.1 5.7 10.5 17 4.7 7.3 1.5 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) IncA PF04156.9 CDI78207.1 - 0.00064 19.3 6.1 0.00064 19.3 4.2 6.2 4 2 0 4 4 4 2 IncA protein TrkH PF02386.11 CDI78207.1 - 0.084 11.4 0.0 0.17 10.3 0.0 1.4 1 0 0 1 1 1 0 Cation transport protein B12D PF06522.6 CDI78207.1 - 2.1 8.1 0.0 2.1 8.1 0.0 4.1 5 0 0 5 5 5 0 NADH-ubiquinone reductase complex 1 MLRQ subunit WD40 PF00400.27 CDI78208.1 - 6.1e-78 254.1 12.9 5e-14 51.5 0.1 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat eIF2A PF08662.6 CDI78208.1 - 1e-05 25.3 0.0 0.1 12.2 0.0 2.6 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A NLE PF08154.7 CDI78208.1 - 2.1e-05 24.4 0.0 3.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 CDI78208.1 - 0.009 14.2 0.0 0.009 14.2 0.0 4.2 4 1 1 5 5 5 1 Nucleoporin Nup120/160 Dehydrin PF00257.14 CDI78208.1 - 0.052 13.8 3.5 0.23 11.7 0.1 2.3 2 0 0 2 2 2 0 Dehydrin SR-25 PF10500.4 CDI78208.1 - 0.26 10.7 31.0 0.2 11.0 4.9 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein EF-hand_4 PF12763.2 CDI78209.1 - 9.9e-12 44.5 0.0 7.8e-06 25.5 0.0 2.9 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 CDI78209.1 - 0.00057 18.9 0.0 0.0028 16.8 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 CDI78209.1 - 0.00077 19.5 0.0 0.0095 16.0 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 CDI78209.1 - 0.02 14.7 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain CLAMP PF14769.1 CDI78210.1 - 1.4e-14 54.0 0.2 2.4e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 Pro_isomerase PF00160.16 CDI78211.1 - 4.7e-28 98.3 0.0 6.7e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BRO1 PF03097.13 CDI78213.1 - 3.1e-15 55.8 0.2 3.2e-14 52.4 1.1 4.1 3 2 1 4 4 4 2 BRO1-like domain PAT1 PF09770.4 CDI78213.1 - 4.8 5.2 97.0 0.16 10.1 31.6 2.4 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Prenyltrans_1 PF13243.1 CDI78214.1 - 0.085 12.8 1.2 0.44 10.5 0.3 2.3 1 1 1 2 2 2 0 Prenyltransferase-like Prenyltrans_2 PF13249.1 CDI78214.1 - 0.6 10.5 3.7 5.5 7.4 0.8 2.6 2 1 0 2 2 2 0 Prenyltransferase-like DUF572 PF04502.8 CDI78214.1 - 2.7 7.1 17.0 5.1 6.2 11.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S64 PF08192.6 CDI78214.1 - 4.7 5.4 6.3 6.2 5.0 4.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Cwf_Cwc_15 PF04889.7 CDI78218.1 - 0.12 12.0 31.8 0.14 11.8 22.1 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Trypan_PARP PF05887.6 CDI78218.1 - 0.9 9.3 5.0 1 9.1 3.5 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) POX PF07526.6 CDI78218.1 - 6.4 6.9 28.4 7.5 6.7 19.7 1.0 1 0 0 1 1 1 0 Associated with HOX BTV_NS2 PF04514.7 CDI78218.1 - 7.6 5.3 21.8 9.4 5.0 15.1 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Raftlin PF15250.1 CDI78218.1 - 8.3 4.8 25.3 8.9 4.7 17.5 1.0 1 0 0 1 1 1 0 Raftlin SR-25 PF10500.4 CDI78219.1 - 0.00038 19.9 14.7 0.00038 19.9 10.2 4.3 5 0 0 5 5 5 1 Nuclear RNA-splicing-associated protein RAB3GAP2_N PF14655.1 CDI78219.1 - 0.01 14.8 1.0 0.01 14.8 0.7 2.8 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus ORC3_N PF07034.6 CDI78219.1 - 0.71 8.7 6.5 0.71 8.7 0.1 2.5 3 0 0 3 3 3 0 Origin recognition complex (ORC) subunit 3 N-terminus Ank_5 PF13857.1 CDI78220.1 - 5.1e-06 26.5 14.9 0.00014 21.9 0.9 6.3 6 0 0 6 6 6 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI78220.1 - 7e-06 26.2 0.1 7e-06 26.2 0.1 6.2 7 0 0 7 7 7 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI78220.1 - 2.8e-05 24.4 14.6 0.0031 18.0 0.1 6.7 7 0 0 7 7 7 1 Ankyrin repeats (many copies) LRR_4 PF12799.2 CDI78220.1 - 0.00042 19.8 12.9 0.0085 15.6 5.3 3.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) OmpH PF03938.9 CDI78220.1 - 0.0041 17.0 0.0 0.0041 17.0 0.0 14.1 9 5 1 10 10 10 1 Outer membrane protein (OmpH-like) Ank PF00023.25 CDI78220.1 - 0.0055 16.4 0.8 0.0055 16.4 0.5 6.4 6 0 0 6 6 6 1 Ankyrin repeat Reticulon PF02453.12 CDI78224.1 - 0.00033 20.2 1.5 0.025 14.1 0.0 2.8 1 1 1 2 2 2 1 Reticulon FimP PF09766.4 CDI78224.1 - 0.0038 16.3 3.4 0.0038 16.3 2.3 4.2 3 1 1 4 4 4 1 Fms-interacting protein FAM176 PF14851.1 CDI78224.1 - 0.0072 16.0 4.5 0.0072 16.0 3.2 4.1 2 2 1 3 3 3 1 FAM176 family Ni_hydr_CYTB PF01292.15 CDI78224.1 - 0.15 11.4 0.5 6.8 6.0 0.1 2.5 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 Cytochrom_B_N PF00033.14 CDI78224.1 - 0.75 9.1 4.7 17 4.6 0.0 2.8 2 1 0 2 2 2 0 Cytochrome b(N-terminal)/b6/petB Zip PF02535.17 CDI78224.1 - 1.4 7.8 20.7 0.17 10.8 0.7 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter Thioredoxin_2 PF13098.1 CDI78227.1 - 0.0099 16.0 0.7 0.022 14.9 0.1 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain AAA_23 PF13476.1 CDI78227.1 - 0.041 14.2 15.2 0.15 12.3 3.3 2.1 2 0 0 2 2 2 0 AAA domain zf-DHHC PF01529.15 CDI78227.1 - 0.14 11.5 3.0 0.056 12.8 0.3 1.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF3450 PF11932.3 CDI78227.1 - 0.71 9.0 24.3 0.12 11.6 6.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Plasmodium_Vir PF05795.6 CDI78227.1 - 1.2 8.3 4.1 1.5 7.9 2.8 1.3 1 1 0 1 1 1 0 Plasmodium vivax Vir protein DUF912 PF06024.7 CDI78227.1 - 1.2 9.2 4.0 0.48 10.4 0.3 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Neur_chan_memb PF02932.11 CDI78227.1 - 1.5 8.6 4.1 2.5 7.9 2.8 1.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.10 CDI78227.1 - 1.6 7.3 7.8 0.11 11.1 1.6 1.7 2 0 0 2 2 2 0 Serine incorporator (Serinc) GBP_C PF02841.9 CDI78227.1 - 1.8 7.6 22.1 0.11 11.6 5.2 2.2 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain FAR1 PF03101.10 CDI78227.1 - 1.9 9.0 7.2 0.57 10.7 2.3 2.0 2 0 0 2 2 2 0 FAR1 DNA-binding domain SPT16 PF08644.6 CDI78227.1 - 3.1 7.6 10.0 1.6 8.5 1.3 2.2 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) DUF1525 PF07511.6 CDI78227.1 - 3.1 7.8 16.3 0.077 12.9 4.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) OATP PF03137.15 CDI78227.1 - 3.6 5.5 5.5 1.4 6.8 0.8 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family LMBR1 PF04791.11 CDI78227.1 - 4.4 5.7 7.0 3.4 6.1 1.2 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4557 PF15101.1 CDI78227.1 - 4.7 6.9 17.8 0.95 9.2 7.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Band_3_cyto PF07565.8 CDI78227.1 - 6.2 6.2 14.5 0.15 11.5 3.0 2.4 3 0 0 3 3 3 0 Band 3 cytoplasmic domain Peptidase_S49_N PF08496.5 CDI78227.1 - 9.4 6.0 12.6 0.8 9.4 4.4 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SRP14 PF02290.10 CDI78228.1 - 2.1e-15 56.3 0.0 2.1e-15 56.3 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle 14kD protein SeqA PF03925.8 CDI78228.1 - 0.23 11.1 6.2 0.33 10.6 4.3 1.3 1 0 0 1 1 1 0 SeqA protein DDHD PF02862.12 CDI78228.1 - 0.39 10.4 7.3 0.4 10.4 5.0 1.2 1 0 0 1 1 1 0 DDHD domain DUF1675 PF07897.6 CDI78228.1 - 0.53 10.1 9.1 0.61 9.9 6.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) RR_TM4-6 PF06459.7 CDI78228.1 - 0.91 9.3 9.1 0.95 9.2 6.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EIIBC-GUT_N PF03612.9 CDI78228.1 - 1.2 8.7 5.8 1.4 8.5 4.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2735 PF10931.3 CDI78228.1 - 1.2 9.4 0.0 1.2 9.4 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2735) Peptidase_S49_N PF08496.5 CDI78228.1 - 2.4 7.9 11.4 3.3 7.4 7.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal G0-G1_switch_2 PF15103.1 CDI78228.1 - 3.2 8.0 5.7 5.9 7.1 3.9 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF4106 PF13388.1 CDI78228.1 - 4.1 6.2 14.8 4.6 6.0 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) MDFI PF15316.1 CDI78228.1 - 7.5 6.5 6.5 9.9 6.1 4.5 1.2 1 0 0 1 1 1 0 MyoD family inhibitor Herpes_DNAp_acc PF04929.7 CDI78228.1 - 9.6 5.0 14.0 13 4.6 9.7 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor UCH PF00443.24 CDI78229.1 - 2.7e-42 144.7 0.0 5.8e-42 143.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 CDI78229.1 - 5e-12 45.7 0.0 5.9e-11 42.3 0.0 2.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 CDI78229.1 - 5.6e-10 38.7 5.6 0.00014 21.5 0.0 4.2 4 0 0 4 4 4 2 UBA/TS-N domain UCH_1 PF13423.1 CDI78229.1 - 1.7e-09 37.5 0.1 0.00014 21.3 0.0 3.3 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase ArfGap PF01412.13 CDI78229.1 - 0.079 12.7 0.3 0.3 10.8 0.2 2.0 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf OmpH PF03938.9 CDI78230.1 - 0.31 10.9 18.3 0.52 10.2 12.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TcdA_TcdB PF12919.2 CDI78230.1 - 0.34 9.3 7.0 0.52 8.7 4.8 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain ArgK PF03308.11 CDI78230.1 - 0.6 8.8 4.5 0.84 8.3 3.1 1.2 1 0 0 1 1 1 0 ArgK protein Transposase_22 PF02994.9 CDI78230.1 - 0.79 8.1 10.9 1.2 7.5 7.6 1.3 1 0 0 1 1 1 0 L1 transposable element Retrotrans_gag PF03732.12 CDI78230.1 - 2.2 8.4 12.1 9.7 6.3 8.2 2.3 2 1 0 2 2 2 0 Retrotransposon gag protein DHC_N2 PF08393.8 CDI78231.1 - 6.3e-78 262.0 5.7 4.2e-53 180.3 0.0 3.3 3 0 0 3 3 3 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 CDI78231.1 - 1.1e-59 201.7 0.2 7.5e-35 120.5 0.0 3.5 2 1 1 3 3 3 3 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 CDI78231.1 - 3.3e-30 105.1 0.0 1.2e-29 103.2 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 CDI78231.1 - 7e-12 45.2 0.1 4.6e-05 23.1 0.0 4.7 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.24 CDI78231.1 - 1.8e-05 24.9 0.3 1 9.5 0.0 4.5 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI78231.1 - 3.2e-05 24.0 0.1 0.18 11.7 0.0 4.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.1 CDI78231.1 - 7.2e-05 22.6 0.1 0.039 13.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 CDI78231.1 - 0.00016 21.3 1.6 0.16 11.7 0.0 3.7 3 0 0 3 3 3 1 Part of AAA domain Viral_helicase1 PF01443.13 CDI78231.1 - 0.00019 21.0 0.1 0.29 10.5 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.1 CDI78231.1 - 0.00039 21.2 0.0 0.6 10.9 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 CDI78231.1 - 0.00076 19.7 2.2 0.11 12.7 0.0 3.8 4 0 0 4 4 3 1 AAA domain AAA_25 PF13481.1 CDI78231.1 - 0.001 18.4 1.2 0.11 11.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CDI78231.1 - 0.0011 19.1 0.0 1.1 9.3 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.1 CDI78231.1 - 0.0011 18.9 0.5 0.46 10.4 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.1 CDI78231.1 - 0.0012 18.3 0.7 0.037 13.5 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 CDI78231.1 - 0.007 16.3 0.0 0.057 13.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.7 CDI78231.1 - 0.011 14.8 0.4 0.089 11.8 0.1 2.7 3 0 0 3 3 2 0 Zeta toxin Mg_chelatase PF01078.16 CDI78231.1 - 0.013 14.6 1.9 0.12 11.5 0.1 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 CDI78231.1 - 0.018 14.7 2.0 2.3 7.8 0.0 3.7 3 1 0 3 3 2 0 NACHT domain Miro PF08477.8 CDI78231.1 - 0.021 15.2 0.0 2.7 8.5 0.0 3.7 4 0 0 4 4 3 0 Miro-like protein FtsK_SpoIIIE PF01580.13 CDI78231.1 - 0.025 14.0 0.6 0.52 9.7 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family ABC_tran PF00005.22 CDI78231.1 - 0.029 14.6 0.2 0.21 11.8 0.0 2.6 3 0 0 3 3 1 0 ABC transporter RNA_helicase PF00910.17 CDI78231.1 - 0.096 12.8 0.1 3.5 7.8 0.0 3.1 3 0 0 3 3 2 0 RNA helicase AAA_11 PF13086.1 CDI78231.1 - 0.15 11.6 2.7 4.7 6.7 0.0 3.7 3 0 0 3 3 3 0 AAA domain Dynein_heavy PF03028.10 CDI78232.1 - 5.8e-139 464.2 0.0 1.5e-137 459.5 0.0 2.2 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor MT PF12777.2 CDI78232.1 - 1.6e-39 135.6 5.1 1.6e-39 135.6 3.5 1.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 CDI78232.1 - 1.4e-33 115.6 0.0 3e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 IncA PF04156.9 CDI78232.1 - 0.0088 15.6 1.6 0.0088 15.6 1.1 2.0 2 0 0 2 2 2 1 IncA protein Spc7 PF08317.6 CDI78232.1 - 0.021 13.5 2.5 0.056 12.0 1.7 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein CorA PF01544.13 CDI78232.1 - 0.25 10.3 6.5 0.068 12.2 0.3 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein V_ATPase_I PF01496.14 CDI78232.1 - 0.67 7.7 1.7 0.64 7.8 0.1 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DegT_DnrJ_EryC1 PF01041.12 CDI78233.1 - 6.9e-17 61.5 0.0 4.1e-16 58.9 0.0 1.9 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family WW PF00397.21 CDI78234.1 - 9e-08 31.8 1.3 1.8e-07 30.8 0.9 1.5 1 0 0 1 1 1 1 WW domain ABC_tran PF00005.22 CDI78235.1 - 5.1e-22 78.6 0.0 8.5e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 CDI78235.1 - 1.6e-10 40.4 3.1 2.7e-05 23.4 0.5 2.5 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.1 CDI78235.1 - 2.9e-05 24.1 0.3 0.031 14.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CDI78235.1 - 0.00031 19.9 0.1 0.00056 19.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CDI78235.1 - 0.0034 16.8 0.1 0.0084 15.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 CDI78235.1 - 0.021 14.2 0.0 0.059 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CDI78235.1 - 0.034 14.1 0.2 0.061 13.2 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 CDI78235.1 - 0.034 14.1 0.2 0.093 12.6 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC2_membrane_3 PF12698.2 CDI78235.1 - 0.068 12.1 0.6 0.11 11.4 0.4 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Dynamin_N PF00350.18 CDI78235.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Dynamin family ArgK PF03308.11 CDI78235.1 - 0.26 10.0 0.2 18 3.9 0.1 2.4 2 0 0 2 2 2 0 ArgK protein AAA_23 PF13476.1 CDI78235.1 - 0.27 11.5 0.0 0.43 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CDI78235.1 - 0.29 10.5 1.2 22 4.3 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein SURF1 PF02104.10 CDI78237.1 - 4.7e-29 101.7 0.3 3.3e-17 63.0 0.0 3.2 2 1 0 2 2 2 2 SURF1 family Med3 PF11593.3 CDI78237.1 - 0.48 9.5 10.4 0.01 15.0 1.8 1.9 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal TB2_DP1_HVA22 PF03134.14 CDI78238.1 - 4.6e-14 51.9 2.3 6.7e-14 51.4 1.6 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Cpn60_TCP1 PF00118.19 CDI78239.1 - 6.4e-116 387.8 2.8 2.1e-115 386.1 2.0 1.7 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family RhodobacterPufX PF11511.3 CDI78239.1 - 0.017 14.5 2.1 0.055 12.8 1.2 2.0 2 0 0 2 2 2 0 Intrinsic membrane protein PufX B12-binding PF02310.14 CDI78239.1 - 0.035 13.9 0.3 0.33 10.8 0.1 2.5 2 0 0 2 2 2 0 B12 binding domain Pex14_N PF04695.8 CDI78240.1 - 0.096 12.7 36.6 0.12 12.3 3.3 4.9 5 0 0 5 5 5 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ycf1 PF05758.7 CDI78240.1 - 0.17 9.5 15.8 0.053 11.2 2.0 2.2 2 0 0 2 2 2 0 Ycf1 zf-DHHC PF01529.15 CDI78240.1 - 0.56 9.5 5.7 3.5 6.9 0.7 2.7 2 1 0 2 2 2 0 DHHC palmitoyltransferase Suf PF05843.9 CDI78240.1 - 1.1 8.9 25.0 0.031 14.0 3.7 2.7 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI78240.1 - 2.4 6.2 56.7 0.012 13.9 15.8 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 ATP_synt_I PF03899.10 CDI78240.1 - 2.9 8.0 6.2 0.8 9.8 1.2 2.3 2 0 0 2 2 2 0 ATP synthase I chain Metallophos PF00149.23 CDI78241.1 - 5e-05 22.7 0.2 0.0001 21.7 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPR_2 PF13041.1 CDI78242.1 - 8e-51 169.8 1.4 6.4e-11 42.0 0.0 9.1 6 3 3 9 9 9 8 PPR repeat family PPR_3 PF13812.1 CDI78242.1 - 7.4e-25 85.1 14.8 0.0011 19.0 0.0 12.2 13 0 0 13 13 13 6 Pentatricopeptide repeat domain PPR_1 PF12854.2 CDI78242.1 - 8.3e-24 82.7 4.2 0.00034 20.0 0.0 9.1 10 0 0 10 10 10 6 PPR repeat PPR PF01535.15 CDI78242.1 - 5.7e-23 79.2 20.5 3.7e-05 23.4 0.0 10.3 12 0 0 12 12 12 6 PPR repeat HCNGP PF07818.8 CDI78243.1 - 3.8e-15 55.6 0.1 8.6e-15 54.5 0.1 1.7 1 1 0 1 1 1 1 HCNGP-like protein Peptidase_C1 PF00112.18 CDI78244.1 - 7.2e-32 111.0 6.1 4.3e-29 101.9 0.8 4.7 1 1 2 3 3 3 2 Papain family cysteine protease CathepsinC_exc PF08773.6 CDI78244.1 - 0.00032 20.8 0.0 0.00032 20.8 0.0 2.2 2 0 0 2 2 2 1 Cathepsin C exclusion domain Mem_trans PF03547.13 CDI78244.1 - 0.26 9.5 0.9 0.33 9.2 0.6 1.2 1 0 0 1 1 1 0 Membrane transport protein Ycf1 PF05758.7 CDI78244.1 - 0.97 7.0 16.1 1.4 6.5 11.2 1.2 1 0 0 1 1 1 0 Ycf1 EIF4E-T PF10477.4 CDI78244.1 - 2.4 6.8 26.3 4.7 5.9 18.2 1.4 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E AAA_23 PF13476.1 CDI78244.1 - 8 6.7 17.7 12 6.1 11.7 1.9 2 0 0 2 2 2 0 AAA domain YjgP_YjgQ PF03739.9 CDI78244.1 - 8.1 5.0 9.0 13 4.4 6.2 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Med15 PF09606.5 CDI78245.1 - 0.0082 14.4 58.4 0.012 13.8 40.5 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal TSP_1 PF00090.14 CDI78245.1 - 0.013 15.5 8.5 0.013 15.5 5.9 4.9 4 2 0 4 4 4 0 Thrombospondin type 1 domain SprA-related PF12118.3 CDI78245.1 - 0.025 13.9 28.0 0.053 12.8 19.4 1.6 1 0 0 1 1 1 0 SprA-related family PgaD PF13994.1 CDI78245.1 - 0.28 10.6 0.1 0.28 10.6 0.0 2.8 1 1 0 2 2 2 0 PgaD-like protein Serinc PF03348.10 CDI78245.1 - 1.3 7.6 5.8 2.3 6.8 4.0 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) DcpS_C PF11969.3 CDI78246.1 - 1.5e-06 28.4 0.2 0.00022 21.4 0.0 2.7 3 0 0 3 3 3 1 Scavenger mRNA decapping enzyme C-term binding CpXC PF14353.1 CDI78246.1 - 0.089 12.7 0.5 4.1 7.3 0.2 2.5 2 0 0 2 2 2 0 CpXC protein Ribosomal_60s PF00428.14 CDI78246.1 - 0.87 10.0 8.2 2.3 8.6 5.7 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Macoilin PF09726.4 CDI78247.1 - 1.7 6.8 15.0 1.9 6.6 10.4 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF4551 PF15087.1 CDI78247.1 - 4.9 5.3 17.0 5.5 5.2 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Nuc_sug_transp PF04142.10 CDI78249.1 - 5.6e-82 274.5 8.3 5.6e-82 274.5 5.8 1.5 2 0 0 2 2 2 1 Nucleotide-sugar transporter EmrE PF13536.1 CDI78249.1 - 4.7e-08 33.2 4.4 4.7e-08 33.2 3.0 3.3 3 2 0 3 3 3 1 Multidrug resistance efflux transporter TPT PF03151.11 CDI78249.1 - 5.5e-07 29.3 16.3 6.8e-06 25.8 2.8 2.8 2 1 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 CDI78249.1 - 6.7e-05 21.9 6.4 0.00027 19.9 4.4 1.9 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 CDI78249.1 - 0.00018 21.5 8.8 0.00018 21.5 6.1 2.8 2 1 0 2 2 2 1 EamA-like transporter family LCCL PF03815.14 CDI78250.1 - 7.1e-32 109.2 0.4 3.2e-17 62.2 0.0 2.3 1 1 1 2 2 2 2 LCCL domain DUF3138 PF11336.3 CDI78251.1 - 1.9 6.5 11.5 3 5.9 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TFIIA PF03153.8 CDI78251.1 - 3.7 7.3 7.5 4.3 7.1 5.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LCCL PF03815.14 CDI78252.1 - 5e-11 42.4 0.0 1.2e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 LCCL domain SRCR PF00530.13 CDI78252.1 - 1.8e-09 37.8 4.7 1.7e-08 34.6 0.5 2.8 2 2 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.1 CDI78252.1 - 1.1e-05 25.6 0.9 2e-05 24.7 0.1 1.8 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Ribosomal_L32e PF01655.13 CDI78253.1 - 3e-45 152.7 2.1 5.1e-45 152.0 1.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L32 Pkinase PF00069.20 CDI78254.1 - 8.7e-37 126.6 0.0 2.8e-35 121.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78254.1 - 1.4e-19 70.1 0.0 2.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI78254.1 - 1.1e-08 34.4 0.0 1.6e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CDI78254.1 - 0.00011 22.0 0.2 0.00027 20.7 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDI78254.1 - 0.084 12.4 0.0 0.17 11.4 0.0 1.4 2 0 0 2 2 2 0 Choline/ethanolamine kinase MMR_HSR1 PF01926.18 CDI78256.1 - 2.7e-14 53.1 0.0 8.2e-14 51.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDI78256.1 - 0.0024 17.1 0.0 0.0048 16.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDI78256.1 - 0.0031 16.9 0.0 1 8.7 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 CDI78256.1 - 0.0092 15.8 0.0 0.13 12.0 0.0 2.8 3 0 0 3 3 3 1 Dynamin family DUF258 PF03193.11 CDI78256.1 - 0.033 13.3 0.0 0.16 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ASFV_J13L PF05568.6 CDI78258.1 - 0.15 11.5 1.4 0.37 10.3 0.9 1.7 1 0 0 1 1 1 0 African swine fever virus J13L protein AIF_C PF14721.1 CDI78262.1 - 0.011 15.9 8.9 0.013 15.7 6.1 1.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Zip PF02535.17 CDI78262.1 - 0.014 14.4 11.5 0.014 14.4 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Glyco_hydro_85 PF03644.8 CDI78262.1 - 0.021 13.9 4.2 0.021 13.9 2.9 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 ECIST_Cterm PF14784.1 CDI78262.1 - 0.021 14.7 9.0 0.024 14.5 6.2 1.1 1 0 0 1 1 1 0 C-terminal domain of the ECSIT protein PBP1_TM PF14812.1 CDI78262.1 - 0.047 14.0 0.8 0.051 13.8 0.5 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Folate_carrier PF01770.13 CDI78262.1 - 0.081 11.4 8.9 0.08 11.4 6.1 1.0 1 0 0 1 1 1 0 Reduced folate carrier DUF912 PF06024.7 CDI78262.1 - 0.12 12.4 5.4 0.17 11.9 3.8 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Pex14_N PF04695.8 CDI78262.1 - 0.14 12.2 16.2 0.13 12.2 11.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FNIP_N PF14636.1 CDI78262.1 - 0.2 12.1 11.0 0.24 11.8 7.7 1.1 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus CD20 PF04103.10 CDI78262.1 - 0.25 11.2 4.1 0.31 10.9 2.8 1.2 1 0 0 1 1 1 0 CD20-like family Pap_E4 PF02711.9 CDI78262.1 - 0.28 12.0 11.1 0.31 11.8 7.7 1.1 1 0 0 1 1 1 0 E4 protein SelP_N PF04592.9 CDI78262.1 - 0.32 10.3 17.6 0.34 10.2 12.2 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1764 PF08576.5 CDI78262.1 - 0.33 11.7 10.2 0.36 11.6 7.1 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) FAM176 PF14851.1 CDI78262.1 - 0.45 10.1 4.9 0.49 10.0 3.4 1.1 1 0 0 1 1 1 0 FAM176 family MecA PF05389.7 CDI78262.1 - 0.48 9.9 9.3 0.49 9.9 6.4 1.0 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Peroxin-13_N PF04088.8 CDI78262.1 - 0.56 10.1 4.6 0.59 10.0 3.2 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Glt_symporter PF03616.9 CDI78262.1 - 0.56 8.6 3.9 0.58 8.5 2.7 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter TraH_2 PF06871.6 CDI78262.1 - 0.62 9.4 4.0 0.69 9.3 2.7 1.0 1 0 0 1 1 1 0 TraH_2 EIIBC-GUT_N PF03612.9 CDI78262.1 - 0.75 9.3 10.0 0.78 9.3 6.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DDHD PF02862.12 CDI78262.1 - 0.87 9.3 10.9 0.99 9.1 7.5 1.0 1 0 0 1 1 1 0 DDHD domain DcuC PF03606.10 CDI78262.1 - 0.89 7.7 2.8 0.92 7.6 2.0 1.2 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Peptidase_U57 PF05582.7 CDI78262.1 - 0.92 8.4 9.7 0.97 8.3 6.7 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Cryptochrome_C PF12546.3 CDI78262.1 - 0.92 10.2 15.5 1.4 9.6 10.8 1.3 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal Glyco_transf_15 PF01793.11 CDI78262.1 - 1.1 8.1 10.5 1.2 7.9 7.3 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase FAM60A PF15396.1 CDI78262.1 - 1.2 8.8 8.3 1.3 8.7 5.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A FemAB PF02388.11 CDI78262.1 - 1.2 7.6 13.0 1.3 7.6 9.0 1.0 1 0 0 1 1 1 0 FemAB family HD-ZIP_N PF04618.7 CDI78262.1 - 1.3 9.5 9.6 1.6 9.2 6.6 1.1 1 0 0 1 1 1 0 HD-ZIP protein N terminus FimP PF09766.4 CDI78262.1 - 1.3 7.9 19.9 1.5 7.8 13.8 1.1 1 0 0 1 1 1 0 Fms-interacting protein DUF3381 PF11861.3 CDI78262.1 - 1.4 8.3 11.2 1.5 8.2 7.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Tim54 PF11711.3 CDI78262.1 - 1.4 7.4 7.7 1.5 7.3 5.3 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SprA-related PF12118.3 CDI78262.1 - 1.5 8.1 30.6 1.6 7.9 21.2 1.0 1 0 0 1 1 1 0 SprA-related family Spt5_N PF11942.3 CDI78262.1 - 1.5 9.5 11.1 1.7 9.3 7.7 1.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Nucleoside_tran PF01733.13 CDI78262.1 - 1.5 7.9 7.1 1.6 7.8 5.0 1.0 1 0 0 1 1 1 0 Nucleoside transporter Spore_coat_CotO PF14153.1 CDI78262.1 - 1.5 8.2 17.6 1.6 8.1 12.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF2370 PF10176.4 CDI78262.1 - 1.6 8.0 6.4 1.6 7.9 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) GOLD_2 PF13897.1 CDI78262.1 - 1.6 8.9 4.6 1.9 8.7 3.2 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF4045 PF13254.1 CDI78262.1 - 1.8 7.7 10.8 1.9 7.6 7.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Macoilin PF09726.4 CDI78262.1 - 1.8 6.7 13.8 1.9 6.6 9.6 1.0 1 0 0 1 1 1 0 Transmembrane protein Spc24 PF08286.6 CDI78262.1 - 1.9 8.1 10.6 2.3 7.9 7.3 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 RIC3 PF15361.1 CDI78262.1 - 2 8.6 13.2 2.2 8.5 9.1 1.1 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 RR_TM4-6 PF06459.7 CDI78262.1 - 2.1 8.1 11.5 2.2 8.0 8.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Kei1 PF08552.6 CDI78262.1 - 2.1 7.9 8.5 2.3 7.8 5.9 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 AUX_IAA PF02309.11 CDI78262.1 - 2.1 8.0 10.5 2.3 7.9 7.3 1.1 1 0 0 1 1 1 0 AUX/IAA family Gti1_Pac2 PF09729.4 CDI78262.1 - 2.2 8.1 8.8 2.3 8.0 6.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family SeqA PF03925.8 CDI78262.1 - 2.4 7.8 11.3 2.6 7.7 7.8 1.1 1 0 0 1 1 1 0 SeqA protein Baculo_PP31 PF05311.6 CDI78262.1 - 2.4 7.3 12.8 2.6 7.2 8.9 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Peptidase_S49_N PF08496.5 CDI78262.1 - 2.5 7.8 10.5 2.9 7.6 7.2 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OATP PF03137.15 CDI78262.1 - 2.8 5.8 12.6 2.9 5.8 8.7 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4011 PF13195.1 CDI78262.1 - 3 7.8 6.6 3.3 7.7 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) HCO3_cotransp PF00955.16 CDI78262.1 - 3.2 6.2 5.6 3.3 6.2 3.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family CbtA PF09490.5 CDI78262.1 - 3.2 6.9 7.4 3.4 6.9 5.1 1.0 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) GPCR_chapero_1 PF11904.3 CDI78262.1 - 3.3 6.7 11.3 3.4 6.7 7.8 1.0 1 0 0 1 1 1 0 GPCR-chaperone DUF3984 PF13136.1 CDI78262.1 - 3.4 6.8 12.9 3.5 6.7 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Tom37_C PF11801.3 CDI78262.1 - 3.5 7.4 13.2 3.8 7.3 9.1 1.0 1 0 0 1 1 1 0 Tom37 C-terminal domain DUF3464 PF11947.3 CDI78262.1 - 3.6 7.0 9.9 3.9 6.9 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) BORG_CEP PF14957.1 CDI78262.1 - 3.8 8.4 8.2 4.1 8.3 5.7 1.1 1 0 0 1 1 1 0 Cdc42 effector Hid1 PF12722.2 CDI78262.1 - 3.9 5.0 12.2 4 5.0 8.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DDRGK PF09756.4 CDI78262.1 - 4.5 6.6 18.2 5.3 6.3 12.6 1.1 1 0 0 1 1 1 0 DDRGK domain HGTP_anticodon2 PF12745.2 CDI78262.1 - 4.6 6.3 11.6 5.2 6.1 8.0 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CPSF100_C PF13299.1 CDI78262.1 - 4.7 7.3 9.9 4.9 7.3 6.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spc7_N PF15402.1 CDI78262.1 - 4.8 5.0 16.0 4.8 5.0 11.1 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF4175 PF13779.1 CDI78262.1 - 5 4.7 35.1 4.8 4.7 24.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ycf1 PF05758.7 CDI78262.1 - 5 4.7 12.3 5.2 4.6 8.5 1.0 1 0 0 1 1 1 0 Ycf1 Neur_chan_memb PF02932.11 CDI78262.1 - 5 6.9 10.4 5.5 6.7 7.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4484 PF14831.1 CDI78262.1 - 5 7.1 9.1 5.4 7.0 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF2547 PF10818.3 CDI78262.1 - 5.2 7.7 28.8 6.4 7.4 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2547) Suf PF05843.9 CDI78262.1 - 5.4 6.6 17.3 6.6 6.3 12.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Vma12 PF11712.3 CDI78262.1 - 5.8 6.6 7.7 6.6 6.4 5.4 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Pex16 PF08610.5 CDI78262.1 - 5.8 5.8 10.5 6.2 5.7 7.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) NicO PF03824.11 CDI78262.1 - 6.4 6.0 6.8 7 5.8 4.7 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein RED_N PF07808.8 CDI78262.1 - 6.6 5.8 17.4 7 5.7 12.1 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Presenilin PF01080.12 CDI78262.1 - 6.7 5.4 7.6 7 5.3 5.3 1.0 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.8 CDI78262.1 - 7.3 5.4 10.1 7.6 5.4 7.0 1.0 1 0 0 1 1 1 0 Otopetrin R_equi_Vir PF05526.6 CDI78262.1 - 7.4 6.1 6.6 8.1 6.0 4.6 1.1 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Gag_spuma PF03276.9 CDI78262.1 - 7.4 4.7 23.1 7.7 4.7 16.0 1.0 1 0 0 1 1 1 0 Spumavirus gag protein BRF1 PF07741.8 CDI78262.1 - 7.5 6.8 12.2 11 6.3 8.4 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF2347 PF09804.4 CDI78262.1 - 7.6 5.7 9.3 7.3 5.7 6.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF3675 PF12428.3 CDI78262.1 - 7.6 6.8 7.4 9 6.5 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) DUF2126 PF09899.4 CDI78262.1 - 7.7 4.4 11.8 8 4.3 8.2 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Endonuc_Holl PF10107.4 CDI78262.1 - 7.7 6.1 12.3 8.5 6.0 8.5 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF3260 PF11658.3 CDI78262.1 - 8.2 4.4 12.3 7.7 4.5 8.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Serinc PF03348.10 CDI78262.1 - 8.3 5.0 11.3 8.5 4.9 7.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.10 CDI78262.1 - 8.4 6.4 8.9 9.1 6.3 6.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Sec62 PF03839.11 CDI78262.1 - 9.3 5.5 9.5 9.8 5.5 6.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PcfK PF14058.1 CDI78262.1 - 9.5 6.3 17.3 11 6.1 12.0 1.1 1 0 0 1 1 1 0 PcfK-like protein YABBY PF04690.8 CDI78262.1 - 9.7 6.4 12.8 10 6.3 8.9 1.1 1 0 0 1 1 1 0 YABBY protein Bud13 PF09736.4 CDI78262.1 - 9.8 6.4 17.6 12 6.1 12.2 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex SIR2 PF02146.12 CDI78263.1 - 5.9e-06 26.1 9.3 0.015 15.0 0.0 4.2 3 1 1 4 4 4 3 Sir2 family Rav1p_C PF12234.3 CDI78267.1 - 3.3e-21 75.1 6.5 8.2e-16 57.3 0.2 4.1 4 0 0 4 4 4 3 RAVE protein 1 C terminal Zip PF02535.17 CDI78267.1 - 7 5.5 35.0 0.0031 16.5 0.6 5.2 5 0 0 5 5 5 0 ZIP Zinc transporter Hid1 PF12722.2 CDI78268.1 - 6.3 4.3 4.6 10 3.6 3.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Surface_antigen PF11054.3 CDI78270.1 - 0.013 14.9 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI78271.1 - 3.9e-47 160.7 4.0 4.8e-47 160.4 2.8 1.1 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen BMC PF00936.14 CDI78271.1 - 0.05 13.2 2.3 0.059 13.0 0.0 2.3 3 0 0 3 3 3 0 BMC domain Parecho_VpG PF06344.6 CDI78271.1 - 0.18 11.7 3.4 1.2 9.1 0.3 2.6 2 0 0 2 2 2 0 Parechovirus Genome-linked protein Asp_protease PF09668.5 CDI78272.1 - 1.1e-50 170.3 0.0 1.6e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 CDI78272.1 - 4e-10 40.0 0.0 1.5e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease ubiquitin PF00240.18 CDI78272.1 - 4e-08 32.5 0.0 9.3e-08 31.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family gag-asp_proteas PF13975.1 CDI78272.1 - 4.7e-08 32.7 0.1 7.9e-07 28.8 0.0 2.7 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 CDI78272.1 - 2.1e-07 30.9 0.0 3.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.3 CDI78272.1 - 4.9e-05 22.9 0.0 0.0001 21.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP PF00077.15 CDI78272.1 - 0.00012 21.9 0.0 0.00038 20.3 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease DUF853 PF05872.7 CDI78273.1 - 0.18 10.1 0.1 0.28 9.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) ENTH PF01417.15 CDI78274.1 - 8.8e-26 90.2 0.0 1.3e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 ENTH domain DUF572 PF04502.8 CDI78274.1 - 0.67 9.1 2.8 1.4 8.0 1.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) V_ATPase_I PF01496.14 CDI78277.1 - 1.7e-160 535.4 5.1 9.8e-142 473.4 8.1 2.2 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family zf-C3HC4_3 PF13920.1 CDI78278.1 - 0.0086 15.7 11.9 0.017 14.7 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI78278.1 - 0.043 13.5 11.0 0.13 12.0 7.7 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDI78278.1 - 0.091 12.7 14.3 0.19 11.8 9.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI78278.1 - 0.24 11.2 12.6 0.54 10.1 8.8 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.1 CDI78278.1 - 8.4 6.3 10.7 25 4.8 7.4 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING PP2C PF00481.16 CDI78279.1 - 1.2e-05 24.8 0.1 4.1e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Protein phosphatase 2C Chorismate_synt PF01264.16 CDI78279.1 - 0.0012 17.3 0.3 0.0017 16.8 0.2 1.2 1 0 0 1 1 1 1 Chorismate synthase Macoilin PF09726.4 CDI78279.1 - 0.29 9.3 11.7 0.35 9.1 8.1 1.2 1 0 0 1 1 1 0 Transmembrane protein SOBP PF15279.1 CDI78279.1 - 0.92 9.8 9.9 0.095 13.0 0.5 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein CAF-1_p150 PF11600.3 CDI78279.1 - 5.8 6.2 8.8 12 5.1 6.1 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF515 PF04415.7 CDI78279.1 - 8.1 4.5 6.0 11 4.1 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Epimerase_Csub PF13950.1 CDI78281.1 - 1e-25 89.4 0.0 1.7e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Epimerase PF01370.16 CDI78281.1 - 3.5e-23 82.2 0.0 4.3e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CDI78281.1 - 0.00017 20.5 0.0 0.00021 20.2 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 CDI78281.1 - 0.0068 15.3 0.0 0.0092 14.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 CDI78281.1 - 0.15 10.7 0.0 0.3 9.7 0.0 1.5 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PAT1 PF09770.4 CDI78283.1 - 3.2 5.8 61.4 4 5.5 42.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2217 PF10265.4 CDI78283.1 - 3.3 6.3 7.5 4.9 5.7 5.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Med15 PF09606.5 CDI78284.1 - 1.2 7.1 19.4 1.4 7.0 13.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CPW_WPC PF09717.5 CDI78285.1 - 2.3e-11 44.1 8.6 0.00039 20.9 0.0 4.0 3 1 0 3 3 3 3 Plasmodium falciparum domain of unknown function (CPW_WPC) DUF2547 PF10818.3 CDI78285.1 - 0.017 15.6 8.7 0.43 11.2 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) Phostensin_N PF13916.1 CDI78285.1 - 0.97 9.4 10.5 3.9 7.5 0.3 2.4 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal SLBP_RNA_bind PF15247.1 CDI78286.1 - 3.7e-18 65.0 3.0 3.7e-18 65.0 2.1 3.3 3 0 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain SR-25 PF10500.4 CDI78286.1 - 0.00023 20.6 15.7 0.00023 20.6 10.9 3.7 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein THRAP3_BCLAF1 PF15440.1 CDI78287.1 - 0.0018 17.0 14.2 0.0018 17.0 9.9 4.7 2 1 2 4 4 4 1 THRAP3/BCLAF1 family GBP PF02263.14 CDI78288.1 - 5e-11 42.1 0.9 5e-11 42.1 0.7 3.2 3 1 0 3 3 3 1 Guanylate-binding protein, N-terminal domain DUF3357 PF11837.3 CDI78288.1 - 0.12 12.2 3.4 0.21 11.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) Spt20 PF12090.3 CDI78288.1 - 1.3 8.3 21.3 6 6.1 0.2 3.5 3 0 0 3 3 3 0 Spt20 family SID-1_RNA_chan PF13965.1 CDI78288.1 - 2.1 6.3 5.6 2.5 6.1 0.2 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 FAM176 PF14851.1 CDI78288.1 - 3.5 7.2 10.1 0.13 11.8 0.2 3.0 3 1 0 3 3 3 0 FAM176 family OmpH PF03938.9 CDI78293.1 - 0.0026 17.6 16.9 0.0026 17.6 11.7 6.6 5 2 1 6 6 6 1 Outer membrane protein (OmpH-like) TFIIA PF03153.8 CDI78294.1 - 1.7 8.4 9.9 2.1 8.1 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Gar1 PF04410.9 CDI78295.1 - 3e-24 85.2 0.0 6.7e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Proteasom_Rpn13 PF04683.8 CDI78295.1 - 6.3e-10 39.0 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Activator_LAG-3 PF11498.3 CDI78295.1 - 0.0049 15.6 5.6 0.0049 15.6 3.9 2.2 2 0 0 2 2 2 2 Transcriptional activator LAG-3 UCH PF00443.24 CDI78297.1 - 2.6e-34 118.5 0.0 2.6e-34 118.5 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDI78297.1 - 2.3e-12 46.9 0.0 2.3e-12 46.9 0.0 3.8 3 2 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Secretin_N_2 PF07655.8 CDI78297.1 - 0.27 11.6 11.6 0.5 10.7 3.0 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain Dala_Dala_lig_N PF01820.16 CDI78297.1 - 0.28 11.4 9.8 0.83 9.9 0.2 3.4 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus MFS_1 PF07690.11 CDI78298.1 - 7.9e-23 80.7 48.1 1.9e-19 69.6 12.3 3.3 1 1 1 3 3 3 3 Major Facilitator Superfamily OATP PF03137.15 CDI78298.1 - 4.4e-10 38.2 17.3 5e-06 24.8 0.2 4.2 3 1 1 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family Ribosomal_S4 PF00163.14 CDI78299.1 - 1.2e-24 86.5 3.8 2e-24 85.7 2.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 CDI78299.1 - 3.8e-13 48.6 2.6 4.3e-13 48.4 0.3 2.2 2 0 0 2 2 2 1 S4 domain DOT1 PF08123.8 CDI78300.1 - 4.3e-05 22.9 0.0 7.4e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 EGF_2 PF07974.8 CDI78301.1 - 2.2e-17 62.9 195.1 3.6e-05 23.8 9.6 11.3 11 1 0 11 11 11 8 EGF-like domain hEGF PF12661.2 CDI78301.1 - 0.00071 19.4 3.9 0.00071 19.4 2.7 10.2 9 0 0 9 9 9 4 Human growth factor-like EGF CLAG PF03805.8 CDI78303.1 - 0.61 7.3 0.0 2.7 5.2 0.0 1.9 3 0 0 3 3 3 0 Cytoadherence-linked asexual protein Ank_2 PF12796.2 CDI78305.1 - 2.5e-60 200.7 8.7 3.2e-19 69.0 0.1 6.8 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 CDI78305.1 - 1.6e-38 128.6 7.7 0.0013 18.4 0.0 11.1 11 0 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.1 CDI78305.1 - 5.4e-35 118.6 1.9 2.8e-06 27.3 0.0 8.1 5 1 3 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDI78305.1 - 3.8e-33 113.2 0.7 7e-06 26.4 0.0 7.6 5 3 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI78305.1 - 1.2e-28 96.2 0.2 0.027 14.7 0.0 10.2 10 0 0 10 10 10 7 Ankyrin repeat TFIIA PF03153.8 CDI78305.1 - 0.1 12.4 21.4 0.15 11.8 3.7 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Trep_dent_lipo PF09710.5 CDI78305.1 - 0.84 8.2 0.8 1.4 7.5 0.6 1.2 1 0 0 1 1 1 0 Treponema clustered lipoprotein (Trep_dent_lipo) AAA_23 PF13476.1 CDI78305.1 - 4.3 7.5 8.1 1.7 8.9 1.9 2.6 3 0 0 3 3 3 0 AAA domain 5_nucleotid_C PF02872.13 CDI78306.1 - 4.2e-35 121.0 0.0 1e-34 119.7 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 CDI78306.1 - 0.0012 18.2 0.6 0.016 14.6 0.4 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Not3 PF04065.10 CDI78307.1 - 0.23 10.7 8.3 0.4 9.9 5.7 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF342 PF03961.8 CDI78307.1 - 0.45 8.8 1.2 0.7 8.2 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Occludin_ELL PF07303.8 CDI78307.1 - 2.3 8.9 11.6 0.082 13.6 3.0 2.3 2 0 0 2 2 2 0 Occludin homology domain ELO PF01151.13 CDI78308.1 - 0.01 15.1 1.7 0.028 13.7 1.2 1.8 1 0 0 1 1 1 0 GNS1/SUR4 family Fcf1 PF04900.7 CDI78309.1 - 7.1e-30 103.0 1.6 1.4e-29 102.1 0.1 1.9 2 0 0 2 2 2 1 Fcf1 DUF3323 PF11796.3 CDI78309.1 - 0.029 13.7 0.1 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) Mitochondr_Som1 PF11093.3 CDI78309.1 - 0.066 13.0 0.3 2.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial export protein Som1 YpzI PF14140.1 CDI78309.1 - 0.076 12.5 1.2 0.31 10.5 0.6 2.1 1 1 1 2 2 2 0 YpzI-like protein DUF1183 PF06682.7 CDI78310.1 - 0.0019 17.8 0.0 0.0022 17.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Sec3_C_2 PF15278.1 CDI78310.1 - 0.056 13.5 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Sec3 exocyst complex subunit UPF0561 PF10573.4 CDI78310.1 - 0.1 12.4 1.5 0.15 11.9 1.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 DUF3972 PF13118.1 CDI78311.1 - 0.017 15.2 4.4 0.1 12.6 2.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3972) Katanin_con80 PF13925.1 CDI78311.1 - 0.017 14.8 4.6 1.7 8.3 0.2 2.3 2 0 0 2 2 2 0 con80 domain of Katanin DUF745 PF05335.8 CDI78311.1 - 0.48 9.9 11.7 2 7.9 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) V_ATPase_I PF01496.14 CDI78311.1 - 0.79 7.5 9.3 1.3 6.8 5.9 1.5 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.11 CDI78311.1 - 0.95 7.9 5.0 1.2 7.6 3.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SurA_N PF09312.6 CDI78311.1 - 1.2 9.0 7.4 0.3 10.9 2.9 1.7 2 0 0 2 2 2 0 SurA N-terminal domain TMPIT PF07851.8 CDI78311.1 - 1.6 7.7 5.9 2.2 7.2 4.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF334 PF03904.8 CDI78311.1 - 1.8 7.8 7.9 3.9 6.7 5.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF334) Microtub_assoc PF07989.6 CDI78311.1 - 2.7 7.8 11.3 11 5.9 2.4 3.4 3 1 0 3 3 3 0 Microtubule associated Fzo_mitofusin PF04799.8 CDI78314.1 - 7.1 5.9 8.2 15 4.9 1.1 2.8 2 0 0 2 2 2 0 fzo-like conserved region Ank_4 PF13637.1 CDI78315.1 - 3.4e-15 56.0 0.8 0.023 15.1 0.0 5.1 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI78315.1 - 7.7e-15 55.0 0.3 2.9e-07 30.7 0.1 3.7 4 0 0 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 CDI78315.1 - 9.2e-15 53.6 0.1 0.00061 19.4 0.1 5.8 6 1 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.1 CDI78315.1 - 9e-11 41.6 2.6 0.61 10.4 0.0 5.5 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI78315.1 - 1.9e-06 27.5 2.6 0.17 12.1 0.1 5.6 6 0 0 6 6 6 1 Ankyrin repeat HR1 PF02185.11 CDI78315.1 - 0.09 12.5 0.2 0.28 10.9 0.1 1.9 1 0 0 1 1 1 0 Hr1 repeat DUF775 PF05603.7 CDI78317.1 - 0.29 10.6 5.2 0.057 12.9 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF775) Adap_comp_sub PF00928.16 CDI78319.1 - 1.5e-64 217.6 0.0 2.9e-54 183.9 0.0 2.2 1 1 1 2 2 2 2 Adaptor complexes medium subunit family DUF2360 PF10152.4 CDI78319.1 - 0.63 10.3 2.7 0.65 10.2 0.9 1.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) PCI PF01399.22 CDI78322.1 - 6e-15 55.4 0.5 7e-14 52.0 0.0 2.5 2 0 0 2 2 2 1 PCI domain Not3 PF04065.10 CDI78322.1 - 0.027 13.7 3.4 0.18 11.0 0.3 2.5 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Rep_3 PF01051.16 CDI78322.1 - 0.32 10.5 3.3 0.84 9.1 2.0 1.8 2 0 0 2 2 2 0 Initiator Replication protein PIGA PF08288.7 CDI78323.1 - 1.7e-38 130.8 3.6 1.7e-38 130.8 2.5 1.8 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_trans_4_4 PF13579.1 CDI78323.1 - 8.5e-13 48.7 0.5 1.6e-11 44.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.15 CDI78323.1 - 3.2e-11 42.9 0.0 5.7e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CDI78323.1 - 5.6e-10 39.2 4.2 1.1e-09 38.3 2.9 1.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.1 CDI78323.1 - 1.1e-07 31.7 2.2 1.8e-07 31.0 1.5 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 CDI78323.1 - 6.4e-06 26.3 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 CDI78323.1 - 0.00027 21.1 0.0 0.00048 20.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 CKS PF01111.14 CDI78324.1 - 1.5e-19 69.6 0.0 4.3e-19 68.1 0.0 1.9 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Mur_ligase_M PF08245.7 CDI78324.1 - 0.036 14.1 0.0 9.4 6.2 0.0 2.2 2 0 0 2 2 2 0 Mur ligase middle domain Macro PF01661.16 CDI78324.1 - 0.041 13.7 0.0 15 5.5 0.0 2.7 2 1 1 3 3 3 0 Macro domain MeMO_Hyd_G PF02964.11 CDI78324.1 - 0.055 13.3 0.1 12 5.8 0.0 2.1 2 0 0 2 2 2 0 Methane monooxygenase, hydrolase gamma chain PaRep2b PF07775.6 CDI78324.1 - 0.091 10.9 0.3 7.4 4.6 0.0 2.1 2 0 0 2 2 2 0 PaRep2b protein Borrelia_rep PF03183.8 CDI78324.1 - 1.5 8.7 3.7 32 4.5 0.2 2.4 2 0 0 2 2 2 0 Borrelia repeat protein Ribosomal_60s PF00428.14 CDI78325.1 - 0.0089 16.4 7.5 0.015 15.7 5.2 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein TT_ORF2 PF02957.10 CDI78325.1 - 8 7.1 12.0 1.3 9.7 1.6 2.3 1 1 1 2 2 2 0 TT viral ORF2 DUF4367 PF14285.1 CDI78326.1 - 0.49 9.6 0.0 0.49 9.6 0.0 4.5 6 1 1 7 7 7 0 Domain of unknown function (DUF4367) WD40 PF00400.27 CDI78328.1 - 2.4e-26 90.6 14.3 1.4e-06 27.9 0.5 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat Med15 PF09606.5 CDI78328.1 - 0.0087 14.3 21.8 0.015 13.5 15.1 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal FimP PF09766.4 CDI78328.1 - 0.15 11.0 6.2 0.11 11.5 1.6 2.0 2 0 0 2 2 2 0 Fms-interacting protein Suf PF05843.9 CDI78328.1 - 0.23 11.1 5.0 0.39 10.4 3.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Rhomboid PF01694.17 CDI78331.1 - 4.6e-25 88.3 14.9 4.6e-25 88.3 10.3 2.1 2 0 0 2 2 2 1 Rhomboid family RCC1 PF00415.13 CDI78331.1 - 8.7e-09 35.4 1.6 0.00043 20.4 0.1 5.0 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI78331.1 - 0.13 11.9 24.0 0.18 11.4 0.1 6.0 6 0 0 6 6 6 0 Regulator of chromosome condensation (RCC1) repeat OmpH PF03938.9 CDI78331.1 - 0.15 12.0 28.3 0.26 11.2 9.2 2.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) COX6A PF02046.10 CDI78331.1 - 1.4 8.8 5.9 15 5.4 0.1 2.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIa SPX PF03105.14 CDI78331.1 - 7.4 6.2 13.3 2.2 8.0 0.5 2.4 1 1 1 2 2 2 0 SPX domain Corona_nucleoca PF00937.13 CDI78334.1 - 0.88 8.4 7.8 0.96 8.3 5.4 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Atrophin-1 PF03154.10 CDI78334.1 - 2.5 6.1 8.1 2.4 6.2 5.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family Red1 PF07964.6 CDI78334.1 - 7 4.6 7.9 8.2 4.4 5.5 1.0 1 0 0 1 1 1 0 Rec10 / Red1 DMP1 PF07263.6 CDI78334.1 - 9.5 4.8 26.6 8.2 5.0 17.2 1.6 2 0 0 2 2 2 0 Dentin matrix protein 1 (DMP1) SET PF00856.23 CDI78335.1 - 5e-21 75.6 0.0 5e-21 75.6 0.0 5.3 4 2 0 4 4 4 1 SET domain AMP-binding PF00501.23 CDI78338.1 - 6.8e-18 64.2 0.0 9.3e-18 63.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Hep_59 PF07052.6 CDI78340.1 - 5.4e-20 71.6 2.3 5.4e-20 71.6 1.6 2.4 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 Eaf7 PF07904.8 CDI78340.1 - 0.11 12.4 1.7 1.7 8.6 1.0 2.3 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Gly-zipper_OmpA PF13436.1 CDI78341.1 - 0.057 13.0 16.9 0.03 13.9 8.4 3.3 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain DUF456 PF04306.8 CDI78341.1 - 0.38 10.7 9.5 0.018 15.0 2.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF456) Bacteriocin_IIc PF10439.4 CDI78341.1 - 0.57 10.3 17.2 2.6 8.2 12.0 2.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_Omp PF13488.1 CDI78341.1 - 0.76 9.4 26.4 2.9 7.6 18.3 2.0 1 0 0 1 1 1 0 Glycine zipper DUF4229 PF14012.1 CDI78341.1 - 3.8 7.4 6.0 19 5.2 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Neur_chan_memb PF02932.11 CDI78343.1 - 0.81 9.5 6.4 1.1 9.0 4.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Filo_glycop PF01611.11 CDI78343.1 - 1.7 7.3 7.5 2.4 6.8 5.2 1.2 1 0 0 1 1 1 0 Filovirus glycoprotein Autophagy_act_C PF03987.10 CDI78345.1 - 4.1e-28 97.3 0.2 6.4e-28 96.7 0.1 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_N PF03986.8 CDI78345.1 - 2.8e-14 53.1 0.0 4.6e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_Cterm PF10381.4 CDI78345.1 - 2.9e-12 45.4 2.4 4.9e-12 44.7 1.7 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal JAB PF01398.16 CDI78349.1 - 8.3e-22 77.0 0.2 3.5e-21 75.0 0.1 2.0 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 CDI78349.1 - 7.7e-06 25.4 0.1 3.1e-05 23.4 0.1 2.0 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain Ribosomal_S26e PF01283.14 CDI78350.1 - 2.2e-49 166.4 4.7 2.6e-49 166.2 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.2 CDI78350.1 - 0.052 13.9 1.8 0.14 12.5 1.1 1.9 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.1 CDI78350.1 - 0.16 11.8 2.3 4.3 7.2 1.6 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_10 PF13237.1 CDI78350.1 - 0.18 11.6 3.6 0.53 10.1 2.5 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain zf-ribbon_3 PF13248.1 CDI78350.1 - 1.6 8.0 5.9 3.8 6.8 4.1 1.8 1 1 0 1 1 1 0 zinc-ribbon domain Fer4_18 PF13746.1 CDI78350.1 - 3 8.3 7.1 3.5 8.1 1.4 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain PK PF00224.16 CDI78351.1 - 8e-145 481.8 0.7 1.1e-144 481.3 0.5 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 CDI78351.1 - 7.4e-33 112.5 0.9 3.9e-32 110.2 0.5 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 CDI78351.1 - 0.00032 19.6 0.2 0.0012 17.7 0.1 2.0 2 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Vps8 PF12816.2 CDI78351.1 - 0.13 11.5 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Dor1 PF04124.7 CDI78352.1 - 6.3e-11 41.3 0.6 1.7e-10 39.9 0.1 1.8 2 0 0 2 2 2 1 Dor1-like family Sec1 PF00995.18 CDI78353.1 - 2e-28 99.4 1.2 2.9e-20 72.4 0.1 3.0 2 1 0 2 2 2 2 Sec1 family DSPc PF00782.15 CDI78355.1 - 9.3e-25 86.7 0.0 1.4e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDI78355.1 - 0.00089 18.6 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 CDI78355.1 - 0.0014 18.7 0.7 0.0076 16.3 0.0 2.4 3 0 0 3 3 3 1 Inositol hexakisphosphate Proteasome PF00227.21 CDI78356.1 - 6e-59 198.5 0.0 7.4e-59 198.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDI78356.1 - 1.5e-14 52.9 0.4 2.5e-14 52.2 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GM_CSF PF01109.12 CDI78356.1 - 0.014 15.3 0.1 0.035 14.0 0.0 1.7 2 0 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor EF-hand_8 PF13833.1 CDI78357.1 - 9.2e-33 111.6 5.4 2.5e-17 62.1 0.4 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 CDI78357.1 - 4.8e-31 103.6 6.1 2e-09 36.0 0.5 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 CDI78357.1 - 2.7e-28 97.9 2.4 7.1e-19 67.7 0.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 CDI78357.1 - 1.1e-19 68.7 1.7 1e-05 24.6 0.0 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 CDI78357.1 - 1.3e-19 68.1 3.0 7.9e-08 31.5 0.0 4.3 4 1 0 4 4 4 3 EF-hand domain EF-hand_9 PF14658.1 CDI78357.1 - 4.4e-10 39.3 0.0 0.00042 20.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 CDI78357.1 - 8.3e-08 31.9 0.2 0.00022 20.9 0.0 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.8 CDI78357.1 - 1.5e-05 24.5 0.0 0.14 11.7 0.0 2.5 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.4 CDI78357.1 - 2.1e-05 24.4 0.0 0.0038 17.2 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.5 CDI78357.1 - 0.0011 18.8 0.1 0.0034 17.3 0.0 1.9 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF1103 PF06513.6 CDI78357.1 - 0.003 16.9 0.6 0.0039 16.6 0.4 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) RNA_pol_Rpb4 PF03874.11 CDI78357.1 - 0.0049 16.8 0.6 1.5 8.8 0.1 2.3 2 0 0 2 2 2 2 RNA polymerase Rpb4 TerB PF05099.8 CDI78357.1 - 0.026 14.2 0.3 5.4 6.7 0.0 2.1 1 1 1 2 2 2 0 Tellurite resistance protein TerB YqeY PF09424.5 CDI78357.1 - 0.029 14.2 0.2 0.078 12.8 0.1 1.7 1 1 0 1 1 1 0 Yqey-like protein DUF1880 PF08976.6 CDI78357.1 - 0.15 12.1 0.0 2.3 8.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1880) Ribosomal_S10 PF00338.17 CDI78358.1 - 7.9e-10 38.4 0.3 1.6e-07 31.0 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein S10p/S20e Ribosomal_L35Ae PF01247.13 CDI78359.1 - 1.4e-42 143.3 0.7 1.7e-42 143.1 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 CDI78359.1 - 0.066 13.1 0.1 7.8 6.4 0.0 2.3 2 0 0 2 2 2 0 RimM N-terminal domain OMPdecase PF00215.19 CDI78360.1 - 1.8e-11 43.8 0.0 1.2e-08 34.6 0.0 2.5 1 1 1 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family HEAT_EZ PF13513.1 CDI78360.1 - 1.3e-07 31.9 0.7 1.3e-07 31.9 0.5 8.7 8 1 0 8 8 8 2 HEAT-like repeat HEAT PF02985.17 CDI78360.1 - 2.1e-07 30.4 23.8 0.79 9.9 0.0 9.6 10 0 0 10 10 10 3 HEAT repeat IBN_N PF03810.14 CDI78360.1 - 7.7e-06 25.7 0.5 0.00016 21.4 0.2 3.3 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 CDI78360.1 - 0.0008 19.6 30.4 0.11 12.8 1.5 7.6 3 1 5 9 9 9 5 HEAT repeats PEARLI-4 PF05278.7 CDI78360.1 - 0.092 12.1 0.4 0.4 10.0 0.1 2.1 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) MMS19_C PF12460.3 CDI78360.1 - 0.17 10.5 0.0 2.8 6.5 0.0 2.8 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal UME PF08064.8 CDI78360.1 - 1.6 8.6 4.4 35 4.4 0.1 4.2 5 1 0 5 5 5 0 UME (NUC010) domain Cohesin_HEAT PF12765.2 CDI78360.1 - 2.7 8.0 8.0 48 4.0 0.1 4.0 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CwfJ_C_1 PF04677.10 CDI78361.1 - 2.5e-26 91.6 0.0 4.5e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 CDI78361.1 - 5.1e-10 39.7 0.0 5.1e-10 39.7 0.0 2.7 3 0 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 RRM_6 PF14259.1 CDI78361.1 - 8.2e-09 35.3 0.0 3.3e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI78361.1 - 3.2e-08 33.0 0.0 7.1e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI78361.1 - 1.3e-05 24.9 0.1 5.3e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DHHW PF14286.1 CDI78361.1 - 0.1 11.8 0.1 0.22 10.7 0.1 1.5 1 0 0 1 1 1 0 DHHW protein Ank_2 PF12796.2 CDI78362.1 - 1.4e-35 121.5 0.6 1.2e-11 44.7 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 CDI78362.1 - 2.3e-32 109.1 6.9 4.9e-05 22.9 0.0 6.5 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 CDI78362.1 - 1e-28 99.1 2.4 2e-07 31.3 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI78362.1 - 3.1e-18 64.0 1.0 0.064 13.5 0.0 6.6 5 1 1 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 CDI78362.1 - 2.2e-15 56.3 9.0 0.0083 16.3 0.2 6.2 3 2 3 6 6 6 6 Ankyrin repeats (many copies) RNA_GG_bind PF10258.4 CDI78362.1 - 1.8e-14 53.1 0.0 6.2e-14 51.4 0.0 1.9 1 0 0 1 1 1 1 PHAX RNA-binding domain B9-C2 PF07162.6 CDI78363.1 - 2e-12 47.2 0.0 2e-12 47.2 0.0 2.1 2 1 0 2 2 2 1 Ciliary basal body-associated, B9 protein Gti1_Pac2 PF09729.4 CDI78363.1 - 2.9 7.7 12.9 8.5 6.2 0.2 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Neur_chan_memb PF02932.11 CDI78363.1 - 8.3 6.2 11.5 17 5.1 8.0 1.5 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AP2 PF00847.15 CDI78364.1 - 1.1e-11 44.7 0.8 2.2e-07 30.9 0.0 6.2 8 0 0 8 8 8 2 AP2 domain ACDC PF14733.1 CDI78364.1 - 0.0012 18.9 0.0 0.0038 17.2 0.0 2.0 1 0 0 1 1 1 1 AP2-coincident C-terminal V_ATPase_I PF01496.14 CDI78364.1 - 7.9 4.2 6.7 26 2.4 0.0 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Robl_LC7 PF03259.12 CDI78365.1 - 0.26 10.8 1.7 0.4 10.2 0.0 2.1 1 1 1 2 2 2 0 Roadblock/LC7 domain DNA_processg_A PF02481.10 CDI78366.1 - 0.0019 17.1 1.2 0.0029 16.5 0.8 1.3 1 0 0 1 1 1 1 DNA recombination-mediator protein A tRNA-synt_His PF13393.1 CDI78367.1 - 8.8e-38 130.1 0.0 8.8e-38 130.1 0.0 4.5 3 1 2 5 5 5 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 CDI78367.1 - 5e-16 58.7 0.0 9.1e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.15 CDI78367.1 - 0.0067 15.6 0.0 0.022 13.9 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) PAT1 PF09770.4 CDI78367.1 - 0.33 9.1 60.8 0.0035 15.6 24.9 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Spore_coat_CotO PF14153.1 CDI78367.1 - 0.65 9.4 24.3 0.057 12.8 9.2 2.5 2 0 0 2 2 2 0 Spore coat protein CotO Ycf1 PF05758.7 CDI78367.1 - 1.3 6.6 12.8 0.11 10.2 5.0 1.7 2 0 0 2 2 2 0 Ycf1 UPF0564 PF10595.4 CDI78367.1 - 9.2 5.0 36.0 8.2 5.2 19.8 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 Adaptin_N PF01602.15 CDI78368.1 - 2.6e-15 55.7 0.0 3e-15 55.5 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 CDI78368.1 - 0.032 14.5 0.2 0.13 12.5 0.2 2.3 1 1 0 1 1 1 0 HEAT repeats Cse1 PF08506.5 CDI78369.1 - 3.1e-40 137.8 1.5 1.6e-18 66.4 0.0 4.4 2 1 0 3 3 3 3 Cse1 CAS_CSE1 PF03378.10 CDI78369.1 - 1.3e-31 109.4 3.3 1.3e-31 109.4 2.3 3.2 2 2 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 CDI78369.1 - 4.2e-09 36.1 1.2 4.2e-09 36.1 0.8 5.5 8 0 0 8 8 8 1 Importin-beta N-terminal domain PPR_3 PF13812.1 CDI78371.1 - 0.00065 19.7 2.7 1.3 9.4 0.1 4.9 4 0 0 4 4 4 1 Pentatricopeptide repeat domain TPR_16 PF13432.1 CDI78371.1 - 0.043 14.5 1.3 0.043 14.5 0.9 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat ACP_syn_III_C PF08541.5 CDI78371.1 - 0.15 12.1 3.1 13 5.9 0.0 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DUF3997 PF13162.1 CDI78371.1 - 0.17 11.6 1.6 0.68 9.7 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3997) TPR_14 PF13428.1 CDI78371.1 - 6.6 7.6 41.0 9.8 7.1 3.0 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat RE_AlwI PF09491.5 CDI78374.1 - 0.071 11.5 0.3 0.077 11.4 0.2 1.0 1 0 0 1 1 1 0 AlwI restriction endonuclease Nuf2 PF03800.9 CDI78376.1 - 0.087 12.7 0.5 0.14 12.1 0.1 1.5 1 1 0 1 1 1 0 Nuf2 family LEA_3 PF03242.8 CDI78376.1 - 0.42 10.8 3.2 0.5 10.6 2.2 1.2 1 0 0 1 1 1 0 Late embryogenesis abundant protein Spore_coat_CotO PF14153.1 CDI78376.1 - 3.3 7.0 8.5 3.6 6.9 5.9 1.0 1 0 0 1 1 1 0 Spore coat protein CotO DUF3987 PF13148.1 CDI78376.1 - 3.5 6.0 8.1 3.8 5.9 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF3138 PF11336.3 CDI78376.1 - 6.8 4.7 5.6 7.2 4.6 3.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Trypan_glycop PF00913.14 CDI78376.1 - 8.3 5.1 10.2 9.8 4.9 7.1 1.0 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) TPR_1 PF00515.23 CDI78377.1 - 0.03 13.9 12.5 5 6.9 0.6 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI78377.1 - 0.039 13.7 13.0 4.5 7.2 0.2 6.6 5 2 1 6 6 6 0 Tetratricopeptide repeat Pep3_Vps18 PF05131.9 CDI78377.1 - 0.085 12.2 1.2 14 5.0 0.1 2.9 2 0 0 2 2 2 0 Pep3/Vps18/deep orange family TPR_8 PF13181.1 CDI78377.1 - 1.4 8.8 7.7 11 6.1 0.2 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat CRPV_capsid PF08762.5 CDI78378.1 - 0.0013 18.2 0.4 0.0034 16.8 0.3 1.7 1 0 0 1 1 1 1 CRPV capsid protein like RNA_capsid PF03035.9 CDI78378.1 - 1.5 8.5 4.4 0.28 10.9 0.5 1.6 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein PTPS PF01242.14 CDI78379.1 - 4.2e-16 58.7 1.8 1.3e-14 53.9 1.3 2.4 1 1 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase SpoIIIAH PF12685.2 CDI78379.1 - 0.026 14.0 0.0 0.026 14.0 0.0 4.5 2 2 1 3 3 3 0 SpoIIIAH-like protein PAT1 PF09770.4 CDI78379.1 - 0.64 8.2 105.2 0.0047 15.2 29.9 3.1 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 zf-RING_2 PF13639.1 CDI78380.1 - 3e-11 42.9 11.7 6.9e-11 41.7 8.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDI78380.1 - 2.8e-10 40.1 5.2 6e-10 39.0 3.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CDI78380.1 - 2.2e-05 24.1 3.1 5.1e-05 23.0 2.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 CDI78380.1 - 0.00011 22.1 4.8 0.00026 20.8 3.3 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_3 PF14369.1 CDI78380.1 - 0.00046 20.1 0.3 0.00046 20.1 0.2 3.5 3 1 1 4 4 3 1 zinc-finger zf-C3HC4_2 PF13923.1 CDI78380.1 - 0.0031 17.5 10.8 0.0031 17.5 7.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI78380.1 - 0.0041 16.7 11.2 0.0041 16.7 7.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDI78380.1 - 0.0072 15.9 7.9 0.0072 15.9 5.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) 60KD_IMP PF02096.15 CDI78380.1 - 0.015 14.9 0.1 0.015 14.9 0.0 2.3 2 0 0 2 2 2 0 60Kd inner membrane protein Rad50_zn_hook PF04423.9 CDI78380.1 - 0.43 10.0 1.6 0.92 9.0 0.2 2.1 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_5 PF14634.1 CDI78380.1 - 1.9 8.3 16.7 0.33 10.7 6.8 2.5 2 0 0 2 2 2 0 zinc-RING finger domain TTL PF03133.10 CDI78381.1 - 1.3e-26 93.1 0.0 1.3e-26 93.1 0.0 5.2 6 1 1 7 7 7 2 Tubulin-tyrosine ligase family Myb_DNA-binding PF00249.26 CDI78382.1 - 8.3e-07 28.9 0.0 1.7e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Activator_LAG-3 PF11498.3 CDI78382.1 - 0.00084 18.2 5.1 0.00084 18.2 3.6 7.2 4 2 2 6 6 6 1 Transcriptional activator LAG-3 UBA PF00627.26 CDI78383.1 - 2.4e-08 33.5 0.5 6.8e-08 32.1 0.3 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Peptidase_C97 PF05903.9 CDI78383.1 - 9.4e-06 25.4 0.0 0.023 14.4 0.0 2.5 1 1 1 2 2 2 2 PPPDE putative peptidase domain PUB PF09409.5 CDI78383.1 - 1.3e-05 24.8 0.2 9.4e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 PUB domain SeqA PF03925.8 CDI78383.1 - 0.038 13.6 5.3 0.05 13.3 1.8 2.1 2 0 0 2 2 2 0 SeqA protein Aldedh PF00171.17 CDI78384.1 - 2.9e-112 375.3 1.3 2.1e-111 372.4 0.0 3.1 2 1 0 2 2 2 1 Aldehyde dehydrogenase family DNA_methylase PF00145.12 CDI78385.1 - 1.9e-21 76.5 12.5 8.5e-11 41.5 0.0 4.4 4 1 0 4 4 4 4 C-5 cytosine-specific DNA methylase Rpp20 PF12328.3 CDI78385.1 - 2.6 7.7 0.0 2.6 7.7 0.0 3.8 4 0 0 4 4 4 0 Rpp20 subunit of nuclear RNase MRP and P PHD PF00628.24 CDI78386.1 - 1e-11 44.3 4.2 1e-11 44.3 2.9 2.8 2 0 0 2 2 1 1 PHD-finger zf-RING_2 PF13639.1 CDI78386.1 - 3.8e-07 29.8 11.6 3.8e-07 29.8 8.1 2.6 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CDI78386.1 - 3.8e-05 23.7 5.1 3.8e-05 23.7 3.5 2.9 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 CDI78386.1 - 0.00018 21.1 8.4 0.00018 21.1 5.8 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI78386.1 - 0.00037 20.4 12.7 0.00037 20.4 8.8 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI78386.1 - 0.00046 19.7 11.7 0.00046 19.7 8.1 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Med15 PF09606.5 CDI78386.1 - 0.00059 18.1 27.6 0.00059 18.1 19.1 7.2 4 1 3 7 7 3 3 ARC105 or Med15 subunit of Mediator complex non-fungal PHD_2 PF13831.1 CDI78386.1 - 0.00082 18.6 1.3 0.0023 17.1 0.9 1.9 1 0 0 1 1 1 1 PHD-finger zf-RING_5 PF14634.1 CDI78386.1 - 0.0012 18.5 9.6 0.0012 18.5 6.7 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Baculo_IE-1 PF05290.6 CDI78386.1 - 0.0072 16.0 3.3 0.02 14.6 2.3 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_UBOX PF13445.1 CDI78386.1 - 0.059 13.0 6.5 0.32 10.7 4.5 2.4 1 0 0 1 1 1 0 RING-type zinc-finger DUF4407 PF14362.1 CDI78387.1 - 5.6 5.8 8.5 8.4 5.2 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_S8 PF00082.17 CDI78388.1 - 4.6e-14 52.2 12.7 4.6e-14 52.2 8.8 2.5 2 1 0 2 2 2 1 Subtilase family PolyA_pol PF01743.15 CDI78389.1 - 9.8e-09 35.5 0.5 3.8e-08 33.5 0.0 2.3 3 0 0 3 3 3 1 Poly A polymerase head domain Cpn60_TCP1 PF00118.19 CDI78392.1 - 1.3e-133 446.2 5.2 4.4e-133 444.4 3.6 1.7 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_60s PF00428.14 CDI78392.1 - 4 7.8 23.3 0.094 13.1 5.1 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein UNC-50 PF05216.8 CDI78393.1 - 1.3e-20 73.6 0.0 1.8e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 UNC-50 family Mannitol_dh_C PF08125.8 CDI78394.1 - 1.6e-57 194.4 0.3 2.8e-57 193.7 0.0 1.5 2 0 0 2 2 2 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.18 CDI78394.1 - 4.3e-23 81.9 0.0 3.9e-22 78.8 0.0 2.3 1 1 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain KH_1 PF00013.24 CDI78395.1 - 5.1e-36 122.1 0.0 6.2e-07 28.9 0.0 5.5 5 0 0 5 5 5 5 KH domain KH_3 PF13014.1 CDI78395.1 - 2e-28 97.5 2.9 2.9e-07 29.9 0.0 5.5 5 0 0 5 5 5 4 KH domain KH_2 PF07650.12 CDI78395.1 - 1.9e-08 33.7 0.3 0.47 10.0 0.0 4.3 4 0 0 4 4 4 3 KH domain KH_5 PF13184.1 CDI78395.1 - 5.8e-06 26.0 0.0 0.097 12.4 0.0 3.5 3 0 0 3 3 3 3 NusA-like KH domain Noc2 PF03715.8 CDI78396.1 - 2.1e-22 79.3 0.0 6e-22 77.8 0.0 1.8 1 0 0 1 1 1 1 Noc2p family CAF-1_p150 PF11600.3 CDI78397.1 - 0.0022 17.3 20.6 0.0022 17.3 14.3 10.9 12 1 0 12 12 12 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3819 PF12842.2 CDI78400.1 - 1.6e-51 173.8 7.2 7.4e-51 171.6 1.2 3.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3819) Not1 PF04054.10 CDI78400.1 - 1.3e-22 80.2 6.4 8.2e-20 71.0 0.3 3.2 3 0 0 3 3 3 2 CCR4-Not complex component, Not1 Arv1 PF04161.8 CDI78401.1 - 3.5e-27 95.6 6.3 1e-25 90.8 0.4 2.5 3 0 0 3 3 3 2 Arv1-like family Suf PF05843.9 CDI78401.1 - 0.23 11.1 14.8 1.3 8.6 0.1 3.1 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Nudix_N_2 PF14803.1 CDI78401.1 - 0.51 10.0 5.5 1.6 8.4 3.2 2.3 1 1 1 2 2 2 0 Nudix N-terminal Afi1 PF07792.7 CDI78401.1 - 0.57 10.1 5.5 1.4 8.9 0.8 2.9 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PCI_Csn8 PF10075.4 CDI78403.1 - 1e-12 48.0 0.0 1.9e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 CDI78403.1 - 7.4e-09 35.4 0.0 9.6e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family FimP PF09766.4 CDI78404.1 - 0.4 9.6 21.6 0.64 9.0 6.8 2.5 2 0 0 2 2 2 0 Fms-interacting protein YfhO PF09586.5 CDI78404.1 - 4.7 5.1 8.2 6.7 4.5 5.7 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Peptidase_S49_N PF08496.5 CDI78404.1 - 4.9 6.9 15.1 3.5 7.4 0.4 3.1 3 0 0 3 3 3 0 Peptidase family S49 N-terminal PTS_2-RNA PF01885.11 CDI78405.1 - 1.4e-46 158.1 0.1 4.1e-46 156.6 0.0 1.8 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Spt20 PF12090.3 CDI78405.1 - 2.9 7.1 36.8 0.18 11.1 6.0 3.9 4 0 0 4 4 4 0 Spt20 family AAA_23 PF13476.1 CDI78405.1 - 6.4 7.0 32.0 0.17 12.1 4.3 3.3 3 0 0 3 3 3 0 AAA domain Vps26 PF03643.10 CDI78408.1 - 1.3e-66 224.1 0.8 1.6e-66 223.9 0.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 CDI78408.1 - 0.034 13.9 0.2 2.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Ham1p_like PF01725.11 CDI78410.1 - 0.019 14.3 4.2 0.046 13.1 0.0 2.2 2 0 0 2 2 2 0 Ham1 family PapD-like PF14874.1 CDI78411.1 - 0.0058 16.5 0.2 7.8 6.5 0.0 3.8 4 0 0 4 4 4 2 Flagellar-associated PapD-like Motile_Sperm PF00635.21 CDI78411.1 - 0.05 13.2 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 MSP (Major sperm protein) domain WD40 PF00400.27 CDI78414.1 - 4.1e-24 83.5 18.0 7.9e-05 22.3 0.4 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat DUF2217 PF10265.4 CDI78414.1 - 0.27 9.9 9.2 0.38 9.4 6.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Binary_toxB PF03495.9 CDI78414.1 - 2.7 6.5 9.6 4 5.9 6.6 1.3 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA Macoilin PF09726.4 CDI78414.1 - 6.6 4.8 18.4 9.1 4.4 12.8 1.2 1 0 0 1 1 1 0 Transmembrane protein Apt1 PF10351.4 CDI78414.1 - 7.6 5.2 12.5 11 4.7 8.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hamartin PF04388.7 CDI78414.1 - 8.6 4.8 13.3 11 4.5 9.2 1.1 1 0 0 1 1 1 0 Hamartin protein TauE PF01925.14 CDI78415.1 - 1.2e-05 24.8 12.0 1.2e-05 24.8 8.3 3.8 2 1 2 4 4 4 1 Sulfite exporter TauE/SafE OmpH PF03938.9 CDI78417.1 - 0.00093 19.1 23.3 0.00098 19.0 16.2 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) zf-DHHC PF01529.15 CDI78417.1 - 0.1 11.9 0.7 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF2042 PF09743.4 CDI78418.1 - 1.1e-17 64.2 2.3 2e-17 63.4 0.0 2.4 2 1 1 3 3 3 2 Uncharacterized conserved protein (DUF2042) PAT1 PF09770.4 CDI78418.1 - 0.76 7.9 24.1 1 7.5 16.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dicty_REP PF05086.7 CDI78418.1 - 9.5 3.8 4.5 13 3.3 3.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Adeno_hexon PF01065.14 CDI78418.1 - 9.5 4.9 8.3 18 4.0 5.8 1.3 1 0 0 1 1 1 0 Hexon, adenovirus major coat protein, N-terminal domain FimP PF09766.4 CDI78419.1 - 0.0053 15.8 10.3 0.0053 15.8 7.1 2.9 2 1 0 2 2 2 1 Fms-interacting protein Pex24p PF06398.6 CDI78419.1 - 0.21 10.3 0.3 0.82 8.4 0.0 2.0 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin Ycf1 PF05758.7 CDI78419.1 - 2.1 5.9 15.0 0.025 12.3 0.2 2.1 2 0 0 2 2 2 0 Ycf1 Gti1_Pac2 PF09729.4 CDI78419.1 - 2.5 7.9 9.6 0.31 10.8 0.3 2.5 2 0 0 2 2 2 0 Gti1/Pac2 family LMBR1 PF04791.11 CDI78419.1 - 3.9 5.9 6.4 0.2 10.1 0.0 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein FAM60A PF15396.1 CDI78419.1 - 4.3 7.0 18.1 0.43 10.3 2.6 2.6 2 0 0 2 2 2 0 Protein Family FAM60A DUF89 PF01937.14 CDI78419.1 - 4.7 5.8 7.7 0.19 10.4 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF89 Serinc PF03348.10 CDI78419.1 - 7 5.2 15.0 0.048 12.3 0.9 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) Med15 PF09606.5 CDI78419.1 - 8.8 4.3 72.6 3.8 5.6 28.1 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Methyltransf_5 PF01795.14 CDI78420.1 - 1.3e-40 139.6 0.2 2.2e-21 76.4 0.7 3.7 3 1 0 3 3 3 3 MraW methylase family Herpes_U59 PF04529.7 CDI78420.1 - 0.032 13.0 0.2 0.049 12.4 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus U59 protein Methyltransf_31 PF13847.1 CDI78420.1 - 0.087 12.4 0.0 4.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 CDI78420.1 - 0.14 12.1 0.3 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase MTS PF05175.9 CDI78420.1 - 0.14 11.4 0.1 4.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase small domain Pro-rich PF15240.1 CDI78420.1 - 1.4 8.9 51.1 0.43 10.6 3.4 3.2 3 0 0 3 3 3 0 Proline-rich WD40 PF00400.27 CDI78421.1 - 5.2e-06 26.1 0.1 2.1e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF1767 PF08585.7 CDI78422.1 - 2.2e-07 31.0 0.4 1.1e-05 25.5 0.0 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF1767) IMS PF00817.15 CDI78423.1 - 1.6e-11 44.1 0.0 6.9e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 impB/mucB/samB family IMS_C PF11799.3 CDI78423.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 impB/mucB/samB family C-terminal domain CDK2AP PF09806.4 CDI78423.1 - 1.2 9.3 8.8 2.4 8.3 6.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Corona_nucleoca PF00937.13 CDI78425.1 - 0.00051 19.1 13.9 0.00051 19.1 9.6 1.8 2 0 0 2 2 2 1 Coronavirus nucleocapsid protein FoP_duplication PF13865.1 CDI78425.1 - 0.021 15.2 6.6 0.021 15.2 4.6 1.9 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 DUF2011 PF09428.5 CDI78425.1 - 0.39 10.6 11.4 0.038 13.8 4.1 1.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2011) Codanin-1_C PF15296.1 CDI78425.1 - 0.68 9.8 7.6 1.5 8.6 5.3 1.6 1 0 0 1 1 1 0 Codanin-1 C-terminus Peptidase_S64 PF08192.6 CDI78425.1 - 1.5 7.0 15.6 2 6.6 10.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 POX PF07526.6 CDI78425.1 - 2.2 8.5 16.9 0.71 10.1 6.8 2.2 2 0 0 2 2 2 0 Associated with HOX DUF2956 PF11169.3 CDI78425.1 - 3.3 7.7 14.6 1.3 8.9 6.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) TTL PF03133.10 CDI78426.1 - 9.8e-31 106.7 1.6 5.8e-17 61.5 0.9 8.9 9 1 1 10 10 10 3 Tubulin-tyrosine ligase family WD40 PF00400.27 CDI78427.1 - 4.7e-16 57.9 18.3 0.0021 17.8 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat NLE PF08154.7 CDI78427.1 - 1.1e-12 47.7 0.1 1.8e-12 47.0 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 CDI78427.1 - 4.7e-05 21.7 0.1 0.15 10.1 0.0 3.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF3446 PF11928.3 CDI78427.1 - 0.56 10.4 11.8 2.1 8.6 2.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) AWPM-19 PF05512.6 CDI78427.1 - 9.2 6.2 6.9 0.44 10.5 0.2 2.1 2 0 0 2 2 2 0 AWPM-19-like family Pkinase PF00069.20 CDI78431.1 - 2.4e-15 56.3 0.0 3.5e-12 46.0 0.0 3.7 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78431.1 - 0.0055 15.7 0.0 0.33 10.0 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase RAB3GAP2_N PF14655.1 CDI78431.1 - 1.4 7.8 6.9 0.5 9.3 0.5 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus zf-C2HC_2 PF13913.1 CDI78432.1 - 1.6e-10 40.3 10.7 1.7e-05 24.3 0.1 3.6 3 0 0 3 3 3 3 zinc-finger of a C2HC-type PyrI_C PF02748.10 CDI78432.1 - 0.0051 16.2 0.5 0.3 10.5 0.3 2.5 3 0 0 3 3 3 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain Sgf11 PF08209.6 CDI78432.1 - 0.076 12.3 10.3 0.082 12.2 0.7 3.3 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-ribbon_3 PF13248.1 CDI78432.1 - 0.25 10.6 5.5 1.7 7.9 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-TRAF PF02176.13 CDI78432.1 - 0.43 10.9 10.7 0.068 13.5 2.6 2.6 2 1 1 3 3 3 0 TRAF-type zinc finger Nudix_N_2 PF14803.1 CDI78432.1 - 0.49 10.1 5.1 23 4.7 0.0 3.6 3 0 0 3 3 3 0 Nudix N-terminal Cys_rich_CPCC PF14206.1 CDI78432.1 - 0.55 9.8 4.0 9.8 5.8 0.0 3.2 3 0 0 3 3 3 0 Cysteine-rich CPCC Zn-ribbon_8 PF09723.5 CDI78432.1 - 1.1 9.2 7.2 6.5 6.7 0.2 3.3 3 0 0 3 3 3 0 Zinc ribbon domain DUF3039 PF11238.3 CDI78432.1 - 1.2 8.6 4.1 5.1 6.6 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3039) RNHCP PF12647.2 CDI78432.1 - 2.3 8.1 5.6 0.81 9.5 1.3 2.2 2 1 1 3 3 2 0 RNHCP domain zf-MYND PF01753.13 CDI78432.1 - 2.5 8.0 7.7 1.7 8.5 1.6 2.7 2 1 0 2 2 2 0 MYND finger zinc_ribbon_2 PF13240.1 CDI78432.1 - 3.1 7.4 8.9 6.1 6.4 0.4 3.6 3 1 1 4 4 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 CDI78432.1 - 5.2 6.8 6.2 9.6 5.9 0.2 3.2 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.2 CDI78432.1 - 8 6.3 7.9 17 5.3 0.0 3.3 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Adaptin_N PF01602.15 CDI78433.1 - 5.9e-72 242.6 6.4 5e-67 226.4 2.3 2.0 2 0 0 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 CDI78433.1 - 1.2e-10 41.6 0.0 1.2e-10 41.6 0.0 2.4 2 0 0 2 2 2 1 Adaptin C-terminal domain HEAT_2 PF13646.1 CDI78433.1 - 0.0011 19.1 25.4 0.046 14.0 2.9 5.8 4 2 1 5 5 5 2 HEAT repeats Cnd1 PF12717.2 CDI78433.1 - 0.0019 18.0 0.6 0.011 15.5 0.3 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 MOR2-PAG1_N PF14222.1 CDI78433.1 - 0.097 11.3 4.9 1.8 7.1 0.1 2.6 2 0 0 2 2 2 0 Cell morphogenesis N-terminal DIM1 PF02966.11 CDI78434.1 - 3.5e-67 223.9 0.5 4e-67 223.8 0.3 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.15 CDI78434.1 - 0.0065 16.1 0.1 0.0084 15.7 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Orbi_VP3 PF01700.11 CDI78434.1 - 0.051 11.0 0.0 0.057 10.8 0.0 1.0 1 0 0 1 1 1 0 Orbivirus VP3 (T2) protein FAD_binding_7 PF03441.9 CDI78435.1 - 4.5e-32 111.3 0.7 4.5e-32 111.3 0.5 3.0 2 1 0 2 2 2 1 FAD binding domain of DNA photolyase SR-25 PF10500.4 CDI78435.1 - 6e-05 22.6 16.5 0.00012 21.6 11.5 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DNA_photolyase PF00875.13 CDI78435.1 - 0.00015 21.5 0.0 0.00015 21.5 0.0 2.6 2 1 0 2 2 2 1 DNA photolyase PV-1 PF06637.6 CDI78435.1 - 0.0026 16.4 10.0 0.0034 16.0 6.9 1.2 1 0 0 1 1 1 1 PV-1 protein (PLVAP) SOBP PF15279.1 CDI78435.1 - 0.042 14.2 10.8 0.062 13.6 7.5 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein LMBR1 PF04791.11 CDI78435.1 - 0.055 12.0 4.2 0.076 11.5 2.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Med15 PF09606.5 CDI78435.1 - 0.13 10.4 38.0 0.17 10.0 26.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3584 PF12128.3 CDI78435.1 - 0.27 8.5 27.2 0.38 8.0 18.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF342 PF03961.8 CDI78435.1 - 0.44 8.9 16.5 0.64 8.3 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) OmpH PF03938.9 CDI78435.1 - 0.46 10.4 45.1 0.98 9.3 31.3 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_23 PF13476.1 CDI78435.1 - 0.54 10.5 26.9 0.15 12.3 16.0 2.0 2 0 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.10 CDI78435.1 - 0.67 9.0 18.6 0.17 11.0 10.8 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit APG6 PF04111.7 CDI78435.1 - 0.79 8.7 25.6 0.2 10.6 14.7 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 SprA-related PF12118.3 CDI78435.1 - 0.94 8.7 27.4 1.5 8.0 19.0 1.2 1 0 0 1 1 1 0 SprA-related family DUF3552 PF12072.3 CDI78435.1 - 1.3 8.1 32.5 2.9 7.0 22.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) V_ATPase_I PF01496.14 CDI78435.1 - 2.7 5.7 12.8 4 5.1 8.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_GPO PF05929.6 CDI78435.1 - 8.2 5.5 15.1 16 4.6 10.4 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HSP70 PF00012.15 CDI78435.1 - 8.8 4.1 12.5 14 3.4 8.7 1.2 1 0 0 1 1 1 0 Hsp70 protein eIF-3c_N PF05470.7 CDI78436.1 - 9.5e-73 245.2 19.8 5.5e-71 239.4 13.7 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Daxx PF03344.10 CDI78436.1 - 0.0013 17.2 29.7 0.0013 17.2 20.6 1.5 2 0 0 2 2 2 1 Daxx Family Nop14 PF04147.7 CDI78436.1 - 0.52 8.1 38.4 0.014 13.4 21.8 1.8 2 0 0 2 2 2 0 Nop14-like family HXXEE PF13787.1 CDI78438.1 - 0.85 10.0 3.2 18 5.7 0.0 4.8 2 1 1 3 3 3 0 Protein of unknown function with HXXEE motif zf-U1 PF06220.7 CDI78439.1 - 1.4e-17 62.9 1.5 1.9e-17 62.4 1.0 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.3 CDI78439.1 - 0.00051 20.1 1.5 0.001 19.1 1.0 1.5 1 1 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.7 CDI78439.1 - 0.017 14.9 0.0 0.021 14.6 0.0 1.1 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Ribosomal_L35p PF01632.14 CDI78440.1 - 0.72 9.7 6.2 1.6 8.6 4.3 1.6 1 0 0 1 1 1 0 Ribosomal protein L35 Prefoldin_2 PF01920.15 CDI78441.1 - 2.6e-05 23.9 4.2 6.7e-05 22.5 2.9 1.6 1 1 0 1 1 1 1 Prefoldin subunit Methyltransf_16 PF10294.4 CDI78442.1 - 1.2e-17 63.9 0.2 7.9e-17 61.2 0.1 2.1 1 1 0 1 1 1 1 Putative methyltransferase Ank_2 PF12796.2 CDI78442.1 - 8.2e-15 54.9 7.6 5.8e-14 52.1 0.2 2.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI78442.1 - 1.2e-14 54.2 6.1 7.5e-10 39.0 1.1 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 CDI78442.1 - 3.7e-14 51.7 1.9 1.5e-08 34.0 0.2 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CDI78442.1 - 4.9e-11 42.5 8.3 2.8e-08 33.7 0.1 4.1 3 1 1 4 4 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI78442.1 - 6.6e-11 41.3 0.4 5.5e-06 26.1 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat Methyltransf_23 PF13489.1 CDI78442.1 - 4.3e-08 33.0 1.0 1.6e-07 31.2 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI78442.1 - 0.0013 19.2 0.2 0.011 16.2 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI78442.1 - 0.0022 18.4 0.2 0.02 15.3 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 CDI78442.1 - 0.0054 15.8 0.0 0.0054 15.8 0.0 2.4 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) RAB3GAP2_N PF14655.1 CDI78442.1 - 0.0059 15.6 8.7 0.24 10.3 0.1 2.4 2 0 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus MTS PF05175.9 CDI78442.1 - 0.023 14.0 0.0 0.023 14.0 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.7 CDI78442.1 - 0.04 14.3 0.4 0.24 11.8 0.0 2.5 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 CDI78442.1 - 0.078 12.5 0.4 0.61 9.6 0.3 2.4 1 1 0 1 1 1 0 Methyltransferase domain Mycoplasma_p37 PF06646.6 CDI78443.1 - 0.12 11.4 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 High affinity transport system protein p37 DUF3391 PF11871.3 CDI78443.1 - 0.54 10.4 5.5 0.84 9.8 3.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) PBP1_TM PF14812.1 CDI78443.1 - 0.69 10.2 3.5 1.6 9.1 2.4 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ycf1 PF05758.7 CDI78443.1 - 0.88 7.2 7.4 1 6.9 5.1 1.1 1 0 0 1 1 1 0 Ycf1 FAM176 PF14851.1 CDI78443.1 - 1.4 8.5 12.7 1.6 8.4 8.1 1.6 1 1 0 1 1 1 0 FAM176 family Myc_N PF01056.13 CDI78443.1 - 3.2 6.8 12.8 3.2 6.8 8.5 1.4 1 1 0 1 1 1 0 Myc amino-terminal region Tom37_C PF11801.3 CDI78443.1 - 6.4 6.6 8.6 5.9 6.7 5.2 1.4 1 1 0 1 1 1 0 Tom37 C-terminal domain Cellulose_synt PF03552.9 CDI78444.1 - 0.19 9.9 2.7 0.46 8.7 1.9 1.6 1 0 0 1 1 1 0 Cellulose synthase Ycf1 PF05758.7 CDI78444.1 - 1.7 6.2 22.1 0.29 8.7 8.3 2.2 2 0 0 2 2 2 0 Ycf1 LMBR1 PF04791.11 CDI78444.1 - 3.7 6.0 3.0 10 4.5 2.1 1.7 1 0 0 1 1 1 0 LMBR1-like membrane protein Mito_carr PF00153.22 CDI78445.1 - 9.1e-10 38.1 2.7 6.7e-08 32.1 1.7 4.7 4 2 1 5 5 5 2 Mitochondrial carrier protein DUF342 PF03961.8 CDI78445.1 - 0.0016 16.9 6.0 0.0021 16.5 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Phage_GPO PF05929.6 CDI78445.1 - 0.36 10.0 18.2 0.047 12.9 9.9 1.4 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase FAM60A PF15396.1 CDI78445.1 - 0.68 9.6 16.0 0.046 13.4 7.2 1.8 2 0 0 2 2 2 0 Protein Family FAM60A DUF3810 PF12725.2 CDI78445.1 - 1.4 7.7 7.0 2.3 7.0 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DDE_Tnp_ISL3 PF01610.12 CDI78445.1 - 7.8 5.9 8.9 14 5.1 6.2 1.3 1 0 0 1 1 1 0 Transposase Metallophos PF00149.23 CDI78446.1 - 2e-19 69.8 0.0 3.8e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mre11_DNA_bind PF04152.9 CDI78446.1 - 1.6e-11 44.3 0.5 1.5e-06 28.1 0.0 3.5 3 0 0 3 3 3 2 Mre11 DNA-binding presumed domain Metallophos_2 PF12850.2 CDI78446.1 - 0.00048 19.9 0.2 0.0047 16.7 0.1 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2205 PF10224.4 CDI78447.1 - 0.024 14.2 0.7 0.059 12.9 0.5 1.6 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) SlyX PF04102.7 CDI78447.1 - 0.081 13.3 0.9 0.56 10.6 0.0 2.6 2 0 0 2 2 2 0 SlyX VPS11_C PF12451.3 CDI78447.1 - 0.18 11.6 1.1 23 4.9 0.1 2.7 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal WD40 PF00400.27 CDI78449.1 - 0.0006 19.5 3.8 22 5.1 0.0 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat DER1 PF04511.10 CDI78451.1 - 7.4e-42 143.0 14.5 8.3e-42 142.9 10.0 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 CDI78451.1 - 5.5e-06 26.4 16.1 8.7e-06 25.8 11.1 1.3 1 0 0 1 1 1 1 Rhomboid family Caldesmon PF02029.10 CDI78453.1 - 0.0063 14.9 0.0 0.0063 14.9 0.0 1.4 2 0 0 2 2 2 1 Caldesmon RNA_polI_A34 PF08208.6 CDI78454.1 - 0.071 12.7 14.3 0.072 12.7 9.9 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TRAP_alpha PF03896.11 CDI78454.1 - 0.75 8.7 19.6 0.8 8.6 13.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Daxx PF03344.10 CDI78454.1 - 0.98 7.8 30.4 0.95 7.8 21.1 1.0 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 CDI78454.1 - 0.98 7.3 17.2 0.96 7.3 11.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.8 CDI78454.1 - 1.1 8.7 22.7 1.3 8.6 15.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region WBS_methylT PF12589.3 CDI78454.1 - 1.8 9.0 7.7 2.3 8.7 5.3 1.3 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome AIF_C PF14721.1 CDI78454.1 - 1.9 8.7 6.4 1.9 8.7 4.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RNA_pol_3_Rpc31 PF11705.3 CDI78454.1 - 2.7 7.8 24.1 3 7.7 16.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CobT PF06213.7 CDI78454.1 - 3.2 6.8 25.9 3.1 6.8 18.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1510 PF07423.6 CDI78454.1 - 3.2 7.0 23.8 3.5 6.9 16.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Usp PF00582.21 CDI78454.1 - 3.6 7.7 10.4 4 7.6 7.2 1.2 1 0 0 1 1 1 0 Universal stress protein family DUF2722 PF10846.3 CDI78454.1 - 4.7 6.1 7.8 4.4 6.2 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Nop14 PF04147.7 CDI78454.1 - 5.1 4.8 30.5 5.4 4.8 21.1 1.0 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.17 CDI78454.1 - 5.7 5.8 7.1 5.5 5.9 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Tom37_C PF11801.3 CDI78454.1 - 6 6.7 8.0 6.2 6.6 5.5 1.1 1 0 0 1 1 1 0 Tom37 C-terminal domain DDHD PF02862.12 CDI78454.1 - 6.4 6.5 11.4 6.3 6.5 7.9 1.0 1 0 0 1 1 1 0 DDHD domain YqfQ PF14181.1 CDI78454.1 - 6.4 6.7 15.9 7 6.6 11.0 1.1 1 0 0 1 1 1 0 YqfQ-like protein NPR3 PF03666.8 CDI78454.1 - 6.6 5.1 7.1 6.1 5.2 4.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ycf1 PF05758.7 CDI78454.1 - 6.7 4.2 13.3 6.4 4.3 9.2 1.0 1 0 0 1 1 1 0 Ycf1 Tim54 PF11711.3 CDI78454.1 - 7.1 5.1 14.2 6.6 5.2 9.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ATP-synt_E PF05680.7 CDI78454.1 - 8.8 6.3 11.1 11 6.0 7.7 1.3 1 0 0 1 1 1 0 ATP synthase E chain Serinc PF03348.10 CDI78454.1 - 8.8 4.9 6.2 8.5 4.9 4.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_pol_Rpc4 PF05132.9 CDI78454.1 - 9.2 6.2 12.9 10 6.1 9.0 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPW_WPC PF09717.5 CDI78455.1 - 4.9e-08 33.4 0.0 3.7e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 Plasmodium falciparum domain of unknown function (CPW_WPC) cEGF PF12662.2 CDI78455.1 - 0.022 14.3 0.2 0.022 14.3 0.2 1.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like Glyoxalase PF00903.20 CDI78456.1 - 1.8e-37 128.1 0.2 9.3e-18 64.4 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CDI78456.1 - 7e-30 103.8 0.0 4.5e-15 56.1 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 CDI78456.1 - 1.4e-15 57.2 0.1 6.9e-07 29.2 0.0 3.1 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 CDI78456.1 - 0.00037 20.4 0.0 0.78 9.6 0.0 2.7 1 1 1 2 2 2 2 Glyoxalase-like domain DUF3081 PF11280.3 CDI78456.1 - 0.0032 16.9 0.1 2.9 7.4 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF3081) CppA_N PF14506.1 CDI78456.1 - 0.0077 15.9 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 2 CppA N-terminal MMR_HSR1_C PF08438.5 CDI78458.1 - 3e-09 37.0 0.4 8.9e-09 35.5 0.0 2.0 2 1 0 2 2 2 1 GTPase of unknown function C-terminal TGS PF02824.16 CDI78458.1 - 6.5e-05 22.6 0.0 0.00044 20.0 0.0 2.2 2 0 0 2 2 2 1 TGS domain RNA_pol_Rpc82 PF05645.8 CDI78459.1 - 0.004 16.7 0.4 1.8 8.0 0.0 2.6 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 CDI78459.1 - 0.085 12.7 1.2 9.6 6.1 0.0 2.8 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain TSA PF03249.8 CDI78459.1 - 8.6 4.7 17.8 0.13 10.7 4.9 2.4 2 0 0 2 2 2 0 Type specific antigen RRM_1 PF00076.17 CDI78460.1 - 1.7e-39 133.2 0.0 3.4e-21 74.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI78460.1 - 4.2e-28 97.1 0.0 1.2e-13 50.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI78460.1 - 6.1e-19 67.6 0.0 2.2e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 CDI78460.1 - 0.013 15.0 0.1 4.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Limkain-b1 PF11608.3 CDI78460.1 - 0.016 14.9 0.0 0.22 11.3 0.0 2.1 1 1 1 2 2 2 0 Limkain b1 Amino_oxidase PF01593.19 CDI78461.1 - 2.4e-28 99.4 18.9 9.6e-11 41.4 0.0 5.0 4 0 0 4 4 4 4 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CDI78461.1 - 3.4e-07 30.2 6.2 2.7e-06 27.2 4.3 2.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CDI78461.1 - 0.00034 20.9 3.1 0.00082 19.7 2.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CDI78461.1 - 0.00059 19.7 0.7 0.00059 19.7 0.5 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI78461.1 - 0.082 11.9 1.2 0.16 11.0 0.8 1.4 1 0 0 1 1 1 0 Thi4 family HisKA_3 PF07730.8 CDI78462.1 - 0.017 15.4 0.2 0.14 12.5 0.1 2.4 2 0 0 2 2 2 0 Histidine kinase Gp_dh_C PF02800.15 CDI78463.1 - 4.5e-70 234.1 0.0 5.8e-70 233.7 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 CDI78463.1 - 5.6e-63 211.4 0.0 9.3e-63 210.7 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 CDI78463.1 - 0.025 14.5 0.1 0.07 13.0 0.0 1.9 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus LAT PF15234.1 CDI78465.1 - 0.061 12.7 6.8 0.083 12.3 4.7 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells DDHD PF02862.12 CDI78466.1 - 5.7e-21 75.3 15.0 2e-17 63.7 0.0 4.8 3 2 0 3 3 3 2 DDHD domain Spt20 PF12090.3 CDI78466.1 - 2.6 7.3 8.7 3.6 6.9 1.0 2.4 2 0 0 2 2 2 0 Spt20 family Mpp10 PF04006.7 CDI78468.1 - 2.5e-30 105.4 125.0 3.6e-23 81.7 6.6 4.4 2 1 1 3 3 3 2 Mpp10 protein stn_TNFRSF12A PF12191.3 CDI78469.1 - 0.015 15.3 0.2 0.022 14.8 0.2 1.2 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF2360 PF10152.4 CDI78469.1 - 0.14 12.4 5.0 0.24 11.6 3.4 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TRAP_alpha PF03896.11 CDI78469.1 - 0.16 10.9 0.3 0.22 10.4 0.2 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1180 PF06679.7 CDI78469.1 - 0.85 9.4 4.1 1.7 8.5 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) WD40 PF00400.27 CDI78470.1 - 0.0016 18.2 6.4 0.011 15.5 1.0 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat SdiA-regulated PF06977.6 CDI78471.1 - 0.25 10.2 2.4 0.28 10.1 1.7 1.1 1 0 0 1 1 1 0 SdiA-regulated DUF775 PF05603.7 CDI78471.1 - 1.5 8.2 8.7 2.2 7.7 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FUSC PF04632.7 CDI78471.1 - 5.4 5.3 11.8 5.6 5.2 8.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF687 PF05095.7 CDI78471.1 - 6.9 4.9 7.1 7 4.8 4.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF687) Spt20 PF12090.3 CDI78472.1 - 0.063 12.6 2.9 0.054 12.8 2.0 1.1 1 0 0 1 1 1 0 Spt20 family eIF_4EBP PF05456.6 CDI78472.1 - 0.17 11.5 3.0 0.31 10.7 2.1 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Suf PF05843.9 CDI78472.1 - 0.89 9.2 9.0 0.9 9.2 6.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med15 PF09606.5 CDI78472.1 - 2.3 6.3 29.5 2.6 6.1 20.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CDC45 PF02724.9 CDI78472.1 - 7.3 4.4 10.9 9.2 4.1 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4557 PF15101.1 CDI78472.1 - 8.1 6.2 12.9 9.8 5.9 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Ribosomal_S9 PF00380.14 CDI78473.1 - 2.3e-22 79.4 0.2 2.7e-22 79.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13e PF01294.13 CDI78474.1 - 7.9e-63 211.1 9.8 9.6e-63 210.8 6.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e DSPc PF00782.15 CDI78476.1 - 7.6e-18 64.3 0.1 1.6e-17 63.3 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain YajC PF02699.10 CDI78477.1 - 0.29 10.8 0.2 0.69 9.6 0.1 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit RskA PF10099.4 CDI78478.1 - 0.00015 21.5 32.3 0.2 11.4 4.6 5.5 5 0 0 5 5 5 5 Anti-sigma-K factor rskA GP40 PF11025.3 CDI78478.1 - 0.094 12.2 2.7 0.23 11.0 1.9 1.6 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium BTB PF00651.26 CDI78479.1 - 3.1e-08 33.5 0.2 7.3e-08 32.3 0.1 1.6 1 1 0 1 1 1 1 BTB/POZ domain ESX-1_EspG PF14011.1 CDI78479.1 - 0.0063 15.8 0.1 0.0067 15.6 0.1 1.1 1 0 0 1 1 1 1 EspG family Exonuc_X-T_C PF08411.5 CDI78479.1 - 0.044 12.8 0.1 0.049 12.6 0.0 1.1 1 0 0 1 1 1 0 Exonuclease C-terminal Dus PF01207.12 CDI78480.1 - 9.6e-23 80.4 0.0 8e-19 67.5 0.0 3.3 3 1 0 3 3 3 2 Dihydrouridine synthase (Dus) DUF2102 PF09875.4 CDI78480.1 - 0.13 11.7 0.3 0.36 10.3 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2102) Met_10 PF02475.11 CDI78482.1 - 5.6e-27 94.6 0.0 3.7e-26 91.9 0.0 2.0 1 1 0 1 1 1 1 Met-10+ like-protein DUF1971 PF09313.6 CDI78482.1 - 2.8 7.7 7.8 15 5.3 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1971) DUF2526 PF10735.4 CDI78482.1 - 2.9 7.9 8.5 10 6.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2526) DUF1180 PF06679.7 CDI78483.1 - 0.026 14.4 0.1 0.065 13.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3040 PF11239.3 CDI78483.1 - 0.1 12.6 2.2 0.37 10.8 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Snapin_Pallidin PF14712.1 CDI78483.1 - 0.52 10.6 5.3 1.2 9.5 0.1 2.7 3 0 0 3 3 3 0 Snapin/Pallidin IBN_N PF03810.14 CDI78487.1 - 2.1e-10 40.3 0.0 3e-09 36.6 0.0 3.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.5 CDI78487.1 - 6.4e-07 28.2 0.0 4.3e-06 25.5 0.0 2.3 2 0 0 2 2 2 1 Cse1 Xpo1 PF08389.7 CDI78487.1 - 0.13 12.1 9.6 0.024 14.5 1.4 3.3 3 1 0 3 3 3 0 Exportin 1-like protein PABP PF00658.13 CDI78487.1 - 2 8.1 9.4 0.33 10.6 0.1 3.3 3 0 0 3 3 3 0 Poly-adenylate binding protein, unique domain LSM PF01423.17 CDI78488.1 - 9.1e-20 69.9 0.0 1.1e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CDI78488.1 - 0.0014 18.4 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain RIO1 PF01163.17 CDI78490.1 - 2.2e-50 170.6 0.5 2.6e-24 85.6 0.0 2.9 2 1 0 2 2 2 2 RIO1 family APH PF01636.18 CDI78490.1 - 0.0053 16.5 0.2 3.9 7.1 0.0 2.8 2 1 0 2 2 2 2 Phosphotransferase enzyme family SURF6 PF04935.7 CDI78491.1 - 0.00027 20.2 58.5 0.00027 20.2 40.6 3.1 1 1 2 3 3 3 1 Surfeit locus protein 6 TerD PF02342.13 CDI78492.1 - 3.5e-16 59.0 0.0 4.8e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 TerD domain Dispanin PF04505.7 CDI78493.1 - 0.52 9.8 2.9 1.1 8.8 2.0 1.6 1 1 0 1 1 1 0 Interferon-induced transmembrane protein DEAD PF00270.24 CDI78494.1 - 1.1e-32 112.8 0.0 1.7e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI78494.1 - 1.6e-25 88.7 0.0 8.2e-25 86.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Proteasome PF00227.21 CDI78495.1 - 3.8e-58 195.9 0.0 5.4e-58 195.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDI78495.1 - 7.6e-11 41.1 0.9 1.9e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RecA PF00154.16 CDI78495.1 - 0.074 12.1 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein OmpH PF03938.9 CDI78498.1 - 0.0021 18.0 8.2 0.0021 18.0 5.7 22.6 14 8 2 16 16 16 2 Outer membrane protein (OmpH-like) DUF1453 PF07301.6 CDI78498.1 - 0.17 11.7 0.0 6.2 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1453) Amino_oxidase PF01593.19 CDI78499.1 - 2.6e-38 132.2 12.5 3.3e-21 75.8 0.3 4.2 3 1 1 4 4 4 3 Flavin containing amine oxidoreductase zf-CW PF07496.10 CDI78499.1 - 2e-33 113.8 37.6 2.5e-11 43.0 5.9 3.6 3 0 0 3 3 3 3 CW-type Zinc Finger NAD_binding_8 PF13450.1 CDI78499.1 - 1.1e-06 28.4 0.8 1.1e-06 28.4 0.6 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 CDI78499.1 - 0.00023 21.1 0.1 0.00095 19.1 0.1 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI78499.1 - 0.0057 17.0 0.1 0.017 15.5 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI78499.1 - 0.0062 15.6 0.3 0.022 13.8 0.2 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.1 CDI78499.1 - 0.071 13.1 0.1 0.071 13.1 0.1 3.2 3 1 1 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase PHD PF00628.24 CDI78499.1 - 9.7 5.9 16.1 10 5.9 0.3 4.5 4 1 0 4 4 4 0 PHD-finger Dynamin_M PF01031.15 CDI78500.1 - 6.9e-77 258.1 0.0 8.5e-76 254.5 0.0 2.1 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 CDI78500.1 - 1.9e-31 109.1 0.0 4.9e-31 107.7 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 CDI78500.1 - 8.6e-31 105.6 1.8 8.6e-31 105.6 1.2 2.2 3 0 0 3 3 3 1 Dynamin GTPase effector domain TRAM_LAG1_CLN8 PF03798.11 CDI78502.1 - 4.5e-21 75.3 15.3 5.9e-21 74.9 10.6 1.1 1 0 0 1 1 1 1 TLC domain DUF4234 PF14018.1 CDI78502.1 - 1.3 8.8 9.6 6 6.6 6.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) Pkinase PF00069.20 CDI78504.1 - 1.9e-41 141.9 0.0 2.6e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78504.1 - 2.1e-23 82.7 0.0 2.9e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI78504.1 - 3.8e-05 23.5 0.1 0.011 15.4 0.0 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 CDI78504.1 - 0.026 13.3 0.1 0.04 12.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.11 CDI78504.1 - 0.062 13.2 0.0 0.19 11.7 0.0 1.7 1 1 0 1 1 1 0 ABC1 family Kinase-like PF14531.1 CDI78504.1 - 0.081 11.8 0.0 2.4 7.0 0.0 2.6 3 0 0 3 3 3 0 Kinase-like Nucleoporin_FG PF13634.1 CDI78505.1 - 5.1e-13 49.2 175.6 7.2e-05 22.9 36.3 6.2 1 1 3 4 4 4 2 Nucleoporin FG repeat region Nsp1_C PF05064.8 CDI78505.1 - 2e-12 46.8 5.3 2e-12 46.8 3.7 2.1 2 1 0 2 2 2 1 Nsp1-like C-terminal region DUF1664 PF07889.7 CDI78505.1 - 0.055 13.2 5.9 1.3 8.8 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Nup88 PF10168.4 CDI78505.1 - 0.13 10.0 7.7 0.18 9.6 5.3 1.0 1 0 0 1 1 1 0 Nuclear pore component Occludin_ELL PF07303.8 CDI78505.1 - 0.54 11.0 2.8 3.5 8.4 0.2 2.4 1 1 1 2 2 2 0 Occludin homology domain Baculo_PEP_C PF04513.7 CDI78505.1 - 1.1 9.1 9.4 0.5 10.1 3.6 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.1 CDI78505.1 - 2.1 6.7 6.2 2.5 6.4 4.3 1.0 1 0 0 1 1 1 0 AAA domain Aconitase PF00330.15 CDI78506.1 - 4.2e-117 391.4 0.0 3.6e-107 358.7 0.0 2.2 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CDI78506.1 - 1.1e-22 80.5 0.0 2.2e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain H_lectin PF09458.5 CDI78507.1 - 0.031 13.9 0.0 0.33 10.6 0.0 2.8 3 0 0 3 3 3 0 H-type lectin domain TSP_1 PF00090.14 CDI78509.1 - 4.3e-09 36.3 14.4 0.0014 18.7 0.8 5.0 3 0 0 3 3 3 3 Thrombospondin type 1 domain Ninjurin PF04923.7 CDI78509.1 - 0.092 12.4 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Ninjurin G-patch_2 PF12656.2 CDI78510.1 - 3.1e-05 23.7 0.0 3.1e-05 23.7 0.0 2.9 2 0 0 2 2 2 1 DExH-box splicing factor binding site RAB3GAP2_N PF14655.1 CDI78510.1 - 0.0073 15.3 0.5 0.0073 15.3 0.3 2.2 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Trypan_PARP PF05887.6 CDI78511.1 - 0.00048 19.9 0.6 0.00076 19.3 0.4 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) RNase_PH PF01138.16 CDI78511.1 - 0.0077 16.5 5.7 0.096 13.0 3.9 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Orthopox_A5L PF06193.6 CDI78511.1 - 0.019 14.8 4.1 0.035 14.0 2.8 1.4 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like NESP55 PF06390.7 CDI78511.1 - 0.11 11.8 11.1 0.15 11.4 7.7 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Daxx PF03344.10 CDI78511.1 - 1.7 7.0 14.1 2.1 6.7 9.8 1.0 1 0 0 1 1 1 0 Daxx Family DUF3633 PF12315.3 CDI78511.1 - 3.7 6.8 9.4 0.53 9.5 2.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3633) API5 PF05918.6 CDI78513.1 - 0.25 9.8 6.3 0.39 9.1 4.3 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) OSCP PF00213.13 CDI78514.1 - 0.0099 15.7 0.6 0.04 13.7 0.3 2.0 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit DnaJ PF00226.26 CDI78515.1 - 1.1e-14 53.8 0.4 2.4e-14 52.7 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.15 CDI78515.1 - 0.018 14.7 0.0 0.034 13.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin FlxA PF14282.1 CDI78516.1 - 0.023 14.6 27.2 0.023 14.6 18.9 3.1 3 0 0 3 3 3 0 FlxA-like protein BTV_NS2 PF04514.7 CDI78516.1 - 0.029 13.2 5.9 0.041 12.7 4.1 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 tRNA-synt_1f PF01921.13 CDI78516.1 - 0.033 12.8 0.0 0.033 12.8 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (K) EMP24_GP25L PF01105.19 CDI78516.1 - 0.072 12.7 3.8 0.53 9.9 0.4 2.3 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF3573 PF12097.3 CDI78516.1 - 0.14 10.7 1.9 0.2 10.2 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) PAT1 PF09770.4 CDI78516.1 - 0.68 8.0 26.6 0.8 7.8 18.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3533 PF12051.3 CDI78516.1 - 0.81 8.3 3.1 1.1 7.8 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF2681 PF10883.3 CDI78516.1 - 1.5 9.0 12.4 3.3 7.9 6.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) vMSA PF00695.14 CDI78516.1 - 1.8 7.6 4.5 2.3 7.3 3.1 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus DUF947 PF06102.7 CDI78516.1 - 1.9 8.2 9.4 0.42 10.4 4.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF947) GAGA_bind PF06217.7 CDI78516.1 - 2.4 8.0 8.5 2.8 7.8 5.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family NYN_YacP PF05991.6 CDI78516.1 - 4.5 6.9 13.8 15 5.2 4.3 3.1 2 1 1 3 3 3 0 YacP-like NYN domain Ycf1 PF05758.7 CDI78516.1 - 5.1 4.6 6.3 5.6 4.5 4.4 1.1 1 0 0 1 1 1 0 Ycf1 Bestrophin PF01062.16 CDI78516.1 - 7.6 5.3 7.4 0.98 8.2 0.2 2.0 1 1 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel DUF4319 PF14203.1 CDI78518.1 - 0.0087 15.5 0.3 1.9 8.0 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4319) Ras PF00071.17 CDI78519.1 - 5.5e-08 32.3 0.0 7.6e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Ribosomal_60s PF00428.14 CDI78519.1 - 0.00065 20.0 11.7 0.00065 20.0 8.1 2.4 2 1 0 2 2 2 1 60s Acidic ribosomal protein Miro PF08477.8 CDI78519.1 - 0.0075 16.7 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 CDI78519.1 - 0.11 12.4 0.9 0.55 10.1 0.7 1.8 1 1 0 1 1 1 0 AAA ATPase domain Nop14 PF04147.7 CDI78519.1 - 0.29 8.9 5.2 0.35 8.7 3.6 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 CDI78519.1 - 0.36 9.8 4.1 0.42 9.6 2.8 1.1 1 0 0 1 1 1 0 BUD22 Daxx PF03344.10 CDI78519.1 - 0.97 7.8 4.1 1.2 7.5 2.8 1.0 1 0 0 1 1 1 0 Daxx Family CS PF04969.11 CDI78522.1 - 6e-09 36.3 0.1 8.6e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 CS domain COX4 PF02936.9 CDI78522.1 - 0.0044 16.7 1.6 0.0075 16.0 1.1 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV YEATS PF03366.11 CDI78523.1 - 0.015 15.0 17.2 3.5 7.4 0.0 8.0 7 2 2 9 9 9 0 YEATS family Potassium_chann PF11404.3 CDI78523.1 - 1.4 8.7 9.0 1.6 8.5 0.2 4.8 5 0 0 5 5 5 0 Potassium voltage-gated channel DUF1168 PF06658.7 CDI78524.1 - 3.1e-25 88.3 23.2 3.1e-25 88.3 16.1 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF1168) DUF674 PF05056.7 CDI78524.1 - 0.11 11.1 0.1 0.11 11.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF674) IncA PF04156.9 CDI78524.1 - 4.9 6.6 20.6 10 5.6 14.3 1.5 1 0 0 1 1 1 0 IncA protein HEAT PF02985.17 CDI78525.1 - 0.0002 21.1 9.7 0.095 12.8 0.1 4.6 3 0 0 3 3 3 2 HEAT repeat SpoIIE PF07228.7 CDI78526.1 - 0.00057 19.6 1.5 0.0025 17.5 0.1 3.0 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 CDI78526.1 - 0.0012 18.2 0.0 0.012 15.0 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C CTP_transf_1 PF01148.15 CDI78527.1 - 1.3e-22 80.6 10.9 2.1e-21 76.7 4.7 3.4 2 1 0 2 2 2 1 Cytidylyltransferase family Apt1 PF10351.4 CDI78527.1 - 0.12 11.1 14.5 0.32 9.8 0.4 3.0 3 0 0 3 3 3 0 Golgi-body localisation protein domain DUF4512 PF14975.1 CDI78527.1 - 0.14 12.9 0.2 0.14 12.9 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4512) EIIBC-GUT_N PF03612.9 CDI78527.1 - 1.4 8.4 9.5 3.9 7.0 0.3 3.3 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus DDHD PF02862.12 CDI78527.1 - 4.7 6.9 18.7 17 5.1 0.0 3.3 3 0 0 3 3 3 0 DDHD domain YjgP_YjgQ PF03739.9 CDI78527.1 - 5.1 5.7 5.7 3.2 6.4 0.4 2.2 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family Kei1 PF08552.6 CDI78527.1 - 6.9 6.2 16.1 1.3 8.6 0.2 3.2 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_S15 PF02129.13 CDI78527.1 - 9.2 5.5 14.4 0.17 11.3 0.6 2.6 3 0 0 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Helicase_C PF00271.26 CDI78528.1 - 1.5e-17 63.2 0.0 1.5e-17 63.2 0.0 2.4 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Spore_coat_CotO PF14153.1 CDI78528.1 - 0.0053 16.2 8.2 0.0053 16.2 5.7 2.3 2 0 0 2 2 2 1 Spore coat protein CotO Response_reg PF00072.19 CDI78528.1 - 0.28 11.2 1.5 0.44 10.5 0.0 2.1 2 0 0 2 2 2 0 Response regulator receiver domain Pex14_N PF04695.8 CDI78528.1 - 2.3 8.2 22.1 0.34 10.9 6.1 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Activator_LAG-3 PF11498.3 CDI78528.1 - 4.7 5.8 49.1 0.25 10.0 17.7 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 OmpH PF03938.9 CDI78528.1 - 8.8 6.2 35.6 0.061 13.2 9.7 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HRDC PF00570.18 CDI78529.1 - 3.2e-05 23.5 0.0 4.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 HRDC domain SOBP PF15279.1 CDI78530.1 - 6.1e-05 23.5 15.1 0.013 15.8 5.9 2.6 2 0 0 2 2 2 2 Sine oculis-binding protein Serglycin PF04360.7 CDI78530.1 - 0.0024 17.6 0.6 0.0024 17.6 0.4 3.0 2 1 0 2 2 2 1 Serglycin EF-hand_7 PF13499.1 CDI78530.1 - 0.0056 16.7 0.1 0.48 10.5 0.0 3.7 3 1 1 4 4 4 1 EF-hand domain pair AAA_23 PF13476.1 CDI78530.1 - 0.16 12.2 15.0 0.93 9.7 1.3 2.4 2 0 0 2 2 2 0 AAA domain DHHW PF14286.1 CDI78530.1 - 1.2 8.4 13.0 2.3 7.4 0.2 3.0 3 0 0 3 3 3 0 DHHW protein Suf PF05843.9 CDI78530.1 - 2.3 7.8 31.3 0.66 9.6 4.7 3.3 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Tim54 PF11711.3 CDI78530.1 - 2.4 6.6 10.2 2.8 6.4 0.7 2.8 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 Spt20 PF12090.3 CDI78530.1 - 5 6.4 21.5 0.16 11.2 2.0 3.0 3 0 0 3 3 3 0 Spt20 family Med3 PF11593.3 CDI78531.1 - 0.0031 16.8 3.0 0.0031 16.8 2.1 1.6 1 1 1 2 2 2 1 Mediator complex subunit 3 fungal DUF755 PF05501.6 CDI78533.1 - 0.0034 17.4 8.7 0.0034 17.4 6.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF755) RAP PF08373.5 CDI78533.1 - 0.034 13.9 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 RAP domain PAN_1 PF00024.21 CDI78535.1 - 9.6e-65 214.3 74.8 8.8e-08 31.8 1.4 11.2 7 4 4 11 11 11 11 PAN domain PAN_4 PF14295.1 CDI78535.1 - 4.4e-51 170.3 65.7 6.2e-06 25.8 0.4 11.8 11 1 0 11 11 11 11 PAN domain PAN_2 PF08276.6 CDI78535.1 - 9e-13 47.8 70.9 0.0061 16.3 0.4 11.8 11 1 0 11 11 11 8 PAN-like domain PAN_3 PF08277.7 CDI78535.1 - 0.82 9.3 59.0 0.25 10.9 0.4 10.7 11 0 0 11 11 11 0 PAN-like domain Ras PF00071.17 CDI78537.1 - 6.8e-05 22.3 0.0 8.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Ras family YbaB_DNA_bd PF02575.11 CDI78537.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 YbaB/EbfC DNA-binding family PAP_assoc PF03828.14 CDI78539.1 - 0.26 11.2 0.0 1.3 9.0 0.0 2.1 2 0 0 2 2 2 0 Cid1 family poly A polymerase Activator_LAG-3 PF11498.3 CDI78539.1 - 2.9 6.5 28.8 5.5 5.6 20.0 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF966 PF06136.8 CDI78540.1 - 0.013 14.9 5.7 0.017 14.5 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SAPS PF04499.10 CDI78540.1 - 0.2 10.2 1.1 0.24 10.0 0.7 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Tim54 PF11711.3 CDI78540.1 - 0.26 9.8 2.2 0.4 9.2 1.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.12 CDI78540.1 - 0.48 9.1 2.3 0.58 8.9 1.6 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.4 CDI78540.1 - 0.51 8.5 10.0 0.67 8.1 6.9 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF566 PF04484.7 CDI78540.1 - 0.81 9.1 13.4 1.2 8.6 9.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) BAF1_ABF1 PF04684.8 CDI78540.1 - 0.99 8.1 8.4 1.4 7.6 5.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DNA_pol_viral_N PF00242.12 CDI78540.1 - 1 8.2 8.2 1.4 7.8 5.7 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain TFIIF_alpha PF05793.7 CDI78540.1 - 1 7.6 12.5 1.7 6.9 8.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.4 CDI78540.1 - 1.4 8.3 27.5 0.15 11.5 15.9 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Med3 PF11593.3 CDI78540.1 - 2 7.5 7.4 2.8 7.1 5.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4604 PF15377.1 CDI78540.1 - 2.6 8.2 19.5 0.19 11.9 9.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) RAP1 PF07218.6 CDI78540.1 - 5.4 4.9 11.8 6.6 4.6 8.2 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DHHW PF14286.1 CDI78540.1 - 5.9 6.0 7.1 9.3 5.4 4.9 1.3 1 0 0 1 1 1 0 DHHW protein Med19 PF10278.4 CDI78540.1 - 6.4 6.4 7.8 1.7 8.2 2.7 1.8 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Golgin_A5 PF09787.4 CDI78540.1 - 7.1 5.0 11.7 10 4.4 8.1 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 LRR_4 PF12799.2 CDI78542.1 - 1.8e-41 139.1 51.5 4.8e-06 26.0 0.3 13.3 7 4 10 17 17 17 15 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI78542.1 - 8.4e-35 118.3 49.6 5.4e-06 26.0 2.0 10.7 9 2 2 11 11 11 8 Leucine rich repeat LRR_9 PF14580.1 CDI78542.1 - 1.7e-24 86.3 5.6 2.7e-11 43.3 0.0 5.4 5 0 0 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.1 CDI78542.1 - 4.1e-09 35.5 37.8 0.5 10.5 0.0 14.1 14 2 1 15 15 15 3 Leucine Rich repeat LRR_1 PF00560.28 CDI78542.1 - 1e-08 33.9 52.3 0.19 11.9 0.0 15.9 18 1 0 18 18 18 4 Leucine Rich Repeat LRR_7 PF13504.1 CDI78542.1 - 3 8.4 65.6 9.9 6.8 0.1 15.5 18 0 0 18 18 18 0 Leucine rich repeat Serglycin PF04360.7 CDI78544.1 - 5.1 6.8 15.0 14 5.4 10.4 2.1 1 1 0 1 1 1 0 Serglycin RAP1 PF07218.6 CDI78544.1 - 5.4 4.9 12.2 6 4.8 8.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.4 CDI78544.1 - 5.5 5.1 11.3 6.5 4.9 7.9 1.0 1 0 0 1 1 1 0 Transmembrane protein SpoIID PF08486.5 CDI78544.1 - 6.9 7.0 8.6 52 4.2 6.0 2.2 1 1 0 1 1 1 0 Stage II sporulation protein OmpH PF03938.9 CDI78546.1 - 0.0018 18.2 10.7 0.0018 18.2 7.4 12.8 6 4 3 9 9 9 1 Outer membrane protein (OmpH-like) RskA PF10099.4 CDI78547.1 - 0.0033 17.1 6.4 0.0046 16.7 4.5 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Serinc PF03348.10 CDI78547.1 - 0.19 10.3 5.3 0.18 10.4 3.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Shadoo PF14999.1 CDI78547.1 - 0.34 10.7 5.1 0.38 10.5 3.6 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective FimP PF09766.4 CDI78547.1 - 0.45 9.5 15.7 0.4 9.7 10.9 1.1 1 0 0 1 1 1 0 Fms-interacting protein Ribosomal_60s PF00428.14 CDI78547.1 - 0.51 10.7 12.4 0.79 10.1 8.6 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Hamartin PF04388.7 CDI78547.1 - 0.61 8.6 8.2 0.6 8.7 5.7 1.0 1 0 0 1 1 1 0 Hamartin protein Flavodoxin_2 PF02525.12 CDI78547.1 - 0.75 9.2 7.2 0.88 9.0 5.0 1.1 1 0 0 1 1 1 0 Flavodoxin-like fold Suf PF05843.9 CDI78547.1 - 0.88 9.2 13.0 0.92 9.1 9.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med15 PF09606.5 CDI78547.1 - 1.1 7.4 32.0 1.1 7.3 22.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.3 CDI78547.1 - 1.1 8.5 9.2 1.2 8.4 6.4 1.3 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.4 CDI78547.1 - 1.6 6.9 24.3 1.5 6.9 16.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Usp PF00582.21 CDI78547.1 - 4.4 7.4 5.7 9.4 6.4 3.9 1.6 1 1 0 1 1 1 0 Universal stress protein family Conotoxin PF02950.12 CDI78547.1 - 7.7 7.3 7.9 4 8.3 3.3 2.0 2 0 0 2 2 2 0 Conotoxin DUF2052 PF09747.4 CDI78548.1 - 0.24 11.2 18.5 3.8 7.4 9.6 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4638 PF15472.1 CDI78548.1 - 0.72 9.4 4.9 1.6 8.2 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DDHD PF02862.12 CDI78548.1 - 1.4 8.6 13.2 3.9 7.1 5.7 2.7 2 0 0 2 2 2 0 DDHD domain Tim54 PF11711.3 CDI78548.1 - 3.4 6.1 8.5 8.7 4.8 5.9 1.6 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ctr PF04145.10 CDI78548.1 - 6.3 6.8 10.8 9 6.3 4.7 2.9 2 0 0 2 2 2 0 Ctr copper transporter family Band_3_cyto PF07565.8 CDI78548.1 - 9.1 5.7 14.0 6.5 6.1 5.5 2.6 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF3275 PF11679.3 CDI78549.1 - 0.065 12.8 0.4 0.071 12.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) DUF3597 PF12200.3 CDI78549.1 - 0.13 12.6 1.4 0.19 12.1 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Ribosomal_60s PF00428.14 CDI78549.1 - 0.17 12.3 4.0 0.25 11.7 2.8 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Med3 PF11593.3 CDI78549.1 - 0.25 10.5 2.4 0.24 10.6 1.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PepSY_2 PF13670.1 CDI78549.1 - 1.2 9.1 4.4 1.9 8.4 3.1 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain IMCp PF12314.3 CDI78550.1 - 1.9e-18 66.4 52.0 7e-14 51.7 19.0 2.1 1 1 1 2 2 2 2 Inner membrane complex protein IMCp PF12314.3 CDI78551.1 - 2.1e-26 91.9 52.6 1.5e-25 89.1 25.4 2.2 1 1 2 3 3 3 3 Inner membrane complex protein GHMP_kinases_N PF00288.21 CDI78554.1 - 0.00039 20.4 0.0 0.00039 20.4 0.0 6.8 7 1 1 8 8 8 1 GHMP kinases N terminal domain Ground-like PF04155.13 CDI78554.1 - 0.015 15.6 2.8 0.12 12.6 2.0 2.7 1 0 0 1 1 1 0 Ground-like domain Aminotran_5 PF00266.14 CDI78556.1 - 3.7e-17 62.1 0.0 7.2e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V SR-25 PF10500.4 CDI78556.1 - 2.3e-06 27.2 10.0 3.2e-06 26.8 6.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Tmemb_cc2 PF10267.4 CDI78556.1 - 0.00096 17.8 4.1 0.0013 17.3 2.8 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein CAF-1_p150 PF11600.3 CDI78556.1 - 0.048 13.0 13.5 0.07 12.5 9.3 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Corona_nucleoca PF00937.13 CDI78556.1 - 0.092 11.6 11.6 0.056 12.3 4.5 2.6 3 1 1 4 4 4 0 Coronavirus nucleocapsid protein Band_3_cyto PF07565.8 CDI78556.1 - 0.24 10.8 5.5 0.37 10.2 3.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Gti1_Pac2 PF09729.4 CDI78556.1 - 0.27 11.0 6.3 0.5 10.2 4.4 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family BTV_NS2 PF04514.7 CDI78558.1 - 0.0089 14.9 4.0 0.014 14.3 2.7 1.2 1 0 0 1 1 1 1 Bluetongue virus non-structural protein NS2 MFS_1 PF07690.11 CDI78558.1 - 0.23 10.1 16.3 1.3 7.6 0.8 2.2 2 0 0 2 2 2 0 Major Facilitator Superfamily PXA PF02194.10 CDI78558.1 - 0.26 10.8 2.7 0.46 10.0 1.9 1.4 1 0 0 1 1 1 0 PXA domain DUF2721 PF11026.3 CDI78558.1 - 0.61 9.7 9.1 0.09 12.4 0.8 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Ctr PF04145.10 CDI78558.1 - 1.5 8.8 3.3 4.5 7.3 0.5 2.9 2 1 0 2 2 2 0 Ctr copper transporter family Mus7 PF09462.5 CDI78558.1 - 2 7.1 13.1 2.9 6.6 9.1 1.2 1 0 0 1 1 1 0 Mus7/MMS22 family DDHD PF02862.12 CDI78558.1 - 2 8.1 6.4 3.8 7.2 4.4 1.5 1 0 0 1 1 1 0 DDHD domain SID-1_RNA_chan PF13965.1 CDI78558.1 - 3 5.8 5.1 5.1 5.1 3.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EphA2_TM PF14575.1 CDI78560.1 - 0.015 15.6 0.1 2.7 8.4 0.0 3.4 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain CcmH PF03918.9 CDI78560.1 - 0.13 11.2 1.0 3.1 6.7 0.0 2.8 3 0 0 3 3 3 0 Cytochrome C biogenesis protein DUF308 PF03729.8 CDI78560.1 - 1.1 9.2 10.9 0.03 14.3 1.7 2.6 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) RseC_MucC PF04246.7 CDI78560.1 - 3.3 7.2 7.7 0.4 10.2 0.1 3.0 3 1 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DUF3742 PF12553.3 CDI78560.1 - 6.7 7.2 0.0 6.7 7.2 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF3742) zf-met2 PF12907.2 CDI78564.1 - 0.39 10.7 3.0 0.51 10.3 0.0 2.6 2 0 0 2 2 2 0 Zinc-binding Peptidase_C58 PF03543.9 CDI78564.1 - 5.3 6.4 11.6 0.33 10.4 0.2 2.6 3 0 0 3 3 3 0 Yersinia/Haemophilus virulence surface antigen Cnd1 PF12717.2 CDI78565.1 - 0.00083 19.2 0.8 0.053 13.3 0.0 3.4 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CDI78565.1 - 0.7 10.1 9.5 27 5.1 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat CENP-Q PF13094.1 CDI78565.1 - 3.9 7.4 8.5 14 5.6 0.3 3.2 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit WD40 PF00400.27 CDI78566.1 - 6.8e-05 22.5 2.5 0.021 14.7 0.1 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 CDI78566.1 - 0.0045 15.8 0.3 0.0045 15.8 0.2 1.7 2 0 0 2 2 2 1 Coatomer WD associated region TPR_7 PF13176.1 CDI78566.1 - 0.07 12.9 0.4 2.1 8.3 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat RIX1 PF08167.7 CDI78568.1 - 0.011 15.4 2.9 0.029 14.0 0.5 2.8 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis Keratin_assoc PF09775.4 CDI78568.1 - 0.12 11.8 0.1 0.26 10.8 0.1 1.5 1 0 0 1 1 1 0 Keratinocyte-associated protein 2 YHS PF04945.8 CDI78570.1 - 0.08 12.8 0.0 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 YHS domain HAD_2 PF13419.1 CDI78570.1 - 0.15 12.2 0.1 0.89 9.7 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase AMA-1 PF02430.10 CDI78572.1 - 8.2e-67 226.0 0.4 1.2e-66 225.4 0.3 1.2 1 0 0 1 1 1 1 Apical membrane antigen 1 Lamp PF01299.12 CDI78572.1 - 0.014 14.5 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) WD40 PF00400.27 CDI78573.1 - 8.9e-11 41.2 17.6 7.8e-10 38.2 0.0 5.4 6 1 0 6 6 6 3 WD domain, G-beta repeat DUF4205 PF13898.1 CDI78574.1 - 1.1e-31 109.8 0.1 1.1e-30 106.5 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4205) CoA_transf_3 PF02515.12 CDI78575.1 - 0.031 13.5 9.7 0.038 13.2 6.7 1.1 1 0 0 1 1 1 0 CoA-transferase family III Tetraspannin PF00335.15 CDI78575.1 - 0.32 10.2 4.0 0.38 9.9 2.7 1.1 1 0 0 1 1 1 0 Tetraspanin family Neur_chan_memb PF02932.11 CDI78575.1 - 0.8 9.5 9.8 0.95 9.3 6.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TGF_beta PF00019.15 CDI78575.1 - 1.3 9.3 5.4 1.7 8.9 3.3 1.5 1 1 0 1 1 1 0 Transforming growth factor beta like domain DNA_pol_viral_N PF00242.12 CDI78575.1 - 9.5 5.1 22.7 10 5.0 15.7 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain BRF1 PF07741.8 CDI78576.1 - 0.15 12.3 0.3 0.25 11.5 0.2 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain LZ_Tnp_IS66 PF13007.2 CDI78576.1 - 0.29 11.7 3.8 0.47 11.1 2.6 1.2 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain Ribosomal_60s PF00428.14 CDI78576.1 - 1.7 9.0 13.9 0.085 13.2 4.9 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein MMR_HSR1 PF01926.18 CDI78577.1 - 6.9e-13 48.5 0.1 2e-12 47.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP1_OBG PF01018.17 CDI78577.1 - 2.9e-08 33.5 11.9 3.9e-05 23.3 1.5 3.6 3 0 0 3 3 3 2 GTP1/OBG FeoB_N PF02421.13 CDI78577.1 - 2.5e-05 23.5 0.0 0.0001 21.6 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B PH_4 PF15404.1 CDI78577.1 - 0.005 16.4 3.0 0.005 16.4 2.1 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain AAA_25 PF13481.1 CDI78577.1 - 0.013 14.8 0.1 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Myticin-prepro PF10690.4 CDI78577.1 - 0.46 10.5 9.3 0.97 9.4 5.4 2.4 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel Tetraspannin PF00335.15 CDI78578.1 - 0.061 12.5 0.0 0.1 11.8 0.0 1.3 1 1 0 1 1 1 0 Tetraspanin family CRPA PF05745.6 CDI78578.1 - 0.31 10.8 1.5 0.6 9.9 1.0 1.4 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) IncA PF04156.9 CDI78578.1 - 0.74 9.3 9.6 0.16 11.5 0.1 2.3 2 0 0 2 2 2 0 IncA protein Ribosomal_L4 PF00573.17 CDI78579.1 - 1e-09 38.0 1.7 1.1e-06 28.2 0.2 2.8 1 1 2 3 3 3 2 Ribosomal protein L4/L1 family HSP20 PF00011.16 CDI78582.1 - 2.5e-12 46.5 0.0 3.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family SurE PF01975.12 CDI78583.1 - 0.54 9.5 10.9 0.081 12.2 1.2 2.7 2 0 0 2 2 2 0 Survival protein SurE NTR2 PF15458.1 CDI78585.1 - 0.0015 17.8 6.0 0.0015 17.8 4.1 2.2 2 0 0 2 2 2 1 Nineteen complex-related protein 2 AAA_23 PF13476.1 CDI78585.1 - 0.089 13.1 6.5 5 7.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Secretin_N_2 PF07655.8 CDI78585.1 - 0.11 12.8 11.4 0.18 12.2 0.2 2.6 3 0 0 3 3 3 0 Secretin N-terminal domain Activator_LAG-3 PF11498.3 CDI78585.1 - 1.7 7.3 47.5 0.71 8.5 19.7 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF2489 PF10675.4 CDI78586.1 - 0.0022 17.6 1.4 0.003 17.2 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2489) DUF966 PF06136.8 CDI78586.1 - 0.0026 17.2 23.0 0.0033 16.8 15.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF966) DivIC PF04977.10 CDI78586.1 - 0.09 12.2 10.2 0.13 11.7 7.1 1.2 1 0 0 1 1 1 0 Septum formation initiator Suf PF05843.9 CDI78586.1 - 0.55 9.9 14.6 0.14 11.8 3.5 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Hid1 PF12722.2 CDI78586.1 - 0.87 7.1 19.5 1.1 6.7 13.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF572 PF04502.8 CDI78586.1 - 4.4 6.4 22.5 7.1 5.7 15.6 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF572) DUF2140 PF09911.4 CDI78586.1 - 9.4 5.3 7.5 0.56 9.3 0.5 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) FimP PF09766.4 CDI78586.1 - 9.5 5.1 13.3 0.43 9.6 5.4 1.4 2 0 0 2 2 2 0 Fms-interacting protein Amino_oxidase PF01593.19 CDI78587.1 - 7.5e-32 110.9 35.7 1.1e-19 70.8 4.7 4.8 4 1 0 4 4 4 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CDI78587.1 - 1.6e-14 53.6 5.9 2e-14 53.3 0.6 3.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 CDI78587.1 - 0.00026 21.3 0.8 0.0047 17.3 0.7 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI78587.1 - 0.0009 18.4 0.1 0.0023 17.0 0.1 1.6 1 0 0 1 1 1 1 Thi4 family N6_N4_Mtase PF01555.13 CDI78589.1 - 0.0028 17.1 0.0 0.34 10.3 0.0 3.1 3 2 0 3 3 3 2 DNA methylase NifU PF01106.12 CDI78591.1 - 3.8e-11 42.6 1.0 8.8e-06 25.4 0.2 3.6 2 2 0 2 2 2 2 NifU-like domain DUF4366 PF14283.1 CDI78591.1 - 0.047 13.1 3.5 1.2 8.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Sporozoite_P67 PF05642.6 CDI78592.1 - 0.0011 16.9 4.6 0.0011 16.9 3.2 7.2 5 3 1 6 6 6 2 Sporozoite P67 surface antigen SAPS PF04499.10 CDI78592.1 - 0.013 14.2 0.2 0.013 14.2 0.1 4.3 5 0 0 5 5 5 0 SIT4 phosphatase-associated protein LMBR1 PF04791.11 CDI78592.1 - 0.12 10.9 8.3 1.2 7.6 0.0 2.8 3 0 0 3 3 3 0 LMBR1-like membrane protein zf-RING_2 PF13639.1 CDI78593.1 - 0.00075 19.2 2.1 0.002 17.8 1.5 1.8 1 0 0 1 1 1 1 Ring finger domain CDK2AP PF09806.4 CDI78593.1 - 0.0041 17.3 2.7 0.0041 17.3 1.8 27.8 13 9 6 21 21 21 3 Cyclin-dependent kinase 2-associated protein Peptidase_S8 PF00082.17 CDI78596.1 - 1.2e-19 70.6 6.6 1.5e-19 70.2 4.6 1.1 1 0 0 1 1 1 1 Subtilase family Atrophin-1 PF03154.10 CDI78596.1 - 0.25 9.4 3.1 0.38 8.8 2.1 1.2 1 0 0 1 1 1 0 Atrophin-1 family CDC45 PF02724.9 CDI78596.1 - 0.77 7.7 4.7 0.99 7.3 3.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Linocin_M18 PF04454.7 CDI78597.1 - 0.066 12.1 0.1 0.066 12.1 0.1 1.7 2 0 0 2 2 2 0 Encapsulating protein for peroxidase TFIIF_alpha PF05793.7 CDI78597.1 - 1.4 7.2 12.9 2.5 6.3 9.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Hamartin PF04388.7 CDI78597.1 - 3.5 6.1 23.1 0.56 8.8 10.5 2.2 2 0 0 2 2 2 0 Hamartin protein DUF883 PF05957.8 CDI78598.1 - 2.9 8.3 10.5 0.21 12.0 3.3 1.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ycf1 PF05758.7 CDI78599.1 - 0.29 8.8 10.6 0.33 8.6 7.3 1.1 1 0 0 1 1 1 0 Ycf1 RPOL_N PF14700.1 CDI78599.1 - 0.51 9.5 3.8 0.58 9.3 2.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal Hid1 PF12722.2 CDI78599.1 - 8.5 3.9 8.7 8 3.9 6.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AFG1_ATPase PF03969.11 CDI78600.1 - 1.1e-44 152.7 0.0 1.6e-44 152.2 0.0 1.1 1 0 0 1 1 1 1 AFG1-like ATPase Pro-rich PF15240.1 CDI78600.1 - 0.0028 17.7 19.3 0.0044 17.1 13.4 1.3 1 0 0 1 1 1 1 Proline-rich DUF1674 PF07896.7 CDI78601.1 - 3.3e-11 43.1 1.6 8.9e-11 41.8 1.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) U1snRNP70_N PF12220.3 CDI78601.1 - 0.0072 16.6 7.3 0.014 15.6 5.1 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SARG PF15385.1 CDI78601.1 - 0.023 14.0 16.4 0.031 13.6 11.4 1.1 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein DUF605 PF04652.11 CDI78601.1 - 0.13 11.5 24.8 0.18 11.2 17.2 1.1 1 0 0 1 1 1 0 Vta1 like zf-DHHC PF01529.15 CDI78601.1 - 0.14 11.5 0.2 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase FimP PF09766.4 CDI78601.1 - 1.2 8.1 12.5 1.6 7.6 8.7 1.1 1 0 0 1 1 1 0 Fms-interacting protein PAT1 PF09770.4 CDI78601.1 - 1.2 7.2 28.3 1.5 6.9 19.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3464 PF11947.3 CDI78601.1 - 1.5 8.2 5.8 53 3.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3464) Hamartin PF04388.7 CDI78601.1 - 2 6.9 12.7 2.4 6.7 8.8 1.1 1 0 0 1 1 1 0 Hamartin protein Mito_fiss_reg PF05308.6 CDI78601.1 - 4.8 6.4 17.5 6.8 5.9 12.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF2868 PF11067.3 CDI78601.1 - 5.7 5.9 11.0 7.3 5.6 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) BAF1_ABF1 PF04684.8 CDI78601.1 - 9 5.0 15.9 13 4.4 11.0 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4175 PF13779.1 CDI78601.1 - 9.1 3.8 19.9 13 3.2 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.8 CDI78601.1 - 9.2 6.0 23.8 12 5.6 16.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SNARE PF05739.14 CDI78602.1 - 1.3e-12 47.1 3.0 2.4e-12 46.3 2.1 1.4 1 0 0 1 1 1 1 SNARE domain DUF148 PF02520.12 CDI78602.1 - 0.0036 17.0 2.5 0.044 13.5 0.4 2.4 2 1 0 2 2 2 1 Domain of unknown function DUF148 DUF3461 PF11944.3 CDI78602.1 - 0.021 14.6 1.2 0.42 10.4 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3461) FliG_M PF14841.1 CDI78602.1 - 0.084 12.8 0.6 0.63 10.0 0.1 2.4 2 1 1 3 3 3 0 FliG middle domain Tup_N PF08581.5 CDI78602.1 - 0.094 12.9 0.5 0.094 12.9 0.4 2.3 2 2 0 2 2 2 0 Tup N-terminal Vac_Fusion PF02346.11 CDI78602.1 - 0.095 12.1 1.7 5.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Chordopoxvirus fusion protein M20_dimer PF07687.9 CDI78602.1 - 0.11 12.2 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Peptidase dimerisation domain HAP1_N PF04849.8 CDI78602.1 - 0.74 8.7 4.5 1.7 7.4 0.7 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DUF2512 PF10710.4 CDI78606.1 - 0.26 10.7 0.0 0.26 10.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2512) TRAP-gamma PF07074.7 CDI78606.1 - 0.49 9.9 3.0 4.7 6.6 1.3 2.7 3 0 0 3 3 3 0 Translocon-associated protein, gamma subunit (TRAP-gamma) tRNA-synt_1d PF00750.14 CDI78607.1 - 1.6e-101 339.6 0.0 2.4e-101 339.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 CDI78607.1 - 1.9e-25 89.1 0.0 5.5e-25 87.6 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 CDI78607.1 - 1.1e-12 48.2 0.0 4e-12 46.4 0.0 2.0 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1 PF00133.17 CDI78607.1 - 0.025 12.6 0.0 0.036 12.0 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 CDI78607.1 - 0.033 13.2 0.0 0.06 12.4 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DapB_N PF01113.15 CDI78607.1 - 0.042 13.7 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Neur_chan_memb PF02932.11 CDI78608.1 - 4.4 7.1 7.8 2.5 7.9 0.4 2.3 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region LSM PF01423.17 CDI78610.1 - 0.00092 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 LSM domain DUF1635 PF07795.6 CDI78610.1 - 0.92 8.8 14.3 0.03 13.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Secretin_N_2 PF07655.8 CDI78610.1 - 1.6 9.1 22.1 1.6 9.1 0.7 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3446 PF11928.3 CDI78610.1 - 2.6 8.2 26.5 0.2 11.8 1.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) TraU PF06834.6 CDI78612.1 - 0.00064 18.9 6.7 0.015 14.4 0.0 2.9 2 1 0 2 2 2 2 TraU protein DUF912 PF06024.7 CDI78612.1 - 0.1 12.6 6.1 9.1 6.4 0.0 3.6 4 0 0 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) GntP_permease PF02447.11 CDI78612.1 - 0.24 9.8 1.1 0.74 8.2 0.1 2.1 3 0 0 3 3 3 0 GntP family permease DUF4407 PF14362.1 CDI78612.1 - 3.1 6.6 16.8 1.2 8.0 4.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SR-25 PF10500.4 CDI78613.1 - 0.0034 16.8 4.4 0.0034 16.8 3.1 12.1 8 2 2 11 11 11 2 Nuclear RNA-splicing-associated protein CAF1 PF04857.15 CDI78614.1 - 4.2e-14 52.5 6.8 2.7e-09 36.7 0.0 3.2 2 1 1 3 3 3 2 CAF1 family ribonuclease SR-25 PF10500.4 CDI78614.1 - 0.0013 18.2 13.5 0.0013 18.2 9.3 5.1 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein Ycf1 PF05758.7 CDI78614.1 - 0.021 12.5 5.9 0.029 12.1 4.1 1.2 1 0 0 1 1 1 0 Ycf1 Peptidase_S49_N PF08496.5 CDI78614.1 - 0.07 12.9 11.1 20 4.9 9.1 2.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FB_lectin PF07367.6 CDI78614.1 - 0.41 10.2 3.0 0.94 9.0 2.1 1.6 1 0 0 1 1 1 0 Fungal fruit body lectin Spore_coat_CotO PF14153.1 CDI78614.1 - 1.1 8.6 23.4 0.46 9.9 12.1 2.5 2 0 0 2 2 2 0 Spore coat protein CotO Cwf_Cwc_15 PF04889.7 CDI78614.1 - 6.4 6.4 39.0 0.53 9.9 16.5 2.9 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Mgr1 PF08602.5 CDI78614.1 - 7.1 5.5 10.2 13 4.6 7.1 1.4 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit WD40 PF00400.27 CDI78615.1 - 4.9e-08 32.5 1.3 0.004 16.9 0.1 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat Apc4_WD40 PF12894.2 CDI78615.1 - 0.039 13.4 0.2 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain NUC205 PF08168.6 CDI78615.1 - 0.08 12.3 1.1 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 NUC205 domain Med3 PF11593.3 CDI78615.1 - 0.36 10.0 31.6 0.37 9.9 2.8 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Rifin_STEVOR PF02009.11 CDI78615.1 - 7.8 6.0 6.6 0.93 9.0 0.6 1.9 2 0 0 2 2 2 0 Rifin/stevor family PH PF00169.24 CDI78616.1 - 0.091 12.9 0.0 11 6.3 0.0 2.2 1 1 0 2 2 2 0 PH domain bZIP_1 PF00170.16 CDI78616.1 - 0.098 12.6 0.1 0.22 11.4 0.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor BAF1_ABF1 PF04684.8 CDI78617.1 - 1.2e-05 24.4 7.8 1.2e-05 24.4 5.4 6.3 4 2 0 5 5 5 1 BAF1 / ABF1 chromatin reorganising factor DUF327 PF03885.8 CDI78618.1 - 0.014 15.2 5.8 0.014 15.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF327) CitG PF01874.11 CDI78618.1 - 0.04 13.1 0.8 0.063 12.4 0.1 1.6 2 0 0 2 2 2 0 ATP:dephospho-CoA triphosphoribosyl transferase Androgen_recep PF02166.11 CDI78618.1 - 0.054 12.3 6.8 0.064 12.1 4.7 1.1 1 0 0 1 1 1 0 Androgen receptor Med3 PF11593.3 CDI78618.1 - 0.39 9.9 9.9 0.55 9.4 6.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PAPS_reduct PF01507.14 CDI78619.1 - 3.7e-16 59.4 8.5 2.2e-14 53.6 5.9 3.1 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Ycf1 PF05758.7 CDI78619.1 - 0.00054 17.8 3.8 0.00062 17.6 2.6 1.1 1 0 0 1 1 1 1 Ycf1 Hid1 PF12722.2 CDI78619.1 - 0.0014 16.4 8.8 0.0017 16.1 6.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Pex14_N PF04695.8 CDI78619.1 - 0.006 16.6 11.7 0.006 16.6 8.1 2.8 3 0 0 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_11 PF13086.1 CDI78619.1 - 0.0066 16.0 10.1 0.0096 15.5 7.0 1.2 1 0 0 1 1 1 1 AAA domain YqfQ PF14181.1 CDI78619.1 - 0.011 15.8 9.6 0.011 15.8 6.6 2.6 3 0 0 3 3 3 0 YqfQ-like protein Zip PF02535.17 CDI78619.1 - 0.02 13.9 11.9 0.035 13.1 8.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.5 CDI78619.1 - 0.02 13.3 7.2 0.025 13.0 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Otopetrin PF03189.8 CDI78619.1 - 0.056 12.4 3.7 0.08 11.9 2.5 1.2 1 0 0 1 1 1 0 Otopetrin Spore_YhcN_YlaJ PF09580.5 CDI78619.1 - 0.2 11.7 11.2 0.29 11.2 7.7 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) SeqA PF03925.8 CDI78619.1 - 0.35 10.5 10.2 2.4 7.8 7.5 1.8 2 0 0 2 2 2 0 SeqA protein RP-C_C PF11800.3 CDI78619.1 - 0.49 10.0 14.5 0.13 11.9 6.4 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF4220 PF13968.1 CDI78619.1 - 0.52 9.3 4.3 0.76 8.8 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Mem_trans PF03547.13 CDI78619.1 - 0.54 8.4 1.8 0.94 7.7 1.3 1.3 1 0 0 1 1 1 0 Membrane transport protein Paramyxo_ncap PF00973.14 CDI78619.1 - 0.75 8.4 10.1 0.97 8.0 7.0 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4045 PF13254.1 CDI78619.1 - 1.3 8.2 13.4 0.61 9.3 7.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Tim54 PF11711.3 CDI78619.1 - 1.5 7.3 9.7 0.71 8.4 4.4 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Spore_coat_CotO PF14153.1 CDI78619.1 - 2.1 7.7 24.3 0.026 13.9 11.4 1.7 2 0 0 2 2 2 0 Spore coat protein CotO FliP PF00813.15 CDI78619.1 - 2.4 7.7 6.5 3.7 7.2 3.4 1.9 2 0 0 2 2 2 0 FliP family RR_TM4-6 PF06459.7 CDI78619.1 - 2.5 7.9 15.2 4.9 6.9 10.1 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF1510 PF07423.6 CDI78619.1 - 2.5 7.4 18.9 0.11 11.8 9.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) BORG_CEP PF14957.1 CDI78619.1 - 2.6 8.9 10.1 0.26 12.2 2.8 2.1 2 0 0 2 2 2 0 Cdc42 effector Peptidase_U57 PF05582.7 CDI78619.1 - 5 6.0 13.3 7.5 5.4 9.2 1.2 1 0 0 1 1 1 0 YabG peptidase U57 DHHW PF14286.1 CDI78619.1 - 8.1 5.6 11.7 0.12 11.6 3.2 1.5 2 0 0 2 2 2 0 DHHW protein DUF4446 PF14584.1 CDI78619.1 - 8.2 6.2 10.3 16 5.2 7.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Cwf_Cwc_15 PF04889.7 CDI78620.1 - 0.00021 21.0 4.9 0.00021 21.0 3.4 2.0 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein zf-HIT PF04438.11 CDI78620.1 - 0.00056 19.4 11.3 0.00091 18.8 7.8 1.3 1 0 0 1 1 1 1 HIT zinc finger Nipped-B_C PF12830.2 CDI78620.1 - 0.051 13.2 0.6 0.09 12.4 0.1 1.6 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus DUF2367 PF10164.4 CDI78620.1 - 0.16 11.8 1.8 0.39 10.5 1.2 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) DUF382 PF04037.8 CDI78621.1 - 0.046 13.5 0.3 7.2 6.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF382) GHMP_kinases_C PF08544.8 CDI78621.1 - 0.11 12.7 0.0 2 8.6 0.0 2.6 2 1 0 2 2 2 0 GHMP kinases C terminal TENA_THI-4 PF03070.11 CDI78621.1 - 0.19 11.4 2.5 4.8 6.8 0.1 2.4 2 0 0 2 2 2 0 TENA/THI-4/PQQC family Cas_APE2256 PF09651.5 CDI78621.1 - 0.27 10.9 1.6 8.6 6.0 0.0 2.7 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_APE2256) DUF3294 PF07957.6 CDI78621.1 - 3.6 7.0 8.5 3.2 7.2 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3294) MIF4G PF02854.14 CDI78622.1 - 5.5e-22 78.2 1.1 6.3e-22 78.0 0.0 1.7 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.12 CDI78622.1 - 1e-07 31.6 1.7 2.4e-07 30.4 1.2 1.6 1 0 0 1 1 1 1 MA3 domain Phtf-FEM1B_bdg PF12129.3 CDI78622.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor F-box-like PF12937.2 CDI78623.1 - 0.00024 20.7 3.6 0.00095 18.8 2.5 2.1 1 0 0 1 1 1 1 F-box-like Myb_DNA-binding PF00249.26 CDI78624.1 - 8e-07 29.0 1.0 1.4e-06 28.2 0.7 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Neurensin PF14927.1 CDI78625.1 - 0.43 9.9 2.2 0.51 9.7 0.0 2.1 2 1 0 2 2 2 0 Neurensin DUF4355 PF14265.1 CDI78625.1 - 0.69 9.8 22.8 0.38 10.6 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) DUF2422 PF10337.4 CDI78625.1 - 1.4 7.5 9.1 1.9 7.2 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) DUF4228 PF14009.1 CDI78625.1 - 4.1 7.4 20.3 5.5 7.0 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) FHIPEP PF00771.15 CDI78625.1 - 4.9 5.3 18.5 32 2.6 12.8 1.8 1 1 0 1 1 1 0 FHIPEP family CAP_GLY PF01302.20 CDI78626.1 - 5.5e-09 35.6 0.4 1e-06 28.3 0.1 2.2 2 0 0 2 2 2 2 CAP-Gly domain ISN1 PF06437.6 CDI78626.1 - 0.17 10.5 1.1 0.22 10.2 0.7 1.1 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase MCR_alpha PF02249.12 CDI78626.1 - 7.8 6.5 9.3 6.7 6.7 1.7 2.4 2 0 0 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain SR-25 PF10500.4 CDI78627.1 - 0.0026 17.2 1.6 0.0026 17.2 1.1 6.7 5 3 2 7 7 7 1 Nuclear RNA-splicing-associated protein Glycos_transf_2 PF00535.21 CDI78628.1 - 3e-22 79.1 0.0 7.1e-22 77.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.17 CDI78628.1 - 2.3e-11 43.7 0.0 3.6e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.1 CDI78628.1 - 2.6e-10 40.5 0.0 4.1e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.9 CDI78628.1 - 1.9e-07 30.4 1.0 3.9e-07 29.4 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.4 CDI78628.1 - 5.3e-07 28.9 0.0 7.5e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 NTP_transf_3 PF12804.2 CDI78628.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain Glyco_transf_21 PF13506.1 CDI78628.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 GlcNAc PF11397.3 CDI78628.1 - 0.16 11.0 0.6 1 8.3 0.4 1.9 1 1 0 1 1 1 0 Glycosyltransferase (GlcNAc) DnaJ PF00226.26 CDI78629.1 - 1.3e-11 44.0 0.0 3.4e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain PAS PF00989.19 CDI78629.1 - 0.13 12.0 0.1 1.3 8.8 0.0 2.6 2 0 0 2 2 2 0 PAS fold Pkinase PF00069.20 CDI78630.1 - 2.8e-61 206.9 0.0 5.1e-61 206.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78630.1 - 5.8e-28 97.6 0.7 3.7e-27 95.0 0.5 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI78630.1 - 0.039 13.6 0.1 0.039 13.6 0.0 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family Metallophos PF00149.23 CDI78631.1 - 0.013 14.8 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase NAD_binding_6 PF08030.7 CDI78633.1 - 0.024 14.5 0.0 0.1 12.4 0.0 2.1 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Sin3_corepress PF08295.7 CDI78634.1 - 6.8e-19 67.4 0.2 1.9e-18 66.0 0.2 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor Spore_coat_CotO PF14153.1 CDI78634.1 - 0.52 9.7 21.9 0.23 10.8 1.7 2.7 1 1 1 2 2 2 0 Spore coat protein CotO Adaptin_binding PF10199.4 CDI78634.1 - 5.7 7.2 27.2 1.4e+02 2.7 17.0 3.7 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Laminin_G_3 PF13385.1 CDI78635.1 - 3.2e-18 66.4 0.0 5.3e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 CDI78635.1 - 1.6e-05 24.9 0.0 4.8e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.18 CDI78635.1 - 0.0025 17.8 0.0 0.0072 16.3 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain PI3_PI4_kinase PF00454.22 CDI78636.1 - 2.4e-28 99.2 0.0 1.1e-27 97.0 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 CDI78636.1 - 7.8e-11 41.2 0.0 2.1e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 FATC domain 7TM_GPCR_Srv PF10323.4 CDI78636.1 - 9.7 5.2 0.4 2e+02 0.9 0.0 2.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv Ribosomal_60s PF00428.14 CDI78639.1 - 0.013 15.8 4.3 0.026 14.8 3.0 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein AAA_23 PF13476.1 CDI78639.1 - 0.6 10.4 9.4 0.88 9.8 6.5 1.2 1 0 0 1 1 1 0 AAA domain Pneumo_att_G PF05539.6 CDI78639.1 - 6.2 6.0 8.9 7.6 5.8 6.2 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF2071 PF09844.4 CDI78640.1 - 0.31 10.4 2.7 0.2 11.0 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (COG2071) Macoilin PF09726.4 CDI78640.1 - 5.1 5.2 42.4 0.32 9.2 18.5 2.1 2 0 0 2 2 2 0 Transmembrane protein AAA_16 PF13191.1 CDI78642.1 - 0.0014 18.6 0.1 0.0023 17.9 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain Miro PF08477.8 CDI78642.1 - 0.023 15.1 0.0 0.31 11.5 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein AAA_33 PF13671.1 CDI78642.1 - 0.025 14.4 0.1 0.039 13.8 0.1 1.2 1 0 0 1 1 1 0 AAA domain Arf PF00025.16 CDI78642.1 - 0.16 11.2 0.0 3 7.0 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family PduV-EutP PF10662.4 CDI78642.1 - 0.17 11.3 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF3123 PF11321.3 CDI78642.1 - 0.8 10.0 4.9 1.4 9.1 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) Sugar_tr PF00083.19 CDI78643.1 - 7.6e-80 268.6 24.7 1.2e-79 267.9 17.1 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDI78643.1 - 3.3e-18 65.5 46.4 5e-15 55.0 13.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily GAGA_bind PF06217.7 CDI78643.1 - 2.5 7.9 16.8 4.2 7.2 11.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DNA_pol_viral_N PF00242.12 CDI78643.1 - 2.5 7.0 17.9 3.8 6.4 12.4 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF1675 PF07897.6 CDI78643.1 - 8.4 6.1 18.7 18 5.0 13.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Herpes_UL87 PF03043.9 CDI78645.1 - 0.00045 18.7 0.0 0.0011 17.5 0.0 1.5 1 1 0 1 1 1 1 Herpesvirus UL87 family Zip PF02535.17 CDI78645.1 - 0.012 14.5 3.3 0.12 11.3 0.2 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter SAGA-Tad1 PF12767.2 CDI78645.1 - 0.032 13.8 30.6 0.11 12.0 11.6 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Apt1 PF10351.4 CDI78645.1 - 0.044 12.6 0.1 0.044 12.6 0.0 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain CAF-1_p150 PF11600.3 CDI78645.1 - 0.11 11.8 34.8 0.15 11.4 13.2 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal FAIM1 PF06905.8 CDI78645.1 - 0.19 10.9 0.0 0.19 10.9 0.0 1.7 2 0 0 2 2 2 0 Fas apoptotic inhibitory molecule (FAIM1) TFIIA PF03153.8 CDI78645.1 - 0.24 11.2 64.8 0.45 10.3 9.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.5 CDI78645.1 - 0.66 8.1 118.0 0.91 7.6 54.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SPX PF03105.14 CDI78645.1 - 0.8 9.4 26.5 0.26 11.0 7.4 2.1 2 0 0 2 2 2 0 SPX domain GAGA_bind PF06217.7 CDI78645.1 - 0.87 9.4 30.7 1.5 8.7 12.4 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family DUF4045 PF13254.1 CDI78645.1 - 2.4 7.3 27.9 3.7 6.7 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) MRP-S31 PF15433.1 CDI78645.1 - 6 6.1 39.0 0.76 9.1 14.5 2.4 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S31 DDHD PF02862.12 CDI78645.1 - 6.4 6.4 30.9 5.4 6.7 10.7 2.1 2 0 0 2 2 2 0 DDHD domain DUF2052 PF09747.4 CDI78645.1 - 7 6.5 39.4 3.8 7.4 5.8 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.7 CDI78645.1 - 7.6 6.3 29.5 3.2 7.5 3.0 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Draxin PF15550.1 CDI78645.1 - 9.3 5.8 28.1 3.8 7.0 9.0 2.2 2 0 0 2 2 2 0 Draxin Herpes_UL87 PF03043.9 CDI78647.1 - 0.0019 16.6 0.2 0.01 14.2 0.0 1.9 1 1 1 2 2 2 1 Herpesvirus UL87 family zf-RING_2 PF13639.1 CDI78649.1 - 7.6e-07 28.8 15.4 1.3e-06 28.0 10.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 CDI78649.1 - 5.3e-06 26.2 14.2 1.7e-05 24.6 9.9 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CDI78649.1 - 3.3e-05 23.8 14.6 5.8e-05 23.0 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDI78649.1 - 0.00044 20.2 8.8 0.00088 19.3 6.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger Mem_trans PF03547.13 CDI78649.1 - 0.0022 16.3 2.5 0.0022 16.3 1.7 2.5 3 0 0 3 3 3 1 Membrane transport protein zf-RING_UBOX PF13445.1 CDI78649.1 - 0.0037 16.9 4.8 0.0037 16.9 3.3 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.1 CDI78649.1 - 0.004 16.7 15.6 0.0078 15.8 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI78649.1 - 0.005 16.4 15.7 0.0099 15.5 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SpoIIIAH PF12685.2 CDI78649.1 - 0.0064 16.0 0.8 0.0064 16.0 0.6 3.2 3 0 0 3 3 3 1 SpoIIIAH-like protein zf-RING_5 PF14634.1 CDI78649.1 - 0.012 15.2 16.7 0.058 13.1 11.8 2.0 1 1 1 2 2 2 0 zinc-RING finger domain DUF755 PF05501.6 CDI78649.1 - 0.023 14.7 18.8 0.023 14.7 13.0 6.3 4 3 1 5 5 2 0 Domain of unknown function (DUF755) zf-Apc11 PF12861.2 CDI78649.1 - 0.36 10.7 9.2 0.96 9.3 6.4 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Tim54 PF11711.3 CDI78649.1 - 9.9 4.6 11.3 4.9 5.6 5.5 2.1 2 1 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 WW PF00397.21 CDI78650.1 - 5e-09 35.8 2.9 8.2e-09 35.1 2.0 1.4 1 0 0 1 1 1 1 WW domain Yip1 PF04893.12 CDI78650.1 - 3.1e-05 23.5 12.8 8.7e-05 22.0 8.8 1.9 1 1 0 1 1 1 1 Yip1 domain Las1 PF04031.8 CDI78651.1 - 1.1e-23 83.5 0.0 1.1e-23 83.5 0.0 3.9 4 0 0 4 4 4 1 Las1-like BAF1_ABF1 PF04684.8 CDI78652.1 - 0.018 13.8 35.2 0.056 12.2 13.2 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Neur_chan_memb PF02932.11 CDI78652.1 - 0.019 14.8 26.8 0.051 13.4 6.0 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region OmpH PF03938.9 CDI78652.1 - 0.046 13.6 45.7 0.021 14.7 12.7 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) zf-DHHC PF01529.15 CDI78652.1 - 0.35 10.2 9.5 0.79 9.1 2.8 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase DDRGK PF09756.4 CDI78652.1 - 0.41 10.0 42.6 0.071 12.5 14.2 2.4 2 0 0 2 2 2 0 DDRGK domain Med15 PF09606.5 CDI78652.1 - 0.49 8.5 64.5 0.15 10.2 14.0 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF572 PF04502.8 CDI78652.1 - 1 8.5 42.5 2.6 7.1 14.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) DNA_pol_viral_N PF00242.12 CDI78652.1 - 1.2 8.1 48.8 0.37 9.7 13.2 2.1 2 0 0 2 2 2 0 DNA polymerase (viral) N-terminal domain DUF3337 PF11816.3 CDI78652.1 - 2.4 7.4 28.5 2.7 7.3 6.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3337) CDC45 PF02724.9 CDI78652.1 - 3.1 5.7 30.1 0.079 10.9 8.0 3.2 3 0 0 3 3 3 0 CDC45-like protein Cwf_Cwc_15 PF04889.7 CDI78652.1 - 4.5 6.9 48.3 0.049 13.3 16.3 2.5 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NARP1 PF12569.3 CDI78652.1 - 5.2 5.6 35.5 0.058 12.1 9.0 2.4 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 Peptidase_U57 PF05582.7 CDI78652.1 - 6.3 5.6 20.1 0.35 9.7 7.0 2.2 2 0 0 2 2 2 0 YabG peptidase U57 DUF3373 PF11853.3 CDI78652.1 - 6.7 5.1 14.0 6 5.2 4.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3373) Exonuc_VII_L PF02601.10 CDI78652.1 - 7.9 5.5 23.3 0.84 8.7 6.7 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Na_trans_assoc PF06512.8 CDI78652.1 - 9.8 6.0 33.5 1.3 8.9 8.9 2.4 2 0 0 2 2 2 0 Sodium ion transport-associated Herpes_UL87 PF03043.9 CDI78654.1 - 0.29 9.4 22.7 1.9e+02 0.1 15.8 2.5 1 1 0 1 1 1 0 Herpesvirus UL87 family E1-E2_ATPase PF00122.15 CDI78655.1 - 9.6e-15 54.2 0.0 2.1e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase PF00702.21 CDI78655.1 - 6.4e-12 46.3 14.3 1.5e-07 32.0 3.4 5.1 4 2 1 5 5 5 3 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDI78655.1 - 1.7e-10 41.3 0.0 0.00034 20.8 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDI78655.1 - 5.1e-06 26.3 0.3 3.9e-05 23.5 0.1 2.6 2 1 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CDI78655.1 - 0.023 14.2 0.1 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1700 PF08006.6 CDI78655.1 - 0.6 9.3 0.3 1.8 7.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) MFS_1 PF07690.11 CDI78656.1 - 2e-13 49.7 31.1 1.9e-09 36.7 7.0 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.2 CDI78656.1 - 0.0039 16.9 0.1 1.5 8.7 0.0 3.7 3 0 0 3 3 3 1 MFS_1 like family Sugar_tr PF00083.19 CDI78656.1 - 0.019 13.5 16.2 0.061 11.9 0.0 3.4 2 2 2 4 4 4 0 Sugar (and other) transporter Methyltransf_8 PF05148.10 CDI78658.1 - 4.7e-57 193.1 0.0 7.9e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 CDI78658.1 - 1e-05 25.9 0.2 6.4e-05 23.3 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Sas10 PF09368.5 CDI78661.1 - 8.1e-22 77.1 9.5 8.1e-22 77.1 6.6 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 CDI78661.1 - 1.3e-19 70.1 1.9 7.3e-19 67.7 1.3 2.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family AP_endonuc_2 PF01261.19 CDI78661.1 - 0.015 14.5 0.5 0.039 13.2 0.3 1.6 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel TRCF PF03461.10 CDI78661.1 - 0.017 15.1 0.3 0.1 12.5 0.0 2.4 2 0 0 2 2 2 0 TRCF domain RRM_1 PF00076.17 CDI78664.1 - 8.4e-16 57.3 0.0 1.5e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI78664.1 - 1.3e-13 50.7 0.0 4.4e-13 48.9 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI78664.1 - 2.6e-07 30.3 0.0 4.3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) THRAP3_BCLAF1 PF15440.1 CDI78664.1 - 0.61 8.6 11.4 0.74 8.4 7.9 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family PRP38_assoc PF12871.2 CDI78664.1 - 1 9.9 23.9 1.8 9.1 16.6 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Methyltransf_28 PF02636.12 CDI78670.1 - 0.00071 19.0 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RNase_PH PF01138.16 CDI78680.1 - 8.4e-05 22.8 3.8 0.00084 19.6 2.6 2.4 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 Rotamase_2 PF13145.1 CDI78680.1 - 0.092 13.3 1.0 0.56 10.8 0.4 2.3 3 0 0 3 3 3 0 PPIC-type PPIASE domain DUF3446 PF11928.3 CDI78680.1 - 5.4 7.2 44.9 0.99 9.6 6.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) DUF4094 PF13334.1 CDI78681.1 - 0.0027 18.0 0.2 0.0027 18.0 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4094) SYS1 PF09801.4 CDI78681.1 - 0.052 13.5 2.7 0.055 13.4 0.1 2.1 2 1 0 2 2 2 0 Integral membrane protein S linking to the trans Golgi network Methyltransf_31 PF13847.1 CDI78682.1 - 5.3e-08 32.5 1.4 2.3e-05 24.0 0.0 3.2 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_26 PF13659.1 CDI78682.1 - 2.6e-07 30.6 4.7 7.1e-07 29.2 0.0 3.7 3 2 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI78682.1 - 1.6e-05 25.4 0.0 0.019 15.5 0.0 3.3 2 0 0 2 2 2 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 CDI78682.1 - 0.00015 20.6 2.8 0.065 11.9 0.0 3.8 4 1 0 4 4 4 2 tRNA (Uracil-5-)-methyltransferase MTS PF05175.9 CDI78682.1 - 0.0008 18.8 2.1 0.045 13.1 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CDI78682.1 - 0.019 15.3 0.2 0.31 11.4 0.2 2.8 1 1 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 CDI78682.1 - 0.03 13.9 0.0 0.089 12.3 0.0 1.7 2 0 0 2 2 2 0 Met-10+ like-protein Methyltransf_23 PF13489.1 CDI78682.1 - 0.2 11.3 3.8 1.7 8.3 0.0 3.5 4 0 0 4 4 4 0 Methyltransferase domain PCMT PF01135.14 CDI78682.1 - 0.35 10.3 8.5 0.4 10.1 0.0 3.3 3 0 0 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Spt20 PF12090.3 CDI78682.1 - 3.1 7.1 35.7 0.035 13.4 1.0 5.2 5 0 0 5 5 5 0 Spt20 family DNA_pol_A PF00476.15 CDI78683.1 - 3.3e-47 160.9 4.8 9.3e-37 126.5 0.1 3.8 4 1 0 4 4 4 2 DNA polymerase family A Toprim_4 PF13662.1 CDI78683.1 - 4.2e-08 33.0 0.0 2.5e-07 30.6 0.0 2.5 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.1 CDI78683.1 - 3.3e-07 30.5 1.0 9.8e-07 29.0 0.0 2.5 2 1 0 2 2 2 1 Toprim-like DNA_pol_A_exo1 PF01612.15 CDI78683.1 - 3.9e-06 26.4 0.0 9.1e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease zf-CHC2 PF01807.15 CDI78683.1 - 0.0067 15.9 0.7 0.02 14.4 0.5 1.7 1 0 0 1 1 1 1 CHC2 zinc finger OmpH PF03938.9 CDI78683.1 - 3 7.7 0.0 3 7.7 0.0 8.4 6 4 0 6 6 6 0 Outer membrane protein (OmpH-like) PQ-loop PF04193.9 CDI78687.1 - 2.2e-05 23.9 0.3 5.1e-05 22.7 0.2 1.7 1 0 0 1 1 1 1 PQ loop repeat SLD3 PF08639.5 CDI78687.1 - 0.0038 15.9 0.4 0.0053 15.4 0.3 1.1 1 0 0 1 1 1 1 DNA replication regulator SLD3 ATP_transf PF09830.4 CDI78687.1 - 0.13 12.0 0.0 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 ATP adenylyltransferase Pex14_N PF04695.8 CDI78687.1 - 1.2 9.2 5.0 0.12 12.4 0.3 1.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPX PF03105.14 CDI78688.1 - 1.4 8.5 31.3 2 8.0 15.8 2.8 2 1 0 2 2 2 0 SPX domain Actin PF00022.14 CDI78689.1 - 3e-14 52.2 0.1 3.6e-13 48.6 0.1 2.6 1 1 0 1 1 1 1 Actin SR-25 PF10500.4 CDI78689.1 - 0.0094 15.4 13.3 0.0094 15.4 9.2 5.0 3 2 3 6 6 6 1 Nuclear RNA-splicing-associated protein BRF1 PF07741.8 CDI78689.1 - 1.3 9.2 13.3 3.6 7.8 2.2 3.4 3 0 0 3 3 3 0 Brf1-like TBP-binding domain RRF PF01765.14 CDI78690.1 - 4.3e-10 39.2 0.8 1.1e-05 24.9 0.2 4.8 3 2 1 4 4 4 2 Ribosome recycling factor BRCA2 PF00634.13 CDI78691.1 - 4e-35 118.6 0.2 0.00012 21.2 0.0 6.4 6 0 0 6 6 6 6 BRCA2 repeat BRCA-2_OB1 PF09103.5 CDI78691.1 - 3.2e-06 26.8 0.0 7.4e-05 22.4 0.0 2.5 1 1 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Hom_end_hint PF05203.11 CDI78691.1 - 0.0034 17.1 0.1 0.0034 17.1 0.1 5.9 4 1 1 5 5 5 1 Hom_end-associated Hint Ribosomal_60s PF00428.14 CDI78693.1 - 0.0099 16.2 2.1 0.0099 16.2 1.4 7.5 5 1 1 6 6 6 3 60s Acidic ribosomal protein FLO_LFY PF01698.11 CDI78693.1 - 0.061 12.1 3.3 0.14 10.9 2.3 1.5 1 0 0 1 1 1 0 Floricaula / Leafy protein TRAP_alpha PF03896.11 CDI78693.1 - 0.35 9.8 5.7 0.62 9.0 3.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Spore_coat_CotO PF14153.1 CDI78693.1 - 0.66 9.3 9.3 0.073 12.5 3.2 1.8 2 0 0 2 2 2 0 Spore coat protein CotO BUD22 PF09073.5 CDI78693.1 - 2.9 6.8 19.0 0.69 8.9 7.0 2.4 2 0 0 2 2 2 0 BUD22 PBP1_TM PF14812.1 CDI78693.1 - 7.8 6.8 7.4 24 5.3 5.1 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Macoilin PF09726.4 CDI78694.1 - 0.0066 14.8 6.7 0.012 13.9 4.6 1.5 1 0 0 1 1 1 1 Transmembrane protein Presenilin PF01080.12 CDI78694.1 - 0.37 9.5 2.9 0.62 8.8 2.0 1.3 1 0 0 1 1 1 0 Presenilin DUF2217 PF10265.4 CDI78694.1 - 0.77 8.4 8.9 1.3 7.7 6.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) AF-4 PF05110.8 CDI78694.1 - 1.4 6.6 25.2 2.3 5.9 17.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DNA_pol_viral_N PF00242.12 CDI78694.1 - 7.4 5.4 11.1 13 4.7 7.7 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF2611 PF11022.3 CDI78695.1 - 0.05 13.6 0.1 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2611) Nop53 PF07767.6 CDI78695.1 - 0.35 9.8 6.1 0.47 9.3 4.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RRP7 PF12923.2 CDI78695.1 - 0.35 10.8 4.5 9.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) DUF615 PF04751.9 CDI78697.1 - 0.014 15.0 2.3 0.021 14.4 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF615) BAR PF03114.13 CDI78697.1 - 0.12 11.8 1.0 0.18 11.2 0.7 1.2 1 0 0 1 1 1 0 BAR domain DUF761 PF05553.6 CDI78697.1 - 2.9 7.3 5.8 9.6 5.6 0.3 2.4 2 0 0 2 2 2 0 Cotton fibre expressed protein TroA PF01297.12 CDI78698.1 - 0.05 12.8 0.2 0.078 12.2 0.1 1.2 1 0 0 1 1 1 0 Periplasmic solute binding protein family CTK3 PF12243.3 CDI78698.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 UPF0149 PF03695.8 CDI78698.1 - 0.17 11.7 3.8 0.27 11.0 1.6 2.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0149) DUF761 PF05553.6 CDI78698.1 - 4.4 6.7 5.7 0.38 10.1 0.4 1.8 2 0 0 2 2 2 0 Cotton fibre expressed protein DDRGK PF09756.4 CDI78700.1 - 0.0061 15.9 7.9 0.0061 15.9 5.5 5.2 3 1 2 5 5 5 1 DDRGK domain UPF0564 PF10595.4 CDI78702.1 - 1.2e-07 31.0 12.9 1.2e-07 31.0 9.0 5.5 5 0 0 5 5 5 1 Uncharacterised protein family UPF0564 PilN PF05137.8 CDI78703.1 - 0.025 14.4 0.3 0.12 12.2 0.2 2.2 1 1 0 1 1 1 0 Fimbrial assembly protein (PilN) APC_CDC26 PF10471.4 CDI78704.1 - 1.4 9.7 5.9 2.3 9.0 4.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 Activator_LAG-3 PF11498.3 CDI78704.1 - 2.8 6.5 11.6 3.6 6.2 8.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SR-25 PF10500.4 CDI78704.1 - 4.5 6.6 11.4 6.1 6.2 7.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_UL87 PF03043.9 CDI78705.1 - 0.001 17.5 0.0 0.63 8.3 0.0 2.6 2 1 0 2 2 2 2 Herpesvirus UL87 family Sec3_C PF09763.4 CDI78707.1 - 0.048 11.8 1.6 0.044 11.9 1.1 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Corona_nucleoca PF00937.13 CDI78707.1 - 0.59 9.0 13.4 0.84 8.5 9.3 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF572 PF04502.8 CDI78707.1 - 0.79 8.8 5.7 1.3 8.1 4.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4614 PF15391.1 CDI78707.1 - 0.8 9.4 18.3 0.066 12.9 8.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Apt1 PF10351.4 CDI78707.1 - 0.9 8.3 11.8 1.2 7.8 8.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Claudin_2 PF13903.1 CDI78707.1 - 9 5.9 12.8 7.5 6.2 8.0 1.6 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Fmp27_WPPW PF10359.4 CDI78708.1 - 3.4 5.9 13.6 6.1 5.1 9.4 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SAGA-Tad1 PF12767.2 CDI78709.1 - 0.067 12.8 9.4 0.082 12.5 6.5 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit OspD PF03207.8 CDI78709.1 - 0.98 8.5 4.6 0.26 10.4 0.5 1.7 1 1 1 2 2 2 0 Borrelia outer surface protein D (OspD) Peptidase_S64 PF08192.6 CDI78709.1 - 2.2 6.4 11.5 2.9 6.1 7.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 PNP_UDP_1 PF01048.15 CDI78710.1 - 1.2e-25 89.9 0.1 1.3e-25 89.7 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily TF_AP-2 PF03299.9 CDI78710.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Transcription factor AP-2 Aldedh PF00171.17 CDI78711.1 - 5.5e-136 453.5 3.5 2.9e-122 408.3 1.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family LuxC PF05893.9 CDI78711.1 - 0.00013 20.8 0.9 0.00032 19.5 0.6 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Peptidase_S58 PF03576.9 CDI78711.1 - 0.026 13.6 0.0 0.05 12.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S58 CLAG PF03805.8 CDI78712.1 - 0.0012 16.2 0.8 0.21 8.9 0.0 2.3 2 0 0 2 2 2 2 Cytoadherence-linked asexual protein Utp14 PF04615.8 CDI78713.1 - 2.3 6.2 47.1 3 5.8 32.7 1.1 1 0 0 1 1 1 0 Utp14 protein Hid1 PF12722.2 CDI78713.1 - 9.2 3.7 24.4 12 3.4 16.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HA2 PF04408.18 CDI78714.1 - 2.7e-18 65.8 0.5 2.7e-18 65.8 0.3 5.6 6 0 0 6 6 6 1 Helicase associated domain (HA2) DPPIV_N PF00930.16 CDI78714.1 - 3.8e-16 58.6 1.5 9.7e-12 44.1 0.0 3.2 3 0 0 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 CDI78714.1 - 1.6e-14 53.6 0.1 1.6e-14 53.6 0.1 3.0 2 1 0 2 2 2 1 Prolyl oligopeptidase family Helicase_C PF00271.26 CDI78714.1 - 6.1e-10 38.8 0.0 2.3e-09 36.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Rep_fac_C PF08542.6 CDI78715.1 - 3.4e-08 33.3 0.0 5.9e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.10 CDI78715.1 - 0.00065 18.5 0.2 0.092 11.4 0.0 2.4 1 1 2 3 3 3 2 Rad17 cell cycle checkpoint protein DNA_pol3_delta2 PF13177.1 CDI78715.1 - 0.0012 18.4 0.7 0.0023 17.6 0.5 1.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.8 CDI78715.1 - 0.029 13.8 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Macoilin PF09726.4 CDI78715.1 - 1.8 6.7 7.4 2.5 6.3 5.1 1.1 1 0 0 1 1 1 0 Transmembrane protein RAP1 PF07218.6 CDI78715.1 - 2 6.4 5.8 2.4 6.1 4.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Chorein_N PF12624.2 CDI78716.1 - 1.1e-05 24.8 2.6 4.1e-05 23.0 0.0 2.5 2 0 0 2 2 2 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF1162 PF06650.7 CDI78716.1 - 7.4e-05 22.0 0.0 0.00031 20.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1162) DUF2203 PF09969.4 CDI78716.1 - 1.1 9.5 1.8 4.6 7.4 1.2 2.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Choline_transpo PF04515.7 CDI78716.1 - 9.1 4.9 0.0 16 4.0 0.0 1.3 1 0 0 1 1 1 0 Plasma-membrane choline transporter Myb_DNA-binding PF00249.26 CDI78717.1 - 7.7e-17 61.0 8.1 5.9e-12 45.4 0.2 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDI78717.1 - 1.7e-14 53.6 7.8 8.5e-14 51.4 1.8 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_Cef PF11831.3 CDI78718.1 - 9.6e-22 77.3 3.5 9.6e-22 77.3 2.4 2.4 2 0 0 2 2 2 1 pre-mRNA splicing factor component DNA_primase_S PF01896.14 CDI78718.1 - 0.14 11.9 0.1 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase small subunit DUF2532 PF10811.3 CDI78718.1 - 1.4 8.6 4.2 0.25 11.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2532) DUF4230 PF14014.1 CDI78718.1 - 4.4 7.1 9.3 5.2 6.9 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4230) Kazal_2 PF07648.10 CDI78719.1 - 7.1e-28 96.2 35.7 3.4e-08 33.3 0.8 4.4 3 1 1 4 4 4 4 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.16 CDI78719.1 - 8.2e-21 73.7 42.7 3.2e-07 30.2 0.7 4.4 2 1 2 4 4 4 4 Kazal-type serine protease inhibitor domain PET PF06297.9 CDI78719.1 - 0.033 13.8 0.1 14 5.4 0.0 3.6 4 0 0 4 4 4 0 PET Domain Gamma-thionin PF00304.15 CDI78719.1 - 2.1 8.4 44.5 1 9.4 0.7 5.0 3 2 2 5 5 5 0 Gamma-thionin family Got1 PF04178.7 CDI78720.1 - 3.6e-30 104.4 19.7 5.2e-30 103.9 13.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2076 PF09849.4 CDI78720.1 - 0.29 11.1 1.0 0.49 10.4 0.7 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF1469 PF07332.6 CDI78720.1 - 9.6 5.9 13.5 0.31 10.7 4.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) Lectin_leg-like PF03388.8 CDI78721.1 - 1.8e-12 46.8 0.3 6.5e-12 45.0 0.2 1.8 1 1 0 1 1 1 1 Legume-like lectin family Asn_synthase PF00733.16 CDI78722.1 - 1.2e-25 90.4 0.5 1.2e-16 61.0 0.0 2.4 2 0 0 2 2 2 2 Asparagine synthase NAD_synthase PF02540.12 CDI78722.1 - 0.45 9.3 0.2 0.7 8.7 0.2 1.2 1 0 0 1 1 1 0 NAD synthase AAA_12 PF13087.1 CDI78725.1 - 8.4e-37 126.4 0.0 1.6e-28 99.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.1 CDI78725.1 - 3.2e-08 33.4 0.0 0.001 18.7 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.1 CDI78725.1 - 7.1e-07 28.9 0.3 2.4e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDI78725.1 - 5.6e-06 26.0 3.2 1.8e-05 24.3 0.1 3.5 3 0 0 3 3 3 1 Part of AAA domain Viral_helicase1 PF01443.13 CDI78725.1 - 0.00058 19.4 0.0 1 8.8 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA PF00004.24 CDI78725.1 - 0.23 11.6 0.0 0.53 10.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 CDI78726.1 - 3.7e-51 173.4 0.0 1e-49 168.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 CDI78726.1 - 6.5e-20 70.8 1.0 2.7e-19 68.8 0.1 2.6 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 CDI78726.1 - 9.1e-20 71.2 0.0 5.5e-10 39.5 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Clp_N PF02861.15 CDI78726.1 - 1.7e-15 56.6 6.3 2.6e-09 36.8 0.1 3.7 4 0 0 4 4 2 2 Clp amino terminal domain AAA_5 PF07728.9 CDI78726.1 - 9.8e-12 44.7 0.1 2.6e-10 40.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 CDI78726.1 - 8.3e-07 28.6 0.0 7.5e-06 25.5 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.1 CDI78726.1 - 1.4e-06 28.4 13.2 0.014 15.3 0.0 6.3 4 3 1 6 6 6 2 AAA ATPase domain AAA_22 PF13401.1 CDI78726.1 - 3.2e-06 27.3 0.3 0.0012 19.0 0.0 3.8 2 1 1 3 3 3 1 AAA domain AAA_14 PF13173.1 CDI78726.1 - 4.5e-06 26.5 0.0 0.0068 16.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 CDI78726.1 - 8.8e-05 21.6 0.0 0.015 14.3 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 CDI78726.1 - 0.00037 19.6 0.3 0.0028 16.7 0.0 2.6 2 1 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 CDI78726.1 - 0.0012 19.6 3.6 0.0017 19.1 0.1 3.1 2 2 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 CDI78726.1 - 0.0013 18.5 3.0 0.28 10.8 0.0 3.5 4 1 0 4 4 3 1 Archaeal ATPase DNA_pol3_delta2 PF13177.1 CDI78726.1 - 0.0015 18.2 0.0 0.016 14.8 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_10 PF12846.2 CDI78726.1 - 0.0026 17.2 0.6 0.043 13.2 0.0 2.9 3 0 0 3 3 3 1 AAA-like domain AAA_18 PF13238.1 CDI78726.1 - 0.0034 17.6 0.4 0.024 14.9 0.0 2.6 2 1 1 3 3 3 1 AAA domain Sulfatase_C PF14707.1 CDI78726.1 - 0.004 17.4 0.1 0.0098 16.1 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase T2SE PF00437.15 CDI78726.1 - 0.0045 15.9 0.0 0.0099 14.8 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein IstB_IS21 PF01695.12 CDI78726.1 - 0.029 13.7 0.0 0.093 12.1 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.6 CDI78726.1 - 0.03 13.9 0.0 0.27 10.8 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 CDI78726.1 - 0.042 14.1 0.1 0.19 11.9 0.0 2.1 2 0 0 2 2 1 0 ABC transporter MobB PF03205.9 CDI78726.1 - 0.065 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 CDI78726.1 - 0.24 11.6 0.0 0.6 10.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF87 PF01935.12 CDI78726.1 - 0.38 10.5 2.7 1.1 8.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF87 Phage_GP20 PF06810.6 CDI78726.1 - 0.41 10.0 9.2 2.2 7.7 3.9 2.6 2 0 0 2 2 2 0 Phage minor structural protein GP20 Coatomer_WDAD PF04053.9 CDI78727.1 - 3.9e-77 259.9 0.0 9.2e-77 258.6 0.0 1.6 1 1 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 CDI78727.1 - 4e-57 188.1 10.6 3.4e-11 42.5 0.0 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat COPI_C PF06957.6 CDI78727.1 - 3.6e-44 150.9 0.0 5.9e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Nup160 PF11715.3 CDI78727.1 - 0.0034 15.6 10.2 0.2 9.7 0.2 3.7 1 1 2 4 4 4 2 Nucleoporin Nup120/160 TPR_2 PF07719.12 CDI78727.1 - 0.0085 15.9 2.9 3.8 7.6 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat Nucleoporin_N PF08801.6 CDI78727.1 - 0.019 13.7 0.1 0.58 8.8 0.0 2.7 2 1 1 3 3 3 0 Nup133 N terminal like Apc4_WD40 PF12894.2 CDI78727.1 - 0.022 14.2 0.0 3.2 7.3 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_14 PF13428.1 CDI78727.1 - 0.15 12.7 8.1 43 5.1 0.1 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ArsC PF03960.10 CDI78727.1 - 0.24 11.4 0.0 0.51 10.4 0.0 1.5 1 0 0 1 1 1 0 ArsC family TPR_16 PF13432.1 CDI78727.1 - 0.43 11.3 7.3 12 6.7 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2361 PF10153.4 CDI78728.1 - 0.34 11.1 21.8 0.067 13.3 10.6 2.6 2 1 1 3 3 3 0 Uncharacterised conserved protein (DUF2361) Maf PF02545.9 CDI78729.1 - 4.9e-19 68.2 0.1 6.1e-07 28.7 0.0 3.1 3 0 0 3 3 3 3 Maf-like protein Zn-ribbon_8 PF09723.5 CDI78729.1 - 0.17 11.8 3.4 0.4 10.6 2.4 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DSPc PF00782.15 CDI78730.1 - 1.6e-07 30.9 0.0 3.6e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDI78730.1 - 4.5e-05 22.9 0.0 0.0001 21.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Glyco_trans_4_4 PF13579.1 CDI78730.1 - 0.18 11.9 5.5 0.051 13.7 1.4 1.9 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain NOC3p PF07540.6 CDI78732.1 - 5.2e-07 29.8 2.6 0.00043 20.4 1.8 4.0 1 1 0 1 1 1 1 Nucleolar complex-associated protein TFIIF_alpha PF05793.7 CDI78732.1 - 1 7.6 31.3 1.9 6.7 10.1 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Arm PF00514.18 CDI78733.1 - 2.1e-10 40.0 44.0 1.6e-05 24.5 0.6 8.0 8 0 0 8 8 8 5 Armadillo/beta-catenin-like repeat PRKCSH-like PF12999.2 CDI78734.1 - 0.11 12.1 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Cyclin PF08613.6 CDI78735.1 - 1.8e-19 70.6 0.0 1.8e-19 70.6 0.0 6.4 6 2 0 6 6 6 1 Cyclin Cwf_Cwc_15 PF04889.7 CDI78735.1 - 0.0018 18.0 31.1 0.0018 18.0 21.5 7.4 5 3 2 7 7 7 1 Cwf15/Cwc15 cell cycle control protein Snf7 PF03357.16 CDI78737.1 - 6.7e-12 45.1 18.0 6.7e-12 45.1 12.5 2.8 2 1 1 3 3 3 1 Snf7 PAT1 PF09770.4 CDI78737.1 - 1.2 7.2 52.2 1.7 6.7 36.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ADK PF00406.17 CDI78738.1 - 1.9e-20 73.2 0.0 5e-20 71.9 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.1 CDI78738.1 - 0.0029 18.4 0.0 0.0063 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad9 PF04139.8 CDI78738.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Rad9 AAA_18 PF13238.1 CDI78738.1 - 0.29 11.4 2.5 0.43 10.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain Secretin_N_2 PF07655.8 CDI78738.1 - 0.84 10.0 16.5 1.2 9.5 3.2 2.9 2 0 0 2 2 2 0 Secretin N-terminal domain DUF755 PF05501.6 CDI78740.1 - 0.0045 17.0 27.6 0.0045 17.0 19.1 6.6 6 1 0 6 6 6 1 Domain of unknown function (DUF755) Eapp_C PF10238.4 CDI78741.1 - 2.9e-08 33.6 3.3 2.9e-08 33.6 2.3 3.2 2 1 0 3 3 3 1 E2F-associated phosphoprotein Yippee-Mis18 PF03226.9 CDI78741.1 - 0.0045 17.0 2.3 0.0045 17.0 1.6 2.5 1 1 1 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LUC7 PF03194.10 CDI78741.1 - 0.013 14.9 19.2 0.027 14.0 13.3 1.5 1 0 0 1 1 1 0 LUC7 N_terminus Mitofilin PF09731.4 CDI78741.1 - 6.1 5.3 45.3 9.3 4.7 31.4 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1510 PF07423.6 CDI78742.1 - 0.011 15.0 13.3 0.011 15.0 9.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) PIG-P PF08510.7 CDI78742.1 - 0.47 10.0 0.0 0.47 10.0 0.0 3.6 2 1 0 2 2 2 0 PIG-P CDC45 PF02724.9 CDI78742.1 - 3.7 5.4 53.2 0.015 13.3 17.2 2.4 2 0 0 2 2 2 0 CDC45-like protein Ycf1 PF05758.7 CDI78742.1 - 5.9 4.4 53.1 3.1 5.3 11.3 2.1 2 0 0 2 2 2 0 Ycf1 DEAD PF00270.24 CDI78743.1 - 6.7e-10 38.7 0.0 9.2e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pex14_N PF04695.8 CDI78744.1 - 0.4 10.7 5.5 0.75 9.8 3.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_60s PF00428.14 CDI78744.1 - 0.75 10.2 9.1 8.8 6.7 1.5 3.1 3 0 0 3 3 3 0 60s Acidic ribosomal protein MIP-T3 PF10243.4 CDI78745.1 - 0.059 11.8 50.8 0.091 11.2 35.2 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PAT1 PF09770.4 CDI78745.1 - 5.8 5.0 80.7 10 4.2 55.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PBP PF01161.15 CDI78746.1 - 0.00041 20.2 0.0 0.00062 19.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein HEAT PF02985.17 CDI78747.1 - 0.00089 19.1 16.9 0.041 13.9 0.0 6.9 6 0 0 6 6 6 3 HEAT repeat Vac14_Fab1_bd PF12755.2 CDI78747.1 - 0.1 12.9 0.0 3.5 8.0 0.0 2.5 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DTW PF03942.10 CDI78748.1 - 4.5e-14 52.1 12.3 3e-07 29.8 0.0 4.3 3 1 1 4 4 4 3 DTW domain PT-VENN PF04829.8 CDI78748.1 - 0.72 9.4 13.1 0.32 10.5 3.5 2.8 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif DDHD PF02862.12 CDI78748.1 - 7.4 6.2 9.3 6.4 6.4 0.5 2.2 2 0 0 2 2 2 0 DDHD domain DUF21 PF01595.15 CDI78749.1 - 0.0031 16.8 2.3 0.0038 16.5 0.5 1.8 2 0 0 2 2 2 1 Domain of unknown function DUF21 DUF2721 PF11026.3 CDI78749.1 - 0.023 14.3 0.8 0.046 13.3 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) UPF0258 PF06789.7 CDI78749.1 - 0.052 13.6 0.7 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) TcpE PF12648.2 CDI78749.1 - 0.093 12.8 0.6 0.2 11.8 0.4 1.5 1 0 0 1 1 1 0 TcpE family DUF2207 PF09972.4 CDI78749.1 - 0.1 11.1 0.5 0.14 10.6 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SieB PF14163.1 CDI78749.1 - 0.23 11.0 3.4 0.44 10.1 2.4 1.4 1 0 0 1 1 1 0 Superinfection exclusion protein B Herpes_US9 PF06072.6 CDI78749.1 - 0.3 10.9 5.3 0.11 12.2 0.7 2.4 2 1 1 3 3 3 0 Alphaherpesvirus tegument protein US9 UPF0016 PF01169.14 CDI78749.1 - 0.43 10.7 5.7 1.8 8.7 4.1 2.0 1 1 0 1 1 1 0 Uncharacterized protein family UPF0016 DUF4366 PF14283.1 CDI78754.1 - 0.071 12.5 3.8 0.45 9.9 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Med15 PF09606.5 CDI78754.1 - 0.59 8.2 25.0 0.5 8.5 11.2 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI78754.1 - 0.65 9.6 9.7 0.75 9.4 2.0 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF912 PF06024.7 CDI78754.1 - 0.85 9.7 4.3 13 5.8 0.2 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) RAB3GAP2_N PF14655.1 CDI78754.1 - 3.5 6.5 12.6 2.4 7.0 3.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4557 PF15101.1 CDI78754.1 - 9 6.0 17.8 8.3 6.1 5.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) RRM_1 PF00076.17 CDI78755.1 - 1.7e-08 33.9 0.0 3.6e-07 29.7 0.0 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 CDI78755.1 - 2.1e-07 30.5 0.6 0.15 11.9 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat RRM_5 PF13893.1 CDI78755.1 - 3.3e-07 30.0 0.0 7.4e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI78755.1 - 9.6e-06 25.4 0.0 0.0001 22.2 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) G-patch PF01585.18 CDI78756.1 - 0.0025 17.5 1.5 0.0063 16.2 1.1 1.7 1 0 0 1 1 1 1 G-patch domain zf-CCCH PF00642.19 CDI78756.1 - 0.072 12.7 0.1 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Methyltransf_18 PF12847.2 CDI78757.1 - 5.7e-06 26.8 0.0 1.8e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CDI78757.1 - 3.1e-05 23.2 0.0 6.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.10 CDI78757.1 - 3.6e-05 23.2 0.2 7.2e-05 22.2 0.2 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.9 CDI78757.1 - 7e-05 22.2 0.0 0.00014 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.11 CDI78757.1 - 9.9e-05 21.4 0.0 0.00022 20.3 0.0 1.5 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase Methyltransf_31 PF13847.1 CDI78757.1 - 0.01 15.4 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI78757.1 - 0.022 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.6 CDI78757.1 - 0.071 11.7 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Met_10 PF02475.11 CDI78757.1 - 0.079 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DOT1 PF08123.8 CDI78757.1 - 0.12 11.6 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 AAA_12 PF13087.1 CDI78758.1 - 5.8e-40 136.8 0.0 5.8e-40 136.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain Ribosomal_S13_N PF08069.7 CDI78758.1 - 0.079 12.7 0.1 0.37 10.6 0.0 2.1 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain Chorion_2 PF03964.10 CDI78758.1 - 0.35 11.4 4.6 2.7 8.5 0.5 2.4 2 0 0 2 2 2 0 Chorion family 2 RR_TM4-6 PF06459.7 CDI78758.1 - 8.8 6.1 9.2 1.5 8.6 3.6 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF1777 PF08648.7 CDI78759.1 - 3.1 7.4 26.4 3.6 7.2 18.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Membralin PF09746.4 CDI78759.1 - 5.9 5.8 19.6 6.7 5.6 13.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein Herpes_env PF01673.13 CDI78759.1 - 9.1 4.7 22.9 11 4.4 15.8 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein CAF-1_p150 PF11600.3 CDI78760.1 - 0.15 11.3 33.7 0.18 11.1 23.4 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SprA-related PF12118.3 CDI78760.1 - 1.4 8.1 55.2 1.8 7.8 38.2 1.0 1 0 0 1 1 1 0 SprA-related family Ycf1 PF05758.7 CDI78760.1 - 1.5 6.4 25.8 1.7 6.2 17.9 1.0 1 0 0 1 1 1 0 Ycf1 DUF4603 PF15376.1 CDI78760.1 - 1.7 5.6 19.2 2 5.5 13.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF1510 PF07423.6 CDI78760.1 - 3.5 6.9 27.8 6.1 6.1 19.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TP53IP5 PF15331.1 CDI78760.1 - 4.1 7.2 24.0 4.8 7.0 16.7 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 SR-25 PF10500.4 CDI78760.1 - 4.4 6.7 40.5 2.3e+02 1.0 28.0 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Parvo_coat PF00740.13 CDI78760.1 - 6.1 5.6 32.8 6.9 5.4 22.7 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Presenilin PF01080.12 CDI78760.1 - 9.6 4.9 19.7 11 4.7 13.6 1.0 1 0 0 1 1 1 0 Presenilin UPF1_Zn_bind PF09416.5 CDI78761.1 - 7.4e-41 139.2 2.4 7.4e-41 139.2 1.7 2.5 2 1 1 3 3 3 1 RNA helicase (UPF2 interacting domain) CAF-1_p150 PF11600.3 CDI78761.1 - 0.0069 15.7 35.2 0.0069 15.7 24.4 2.2 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal SR-25 PF10500.4 CDI78761.1 - 0.38 10.1 61.2 0.3 10.5 4.3 3.4 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein SOBP PF15279.1 CDI78761.1 - 3.7 7.8 27.2 1.4 9.1 16.2 1.9 2 0 0 2 2 2 0 Sine oculis-binding protein Vfa1 PF08432.5 CDI78762.1 - 0.19 11.7 34.9 0.22 11.5 24.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CAF-1_p150 PF11600.3 CDI78762.1 - 0.23 10.8 48.8 0.29 10.4 33.8 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal FLO_LFY PF01698.11 CDI78762.1 - 0.48 9.2 32.6 0.58 8.9 22.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Utp14 PF04615.8 CDI78762.1 - 0.67 8.0 40.4 0.77 7.8 28.0 1.0 1 0 0 1 1 1 0 Utp14 protein DUF1510 PF07423.6 CDI78762.1 - 1.2 8.4 41.3 1.5 8.1 28.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Caldesmon PF02029.10 CDI78762.1 - 1.4 7.2 35.3 1.7 6.9 24.5 1.0 1 0 0 1 1 1 0 Caldesmon Daxx PF03344.10 CDI78762.1 - 1.8 6.9 33.8 2 6.8 23.4 1.0 1 0 0 1 1 1 0 Daxx Family POP1 PF06978.6 CDI78762.1 - 1.9 8.1 29.5 2.7 7.6 20.5 1.2 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 MIP-T3 PF10243.4 CDI78762.1 - 3.4 6.0 50.5 4.1 5.7 35.0 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 FAM60A PF15396.1 CDI78762.1 - 3.9 7.1 30.3 4.7 6.8 21.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Asp-B-Hydro_N PF05279.6 CDI78762.1 - 4.8 6.9 33.2 5.6 6.7 23.0 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF2146 PF10220.4 CDI78762.1 - 4.8 5.0 28.0 5.8 4.7 19.4 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Ycf1 PF05758.7 CDI78762.1 - 5.1 4.6 37.5 5.9 4.4 26.0 1.0 1 0 0 1 1 1 0 Ycf1 DUF4045 PF13254.1 CDI78762.1 - 5.8 6.0 31.6 6.8 5.8 21.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Rtf2 PF04641.7 CDI78762.1 - 6 5.9 34.4 8 5.5 23.9 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger CDC45 PF02724.9 CDI78762.1 - 7.8 4.3 38.6 9.1 4.1 26.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.1 CDI78762.1 - 8.7 4.7 32.0 10 4.4 22.2 1.1 1 0 0 1 1 1 0 Raftlin TSP_1 PF00090.14 CDI78763.1 - 1.3e-70 233.3 204.5 9.9e-13 47.9 2.1 17.9 18 1 0 18 18 18 13 Thrombospondin type 1 domain Notch PF00066.12 CDI78763.1 - 1.9e-11 44.0 39.0 9e-10 38.6 9.5 6.9 5 0 0 5 5 5 2 LNR domain Arf PF00025.16 CDI78764.1 - 8.3e-19 67.4 0.0 6.4e-18 64.5 0.0 2.3 1 1 1 2 2 2 1 ADP-ribosylation factor family Miro PF08477.8 CDI78764.1 - 0.0007 20.0 0.0 0.002 18.6 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 CDI78764.1 - 0.034 13.3 0.0 0.18 11.0 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Ras PF00071.17 CDI78764.1 - 0.037 13.4 0.0 0.17 11.2 0.0 1.9 1 1 0 1 1 1 0 Ras family MMR_HSR1 PF01926.18 CDI78764.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.1 CDI78764.1 - 0.49 10.2 0.1 0.49 10.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain Nop14 PF04147.7 CDI78765.1 - 1.3 6.8 27.0 1.3 6.8 18.7 1.0 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.6 CDI78765.1 - 1.5 6.5 16.9 1.7 6.4 11.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FCP1_C PF09309.5 CDI78765.1 - 1.6 7.9 15.0 1.7 7.8 10.4 1.1 1 0 0 1 1 1 0 FCP1, C-terminal G0-G1_switch_2 PF15103.1 CDI78765.1 - 3.5 7.8 5.8 4 7.7 4.0 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 Trypan_PARP PF05887.6 CDI78765.1 - 4.1 7.2 15.6 4.4 7.1 10.8 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Merozoite_SPAM PF07133.6 CDI78765.1 - 5.2 6.9 22.1 5.8 6.7 15.3 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF2457 PF10446.4 CDI78765.1 - 5.8 5.5 26.6 6.9 5.2 18.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.7 CDI78765.1 - 5.9 6.0 27.5 6.6 5.9 19.1 1.0 1 0 0 1 1 1 0 SDA1 GOLD_2 PF13897.1 CDI78765.1 - 6.6 6.9 7.4 7.6 6.7 5.1 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Pox_RNA_Pol_19 PF05320.7 CDI78765.1 - 7.4 6.2 14.7 9.1 5.9 10.2 1.1 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Prothymosin PF03247.9 CDI78765.1 - 7.5 6.7 29.9 12 6.0 20.7 1.4 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF2890 PF11081.3 CDI78765.1 - 7.8 6.5 20.9 8.1 6.4 14.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) ERF PF04404.7 CDI78765.1 - 7.9 5.9 10.7 10 5.6 7.4 1.2 1 0 0 1 1 1 0 ERF superfamily DUF3381 PF11861.3 CDI78765.1 - 8.7 5.8 17.4 9.7 5.6 12.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) CDC45 PF02724.9 CDI78765.1 - 9.7 4.0 20.3 9.5 4.1 14.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3537 PF12056.3 CDI78765.1 - 9.8 4.7 7.3 11 4.5 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Utp14 PF04615.8 CDI78766.1 - 6.9 4.6 72.2 8.5 4.4 50.0 1.0 1 0 0 1 1 1 0 Utp14 protein RNA_pol_Rpb1_5 PF04998.12 CDI78768.1 - 7.6e-05 22.1 0.0 0.0016 17.7 0.0 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Spore_coat_CotO PF14153.1 CDI78768.1 - 0.012 15.0 1.7 0.012 15.0 1.2 2.3 2 0 0 2 2 2 0 Spore coat protein CotO SAPS PF04499.10 CDI78768.1 - 0.72 8.4 24.6 6.5 5.2 0.0 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein SAGA-Tad1 PF12767.2 CDI78768.1 - 0.87 9.1 42.0 1.3 8.5 18.7 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Band_3_cyto PF07565.8 CDI78768.1 - 1.8 7.9 33.9 0.33 10.4 0.5 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4045 PF13254.1 CDI78768.1 - 2.4 7.3 28.5 4.2 6.5 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Ycf1 PF05758.7 CDI78768.1 - 7.6 4.1 33.3 0.0071 14.1 10.2 2.0 2 0 0 2 2 2 0 Ycf1 tRNA-synt_2d PF01409.15 CDI78769.1 - 2.1e-22 79.5 0.0 2.8e-15 56.2 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) SAPS PF04499.10 CDI78769.1 - 5e-07 28.7 12.9 6.5e-06 25.0 0.5 2.1 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein Caldesmon PF02029.10 CDI78769.1 - 3.3e-06 25.8 13.5 7.9e-06 24.5 0.6 2.2 2 0 0 2 2 2 2 Caldesmon Spore_coat_CotO PF14153.1 CDI78769.1 - 0.00038 19.9 20.7 0.00038 19.9 14.4 2.5 2 1 0 2 2 1 1 Spore coat protein CotO HemX PF04375.9 CDI78769.1 - 0.00064 18.4 26.2 0.00064 18.4 18.2 4.3 4 1 1 5 5 4 1 HemX CDC45 PF02724.9 CDI78769.1 - 0.0081 14.2 25.0 0.0087 14.1 9.0 2.2 2 0 0 2 2 2 2 CDC45-like protein Mem_trans PF03547.13 CDI78769.1 - 0.019 13.2 0.0 0.019 13.2 0.0 2.6 3 0 0 3 3 3 0 Membrane transport protein Hom_end_hint PF05203.11 CDI78769.1 - 0.019 14.6 0.4 0.019 14.6 0.3 2.5 2 0 0 2 2 2 0 Hom_end-associated Hint LMBR1 PF04791.11 CDI78769.1 - 0.061 11.9 6.4 0.2 10.2 0.1 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF572 PF04502.8 CDI78769.1 - 0.58 9.3 39.1 0.14 11.3 7.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) TT_ORF1 PF02956.9 CDI78769.1 - 1.5 7.1 28.1 1.9 6.8 8.1 2.1 2 0 0 2 2 2 0 TT viral orf 1 CDK2AP PF09806.4 CDI78771.1 - 0.00017 21.9 7.4 0.00017 21.9 5.1 3.2 2 1 0 2 2 2 1 Cyclin-dependent kinase 2-associated protein SbcCD_C PF13558.1 CDI78771.1 - 4.9 7.1 8.0 0.34 10.8 0.5 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit FabA PF07977.8 CDI78772.1 - 6.9e-15 54.7 0.0 7.8e-15 54.5 0.0 1.0 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydrat_N PF13452.1 CDI78772.1 - 0.018 14.8 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase Cytochrom_C_asm PF01578.15 CDI78773.1 - 0.96 8.9 6.3 0.29 10.6 2.0 1.8 2 0 0 2 2 2 0 Cytochrome C assembly protein Ribosomal_60s PF00428.14 CDI78773.1 - 4.1 7.8 8.8 0.67 10.3 1.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DEAD PF00270.24 CDI78774.1 - 3.3e-16 59.2 0.6 1.5e-10 40.8 0.0 3.0 2 1 1 3 3 3 2 DEAD/DEAH box helicase Sec63 PF02889.11 CDI78774.1 - 2.8e-09 36.6 0.2 6.3e-09 35.4 0.1 1.6 2 0 0 2 2 2 1 Sec63 Brl domain Helicase_C PF00271.26 CDI78774.1 - 1.1e-07 31.6 0.0 1.1e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI78774.1 - 0.00016 21.5 0.1 0.0013 18.6 0.0 2.4 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CDI78774.1 - 0.0013 18.8 0.0 0.084 13.0 0.0 3.0 1 1 0 1 1 1 1 AAA domain Pkinase PF00069.20 CDI78775.1 - 8.8e-49 165.9 0.0 1.1e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78775.1 - 3.3e-19 68.9 0.0 2.1e-18 66.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CDI78775.1 - 0.098 11.7 0.1 0.19 10.7 0.0 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Daxx PF03344.10 CDI78775.1 - 4.9 5.5 9.2 6.3 5.1 6.4 1.1 1 0 0 1 1 1 0 Daxx Family Pkinase PF00069.20 CDI78776.1 - 0.0011 18.2 0.0 0.0013 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF1180 PF06679.7 CDI78776.1 - 0.78 9.6 3.2 1.1 9.0 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2973 PF11189.3 CDI78778.1 - 0.16 11.7 0.1 0.85 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) DUF1675 PF07897.6 CDI78778.1 - 2 8.2 11.8 0.11 12.2 4.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1675) WBP-1 PF11669.3 CDI78778.1 - 4.2 7.5 11.8 0.28 11.3 0.3 2.9 3 1 0 3 3 3 0 WW domain-binding protein 1 UPF0564 PF10595.4 CDI78778.1 - 8.6 5.1 18.0 44 2.8 12.5 1.9 1 1 1 2 2 2 0 Uncharacterised protein family UPF0564 Daxx PF03344.10 CDI78779.1 - 0.015 13.8 16.5 0.016 13.6 11.5 1.0 1 0 0 1 1 1 0 Daxx Family DUF1510 PF07423.6 CDI78779.1 - 0.077 12.3 11.9 0.096 12.0 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4307 PF14155.1 CDI78779.1 - 0.078 12.7 1.8 0.13 12.0 1.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4307) OsmC PF02566.14 CDI78779.1 - 0.11 12.6 1.0 0.23 11.6 0.7 1.5 1 1 0 1 1 1 0 OsmC-like protein DUF4045 PF13254.1 CDI78779.1 - 0.18 11.0 4.8 0.2 10.8 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Spore_coat_CotO PF14153.1 CDI78779.1 - 0.2 11.0 11.1 0.24 10.8 7.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF2052 PF09747.4 CDI78779.1 - 0.2 11.5 12.1 0.25 11.2 8.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) BUD22 PF09073.5 CDI78779.1 - 0.22 10.5 15.7 0.24 10.4 10.9 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.7 CDI78779.1 - 0.32 8.8 21.1 0.4 8.5 14.6 1.0 1 0 0 1 1 1 0 Nop14-like family CENP-T PF15511.1 CDI78779.1 - 2.7 7.1 15.8 3.2 6.8 11.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T SDA1 PF05285.7 CDI78779.1 - 3.1 7.0 19.6 3.7 6.7 13.6 1.0 1 0 0 1 1 1 0 SDA1 Ycf1 PF05758.7 CDI78779.1 - 3.9 5.0 6.6 4.2 4.9 4.6 1.0 1 0 0 1 1 1 0 Ycf1 HSP90 PF00183.13 CDI78779.1 - 4.2 5.6 12.3 6.2 5.0 8.5 1.4 1 0 0 1 1 1 0 Hsp90 protein Usp PF00582.21 CDI78779.1 - 6.3 6.9 8.6 8.1 6.6 5.9 1.3 1 0 0 1 1 1 0 Universal stress protein family VID27 PF08553.5 CDI78779.1 - 6.5 4.8 12.5 7.9 4.5 8.7 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein Myosin_head PF00063.16 CDI78780.1 - 4.6e-69 233.2 0.0 1.2e-44 152.4 0.0 2.4 2 1 1 3 3 3 2 Myosin head (motor domain) Zeta_toxin PF06414.7 CDI78780.1 - 0.0028 16.7 0.1 0.0054 15.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin ABC_tran PF00005.22 CDI78780.1 - 0.011 16.0 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_19 PF13245.1 CDI78780.1 - 0.012 15.3 0.1 0.025 14.3 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_17 PF13207.1 CDI78780.1 - 0.016 15.9 0.1 0.055 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDI78780.1 - 0.025 13.7 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Septin PF00735.13 CDI78780.1 - 0.038 13.0 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_16 PF13191.1 CDI78780.1 - 0.049 13.6 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.17 CDI78780.1 - 0.052 13.7 0.0 0.12 12.5 0.0 1.7 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.1 CDI78780.1 - 0.052 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 CDI78780.1 - 0.096 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain UPF0079 PF02367.12 CDI78780.1 - 0.097 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 CDI78780.1 - 0.11 12.0 0.3 0.17 11.4 0.2 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CDI78780.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain SNARE PF05739.14 CDI78781.1 - 2.4e-07 30.3 0.5 2.4e-07 30.3 0.3 2.1 2 0 0 2 2 2 1 SNARE domain UvsY PF11056.3 CDI78781.1 - 0.022 14.8 0.1 0.046 13.8 0.0 1.5 1 1 0 1 1 1 0 Recombination, repair and ssDNA binding protein UvsY DUF912 PF06024.7 CDI78781.1 - 0.36 10.9 5.8 0.47 10.5 0.1 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Med15 PF09606.5 CDI78781.1 - 0.85 7.7 15.5 0.92 7.6 10.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3675 PF12428.3 CDI78781.1 - 3.3 7.9 7.0 4.8 7.4 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3675) DUF4407 PF14362.1 CDI78781.1 - 6.2 5.6 12.5 23 3.8 7.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Methyltransf_26 PF13659.1 CDI78783.1 - 3.2e-10 40.0 0.0 5.4e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDI78783.1 - 2.6e-07 30.1 0.0 0.22 10.8 0.0 3.1 3 0 0 3 3 3 3 Methyltransferase small domain Methyltransf_18 PF12847.2 CDI78783.1 - 6.9e-05 23.3 0.0 0.062 13.8 0.0 2.7 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 CDI78783.1 - 0.0027 18.0 0.1 0.049 13.9 0.1 3.0 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.10 CDI78783.1 - 0.015 14.6 0.0 0.04 13.2 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein 95 TehB PF03848.9 CDI78783.1 - 0.086 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Eco57I PF07669.6 CDI78783.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase RrnaAD PF00398.15 CDI78783.1 - 0.17 10.8 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF4512 PF14975.1 CDI78786.1 - 0.18 12.6 7.9 14 6.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) IncA PF04156.9 CDI78786.1 - 0.37 10.3 0.0 0.37 10.3 0.0 2.5 3 0 0 3 3 3 0 IncA protein Neur_chan_memb PF02932.11 CDI78786.1 - 0.45 10.3 12.1 0.21 11.4 3.2 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.8 CDI78786.1 - 0.7 9.9 22.7 1.1 9.3 1.9 2.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GPCR_chapero_1 PF11904.3 CDI78786.1 - 0.86 8.6 10.7 0.18 10.9 1.6 2.1 2 0 0 2 2 2 0 GPCR-chaperone Dicty_REP PF05086.7 CDI78786.1 - 0.88 7.2 7.2 1.3 6.7 5.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF940 PF06082.6 CDI78786.1 - 1 7.8 10.4 1.6 7.1 7.2 1.2 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) DUF1510 PF07423.6 CDI78786.1 - 2.2 7.6 23.6 3.5 6.9 10.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) DUF2052 PF09747.4 CDI78786.1 - 2.8 7.8 24.8 3.7 7.4 0.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Spore_coat_CotO PF14153.1 CDI78786.1 - 6.1 6.2 31.4 0.044 13.2 12.5 2.1 2 0 0 2 2 2 0 Spore coat protein CotO DUF2201_N PF13203.1 CDI78786.1 - 7.1 5.7 24.5 2.6 7.1 10.0 2.5 2 0 0 2 2 2 0 Putative metallopeptidase domain RabGAP-TBC PF00566.13 CDI78787.1 - 7.4e-08 32.1 27.4 0.00045 19.7 0.2 5.2 5 0 0 5 5 5 3 Rab-GTPase-TBC domain Peptidase_S49_N PF08496.5 CDI78787.1 - 0.46 10.2 7.9 3.4 7.4 1.2 3.7 3 0 0 3 3 3 0 Peptidase family S49 N-terminal zf-RING_2 PF13639.1 CDI78788.1 - 5e-11 42.2 13.9 5e-11 42.2 9.6 2.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDI78788.1 - 3.1e-09 36.3 8.2 3.1e-09 36.3 5.7 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI78788.1 - 9.1e-09 35.2 13.4 9.1e-09 35.2 9.3 2.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI78788.1 - 2.4e-06 27.1 10.2 2.4e-06 27.1 7.1 3.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDI78788.1 - 4.8e-06 26.1 11.2 4.8e-06 26.1 7.7 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) TGT PF01702.13 CDI78788.1 - 2.7e-05 23.5 0.2 5.8e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase zf-RING_UBOX PF13445.1 CDI78788.1 - 5.4e-05 22.8 7.5 9.6e-05 22.0 2.9 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CDI78788.1 - 0.00013 21.7 13.7 0.00029 20.6 8.3 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CDI78788.1 - 0.0017 18.3 7.0 0.0073 16.3 4.9 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger Spt20 PF12090.3 CDI78788.1 - 0.017 14.4 13.9 0.37 10.1 2.6 3.0 2 0 0 2 2 2 0 Spt20 family zf-P11 PF03854.9 CDI78788.1 - 0.022 14.2 7.6 0.052 13.0 5.3 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-Nse PF11789.3 CDI78788.1 - 0.08 12.4 3.8 0.17 11.4 2.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FimP PF09766.4 CDI78788.1 - 1.9 7.5 23.8 1.4 7.9 3.1 2.5 2 0 0 2 2 2 0 Fms-interacting protein Prok-RING_4 PF14447.1 CDI78788.1 - 3 7.4 14.1 0.11 12.1 5.2 2.0 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 60KD_IMP PF02096.15 CDI78788.1 - 9.3 5.8 17.4 0.56 9.8 0.5 2.5 2 0 0 2 2 2 0 60Kd inner membrane protein Utp14 PF04615.8 CDI78790.1 - 7.4e-53 179.8 128.7 2.7e-36 125.0 40.1 4.1 2 1 2 4 4 4 2 Utp14 protein Med15 PF09606.5 CDI78790.1 - 1.3e-07 30.3 77.5 1.3e-07 30.3 53.7 4.1 2 1 0 3 3 3 2 ARC105 or Med15 subunit of Mediator complex non-fungal Fip1 PF05182.8 CDI78790.1 - 1.6e-06 27.2 0.5 4.5e-06 25.8 0.3 1.8 1 0 0 1 1 1 1 Fip1 motif SBDS_C PF09377.5 CDI78792.1 - 1.4e-14 53.8 0.1 1.4e-14 53.8 0.1 3.3 4 0 0 4 4 4 1 SBDS protein C-terminal domain NAD_binding_3 PF03447.11 CDI78792.1 - 0.079 13.3 0.0 0.079 13.3 0.0 3.8 4 0 0 4 4 4 0 Homoserine dehydrogenase, NAD binding domain GDI PF00996.13 CDI78794.1 - 4.8e-197 654.5 0.0 5.5e-197 654.3 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor DAO PF01266.19 CDI78794.1 - 0.0081 15.0 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase PPR_2 PF13041.1 CDI78795.1 - 8.7e-38 128.0 0.1 5e-09 35.9 0.0 6.9 3 2 5 8 8 8 7 PPR repeat family PPR_3 PF13812.1 CDI78795.1 - 8.3e-20 69.3 32.2 4.6e-05 23.3 0.2 10.7 11 0 0 11 11 11 6 Pentatricopeptide repeat domain PPR PF01535.15 CDI78795.1 - 9.5e-20 69.1 6.4 0.0023 17.8 0.1 8.1 9 0 0 9 9 9 5 PPR repeat PPR_1 PF12854.2 CDI78795.1 - 7.7e-15 54.0 0.0 0.27 10.7 0.0 7.9 9 0 0 9 9 9 4 PPR repeat OTU PF02338.14 CDI78796.1 - 5.7e-18 65.6 0.6 2.8e-17 63.4 0.0 2.6 2 0 0 2 2 2 1 OTU-like cysteine protease Asn_synthase PF00733.16 CDI78797.1 - 4.3e-51 173.8 0.0 6.2e-51 173.3 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CDI78797.1 - 1.8e-36 124.5 0.0 3.1e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CDI78797.1 - 4.3e-28 97.9 0.0 7.8e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CDI78797.1 - 5.4e-09 35.5 0.1 1.1e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 CDI78797.1 - 0.0015 17.3 0.0 0.46 9.1 0.0 2.6 1 1 2 3 3 3 2 Glutamine amidotransferases class-II DUF1933 PF09147.5 CDI78797.1 - 0.0092 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1933) Asp-Al_Ex PF06826.7 CDI78798.1 - 0.39 10.2 0.4 0.66 9.4 0.0 1.5 2 0 0 2 2 2 0 Predicted Permease Membrane Region RRM_1 PF00076.17 CDI78799.1 - 0.0043 16.6 0.0 0.0097 15.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI78799.1 - 0.0054 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_2 PF14608.1 CDI78799.1 - 3.4 7.8 7.4 7.9 6.6 5.1 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type PNK3P PF08645.6 CDI78800.1 - 0.012 15.0 0.1 0.027 13.9 0.1 1.5 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase NIF PF03031.13 CDI78800.1 - 0.023 14.3 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase zf-DHHC PF01529.15 CDI78801.1 - 6.3e-15 55.0 2.7 1.2e-14 54.0 1.9 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase TPM PF04536.9 CDI78801.1 - 3.8e-05 23.5 0.0 6.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase Fcf2 PF08698.6 CDI78804.1 - 1.2e-09 38.0 5.1 9.3e-09 35.2 0.0 3.1 2 1 0 2 2 2 1 Fcf2 pre-rRNA processing DUF898 PF05987.8 CDI78805.1 - 0.031 13.1 3.2 0.063 12.1 2.2 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DnaJ PF00226.26 CDI78807.1 - 5.4e-15 54.8 0.0 5.4e-15 54.8 0.0 2.1 2 0 0 2 2 2 1 DnaJ domain Cyt-b5 PF00173.23 CDI78808.1 - 2.7e-25 87.9 0.2 3.5e-25 87.5 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Amnionless PF14828.1 CDI78808.1 - 0.0016 17.0 0.0 0.002 16.6 0.0 1.1 1 0 0 1 1 1 1 Amnionless Intron_maturas2 PF01348.16 CDI78808.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II intron maturase DEAD PF00270.24 CDI78809.1 - 3.5e-39 133.9 0.0 7.3e-39 132.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI78809.1 - 5.5e-24 83.8 0.0 1.2e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain cNMP_binding PF00027.24 CDI78810.1 - 1.5e-18 66.3 0.0 2.8e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_6 PF13405.1 CDI78811.1 - 1.9e-11 42.8 3.1 2e-07 30.3 0.1 4.1 4 1 1 5 5 5 2 EF-hand domain EF-hand_7 PF13499.1 CDI78811.1 - 3.8e-10 39.7 0.8 1.1e-05 25.4 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDI78811.1 - 3.2e-09 35.4 2.5 2.6e-06 26.3 0.1 4.5 5 0 0 5 5 5 1 EF hand EF-hand_8 PF13833.1 CDI78811.1 - 3.8e-09 36.0 2.7 1.4e-05 24.5 0.2 3.3 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 CDI78811.1 - 0.00014 21.0 3.3 0.023 14.0 0.0 3.7 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.1 CDI78811.1 - 0.015 15.2 0.0 0.041 13.7 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain EFhand_Ca_insen PF08726.5 CDI78811.1 - 0.018 15.0 0.0 0.073 13.0 0.0 2.1 1 1 0 1 1 1 0 Ca2+ insensitive EF hand V-SNARE PF05008.10 CDI78812.1 - 5.9e-07 29.5 2.0 6.4e-07 29.4 0.2 1.9 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus ALIX_LYPXL_bnd PF13949.1 CDI78812.1 - 0.022 13.7 1.1 0.03 13.2 0.8 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV TelA PF05816.6 CDI78812.1 - 0.055 12.1 0.1 0.71 8.5 0.0 2.0 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) Med21 PF11221.3 CDI78812.1 - 0.14 12.1 1.2 0.64 9.9 0.1 2.2 3 0 0 3 3 3 0 Subunit 21 of Mediator complex HR1 PF02185.11 CDI78812.1 - 1.1 9.0 4.4 2.7 7.7 0.3 2.9 2 1 1 3 3 3 0 Hr1 repeat Mito_carr PF00153.22 CDI78813.1 - 2.5e-10 39.9 2.2 1.4e-05 24.6 0.1 2.8 2 1 0 2 2 2 2 Mitochondrial carrier protein Ribosomal_S8 PF00410.14 CDI78814.1 - 8e-25 87.1 0.0 1e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 SLBP_RNA_bind PF15247.1 CDI78815.1 - 5.9e-21 74.0 1.0 1.4e-20 72.8 0.7 1.6 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain MIP PF00230.15 CDI78816.1 - 9.3e-20 71.0 14.4 2.5e-19 69.6 10.0 1.6 1 1 0 1 1 1 1 Major intrinsic protein Mif2_N PF15624.1 CDI78817.1 - 1.5 9.4 11.9 1.8 9.1 8.2 1.1 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal MTBP_C PF14920.1 CDI78817.1 - 3.7 6.9 12.4 4.6 6.6 8.6 1.2 1 0 0 1 1 1 0 MDM2-binding SR-25 PF10500.4 CDI78817.1 - 4.5 6.6 15.4 5.6 6.3 10.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Tetraspannin PF00335.15 CDI78817.1 - 9.8 5.3 7.0 11 5.2 4.9 1.1 1 0 0 1 1 1 0 Tetraspanin family Telomere_Sde2 PF13019.1 CDI78819.1 - 1.8e-12 47.2 0.0 1.8e-12 47.2 0.0 2.4 3 0 0 3 3 3 1 Telomere stability and silencing Rotamase_2 PF13145.1 CDI78819.1 - 0.028 15.0 5.8 0.028 15.0 4.0 2.8 3 0 0 3 3 3 0 PPIC-type PPIASE domain RAP1 PF07218.6 CDI78819.1 - 0.26 9.3 7.3 0.33 8.9 5.1 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) WD40 PF00400.27 CDI78820.1 - 3e-12 45.9 3.1 1e-06 28.3 0.1 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat MMR_HSR1 PF01926.18 CDI78821.1 - 6.2e-07 29.3 0.2 3.2e-06 27.0 0.2 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase PTH2 PF01981.11 CDI78821.1 - 3.4e-06 26.7 0.0 9.7e-06 25.2 0.0 1.8 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 FeoB_N PF02421.13 CDI78821.1 - 0.00037 19.7 0.1 0.0031 16.7 0.0 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDI78821.1 - 0.00054 19.4 0.0 5.4 6.3 0.0 3.2 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 CDI78821.1 - 0.0015 18.4 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Miro PF08477.8 CDI78821.1 - 0.0026 18.2 0.1 0.057 13.9 0.0 2.6 3 0 0 3 3 3 1 Miro-like protein AAA_29 PF13555.1 CDI78821.1 - 0.028 13.9 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 CDI78821.1 - 0.064 13.2 0.1 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CDI78821.1 - 0.074 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter TPM PF04536.9 CDI78822.1 - 3.2e-08 33.4 0.1 5.1e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase Tweety PF04906.8 CDI78823.1 - 0.24 9.7 12.4 0.29 9.5 7.5 1.8 1 1 1 2 2 2 0 Tweety Nucleo_P87 PF07267.6 CDI78823.1 - 2.6 6.6 6.9 0.16 10.6 1.0 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 WD40 PF00400.27 CDI78828.1 - 3e-12 45.9 5.9 4.1e-06 26.4 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat UTP15_C PF09384.5 CDI78828.1 - 2.2e-10 40.3 0.0 4.2e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 UTP15 C terminal AAA_23 PF13476.1 CDI78828.1 - 0.18 12.0 6.2 1.6 9.0 2.2 2.2 2 0 0 2 2 2 0 AAA domain DUF3446 PF11928.3 CDI78828.1 - 2.8 8.2 13.7 8.8 6.5 5.3 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) Rotamase_2 PF13145.1 CDI78828.1 - 3.6 8.2 10.0 0.38 11.3 1.2 2.5 2 0 0 2 2 2 0 PPIC-type PPIASE domain DUF4131 PF13567.1 CDI78829.1 - 0.042 13.2 3.3 3.6 6.9 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Spt20 PF12090.3 CDI78829.1 - 0.69 9.2 13.0 5.7 6.2 0.6 3.2 3 0 0 3 3 3 0 Spt20 family Dpy-30 PF05186.8 CDI78830.1 - 4.9e-14 51.5 0.9 7.4e-14 50.9 0.6 1.3 1 0 0 1 1 1 1 Dpy-30 motif DNA_pol_A PF00476.15 CDI78831.1 - 1.4e-18 66.7 6.7 6e-08 31.7 0.0 4.4 3 2 1 4 4 4 3 DNA polymerase family A Med15 PF09606.5 CDI78831.1 - 0.0001 20.7 56.6 0.0001 20.7 39.2 2.8 3 0 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI78831.1 - 0.00064 17.5 0.9 0.00087 17.1 0.6 1.2 1 0 0 1 1 1 1 Ycf1 DUF702 PF05142.7 CDI78831.1 - 1 9.5 17.5 0.077 13.1 7.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Peptidase_S64 PF08192.6 CDI78831.1 - 2.2 6.5 10.8 3.6 5.8 7.5 1.2 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.2 CDI78831.1 - 5.1 4.6 15.7 7.5 4.0 10.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GAGA_bind PF06217.7 CDI78831.1 - 7.9 6.3 20.7 3.4 7.5 9.4 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family PAT1 PF09770.4 CDI78831.1 - 8.8 4.4 59.3 0.11 10.7 35.9 1.6 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 tRNA-synt_1c_C PF03950.13 CDI78832.1 - 0.0021 17.7 1.0 0.013 15.1 0.7 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain UB2H PF14814.1 CDI78832.1 - 0.04 13.6 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Bifunctional transglycosylase second domain DUF4097 PF13349.1 CDI78832.1 - 0.055 13.0 0.0 0.06 12.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) IncA PF04156.9 CDI78833.1 - 6.7e-05 22.5 9.4 6.7e-05 22.5 6.5 2.1 2 0 0 2 2 2 1 IncA protein DUF1510 PF07423.6 CDI78833.1 - 0.00012 21.5 3.4 0.00017 21.0 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) U79_P34 PF03064.11 CDI78833.1 - 0.00095 18.7 0.7 0.0012 18.4 0.5 1.1 1 0 0 1 1 1 1 HSV U79 / HCMV P34 DUF4175 PF13779.1 CDI78833.1 - 0.002 15.9 14.0 0.0024 15.6 9.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Suf PF05843.9 CDI78833.1 - 0.0024 17.6 0.8 0.0024 17.6 0.5 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) FHIPEP PF00771.15 CDI78833.1 - 0.0049 15.2 0.7 0.0063 14.9 0.5 1.2 1 0 0 1 1 1 1 FHIPEP family Ycf1 PF05758.7 CDI78833.1 - 0.0059 14.4 1.2 0.0063 14.3 0.8 1.0 1 0 0 1 1 1 1 Ycf1 Shisa PF13908.1 CDI78833.1 - 0.0094 16.1 0.4 0.049 13.8 0.6 1.8 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator Med15 PF09606.5 CDI78833.1 - 0.011 14.0 18.5 0.013 13.7 12.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Mem_trans PF03547.13 CDI78833.1 - 0.014 13.7 0.1 0.02 13.1 0.1 1.3 1 0 0 1 1 1 0 Membrane transport protein Claudin_2 PF13903.1 CDI78833.1 - 0.039 13.6 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF913 PF06025.7 CDI78833.1 - 0.05 12.3 1.6 0.064 11.9 1.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DHHW PF14286.1 CDI78833.1 - 0.051 12.9 5.5 0.071 12.4 3.8 1.1 1 0 0 1 1 1 0 DHHW protein DUF4199 PF13858.1 CDI78833.1 - 0.077 12.9 3.5 1 9.2 2.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4199) TRAP_alpha PF03896.11 CDI78833.1 - 0.09 11.7 2.0 0.13 11.1 1.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Ureide_permease PF07168.6 CDI78833.1 - 0.11 11.1 0.4 0.15 10.6 0.3 1.1 1 0 0 1 1 1 0 Ureide permease Git3 PF11710.3 CDI78833.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 Serinc PF03348.10 CDI78833.1 - 0.17 10.5 3.7 0.22 10.1 2.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.11 CDI78833.1 - 0.18 11.6 0.2 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3537 PF12056.3 CDI78833.1 - 0.2 10.3 0.6 0.26 9.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) AIF_C PF14721.1 CDI78833.1 - 0.48 10.6 3.9 0.82 9.9 2.7 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Bud13 PF09736.4 CDI78833.1 - 0.79 9.9 13.3 1.1 9.4 9.2 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Presenilin PF01080.12 CDI78833.1 - 0.83 8.4 4.3 1.1 7.9 3.0 1.2 1 0 0 1 1 1 0 Presenilin DUF1764 PF08576.5 CDI78833.1 - 1.4 9.7 10.4 2.3 9.0 7.2 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) FimP PF09766.4 CDI78833.1 - 1.5 7.7 16.6 2.2 7.2 11.5 1.1 1 0 0 1 1 1 0 Fms-interacting protein FYDLN_acid PF09538.5 CDI78833.1 - 1.8 9.1 9.1 0.21 12.1 3.4 1.6 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) Gag_spuma PF03276.9 CDI78833.1 - 2.5 6.2 13.3 3.5 5.8 9.2 1.2 1 0 0 1 1 1 0 Spumavirus gag protein RR_TM4-6 PF06459.7 CDI78833.1 - 3.9 7.2 10.8 6.6 6.5 7.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3373 PF11853.3 CDI78833.1 - 4.2 5.7 7.3 5.5 5.3 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Pex16 PF08610.5 CDI78833.1 - 4.8 6.0 8.3 6.6 5.6 5.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) FAM176 PF14851.1 CDI78833.1 - 9.5 5.8 8.6 20 4.8 6.0 1.6 1 1 0 1 1 1 0 FAM176 family Zip PF02535.17 CDI78834.1 - 0.00046 19.2 13.1 0.00046 19.2 9.1 3.1 2 1 0 3 3 3 1 ZIP Zinc transporter SelP_N PF04592.9 CDI78834.1 - 0.88 8.9 22.9 2.9 7.1 15.9 1.9 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Innate_immun PF12782.2 CDI78834.1 - 6.4 5.9 19.9 15 4.6 13.8 1.6 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Neur_chan_memb PF02932.11 CDI78834.1 - 6.5 6.5 18.3 1.3 8.8 4.1 3.0 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region P12 PF12669.2 CDI78836.1 - 0.017 15.2 5.2 0.46 10.7 0.0 2.8 2 0 0 2 2 2 0 Virus attachment protein p12 family Cellulose_synt PF03552.9 CDI78836.1 - 2 6.5 4.0 3.2 5.9 2.8 1.2 1 0 0 1 1 1 0 Cellulose synthase RHD3 PF05879.7 CDI78838.1 - 1.3e-102 344.0 4.8 2.1e-88 297.1 0.0 2.9 3 0 0 3 3 3 2 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.18 CDI78838.1 - 0.0008 19.2 0.1 0.0008 19.2 0.1 3.1 2 2 0 2 2 1 1 Dynamin family MMR_HSR1 PF01926.18 CDI78838.1 - 0.0022 17.9 0.0 0.0061 16.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.1 CDI78838.1 - 0.036 13.6 0.1 0.1 12.1 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 CDI78838.1 - 0.069 13.0 0.4 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Ribosomal_60s PF00428.14 CDI78838.1 - 0.071 13.5 0.4 0.071 13.5 0.3 4.2 4 0 0 4 4 3 0 60s Acidic ribosomal protein AAA_23 PF13476.1 CDI78838.1 - 0.078 13.2 0.0 0.078 13.2 0.0 3.2 3 0 0 3 3 2 0 AAA domain Miro PF08477.8 CDI78838.1 - 0.15 12.6 2.4 0.2 12.1 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein AAA_28 PF13521.1 CDI78838.1 - 0.15 11.9 0.0 0.15 11.9 0.0 3.1 3 0 0 3 3 2 0 AAA domain Cyt_c_ox_IV PF12270.3 CDI78838.1 - 0.3 10.8 0.0 0.3 10.8 0.0 2.0 2 0 0 2 2 1 0 Cytochrome c oxidase subunit IV DDHD PF02862.12 CDI78838.1 - 0.6 9.8 19.9 4.4 7.0 8.1 2.6 2 0 0 2 2 2 0 DDHD domain Plasmodium_Vir PF05795.6 CDI78838.1 - 0.78 8.8 6.3 3.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Plasmodium vivax Vir protein PAT1 PF09770.4 CDI78838.1 - 2.1 6.4 42.0 5.1 5.2 29.1 1.6 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Septin PF00735.13 CDI78838.1 - 2.3 7.1 7.0 0.25 10.3 0.2 2.4 2 0 0 2 2 2 0 Septin DUF3529 PF12046.3 CDI78839.1 - 0.015 14.3 0.6 0.027 13.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3529) tRNA-synt_1 PF00133.17 CDI78840.1 - 1e-25 89.8 1.4 6e-10 37.7 0.0 5.4 5 1 1 6 6 6 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 CDI78840.1 - 1.3e-16 60.2 0.1 7.2e-06 24.8 0.0 3.9 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 CDI78840.1 - 4.4e-11 42.7 0.6 1.9e-10 40.6 0.4 2.0 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA SR-25 PF10500.4 CDI78840.1 - 4e-06 26.4 13.2 4e-06 26.4 9.1 7.3 5 2 2 7 7 7 1 Nuclear RNA-splicing-associated protein tRNA-synt_1_2 PF13603.1 CDI78840.1 - 0.0013 18.0 0.0 0.005 16.1 0.0 2.0 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 DUF155 PF02582.9 CDI78842.1 - 1.2e-22 80.6 0.1 2e-22 79.9 0.0 1.4 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 Ribosomal_S16 PF00886.14 CDI78843.1 - 0.13 11.9 0.7 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S16 Pex14_N PF04695.8 CDI78843.1 - 3.7 7.5 20.8 4.7 7.2 12.4 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.4 CDI78843.1 - 4.1 6.8 21.6 0.11 11.9 9.7 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein WD40 PF00400.27 CDI78845.1 - 0.001 18.8 1.1 3.2 7.7 0.0 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat GAS PF13851.1 CDI78846.1 - 3.5e-26 91.6 15.2 3.5e-26 91.6 10.5 3.3 1 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding IncA PF04156.9 CDI78846.1 - 1.6 8.3 50.6 2 7.9 11.8 4.2 2 1 2 4 4 4 0 IncA protein GABP-alpha PF11620.3 CDI78846.1 - 3.3 7.7 6.3 1.8 8.6 0.2 3.0 3 0 0 3 3 3 0 GA-binding protein alpha chain Reo_sigmaC PF04582.7 CDI78846.1 - 6.7 5.7 8.7 1.5 7.9 0.2 2.8 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Spc97_Spc98 PF04130.8 CDI78847.1 - 3.9e-13 48.5 0.1 2.7e-11 42.4 0.0 3.6 2 1 0 2 2 2 1 Spc97 / Spc98 family AAA_23 PF13476.1 CDI78848.1 - 0.0049 17.2 14.4 0.0055 17.0 10.0 1.2 1 0 0 1 1 1 1 AAA domain SprA-related PF12118.3 CDI78848.1 - 0.047 13.0 45.3 0.065 12.5 31.4 1.1 1 0 0 1 1 1 0 SprA-related family Ycf1 PF05758.7 CDI78848.1 - 0.17 9.5 12.5 0.15 9.7 8.7 1.2 1 0 0 1 1 1 0 Ycf1 RAP1 PF07218.6 CDI78848.1 - 0.36 8.8 1.7 0.46 8.5 1.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2126 PF09899.4 CDI78848.1 - 0.41 8.6 10.6 0.36 8.8 7.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FHIPEP PF00771.15 CDI78848.1 - 0.46 8.7 6.0 0.51 8.6 4.2 1.3 1 0 0 1 1 1 0 FHIPEP family RR_TM4-6 PF06459.7 CDI78848.1 - 1.8 8.3 23.4 2.2 8.1 16.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.4 CDI78848.1 - 1.8 7.2 16.0 2.7 6.7 11.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain MRP-S31 PF15433.1 CDI78848.1 - 4.7 6.5 24.9 6.3 6.1 17.3 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 FYDLN_acid PF09538.5 CDI78848.1 - 6.4 7.4 10.8 2.2 8.8 5.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Cellulose_synt PF03552.9 CDI78848.1 - 7.3 4.7 7.1 8.4 4.5 4.9 1.1 1 0 0 1 1 1 0 Cellulose synthase PAT1 PF09770.4 CDI78848.1 - 8.6 4.4 53.7 9.4 4.3 37.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TPR_2 PF07719.12 CDI78849.1 - 1.1e-07 31.1 31.6 0.0001 21.9 0.8 8.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 CDI78849.1 - 9.1e-06 26.2 15.6 0.0001 22.8 0.5 16.4 15 3 1 16 16 16 5 Tetratricopeptide repeat TPR_11 PF13414.1 CDI78849.1 - 0.00014 21.4 53.0 0.0097 15.5 0.7 9.7 10 1 0 10 10 10 5 TPR repeat TPR_1 PF00515.23 CDI78849.1 - 0.0053 16.3 0.3 0.0053 16.3 0.2 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDI78849.1 - 0.0066 16.1 0.0 4.1 7.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI78849.1 - 0.13 12.9 0.0 0.13 12.9 0.0 15.1 13 3 3 16 16 16 0 Tetratricopeptide repeat TAXi_N PF14543.1 CDI78851.1 - 2.9e-08 33.8 3.7 2.9e-08 33.8 2.6 1.6 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp PF00026.18 CDI78851.1 - 0.0014 17.9 0.1 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease DUF755 PF05501.6 CDI78851.1 - 0.019 14.9 3.2 0.019 14.9 2.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) RCC1 PF00415.13 CDI78852.1 - 6.2e-17 61.5 10.5 2.6e-06 27.5 0.1 7.2 6 3 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI78852.1 - 2.7e-16 58.6 24.9 1.4e-06 27.7 0.0 7.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Kelch_2 PF07646.10 CDI78852.1 - 0.29 10.9 3.2 10 6.0 0.0 3.7 3 0 0 3 3 3 0 Kelch motif Terminase_GpA PF05876.7 CDI78853.1 - 0.049 11.9 0.1 0.053 11.8 0.0 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) EamA PF00892.15 CDI78854.1 - 7.8e-07 29.1 1.7 7.8e-07 29.1 1.2 2.6 2 1 0 2 2 2 1 EamA-like transporter family Nuc_sug_transp PF04142.10 CDI78854.1 - 0.00019 20.6 0.2 0.00042 19.4 0.1 1.6 1 1 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.11 CDI78854.1 - 0.0012 18.5 0.6 0.0012 18.5 0.4 3.1 2 1 0 3 3 3 1 Triose-phosphate Transporter family MMPL PF03176.10 CDI78854.1 - 1.5 7.4 8.5 0.22 10.2 2.4 2.2 3 0 0 3 3 3 0 MMPL family EmrE PF13536.1 CDI78854.1 - 5.2 7.3 19.7 0.14 12.3 5.3 3.7 2 2 1 3 3 3 0 Multidrug resistance efflux transporter Hexapep PF00132.19 CDI78856.1 - 0.00015 21.0 15.0 0.0018 17.7 0.5 4.1 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Mito_carr PF00153.22 CDI78857.1 - 5.4e-08 32.4 0.0 5.4e-08 32.4 0.0 2.8 1 1 2 3 3 2 1 Mitochondrial carrier protein OmpH PF03938.9 CDI78857.1 - 0.0065 16.4 11.9 0.0096 15.8 8.3 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) DUF2383 PF09537.5 CDI78857.1 - 0.085 13.1 1.5 0.13 12.5 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) FCP1_C PF09309.5 CDI78857.1 - 0.19 11.0 4.2 0.23 10.7 2.9 1.1 1 0 0 1 1 1 0 FCP1, C-terminal UPF0560 PF10577.4 CDI78857.1 - 0.54 8.4 8.7 0.63 8.2 6.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4557 PF15101.1 CDI78857.1 - 0.57 9.9 8.1 0.68 9.7 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF3552 PF12072.3 CDI78857.1 - 0.61 9.2 11.1 0.87 8.7 7.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Suf PF05843.9 CDI78857.1 - 0.63 9.7 6.7 0.73 9.5 4.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3373 PF11853.3 CDI78857.1 - 0.69 8.3 4.3 0.75 8.2 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF4175 PF13779.1 CDI78857.1 - 1.2 6.7 16.9 1.3 6.6 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Med15 PF09606.5 CDI78857.1 - 1.8 6.6 25.5 2 6.4 17.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RED_N PF07808.8 CDI78857.1 - 3.8 6.6 12.3 5.7 6.0 8.6 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF208 PF02677.9 CDI78858.1 - 0.029 14.1 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized BCR, COG1636 Utp14 PF04615.8 CDI78859.1 - 0.059 11.5 40.7 0.029 12.5 9.0 2.2 2 0 0 2 2 2 0 Utp14 protein SAPS PF04499.10 CDI78859.1 - 0.25 9.9 26.3 0.27 9.8 6.7 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Daxx PF03344.10 CDI78859.1 - 0.33 9.3 41.2 0.82 8.0 11.2 2.1 2 0 0 2 2 2 0 Daxx Family DUF2370 PF10176.4 CDI78859.1 - 1.1 8.5 14.4 0.29 10.4 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Zip PF02535.17 CDI78859.1 - 1.5 7.7 14.1 1.6 7.6 2.4 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter SOBP PF15279.1 CDI78859.1 - 2.6 8.3 24.2 4.6 7.5 7.0 2.4 2 0 0 2 2 2 0 Sine oculis-binding protein Ycf1 PF05758.7 CDI78859.1 - 4.1 4.9 31.6 2.3 5.8 9.7 2.2 2 0 0 2 2 2 0 Ycf1 Gti1_Pac2 PF09729.4 CDI78859.1 - 5.7 6.7 21.1 6.9 6.5 5.7 2.6 2 0 0 2 2 2 0 Gti1/Pac2 family Herpes_UL87 PF03043.9 CDI78859.1 - 5.8 5.1 7.9 3.1 6.0 0.3 2.3 2 0 0 2 2 2 0 Herpesvirus UL87 family Tim54 PF11711.3 CDI78859.1 - 5.8 5.3 20.7 5.1 5.5 6.6 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4175 PF13779.1 CDI78860.1 - 0.0014 16.4 16.9 0.0014 16.4 11.7 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4175) FimP PF09766.4 CDI78860.1 - 1.1 8.2 34.5 0.11 11.4 10.1 2.2 2 0 0 2 2 2 0 Fms-interacting protein Bap31 PF05529.7 CDI78860.1 - 6.5 6.1 12.4 0.17 11.3 0.7 2.6 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like GILT PF03227.11 CDI78862.1 - 1e-16 60.7 0.1 2.6e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) HECT PF00632.20 CDI78863.1 - 1.2e-56 192.1 0.0 2.4e-56 191.2 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4411 PF14367.1 CDI78863.1 - 0.13 11.9 2.2 0.52 10.0 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4411) Macoilin PF09726.4 CDI78863.1 - 6.1 4.9 49.5 0.81 7.8 11.1 3.9 3 0 0 3 3 3 0 Transmembrane protein DUF4605 PF15378.1 CDI78864.1 - 0.11 12.2 0.9 0.31 10.7 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4605) SynMuv_product PF06047.6 CDI78866.1 - 8.9e-50 166.8 3.0 8.9e-50 166.8 2.1 2.2 2 0 0 2 2 2 1 Ras-induced vulval development antagonist DUF3006 PF11213.3 CDI78866.1 - 0.016 14.9 0.5 0.016 14.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) Collar PF07484.7 CDI78866.1 - 0.05 13.4 0.3 0.13 12.0 0.1 1.7 2 0 0 2 2 2 0 Phage Tail Collar Domain DUF808 PF05661.7 CDI78866.1 - 0.23 10.2 0.2 0.47 9.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF808) LMBR1 PF04791.11 CDI78866.1 - 0.55 8.7 3.9 1.5 7.3 3.2 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein Orthopox_A36R PF05950.6 CDI78866.1 - 5.1 7.0 8.8 3.5 7.5 1.3 2.3 2 0 0 2 2 2 0 Orthopoxvirus A36R protein tRNA-synt_1b PF00579.20 CDI78867.1 - 8.9e-08 31.5 0.0 2.2e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_60s PF00428.14 CDI78867.1 - 0.00014 22.1 7.6 0.0079 16.5 0.7 2.9 2 0 0 2 2 2 2 60s Acidic ribosomal protein DUF1180 PF06679.7 CDI78867.1 - 0.022 14.6 0.2 0.049 13.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RskA PF10099.4 CDI78867.1 - 0.094 12.4 5.8 0.47 10.1 1.4 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA HSP70 PF00012.15 CDI78868.1 - 2.1e-18 65.6 9.7 2.1e-06 25.9 0.0 4.8 2 1 2 4 4 4 3 Hsp70 protein TPR_11 PF13414.1 CDI78868.1 - 6.6e-09 35.3 21.0 9e-06 25.2 1.1 4.0 4 0 0 4 4 4 2 TPR repeat Fis1_TPR_C PF14853.1 CDI78868.1 - 3.4e-05 23.6 3.1 5e-05 23.1 0.4 2.8 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 CDI78868.1 - 0.0036 16.8 8.7 0.0076 15.8 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3115 PF11312.3 CDI78868.1 - 0.0099 14.7 4.1 0.073 11.9 0.4 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF3115) DUF2722 PF10846.3 CDI78868.1 - 0.016 14.2 10.1 0.64 8.9 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) TPR_2 PF07719.12 CDI78868.1 - 0.025 14.4 0.2 0.025 14.4 0.2 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat RAB3GAP2_N PF14655.1 CDI78868.1 - 0.11 11.4 9.6 0.27 10.2 0.1 3.2 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus WES_acyltransf PF03007.11 CDI78868.1 - 0.33 10.4 5.8 0.49 9.9 0.1 3.0 3 0 0 3 3 3 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Chorion_2 PF03964.10 CDI78868.1 - 1.2 9.6 8.4 9 6.9 0.6 2.9 2 0 0 2 2 2 0 Chorion family 2 DUF3292 PF11696.3 CDI78871.1 - 0.091 10.6 9.8 0.063 11.1 6.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3292) TerB-C PF15615.1 CDI78871.1 - 1.7 8.8 8.5 2.6 8.2 5.9 1.3 1 0 0 1 1 1 0 TerB-C domain DUF2277 PF10041.4 CDI78871.1 - 5.9 6.9 13.0 0.097 12.6 2.8 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) Herpes_LMP2 PF07415.6 CDI78873.1 - 0.0032 16.1 6.0 0.0032 16.1 4.1 3.4 4 0 0 4 4 4 1 Gammaherpesvirus latent membrane protein (LMP2) protein RskA PF10099.4 CDI78875.1 - 0.0017 18.1 6.1 0.0017 18.1 4.2 1.9 2 0 0 2 2 2 1 Anti-sigma-K factor rskA K_channel_TID PF07941.6 CDI78875.1 - 0.0041 17.3 4.3 0.014 15.6 3.0 1.9 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain TAF1D PF15333.1 CDI78875.1 - 0.088 12.5 2.2 0.12 12.1 1.5 1.2 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D AAA_23 PF13476.1 CDI78875.1 - 0.41 10.9 6.9 0.53 10.5 4.8 1.1 1 0 0 1 1 1 0 AAA domain Med15 PF09606.5 CDI78875.1 - 1.1 7.3 34.5 1.3 7.1 23.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.4 CDI78875.1 - 1.3 8.4 14.7 1.3 8.4 9.2 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.14 CDI78875.1 - 1.4 9.3 12.1 2.4 8.5 8.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Activator_LAG-3 PF11498.3 CDI78875.1 - 1.5 7.5 35.1 1.8 7.2 24.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SpaB_C PF14028.1 CDI78875.1 - 1.6 8.1 9.9 2.2 7.7 6.9 1.2 1 0 0 1 1 1 0 SpaB C-terminal domain AIP3 PF03915.8 CDI78875.1 - 3.3 6.5 9.6 3.8 6.3 6.7 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Peptidase_S64 PF08192.6 CDI78875.1 - 7.9 4.6 10.3 9.5 4.4 7.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Med15 PF09606.5 CDI78879.1 - 0.035 12.3 29.1 0.037 12.2 20.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_assoc PF14363.1 CDI78879.1 - 0.037 14.0 0.1 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA NAM-associated PF14303.1 CDI78879.1 - 0.08 13.2 9.4 0.12 12.7 6.5 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Pox_A_type_inc PF04508.7 CDI78879.1 - 0.12 12.1 3.7 0.31 10.9 2.5 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Exonuc_VII_L PF02601.10 CDI78879.1 - 0.17 11.0 9.3 0.21 10.7 6.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4415 PF14384.1 CDI78879.1 - 0.24 11.5 2.2 0.63 10.2 1.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4415) DUF4298 PF14131.1 CDI78879.1 - 0.52 10.2 7.4 0.97 9.3 5.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) V_ATPase_I PF01496.14 CDI78879.1 - 1.4 6.6 6.2 1.3 6.8 4.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF745 PF05335.8 CDI78879.1 - 2.4 7.6 9.1 4.2 6.8 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Atg14 PF10186.4 CDI78879.1 - 5.5 5.8 16.8 9.3 5.0 11.5 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 bcl-2I13 PF12201.3 CDI78881.1 - 0.052 13.0 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Bcl2-interacting killer, BH3-domain containing Baculo_PP31 PF05311.6 CDI78881.1 - 1.6 7.9 7.1 2.7 7.2 4.9 1.5 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Neur_chan_memb PF02932.11 CDI78881.1 - 5.6 6.7 9.7 2.8 7.7 4.5 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Med15 PF09606.5 CDI78882.1 - 0.055 11.6 48.4 0.08 11.1 33.5 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal GAGA_bind PF06217.7 CDI78882.1 - 1.9 8.3 21.7 2.9 7.7 15.0 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Kelch_5 PF13854.1 CDI78884.1 - 1.7e-10 40.5 0.1 5.2e-08 32.6 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 CDI78884.1 - 2.3e-08 33.6 0.2 0.0015 18.2 0.0 4.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 CDI78884.1 - 5.9e-05 23.1 15.9 0.076 13.2 0.0 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 CDI78884.1 - 0.00017 21.6 1.5 0.028 14.6 0.0 4.3 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.20 CDI78884.1 - 0.013 15.0 0.1 0.35 10.4 0.0 3.2 3 0 0 3 3 3 0 Kelch motif UPF0203 PF05254.7 CDI78885.1 - 1.2e-17 63.4 1.2 1.8e-17 62.9 0.8 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) CMV_1a PF12467.3 CDI78885.1 - 0.037 14.3 3.2 0.048 14.0 2.2 1.2 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Tmemb_cc2 PF10267.4 CDI78885.1 - 0.19 10.2 8.1 0.24 9.9 5.6 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Peptidase_S64 PF08192.6 CDI78885.1 - 0.53 8.5 7.1 0.57 8.4 4.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 RAP1 PF07218.6 CDI78885.1 - 3.2 5.7 11.2 4.2 5.3 7.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) zf-RING_2 PF13639.1 CDI78887.1 - 8.8e-14 51.0 8.4 2.6e-13 49.5 5.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDI78887.1 - 3.7e-08 33.3 3.2 3.7e-08 33.3 2.2 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 CDI78887.1 - 1.7e-06 27.6 6.5 4.4e-06 26.3 4.5 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDI78887.1 - 2.2e-06 27.5 8.7 6.5e-06 26.0 6.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDI78887.1 - 5.7e-06 25.9 7.4 5.7e-06 25.9 5.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI78887.1 - 0.00019 21.0 7.1 0.00019 21.0 4.9 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDI78887.1 - 0.11 12.2 4.7 0.37 10.6 3.3 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TFIIA PF03153.8 CDI78887.1 - 1.3 8.8 17.8 0.09 12.6 8.4 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-P11 PF03854.9 CDI78887.1 - 3.7 7.1 8.5 1.1 8.8 3.3 2.1 2 1 0 2 2 2 0 P-11 zinc finger MOZ_SAS PF01853.13 CDI78888.1 - 4.4e-48 163.0 1.0 9.2e-46 155.4 0.3 3.0 2 1 0 2 2 2 2 MOZ/SAS family Tudor-knot PF11717.3 CDI78888.1 - 1.7e-10 40.4 0.0 9.9e-10 37.9 0.0 2.1 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain PP2C PF00481.16 CDI78890.1 - 2.1e-35 122.3 0.0 1e-34 120.0 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.7 CDI78890.1 - 0.0051 16.5 0.0 0.27 10.9 0.0 2.6 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) PAT1 PF09770.4 CDI78891.1 - 0.39 8.8 45.8 0.5 8.5 31.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 E1-E2_ATPase PF00122.15 CDI78892.1 - 7.5e-55 185.4 2.0 1.4e-54 184.5 1.4 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CDI78892.1 - 3.7e-30 105.9 0.0 9.9e-30 104.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CDI78892.1 - 1.1e-19 69.6 0.0 2.7e-19 68.3 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 CDI78892.1 - 5.7e-15 55.0 0.0 2.1e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_C PF00689.16 CDI78892.1 - 4.7e-12 45.7 0.7 4.5e-11 42.6 0.0 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus HAD PF12710.2 CDI78892.1 - 1.3e-11 45.0 2.3 4e-11 43.4 1.6 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDI78892.1 - 0.0036 16.9 1.3 0.0058 16.2 0.4 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Spc7 PF08317.6 CDI78892.1 - 1.2 7.7 16.3 4.3 5.9 11.2 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein ATPase_gene1 PF09527.5 CDI78892.1 - 3.2 7.6 6.8 0.35 10.7 0.8 2.4 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit (ATPase_gene1) Ribosomal_60s PF00428.14 CDI78893.1 - 4.9 7.6 9.9 12 6.3 6.8 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein WD40 PF00400.27 CDI78896.1 - 1.7e-07 30.8 2.5 0.00026 20.7 0.2 3.6 4 0 0 4 4 4 2 WD domain, G-beta repeat SR-25 PF10500.4 CDI78896.1 - 4e-05 23.2 21.6 4e-05 23.2 15.0 4.3 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein SAPS PF04499.10 CDI78896.1 - 0.057 12.0 19.1 0.35 9.4 6.2 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Macoilin PF09726.4 CDI78896.1 - 0.058 11.6 34.7 0.058 11.6 6.1 2.3 2 0 0 2 2 2 0 Transmembrane protein Mem_trans PF03547.13 CDI78896.1 - 0.79 7.9 13.0 0.77 7.9 1.2 2.3 2 0 0 2 2 2 0 Membrane transport protein DUF572 PF04502.8 CDI78896.1 - 1.2 8.2 36.4 0.015 14.5 7.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) PAT1 PF09770.4 CDI78896.1 - 7.2 4.7 60.7 1.9 6.6 24.6 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 D5_N PF08706.6 CDI78897.1 - 0.46 10.5 2.5 0.92 9.5 1.7 1.4 1 0 0 1 1 1 0 D5 N terminal like Antimicrobial_4 PF08024.6 CDI78898.1 - 0.75 9.7 8.8 77 3.2 0.1 4.7 4 0 0 4 4 4 0 Ant antimicrobial peptide Dpy19 PF10034.4 CDI78901.1 - 9.7 4.2 0.5 25 2.8 0.3 1.6 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Methyltransf_18 PF12847.2 CDI78906.1 - 7.6e-08 32.9 0.0 6.9e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI78906.1 - 1.2e-05 24.9 0.0 4.6e-05 23.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI78906.1 - 0.00012 22.4 0.0 0.00074 19.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI78906.1 - 0.0012 19.2 0.0 0.004 17.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI78906.1 - 0.0036 17.7 0.0 0.11 12.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI78906.1 - 0.01 15.5 0.0 0.16 11.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI78906.1 - 0.013 15.5 0.0 0.078 13.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.21 CDI78906.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase LRR_8 PF13855.1 CDI78908.1 - 2.1e-06 27.3 0.9 0.011 15.4 0.0 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 CDI78908.1 - 4.7e-05 22.9 2.0 0.051 13.2 0.2 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 CDI78908.1 - 0.0039 17.1 0.4 1.8 9.0 0.0 2.8 2 1 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.1 CDI78908.1 - 0.0055 16.6 2.0 1.7 8.9 0.1 3.1 2 1 0 2 2 2 2 Leucine Rich repeat FHIPEP PF00771.15 CDI78908.1 - 0.012 14.0 1.9 0.016 13.5 1.3 1.1 1 0 0 1 1 1 0 FHIPEP family PHD_3 PF13922.1 CDI78908.1 - 0.11 12.7 1.7 0.36 11.0 1.2 1.9 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx LRR_1 PF00560.28 CDI78908.1 - 0.18 11.9 1.9 22 5.5 0.1 3.4 2 1 1 3 3 3 0 Leucine Rich Repeat Suf PF05843.9 CDI78908.1 - 0.61 9.7 6.6 0.98 9.0 4.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) AF-4 PF05110.8 CDI78909.1 - 1.3 6.7 37.5 1.5 6.5 26.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MIP-T3 PF10243.4 CDI78909.1 - 2.1 6.6 53.7 2.3 6.6 37.2 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CAF-1_p150 PF11600.3 CDI78909.1 - 3.2 7.0 53.6 4.3 6.6 37.1 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Pkinase PF00069.20 CDI78910.1 - 1.5e-20 73.4 6.6 6.1e-08 32.1 0.0 4.8 4 1 1 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78910.1 - 0.00026 20.1 1.8 0.00026 20.1 1.2 3.2 3 1 0 3 3 3 1 Protein tyrosine kinase OmpH PF03938.9 CDI78910.1 - 0.0013 18.7 15.3 0.0013 18.7 10.6 5.0 3 2 0 3 3 3 1 Outer membrane protein (OmpH-like) Spore_coat_CotO PF14153.1 CDI78910.1 - 1.3 8.4 61.2 0.023 14.1 11.5 5.1 5 0 0 5 5 5 0 Spore coat protein CotO GTP_EFTU PF00009.22 CDI78914.1 - 4e-26 91.6 0.0 2.1e-25 89.2 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 CDI78914.1 - 9.1e-09 35.1 0.3 3e-07 30.3 0.1 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.18 CDI78914.1 - 2.7e-05 24.0 0.0 6e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CDI78914.1 - 0.00065 19.5 0.0 0.02 14.7 0.0 2.2 2 0 0 2 2 2 1 Dynamin family Miro PF08477.8 CDI78914.1 - 0.0045 17.4 0.0 0.17 12.3 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein PduV-EutP PF10662.4 CDI78914.1 - 0.0079 15.6 0.3 1.2 8.6 0.0 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Pkinase PF00069.20 CDI78916.1 - 2.6e-16 59.5 0.0 2.6e-16 59.5 0.0 4.1 2 2 2 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI78916.1 - 1.3e-07 30.9 0.0 1.3e-07 30.9 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Spore_coat_CotO PF14153.1 CDI78916.1 - 0.85 9.0 56.1 0.16 11.4 5.4 3.3 3 0 0 3 3 3 0 Spore coat protein CotO Med15 PF09606.5 CDI78917.1 - 0.0094 14.2 73.7 0.01 14.0 51.1 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI78917.1 - 0.3 9.2 63.0 0.35 9.0 43.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4045 PF13254.1 CDI78917.1 - 0.74 9.0 19.3 0.82 8.8 13.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CRT10 PF08728.5 CDI78917.1 - 6.6 4.5 18.3 6.9 4.5 12.7 1.0 1 0 0 1 1 1 0 CRT10 S_tail_recep_bd PF14928.1 CDI78918.1 - 0.1 12.8 2.9 0.12 12.5 2.0 1.3 1 1 0 1 1 1 0 Short tail fibre protein receptor-binding domain Tubulin_3 PF14881.1 CDI78918.1 - 0.38 10.2 2.0 0.43 10.0 1.4 1.1 1 0 0 1 1 1 0 Tubulin domain Herpes_capsid PF06112.6 CDI78918.1 - 0.91 9.5 23.0 1 9.4 15.9 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SbcCD_C PF13558.1 CDI78918.1 - 1.7 8.5 5.1 2.4 8.1 3.5 1.3 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF4175 PF13779.1 CDI78918.1 - 2.9 5.4 9.1 2.6 5.6 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) MSP1_C PF07462.6 CDI78918.1 - 3.5 5.9 6.4 3.7 5.8 4.4 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Plasmodium_Vir PF05795.6 CDI78918.1 - 5.9 5.9 8.1 6.2 5.9 5.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Neur_chan_memb PF02932.11 CDI78918.1 - 8.6 6.1 8.6 8.9 6.1 6.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4557 PF15101.1 CDI78918.1 - 8.8 6.1 11.5 5.4 6.7 7.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4557) DUF2217 PF10265.4 CDI78918.1 - 9.2 4.8 21.4 11 4.7 14.8 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) PT PF04886.7 CDI78919.1 - 0.0021 17.3 0.3 0.0021 17.3 0.2 4.2 4 0 0 4 4 4 1 PT repeat DUF966 PF06136.8 CDI78919.1 - 0.65 9.3 7.6 1.1 8.6 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Rifin_STEVOR PF02009.11 CDI78919.1 - 3.7 7.0 3.6 6.1 6.3 2.5 1.3 1 0 0 1 1 1 0 Rifin/stevor family Ycf1 PF05758.7 CDI78920.1 - 0.00016 19.6 0.5 0.00017 19.4 0.4 1.0 1 0 0 1 1 1 1 Ycf1 IncA PF04156.9 CDI78920.1 - 0.0069 15.9 35.7 0.017 14.7 1.9 2.6 2 1 0 2 2 2 2 IncA protein PglZ PF08665.7 CDI78920.1 - 0.012 15.2 4.5 0.012 15.2 3.1 1.8 2 1 0 2 2 1 0 PglZ domain COX14 PF14880.1 CDI78920.1 - 0.02 14.5 1.5 0.02 14.5 1.0 3.4 3 1 0 3 3 1 0 Cytochrome oxidase c assembly Hid1 PF12722.2 CDI78920.1 - 0.025 12.2 4.4 0.029 12.0 3.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Claudin_2 PF13903.1 CDI78920.1 - 0.048 13.3 0.5 0.048 13.3 0.3 3.7 3 1 0 3 3 2 0 PMP-22/EMP/MP20/Claudin tight junction SpoVR PF04293.8 CDI78920.1 - 0.24 9.7 11.1 0.43 8.8 7.7 1.3 1 0 0 1 1 1 0 SpoVR like protein EphA2_TM PF14575.1 CDI78920.1 - 0.68 10.3 0.1 0.68 10.3 0.1 2.6 3 0 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain Neur_chan_memb PF02932.11 CDI78920.1 - 1.1 9.1 3.7 0.3 10.9 0.8 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Band_3_cyto PF07565.8 CDI78920.1 - 1.9 7.9 9.3 0.062 12.8 2.1 1.8 2 0 0 2 2 2 0 Band 3 cytoplasmic domain PRP1_N PF06424.7 CDI78920.1 - 1.9 8.8 11.8 1.7 8.9 5.7 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal CD20 PF04103.10 CDI78920.1 - 3.3 7.6 5.8 37 4.2 4.0 2.4 1 1 0 1 1 1 0 CD20-like family Spore_YhcN_YlaJ PF09580.5 CDI78920.1 - 4 7.5 10.8 1.2 9.2 5.4 1.7 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF106 PF01956.11 CDI78920.1 - 4.2 6.8 13.6 0.1 12.1 3.6 2.0 2 0 0 2 2 2 0 Integral membrane protein DUF106 Presenilin PF01080.12 CDI78920.1 - 6.6 5.4 10.4 4.3 6.0 6.0 1.5 1 1 0 1 1 1 0 Presenilin Baculo_PP31 PF05311.6 CDI78920.1 - 6.6 5.9 10.0 12 5.0 7.0 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) HlyD_2 PF12700.2 CDI78920.1 - 8.1 5.4 15.1 0.18 10.9 4.9 1.9 2 0 0 2 2 2 0 HlyD family secretion protein FAM60A PF15396.1 CDI78920.1 - 8.4 6.0 10.2 0.89 9.2 4.0 1.6 2 0 0 2 2 2 0 Protein Family FAM60A VRR_NUC PF08774.6 CDI78921.1 - 4.3e-13 49.1 2.5 1.4e-11 44.2 1.7 3.0 1 1 0 1 1 1 1 VRR-NUC domain Ribosomal_S11 PF00411.14 CDI78925.1 - 5.4e-27 94.1 0.8 6.3e-27 93.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_S11 PF00411.14 CDI78927.1 - 5.6e-42 142.3 0.5 5.6e-42 142.3 0.3 1.4 2 0 0 2 2 2 1 Ribosomal protein S11 DUF814 PF05670.8 CDI78927.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF814) DUF3720 PF12517.3 CDI78927.1 - 1.8 9.3 11.4 0.47 11.1 5.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3720) PI3_PI4_kinase PF00454.22 CDI78929.1 - 2.6e-17 63.0 0.0 6.4e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 CDI78929.1 - 9.4e-15 53.7 0.0 2.2e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 FATC domain Peptidase_A22B PF04258.8 CDI78931.1 - 1.1e-61 208.9 8.4 1.8e-61 208.2 5.8 1.3 1 0 0 1 1 1 1 Signal peptide peptidase DUF1119 PF06550.6 CDI78931.1 - 2.1 7.4 21.1 0.64 9.0 9.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1119) HEAT PF02985.17 CDI78932.1 - 4.4e-14 51.2 13.2 0.00026 20.8 0.3 6.1 5 0 0 5 5 5 3 HEAT repeat Pkinase PF00069.20 CDI78932.1 - 0.00056 19.1 0.0 0.00056 19.1 0.0 3.1 4 0 0 4 4 4 1 Protein kinase domain Mem_trans PF03547.13 CDI78932.1 - 0.0014 16.9 0.1 0.0014 16.9 0.1 3.9 4 0 0 4 4 4 2 Membrane transport protein Mito_fiss_reg PF05308.6 CDI78934.1 - 7.4 5.8 9.5 8.9 5.5 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator His_Phos_2 PF00328.17 CDI78935.1 - 4.3e-29 101.9 10.9 2.4e-22 79.7 0.1 7.0 5 2 2 7 7 7 3 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 CDI78935.1 - 8.9e-05 22.0 0.0 0.0003 20.3 0.0 1.9 1 0 0 1 1 1 1 RimK-like ATP-grasp domain EamA PF00892.15 CDI78937.1 - 0.0015 18.5 18.4 0.011 15.7 3.1 3.1 2 0 0 2 2 2 2 EamA-like transporter family D123 PF07065.9 CDI78938.1 - 2.5e-12 46.5 0.0 2.7e-11 43.1 0.0 5.3 4 2 0 4 4 4 2 D123 Suf PF05843.9 CDI78938.1 - 0.0014 18.3 20.4 0.0014 18.3 14.1 4.9 5 0 0 5 5 5 2 Suppressor of forked protein (Suf) DUF3306 PF11748.3 CDI78938.1 - 0.0019 18.8 0.4 0.0019 18.8 0.3 7.7 7 1 0 7 7 7 1 Protein of unknown function (DUF3306) Spore_coat_CotO PF14153.1 CDI78938.1 - 0.0047 16.3 26.7 0.0047 16.3 18.5 4.9 5 0 0 5 5 5 1 Spore coat protein CotO Dehydrin PF00257.14 CDI78938.1 - 1 9.6 53.0 1 9.6 0.0 6.3 5 2 0 5 5 5 0 Dehydrin SAPS PF04499.10 CDI78938.1 - 1.8 7.0 31.6 4.4 5.8 0.0 3.4 3 1 0 3 3 3 0 SIT4 phosphatase-associated protein Rtf2 PF04641.7 CDI78938.1 - 2 7.5 37.7 0.49 9.5 11.6 4.5 4 0 0 4 4 4 0 Rtf2 RING-finger DDHD PF02862.12 CDI78938.1 - 9.2 5.9 42.8 4.5 7.0 0.6 4.7 4 0 0 4 4 4 0 DDHD domain RRM_1 PF00076.17 CDI78939.1 - 1.1e-25 89.0 0.3 4.6e-12 45.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI78939.1 - 2.6e-21 75.3 0.0 9e-10 38.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI78939.1 - 0.0036 17.0 1.6 0.49 10.2 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 CDI78940.1 - 6.4e-07 28.9 10.1 1.9e-06 27.4 7.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FHA PF00498.21 CDI78940.1 - 1.1e-06 28.6 0.0 6.8e-06 26.1 0.0 2.3 2 0 0 2 2 2 1 FHA domain zf-C3HC4_2 PF13923.1 CDI78940.1 - 1.3e-06 28.3 14.9 3.8e-06 26.8 10.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI78940.1 - 2e-06 27.5 13.6 6.4e-06 25.8 9.4 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 CDI78940.1 - 2.7e-06 27.1 14.9 2.7e-06 27.1 10.3 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 CDI78940.1 - 1.1e-05 25.0 13.7 2.8e-05 23.6 9.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Med15 PF09606.5 CDI78940.1 - 6e-05 21.4 26.1 6e-05 21.4 18.1 6.8 5 3 2 7 7 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal zf-RING_UBOX PF13445.1 CDI78940.1 - 0.00071 19.2 9.5 0.0023 17.6 6.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 CDI78940.1 - 0.0012 18.4 12.6 0.0039 16.8 8.7 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 CDI78940.1 - 0.0059 16.6 4.0 0.019 15.0 2.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_4 PF14570.1 CDI78940.1 - 0.0072 15.8 2.9 0.0072 15.8 2.0 1.9 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain U-box PF04564.10 CDI78940.1 - 0.059 13.3 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-Nse PF11789.3 CDI78940.1 - 0.32 10.5 5.7 0.72 9.4 4.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.9 CDI78940.1 - 0.58 9.6 2.8 0.25 10.8 0.1 1.7 2 0 0 2 2 2 0 Rad50 zinc hook motif LMBR1 PF04791.11 CDI78940.1 - 7.1 5.0 10.1 0.18 10.3 2.0 1.9 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF3223 PF11523.3 CDI78941.1 - 2.9e-10 40.3 0.5 8e-10 38.8 0.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) La PF05383.12 CDI78941.1 - 2.2e-09 36.9 0.0 5.4e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 La domain GSK-3_bind PF05350.7 CDI78942.1 - 0.11 11.9 5.0 0.16 11.4 3.5 1.2 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding Med3 PF11593.3 CDI78942.1 - 0.69 9.0 9.7 0.99 8.5 6.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Suf PF05843.9 CDI78943.1 - 0.015 15.0 4.5 0.015 15.0 3.1 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PsaN PF05479.6 CDI78943.1 - 0.018 15.0 2.7 0.024 14.6 1.9 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Herpes_UL43 PF05072.8 CDI78943.1 - 0.023 13.4 7.3 0.034 12.9 4.8 1.7 1 1 0 1 1 1 0 Herpesvirus UL43 protein TraT PF05818.7 CDI78943.1 - 0.035 13.5 0.9 0.046 13.1 0.6 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Spore_coat_CotO PF14153.1 CDI78943.1 - 0.44 9.9 6.6 0.53 9.6 4.6 1.1 1 0 0 1 1 1 0 Spore coat protein CotO UPF0560 PF10577.4 CDI78943.1 - 0.48 8.6 7.0 0.55 8.4 4.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2749 PF10907.3 CDI78943.1 - 0.79 9.6 3.0 15 5.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Shadoo PF14999.1 CDI78943.1 - 1.9 8.3 14.6 2.5 7.9 0.0 2.1 1 1 1 2 2 2 0 Shadow of prion protein, neuroprotective PAT1 PF09770.4 CDI78943.1 - 2.4 6.2 19.0 2.5 6.2 13.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI78943.1 - 3.5 5.7 22.6 4.1 5.4 15.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal zf-rbx1 PF12678.2 CDI78944.1 - 4e-07 30.0 1.7 4e-07 30.0 1.2 1.6 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CDI78944.1 - 5.4e-07 29.3 5.7 5.4e-07 29.3 4.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-Apc11 PF12861.2 CDI78944.1 - 0.00014 21.6 0.6 0.00028 20.6 0.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 CDI78944.1 - 0.00061 19.3 0.9 0.0013 18.3 0.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI78944.1 - 0.0028 17.3 2.0 0.0071 16.0 1.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDI78944.1 - 0.013 15.5 4.6 0.029 14.3 3.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PGAP1 PF07819.8 CDI78946.1 - 1.8e-11 44.0 0.1 4.7e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 PGAP1-like protein CDK2AP PF09806.4 CDI78946.1 - 0.0034 17.6 3.7 0.0034 17.6 2.6 15.4 11 5 1 13 13 13 2 Cyclin-dependent kinase 2-associated protein SAPS PF04499.10 CDI78946.1 - 0.035 12.7 0.0 0.035 12.7 0.0 4.8 4 2 0 4 4 4 0 SIT4 phosphatase-associated protein DAP10 PF07213.6 CDI78947.1 - 0.051 13.3 1.9 2.4 7.9 0.0 2.8 3 0 0 3 3 3 0 DAP10 membrane protein Chorismate_synt PF01264.16 CDI78950.1 - 1.7e-59 201.0 0.0 1.2e-42 145.6 0.0 2.2 1 1 1 2 2 2 2 Chorismate synthase DUF4349 PF14257.1 CDI78950.1 - 8.4 5.5 17.6 5 6.2 8.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Herpes_TAF50 PF03326.8 CDI78951.1 - 2.2 7.1 42.0 0.1 11.5 24.7 1.7 1 1 1 2 2 2 0 Herpesvirus transcription activation factor (transactivator) Amino_oxidase PF01593.19 CDI78951.1 - 4.3 6.2 12.2 0.46 9.4 3.5 2.0 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase PAM2 PF07145.10 CDI78952.1 - 1.6e-05 24.0 1.0 3.9e-05 22.8 0.7 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region N6_N4_Mtase PF01555.13 CDI78952.1 - 0.0032 16.9 0.0 63 2.9 5.7 3.2 4 2 0 5 5 5 1 DNA methylase Rad4 PF03835.10 CDI78957.1 - 1.1e-06 28.1 12.6 2.8e-06 26.7 0.0 4.1 3 0 0 3 3 3 2 Rad4 transglutaminase-like domain BHD_3 PF10405.4 CDI78957.1 - 7.6e-06 25.5 0.0 2.9e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 Rad4 beta-hairpin domain 3 RAP PF08373.5 CDI78958.1 - 0.00032 20.4 0.0 0.001 18.8 0.0 1.9 1 0 0 1 1 1 1 RAP domain Sec63 PF02889.11 CDI78959.1 - 7.9e-120 399.8 0.0 4e-46 157.6 0.0 3.9 2 2 1 3 3 3 3 Sec63 Brl domain DEAD PF00270.24 CDI78959.1 - 8.5e-19 67.6 0.1 1e-09 38.1 0.0 2.9 2 0 0 2 2 2 2 DEAD/DEAH box helicase UPF0086 PF01868.11 CDI78959.1 - 1.4e-07 31.0 0.0 3e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Helicase_C PF00271.26 CDI78959.1 - 1.2e-05 25.0 0.0 1.2e-05 25.0 0.0 4.2 6 0 0 6 6 6 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDI78959.1 - 0.00067 19.8 0.2 1.5 8.9 0.0 4.0 2 1 0 2 2 2 2 AAA domain DNA_ligase_A_C PF04679.10 CDI78959.1 - 0.0082 16.5 1.4 9.2 6.7 0.0 3.6 2 0 0 2 2 2 2 ATP dependent DNA ligase C terminal region Arrestin_N PF00339.24 CDI78961.1 - 1.2 8.9 7.6 0.076 12.8 1.4 1.8 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Methyltransf_15 PF09445.5 CDI78962.1 - 1.2e-10 41.2 1.3 7.8e-06 25.5 0.0 2.9 3 0 0 3 3 3 2 RNA cap guanine-N2 methyltransferase Spt20 PF12090.3 CDI78962.1 - 0.18 11.1 12.8 0.59 9.4 2.9 2.3 2 0 0 2 2 2 0 Spt20 family zf-DHHC PF01529.15 CDI78962.1 - 0.6 9.4 3.6 5.1 6.4 1.9 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase Ctr PF04145.10 CDI78962.1 - 7.8 6.5 12.4 2.8 7.9 1.3 3.3 4 0 0 4 4 4 0 Ctr copper transporter family AMA-1 PF02430.10 CDI78963.1 - 3.8e-06 26.0 0.0 4.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Apical membrane antigen 1 ETRAMP PF09716.5 CDI78963.1 - 0.022 14.7 0.3 0.061 13.2 0.1 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Herpes_gE PF02480.11 CDI78963.1 - 0.05 11.8 0.0 0.074 11.3 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF1191 PF06697.7 CDI78963.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) DUF3042 PF11240.3 CDI78963.1 - 0.14 11.9 0.8 0.37 10.6 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) COX2 PF00116.15 CDI78964.1 - 0.063 13.1 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain AMP-binding PF00501.23 CDI78967.1 - 5.5e-12 44.8 0.9 3.3e-06 25.7 0.0 3.2 4 0 0 4 4 4 2 AMP-binding enzyme tRNA-synt_2b PF00587.20 CDI78968.1 - 9.3e-09 35.0 0.0 1.5e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ADK_lid PF05191.9 CDI78968.1 - 0.13 11.9 0.0 1.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Adenylate kinase, active site lid WD40 PF00400.27 CDI78969.1 - 8.5e-10 38.1 1.8 2.4e-06 27.2 0.3 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat DHC_N1 PF08385.7 CDI78970.1 - 5.1e-84 282.6 3.4 5.1e-84 282.6 2.4 3.4 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 Dynein_heavy PF03028.10 CDI78971.1 - 8.6e-149 496.7 0.0 2.8e-77 260.3 0.0 3.5 1 1 2 3 3 3 3 Dynein heavy chain and region D6 of dynein motor AAA_6 PF12774.2 CDI78971.1 - 8.6e-96 319.9 0.1 1.5e-95 319.1 0.1 1.4 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N2 PF08393.8 CDI78971.1 - 7.1e-81 271.7 6.2 9.9e-73 244.9 1.4 3.3 3 0 0 3 3 3 2 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.2 CDI78971.1 - 4.7e-54 183.1 0.0 9.6e-54 182.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 CDI78971.1 - 5.9e-52 176.5 9.7 9.2e-52 175.8 6.7 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 CDI78971.1 - 1.1e-50 172.2 0.0 8.1e-49 166.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_9 PF12781.2 CDI78971.1 - 2e-29 102.0 0.2 1e-24 86.6 0.0 2.4 1 1 1 2 2 2 2 ATP-binding dynein motor region D5 AAA_5 PF07728.9 CDI78971.1 - 3.3e-22 78.7 0.0 3.2e-05 23.6 0.0 5.9 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDI78971.1 - 8.7e-07 29.1 0.5 0.82 9.8 0.0 4.7 4 0 0 4 4 4 1 AAA domain AAA PF00004.24 CDI78971.1 - 2.6e-05 24.4 1.2 0.16 12.1 0.0 4.7 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDI78971.1 - 3e-05 24.8 0.1 2.1 9.1 0.0 4.7 3 0 0 3 3 3 2 AAA domain Sigma54_activat PF00158.21 CDI78971.1 - 0.0062 16.0 0.0 5.2 6.5 0.0 3.2 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_19 PF13245.1 CDI78971.1 - 0.0063 16.2 2.3 0.8 9.4 0.1 3.3 3 0 0 3 3 3 1 Part of AAA domain Reo_sigmaC PF04582.7 CDI78971.1 - 0.0097 15.1 3.5 0.71 8.9 0.8 2.4 2 0 0 2 2 2 1 Reovirus sigma C capsid protein FtsK_SpoIIIE PF01580.13 CDI78971.1 - 0.039 13.4 6.3 0.36 10.2 0.0 4.1 4 0 0 4 4 4 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 CDI78971.1 - 0.062 13.4 0.0 15 5.8 0.0 3.5 3 0 0 3 3 3 0 RNA helicase DUF258 PF03193.11 CDI78971.1 - 0.11 11.7 0.2 0.79 8.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 CDI78971.1 - 0.31 10.3 6.3 6.8 6.0 0.0 4.4 5 0 0 5 5 5 0 AAA domain AAA_18 PF13238.1 CDI78971.1 - 0.52 10.6 8.8 3.8 7.8 0.0 4.3 5 0 0 5 5 3 0 AAA domain Atg14 PF10186.4 CDI78971.1 - 2.6 6.8 22.5 1.1 8.1 4.6 2.4 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 CDI78971.1 - 6.1 5.7 19.2 0.5 9.3 3.0 2.5 2 0 0 2 2 2 0 Autophagy protein Apg6 AAA_28 PF13521.1 CDI78971.1 - 8.9 6.2 10.8 1.7 8.6 0.0 3.4 4 0 0 4 4 3 0 AAA domain Ran_BP1 PF00638.13 CDI78972.1 - 1.2e-37 128.7 3.1 1.2e-37 128.7 2.1 1.7 2 0 0 2 2 2 1 RanBP1 domain WH1 PF00568.18 CDI78972.1 - 0.011 15.3 3.2 0.044 13.5 2.2 1.8 1 1 0 1 1 1 0 WH1 domain Mucin PF01456.12 CDI78972.1 - 1.1 8.9 6.7 0.074 12.8 1.4 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein APS-reductase_C PF12139.3 CDI78972.1 - 1.6 8.9 4.2 11 6.2 2.9 2.4 1 1 0 1 1 1 0 Adenosine-5'-phosphosulfate reductase beta subunit NAD_binding_11 PF14833.1 CDI78973.1 - 1e-31 109.5 0.0 1e-31 109.5 0.0 2.2 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.10 CDI78973.1 - 1.5e-23 83.4 1.6 5.7e-09 36.0 0.0 3.3 1 1 2 3 3 3 3 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 CDI78973.1 - 6.8e-05 23.2 1.1 0.15 12.5 0.1 2.6 1 1 1 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 CDI78973.1 - 0.013 15.1 0.2 0.031 13.9 0.1 1.7 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF4154 PF13689.1 CDI78973.1 - 0.033 13.8 0.5 0.056 13.0 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4154) UDPG_MGDP_dh_N PF03721.9 CDI78973.1 - 0.081 12.2 0.1 1.7 7.9 0.0 2.3 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF572 PF04502.8 CDI78974.1 - 8.8 5.4 28.4 13 4.8 19.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Auto_anti-p27 PF06677.7 CDI78975.1 - 9.2e-11 41.3 0.4 1.6e-10 40.5 0.3 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TFIIA PF03153.8 CDI78975.1 - 0.51 10.1 40.6 0.67 9.7 28.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PBP1_TM PF14812.1 CDI78975.1 - 0.71 10.2 13.1 1.3 9.3 2.1 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spore_YhcN_YlaJ PF09580.5 CDI78975.1 - 2.4 8.2 17.3 5.1 7.1 4.5 2.3 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF3537 PF12056.3 CDI78975.1 - 4.7 5.8 10.5 1.7 7.2 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) FLO_LFY PF01698.11 CDI78975.1 - 5.4 5.7 25.2 1.1 8.0 2.8 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein PLRV_ORF5 PF01690.12 CDI78975.1 - 7.4 5.6 21.4 11 5.0 14.8 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein AP2 PF00847.15 CDI78976.1 - 1.2e-07 31.7 0.1 1.2e-07 31.7 0.1 3.8 4 0 0 4 4 4 1 AP2 domain Atg14 PF10186.4 CDI78977.1 - 7.9 5.3 30.5 0.75 8.6 15.6 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 T2SF PF00482.18 CDI78977.1 - 9.2 6.1 8.8 31 4.5 2.6 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Spt20 PF12090.3 CDI78979.1 - 0.018 14.4 0.6 0.023 14.0 0.4 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.9 CDI78979.1 - 0.02 14.6 3.0 0.024 14.3 2.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CagX PF03524.10 CDI78979.1 - 0.069 12.4 0.4 0.13 11.5 0.2 1.4 1 0 0 1 1 1 0 Conjugal transfer protein FimP PF09766.4 CDI78979.1 - 0.33 9.9 8.0 0.47 9.4 5.6 1.1 1 0 0 1 1 1 0 Fms-interacting protein Peptidase_S49_N PF08496.5 CDI78979.1 - 0.58 9.9 3.1 0.91 9.3 2.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RAB3GAP2_N PF14655.1 CDI78979.1 - 5 6.0 6.1 7.8 5.3 4.2 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Tox-WTIP PF15654.1 CDI78981.1 - 1.3 8.7 4.4 17 5.0 0.0 2.6 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif ubiquitin PF00240.18 CDI78983.1 - 9.1e-07 28.1 0.1 2.2e-06 26.9 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 CDI78983.1 - 2e-05 24.7 0.0 7.3e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.3 CDI78983.1 - 0.016 14.8 0.1 0.065 12.9 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PI3K_rbd PF00794.13 CDI78983.1 - 0.098 12.6 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain WD40 PF00400.27 CDI78986.1 - 3.7e-30 102.6 23.6 5.9e-09 35.4 0.0 7.9 7 1 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.6 CDI78986.1 - 1.2e-10 40.4 1.0 3e-10 39.1 0.7 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like DUF4632 PF15451.1 CDI78987.1 - 0.22 11.4 0.1 0.22 11.4 0.0 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4632) WD40 PF00400.27 CDI78988.1 - 3.9e-13 48.7 4.2 4e-06 26.5 0.0 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Bromodomain PF00439.20 CDI78988.1 - 3.9e-07 29.8 0.0 7.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Citrate_synt PF00285.16 CDI78989.1 - 1.6e-24 86.3 0.0 5.5e-22 77.9 0.0 3.1 2 1 1 3 3 3 2 Citrate synthase Ligase_CoA PF00549.14 CDI78989.1 - 1.5e-06 27.8 0.0 5.5e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 CoA-ligase DUF3441 PF11923.3 CDI78990.1 - 1.7e-18 66.2 0.9 7e-17 61.0 0.0 4.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 CDI78990.1 - 2.2e-18 65.9 7.2 8.3e-17 60.8 0.3 4.2 2 1 0 2 2 2 1 Domain of unknown function (DUF814) FbpA PF05833.6 CDI78990.1 - 1.5e-14 53.4 13.7 4.1e-13 48.6 0.1 9.1 7 3 2 9 9 9 2 Fibronectin-binding protein A N-terminus (FbpA) Frizzled PF01534.12 CDI78991.1 - 0.12 11.1 0.1 0.12 11.1 0.0 2.7 2 1 0 2 2 2 0 Frizzled/Smoothened family membrane region Saccharop_dh PF03435.13 CDI78992.1 - 1.7e-13 50.3 0.1 2.4e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase adh_short PF00106.20 CDI78992.1 - 0.053 13.4 0.1 5.4 6.9 0.0 2.3 2 0 0 2 2 2 0 short chain dehydrogenase Pox_MCEL PF03291.11 CDI78994.1 - 2.2e-25 89.2 0.1 8.3e-25 87.3 0.0 1.7 2 0 0 2 2 2 1 mRNA capping enzyme Methyltransf_31 PF13847.1 CDI78994.1 - 1.6e-10 40.8 0.6 3.6e-10 39.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI78994.1 - 4.4e-09 36.9 0.0 4.4e-09 36.9 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI78994.1 - 6.8e-08 32.9 0.8 2.2e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI78994.1 - 9e-08 32.5 0.3 1.2e-06 28.9 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI78994.1 - 3.1e-06 26.9 0.2 8.4e-05 22.3 0.0 3.1 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI78994.1 - 3.7e-06 27.2 0.0 1.6e-05 25.1 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI78994.1 - 6.6e-05 22.9 0.0 6.6e-05 22.9 0.0 4.9 3 2 0 4 4 3 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDI78994.1 - 0.0012 18.0 0.0 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 CDI78994.1 - 0.0014 17.8 0.0 0.0014 17.8 0.0 2.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase MetW PF07021.7 CDI78994.1 - 0.0061 15.9 0.1 0.015 14.6 0.0 1.6 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Reprolysin_3 PF13582.1 CDI78995.1 - 0.59 10.6 0.0 0.59 10.6 0.0 3.2 4 0 0 4 4 4 0 Metallo-peptidase family M12B Reprolysin-like SGT1 PF07093.6 CDI78995.1 - 0.87 7.8 7.3 0.037 12.4 0.6 1.9 2 0 0 2 2 2 0 SGT1 protein SDA1 PF05285.7 CDI78995.1 - 2.6 7.2 8.7 0.69 9.1 0.2 2.3 2 0 0 2 2 2 0 SDA1 DUF241 PF03087.9 CDI78995.1 - 2.6 7.4 12.9 3.8 6.9 2.9 2.7 3 0 0 3 3 3 0 Arabidopsis protein of unknown function PFK PF00365.15 CDI78996.1 - 3.4e-22 78.7 7.2 7.7e-18 64.4 0.1 3.8 4 1 0 4 4 4 2 Phosphofructokinase Methyltransf_2 PF00891.13 CDI78996.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Activator_LAG-3 PF11498.3 CDI78996.1 - 5.9 5.5 14.9 11 4.6 10.3 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 zf-CCCH PF00642.19 CDI78997.1 - 0.0071 16.0 2.8 0.0071 16.0 2.0 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Afi1 PF07792.7 CDI78997.1 - 2.3 8.2 21.0 1.5 8.8 6.5 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Band_3_cyto PF07565.8 CDI78997.1 - 3.3 7.1 24.9 2 7.8 10.3 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain AAA_12 PF13087.1 CDI78999.1 - 2.5e-33 115.1 0.0 5.2e-33 114.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CDI78999.1 - 2.6e-18 66.4 0.0 6.6e-08 32.4 0.0 3.2 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.1 CDI78999.1 - 1e-08 35.0 0.0 4e-08 33.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDI78999.1 - 4.6e-08 32.7 0.8 2.4e-07 30.4 0.2 2.5 2 0 0 2 2 2 1 Part of AAA domain Viral_helicase1 PF01443.13 CDI78999.1 - 2.5e-07 30.4 0.1 0.3 10.5 0.0 3.5 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 CDI78999.1 - 0.0073 16.4 0.1 0.035 14.2 0.0 2.3 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain Tmemb_cc2 PF10267.4 CDI79000.1 - 0.29 9.6 7.7 0.39 9.2 5.3 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein KAR9 PF08580.5 CDI79000.1 - 5.7 5.0 11.4 6.1 4.9 7.9 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Peptidase_S64 PF08192.6 CDI79000.1 - 8.4 4.5 8.8 9.9 4.3 6.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4342 PF14242.1 CDI79001.1 - 0.0097 15.6 0.0 0.0097 15.6 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4342) LMBR1 PF04791.11 CDI79001.1 - 0.66 8.4 0.0 0.66 8.4 0.0 4.6 3 1 2 5 5 5 0 LMBR1-like membrane protein Hydrolase PF00702.21 CDI79003.1 - 9.8e-05 22.8 0.0 9.8e-05 22.8 0.0 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase IncA PF04156.9 CDI79004.1 - 5.7e-05 22.7 12.1 5.7e-05 22.7 8.4 2.2 1 1 1 2 2 2 1 IncA protein Cyto_ox_2 PF02322.10 CDI79004.1 - 0.0096 15.1 9.6 0.014 14.6 6.6 1.2 1 0 0 1 1 1 1 Cytochrome oxidase subunit II DUF2232 PF09991.4 CDI79004.1 - 0.085 11.8 2.0 0.14 11.1 1.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Med15 PF09606.5 CDI79004.1 - 7.5 4.6 64.9 0.44 8.6 41.3 1.5 1 1 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SelP_N PF04592.9 CDI79006.1 - 0.008 15.5 10.8 0.008 15.5 7.5 2.1 2 0 0 2 2 2 1 Selenoprotein P, N terminal region Ycf1 PF05758.7 CDI79006.1 - 1.1 6.9 13.0 1.9 6.0 8.4 1.8 2 0 0 2 2 2 0 Ycf1 Raftlin PF15250.1 CDI79007.1 - 0.0048 15.4 3.0 0.0058 15.2 2.1 1.1 1 0 0 1 1 1 1 Raftlin FLO_LFY PF01698.11 CDI79007.1 - 0.012 14.4 4.9 0.015 14.1 3.4 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein PAT1 PF09770.4 CDI79007.1 - 0.018 13.3 20.4 0.021 13.1 14.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.9 CDI79007.1 - 0.023 12.7 7.2 0.034 12.1 5.0 1.2 1 0 0 1 1 1 0 CDC45-like protein ETRAMP PF09716.5 CDI79007.1 - 0.069 13.1 10.3 0.59 10.1 0.0 3.4 2 1 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Baculo_PP31 PF05311.6 CDI79007.1 - 0.34 10.1 6.6 0.49 9.6 4.6 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF3260 PF11658.3 CDI79007.1 - 0.35 8.9 5.8 0.5 8.4 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) PBP1_TM PF14812.1 CDI79007.1 - 0.65 10.3 7.1 1.4 9.3 5.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Med15 PF09606.5 CDI79007.1 - 1 7.4 38.9 0.037 12.2 22.1 1.8 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF-3_zeta PF05091.7 CDI79007.1 - 1 7.8 15.8 1.4 7.4 11.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2126 PF09899.4 CDI79007.1 - 1 7.2 7.1 1.5 6.7 4.9 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Pex16 PF08610.5 CDI79007.1 - 1.2 8.0 5.9 2 7.3 4.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) FAM176 PF14851.1 CDI79007.1 - 2.8 7.6 6.8 48 3.6 4.1 2.2 2 0 0 2 2 2 0 FAM176 family OATP PF03137.15 CDI79007.1 - 6.7 4.6 6.5 12 3.8 4.5 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_transf_15 PF01793.11 CDI79007.1 - 8.6 5.2 11.0 12 4.6 7.6 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase SpoVR PF04293.8 CDI79007.1 - 9.9 4.3 12.8 15 3.8 8.9 1.1 1 0 0 1 1 1 0 SpoVR like protein DUF2407 PF10302.4 CDI79008.1 - 0.024 14.7 7.0 0.048 13.8 0.0 3.4 3 0 0 3 3 3 0 DUF2407 ubiquitin-like domain Neisseria_PilC PF05567.6 CDI79008.1 - 0.11 11.4 0.3 0.21 10.6 0.2 1.5 1 0 0 1 1 1 0 Neisseria PilC beta-propeller domain AMP-binding PF00501.23 CDI79008.1 - 1.3 7.3 8.0 0.19 10.0 2.0 2.0 2 0 0 2 2 2 0 AMP-binding enzyme RabGAP-TBC PF00566.13 CDI79010.1 - 1.6e-39 135.6 5.0 1.6e-39 135.6 3.5 3.0 4 0 0 4 4 4 1 Rab-GTPase-TBC domain IncA PF04156.9 CDI79011.1 - 0.004 16.7 8.1 0.004 16.7 5.6 3.6 2 1 1 3 3 3 2 IncA protein DUF4367 PF14285.1 CDI79011.1 - 0.048 12.9 0.3 1.5 8.1 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) EphA2_TM PF14575.1 CDI79011.1 - 0.071 13.5 15.8 0.25 11.7 0.1 4.6 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain DUF4179 PF13786.1 CDI79011.1 - 3.6 7.8 6.1 4.8 7.4 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) DUF2749 PF10907.3 CDI79011.1 - 5.2 7.0 8.5 12 5.8 2.0 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Med15 PF09606.5 CDI79011.1 - 8.6 4.4 95.4 0.028 12.6 36.9 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal HSP90 PF00183.13 CDI79012.1 - 4.4e-06 25.3 0.0 4.6e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Hsp90 protein DNMT1-RFD PF12047.3 CDI79013.1 - 1.3e-06 28.2 0.0 3.4e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain Auxin_resp PF06507.8 CDI79013.1 - 0.00016 21.4 0.0 0.00042 20.1 0.0 1.7 1 0 0 1 1 1 1 Auxin response factor DUF4013 PF13197.1 CDI79013.1 - 2.6 7.3 0.8 5.2 6.3 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) HECT PF00632.20 CDI79014.1 - 1.9e-20 73.2 0.0 2.1e-20 73.1 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) MarC PF01914.12 CDI79015.1 - 0.2 10.7 0.3 1.8 7.5 0.2 2.8 1 0 0 1 1 1 0 MarC family integral membrane protein IQ PF00612.22 CDI79016.1 - 0.00022 20.5 21.0 0.0054 16.2 0.4 4.3 3 0 0 3 3 3 3 IQ calmodulin-binding motif Myosin_head PF00063.16 CDI79018.1 - 2.4e-27 95.3 1.1 5.7e-21 74.2 0.0 2.7 2 2 0 2 2 2 2 Myosin head (motor domain) Rtf2 PF04641.7 CDI79018.1 - 0.0097 15.1 2.1 0.13 11.4 0.2 2.2 2 0 0 2 2 2 1 Rtf2 RING-finger Pex14_N PF04695.8 CDI79018.1 - 0.027 14.5 0.6 0.027 14.5 0.4 2.8 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.9 CDI79018.1 - 0.033 13.9 8.5 0.48 10.1 2.9 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF2722 PF10846.3 CDI79018.1 - 0.053 12.5 10.8 0.12 11.3 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) zf-DHHC PF01529.15 CDI79018.1 - 0.08 12.3 2.7 8.4 5.7 0.0 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase Band_3_cyto PF07565.8 CDI79018.1 - 0.13 11.7 4.6 0.42 10.0 0.6 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain AAA_23 PF13476.1 CDI79018.1 - 0.16 12.2 10.6 0.22 11.8 2.4 2.2 2 0 0 2 2 2 0 AAA domain Spore_coat_CotO PF14153.1 CDI79018.1 - 0.18 11.2 12.1 0.086 12.2 2.5 2.2 2 0 0 2 2 2 0 Spore coat protein CotO DUF3886 PF13025.1 CDI79018.1 - 0.2 11.6 19.5 0.5 10.3 6.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) DUF3899 PF13038.1 CDI79018.1 - 0.22 11.6 0.3 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DnaJ-X PF14308.1 CDI79018.1 - 0.27 10.4 10.9 0.047 12.9 1.5 2.2 2 0 0 2 2 2 0 X-domain of DnaJ-containing DUF912 PF06024.7 CDI79018.1 - 0.32 11.0 4.4 0.81 9.7 0.3 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Presenilin PF01080.12 CDI79018.1 - 0.38 9.5 0.0 0.38 9.5 0.0 2.2 2 1 1 3 3 3 0 Presenilin DUF3371 PF11851.3 CDI79018.1 - 0.38 11.4 12.7 3.6 8.2 4.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) DUF3464 PF11947.3 CDI79018.1 - 0.42 10.0 2.9 3.3 7.1 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3464) DIT1_PvcA PF05141.7 CDI79018.1 - 0.53 9.5 4.2 0.35 10.1 0.0 2.5 3 0 0 3 3 3 0 Pyoverdine/dityrosine biosynthesis protein RIC3 PF15361.1 CDI79018.1 - 0.55 10.4 9.8 6.6 6.9 2.0 3.1 3 0 0 3 3 3 0 Resistance to inhibitors of cholinesterase homologue 3 FimP PF09766.4 CDI79018.1 - 1.2 8.1 18.8 2.1 7.3 7.9 2.2 2 0 0 2 2 2 0 Fms-interacting protein SKIP_SNW PF02731.10 CDI79018.1 - 1.3 8.4 14.0 0.7 9.3 3.8 2.3 2 0 0 2 2 2 0 SKIP/SNW domain Kin17_mid PF10357.4 CDI79018.1 - 1.8 8.2 13.5 0.14 11.8 3.2 2.2 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein Conotoxin PF02950.12 CDI79018.1 - 2.1 9.1 6.8 6.6 7.6 0.8 2.7 2 0 0 2 2 2 0 Conotoxin Med15 PF09606.5 CDI79018.1 - 3.4 5.7 37.8 0.0094 14.2 7.2 2.9 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal PEX11 PF05648.9 CDI79018.1 - 6.1 6.0 8.6 4 6.6 0.4 2.9 3 0 0 3 3 3 0 Peroxisomal biogenesis factor 11 (PEX11) PHD_3 PF13922.1 CDI79018.1 - 6.9 6.9 17.3 3.8 7.8 3.4 2.7 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx ATAD4 PF15321.1 CDI79018.1 - 7.5 7.6 10.0 40 5.2 4.0 2.4 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 RAB3GAP2_N PF14655.1 CDI79018.1 - 8.5 5.2 16.6 0.54 9.2 0.5 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1764 PF08576.5 CDI79018.1 - 8.9 7.1 13.6 6.7 7.5 4.3 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) IF-2B PF01008.12 CDI79022.1 - 4.9e-12 45.4 2.6 1.2e-11 44.1 1.8 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Suf PF05843.9 CDI79022.1 - 0.0026 17.5 8.3 0.0028 17.4 5.8 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) FLO_LFY PF01698.11 CDI79022.1 - 0.0027 16.6 4.0 0.0029 16.5 2.8 1.1 1 0 0 1 1 1 1 Floricaula / Leafy protein RskA PF10099.4 CDI79022.1 - 0.0055 16.4 3.5 0.0083 15.8 2.4 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Zip PF02535.17 CDI79022.1 - 0.01 14.8 15.9 0.015 14.2 11.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SPX PF03105.14 CDI79022.1 - 0.014 15.1 4.3 0.016 15.0 3.0 1.1 1 0 0 1 1 1 0 SPX domain SelP_N PF04592.9 CDI79022.1 - 0.022 14.1 28.5 0.029 13.7 19.7 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CDK5_activator PF03261.10 CDI79022.1 - 0.028 13.7 9.1 0.032 13.5 6.3 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SprA-related PF12118.3 CDI79022.1 - 0.04 13.2 27.8 0.05 12.9 19.3 1.1 1 0 0 1 1 1 0 SprA-related family CMV_1a PF12467.3 CDI79022.1 - 0.07 13.5 5.1 0.093 13.1 3.6 1.1 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family DUF4220 PF13968.1 CDI79022.1 - 0.081 12.0 1.1 0.078 12.0 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) MARCKS PF02063.12 CDI79022.1 - 0.096 12.5 10.2 0.12 12.2 7.1 1.1 1 0 0 1 1 1 0 MARCKS family PAT1 PF09770.4 CDI79022.1 - 0.11 10.6 29.3 0.13 10.4 20.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2215 PF10225.4 CDI79022.1 - 0.12 11.8 2.1 0.14 11.5 1.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) eIF-3_zeta PF05091.7 CDI79022.1 - 0.12 10.9 9.3 0.13 10.8 6.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.8 CDI79022.1 - 0.13 12.0 27.3 0.16 11.8 18.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.5 CDI79022.1 - 0.14 10.2 35.5 0.18 9.9 24.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RP-C_C PF11800.3 CDI79022.1 - 0.19 11.4 10.7 0.24 11.1 7.4 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region UPF0560 PF10577.4 CDI79022.1 - 0.19 9.9 16.5 0.26 9.5 11.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ycf1 PF05758.7 CDI79022.1 - 0.27 8.8 4.0 0.29 8.8 2.8 1.0 1 0 0 1 1 1 0 Ycf1 RR_TM4-6 PF06459.7 CDI79022.1 - 0.27 11.0 9.6 0.34 10.7 6.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF605 PF04652.11 CDI79022.1 - 0.28 10.5 17.9 0.31 10.3 12.4 1.1 1 0 0 1 1 1 0 Vta1 like Tim54 PF11711.3 CDI79022.1 - 0.3 9.6 4.8 0.36 9.3 3.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4045 PF13254.1 CDI79022.1 - 0.31 10.2 8.7 0.34 10.1 6.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Serinc PF03348.10 CDI79022.1 - 0.33 9.6 8.0 0.4 9.3 5.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Macoilin PF09726.4 CDI79022.1 - 0.34 9.1 17.6 0.42 8.8 12.2 1.1 1 0 0 1 1 1 0 Transmembrane protein Band_3_cyto PF07565.8 CDI79022.1 - 0.36 10.2 11.3 0.42 10.0 7.8 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Hid1 PF12722.2 CDI79022.1 - 0.37 8.4 10.3 0.39 8.3 7.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.11 CDI79022.1 - 0.56 10.0 8.1 0.68 9.7 5.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tetraspannin PF00335.15 CDI79022.1 - 0.67 9.1 2.7 0.79 8.9 1.9 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF4175 PF13779.1 CDI79022.1 - 0.72 7.4 27.9 0.85 7.2 19.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FimP PF09766.4 CDI79022.1 - 1.1 8.2 18.0 1.4 7.8 12.5 1.1 1 0 0 1 1 1 0 Fms-interacting protein Chorion_S16 PF05836.7 CDI79022.1 - 1.2 9.0 7.2 1.9 8.4 5.0 1.2 1 0 0 1 1 1 0 Chorion protein S16 Pox_Ag35 PF03286.9 CDI79022.1 - 1.3 8.5 6.9 1.6 8.2 4.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Spore_coat_CotO PF14153.1 CDI79022.1 - 1.3 8.4 15.5 1.6 8.1 10.8 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Folate_carrier PF01770.13 CDI79022.1 - 1.3 7.4 6.0 1.6 7.1 4.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier Peptidase_S49_N PF08496.5 CDI79022.1 - 1.3 8.8 9.9 1.8 8.3 6.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal R_equi_Vir PF05526.6 CDI79022.1 - 1.5 8.4 9.1 2.3 7.8 6.3 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Raftlin PF15250.1 CDI79022.1 - 1.5 7.2 13.0 1.8 6.9 9.0 1.1 1 0 0 1 1 1 0 Raftlin NicO PF03824.11 CDI79022.1 - 2.2 7.5 12.6 2.8 7.1 8.7 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein AUX_IAA PF02309.11 CDI79022.1 - 2.3 7.8 10.3 2.9 7.5 7.1 1.1 1 0 0 1 1 1 0 AUX/IAA family BTV_NS2 PF04514.7 CDI79022.1 - 2.3 6.9 6.5 2.9 6.6 4.5 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Adeno_PIX PF03955.9 CDI79022.1 - 3.2 8.3 10.1 5.5 7.5 7.0 1.4 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) DUF940 PF06082.6 CDI79022.1 - 3.4 6.1 8.8 4.1 5.8 6.1 1.0 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) ZYG-11_interact PF05884.7 CDI79022.1 - 3.4 6.6 7.9 4.1 6.3 5.5 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 Spc7_N PF15402.1 CDI79022.1 - 3.8 5.3 18.7 4.7 5.0 12.9 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF3984 PF13136.1 CDI79022.1 - 4.4 6.4 19.6 6.2 5.9 13.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Presenilin PF01080.12 CDI79022.1 - 4.6 5.9 8.7 5.5 5.7 6.0 1.1 1 0 0 1 1 1 0 Presenilin HemX PF04375.9 CDI79022.1 - 4.7 5.6 19.6 6.1 5.3 13.6 1.0 1 0 0 1 1 1 0 HemX CKAP2_C PF15297.1 CDI79022.1 - 4.8 5.9 13.1 6.1 5.5 9.1 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF2946 PF11162.3 CDI79022.1 - 5.6 7.2 34.1 2.7e+02 1.7 23.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2946) Otopetrin PF03189.8 CDI79022.1 - 6.6 5.6 8.9 7.8 5.3 6.2 1.1 1 0 0 1 1 1 0 Otopetrin WD40 PF00400.27 CDI79023.1 - 2.7e-08 33.3 18.9 0.0006 19.5 0.2 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat Ribosomal_60s PF00428.14 CDI79023.1 - 0.00017 21.9 8.6 0.00017 21.9 6.0 10.5 7 5 3 10 10 10 2 60s Acidic ribosomal protein BSP_II PF05432.6 CDI79023.1 - 8.4 5.5 12.6 0.64 9.2 0.1 3.8 4 0 0 4 4 4 0 Bone sialoprotein II (BSP-II) Activator_LAG-3 PF11498.3 CDI79024.1 - 2.7 6.6 131.2 0.2 10.3 16.4 3.2 3 0 0 3 3 3 0 Transcriptional activator LAG-3 Metal_resist PF13801.1 CDI79025.1 - 0.33 10.9 2.7 0.69 9.9 0.0 2.5 2 1 1 3 3 3 0 Heavy-metal resistance Sina PF03145.11 CDI79026.1 - 1.1e-18 67.6 3.6 1.1e-18 67.6 2.5 2.9 2 1 0 2 2 2 1 Seven in absentia protein family SR-25 PF10500.4 CDI79026.1 - 1.7e-06 27.6 8.2 1.7e-06 27.6 5.7 2.9 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein CDK2AP PF09806.4 CDI79026.1 - 0.0022 18.2 0.9 0.0022 18.2 0.6 5.0 3 2 1 4 4 4 1 Cyclin-dependent kinase 2-associated protein zf-C3HC4_2 PF13923.1 CDI79026.1 - 0.025 14.6 14.9 0.07 13.1 10.4 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.13 CDI79026.1 - 0.047 14.0 13.9 0.065 13.6 0.4 3.3 1 1 1 2 2 2 0 TRAF-type zinc finger Ribosomal_60s PF00428.14 CDI79026.1 - 0.054 13.8 0.0 0.054 13.8 0.0 6.0 4 1 0 4 4 4 0 60s Acidic ribosomal protein zf-H2C2_5 PF13909.1 CDI79026.1 - 2.8 8.3 9.3 10 6.6 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain PAP1 PF08601.5 CDI79028.1 - 6.8 6.2 9.2 36 3.8 5.9 2.0 1 1 0 1 1 1 0 Transcription factor PAP1 DUF2457 PF10446.4 CDI79029.1 - 0.0016 17.2 14.1 0.0016 17.2 9.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) RXT2_N PF08595.6 CDI79029.1 - 0.0079 16.0 6.4 0.0087 15.8 4.4 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal Nucleoplasmin PF03066.10 CDI79029.1 - 0.0087 15.5 11.0 0.0093 15.4 7.6 1.2 1 0 0 1 1 1 1 Nucleoplasmin DUF2722 PF10846.3 CDI79029.1 - 0.023 13.7 3.0 0.025 13.6 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CobT PF06213.7 CDI79029.1 - 0.049 12.7 7.4 0.043 12.9 5.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Vfa1 PF08432.5 CDI79029.1 - 0.062 13.3 5.6 0.061 13.3 3.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sporozoite_P67 PF05642.6 CDI79029.1 - 0.096 10.5 5.6 0.093 10.5 3.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4366 PF14283.1 CDI79029.1 - 0.11 11.9 3.9 0.11 11.9 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF1510 PF07423.6 CDI79029.1 - 0.13 11.6 5.2 0.12 11.7 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) BTV_NS2 PF04514.7 CDI79029.1 - 0.14 11.0 4.0 0.14 11.0 2.8 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Daxx PF03344.10 CDI79029.1 - 0.15 10.5 10.2 0.13 10.7 7.1 1.0 1 0 0 1 1 1 0 Daxx Family NOA36 PF06524.7 CDI79029.1 - 0.2 10.8 13.7 0.2 10.8 9.5 1.0 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.8 CDI79029.1 - 0.21 9.3 10.9 0.17 9.5 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.11 CDI79029.1 - 0.22 10.4 6.2 0.21 10.5 4.3 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.1 CDI79029.1 - 0.27 10.9 3.2 0.29 10.8 2.2 1.3 1 0 0 1 1 1 0 FAM176 family SspB PF04386.8 CDI79029.1 - 0.31 10.6 5.0 0.39 10.3 3.5 1.1 1 0 0 1 1 1 0 Stringent starvation protein B CDC45 PF02724.9 CDI79029.1 - 0.49 8.3 9.6 0.47 8.4 6.7 1.0 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.6 CDI79029.1 - 0.61 9.5 12.7 0.58 9.6 8.8 1.1 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.7 CDI79029.1 - 0.81 7.5 15.1 0.82 7.5 10.5 1.0 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.7 CDI79029.1 - 0.88 9.2 12.0 0.91 9.1 8.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.8 CDI79029.1 - 0.99 8.9 12.5 1 8.9 8.6 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Rhabdo_ncap PF00945.13 CDI79029.1 - 1.3 7.4 3.8 1.3 7.5 2.6 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein ANAPC15 PF15243.1 CDI79029.1 - 2.3 8.3 14.6 2.8 8.0 10.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Dicty_REP PF05086.7 CDI79029.1 - 3.9 5.0 12.0 4.1 5.0 8.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Patched PF02460.13 CDI79030.1 - 2.2e-43 148.3 0.0 8e-38 129.9 0.0 2.2 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.3 CDI79030.1 - 4.3e-28 97.6 3.1 1.3e-27 96.1 2.1 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Ribosomal_60s PF00428.14 CDI79030.1 - 0.0078 16.5 7.7 0.0078 16.5 5.4 5.6 5 0 0 5 5 5 3 60s Acidic ribosomal protein DUF4179 PF13786.1 CDI79030.1 - 2.4 8.4 12.7 14 6.0 0.7 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4179) XRN_N PF03159.13 CDI79032.1 - 3.8e-43 147.5 0.0 4.3e-40 137.5 0.0 4.8 3 3 0 4 4 4 2 XRN 5'-3' exonuclease N-terminus CRT10 PF08728.5 CDI79032.1 - 5.3 4.9 5.0 10 3.9 3.5 1.4 1 0 0 1 1 1 0 CRT10 Zip PF02535.17 CDI79032.1 - 6.6 5.6 7.0 16 4.4 0.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2040 PF09745.4 CDI79033.1 - 3e-21 75.5 17.0 2.2e-19 69.5 3.6 4.0 4 0 0 4 4 4 2 Coiled-coil domain-containing protein 55 (DUF2040) RAB3GAP2_N PF14655.1 CDI79033.1 - 0.062 12.2 8.1 0.015 14.3 3.0 1.9 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus tRNA-synt_1c PF00749.16 CDI79035.1 - 4.6e-80 268.6 0.5 4.9e-50 169.9 0.0 4.0 3 1 1 4 4 4 2 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 CDI79035.1 - 5e-54 182.5 0.0 5.1e-49 166.2 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), anti-codon binding domain DDHD PF02862.12 CDI79035.1 - 0.021 14.6 17.4 0.13 12.0 2.2 2.3 2 0 0 2 2 2 0 DDHD domain GOLD_2 PF13897.1 CDI79035.1 - 2.3 8.4 6.4 0.85 9.8 0.2 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking GAGA_bind PF06217.7 CDI79035.1 - 5.5 6.8 15.2 2.6 7.9 1.9 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family CytochromB561_N PF09786.4 CDI79036.1 - 0.0013 17.3 1.7 0.0017 16.8 0.1 1.7 1 1 1 2 2 2 1 Cytochrome B561, N terminal DHH PF01368.15 CDI79036.1 - 0.006 16.2 0.1 0.014 15.0 0.0 1.6 1 1 0 1 1 1 1 DHH family TrbC PF04956.8 CDI79036.1 - 0.61 10.1 7.0 0.96 9.5 4.9 1.4 1 0 0 1 1 1 0 TrbC/VIRB2 family Peptidase_C14 PF00656.17 CDI79036.1 - 4.6 6.8 6.0 5.1 6.7 4.1 1.3 1 1 0 1 1 1 0 Caspase domain TFIIA PF03153.8 CDI79036.1 - 5.9 6.6 7.5 8.2 6.2 5.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TBCA PF02970.11 CDI79037.1 - 5.3e-17 61.6 4.8 5.3e-17 61.6 3.3 2.5 1 1 1 2 2 2 1 Tubulin binding cofactor A HDPD PF02924.9 CDI79037.1 - 0.0031 17.2 0.4 0.0045 16.7 0.3 1.3 1 0 0 1 1 1 1 Bacteriophage lambda head decoration protein D FSH1 PF03959.8 CDI79037.1 - 0.01 15.3 0.8 0.013 14.9 0.6 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Med15 PF09606.5 CDI79037.1 - 0.056 11.6 19.7 0.067 11.3 13.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RNA_pol_Rpb1_1 PF04997.7 CDI79037.1 - 0.099 11.8 0.2 0.099 11.8 0.2 2.1 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 1 Hid1 PF12722.2 CDI79037.1 - 0.3 8.6 5.3 0.35 8.4 3.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1980 PF09323.5 CDI79037.1 - 0.41 10.3 3.7 0.71 9.5 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CDK2AP PF09806.4 CDI79037.1 - 1 9.5 11.4 1.6 8.9 7.9 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Shisa PF13908.1 CDI79037.1 - 2.6 8.1 7.1 4.4 7.4 5.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator XPC-binding PF09280.6 CDI79038.1 - 3.6e-20 71.1 8.1 3.6e-20 71.1 5.6 2.1 2 0 0 2 2 2 1 XPC-binding domain UBA PF00627.26 CDI79038.1 - 4.6e-15 54.9 15.6 2.6e-10 39.8 0.3 3.3 3 0 0 3 3 3 2 UBA/TS-N domain ubiquitin PF00240.18 CDI79038.1 - 0.0013 18.1 0.1 0.0013 18.1 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin family Suf PF05843.9 CDI79038.1 - 0.048 13.3 4.2 0.093 12.4 2.9 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Tnp_P_element PF12017.3 CDI79038.1 - 0.064 12.4 0.8 1.7 7.7 0.1 2.3 2 0 0 2 2 2 0 Transposase protein Rad60-SLD_2 PF13881.1 CDI79038.1 - 0.1 12.5 0.0 0.1 12.5 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like MSP1_C PF07462.6 CDI79038.1 - 0.26 9.6 26.4 0.13 10.6 3.5 2.2 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus DUF2407 PF10302.4 CDI79038.1 - 0.3 11.3 3.4 0.89 9.7 2.4 1.8 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Presenilin PF01080.12 CDI79038.1 - 1.6 7.5 3.4 2.6 6.7 2.4 1.4 1 0 0 1 1 1 0 Presenilin Med15 PF09606.5 CDI79038.1 - 9 4.3 37.3 0.88 7.6 16.2 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1315 PF07023.7 CDI79039.1 - 0.1 12.5 0.2 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1315) Spt20 PF12090.3 CDI79040.1 - 0.0011 18.3 0.7 0.015 14.6 1.8 1.9 2 0 0 2 2 2 1 Spt20 family DUF4557 PF15101.1 CDI79040.1 - 0.012 15.4 6.3 0.012 15.4 4.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) DUF3260 PF11658.3 CDI79040.1 - 0.059 11.5 2.5 0.12 10.4 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Glucan_synthase PF02364.10 CDI79040.1 - 0.21 9.4 2.8 0.28 8.9 2.0 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase component FimP PF09766.4 CDI79040.1 - 1.1 8.2 16.2 0.5 9.3 9.6 1.5 2 0 0 2 2 2 0 Fms-interacting protein Serinc PF03348.10 CDI79040.1 - 4.2 5.9 7.1 0.16 10.6 0.9 1.6 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF1764 PF08576.5 CDI79040.1 - 4.5 8.1 13.3 0.37 11.6 3.8 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Suf PF05843.9 CDI79040.1 - 5.2 6.7 20.9 6.5 6.3 13.4 1.8 1 1 1 2 2 2 0 Suppressor of forked protein (Suf) RAB3GAP2_N PF14655.1 CDI79040.1 - 8.2 5.3 10.8 22 3.8 6.8 2.0 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ham1p_like PF01725.11 CDI79041.1 - 5.4e-18 65.0 0.0 9.6e-09 34.8 0.0 2.0 1 1 1 2 2 2 2 Ham1 family DUF755 PF05501.6 CDI79041.1 - 8.4 6.4 14.7 16 5.5 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Dicty_REP PF05086.7 CDI79042.1 - 0.36 8.5 10.1 0.53 7.9 7.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Macoilin PF09726.4 CDI79042.1 - 1.5 7.0 30.8 0.045 12.0 12.6 2.3 2 0 0 2 2 2 0 Transmembrane protein Ribosomal_L7Ae PF01248.21 CDI79044.1 - 7.9e-25 86.2 0.3 9.7e-25 85.9 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CDI79044.1 - 0.075 12.8 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 TGT PF01702.13 CDI79045.1 - 6.9e-12 45.1 1.0 1.1e-10 41.2 0.0 3.0 2 1 0 2 2 2 1 Queuine tRNA-ribosyltransferase DUF3801 PF12687.2 CDI79045.1 - 7.1 6.1 24.4 1.6 8.2 7.1 3.5 2 2 0 3 3 3 0 Protein of unknown function (DUF3801) WD40 PF00400.27 CDI79046.1 - 6.6e-05 22.6 7.7 0.33 10.8 1.3 5.2 4 0 0 4 4 4 2 WD domain, G-beta repeat AP2 PF00847.15 CDI79047.1 - 2.8e-07 30.5 0.0 2.8e-07 30.5 0.0 5.0 6 1 1 7 7 7 1 AP2 domain APC_CDC26 PF10471.4 CDI79047.1 - 0.0018 18.9 0.4 0.0018 18.9 0.3 9.7 6 2 2 8 8 8 2 Anaphase-promoting complex APC subunit 1 Citrate_synt PF00285.16 CDI79049.1 - 4.4e-89 298.6 2.7 1.1e-88 297.3 0.0 2.6 2 2 0 2 2 2 1 Citrate synthase Phosphoprotein PF00922.12 CDI79049.1 - 0.13 11.4 0.2 0.19 10.9 0.1 1.2 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein DCX PF03607.12 CDI79050.1 - 4.6e-09 35.7 0.0 6.8e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Doublecortin RNase_Zc3h12a PF11977.3 CDI79051.1 - 6.8e-10 38.9 0.0 6.8e-10 38.9 0.0 3.2 3 0 0 3 3 3 1 Zc3h12a-like Ribonuclease NYN domain Nol1_Nop2_Fmu PF01189.12 CDI79052.1 - 2.1e-39 135.6 0.0 3.6e-23 82.3 0.0 3.4 3 1 1 4 4 4 2 NOL1/NOP2/sun family FtsJ PF01728.14 CDI79052.1 - 0.0092 15.9 0.1 0.016 15.1 0.1 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase PAT1 PF09770.4 CDI79052.1 - 0.11 10.7 45.0 0.12 10.6 31.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.1 CDI79052.1 - 0.12 11.2 25.7 0.16 10.8 17.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.2 CDI79052.1 - 7.5 4.0 25.9 11 3.5 18.0 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pkinase PF00069.20 CDI79054.1 - 6.9e-08 31.9 0.0 6.9e-08 31.9 0.0 4.5 3 1 1 4 4 4 2 Protein kinase domain FXa_inhibition PF14670.1 CDI79055.1 - 9.9e-33 111.9 56.3 1e-10 41.5 2.9 6.3 5 1 1 6 6 6 5 Coagulation Factor Xa inhibitory site cEGF PF12662.2 CDI79055.1 - 6.4e-29 99.2 46.3 5.3e-07 29.1 0.1 8.1 8 0 0 8 8 8 6 Complement Clr-like EGF-like EGF_CA PF07645.10 CDI79055.1 - 8.8e-22 76.8 70.4 3.5e-10 39.7 1.2 8.0 9 0 0 9 9 9 5 Calcium-binding EGF domain EGF PF00008.22 CDI79055.1 - 6.8e-18 64.2 51.8 2.6e-05 24.0 1.9 6.6 7 0 0 7 7 7 5 EGF-like domain EGF_3 PF12947.2 CDI79055.1 - 1.3e-11 44.2 50.1 0.002 18.0 0.2 6.8 6 0 0 6 6 6 4 EGF domain EGF_MSP1_1 PF12946.2 CDI79055.1 - 3.2 7.6 41.3 0.053 13.3 1.5 6.8 7 0 0 7 7 7 0 MSP1 EGF domain 1 DHC_N1 PF08385.7 CDI79056.1 - 9.8e-95 318.0 13.8 5.7e-51 173.5 5.3 3.1 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 1 DUF1319 PF07028.6 CDI79056.1 - 0.0018 18.4 4.8 0.31 11.2 0.1 4.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1319) SR-25 PF10500.4 CDI79056.1 - 4.1 6.8 21.0 2.3 7.6 4.8 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AAA_6 PF12774.2 CDI79057.1 - 5.1e-119 395.9 0.1 9.7e-119 395.0 0.1 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N2 PF08393.8 CDI79057.1 - 2.1e-79 266.9 10.6 2.1e-46 158.2 4.6 2.6 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 2 AAA_5 PF07728.9 CDI79057.1 - 4.4e-19 68.5 0.0 3.5e-10 39.7 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CDI79057.1 - 0.00035 21.3 0.4 0.051 14.3 0.0 3.7 4 1 0 4 4 3 1 AAA domain AAA PF00004.24 CDI79057.1 - 0.0021 18.2 0.1 0.041 14.0 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI79057.1 - 0.0063 16.5 0.1 12 5.8 0.0 3.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_30 PF13604.1 CDI79057.1 - 0.0065 16.0 0.0 2.8 7.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 CDI79057.1 - 0.017 15.2 0.1 11 6.2 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.1 CDI79057.1 - 0.029 14.6 0.2 1.9 8.8 0.0 3.1 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.16 CDI79057.1 - 0.069 12.2 0.3 0.34 10.0 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.10 CDI79057.1 - 0.076 11.6 0.1 0.41 9.2 0.0 2.0 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 CDI79057.1 - 0.11 12.7 0.1 31 4.7 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_24 PF13479.1 CDI79057.1 - 2.4 7.6 4.5 1.1e+02 2.2 0.1 3.9 4 0 0 4 4 4 0 AAA domain AAA_7 PF12775.2 CDI79058.1 - 9.7e-06 24.8 0.0 1.9e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 ABC_tran PF00005.22 CDI79058.1 - 0.00058 20.1 0.1 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 CDI79058.1 - 0.00058 19.3 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.8 CDI79058.1 - 0.009 14.9 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.1 CDI79058.1 - 0.017 15.0 0.1 0.039 13.9 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 CDI79058.1 - 0.026 13.7 0.1 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 G-alpha PF00503.15 CDI79058.1 - 0.028 13.1 0.0 0.041 12.5 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit UPF0079 PF02367.12 CDI79058.1 - 0.078 12.6 0.1 0.82 9.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 CDI79058.1 - 0.087 13.6 0.3 0.21 12.4 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 CDI79058.1 - 0.091 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDI79058.1 - 0.091 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 CDI79058.1 - 0.092 13.0 0.1 0.29 11.4 0.2 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 CDI79058.1 - 0.15 11.9 0.2 1 9.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain CPT PF07931.7 CDI79058.1 - 0.16 11.6 0.2 0.35 10.4 0.1 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein BAF1_ABF1 PF04684.8 CDI79063.1 - 0.0068 15.3 25.7 0.0068 15.3 17.8 3.0 3 0 0 3 3 3 1 BAF1 / ABF1 chromatin reorganising factor Med19 PF10278.4 CDI79063.1 - 0.012 15.3 5.0 0.012 15.3 3.5 1.7 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Activator_LAG-3 PF11498.3 CDI79063.1 - 1.2 7.8 46.5 0.13 11.0 15.3 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DDHD PF02862.12 CDI79063.1 - 1.9 8.2 11.8 3.7 7.2 0.1 2.2 2 0 0 2 2 2 0 DDHD domain MMR1 PF08505.5 CDI79063.1 - 4.6 7.2 26.5 1.6 8.6 9.6 2.3 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Pox_Ag35 PF03286.9 CDI79063.1 - 6.3 6.2 10.3 2.1 7.8 2.4 2.4 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Hid1 PF12722.2 CDI79063.1 - 7.5 4.0 17.9 3.1 5.3 1.3 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein MACPF PF01823.14 CDI79063.1 - 8.5 5.9 10.6 0.14 11.8 2.2 1.6 2 0 0 2 2 2 0 MAC/Perforin domain PAT1 PF09770.4 CDI79063.1 - 8.6 4.4 48.5 1.8 6.6 21.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SMC_N PF02463.14 CDI79064.1 - 0.0072 15.5 0.0 0.0072 15.5 0.0 2.3 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDI79064.1 - 0.31 10.9 0.1 0.45 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain LMBR1 PF04791.11 CDI79064.1 - 4.1 5.8 0.0 4.1 5.8 0.0 3.6 2 2 1 3 3 3 0 LMBR1-like membrane protein DUF3458 PF11940.3 CDI79065.1 - 5.8e-53 180.0 3.4 7.8e-53 179.6 2.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) ERAP1_C PF11838.3 CDI79065.1 - 0.0026 17.0 0.5 0.0047 16.2 0.1 1.6 2 0 0 2 2 2 1 ERAP1-like C-terminal domain PPR_3 PF13812.1 CDI79065.1 - 0.11 12.8 1.1 5 7.6 0.0 3.6 4 0 0 4 4 4 0 Pentatricopeptide repeat domain Pkinase PF00069.20 CDI79066.1 - 3.5e-20 72.2 0.0 2.1e-08 33.6 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain EF-hand_1 PF00036.27 CDI79066.1 - 1.7e-08 33.1 0.0 0.0084 15.3 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 CDI79066.1 - 1.1e-06 28.6 0.1 0.18 11.9 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI79066.1 - 5.9e-06 25.7 0.2 0.12 12.2 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 CDI79066.1 - 4e-05 22.7 0.1 0.22 10.9 0.0 2.5 2 0 0 2 2 2 2 EF hand Pkinase_Tyr PF07714.12 CDI79066.1 - 4.1e-05 22.7 0.3 0.18 10.8 0.1 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase EF-hand_8 PF13833.1 CDI79066.1 - 0.00019 20.9 0.1 0.065 12.8 0.0 3.8 4 0 0 4 4 4 1 EF-hand domain pair Amidohydro_4 PF13147.1 CDI79067.1 - 0.00079 19.5 1.4 0.002 18.2 0.0 2.3 3 0 0 3 3 3 1 Amidohydrolase AAA PF00004.24 CDI79068.1 - 7.8e-78 259.0 0.0 3.2e-44 150.3 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 CDI79068.1 - 5.6e-23 80.6 0.6 1.3e-22 79.5 0.4 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 CDI79068.1 - 5.7e-09 36.1 0.0 0.00042 20.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 CDI79068.1 - 2.4e-07 30.9 0.0 0.0073 16.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CDI79068.1 - 2e-06 27.8 0.5 0.0006 19.8 0.0 3.7 3 1 1 4 4 4 1 AAA ATPase domain AAA_25 PF13481.1 CDI79068.1 - 3e-06 26.7 0.2 0.12 11.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.7 CDI79068.1 - 1.5e-05 24.1 0.3 0.00021 20.4 0.0 2.9 3 1 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CDI79068.1 - 9.2e-05 22.3 0.0 0.051 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.5 CDI79068.1 - 0.00014 21.6 0.1 0.0037 17.1 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain CDC48_2 PF02933.12 CDI79068.1 - 0.00015 21.2 0.0 0.00064 19.3 0.0 2.1 1 1 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_17 PF13207.1 CDI79068.1 - 0.00021 22.0 0.0 0.0026 18.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CDI79068.1 - 0.00033 20.3 1.8 0.076 12.7 0.0 3.4 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CDI79068.1 - 0.0016 18.3 0.0 0.0071 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CDI79068.1 - 0.0044 16.6 0.0 0.44 10.1 0.0 2.8 2 1 0 3 3 3 1 NACHT domain KaiC PF06745.8 CDI79068.1 - 0.0059 15.7 0.0 2.2 7.3 0.0 2.3 2 0 0 2 2 2 1 KaiC RNA_helicase PF00910.17 CDI79068.1 - 0.0066 16.5 0.0 0.017 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Viral_helicase1 PF01443.13 CDI79068.1 - 0.0079 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 CDI79068.1 - 0.013 15.2 0.0 1.7 8.2 0.0 2.5 2 1 1 3 3 3 0 Archaeal ATPase Mg_chelatase PF01078.16 CDI79068.1 - 0.013 14.6 0.1 0.034 13.2 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 CDI79068.1 - 0.018 14.1 0.0 0.039 13.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TIP49 PF06068.8 CDI79068.1 - 0.022 13.4 0.0 0.041 12.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus IstB_IS21 PF01695.12 CDI79068.1 - 0.024 14.0 0.0 0.051 12.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.1 CDI79068.1 - 0.027 14.2 0.0 0.18 11.6 0.0 2.4 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 CDI79068.1 - 0.037 14.3 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.1 CDI79068.1 - 0.058 13.3 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.22 CDI79068.1 - 0.071 13.4 0.0 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.10 CDI79068.1 - 0.072 12.7 0.0 2.8 7.6 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.1 CDI79068.1 - 0.14 11.6 0.0 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 CDI79068.1 - 0.18 10.6 0.0 0.36 9.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.12 CDI79068.1 - 0.3 9.9 0.0 0.48 9.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 UCH PF00443.24 CDI79069.1 - 1.2e-34 119.6 0.0 1.2e-34 119.6 0.0 4.8 3 2 1 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase ABC_tran PF00005.22 CDI79071.1 - 1.4e-45 154.9 1.0 3.9e-22 79.0 0.0 3.4 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 CDI79071.1 - 1.5e-21 77.6 7.9 1.7e-09 38.0 1.8 5.1 4 1 0 4 4 4 3 AAA domain ABC_tran_2 PF12848.2 CDI79071.1 - 3.6e-17 61.9 0.6 3.6e-17 61.9 0.4 4.0 4 0 0 4 4 4 1 ABC transporter SMC_N PF02463.14 CDI79071.1 - 4.9e-10 39.0 5.0 0.00032 19.9 0.0 4.9 3 2 1 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CDI79071.1 - 1.1e-07 32.7 0.8 0.0024 18.6 0.1 3.4 3 1 0 3 3 2 2 AAA domain AAA_15 PF13175.1 CDI79071.1 - 1.1e-07 31.2 8.5 0.16 10.9 0.0 4.7 4 1 0 4 4 4 2 AAA ATPase domain AAA_29 PF13555.1 CDI79071.1 - 2.5e-07 30.1 0.5 0.016 14.7 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 CDI79071.1 - 9.5e-07 28.1 0.2 0.039 13.1 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 CDI79071.1 - 6.3e-06 26.6 0.0 0.18 12.3 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein MMR_HSR1 PF01926.18 CDI79071.1 - 6.9e-06 26.0 0.0 0.14 12.1 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.1 CDI79071.1 - 8.2e-06 25.7 0.0 0.025 14.4 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.1 CDI79071.1 - 0.00033 20.9 6.3 0.047 13.9 0.0 5.1 6 0 0 6 6 6 1 AAA domain AAA_10 PF12846.2 CDI79071.1 - 0.00039 19.9 0.1 0.05 13.0 0.0 2.8 3 0 0 3 3 3 1 AAA-like domain NACHT PF05729.7 CDI79071.1 - 0.00049 19.7 0.3 0.8 9.3 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_14 PF13173.1 CDI79071.1 - 0.00062 19.6 0.0 1.1 9.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.15 CDI79071.1 - 0.00081 18.1 0.2 0.00081 18.1 0.1 2.4 2 1 0 2 2 1 1 G-protein alpha subunit Dynamin_N PF00350.18 CDI79071.1 - 0.00084 19.1 9.7 0.052 13.3 0.0 3.8 4 0 0 4 4 3 2 Dynamin family AAA_22 PF13401.1 CDI79071.1 - 0.00093 19.3 5.7 0.48 10.5 0.2 4.0 3 2 0 3 3 3 2 AAA domain FtsK_SpoIIIE PF01580.13 CDI79071.1 - 0.0013 18.3 1.2 1.1 8.7 0.0 3.1 3 0 0 3 3 3 2 FtsK/SpoIIIE family AAA_28 PF13521.1 CDI79071.1 - 0.0016 18.4 6.4 0.076 12.9 0.0 3.5 4 0 0 4 4 3 2 AAA domain MobB PF03205.9 CDI79071.1 - 0.0059 16.3 0.0 0.93 9.1 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.1 CDI79071.1 - 0.0075 16.1 0.1 2 8.3 0.0 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 CDI79071.1 - 0.0092 15.3 0.0 2.3 7.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CDI79071.1 - 0.012 15.8 0.0 5.8 7.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Arf PF00025.16 CDI79071.1 - 0.012 14.8 0.1 0.59 9.3 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family ArgK PF03308.11 CDI79071.1 - 0.02 13.6 0.0 4.5 5.9 0.0 2.6 2 0 0 2 2 2 0 ArgK protein NB-ARC PF00931.17 CDI79071.1 - 0.03 13.1 0.0 5.1 5.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.1 CDI79071.1 - 0.044 14.0 0.2 0.044 14.0 0.1 4.8 3 2 2 5 5 4 0 AAA domain Seryl_tRNA_N PF02403.17 CDI79071.1 - 0.063 13.3 0.0 0.063 13.3 0.0 4.0 4 0 0 4 4 2 0 Seryl-tRNA synthetase N-terminal domain ATP_bind_1 PF03029.12 CDI79071.1 - 0.069 12.6 0.7 5.1 6.5 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein ATP-synt_ab PF00006.20 CDI79071.1 - 0.076 12.5 0.0 0.3 10.5 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.1 CDI79071.1 - 0.12 12.3 0.1 0.12 12.3 0.1 3.8 4 1 0 4 4 4 0 AAA ATPase domain DUF87 PF01935.12 CDI79071.1 - 2 8.1 7.7 2.5 7.8 0.1 3.5 2 1 1 3 3 3 0 Domain of unknown function DUF87 PseudoU_synth_2 PF00849.17 CDI79072.1 - 0.00042 20.2 0.0 0.00068 19.4 0.0 1.7 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.20 CDI79072.1 - 0.0027 17.1 0.0 0.0067 15.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain DUF755 PF05501.6 CDI79072.1 - 0.0066 16.5 9.1 0.0066 16.5 6.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF755) DUF3827 PF12877.2 CDI79072.1 - 1.9 6.5 8.5 2.8 5.9 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) SR-25 PF10500.4 CDI79072.1 - 5.2 6.4 21.1 8.8 5.7 14.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 CDI79072.1 - 7.2 4.7 11.0 11 4.1 7.6 1.2 1 0 0 1 1 1 0 Transmembrane protein Alba PF01918.16 CDI79074.1 - 7.3e-14 51.1 0.0 1.1e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Alba FoP_duplication PF13865.1 CDI79074.1 - 0.00013 22.3 1.9 0.00032 21.0 1.3 1.6 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Rpp20 PF12328.3 CDI79074.1 - 0.0079 15.8 1.0 0.01 15.4 0.0 1.8 2 0 0 2 2 2 1 Rpp20 subunit of nuclear RNase MRP and P MCM PF00493.18 CDI79075.1 - 1.4e-91 306.7 0.7 9.5e-91 304.0 0.5 1.9 1 1 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 CDI79075.1 - 5.8e-10 38.6 0.5 2.5e-09 36.5 0.3 2.1 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDI79075.1 - 4.5e-06 26.4 0.0 1.6e-05 24.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDI79075.1 - 0.0035 17.3 0.6 0.0035 17.3 0.4 3.1 3 2 0 3 3 3 1 AAA ATPase domain AAA PF00004.24 CDI79075.1 - 0.0049 17.0 0.0 0.018 15.2 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI79075.1 - 0.0053 16.8 0.5 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 CDI79075.1 - 0.012 15.0 0.6 0.037 13.5 0.4 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Miro PF08477.8 CDI79075.1 - 0.02 15.3 0.0 0.048 14.1 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 CDI79075.1 - 0.026 14.0 0.0 0.063 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_3 PF07726.6 CDI79075.1 - 0.041 13.4 0.0 0.31 10.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 CDI79075.1 - 0.044 12.7 0.1 0.11 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_2 PF07724.9 CDI79075.1 - 0.18 11.6 0.0 0.59 10.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) MMR_HSR1 PF01926.18 CDI79075.1 - 0.2 11.6 0.1 0.8 9.6 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF755 PF05501.6 CDI79076.1 - 0.0075 16.3 16.0 0.0075 16.3 11.1 12.0 12 1 1 13 13 13 2 Domain of unknown function (DUF755) UPF0054 PF02130.12 CDI79077.1 - 1.7e-12 46.8 0.0 1.4e-07 30.9 0.0 3.4 3 0 0 3 3 3 2 Uncharacterized protein family UPF0054 ACPS PF01648.15 CDI79077.1 - 2.3e-12 46.7 0.2 1.3e-09 37.8 0.0 3.2 3 1 0 3 3 3 2 4'-phosphopantetheinyl transferase superfamily Med3 PF11593.3 CDI79078.1 - 0.0039 16.4 23.2 0.0039 16.4 16.1 3.3 2 1 0 3 3 3 1 Mediator complex subunit 3 fungal UCR_Fe-S_N PF10399.4 CDI79079.1 - 0.0071 15.4 1.6 0.0071 15.4 1.1 2.9 2 1 0 2 2 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF4367 PF14285.1 CDI79079.1 - 0.072 12.4 3.7 0.76 9.0 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) CD99L2 PF12301.3 CDI79079.1 - 0.078 12.6 0.4 0.13 11.9 0.3 1.4 1 0 0 1 1 1 0 CD99 antigen like protein 2 DUF1645 PF07816.6 CDI79079.1 - 0.079 13.4 7.5 0.11 12.8 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) UPF0093 PF03653.8 CDI79079.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0093) DUF92 PF01940.11 CDI79079.1 - 0.15 11.1 0.2 0.15 11.1 0.1 2.0 2 0 0 2 2 2 0 Integral membrane protein DUF92 Herpes_US9 PF06072.6 CDI79079.1 - 0.16 11.7 0.3 0.16 11.7 0.2 2.0 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 UCR_TM PF02921.9 CDI79079.1 - 0.36 11.0 0.1 0.36 11.0 0.1 3.2 3 1 0 3 3 3 0 Ubiquinol cytochrome reductase transmembrane region DUF677 PF05055.7 CDI79079.1 - 1.1 7.8 5.4 0.85 8.2 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF677) Claudin_2 PF13903.1 CDI79079.1 - 1.9 8.1 7.1 19 4.8 4.9 2.2 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Shadoo PF14999.1 CDI79079.1 - 2.2 8.1 16.3 2.3 8.0 0.2 2.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Ribosomal_60s PF00428.14 CDI79079.1 - 3.3 8.1 24.7 4.8 7.6 8.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Gly-zipper_OmpA PF13436.1 CDI79079.1 - 3.4 7.3 18.1 0.35 10.5 1.7 2.3 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain RskA PF10099.4 CDI79079.1 - 4.9 6.8 27.6 0.099 12.3 5.3 2.1 1 1 0 2 2 2 0 Anti-sigma-K factor rskA SR-25 PF10500.4 CDI79079.1 - 5.1 6.4 19.5 11 5.4 13.0 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein rve PF00665.21 CDI79081.1 - 3.4e-12 46.5 0.0 6.4e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 CDI79081.1 - 0.014 14.9 0.1 0.024 14.1 0.1 1.4 1 0 0 1 1 1 0 Integrase core domain Metallophos PF00149.23 CDI79082.1 - 2.3e-27 95.6 0.7 3.9e-27 94.9 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_7 PF13499.1 CDI79082.1 - 8.4e-22 77.0 3.4 6.6e-07 29.3 0.1 4.9 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 CDI79082.1 - 1.3e-19 67.8 8.3 0.0003 19.8 0.1 8.1 8 0 0 8 8 8 4 EF hand EF-hand_8 PF13833.1 CDI79082.1 - 2.2e-14 52.8 12.1 2.5e-09 36.6 0.2 5.2 6 0 0 6 6 6 3 EF-hand domain pair EF-hand_6 PF13405.1 CDI79082.1 - 1.8e-13 49.1 7.5 0.093 12.6 0.0 7.9 6 1 1 7 7 7 3 EF-hand domain CAP_GLY PF01302.20 CDI79082.1 - 5e-12 45.3 0.9 9.1e-12 44.5 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_5 PF13202.1 CDI79082.1 - 3e-07 29.4 6.7 0.00071 18.8 0.0 5.0 5 0 0 5 5 5 2 EF hand EF-hand_4 PF12763.2 CDI79082.1 - 0.28 10.9 1.4 14 5.4 0.0 3.6 2 2 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand DUF1880 PF08976.6 CDI79082.1 - 4.2 7.5 9.2 3.1e+02 1.4 6.2 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1880) ECH_C PF13766.1 CDI79084.1 - 1.2e-08 35.1 0.3 4.4e-08 33.2 0.1 2.0 2 0 0 2 2 2 1 2-enoyl-CoA Hydratase C-terminal region zf-met PF12874.2 CDI79085.1 - 0.00026 21.0 0.1 0.00047 20.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Shadoo PF14999.1 CDI79085.1 - 0.071 12.9 5.3 0.75 9.6 1.2 2.7 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Med15 PF09606.5 CDI79087.1 - 0.0041 15.3 19.9 0.13 10.4 0.6 2.1 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI79087.1 - 0.0066 16.2 5.9 0.036 13.7 1.6 2.2 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) Cyclin_C PF02984.14 CDI79087.1 - 0.016 15.1 0.1 0.016 15.1 0.1 3.7 3 1 0 3 3 3 0 Cyclin, C-terminal domain RAB3GAP2_N PF14655.1 CDI79087.1 - 0.27 10.1 5.2 3.1 6.7 1.4 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Spt20 PF12090.3 CDI79087.1 - 4.5 6.5 10.5 21 4.4 0.1 2.2 2 0 0 2 2 2 0 Spt20 family OmpH PF03938.9 CDI79088.1 - 6.4e-05 22.9 0.0 6.4e-05 22.9 0.0 16.2 9 5 0 10 10 10 1 Outer membrane protein (OmpH-like) DUF966 PF06136.8 CDI79090.1 - 0.28 10.5 17.6 0.34 10.2 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) ORC3_N PF07034.6 CDI79090.1 - 1.5 7.6 9.1 1.9 7.3 6.3 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus MIP-T3 PF10243.4 CDI79090.1 - 2 6.7 6.3 2.1 6.7 4.4 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF572 PF04502.8 CDI79090.1 - 7.7 5.6 13.2 12 5.0 9.2 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF572) FATC PF02260.15 CDI79091.1 - 0.00014 21.1 0.0 0.00025 20.4 0.0 1.4 1 0 0 1 1 1 1 FATC domain DUF4647 PF15504.1 CDI79091.1 - 0.032 13.1 5.5 0.033 13.0 3.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) RIC3 PF15361.1 CDI79091.1 - 0.12 12.5 5.0 0.69 10.1 0.5 2.1 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 APC_CDC26 PF10471.4 CDI79091.1 - 0.35 11.6 19.2 1.5 9.5 4.4 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 FKBP_N PF01346.13 CDI79091.1 - 0.48 10.4 9.6 1.8 8.6 1.1 2.3 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase YihI PF04220.7 CDI79091.1 - 0.88 8.8 13.1 0.029 13.6 2.0 2.1 1 1 2 3 3 3 0 Der GTPase activator (YihI) CD99L2 PF12301.3 CDI79091.1 - 1.3 8.7 5.3 0.55 9.9 1.7 1.7 2 0 0 2 2 2 0 CD99 antigen like protein 2 PHD_3 PF13922.1 CDI79091.1 - 1.3 9.3 11.2 5.5 7.2 1.6 2.4 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx Pex16 PF08610.5 CDI79091.1 - 9.6 5.0 8.4 0.22 10.4 0.5 1.8 1 1 1 2 2 2 0 Peroxisomal membrane protein (Pex16) zf-Apc11 PF12861.2 CDI79092.1 - 3.1e-22 78.2 5.7 4.2e-22 77.8 4.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 CDI79092.1 - 4.2e-21 74.8 5.7 5.7e-21 74.4 4.0 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CDI79092.1 - 2.5e-06 27.2 14.2 1e-05 25.2 9.8 2.1 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CDI79092.1 - 7.4e-06 25.5 9.3 5e-05 22.9 6.6 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDI79092.1 - 6.8e-05 22.4 6.1 0.00013 21.5 4.2 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI79092.1 - 0.00012 22.0 9.4 0.0022 17.9 6.5 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDI79092.1 - 0.0012 18.5 9.4 0.0094 15.6 6.5 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) NIPSNAP PF07978.8 CDI79092.1 - 0.018 14.9 0.4 0.025 14.5 0.2 1.2 1 0 0 1 1 1 0 NIPSNAP RskA PF10099.4 CDI79092.1 - 0.019 14.6 3.3 0.025 14.3 2.3 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Pellino PF04710.9 CDI79092.1 - 0.051 12.2 0.2 0.059 12.0 0.1 1.1 1 0 0 1 1 1 0 Pellino zf-C3HC4_4 PF15227.1 CDI79092.1 - 0.17 11.7 9.9 1.7 8.6 4.7 2.7 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 CDI79092.1 - 0.55 9.7 5.2 0.88 9.1 3.6 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.2 CDI79092.1 - 0.77 9.8 7.0 0.88 9.6 2.6 2.2 2 0 0 2 2 2 0 RING-variant domain Opy2 PF09463.5 CDI79092.1 - 1.4 9.0 11.2 1.5 8.9 4.4 2.2 2 0 0 2 2 2 0 Opy2 protein FYDLN_acid PF09538.5 CDI79092.1 - 2.3 8.8 5.0 0.32 11.5 0.8 1.5 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) C1_1 PF00130.17 CDI79092.1 - 2.7 7.7 6.9 1.2 8.9 1.9 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.24 CDI79092.1 - 3.4 7.4 9.8 35 4.1 6.8 2.3 1 1 0 1 1 1 0 PHD-finger zf-HIT PF04438.11 CDI79092.1 - 4.1 7.1 10.6 0.31 10.7 3.3 2.0 2 0 0 2 2 2 0 HIT zinc finger FANCL_C PF11793.3 CDI79092.1 - 6.8 6.7 14.0 45 4.0 9.7 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Cys_Met_Meta_PP PF01053.15 CDI79095.1 - 1.2e-117 392.5 0.0 2.9e-67 226.6 0.0 2.0 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 CDI79095.1 - 1.1e-07 31.2 0.0 2e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CDI79095.1 - 0.029 13.3 0.0 0.049 12.5 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Rad60-SLD_2 PF13881.1 CDI79097.1 - 0.18 11.6 1.4 0.55 10.1 0.4 2.2 2 1 1 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like UPF0081 PF03652.10 CDI79098.1 - 8.2e-06 25.9 0.1 8.2e-06 25.9 0.0 4.0 4 1 0 4 4 4 2 Uncharacterised protein family (UPF0081) Band_3_cyto PF07565.8 CDI79098.1 - 0.0048 16.4 3.4 0.0048 16.4 2.4 2.4 2 1 0 2 2 2 1 Band 3 cytoplasmic domain PBP1_TM PF14812.1 CDI79098.1 - 1.4 9.2 13.3 0.077 13.3 3.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SID-1_RNA_chan PF13965.1 CDI79098.1 - 2.4 6.2 8.4 2.6 6.1 1.3 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 GOLD_2 PF13897.1 CDI79098.1 - 4.1 7.6 11.6 1.1e+02 2.9 0.0 3.1 3 0 0 3 3 3 0 Golgi-dynamics membrane-trafficking Nucleoside_tran PF01733.13 CDI79098.1 - 4.3 6.4 6.0 0.31 10.1 0.3 1.7 2 0 0 2 2 2 0 Nucleoside transporter Anoctamin PF04547.7 CDI79098.1 - 6.9 5.1 13.6 0.73 8.4 5.0 2.0 2 0 0 2 2 2 0 Calcium-activated chloride channel Pex2_Pex12 PF04757.9 CDI79099.1 - 1.7e-11 44.0 22.0 7.7e-11 41.8 15.3 2.0 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region LMBR1 PF04791.11 CDI79099.1 - 1.1 7.7 4.3 2 6.9 3.0 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Mg_trans_NIPA PF05653.9 CDI79100.1 - 6.4e-11 41.7 7.9 4.5e-07 29.1 0.4 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.15 CDI79100.1 - 0.014 15.4 0.3 0.014 15.4 0.2 3.8 4 1 0 4 4 4 0 EamA-like transporter family Sod_Fe_C PF02777.13 CDI79102.1 - 3.8e-18 65.2 0.1 9.9e-18 63.9 0.0 1.7 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 CDI79102.1 - 0.00022 21.3 0.0 0.00058 20.0 0.0 1.8 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF1631 PF07793.6 CDI79102.1 - 1.9 6.5 10.1 2.4 6.2 7.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Sec62 PF03839.11 CDI79103.1 - 0.00026 20.4 0.0 0.00026 20.4 0.0 3.0 3 0 0 3 3 3 1 Translocation protein Sec62 SprA-related PF12118.3 CDI79104.1 - 0.67 9.2 21.5 0.53 9.5 8.7 2.3 2 0 0 2 2 2 0 SprA-related family Ank_2 PF12796.2 CDI79105.1 - 4.9e-11 42.8 6.2 2.6e-10 40.5 0.5 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CDI79105.1 - 3.6e-08 33.4 9.7 0.0028 17.8 0.1 4.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDI79105.1 - 9.8e-08 32.3 2.5 4.5e-06 27.0 0.1 4.5 3 2 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.25 CDI79105.1 - 8.1e-05 22.2 6.7 0.0011 18.6 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 CDI79105.1 - 0.047 13.9 8.3 0.051 13.8 0.1 4.6 6 0 0 6 6 6 0 Ankyrin repeat Sporozoite_P67 PF05642.6 CDI79105.1 - 1 7.1 6.1 2.3 5.9 4.2 1.6 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_L10 PF00466.15 CDI79107.1 - 1e-11 44.6 0.4 1.4e-11 44.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Pkinase PF00069.20 CDI79108.1 - 1.9e-09 37.1 19.7 7.4e-08 31.8 0.0 6.1 6 1 0 6 6 6 2 Protein kinase domain Zip PF02535.17 CDI79108.1 - 0.00023 20.2 0.3 0.00023 20.2 0.2 7.8 8 0 0 8 8 8 3 ZIP Zinc transporter Suf PF05843.9 CDI79108.1 - 0.0093 15.7 0.5 0.0093 15.7 0.3 13.4 10 5 3 13 13 13 4 Suppressor of forked protein (Suf) OmpH PF03938.9 CDI79109.1 - 6.6e-05 22.8 7.3 6.6e-05 22.8 5.1 6.7 5 4 1 6 6 6 2 Outer membrane protein (OmpH-like) Pyr_redox_dim PF02852.17 CDI79110.1 - 6.6e-24 84.0 0.0 2.3e-23 82.3 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 CDI79110.1 - 5.2e-22 78.7 0.5 1e-16 61.4 0.0 3.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI79110.1 - 2.1e-13 50.4 2.9 3.4e-13 49.8 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDI79110.1 - 2.7e-07 30.8 0.6 4.3e-06 26.9 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CDI79110.1 - 0.00022 20.2 0.0 0.0014 17.6 0.0 1.9 1 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Proteasome PF00227.21 CDI79111.1 - 4e-23 81.6 0.1 4.8e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Ribonuc_red_sm PF00268.16 CDI79112.1 - 1.4e-109 365.4 0.4 1.7e-109 365.1 0.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain cobW PF02492.14 CDI79113.1 - 3.8e-34 117.6 0.1 7.4e-34 116.7 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 CDI79113.1 - 0.00045 20.1 1.1 0.0016 18.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 CDI79113.1 - 0.0029 17.9 5.7 0.05 13.9 0.1 3.0 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 CDI79113.1 - 0.0036 17.0 0.2 0.0036 17.0 0.1 3.3 4 0 0 4 4 3 1 Part of AAA domain MobB PF03205.9 CDI79113.1 - 0.0075 15.9 0.0 0.03 14.0 0.0 2.0 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 CDI79113.1 - 0.0084 15.5 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 AAA-like domain UPF0079 PF02367.12 CDI79113.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 CDI79113.1 - 0.022 14.9 1.8 0.2 11.8 0.2 2.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CDI79113.1 - 0.026 14.8 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CDI79113.1 - 0.027 14.4 0.0 0.41 10.6 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase CbiA PF01656.18 CDI79113.1 - 0.029 13.7 0.1 0.072 12.4 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.22 CDI79113.1 - 0.032 14.5 0.7 0.12 12.6 0.2 2.1 2 1 0 2 2 2 0 ABC transporter Arch_ATPase PF01637.13 CDI79113.1 - 0.051 13.2 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_14 PF13173.1 CDI79113.1 - 0.072 12.9 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain CLU PF13236.1 CDI79113.1 - 0.2 11.0 0.8 0.42 10.0 0.6 1.4 1 0 0 1 1 1 0 Clustered mitochondria NACHT PF05729.7 CDI79113.1 - 0.2 11.2 4.9 0.43 10.2 1.8 2.6 2 1 0 2 2 1 0 NACHT domain Ribosomal_60s PF00428.14 CDI79113.1 - 0.29 11.5 33.6 0.15 12.4 5.7 3.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF2489 PF10675.4 CDI79113.1 - 3.5 7.3 12.0 4.6 6.9 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) AAA_16 PF13191.1 CDI79113.1 - 5.1 7.0 13.3 0.084 12.8 2.8 2.7 2 2 0 2 2 2 0 AAA ATPase domain TPR_11 PF13414.1 CDI79114.1 - 1.1e-24 85.8 6.9 5e-13 48.4 0.7 4.3 2 1 0 3 3 3 3 TPR repeat TPR_1 PF00515.23 CDI79114.1 - 1.2e-16 59.4 5.8 7.9e-06 25.2 0.1 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.12 CDI79114.1 - 3e-15 54.8 8.7 0.00037 20.1 0.1 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 CDI79114.1 - 5.1e-10 38.3 0.7 0.012 15.3 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDI79114.1 - 7.1e-09 35.1 3.4 0.00043 20.2 0.2 5.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDI79114.1 - 4.8e-05 22.8 0.9 0.82 9.6 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat CDC48_N PF02359.13 CDI79116.1 - 0.037 13.9 0.0 0.93 9.4 0.0 2.2 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain Molydop_binding PF01568.16 CDI79116.1 - 0.06 13.1 0.0 0.45 10.3 0.0 2.0 1 1 1 2 2 2 0 Molydopterin dinucleotide binding domain Lectin_N PF03954.9 CDI79116.1 - 0.26 10.7 0.6 0.49 9.7 0.4 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Ribosomal_60s PF00428.14 CDI79118.1 - 5.4e-24 84.4 12.7 6.4e-24 84.1 8.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein NIL PF09383.5 CDI79118.1 - 0.046 13.3 0.1 0.063 12.8 0.1 1.2 1 0 0 1 1 1 0 NIL domain VPS9 PF02204.13 CDI79121.1 - 5.6e-29 100.2 0.0 1.3e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ycf1 PF05758.7 CDI79122.1 - 0.00029 18.7 6.3 0.00029 18.7 4.3 3.0 3 1 0 3 3 3 1 Ycf1 SR-25 PF10500.4 CDI79122.1 - 0.0014 18.1 1.5 0.0014 18.1 1.0 8.2 8 2 1 9 9 9 3 Nuclear RNA-splicing-associated protein Pkinase PF00069.20 CDI79122.1 - 0.035 13.2 0.0 0.035 13.2 0.0 3.2 1 1 0 2 2 2 0 Protein kinase domain Otopetrin PF03189.8 CDI79122.1 - 0.26 10.2 7.5 0.068 12.1 0.2 2.4 2 0 0 2 2 2 0 Otopetrin 2TM PF13239.1 CDI79122.1 - 0.42 10.7 0.0 39 4.4 0.0 2.7 2 0 0 2 2 2 0 2TM domain Peptidase_M56 PF05569.6 CDI79122.1 - 6.6 5.6 4.5 4.2 6.2 0.0 2.6 3 0 0 3 3 3 0 BlaR1 peptidase M56 SpoIIIAH PF12685.2 CDI79123.1 - 2.9 7.3 11.6 33 3.8 8.0 2.0 1 1 0 1 1 1 0 SpoIIIAH-like protein Suf PF05843.9 CDI79124.1 - 0.29 10.8 12.8 1 9.0 0.9 2.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Ycf1 PF05758.7 CDI79124.1 - 0.49 8.0 2.7 0.58 7.8 0.2 1.9 2 0 0 2 2 2 0 Ycf1 Spt20 PF12090.3 CDI79124.1 - 1.2 8.3 11.5 0.83 8.9 0.4 2.5 2 0 0 2 2 2 0 Spt20 family Zip PF02535.17 CDI79124.1 - 4.5 6.1 9.7 25 3.7 5.9 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter YEATS PF03366.11 CDI79125.1 - 4.7e-09 35.8 0.6 1.2e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 YEATS family PAT1 PF09770.4 CDI79125.1 - 0.029 12.6 51.7 0.032 12.5 35.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI79125.1 - 0.073 11.2 64.4 0.087 11.0 44.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RNA_pol_A_bac PF01000.21 CDI79126.1 - 0.00011 22.3 0.0 0.00039 20.5 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 CDI79126.1 - 0.0014 17.7 0.0 0.0017 17.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Ycf1 PF05758.7 CDI79126.1 - 0.002 15.9 4.2 0.0038 15.0 2.9 1.4 1 0 0 1 1 1 1 Ycf1 PRTP PF01366.13 CDI79126.1 - 0.01 13.9 4.0 0.019 12.9 2.8 1.4 1 0 0 1 1 1 1 Herpesvirus processing and transport protein OmpH PF03938.9 CDI79126.1 - 0.12 12.3 0.0 0.12 12.3 0.0 3.8 2 2 0 2 2 1 0 Outer membrane protein (OmpH-like) CDC45 PF02724.9 CDI79126.1 - 0.12 10.3 8.9 0.27 9.2 6.2 1.5 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.1 CDI79126.1 - 0.15 11.7 7.8 0.48 10.1 5.4 1.8 1 0 0 1 1 1 0 Protein Family FAM60A Zip PF02535.17 CDI79126.1 - 0.36 9.8 0.7 0.89 8.5 0.5 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter Plasmodium_Vir PF05795.6 CDI79126.1 - 0.49 9.5 2.0 0.46 9.6 0.3 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Ndc1_Nup PF09531.5 CDI79126.1 - 0.51 8.6 11.1 1.2 7.5 7.7 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Glyco_transf_15 PF01793.11 CDI79126.1 - 0.79 8.6 12.2 1.7 7.5 8.5 1.5 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Bul1_N PF04425.7 CDI79126.1 - 0.95 7.9 14.9 1.8 7.0 10.3 1.3 1 0 0 1 1 1 0 Bul1 N terminus LMBR1 PF04791.11 CDI79126.1 - 3.2 6.2 1.8 5.8 5.3 1.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_S64 PF08192.6 CDI79126.1 - 5.6 5.1 10.0 11 4.2 6.9 1.4 1 0 0 1 1 1 0 Peptidase family S64 Cellulose_synt PF03552.9 CDI79126.1 - 5.7 5.0 4.1 8.7 4.4 2.9 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF4220 PF13968.1 CDI79126.1 - 7.9 5.4 3.6 15 4.5 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) GAGA_bind PF06217.7 CDI79126.1 - 9 6.1 20.0 0.79 9.6 10.0 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family SprA-related PF12118.3 CDI79127.1 - 0.003 16.9 34.0 0.0036 16.6 23.5 1.1 1 0 0 1 1 1 1 SprA-related family CAF-1_p150 PF11600.3 CDI79127.1 - 0.0063 15.9 24.5 0.0091 15.4 17.0 1.2 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Suf PF05843.9 CDI79127.1 - 0.025 14.3 18.1 0.031 14.0 12.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Smg4_UPF3 PF03467.10 CDI79127.1 - 0.037 14.0 0.1 0.037 14.0 0.1 2.3 1 1 1 2 2 1 0 Smg-4/UPF3 family RR_TM4-6 PF06459.7 CDI79127.1 - 0.074 12.9 17.6 0.099 12.5 12.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDRGK PF09756.4 CDI79127.1 - 0.094 12.1 12.7 0.12 11.7 8.8 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4175 PF13779.1 CDI79127.1 - 0.099 10.3 28.6 0.095 10.3 19.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2201_N PF13203.1 CDI79127.1 - 0.18 10.9 18.1 0.24 10.5 12.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain PA26 PF04636.8 CDI79127.1 - 0.25 10.0 10.7 0.3 9.7 7.4 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hex_IIIa PF02455.11 CDI79127.1 - 0.29 9.7 17.7 0.33 9.5 12.3 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF605 PF04652.11 CDI79127.1 - 0.29 10.5 31.0 0.33 10.2 21.5 1.1 1 0 0 1 1 1 0 Vta1 like Corona_nucleoca PF00937.13 CDI79127.1 - 0.32 9.8 28.8 0.43 9.4 20.0 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Med15 PF09606.5 CDI79127.1 - 0.6 8.2 42.7 0.76 7.9 29.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3337 PF11816.3 CDI79127.1 - 0.67 9.2 16.8 0.83 8.9 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) SOBP PF15279.1 CDI79127.1 - 0.67 10.2 23.5 0.81 10.0 16.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SAGA-Tad1 PF12767.2 CDI79127.1 - 0.75 9.4 23.6 0.87 9.1 16.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF853 PF05872.7 CDI79127.1 - 0.78 8.0 10.4 0.84 7.9 7.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) TFIIA PF03153.8 CDI79127.1 - 0.92 9.3 32.5 1.1 9.0 22.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.17 CDI79127.1 - 0.95 8.4 6.0 1.3 7.9 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_S49_N PF08496.5 CDI79127.1 - 0.95 9.2 8.4 1.3 8.7 5.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PAT1 PF09770.4 CDI79127.1 - 2.8 6.0 36.7 3.4 5.8 25.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S64 PF08192.6 CDI79127.1 - 3.1 6.0 20.6 3.7 5.7 14.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.4 CDI79127.1 - 3.2 6.4 19.0 4.8 5.9 13.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4407 PF14362.1 CDI79127.1 - 4.5 6.1 15.1 5.4 5.8 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDK5_activator PF03261.10 CDI79127.1 - 5 6.3 21.9 6.3 6.0 15.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Mnd1 PF03962.10 CDI79127.1 - 5 6.7 18.6 6.7 6.3 12.9 1.2 1 0 0 1 1 1 0 Mnd1 family Hid1 PF12722.2 CDI79127.1 - 5.7 4.4 23.2 7.1 4.1 16.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FLO_LFY PF01698.11 CDI79127.1 - 8.1 5.1 15.4 9.5 4.9 10.6 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF572 PF04502.8 CDI79127.1 - 9 5.4 24.7 11 5.0 17.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) zf-CCHC_3 PF13917.1 CDI79129.1 - 5.7e-05 22.7 0.3 5.7e-05 22.7 0.2 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 CDI79129.1 - 0.00019 21.2 1.3 0.0003 20.5 0.9 1.4 1 0 0 1 1 1 1 Zinc knuckle Apt1 PF10351.4 CDI79129.1 - 0.0084 15.0 9.8 0.0075 15.1 6.8 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain DUF572 PF04502.8 CDI79129.1 - 0.011 15.0 16.5 0.012 14.9 11.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PSP PF04046.11 CDI79129.1 - 0.047 13.0 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 PSP UPF0560 PF10577.4 CDI79129.1 - 0.05 11.8 13.9 0.056 11.7 9.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4603 PF15376.1 CDI79129.1 - 0.11 9.7 12.0 0.1 9.8 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) SR-25 PF10500.4 CDI79129.1 - 0.16 11.4 45.7 0.17 11.2 31.0 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_DNAp_acc PF04929.7 CDI79129.1 - 0.94 8.3 13.9 1.1 8.1 9.6 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor TFIIF_alpha PF05793.7 CDI79129.1 - 0.96 7.7 20.9 1.4 7.1 14.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNA_polI_A34 PF08208.6 CDI79129.1 - 2 8.0 29.3 0.37 10.4 17.6 1.7 1 1 1 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF2146 PF10220.4 CDI79129.1 - 2.6 5.9 9.4 3.1 5.6 6.5 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) DUF3827 PF12877.2 CDI79129.1 - 3.4 5.6 11.6 3.8 5.4 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Zip PF02535.17 CDI79129.1 - 4 6.3 5.2 3.8 6.4 3.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ETRAMP PF09716.5 CDI79129.1 - 4.3 7.3 9.2 3.8 7.5 6.0 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SspB PF04386.8 CDI79129.1 - 4.7 6.8 6.1 2.3 7.7 2.7 1.6 2 0 0 2 2 2 0 Stringent starvation protein B DUF2201_N PF13203.1 CDI79129.1 - 9.5 5.2 13.7 8.5 5.4 8.9 1.3 1 1 0 1 1 1 0 Putative metallopeptidase domain IncA PF04156.9 CDI79130.1 - 0.033 13.7 1.1 0.033 13.7 0.8 2.6 2 1 1 3 3 3 0 IncA protein Pex14_N PF04695.8 CDI79131.1 - 9.8e-05 22.4 32.2 9.8e-05 22.4 22.3 7.8 4 3 2 6 6 6 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DNA_pol_B PF00136.16 CDI79132.1 - 1.3e-132 442.9 0.7 6.4e-132 440.6 1.1 1.6 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 CDI79132.1 - 2.3e-69 233.7 0.0 3.9e-69 232.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 CDI79132.1 - 3.5e-21 74.9 5.5 7.9e-21 73.8 3.8 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta zf-RING-like PF08746.6 CDI79132.1 - 9.5 6.3 10.4 1.1 9.2 0.8 2.8 2 0 0 2 2 2 0 RING-like domain Mito_carr PF00153.22 CDI79133.1 - 9.1e-58 191.9 0.2 3.3e-20 71.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1192 PF06698.6 CDI79134.1 - 0.083 12.7 0.4 0.18 11.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) ResB PF05140.9 CDI79134.1 - 0.11 10.9 0.1 0.19 10.2 0.1 1.3 1 0 0 1 1 1 0 ResB-like family DUF1469 PF07332.6 CDI79134.1 - 0.4 10.4 4.0 0.23 11.2 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) ACC_epsilon PF13822.1 CDI79134.1 - 1.8 8.9 4.8 0.6 10.5 0.5 2.1 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit PCEMA1 PF07418.6 CDI79136.1 - 0.71 9.1 1.1 1.2 8.4 0.8 1.3 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 OTU PF02338.14 CDI79138.1 - 8.3e-16 58.6 0.0 2e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Nop53 PF07767.6 CDI79138.1 - 0.039 12.9 13.6 0.071 12.0 8.9 1.8 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) SRP9-21 PF05486.7 CDI79141.1 - 1.6e-05 24.5 0.0 3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) SR-25 PF10500.4 CDI79141.1 - 0.58 9.5 8.2 0.68 9.3 5.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Frataxin_Cyay PF01491.11 CDI79142.1 - 3e-10 39.8 0.0 4.7e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Frataxin-like domain LZ_Tnp_IS66 PF13007.2 CDI79142.1 - 0.16 12.6 7.9 0.08 13.5 2.6 2.3 2 1 0 3 3 3 0 Transposase C of IS166 homeodomain AF-4 PF05110.8 CDI79142.1 - 0.89 7.3 12.0 1.3 6.7 8.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Secretin_N_2 PF07655.8 CDI79142.1 - 1.2 9.6 10.5 0.79 10.1 5.9 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain SR-25 PF10500.4 CDI79142.1 - 9.6 5.6 16.5 0.77 9.1 8.2 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Sugar_tr PF00083.19 CDI79143.1 - 8.3e-85 285.0 24.6 1e-84 284.7 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDI79143.1 - 8.9e-36 123.3 56.2 8.9e-26 90.4 22.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nop14 PF04147.7 CDI79144.1 - 0.0051 14.8 0.1 0.011 13.7 0.1 1.4 1 0 0 1 1 1 1 Nop14-like family Clathrin PF00637.15 CDI79145.1 - 3.2e-173 568.2 21.6 2.8e-30 104.8 0.4 7.6 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 CDI79145.1 - 2.5e-25 88.1 0.0 1e-24 86.1 0.0 2.2 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.15 CDI79145.1 - 1.5e-07 31.2 0.0 8.7e-05 22.5 0.0 4.2 5 0 0 5 5 5 1 Clathrin propeller repeat Coatomer_WDAD PF04053.9 CDI79145.1 - 1.3e-05 24.2 5.6 0.19 10.5 0.0 3.7 4 0 0 4 4 4 3 Coatomer WD associated region TPR_1 PF00515.23 CDI79145.1 - 0.83 9.3 5.9 66 3.3 0.2 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 CDI79145.1 - 6.3 7.7 29.0 21 6.0 0.0 10.3 12 0 0 12 12 12 0 Tetratricopeptide repeat CopD PF05425.8 CDI79146.1 - 2.5 8.3 9.4 0.12 12.6 1.0 2.6 3 0 0 3 3 3 0 Copper resistance protein D LSM PF01423.17 CDI79148.1 - 6.7e-18 64.0 0.0 8.4e-18 63.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain NUDIX PF00293.23 CDI79149.1 - 0.015 14.9 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain MRP-L46 PF11788.3 CDI79149.1 - 0.046 14.3 7.7 0.19 12.4 5.4 1.9 1 1 0 1 1 1 0 39S mitochondrial ribosomal protein L46 BRF1 PF07741.8 CDI79149.1 - 0.15 12.2 3.6 0.32 11.2 2.5 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DEAD PF00270.24 CDI79150.1 - 7.4e-42 142.7 0.1 1e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79150.1 - 2.9e-25 87.9 0.1 5.1e-25 87.1 0.1 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI79150.1 - 0.00026 20.8 0.0 0.0016 18.2 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 CDI79150.1 - 0.056 12.5 0.1 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1811 PF08838.5 CDI79150.1 - 0.13 12.2 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) MMR_HSR1 PF01926.18 CDI79151.1 - 9e-30 103.0 0.0 9.7e-20 70.6 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.1 CDI79151.1 - 3.1e-26 91.1 0.0 8.4e-26 89.7 0.0 1.8 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.13 CDI79151.1 - 1.2e-12 47.4 0.0 2.7e-09 36.5 0.0 2.6 3 0 0 3 3 3 2 Ferrous iron transport protein B Dynamin_N PF00350.18 CDI79151.1 - 1.6e-11 44.2 0.3 0.00073 19.4 0.1 3.3 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.22 CDI79151.1 - 7.8e-11 41.7 0.1 8.6e-06 25.3 0.0 3.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.11 CDI79151.1 - 6.8e-08 31.8 0.1 7.3e-05 21.9 0.1 2.4 2 1 0 2 2 2 2 AIG1 family Miro PF08477.8 CDI79151.1 - 2.5e-06 27.9 0.0 1.8e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 CDI79151.1 - 0.00023 20.3 0.0 0.074 12.1 0.0 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region DUF258 PF03193.11 CDI79151.1 - 0.0035 16.5 0.0 0.047 12.8 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Ras PF00071.17 CDI79151.1 - 0.0081 15.5 0.0 0.044 13.1 0.0 2.2 2 1 0 2 2 2 1 Ras family Arf PF00025.16 CDI79151.1 - 0.0082 15.3 0.2 0.11 11.7 0.1 2.5 2 1 0 2 2 2 1 ADP-ribosylation factor family Nuc_deoxyrib_tr PF05014.10 CDI79151.1 - 0.048 13.5 0.0 3.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase UPF0113 PF03657.8 CDI79152.1 - 4.5e-07 29.6 0.0 5.8e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) OmpH PF03938.9 CDI79153.1 - 0.072 13.0 1.6 0.12 12.3 1.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2721 PF11026.3 CDI79153.1 - 0.12 12.0 2.5 0.58 9.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Pkinase PF00069.20 CDI79154.1 - 3.8e-46 157.3 0.0 3.8e-46 157.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79154.1 - 6.8e-27 94.1 0.0 1.2e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI79154.1 - 0.057 13.1 0.1 0.057 13.1 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Prenyltrans PF00432.16 CDI79156.1 - 6.4e-17 60.8 20.5 1.9e-09 36.9 0.1 6.6 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CDI79156.1 - 2.9e-10 40.5 0.2 4.7e-06 26.9 0.0 4.3 3 1 0 3 3 3 1 Prenyltransferase-like CSD PF00313.17 CDI79158.1 - 1.4e-23 82.4 0.3 2e-23 81.9 0.2 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 CDI79158.1 - 0.0019 17.6 0.1 0.0039 16.6 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain S1 PF00575.18 CDI79158.1 - 0.076 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 S1 RNA binding domain PP2C PF00481.16 CDI79160.1 - 2e-26 92.9 0.1 4.8e-16 58.9 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 CDI79160.1 - 3.2e-06 27.0 0.0 6.8e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 CDI79160.1 - 7e-05 22.3 0.0 0.0005 19.5 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C Histone PF00125.19 CDI79165.1 - 3.2e-18 65.6 0.1 4.2e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.8 CDI79165.1 - 0.00025 21.2 0.0 0.00042 20.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.18 CDI79165.1 - 0.0025 17.8 0.1 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Alba PF01918.16 CDI79167.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Alba WD40_alt PF14077.1 CDI79170.1 - 0.0014 18.2 0.3 2.4 7.8 0.0 2.4 2 0 0 2 2 2 2 Alternative WD40 repeat motif HisG PF01634.13 CDI79170.1 - 0.046 13.3 0.0 5.9 6.4 0.0 2.1 2 0 0 2 2 2 0 ATP phosphoribosyltransferase Cu_bind_like PF02298.12 CDI79170.1 - 0.1 12.4 0.1 21 5.0 0.0 2.4 2 0 0 2 2 2 0 Plastocyanin-like domain Asp PF00026.18 CDI79171.1 - 2.3e-39 135.5 3.4 7.2e-23 81.3 0.0 2.6 2 1 1 3 3 3 2 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDI79171.1 - 0.002 18.1 0.2 0.0053 16.7 0.1 1.7 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Pex14_N PF04695.8 CDI79171.1 - 0.082 12.9 12.0 0.19 11.7 8.3 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2370 PF10176.4 CDI79171.1 - 0.56 9.5 6.4 0.97 8.7 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Neur_chan_memb PF02932.11 CDI79171.1 - 0.56 10.0 3.8 0.79 9.5 2.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Glyco_tranf_2_4 PF13704.1 CDI79171.1 - 0.63 10.4 4.6 9.3 6.6 0.0 2.9 2 0 0 2 2 2 0 Glycosyl transferase family 2 Band_3_cyto PF07565.8 CDI79171.1 - 0.95 8.9 10.8 1.5 8.2 7.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAT1 PF09770.4 CDI79171.1 - 3.3 5.8 30.2 4.9 5.2 20.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.2 CDI79171.1 - 3.7 5.0 10.3 5.2 4.6 7.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PRELI PF04707.9 CDI79173.1 - 1.4e-33 115.6 0.0 2.3e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 PRELI-like family SR-25 PF10500.4 CDI79173.1 - 0.56 9.6 11.3 0.071 12.5 3.9 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein tRNA-synt_1b PF00579.20 CDI79176.1 - 5.4e-08 32.3 9.7 1.7e-07 30.6 4.6 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (W and Y) S4 PF01479.20 CDI79176.1 - 6e-05 22.4 0.0 0.00011 21.5 0.0 1.4 1 0 0 1 1 1 1 S4 domain Macoilin PF09726.4 CDI79176.1 - 0.36 9.0 35.4 0.028 12.7 17.0 2.1 2 0 0 2 2 2 0 Transmembrane protein DUF572 PF04502.8 CDI79176.1 - 2.4 7.2 29.4 0.35 10.0 14.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF572) CMV_1a PF12467.3 CDI79176.1 - 2.6 8.4 24.6 0.17 12.2 7.6 2.7 3 0 0 3 3 3 0 Cucumber mosaic virus 1a protein family Na_trans_assoc PF06512.8 CDI79176.1 - 4.2 7.2 24.2 0.54 10.1 12.4 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated vMSA PF00695.14 CDI79176.1 - 5.3 6.1 14.8 10 5.2 10.3 1.4 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Solute_trans_a PF03619.11 CDI79177.1 - 2.3e-32 112.4 1.5 7.2e-23 81.2 0.0 3.1 2 1 1 3 3 3 3 Organic solute transporter Ostalpha DUF1014 PF06244.7 CDI79179.1 - 5.4e-30 104.1 19.7 4.6e-28 97.8 13.6 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) HMG_box PF00505.14 CDI79179.1 - 8.5e-05 22.7 0.3 8.5e-05 22.7 0.2 2.6 2 1 0 2 2 2 1 HMG (high mobility group) box YABBY PF04690.8 CDI79179.1 - 0.011 15.9 1.0 0.011 15.9 0.7 2.2 1 1 1 2 2 2 0 YABBY protein CHDNT PF08073.7 CDI79179.1 - 0.027 14.1 0.1 0.046 13.3 0.1 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain Hira PF07569.6 CDI79179.1 - 0.14 11.3 2.7 0.2 10.8 1.9 1.3 1 0 0 1 1 1 0 TUP1-like enhancer of split TMPIT PF07851.8 CDI79179.1 - 2.2 7.2 5.7 2.8 6.9 3.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein SecD-TM1 PF13721.1 CDI79179.1 - 8.3 6.7 8.8 5.7 7.2 0.3 2.3 2 0 0 2 2 2 0 SecD export protein N-terminal TM region WEMBL PF05701.6 CDI79180.1 - 0.011 14.2 31.3 0.035 12.5 21.7 1.7 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF4201 PF13870.1 CDI79180.1 - 0.94 8.8 20.3 3 7.2 9.6 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Prominin PF05478.6 CDI79180.1 - 1.2 6.6 3.9 1.7 6.1 2.7 1.1 1 0 0 1 1 1 0 Prominin CENP-F_leu_zip PF10473.4 CDI79180.1 - 3.3 7.5 28.2 0.9 9.3 3.1 3.0 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_I PF01496.14 CDI79180.1 - 3.8 5.2 9.7 5.5 4.7 6.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WD40 PF00400.27 CDI79181.1 - 2.1e-11 43.2 8.5 1.4e-06 27.9 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat SR-25 PF10500.4 CDI79182.1 - 0.038 13.4 9.6 0.042 13.3 6.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2973 PF11189.3 CDI79182.1 - 0.098 12.4 1.7 0.11 12.3 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2973) Corona_nucleoca PF00937.13 CDI79182.1 - 0.32 9.8 11.0 0.35 9.7 7.6 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein IncA PF04156.9 CDI79182.1 - 2.9 7.4 13.5 3.7 7.0 9.3 1.3 1 0 0 1 1 1 0 IncA protein Med15 PF09606.5 CDI79182.1 - 3.3 5.8 24.2 4 5.5 16.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI79182.1 - 7.9 4.5 21.9 8.8 4.4 15.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SMAP PF15477.1 CDI79183.1 - 4e-09 36.5 0.0 4e-09 36.5 0.0 9.3 10 0 0 10 10 10 1 Small acidic protein family AP2 PF00847.15 CDI79183.1 - 4.9e-08 32.9 12.0 8.6e-06 25.8 1.9 8.1 9 0 0 9 9 9 3 AP2 domain ACDC PF14733.1 CDI79183.1 - 1.4e-05 25.1 0.4 0.00011 22.2 0.3 2.5 1 1 0 1 1 1 1 AP2-coincident C-terminal RLL PF10036.4 CDI79185.1 - 8.6e-34 117.0 0.2 1.1e-33 116.6 0.1 1.1 1 0 0 1 1 1 1 Putative carnitine deficiency-associated protein DUF2722 PF10846.3 CDI79185.1 - 0.0014 17.7 1.0 0.0015 17.6 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.3 CDI79185.1 - 0.018 14.3 1.1 0.027 13.8 0.7 1.3 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.4 CDI79185.1 - 0.024 12.8 4.9 0.03 12.5 3.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RAB3GAP2_N PF14655.1 CDI79185.1 - 0.086 11.8 2.7 0.12 11.3 1.9 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Suf PF05843.9 CDI79185.1 - 0.093 12.4 2.3 0.13 11.9 1.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF912 PF06024.7 CDI79185.1 - 0.11 12.5 1.5 0.18 11.8 1.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Tom37_C PF11801.3 CDI79185.1 - 0.11 12.3 4.6 0.21 11.4 3.2 1.5 1 0 0 1 1 1 0 Tom37 C-terminal domain FimP PF09766.4 CDI79185.1 - 0.15 11.0 8.6 0.23 10.4 6.0 1.2 1 0 0 1 1 1 0 Fms-interacting protein PGM_PMM_I PF02878.11 CDI79186.1 - 2.6e-11 43.1 0.3 2.3e-06 27.1 0.0 2.8 3 0 0 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PC_rep PF01851.17 CDI79190.1 - 7.5e-08 32.1 3.5 0.22 11.8 0.1 4.6 3 0 0 3 3 3 3 Proteasome/cyclosome repeat PAT1 PF09770.4 CDI79192.1 - 0.00098 17.4 31.5 0.00098 17.4 21.8 2.3 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 TPR_2 PF07719.12 CDI79192.1 - 0.014 15.2 7.8 1.1 9.3 0.3 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SR-25 PF10500.4 CDI79194.1 - 0.0076 15.7 6.2 0.0076 15.7 4.3 5.7 5 1 0 5 5 5 2 Nuclear RNA-splicing-associated protein GTP_EFTU PF00009.22 CDI79196.1 - 8.5e-25 87.2 0.0 2.7e-24 85.6 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI79196.1 - 6.7e-05 22.8 0.0 0.00034 20.5 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF2076 PF09849.4 CDI79196.1 - 0.0019 18.3 22.3 0.0019 18.3 15.5 4.2 4 1 0 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2076) Dynamin_N PF00350.18 CDI79196.1 - 0.002 17.9 0.0 0.002 17.9 0.0 3.8 3 1 1 4 4 4 1 Dynamin family MobB PF03205.9 CDI79196.1 - 0.023 14.4 0.0 0.057 13.1 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 CDI79196.1 - 0.074 13.5 0.0 0.074 13.5 0.0 2.4 3 0 0 3 3 3 0 Miro-like protein TM_helix PF05552.7 CDI79196.1 - 0.15 11.7 0.2 0.15 11.7 0.1 1.9 2 0 0 2 2 2 0 Conserved TM helix Septin PF00735.13 CDI79196.1 - 0.28 10.1 0.0 0.28 10.1 0.0 2.1 2 0 0 2 2 2 0 Septin Plasmodium_Vir PF05795.6 CDI79196.1 - 5.8 6.0 14.8 0.64 9.1 5.0 2.5 3 0 0 3 3 3 0 Plasmodium vivax Vir protein MMS19_N PF14500.1 CDI79198.1 - 2.1e-26 92.7 0.0 2.1e-26 92.7 0.0 3.6 4 0 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II CAF-1_p150 PF11600.3 CDI79198.1 - 0.0036 16.7 7.1 0.0036 16.7 4.9 12.9 13 2 0 13 13 13 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF368 PF04018.8 CDI79198.1 - 0.006 15.8 0.0 0.022 13.9 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF368) RRM_1 PF00076.17 CDI79199.1 - 6.3e-15 54.5 0.1 1.9e-14 53.0 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79199.1 - 2.7e-12 46.4 0.0 6.7e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI79199.1 - 0.0001 22.1 0.0 0.00025 20.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2360 PF10152.4 CDI79199.1 - 0.34 11.1 10.8 0.05 13.8 3.2 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Ndc1_Nup PF09531.5 CDI79199.1 - 4.5 5.5 15.6 7.2 4.9 10.8 1.3 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM60A PF15396.1 CDI79199.1 - 4.8 6.8 24.4 0.56 9.9 2.2 2.1 2 0 0 2 2 2 0 Protein Family FAM60A OKR_DC_1 PF01276.15 CDI79200.1 - 1.4e-71 241.3 0.0 3.5e-53 180.6 0.0 2.2 2 0 0 2 2 2 2 Orn/Lys/Arg decarboxylase, major domain Beta_elim_lyase PF01212.16 CDI79200.1 - 0.00014 21.1 0.0 0.00025 20.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1_C PF03711.10 CDI79200.1 - 0.0038 17.2 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, C-terminal domain E1-E2_ATPase PF00122.15 CDI79202.1 - 4.1e-54 183.0 0.4 1e-53 181.7 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CDI79202.1 - 1.9e-34 118.8 0.9 1.9e-34 118.8 0.6 4.1 5 1 0 5 5 5 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CDI79202.1 - 8.8e-24 85.1 0.0 4.5e-23 82.7 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDI79202.1 - 1.1e-13 51.7 0.0 3.7e-13 50.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDI79202.1 - 2.8e-13 49.6 0.1 6.8e-13 48.3 0.1 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CDI79202.1 - 1.6e-07 30.6 0.0 6.3e-07 28.7 0.0 2.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CDI79202.1 - 0.00016 21.3 0.6 0.0015 18.1 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase MMtag PF10159.4 CDI79203.1 - 1e-16 60.7 2.9 1e-16 60.7 2.0 4.2 4 1 0 4 4 4 1 Kinase phosphorylation protein FUSC_2 PF13515.1 CDI79204.1 - 6.9e-11 42.1 15.0 6.9e-11 42.1 10.4 4.0 3 1 0 3 3 3 1 Fusaric acid resistance protein-like WD40 PF00400.27 CDI79205.1 - 3.7e-06 26.6 0.2 0.00042 20.0 0.2 3.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Foie-gras_1 PF11817.3 CDI79206.1 - 6.9e-10 38.8 0.3 1.4e-09 37.8 0.2 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun PF07919.7 CDI79206.1 - 6.6e-08 31.3 0.0 9.4e-08 30.8 0.0 1.2 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi STT3 PF02516.9 CDI79207.1 - 9.4e-76 255.7 34.6 1.5e-75 255.0 24.0 1.3 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit BT1 PF03092.11 CDI79208.1 - 1.6e-65 221.5 17.1 3.4e-65 220.4 11.8 1.5 1 1 0 1 1 1 1 BT1 family MFS_1 PF07690.11 CDI79208.1 - 2.8e-15 55.8 33.4 3.8e-15 55.4 23.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Prominin PF05478.6 CDI79208.1 - 0.019 12.5 0.4 0.036 11.6 0.3 1.4 1 0 0 1 1 1 0 Prominin Remorin_C PF03763.8 CDI79208.1 - 3 7.4 6.3 0.99 8.9 1.0 2.3 2 1 0 2 2 2 0 Remorin, C-terminal region zf-CDGSH PF09360.5 CDI79209.1 - 4.6e-08 32.7 0.2 4.6e-08 32.7 0.1 1.9 2 0 0 2 2 2 1 Iron-binding zinc finger CDGSH type DUF2076 PF09849.4 CDI79209.1 - 0.15 12.1 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MMR_HSR1 PF01926.18 CDI79210.1 - 2e-19 69.6 0.3 1.1e-15 57.5 0.0 3.1 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.13 CDI79210.1 - 2e-06 27.1 0.1 5.3e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 CDI79210.1 - 0.00065 18.9 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 CDI79210.1 - 0.021 15.3 0.0 0.09 13.2 0.0 2.1 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 CDI79210.1 - 0.023 14.4 0.5 0.18 11.5 0.1 2.5 2 1 1 3 3 3 0 Dynamin family MobB PF03205.9 CDI79210.1 - 0.09 12.4 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Phage_GP20 PF06810.6 CDI79211.1 - 0.0051 16.2 2.0 0.012 15.0 0.3 2.0 2 0 0 2 2 2 1 Phage minor structural protein GP20 PAH PF02671.16 CDI79211.1 - 0.0096 15.5 0.3 0.016 14.7 0.2 1.3 1 0 0 1 1 1 1 Paired amphipathic helix repeat TelA PF05816.6 CDI79211.1 - 0.01 14.5 0.7 0.01 14.5 0.5 1.5 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) Laminin_I PF06008.9 CDI79211.1 - 0.019 14.2 3.9 0.6 9.3 0.5 2.1 2 0 0 2 2 2 0 Laminin Domain I CENP-Q PF13094.1 CDI79211.1 - 0.031 14.3 1.6 0.031 14.3 1.1 1.8 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF2310 PF10071.4 CDI79211.1 - 0.038 12.9 0.1 0.056 12.4 0.1 1.2 1 0 0 1 1 1 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) Med4 PF10018.4 CDI79211.1 - 0.066 12.6 2.3 0.18 11.2 0.5 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Spc7 PF08317.6 CDI79211.1 - 0.11 11.1 2.4 0.15 10.7 0.3 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein Phage_GPO PF05929.6 CDI79211.1 - 0.18 11.0 2.0 0.17 11.1 0.3 1.7 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Prefoldin_2 PF01920.15 CDI79211.1 - 0.2 11.4 5.9 0.66 9.7 1.7 2.3 2 0 0 2 2 2 0 Prefoldin subunit Sec2p PF06428.6 CDI79211.1 - 0.21 11.4 4.3 0.09 12.6 0.5 2.0 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Sec8_exocyst PF04048.9 CDI79211.1 - 0.35 10.5 2.6 0.61 9.7 0.9 1.8 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Prefoldin PF02996.12 CDI79211.1 - 0.68 9.5 5.4 12 5.5 1.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF1192 PF06698.6 CDI79211.1 - 1.3 8.9 9.2 3.3 7.5 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) IncA PF04156.9 CDI79211.1 - 7.1 6.1 8.1 1.9 8.0 2.0 2.0 2 0 0 2 2 2 0 IncA protein Glycoprotein_B PF00606.13 CDI79212.1 - 0.11 10.4 0.6 0.17 9.8 0.4 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B GBA2_N PF12215.3 CDI79212.1 - 0.13 11.4 0.3 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 beta-Glucocerebrosidase 2 N terminal Prominin PF05478.6 CDI79212.1 - 0.13 9.7 1.4 0.19 9.2 1.0 1.1 1 0 0 1 1 1 0 Prominin Plasmid_parti PF01672.11 CDI79212.1 - 0.62 10.5 5.1 1.6 9.1 1.9 2.4 2 0 0 2 2 2 0 Putative plasmid partition protein DUF948 PF06103.6 CDI79212.1 - 0.7 9.7 2.7 3.1 7.7 1.9 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF342 PF03961.8 CDI79212.1 - 1.2 7.4 5.8 2.4 6.4 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF2570 PF10828.3 CDI79212.1 - 3.7 7.1 9.6 0.56 9.8 3.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Bromodomain PF00439.20 CDI79213.1 - 1.1e-08 34.8 0.0 2.5e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 CDI79213.1 - 7.1e-08 32.5 0.2 1.4e-07 31.5 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CDI79213.1 - 1.9e-07 31.0 0.0 4.2e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CDI79213.1 - 0.033 13.9 0.0 0.072 12.8 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.1 CDI79213.1 - 0.074 12.9 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain OmpH PF03938.9 CDI79217.1 - 0.00013 21.9 1.9 0.00013 21.9 1.3 15.5 4 4 4 9 9 9 1 Outer membrane protein (OmpH-like) DUF605 PF04652.11 CDI79218.1 - 0.082 12.2 20.7 0.1 11.9 14.3 1.2 1 0 0 1 1 1 0 Vta1 like MORN PF02493.15 CDI79219.1 - 8.8e-47 154.1 60.5 4e-08 32.5 0.7 9.5 9 0 0 9 9 9 9 MORN repeat TFIIIC_sub6 PF10419.4 CDI79219.1 - 3.3 7.2 8.9 0.92 9.0 0.0 4.0 5 0 0 5 5 5 0 TFIIIC subunit SDF PF00375.13 CDI79221.1 - 0.061 12.0 0.0 0.061 12.0 0.0 1.5 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family Mito_carr PF00153.22 CDI79222.1 - 1e-39 134.1 0.3 1.4e-18 66.3 0.0 4.5 3 1 0 3 3 3 3 Mitochondrial carrier protein PAT1 PF09770.4 CDI79222.1 - 1.6 6.8 16.6 2.3 6.3 11.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MORN PF02493.15 CDI79226.1 - 0.016 14.9 2.3 0.26 11.0 0.0 3.4 4 0 0 4 4 4 0 MORN repeat GTP1_OBG PF01018.17 CDI79227.1 - 1.7e-18 66.7 10.0 2.2e-10 40.3 3.7 2.4 1 1 1 2 2 2 2 GTP1/OBG GTP_EFTU PF00009.22 CDI79227.1 - 0.00023 20.6 0.1 0.062 12.7 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI79227.1 - 0.00028 20.8 0.0 0.0025 17.7 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 CDI79227.1 - 0.0018 17.5 0.1 0.0039 16.4 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 CDI79227.1 - 0.037 14.5 0.0 25 5.4 0.0 3.1 3 0 0 3 3 3 0 Miro-like protein ATP_bind_1 PF03029.12 CDI79227.1 - 0.044 13.3 0.3 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF1967 PF09269.6 CDI79227.1 - 0.082 12.5 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) G-alpha PF00503.15 CDI79227.1 - 0.1 11.2 0.5 0.26 9.9 0.0 1.8 2 1 0 2 2 2 0 G-protein alpha subunit IMS PF00817.15 CDI79230.1 - 6.2e-39 133.1 0.1 1.8e-38 131.6 0.1 1.9 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 CDI79230.1 - 1.8e-14 53.7 0.4 4.9e-14 52.3 0.3 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 CDI79230.1 - 0.00061 19.6 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif Folate_rec PF03024.9 CDI79231.1 - 6.1e-07 29.2 0.7 9.8e-07 28.5 0.5 1.3 1 0 0 1 1 1 1 Folate receptor family MORN PF02493.15 CDI79233.1 - 7.6e-12 44.2 9.8 0.00036 20.0 0.0 5.4 5 0 0 5 5 5 4 MORN repeat AP2 PF00847.15 CDI79233.1 - 0.065 13.4 0.3 0.17 12.0 0.2 1.6 1 0 0 1 1 1 0 AP2 domain BTK PF00779.14 CDI79236.1 - 0.089 12.4 0.4 0.16 11.6 0.2 1.4 1 0 0 1 1 1 0 BTK motif Post_transc_reg PF13797.1 CDI79237.1 - 0.028 14.0 0.1 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Post-transcriptional regulator NDK PF00334.14 CDI79239.1 - 1.9e-05 24.4 0.0 0.016 14.9 0.0 2.7 2 1 0 2 2 2 2 Nucleoside diphosphate kinase Activator_LAG-3 PF11498.3 CDI79241.1 - 0.26 9.9 17.4 0.33 9.6 12.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ATP-synt_Eps PF04627.8 CDI79242.1 - 0.0092 15.5 0.1 0.0092 15.5 0.1 2.3 2 1 0 2 2 2 1 Mitochondrial ATP synthase epsilon chain Surp PF01805.15 CDI79243.1 - 1.9e-11 43.3 0.1 3.5e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 Surp module cwf21 PF08312.7 CDI79243.1 - 3.9e-11 42.6 4.9 3.9e-11 42.6 3.4 2.5 2 0 0 2 2 2 1 cwf21 domain RRM_1 PF00076.17 CDI79243.1 - 2.8e-05 23.6 0.2 7.9e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.3 CDI79243.1 - 0.00032 20.3 0.0 0.00066 19.3 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 RRM_6 PF14259.1 CDI79243.1 - 0.17 11.8 0.4 0.56 10.2 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Tubulin PF00091.20 CDI79244.1 - 1.9e-14 54.0 0.0 9.2e-07 28.8 0.0 2.5 3 0 0 3 3 3 2 Tubulin/FtsZ family, GTPase domain E1-E2_ATPase PF00122.15 CDI79245.1 - 9.8e-48 162.1 1.7 2.2e-47 161.0 0.3 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 CDI79245.1 - 3.5e-25 89.6 0.2 7.5e-25 88.6 0.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDI79245.1 - 3.7e-11 43.5 0.0 9.4e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CDI79245.1 - 3.2e-07 29.6 0.1 0.0056 16.1 0.0 2.7 2 0 0 2 2 2 2 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 CDI79245.1 - 0.00029 20.7 0.0 0.00071 19.4 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CDI79245.1 - 0.0027 17.3 0.1 0.0053 16.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EF-hand_7 PF13499.1 CDI79246.1 - 1.1e-14 54.3 0.0 2e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI79246.1 - 7.3e-14 49.9 0.0 1.3e-06 27.2 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 CDI79246.1 - 2.9e-12 45.3 0.0 2.9e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 CDI79246.1 - 1.1e-09 37.7 0.0 5.9e-07 29.0 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 CDI79246.1 - 1.5e-09 36.7 0.0 2.2e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 CDI79246.1 - 0.00031 20.7 0.0 0.00042 20.3 0.0 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.5 CDI79246.1 - 0.11 12.4 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Ca2+ insensitive EF hand His_Phos_2 PF00328.17 CDI79248.1 - 4.5e-06 26.2 0.3 4.5e-06 26.2 0.2 3.7 4 0 0 4 4 4 1 Histidine phosphatase superfamily (branch 2) DUF3682 PF12446.3 CDI79248.1 - 6.7e-05 23.2 22.0 6.7e-05 23.2 15.3 14.7 10 3 5 15 15 15 1 Protein of unknown function (DUF3682) SR-25 PF10500.4 CDI79248.1 - 0.0011 18.4 6.4 0.0011 18.4 4.4 7.9 6 2 2 8 8 8 2 Nuclear RNA-splicing-associated protein BRF1 PF07741.8 CDI79248.1 - 0.0062 16.7 1.0 0.0062 16.7 0.7 7.0 7 1 0 7 7 7 1 Brf1-like TBP-binding domain DUF4131 PF13567.1 CDI79249.1 - 0.062 12.6 4.7 0.064 12.6 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Glyco_transf_15 PF01793.11 CDI79249.1 - 2.6 6.9 8.8 2.9 6.7 6.1 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase DUF2749 PF10907.3 CDI79249.1 - 8.2 6.3 8.8 3.3 7.6 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2749) Pkinase PF00069.20 CDI79250.1 - 4e-26 91.7 0.8 8.1e-16 57.9 0.0 5.4 5 0 0 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79250.1 - 8e-11 41.4 0.0 8.6e-08 31.5 0.0 3.5 3 0 0 3 3 3 2 Protein tyrosine kinase Med15 PF09606.5 CDI79250.1 - 0.00023 19.5 52.1 0.00023 19.5 36.1 10.6 7 2 3 10 10 10 1 ARC105 or Med15 subunit of Mediator complex non-fungal PQQ PF01011.16 CDI79250.1 - 0.12 11.9 1.9 3.2 7.4 0.0 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat Pox_ser-thr_kin PF05445.6 CDI79250.1 - 6.3 5.4 0.0 9.7 4.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ribosomal_L21p PF00829.16 CDI79254.1 - 8.9e-15 54.6 0.0 1.2e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein DUF793 PF05633.6 CDI79255.1 - 0.4 9.3 3.3 0.98 8.1 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF793) R_equi_Vir PF05526.6 CDI79255.1 - 1.9 8.1 7.9 0.99 9.0 2.2 2.8 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein Spt20 PF12090.3 CDI79256.1 - 0.0095 15.2 3.9 0.065 12.5 1.6 2.3 2 0 0 2 2 2 1 Spt20 family FimP PF09766.4 CDI79256.1 - 0.018 14.0 5.1 0.031 13.3 3.6 1.3 1 0 0 1 1 1 0 Fms-interacting protein RAB3GAP2_N PF14655.1 CDI79256.1 - 0.082 11.9 2.6 0.14 11.1 1.8 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Corona_nucleoca PF00937.13 CDI79256.1 - 0.57 9.0 26.5 1.3 7.9 3.4 2.2 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein GlcNAc PF11397.3 CDI79256.1 - 2.5 7.1 5.2 5.1 6.0 2.9 1.8 2 0 0 2 2 2 0 Glycosyltransferase (GlcNAc) PAT1 PF09770.4 CDI79256.1 - 3.9 5.5 28.0 5.2 5.1 19.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AUX_IAA PF02309.11 CDI79256.1 - 7 6.3 11.0 0.47 10.1 1.8 2.2 2 0 0 2 2 2 0 AUX/IAA family Ank_2 PF12796.2 CDI79258.1 - 5.8e-14 52.2 3.2 5.4e-07 29.8 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 CDI79258.1 - 4.4e-12 45.1 4.9 0.0028 17.4 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 CDI79258.1 - 2.9e-10 39.3 0.5 0.0059 16.7 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 CDI79258.1 - 1.6e-05 25.2 0.5 6.6 7.3 0.1 4.7 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDI79258.1 - 0.017 15.3 3.1 5.7 7.3 0.0 4.3 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Abi PF02517.11 CDI79259.1 - 1e-06 28.7 11.3 2.6e-06 27.4 0.7 3.7 3 1 0 3 3 3 2 CAAX protease self-immunity DUF2217 PF10265.4 CDI79261.1 - 0.13 11.0 8.3 0.14 10.8 5.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF3365 PF11845.3 CDI79261.1 - 0.31 10.8 3.4 0.32 10.8 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) SpoIIIAH PF12685.2 CDI79261.1 - 1.6 8.1 9.2 1.8 7.9 6.4 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Macoilin PF09726.4 CDI79262.1 - 0.11 10.7 23.0 0.14 10.4 16.0 1.0 1 0 0 1 1 1 0 Transmembrane protein Spc7_N PF15402.1 CDI79262.1 - 9.8 4.0 16.4 12 3.7 11.4 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 IncA PF04156.9 CDI79263.1 - 2.3e-06 27.3 13.3 4.4e-06 26.4 9.2 1.5 1 0 0 1 1 1 1 IncA protein DUF1517 PF07466.6 CDI79263.1 - 0.0019 17.2 6.7 0.0019 17.2 4.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1517) Macoilin PF09726.4 CDI79263.1 - 0.0069 14.7 22.7 0.0078 14.5 15.7 1.0 1 0 0 1 1 1 1 Transmembrane protein Potyvirid-P3 PF13608.1 CDI79263.1 - 2.9 6.8 8.8 4.2 6.3 6.1 1.2 1 1 0 1 1 1 0 Protein P3 of Potyviral polyprotein O-antigen_lig PF13425.1 CDI79263.1 - 3.1 7.7 5.8 5.6 6.9 4.0 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Secretin_N_2 PF07655.8 CDI79263.1 - 8.8 6.7 25.3 0.22 11.9 12.3 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain PRT_C PF08372.5 CDI79265.1 - 0.09 12.2 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal EF-hand_1 PF00036.27 CDI79266.1 - 7.4e-07 28.0 0.7 0.0055 15.9 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 CDI79266.1 - 1.1e-05 25.4 0.0 4.4e-05 23.5 0.0 2.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 CDI79266.1 - 0.00011 21.6 0.3 0.034 13.7 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI79266.1 - 0.00016 21.2 1.4 0.29 11.1 0.2 3.0 2 0 0 2 2 2 2 EF-hand domain DUF374 PF04028.8 CDI79266.1 - 0.0054 15.9 0.2 0.022 14.0 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF374) FimP PF09766.4 CDI79266.1 - 0.31 10.0 20.4 0.49 9.3 5.1 3.1 3 0 0 3 3 3 0 Fms-interacting protein NHase_beta PF02211.10 CDI79266.1 - 0.51 10.0 7.7 0.27 10.9 0.8 2.3 2 0 0 2 2 2 0 Nitrile hydratase beta subunit EF-hand_10 PF14788.1 CDI79266.1 - 4.3 7.0 5.7 22 4.8 0.4 3.1 3 0 0 3 3 3 0 EF hand DUF4220 PF13968.1 CDI79266.1 - 4.6 6.2 11.6 4 6.4 0.1 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4220) Rpp20 PF12328.3 CDI79266.1 - 5.1 6.7 11.8 4.3 6.9 1.2 3.5 3 0 0 3 3 3 0 Rpp20 subunit of nuclear RNase MRP and P Neur_chan_memb PF02932.11 CDI79266.1 - 5.8 6.7 13.1 2.1 8.1 0.2 2.5 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region F-protein PF00469.15 CDI79266.1 - 7.3 5.8 10.2 6 6.1 0.3 2.9 3 0 0 3 3 3 0 Negative factor, (F-Protein) or Nef Glyco_hydro_19 PF00182.14 CDI79267.1 - 6.6e-10 39.0 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Chitinase class I Pex14_N PF04695.8 CDI79267.1 - 0.26 11.3 7.2 0.9 9.5 5.0 1.9 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.4 CDI79267.1 - 0.37 8.9 10.8 0.63 8.2 7.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PFU PF09070.6 CDI79268.1 - 3e-12 46.5 0.2 3.4e-10 39.9 0.2 2.9 1 1 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 CDI79268.1 - 7.8e-10 38.2 13.0 0.0012 18.5 0.4 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat PUL PF08324.6 CDI79268.1 - 1.5e-06 27.1 0.1 1.5e-06 27.1 0.0 2.6 2 1 1 3 3 3 2 PUL domain DUF3357 PF11837.3 CDI79268.1 - 0.017 14.9 5.9 0.11 12.3 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) AIF_C PF14721.1 CDI79268.1 - 0.46 10.7 0.0 0.46 10.7 0.0 2.7 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Glyco_hydro_35 PF01301.14 CDI79270.1 - 0.29 10.4 0.3 0.51 9.6 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 JAB PF01398.16 CDI79271.1 - 0.017 14.8 1.1 0.029 14.1 0.0 2.0 2 0 0 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DMP1 PF07263.6 CDI79274.1 - 0.026 13.2 0.2 0.028 13.1 0.1 1.0 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) Rhabdo_glycop PF00974.13 CDI79275.1 - 0.085 11.0 0.1 0.11 10.6 0.1 1.1 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Hydant_A_N PF05378.8 CDI79276.1 - 0.0068 15.9 1.7 0.02 14.3 0.2 2.0 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Tme5_EGF_like PF09064.5 CDI79279.1 - 0.091 12.3 0.8 0.2 11.2 0.5 1.5 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like Ant_C PF05586.6 CDI79280.1 - 0.12 12.8 0.4 0.21 12.0 0.3 1.4 1 0 0 1 1 1 0 Anthrax receptor C-terminus region Zip PF02535.17 CDI79280.1 - 0.12 11.3 2.1 0.17 10.8 1.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Claudin_2 PF13903.1 CDI79280.1 - 0.13 11.8 0.4 0.23 11.1 0.2 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction RskA PF10099.4 CDI79280.1 - 0.31 10.7 15.2 0.074 12.7 7.8 1.8 2 0 0 2 2 2 0 Anti-sigma-K factor rskA RNA_pol_Rpc4 PF05132.9 CDI79280.1 - 1.2 9.0 4.0 12 5.8 0.2 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 FNIP_N PF14636.1 CDI79280.1 - 1.3 9.4 14.4 0.71 10.3 2.2 2.1 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus Trns_repr_metal PF02583.12 CDI79280.1 - 1.4 9.1 6.8 2.6 8.2 4.7 1.4 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor Hamartin PF04388.7 CDI79280.1 - 4.9 5.7 15.2 5.6 5.5 10.5 1.0 1 0 0 1 1 1 0 Hamartin protein PAT1 PF09770.4 CDI79280.1 - 4.9 5.2 13.6 5.5 5.0 9.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI79280.1 - 6.8 6.4 17.0 10 5.9 11.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.20 CDI79281.1 - 1.8e-36 125.5 0.0 7.9e-35 120.2 0.0 2.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79281.1 - 1.6e-31 109.3 0.0 1.1e-29 103.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase RAP PF08373.5 CDI79282.1 - 5.2e-13 48.5 0.0 5.2e-13 48.5 0.0 2.4 2 0 0 2 2 2 1 RAP domain TT_ORF1 PF02956.9 CDI79282.1 - 0.17 10.2 13.3 0.28 9.5 1.4 2.1 2 0 0 2 2 2 0 TT viral orf 1 DDHD PF02862.12 CDI79282.1 - 0.33 10.7 25.7 1.3 8.7 5.8 2.4 2 0 0 2 2 2 0 DDHD domain Rtf2 PF04641.7 CDI79282.1 - 0.38 9.9 22.0 0.074 12.2 0.3 2.5 2 0 0 2 2 2 0 Rtf2 RING-finger Anoctamin PF04547.7 CDI79282.1 - 2.3 6.7 11.4 3.6 6.1 1.8 2.2 2 0 0 2 2 2 0 Calcium-activated chloride channel Folate_carrier PF01770.13 CDI79282.1 - 4.9 5.5 13.2 5.3 5.4 1.3 2.6 2 0 0 2 2 2 0 Reduced folate carrier FAM60A PF15396.1 CDI79282.1 - 7.6 6.2 24.1 0.85 9.3 5.6 2.4 2 0 0 2 2 2 0 Protein Family FAM60A DUF2127 PF09900.4 CDI79283.1 - 0.29 11.1 2.5 0.67 9.9 0.1 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2127) Apc3 PF12895.2 CDI79284.1 - 1.1e-05 25.4 0.0 3.4e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Mitofilin PF09731.4 CDI79284.1 - 0.00052 18.8 18.2 0.00058 18.6 12.6 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein TPR_6 PF13174.1 CDI79284.1 - 0.0034 17.7 0.0 9.2 6.9 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Herpes_gE PF02480.11 CDI79284.1 - 0.023 12.9 4.6 0.04 12.2 3.2 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF966 PF06136.8 CDI79284.1 - 0.041 13.3 33.7 0.068 12.5 21.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF966) AvrE PF11725.3 CDI79284.1 - 0.54 7.2 22.8 0.58 7.1 15.8 1.1 1 0 0 1 1 1 0 Pathogenicity factor Shadoo PF14999.1 CDI79284.1 - 0.68 9.7 16.0 1.4 8.8 5.1 2.4 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF4175 PF13779.1 CDI79284.1 - 0.82 7.2 38.5 1.1 6.8 26.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) MCPVI PF02993.9 CDI79284.1 - 1.1 9.3 16.9 2.2 8.3 11.7 1.4 1 0 0 1 1 1 0 Minor capsid protein VI Ycf1 PF05758.7 CDI79284.1 - 1.3 6.6 13.2 1.6 6.3 9.1 1.1 1 0 0 1 1 1 0 Ycf1 LCD1 PF09798.4 CDI79284.1 - 2 6.2 20.8 2.7 5.8 14.4 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF4647 PF15504.1 CDI79284.1 - 3.1 6.5 26.1 5.1 5.8 18.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DDRGK PF09756.4 CDI79284.1 - 7.2 5.9 22.5 12 5.2 15.6 1.2 1 0 0 1 1 1 0 DDRGK domain Alg14 PF08660.6 CDI79286.1 - 7.5e-11 42.3 0.2 7.5e-11 42.3 0.1 4.3 3 2 2 5 5 4 1 Oligosaccharide biosynthesis protein Alg14 like CDC45 PF02724.9 CDI79286.1 - 0.00015 19.9 11.1 0.00015 19.9 7.7 3.1 3 0 0 3 3 3 1 CDC45-like protein FimP PF09766.4 CDI79286.1 - 0.0014 17.7 15.0 0.0014 17.7 10.4 5.1 3 1 1 4 4 3 2 Fms-interacting protein Peroxin-13_N PF04088.8 CDI79286.1 - 0.0021 18.0 4.4 0.0021 18.0 3.0 4.7 4 1 0 4 4 3 1 Peroxin 13, N-terminal region DUF1510 PF07423.6 CDI79286.1 - 0.0094 15.3 13.5 0.0094 15.3 9.4 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF1510) DUF4337 PF14235.1 CDI79286.1 - 0.016 15.0 1.8 0.016 15.0 1.2 4.3 3 1 1 4 4 1 0 Domain of unknown function (DUF4337) Gti1_Pac2 PF09729.4 CDI79286.1 - 0.053 13.4 0.2 0.053 13.4 0.1 4.1 3 1 0 3 3 2 0 Gti1/Pac2 family Packaging_FI PF14000.1 CDI79286.1 - 0.09 12.9 0.3 0.09 12.9 0.2 4.5 4 1 0 4 4 3 0 DNA packaging protein FI Ureide_permease PF07168.6 CDI79286.1 - 0.31 9.6 4.5 4.1 5.9 1.0 2.3 2 0 0 2 2 2 0 Ureide permease Spore_coat_CotO PF14153.1 CDI79286.1 - 0.33 10.3 70.0 0.067 12.6 8.3 4.1 4 0 0 4 4 4 0 Spore coat protein CotO SDA1 PF05285.7 CDI79286.1 - 0.83 8.8 40.2 0.095 11.9 5.4 3.5 3 1 0 3 3 3 0 SDA1 BLVR PF06375.6 CDI79286.1 - 8.1 6.2 38.0 1.4 8.7 1.3 4.2 4 0 0 4 4 4 0 Bovine leukaemia virus receptor (BLVR) PCI PF01399.22 CDI79287.1 - 2.6e-13 50.2 0.1 4.7e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 PCI domain Paf67 PF10255.4 CDI79287.1 - 0.022 13.6 1.7 0.029 13.2 1.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 RR_TM4-6 PF06459.7 CDI79288.1 - 0.00019 21.4 22.6 0.00023 21.1 15.7 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Dsh_C PF12316.3 CDI79288.1 - 0.00051 20.2 6.5 0.00059 20.0 4.5 1.1 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal CDC45 PF02724.9 CDI79288.1 - 0.0018 16.4 18.6 0.0019 16.2 12.9 1.0 1 0 0 1 1 1 1 CDC45-like protein Ycf1 PF05758.7 CDI79288.1 - 0.0029 15.4 21.8 0.0031 15.3 15.1 1.0 1 0 0 1 1 1 1 Ycf1 SAGA-Tad1 PF12767.2 CDI79288.1 - 0.0035 17.0 22.3 0.0043 16.7 15.4 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit CAF-1_p150 PF11600.3 CDI79288.1 - 0.0066 15.8 30.9 0.0086 15.4 21.4 1.1 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal SpaB_C PF14028.1 CDI79288.1 - 0.015 14.8 2.2 0.016 14.7 1.5 1.1 1 0 0 1 1 1 0 SpaB C-terminal domain TFIIA PF03153.8 CDI79288.1 - 0.027 14.4 43.2 0.033 14.0 29.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOBP PF15279.1 CDI79288.1 - 0.029 14.7 19.6 0.035 14.4 13.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF605 PF04652.11 CDI79288.1 - 0.031 13.6 29.2 0.037 13.4 20.2 1.2 1 0 0 1 1 1 0 Vta1 like Daxx PF03344.10 CDI79288.1 - 0.037 12.5 25.5 0.043 12.3 17.7 1.0 1 0 0 1 1 1 0 Daxx Family Spore_coat_CotO PF14153.1 CDI79288.1 - 0.041 13.3 35.8 0.052 12.9 24.8 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DDHD PF02862.12 CDI79288.1 - 0.061 13.1 21.9 0.1 12.3 15.2 1.4 1 0 0 1 1 1 0 DDHD domain FAM60A PF15396.1 CDI79288.1 - 0.077 12.7 20.4 0.098 12.3 14.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A PTPlike_phytase PF14566.1 CDI79288.1 - 0.086 12.8 11.0 0.11 12.5 7.6 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF4661 PF15576.1 CDI79288.1 - 0.091 12.3 4.7 0.12 11.9 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) SAPS PF04499.10 CDI79288.1 - 0.092 11.3 21.2 0.11 11.0 14.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.2 CDI79288.1 - 0.1 10.2 25.8 0.11 10.1 17.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4045 PF13254.1 CDI79288.1 - 0.12 11.6 23.1 0.14 11.4 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Pox_Ag35 PF03286.9 CDI79288.1 - 0.12 11.8 18.6 0.15 11.5 12.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PAT1 PF09770.4 CDI79288.1 - 0.3 9.2 57.2 0.37 8.9 39.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tim54 PF11711.3 CDI79288.1 - 0.32 9.5 17.2 0.5 8.9 11.9 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Med19 PF10278.4 CDI79288.1 - 0.43 10.2 16.9 0.52 9.9 11.7 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Adeno_hexon PF01065.14 CDI79288.1 - 0.49 9.1 16.0 0.68 8.7 11.1 1.2 1 0 0 1 1 1 0 Hexon, adenovirus major coat protein, N-terminal domain DUF2146 PF10220.4 CDI79288.1 - 0.5 8.2 21.2 0.58 8.0 14.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Herpes_UL87 PF03043.9 CDI79288.1 - 0.91 7.8 11.9 0.99 7.7 8.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL87 family Calici_coat_C PF08435.6 CDI79288.1 - 1 8.5 16.6 1.4 8.1 11.5 1.1 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal GAGA_bind PF06217.7 CDI79288.1 - 1 9.2 26.1 1.3 8.9 18.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF853 PF05872.7 CDI79288.1 - 1.3 7.3 17.4 1.9 6.7 12.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Membralin PF09746.4 CDI79288.1 - 1.5 7.7 11.4 1.7 7.5 7.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein Raftlin PF15250.1 CDI79288.1 - 1.8 6.9 27.0 2.3 6.6 18.7 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.12 CDI79288.1 - 1.9 7.2 18.9 2.3 6.9 13.1 1.1 1 0 0 1 1 1 0 Presenilin DUF342 PF03961.8 CDI79288.1 - 2 6.7 18.6 2.3 6.5 12.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) VID27 PF08553.5 CDI79288.1 - 2.1 6.4 19.9 2.4 6.2 13.8 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein PPP4R2 PF09184.6 CDI79288.1 - 2.2 7.7 26.7 2.9 7.3 18.5 1.1 1 0 0 1 1 1 0 PPP4R2 Utp14 PF04615.8 CDI79288.1 - 2.2 6.3 35.7 2.7 6.0 24.8 1.0 1 0 0 1 1 1 0 Utp14 protein Vfa1 PF08432.5 CDI79288.1 - 3.2 7.7 31.2 4.3 7.3 21.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Spc7_N PF15402.1 CDI79288.1 - 3.4 5.5 28.8 4.6 5.1 19.9 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF966 PF06136.8 CDI79288.1 - 3.5 6.9 23.5 4.5 6.5 16.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SID-1_RNA_chan PF13965.1 CDI79288.1 - 4 5.4 16.4 4.6 5.2 11.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Mem_trans PF03547.13 CDI79288.1 - 4 5.6 12.4 4.7 5.3 8.6 1.1 1 0 0 1 1 1 0 Membrane transport protein FLO_LFY PF01698.11 CDI79288.1 - 4 6.1 29.5 5.1 5.8 20.4 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein AUX_IAA PF02309.11 CDI79288.1 - 4.2 7.0 24.7 6.1 6.5 17.1 1.2 1 0 0 1 1 1 0 AUX/IAA family DUF913 PF06025.7 CDI79288.1 - 4.4 5.9 17.0 6.9 5.3 11.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AvrE PF11725.3 CDI79288.1 - 4.7 4.1 29.2 5.5 3.8 20.2 1.0 1 0 0 1 1 1 0 Pathogenicity factor DUF1510 PF07423.6 CDI79288.1 - 4.7 6.5 37.7 6.2 6.1 26.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FMN_dh PF01070.13 CDI79288.1 - 4.7 5.9 11.5 6.8 5.4 8.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase eIF-3_zeta PF05091.7 CDI79288.1 - 4.9 5.6 34.8 6.1 5.3 24.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) eIF3_subunit PF08597.5 CDI79288.1 - 5.1 6.5 30.3 7.3 6.0 21.0 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit RNA_pol_Rpb1_5 PF04998.12 CDI79288.1 - 5.8 6.0 18.9 7.3 5.7 13.1 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Cellulose_synt PF03552.9 CDI79288.1 - 5.8 5.0 12.8 7 4.8 8.8 1.1 1 0 0 1 1 1 0 Cellulose synthase LMBR1 PF04791.11 CDI79288.1 - 5.8 5.3 14.8 6.6 5.2 10.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein GBP_C PF02841.9 CDI79288.1 - 6 5.9 42.0 8.5 5.4 29.1 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain APG6 PF04111.7 CDI79288.1 - 6.5 5.7 35.6 8.3 5.3 24.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Asp-B-Hydro_N PF05279.6 CDI79288.1 - 6.5 6.5 24.7 8.5 6.1 17.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region MMR1 PF08505.5 CDI79288.1 - 6.8 6.6 34.2 11 5.9 23.7 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NARP1 PF12569.3 CDI79288.1 - 7 5.2 28.9 9.3 4.8 20.1 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4220 PF13968.1 CDI79288.1 - 8 5.4 14.3 10 5.1 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF2201_N PF13203.1 CDI79288.1 - 8.3 5.4 31.6 10 5.1 21.9 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain PA26 PF04636.8 CDI79288.1 - 8.3 4.9 19.0 9.8 4.7 13.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) tRNA-synt_2c PF01411.14 CDI79288.1 - 8.3 4.5 17.7 12 4.0 12.3 1.2 1 0 0 1 1 1 0 tRNA synthetases class II (A) DHHW PF14286.1 CDI79288.1 - 8.3 5.6 26.8 11 5.2 18.5 1.1 1 0 0 1 1 1 0 DHHW protein Peptidase_S64 PF08192.6 CDI79288.1 - 9.1 4.4 20.7 11 4.2 14.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 BTV_NS2 PF04514.7 CDI79288.1 - 9.2 5.0 27.3 12 4.6 18.9 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Rtf2 PF04641.7 CDI79288.1 - 10 5.2 30.8 13 4.9 21.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger tRNA_anti-codon PF01336.20 CDI79289.1 - 0.00023 20.9 0.0 0.037 13.8 0.0 2.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Med15 PF09606.5 CDI79289.1 - 0.01 14.0 16.7 0.017 13.4 11.6 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RbsD_FucU PF05025.8 CDI79289.1 - 0.041 14.1 1.1 0.072 13.4 0.7 1.3 1 0 0 1 1 1 0 RbsD / FucU transport protein family AAA_23 PF13476.1 CDI79289.1 - 0.098 12.9 2.0 0.13 12.5 1.4 1.2 1 0 0 1 1 1 0 AAA domain Activator_LAG-3 PF11498.3 CDI79289.1 - 2.3 6.9 21.0 3.2 6.4 14.6 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2890 PF11081.3 CDI79290.1 - 1.2 9.1 8.6 2 8.4 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) DUF3827 PF12877.2 CDI79290.1 - 4.9 5.1 5.1 6.7 4.6 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Biotin_lipoyl PF00364.17 CDI79291.1 - 6.7e-21 73.7 0.6 1e-20 73.1 0.4 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF2638 PF10937.3 CDI79291.1 - 4.1e-05 24.5 0.8 4.1e-05 24.5 0.6 4.2 4 2 0 4 4 4 1 Protein of unknown function (DUF2638) Biotin_lipoyl_2 PF13533.1 CDI79291.1 - 0.03 13.9 9.5 0.072 12.7 0.0 3.0 2 1 1 3 3 3 0 Biotin-lipoyl like HlyD_2 PF12700.2 CDI79291.1 - 0.12 11.5 1.4 1.6 7.7 0.0 2.6 1 1 1 2 2 2 0 HlyD family secretion protein tRNA-synt_1b PF00579.20 CDI79295.1 - 1e-32 113.4 0.1 1.9e-31 109.2 0.1 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) SR-25 PF10500.4 CDI79295.1 - 0.024 14.1 0.1 0.024 14.1 0.1 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DEAD PF00270.24 CDI79296.1 - 1.6e-39 135.0 2.4 7.9e-38 129.5 0.1 2.7 2 1 0 2 2 2 2 DEAD/DEAH box helicase SR-25 PF10500.4 CDI79296.1 - 0.053 12.9 13.4 0.28 10.6 2.6 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CMS1 PF14617.1 CDI79296.1 - 0.18 10.8 0.0 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit GCC2_GCC3 PF07699.8 CDI79297.1 - 2.5e-14 52.5 334.3 0.00011 21.7 1.9 32.3 22 8 8 30 30 30 20 GCC2 and GCC3 DUF4188 PF13826.1 CDI79297.1 - 2.4 8.2 0.0 6.2 6.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) tRNA-synt_1e PF01406.14 CDI79297.1 - 6.1 5.8 2.4 3.8 6.5 0.2 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain cNMP_binding PF00027.24 CDI79300.1 - 2.4e-12 46.4 0.1 1.1e-06 28.3 0.0 3.5 2 2 0 2 2 2 2 Cyclic nucleotide-binding domain INTS5_N PF14837.1 CDI79301.1 - 0.084 12.2 7.0 0.077 12.4 1.3 2.3 2 0 0 2 2 2 0 Integrator complex subunit 5 N-terminus Dpy-30 PF05186.8 CDI79301.1 - 0.42 10.1 0.1 0.42 10.1 0.0 3.1 4 0 0 4 4 4 0 Dpy-30 motif DDHD PF02862.12 CDI79301.1 - 3.1 7.5 19.8 0.63 9.7 3.8 2.6 2 1 0 2 2 2 0 DDHD domain Ctr PF04145.10 CDI79301.1 - 4.4 7.3 15.7 8 6.5 3.4 3.5 3 1 0 3 3 3 0 Ctr copper transporter family DUF4011 PF13195.1 CDI79301.1 - 6.7 6.7 13.9 2.9 7.8 1.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4011) PPP4R2 PF09184.6 CDI79301.1 - 6.8 6.1 20.5 0.27 10.7 4.6 2.3 2 0 0 2 2 2 0 PPP4R2 VIT1 PF01988.14 CDI79302.1 - 0.00032 20.2 3.9 0.00032 20.2 2.7 9.8 12 2 0 12 12 12 1 VIT family DUF605 PF04652.11 CDI79303.1 - 0.21 10.9 10.9 0.23 10.8 7.6 1.1 1 0 0 1 1 1 0 Vta1 like Med15 PF09606.5 CDI79304.1 - 0.00027 19.2 47.8 0.00042 18.6 33.1 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_23 PF13476.1 CDI79304.1 - 0.38 11.0 24.8 4.1e+03 -2.2 17.2 2.5 1 1 0 1 1 1 0 AAA domain Proteasome PF00227.21 CDI79305.1 - 4.5e-46 156.5 0.1 7.5e-46 155.8 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit zf-met PF12874.2 CDI79307.1 - 0.00011 22.2 1.8 0.00019 21.4 1.2 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CDI79307.1 - 0.00013 22.0 1.2 0.00024 21.1 0.9 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.7 CDI79307.1 - 0.26 10.8 0.9 0.53 9.8 0.6 1.4 1 0 0 1 1 1 0 U1 zinc finger DUF4650 PF15509.1 CDI79309.1 - 3.3 6.5 7.7 4.3 6.1 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) Utp14 PF04615.8 CDI79310.1 - 2.7 6.0 13.3 3 5.9 9.2 1.2 1 0 0 1 1 1 0 Utp14 protein Hid1 PF12722.2 CDI79310.1 - 5.2 4.6 18.8 6.2 4.3 13.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AP2 PF00847.15 CDI79311.1 - 4.8e-05 23.4 0.1 4.8e-05 23.4 0.0 4.4 4 0 0 4 4 4 1 AP2 domain zf-RING_2 PF13639.1 CDI79313.1 - 1.8e-08 34.0 1.9 2.5e-08 33.5 1.3 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDI79313.1 - 3.1e-06 27.1 2.4 5.2e-06 26.4 1.7 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CDI79313.1 - 1.4e-05 24.6 1.6 2.1e-05 24.0 1.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI79313.1 - 0.00074 19.4 1.7 0.0011 18.9 1.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDI79313.1 - 0.00092 18.9 0.4 0.0014 18.4 0.3 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 CDI79313.1 - 0.0044 16.6 0.3 0.0062 16.1 0.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ribosomal_60s PF00428.14 CDI79313.1 - 0.0068 16.7 1.0 0.0068 16.7 0.7 3.2 1 1 2 3 3 1 1 60s Acidic ribosomal protein zf-RING_5 PF14634.1 CDI79313.1 - 0.012 15.3 1.2 0.017 14.8 0.8 1.2 1 0 0 1 1 1 0 zinc-RING finger domain FANCL_C PF11793.3 CDI79313.1 - 0.016 15.1 4.7 0.15 12.0 3.3 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Sgf11 PF08209.6 CDI79313.1 - 0.02 14.1 0.1 0.034 13.4 0.1 1.3 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) DUF116 PF01976.12 CDI79313.1 - 0.1 12.1 0.1 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF116 Med3 PF11593.3 CDI79313.1 - 8 5.5 22.0 9.1 5.4 15.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF1647 PF07801.6 CDI79316.1 - 0.18 11.3 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) Tmemb_9 PF05434.6 CDI79316.1 - 0.47 10.1 0.0 0.47 10.1 0.0 2.6 3 0 0 3 3 3 0 TMEM9 LMBR1 PF04791.11 CDI79316.1 - 0.52 8.8 3.7 0.9 8.0 2.6 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein Mnd1 PF03962.10 CDI79316.1 - 1.3 8.6 15.8 2.4 7.7 11.0 1.4 1 0 0 1 1 1 0 Mnd1 family Folliculin PF11704.3 CDI79316.1 - 4 6.9 6.8 11 5.6 4.7 1.7 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport EF-hand_8 PF13833.1 CDI79317.1 - 1.1e-05 24.9 0.8 2.5e-05 23.7 0.5 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 CDI79317.1 - 0.00093 18.4 0.1 0.0024 17.1 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 CDI79317.1 - 0.0016 17.5 0.5 0.0047 16.1 0.3 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 CDI79317.1 - 0.017 15.2 0.1 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 CDI79317.1 - 0.02 14.7 0.4 0.16 11.9 0.1 2.6 3 0 0 3 3 3 0 EF-hand domain TPR_7 PF13176.1 CDI79318.1 - 0.41 10.5 2.2 1.2 9.0 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat HicB PF05534.7 CDI79318.1 - 7 6.3 6.8 0.27 10.8 0.2 2.0 2 0 0 2 2 2 0 HicB family DUF1510 PF07423.6 CDI79319.1 - 0.28 10.5 22.1 0.33 10.2 15.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAP_alpha PF03896.11 CDI79319.1 - 0.61 9.0 7.4 0.67 8.9 5.1 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_pol_3_Rpc31 PF11705.3 CDI79319.1 - 1.2 9.0 17.9 1.4 8.7 12.4 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 UPF0565 PF10561.4 CDI79319.1 - 1.9 7.2 17.8 2.2 7.1 12.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Rtf2 PF04641.7 CDI79319.1 - 2.2 7.4 20.5 2.3 7.3 14.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2052 PF09747.4 CDI79319.1 - 2.6 7.9 26.0 3.1 7.6 18.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DDHD PF02862.12 CDI79319.1 - 2.9 7.6 17.8 3.3 7.4 12.4 1.1 1 0 0 1 1 1 0 DDHD domain DUF4045 PF13254.1 CDI79319.1 - 3.3 6.9 17.9 3.5 6.7 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3449 PF11931.3 CDI79319.1 - 4 6.9 21.7 4.7 6.6 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) SAPS PF04499.10 CDI79319.1 - 4.3 5.8 19.9 4.7 5.7 13.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FLO_LFY PF01698.11 CDI79319.1 - 4.4 6.0 20.0 4.9 5.8 13.9 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Tim54 PF11711.3 CDI79319.1 - 4.5 5.7 14.6 5.2 5.5 10.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sec62 PF03839.11 CDI79319.1 - 5.1 6.4 16.7 5.4 6.3 11.6 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 FAM91_C PF14648.1 CDI79319.1 - 5.6 5.6 13.1 6.2 5.5 9.1 1.0 1 0 0 1 1 1 0 FAM91 C-terminus DUF913 PF06025.7 CDI79319.1 - 5.8 5.5 11.7 6.1 5.4 8.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FNIP_N PF14636.1 CDI79319.1 - 6 7.3 20.6 7.3 7.0 14.3 1.1 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus CDC45 PF02724.9 CDI79319.1 - 7 4.5 19.1 8.2 4.3 13.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3260 PF11658.3 CDI79319.1 - 7.1 4.6 20.0 7.8 4.5 13.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) CKAP2_C PF15297.1 CDI79319.1 - 7.7 5.2 24.9 8.5 5.0 17.3 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus BORG_CEP PF14957.1 CDI79319.1 - 7.8 7.4 15.4 9.3 7.1 10.7 1.1 1 0 0 1 1 1 0 Cdc42 effector Baculo_PP31 PF05311.6 CDI79319.1 - 7.9 5.6 19.8 11 5.2 13.7 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2828 PF11443.3 CDI79319.1 - 8.2 4.4 17.0 9.1 4.3 11.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NARP1 PF12569.3 CDI79319.1 - 8.8 4.9 22.4 10 4.7 15.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM60A PF15396.1 CDI79319.1 - 9.1 5.9 18.6 10 5.8 12.9 1.0 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.4 CDI79320.1 - 0.037 12.2 7.2 0.037 12.2 5.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI79320.1 - 0.32 9.1 18.3 0.33 9.0 12.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4106 PF13388.1 CDI79320.1 - 0.85 8.5 10.8 1.1 8.0 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) LcrG PF07216.7 CDI79320.1 - 1.9 8.5 5.8 13 5.8 3.9 2.1 2 0 0 2 2 2 0 LcrG protein DEAD PF00270.24 CDI79321.1 - 1.1e-16 60.8 0.6 1.1e-16 60.8 0.4 3.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79321.1 - 1.2e-08 34.6 0.0 1.2e-08 34.6 0.0 3.5 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Sporozoite_P67 PF05642.6 CDI79321.1 - 0.00046 18.2 0.1 0.00046 18.2 0.1 6.5 3 3 1 4 4 4 1 Sporozoite P67 surface antigen Helicase_C PF00271.26 CDI79322.1 - 3.7e-18 65.1 0.0 3.7e-18 65.1 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF3439 PF11921.3 CDI79322.1 - 0.0066 16.1 4.5 0.018 14.7 0.4 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) zf-DHHC PF01529.15 CDI79322.1 - 1.3 8.3 2.9 4.3 6.7 0.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase RRM_5 PF13893.1 CDI79323.1 - 2.4e-26 91.3 0.1 4.8e-11 42.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79323.1 - 5.4e-25 87.1 0.1 5.3e-09 35.9 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI79323.1 - 3.8e-22 77.6 0.0 5.6e-09 35.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM117 PF15388.1 CDI79323.1 - 0.002 17.4 1.9 0.0029 16.9 1.3 1.2 1 0 0 1 1 1 1 Protein Family FAM117 Ribosomal_60s PF00428.14 CDI79323.1 - 0.031 14.6 3.9 0.031 14.6 2.7 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF844 PF05815.6 CDI79323.1 - 0.15 10.8 4.7 0.34 9.7 3.2 1.5 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) Spt20 PF12090.3 CDI79323.1 - 0.78 9.0 5.9 0.29 10.4 1.7 1.9 2 0 0 2 2 2 0 Spt20 family Tox-WTIP PF15654.1 CDI79323.1 - 2.4 7.8 6.2 2.3 7.8 0.2 2.4 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif Skp1 PF01466.14 CDI79325.1 - 7.7e-28 96.3 0.0 1.4e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 CDI79325.1 - 3.1e-19 68.7 0.3 6.5e-19 67.7 0.2 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain HdeA PF06411.6 CDI79325.1 - 0.22 11.5 1.1 1.6 8.7 0.0 2.5 2 1 0 2 2 2 0 HdeA/HdeB family RNA_pol_Rpc34 PF05158.7 CDI79327.1 - 6.1e-34 117.6 0.1 2.8e-21 76.0 0.0 2.5 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit UBA_3 PF09288.5 CDI79327.1 - 0.05 13.1 0.1 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Opiods_neuropep PF01160.13 CDI79327.1 - 0.1 12.3 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide m04gp34like PF12216.3 CDI79328.1 - 0.016 14.6 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Immune evasion protein DUF3357 PF11837.3 CDI79328.1 - 0.031 14.1 1.6 0.043 13.6 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) CD99L2 PF12301.3 CDI79328.1 - 0.065 12.9 0.2 0.086 12.5 0.1 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 DUF1628 PF07790.6 CDI79328.1 - 0.082 13.6 1.1 1.1 10.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1628) DUF1510 PF07423.6 CDI79328.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pro_isomerase PF00160.16 CDI79332.1 - 3.9e-35 121.3 0.1 4.5e-35 121.1 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Abi PF02517.11 CDI79333.1 - 0.008 16.2 1.2 0.013 15.5 0.8 1.3 1 0 0 1 1 1 1 CAAX protease self-immunity Bromodomain PF00439.20 CDI79334.1 - 1.8e-13 50.1 0.0 3.3e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Abhydrolase_5 PF12695.2 CDI79338.1 - 6.8e-27 93.9 0.0 1.2e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI79338.1 - 8.3e-20 71.6 0.0 1.7e-18 67.3 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI79338.1 - 6.5e-13 48.7 0.0 8e-09 35.3 0.0 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CDI79338.1 - 1.1e-09 37.8 0.0 2.1e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 CDI79338.1 - 3.8e-08 33.0 0.0 0.0021 17.5 0.0 2.6 3 0 0 3 3 3 2 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.7 CDI79338.1 - 4.5e-07 28.6 0.8 0.002 16.7 0.1 2.2 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) DLH PF01738.13 CDI79338.1 - 5.9e-07 29.0 0.0 1e-05 24.9 0.0 2.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.3 CDI79338.1 - 3.8e-06 26.6 0.1 1e-05 25.2 0.0 1.7 2 0 0 2 2 1 1 Putative lysophospholipase DUF2305 PF10230.4 CDI79338.1 - 0.00026 20.4 0.0 0.44 9.9 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2305) FSH1 PF03959.8 CDI79338.1 - 0.0011 18.4 0.0 0.003 17.0 0.0 1.8 1 0 0 1 1 1 1 Serine hydrolase (FSH1) PGAP1 PF07819.8 CDI79338.1 - 0.0013 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_3 PF07859.8 CDI79338.1 - 0.0014 18.2 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.6 CDI79338.1 - 0.0032 17.2 0.0 0.022 14.4 0.0 2.1 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.20 CDI79338.1 - 0.0045 16.6 0.0 0.0091 15.6 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) DUF1057 PF06342.7 CDI79338.1 - 0.011 14.5 0.0 0.17 10.6 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_2 PF02230.11 CDI79338.1 - 0.022 14.2 0.0 0.09 12.2 0.0 2.0 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase Thioesterase PF00975.15 CDI79338.1 - 0.074 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Clat_adaptor_s PF01217.15 CDI79339.1 - 0.04 13.6 0.1 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Hamartin PF04388.7 CDI79341.1 - 0.064 11.9 0.2 0.071 11.7 0.1 1.1 1 0 0 1 1 1 0 Hamartin protein Spc97_Spc98 PF04130.8 CDI79343.1 - 2.6e-14 52.4 3.1 2.6e-14 52.4 2.2 2.2 2 1 1 3 3 3 1 Spc97 / Spc98 family ThylakoidFormat PF11264.3 CDI79345.1 - 0.034 13.7 3.5 0.054 13.1 2.4 1.3 1 0 0 1 1 1 0 Thylakoid formation protein Herpes_US12 PF05363.7 CDI79345.1 - 0.078 13.4 0.3 0.16 12.4 0.2 1.6 1 0 0 1 1 1 0 Herpesvirus US12 family AbbA_antirepres PF14156.1 CDI79345.1 - 0.1 12.2 1.7 0.21 11.2 1.2 1.4 1 0 0 1 1 1 0 Antirepressor AbbA Spc97_Spc98 PF04130.8 CDI79347.1 - 1.6e-17 63.0 0.0 1.9e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Spc97 / Spc98 family CASP_C PF08172.7 CDI79347.1 - 0.076 12.0 0.1 0.089 11.8 0.1 1.2 1 0 0 1 1 1 0 CASP C terminal DUF3138 PF11336.3 CDI79347.1 - 0.73 7.9 6.8 0.77 7.8 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF3123 PF11321.3 CDI79347.1 - 6 7.1 8.4 10 6.4 5.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3123) DUF2574 PF10836.3 CDI79349.1 - 0.19 11.4 2.5 0.38 10.4 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2574) Pro_isomerase PF00160.16 CDI79350.1 - 3.2e-45 154.0 0.1 3.6e-45 153.9 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PAT1 PF09770.4 CDI79352.1 - 0.0056 14.9 27.0 0.0065 14.7 18.7 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 RabGAP-TBC PF00566.13 CDI79352.1 - 0.16 11.3 11.7 0.62 9.4 0.0 4.0 4 0 0 4 4 4 0 Rab-GTPase-TBC domain AAA_23 PF13476.1 CDI79352.1 - 0.55 10.5 10.1 1.1 9.5 5.5 2.0 2 0 0 2 2 2 0 AAA domain CDK5_activator PF03261.10 CDI79352.1 - 2.7 7.2 26.8 0.12 11.6 5.0 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein DUF508 PF04370.7 CDI79352.1 - 4.9 6.7 21.4 0.58 9.7 1.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF508) KOW PF00467.24 CDI79353.1 - 2.6e-08 33.2 3.3 2.6e-08 33.2 2.3 1.8 2 0 0 2 2 2 1 KOW motif DUF2981 PF11200.3 CDI79354.1 - 0.0002 20.5 0.4 0.0002 20.5 0.3 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2981) PrgI PF12666.2 CDI79354.1 - 0.27 11.4 9.1 0.39 10.8 6.3 1.3 1 0 0 1 1 1 0 PrgI family protein LMF1 PF06762.9 CDI79354.1 - 0.38 9.4 2.3 0.42 9.3 1.6 1.1 1 0 0 1 1 1 0 Lipase maturation factor Nucleoporin2 PF04096.9 CDI79357.1 - 4.1e-34 117.4 0.1 1.6e-33 115.5 0.0 2.2 2 0 0 2 2 2 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 CDI79357.1 - 1.9e-32 111.8 416.8 9.7e-09 35.4 28.8 13.1 7 3 6 13 13 13 8 Nucleoporin FG repeat region Ribosomal_60s PF00428.14 CDI79360.1 - 0.014 15.7 5.8 0.023 15.0 4.0 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein MSP1_C PF07462.6 CDI79360.1 - 0.49 8.7 4.0 0.56 8.5 2.7 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF2057 PF09829.4 CDI79360.1 - 1.1 8.9 4.1 1.4 8.5 2.8 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) WD40 PF00400.27 CDI79361.1 - 7.5e-06 25.6 3.5 0.25 11.2 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Tub_2 PF04525.7 CDI79361.1 - 0.028 13.8 0.1 0.061 12.7 0.1 1.5 1 0 0 1 1 1 0 Tubby C 2 HnRNP_M PF11532.3 CDI79362.1 - 0.21 11.7 3.2 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein M T2SF PF00482.18 CDI79362.1 - 0.99 9.3 3.8 1.5 8.7 2.6 1.3 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F SPT6_acidic PF14632.1 CDI79362.1 - 2.4 8.4 6.0 3.2 7.9 4.0 1.4 1 1 0 1 1 1 0 Acidic N-terminal SPT6 APG6 PF04111.7 CDI79362.1 - 5.1 6.0 12.1 5.5 5.9 8.4 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.1 CDI79362.1 - 5.3 7.3 10.0 6.8 6.9 6.9 1.2 1 0 0 1 1 1 0 AAA domain Mnd1 PF03962.10 CDI79362.1 - 7.4 6.1 12.5 8.8 5.9 8.7 1.1 1 0 0 1 1 1 0 Mnd1 family SprA-related PF12118.3 CDI79362.1 - 8.4 5.6 15.2 10 5.3 10.6 1.1 1 0 0 1 1 1 0 SprA-related family RNA_pol_Rpb2_1 PF04563.10 CDI79363.1 - 4.5e-60 202.0 0.0 6.3e-60 201.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CDI79363.1 - 3.9e-48 163.3 0.0 6.9e-48 162.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_6 PF00562.23 CDI79363.1 - 2e-40 138.7 0.0 3.1e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.11 CDI79363.1 - 3.8e-25 87.4 0.0 7.6e-25 86.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.8 CDI79363.1 - 7.5e-20 70.5 0.1 1.5e-19 69.5 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.12 CDI79363.1 - 5.9e-17 61.3 1.8 1.1e-16 60.4 1.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Peptidase_M16_C PF05193.16 CDI79366.1 - 0.0011 18.6 9.2 0.042 13.5 0.0 3.5 3 1 1 4 4 4 2 Peptidase M16 inactive domain Ycf1 PF05758.7 CDI79366.1 - 0.15 9.7 9.9 0.019 12.7 2.3 2.1 2 0 0 2 2 2 0 Ycf1 Neur_chan_memb PF02932.11 CDI79366.1 - 0.5 10.2 5.8 1.1 9.1 0.3 2.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Baculo_PP31 PF05311.6 CDI79366.1 - 1.9 7.6 11.7 0.17 11.1 2.3 2.5 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Ank PF00023.25 CDI79367.1 - 7.2e-20 69.7 0.3 7.9e-08 31.7 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 CDI79367.1 - 1.3e-17 63.8 5.0 7.2e-10 39.0 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI79367.1 - 4.9e-17 61.9 0.3 4.1e-11 43.0 0.1 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDI79367.1 - 7.6e-17 60.9 0.2 5.3e-08 32.8 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI79367.1 - 5.3e-13 47.8 0.1 0.0011 19.0 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Pol_alpha_B_N PF08418.5 CDI79367.1 - 0.56 9.6 3.6 0.79 9.2 2.5 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Med8 PF10232.4 CDI79367.1 - 1 8.8 4.8 1.4 8.3 3.3 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Chorion_2 PF03964.10 CDI79370.1 - 0.028 14.9 1.2 0.028 14.9 0.8 6.2 4 1 2 6 6 6 0 Chorion family 2 AFT PF08731.6 CDI79370.1 - 0.13 12.4 4.9 8.5 6.6 0.9 2.5 3 0 0 3 3 3 0 Transcription factor AFT DUF3154 PF11351.3 CDI79370.1 - 1.9 8.2 9.0 12 5.7 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3154) IncA PF04156.9 CDI79370.1 - 8.6 5.9 19.1 16 4.9 13.3 1.4 1 0 0 1 1 1 0 IncA protein PRP1_N PF06424.7 CDI79371.1 - 0.0031 17.8 0.5 0.0031 17.8 0.3 5.1 4 1 0 4 4 4 2 PRP1 splicing factor, N-terminal Activator_LAG-3 PF11498.3 CDI79371.1 - 0.0039 16.0 10.5 0.0039 16.0 7.2 5.2 4 1 0 4 4 4 1 Transcriptional activator LAG-3 DUF572 PF04502.8 CDI79371.1 - 0.17 11.0 0.0 0.17 11.0 0.0 4.9 4 1 0 5 5 5 0 Family of unknown function (DUF572) MFS_2 PF13347.1 CDI79372.1 - 2.7e-07 29.3 3.9 4.8e-07 28.5 2.7 1.4 1 1 0 1 1 1 1 MFS/sugar transport protein DUF2681 PF10883.3 CDI79372.1 - 0.00031 20.8 0.2 0.0011 19.1 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) IncA PF04156.9 CDI79372.1 - 0.0013 18.4 1.4 0.0013 18.4 0.9 2.3 2 0 0 2 2 2 1 IncA protein SieB PF14163.1 CDI79372.1 - 0.15 11.6 1.8 0.55 9.7 0.5 2.2 3 0 0 3 3 3 0 Superinfection exclusion protein B Rifin_STEVOR PF02009.11 CDI79372.1 - 7 6.1 7.0 1 8.9 1.8 1.8 2 0 0 2 2 2 0 Rifin/stevor family Glyco_hydro_67N PF03648.9 CDI79373.1 - 0.047 13.7 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus DUF4110 PF13422.1 CDI79373.1 - 0.051 13.3 0.4 0.084 12.7 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) R3H-assoc PF13902.1 CDI79373.1 - 0.09 12.7 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 R3H-associated N-terminal domain NAPRTase PF04095.11 CDI79374.1 - 2.6e-23 82.6 0.0 2.2e-15 56.6 0.0 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family CPSF_A PF03178.10 CDI79376.1 - 7.8e-13 48.1 0.0 2.6e-10 39.9 0.0 2.2 2 0 0 2 2 2 2 CPSF A subunit region DUF3373 PF11853.3 CDI79376.1 - 0.37 9.2 4.8 1.1 7.7 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) eIF-6 PF01912.13 CDI79378.1 - 5.1e-77 257.4 0.1 7e-77 257.0 0.1 1.2 1 0 0 1 1 1 1 eIF-6 family MCM PF00493.18 CDI79379.1 - 1.3e-27 96.4 13.9 9.8e-15 54.1 0.0 3.6 3 1 1 4 4 4 3 MCM2/3/5 family G-alpha PF00503.15 CDI79379.1 - 0.13 10.9 13.1 0.0098 14.6 4.0 2.4 3 0 0 3 3 3 0 G-protein alpha subunit Abhydrolase_1 PF00561.15 CDI79382.1 - 0.0013 18.3 0.2 0.0013 18.3 0.1 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold SR-25 PF10500.4 CDI79382.1 - 0.0078 15.7 4.1 0.0078 15.7 2.8 6.3 6 2 2 8 8 8 1 Nuclear RNA-splicing-associated protein zf-RanBP PF00641.13 CDI79383.1 - 0.017 14.2 31.3 0.33 10.1 9.1 2.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Pkinase PF00069.20 CDI79385.1 - 6.7e-08 31.9 0.0 1.1e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI79385.1 - 4.3e-06 25.8 0.0 6.2e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI79385.1 - 6.8e-06 25.3 0.0 1e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBP1_TM PF14812.1 CDI79385.1 - 1.5 9.1 5.1 3.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AP2 PF00847.15 CDI79386.1 - 0.00015 21.8 3.3 0.016 15.3 0.5 2.3 2 0 0 2 2 2 2 AP2 domain tRNA-synt_2b PF00587.20 CDI79387.1 - 7.5e-20 71.2 0.1 1.2e-19 70.5 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDI79387.1 - 3.3e-18 65.4 0.0 1.5e-17 63.3 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain ProRS-C_1 PF09180.6 CDI79387.1 - 1.6e-15 56.7 0.1 5.5e-15 55.0 0.1 2.0 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA_edit PF04073.10 CDI79387.1 - 2.3e-13 50.0 0.1 7.4e-09 35.5 0.0 2.4 1 1 1 2 2 2 2 Aminoacyl-tRNA editing domain Cas_Cas1 PF01867.11 CDI79387.1 - 0.0053 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 CRISPR associated protein Cas1 DUF726 PF05277.7 CDI79389.1 - 7.2e-97 324.3 2.3 6.9e-48 163.2 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF726) LCAT PF02450.10 CDI79389.1 - 0.18 10.7 0.9 2 7.2 0.0 2.1 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Bromodomain PF00439.20 CDI79390.1 - 2.1e-30 104.4 0.0 7.1e-16 57.9 0.0 2.5 2 0 0 2 2 2 2 Bromodomain V_ATPase_I PF01496.14 CDI79390.1 - 0.76 7.5 3.1 1.1 7.0 2.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rer1 PF03248.8 CDI79391.1 - 3.8e-61 205.7 2.6 4.7e-61 205.4 1.8 1.1 1 0 0 1 1 1 1 Rer1 family IPPT PF01715.12 CDI79400.1 - 3.3e-46 157.3 2.3 1.3e-24 86.6 0.0 3.4 2 2 1 3 3 3 3 IPP transferase AAA_17 PF13207.1 CDI79400.1 - 0.0021 18.8 0.5 0.018 15.8 0.3 2.3 1 1 0 1 1 1 1 AAA domain HTH_17 PF12728.2 CDI79400.1 - 0.0075 16.4 0.0 0.031 14.5 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain Arch_ATPase PF01637.13 CDI79400.1 - 0.018 14.7 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase IPT PF01745.11 CDI79400.1 - 0.021 14.0 0.0 0.037 13.1 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA_33 PF13671.1 CDI79400.1 - 0.038 13.8 0.0 0.1 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CDI79400.1 - 0.042 13.9 0.0 0.24 11.5 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.1 CDI79400.1 - 0.048 13.6 0.1 0.092 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain MobB PF03205.9 CDI79400.1 - 0.075 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 CDI79400.1 - 0.098 13.1 0.1 19 5.8 0.0 3.3 3 1 0 3 3 3 0 Miro-like protein TPK_catalytic PF04263.11 CDI79402.1 - 9.5e-21 73.6 0.0 3.5e-20 71.8 0.0 1.8 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 CDI79402.1 - 4.2e-12 45.5 0.0 8e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain RhodobacterPufX PF11511.3 CDI79403.1 - 0.062 12.7 0.3 0.11 11.9 0.2 1.3 1 0 0 1 1 1 0 Intrinsic membrane protein PufX DUF1180 PF06679.7 CDI79403.1 - 0.09 12.6 0.3 0.12 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) AP2 PF00847.15 CDI79404.1 - 5.6e-08 32.8 0.2 5.6e-08 32.8 0.1 3.2 3 0 0 3 3 3 1 AP2 domain DUF3899 PF13038.1 CDI79405.1 - 1.8 8.7 2.0 7.2 6.8 0.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) HCO3_cotransp PF00955.16 CDI79405.1 - 5.9 5.4 2.2 13 4.2 1.6 1.5 1 0 0 1 1 1 0 HCO3- transporter family tRNA-synt_1e PF01406.14 CDI79406.1 - 5.8e-102 340.8 0.7 3.4e-67 226.7 0.1 2.8 2 2 1 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 CDI79406.1 - 2.4e-12 46.2 0.6 2e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 CDI79406.1 - 0.001 17.1 0.0 0.0088 14.0 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.13 CDI79406.1 - 0.0025 16.5 0.0 0.068 11.8 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (K) DUF3558 PF12079.3 CDI79406.1 - 0.026 14.1 1.5 0.2 11.2 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3558) DDHD PF02862.12 CDI79406.1 - 0.77 9.5 13.8 0.5 10.1 3.7 2.3 2 0 0 2 2 2 0 DDHD domain HAD PF12710.2 CDI79409.1 - 3.1e-13 50.3 0.0 1e-12 48.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDI79409.1 - 2.2e-09 38.0 7.8 2.8e-06 27.9 1.4 4.9 4 1 0 4 4 4 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDI79409.1 - 6.5e-06 26.0 0.0 8.9e-05 22.3 0.0 2.9 3 1 0 3 3 3 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 CDI79409.1 - 0.0007 18.7 1.0 0.0007 18.7 0.7 3.3 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.7 CDI79409.1 - 0.0034 16.9 0.0 0.0034 16.9 0.0 2.9 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF3123 PF11321.3 CDI79409.1 - 1.2 9.3 8.8 4.2 7.6 0.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3123) Med15 PF09606.5 CDI79411.1 - 0.00062 18.1 10.2 0.00062 18.1 7.0 4.1 3 2 0 3 3 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI79411.1 - 0.0013 17.0 33.0 0.0013 17.0 22.9 3.4 3 0 0 3 3 3 1 Topoisomerase II-associated protein PAT1 Hom_end_hint PF05203.11 CDI79411.1 - 0.0051 16.5 2.1 0.0051 16.5 1.5 3.1 3 0 0 3 3 3 1 Hom_end-associated Hint Tim54 PF11711.3 CDI79411.1 - 0.063 11.8 11.9 0.4 9.2 6.6 2.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SOBP PF15279.1 CDI79411.1 - 0.28 11.5 30.2 0.34 11.2 10.0 3.4 3 0 0 3 3 3 0 Sine oculis-binding protein Spore_coat_CotO PF14153.1 CDI79411.1 - 0.44 9.9 44.7 0.03 13.7 16.8 3.3 3 0 0 3 3 3 0 Spore coat protein CotO Herpes_UL87 PF03043.9 CDI79411.1 - 0.6 8.4 9.8 20 3.4 6.7 2.6 2 1 0 2 2 2 0 Herpesvirus UL87 family SAGA-Tad1 PF12767.2 CDI79411.1 - 3.4 7.2 40.1 1.4 8.5 14.7 3.5 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit DDHD PF02862.12 CDI79411.1 - 3.7 7.2 29.0 12 5.5 14.3 3.2 3 0 0 3 3 3 0 DDHD domain Neur_chan_memb PF02932.11 CDI79411.1 - 4.1 7.2 24.2 2.6 7.8 9.4 3.2 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region SET PF00856.23 CDI79411.1 - 4.9 7.4 6.8 20 5.4 1.6 3.4 3 1 1 4 4 4 0 SET domain Ycf1 PF05758.7 CDI79411.1 - 7.1 4.1 27.5 0.29 8.8 12.1 2.6 3 0 0 3 3 3 0 Ycf1 KH_1 PF00013.24 CDI79412.1 - 1.1e-08 34.6 0.1 1.8e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 KH domain zf-CCHC_4 PF14392.1 CDI79412.1 - 6.5e-06 25.7 2.1 0.014 15.0 0.0 2.5 2 0 0 2 2 2 2 Zinc knuckle KH_3 PF13014.1 CDI79412.1 - 0.00012 21.5 0.3 0.00027 20.4 0.2 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.1 CDI79412.1 - 0.00082 19.0 1.7 0.46 10.2 0.3 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 CDI79412.1 - 0.0013 18.5 4.1 0.044 13.7 0.3 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.1 CDI79412.1 - 0.028 13.9 4.8 1.1 8.8 0.7 3.1 1 1 1 2 2 2 0 Zinc knuckle DUF4206 PF13901.1 CDI79412.1 - 0.042 13.3 0.9 0.063 12.8 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) zf-CCHC_6 PF15288.1 CDI79412.1 - 0.05 13.2 4.2 3.5 7.3 0.1 3.0 2 0 0 2 2 2 0 Zinc knuckle zf-LSD1 PF06943.7 CDI79412.1 - 1.2 8.8 5.2 6.6 6.4 0.1 2.6 2 0 0 2 2 2 0 LSD1 zinc finger DUF1077 PF06417.7 CDI79414.1 - 3e-08 33.0 0.0 3e-08 33.0 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1077) Pkinase PF00069.20 CDI79415.1 - 3.4e-40 137.8 0.5 2.3e-39 135.1 0.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79415.1 - 2.5e-16 59.5 0.1 1.3e-15 57.2 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase TFIIA PF03153.8 CDI79415.1 - 0.011 15.6 15.2 0.013 15.3 10.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF908 PF06012.7 CDI79415.1 - 0.011 15.0 0.7 0.015 14.6 0.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) PAT1 PF09770.4 CDI79415.1 - 0.018 13.3 22.5 0.021 13.0 15.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SET PF00856.23 CDI79415.1 - 0.14 12.4 0.3 0.31 11.3 0.2 1.6 1 1 0 1 1 1 0 SET domain YrbL-PhoP_reg PF10707.4 CDI79415.1 - 0.21 10.8 7.0 0.63 9.3 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL MMR1 PF08505.5 CDI79415.1 - 0.36 10.8 9.9 0.52 10.3 6.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Baculo_PP31 PF05311.6 CDI79415.1 - 0.42 9.8 5.4 0.58 9.3 3.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Suf PF05843.9 CDI79415.1 - 0.46 10.1 7.6 0.38 10.4 4.2 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF2813 PF11398.3 CDI79415.1 - 0.49 9.4 8.6 0.71 8.8 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) APH PF01636.18 CDI79415.1 - 0.69 9.5 15.3 0.4 10.3 0.1 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family OATP PF03137.15 CDI79415.1 - 0.95 7.4 2.6 1.2 7.0 1.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Spore_coat_CotO PF14153.1 CDI79415.1 - 1.5 8.2 16.0 2.2 7.7 11.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Serinc PF03348.10 CDI79415.1 - 2.3 6.8 3.9 3.1 6.4 2.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ras PF00071.17 CDI79417.1 - 6e-39 133.0 0.0 6.7e-39 132.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI79417.1 - 3.4e-14 53.3 0.0 4.2e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDI79417.1 - 8.9e-11 41.3 0.0 9.3e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDI79417.1 - 0.00019 20.6 0.0 0.00023 20.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 CDI79417.1 - 0.0063 16.4 0.0 0.011 15.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 CDI79417.1 - 0.0079 16.3 0.1 0.065 13.4 0.1 2.0 1 1 0 1 1 1 1 RNA helicase AAA_22 PF13401.1 CDI79417.1 - 0.013 15.6 0.1 0.059 13.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 CDI79417.1 - 0.034 13.8 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.17 CDI79417.1 - 0.037 12.8 0.0 0.074 11.8 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain DUF258 PF03193.11 CDI79417.1 - 0.05 12.7 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 CDI79417.1 - 0.051 13.5 0.0 0.065 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.13 CDI79417.1 - 0.072 12.0 0.0 0.092 11.7 0.0 1.1 1 0 0 1 1 1 0 Septin NACHT PF05729.7 CDI79417.1 - 0.082 12.5 0.2 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 NACHT domain G-alpha PF00503.15 CDI79417.1 - 0.083 11.5 0.1 0.22 10.1 0.0 1.7 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.4 CDI79417.1 - 0.098 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.9 CDI79417.1 - 0.1 12.3 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 CDI79417.1 - 0.12 11.9 0.1 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain TPR_12 PF13424.1 CDI79418.1 - 1.6e-06 27.9 14.8 0.17 11.8 0.1 7.4 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 CDI79418.1 - 0.00011 21.6 2.6 7.8 6.5 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 CDI79418.1 - 0.00096 18.9 11.4 1.5 8.6 0.2 5.9 5 0 0 5 5 5 2 Mad3/BUB1 homology region 1 PPR PF01535.15 CDI79418.1 - 0.16 12.0 0.4 11 6.2 0.0 3.7 3 0 0 3 3 3 0 PPR repeat RPN7 PF10602.4 CDI79418.1 - 0.25 10.7 16.9 0.16 11.3 0.1 4.5 6 1 0 6 6 6 0 26S proteasome subunit RPN7 TPR_1 PF00515.23 CDI79418.1 - 0.79 9.4 5.4 3 7.6 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDI79418.1 - 9.3 6.4 31.1 2.2 8.4 0.1 8.8 10 0 0 10 10 10 0 Tetratricopeptide repeat EF-hand_6 PF13405.1 CDI79419.1 - 3.6e-05 23.2 0.1 0.00011 21.7 0.1 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 CDI79419.1 - 9.6e-05 21.4 1.0 0.0002 20.4 0.4 1.7 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 CDI79419.1 - 0.0002 20.5 1.0 0.00051 19.2 0.7 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 CDI79419.1 - 0.0077 16.3 0.5 0.013 15.6 0.4 1.7 1 1 0 1 1 1 1 EF-hand domain pair SNase PF00565.12 CDI79420.1 - 9e-12 45.2 0.5 3.6e-08 33.6 0.0 3.6 3 1 1 4 4 4 2 Staphylococcal nuclease homologue EF-hand_7 PF13499.1 CDI79422.1 - 5.8e-10 39.1 0.8 0.00022 21.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI79422.1 - 2.2e-09 36.4 5.3 0.00044 19.9 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 CDI79422.1 - 2e-08 32.9 4.1 0.002 17.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 CDI79422.1 - 1.8e-05 24.2 1.6 0.42 10.2 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 CDI79422.1 - 0.00024 20.2 9.0 0.028 13.7 0.0 2.8 3 0 0 3 3 3 2 EF hand Gly-zipper_OmpA PF13436.1 CDI79422.1 - 0.015 14.9 13.2 0.024 14.2 9.2 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain EF-hand_9 PF14658.1 CDI79422.1 - 0.02 14.8 0.0 0.29 11.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain DUF1456 PF07308.8 CDI79422.1 - 0.15 12.1 0.2 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) Shadoo PF14999.1 CDI79422.1 - 1.2 9.0 13.3 1.4 8.7 8.4 1.8 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Bacteriocin_IIc PF10439.4 CDI79422.1 - 5.4 7.2 10.8 11 6.2 7.5 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Macro PF01661.16 CDI79424.1 - 0.0002 21.2 3.5 0.0021 17.9 0.0 3.3 2 1 1 3 3 3 1 Macro domain Spt20 PF12090.3 CDI79424.1 - 0.96 8.7 24.9 1.2 8.4 0.1 5.0 5 0 0 5 5 5 0 Spt20 family Bac_surface_Ag PF01103.18 CDI79426.1 - 1.3e-09 37.9 0.0 1.5e-08 34.5 0.0 2.3 1 1 0 1 1 1 1 Surface antigen AAA PF00004.24 CDI79428.1 - 1.2e-51 174.3 0.0 7.5e-39 132.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI79428.1 - 2.7e-10 40.5 1.2 5.8e-05 23.1 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 CDI79428.1 - 6.2e-10 39.3 1.3 0.0018 18.3 0.2 4.4 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 CDI79428.1 - 8.2e-10 38.5 0.1 0.00073 19.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CDI79428.1 - 1.5e-09 37.4 0.1 0.0016 18.1 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain AAA_17 PF13207.1 CDI79428.1 - 4.7e-09 37.1 0.0 0.0061 17.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 CDI79428.1 - 2.5e-08 33.0 0.0 0.0012 17.6 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_18 PF13238.1 CDI79428.1 - 5.7e-08 33.1 0.0 0.014 15.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 CDI79428.1 - 3.5e-07 29.5 0.1 0.012 14.7 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 CDI79428.1 - 5.4e-07 28.9 0.1 0.026 13.5 0.0 2.8 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CDI79428.1 - 5.8e-07 29.4 0.0 0.026 14.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 CDI79428.1 - 6.5e-07 29.1 0.4 0.022 14.4 0.0 3.7 3 1 0 3 3 3 2 NACHT domain CDC48_2 PF02933.12 CDI79428.1 - 4.4e-06 26.2 0.3 5.2e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 RNA_helicase PF00910.17 CDI79428.1 - 5.6e-06 26.4 0.0 0.059 13.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.9 CDI79428.1 - 6.9e-06 26.0 0.0 0.0014 18.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 CDI79428.1 - 1.7e-05 24.7 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 CDI79428.1 - 1.9e-05 24.1 0.0 0.023 14.1 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.1 CDI79428.1 - 2e-05 24.6 0.0 0.28 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.6 CDI79428.1 - 5.2e-05 22.8 0.0 0.41 10.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 CDI79428.1 - 6.3e-05 22.6 0.1 0.42 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.1 CDI79428.1 - 7e-05 22.5 0.9 0.082 12.4 0.2 2.3 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 CDI79428.1 - 9.6e-05 21.5 0.0 0.36 9.7 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.7 CDI79428.1 - 0.00016 20.8 0.3 0.36 9.8 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 CDI79428.1 - 0.00018 20.9 3.8 0.23 10.8 0.0 3.3 2 2 2 4 4 4 2 AAA domain Sigma54_activat PF00158.21 CDI79428.1 - 0.00021 20.7 0.0 0.66 9.4 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain KTI12 PF08433.5 CDI79428.1 - 0.00025 20.3 0.0 0.25 10.5 0.0 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 KaiC PF06745.8 CDI79428.1 - 0.0003 19.9 0.1 0.032 13.3 0.0 2.3 2 0 0 2 2 2 1 KaiC NB-ARC PF00931.17 CDI79428.1 - 0.00038 19.4 0.4 0.81 8.4 0.0 2.8 2 1 1 3 3 3 2 NB-ARC domain PhoH PF02562.11 CDI79428.1 - 0.0004 19.6 0.0 0.9 8.7 0.0 2.6 2 1 0 2 2 2 2 PhoH-like protein UPF0079 PF02367.12 CDI79428.1 - 0.00044 19.8 0.3 0.26 10.9 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 ResIII PF04851.10 CDI79428.1 - 0.00072 19.4 0.0 0.76 9.5 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ABC_tran PF00005.22 CDI79428.1 - 0.0012 19.0 0.2 0.099 12.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_11 PF13086.1 CDI79428.1 - 0.0024 17.4 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 CDI79428.1 - 0.0026 17.7 0.0 3.2 7.7 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 CDI79428.1 - 0.0031 17.2 0.3 1.3 8.6 0.2 3.5 2 2 1 4 4 4 1 Archaeal ATPase Parvo_NS1 PF01057.12 CDI79428.1 - 0.0087 14.9 0.0 0.19 10.5 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DEAD PF00270.24 CDI79428.1 - 0.015 14.7 1.8 19 4.6 0.1 4.2 3 2 1 4 4 4 0 DEAD/DEAH box helicase NTPase_1 PF03266.10 CDI79428.1 - 0.025 14.3 0.1 8.2 6.1 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_29 PF13555.1 CDI79428.1 - 0.049 13.1 0.5 1.6 8.3 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain CPT PF07931.7 CDI79428.1 - 0.064 12.8 0.1 0.39 10.3 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Vps4_C PF09336.5 CDI79428.1 - 0.11 12.3 0.1 2.7 7.9 0.0 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain APS_kinase PF01583.15 CDI79428.1 - 0.12 12.0 0.1 13 5.4 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase KAP_NTPase PF07693.9 CDI79428.1 - 0.13 11.2 0.1 11 4.8 0.0 2.5 2 1 1 3 3 3 0 KAP family P-loop domain Viral_helicase1 PF01443.13 CDI79428.1 - 0.13 11.7 0.0 1.1 8.7 0.0 2.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase SKI PF01202.17 CDI79428.1 - 0.14 12.0 2.5 8.4 6.2 0.1 2.9 2 1 1 3 3 3 0 Shikimate kinase ATP-synt_ab PF00006.20 CDI79428.1 - 0.17 11.3 0.0 4.1 6.8 0.0 2.8 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF4201 PF13870.1 CDI79430.1 - 7.2e-20 71.1 15.4 7.2e-20 71.1 10.7 4.5 3 1 0 4 4 4 2 Domain of unknown function (DUF4201) Ank_4 PF13637.1 CDI79430.1 - 6.5e-05 23.3 0.8 0.19 12.3 0.0 3.9 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI79430.1 - 0.002 18.4 0.2 0.049 13.9 0.0 3.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CDI79430.1 - 0.026 14.7 2.1 19 5.6 0.0 3.9 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Bestrophin PF01062.16 CDI79430.1 - 0.056 12.3 10.7 0.18 10.6 3.0 2.7 2 1 1 3 3 3 0 Bestrophin, RFP-TM, chloride channel Ank_2 PF12796.2 CDI79431.1 - 2.3e-46 156.0 23.1 2.6e-14 53.3 0.5 5.1 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 CDI79431.1 - 1e-29 100.7 14.2 3.9e-06 26.4 0.0 8.0 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.1 CDI79431.1 - 2e-25 88.2 11.2 5.3e-10 39.2 0.0 6.2 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDI79431.1 - 8.5e-25 86.6 6.1 4e-05 23.9 0.0 7.1 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI79431.1 - 3.5e-20 70.0 5.2 0.01 16.0 0.1 7.2 7 0 0 7 7 7 5 Ankyrin repeat Sushi PF00084.15 CDI79431.1 - 5.9e-06 26.5 0.2 1.1e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Sushi domain (SCR repeat) Sec63 PF02889.11 CDI79432.1 - 1e-37 130.1 0.1 1.6e-37 129.4 0.1 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.26 CDI79432.1 - 4.3e-21 74.3 0.4 1.1e-20 73.0 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain DREPP PF05558.7 CDI79432.1 - 5.4 6.8 14.5 0.99 9.2 7.6 1.6 2 0 0 2 2 2 0 DREPP plasma membrane polypeptide BTB PF00651.26 CDI79433.1 - 0.0016 18.3 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ribosomal_L27 PF01016.14 CDI79434.1 - 2e-12 46.6 0.0 8.5e-07 28.6 0.0 2.4 2 0 0 2 2 2 2 Ribosomal L27 protein 2OG-FeII_Oxy_2 PF13532.1 CDI79438.1 - 0.0014 18.5 0.0 0.017 14.9 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DEC-1_N PF04625.8 CDI79438.1 - 0.023 13.3 8.5 0.029 13.0 5.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF2360 PF10152.4 CDI79438.1 - 4 7.6 6.3 6.6 7.0 4.4 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) RNB PF00773.14 CDI79440.1 - 1.3e-35 123.2 1.6 4.6e-17 62.2 0.0 2.9 1 1 1 2 2 2 2 RNB domain Pex14_N PF04695.8 CDI79440.1 - 1.8 8.5 19.9 1.2 9.2 0.2 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_60s PF00428.14 CDI79440.1 - 6.8 7.1 33.2 1.6 9.2 7.9 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein FimP PF09766.4 CDI79441.1 - 0.0031 16.6 37.6 0.011 14.7 12.8 2.1 2 0 0 2 2 2 2 Fms-interacting protein Activator_LAG-3 PF11498.3 CDI79441.1 - 0.0047 15.7 59.0 0.071 11.8 13.9 2.4 2 0 0 2 2 2 2 Transcriptional activator LAG-3 DUF3801 PF12687.2 CDI79441.1 - 0.028 14.0 22.4 0.37 10.3 4.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) CAF-1_p150 PF11600.3 CDI79441.1 - 0.11 11.8 48.6 0.18 11.1 12.1 3.3 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal zf-DHHC PF01529.15 CDI79441.1 - 0.26 10.6 9.4 2.7 7.3 0.0 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF2052 PF09747.4 CDI79441.1 - 0.46 10.3 24.6 0.29 11.0 8.5 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Cwf_Cwc_15 PF04889.7 CDI79441.1 - 0.48 10.1 24.2 1.4 8.5 9.2 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ycf1 PF05758.7 CDI79441.1 - 2.4 5.7 18.2 0.28 8.8 5.5 2.0 2 0 0 2 2 2 0 Ycf1 Raftlin PF15250.1 CDI79441.1 - 2.5 6.5 28.0 1.1 7.6 7.8 2.2 2 0 0 2 2 2 0 Raftlin FLO_LFY PF01698.11 CDI79441.1 - 2.6 6.7 25.8 0.95 8.2 2.6 2.3 2 0 0 2 2 2 0 Floricaula / Leafy protein U1snRNP70_N PF12220.3 CDI79441.1 - 2.9 8.2 23.9 4.2 7.7 3.1 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Parvo_coat PF00740.13 CDI79441.1 - 4.8 6.0 32.2 4.7 6.0 8.7 2.1 2 0 0 2 2 2 0 Parvovirus coat protein VP2 Spore_coat_CotO PF14153.1 CDI79441.1 - 5.6 6.3 34.3 0.87 9.0 11.5 2.3 2 0 0 2 2 2 0 Spore coat protein CotO Serinc PF03348.10 CDI79441.1 - 6.4 5.3 26.4 3.7 6.1 2.9 2.6 2 0 0 2 2 2 0 Serine incorporator (Serinc) eIF-3_zeta PF05091.7 CDI79441.1 - 6.8 5.1 28.2 1.4 7.4 8.2 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Na_trans_assoc PF06512.8 CDI79444.1 - 0.59 10.0 4.7 0.92 9.4 3.2 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated SAPS PF04499.10 CDI79444.1 - 3.6 6.1 7.7 4.8 5.7 5.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein tRNA_bind PF01588.15 CDI79446.1 - 2.1e-24 85.2 0.0 5e-24 83.9 0.0 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 CDI79446.1 - 1.1e-07 32.2 1.1 2.3e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CDI79446.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CDI79446.1 - 0.002 18.0 2.2 0.0024 17.8 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain CDK2AP PF09806.4 CDI79446.1 - 0.017 15.4 13.5 0.026 14.7 9.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein FAM176 PF14851.1 CDI79446.1 - 0.019 14.6 1.3 0.038 13.6 0.9 1.5 1 0 0 1 1 1 0 FAM176 family TraV PF09676.5 CDI79446.1 - 0.023 15.3 1.5 0.042 14.5 1.0 1.5 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Ndc1_Nup PF09531.5 CDI79446.1 - 0.2 10.0 0.5 0.24 9.7 0.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BAF1_ABF1 PF04684.8 CDI79446.1 - 0.42 9.4 7.5 0.59 8.9 5.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NARP1 PF12569.3 CDI79446.1 - 1.3 7.7 9.3 1.7 7.2 6.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Allexi_40kDa PF05549.6 CDI79447.1 - 6 6.0 10.6 4.1 6.6 5.9 1.8 1 1 0 1 1 1 0 Allexivirus 40kDa protein Abhydrolase_5 PF12695.2 CDI79448.1 - 7.1e-19 68.0 0.0 1.3e-18 67.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI79448.1 - 1e-17 64.7 0.0 1.4e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 CDI79448.1 - 1.7e-08 34.2 0.0 1.9e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.16 CDI79448.1 - 2.8e-08 33.2 0.0 5.4e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 CDI79448.1 - 1.3e-07 31.3 0.0 3.9e-07 29.8 0.0 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.7 CDI79448.1 - 2.1e-07 29.7 0.1 1.5e-05 23.7 0.0 2.6 3 0 0 3 3 3 1 Acetyl xylan esterase (AXE1) DLH PF01738.13 CDI79448.1 - 1.8e-06 27.3 0.0 0.00028 20.2 0.0 2.4 2 1 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.3 CDI79448.1 - 3e-05 23.7 0.0 6.1e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 CDI79448.1 - 0.0016 18.0 0.0 0.0076 15.8 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.20 CDI79448.1 - 0.0027 17.3 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) BAAT_C PF08840.6 CDI79448.1 - 0.0061 16.2 0.1 1.6 8.4 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.11 CDI79448.1 - 0.0073 15.7 0.0 0.85 9.0 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase FSH1 PF03959.8 CDI79448.1 - 0.0077 15.7 0.0 0.13 11.6 0.0 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) LIP PF03583.9 CDI79448.1 - 0.036 13.2 0.1 5.2 6.1 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase DEAD PF00270.24 CDI79449.1 - 1e-15 57.6 0.0 4.1e-15 55.6 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pox_RNA_Pol_19 PF05320.7 CDI79449.1 - 0.0091 15.7 3.6 0.0091 15.7 2.5 4.3 5 0 0 5 5 5 1 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF3446 PF11928.3 CDI79449.1 - 1.4 9.1 25.2 2.4 8.4 1.6 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF3446) K_channel_TID PF07941.6 CDI79449.1 - 4.3 7.6 25.8 0.47 10.7 7.6 3.9 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain XendoU PF09412.5 CDI79450.1 - 0.034 13.1 0.1 0.056 12.4 0.1 1.3 1 0 0 1 1 1 0 Endoribonuclease XendoU SR-25 PF10500.4 CDI79450.1 - 0.26 10.7 17.2 0.029 13.8 3.6 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AAA_11 PF13086.1 CDI79451.1 - 9.6e-57 192.2 4.6 9.6e-57 192.2 3.2 4.1 3 2 0 3 3 3 1 AAA domain AAA_12 PF13087.1 CDI79451.1 - 1.2e-55 188.0 0.1 3.9e-55 186.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDI79451.1 - 2.3e-12 46.4 0.1 2.3e-12 46.4 0.1 5.9 6 1 0 6 6 4 1 Part of AAA domain Viral_helicase1 PF01443.13 CDI79451.1 - 1.3e-05 24.8 9.9 0.64 9.4 0.0 4.8 5 0 0 5 5 5 3 Viral (Superfamily 1) RNA helicase ResIII PF04851.10 CDI79451.1 - 6.7e-05 22.8 0.4 6.7e-05 22.8 0.2 3.8 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CDI79451.1 - 0.00046 20.3 0.1 0.0062 16.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDI79451.1 - 0.0006 19.2 1.6 0.0069 15.8 0.0 3.3 3 0 0 3 3 3 1 AAA domain UvrD_C_2 PF13538.1 CDI79451.1 - 0.0014 18.7 0.8 0.0048 17.0 0.0 2.4 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA PF00004.24 CDI79451.1 - 0.0021 18.2 0.4 0.038 14.1 0.0 3.3 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDI79451.1 - 0.0025 18.6 0.0 0.044 14.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CDI79451.1 - 0.042 14.1 0.1 0.19 12.0 0.0 2.2 2 0 0 2 2 1 0 AAA domain CbiA PF01656.18 CDI79451.1 - 1.3 8.3 6.0 7.9 5.8 4.2 2.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.17 CDI79452.1 - 8e-45 152.7 0.1 1.7e-44 151.6 0.1 1.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain CbiA PF01656.18 CDI79452.1 - 0.00099 18.5 0.0 0.0012 18.2 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Response_reg PF00072.19 CDI79452.1 - 0.08 12.9 0.1 0.16 12.0 0.1 1.7 1 1 0 1 1 1 0 Response regulator receiver domain LRR_4 PF12799.2 CDI79454.1 - 2.1e-05 23.9 2.1 2.1e-05 23.9 1.5 2.1 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI79454.1 - 8.3e-05 22.2 3.3 0.00027 20.6 0.6 2.5 2 0 0 2 2 2 1 Leucine rich repeat Acetyltransf_2 PF00797.12 CDI79455.1 - 0.044 13.3 3.0 0.045 13.3 2.1 1.1 1 0 0 1 1 1 0 N-acetyltransferase NST1 PF13945.1 CDI79455.1 - 0.062 13.3 15.8 0.074 13.1 11.0 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator EspB PF05802.6 CDI79455.1 - 0.11 11.4 18.7 0.15 10.9 13.0 1.1 1 0 0 1 1 1 0 Enterobacterial EspB protein HD-ZIP_N PF04618.7 CDI79455.1 - 0.18 12.3 1.6 0.24 11.9 1.1 1.2 1 0 0 1 1 1 0 HD-ZIP protein N terminus Hist_deacetyl PF00850.14 CDI79455.1 - 0.54 9.4 5.8 0.64 9.2 4.0 1.1 1 0 0 1 1 1 0 Histone deacetylase domain DUF3153 PF11353.3 CDI79455.1 - 0.55 9.6 6.6 0.62 9.4 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3153) DUF4647 PF15504.1 CDI79455.1 - 1.2 7.9 13.5 1.3 7.8 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Hamartin PF04388.7 CDI79455.1 - 1.4 7.5 6.8 1.6 7.3 4.7 1.0 1 0 0 1 1 1 0 Hamartin protein Med15 PF09606.5 CDI79455.1 - 1.6 6.8 25.5 1.9 6.5 17.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Red1 PF07964.6 CDI79455.1 - 3.7 5.5 9.4 3.8 5.5 6.5 1.0 1 0 0 1 1 1 0 Rec10 / Red1 Draxin PF15550.1 CDI79455.1 - 3.8 7.0 12.8 4.6 6.8 8.9 1.1 1 0 0 1 1 1 0 Draxin FimP PF09766.4 CDI79455.1 - 3.9 6.4 13.8 4.7 6.1 9.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein CDK5_activator PF03261.10 CDI79455.1 - 3.9 6.7 12.9 4.6 6.4 9.0 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein PAT1 PF09770.4 CDI79455.1 - 4.2 5.4 21.2 5.2 5.1 14.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 VSG_B PF13206.1 CDI79455.1 - 5.2 6.0 30.5 6.3 5.8 21.2 1.0 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF3807 PF12720.2 CDI79455.1 - 6.2 6.9 18.3 8.7 6.4 12.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Band_3_cyto PF07565.8 CDI79455.1 - 6.6 6.1 10.1 6.7 6.1 6.7 1.3 1 1 0 1 1 1 0 Band 3 cytoplasmic domain DUF966 PF06136.8 CDI79455.1 - 10 5.4 15.5 12 5.2 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SNF2_N PF00176.18 CDI79456.1 - 9.9e-09 34.4 0.0 6.3e-05 21.9 0.0 3.4 2 1 0 2 2 2 2 SNF2 family N-terminal domain Ribosomal_60s PF00428.14 CDI79456.1 - 0.01 16.2 4.7 0.01 16.2 3.3 19.0 13 5 1 14 14 14 0 60s Acidic ribosomal protein Helicase_C PF00271.26 CDI79457.1 - 4.7e-08 32.7 1.0 1.6e-07 31.0 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF2547 PF10818.3 CDI79457.1 - 9.1 6.9 25.0 0.16 12.5 4.9 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2547) GN3L_Grn1 PF08701.6 CDI79460.1 - 0.058 13.3 0.5 0.058 13.3 0.4 2.3 2 0 0 2 2 2 0 GNL3L/Grn1 putative GTPase WBP-1 PF11669.3 CDI79460.1 - 0.53 10.3 5.8 1.5 8.9 0.0 3.2 3 0 0 3 3 3 0 WW domain-binding protein 1 DUF3357 PF11837.3 CDI79460.1 - 6.9 6.5 14.0 1.9 8.3 0.0 4.6 4 1 1 5 5 5 0 Domain of unknown function (DUF3357) PAT1 PF09770.4 CDI79462.1 - 0.0033 15.7 21.8 0.0033 15.7 15.1 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI79462.1 - 0.19 9.8 40.0 0.3 9.2 27.7 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_23 PF13476.1 CDI79462.1 - 3.6 7.8 7.8 5.1 7.3 5.4 1.3 1 0 0 1 1 1 0 AAA domain RrnaAD PF00398.15 CDI79464.1 - 4.1e-19 68.6 0.0 1.3e-18 66.9 0.0 1.8 1 1 1 2 2 2 1 Ribosomal RNA adenine dimethylase PseudoU_synth_2 PF00849.17 CDI79464.1 - 1.5e-17 63.9 1.4 1.5e-17 63.9 1.0 3.5 4 0 0 4 4 4 1 RNA pseudouridylate synthase Methyltransf_18 PF12847.2 CDI79464.1 - 0.0046 17.5 0.4 0.044 14.3 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI79464.1 - 0.011 15.5 0.0 0.011 15.5 0.0 5.1 5 2 0 6 6 6 0 Methyltransferase domain Methyltransf_12 PF08242.7 CDI79464.1 - 7.4 7.1 0.0 7.4 7.1 0.0 4.9 7 1 0 7 7 7 0 Methyltransferase domain Helicase_RecD PF05127.9 CDI79467.1 - 1.1 8.8 4.8 3.3 7.3 1.1 2.2 2 1 0 2 2 2 0 Helicase DUF4512 PF14975.1 CDI79467.1 - 1.9 9.3 7.1 33 5.3 4.9 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) TFIIA PF03153.8 CDI79467.1 - 4.6 7.0 26.2 6.8 6.4 18.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_M1 PF01433.15 CDI79468.1 - 4.9e-29 101.5 0.0 7e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 DUF3336 PF11815.3 CDI79469.1 - 1.3e-09 37.7 0.2 1.3e-09 37.7 0.1 2.3 3 1 0 3 3 3 1 Domain of unknown function (DUF3336) Mitofilin PF09731.4 CDI79469.1 - 0.0025 16.5 0.6 0.0025 16.5 0.4 3.2 2 1 1 3 3 3 1 Mitochondrial inner membrane protein Sporozoite_P67 PF05642.6 CDI79469.1 - 0.009 13.9 9.3 0.013 13.3 6.5 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen Spt20 PF12090.3 CDI79469.1 - 0.24 10.7 12.0 3.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Spt20 family DALR_1 PF05746.10 CDI79471.1 - 9.5e-11 41.7 4.9 1.1e-10 41.4 0.1 3.3 2 1 0 2 2 2 1 DALR anticodon binding domain SR-25 PF10500.4 CDI79471.1 - 0.00029 20.3 18.3 0.00029 20.3 12.7 11.1 7 3 3 10 10 10 2 Nuclear RNA-splicing-associated protein PAP_assoc PF03828.14 CDI79474.1 - 1.2e-05 25.1 0.0 3.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 CDI79474.1 - 0.046 14.0 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase domain STT3 PF02516.9 CDI79475.1 - 0.025 13.5 1.9 0.059 12.3 1.3 1.6 1 0 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit DUF4179 PF13786.1 CDI79475.1 - 0.98 9.6 0.0 0.98 9.6 0.0 4.6 4 1 1 5 5 5 0 Domain of unknown function (DUF4179) Peptidase_C1 PF00112.18 CDI79476.1 - 4.9e-63 212.9 26.5 1.9e-51 175.0 3.2 2.7 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.7 CDI79476.1 - 4.4e-12 46.0 0.2 9.7e-12 44.9 0.1 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) PAT1 PF09770.4 CDI79476.1 - 1.2 7.3 56.4 1.8 6.7 39.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PLRV_ORF5 PF01690.12 CDI79476.1 - 1.6 7.8 14.5 2.6 7.1 10.0 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Ycf1 PF05758.7 CDI79476.1 - 7.6 4.1 20.1 11 3.5 13.9 1.1 1 0 0 1 1 1 0 Ycf1 PT PF04886.7 CDI79479.1 - 2.8e-05 23.3 21.2 0.00037 19.7 5.7 5.1 1 1 3 4 4 4 3 PT repeat FAM91_C PF14648.1 CDI79479.1 - 0.16 10.7 6.5 0.45 9.2 0.0 2.3 2 0 0 2 2 2 0 FAM91 C-terminus MASE1 PF05231.9 CDI79479.1 - 0.99 8.3 7.3 1.9 7.4 5.0 1.4 1 0 0 1 1 1 0 MASE1 UPF0160 PF03690.8 CDI79481.1 - 2e-65 221.3 5.2 2.8e-29 102.5 0.2 4.4 3 2 1 4 4 4 4 Uncharacterised protein family (UPF0160) CENP-F_leu_zip PF10473.4 CDI79481.1 - 0.021 14.6 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SR-25 PF10500.4 CDI79481.1 - 0.093 12.1 3.8 0.3 10.5 0.4 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CGI-121 PF08617.5 CDI79483.1 - 1.8e-15 56.9 1.8 2.6e-14 53.2 0.1 3.0 2 1 0 2 2 2 1 Kinase binding protein CGI-121 Pox_Ag35 PF03286.9 CDI79483.1 - 0.0081 15.7 3.2 0.0081 15.7 2.2 1.7 2 0 0 2 2 2 1 Pox virus Ag35 surface protein Ribosomal_60s PF00428.14 CDI79483.1 - 0.027 14.8 4.7 0.058 13.7 3.2 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Activator_LAG-3 PF11498.3 CDI79483.1 - 0.23 10.1 30.0 0.25 10.0 12.8 2.5 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Band_3_cyto PF07565.8 CDI79483.1 - 0.25 10.8 10.4 0.079 12.4 3.0 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Chorion_S16 PF05836.7 CDI79483.1 - 1.5 8.7 5.3 3.9 7.4 3.7 1.7 1 0 0 1 1 1 0 Chorion protein S16 Suf PF05843.9 CDI79483.1 - 1.7 8.3 12.8 0.37 10.4 4.0 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Bul1_N PF04425.7 CDI79483.1 - 2 6.8 14.8 0.7 8.3 7.7 1.9 2 0 0 2 2 2 0 Bul1 N terminus FCP1_C PF09309.5 CDI79483.1 - 3.1 7.0 18.1 0.5 9.6 8.2 2.5 2 0 0 2 2 2 0 FCP1, C-terminal Dicty_REP PF05086.7 CDI79483.1 - 3.8 5.1 13.8 6.5 4.3 9.5 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIIA PF03153.8 CDI79483.1 - 4.6 7.0 30.5 4.6 7.0 12.9 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.5 CDI79483.1 - 6.3 4.8 39.1 2.2 6.4 17.8 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal HALZ PF02183.13 CDI79487.1 - 0.089 12.5 4.0 0.075 12.7 0.8 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Pox_A_type_inc PF04508.7 CDI79487.1 - 0.11 12.3 2.1 0.56 10.1 1.5 2.4 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat TSC22 PF01166.13 CDI79487.1 - 0.2 11.6 2.5 0.18 11.7 0.2 2.0 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF2229 PF09989.4 CDI79487.1 - 9.9 5.5 6.2 5.4 6.4 2.7 1.6 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Porin_4 PF13609.1 CDI79488.1 - 0.015 14.8 0.1 0.019 14.4 0.1 1.2 1 0 0 1 1 1 0 Gram-negative porin Topoisom_bac PF01131.15 CDI79489.1 - 2.9e-20 72.4 0.2 2e-14 53.2 0.0 4.2 2 2 1 3 3 3 3 DNA topoisomerase Toprim PF01751.17 CDI79489.1 - 8.6e-08 32.0 0.0 1.9e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Pkinase PF00069.20 CDI79490.1 - 1.4e-38 132.5 0.0 2.1e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79490.1 - 2.5e-20 72.6 0.0 3.6e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_8 PF13833.1 CDI79490.1 - 2.4e-09 36.6 2.2 1.4e-05 24.6 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 CDI79490.1 - 6.4e-09 35.8 0.9 0.00037 20.5 0.0 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 CDI79490.1 - 7e-09 34.8 2.2 0.00026 20.6 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 CDI79490.1 - 1.1e-08 33.7 1.4 0.00088 18.4 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 CDI79490.1 - 4.5e-07 28.9 6.8 0.0018 17.5 0.4 3.1 3 0 0 3 3 3 2 EF hand Kinase-like PF14531.1 CDI79490.1 - 1.5e-05 24.1 0.0 3.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Kinase-like EF-hand_4 PF12763.2 CDI79490.1 - 0.63 9.8 1.9 2.5 7.9 0.1 2.6 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand BAF1_ABF1 PF04684.8 CDI79493.1 - 0.031 13.1 0.2 0.031 13.1 0.1 4.4 4 0 0 4 4 4 0 BAF1 / ABF1 chromatin reorganising factor DUF2036 PF09724.4 CDI79494.1 - 2.1e-07 30.4 0.1 0.0068 15.5 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2036) FAD_binding_3 PF01494.14 CDI79495.1 - 5e-25 88.3 8.4 1.6e-17 63.6 0.0 4.5 5 0 0 5 5 5 2 FAD binding domain Lycopene_cycl PF05834.7 CDI79495.1 - 4.9e-05 22.4 0.1 4.9e-05 22.4 0.0 3.6 4 0 0 4 4 4 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 CDI79495.1 - 0.0016 18.3 0.0 0.0051 16.7 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDI79495.1 - 0.0024 17.0 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.1 CDI79495.1 - 0.004 17.1 0.0 0.004 17.1 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CDI79495.1 - 0.0076 14.7 2.0 0.0097 14.4 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.1 CDI79495.1 - 0.058 13.4 2.4 0.066 13.2 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF605 PF04652.11 CDI79499.1 - 7.8 5.7 27.6 8.9 5.5 19.1 1.0 1 0 0 1 1 1 0 Vta1 like Activator_LAG-3 PF11498.3 CDI79499.1 - 7.8 5.1 31.8 8.3 5.0 22.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Sporozoite_P67 PF05642.6 CDI79501.1 - 0.19 9.5 4.6 0.25 9.1 3.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pex14_N PF04695.8 CDI79501.1 - 0.63 10.0 11.8 0.17 11.9 3.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Di19_C PF14571.1 CDI79501.1 - 1.8 8.9 11.6 2 8.7 1.6 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Macoilin PF09726.4 CDI79501.1 - 3 6.0 6.8 2.9 6.0 1.0 2.0 2 0 0 2 2 2 0 Transmembrane protein DUF4175 PF13779.1 CDI79501.1 - 4.6 4.8 12.5 6.3 4.3 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UPF0560 PF10577.4 CDI79501.1 - 4.9 5.2 8.7 8.4 4.5 6.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TPR_11 PF13414.1 CDI79502.1 - 5.5e-12 45.1 2.4 1.1e-09 37.8 0.2 2.8 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 CDI79502.1 - 3.5e-06 26.3 3.1 0.029 13.9 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI79502.1 - 3.5e-06 26.4 3.3 0.014 15.3 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDI79502.1 - 2.4e-05 24.6 0.5 0.0006 20.1 0.0 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI79502.1 - 0.0052 17.3 2.0 0.59 10.9 0.2 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 CDI79502.1 - 0.0082 16.2 1.7 0.058 13.5 0.5 2.6 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 CDI79502.1 - 0.017 14.8 0.2 3.9 7.4 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDI79502.1 - 0.025 14.5 1.1 0.33 10.9 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 CDI79502.1 - 0.03 14.9 0.1 0.03 14.9 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI79502.1 - 0.031 14.0 0.1 0.2 11.5 0.1 2.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.1 CDI79502.1 - 0.11 12.7 1.4 0.83 10.0 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDI79502.1 - 0.39 11.2 8.3 5.9 7.5 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat Acyl-CoA_dh_1 PF00441.19 CDI79504.1 - 5.2e-15 55.8 0.1 7e-14 52.1 0.1 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain His_Phos_1 PF00300.17 CDI79505.1 - 3.5e-11 43.4 1.7 7.3e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF45 PF01863.12 CDI79505.1 - 0.021 14.6 5.1 0.036 13.8 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 AAA_23 PF13476.1 CDI79505.1 - 0.031 14.5 1.6 0.058 13.7 1.1 1.4 1 0 0 1 1 1 0 AAA domain DUF4411 PF14367.1 CDI79505.1 - 0.16 11.6 3.9 0.33 10.6 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Macoilin PF09726.4 CDI79505.1 - 1.1 7.4 29.2 1.6 6.8 19.8 1.5 1 1 0 1 1 1 0 Transmembrane protein AAA_12 PF13087.1 CDI79506.1 - 9.3e-47 158.9 0.1 9.3e-47 158.9 0.1 6.5 9 0 0 9 9 9 1 AAA domain AAA_11 PF13086.1 CDI79506.1 - 1.5e-32 113.0 16.4 4.1e-17 62.5 0.0 14.0 10 4 1 11 11 11 2 AAA domain SprA-related PF12118.3 CDI79506.1 - 0.0011 18.3 27.5 0.0011 18.3 19.1 20.5 12 5 3 15 15 15 1 SprA-related family PTH2 PF01981.11 CDI79508.1 - 2e-16 59.7 8.4 3.1e-14 52.6 2.6 5.0 1 1 1 3 3 3 2 Peptidyl-tRNA hydrolase PTH2 OmpH PF03938.9 CDI79510.1 - 0.0016 18.4 48.2 0.0059 16.5 16.7 2.4 2 0 0 2 2 2 2 Outer membrane protein (OmpH-like) APC_CDC26 PF10471.4 CDI79510.1 - 0.025 15.3 12.3 0.025 15.3 8.5 4.0 3 1 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 AUX_IAA PF02309.11 CDI79510.1 - 0.92 9.2 11.6 0.077 12.7 1.5 2.3 2 0 0 2 2 2 0 AUX/IAA family TFIIA PF03153.8 CDI79510.1 - 1.4 8.7 32.6 1.2 8.9 6.5 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.11 CDI79510.1 - 2.1 8.1 8.7 8 6.2 6.0 1.8 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nitroreductase PF00881.19 CDI79510.1 - 8.8 6.1 10.8 8.5 6.1 1.9 2.6 2 0 0 2 2 2 0 Nitroreductase family TF_Zn_Ribbon PF08271.7 CDI79511.1 - 4.7e-08 32.2 0.2 4.7e-08 32.2 0.1 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding TFIIB PF00382.14 CDI79511.1 - 1e-06 28.4 0.2 2.9e-06 26.9 0.1 1.8 1 0 0 1 1 1 1 Transcription factor TFIIB repeat TFIIS_M PF07500.9 CDI79512.1 - 5.9e-28 97.2 0.1 9.5e-28 96.5 0.1 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 CDI79512.1 - 4.8e-19 67.7 5.2 8.7e-19 66.8 3.6 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 CDI79512.1 - 1.2e-12 47.1 0.2 2.2e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Macoilin PF09726.4 CDI79512.1 - 0.1 10.8 6.6 0.14 10.4 4.5 1.3 1 0 0 1 1 1 0 Transmembrane protein Elf1 PF05129.8 CDI79512.1 - 0.11 12.2 1.7 0.2 11.3 1.2 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Rabaptin PF03528.10 CDI79512.1 - 0.11 12.4 2.9 0.37 10.7 2.0 1.8 1 1 0 1 1 1 0 Rabaptin CENP-P PF13096.1 CDI79512.1 - 0.13 11.5 0.2 0.23 10.7 0.1 1.3 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P MlrC_C PF07171.7 CDI79512.1 - 2 7.9 6.0 4.2 6.8 1.0 2.2 2 0 0 2 2 2 0 MlrC C-terminus Shadoo PF14999.1 CDI79512.1 - 6 6.7 21.1 0.077 12.8 2.3 2.8 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective Pex14_N PF04695.8 CDI79512.1 - 6.9 6.7 10.1 0.95 9.5 3.3 2.3 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.20 CDI79514.1 - 6e-50 169.8 0.0 9.5e-39 133.1 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79514.1 - 1.7e-18 66.6 0.0 4.7e-12 45.5 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDI79514.1 - 0.00016 20.7 0.0 0.00045 19.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 CDI79514.1 - 0.3 9.8 0.0 0.47 9.2 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Chorein_N PF12624.2 CDI79516.1 - 0.026 14.0 0.0 0.026 14.0 0.0 3.4 3 0 0 3 3 3 0 N-terminal region of Chorein, a TM vesicle-mediated sorter HMG14_17 PF01101.13 CDI79517.1 - 1.5 9.5 9.0 0.37 11.5 4.0 1.7 2 1 0 2 2 2 0 HMG14 and HMG17 PAP1 PF08601.5 CDI79517.1 - 4.3 6.9 7.0 5.5 6.5 4.9 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 HEAT PF02985.17 CDI79518.1 - 0.15 12.2 7.7 1.9 8.7 0.0 5.1 4 0 0 4 4 4 0 HEAT repeat TPR_2 PF07719.12 CDI79519.1 - 6.8e-16 56.8 7.0 0.087 12.7 0.4 7.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 CDI79519.1 - 4.7e-14 51.7 14.2 3.6e-06 26.5 0.5 4.8 4 1 0 4 4 4 4 TPR repeat TPR_1 PF00515.23 CDI79519.1 - 7.5e-09 34.8 0.3 0.97 9.1 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDI79519.1 - 6.2e-08 32.4 13.6 0.02 14.8 0.2 5.0 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 CDI79519.1 - 1.8e-07 31.1 49.7 0.023 15.2 0.0 8.8 5 2 4 9 9 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 CDI79519.1 - 0.00015 21.7 0.5 2.2 8.6 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDI79519.1 - 0.00046 19.7 0.0 1.6 8.6 0.1 4.3 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDI79519.1 - 0.00072 20.1 15.0 0.011 16.4 7.0 6.9 6 1 0 6 6 4 4 Tetratricopeptide repeat TPR_7 PF13176.1 CDI79519.1 - 0.0012 18.4 5.4 0.39 10.6 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDI79519.1 - 0.007 16.2 1.3 0.059 13.2 0.1 5.9 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 CDI79519.1 - 0.013 15.7 0.1 0.013 15.7 0.1 5.4 4 2 2 6 6 5 0 Tetratricopeptide repeat Med15 PF09606.5 CDI79519.1 - 0.23 9.6 25.7 0.34 9.0 17.8 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TPR_6 PF13174.1 CDI79519.1 - 0.55 10.8 0.0 0.55 10.8 0.0 7.1 9 0 0 9 9 7 0 Tetratricopeptide repeat TFIIA PF03153.8 CDI79519.1 - 1.4 8.7 16.7 2.1 8.1 11.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rifin_STEVOR PF02009.11 CDI79519.1 - 1.4 8.4 8.5 2.5 7.6 5.9 1.3 1 0 0 1 1 1 0 Rifin/stevor family Suf PF05843.9 CDI79519.1 - 2.1 8.0 0.0 2.1 8.0 0.0 2.8 2 1 0 2 2 1 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI79519.1 - 5.9 4.9 18.0 7.5 4.6 12.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_LMP2 PF07415.6 CDI79519.1 - 7.8 4.9 7.0 13 4.2 4.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Pkinase_Tyr PF07714.12 CDI79525.1 - 0.0058 15.7 0.0 0.034 13.2 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 CDI79525.1 - 0.0066 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Sec63 PF02889.11 CDI79527.1 - 3.2e-171 568.6 0.0 1.3e-99 333.3 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 CDI79527.1 - 2.4e-41 141.0 3.0 4e-27 94.7 0.1 3.4 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79527.1 - 8e-11 41.6 0.0 1.4e-06 28.0 0.0 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 CDI79527.1 - 2.3e-08 34.1 0.0 6.8e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CDI79527.1 - 7.7e-05 22.8 0.1 0.052 13.6 0.0 3.1 2 1 0 2 2 2 2 AAA domain LepA_C PF06421.7 CDI79530.1 - 9.1e-41 138.1 0.3 1.4e-40 137.5 0.2 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 CDI79530.1 - 2.8e-11 43.1 0.0 6.4e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 CDI79530.1 - 0.011 15.5 0.1 0.22 11.3 0.1 2.4 1 1 0 1 1 1 0 Elongation Factor G, domain II DUF667 PF05018.8 CDI79535.1 - 7.5e-31 106.8 0.0 9.6e-31 106.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Penicil_amidase PF01804.13 CDI79539.1 - 3.1e-53 181.9 0.2 6.5e-15 55.2 0.0 4.3 3 1 1 4 4 4 4 Penicillin amidase zf-U1 PF06220.7 CDI79542.1 - 0.00025 20.5 0.5 0.00063 19.2 0.4 1.7 1 0 0 1 1 1 1 U1 zinc finger BAF1_ABF1 PF04684.8 CDI79542.1 - 0.0021 16.9 12.1 0.0021 16.9 8.4 4.6 4 1 1 5 5 5 1 BAF1 / ABF1 chromatin reorganising factor WW PF00397.21 CDI79542.1 - 0.0027 17.5 0.0 0.0078 16.0 0.0 1.8 1 0 0 1 1 1 1 WW domain CcmB PF03379.8 CDI79542.1 - 0.34 10.0 0.0 0.53 9.4 0.0 1.2 1 0 0 1 1 1 0 CcmB protein Peptidase_M24 PF00557.19 CDI79545.1 - 2.2e-35 122.1 0.0 4.5e-35 121.1 0.0 1.6 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 CDI79545.1 - 1.2e-22 80.8 0.0 1.2e-16 61.3 0.0 2.8 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Acetyltransf_1 PF00583.19 CDI79545.1 - 0.14 12.2 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family MSP1b PF03429.8 CDI79545.1 - 0.18 9.6 2.0 0.27 9.0 1.4 1.1 1 0 0 1 1 1 0 Major surface protein 1B UPF0542 PF15086.1 CDI79545.1 - 0.47 10.1 1.8 1.2 8.8 1.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 FXa_inhibition PF14670.1 CDI79547.1 - 0.0016 18.5 68.0 0.11 12.6 2.7 8.0 6 1 1 7 7 7 6 Coagulation Factor Xa inhibitory site COX3 PF00510.13 CDI79548.1 - 0.18 11.2 0.2 0.28 10.5 0.0 1.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit III PapD-like PF14874.1 CDI79549.1 - 4.3e-14 52.2 2.3 9.5 6.2 0.0 11.5 11 1 1 12 12 12 3 Flagellar-associated PapD-like Motile_Sperm PF00635.21 CDI79549.1 - 1.3e-07 31.1 1.1 2.4 7.8 0.0 8.1 9 0 0 9 9 9 2 MSP (Major sperm protein) domain FixG_C PF11614.3 CDI79549.1 - 6.6e-06 26.2 0.0 1.4 9.0 0.0 5.5 6 0 0 6 6 6 2 IG-like fold at C-terminal of FixG, putative oxidoreductase MYCBPAP PF14646.1 CDI79549.1 - 0.00063 18.5 0.0 7.4 5.1 0.0 4.4 4 1 1 5 5 5 2 MYCBP-associated protein family ATP-synt_C PF00137.16 CDI79550.1 - 2.5e-35 120.1 24.5 1.4e-18 66.5 6.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C IMCp PF12314.3 CDI79551.1 - 2.2e-08 34.1 21.6 2.2e-08 34.1 14.9 4.2 1 1 1 3 3 3 2 Inner membrane complex protein ParA PF10609.4 CDI79552.1 - 4.9e-30 103.2 0.2 3.4e-29 100.5 0.1 2.2 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 CDI79552.1 - 1.1e-15 57.5 0.0 1.7e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF59 PF01883.14 CDI79552.1 - 1.5e-15 56.9 0.0 3.5e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function DUF59 AAA_31 PF13614.1 CDI79552.1 - 5.1e-09 36.2 0.2 4.4e-08 33.2 0.0 2.4 3 0 0 3 3 3 1 AAA domain MipZ PF09140.6 CDI79552.1 - 5.5e-06 25.6 0.0 1.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 ATPase MipZ DUF971 PF06155.7 CDI79552.1 - 0.00024 21.4 0.0 0.00062 20.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF971) VirC1 PF07015.6 CDI79552.1 - 0.0057 15.7 0.1 0.0096 15.0 0.0 1.3 1 0 0 1 1 1 1 VirC1 protein ArsA_ATPase PF02374.10 CDI79552.1 - 0.0085 15.1 0.5 0.24 10.3 0.1 2.3 2 0 0 2 2 2 1 Anion-transporting ATPase APS_kinase PF01583.15 CDI79552.1 - 0.043 13.4 0.0 0.083 12.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_25 PF13481.1 CDI79552.1 - 0.058 12.7 0.1 0.47 9.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain ArgK PF03308.11 CDI79552.1 - 0.13 11.0 0.1 0.22 10.2 0.1 1.3 1 0 0 1 1 1 0 ArgK protein SRP54 PF00448.17 CDI79552.1 - 0.17 11.3 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NTP_transf_5 PF14907.1 CDI79553.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase Rab5-bind PF09311.6 CDI79553.1 - 0.13 12.1 0.3 0.28 11.0 0.2 1.6 2 0 0 2 2 2 0 Rabaptin-like protein OTU PF02338.14 CDI79555.1 - 4.4e-13 49.8 0.0 8.6e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease zf-RING_2 PF13639.1 CDI79556.1 - 4e-06 26.5 14.3 4e-06 26.5 9.9 2.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDI79556.1 - 7.1e-05 22.3 10.6 7.1e-05 22.3 7.3 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI79556.1 - 7.8e-05 22.6 13.9 7.8e-05 22.6 9.6 3.1 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI79556.1 - 0.00023 20.7 14.2 0.00023 20.7 9.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDI79556.1 - 0.0021 17.8 12.5 0.0092 15.8 8.7 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CDI79556.1 - 0.0049 16.5 14.3 0.0049 16.5 9.9 2.8 3 1 0 3 3 3 1 zinc-RING finger domain zf-TRAF PF02176.13 CDI79556.1 - 0.0092 16.3 5.7 0.0092 16.3 3.9 3.8 2 1 2 4 4 3 1 TRAF-type zinc finger Sina PF03145.11 CDI79556.1 - 0.0098 15.5 22.0 0.044 13.4 1.9 4.4 2 1 3 5 5 5 4 Seven in absentia protein family zf-Apc11 PF12861.2 CDI79556.1 - 0.0099 15.7 5.2 0.0099 15.7 3.6 2.3 2 1 1 3 3 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 CDI79556.1 - 0.014 15.4 6.7 0.014 15.4 4.6 2.6 2 1 0 2 2 1 0 RING-H2 zinc finger Menin PF05053.8 CDI79556.1 - 0.17 10.0 1.9 0.25 9.4 1.3 1.2 1 0 0 1 1 1 0 Menin zf-RING_UBOX PF13445.1 CDI79556.1 - 1.4 8.7 13.0 0.31 10.8 5.4 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Voltage_CLC PF00654.15 CDI79557.1 - 2.1e-31 109.2 33.7 3.6e-15 55.8 4.3 4.9 5 1 1 6 6 6 4 Voltage gated chloride channel zf-CCCH PF00642.19 CDI79558.1 - 3.7e-10 39.2 11.1 5.6e-07 29.0 0.9 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CDI79558.1 - 3.1 7.9 10.8 0.38 10.8 1.2 3.3 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type PAT1 PF09770.4 CDI79559.1 - 4.3 5.4 40.0 0.31 9.2 15.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Cir_N PF10197.4 CDI79560.1 - 7.9e-13 48.2 12.5 7.9e-13 48.2 8.7 3.6 4 1 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR APG6 PF04111.7 CDI79560.1 - 0.0093 15.0 10.6 0.013 14.5 7.3 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 BTK PF00779.14 CDI79560.1 - 0.55 9.8 4.7 1.8 8.2 0.9 2.5 2 0 0 2 2 2 0 BTK motif Borrelia_P83 PF05262.6 CDI79560.1 - 2.4 6.3 15.1 3.1 5.9 10.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein HSP70 PF00012.15 CDI79560.1 - 2.7 5.8 10.2 4 5.2 7.0 1.2 1 0 0 1 1 1 0 Hsp70 protein DEAD PF00270.24 CDI79561.1 - 6.1e-26 90.9 0.0 5.4e-25 87.8 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79561.1 - 9.5e-17 60.6 0.0 2.2e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain EF-hand_6 PF13405.1 CDI79562.1 - 1.6e-11 43.0 0.0 0.00012 21.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 CDI79562.1 - 1.6e-11 42.5 0.0 0.00012 21.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 CDI79562.1 - 5.3e-10 39.3 0.0 0.0002 21.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 CDI79562.1 - 1.5e-05 24.4 0.0 0.022 14.3 0.0 3.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 CDI79562.1 - 2.4e-05 24.1 0.0 0.11 12.4 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 CDI79562.1 - 0.0013 17.9 0.0 1.2 8.6 0.0 2.5 2 0 0 2 2 2 2 EF hand IBR PF01485.16 CDI79564.1 - 7e-17 61.0 35.0 2.6e-08 33.6 5.9 4.4 4 1 0 4 4 4 2 IBR domain zf-RING_2 PF13639.1 CDI79564.1 - 4.5 7.1 28.9 0.18 11.6 8.9 3.8 3 1 0 3 3 3 0 Ring finger domain PPDK_N PF01326.14 CDI79565.1 - 9.4e-23 80.7 0.0 1.4e-20 73.6 0.0 4.0 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PAT1 PF09770.4 CDI79566.1 - 0.15 10.2 55.1 0.19 9.9 38.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI79566.1 - 5.5 5.0 61.6 7.3 4.6 42.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Pro_isomerase PF00160.16 CDI79569.1 - 1.8e-27 96.4 0.0 5.4e-27 94.9 0.0 1.8 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 CDI79569.1 - 2.8e-16 58.8 0.0 5.5e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79569.1 - 1.1e-11 44.4 0.1 3.1e-11 43.0 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI79569.1 - 1.1e-07 31.6 0.1 2.2e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CDI79569.1 - 0.0045 16.8 0.7 0.017 14.9 0.5 2.1 1 0 0 1 1 1 1 RNA binding motif TFIIA PF03153.8 CDI79570.1 - 0.64 9.8 10.2 0.81 9.5 7.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ATG22 PF11700.3 CDI79572.1 - 0.044 12.2 1.1 0.14 10.5 0.8 1.8 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like EF-hand_1 PF00036.27 CDI79573.1 - 3.4e-06 25.9 0.5 8.3e-06 24.7 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 CDI79573.1 - 3.6e-06 26.4 0.4 1e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 CDI79573.1 - 7e-06 26.0 0.1 1.6e-05 24.9 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 CDI79573.1 - 0.00028 20.0 0.0 0.00059 19.0 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_9 PF14658.1 CDI79573.1 - 0.038 13.8 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain ABC_tran PF00005.22 CDI79574.1 - 7.8e-48 162.2 0.0 1.2e-25 90.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 CDI79574.1 - 2.5e-19 69.5 27.0 2.5e-13 49.8 0.0 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.1 CDI79574.1 - 1.1e-16 61.6 1.9 2.5e-08 34.2 0.0 4.2 4 0 0 4 4 4 3 AAA domain AAA_29 PF13555.1 CDI79574.1 - 1.2e-05 24.6 1.8 0.037 13.5 0.1 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain SMC_N PF02463.14 CDI79574.1 - 0.0011 18.1 0.2 5.6 6.1 0.0 3.7 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 CDI79574.1 - 0.0023 17.1 1.1 0.021 14.0 0.1 2.5 3 0 0 3 3 3 1 Protein of unknown function, DUF258 SbcCD_C PF13558.1 CDI79574.1 - 0.0035 17.2 0.0 0.81 9.6 0.0 2.7 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.1 CDI79574.1 - 0.0074 16.6 5.8 0.02 15.2 0.1 2.7 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 CDI79574.1 - 0.028 13.8 0.2 1.9 7.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain ArgK PF03308.11 CDI79574.1 - 0.28 9.9 0.8 1 8.0 0.2 2.0 2 0 0 2 2 2 0 ArgK protein AAA_30 PF13604.1 CDI79574.1 - 0.37 10.3 0.2 22 4.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.1 CDI79574.1 - 0.39 9.7 0.0 8.3 5.3 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain SRP54 PF00448.17 CDI79574.1 - 0.46 9.8 0.7 4.7 6.5 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain KAP_NTPase PF07693.9 CDI79574.1 - 0.57 9.1 0.0 8.2 5.3 0.0 2.1 2 0 0 2 2 2 0 KAP family P-loop domain DUF87 PF01935.12 CDI79574.1 - 0.86 9.3 4.6 0.26 11.0 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF87 MMR_HSR1 PF01926.18 CDI79574.1 - 1.1 9.1 4.7 1.4 8.9 0.5 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_10 PF12846.2 CDI79574.1 - 3.1 7.1 4.6 4.3 6.6 0.4 2.2 2 0 0 2 2 2 0 AAA-like domain RinB PF06116.7 CDI79576.1 - 0.087 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Transcriptional activator RinB ETC_C1_NDUFA4 PF04800.7 CDI79576.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 ETC complex I subunit conserved region CDK2AP PF09806.4 CDI79579.1 - 0.0022 18.2 0.4 0.0022 18.2 0.3 10.9 5 4 0 6 6 6 1 Cyclin-dependent kinase 2-associated protein BAF1_ABF1 PF04684.8 CDI79579.1 - 0.0029 16.5 8.4 0.0029 16.5 5.9 8.7 10 0 0 10 10 10 2 BAF1 / ABF1 chromatin reorganising factor YtxH PF12732.2 CDI79580.1 - 0.0007 19.9 17.7 0.056 13.8 1.8 2.7 1 1 1 2 2 2 2 YtxH-like protein DUF883 PF05957.8 CDI79580.1 - 0.0048 17.2 20.7 1.1 9.6 4.7 2.8 1 1 2 3 3 3 3 Bacterial protein of unknown function (DUF883) LEA_4 PF02987.11 CDI79580.1 - 0.0073 16.1 29.9 0.027 14.3 3.1 4.1 2 1 2 4 4 4 2 Late embryogenesis abundant protein AD PF09793.4 CDI79580.1 - 0.035 13.9 0.3 0.035 13.9 0.2 2.4 1 1 2 3 3 3 0 Anticodon-binding domain CAP160 PF07918.6 CDI79580.1 - 0.095 12.3 1.2 0.095 12.3 0.8 2.9 3 0 0 3 3 3 0 CAP160 repeat Apolipoprotein PF01442.13 CDI79580.1 - 0.65 9.4 6.9 5.6 6.4 0.1 2.0 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain WXG100 PF06013.7 CDI79580.1 - 1.1 9.2 10.4 3.1 7.8 1.8 2.6 1 1 0 2 2 2 0 Proteins of 100 residues with WXG Exonuc_VII_L PF02601.10 CDI79580.1 - 3.2 6.8 9.5 1 8.4 1.0 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit Stomoxyn PF11585.3 CDI79580.1 - 3.5 7.4 9.0 2.2 8.1 0.1 3.0 2 1 1 3 3 3 0 Insect antimicrobial peptide, stomoxyn DUF3337 PF11816.3 CDI79580.1 - 5 6.4 7.9 6.2 6.1 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Mnd1 PF03962.10 CDI79580.1 - 6.3 6.4 7.9 7.8 6.1 5.5 1.3 1 0 0 1 1 1 0 Mnd1 family Synuclein PF01387.12 CDI79580.1 - 8 6.3 15.1 19 5.1 7.7 2.2 1 1 1 2 2 2 0 Synuclein DNA_ligase_A_M PF01068.16 CDI79582.1 - 1.1e-22 80.4 0.0 3.4e-22 78.7 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_IV PF11411.3 CDI79582.1 - 0.00042 19.9 0.1 0.0013 18.4 0.0 1.8 1 0 0 1 1 1 1 DNA ligase IV DUF374 PF04028.8 CDI79582.1 - 0.034 13.3 1.8 0.18 11.0 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF374) BRCT PF00533.21 CDI79582.1 - 0.04 14.0 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain IncA PF04156.9 CDI79584.1 - 4.4e-06 26.4 14.5 4.4e-06 26.4 10.0 11.0 4 2 8 12 12 12 1 IncA protein SAPS PF04499.10 CDI79585.1 - 0.033 12.8 16.9 0.08 11.5 5.7 3.0 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein PCI PF01399.22 CDI79587.1 - 2.2e-11 43.9 0.1 7e-11 42.3 0.0 1.7 1 1 0 1 1 1 1 PCI domain DUF2042 PF09743.4 CDI79587.1 - 0.034 13.4 0.0 0.038 13.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2042) HTH_Mga PF08280.6 CDI79587.1 - 0.15 11.8 0.9 0.33 10.7 0.6 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain FimP PF09766.4 CDI79588.1 - 0.00042 19.4 7.2 0.00046 19.3 5.0 1.1 1 0 0 1 1 1 1 Fms-interacting protein U79_P34 PF03064.11 CDI79588.1 - 0.0033 17.0 1.0 0.0037 16.8 0.7 1.1 1 0 0 1 1 1 1 HSV U79 / HCMV P34 VIT1 PF01988.14 CDI79588.1 - 0.011 15.2 8.1 0.014 14.8 5.6 1.2 1 0 0 1 1 1 0 VIT family DUF3260 PF11658.3 CDI79588.1 - 0.023 12.8 7.8 0.027 12.6 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Peptidase_S49_N PF08496.5 CDI79588.1 - 0.034 13.9 5.3 0.045 13.5 3.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_M16_C PF05193.16 CDI79588.1 - 0.043 13.4 1.3 0.053 13.1 0.9 1.1 1 0 0 1 1 1 0 Peptidase M16 inactive domain ADP_ribosyl_GH PF03747.9 CDI79588.1 - 0.069 12.9 7.9 0.078 12.7 5.5 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase FHIPEP PF00771.15 CDI79588.1 - 0.088 11.1 5.4 0.099 10.9 3.7 1.0 1 0 0 1 1 1 0 FHIPEP family Spt20 PF12090.3 CDI79588.1 - 0.095 12.0 4.8 0.13 11.6 3.4 1.4 1 0 0 1 1 1 0 Spt20 family OATP PF03137.15 CDI79588.1 - 0.097 10.7 1.2 0.11 10.4 0.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2217 PF10265.4 CDI79588.1 - 0.14 10.8 7.9 0.16 10.7 5.4 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Activator_LAG-3 PF11498.3 CDI79588.1 - 0.16 10.6 31.3 0.21 10.3 21.7 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Shisa PF13908.1 CDI79588.1 - 0.17 12.0 9.4 0.22 11.6 6.5 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4557 PF15101.1 CDI79588.1 - 0.18 11.6 14.2 0.19 11.5 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF4446 PF14584.1 CDI79588.1 - 0.19 11.5 2.0 0.24 11.2 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Serinc PF03348.10 CDI79588.1 - 0.19 10.3 5.7 0.21 10.2 4.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) PAT1 PF09770.4 CDI79588.1 - 0.2 9.8 24.3 0.21 9.7 16.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S15 PF02129.13 CDI79588.1 - 0.23 10.8 8.0 0.27 10.6 5.6 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DDHD PF02862.12 CDI79588.1 - 0.24 11.1 5.5 0.25 11.0 3.8 1.1 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.5 CDI79588.1 - 0.27 9.3 36.9 0.28 9.3 25.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal UPF0560 PF10577.4 CDI79588.1 - 0.36 9.0 16.3 0.4 8.8 11.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 AIF_C PF14721.1 CDI79588.1 - 0.36 11.0 5.2 0.44 10.7 3.6 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Neur_chan_memb PF02932.11 CDI79588.1 - 0.42 10.4 4.5 0.43 10.4 3.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.5 CDI79588.1 - 0.58 10.1 13.7 0.64 10.0 9.5 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Band_3_cyto PF07565.8 CDI79588.1 - 0.71 9.3 7.0 0.76 9.2 4.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Hid1 PF12722.2 CDI79588.1 - 0.82 7.2 11.6 0.92 7.1 8.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SHR3_chaperone PF08229.6 CDI79588.1 - 0.97 8.3 5.2 1.1 8.1 3.6 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 Baculo_PP31 PF05311.6 CDI79588.1 - 1.2 8.3 8.4 1.3 8.2 5.8 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Suf PF05843.9 CDI79588.1 - 1.5 8.4 11.2 1.7 8.2 7.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Paramyxo_ncap PF00973.14 CDI79588.1 - 1.7 7.2 10.3 2 7.0 7.1 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AUX_IAA PF02309.11 CDI79588.1 - 2 8.1 8.7 2.2 8.0 6.0 1.1 1 0 0 1 1 1 0 AUX/IAA family YppG PF14179.1 CDI79588.1 - 2.4 8.7 25.3 3.3 8.3 17.6 1.1 1 0 0 1 1 1 0 YppG-like protein IncA PF04156.9 CDI79588.1 - 2.7 7.5 21.8 4.2 6.9 15.1 1.4 1 1 0 1 1 1 0 IncA protein DUF3373 PF11853.3 CDI79588.1 - 3.4 6.0 9.0 3.9 5.8 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Gag_spuma PF03276.9 CDI79588.1 - 3.7 5.7 20.3 4.2 5.5 14.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Pex16 PF08610.5 CDI79588.1 - 3.8 6.4 7.5 4.2 6.2 5.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) TFIIA PF03153.8 CDI79588.1 - 4.6 7.0 22.9 4.9 6.9 15.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.1 CDI79588.1 - 4.7 6.8 9.3 5.1 6.7 6.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DDRGK PF09756.4 CDI79588.1 - 4.9 6.5 15.0 5.5 6.3 10.4 1.1 1 0 0 1 1 1 0 DDRGK domain eIF-3_zeta PF05091.7 CDI79588.1 - 5.4 5.5 13.3 5.8 5.4 9.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Med13_N PF11597.3 CDI79588.1 - 6.3 5.3 11.5 7.1 5.1 7.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal DivIC PF04977.10 CDI79588.1 - 7 6.2 14.6 11 5.5 10.1 1.3 1 0 0 1 1 1 0 Septum formation initiator DNA_pol_viral_N PF00242.12 CDI79588.1 - 8.4 5.3 13.2 8.8 5.2 9.2 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Glyco_transf_15 PF01793.11 CDI79588.1 - 9.7 5.0 9.0 11 4.7 6.2 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase SWIM PF04434.12 CDI79592.1 - 0.0024 17.3 0.4 0.0024 17.3 0.3 2.4 2 0 0 2 2 2 1 SWIM zinc finger SOBP PF15279.1 CDI79592.1 - 0.097 13.0 16.6 0.15 12.4 11.5 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.4 CDI79592.1 - 0.53 8.4 33.9 0.014 13.7 19.4 1.4 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 LMBR1 PF04791.11 CDI79592.1 - 0.69 8.4 4.0 1.1 7.7 2.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIA PF03153.8 CDI79592.1 - 1.7 8.4 31.3 0.11 12.3 15.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RCR PF12273.3 CDI79592.1 - 4.3 7.8 21.3 0.34 11.4 11.1 1.8 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red DUF1395 PF07160.7 CDI79592.1 - 5.7 6.3 11.4 12 5.3 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1395) RAP1 PF07218.6 CDI79596.1 - 0.0098 14.0 0.2 0.0098 14.0 0.2 3.2 3 0 0 3 3 3 1 Rhoptry-associated protein 1 (RAP-1) SIR2_2 PF13289.1 CDI79596.1 - 0.2 11.5 0.0 0.2 11.5 0.0 2.3 3 0 0 3 3 3 0 SIR2-like domain N6_N4_Mtase PF01555.13 CDI79596.1 - 3.4 7.0 5.6 5.6 6.3 1.1 2.5 3 0 0 3 3 3 0 DNA methylase SR-25 PF10500.4 CDI79597.1 - 0.0019 17.6 2.0 0.0019 17.6 1.4 9.3 7 3 2 9 9 9 2 Nuclear RNA-splicing-associated protein Pex14_N PF04695.8 CDI79597.1 - 0.0088 16.0 15.1 0.0088 16.0 10.5 10.7 6 3 1 7 7 7 2 Peroxisomal membrane anchor protein (Pex14p) conserved region AdoMet_MTase PF07757.8 CDI79597.1 - 0.21 11.7 0.5 0.6 10.2 0.0 1.9 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase Nucleoplasmin PF03066.10 CDI79599.1 - 1.1 8.7 13.1 2 7.9 0.3 2.2 2 0 0 2 2 2 0 Nucleoplasmin DUF605 PF04652.11 CDI79599.1 - 4.5 6.5 36.8 4.9 6.4 25.5 1.1 1 0 0 1 1 1 0 Vta1 like Glycos_transf_2 PF00535.21 CDI79600.1 - 1.6e-24 86.4 0.0 2.6e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 CDI79600.1 - 8.6e-09 34.8 0.0 3.5e-08 32.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.9 CDI79600.1 - 6.4e-07 28.7 0.5 1.4e-06 27.6 0.2 1.7 1 1 1 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.1 CDI79600.1 - 1.4e-06 28.3 0.0 1.4e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 TFIIF_alpha PF05793.7 CDI79600.1 - 4.3 5.6 22.7 6.9 4.9 15.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PLRV_ORF5 PF01690.12 CDI79600.1 - 5.1 6.1 14.1 7.3 5.6 9.8 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Daxx PF03344.10 CDI79600.1 - 7.2 4.9 19.7 11 4.4 13.7 1.1 1 0 0 1 1 1 0 Daxx Family Pkinase PF00069.20 CDI79602.1 - 3.9e-53 180.2 0.0 7.3e-53 179.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79602.1 - 1e-23 83.7 0.0 3.1e-23 82.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.17 CDI79602.1 - 0.0058 15.9 0.1 0.033 13.5 0.0 2.2 1 1 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.6 CDI79602.1 - 0.21 10.3 0.0 0.32 9.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase GET2 PF08690.5 CDI79602.1 - 0.4 9.8 1.5 0.78 8.9 1.0 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 ubiquitin PF00240.18 CDI79604.1 - 1.8e-23 81.6 0.4 2e-23 81.5 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CDI79604.1 - 4.3e-14 51.9 0.2 4.6e-14 51.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDI79604.1 - 0.00014 22.0 0.0 0.00014 22.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CDI79604.1 - 0.019 14.6 0.0 0.02 14.5 0.0 1.0 1 0 0 1 1 1 0 Telomere stability and silencing TUG-UBL1 PF11470.3 CDI79604.1 - 0.027 14.3 0.0 0.029 14.3 0.0 1.0 1 0 0 1 1 1 0 GLUT4 regulating protein TUG DUF2407 PF10302.4 CDI79604.1 - 0.11 12.6 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain MS_channel PF00924.13 CDI79605.1 - 2e-15 56.7 1.2 2e-15 56.7 0.8 3.1 2 1 0 2 2 2 1 Mechanosensitive ion channel TIM PF00121.13 CDI79606.1 - 6.3e-85 284.1 3.3 5.9e-81 271.1 1.0 2.0 2 0 0 2 2 2 2 Triosephosphate isomerase RAP PF08373.5 CDI79608.1 - 2.9e-05 23.7 1.4 0.0065 16.2 0.1 3.5 3 0 0 3 3 3 2 RAP domain WD40 PF00400.27 CDI79609.1 - 0.00029 20.6 0.1 0.00043 20.0 0.1 1.3 1 0 0 1 1 1 1 WD domain, G-beta repeat Ribos_L4_asso_C PF14374.1 CDI79609.1 - 0.02 14.7 1.5 0.03 14.2 1.0 1.2 1 0 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain COX14 PF14880.1 CDI79609.1 - 0.83 9.3 5.1 7.9 6.1 0.6 2.3 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Med3 PF11593.3 CDI79609.1 - 5.3 6.1 6.3 6.5 5.8 4.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pyr_redox PF00070.22 CDI79610.1 - 1.1e-10 41.7 0.1 4.1e-08 33.5 0.0 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CDI79610.1 - 1.1e-06 28.6 11.6 7.5e-06 25.9 0.0 3.5 2 1 2 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.17 CDI79610.1 - 0.03 14.0 4.8 0.41 10.4 0.0 3.6 4 0 0 4 4 4 0 Thiamine pyrophosphate enzyme, central domain NAD_binding_8 PF13450.1 CDI79610.1 - 0.42 10.6 0.0 0.42 10.6 0.0 4.0 4 0 0 4 4 4 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CDI79610.1 - 0.53 10.3 5.6 0.68 9.9 0.0 2.7 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase CAF-1_p150 PF11600.3 CDI79611.1 - 0.07 12.5 42.6 0.11 11.8 29.5 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF605 PF04652.11 CDI79611.1 - 0.097 12.0 38.5 0.11 11.8 26.7 1.1 1 0 0 1 1 1 0 Vta1 like Hid1 PF12722.2 CDI79611.1 - 0.16 9.6 32.7 0.2 9.3 22.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FliP PF00813.15 CDI79611.1 - 0.37 10.4 6.9 0.74 9.4 4.8 1.7 1 1 0 1 1 1 0 FliP family SOBP PF15279.1 CDI79611.1 - 0.52 10.6 30.5 0.63 10.3 21.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3337 PF11816.3 CDI79611.1 - 0.81 9.0 22.0 1.1 8.5 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) CDC27 PF09507.5 CDI79611.1 - 1.4 8.0 37.0 1.8 7.6 25.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PAT1 PF09770.4 CDI79611.1 - 1.5 6.9 57.4 1.7 6.7 39.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI79611.1 - 1.8 8.3 47.8 2.2 8.1 33.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Draxin PF15550.1 CDI79611.1 - 1.9 8.0 25.2 2.3 7.7 17.5 1.2 1 0 0 1 1 1 0 Draxin UCH PF00443.24 CDI79612.1 - 5.3e-42 143.7 0.0 3.5e-41 141.0 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDI79612.1 - 1.9e-19 70.2 0.0 1.1e-10 41.4 0.0 2.7 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase FliM PF02154.10 CDI79612.1 - 0.04 13.5 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM TctB PF07331.6 CDI79613.1 - 0.0018 17.9 2.9 0.038 13.6 1.0 2.4 2 0 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family DUF2371 PF10177.4 CDI79613.1 - 0.012 15.5 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Conotoxin PF02950.12 CDI79613.1 - 0.16 12.7 1.7 1.3 9.8 0.0 2.8 3 0 0 3 3 3 0 Conotoxin Epimerase PF01370.16 CDI79614.1 - 7.6e-64 215.3 0.0 9.4e-64 215.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CDI79614.1 - 5.9e-11 41.7 0.0 8.4e-11 41.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 CDI79614.1 - 2.1e-05 23.5 0.0 3.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 CDI79614.1 - 0.0035 17.3 0.0 0.0065 16.4 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CDI79614.1 - 0.004 16.4 0.1 0.0064 15.7 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family Pol_alpha_B_N PF08418.5 CDI79616.1 - 0.88 9.0 8.5 0.43 10.0 3.3 2.1 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal His_Phos_2 PF00328.17 CDI79617.1 - 9.9e-13 48.1 7.8 1.2e-12 47.8 2.7 3.8 3 1 0 3 3 3 2 Histidine phosphatase superfamily (branch 2) Adaptin_binding PF10199.4 CDI79617.1 - 0.0017 18.6 7.5 0.0017 18.6 5.2 3.6 2 2 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 SID-1_RNA_chan PF13965.1 CDI79617.1 - 7.6 4.5 4.7 13 3.8 3.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ELMO_CED12 PF04727.8 CDI79618.1 - 5.9e-13 48.7 0.1 5.5e-11 42.3 0.0 2.5 2 1 0 2 2 2 2 ELMO/CED-12 family FluMu_gp41 PF10109.4 CDI79620.1 - 0.086 12.7 0.3 2.1 8.3 0.0 3.0 2 1 0 2 2 2 0 Mu-like prophage FluMu protein gp41 PAT1 PF09770.4 CDI79621.1 - 0.0056 14.9 101.7 0.0086 14.3 70.5 1.3 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Utp14 PF04615.8 CDI79621.1 - 2.6 6.1 45.5 3.4 5.7 31.6 1.1 1 0 0 1 1 1 0 Utp14 protein Aminotran_5 PF00266.14 CDI79623.1 - 2.7e-37 128.3 0.0 3.7e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V CoA_binding_2 PF13380.1 CDI79623.1 - 0.0043 17.1 0.0 0.036 14.2 0.0 2.4 2 0 0 2 2 2 1 CoA binding domain Pyridoxal_deC PF00282.14 CDI79623.1 - 0.0069 14.8 0.2 0.61 8.4 0.0 2.2 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain FimP PF09766.4 CDI79623.1 - 0.0071 15.4 0.1 0.0095 15.0 0.1 1.2 1 0 0 1 1 1 1 Fms-interacting protein adh_short_C2 PF13561.1 CDI79625.1 - 6.2e-88 294.6 3.9 1.3e-76 257.5 0.3 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Enoyl_reductase PF12241.3 CDI79625.1 - 0.0024 16.9 0.2 0.27 10.1 0.0 2.3 1 1 1 2 2 2 2 Trans-2-enoyl-CoA reductase catalytic region SOG2 PF10428.4 CDI79625.1 - 0.078 11.6 7.7 0.026 13.1 0.5 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein Ferrochelatase PF00762.14 CDI79625.1 - 0.081 11.8 0.0 0.15 10.9 0.0 1.4 1 0 0 1 1 1 0 Ferrochelatase Es2 PF09751.4 CDI79626.1 - 1.8e-20 73.7 61.7 9.6e-11 41.7 0.9 4.6 3 3 3 6 6 6 3 Nuclear protein Es2 ORC5_C PF14630.1 CDI79627.1 - 6.7e-09 35.6 0.0 6.7e-09 35.6 0.0 3.5 3 0 0 3 3 3 1 Origin recognition complex (ORC) subunit 5 C-terminus DUF2791 PF10923.3 CDI79627.1 - 0.00012 20.8 0.1 0.00012 20.8 0.1 1.5 2 0 0 2 2 2 1 P-loop Domain of unknown function (DUF2791) ABC_tran PF00005.22 CDI79627.1 - 0.00035 20.8 3.2 0.00091 19.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter NB-ARC PF00931.17 CDI79627.1 - 0.0013 17.7 0.0 0.0023 16.8 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 CDI79627.1 - 0.0064 16.6 0.2 0.0064 16.6 0.2 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDI79627.1 - 0.01 15.7 0.3 0.01 15.7 0.2 3.4 3 1 0 3 3 3 0 AAA domain Spt20 PF12090.3 CDI79627.1 - 0.082 12.2 19.4 1.3 8.3 0.2 3.2 3 0 0 3 3 3 0 Spt20 family DEAD PF00270.24 CDI79628.1 - 5e-34 117.2 0.9 1.1e-33 116.0 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79628.1 - 4.1e-21 74.6 0.0 4.1e-21 74.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI79628.1 - 3.3e-05 23.8 0.0 3.3e-05 23.8 0.0 3.6 3 2 1 4 4 4 1 Type III restriction enzyme, res subunit Spt20 PF12090.3 CDI79628.1 - 0.038 13.3 0.2 0.038 13.3 0.2 3.0 2 1 0 2 2 2 0 Spt20 family AAA_22 PF13401.1 CDI79628.1 - 0.076 13.1 9.8 0.14 12.3 0.0 5.0 4 2 0 4 4 4 0 AAA domain KdgT PF03812.8 CDI79628.1 - 0.65 9.0 2.8 1.3 8.1 1.9 1.3 1 0 0 1 1 1 0 2-keto-3-deoxygluconate permease PPR_3 PF13812.1 CDI79628.1 - 0.89 10.0 4.5 0.88 10.0 0.6 2.9 2 0 0 2 2 2 0 Pentatricopeptide repeat domain AP2 PF00847.15 CDI79629.1 - 1.3e-06 28.4 0.7 1.3e-06 28.4 0.5 3.9 4 0 0 4 4 4 1 AP2 domain Cellulose_synt PF03552.9 CDI79630.1 - 7.1 4.7 6.0 20 3.2 4.1 1.8 1 0 0 1 1 1 0 Cellulose synthase His_Phos_1 PF00300.17 CDI79631.1 - 2.2e-42 144.8 0.0 3.5e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ribosomal_S7 PF00177.16 CDI79635.1 - 1.3e-24 86.4 0.0 2.2e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e CS PF04969.11 CDI79636.1 - 1.5e-07 31.8 0.0 2.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 CS domain IMCp PF12314.3 CDI79637.1 - 2e-06 27.8 60.6 0.039 14.0 24.6 3.7 1 1 2 3 3 3 3 Inner membrane complex protein PAT1 PF09770.4 CDI79638.1 - 3.8 5.6 66.0 4.7 5.3 45.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1120 PF06551.7 CDI79638.1 - 7.4 6.9 6.5 1.2 9.4 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1120) BRF1 PF07741.8 CDI79639.1 - 0.021 15.0 3.3 0.027 14.6 2.3 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF4647 PF15504.1 CDI79640.1 - 0.079 11.8 13.3 0.081 11.7 9.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DNA_pol_viral_N PF00242.12 CDI79640.1 - 0.23 10.4 35.4 0.27 10.2 24.6 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF1510 PF07423.6 CDI79640.1 - 0.45 9.8 10.6 0.61 9.4 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF572 PF04502.8 CDI79640.1 - 0.45 9.6 19.2 0.49 9.5 13.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Pex16 PF08610.5 CDI79640.1 - 0.62 8.9 14.2 0.79 8.6 9.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF566 PF04484.7 CDI79640.1 - 1.3 8.4 34.1 1.6 8.1 23.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) Neur_chan_memb PF02932.11 CDI79640.1 - 1.3 8.8 13.3 1.6 8.5 9.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.9 CDI79640.1 - 1.4 6.8 16.1 1.6 6.6 11.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.6 CDI79640.1 - 1.8 6.3 22.8 2 6.1 15.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Prog_receptor PF02161.10 CDI79640.1 - 2 7.1 21.1 2.4 6.8 14.6 1.0 1 0 0 1 1 1 0 Progesterone receptor DivIC PF04977.10 CDI79640.1 - 2.1 7.8 8.0 3 7.4 5.5 1.2 1 0 0 1 1 1 0 Septum formation initiator SLD3 PF08639.5 CDI79640.1 - 2.2 6.8 29.1 2.3 6.7 20.2 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 MIP-T3 PF10243.4 CDI79640.1 - 2.4 6.5 25.6 2.8 6.3 17.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF4175 PF13779.1 CDI79640.1 - 2.9 5.4 18.7 3.2 5.3 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SAPS PF04499.10 CDI79640.1 - 3.4 6.2 11.9 3.7 6.0 8.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SpoIIIAH PF12685.2 CDI79640.1 - 3.6 7.0 12.4 4.1 6.8 8.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Hid1 PF12722.2 CDI79640.1 - 4.6 4.8 22.3 5 4.6 15.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.4 CDI79640.1 - 6.1 4.9 37.0 7.5 4.7 25.7 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1675 PF07897.6 CDI79640.1 - 6.7 6.4 27.5 9.3 6.0 19.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Spc7_N PF15402.1 CDI79640.1 - 9 4.1 28.5 10 4.0 19.8 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PAT1 PF09770.4 CDI79641.1 - 0.11 10.7 34.1 0.11 10.6 23.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprA-related PF12118.3 CDI79641.1 - 0.23 10.7 36.0 0.31 10.3 24.9 1.1 1 0 0 1 1 1 0 SprA-related family RAB3GAP2_N PF14655.1 CDI79641.1 - 0.27 10.1 6.8 0.43 9.5 4.7 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus FimP PF09766.4 CDI79641.1 - 0.42 9.6 11.1 0.56 9.2 7.7 1.1 1 0 0 1 1 1 0 Fms-interacting protein SAGA-Tad1 PF12767.2 CDI79641.1 - 1.1 8.8 18.8 1.5 8.3 13.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF605 PF04652.11 CDI79641.1 - 3.3 6.9 43.5 4.5 6.5 30.2 1.2 1 0 0 1 1 1 0 Vta1 like NARP1 PF12569.3 CDI79641.1 - 3.5 6.2 7.7 4.6 5.8 5.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4175 PF13779.1 CDI79641.1 - 5.5 4.5 22.6 6.8 4.2 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.8 CDI79641.1 - 8.8 6.1 33.5 10 5.9 23.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SAPS PF04499.10 CDI79642.1 - 0.00084 18.0 11.3 4.3 5.8 12.2 2.4 2 1 0 2 2 2 2 SIT4 phosphatase-associated protein FCP1_C PF09309.5 CDI79642.1 - 0.18 11.0 0.1 0.18 11.0 0.1 6.7 5 2 3 8 8 8 0 FCP1, C-terminal LMBR1 PF04791.11 CDI79642.1 - 0.56 8.7 8.8 0.95 7.9 6.1 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Mem_trans PF03547.13 CDI79642.1 - 7.4 4.7 6.2 16 3.6 4.3 1.6 1 0 0 1 1 1 0 Membrane transport protein ORC3_N PF07034.6 CDI79643.1 - 9.2e-12 44.5 0.5 5.4e-10 38.7 0.2 4.8 6 0 0 6 6 6 2 Origin recognition complex (ORC) subunit 3 N-terminus EGF_CA PF07645.10 CDI79644.1 - 6.7e-28 96.4 72.9 1.1e-10 41.3 5.5 5.7 5 0 0 5 5 5 4 Calcium-binding EGF domain cEGF PF12662.2 CDI79644.1 - 1.3e-14 53.4 33.6 0.0003 20.3 0.2 6.4 5 1 0 5 5 5 5 Complement Clr-like EGF-like EGF_3 PF12947.2 CDI79644.1 - 2.7e-13 49.6 70.6 3.3e-06 26.9 6.7 5.9 6 0 0 6 6 6 5 EGF domain EGF PF00008.22 CDI79644.1 - 1.4e-07 31.3 61.7 0.018 14.9 4.6 6.4 6 0 0 6 6 6 5 EGF-like domain EGF_MSP1_1 PF12946.2 CDI79644.1 - 0.014 15.1 8.3 0.014 15.1 5.8 5.0 5 0 0 5 5 5 0 MSP1 EGF domain 1 FXa_inhibition PF14670.1 CDI79644.1 - 0.018 15.1 66.0 0.092 12.8 5.9 5.8 5 0 0 5 5 5 0 Coagulation Factor Xa inhibitory site DUF2255 PF10012.4 CDI79644.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) GP41 PF00517.12 CDI79644.1 - 0.32 10.5 0.1 0.32 10.5 0.0 1.8 2 0 0 2 2 2 0 Retroviral envelope protein hEGF PF12661.2 CDI79644.1 - 3.2 8.0 19.7 1.8 8.7 0.3 5.7 4 0 0 4 4 4 0 Human growth factor-like EGF 14-3-3 PF00244.15 CDI79645.1 - 1.7e-108 361.1 9.8 2e-108 360.9 6.8 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF4085 PF13315.1 CDI79645.1 - 0.53 9.6 5.2 0.1 11.9 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4085) DUF3693 PF12472.3 CDI79647.1 - 0.05 13.2 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Phage related protein DUF2325 PF10087.4 CDI79648.1 - 0.13 12.1 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) Prefoldin PF02996.12 CDI79649.1 - 6.2e-21 74.2 4.7 9.4e-21 73.6 3.3 1.3 1 0 0 1 1 1 1 Prefoldin subunit Nsp1_C PF05064.8 CDI79649.1 - 0.037 13.6 1.1 0.037 13.6 0.8 2.1 2 0 0 2 2 2 0 Nsp1-like C-terminal region TMPIT PF07851.8 CDI79649.1 - 0.3 10.1 4.2 0.26 10.3 0.1 2.0 2 0 0 2 2 2 0 TMPIT-like protein V_ATPase_I PF01496.14 CDI79649.1 - 0.51 8.1 2.9 0.89 7.3 2.0 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Cut12 PF11500.3 CDI79649.1 - 1.1 8.9 8.2 0.26 10.9 0.1 2.1 2 0 0 2 2 2 0 Spindle pole body formation-associated protein Dict-STAT-coil PF09267.5 CDI79649.1 - 1.3 9.3 6.1 3.7 7.8 1.1 2.4 2 0 0 2 2 2 0 Dictyostelium STAT, coiled coil TFIID_30kDa PF03540.8 CDI79650.1 - 0.00014 21.5 0.2 0.00048 19.9 0.0 2.0 2 0 0 2 2 2 1 Transcription initiation factor TFIID 23-30kDa subunit zf-A20 PF01754.11 CDI79652.1 - 7e-11 41.4 6.2 7e-11 41.4 4.3 1.9 2 0 0 2 2 2 1 A20-like zinc finger Mpv17_PMP22 PF04117.7 CDI79653.1 - 0.0016 18.0 0.2 0.0045 16.5 0.0 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family Dehydrin PF00257.14 CDI79653.1 - 0.0054 17.0 10.6 0.11 12.8 0.2 2.7 2 0 0 2 2 2 2 Dehydrin Suf PF05843.9 CDI79653.1 - 0.059 13.1 12.4 0.15 11.7 2.3 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SelP_N PF04592.9 CDI79653.1 - 3.2 7.0 20.5 1.1 8.5 3.3 2.3 2 0 0 2 2 2 0 Selenoprotein P, N terminal region CD20 PF04103.10 CDI79653.1 - 4.4 7.2 10.1 0.48 10.3 0.1 3.1 2 1 0 2 2 2 0 CD20-like family Zip PF02535.17 CDI79653.1 - 6.1 5.7 21.4 4.5 6.2 2.9 2.4 1 1 1 2 2 2 0 ZIP Zinc transporter PXA PF02194.10 CDI79653.1 - 6.9 6.1 11.7 9.2 5.7 0.6 2.3 2 0 0 2 2 2 0 PXA domain LCCL PF03815.14 CDI79654.1 - 9e-20 70.4 0.3 9e-20 70.4 0.2 2.9 2 1 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.20 CDI79654.1 - 2.8e-13 49.8 0.0 2.8e-13 49.8 0.0 3.1 3 0 0 3 3 3 2 F5/8 type C domain Fibrinogen_C PF00147.13 CDI79654.1 - 0.016 14.8 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain TMF_TATA_bd PF12325.3 CDI79654.1 - 4.1 7.1 5.1 7 6.4 0.3 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Histone PF00125.19 CDI79655.1 - 1.5e-20 73.0 0.4 2.2e-20 72.5 0.3 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDI79655.1 - 0.00012 22.0 0.6 0.00018 21.4 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 CDI79655.1 - 0.00068 19.8 0.0 0.001 19.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Asr PF06392.6 CDI79655.1 - 0.27 11.6 5.8 0.54 10.6 4.0 1.5 1 0 0 1 1 1 0 Acid shock protein repeat ATG_C PF09333.6 CDI79657.1 - 6e-09 35.9 0.1 3.7e-08 33.4 0.0 2.3 2 0 0 2 2 2 1 ATG C terminal domain PITH PF06201.8 CDI79659.1 - 5.6e-17 61.9 0.0 1.2e-16 60.7 0.0 1.5 1 1 0 1 1 1 1 PITH domain Sad1_UNC PF07738.8 CDI79659.1 - 0.071 12.9 0.0 0.27 11.0 0.0 2.0 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal DEAD PF00270.24 CDI79661.1 - 5.5e-16 58.5 0.1 8.5e-16 57.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CDI79661.1 - 0.019 14.7 0.7 0.044 13.5 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit CDK2AP PF09806.4 CDI79662.1 - 0.01 16.1 26.0 0.043 14.0 8.5 2.5 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein BAF1_ABF1 PF04684.8 CDI79662.1 - 0.42 9.3 21.6 0.018 13.8 9.9 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor EcsC PF12787.2 CDI79662.1 - 0.79 9.0 6.9 0.088 12.1 1.4 1.8 3 0 0 3 3 3 0 EcsC protein family FAM176 PF14851.1 CDI79662.1 - 0.99 9.0 7.1 0.23 11.1 1.8 1.9 2 0 0 2 2 2 0 FAM176 family Orbi_VP6 PF01516.11 CDI79662.1 - 1 8.3 6.1 1.9 7.4 4.2 1.3 1 0 0 1 1 1 0 Orbivirus helicase VP6 Med15 PF09606.5 CDI79662.1 - 1.3 7.1 30.4 2 6.4 21.1 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal APC_CDC26 PF10471.4 CDI79662.1 - 1.4 9.6 36.1 6 7.6 14.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Pap_E4 PF02711.9 CDI79662.1 - 1.8 9.4 11.4 1.3 9.9 1.8 2.5 2 0 0 2 2 2 0 E4 protein Suf PF05843.9 CDI79662.1 - 1.9 8.1 10.7 2.9 7.5 7.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Na_trans_assoc PF06512.8 CDI79662.1 - 6.9 6.5 10.3 3.4 7.5 1.9 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated DUF572 PF04502.8 CDI79662.1 - 8 5.5 16.3 12 5.0 11.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DEAD PF00270.24 CDI79663.1 - 1.4e-17 63.7 51.8 2.6e-17 62.8 17.0 4.7 4 1 1 5 5 5 3 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79663.1 - 4e-14 52.2 0.0 4e-14 52.2 0.0 3.5 5 0 0 5 5 5 1 Helicase conserved C-terminal domain Ctr PF04145.10 CDI79663.1 - 0.019 14.9 0.9 0.019 14.9 0.6 6.5 3 2 0 4 4 4 0 Ctr copper transporter family Phage_integrase PF00589.17 CDI79665.1 - 9.7e-12 44.8 0.0 2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family SAP PF02037.22 CDI79665.1 - 3.4e-05 23.2 0.4 0.00011 21.6 0.3 1.9 1 0 0 1 1 1 1 SAP domain DZR PF12773.2 CDI79665.1 - 0.00027 20.7 1.0 0.00068 19.4 0.7 1.6 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 CDI79665.1 - 0.00033 19.7 1.8 0.00075 18.6 1.2 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CDI79665.1 - 0.00046 19.5 0.6 0.0011 18.4 0.4 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-DHHC PF01529.15 CDI79665.1 - 0.063 12.6 0.0 0.099 12.0 0.0 1.5 1 0 0 1 1 1 0 DHHC palmitoyltransferase PLATZ PF04640.9 CDI79665.1 - 0.091 12.9 0.3 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 PLATZ transcription factor TFIIA PF03153.8 CDI79665.1 - 1.5 8.6 4.4 2 8.2 3.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DEAD PF00270.24 CDI79666.1 - 2.6e-31 108.3 0.8 5e-31 107.4 0.3 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79666.1 - 4.2e-16 58.5 0.0 1.4e-11 44.0 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDI79666.1 - 0.006 16.7 0.1 0.028 14.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain ResIII PF04851.10 CDI79666.1 - 0.012 15.4 0.0 0.039 13.7 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Auxin_repressed PF05564.7 CDI79666.1 - 5.6 7.5 7.4 0.73 10.4 1.6 2.1 2 0 0 2 2 2 0 Dormancy/auxin associated protein Surface_antigen PF11054.3 CDI79668.1 - 5.4e-53 179.9 0.4 8.1e-53 179.4 0.3 1.1 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI79669.1 - 5.1e-69 232.4 2.4 5.7e-69 232.3 1.7 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI79670.1 - 4e-68 229.5 4.7 5e-68 229.2 3.3 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI79671.1 - 9.5e-67 225.0 0.0 1.1e-66 224.8 0.0 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI79672.1 - 3.2e-68 229.8 3.4 3.7e-68 229.6 2.3 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen GCD14 PF08704.5 CDI79673.1 - 4e-65 219.7 0.0 2.7e-41 141.7 0.0 2.4 2 1 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 CDI79673.1 - 8.1e-07 28.7 0.0 1.4e-05 24.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI79673.1 - 9.5e-06 26.1 0.0 1.8e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI79673.1 - 4.1e-05 23.6 0.1 0.00035 20.5 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 CDI79673.1 - 0.00061 19.3 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 CDI79673.1 - 0.017 14.4 0.0 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain RrnaAD PF00398.15 CDI79673.1 - 0.091 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Surface_antigen PF11054.3 CDI79674.1 - 1.1e-57 195.3 0.0 1.2e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen ABC_tran PF00005.22 CDI79675.1 - 4.6e-33 114.4 0.0 8.4e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 CDI79675.1 - 4.4e-18 65.6 6.8 6.8e-18 65.0 4.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.1 CDI79675.1 - 2.8e-07 30.8 0.0 0.0057 16.6 0.0 2.2 1 1 0 2 2 2 2 AAA domain SMC_N PF02463.14 CDI79675.1 - 3.9e-05 22.9 0.0 0.00097 18.4 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CDI79675.1 - 0.00026 21.0 0.1 0.00026 21.0 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 CDI79675.1 - 0.0012 18.9 1.0 0.054 13.6 0.0 3.4 4 0 0 4 4 4 1 AAA domain Zeta_toxin PF06414.7 CDI79675.1 - 0.0022 17.1 0.0 0.0044 16.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin MobB PF03205.9 CDI79675.1 - 0.0029 17.3 0.0 0.014 15.1 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 CDI79675.1 - 0.0036 16.8 0.0 0.01 15.3 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 CDI79675.1 - 0.018 15.3 0.0 0.052 13.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA PF00004.24 CDI79675.1 - 0.025 14.7 0.0 0.31 11.2 0.0 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDI79675.1 - 0.027 15.2 0.0 0.056 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CDI79675.1 - 0.034 13.7 0.0 0.1 12.2 0.0 1.9 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.8 CDI79675.1 - 0.041 12.8 0.0 0.07 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.1 CDI79675.1 - 0.051 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDI79675.1 - 0.055 12.6 0.0 0.14 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Miro PF08477.8 CDI79675.1 - 0.067 13.6 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein Pox_A32 PF04665.7 CDI79675.1 - 0.18 11.1 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein TMEM52 PF14979.1 CDI79676.1 - 0.063 13.1 2.1 0.058 13.3 0.8 1.4 1 1 1 2 2 2 0 Transmembrane 52 DUF1290 PF06947.7 CDI79676.1 - 0.099 12.5 0.2 0.12 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1290) L51_S25_CI-B8 PF05047.11 CDI79677.1 - 0.00012 21.7 0.0 0.00024 20.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Pkinase PF00069.20 CDI79679.1 - 1.6e-68 230.6 0.0 2.2e-68 230.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79679.1 - 1.8e-29 102.5 0.0 2.8e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI79679.1 - 0.013 14.4 0.0 0.061 12.2 0.0 2.0 2 1 1 3 3 3 0 Kinase-like APH PF01636.18 CDI79679.1 - 0.051 13.3 0.0 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Hex_IIIa PF02455.11 CDI79679.1 - 0.68 8.5 5.1 1 7.9 3.6 1.2 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF4551 PF15087.1 CDI79679.1 - 10 4.3 10.9 16 3.6 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TTL PF03133.10 CDI79681.1 - 2.3e-49 167.9 0.1 2.3e-49 167.9 0.1 4.2 4 0 0 4 4 4 1 Tubulin-tyrosine ligase family EF-hand_4 PF12763.2 CDI79682.1 - 5.7e-09 35.6 0.0 9.7e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand PDDEXK_1 PF12705.2 CDI79683.1 - 0.073 12.4 0.1 0.092 12.1 0.1 1.1 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Dehydrin PF00257.14 CDI79684.1 - 0.031 14.5 1.3 0.031 14.5 0.9 1.8 2 0 0 2 2 2 0 Dehydrin APC_CDC26 PF10471.4 CDI79684.1 - 0.041 14.6 5.8 0.041 14.6 4.0 3.8 5 0 0 5 5 5 0 Anaphase-promoting complex APC subunit 1 Pol_alpha_B_N PF08418.5 CDI79684.1 - 1.1 8.7 5.3 2.3 7.6 3.7 1.6 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DLIC PF05783.6 CDI79684.1 - 3.9 6.0 20.2 1.6 7.3 4.6 2.1 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) PAT1 PF09770.4 CDI79684.1 - 4.9 5.2 18.8 6.2 4.9 13.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF755 PF05501.6 CDI79685.1 - 0.013 15.5 5.5 0.013 15.5 3.8 6.9 6 1 0 6 6 6 0 Domain of unknown function (DUF755) Mem_trans PF03547.13 CDI79685.1 - 1.4 7.1 12.6 0.96 7.6 3.7 2.4 2 0 0 2 2 2 0 Membrane transport protein DUF572 PF04502.8 CDI79685.1 - 8.3 5.5 49.5 1.4 8.0 18.4 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF572) Bromodomain PF00439.20 CDI79687.1 - 1.8e-15 56.5 0.0 2.9e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain MIF4G PF02854.14 CDI79688.1 - 1e-27 96.9 2.4 2.1e-27 95.9 1.6 1.5 1 0 0 1 1 1 1 MIF4G domain PrgI PF12666.2 CDI79689.1 - 0.021 14.9 1.1 0.021 14.9 0.8 2.2 1 1 1 2 2 2 0 PrgI family protein DUF2938 PF11158.3 CDI79689.1 - 0.17 11.2 2.7 0.79 9.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2938) DUF986 PF06173.7 CDI79689.1 - 0.21 11.4 2.5 0.36 10.6 1.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF986) DUF515 PF04415.7 CDI79689.1 - 3.7 5.6 9.0 5.3 5.1 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Keratin_assoc PF09775.4 CDI79689.1 - 7.8 6.0 9.7 0.49 9.9 3.1 1.6 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 Med15 PF09606.5 CDI79690.1 - 5.9e-08 31.4 31.7 8.6e-08 30.8 22.0 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 CDI79690.1 - 0.0032 17.4 22.7 0.0075 16.2 15.7 1.7 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit AAA_11 PF13086.1 CDI79690.1 - 0.017 14.7 14.8 0.035 13.6 10.2 1.5 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.4 CDI79690.1 - 0.097 10.8 35.2 0.15 10.3 24.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Borrelia_P83 PF05262.6 CDI79690.1 - 0.64 8.2 28.3 1 7.5 19.6 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein LMBR1 PF04791.11 CDI79690.1 - 3.6 6.0 8.3 6.9 5.1 5.7 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Ndc1_Nup PF09531.5 CDI79690.1 - 4.7 5.5 14.7 7.7 4.8 10.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mem_trans PF03547.13 CDI79690.1 - 7.7 4.6 6.8 14 3.8 4.7 1.4 1 0 0 1 1 1 0 Membrane transport protein Ycf1 PF05758.7 CDI79690.1 - 9 3.8 23.0 13 3.3 15.9 1.1 1 0 0 1 1 1 0 Ycf1 HMG_box PF00505.14 CDI79692.1 - 8.9e-06 25.8 5.9 0.00018 21.7 0.1 3.0 3 0 0 3 3 3 2 HMG (high mobility group) box Myb_DNA-binding PF00249.26 CDI79692.1 - 0.0053 16.7 0.2 0.014 15.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PA PF02225.17 CDI79694.1 - 1.1e-08 34.7 0.0 2.3e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 PA domain Tim54 PF11711.3 CDI79694.1 - 0.16 10.5 0.0 0.29 9.6 0.0 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sigma_reg_N PF13800.1 CDI79694.1 - 0.18 11.8 0.1 0.41 10.7 0.1 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal WD40 PF00400.27 CDI79695.1 - 2.2e-51 170.0 31.9 1.9e-12 46.5 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat PQQ_3 PF13570.1 CDI79695.1 - 8.5e-05 22.7 0.6 0.006 16.8 0.0 3.5 3 1 0 3 3 3 1 PQQ-like domain Nup160 PF11715.3 CDI79695.1 - 0.066 11.3 14.0 0.88 7.6 0.3 4.3 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Citrate_synt PF00285.16 CDI79696.1 - 1.6e-90 303.3 0.0 1.9e-90 303.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase tRNA-synt_1 PF00133.17 CDI79698.1 - 9.5e-68 228.6 0.0 2.4e-45 154.6 0.0 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CDI79698.1 - 1.1e-18 67.4 0.0 1.9e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CDI79698.1 - 3.8e-08 32.4 0.0 5.6e-07 28.5 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (M) Herpes_UL20 PF04544.7 CDI79698.1 - 0.24 11.2 0.1 0.66 9.7 0.0 1.8 1 1 0 1 1 1 0 Herpesvirus egress protein UL20 DUF2012 PF09430.5 CDI79699.1 - 6e-10 39.0 0.0 8.5e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) OTU PF02338.14 CDI79700.1 - 1.7e-12 47.9 0.0 3.7e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 CDI79700.1 - 0.00061 19.2 0.1 0.0037 16.6 0.1 1.9 1 1 1 2 2 2 1 Peptidase C65 Otubain VWA PF00092.23 CDI79701.1 - 1e-36 126.2 0.0 1.4e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain TSP_1 PF00090.14 CDI79701.1 - 4.7e-21 74.6 68.4 1.9e-09 37.4 2.4 7.3 6 2 0 6 6 6 5 Thrombospondin type 1 domain VWA_2 PF13519.1 CDI79701.1 - 9.6e-15 55.1 0.0 1.5e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 CDI79701.1 - 2.9e-05 23.7 0.0 4.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 CDI79701.1 - 0.028 14.2 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 vWA found in TerF C terminus NRN1 PF15056.1 CDI79701.1 - 0.12 12.3 2.8 2.9 7.9 0.1 2.6 2 0 0 2 2 2 0 Neuritin protein family DUF3689 PF12463.3 CDI79703.1 - 1.5e-27 96.1 1.9 1.2e-09 37.3 0.1 4.1 3 0 0 3 3 3 3 Protein of unknown function (DUF3689) SR-25 PF10500.4 CDI79703.1 - 2.7e-06 27.0 15.4 2.7e-06 27.0 10.6 22.8 17 6 2 21 21 21 3 Nuclear RNA-splicing-associated protein RRM_1 PF00076.17 CDI79704.1 - 2.2e-21 75.2 0.0 9.1e-10 38.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79704.1 - 2.7e-18 65.7 0.0 1.4e-08 34.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI79704.1 - 1.5e-10 40.7 0.3 0.00027 20.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_transf_21 PF13506.1 CDI79704.1 - 0.083 12.1 0.1 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 Borrelia_P83 PF05262.6 CDI79704.1 - 0.24 9.6 8.4 0.31 9.2 5.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Dehydrin PF00257.14 CDI79704.1 - 0.25 11.6 18.8 0.41 10.9 13.1 1.4 1 0 0 1 1 1 0 Dehydrin Raftlin PF15250.1 CDI79704.1 - 0.5 8.8 11.7 0.65 8.4 8.1 1.1 1 0 0 1 1 1 0 Raftlin Ycf1 PF05758.7 CDI79704.1 - 0.65 7.6 6.1 0.72 7.5 4.3 1.2 1 0 0 1 1 1 0 Ycf1 Hid1 PF12722.2 CDI79704.1 - 0.78 7.3 8.4 0.91 7.1 5.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.17 CDI79704.1 - 0.89 8.5 6.6 1.1 8.1 4.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1510 PF07423.6 CDI79704.1 - 1.1 8.5 14.5 1.7 7.9 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Presenilin PF01080.12 CDI79704.1 - 1.4 7.6 5.6 2.3 6.9 3.9 1.3 1 0 0 1 1 1 0 Presenilin DUF4557 PF15101.1 CDI79704.1 - 2.1 8.1 12.7 4.1 7.2 8.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) NPR3 PF03666.8 CDI79704.1 - 2.5 6.5 10.1 3.9 5.8 7.0 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spore_coat_CotO PF14153.1 CDI79704.1 - 2.5 7.4 15.5 5.3 6.4 10.7 1.5 1 0 0 1 1 1 0 Spore coat protein CotO Neur_chan_memb PF02932.11 CDI79704.1 - 2.8 7.7 8.3 4.3 7.1 5.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.9 CDI79704.1 - 3.3 5.6 12.7 1.2 7.0 7.1 1.4 2 0 0 2 2 2 0 CDC45-like protein Ribosomal_60s PF00428.14 CDI79704.1 - 6.1 7.3 10.6 0.59 10.5 0.4 2.7 3 0 0 3 3 2 0 60s Acidic ribosomal protein RIC3 PF15361.1 CDI79705.1 - 0.034 14.3 0.8 0.034 14.3 0.5 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DBC1 PF14443.1 CDI79705.1 - 0.15 11.5 3.7 0.28 10.7 2.6 1.4 1 0 0 1 1 1 0 DBC1 SHR3_chaperone PF08229.6 CDI79705.1 - 1.6 7.6 6.6 2.4 7.0 4.6 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 DUF788 PF05620.6 CDI79705.1 - 2.5 7.9 7.3 4.8 7.0 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF788) DivIC PF04977.10 CDI79705.1 - 3.3 7.2 17.1 4.6 6.7 11.8 1.2 1 0 0 1 1 1 0 Septum formation initiator RskA PF10099.4 CDI79705.1 - 3.9 7.1 14.3 6 6.5 3.2 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF4199 PF13858.1 CDI79705.1 - 6.5 6.6 5.1 12 5.8 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) RNase_Zc3h12a PF11977.3 CDI79707.1 - 2.3e-14 53.5 11.2 1.8e-09 37.6 0.0 3.4 2 2 1 3 3 3 2 Zc3h12a-like Ribonuclease NYN domain Ribosomal_60s PF00428.14 CDI79707.1 - 0.4 11.1 13.6 4.8 7.6 0.5 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Response_reg PF00072.19 CDI79708.1 - 0.027 14.4 0.0 4.9 7.1 0.1 2.3 2 0 0 2 2 2 0 Response regulator receiver domain Secretin_N_2 PF07655.8 CDI79708.1 - 0.029 14.7 15.7 0.071 13.4 10.9 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Macoilin PF09726.4 CDI79708.1 - 0.33 9.1 8.1 0.39 8.9 5.6 1.1 1 0 0 1 1 1 0 Transmembrane protein TFIIA PF03153.8 CDI79708.1 - 0.61 9.9 4.1 0.76 9.6 2.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.8 CDI79708.1 - 0.69 9.9 7.6 1.2 9.1 5.2 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0051 PF01458.12 CDI79712.1 - 1.6e-44 152.1 0.0 8.6e-44 149.6 0.0 2.1 1 1 0 1 1 1 1 Uncharacterized protein family (UPF0051) Sporozoite_P67 PF05642.6 CDI79713.1 - 0.00036 18.5 22.1 0.00036 18.5 15.3 2.3 2 0 0 2 2 2 2 Sporozoite P67 surface antigen LMBR1 PF04791.11 CDI79713.1 - 1 7.8 1.6 20 3.5 3.0 1.7 2 0 0 2 2 2 0 LMBR1-like membrane protein Peptidase_S8 PF00082.17 CDI79714.1 - 1.7e-42 145.5 8.3 4.3e-42 144.1 5.8 1.7 1 0 0 1 1 1 1 Subtilase family LMBR1 PF04791.11 CDI79715.1 - 0.052 12.1 0.4 0.14 10.6 0.3 1.8 1 1 0 1 1 1 0 LMBR1-like membrane protein CDK2AP PF09806.4 CDI79715.1 - 2.1 8.5 9.3 0.48 10.6 1.5 2.6 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Sec20 PF03908.8 CDI79716.1 - 0.00014 21.4 7.8 0.11 12.1 0.3 2.9 2 0 0 2 2 2 2 Sec20 FliD_C PF07195.7 CDI79716.1 - 3.6 6.8 7.2 0.22 10.7 0.2 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus ABC_tran PF00005.22 CDI79717.1 - 1.3e-23 83.8 0.1 2e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 CDI79717.1 - 4.3e-12 45.6 3.2 2.6e-09 36.5 2.5 2.7 2 1 0 2 2 2 1 ABC-2 type transporter AAA_21 PF13304.1 CDI79717.1 - 1.1e-08 35.4 0.3 4.7e-06 26.7 0.2 2.3 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CDI79717.1 - 6.7e-05 22.1 0.1 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 CDI79717.1 - 0.00012 22.1 0.2 0.0003 20.8 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 CDI79717.1 - 0.00022 20.6 0.3 0.00055 19.4 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 CDI79717.1 - 0.00094 18.6 0.1 0.0024 17.3 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDI79717.1 - 0.004 17.4 0.0 0.01 16.1 0.0 1.7 2 0 0 2 2 1 1 AAA domain MMR_HSR1 PF01926.18 CDI79717.1 - 0.0083 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF87 PF01935.12 CDI79717.1 - 0.011 15.5 0.6 0.02 14.6 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_17 PF13207.1 CDI79717.1 - 0.012 16.3 0.0 0.026 15.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 CDI79717.1 - 0.038 12.7 0.2 0.079 11.7 0.1 1.4 1 0 0 1 1 1 0 ArgK protein AAA_28 PF13521.1 CDI79717.1 - 0.052 13.5 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 CDI79717.1 - 0.099 12.2 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CDI79717.1 - 0.1 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.1 CDI79717.1 - 0.11 12.6 0.1 0.41 10.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CDI79717.1 - 0.14 11.5 0.5 0.26 10.6 0.3 1.3 1 0 0 1 1 1 0 AAA-like domain UPF0079 PF02367.12 CDI79717.1 - 0.15 11.7 0.3 0.31 10.6 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_15 PF13175.1 CDI79717.1 - 0.36 9.8 0.0 0.56 9.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DEAD PF00270.24 CDI79719.1 - 7.4e-31 106.9 0.0 3.5e-22 78.6 0.0 2.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI79719.1 - 3.1e-23 81.4 0.0 5.8e-23 80.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI79719.1 - 0.00018 21.4 0.0 0.00075 19.3 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit MutS_III PF05192.13 CDI79719.1 - 0.044 13.5 1.0 0.086 12.6 0.7 1.5 1 1 0 1 1 1 0 MutS domain III Peptidase_M41 PF01434.13 CDI79720.1 - 1.6e-44 151.9 1.0 9.9e-38 129.7 0.0 3.1 3 0 0 3 3 3 2 Peptidase family M41 AAA PF00004.24 CDI79720.1 - 9.5e-42 142.3 0.0 2.3e-41 141.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDI79720.1 - 1.5e-05 25.7 0.0 5.2e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 CDI79720.1 - 0.0003 19.6 0.0 0.00055 18.7 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 CDI79720.1 - 0.00049 20.2 0.7 0.031 14.4 0.1 3.0 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.9 CDI79720.1 - 0.00087 19.0 0.2 0.0055 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CDI79720.1 - 0.0011 18.6 0.4 0.011 15.5 0.2 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_16 PF13191.1 CDI79720.1 - 0.0023 17.9 0.1 0.0023 17.9 0.1 3.4 3 1 0 3 3 3 1 AAA ATPase domain Zeta_toxin PF06414.7 CDI79720.1 - 0.0029 16.7 0.1 0.023 13.7 0.0 2.3 1 1 1 2 2 2 1 Zeta toxin RuvB_N PF05496.7 CDI79720.1 - 0.0075 15.3 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CDI79720.1 - 0.0085 15.9 0.0 0.03 14.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CDI79720.1 - 0.009 15.4 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 CDI79720.1 - 0.035 14.4 0.0 0.095 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 CDI79720.1 - 0.097 12.5 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CDI79720.1 - 0.12 12.3 0.0 0.12 12.3 0.0 2.6 3 1 0 3 3 2 0 AAA domain AAA_25 PF13481.1 CDI79720.1 - 0.24 10.7 5.8 0.19 11.0 0.5 2.8 2 1 1 3 3 3 0 AAA domain Mg_chelatase PF01078.16 CDI79720.1 - 0.46 9.6 4.1 0.1 11.7 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Shisa PF13908.1 CDI79720.1 - 9 6.4 8.4 18 5.4 5.8 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2217 PF10265.4 CDI79724.1 - 0.8 8.3 5.2 1.1 7.9 3.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) U79_P34 PF03064.11 CDI79724.1 - 1.1 8.7 9.3 0.095 12.2 3.3 1.5 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Hid1 PF12722.2 CDI79724.1 - 4.7 4.7 6.8 5.3 4.5 4.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.1 CDI79724.1 - 5.2 6.7 9.0 8.2 6.1 6.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Macro PF01661.16 CDI79725.1 - 0.00035 20.4 0.0 0.0011 18.8 0.0 2.0 1 1 1 2 2 2 1 Macro domain DUF429 PF04250.8 CDI79725.1 - 0.15 11.3 2.7 2.6 7.2 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF429) BRF1 PF07741.8 CDI79725.1 - 4.7 7.5 8.5 6.7 7.0 0.2 2.8 3 0 0 3 3 3 0 Brf1-like TBP-binding domain Nop16 PF09420.5 CDI79726.1 - 2e-11 44.2 0.4 2e-11 44.2 0.3 1.9 2 1 0 2 2 2 1 Ribosome biogenesis protein Nop16 Myb_DNA-bind_4 PF13837.1 CDI79726.1 - 0.0049 16.9 0.2 0.0098 16.0 0.1 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF2201_N PF13203.1 CDI79726.1 - 0.91 8.6 12.1 1.1 8.3 8.4 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain CobT PF06213.7 CDI79726.1 - 1.9 7.5 10.3 2 7.4 7.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.9 CDI79726.1 - 3.4 5.6 15.9 3.8 5.4 11.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1675 PF07897.6 CDI79726.1 - 3.4 7.4 23.5 3.6 7.3 16.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DDHD PF02862.12 CDI79726.1 - 5.1 6.8 19.7 6.6 6.4 13.6 1.3 1 0 0 1 1 1 0 DDHD domain GPCR_chapero_1 PF11904.3 CDI79726.1 - 7.1 5.6 13.9 8 5.5 9.7 1.1 1 0 0 1 1 1 0 GPCR-chaperone DUF605 PF04652.11 CDI79726.1 - 7.4 5.8 20.8 7.4 5.8 14.4 1.1 1 0 0 1 1 1 0 Vta1 like SRP-alpha_N PF04086.8 CDI79726.1 - 9.6 5.4 19.9 9.8 5.4 13.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RRM_1 PF00076.17 CDI79727.1 - 4.7e-37 125.4 0.8 1.8e-17 62.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79727.1 - 9.5e-28 95.9 0.2 5.8e-13 48.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI79727.1 - 1.1e-08 34.8 0.0 0.0034 17.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDI79727.1 - 0.00016 21.3 0.0 0.029 14.1 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 CDI79727.1 - 0.002 17.9 5.1 0.24 11.2 0.0 3.4 2 1 0 3 3 2 2 RNA binding motif RAB3GAP2_N PF14655.1 CDI79727.1 - 0.0029 16.6 2.7 0.0046 16.0 1.9 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus OB_RNB PF08206.6 CDI79727.1 - 0.11 12.0 0.1 3.2 7.3 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Sec62 PF03839.11 CDI79727.1 - 0.14 11.5 0.9 0.27 10.5 0.6 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Ycf1 PF05758.7 CDI79727.1 - 0.3 8.7 3.0 0.33 8.6 2.1 1.1 1 0 0 1 1 1 0 Ycf1 Hid1 PF12722.2 CDI79727.1 - 0.5 7.9 3.0 0.55 7.8 2.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spt20 PF12090.3 CDI79727.1 - 0.99 8.7 8.0 0.022 14.1 1.1 1.6 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.12 CDI79727.1 - 2.2 7.0 4.0 3.4 6.3 2.8 1.2 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.1 CDI79727.1 - 4.9 7.3 7.8 4.6 7.4 3.8 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Serinc PF03348.10 CDI79727.1 - 6.6 5.3 4.5 8.3 4.9 3.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DDHD PF02862.12 CDI79727.1 - 9.4 5.9 8.8 2.9 7.6 4.2 1.5 2 0 0 2 2 2 0 DDHD domain DHHW PF14286.1 CDI79730.1 - 1.6 7.9 6.1 1.8 7.8 1.2 2.1 2 0 0 2 2 2 0 DHHW protein GCD14 PF08704.5 CDI79730.1 - 1.7 8.1 5.6 5.7 6.3 0.1 2.1 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit MAS20 PF02064.10 CDI79730.1 - 2.1 8.3 9.0 1.8 8.5 1.3 2.4 2 0 0 2 2 2 0 MAS20 protein import receptor eIF3g PF12353.3 CDI79730.1 - 9.2 6.1 9.5 0.44 10.4 1.8 2.2 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Pkinase PF00069.20 CDI79731.1 - 4.9e-28 97.9 0.0 7.1e-28 97.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79731.1 - 2.1e-11 43.3 0.0 2.9e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI79731.1 - 1.6e-05 24.7 12.0 0.00075 19.2 0.1 3.7 3 1 1 4 4 4 2 Phosphotransferase enzyme family Kdo PF06293.9 CDI79731.1 - 0.019 14.0 0.1 0.05 12.6 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_11 PF13414.1 CDI79732.1 - 1.3e-76 252.1 30.3 6.2e-19 67.4 0.1 6.2 6 0 0 6 6 6 6 TPR repeat TPR_1 PF00515.23 CDI79732.1 - 7.6e-62 202.5 33.3 1e-08 34.4 0.0 9.3 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.12 CDI79732.1 - 3e-53 173.4 28.5 2.3e-06 27.0 0.0 9.3 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_12 PF13424.1 CDI79732.1 - 1.4e-33 114.6 11.2 9.7e-14 51.0 1.1 5.9 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 CDI79732.1 - 5.4e-30 103.3 9.8 4.9e-05 23.8 0.0 6.4 4 2 2 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.1 CDI79732.1 - 5.6e-30 100.8 23.2 0.0011 18.5 0.0 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.1 CDI79732.1 - 1.5e-25 87.3 6.3 0.00078 19.8 0.1 9.5 4 3 5 9 9 9 6 Tetratricopeptide repeat TPR_17 PF13431.1 CDI79732.1 - 4.9e-24 82.4 16.1 0.0027 17.7 0.0 9.1 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_9 PF13371.1 CDI79732.1 - 9.8e-19 66.9 3.4 4.6e-05 23.1 0.0 7.2 2 2 6 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDI79732.1 - 1e-18 67.4 13.5 0.0025 18.1 0.0 6.7 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.1 CDI79732.1 - 1.3e-16 58.9 10.4 0.00043 19.8 0.1 8.6 9 0 0 9 9 8 3 Tetratricopeptide repeat Apc3 PF12895.2 CDI79732.1 - 1e-10 41.5 17.6 0.0023 18.0 5.6 5.2 3 3 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 CDI79732.1 - 2e-09 37.0 7.6 0.057 13.3 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDI79732.1 - 2.2e-07 30.6 16.7 0.71 9.7 0.0 7.5 6 1 1 7 7 7 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 CDI79732.1 - 2.8e-06 27.4 15.9 5.1 7.7 0.2 8.2 8 0 0 8 8 8 1 Tetratricopeptide repeat DUF3856 PF12968.2 CDI79732.1 - 0.0031 17.3 10.0 3 7.6 0.2 4.6 3 2 0 3 3 3 2 Domain of Unknown Function (DUF3856) NARP1 PF12569.3 CDI79732.1 - 0.0036 16.1 0.3 0.0036 16.1 0.2 4.4 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 ChAPs PF09295.5 CDI79732.1 - 0.0053 15.5 4.2 0.57 8.8 0.0 3.1 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) PPR PF01535.15 CDI79732.1 - 0.22 11.5 10.3 0.61 10.1 0.1 5.3 7 0 0 7 7 5 0 PPR repeat TPR_20 PF14561.1 CDI79732.1 - 0.49 10.5 9.2 2.5 8.2 0.0 4.8 5 1 1 6 6 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 CDI79732.1 - 1.1 8.5 8.5 7.9 5.8 0.0 5.5 7 0 0 7 7 7 0 SHNi-TPR DnaI_N PF07319.6 CDI79732.1 - 2.9 8.2 12.3 0.097 12.9 0.6 3.7 4 0 0 4 4 4 0 Primosomal protein DnaI N-terminus Helicase_C_2 PF13307.1 CDI79735.1 - 4.8e-37 127.4 0.3 9.2e-34 116.8 0.0 3.0 3 0 0 3 3 3 2 Helicase C-terminal domain DEAD_2 PF06733.10 CDI79735.1 - 2e-30 105.4 0.0 4.5e-30 104.3 0.0 1.6 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 CDI79735.1 - 0.018 14.5 0.6 0.081 12.4 0.0 2.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase DUF2607 PF10795.4 CDI79736.1 - 0.099 12.4 0.0 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2607) DUF2408 PF10303.4 CDI79737.1 - 0.05 13.7 3.4 0.16 12.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) Acyl-CoA_dh_2 PF08028.6 CDI79737.1 - 1.8 8.8 13.6 0.44 10.8 0.8 4.1 3 1 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain ASFV_J13L PF05568.6 CDI79741.1 - 2.4 7.6 7.0 1.5 8.3 0.7 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein Ribosomal_60s PF00428.14 CDI79741.1 - 9.1 6.7 25.3 1 9.7 4.7 2.2 1 1 1 2 2 2 0 60s Acidic ribosomal protein NOT2_3_5 PF04153.13 CDI79742.1 - 3.2e-18 65.9 0.1 3.2e-18 65.9 0.1 3.3 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family ORC5_C PF14630.1 CDI79742.1 - 0.23 10.8 3.1 0.47 9.8 2.1 1.4 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus DLIC PF05783.6 CDI79742.1 - 1.7 7.2 4.6 2.7 6.5 3.2 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DUF4647 PF15504.1 CDI79742.1 - 6.7 5.4 16.0 14 4.3 11.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) PAT1 PF09770.4 CDI79742.1 - 9.9 4.2 43.3 0.29 9.3 25.3 1.8 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Pox_Ag35 PF03286.9 CDI79743.1 - 0.023 14.2 2.8 0.058 12.9 0.6 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF2116 PF09889.4 CDI79743.1 - 0.11 12.3 0.1 0.11 12.3 0.1 3.9 4 1 0 4 4 4 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) FAM176 PF14851.1 CDI79743.1 - 0.2 11.2 4.3 1.1 8.9 0.8 2.9 3 0 0 3 3 3 0 FAM176 family DUF3357 PF11837.3 CDI79743.1 - 0.72 9.7 5.3 0.43 10.4 0.1 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3357) Ycf1 PF05758.7 CDI79743.1 - 5.5 4.5 11.2 0.73 7.4 4.7 1.8 2 1 0 2 2 2 0 Ycf1 ATP12 PF07542.6 CDI79744.1 - 2.4e-06 27.5 9.1 0.00024 21.0 6.3 2.9 1 1 0 1 1 1 1 ATP12 chaperone protein EIF4E-T PF10477.4 CDI79744.1 - 0.03 13.1 10.2 0.027 13.3 3.1 2.2 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E AAA_23 PF13476.1 CDI79744.1 - 0.059 13.6 11.6 0.079 13.2 8.0 1.2 1 0 0 1 1 1 0 AAA domain PFEMP PF03011.10 CDI79744.1 - 0.16 12.3 11.3 0.32 11.3 7.8 1.5 1 0 0 1 1 1 0 PFEMP DBL domain FimP PF09766.4 CDI79744.1 - 1 8.3 18.9 1.7 7.6 13.1 1.3 1 0 0 1 1 1 0 Fms-interacting protein Band_3_cyto PF07565.8 CDI79744.1 - 3.2 7.1 14.4 1.7 8.1 6.9 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF3886 PF13025.1 CDI79744.1 - 7.1 6.6 21.3 0.1 12.5 8.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) SOBP PF15279.1 CDI79744.1 - 7.8 6.7 14.4 12 6.1 9.5 1.7 1 1 0 1 1 1 0 Sine oculis-binding protein YTH PF04146.10 CDI79745.1 - 3.8e-11 42.7 0.3 8.4e-11 41.6 0.0 1.7 2 0 0 2 2 2 1 YT521-B-like domain Dehydrin PF00257.14 CDI79745.1 - 3.7e-05 24.1 0.7 0.00022 21.5 0.5 2.4 1 1 0 1 1 1 1 Dehydrin SRP-alpha_N PF04086.8 CDI79745.1 - 0.013 14.8 1.5 0.013 14.8 1.1 3.1 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal DUF3801 PF12687.2 CDI79745.1 - 0.033 13.7 0.2 0.033 13.7 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3801) Bul1_C PF04426.7 CDI79745.1 - 7.4 5.6 13.2 0.39 9.8 0.9 2.3 2 0 0 2 2 2 0 Bul1 C terminus DUF668 PF05003.7 CDI79750.1 - 4.4 7.5 19.7 1.9 8.7 3.4 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF668) HTH_23 PF13384.1 CDI79751.1 - 1.2e-05 24.8 1.3 4.4e-05 22.9 0.9 2.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.1 CDI79751.1 - 0.00012 21.4 1.9 0.00012 21.4 1.3 2.3 3 0 0 3 3 3 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.7 CDI79751.1 - 0.00057 19.2 0.2 0.00057 19.2 0.2 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_Tnp_Tc3_1 PF11427.3 CDI79751.1 - 0.017 14.7 1.7 0.031 13.8 1.2 1.4 1 0 0 1 1 1 0 Tc3 transposase HTH_28 PF13518.1 CDI79751.1 - 0.017 15.1 0.8 0.049 13.6 0.5 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain SR-25 PF10500.4 CDI79753.1 - 7.1e-05 22.3 29.2 7.1e-05 22.3 20.2 2.8 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein THRAP3_BCLAF1 PF15440.1 CDI79753.1 - 0.69 8.5 44.5 0.86 8.1 30.8 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family SOBP PF15279.1 CDI79753.1 - 2.7 8.3 37.3 4.3 7.6 25.8 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein TPR_MLP1_2 PF07926.7 CDI79754.1 - 3.4 7.4 13.2 0.14 11.9 4.5 1.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Syntaphilin PF15290.1 CDI79754.1 - 9.8 5.5 7.0 13 5.1 4.8 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp SNARE_assoc PF09335.6 CDI79755.1 - 1.5e-14 54.2 1.8 3.7e-07 30.3 0.0 2.3 2 1 0 2 2 2 2 SNARE associated Golgi protein SR-25 PF10500.4 CDI79755.1 - 0.0013 18.2 1.3 0.0019 17.7 0.9 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF726 PF05277.7 CDI79755.1 - 0.31 9.8 1.4 0.43 9.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF4613 PF15390.1 CDI79755.1 - 0.36 8.9 2.2 0.47 8.5 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Corona_nucleoca PF00937.13 CDI79755.1 - 0.87 8.4 6.1 1.1 8.1 4.3 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Pex14_N PF04695.8 CDI79755.1 - 1.3 9.1 6.4 0.26 11.3 1.3 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CDK2AP PF09806.4 CDI79755.1 - 1.6 8.8 9.1 0.11 12.7 0.3 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Nucleoporin_FG PF13634.1 CDI79757.1 - 1.9e-52 176.3 343.4 4.5e-13 49.4 38.2 9.5 2 2 8 10 10 10 10 Nucleoporin FG repeat region Nitro_FeMo-Co PF02579.12 CDI79757.1 - 0.0033 17.4 0.3 0.0077 16.2 0.2 1.6 1 0 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor DNA_topoisoIV PF00521.15 CDI79759.1 - 2.4e-122 408.8 0.0 3.2e-122 408.4 0.0 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 CDI79759.1 - 2.3e-28 98.5 0.5 5.4e-28 97.3 0.4 1.5 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 CDI79759.1 - 1.6e-13 50.4 0.1 8.4e-13 48.1 0.0 2.2 2 0 0 2 2 2 1 Toprim domain HATPase_c PF02518.21 CDI79759.1 - 7.7e-09 35.2 0.0 2.5e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S27 PF01599.14 CDI79760.1 - 7.4e-25 86.5 1.9 1.2e-24 85.8 1.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S27a ubiquitin PF00240.18 CDI79760.1 - 2.3e-12 46.1 0.0 4.4e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CDI79760.1 - 1.5e-07 30.9 0.0 4.1e-07 29.5 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDI79760.1 - 0.014 15.5 0.0 0.12 12.6 0.0 2.1 1 1 0 1 1 1 0 Ubiquitin-like domain IBR PF01485.16 CDI79760.1 - 0.015 15.1 1.3 0.023 14.5 0.9 1.3 1 0 0 1 1 1 0 IBR domain Stig1 PF04885.8 CDI79760.1 - 0.024 14.8 0.7 0.032 14.4 0.5 1.2 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 Cucumo_2B PF03263.8 CDI79760.1 - 0.084 13.1 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 Cucumovirus protein 2B Telomere_Sde2 PF13019.1 CDI79760.1 - 0.11 12.2 0.0 0.11 12.2 0.0 1.6 1 1 1 2 2 2 0 Telomere stability and silencing EF_TS PF00889.14 CDI79761.1 - 8.4e-33 113.5 0.3 2.3e-32 112.1 0.2 1.6 1 1 0 1 1 1 1 Elongation factor TS UBA PF00627.26 CDI79761.1 - 4.7e-08 32.6 0.1 1.2e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 CDI79761.1 - 0.046 13.2 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain Pkinase PF00069.20 CDI79763.1 - 9.9e-42 142.8 5.6 8.7e-34 116.8 0.0 4.5 5 0 0 5 5 5 4 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79763.1 - 6.8e-20 71.2 0.2 3.2e-17 62.4 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 CDI79763.1 - 0.00048 19.2 0.1 0.00048 19.2 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDI79763.1 - 0.0013 18.5 5.6 0.0071 16.0 0.8 4.3 4 2 1 5 5 5 2 Phosphotransferase enzyme family Sec23_trunk PF04811.10 CDI79764.1 - 4.1e-54 183.5 0.0 2.6e-50 171.0 0.0 2.2 2 0 0 2 2 2 2 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 CDI79764.1 - 2.2e-16 60.1 0.0 3.9e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 CDI79764.1 - 2.2e-15 55.9 4.7 3.9e-15 55.1 3.3 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 CDI79764.1 - 0.00013 21.6 0.0 0.00013 21.6 0.0 2.7 3 0 0 3 3 3 1 Gelsolin repeat Sec23_helical PF04815.10 CDI79764.1 - 0.0008 18.8 0.0 0.0026 17.1 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 helical domain PAT1 PF09770.4 CDI79764.1 - 4.5 5.3 44.9 8.6 4.4 31.1 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3123 PF11321.3 CDI79765.1 - 2.5 8.4 11.7 4.2 7.7 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Prp18 PF02840.10 CDI79766.1 - 1.2e-57 193.8 0.5 1.2e-57 193.8 0.3 3.0 3 1 0 3 3 3 1 Prp18 domain PRP4 PF08799.6 CDI79766.1 - 4.4e-13 48.2 1.1 4.4e-13 48.2 0.8 2.0 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like RP-C_C PF11800.3 CDI79766.1 - 1.4 8.5 10.8 0.16 11.6 2.4 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region RRM_1 PF00076.17 CDI79767.1 - 2.1e-13 49.6 0.0 3.4e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79767.1 - 8.9e-13 48.0 0.0 1.5e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 CDI79767.1 - 1.2e-09 38.0 0.1 1.2e-09 38.0 0.1 2.2 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 NABP PF07990.7 CDI79767.1 - 0.0027 17.0 1.3 0.0051 16.1 0.9 1.4 1 0 0 1 1 1 1 Nucleic acid binding protein NABP RRM_5 PF13893.1 CDI79767.1 - 0.048 13.5 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mmp37 PF09139.6 CDI79767.1 - 0.076 12.0 0.2 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 Borrelia_P83 PF05262.6 CDI79767.1 - 6.5 4.8 7.9 9.4 4.3 5.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein VCX_VCY PF15231.1 CDI79769.1 - 0.071 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Variable charge X/Y family CP_ATPgrasp_1 PF04174.8 CDI79769.1 - 0.16 10.5 0.4 0.72 8.4 0.0 2.0 2 1 0 2 2 2 0 A circularly permuted ATPgrasp AP2 PF00847.15 CDI79770.1 - 9.9e-06 25.6 0.5 9.9e-06 25.6 0.3 7.3 11 0 0 11 11 11 1 AP2 domain UPRTase PF14681.1 CDI79771.1 - 2.9e-67 225.9 0.0 4.4e-67 225.2 0.0 1.3 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 CDI79771.1 - 4.8e-09 36.0 0.0 9.3e-09 35.0 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain CTP_transf_1 PF01148.15 CDI79772.1 - 0.0035 17.0 0.8 0.045 13.4 0.0 2.4 2 1 0 2 2 2 1 Cytidylyltransferase family Macoilin PF09726.4 CDI79772.1 - 0.2 9.9 4.9 0.28 9.4 3.4 1.3 1 0 0 1 1 1 0 Transmembrane protein MFMR PF07777.6 CDI79772.1 - 0.75 9.6 13.5 1.7 8.5 9.4 1.5 1 0 0 1 1 1 0 G-box binding protein MFMR SR-25 PF10500.4 CDI79772.1 - 6.4 6.1 17.6 9.9 5.5 12.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WES_acyltransf PF03007.11 CDI79775.1 - 5.8e-05 22.7 2.0 0.00013 21.6 0.1 2.5 2 1 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.8 CDI79775.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1298) SNF PF00209.13 CDI79777.1 - 1.1e-20 73.6 38.4 1.2e-20 73.5 22.2 2.2 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family VIT1 PF01988.14 CDI79778.1 - 4e-55 186.6 2.1 3e-43 147.8 0.0 2.0 1 1 1 2 2 2 2 VIT family DUF4064 PF13273.1 CDI79778.1 - 0.019 15.0 2.2 0.35 10.9 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) DUF1079 PF06435.6 CDI79778.1 - 1.9 8.4 4.3 2.5 8.1 1.0 2.1 1 1 1 2 2 2 0 Repeat of unknown function (DUF1079) EF-hand_7 PF13499.1 CDI79779.1 - 1.9e-16 59.9 0.0 1.1e-07 31.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDI79779.1 - 1.8e-15 55.0 0.0 0.0027 16.8 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 CDI79779.1 - 5.8e-12 44.4 0.0 0.021 14.6 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 CDI79779.1 - 1.5e-09 36.7 0.0 0.11 11.8 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 CDI79779.1 - 1.4e-06 27.8 0.7 0.63 9.7 0.0 3.9 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.1 CDI79779.1 - 1.9e-06 27.6 0.0 0.015 15.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 CDI79779.1 - 0.071 13.1 0.0 10 6.2 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region HipA_C PF07804.7 CDI79781.1 - 0.022 14.8 0.0 0.073 13.1 0.0 1.9 1 0 0 1 1 1 0 HipA-like C-terminal domain FHA PF00498.21 CDI79783.1 - 0.00014 21.9 0.1 0.0016 18.5 0.0 2.1 2 0 0 2 2 2 1 FHA domain Glutaredoxin PF00462.19 CDI79785.1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin XRN_N PF03159.13 CDI79786.1 - 4.3e-85 284.8 0.0 6.9e-85 284.2 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus ApoLp-III PF07464.6 CDI79787.1 - 0.0086 16.1 2.8 0.0086 16.1 2.0 2.4 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) DUF1539 PF07560.6 CDI79787.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) CDK5_activator PF03261.10 CDI79787.1 - 0.26 10.6 1.9 0.5 9.6 1.3 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein HK97-gp10_like PF04883.7 CDI79787.1 - 0.94 10.4 7.6 0.7 10.8 1.4 3.0 2 1 1 3 3 3 0 Bacteriophage HK97-gp10, putative tail-component DUF4473 PF14747.1 CDI79787.1 - 1 9.6 9.0 0.23 11.6 0.8 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4473) DUF883 PF05957.8 CDI79787.1 - 1.3 9.4 15.1 0.27 11.6 1.6 3.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Daxx PF03344.10 CDI79788.1 - 8.8e-07 27.8 32.9 8.8e-07 27.8 22.8 4.4 4 0 0 4 4 4 2 Daxx Family Spore_coat_CotO PF14153.1 CDI79788.1 - 8.7e-05 22.0 17.8 8.7e-05 22.0 12.4 6.4 9 0 0 9 9 9 2 Spore coat protein CotO CDC45 PF02724.9 CDI79788.1 - 0.0002 19.5 18.3 0.0002 19.5 12.7 3.7 4 0 0 4 4 4 1 CDC45-like protein DNA_pol_phi PF04931.8 CDI79788.1 - 0.019 12.7 0.0 0.019 12.7 0.0 4.3 3 1 0 3 3 3 0 DNA polymerase phi AAA_23 PF13476.1 CDI79788.1 - 2.3 8.4 0.0 2.3 8.4 0.0 6.1 5 3 0 5 5 5 0 AAA domain BUD22 PF09073.5 CDI79790.1 - 0.015 14.3 1.7 0.018 14.1 1.2 1.1 1 0 0 1 1 1 0 BUD22 Myc_target_1 PF15179.1 CDI79790.1 - 0.031 13.8 2.8 0.072 12.6 1.9 1.5 1 0 0 1 1 1 0 Myc target protein 1 ABC_tran PF00005.22 CDI79791.1 - 4.4e-21 75.6 2.2 4.4e-21 75.6 1.5 5.2 3 2 0 3 3 3 1 ABC transporter AAA_21 PF13304.1 CDI79791.1 - 3.7e-08 33.6 0.0 3.1e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CDI79791.1 - 0.0019 17.7 0.0 0.0057 16.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4647 PF15504.1 CDI79791.1 - 0.0026 16.6 2.0 0.0026 16.6 1.4 5.1 4 1 1 5 5 5 1 Domain of unknown function (DUF4647) AAA_15 PF13175.1 CDI79791.1 - 0.0027 16.8 0.0 0.61 9.0 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain SR-25 PF10500.4 CDI79791.1 - 0.004 16.6 0.4 0.004 16.6 0.3 7.2 4 2 2 6 6 6 1 Nuclear RNA-splicing-associated protein BAF1_ABF1 PF04684.8 CDI79791.1 - 0.0047 15.8 11.0 0.0047 15.8 7.7 12.1 6 3 7 14 14 14 2 BAF1 / ABF1 chromatin reorganising factor CDK2AP PF09806.4 CDI79791.1 - 0.0053 17.0 2.8 0.0053 17.0 2.0 10.5 4 3 3 7 7 7 1 Cyclin-dependent kinase 2-associated protein Miro PF08477.8 CDI79791.1 - 0.016 15.6 0.3 0.016 15.6 0.2 3.3 2 1 1 3 3 3 0 Miro-like protein DUF1620 PF07774.8 CDI79792.1 - 2.8e-15 56.1 0.0 2.3e-14 53.2 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 CDI79792.1 - 8.5e-12 45.0 16.5 6.5e-07 29.0 4.0 3.5 3 1 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 CDI79792.1 - 1.6e-08 33.6 0.2 0.84 9.2 0.1 4.5 4 0 0 4 4 4 3 PQQ enzyme repeat DOPA_dioxygen PF08883.6 CDI79792.1 - 0.085 12.9 0.0 0.33 11.0 0.0 2.0 1 0 0 1 1 1 0 Dopa 4,5-dioxygenase family Peptidase_M56 PF05569.6 CDI79793.1 - 0.1 11.5 11.0 0.17 10.8 2.0 4.0 3 0 0 3 3 3 0 BlaR1 peptidase M56 Porin_3 PF01459.17 CDI79794.1 - 1.3e-17 64.0 0.0 1.5e-17 63.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Pkinase PF00069.20 CDI79795.1 - 1.6e-11 43.8 5.2 1.9e-06 27.2 1.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79795.1 - 0.0043 16.1 0.2 2.6 7.0 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase ETRAMP PF09716.5 CDI79795.1 - 0.63 10.0 0.0 0.63 10.0 0.0 6.8 8 2 1 9 9 9 0 Malarial early transcribed membrane protein (ETRAMP) HdeA PF06411.6 CDI79797.1 - 0.00082 19.2 2.7 0.017 15.1 0.1 2.2 2 0 0 2 2 2 2 HdeA/HdeB family CReP_N PF10472.4 CDI79797.1 - 0.021 13.5 0.1 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor DUF3235 PF11574.3 CDI79797.1 - 0.54 10.5 10.0 1.2 9.4 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) Spt5_N PF11942.3 CDI79798.1 - 1.8e-08 34.8 10.7 1.8e-08 34.8 7.4 3.7 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal Spt5-NGN PF03439.8 CDI79798.1 - 2.7e-06 27.0 0.0 8.6e-06 25.4 0.0 1.9 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section SPG48 PF14764.1 CDI79800.1 - 2e-08 33.1 1.0 1.9e-07 29.9 0.0 2.9 4 0 0 4 4 4 1 AP-5 complex subunit, vesicle trafficking DUF3311 PF11755.3 CDI79800.1 - 0.03 13.8 0.1 0.19 11.3 0.1 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3311) DUF4175 PF13779.1 CDI79800.1 - 0.12 10.0 49.4 0.35 8.5 20.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) FimP PF09766.4 CDI79800.1 - 0.16 11.0 25.5 0.041 12.9 6.1 2.4 2 0 0 2 2 2 0 Fms-interacting protein Serinc PF03348.10 CDI79800.1 - 0.48 9.0 8.0 0.75 8.4 1.4 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF912 PF06024.7 CDI79800.1 - 0.66 10.0 6.8 5.3 7.1 1.9 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PAT1 PF09770.4 CDI79800.1 - 1.2 7.2 41.4 1.1 7.3 4.8 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.6 CDI79800.1 - 2.4 7.2 4.9 0.96 8.5 0.6 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF3899 PF13038.1 CDI79800.1 - 3.6 7.8 4.6 2.1 8.5 0.1 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF3899) Neur_chan_memb PF02932.11 CDI79800.1 - 4.7 7.0 14.1 1.5 8.6 3.6 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region AAA_23 PF13476.1 CDI79800.1 - 5.6 7.2 22.0 2.3 8.5 6.1 2.3 2 0 0 2 2 2 0 AAA domain zf-DHHC PF01529.15 CDI79800.1 - 6.6 6.1 9.8 1.1 8.6 2.2 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase TMEM51 PF15345.1 CDI79800.1 - 8 6.0 20.8 4 7.0 8.3 2.6 2 0 0 2 2 2 0 Transmembrane protein 51 DUF3801 PF12687.2 CDI79802.1 - 0.0021 17.6 3.0 0.0021 17.6 2.1 4.2 4 0 0 4 4 4 2 Protein of unknown function (DUF3801) Med15 PF09606.5 CDI79802.1 - 5.7 5.0 95.1 0.46 8.6 16.8 3.5 2 1 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal LysM PF01476.15 CDI79803.1 - 1.7e-09 37.4 0.0 5.2e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 LysM domain Pex14_N PF04695.8 CDI79805.1 - 0.034 14.1 9.7 0.23 11.4 6.7 2.0 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ndc1_Nup PF09531.5 CDI79805.1 - 1.3 7.3 3.9 1.5 7.1 2.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4614 PF15391.1 CDI79805.1 - 2.6 7.7 9.7 3.5 7.3 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) SOG2 PF10428.4 CDI79805.1 - 6.8 5.2 12.0 10 4.6 8.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4175 PF13779.1 CDI79807.1 - 4.3 4.9 7.7 4.6 4.8 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF853 PF05872.7 CDI79807.1 - 5.5 5.2 12.0 6.5 4.9 8.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Proteasome PF00227.21 CDI79809.1 - 8.3e-20 70.8 0.0 1e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit FBPase PF00316.15 CDI79810.1 - 2.6e-120 401.1 0.0 3.2e-120 400.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Beach PF02138.13 CDI79812.1 - 1.3e-66 224.8 0.0 1.6e-39 135.9 0.0 2.9 2 1 0 2 2 2 2 Beige/BEACH domain WD40 PF00400.27 CDI79812.1 - 0.0002 21.1 6.7 0.00057 19.6 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Ribosomal_60s PF00428.14 CDI79813.1 - 1.3 9.4 46.8 0.33 11.3 6.8 4.7 5 0 0 5 5 5 0 60s Acidic ribosomal protein DUF724 PF05266.9 CDI79814.1 - 2.4 7.7 8.1 3.8 7.0 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF2910 PF11139.3 CDI79815.1 - 1.5 7.9 28.4 2.1 7.4 19.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2910) DUF2217 PF10265.4 CDI79815.1 - 2.6 6.7 10.0 3.1 6.4 6.7 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 CDI79815.1 - 6.6 4.8 14.2 8.4 4.5 9.9 1.1 1 0 0 1 1 1 0 Transmembrane protein Hamartin PF04388.7 CDI79815.1 - 8.6 4.9 14.5 9.7 4.7 10.0 1.1 1 0 0 1 1 1 0 Hamartin protein Methyltransf_16 PF10294.4 CDI79816.1 - 8.7e-08 31.8 0.2 0.019 14.4 0.0 2.8 2 1 0 2 2 2 2 Putative methyltransferase Methyltransf_23 PF13489.1 CDI79816.1 - 0.00013 21.7 0.0 0.00053 19.7 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDI79816.1 - 0.0017 17.7 0.1 0.0047 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CDI79816.1 - 0.012 14.7 0.0 0.012 14.7 0.0 2.1 2 1 1 3 3 3 0 Ribosomal protein L11 methyltransferase (PrmA) DUF4414 PF14377.1 CDI79816.1 - 0.039 13.8 27.4 0.061 13.2 3.3 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4414) Methyltransf_12 PF08242.7 CDI79816.1 - 0.92 10.0 6.4 25 5.4 1.1 3.6 3 1 0 3 3 3 0 Methyltransferase domain Methyltransf_26 PF13659.1 CDI79816.1 - 2.6 8.1 17.1 1.2 9.1 5.3 3.4 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 CDI79816.1 - 4.1 8.0 15.0 13 6.4 7.8 3.2 2 1 0 2 2 2 0 Methyltransferase domain Med15 PF09606.5 CDI79818.1 - 0.88 7.6 52.2 0.035 12.3 8.6 3.1 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3371 PF11851.3 CDI79818.1 - 4.2 8.0 27.9 0.038 14.6 3.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF3371) URO-D PF01208.12 CDI79819.1 - 3.1e-77 259.8 0.2 2.3e-71 240.5 0.0 2.2 1 1 1 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) Ribosomal_60s PF00428.14 CDI79819.1 - 6.2 7.2 18.4 1.6 9.1 5.8 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein Macoilin PF09726.4 CDI79819.1 - 8.1 4.5 14.7 10 4.2 10.2 1.1 1 0 0 1 1 1 0 Transmembrane protein PARG_cat PF05028.9 CDI79820.1 - 3.1e-41 141.7 0.1 4.4e-19 68.9 0.0 3.9 4 0 0 4 4 4 3 Poly (ADP-ribose) glycohydrolase (PARG) Ribosomal_L14 PF00238.14 CDI79820.1 - 1.1e-11 44.5 0.0 1.7e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e HemY_N PF07219.8 CDI79822.1 - 0.00084 18.8 0.5 0.0018 17.7 0.3 1.5 1 0 0 1 1 1 1 HemY protein N-terminus Amnionless PF14828.1 CDI79822.1 - 0.0045 15.5 0.1 0.0067 14.9 0.1 1.2 1 0 0 1 1 1 1 Amnionless MCM_N PF14551.1 CDI79823.1 - 1.7e-08 34.9 0.0 2.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 MCM N-terminal domain MCM PF00493.18 CDI79826.1 - 3.1e-82 276.0 8.0 6.1e-56 189.6 0.2 5.4 4 2 1 5 5 5 3 MCM2/3/5 family DASH_Dam1 PF08653.5 CDI79826.1 - 0.18 11.5 8.7 0.87 9.4 1.0 3.0 2 0 0 2 2 2 0 DASH complex subunit Dam1 Macoilin PF09726.4 CDI79830.1 - 0.0085 14.4 27.9 0.01 14.1 19.3 1.0 1 0 0 1 1 1 1 Transmembrane protein Ycf1 PF05758.7 CDI79830.1 - 0.061 11.0 13.1 0.065 10.9 9.1 1.0 1 0 0 1 1 1 0 Ycf1 eIF-3_zeta PF05091.7 CDI79830.1 - 0.16 10.5 21.2 0.18 10.4 14.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AIP3 PF03915.8 CDI79830.1 - 0.16 10.8 23.2 0.2 10.4 16.1 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DUF966 PF06136.8 CDI79830.1 - 0.25 10.7 30.0 0.37 10.1 20.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CDC45 PF02724.9 CDI79830.1 - 0.91 7.4 16.3 1.1 7.1 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein AAA_13 PF13166.1 CDI79830.1 - 1.6 7.1 15.5 2.1 6.7 10.7 1.2 1 0 0 1 1 1 0 AAA domain Asp-B-Hydro_N PF05279.6 CDI79830.1 - 2 8.2 14.6 2.4 7.9 10.1 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CRT10 PF08728.5 CDI79830.1 - 2.1 6.2 10.0 2.5 5.9 6.9 1.0 1 0 0 1 1 1 0 CRT10 Cellulose_synt PF03552.9 CDI79830.1 - 2.3 6.4 7.1 2.6 6.2 4.9 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF106 PF01956.11 CDI79830.1 - 2.7 7.4 11.6 3.3 7.2 8.0 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF106 MIP-T3 PF10243.4 CDI79830.1 - 3.5 5.9 38.7 4.4 5.6 26.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 LMBR1 PF04791.11 CDI79830.1 - 3.7 6.0 6.5 4 5.8 4.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF572 PF04502.8 CDI79830.1 - 4.5 6.3 31.2 5.7 6.0 21.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Mitofilin PF09731.4 CDI79830.1 - 4.6 5.7 36.6 7.2 5.1 25.4 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PA26 PF04636.8 CDI79830.1 - 6.8 5.2 13.0 7 5.2 9.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DDRGK PF09756.4 CDI79830.1 - 7.3 5.9 29.1 10 5.4 20.2 1.2 1 0 0 1 1 1 0 DDRGK domain PIG-S PF10510.4 CDI79830.1 - 8.4 4.9 22.3 11 4.6 15.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF745 PF05335.8 CDI79831.1 - 0.0028 17.1 4.5 0.0028 17.1 3.1 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF745) WEMBL PF05701.6 CDI79831.1 - 0.059 11.8 28.9 0.081 11.3 20.0 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light AAA_13 PF13166.1 CDI79831.1 - 0.061 11.7 25.7 0.077 11.4 17.8 1.0 1 0 0 1 1 1 0 AAA domain Cob_adeno_trans PF01923.13 CDI79831.1 - 0.11 12.2 11.9 0.014 15.2 4.6 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase RasGAP_C PF03836.10 CDI79831.1 - 0.36 10.4 15.3 0.029 14.0 4.9 2.5 1 1 0 2 2 2 0 RasGAP C-terminus DUF2935 PF11155.3 CDI79831.1 - 0.78 9.8 10.6 0.92 9.6 5.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Fez1 PF06818.10 CDI79831.1 - 0.93 9.4 27.3 2.9 7.8 6.9 2.1 1 1 1 2 2 2 0 Fez1 Methyltransf_25 PF13649.1 CDI79831.1 - 4.1 7.8 5.7 16 5.9 0.2 2.9 1 1 2 3 3 3 0 Methyltransferase domain DUF1664 PF07889.7 CDI79831.1 - 7 6.4 13.4 0.3 10.8 1.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) RNA_binding PF01877.12 CDI79831.1 - 8.2 6.4 12.8 0.61 10.1 3.0 2.4 1 1 1 2 2 2 0 RNA binding NPV_P10 PF05531.7 CDI79831.1 - 10 6.4 10.1 14 5.9 0.3 3.0 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Kinesin PF00225.18 CDI79832.1 - 3.9e-89 298.6 0.0 5.9e-89 298.0 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain PRCC PF10253.4 CDI79833.1 - 0.043 14.5 0.5 0.063 13.9 0.3 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting MSP1_C PF07462.6 CDI79833.1 - 8.9 4.5 5.9 11 4.2 4.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Sporozoite_P67 PF05642.6 CDI79834.1 - 6.1e-06 24.4 0.5 6.1e-06 24.4 0.3 6.6 7 1 0 7 7 7 2 Sporozoite P67 surface antigen Activator_LAG-3 PF11498.3 CDI79834.1 - 0.0015 17.3 8.6 0.0015 17.3 5.9 8.2 8 1 0 8 8 8 2 Transcriptional activator LAG-3 GvpO PF05800.6 CDI79835.1 - 0.046 13.6 0.0 0.074 12.9 0.0 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpO Med3 PF11593.3 CDI79835.1 - 0.057 12.6 0.3 0.059 12.6 0.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SAC3_GANP PF03399.11 CDI79836.1 - 4e-16 59.1 7.6 7.2e-16 58.3 4.9 1.6 1 1 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 CDI79836.1 - 3.4e-13 49.5 1.0 3.4e-13 49.5 0.7 2.8 4 0 0 4 4 4 1 COP9 signalosome, subunit CSN8 PCI PF01399.22 CDI79836.1 - 0.013 15.7 0.6 0.013 15.7 0.4 2.7 3 0 0 3 3 3 0 PCI domain RskA PF10099.4 CDI79836.1 - 3.7 7.2 18.0 2 8.1 6.8 2.6 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Phage_Gp23 PF10669.4 CDI79836.1 - 6.3 6.9 15.1 7.8 6.6 0.2 3.7 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) Pkinase PF00069.20 CDI79837.1 - 5.5e-38 130.5 18.8 1.4e-16 60.4 0.0 4.4 5 0 0 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79837.1 - 1.3e-21 76.8 2.2 1.8e-13 50.1 2.9 3.3 2 1 0 2 2 2 2 Protein tyrosine kinase EF-hand_6 PF13405.1 CDI79837.1 - 0.2 11.6 0.0 0.58 10.1 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 CDI79837.1 - 0.37 10.9 0.0 1.6 8.8 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair Suf PF05843.9 CDI79838.1 - 0.2 11.3 4.1 6.8 6.3 0.3 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) MIR PF02815.14 CDI79839.1 - 0.023 14.2 4.6 0.027 14.0 3.2 1.1 1 0 0 1 1 1 0 MIR domain Med15 PF09606.5 CDI79839.1 - 0.11 10.6 12.6 0.11 10.6 8.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4557 PF15101.1 CDI79839.1 - 1.5 8.5 5.3 1.5 8.6 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Activator_LAG-3 PF11498.3 CDI79839.1 - 2.3 6.8 17.0 2.6 6.6 11.8 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HTH_17 PF12728.2 CDI79840.1 - 0.24 11.6 0.0 0.55 10.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Cnd1 PF12717.2 CDI79842.1 - 2.4e-10 40.5 0.0 2.4e-10 40.5 0.0 5.5 7 1 1 8 8 8 1 non-SMC mitotic condensation complex subunit 1 CDC45 PF02724.9 CDI79842.1 - 3e-05 22.2 9.2 3e-05 22.2 6.3 6.9 7 0 0 7 7 7 3 CDC45-like protein HEAT PF02985.17 CDI79842.1 - 0.22 11.6 22.0 3.9 7.8 0.1 7.4 8 0 0 8 8 8 0 HEAT repeat Rieske PF00355.21 CDI79843.1 - 4.6e-08 32.5 0.1 1.2e-07 31.1 0.1 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 CDI79843.1 - 9.6e-05 22.0 0.1 0.00024 20.7 0.0 1.7 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Med15 PF09606.5 CDI79844.1 - 0.00068 17.9 34.9 0.00068 17.9 24.2 8.8 10 1 0 10 10 10 1 ARC105 or Med15 subunit of Mediator complex non-fungal SPX PF03105.14 CDI79844.1 - 0.0016 18.2 0.0 0.0016 18.2 0.0 7.5 7 1 0 7 7 7 3 SPX domain GAF PF01590.21 CDI79845.1 - 8.9e-09 35.6 0.3 3.3e-08 33.7 0.0 2.1 2 0 0 2 2 2 1 GAF domain GAF_2 PF13185.1 CDI79845.1 - 3.5e-08 34.0 0.9 1e-07 32.5 0.0 2.1 2 1 0 2 2 2 1 GAF domain GAF_3 PF13492.1 CDI79845.1 - 0.00016 21.7 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 GAF domain DUF755 PF05501.6 CDI79845.1 - 0.0013 18.7 8.1 0.0013 18.7 5.6 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF755) Sporozoite_P67 PF05642.6 CDI79845.1 - 0.0014 16.5 12.5 0.0018 16.2 8.6 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen CDC45 PF02724.9 CDI79845.1 - 0.054 11.5 7.4 0.089 10.8 5.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Suf PF05843.9 CDI79845.1 - 0.11 12.1 3.3 0.17 11.5 2.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2453 PF10507.4 CDI79846.1 - 7.7e-09 35.3 0.0 0.0002 21.1 0.0 3.6 3 1 1 4 4 4 2 Protein of unknown function (DUF2453) Pex14_N PF04695.8 CDI79846.1 - 0.036 14.0 0.6 0.036 14.0 0.4 6.6 2 2 3 6 6 6 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FHIPEP PF00771.15 CDI79846.1 - 1 7.6 5.5 1.8 6.7 3.8 1.3 1 0 0 1 1 1 0 FHIPEP family Fra10Ac1 PF09725.4 CDI79848.1 - 2.7e-12 46.8 0.5 1.7e-08 34.5 0.0 2.5 3 0 0 3 3 3 2 Folate-sensitive fragile site protein Fra10Ac1 DEAD PF00270.24 CDI79849.1 - 1e-11 44.6 0.1 2.8e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pro-rich PF15240.1 CDI79850.1 - 1.3 9.0 52.6 0.57 10.2 32.9 2.2 2 0 0 2 2 2 0 Proline-rich Atg8 PF02991.11 CDI79851.1 - 6.7e-33 112.7 0.1 1.2e-32 111.9 0.1 1.4 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 CDI79851.1 - 1.5e-05 25.0 0.1 4.7e-05 23.4 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Dala_Dala_lig_N PF01820.16 CDI79853.1 - 0.11 12.8 5.7 3 8.1 0.9 4.2 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus FoP_duplication PF13865.1 CDI79854.1 - 4.1e-10 39.9 18.2 6.6e-09 36.1 12.6 2.7 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 DUF2344 PF10105.4 CDI79854.1 - 0.025 14.0 0.9 0.042 13.3 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) DUF1421 PF07223.6 CDI79854.1 - 0.78 9.4 30.7 1.1 8.9 21.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1421) PAT1 PF09770.4 CDI79854.1 - 3.9 5.5 27.1 4.7 5.3 18.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ala_racemase_N PF01168.15 CDI79855.1 - 1.1e-37 129.7 1.8 1.1e-37 129.7 1.3 2.5 2 1 0 2 2 2 1 Alanine racemase, N-terminal domain TFIIA PF03153.8 CDI79855.1 - 0.0077 16.1 19.5 0.0099 15.8 13.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.3 CDI79855.1 - 0.027 13.8 1.1 0.04 13.2 0.8 1.3 1 0 0 1 1 1 0 Spt20 family Miff PF05644.6 CDI79855.1 - 0.038 13.6 2.5 0.07 12.7 1.7 1.4 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Hid1 PF12722.2 CDI79855.1 - 0.087 10.4 1.6 0.12 10.0 1.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF912 PF06024.7 CDI79855.1 - 0.28 11.2 2.6 2.2 8.3 0.3 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Hamartin PF04388.7 CDI79855.1 - 0.7 8.4 4.6 0.98 8.0 3.2 1.1 1 0 0 1 1 1 0 Hamartin protein PAT1 PF09770.4 CDI79855.1 - 1.6 6.8 23.3 2.4 6.2 16.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_DNAp_acc PF04929.7 CDI79855.1 - 5.1 5.9 6.3 7.5 5.4 4.3 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CRIC_ras_sig PF10534.4 CDI79857.1 - 4.6 7.3 7.4 0.62 10.1 1.5 2.0 1 1 0 2 2 2 0 Connector enhancer of kinase suppressor of ras DUF2052 PF09747.4 CDI79857.1 - 7.2 6.4 8.7 9.8 6.0 6.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LETM1 PF07766.8 CDI79859.1 - 3.5e-64 216.4 3.3 3.5e-64 216.4 2.3 2.3 3 0 0 3 3 3 1 LETM1-like protein RNA_replicase_B PF03431.8 CDI79859.1 - 0.17 10.0 1.9 0.23 9.6 0.3 1.8 2 0 0 2 2 2 0 RNA replicase, beta-chain DUF2763 PF10961.3 CDI79859.1 - 1.7 9.1 8.0 0.11 12.8 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) PITH PF06201.8 CDI79861.1 - 5.6e-18 65.1 0.0 1.2e-17 64.0 0.0 1.6 2 0 0 2 2 2 1 PITH domain Med3 PF11593.3 CDI79861.1 - 1.8 7.7 18.6 2.6 7.2 12.9 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Macoilin PF09726.4 CDI79861.1 - 3.6 5.7 9.5 4.1 5.5 6.6 1.0 1 0 0 1 1 1 0 Transmembrane protein TFIIA PF03153.8 CDI79861.1 - 8.9 6.0 13.8 10 5.8 9.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DnaJ PF00226.26 CDI79863.1 - 8.6e-11 41.4 0.0 2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain GTA_TIM PF13547.1 CDI79863.1 - 0.0079 15.2 3.1 0.011 14.7 2.2 1.2 1 0 0 1 1 1 1 GTA TIM-barrel-like domain Laminin_G_3 PF13385.1 CDI79867.1 - 4.1e-18 66.0 0.0 1.3e-17 64.4 0.0 1.8 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sialidase PF02973.11 CDI79867.1 - 0.072 12.0 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Sialidase, N-terminal domain Laminin_G_2 PF02210.19 CDI79867.1 - 0.1 12.6 0.0 0.48 10.4 0.0 2.1 1 1 0 1 1 1 0 Laminin G domain ACDC PF14733.1 CDI79868.1 - 7.7e-15 54.8 0.1 1.5e-14 53.8 0.1 1.5 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.15 CDI79868.1 - 5.7e-07 29.5 4.4 1.5e-06 28.2 3.0 1.8 1 0 0 1 1 1 1 AP2 domain ATP-sulfurylase PF01747.12 CDI79869.1 - 1.6e-60 204.1 0.0 2.3e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.15 CDI79869.1 - 2.1e-39 134.7 0.5 1.6e-37 128.6 0.1 3.0 2 1 0 2 2 2 1 Adenylylsulphate kinase PUA_2 PF14306.1 CDI79869.1 - 3.9e-32 110.8 0.1 3e-31 108.0 0.0 2.0 1 1 0 1 1 1 1 PUA-like domain AAA_33 PF13671.1 CDI79869.1 - 0.003 17.4 0.0 0.0075 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Spore_YhaL PF14147.1 CDI79869.1 - 0.096 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein YhaL CIAPIN1 PF05093.8 CDI79870.1 - 1.5e-24 85.9 14.1 7.5e-24 83.7 9.8 1.9 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GpcrRhopsn4 PF10192.4 CDI79871.1 - 0.0052 15.9 0.2 0.0083 15.3 0.1 1.2 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain HXXEE PF13787.1 CDI79871.1 - 0.077 13.3 0.6 0.31 11.4 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif DUF4131 PF13567.1 CDI79871.1 - 8.6 5.7 9.6 4.5 6.6 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) LMBR1 PF04791.11 CDI79873.1 - 0.2 10.1 2.7 0.34 9.4 1.9 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Oleosin PF01277.12 CDI79874.1 - 0.00093 18.7 0.5 0.0036 16.8 0.0 2.3 2 0 0 2 2 2 1 Oleosin Serinc PF03348.10 CDI79874.1 - 0.13 10.9 0.6 0.28 9.8 0.4 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) Folate_carrier PF01770.13 CDI79874.1 - 0.2 10.1 1.0 0.43 9.0 0.7 1.5 1 0 0 1 1 1 0 Reduced folate carrier Pex14_N PF04695.8 CDI79874.1 - 0.88 9.6 12.4 1.3 9.0 2.2 3.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Prominin PF05478.6 CDI79875.1 - 0.026 12.1 1.3 0.048 11.2 0.9 1.4 1 0 0 1 1 1 0 Prominin AP_endonuc_2 PF01261.19 CDI79875.1 - 0.055 12.7 0.1 0.25 10.6 0.0 2.0 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel FliE PF02049.13 CDI79876.1 - 1.1 9.2 10.5 0.2 11.6 1.4 3.2 3 0 0 3 3 3 0 Flagellar hook-basal body complex protein FliE Pex14_N PF04695.8 CDI79879.1 - 6.9 6.7 16.0 2.4 8.1 2.7 3.6 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hydrolase_4 PF12146.3 CDI79880.1 - 2e-09 37.1 0.7 3.1e-05 23.7 0.1 2.7 2 0 0 2 2 2 2 Putative lysophospholipase LMBR1 PF04791.11 CDI79880.1 - 7.2 5.0 6.7 17 3.8 4.7 1.6 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.27 CDI79881.1 - 4.7e-09 35.7 12.8 0.014 15.2 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Exonuc_VII_L PF02601.10 CDI79881.1 - 8.3e-06 25.2 1.9 8.3e-06 25.2 1.3 7.3 4 2 0 4 4 4 1 Exonuclease VII, large subunit BTB PF00651.26 CDI79882.1 - 1.2e-06 28.4 0.3 7.9e-06 25.8 0.2 2.3 1 1 0 1 1 1 1 BTB/POZ domain DUF4557 PF15101.1 CDI79882.1 - 0.013 15.3 1.1 0.013 15.3 0.8 9.4 7 3 2 9 9 9 0 Domain of unknown function (DUF4557) Herpes_DNAp_acc PF04929.7 CDI79882.1 - 1.8 7.4 0.0 1.8 7.4 0.0 8.2 5 4 2 7 7 7 0 Herpes DNA replication accessory factor RRM_1 PF00076.17 CDI79884.1 - 3.3e-22 77.8 0.3 1.6e-16 59.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI79884.1 - 1e-15 57.4 0.1 6.2e-12 45.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI79884.1 - 5.3e-10 39.0 0.0 1.1e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Period_C PF12114.3 CDI79884.1 - 0.17 11.4 5.4 0.27 10.8 3.7 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Atrophin-1 PF03154.10 CDI79884.1 - 0.9 7.6 6.7 1 7.4 4.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family AF-4 PF05110.8 CDI79884.1 - 7.6 4.2 14.2 11 3.7 9.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DnaJ PF00226.26 CDI79885.1 - 7.8e-13 47.9 0.1 1.1e-12 47.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain DUF1229 PF06797.6 CDI79885.1 - 0.011 14.6 0.4 0.014 14.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) M16C_assoc PF08367.6 CDI79887.1 - 3.5e-45 153.8 0.1 6.3e-45 152.9 0.1 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 CDI79887.1 - 1.8e-24 86.4 0.1 5e-18 65.4 0.0 3.6 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CDI79887.1 - 9.5e-05 22.1 0.0 0.00062 19.5 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DNA_pol_A PF00476.15 CDI79889.1 - 4.7e-34 117.6 8.7 5e-31 107.6 1.7 5.0 3 1 0 3 3 3 2 DNA polymerase family A DUF3492 PF11997.3 CDI79890.1 - 0.056 12.9 3.1 0.24 10.8 2.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) DUF515 PF04415.7 CDI79892.1 - 8.9 4.4 12.5 30 2.6 8.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF2813 PF11398.3 CDI79893.1 - 0.32 10.0 15.1 0.44 9.5 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) SAS4 PF15460.1 CDI79893.1 - 0.74 9.7 9.6 1.3 8.9 6.7 1.4 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 SprA-related PF12118.3 CDI79893.1 - 6.6 5.9 27.6 0.59 9.4 0.3 2.1 2 0 0 2 2 2 0 SprA-related family RAP PF08373.5 CDI79894.1 - 0.012 15.3 0.0 0.042 13.6 0.0 2.1 1 0 0 1 1 1 0 RAP domain SR-25 PF10500.4 CDI79895.1 - 0.35 10.2 21.6 3.7 6.9 15.0 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3138 PF11336.3 CDI79895.1 - 9.8 4.2 9.3 0.85 7.7 3.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) WES_acyltransf PF03007.11 CDI79896.1 - 0.19 11.2 13.2 0.22 11.0 9.1 1.1 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Med15 PF09606.5 CDI79896.1 - 3.8 5.6 11.7 3.8 5.5 8.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SPX PF03105.14 CDI79897.1 - 1e-05 25.4 0.0 0.00043 20.1 0.0 2.7 1 1 0 1 1 1 1 SPX domain Mito_carr PF00153.22 CDI79897.1 - 0.017 14.8 11.4 0.048 13.3 2.6 4.4 4 1 0 4 4 4 0 Mitochondrial carrier protein SprA-related PF12118.3 CDI79897.1 - 0.68 9.2 41.7 0.21 10.8 2.7 3.3 3 0 0 3 3 3 0 SprA-related family CAF-1_p150 PF11600.3 CDI79897.1 - 4.8 6.4 39.7 0.18 11.1 5.6 3.1 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal IER PF05760.7 CDI79897.1 - 6.4 6.5 27.5 0.69 9.7 11.2 2.6 2 1 1 3 3 3 0 Immediate early response protein (IER) SR-25 PF10500.4 CDI79898.1 - 0.002 17.6 6.1 0.002 17.6 4.2 9.7 4 2 3 7 7 7 2 Nuclear RNA-splicing-associated protein OmpH PF03938.9 CDI79898.1 - 0.005 16.7 8.0 0.005 16.7 5.6 6.1 4 2 0 4 4 4 1 Outer membrane protein (OmpH-like) Fumble PF03630.9 CDI79899.1 - 4e-23 81.8 2.9 4e-23 81.8 2.0 3.4 2 2 0 2 2 2 1 Fumble Med15 PF09606.5 CDI79899.1 - 3.7e-05 22.1 173.2 0.0041 15.3 79.9 2.3 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal Ribosomal_60s PF00428.14 CDI79899.1 - 0.0031 17.8 3.0 0.0031 17.8 2.1 4.2 3 1 0 3 3 3 1 60s Acidic ribosomal protein PAT1 PF09770.4 CDI79899.1 - 0.0038 15.5 130.7 0.028 12.6 61.0 2.2 2 0 0 2 2 2 2 Topoisomerase II-associated protein PAT1 SOBP PF15279.1 CDI79899.1 - 0.74 10.1 53.9 0.65 10.3 5.6 2.5 2 0 0 2 2 2 0 Sine oculis-binding protein Utp14 PF04615.8 CDI79899.1 - 9.2 4.2 60.4 3.9 5.5 28.9 2.1 2 0 0 2 2 2 0 Utp14 protein Zip PF02535.17 CDI79900.1 - 1.6e-05 24.0 2.0 3.1e-05 23.1 1.4 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter Fumble PF03630.9 CDI79900.1 - 2.2e-05 23.4 0.1 2.2e-05 23.4 0.1 2.4 3 0 0 3 3 3 1 Fumble Spt20 PF12090.3 CDI79900.1 - 0.0073 15.6 11.6 0.083 12.2 0.1 2.1 2 0 0 2 2 2 2 Spt20 family OmpH PF03938.9 CDI79900.1 - 0.019 14.9 21.9 0.042 13.7 15.2 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Neur_chan_memb PF02932.11 CDI79900.1 - 0.1 12.4 1.4 0.27 11.1 1.0 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.8 CDI79900.1 - 1.2 8.9 27.9 2.5 7.9 2.5 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Claudin_2 PF13903.1 CDI79900.1 - 1.5 8.5 11.3 0.57 9.8 3.3 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction FimP PF09766.4 CDI79900.1 - 1.5 7.7 25.5 0.73 8.8 1.4 2.0 2 0 0 2 2 2 0 Fms-interacting protein RCR PF12273.3 CDI79900.1 - 4.2 7.9 17.0 1.6 9.2 0.6 2.2 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red DUF4207 PF13904.1 CDI79900.1 - 9 5.5 30.3 1.4 8.2 10.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) DUF3469 PF11952.3 CDI79901.1 - 1.6e-07 30.8 0.6 2.5e-07 30.3 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3469) Med15 PF09606.5 CDI79901.1 - 0.16 10.1 13.7 0.2 9.7 9.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3040 PF11239.3 CDI79901.1 - 0.4 10.7 0.2 0.4 10.7 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) IQ PF00612.22 CDI79904.1 - 0.0008 18.8 1.6 0.0015 17.9 0.3 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif RNA_pol_Rbc25 PF08292.7 CDI79904.1 - 0.012 15.8 1.4 0.038 14.1 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 PAT1 PF09770.4 CDI79904.1 - 1.3 7.1 28.1 1.9 6.6 19.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 OmpH PF03938.9 CDI79905.1 - 9.5 6.1 31.9 20 5.0 0.3 2.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) NuA4 PF09340.5 CDI79908.1 - 2.3e-18 65.5 0.0 4.4e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Ycf1 PF05758.7 CDI79910.1 - 2.4 5.7 7.8 1.4 6.4 1.4 2.1 2 0 0 2 2 2 0 Ycf1 DUF1115 PF06544.7 CDI79911.1 - 7e-19 67.7 2.8 1.1e-18 67.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Glycos_transf_1 PF00534.15 CDI79915.1 - 0.026 13.9 0.6 0.14 11.5 0.0 2.6 2 0 0 2 2 2 0 Glycosyl transferases group 1 MIF4G PF02854.14 CDI79921.1 - 1.1e-25 90.2 0.9 1.6e-25 89.8 0.6 1.2 1 0 0 1 1 1 1 MIF4G domain FadA PF09403.5 CDI79921.1 - 1.9 8.4 7.4 0.26 11.3 0.9 2.6 3 1 0 3 3 3 0 Adhesion protein FadA Transketolase_C PF02780.15 CDI79922.1 - 1.9e-37 127.9 0.4 2.7e-37 127.4 0.3 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.19 CDI79922.1 - 1.8e-26 92.7 0.0 3e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain TLD PF07534.11 CDI79923.1 - 6.5e-22 78.0 0.1 1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.13 CDI79923.1 - 7.9e-06 25.4 0.1 7.9e-06 25.4 0.1 3.1 4 0 0 4 4 4 1 Rab-GTPase-TBC domain Mod_r PF07200.8 CDI79928.1 - 6.7 6.6 13.6 0.52 10.2 2.3 3.1 2 2 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein AAA_23 PF13476.1 CDI79930.1 - 0.07 13.4 15.4 0.49 10.7 4.9 2.3 2 0 0 2 2 2 0 AAA domain Neur_chan_memb PF02932.11 CDI79930.1 - 0.16 11.8 16.4 0.19 11.5 0.0 3.2 3 1 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.9 CDI79930.1 - 0.91 7.4 22.1 0.86 7.5 1.8 2.3 2 0 0 2 2 2 0 CDC45-like protein Ycf1 PF05758.7 CDI79930.1 - 1.5 6.3 14.7 0.088 10.5 4.4 2.0 2 0 0 2 2 2 0 Ycf1 FAM176 PF14851.1 CDI79930.1 - 1.7 8.3 16.3 0.47 10.1 4.9 2.8 2 0 0 2 2 2 0 FAM176 family DUF1510 PF07423.6 CDI79930.1 - 2.3 7.5 25.4 1.8 7.8 9.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) SAPS PF04499.10 CDI79930.1 - 2.7 6.5 16.8 0.024 13.2 0.5 2.5 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein Tim54 PF11711.3 CDI79930.1 - 6.7 5.1 11.3 0.26 9.8 1.6 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Prefoldin_2 PF01920.15 CDI79931.1 - 3.2e-20 71.8 1.9 4.3e-20 71.4 1.3 1.2 1 0 0 1 1 1 1 Prefoldin subunit TMF_DNA_bd PF12329.3 CDI79931.1 - 0.00072 19.3 5.8 0.012 15.4 0.9 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.12 CDI79931.1 - 0.0028 17.2 1.7 0.3 10.7 0.0 2.2 2 0 0 2 2 2 1 Prefoldin subunit Filament PF00038.16 CDI79931.1 - 0.0063 16.0 2.8 0.096 12.1 0.1 2.1 2 0 0 2 2 2 1 Intermediate filament protein DUF3166 PF11365.3 CDI79931.1 - 0.011 16.1 3.5 0.14 12.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3166) Fib_alpha PF08702.5 CDI79931.1 - 0.012 15.7 0.4 2.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family EzrA PF06160.7 CDI79931.1 - 0.015 13.5 1.6 0.029 12.5 1.1 1.4 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA TMF_TATA_bd PF12325.3 CDI79931.1 - 0.017 14.8 0.9 0.66 9.7 0.1 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding GAS PF13851.1 CDI79931.1 - 0.021 14.0 1.2 0.87 8.7 0.3 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2802 PF10975.3 CDI79931.1 - 0.026 14.2 3.6 2.7 7.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) DUF615 PF04751.9 CDI79931.1 - 0.035 13.7 4.1 0.05 13.2 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF615) DUF3158 PF11358.3 CDI79931.1 - 0.04 13.4 1.3 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3158) DUF3869 PF12985.2 CDI79931.1 - 0.058 13.8 0.8 0.086 13.2 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3869) NYD-SP28 PF14772.1 CDI79931.1 - 0.06 13.4 0.1 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Sperm tail DASH_Dad3 PF08656.5 CDI79931.1 - 0.066 12.9 3.6 0.2 11.3 1.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 Seryl_tRNA_N PF02403.17 CDI79931.1 - 0.066 13.2 2.4 3.6 7.6 0.1 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1319 PF07028.6 CDI79931.1 - 0.086 13.0 3.7 2.2 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) DUF4140 PF13600.1 CDI79931.1 - 0.11 12.9 8.5 1 9.8 0.5 2.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Cob_adeno_trans PF01923.13 CDI79931.1 - 0.15 11.7 2.1 0.47 10.2 0.2 1.9 2 0 0 2 2 2 0 Cobalamin adenosyltransferase COG2 PF06148.6 CDI79931.1 - 0.17 11.7 2.3 0.36 10.6 0.1 2.0 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6 PF04111.7 CDI79931.1 - 0.19 10.7 5.2 0.89 8.5 0.4 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 Cortex-I_coil PF09304.5 CDI79931.1 - 0.22 11.5 3.7 2.5 8.1 0.5 2.2 2 0 0 2 2 2 0 Cortexillin I, coiled coil DUF4600 PF15372.1 CDI79931.1 - 0.26 11.5 2.6 2.7 8.2 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DUF3138 PF11336.3 CDI79931.1 - 0.26 9.4 9.8 0.025 12.7 4.0 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Spc24 PF08286.6 CDI79931.1 - 0.26 10.9 1.7 9.4 5.9 0.2 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF1664 PF07889.7 CDI79931.1 - 0.39 10.5 2.4 2.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 CDI79931.1 - 0.5 9.9 10.4 5.5 6.5 0.5 2.0 1 1 0 1 1 1 0 IncA protein DivIC PF04977.10 CDI79931.1 - 0.76 9.2 6.5 2.8 7.4 0.9 2.4 2 0 0 2 2 2 0 Septum formation initiator AATF-Che1 PF13339.1 CDI79931.1 - 0.81 9.8 6.9 5.5 7.1 0.5 2.1 1 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Cep57_CLD PF14073.1 CDI79931.1 - 0.88 9.3 6.2 2.2 8.0 4.3 1.6 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 CASP_C PF08172.7 CDI79931.1 - 1.1 8.2 7.0 7.2 5.5 0.1 2.1 2 0 0 2 2 2 0 CASP C terminal Mnd1 PF03962.10 CDI79931.1 - 1.3 8.6 5.4 4.8 6.8 3.8 1.7 1 1 0 1 1 1 0 Mnd1 family FliJ PF02050.11 CDI79931.1 - 1.8 8.6 9.4 1.7 8.7 0.4 2.3 3 0 0 3 3 2 0 Flagellar FliJ protein HAUS-augmin3 PF14932.1 CDI79931.1 - 2.1 7.4 5.3 11 5.0 3.6 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 FlxA PF14282.1 CDI79931.1 - 2.2 8.2 8.4 6.9 6.6 2.0 2.4 2 1 0 2 2 2 0 FlxA-like protein NTR2 PF15458.1 CDI79931.1 - 2.2 7.4 6.0 1.3 8.2 0.8 2.0 2 0 0 2 2 2 0 Nineteen complex-related protein 2 ADIP PF11559.3 CDI79931.1 - 8.5 6.2 8.6 12 5.7 1.4 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Vac14_Fab1_bd PF12755.2 CDI79932.1 - 3.3e-08 33.7 0.1 2.2e-05 24.7 0.0 3.9 3 1 2 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CDI79932.1 - 9.2e-06 25.9 3.1 0.0047 17.3 0.0 11.0 7 4 5 12 12 12 3 HEAT-like repeat HEAT PF02985.17 CDI79932.1 - 6.6e-05 22.6 25.0 8.9e-05 22.2 0.1 9.1 10 0 0 10 10 10 1 HEAT repeat Cnd1 PF12717.2 CDI79932.1 - 0.014 15.2 0.1 0.17 11.7 0.0 2.8 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 CDI79932.1 - 0.14 11.4 15.2 0.62 9.3 0.0 4.6 5 0 0 5 5 5 0 CLASP N terminal LMBR1 PF04791.11 CDI79934.1 - 0.2 10.1 21.3 0.098 11.2 4.2 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein Trehalose_PPase PF02358.11 CDI79935.1 - 1e-27 96.5 0.0 6.9e-16 57.8 0.0 2.7 1 1 1 2 2 2 2 Trehalose-phosphatase Hydrolase_3 PF08282.7 CDI79935.1 - 0.016 14.8 0.1 0.38 10.2 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Alba PF01918.16 CDI79935.1 - 0.087 12.4 0.0 0.48 10.0 0.0 2.1 2 0 0 2 2 2 0 Alba DUF2868 PF11067.3 CDI79935.1 - 0.4 9.7 15.9 4.1 6.4 9.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) zf-CCCH PF00642.19 CDI79936.1 - 4.2e-06 26.3 4.3 8.7e-06 25.2 3.0 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Utp14 PF04615.8 CDI79937.1 - 0.078 11.1 30.7 0.087 10.9 21.3 1.0 1 0 0 1 1 1 0 Utp14 protein PAT1 PF09770.4 CDI79937.1 - 0.19 9.9 67.4 0.22 9.7 46.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cwf_Cwc_15 PF04889.7 CDI79937.1 - 0.28 10.8 25.3 0.45 10.1 17.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GAGA_bind PF06217.7 CDI79937.1 - 0.3 11.0 23.1 0.35 10.7 16.0 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Med15 PF09606.5 CDI79937.1 - 0.38 8.8 78.5 0.4 8.8 54.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Nha1_C PF08619.5 CDI79937.1 - 0.52 9.5 24.9 0.58 9.3 17.3 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF605 PF04652.11 CDI79937.1 - 0.8 9.0 39.4 1 8.7 27.3 1.1 1 0 0 1 1 1 0 Vta1 like PLRV_ORF5 PF01690.12 CDI79937.1 - 1.2 8.2 26.0 1.3 8.0 18.0 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein FHIPEP PF00771.15 CDI79937.1 - 1.2 7.3 17.2 1.6 6.9 11.9 1.1 1 0 0 1 1 1 0 FHIPEP family DUF4045 PF13254.1 CDI79937.1 - 1.4 8.1 24.8 1.5 7.9 17.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MRP-S31 PF15433.1 CDI79937.1 - 1.6 8.0 26.2 1.9 7.8 18.2 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 FAM60A PF15396.1 CDI79937.1 - 2.4 7.8 19.2 3.7 7.2 13.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.7 CDI79937.1 - 3.6 6.1 30.0 4.6 5.7 20.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Draxin PF15550.1 CDI79937.1 - 3.7 7.0 20.0 4.6 6.8 13.9 1.1 1 0 0 1 1 1 0 Draxin Hid1 PF12722.2 CDI79937.1 - 5.3 4.6 27.2 5.8 4.4 18.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Vfa1 PF08432.5 CDI79937.1 - 5.3 7.0 27.6 8.1 6.4 19.1 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SAGA-Tad1 PF12767.2 CDI79937.1 - 5.5 6.5 32.8 7 6.2 22.8 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit FLO_LFY PF01698.11 CDI79937.1 - 6.6 5.4 25.0 8 5.1 17.4 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Dicty_REP PF05086.7 CDI79937.1 - 7.8 4.1 17.2 8.7 3.9 11.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Dapper PF15268.1 CDI79937.1 - 9 4.9 35.9 10 4.7 24.9 1.1 1 0 0 1 1 1 0 Dapper DUF966 PF06136.8 CDI79937.1 - 9.9 5.4 25.2 12 5.2 17.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) NTP_transf_2 PF01909.18 CDI79938.1 - 0.00061 20.0 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain K_channel_TID PF07941.6 CDI79938.1 - 0.015 15.4 0.3 0.015 15.4 0.2 4.9 3 1 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain PAP_assoc PF03828.14 CDI79938.1 - 0.032 14.1 0.1 0.067 13.1 0.1 1.6 1 0 0 1 1 1 0 Cid1 family poly A polymerase Serinc PF03348.10 CDI79938.1 - 0.11 11.1 0.6 0.16 10.6 0.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S49_N PF08496.5 CDI79938.1 - 0.54 10.0 4.9 1.1 9.0 3.4 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BRF1 PF07741.8 CDI79938.1 - 1.2 9.4 9.0 0.051 13.7 1.8 2.0 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Ribosomal_60s PF00428.14 CDI79938.1 - 8.6 6.8 43.7 3.7 8.0 2.4 4.4 4 0 0 4 4 4 0 60s Acidic ribosomal protein CLPTM1 PF05602.7 CDI79939.1 - 0.00033 19.4 0.1 0.031 13.0 0.0 2.1 2 0 0 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) AAA_23 PF13476.1 CDI79940.1 - 0.0052 17.1 4.2 0.0052 17.1 2.9 1.2 1 0 0 1 1 1 1 AAA domain PcfK PF14058.1 CDI79940.1 - 0.02 15.0 9.8 0.03 14.4 6.8 1.2 1 0 0 1 1 1 0 PcfK-like protein Corona_6B_7B PF03262.8 CDI79940.1 - 0.046 12.9 0.2 0.064 12.4 0.2 1.2 1 0 0 1 1 1 0 Coronavirus 6B/7B protein FAM60A PF15396.1 CDI79940.1 - 0.2 11.3 7.6 9 5.9 4.3 2.1 2 0 0 2 2 2 0 Protein Family FAM60A DUF853 PF05872.7 CDI79940.1 - 0.24 9.7 4.4 0.31 9.3 3.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Pox_Ag35 PF03286.9 CDI79940.1 - 0.26 10.8 8.0 0.41 10.1 5.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FYDLN_acid PF09538.5 CDI79940.1 - 0.39 11.3 8.1 4.3 7.9 4.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Vfa1 PF08432.5 CDI79940.1 - 0.43 10.5 13.6 0.6 10.0 9.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Hom_end_hint PF05203.11 CDI79940.1 - 0.56 9.9 6.3 0.79 9.4 4.4 1.2 1 0 0 1 1 1 0 Hom_end-associated Hint DUF4175 PF13779.1 CDI79940.1 - 1 6.9 21.8 1.3 6.6 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Anoctamin PF04547.7 CDI79940.1 - 1.9 7.0 6.3 2.4 6.7 4.4 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel DDRGK PF09756.4 CDI79940.1 - 2.1 7.7 18.0 3.3 7.0 12.5 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4557 PF15101.1 CDI79940.1 - 2.3 8.0 13.4 4.2 7.1 9.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DDHD PF02862.12 CDI79940.1 - 2.6 7.8 8.6 3.4 7.4 6.0 1.2 1 0 0 1 1 1 0 DDHD domain DUF2347 PF09804.4 CDI79940.1 - 3 7.0 7.8 4.7 6.4 5.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Peptidase_S49_N PF08496.5 CDI79940.1 - 3 7.6 9.0 4.2 7.1 6.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DNA_pol3_a_NII PF11490.3 CDI79940.1 - 3.4 7.3 18.1 5.7 6.5 12.5 1.4 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Borrelia_P83 PF05262.6 CDI79940.1 - 5 5.2 12.8 6.8 4.8 8.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4199 PF13858.1 CDI79940.1 - 5 7.0 4.7 7.6 6.4 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) EIIBC-GUT_N PF03612.9 CDI79940.1 - 6 6.4 8.6 9.1 5.8 5.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus OPA3 PF07047.7 CDI79940.1 - 6.9 6.4 10.4 14 5.4 7.2 1.5 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Band_3_cyto PF07565.8 CDI79940.1 - 7.7 5.9 9.9 11 5.4 6.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PBP1_TM PF14812.1 CDI79940.1 - 8.2 6.8 9.4 14 6.0 6.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2514 PF10721.4 CDI79940.1 - 8.4 6.0 17.7 2.6 7.7 10.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) CagX PF03524.10 CDI79940.1 - 9.5 5.4 9.3 15 4.7 6.4 1.2 1 0 0 1 1 1 0 Conjugal transfer protein LRR_6 PF13516.1 CDI79941.1 - 7.1e-05 22.4 0.3 1.7 8.9 0.5 3.8 2 1 1 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 CDI79941.1 - 8.5e-05 22.0 1.0 0.26 10.9 0.3 3.2 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CDI79941.1 - 0.029 14.3 0.1 4 7.8 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_8 PF13855.1 CDI79941.1 - 0.029 14.1 0.2 8 6.3 0.2 2.7 2 0 0 2 2 2 0 Leucine rich repeat LRR_7 PF13504.1 CDI79941.1 - 0.13 12.5 0.7 9.4 6.9 0.0 3.6 4 0 0 4 4 4 0 Leucine rich repeat DUF755 PF05501.6 CDI79941.1 - 0.2 11.7 18.6 0.36 10.8 12.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Activator_LAG-3 PF11498.3 CDI79941.1 - 5.8 5.5 22.4 8.2 5.0 15.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 zf-ZPR1 PF03367.8 CDI79943.1 - 2 7.5 5.7 1.6 7.8 0.1 3.0 3 0 0 3 3 3 0 ZPR1 zinc-finger domain SLS PF14611.1 CDI79943.1 - 2.6 7.4 10.8 0.031 13.7 1.1 2.4 3 0 0 3 3 3 0 Mitochondrial inner-membrane-bound regulator DUF218 PF02698.12 CDI79946.1 - 0.024 14.1 0.1 0.075 12.5 0.1 1.9 1 0 0 1 1 1 0 DUF218 domain SR-25 PF10500.4 CDI79946.1 - 0.43 10.0 9.2 0.22 10.9 4.6 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein LRR_4 PF12799.2 CDI79947.1 - 2.4e-15 55.7 4.8 1.4e-07 30.9 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI79947.1 - 1.7e-06 27.6 3.3 0.027 14.2 0.8 2.4 2 0 0 2 2 2 2 Leucine rich repeat LRR_9 PF14580.1 CDI79947.1 - 0.00044 19.8 0.2 0.00086 18.9 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.28 CDI79947.1 - 0.00077 19.1 1.2 4.5 7.6 0.0 4.3 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.1 CDI79947.1 - 0.0055 16.6 1.2 10 6.5 0.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeat LRR_7 PF13504.1 CDI79947.1 - 0.17 12.1 0.9 33 5.3 0.1 3.9 4 0 0 4 4 4 0 Leucine rich repeat Ycf1 PF05758.7 CDI79950.1 - 0.0013 16.6 15.6 0.0012 16.6 10.8 1.1 1 0 0 1 1 1 1 Ycf1 Med15 PF09606.5 CDI79950.1 - 0.005 15.1 69.7 0.0054 14.9 48.3 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI79950.1 - 0.061 11.5 57.9 0.07 11.3 40.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI79950.1 - 0.067 13.0 50.8 0.082 12.7 35.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.7 CDI79950.1 - 0.1 11.2 24.2 0.12 10.9 16.8 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SR-25 PF10500.4 CDI79950.1 - 0.16 11.3 30.0 0.29 10.5 20.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LicD PF04991.8 CDI79950.1 - 0.22 11.6 4.6 0.43 10.6 3.2 1.5 1 0 0 1 1 1 0 LicD family SAGA-Tad1 PF12767.2 CDI79950.1 - 0.38 10.3 26.7 0.55 9.8 18.5 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Paramyxo_ncap PF00973.14 CDI79950.1 - 0.42 9.2 21.8 0.52 8.9 15.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Mgr1 PF08602.5 CDI79950.1 - 0.42 9.5 12.8 0.6 9.0 8.9 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Draxin PF15550.1 CDI79950.1 - 0.45 10.1 22.0 0.68 9.5 15.3 1.3 1 0 0 1 1 1 0 Draxin BTV_NS2 PF04514.7 CDI79950.1 - 0.54 9.0 17.7 0.73 8.6 12.3 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 FHIPEP PF00771.15 CDI79950.1 - 1 7.6 15.6 1.4 7.1 10.8 1.2 1 0 0 1 1 1 0 FHIPEP family Peptidase_S64 PF08192.6 CDI79950.1 - 1.2 7.3 24.3 1.3 7.2 16.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 APG6 PF04111.7 CDI79950.1 - 1.6 7.7 31.3 2.5 7.0 21.7 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3584 PF12128.3 CDI79950.1 - 1.6 5.9 46.7 2 5.6 32.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4045 PF13254.1 CDI79950.1 - 1.8 7.7 26.7 2.9 7.0 18.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) FLO_LFY PF01698.11 CDI79950.1 - 2 7.1 27.1 3.5 6.3 18.8 1.4 1 0 0 1 1 1 0 Floricaula / Leafy protein Cellulose_synt PF03552.9 CDI79950.1 - 2.6 6.2 10.7 3.4 5.8 7.4 1.1 1 0 0 1 1 1 0 Cellulose synthase Gag_spuma PF03276.9 CDI79950.1 - 2.6 6.2 39.4 3.7 5.7 27.3 1.3 1 0 0 1 1 1 0 Spumavirus gag protein Exonuc_VII_L PF02601.10 CDI79950.1 - 2.7 7.0 26.3 3.6 6.7 18.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PLRV_ORF5 PF01690.12 CDI79950.1 - 2.7 7.0 25.2 3.6 6.6 17.5 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein SprA-related PF12118.3 CDI79950.1 - 2.8 7.1 69.3 4.3 6.5 48.1 1.3 1 0 0 1 1 1 0 SprA-related family CAF-1_p150 PF11600.3 CDI79950.1 - 3 7.1 49.2 0.047 13.0 27.1 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Hamartin PF04388.7 CDI79950.1 - 4.8 5.7 25.6 6.5 5.2 17.8 1.1 1 0 0 1 1 1 0 Hamartin protein Hid1 PF12722.2 CDI79950.1 - 4.9 4.6 27.6 6.5 4.2 19.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop53 PF07767.6 CDI79950.1 - 5.3 5.9 38.1 9.4 5.0 26.4 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PMSI1 PF15322.1 CDI79950.1 - 8 5.4 24.6 12 4.8 17.1 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative V_ATPase_I PF01496.14 CDI79950.1 - 8.3 4.1 15.8 9.2 3.9 11.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Kinesin PF00225.18 CDI79951.1 - 3.9e-79 265.7 7.5 3.9e-79 265.7 5.2 5.8 4 2 1 5 5 5 1 Kinesin motor domain UQ_con PF00179.21 CDI79952.1 - 0.00067 19.1 0.1 0.0019 17.6 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Plasmodium_Vir PF05795.6 CDI79952.1 - 0.015 14.5 0.6 0.015 14.5 0.4 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Mem_trans PF03547.13 CDI79952.1 - 0.058 11.6 0.6 0.25 9.5 0.0 2.1 2 0 0 2 2 2 0 Membrane transport protein AUX_IAA PF02309.11 CDI79952.1 - 0.35 10.5 6.5 0.14 11.8 0.3 2.2 2 0 0 2 2 2 0 AUX/IAA family DUF4306 PF14154.1 CDI79952.1 - 0.94 9.4 5.6 7.6 6.5 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4306) DUF1510 PF07423.6 CDI79952.1 - 2.8 7.2 13.1 0.63 9.3 4.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Neur_chan_memb PF02932.11 CDI79952.1 - 4.7 7.0 10.2 0.95 9.2 1.9 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region FAM176 PF14851.1 CDI79952.1 - 6.2 6.4 9.1 1.4 8.6 1.4 2.3 2 0 0 2 2 2 0 FAM176 family DUF566 PF04484.7 CDI79952.1 - 7.3 6.0 30.4 0.48 9.8 5.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF566) PAT1 PF09770.4 CDI79952.1 - 8.2 4.5 24.4 10 4.2 16.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LUC7 PF03194.10 CDI79953.1 - 8.2 5.8 10.2 0.35 10.3 0.7 2.1 2 0 0 2 2 2 0 LUC7 N_terminus Mito_carr PF00153.22 CDI79954.1 - 5.9e-31 106.0 4.6 1.7e-12 46.9 0.0 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Not3 PF04065.10 CDI79955.1 - 5.9e-46 156.6 7.2 5.9e-46 156.6 5.0 1.9 2 1 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 CDI79955.1 - 3.1e-29 101.5 0.4 3.1e-29 101.5 0.2 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Med3 PF11593.3 CDI79955.1 - 1.9e-06 27.4 1.2 1.9e-06 27.4 0.8 5.7 2 1 3 6 6 6 1 Mediator complex subunit 3 fungal 4HB_MCP_1 PF12729.2 CDI79955.1 - 0.4 10.0 7.4 0.039 13.3 1.7 1.8 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Pkinase PF00069.20 CDI79956.1 - 1.3e-05 24.4 1.3 3.2e-05 23.2 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79956.1 - 0.0033 16.5 0.1 0.0069 15.4 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4574 PF15141.1 CDI79957.1 - 0.14 11.8 0.3 0.14 11.8 0.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4574) CDC45 PF02724.9 CDI79957.1 - 0.46 8.4 31.1 0.53 8.2 21.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.8 CDI79957.1 - 3.9 5.5 36.9 4.7 5.2 25.6 1.0 1 0 0 1 1 1 0 Utp14 protein Daxx PF03344.10 CDI79957.1 - 5.7 5.3 33.3 6.7 5.0 23.1 1.0 1 0 0 1 1 1 0 Daxx Family Med15 PF09606.5 CDI79958.1 - 0.0017 16.6 21.2 0.0017 16.6 14.7 3.4 2 1 2 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal CAF-1_p150 PF11600.3 CDI79958.1 - 0.0065 15.8 8.8 0.0065 15.8 6.1 3.3 3 1 0 3 3 3 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal RED_N PF07808.8 CDI79958.1 - 0.42 9.7 12.3 2 7.5 4.5 2.5 2 0 0 2 2 2 0 RED-like protein N-terminal region Suf PF05843.9 CDI79958.1 - 0.6 9.7 14.9 0.33 10.6 7.2 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Dicty_REP PF05086.7 CDI79958.1 - 1.4 6.5 4.8 2.1 6.0 3.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SeqA PF03925.8 CDI79958.1 - 2.2 7.9 9.7 23 4.6 0.0 2.4 2 0 0 2 2 2 0 SeqA protein Spt20 PF12090.3 CDI79958.1 - 3.2 7.0 11.5 1.9 7.7 5.7 2.1 2 0 0 2 2 2 0 Spt20 family Proteasome PF00227.21 CDI79959.1 - 3.4e-19 68.8 0.0 5.1e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit DUF4279 PF14106.1 CDI79959.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) Ribosomal_60s PF00428.14 CDI79959.1 - 1.6 9.1 17.2 0.46 10.8 3.5 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein Corona_nucleoca PF00937.13 CDI79960.1 - 1 8.2 4.5 1.5 7.7 3.1 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Zip PF02535.17 CDI79961.1 - 0.00084 18.4 16.0 0.053 12.5 0.1 3.6 3 0 0 3 3 3 2 ZIP Zinc transporter SPX PF03105.14 CDI79961.1 - 0.009 15.8 0.2 0.009 15.8 0.2 3.9 3 1 0 3 3 3 1 SPX domain Sec62 PF03839.11 CDI79961.1 - 9.1 5.6 7.0 1.2 8.4 0.8 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 Activator_LAG-3 PF11498.3 CDI79962.1 - 0.00026 19.8 23.9 0.00026 19.8 16.6 3.7 4 0 0 4 4 4 1 Transcriptional activator LAG-3 Syja_N PF02383.13 CDI79963.1 - 1.7e-27 96.0 0.0 7.6e-20 70.9 0.2 5.7 5 1 1 6 6 6 4 SacI homology domain BTB PF00651.26 CDI79965.1 - 5.6e-13 48.8 0.0 7.9e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.1 CDI79965.1 - 4.5e-05 23.2 0.2 0.00068 19.5 0.1 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.1 CDI79965.1 - 0.00054 20.0 0.0 0.011 15.8 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.1 CDI79965.1 - 0.005 16.5 0.0 0.019 14.7 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 CDI79965.1 - 0.055 13.0 0.4 0.094 12.2 0.3 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.1 CDI79965.1 - 0.14 12.3 0.0 0.63 10.3 0.1 1.9 2 0 0 2 2 2 0 Kelch motif PIH1 PF08190.7 CDI79966.1 - 0.0048 16.3 0.0 0.0092 15.4 0.0 1.5 1 1 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Tricho_coat PF05892.6 CDI79966.1 - 0.065 12.4 0.0 0.08 12.1 0.0 1.1 1 0 0 1 1 1 0 Trichovirus coat protein V_ATPase_I PF01496.14 CDI79967.1 - 1.3e-128 429.9 4.5 8.7e-70 235.5 0.0 4.6 3 2 2 5 5 5 4 V-type ATPase 116kDa subunit family Spore_III_AB PF09548.5 CDI79967.1 - 0.069 12.8 0.1 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Rsc14 PF08586.5 CDI79968.1 - 0.039 14.4 1.7 0.062 13.7 1.2 1.3 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit FimP PF09766.4 CDI79968.1 - 0.21 10.6 5.1 0.28 10.1 3.5 1.2 1 0 0 1 1 1 0 Fms-interacting protein DUF4207 PF13904.1 CDI79968.1 - 9.9 5.4 19.1 16 4.7 13.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) Abhydrolase_6 PF12697.2 CDI79969.1 - 0.017 14.9 9.4 0.17 11.7 0.0 3.7 3 1 1 4 4 4 0 Alpha/beta hydrolase family PAT1 PF09770.4 CDI79970.1 - 0.00012 20.5 38.6 0.00013 20.4 26.7 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Zip PF02535.17 CDI79970.1 - 0.00012 21.1 0.1 0.00013 21.1 0.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter AAA_11 PF13086.1 CDI79970.1 - 0.00022 20.8 8.4 0.00026 20.6 5.8 1.3 1 0 0 1 1 1 1 AAA domain DDHD PF02862.12 CDI79970.1 - 0.00022 21.0 10.1 0.00032 20.5 7.0 1.3 1 0 0 1 1 1 1 DDHD domain CDC45 PF02724.9 CDI79970.1 - 0.0013 16.9 13.0 0.0014 16.8 9.0 1.1 1 0 0 1 1 1 1 CDC45-like protein TFIIA PF03153.8 CDI79970.1 - 0.0022 17.9 28.4 0.0024 17.8 19.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit GAGA_bind PF06217.7 CDI79970.1 - 0.0054 16.7 14.1 0.0082 16.1 9.8 1.3 1 0 0 1 1 1 1 GAGA binding protein-like family Presenilin PF01080.12 CDI79970.1 - 0.0063 15.3 4.9 0.0076 15.1 3.4 1.1 1 0 0 1 1 1 1 Presenilin Hid1 PF12722.2 CDI79970.1 - 0.0068 14.1 13.0 0.0069 14.1 9.0 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Band_3_cyto PF07565.8 CDI79970.1 - 0.008 15.7 15.9 0.011 15.2 11.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain DUF4045 PF13254.1 CDI79970.1 - 0.0081 15.4 10.8 0.0095 15.2 7.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4045) Nucleoside_tran PF01733.13 CDI79970.1 - 0.0085 15.2 1.8 0.012 14.7 1.3 1.3 1 0 0 1 1 1 1 Nucleoside transporter Ycf1 PF05758.7 CDI79970.1 - 0.024 12.3 15.6 0.027 12.2 10.8 1.0 1 0 0 1 1 1 0 Ycf1 SAPS PF04499.10 CDI79970.1 - 0.028 13.0 13.2 0.031 12.9 9.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AUX_IAA PF02309.11 CDI79970.1 - 0.034 13.8 11.5 0.042 13.5 7.9 1.3 1 0 0 1 1 1 0 AUX/IAA family RR_TM4-6 PF06459.7 CDI79970.1 - 0.059 13.2 16.8 0.088 12.6 11.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DHHW PF14286.1 CDI79970.1 - 0.065 12.5 10.7 0.083 12.2 7.4 1.1 1 0 0 1 1 1 0 DHHW protein Borrelia_P83 PF05262.6 CDI79970.1 - 0.072 11.3 20.4 0.073 11.3 14.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Kei1 PF08552.6 CDI79970.1 - 0.11 12.1 9.6 0.17 11.5 6.7 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DLH PF01738.13 CDI79970.1 - 0.11 11.7 9.5 0.42 9.8 6.5 1.8 1 1 1 2 2 2 0 Dienelactone hydrolase family DUF2370 PF10176.4 CDI79970.1 - 0.11 11.7 7.5 0.17 11.2 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SAGA-Tad1 PF12767.2 CDI79970.1 - 0.12 12.0 20.6 0.15 11.7 14.3 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Anoctamin PF04547.7 CDI79970.1 - 0.13 10.8 7.4 0.17 10.4 5.1 1.3 1 0 0 1 1 1 0 Calcium-activated chloride channel DUF2126 PF09899.4 CDI79970.1 - 0.14 10.1 10.3 0.17 9.9 7.1 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RP-C_C PF11800.3 CDI79970.1 - 0.19 11.4 14.9 0.28 10.8 10.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Gti1_Pac2 PF09729.4 CDI79970.1 - 0.19 11.5 11.0 0.3 10.9 7.6 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family SPX PF03105.14 CDI79970.1 - 0.21 11.3 16.8 0.23 11.1 11.7 1.1 1 0 0 1 1 1 0 SPX domain DUF605 PF04652.11 CDI79970.1 - 0.23 10.8 23.5 0.27 10.5 16.3 1.1 1 0 0 1 1 1 0 Vta1 like Glyco_transf_15 PF01793.11 CDI79970.1 - 0.24 10.3 14.1 0.29 10.0 9.8 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase LMBR1 PF04791.11 CDI79970.1 - 0.24 9.9 7.0 0.29 9.6 4.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein HCO3_cotransp PF00955.16 CDI79970.1 - 0.35 9.4 4.4 0.46 9.0 3.0 1.1 1 0 0 1 1 1 0 HCO3- transporter family ABC2_membrane_3 PF12698.2 CDI79970.1 - 0.38 9.7 1.5 0.43 9.5 1.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein FLO_LFY PF01698.11 CDI79970.1 - 0.43 9.3 17.6 0.58 8.9 12.2 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein AAA_23 PF13476.1 CDI79970.1 - 0.43 10.8 25.9 0.59 10.4 17.9 1.2 1 0 0 1 1 1 0 AAA domain Otopetrin PF03189.8 CDI79970.1 - 0.49 9.3 8.1 0.6 9.0 5.6 1.1 1 0 0 1 1 1 0 Otopetrin Plasmodium_Vir PF05795.6 CDI79970.1 - 0.5 9.5 4.8 0.58 9.3 3.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PIH1 PF08190.7 CDI79970.1 - 0.58 9.5 23.7 0.79 9.0 16.5 1.2 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 Phage_GPO PF05929.6 CDI79970.1 - 0.8 8.8 16.7 1 8.5 11.5 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FMN_dh PF01070.13 CDI79970.1 - 0.84 8.4 7.7 1 8.1 5.4 1.1 1 0 0 1 1 1 0 FMN-dependent dehydrogenase DUF822 PF05687.8 CDI79970.1 - 0.91 9.8 12.3 1.2 9.5 8.6 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF822) Cellulose_synt PF03552.9 CDI79970.1 - 0.95 7.6 8.0 1.1 7.5 5.5 1.1 1 0 0 1 1 1 0 Cellulose synthase CPSF100_C PF13299.1 CDI79970.1 - 1 9.5 17.6 1.6 8.8 12.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SeqA PF03925.8 CDI79970.1 - 1 8.9 15.6 1.4 8.5 10.8 1.3 1 0 0 1 1 1 0 SeqA protein DUF2561 PF10812.3 CDI79970.1 - 1.2 8.6 4.7 1.9 8.0 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Mem_trans PF03547.13 CDI79970.1 - 1.3 7.2 5.5 1.5 7.0 3.8 1.2 1 0 0 1 1 1 0 Membrane transport protein Peptidase_U57 PF05582.7 CDI79970.1 - 1.3 7.8 13.9 2 7.3 9.6 1.3 1 0 0 1 1 1 0 YabG peptidase U57 NARP1 PF12569.3 CDI79970.1 - 1.4 7.5 21.5 2 7.0 14.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 F-protein PF00469.15 CDI79970.1 - 1.5 8.1 16.7 2.1 7.6 11.6 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef eIF-3_zeta PF05091.7 CDI79970.1 - 1.7 7.1 26.8 2.3 6.7 18.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RNA_pol_Rpb1_5 PF04998.12 CDI79970.1 - 1.8 7.7 11.9 2.4 7.3 8.2 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF2201_N PF13203.1 CDI79970.1 - 1.8 7.6 23.5 2.3 7.3 15.1 1.8 2 0 0 2 2 2 0 Putative metallopeptidase domain DUF4220 PF13968.1 CDI79970.1 - 2 7.4 9.1 2.7 7.0 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF1800 PF08811.6 CDI79970.1 - 2.1 7.1 22.6 2.7 6.8 15.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) Dehalogenase PF13486.1 CDI79970.1 - 2.4 7.5 11.4 3 7.2 7.9 1.1 1 0 0 1 1 1 0 Reductive dehalogenase subunit Membralin PF09746.4 CDI79970.1 - 2.6 6.9 6.1 3 6.8 4.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Tim54 PF11711.3 CDI79970.1 - 2.7 6.5 14.8 4.5 5.7 10.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4638 PF15472.1 CDI79970.1 - 2.8 7.4 19.9 3.8 7.0 13.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Asp-B-Hydro_N PF05279.6 CDI79970.1 - 3.2 7.5 14.5 4.8 6.9 10.1 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region FemAB PF02388.11 CDI79970.1 - 3.3 6.3 20.9 4.4 5.8 14.5 1.1 1 0 0 1 1 1 0 FemAB family DUF912 PF06024.7 CDI79970.1 - 3.4 7.7 19.7 0.31 11.0 5.1 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Cyto_heme_lyase PF01265.12 CDI79970.1 - 3.8 7.0 20.9 5.3 6.5 14.5 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase Pal1 PF08316.6 CDI79970.1 - 4.2 7.8 11.5 7 7.1 8.0 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein Baculo_PP31 PF05311.6 CDI79970.1 - 4.5 6.4 22.4 0.36 10.0 12.5 1.4 2 0 0 2 2 1 0 Baculovirus 33KDa late protein (PP31) DUF1510 PF07423.6 CDI79970.1 - 6.4 6.0 26.1 1.7 7.9 16.1 1.4 2 0 0 2 2 1 0 Protein of unknown function (DUF1510) Paf1 PF03985.8 CDI79970.1 - 6.7 5.3 28.4 0.38 9.4 15.3 1.8 2 0 0 2 2 2 0 Paf1 HlyD_2 PF12700.2 CDI79970.1 - 6.8 5.7 17.7 8.8 5.3 12.3 1.2 1 0 0 1 1 1 0 HlyD family secretion protein DUF1501 PF07394.7 CDI79970.1 - 7.5 5.2 23.0 9.9 4.8 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Paramyxo_ncap PF00973.14 CDI79970.1 - 8.4 4.9 17.5 11 4.6 12.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Gag_spuma PF03276.9 CDI79970.1 - 9.4 4.4 41.0 13 4.0 28.4 1.2 1 0 0 1 1 1 0 Spumavirus gag protein AIF_C PF14721.1 CDI79970.1 - 9.8 6.4 18.3 3.4 7.9 10.6 1.8 2 0 0 2 2 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Rad54_N PF08658.5 CDI79971.1 - 0.048 13.4 0.3 0.078 12.7 0.2 1.5 1 0 0 1 1 1 0 Rad54 N terminal DUF3708 PF12501.3 CDI79971.1 - 1.4 8.6 7.0 2.6 7.8 4.9 1.5 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter Phosducin PF02114.11 CDI79971.1 - 1.5 7.4 7.3 1.8 7.2 5.0 1.1 1 0 0 1 1 1 0 Phosducin Exonuc_VII_L PF02601.10 CDI79971.1 - 3.3 6.8 14.0 3.8 6.5 9.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fumble PF03630.9 CDI79971.1 - 4.2 6.1 6.3 5.2 5.8 4.4 1.1 1 0 0 1 1 1 0 Fumble HlyD_2 PF12700.2 CDI79971.1 - 9.6 5.2 10.0 10 5.1 6.9 1.1 1 0 0 1 1 1 0 HlyD family secretion protein AP2 PF00847.15 CDI79972.1 - 0.0026 17.8 0.9 0.0026 17.8 0.6 4.8 4 0 0 4 4 4 2 AP2 domain Carb_kinase PF01256.12 CDI79974.1 - 9e-23 80.8 23.6 3.5e-17 62.5 0.0 5.6 5 1 1 6 6 6 3 Carbohydrate kinase Spt20 PF12090.3 CDI79974.1 - 0.39 10.0 2.9 17 4.7 0.1 3.3 4 0 0 4 4 4 0 Spt20 family Proteasome PF00227.21 CDI79975.1 - 2.3e-45 154.2 0.2 2.5e-39 134.5 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.4 CDI79975.1 - 4.7e-14 51.3 0.0 7.8e-14 50.6 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Pkinase PF00069.20 CDI79976.1 - 8.8e-41 139.7 0.0 8.8e-41 139.7 0.0 4.1 4 1 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI79976.1 - 1.9e-15 56.6 1.0 7.2e-08 31.8 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CDI79976.1 - 1.2 7.8 0.0 2 7.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PseudoU_synth_1 PF01416.15 CDI79979.1 - 3.5e-08 33.8 0.0 2e-07 31.4 0.0 2.2 1 1 0 1 1 1 1 tRNA pseudouridine synthase Mem_trans PF03547.13 CDI79979.1 - 0.86 7.8 5.0 0.98 7.6 1.5 2.0 2 0 0 2 2 2 0 Membrane transport protein Corona_nucleoca PF00937.13 CDI79979.1 - 2.4 7.0 34.7 2.7 6.8 8.1 2.4 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein Zn_peptidase PF04228.8 CDI79983.1 - 0.047 12.9 0.0 0.056 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Kinesin PF00225.18 CDI79984.1 - 9.9e-08 31.0 13.7 9.9e-08 31.0 9.5 3.2 1 1 1 2 2 2 1 Kinesin motor domain Mitofilin PF09731.4 CDI79984.1 - 0.032 12.9 54.8 0.038 12.6 38.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF2813 PF11398.3 CDI79984.1 - 0.35 9.8 24.5 0.46 9.4 17.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) SpoU_methylase PF00588.14 CDI79985.1 - 8.9e-17 61.2 0.0 5.3e-16 58.7 0.0 2.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoIIIAH PF12685.2 CDI79985.1 - 0.00031 20.3 7.8 0.00031 20.3 5.4 7.4 7 1 0 7 7 7 3 SpoIIIAH-like protein SprA-related PF12118.3 CDI79985.1 - 0.00054 19.3 30.4 0.00054 19.3 21.1 9.4 8 4 1 9 9 9 1 SprA-related family DUF3986 PF13143.1 CDI79988.1 - 0.11 12.9 0.5 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3986) Ycf1 PF05758.7 CDI79988.1 - 0.2 9.3 9.6 0.089 10.4 3.3 1.9 2 0 0 2 2 2 0 Ycf1 Spore_coat_CotO PF14153.1 CDI79988.1 - 0.73 9.2 24.0 0.23 10.8 8.4 2.4 2 0 0 2 2 2 0 Spore coat protein CotO DUF572 PF04502.8 CDI79988.1 - 0.96 8.6 22.7 0.1 11.7 8.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF572) DDHD PF02862.12 CDI79988.1 - 4.8 6.9 12.7 1.7 8.3 5.1 2.4 2 0 0 2 2 2 0 DDHD domain Dicty_REP PF05086.7 CDI79988.1 - 5.2 4.7 6.0 8 4.0 4.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Plasmodium_Vir PF05795.6 CDI79988.1 - 8.9 5.4 5.2 1.5 7.9 0.9 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF2453 PF10507.4 CDI79990.1 - 2.2e-15 56.4 3.9 2.2e-15 56.4 2.7 5.4 6 2 2 8 8 8 1 Protein of unknown function (DUF2453) Zip PF02535.17 CDI79991.1 - 2.7 6.9 9.9 14 4.5 0.1 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4512 PF14975.1 CDI79991.1 - 3.8 8.4 18.6 14 6.5 0.8 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4512) FAM176 PF14851.1 CDI79991.1 - 4.5 6.9 24.9 0.2 11.3 0.2 3.6 3 0 0 3 3 3 0 FAM176 family TPR_2 PF07719.12 CDI79993.1 - 0.0012 18.5 11.6 0.56 10.2 0.1 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat PAD_M PF08527.5 CDI79993.1 - 0.032 13.6 0.4 0.068 12.5 0.3 1.5 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain Plexin_cytopl PF08337.7 CDI79993.1 - 0.2 9.9 3.4 0.31 9.3 2.3 1.2 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain TPR_1 PF00515.23 CDI79993.1 - 0.23 11.1 3.6 1.8 8.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat SCF PF02404.10 CDI79993.1 - 5.6 6.0 6.0 0.75 8.9 0.0 2.2 2 0 0 2 2 2 0 Stem cell factor Med15 PF09606.5 CDI79994.1 - 0.0054 14.9 86.3 0.0072 14.5 59.8 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Parvo_coat PF00740.13 CDI79994.1 - 1.1 8.1 36.6 1.3 7.8 25.3 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP2 PAT1 PF09770.4 CDI79994.1 - 2 6.5 80.4 2.5 6.2 55.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SR-25 PF10500.4 CDI79994.1 - 2.2 7.7 68.3 0.028 13.8 32.5 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein CAF-1_p150 PF11600.3 CDI79994.1 - 3 7.1 56.3 4.9 6.4 39.0 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF605 PF04652.11 CDI79994.1 - 3.2 7.0 51.5 4.7 6.4 35.7 1.3 1 0 0 1 1 1 0 Vta1 like DUF4603 PF15376.1 CDI79994.1 - 7.4 3.6 30.8 8.4 3.4 21.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) F-box-like PF12937.2 CDI79995.1 - 1.5e-07 31.0 0.1 1.5e-07 31.0 0.1 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 CDI79995.1 - 0.00096 18.7 2.1 0.0014 18.2 0.1 2.3 2 0 0 2 2 2 1 F-box domain Med15 PF09606.5 CDI79995.1 - 0.0092 14.2 19.2 0.016 13.4 13.3 1.5 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Choline_kinase PF01633.15 CDI79997.1 - 1.1e-19 70.9 2.6 5.9e-13 48.8 0.0 2.7 3 0 0 3 3 3 2 Choline/ethanolamine kinase APH PF01636.18 CDI79997.1 - 6.1e-09 35.9 2.1 0.0013 18.5 0.5 2.8 3 0 0 3 3 3 2 Phosphotransferase enzyme family SGT1 PF07093.6 CDI79997.1 - 0.0013 17.2 7.4 0.1 10.9 2.5 2.0 2 0 0 2 2 2 2 SGT1 protein DUF4603 PF15376.1 CDI79997.1 - 0.0025 15.1 1.7 0.0025 15.1 1.2 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4603) Spt20 PF12090.3 CDI79997.1 - 0.022 14.1 6.1 0.31 10.3 0.4 2.2 2 0 0 2 2 2 0 Spt20 family Med15 PF09606.5 CDI79997.1 - 0.072 11.2 32.5 0.38 8.8 4.2 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 CDI79997.1 - 0.13 12.1 19.4 1.1 9.1 7.2 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.9 CDI79997.1 - 0.14 11.8 8.9 0.26 10.9 1.5 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Tim54 PF11711.3 CDI79997.1 - 0.3 9.6 6.0 0.36 9.3 0.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.11 CDI79997.1 - 0.34 10.7 7.3 3.4 7.4 0.1 2.5 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Otopetrin PF03189.8 CDI79997.1 - 0.61 9.0 2.1 14 4.5 0.3 2.1 2 0 0 2 2 2 0 Otopetrin FAM176 PF14851.1 CDI79997.1 - 1.7 8.2 11.6 4.9 6.8 2.0 2.5 2 0 0 2 2 2 0 FAM176 family BRF1 PF07741.8 CDI79997.1 - 3.5 7.9 16.6 9 6.5 2.7 2.7 2 0 0 2 2 2 0 Brf1-like TBP-binding domain PAT1 PF09770.4 CDI79997.1 - 8.5 4.4 31.6 2.2 6.3 2.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF3752 PF12572.3 CDI79999.1 - 2.4e-12 47.2 10.5 2.4e-12 47.2 7.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Actin PF00022.14 CDI80000.1 - 6.5e-68 228.9 0.0 2.3e-66 223.8 0.0 2.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CDI80000.1 - 0.79 8.2 2.8 14 4.2 0.0 2.8 3 0 0 3 3 3 0 MreB/Mbl protein Dynamitin PF04912.9 CDI80001.1 - 1.9e-32 112.5 6.2 2.7e-14 52.7 0.0 3.9 4 0 0 4 4 4 3 Dynamitin DUF972 PF06156.8 CDI80001.1 - 0.24 11.7 2.2 2 8.8 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF972) V_ATPase_I PF01496.14 CDI80001.1 - 0.44 8.3 3.1 0.31 8.8 0.7 1.5 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family Spectrin PF00435.16 CDI80001.1 - 0.9 9.8 8.8 3.4 7.9 0.6 2.8 2 0 0 2 2 2 0 Spectrin repeat PCRF PF03462.13 CDI80001.1 - 1.4 8.6 4.7 0.6 9.8 0.4 2.5 3 0 0 3 3 3 0 PCRF domain SlyX PF04102.7 CDI80001.1 - 3 8.3 14.4 20 5.6 0.3 4.3 4 0 0 4 4 4 0 SlyX DUF3138 PF11336.3 CDI80001.1 - 3.3 5.7 8.1 0.36 8.9 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3138) zf-C3HC4 PF00097.20 CDI80002.1 - 8.5e-07 28.5 8.4 8.5e-07 28.5 5.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI80002.1 - 6.6e-06 26.0 10.0 1.5e-05 24.9 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDI80002.1 - 9.5e-06 25.3 11.0 2.1e-05 24.2 7.7 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 CDI80002.1 - 5.6e-05 22.8 3.6 0.00011 21.9 2.5 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 CDI80002.1 - 0.00029 20.4 8.1 0.00094 18.8 5.7 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 CDI80002.1 - 0.00074 19.2 9.8 0.00074 19.2 6.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 CDI80002.1 - 0.0016 18.1 1.6 0.0034 17.0 1.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.1 CDI80002.1 - 0.0019 17.8 7.4 0.0019 17.8 5.2 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 CDI80002.1 - 0.0035 16.8 4.4 0.0072 15.8 3.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit CitT PF12431.3 CDI80002.1 - 0.063 13.3 0.1 1 9.4 0.0 2.6 2 0 0 2 2 2 0 Transcriptional regulator EcoR124_C PF12008.3 CDI80002.1 - 0.089 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal zf-Apc11 PF12861.2 CDI80002.1 - 0.093 12.5 2.9 0.19 11.5 2.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger EF-hand_like PF09279.6 CDI80002.1 - 0.12 12.4 1.9 0.23 11.5 0.3 2.2 3 0 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like zf-H2C2_2 PF13465.1 CDI80002.1 - 0.26 11.6 4.9 1.2 9.5 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double domain zf-RING_4 PF14570.1 CDI80002.1 - 0.85 9.2 13.2 5.1 6.7 9.4 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain LEA_6 PF10714.4 CDI80005.1 - 5.4 6.8 7.7 1.6 8.5 0.3 2.2 1 1 1 2 2 2 0 Late embryogenesis abundant protein 18 zf-RING_4 PF14570.1 CDI80006.1 - 4.4e-19 67.7 10.4 8.1e-19 66.9 7.2 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.17 CDI80006.1 - 1.7e-06 27.5 0.0 3.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80006.1 - 3e-05 23.7 0.0 6.5e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 CDI80006.1 - 0.00018 21.1 8.3 0.00018 21.1 5.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_6 PF14259.1 CDI80006.1 - 0.00071 19.4 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.1 CDI80006.1 - 0.024 14.3 3.5 0.066 12.9 2.4 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Baculo_IE-1 PF05290.6 CDI80006.1 - 0.14 11.8 3.3 0.28 10.9 2.3 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.1 CDI80006.1 - 0.45 10.5 11.2 0.92 9.5 7.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDI80006.1 - 3.2 7.7 12.0 4.7 7.1 7.3 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Radical_SAM PF04055.16 CDI80007.1 - 4.5e-18 65.9 0.0 1.5e-17 64.2 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily UPF0004 PF00919.15 CDI80007.1 - 1.3e-11 44.1 1.8 1.6e-05 24.6 0.6 3.5 2 1 1 3 3 3 2 Uncharacterized protein family UPF0004 Phg_2220_C PF09524.5 CDI80007.1 - 0.065 13.2 0.0 0.33 10.9 0.0 2.0 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) DUF788 PF05620.6 CDI80007.1 - 1 9.1 3.3 2.4 8.0 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF788) DUF3408 PF11888.3 CDI80007.1 - 9.7 6.1 9.9 9.2 6.1 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Mem_trans PF03547.13 CDI80009.1 - 1.6 6.9 5.1 3 6.0 3.5 1.4 1 0 0 1 1 1 0 Membrane transport protein Hid1 PF12722.2 CDI80009.1 - 2.3 5.7 17.8 0.016 12.9 6.1 1.8 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Ycf1 PF05758.7 CDI80009.1 - 3.7 5.1 19.7 0.066 10.9 8.9 1.5 2 0 0 2 2 2 0 Ycf1 RNA_pol_Rpb1_5 PF04998.12 CDI80009.1 - 8.8 5.4 10.5 14 4.7 6.1 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 5 ClpB_D2-small PF10431.4 CDI80010.1 - 2.2e-25 88.3 1.9 1.1e-24 86.0 1.3 2.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.15 CDI80010.1 - 1.5e-22 79.2 2.0 1.2e-13 50.7 0.0 2.8 2 0 0 2 2 2 2 Clp amino terminal domain AAA PF00004.24 CDI80010.1 - 6.2e-13 49.0 0.1 1.4e-05 25.2 0.0 3.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI80010.1 - 7.5e-12 45.6 10.4 8.2e-06 25.9 0.0 4.2 3 2 1 4 4 3 2 AAA ATPase domain AAA_18 PF13238.1 CDI80010.1 - 9.1e-10 38.9 0.2 5.5e-05 23.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.9 CDI80010.1 - 3.6e-09 36.7 0.6 0.0046 16.8 0.0 4.1 2 2 2 4 4 4 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CDI80010.1 - 1.6e-08 34.3 1.1 0.02 14.6 0.0 4.4 3 1 1 4 4 3 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 CDI80010.1 - 4.8e-08 32.6 0.0 0.01 15.2 0.0 3.6 3 0 0 3 3 3 2 IstB-like ATP binding protein Arch_ATPase PF01637.13 CDI80010.1 - 6.6e-08 32.5 0.4 0.059 13.0 0.1 3.6 2 1 1 3 3 3 2 Archaeal ATPase AAA_17 PF13207.1 CDI80010.1 - 1.6e-06 28.8 2.5 0.00055 20.7 0.0 3.7 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.1 CDI80010.1 - 1.2e-05 25.4 4.0 0.19 11.8 0.1 4.2 3 1 1 4 4 3 2 AAA domain NACHT PF05729.7 CDI80010.1 - 3.2e-05 23.6 0.0 0.39 10.3 0.0 3.5 3 0 0 3 3 3 2 NACHT domain RNA_helicase PF00910.17 CDI80010.1 - 7.5e-05 22.8 0.0 0.088 12.9 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_19 PF13245.1 CDI80010.1 - 0.00023 20.8 0.0 0.61 9.8 0.0 3.3 2 0 0 2 2 2 1 Part of AAA domain MobB PF03205.9 CDI80010.1 - 0.00068 19.3 0.0 0.37 10.4 0.0 2.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 CDI80010.1 - 0.00074 19.0 0.2 0.84 9.0 0.0 3.1 2 1 0 2 2 2 1 AAA-like domain Torsin PF06309.6 CDI80010.1 - 0.0011 18.9 0.0 0.0028 17.5 0.0 1.7 1 0 0 1 1 1 1 Torsin AAA_24 PF13479.1 CDI80010.1 - 0.0011 18.5 0.0 0.29 10.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 CDI80010.1 - 0.0015 18.5 0.4 2.5 8.0 0.0 3.7 3 1 0 3 3 3 1 AAA domain DUF258 PF03193.11 CDI80010.1 - 0.0017 17.5 0.0 2.2 7.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 UPF0079 PF02367.12 CDI80010.1 - 0.0018 17.9 0.3 2 8.0 0.1 3.1 3 1 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 NTPase_1 PF03266.10 CDI80010.1 - 0.0018 17.9 1.3 2.5 7.7 0.0 3.3 3 0 0 3 3 3 2 NTPase AAA_33 PF13671.1 CDI80010.1 - 0.0038 17.0 2.2 0.79 9.5 0.0 4.2 4 0 0 4 4 4 1 AAA domain Bac_DnaA PF00308.13 CDI80010.1 - 0.0066 16.1 0.0 0.18 11.4 0.0 2.5 2 0 0 2 2 2 1 Bacterial dnaA protein SRP54 PF00448.17 CDI80010.1 - 0.015 14.7 0.2 3.5 7.0 0.0 3.0 2 1 1 3 3 3 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.16 CDI80010.1 - 0.016 14.3 0.0 5.2 6.1 0.0 2.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 CDI80010.1 - 0.02 14.4 0.0 8.9 5.9 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.12 CDI80010.1 - 0.021 14.3 0.0 0.54 9.7 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 CDI80010.1 - 0.022 15.0 0.0 1 9.6 0.0 2.8 2 0 0 2 2 2 0 ABC transporter PduV-EutP PF10662.4 CDI80010.1 - 0.022 14.2 0.0 0.23 10.9 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 CDI80010.1 - 0.056 13.9 0.0 2 8.9 0.0 2.9 2 0 0 2 2 2 0 Miro-like protein MMR_HSR1 PF01926.18 CDI80010.1 - 0.16 11.9 0.0 23 4.9 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.1 CDI80010.1 - 1.7 8.9 0.0 1.7 8.9 0.0 3.6 3 1 0 3 3 2 0 AAA domain Lactamase_B PF00753.22 CDI80011.1 - 1.7e-11 44.1 0.0 4.5e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CDI80011.1 - 2.7e-10 40.1 0.0 3.4e-06 26.7 0.0 2.6 2 0 0 2 2 2 2 Beta-lactamase superfamily domain DUF4207 PF13904.1 CDI80011.1 - 0.0013 18.1 10.7 0.0024 17.2 7.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) ABC_tran_2 PF12848.2 CDI80011.1 - 0.68 9.8 14.2 0.1 12.4 6.4 2.1 2 0 0 2 2 2 0 ABC transporter Utp14 PF04615.8 CDI80012.1 - 6.3 4.8 29.5 10 4.1 20.4 1.2 1 0 0 1 1 1 0 Utp14 protein WD40 PF00400.27 CDI80013.1 - 6.2e-40 133.6 8.2 4.9e-08 32.5 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Hom_end_hint PF05203.11 CDI80013.1 - 0.022 14.5 1.3 0.039 13.6 0.9 1.5 1 0 0 1 1 1 0 Hom_end-associated Hint Herpes_UL87 PF03043.9 CDI80013.1 - 1.2 7.3 6.8 2.2 6.5 4.7 1.3 1 0 0 1 1 1 0 Herpesvirus UL87 family Peptidase_C6 PF00851.13 CDI80013.1 - 5 5.6 10.8 7.5 5.0 7.5 1.1 1 0 0 1 1 1 0 Helper component proteinase DUF1593 PF07632.6 CDI80015.1 - 0.12 11.6 1.0 0.21 10.8 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) MFS_1 PF07690.11 CDI80018.1 - 0.001 17.8 29.5 0.001 17.8 20.5 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily SOBP PF15279.1 CDI80018.1 - 5.2 7.3 52.4 1.7 8.9 18.9 3.3 3 0 0 3 3 3 0 Sine oculis-binding protein CAF-1_p150 PF11600.3 CDI80020.1 - 0.054 12.8 4.5 0.076 12.3 3.1 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Corona_nucleoca PF00937.13 CDI80020.1 - 0.34 9.7 12.5 0.46 9.3 8.7 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF3138 PF11336.3 CDI80020.1 - 1.3 7.1 16.2 1.7 6.7 11.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Rsm22 PF09243.5 CDI80021.1 - 5.6e-27 94.4 0.0 3.6e-16 59.0 0.0 2.4 1 1 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 MIP-T3 PF10243.4 CDI80023.1 - 0.00011 20.8 61.9 0.00016 20.2 42.9 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Dymeclin PF09742.4 CDI80024.1 - 1.5e-06 26.7 4.4 1.5e-06 26.7 3.1 4.2 3 2 0 3 3 3 2 Dyggve-Melchior-Clausen syndrome protein CDK2AP PF09806.4 CDI80024.1 - 0.0022 18.2 9.0 0.0022 18.2 6.2 10.1 5 2 1 6 6 6 1 Cyclin-dependent kinase 2-associated protein 7tm_1 PF00001.16 CDI80024.1 - 0.042 12.9 0.2 0.042 12.9 0.1 3.0 3 0 0 3 3 3 0 7 transmembrane receptor (rhodopsin family) GPCR_chapero_1 PF11904.3 CDI80024.1 - 8.9 5.3 22.1 0.4 9.7 2.5 3.7 3 0 0 3 3 3 0 GPCR-chaperone FERM_M PF00373.13 CDI80026.1 - 2.2 8.4 11.1 6.9 6.8 7.7 1.8 1 0 0 1 1 1 0 FERM central domain Cpn60_TCP1 PF00118.19 CDI80028.1 - 7.2e-75 252.4 10.2 6.3e-33 114.1 1.6 3.2 1 1 2 3 3 3 3 TCP-1/cpn60 chaperonin family Bax1-I PF01027.15 CDI80029.1 - 0.00049 19.7 0.2 0.00053 19.6 0.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Nucleoplasmin PF03066.10 CDI80033.1 - 0.05 13.1 1.6 0.097 12.1 1.1 1.4 1 0 0 1 1 1 0 Nucleoplasmin Pkinase PF00069.20 CDI80036.1 - 2e-60 204.1 0.0 2.3e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80036.1 - 5.3e-34 117.4 0.0 1e-33 116.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI80036.1 - 8.4e-06 25.6 0.0 0.022 14.4 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 CDI80036.1 - 0.0004 19.4 0.0 0.0011 17.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CDI80036.1 - 0.12 11.4 0.0 0.25 10.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_S8e PF01201.17 CDI80037.1 - 2.4e-35 121.5 15.2 1.9e-34 118.6 10.6 2.1 1 1 0 1 1 1 1 Ribosomal protein S8e TACC PF05010.9 CDI80038.1 - 0.28 10.9 11.0 0.027 14.2 4.3 1.8 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) NAM-associated PF14303.1 CDI80038.1 - 0.28 11.4 3.7 0.84 9.9 2.6 1.8 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DGF-1_C PF11040.3 CDI80038.1 - 0.4 10.5 2.8 3.7 7.5 0.0 3.5 4 0 0 4 4 4 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Cyclin_N PF00134.18 CDI80039.1 - 4.5e-11 42.4 0.5 1.4e-10 40.7 0.1 1.9 1 1 1 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 CDI80039.1 - 0.00017 21.4 0.0 0.0041 17.0 0.0 2.4 1 1 1 2 2 2 1 Cyclin, C-terminal domain BRCT PF00533.21 CDI80041.1 - 4.2e-06 26.8 0.0 1.3e-05 25.2 0.0 1.9 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain K_channel_TID PF07941.6 CDI80041.1 - 0.019 15.1 2.1 0.019 15.1 1.5 5.6 5 1 0 5 5 5 0 Potassium channel Kv1.4 tandem inactivation domain SR-25 PF10500.4 CDI80046.1 - 1.2 8.4 6.2 0.66 9.4 2.7 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RRP7 PF12923.2 CDI80047.1 - 0.0043 17.0 0.4 0.0043 17.0 0.3 1.6 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) RRM_1 PF00076.17 CDI80047.1 - 0.083 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med15 PF09606.5 CDI80048.1 - 0.0048 15.1 97.6 0.0054 15.0 67.6 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal MIP-T3 PF10243.4 CDI80048.1 - 0.014 13.9 58.0 0.018 13.5 40.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Daxx PF03344.10 CDI80048.1 - 0.92 7.9 51.1 1.1 7.6 35.4 1.0 1 0 0 1 1 1 0 Daxx Family PLRV_ORF5 PF01690.12 CDI80048.1 - 2.2 7.3 42.3 2.7 7.0 29.3 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein MOR2-PAG1_N PF14222.1 CDI80048.1 - 2.4 6.7 19.7 3.1 6.3 13.7 1.2 1 0 0 1 1 1 0 Cell morphogenesis N-terminal PP2C PF00481.16 CDI80051.1 - 1.2e-28 100.2 0.0 4.2e-27 95.1 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 CDI80051.1 - 0.0058 16.3 0.0 0.023 14.4 0.0 1.9 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PseudoU_synth_1 PF01416.15 CDI80052.1 - 6.8e-21 74.6 0.6 1.3e-08 35.2 0.2 4.2 2 1 0 2 2 2 2 tRNA pseudouridine synthase Rgp1 PF08737.5 CDI80053.1 - 0.00022 20.4 4.8 0.00022 20.4 3.4 4.4 4 1 1 5 5 5 2 Rgp1 DUF966 PF06136.8 CDI80053.1 - 0.00096 18.6 14.6 0.00096 18.6 10.2 3.8 2 1 2 4 4 4 1 Domain of unknown function (DUF966) SR-25 PF10500.4 CDI80053.1 - 0.0066 15.9 4.3 0.0066 15.9 3.0 6.6 6 1 2 8 8 8 1 Nuclear RNA-splicing-associated protein NIF PF03031.13 CDI80054.1 - 9.7e-23 80.5 0.0 5.2e-11 42.4 0.0 3.8 3 0 0 3 3 3 3 NLI interacting factor-like phosphatase Collagen PF01391.13 CDI80054.1 - 1.1e-08 34.4 34.2 0.00036 20.0 23.7 3.5 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) INCENP_ARK-bind PF03941.10 CDI80055.1 - 6.6e-05 22.6 0.1 6.6e-05 22.6 0.1 2.8 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region Spt20 PF12090.3 CDI80055.1 - 0.35 10.1 13.1 2.1 7.6 0.9 3.4 3 0 0 3 3 3 0 Spt20 family PCNA_N PF00705.13 CDI80056.1 - 1.9e-44 150.2 4.9 8.9e-44 148.0 1.7 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 CDI80056.1 - 8.2e-28 96.8 0.3 3.3e-27 94.9 0.1 2.1 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 CDI80056.1 - 1.1e-07 31.2 0.9 8.8e-07 28.2 0.7 2.0 1 1 0 1 1 1 1 Rad9 X PF00739.14 CDI80057.1 - 0.011 15.6 0.6 0.011 15.6 0.4 2.9 2 0 0 2 2 2 0 Trans-activation protein X AAA PF00004.24 CDI80058.1 - 5.2e-12 46.1 0.1 2.4e-07 31.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) APG9 PF04109.11 CDI80059.1 - 3.4e-09 36.0 0.0 3.4e-09 36.0 0.0 1.9 2 0 0 2 2 2 1 Autophagy protein Apg9 CAF1 PF04857.15 CDI80060.1 - 5.3e-65 219.3 0.1 7.6e-65 218.8 0.1 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Arm PF00514.18 CDI80061.1 - 1e-09 37.8 0.0 0.00048 19.8 0.0 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 CDI80061.1 - 5.4e-05 23.3 0.3 0.032 14.5 0.0 1.9 1 1 1 2 2 2 2 HEAT repeats WAPL PF07814.8 CDI80061.1 - 0.0085 14.8 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin DSPc PF00782.15 CDI80062.1 - 1.2e-06 28.1 0.4 4.5e-06 26.2 0.3 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 CDI80062.1 - 0.083 13.1 0.1 0.083 13.1 0.1 4.9 7 1 0 7 7 7 0 Tyrosine phosphatase family ACDC PF14733.1 CDI80063.1 - 1.6e-08 34.5 0.0 6.2e-08 32.6 0.0 2.0 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.15 CDI80063.1 - 0.00083 19.4 2.3 0.00083 19.4 1.6 3.4 4 0 0 4 4 4 1 AP2 domain DAG_kinase_N PF14513.1 CDI80064.1 - 0.062 13.4 0.1 0.062 13.4 0.1 2.3 2 1 0 2 2 2 0 Diacylglycerol kinase N-terminus RRM_6 PF14259.1 CDI80065.1 - 2.4e-19 69.0 0.0 5.1e-10 39.1 0.0 4.2 4 0 0 4 4 4 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI80065.1 - 6.4e-16 57.7 0.3 8.5e-08 31.7 0.0 4.5 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80065.1 - 3e-09 36.5 0.1 0.0018 18.0 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 CDI80065.1 - 0.03 12.8 85.4 0.033 12.6 46.7 2.2 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 YHYH PF14240.1 CDI80065.1 - 0.77 9.4 2.7 0.33 10.6 0.1 1.7 2 0 0 2 2 2 0 YHYH protein DnaJ-X PF14308.1 CDI80066.1 - 1.9e-54 184.0 5.2 1.9e-54 184.0 3.6 1.9 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 CDI80066.1 - 8.7e-28 95.8 2.5 1.9e-27 94.7 1.7 1.6 1 0 0 1 1 1 1 DnaJ domain Mem_trans PF03547.13 CDI80066.1 - 0.018 13.3 1.4 0.024 12.9 0.9 1.4 1 0 0 1 1 1 0 Membrane transport protein CytochromB561_N PF09786.4 CDI80066.1 - 3.4 6.0 20.9 5.6 5.2 14.5 1.3 1 0 0 1 1 1 0 Cytochrome B561, N terminal Lin-8 PF03353.10 CDI80066.1 - 8.7 5.5 12.2 2.6 7.2 5.6 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Herpes_UL52 PF03121.10 CDI80070.1 - 5.9e-05 22.7 0.0 0.00017 21.2 0.0 1.8 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase SAGA-Tad1 PF12767.2 CDI80070.1 - 0.0012 18.5 13.8 0.0012 18.5 9.6 6.3 3 2 0 5 5 5 1 Transcriptional regulator of RNA polII, SAGA, subunit SPX PF03105.14 CDI80070.1 - 0.0018 18.0 11.4 0.0018 18.0 7.9 5.5 3 2 1 5 5 5 1 SPX domain DUF4064 PF13273.1 CDI80071.1 - 1.4 9.0 4.8 12 6.0 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) T_Ag_DNA_bind PF02217.11 CDI80073.1 - 3.7 8.0 4.8 1.5 9.2 0.7 2.3 2 1 0 2 2 2 0 Origin of replication binding protein zf-HIT PF04438.11 CDI80074.1 - 4e-08 32.7 10.4 8.9e-08 31.6 7.2 1.6 1 0 0 1 1 1 1 HIT zinc finger CDC45 PF02724.9 CDI80074.1 - 0.24 9.3 17.3 0.56 8.1 12.0 1.5 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.2 CDI80074.1 - 0.62 7.6 17.6 0.3 8.7 7.2 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Paf1 PF03985.8 CDI80074.1 - 2.3 6.8 21.7 4.4 5.9 15.0 1.4 1 0 0 1 1 1 0 Paf1 Utp11 PF03998.8 CDI80074.1 - 3 7.6 28.1 3.8 7.2 1.7 2.2 2 0 0 2 2 2 0 Utp11 protein DUF2215 PF10225.4 CDI80074.1 - 4.7 6.5 13.0 2.5 7.4 4.9 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) SAPS PF04499.10 CDI80074.1 - 5 5.6 12.8 0.04 12.5 2.0 1.9 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF572 PF04502.8 CDI80074.1 - 6.5 5.8 30.1 0.46 9.6 11.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) zf-NADH-PPase PF09297.6 CDI80074.1 - 6.7 6.3 7.8 7.7 6.1 0.3 3.1 2 1 1 3 3 3 0 NADH pyrophosphatase zinc ribbon domain Rad60-SLD_2 PF13881.1 CDI80075.1 - 1.5e-07 31.2 0.1 1.5e-07 31.2 0.1 5.5 4 2 1 5 5 5 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.3 CDI80075.1 - 8.9e-06 25.3 5.1 9.3e-05 22.0 0.0 3.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF1378 PF07125.6 CDI80075.1 - 0.37 10.7 2.0 2.1 8.3 1.4 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1378) RAP1 PF07218.6 CDI80075.1 - 3.6 5.5 5.0 5.3 5.0 3.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3844 PF12955.2 CDI80076.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) CPSase_L_D2 PF02786.12 CDI80080.1 - 3.1e-50 170.4 0.0 6.7e-50 169.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 CDI80080.1 - 8.2e-25 87.0 0.0 2.5e-24 85.4 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Carboxyl_trans PF01039.17 CDI80080.1 - 1.3e-24 86.4 15.6 1e-18 67.0 1.9 3.7 2 1 1 3 3 3 2 Carboxyl transferase domain ACC_central PF08326.7 CDI80080.1 - 3.8e-21 74.9 9.6 1.2e-18 66.6 1.9 3.1 1 1 1 2 2 2 2 Acetyl-CoA carboxylase, central region Biotin_carb_C PF02785.14 CDI80080.1 - 6.2e-21 74.3 0.0 1.6e-20 73.0 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 CDI80080.1 - 3.3e-17 62.8 1.5 1.6e-15 57.3 0.0 3.3 3 0 0 3 3 3 1 ATP-grasp domain Biotin_lipoyl PF00364.17 CDI80080.1 - 3.7e-12 45.7 0.0 9.9e-12 44.3 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.17 CDI80080.1 - 6e-08 32.2 0.0 6e-08 32.2 0.0 3.2 3 0 0 3 3 3 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CDI80080.1 - 3e-07 30.0 0.0 6.7e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 CDI80080.1 - 0.0015 18.4 0.0 0.004 17.0 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain Chorein_N PF12624.2 CDI80082.1 - 2.6e-31 107.6 0.0 2.6e-31 107.6 0.0 3.3 3 0 0 3 3 3 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Zip PF02535.17 CDI80082.1 - 0.13 11.2 10.4 0.2 10.6 0.0 3.9 4 0 0 4 4 4 0 ZIP Zinc transporter DUF1091 PF06477.8 CDI80082.1 - 2.6 8.5 0.0 5.4 7.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) Ribosomal_L11_N PF03946.9 CDI80083.1 - 1.3e-16 59.7 0.0 1.9e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 CDI80083.1 - 4.2e-13 49.2 0.1 6.8e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain TM231 PF10149.4 CDI80083.1 - 0.02 13.9 0.0 0.024 13.6 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 231 Ribosomal_L30 PF00327.15 CDI80084.1 - 6.4e-16 57.6 0.3 1.3e-15 56.7 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 CDI80084.1 - 9.8e-13 47.9 18.4 2.2e-12 46.8 12.7 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain DUF4051 PF13260.1 CDI80084.1 - 0.97 8.8 4.8 0.54 9.6 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) Steroid_dh PF02544.11 CDI80085.1 - 1e-08 35.0 0.1 5.1e-06 26.3 0.0 3.3 3 0 0 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase Gastrin PF00918.12 CDI80085.1 - 0.11 13.3 4.5 0.19 12.5 0.1 2.6 3 0 0 3 3 3 0 Gastrin/cholecystokinin family Dehydrin PF00257.14 CDI80085.1 - 0.63 10.3 5.7 9 6.6 4.0 2.3 1 1 0 1 1 1 0 Dehydrin WBP-1 PF11669.3 CDI80085.1 - 2.3 8.3 10.6 0.11 12.5 1.5 2.5 1 1 1 2 2 2 0 WW domain-binding protein 1 SR-25 PF10500.4 CDI80085.1 - 2.6 7.4 11.3 0.13 11.7 3.8 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Gp_dh_C PF02800.15 CDI80086.1 - 0.17 11.3 0.3 0.29 10.5 0.2 1.3 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain WWE PF02825.15 CDI80087.1 - 1.1e-05 24.7 5.3 0.018 14.4 0.2 3.2 4 0 0 4 4 4 2 WWE domain zf-RING_2 PF13639.1 CDI80087.1 - 0.039 13.7 3.5 0.98 9.3 0.6 2.6 2 0 0 2 2 2 0 Ring finger domain Macoilin PF09726.4 CDI80087.1 - 5.1 5.2 15.6 11 4.1 10.8 1.5 1 0 0 1 1 1 0 Transmembrane protein Ribosomal_S19e PF01090.14 CDI80088.1 - 1.3e-49 167.1 0.0 1.5e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.5 CDI80088.1 - 0.0013 18.4 0.1 0.0029 17.3 0.0 1.6 2 0 0 2 2 2 1 Ribonuclease R winged-helix domain MarR_2 PF12802.2 CDI80088.1 - 0.12 12.0 0.0 0.6 9.8 0.0 2.1 3 0 0 3 3 3 0 MarR family Ldl_recept_a PF00057.13 CDI80088.1 - 0.2 11.5 0.6 0.31 10.9 0.4 1.3 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A AP_endonuc_2 PF01261.19 CDI80089.1 - 2.7e-28 98.7 0.0 4.3e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel HAD PF12710.2 CDI80090.1 - 0.0014 18.7 0.1 0.0027 17.8 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDI80090.1 - 0.0027 18.1 12.1 0.015 15.6 7.2 2.9 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase SAPS PF04499.10 CDI80090.1 - 0.0092 14.6 2.2 0.014 14.0 0.2 2.1 2 2 0 2 2 2 1 SIT4 phosphatase-associated protein Hydrolase_like2 PF13246.1 CDI80090.1 - 0.014 15.3 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 0 Putative hydrolase of sodium-potassium ATPase alpha subunit Ant_C PF05586.6 CDI80090.1 - 0.39 11.1 0.0 0.39 11.1 0.0 3.1 3 1 0 3 3 3 0 Anthrax receptor C-terminus region ABC2_membrane_2 PF12679.2 CDI80090.1 - 9.3 5.0 6.0 0.98 8.2 0.0 2.3 3 0 0 3 3 3 0 ABC-2 family transporter protein E1-E2_ATPase PF00122.15 CDI80091.1 - 1.8e-16 59.8 2.2 5.6e-15 55.0 0.0 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 CDI80091.1 - 0.0038 16.6 0.0 0.027 13.9 0.0 2.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus ResB PF05140.9 CDI80091.1 - 0.0039 15.7 0.8 0.0039 15.7 0.5 2.5 3 0 0 3 3 3 1 ResB-like family GRP PF07172.6 CDI80091.1 - 0.0077 16.6 2.9 1.5 9.3 0.0 3.3 3 0 0 3 3 3 1 Glycine rich protein family FAM176 PF14851.1 CDI80091.1 - 0.0078 15.9 9.1 0.3 10.7 0.0 3.7 4 0 0 4 4 4 1 FAM176 family SHR3_chaperone PF08229.6 CDI80091.1 - 0.0079 15.1 0.1 0.0079 15.1 0.1 4.0 4 0 0 4 4 4 1 ER membrane protein SH3 Chordopox_G3 PF06129.7 CDI80091.1 - 0.0091 16.1 1.1 1.9 8.6 0.0 3.3 3 0 0 3 3 3 1 Chordopoxvirus G3 protein Sex_peptide PF08138.6 CDI80091.1 - 0.033 14.0 0.9 0.26 11.1 0.2 2.6 2 0 0 2 2 2 0 Sex peptide (SP) family Spt20 PF12090.3 CDI80091.1 - 0.11 11.8 0.1 0.11 11.8 0.1 4.4 5 0 0 5 5 5 0 Spt20 family TMEM154 PF15102.1 CDI80091.1 - 0.14 11.8 0.0 0.14 11.8 0.0 3.7 4 0 0 4 4 3 0 TMEM154 protein family HAD PF12710.2 CDI80091.1 - 0.23 11.5 0.0 0.51 10.4 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PIG-P PF08510.7 CDI80091.1 - 0.98 9.0 2.3 8.3 6.0 0.0 3.3 4 0 0 4 4 4 0 PIG-P MLANA PF14991.1 CDI80091.1 - 1.1 9.3 0.0 1.1 9.3 0.0 2.8 4 0 0 4 4 2 0 Protein melan-A IncA PF04156.9 CDI80091.1 - 1.6 8.3 33.8 0.27 10.8 2.7 4.3 4 0 0 4 4 4 0 IncA protein YjgP_YjgQ PF03739.9 CDI80091.1 - 9.2 4.8 6.5 16 4.0 0.0 3.1 3 0 0 3 3 3 0 Predicted permease YjgP/YjgQ family PSK PF06404.7 CDI80092.1 - 1.1 10.1 6.2 7.3 7.4 0.8 2.4 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) YppG PF14179.1 CDI80092.1 - 1.1 9.9 20.7 1.8 9.1 14.3 1.3 1 0 0 1 1 1 0 YppG-like protein TFIIA PF03153.8 CDI80092.1 - 1.1 9.0 18.4 1.3 8.7 12.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AUX_IAA PF02309.11 CDI80092.1 - 1.9 8.1 6.0 2.5 7.7 4.2 1.1 1 0 0 1 1 1 0 AUX/IAA family Pex16 PF08610.5 CDI80092.1 - 2.2 7.1 8.0 3.1 6.6 5.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Hid1 PF12722.2 CDI80092.1 - 2.3 5.7 5.6 2.6 5.6 3.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Conotoxin PF02950.12 CDI80092.1 - 2.9 8.7 9.5 9.7 7.0 0.6 2.2 2 0 0 2 2 2 0 Conotoxin MAT1 PF06391.8 CDI80092.1 - 3.4 7.1 9.6 5 6.6 6.6 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Methyltransf_16 PF10294.4 CDI80098.1 - 1.1e-09 38.0 0.0 0.11 11.9 0.0 4.1 4 0 0 4 4 4 4 Putative methyltransferase PT PF04886.7 CDI80098.1 - 0.0048 16.1 7.7 0.0048 16.1 5.4 7.3 5 3 1 6 6 6 2 PT repeat Pkinase PF00069.20 CDI80099.1 - 2.9e-15 56.1 0.0 3.7e-11 42.6 0.0 5.1 5 2 1 6 6 6 2 Protein kinase domain RRM_1 PF00076.17 CDI80100.1 - 7.7e-06 25.4 0.0 2.4e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80100.1 - 5.9e-05 22.8 0.1 0.00083 19.1 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80100.1 - 0.002 18.0 0.1 0.023 14.6 0.0 2.7 2 1 1 3 3 3 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PRCH PF03967.8 CDI80100.1 - 0.074 12.6 0.5 0.19 11.2 0.4 1.6 1 0 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region Activator_LAG-3 PF11498.3 CDI80100.1 - 0.83 8.3 19.7 1.3 7.6 13.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF1180 PF06679.7 CDI80101.1 - 0.063 13.1 0.6 0.072 12.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) TFIIA PF03153.8 CDI80101.1 - 0.11 12.3 3.9 0.14 12.0 2.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit T2SM PF04612.7 CDI80101.1 - 0.32 10.7 11.7 0.6 9.8 8.1 1.6 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein M LPP20 PF02169.11 CDI80101.1 - 3.3 7.8 8.3 4.9 7.3 5.8 1.4 1 1 0 1 1 1 0 LPP20 lipoprotein Helicase_C PF00271.26 CDI80102.1 - 5.9e-18 64.5 0.0 5.9e-18 64.5 0.0 3.9 5 0 0 5 5 5 1 Helicase conserved C-terminal domain Macoilin PF09726.4 CDI80102.1 - 5.6e-05 21.6 36.4 5.6e-05 21.6 25.2 4.5 1 1 2 4 4 4 1 Transmembrane protein SR-25 PF10500.4 CDI80104.1 - 0.011 15.2 8.0 0.011 15.2 5.5 2.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Methyltransf_31 PF13847.1 CDI80105.1 - 8.1e-13 48.2 0.0 1.6e-12 47.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI80105.1 - 1.3e-09 38.6 0.1 2.3e-08 34.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 CDI80105.1 - 2.4e-09 36.7 0.0 3.3e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CDI80105.1 - 3e-09 36.9 0.0 5.9e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI80105.1 - 3.7e-09 36.9 0.1 1e-08 35.5 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 CDI80105.1 - 4.5e-05 22.8 0.1 8.5e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CDI80105.1 - 0.00022 20.9 0.0 0.00032 20.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI80105.1 - 0.0003 21.1 0.1 0.0012 19.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.6 CDI80105.1 - 0.0017 17.1 0.0 0.0027 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.7 CDI80105.1 - 0.023 15.1 0.0 0.054 13.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 CDI80105.1 - 0.037 13.4 0.1 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase DOT1 PF08123.8 CDI80105.1 - 0.052 12.8 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 PCMT PF01135.14 CDI80105.1 - 0.073 12.5 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 CDI80105.1 - 0.079 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.11 CDI80105.1 - 0.093 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Ras PF00071.17 CDI80106.1 - 1.6e-21 76.3 0.1 1.7e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI80106.1 - 9.6e-08 32.5 0.0 1.1e-07 32.3 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDI80106.1 - 4.2e-05 22.8 0.0 4.4e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family OATP PF03137.15 CDI80107.1 - 0.00024 19.3 0.0 0.00024 19.3 0.0 5.0 4 1 1 6 6 6 1 Organic Anion Transporter Polypeptide (OATP) family Shadoo PF14999.1 CDI80107.1 - 0.15 11.9 0.1 0.15 11.9 0.1 7.3 5 2 2 7 7 7 0 Shadow of prion protein, neuroprotective Claudin_2 PF13903.1 CDI80108.1 - 0.0074 15.9 0.4 0.0074 15.9 0.2 4.8 4 2 1 5 5 5 1 PMP-22/EMP/MP20/Claudin tight junction RRM_1 PF00076.17 CDI80109.1 - 6.6e-15 54.5 0.0 3.5e-08 32.9 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80109.1 - 9.4e-10 38.3 0.0 0.00013 21.8 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80109.1 - 8.9e-09 35.0 0.0 0.00039 20.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CDI80109.1 - 0.00035 20.2 0.0 0.16 11.7 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 APC_CDC26 PF10471.4 CDI80109.1 - 0.0068 17.1 7.7 0.015 16.0 5.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit 1 DUF2763 PF10961.3 CDI80109.1 - 0.16 12.4 2.9 0.31 11.4 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) RAB3GAP2_N PF14655.1 CDI80109.1 - 0.71 8.8 4.2 1.1 8.1 2.9 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ribosomal_L37ae PF01780.14 CDI80110.1 - 0.02 14.7 0.6 0.02 14.7 0.4 2.7 2 1 0 2 2 2 0 Ribosomal L37ae protein family TBCC PF07986.7 CDI80115.1 - 4.2e-15 55.2 0.1 1.2e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 Tubulin binding cofactor C Med15 PF09606.5 CDI80115.1 - 0.002 16.4 22.6 0.002 16.4 15.6 3.2 3 0 0 3 3 3 2 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI80115.1 - 0.0034 16.1 14.8 0.0034 16.1 10.3 3.8 4 0 0 4 4 4 2 Transcriptional activator LAG-3 Neur_chan_memb PF02932.11 CDI80115.1 - 0.018 14.9 6.3 0.028 14.2 0.0 2.6 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region zf-DHHC PF01529.15 CDI80115.1 - 0.6 9.4 5.7 7.9 5.8 0.0 3.1 3 0 0 3 3 3 0 DHHC palmitoyltransferase FAM176 PF14851.1 CDI80115.1 - 4.1 7.0 10.7 2 8.0 0.7 3.3 4 0 0 4 4 4 0 FAM176 family Ank_2 PF12796.2 CDI80116.1 - 2.1e-42 143.3 8.3 9.7e-22 77.1 0.4 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 CDI80116.1 - 1.8e-25 87.3 1.0 1.6e-10 40.2 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 CDI80116.1 - 1.6e-19 68.0 0.2 6.3e-07 29.0 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 CDI80116.1 - 7.3e-19 67.7 0.2 1.8e-09 37.8 0.0 4.2 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDI80116.1 - 1.5e-16 60.0 1.2 2.2e-08 34.0 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) zf-CCCH PF00642.19 CDI80117.1 - 3.1e-10 39.4 10.3 2.7e-09 36.4 4.4 3.0 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SR-25 PF10500.4 CDI80117.1 - 0.42 10.0 9.4 0.71 9.2 0.2 2.5 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.7 CDI80117.1 - 5.1 5.3 15.5 0.14 10.4 3.0 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CRM1_C PF08767.6 CDI80118.1 - 3.6e-29 101.7 0.1 3.6e-29 101.7 0.1 3.5 4 0 0 4 4 4 1 CRM1 C terminal IBN_N PF03810.14 CDI80118.1 - 9.1e-11 41.5 0.5 3.9e-10 39.4 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 CDI80118.1 - 5.6e-07 29.5 2.6 5.1e-06 26.4 0.3 3.4 3 1 0 3 3 3 1 Exportin 1-like protein Vac14_Fab1_bd PF12755.2 CDI80118.1 - 0.071 13.5 0.1 1.9 8.9 0.0 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Helicase_C PF00271.26 CDI80120.1 - 3.6e-23 81.1 1.9 3.9e-23 81.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GUCT PF08152.7 CDI80120.1 - 1.5e-06 28.1 0.0 0.00068 19.5 0.1 3.3 2 1 0 2 2 2 1 GUCT (NUC152) domain Ribosomal_60s PF00428.14 CDI80120.1 - 0.079 13.3 114.2 1 9.7 4.8 8.5 8 0 0 8 8 8 0 60s Acidic ribosomal protein SR-25 PF10500.4 CDI80121.1 - 3.6e-05 23.3 29.6 6.8e-05 22.4 20.5 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Daxx PF03344.10 CDI80121.1 - 0.00025 19.6 18.9 0.00025 19.6 13.1 1.1 1 0 0 1 1 1 1 Daxx Family Parvo_coat PF00740.13 CDI80121.1 - 0.02 13.8 18.9 0.02 13.8 13.1 1.2 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Ycf1 PF05758.7 CDI80121.1 - 0.027 12.2 19.5 0.032 11.9 13.5 1.2 1 0 0 1 1 1 0 Ycf1 DUF936 PF06075.7 CDI80121.1 - 0.073 11.9 18.5 0.12 11.2 12.8 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) SOBP PF15279.1 CDI80121.1 - 0.098 13.0 17.6 0.11 12.8 12.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Mem_trans PF03547.13 CDI80121.1 - 0.21 9.8 5.6 0.23 9.6 3.9 1.3 1 0 0 1 1 1 0 Membrane transport protein Utp14 PF04615.8 CDI80121.1 - 0.43 8.6 37.8 0.54 8.3 26.2 1.1 1 0 0 1 1 1 0 Utp14 protein SAPS PF04499.10 CDI80121.1 - 0.75 8.3 22.8 1.1 7.8 15.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PLRV_ORF5 PF01690.12 CDI80121.1 - 0.87 8.6 24.3 0.94 8.5 16.8 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Hid1 PF12722.2 CDI80121.1 - 0.96 7.0 26.1 1.1 6.8 18.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CRT10 PF08728.5 CDI80121.1 - 1 7.2 10.7 1.1 7.1 7.4 1.1 1 0 0 1 1 1 0 CRT10 DUF4045 PF13254.1 CDI80121.1 - 1.1 8.4 25.3 1.7 7.8 17.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) LMBR1 PF04791.11 CDI80121.1 - 1.2 7.6 11.3 1.1 7.7 7.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RNA_pol_Rpb1_5 PF04998.12 CDI80121.1 - 1.8 7.7 12.1 2.4 7.3 8.4 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 BTV_NS2 PF04514.7 CDI80121.1 - 2.8 6.7 25.6 3.6 6.3 17.7 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CAML PF14963.1 CDI80121.1 - 4.3 6.6 15.5 6.3 6.0 10.6 1.3 1 1 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand RR_TM4-6 PF06459.7 CDI80121.1 - 4.6 7.0 34.2 0.36 10.6 20.0 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF1266 PF06889.6 CDI80121.1 - 6.4 6.5 20.0 0.075 12.8 7.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1266) Raftlin PF15250.1 CDI80121.1 - 7.3 4.9 23.6 12 4.3 16.4 1.4 1 0 0 1 1 1 0 Raftlin Ndc1_Nup PF09531.5 CDI80121.1 - 9.6 4.4 21.3 11 4.2 14.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Dehydrin PF00257.14 CDI80122.1 - 0.026 14.8 0.3 0.026 14.8 0.2 20.4 15 3 3 18 18 18 0 Dehydrin Cupin_8 PF13621.1 CDI80123.1 - 2.9e-26 92.4 0.0 8.2e-25 87.7 0.0 2.7 1 1 0 1 1 1 1 Cupin-like domain AAA_23 PF13476.1 CDI80123.1 - 0.053 13.8 0.1 0.053 13.8 0.1 2.9 3 0 0 3 3 3 0 AAA domain IncA PF04156.9 CDI80123.1 - 7 6.2 24.2 0.14 11.6 6.0 3.6 4 0 0 4 4 4 0 IncA protein Allexi_40kDa PF05549.6 CDI80123.1 - 9.5 5.4 8.9 0.11 11.7 0.1 2.2 3 0 0 3 3 3 0 Allexivirus 40kDa protein Activator_LAG-3 PF11498.3 CDI80124.1 - 0.074 11.7 13.6 0.1 11.2 9.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SR-25 PF10500.4 CDI80126.1 - 1.7 8.0 29.9 0.36 10.2 10.5 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Acyl-CoA_dh_1 PF00441.19 CDI80126.1 - 3 7.9 8.7 1.1 9.4 0.2 2.6 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain zf-CCCH PF00642.19 CDI80127.1 - 0.0012 18.4 20.7 0.35 10.6 2.0 3.7 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF4414 PF14377.1 CDI80127.1 - 1.1 9.2 6.6 3.7 7.5 4.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) Codanin-1_C PF15296.1 CDI80127.1 - 1.2 8.9 8.0 13 5.6 5.5 2.3 1 1 0 1 1 1 0 Codanin-1 C-terminus FH2 PF02181.18 CDI80128.1 - 3.1e-68 230.3 0.3 4.3e-68 229.8 0.2 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Suc_Fer-like PF06999.7 CDI80131.1 - 0.86 9.5 8.9 0.96 9.4 6.2 1.0 1 0 0 1 1 1 0 Sucrase/ferredoxin-like Myco_19_kDa PF05481.7 CDI80131.1 - 1.3 8.8 7.3 1.5 8.6 5.1 1.1 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen DUF1908 PF08926.6 CDI80131.1 - 1.3 7.7 12.5 1.5 7.4 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) DUF3801 PF12687.2 CDI80131.1 - 2.3 7.7 17.2 2.5 7.6 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) SR-25 PF10500.4 CDI80131.1 - 2.7 7.3 35.2 9.3 5.6 24.4 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Activator_LAG-3 PF11498.3 CDI80131.1 - 2.9 6.5 44.7 3.2 6.4 31.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Med15 PF09606.5 CDI80131.1 - 5.1 5.1 44.0 4.9 5.2 30.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI80131.1 - 5.3 5.1 35.8 5.2 5.1 24.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CAF-1_p150 PF11600.3 CDI80131.1 - 5.9 6.1 25.8 7.6 5.8 17.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal YABBY PF04690.8 CDI80131.1 - 6.8 6.9 10.4 7.5 6.7 7.2 1.1 1 0 0 1 1 1 0 YABBY protein RAP1 PF07218.6 CDI80131.1 - 7.3 4.5 8.6 6.6 4.6 5.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AAA_23 PF13476.1 CDI80131.1 - 9.8 6.4 13.2 10 6.3 9.2 1.1 1 0 0 1 1 1 0 AAA domain SprA-related PF12118.3 CDI80131.1 - 9.9 5.3 35.8 12 5.0 24.8 1.1 1 0 0 1 1 1 0 SprA-related family DUF226 PF02890.9 CDI80133.1 - 0.044 13.5 0.0 0.16 11.6 0.0 2.0 1 0 0 1 1 1 0 Borrelia family of unknown function DUF226 RAB3GAP2_N PF14655.1 CDI80134.1 - 9.4e-22 77.5 14.5 8.1e-21 74.5 0.0 3.3 2 1 1 3 3 3 3 Rab3 GTPase-activating protein regulatory subunit N-terminus KAP_NTPase PF07693.9 CDI80134.1 - 0.12 11.2 0.0 0.35 9.8 0.0 1.8 1 1 1 2 2 2 0 KAP family P-loop domain NAD_binding_1 PF00175.16 CDI80135.1 - 1.3e-12 48.2 0.2 3.8e-05 24.1 0.0 3.3 2 1 1 3 3 3 2 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.20 CDI80135.1 - 0.0091 15.9 5.0 0.019 14.9 0.0 3.6 3 1 0 3 3 3 1 Flavodoxin Med15 PF09606.5 CDI80135.1 - 1 7.4 81.6 0.062 11.4 29.4 3.2 3 0 0 3 3 3 0 ARC105 or Med15 subunit of Mediator complex non-fungal PsaN PF05479.6 CDI80137.1 - 0.018 15.0 0.3 0.018 15.0 0.2 2.6 3 0 0 3 3 3 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Rotamase_2 PF13145.1 CDI80137.1 - 1.3 9.6 8.2 0.14 12.7 0.4 2.6 1 1 1 2 2 2 0 PPIC-type PPIASE domain DUF1840 PF08895.6 CDI80138.1 - 0.29 11.1 4.7 0.37 10.8 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF2076 PF09849.4 CDI80138.1 - 0.69 9.9 22.2 0.28 11.2 3.8 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Pox_A12 PF04651.8 CDI80138.1 - 1.3 9.0 8.1 0.086 12.9 1.4 1.9 2 0 0 2 2 2 0 Poxvirus A12 protein FAM176 PF14851.1 CDI80138.1 - 2.3 7.8 5.7 0.73 9.4 0.6 2.1 2 0 0 2 2 2 0 FAM176 family Caps_synth_GfcC PF06251.6 CDI80138.1 - 2.7 7.0 12.2 0.28 10.2 2.7 2.3 3 0 0 3 3 3 0 Capsule biosynthesis GfcC IncA PF04156.9 CDI80138.1 - 3.8 7.0 20.2 1.4 8.4 5.8 2.2 2 0 0 2 2 2 0 IncA protein DivIC PF04977.10 CDI80138.1 - 9 5.8 20.2 0.071 12.6 5.4 2.9 3 0 0 3 3 3 0 Septum formation initiator SRR1 PF07985.7 CDI80139.1 - 1.1e-13 50.8 1.4 2.1e-13 49.9 0.9 1.4 1 0 0 1 1 1 1 SRR1 Ribosomal_L38e PF01781.13 CDI80140.1 - 8.1e-28 95.9 0.5 1.1e-27 95.5 0.3 1.2 1 0 0 1 1 1 1 Ribosomal L38e protein family Succ_CoA_lig PF13607.1 CDI80140.1 - 0.0033 17.0 0.0 0.0048 16.5 0.0 1.2 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain DJ-1_PfpI PF01965.19 CDI80143.1 - 0.00026 20.4 0.0 0.00035 20.0 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Nol1_Nop2_Fmu PF01189.12 CDI80144.1 - 3.1e-10 39.9 1.0 5.9e-05 22.5 0.0 2.8 2 1 0 2 2 2 2 NOL1/NOP2/sun family PAT1 PF09770.4 CDI80144.1 - 0.055 11.7 16.0 0.12 10.5 11.1 1.5 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI80144.1 - 0.27 8.8 1.3 0.36 8.4 0.9 1.1 1 0 0 1 1 1 0 Ycf1 Neur_chan_memb PF02932.11 CDI80144.1 - 7.8 6.3 5.8 1.1 9.0 0.9 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GTP_EFTU PF00009.22 CDI80146.1 - 1.4e-54 184.4 0.0 2.9e-54 183.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 CDI80146.1 - 5.2e-29 99.8 0.0 1e-28 98.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 CDI80146.1 - 1.4e-26 92.3 0.0 3.5e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 CDI80146.1 - 5.5e-22 77.4 0.0 1.3e-21 76.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CDI80146.1 - 2.4e-12 46.7 0.1 6.9e-12 45.3 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 ECH PF00378.15 CDI80148.1 - 5.1e-26 91.3 0.5 3.3e-25 88.6 0.0 2.5 3 0 0 3 3 3 1 Enoyl-CoA hydratase/isomerase family MMR_HSR1 PF01926.18 CDI80148.1 - 1.2e-10 41.3 0.0 2.7e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDI80148.1 - 4.9e-09 35.8 0.0 6.9e-07 28.8 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ECH_C PF13766.1 CDI80148.1 - 1.8e-08 34.5 9.3 5.7e-08 32.9 0.5 4.1 3 1 1 4 4 4 1 2-enoyl-CoA Hydratase C-terminal region Miro PF08477.8 CDI80148.1 - 0.011 16.2 0.0 0.059 13.8 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein FeoB_N PF02421.13 CDI80148.1 - 0.012 14.9 1.1 0.47 9.7 0.0 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B DUF258 PF03193.11 CDI80148.1 - 0.029 13.5 0.0 0.085 12.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF190 PF02641.10 CDI80148.1 - 0.061 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 AAA_29 PF13555.1 CDI80148.1 - 0.064 12.8 0.2 0.14 11.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arch_ATPase PF01637.13 CDI80148.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase MobB PF03205.9 CDI80148.1 - 0.3 10.7 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Pro_isomerase PF00160.16 CDI80149.1 - 7.2e-48 162.7 0.1 7.2e-48 162.7 0.1 2.1 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.27 CDI80149.1 - 3e-11 42.7 1.7 0.024 14.5 0.0 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat Macoilin PF09726.4 CDI80149.1 - 5.6 5.1 47.0 11 4.1 32.6 1.4 1 0 0 1 1 1 0 Transmembrane protein DUF4131 PF13567.1 CDI80150.1 - 3.5 6.9 12.0 17 4.7 8.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) EMP24_GP25L PF01105.19 CDI80151.1 - 1.3e-21 77.1 0.1 1.6e-21 76.8 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2183 PF09949.4 CDI80152.1 - 0.0029 17.4 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Cyclin PF08613.6 CDI80154.1 - 1.6e-28 99.9 0.0 2.7e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CDI80154.1 - 6e-12 45.2 0.2 9.2e-12 44.6 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain NAD_Gly3P_dh_N PF01210.18 CDI80155.1 - 3.1e-40 137.4 0.0 5e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 CDI80155.1 - 3.5e-39 133.9 0.0 5.2e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus PfkB PF00294.19 CDI80157.1 - 8.6e-25 87.4 1.6 2e-19 69.8 0.2 2.4 1 1 0 2 2 2 2 pfkB family carbohydrate kinase Carb_kinase PF01256.12 CDI80157.1 - 0.019 14.2 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate kinase HEAT PF02985.17 CDI80158.1 - 0.0023 17.8 9.7 4.4 7.6 0.0 6.6 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 CDI80158.1 - 0.0036 17.5 25.4 0.3 11.3 0.3 6.6 5 3 2 7 7 7 5 HEAT repeats HECT PF00632.20 CDI80160.1 - 9.5e-35 120.2 0.0 2.6e-34 118.8 0.0 1.6 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank PF00023.25 CDI80160.1 - 4.8e-12 45.0 0.0 0.024 14.4 0.0 4.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 CDI80160.1 - 3.7e-10 39.9 0.0 3.6e-09 36.8 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI80160.1 - 6.8e-05 23.2 0.2 0.029 14.9 0.1 4.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI80160.1 - 0.0027 17.7 0.0 18 5.9 0.0 4.4 3 1 0 3 3 3 1 Ankyrin repeat Usp PF00582.21 CDI80161.1 - 0.03 14.5 2.2 0.041 14.0 1.5 1.3 1 0 0 1 1 1 0 Universal stress protein family PP2 PF14299.1 CDI80161.1 - 0.16 11.3 2.8 0.23 10.8 2.0 1.2 1 0 0 1 1 1 0 Phloem protein 2 Androgen_recep PF02166.11 CDI80161.1 - 0.17 10.7 18.1 0.2 10.4 12.6 1.1 1 0 0 1 1 1 0 Androgen receptor Ycf1 PF05758.7 CDI80161.1 - 0.19 9.4 13.1 0.18 9.4 9.1 1.1 1 0 0 1 1 1 0 Ycf1 DUF3371 PF11851.3 CDI80161.1 - 0.2 12.3 16.3 0.29 11.7 11.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) PAT1 PF09770.4 CDI80161.1 - 0.21 9.8 25.3 0.21 9.8 17.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI80161.1 - 0.24 9.5 35.7 0.27 9.3 24.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI80161.1 - 0.27 9.9 33.5 0.26 9.9 23.2 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PPP4R2 PF09184.6 CDI80161.1 - 0.43 10.0 15.9 0.44 10.0 11.1 1.1 1 0 0 1 1 1 0 PPP4R2 DDHD PF02862.12 CDI80161.1 - 0.6 9.8 13.6 0.75 9.5 9.4 1.2 1 0 0 1 1 1 0 DDHD domain Herpes_env PF01673.13 CDI80161.1 - 0.89 8.0 8.7 0.94 7.9 6.0 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Hid1 PF12722.2 CDI80161.1 - 1 6.9 17.7 1.1 6.8 12.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MMR1 PF08505.5 CDI80161.1 - 1.1 9.2 17.7 1.2 9.1 12.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Raftlin PF15250.1 CDI80161.1 - 2.2 6.7 16.9 2.3 6.6 11.7 1.0 1 0 0 1 1 1 0 Raftlin Herpes_DNAp_acc PF04929.7 CDI80161.1 - 3.1 6.6 16.2 3.6 6.4 11.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Mem_trans PF03547.13 CDI80161.1 - 3.3 5.8 5.9 3.2 5.9 4.1 1.1 1 0 0 1 1 1 0 Membrane transport protein RR_TM4-6 PF06459.7 CDI80161.1 - 3.6 7.4 18.2 5.2 6.8 12.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.1 CDI80161.1 - 4.2 7.0 16.4 4.9 6.8 11.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4175 PF13779.1 CDI80161.1 - 5.8 4.4 41.0 6 4.4 28.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.12 CDI80161.1 - 6.5 5.4 11.5 6.6 5.4 7.9 1.1 1 0 0 1 1 1 0 Presenilin DUF2201_N PF13203.1 CDI80161.1 - 7.5 5.6 19.2 8.7 5.4 13.3 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain BAF1_ABF1 PF04684.8 CDI80161.1 - 7.8 5.2 26.4 9 5.0 18.3 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FLO_LFY PF01698.11 CDI80161.1 - 9.6 4.9 17.1 11 4.6 11.8 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DXP_redisom_C PF08436.7 CDI80162.1 - 6.5e-34 115.6 0.0 1.3e-33 114.7 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal DXP_reductoisom PF02670.11 CDI80162.1 - 4.3e-29 101.6 3.7 4.3e-29 101.6 2.5 3.0 2 1 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.1 CDI80162.1 - 1.8e-12 47.2 0.0 1.8e-12 47.2 0.0 2.3 2 0 0 2 2 2 1 DXP reductoisomerase C-terminal domain Saccharop_dh PF03435.13 CDI80162.1 - 0.22 10.4 0.0 0.22 10.4 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase Ribosomal_L9_N PF01281.14 CDI80163.1 - 4.5e-11 41.8 0.0 7.8e-11 41.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain RIC3 PF15361.1 CDI80163.1 - 0.016 15.4 1.6 0.016 15.4 1.1 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 ORC5_C PF14630.1 CDI80163.1 - 0.035 13.5 0.2 0.035 13.5 0.1 2.3 3 0 0 3 3 3 0 Origin recognition complex (ORC) subunit 5 C-terminus HNOBA PF07701.9 CDI80163.1 - 0.74 8.9 8.0 0.15 11.2 0.1 2.6 3 0 0 3 3 3 0 Heme NO binding associated PP2 PF14299.1 CDI80163.1 - 1 8.7 4.3 1.9 7.8 0.0 2.6 3 0 0 3 3 3 0 Phloem protein 2 PAT1 PF09770.4 CDI80163.1 - 1 7.5 39.1 0.87 7.7 10.6 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF1764 PF08576.5 CDI80163.1 - 1.7 9.4 18.3 0.43 11.3 2.4 2.9 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Afi1 PF07792.7 CDI80163.1 - 2 8.3 11.4 5.8 6.9 3.1 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Baculo_PP31 PF05311.6 CDI80163.1 - 2 7.5 10.6 1.8 7.7 3.4 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) PA26 PF04636.8 CDI80163.1 - 2.1 6.9 7.3 0.33 9.6 1.7 1.8 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) FPN1 PF06963.7 CDI80163.1 - 4.2 5.6 7.7 0.36 9.1 1.2 1.9 2 0 0 2 2 2 0 Ferroportin1 (FPN1) zf-DHHC PF01529.15 CDI80163.1 - 4.5 6.6 0.0 4.5 6.6 0.0 2.7 2 1 0 2 2 1 0 DHHC palmitoyltransferase FHIPEP PF00771.15 CDI80163.1 - 6.3 4.9 10.8 5.8 5.1 2.1 2.3 2 1 0 2 2 2 0 FHIPEP family FAM176 PF14851.1 CDI80163.1 - 8.5 6.0 10.9 13 5.3 3.0 2.8 3 0 0 3 3 3 0 FAM176 family Peptidase_S49_N PF08496.5 CDI80163.1 - 8.8 6.1 10.6 0.67 9.7 1.1 2.7 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DUF3306 PF11748.3 CDI80163.1 - 8.8 7.0 16.6 4.4 7.9 3.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) DUF3449 PF11931.3 CDI80163.1 - 8.9 5.7 16.1 0.067 12.6 1.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3449) eIF_4EBP PF05456.6 CDI80163.1 - 9.3 5.9 9.5 2.5 7.8 0.3 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) FimP PF09766.4 CDI80164.1 - 3.1 6.7 33.3 4.4 6.2 23.1 1.3 1 0 0 1 1 1 0 Fms-interacting protein DUF4175 PF13779.1 CDI80164.1 - 5.8 4.4 56.4 6.8 4.2 39.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FAM176 PF14851.1 CDI80164.1 - 5.9 6.5 13.2 8.2 6.0 9.1 1.3 1 0 0 1 1 1 0 FAM176 family DUF4407 PF14362.1 CDI80164.1 - 6.7 5.5 30.0 7.1 5.4 20.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF966 PF06136.8 CDI80164.1 - 8.6 5.6 22.0 9.6 5.5 15.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SNF2_N PF00176.18 CDI80165.1 - 3.4e-46 157.3 0.0 3.4e-46 157.3 0.0 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain SR-25 PF10500.4 CDI80165.1 - 0.00049 19.6 6.4 0.00049 19.6 4.5 11.0 9 3 2 11 11 11 1 Nuclear RNA-splicing-associated protein Pex14_N PF04695.8 CDI80165.1 - 0.057 13.4 0.1 0.023 14.7 5.8 11.9 11 1 0 11 11 11 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HSP70 PF00012.15 CDI80166.1 - 7.8e-274 909.1 5.8 8.9e-274 909.0 4.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDI80166.1 - 4.2e-15 55.1 0.2 7.7e-13 47.7 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 CDI80166.1 - 0.00056 19.1 0.3 0.014 14.5 0.1 2.5 1 1 0 2 2 2 1 Hydantoinase/oxoprolinase FGGY_C PF02782.11 CDI80166.1 - 0.0017 18.0 0.0 0.01 15.4 0.0 2.1 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 CDI80166.1 - 0.0067 15.2 0.7 0.35 9.6 0.1 2.4 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain DDE_Tnp_ISL3 PF01610.12 CDI80167.1 - 2.3 7.7 6.1 0.33 10.5 1.1 1.9 2 0 0 2 2 2 0 Transposase LXG PF04740.7 CDI80169.1 - 0.0069 16.2 0.7 0.21 11.3 0.3 2.5 2 0 0 2 2 2 1 LXG domain of WXG superfamily Med28 PF11594.3 CDI80169.1 - 0.073 13.3 1.5 0.14 12.4 0.3 2.0 2 0 0 2 2 2 0 Mediator complex subunit 28 Syntaxin_2 PF14523.1 CDI80170.1 - 0.0023 17.9 3.7 0.17 11.8 0.0 3.9 3 1 1 4 4 4 2 Syntaxin-like protein Histone PF00125.19 CDI80171.1 - 5.9e-34 116.0 0.3 9.4e-34 115.3 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 CDI80171.1 - 4.9e-05 23.4 0.0 7.4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 CDI80171.1 - 0.015 15.3 0.1 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 CDI80171.1 - 0.052 13.3 0.2 0.098 12.4 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit DUF814 PF05670.8 CDI80172.1 - 1.1e-20 73.3 0.0 1.9e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF814) DUF853 PF05872.7 CDI80172.1 - 0.88 7.8 6.6 1.1 7.4 4.6 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Transformer PF06495.6 CDI80172.1 - 1 9.2 7.4 1.5 8.7 5.1 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein DUF2215 PF10225.4 CDI80172.1 - 7.3 5.9 9.7 8.1 5.8 6.6 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) tRNA-synt_1g PF09334.6 CDI80174.1 - 1.6e-23 83.0 15.8 4.4e-12 45.3 0.0 5.4 6 0 0 6 6 6 4 tRNA synthetases class I (M) PAT1 PF09770.4 CDI80174.1 - 0.085 11.0 73.5 0.0094 14.2 20.9 2.7 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PIG-P PF08510.7 CDI80174.1 - 0.21 11.1 0.9 2.4 7.8 0.1 2.8 2 0 0 2 2 2 0 PIG-P Sigma70_ner PF04546.8 CDI80176.1 - 0.0046 16.5 9.8 0.01 15.4 6.8 1.6 1 0 0 1 1 1 1 Sigma-70, non-essential region RP-C_C PF11800.3 CDI80176.1 - 0.017 14.8 3.0 0.024 14.3 2.1 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Mif2_N PF15624.1 CDI80176.1 - 0.029 14.9 9.3 0.64 10.6 3.9 2.4 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Nucleoside_tran PF01733.13 CDI80176.1 - 0.17 10.9 0.7 0.24 10.5 0.5 1.2 1 0 0 1 1 1 0 Nucleoside transporter POX PF07526.6 CDI80176.1 - 0.2 11.8 3.8 0.47 10.6 2.6 1.6 1 0 0 1 1 1 0 Associated with HOX Iron_permease PF04120.7 CDI80176.1 - 1.4 8.5 5.6 4 7.0 3.9 1.7 1 0 0 1 1 1 0 Low affinity iron permease AFT PF08731.6 CDI80177.1 - 0.19 11.9 10.9 0.23 11.6 7.6 1.2 1 0 0 1 1 1 0 Transcription factor AFT DUF3408 PF11888.3 CDI80177.1 - 3.9 7.4 21.6 4.9 7.0 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) GOLD_2 PF13897.1 CDI80177.1 - 4.5 7.5 8.6 5.3 7.2 6.0 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking FAM176 PF14851.1 CDI80177.1 - 7.2 6.2 12.2 9.3 5.9 8.4 1.3 1 0 0 1 1 1 0 FAM176 family zf-rbx1 PF12678.2 CDI80179.1 - 4.1e-32 110.1 10.0 5.8e-32 109.6 6.9 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CDI80179.1 - 9.9e-16 57.3 8.1 1.5e-15 56.8 5.6 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 CDI80179.1 - 0.00014 21.6 10.4 0.00096 18.9 7.2 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDI80179.1 - 0.011 15.3 9.8 0.11 12.1 6.8 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 CDI80179.1 - 0.09 12.7 6.9 0.58 10.1 5.1 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain SR-25 PF10500.4 CDI80179.1 - 0.18 11.2 14.9 0.23 10.9 10.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF508 PF04370.7 CDI80179.1 - 0.25 10.9 5.7 0.32 10.6 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF508) DUF4001 PF13165.1 CDI80179.1 - 0.28 10.8 5.1 0.68 9.6 3.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4001) zf-HC5HC2H_2 PF13832.1 CDI80179.1 - 0.75 9.8 9.4 1.6 8.7 6.5 1.6 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-C3HC4_4 PF15227.1 CDI80179.1 - 0.76 9.7 0.1 0.76 9.7 0.1 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DNA_pol_viral_N PF00242.12 CDI80179.1 - 0.99 8.3 4.8 1.2 8.1 3.3 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain zf-RING_UBOX PF13445.1 CDI80179.1 - 1.1 9.0 6.1 1.2 8.8 0.6 2.2 1 1 1 2 2 2 0 RING-type zinc-finger Med3 PF11593.3 CDI80179.1 - 1.5 8.0 5.5 1.8 7.7 3.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-HC5HC2H PF13771.1 CDI80179.1 - 1.8 8.7 10.2 64 3.7 7.1 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain Macoilin PF09726.4 CDI80179.1 - 2.1 6.5 4.5 2.3 6.3 3.1 1.0 1 0 0 1 1 1 0 Transmembrane protein zf-C3HC4_3 PF13920.1 CDI80179.1 - 2.2 7.9 8.3 17 5.1 0.1 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI80179.1 - 5.3 7.1 11.4 1.1e+02 2.9 8.0 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MSP1_C PF07462.6 CDI80179.1 - 6 5.1 6.3 7.1 4.8 4.4 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF1645 PF07816.6 CDI80179.1 - 6.3 7.2 12.4 8.9 6.7 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) YukD PF08817.5 CDI80180.1 - 0.3 11.6 2.2 6 7.5 0.3 2.5 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Herpes_env PF01673.13 CDI80180.1 - 0.45 9.0 21.4 0.55 8.7 14.8 1.0 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Daxx PF03344.10 CDI80180.1 - 0.46 8.9 36.2 0.59 8.5 25.1 1.0 1 0 0 1 1 1 0 Daxx Family PAT1 PF09770.4 CDI80180.1 - 0.57 8.3 68.3 0.67 8.1 47.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Utp14 PF04615.8 CDI80180.1 - 0.58 8.2 38.9 0.74 7.9 27.0 1.0 1 0 0 1 1 1 0 Utp14 protein DUF966 PF06136.8 CDI80180.1 - 0.94 8.8 24.9 1.2 8.5 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Hid1 PF12722.2 CDI80180.1 - 1.1 6.8 32.4 1.3 6.6 22.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ycf1 PF05758.7 CDI80180.1 - 3.5 5.2 30.4 4.8 4.7 21.1 1.2 1 0 0 1 1 1 0 Ycf1 TFIIA PF03153.8 CDI80180.1 - 3.8 7.3 53.2 5.3 6.8 36.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Vfa1 PF08432.5 CDI80180.1 - 3.9 7.4 36.6 5.1 7.0 25.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Macoilin PF09726.4 CDI80180.1 - 7.2 4.7 29.0 9.2 4.4 20.1 1.1 1 0 0 1 1 1 0 Transmembrane protein PLRV_ORF5 PF01690.12 CDI80180.1 - 8.8 5.3 30.1 11 5.0 20.9 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein JAB PF01398.16 CDI80182.1 - 3.9e-13 49.1 0.0 5.5e-11 42.2 0.0 2.5 2 0 0 2 2 2 2 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HMG_box_2 PF09011.5 CDI80182.1 - 0.046 14.0 1.9 17 5.8 0.1 3.3 2 2 0 2 2 2 0 HMG-box domain DUF4525 PF15027.1 CDI80182.1 - 0.1 12.1 0.3 0.29 10.6 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) AICARFT_IMPCHas PF01808.13 CDI80183.1 - 0.0062 15.6 1.9 0.0072 15.4 1.3 1.0 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme FliD_N PF02465.13 CDI80183.1 - 0.011 16.0 12.4 0.013 15.8 8.6 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus BAF1_ABF1 PF04684.8 CDI80183.1 - 0.052 12.3 17.8 0.061 12.1 12.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Med15 PF09606.5 CDI80183.1 - 0.11 10.7 25.9 0.12 10.5 17.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CLPTM1 PF05602.7 CDI80183.1 - 0.24 10.1 2.4 0.27 9.8 1.7 1.0 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF4192 PF13830.1 CDI80183.1 - 0.29 10.7 9.8 0.33 10.5 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) CTI PF06934.6 CDI80183.1 - 0.3 9.2 5.3 0.31 9.2 3.7 1.0 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) Peptidase_C58 PF03543.9 CDI80183.1 - 0.37 10.2 13.0 0.43 10.0 9.0 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen LCD1 PF09798.4 CDI80183.1 - 0.9 7.4 12.2 0.98 7.3 8.4 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein Glycoprotein_G PF00802.14 CDI80183.1 - 1.5 7.9 8.6 1.7 7.6 6.0 1.0 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G Activator_LAG-3 PF11498.3 CDI80183.1 - 1.8 7.2 28.4 2 7.0 19.7 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4175 PF13779.1 CDI80183.1 - 2.3 5.8 22.8 2.5 5.6 15.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SAPS PF04499.10 CDI80183.1 - 4.6 5.7 11.8 5.2 5.5 8.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein IER PF05760.7 CDI80183.1 - 5 6.9 14.1 5.5 6.8 9.8 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) PIG-S PF10510.4 CDI80183.1 - 5.2 5.6 11.3 5.8 5.4 7.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein FAM176 PF14851.1 CDI80183.1 - 6.2 6.4 7.0 7.9 6.1 4.9 1.2 1 0 0 1 1 1 0 FAM176 family DUF4045 PF13254.1 CDI80183.1 - 7.4 5.7 12.3 8 5.6 8.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MCPVI PF02993.9 CDI80183.1 - 7.8 6.5 12.6 9.3 6.3 8.8 1.0 1 0 0 1 1 1 0 Minor capsid protein VI Hid1 PF12722.2 CDI80183.1 - 8.8 3.8 10.3 9.4 3.7 7.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_S64 PF08192.6 CDI80183.1 - 8.8 4.5 8.0 9.9 4.3 5.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 VIT1 PF01988.14 CDI80183.1 - 9.5 5.6 8.5 14 5.0 5.9 1.3 1 0 0 1 1 1 0 VIT family Ribosomal_S13 PF00416.17 CDI80184.1 - 6.9e-37 126.1 0.3 8.5e-37 125.8 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 CDI80184.1 - 0.0051 15.4 0.0 0.0051 15.4 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) AAA_23 PF13476.1 CDI80187.1 - 9.7e-05 22.7 15.7 0.00011 22.6 10.9 1.2 1 0 0 1 1 1 1 AAA domain IncA PF04156.9 CDI80187.1 - 0.014 14.9 17.2 0.023 14.2 12.0 1.4 1 0 0 1 1 1 0 IncA protein Cwf_Cwc_15 PF04889.7 CDI80187.1 - 0.026 14.2 31.1 0.043 13.5 21.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HSP70 PF00012.15 CDI80187.1 - 8 4.2 23.3 9.5 3.9 16.2 1.0 1 0 0 1 1 1 0 Hsp70 protein MobB PF03205.9 CDI80188.1 - 9.3e-06 25.3 0.0 7.3e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 CDI80188.1 - 0.0026 18.5 0.0 0.0058 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI80188.1 - 0.0081 16.1 0.2 0.0081 16.1 0.1 3.3 2 2 1 3 3 2 1 AAA ATPase domain AAA_29 PF13555.1 CDI80188.1 - 0.011 15.2 0.0 0.033 13.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.18 CDI80188.1 - 0.065 12.6 0.0 0.2 11.0 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.12 CDI80188.1 - 0.072 12.6 1.5 0.083 12.4 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 CDI80188.1 - 0.13 11.6 0.4 0.69 9.2 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain AAA_18 PF13238.1 CDI80188.1 - 0.15 12.3 1.1 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain Syntaxin-18_N PF10496.4 CDI80188.1 - 2.5 8.0 5.6 0.71 9.7 1.4 1.8 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Peptidase_S49_N PF08496.5 CDI80188.1 - 3.9 7.2 13.5 2.3 7.9 7.9 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Tom37_C PF11801.3 CDI80188.1 - 4 7.2 12.7 11 5.8 8.8 1.7 1 0 0 1 1 1 0 Tom37 C-terminal domain RELT PF12606.3 CDI80189.1 - 0.78 8.9 5.8 0.56 9.3 0.1 4.0 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 YjgP_YjgQ PF03739.9 CDI80191.1 - 1.8 7.2 3.4 2.4 6.8 2.3 1.3 1 1 0 1 1 1 0 Predicted permease YjgP/YjgQ family IGPS PF00218.16 CDI80192.1 - 9.8e-21 73.9 3.0 9.8e-21 73.9 2.1 4.6 3 2 2 5 5 5 1 Indole-3-glycerol phosphate synthase Activator_LAG-3 PF11498.3 CDI80192.1 - 5.6e-08 31.9 36.8 5.6e-08 31.9 25.5 5.4 5 0 0 5 5 5 1 Transcriptional activator LAG-3 Sel1 PF08238.7 CDI80194.1 - 3.5e-07 30.6 19.1 0.036 14.7 0.0 6.8 7 1 0 7 7 7 3 Sel1 repeat SR-25 PF10500.4 CDI80194.1 - 0.0098 15.3 5.1 0.0098 15.3 3.5 4.2 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein HTH_28 PF13518.1 CDI80194.1 - 0.018 15.0 0.0 0.054 13.5 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_L13 PF00572.13 CDI80195.1 - 7.1e-25 87.5 0.2 7.1e-25 87.5 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L13 Dscam_C PF12355.3 CDI80197.1 - 0.47 10.7 6.4 0.35 11.1 3.8 1.3 1 1 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Atg14 PF10186.4 CDI80199.1 - 0.005 15.8 32.5 0.005 15.8 22.5 6.7 3 1 2 7 7 7 1 UV radiation resistance protein and autophagy-related subunit 14 Reo_sigmaC PF04582.7 CDI80199.1 - 5 6.2 18.4 5.9 5.9 0.7 4.5 1 1 2 4 4 4 0 Reovirus sigma C capsid protein RRM_1 PF00076.17 CDI80200.1 - 6.9e-29 99.2 0.0 1.6e-17 62.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80200.1 - 1.9e-19 69.3 0.0 1.4e-11 44.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80200.1 - 1.3e-07 31.3 0.0 9.8e-06 25.3 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 CDI80201.1 - 1.8e-43 148.5 0.0 8e-40 136.6 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80201.1 - 3.1e-28 98.5 0.0 4.9e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI80201.1 - 4.1e-08 32.5 0.0 7.2e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Tubulin PF00091.20 CDI80202.1 - 1.2e-26 93.8 0.0 2.1e-18 66.9 0.0 2.1 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.4 CDI80202.1 - 0.0087 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Dynein_heavy PF03028.10 CDI80203.1 - 1.4e-30 105.9 0.0 1.6e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor UreF PF01730.11 CDI80203.1 - 0.055 13.5 0.5 0.099 12.7 0.3 1.5 1 0 0 1 1 1 0 UreF Peripla_BP_3 PF13377.1 CDI80203.1 - 0.088 12.8 1.1 0.28 11.1 0.3 2.0 1 1 1 2 2 2 0 Periplasmic binding protein-like domain DHC_N2 PF08393.8 CDI80204.1 - 2.5e-85 286.4 0.1 2.5e-85 286.4 0.1 2.4 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 CDI80204.1 - 1.1e-78 263.9 0.0 2.2e-78 262.9 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 MT PF12777.2 CDI80204.1 - 9e-57 192.3 3.9 2e-56 191.1 2.7 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 CDI80204.1 - 1.7e-27 95.7 0.0 8.7e-13 47.6 0.0 2.4 2 0 0 2 2 2 2 ATP-binding dynein motor region D5 AAA_8 PF12780.2 CDI80204.1 - 3.1e-22 78.8 0.0 1.6e-20 73.1 0.0 2.9 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_heavy PF03028.10 CDI80204.1 - 3.6e-20 71.5 2.0 3e-19 68.5 0.0 2.3 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_7 PF12775.2 CDI80204.1 - 1.7e-11 43.7 0.0 1.2e-05 24.6 0.0 2.6 3 0 0 3 3 3 2 P-loop containing dynein motor region D3 AAA_5 PF07728.9 CDI80204.1 - 1.2e-05 25.0 5.1 0.14 11.8 0.0 5.5 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) AAA PF00004.24 CDI80204.1 - 0.001 19.2 0.4 0.29 11.3 0.0 4.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 CDI80204.1 - 0.099 12.8 0.7 19 5.4 0.0 3.2 3 0 0 3 3 3 0 RNA helicase AAA_17 PF13207.1 CDI80204.1 - 0.13 13.1 0.5 1.7 9.4 0.0 3.2 3 0 0 3 3 2 0 AAA domain GTP_EFTU PF00009.22 CDI80204.1 - 0.57 9.5 0.1 2.3 7.6 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Kin17_mid PF10357.4 CDI80208.1 - 3.1e-42 143.1 3.8 3.1e-42 143.1 2.6 2.0 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein Vps5 PF09325.5 CDI80208.1 - 0.002 17.4 0.2 0.002 17.4 0.1 2.1 2 0 0 2 2 2 1 Vps5 C terminal like DUF3252 PF11623.3 CDI80208.1 - 0.12 11.7 0.1 0.27 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3252) DUF4591 PF15261.1 CDI80208.1 - 0.41 10.9 15.9 0.91 9.7 11.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4591) ABC_tran PF00005.22 CDI80211.1 - 3.6e-05 24.0 0.0 5.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 CDI80211.1 - 0.00044 19.5 0.1 0.0006 19.1 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDI80211.1 - 0.031 14.2 0.0 0.072 13.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.1 CDI80211.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Clathrin PF00637.15 CDI80213.1 - 4.2e-06 26.4 0.3 0.0043 16.6 0.0 2.7 2 1 0 2 2 2 2 Region in Clathrin and VPS PPR PF01535.15 CDI80213.1 - 0.0085 16.0 5.0 58 3.9 0.0 5.2 4 0 0 4 4 4 0 PPR repeat Coatomer_WDAD PF04053.9 CDI80213.1 - 0.074 11.8 5.6 1.4 7.5 0.2 2.3 2 0 0 2 2 2 0 Coatomer WD associated region PPR_3 PF13812.1 CDI80213.1 - 0.12 12.7 10.1 17 6.0 0.1 6.1 3 2 3 6 6 6 0 Pentatricopeptide repeat domain PPR_2 PF13041.1 CDI80213.1 - 0.43 10.6 1.4 13 5.8 0.0 3.6 3 2 1 4 4 4 0 PPR repeat family RPN7 PF10602.4 CDI80213.1 - 0.69 9.2 3.4 0.86 8.9 0.0 2.6 3 2 0 3 3 3 0 26S proteasome subunit RPN7 TPR_14 PF13428.1 CDI80213.1 - 2.6 8.9 21.3 36 5.3 1.2 6.8 2 2 3 5 5 5 0 Tetratricopeptide repeat DUF3293 PF11697.3 CDI80213.1 - 7.2 6.8 6.8 10 6.3 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3293) DUF972 PF06156.8 CDI80214.1 - 0.0019 18.5 6.0 0.0019 18.5 4.2 2.7 1 1 1 2 2 2 1 Protein of unknown function (DUF972) KdpC PF02669.10 CDI80214.1 - 0.06 13.0 11.2 0.19 11.4 0.3 2.6 2 0 0 2 2 2 0 K+-transporting ATPase, c chain DUF2009 PF09418.5 CDI80214.1 - 0.1 11.3 7.1 0.15 10.8 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) SPX PF03105.14 CDI80214.1 - 0.17 11.6 11.1 0.22 11.3 7.7 1.3 1 0 0 1 1 1 0 SPX domain DUF342 PF03961.8 CDI80214.1 - 0.39 9.0 11.5 0.59 8.4 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Cytokin-bind PF09265.5 CDI80214.1 - 1.2 8.2 6.1 2.1 7.4 4.3 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Spc7 PF08317.6 CDI80214.1 - 1.5 7.3 20.9 2.5 6.6 14.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Hemerythrin PF01814.18 CDI80214.1 - 2.2 8.4 14.7 0.087 12.9 4.2 2.9 2 2 1 3 3 3 0 Hemerythrin HHE cation binding domain V_ATPase_I PF01496.14 CDI80214.1 - 4.5 5.0 18.5 8.2 4.1 12.8 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family PLRV_ORF5 PF01690.12 CDI80214.1 - 6.4 5.8 18.5 12 4.8 12.8 1.5 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein BTV_NS2 PF04514.7 CDI80214.1 - 9.4 5.0 13.0 16 4.2 9.0 1.5 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Cep57_MT_bd PF06657.8 CDI80215.1 - 0.059 13.3 3.3 0.13 12.1 2.3 1.6 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Cobl PF09469.5 CDI80215.1 - 2.5 8.1 4.5 4.1 7.4 0.2 2.4 2 0 0 2 2 2 0 Cordon-bleu ubiquitin-like domain Na_sulph_symp PF00939.14 CDI80217.1 - 2.8e-20 72.6 4.8 8.9e-18 64.4 0.9 2.2 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 CDI80217.1 - 1.4e-06 27.1 13.4 3.8e-06 25.7 4.9 2.2 2 0 0 2 2 2 2 Citrate transporter DUF4557 PF15101.1 CDI80217.1 - 0.22 11.3 3.3 0.42 10.4 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) BAF1_ABF1 PF04684.8 CDI80219.1 - 0.00065 18.6 8.5 0.00065 18.6 5.9 3.4 4 0 0 4 4 4 1 BAF1 / ABF1 chromatin reorganising factor Pex14_N PF04695.8 CDI80219.1 - 0.001 19.1 6.9 0.001 19.1 4.8 3.7 3 2 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PUB PF09409.5 CDI80219.1 - 0.074 12.8 0.0 0.45 10.3 0.0 2.2 1 1 0 1 1 1 0 PUB domain Med15 PF09606.5 CDI80220.1 - 2.8e-06 25.8 70.4 0.00013 20.3 32.3 2.2 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal Caldesmon PF02029.10 CDI80220.1 - 3.7e-05 22.3 13.2 3.7e-05 22.3 9.2 3.0 3 0 0 3 3 3 1 Caldesmon TFIIA PF03153.8 CDI80220.1 - 6.2e-05 23.0 43.5 0.00017 21.6 19.8 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI80220.1 - 0.0013 17.0 39.0 0.0013 17.0 27.0 2.1 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 Spore_coat_CotO PF14153.1 CDI80220.1 - 0.0028 17.1 28.9 0.0028 17.1 20.0 3.2 3 0 0 3 3 3 1 Spore coat protein CotO CDC27 PF09507.5 CDI80220.1 - 0.0031 16.8 24.9 0.0031 16.8 17.2 2.1 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 eIF-3_zeta PF05091.7 CDI80220.1 - 0.017 13.8 27.1 0.039 12.5 12.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TT_ORF1 PF02956.9 CDI80220.1 - 0.047 12.1 16.7 0.27 9.6 0.3 2.1 2 0 0 2 2 2 0 TT viral orf 1 Zip PF02535.17 CDI80220.1 - 0.068 12.1 11.5 0.29 10.0 5.5 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter AvrE PF11725.3 CDI80220.1 - 0.16 8.9 34.3 0.0069 13.4 15.5 2.0 2 0 0 2 2 2 0 Pathogenicity factor Spore_YhcN_YlaJ PF09580.5 CDI80220.1 - 0.19 11.8 26.9 0.54 10.3 0.2 2.4 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Vfa1 PF08432.5 CDI80220.1 - 0.41 10.6 39.2 0.052 13.5 13.6 3.2 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 Serinc PF03348.10 CDI80220.1 - 0.5 9.0 25.9 0.97 8.0 1.0 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.11 CDI80220.1 - 0.53 10.1 23.1 0.93 9.3 10.6 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.3 CDI80220.1 - 0.58 8.2 22.7 0.25 9.4 8.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) SOBP PF15279.1 CDI80220.1 - 0.59 10.4 23.5 0.99 9.7 10.7 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein Hid1 PF12722.2 CDI80220.1 - 0.94 7.0 31.7 0.28 8.8 13.1 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein FAP PF07174.6 CDI80220.1 - 1.1 8.5 15.2 2.1 7.5 10.5 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DUF966 PF06136.8 CDI80220.1 - 1.2 8.5 25.6 0.5 9.7 10.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) PBP1_TM PF14812.1 CDI80220.1 - 1.3 9.3 27.0 0.15 12.3 8.2 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Daxx PF03344.10 CDI80220.1 - 1.9 6.8 46.4 0.048 12.1 21.2 2.1 2 0 0 2 2 2 0 Daxx Family POP1 PF06978.6 CDI80220.1 - 3.3 7.3 21.1 7.7 6.1 8.8 2.6 2 0 0 2 2 2 0 Ribonucleases P/MRP protein subunit POP1 CENP-T PF15511.1 CDI80220.1 - 4.1 6.5 39.3 1 8.5 18.8 2.4 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T LicD PF04991.8 CDI80220.1 - 4.2 7.4 6.3 38 4.2 0.0 2.3 2 0 0 2 2 2 0 LicD family GAGA_bind PF06217.7 CDI80220.1 - 4.4 7.1 30.2 8.4 6.2 14.8 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family Peptidase_S15 PF02129.13 CDI80220.1 - 4.7 6.5 21.1 6.5 6.0 7.6 2.4 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) ABC2_membrane_2 PF12679.2 CDI80220.1 - 4.8 5.9 4.3 0.63 8.8 0.2 1.6 2 0 0 2 2 2 0 ABC-2 family transporter protein Herpes_DNAp_acc PF04929.7 CDI80220.1 - 7.1 5.4 23.2 12 4.7 0.1 2.4 2 0 0 2 2 2 0 Herpes DNA replication accessory factor Otopetrin PF03189.8 CDI80220.1 - 7.2 5.4 11.7 5.4 5.8 4.6 2.2 2 0 0 2 2 2 0 Otopetrin Peptidase_C37 PF05416.7 CDI80220.1 - 9 4.4 16.3 0.61 8.3 0.7 2.3 2 0 0 2 2 2 0 Southampton virus-type processing peptidase Paramyxo_ncap PF00973.14 CDI80220.1 - 9.8 4.7 28.9 2.2 6.8 11.0 2.3 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein RAB3GAP2_N PF14655.1 CDI80221.1 - 0.09 11.7 7.5 0.75 8.7 1.9 2.5 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Neur_chan_memb PF02932.11 CDI80221.1 - 6.5 6.5 8.0 13 5.6 4.1 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region HK97-gp10_like PF04883.7 CDI80221.1 - 6.6 7.7 7.4 46 5.0 5.1 2.5 1 1 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component P12 PF12669.2 CDI80224.1 - 0.0019 18.3 3.2 0.0041 17.2 2.2 1.6 1 0 0 1 1 1 1 Virus attachment protein p12 family CheR_N PF03705.10 CDI80224.1 - 0.17 11.2 0.4 9.8 5.6 0.7 2.5 2 0 0 2 2 2 0 CheR methyltransferase, all-alpha domain Hydrolase_4 PF12146.3 CDI80225.1 - 2.5e-10 40.0 0.1 8.2e-07 28.7 0.0 2.4 2 0 0 2 2 2 2 Putative lysophospholipase DUF2205 PF10224.4 CDI80227.1 - 0.00095 18.6 8.6 0.00095 18.6 6.0 2.0 1 1 1 2 2 2 1 Predicted coiled-coil protein (DUF2205) Mod_r PF07200.8 CDI80227.1 - 0.0021 18.0 11.8 0.0038 17.1 8.2 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF972 PF06156.8 CDI80227.1 - 0.0023 18.2 10.5 0.0047 17.2 7.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF972) CENP-F_leu_zip PF10473.4 CDI80227.1 - 0.0031 17.3 11.3 0.0054 16.5 7.8 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_L29 PF00831.18 CDI80227.1 - 0.025 14.2 0.5 0.025 14.2 0.4 2.5 1 1 1 2 2 2 0 Ribosomal L29 protein SGT1 PF07093.6 CDI80227.1 - 0.037 12.4 6.8 0.041 12.2 4.7 1.1 1 0 0 1 1 1 0 SGT1 protein NfrA_C PF13283.1 CDI80227.1 - 0.039 13.3 0.2 2.4 7.4 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage N adsorption protein A C-term RAP1 PF07218.6 CDI80227.1 - 0.14 10.2 4.9 0.18 9.8 3.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AAA_23 PF13476.1 CDI80227.1 - 0.2 11.9 9.8 0.26 11.6 6.8 1.2 1 0 0 1 1 1 0 AAA domain DUF3138 PF11336.3 CDI80227.1 - 0.32 9.1 9.9 0.43 8.7 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Spc7 PF08317.6 CDI80227.1 - 0.34 9.5 9.3 0.48 9.0 6.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.14 CDI80227.1 - 0.41 8.4 4.7 0.47 8.2 3.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.3 CDI80227.1 - 0.48 9.0 4.3 0.6 8.7 3.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DivIVA PF05103.8 CDI80227.1 - 1.5 8.8 17.3 4.6 7.2 12.0 1.9 1 1 0 1 1 1 0 DivIVA protein CDK2AP PF09806.4 CDI80227.1 - 1.7 8.8 19.8 1.9 8.6 7.2 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Macoilin PF09726.4 CDI80227.1 - 3.8 5.6 23.1 6.4 4.9 16.0 1.3 1 1 0 1 1 1 0 Transmembrane protein Borrelia_P83 PF05262.6 CDI80227.1 - 4 5.5 11.5 4.7 5.3 8.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Apc15p PF05841.6 CDI80227.1 - 4.3 8.1 14.6 5.5 7.7 3.4 2.3 2 0 0 2 2 2 0 Apc15p protein SOBP PF15279.1 CDI80227.1 - 4.8 7.4 14.7 5.9 7.1 10.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein IncA PF04156.9 CDI80230.1 - 0.0085 15.6 13.8 0.012 15.1 9.5 1.2 1 0 0 1 1 1 1 IncA protein Cwf_Cwc_15 PF04889.7 CDI80230.1 - 0.23 11.1 10.1 0.29 10.8 7.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Med15 PF09606.5 CDI80230.1 - 0.42 8.7 47.9 0.5 8.5 33.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal GAGA_bind PF06217.7 CDI80230.1 - 1.1 9.1 7.5 1.2 9.0 5.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hid1 PF12722.2 CDI80230.1 - 1.3 6.6 8.2 1.3 6.5 5.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.1 CDI80230.1 - 1.6 7.1 9.0 2 6.8 6.2 1.1 1 0 0 1 1 1 0 Raftlin Neur_chan_memb PF02932.11 CDI80230.1 - 2.2 8.0 5.1 2.4 7.9 3.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BTV_NS2 PF04514.7 CDI80230.1 - 3.2 6.5 8.0 3.8 6.3 5.6 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DDHD PF02862.12 CDI80230.1 - 3.6 7.3 8.4 4.5 7.0 5.8 1.3 1 0 0 1 1 1 0 DDHD domain Parvo_coat PF00740.13 CDI80230.1 - 3.7 6.3 11.9 4.3 6.1 8.2 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 FAM60A PF15396.1 CDI80230.1 - 4.3 7.0 7.7 5.7 6.6 5.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF3449 PF11931.3 CDI80230.1 - 5.3 6.4 10.5 6.9 6.1 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) FLO_LFY PF01698.11 CDI80230.1 - 6.7 5.4 10.0 7.8 5.2 7.0 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Spore_coat_CotO PF14153.1 CDI80230.1 - 7.5 5.9 16.7 11 5.4 11.6 1.3 1 0 0 1 1 1 0 Spore coat protein CotO PPP4R2 PF09184.6 CDI80230.1 - 9.5 5.6 10.1 12 5.3 7.0 1.1 1 0 0 1 1 1 0 PPP4R2 Cullin PF00888.17 CDI80233.1 - 7.3e-43 146.9 0.0 3.2e-42 144.8 0.0 1.7 2 0 0 2 2 2 1 Cullin family SR-25 PF10500.4 CDI80233.1 - 0.0081 15.6 8.6 0.013 14.9 6.0 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF3446 PF11928.3 CDI80233.1 - 0.019 15.1 5.0 0.039 14.1 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF1117 PF06547.7 CDI80233.1 - 0.59 10.2 4.5 0.4 10.7 1.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) DUF755 PF05501.6 CDI80233.1 - 5.8 7.0 15.1 3.7 7.6 8.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Med15 PF09606.5 CDI80234.1 - 0.0022 16.3 13.9 0.0022 16.3 9.6 2.1 2 1 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal BAF1_ABF1 PF04684.8 CDI80234.1 - 0.0079 15.1 15.0 0.0079 15.1 10.4 3.3 3 1 0 3 3 3 1 BAF1 / ABF1 chromatin reorganising factor Spt20 PF12090.3 CDI80234.1 - 0.01 15.2 2.6 0.013 14.8 1.8 1.2 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.4 CDI80234.1 - 0.039 12.2 15.3 0.05 11.8 10.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.9 CDI80234.1 - 0.04 13.6 5.3 0.052 13.2 3.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FimP PF09766.4 CDI80234.1 - 0.27 10.2 8.6 0.38 9.7 5.9 1.1 1 0 0 1 1 1 0 Fms-interacting protein RED_N PF07808.8 CDI80234.1 - 0.8 8.8 6.8 1.2 8.3 4.7 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region Pex14_N PF04695.8 CDI80234.1 - 1.6 8.7 15.3 0.16 12.0 6.1 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DivIC PF04977.10 CDI80234.1 - 2.3 7.7 10.1 4.8 6.7 7.0 1.5 1 0 0 1 1 1 0 Septum formation initiator SR-25 PF10500.4 CDI80234.1 - 5.1 6.4 14.6 9.1 5.6 0.6 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TSP_1 PF00090.14 CDI80235.1 - 2.2e-06 27.6 0.7 2.2e-06 27.6 0.5 3.2 3 0 0 3 3 3 1 Thrombospondin type 1 domain TcdB_N PF12918.2 CDI80235.1 - 0.046 13.8 0.1 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain PAT1 PF09770.4 CDI80235.1 - 3.2 5.8 41.6 1.4 7.0 4.3 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PAN_4 PF14295.1 CDI80236.1 - 9.1e-17 60.5 23.1 1.8e-05 24.3 0.5 5.4 5 0 0 5 5 5 4 PAN domain PAN_1 PF00024.21 CDI80236.1 - 2.6e-10 39.8 25.5 0.00016 21.3 0.4 5.6 4 1 1 5 5 5 4 PAN domain PAN_2 PF08276.6 CDI80236.1 - 0.0055 16.5 28.1 0.09 12.6 0.3 5.1 5 0 0 5 5 5 3 PAN-like domain DUF3446 PF11928.3 CDI80236.1 - 1.4 9.1 27.6 1.3 9.2 7.5 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3446) Med15 PF09606.5 CDI80240.1 - 1.7 6.7 45.6 0.69 8.0 8.0 2.5 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal E1_dh PF00676.15 CDI80241.1 - 0.007 15.1 0.4 0.007 15.1 0.3 2.6 2 2 2 4 4 4 1 Dehydrogenase E1 component AP2 PF00847.15 CDI80241.1 - 0.054 13.6 4.1 0.13 12.4 0.0 2.6 2 0 0 2 2 2 0 AP2 domain Pro_isomerase PF00160.16 CDI80242.1 - 1.6e-28 99.8 0.0 1.4e-27 96.8 0.0 2.4 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.4 CDI80242.1 - 0.0032 16.9 16.4 0.0032 16.9 11.4 4.0 3 1 0 4 4 4 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 CDI80242.1 - 7.6 4.6 44.5 2.2 6.4 9.2 2.1 1 1 1 2 2 2 0 Transmembrane protein AAA_23 PF13476.1 CDI80242.1 - 8.2 6.6 14.6 23 5.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain Condensation PF00668.15 CDI80246.1 - 2.5e-06 26.5 1.3 0.25 10.1 0.0 4.3 4 0 0 4 4 4 3 Condensation domain AATase PF07247.7 CDI80246.1 - 0.063 11.8 0.0 0.46 8.9 0.0 2.3 3 0 0 3 3 3 0 Alcohol acetyltransferase Acatn PF13000.2 CDI80246.1 - 1.3 7.5 0.0 2.1 6.7 0.0 1.2 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 JmjC PF02373.17 CDI80250.1 - 8.6e-34 116.2 1.2 8.6e-34 116.2 0.8 2.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-C5HC2 PF02928.11 CDI80250.1 - 0.00065 19.7 18.0 0.0012 18.8 12.5 1.5 1 0 0 1 1 1 1 C5HC2 zinc finger JmjN PF02375.12 CDI80250.1 - 0.019 14.4 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 jmjN domain Arf PF00025.16 CDI80251.1 - 4.7e-22 78.0 0.0 1.9e-12 46.8 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.15 CDI80251.1 - 0.00083 18.1 1.2 0.00083 18.1 0.8 1.8 2 1 1 3 3 3 1 G-protein alpha subunit SRPRB PF09439.5 CDI80251.1 - 0.0033 16.6 0.0 0.17 11.1 0.0 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 CDI80251.1 - 0.0054 16.6 0.1 0.068 13.1 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDI80251.1 - 0.043 14.2 1.5 0.061 13.8 0.0 2.2 3 1 0 3 3 3 0 Miro-like protein Pex16 PF08610.5 CDI80251.1 - 0.12 11.3 1.0 0.17 10.8 0.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DDHD PF02862.12 CDI80251.1 - 0.12 12.1 0.7 0.19 11.5 0.5 1.3 1 0 0 1 1 1 0 DDHD domain Dot_icm_IcmQ PF09475.5 CDI80251.1 - 0.24 10.6 1.8 0.41 9.8 1.3 1.3 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Activator_LAG-3 PF11498.3 CDI80251.1 - 0.91 8.2 24.5 1.5 7.5 17.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Gtr1_RagA PF04670.7 CDI80251.1 - 1.3 8.1 3.5 19 4.2 0.0 2.8 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region Condensation PF00668.15 CDI80251.1 - 3.9 6.2 11.8 3.2 6.5 3.3 2.2 2 0 0 2 2 2 0 Condensation domain Pex14_N PF04695.8 CDI80251.1 - 5.5 7.0 20.3 0.14 12.2 4.4 2.6 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Arf PF00025.16 CDI80252.1 - 5.8e-07 28.9 0.0 6.5e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Pex14_N PF04695.8 CDI80252.1 - 0.00011 22.2 4.7 0.00015 21.7 3.3 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PRCC PF10253.4 CDI80252.1 - 0.0081 16.8 5.3 0.0093 16.6 3.6 1.1 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting DUF4614 PF15391.1 CDI80252.1 - 0.074 12.8 8.0 0.085 12.6 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.4 CDI80252.1 - 0.19 10.0 6.2 0.22 9.7 4.3 1.2 1 0 0 1 1 1 0 Transmembrane protein Suf PF05843.9 CDI80252.1 - 0.19 11.4 2.8 0.2 11.3 1.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spc7_N PF15402.1 CDI80252.1 - 0.25 9.2 8.2 0.29 9.1 5.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 AF-4 PF05110.8 CDI80252.1 - 1.2 6.9 13.5 1.4 6.7 9.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM60A PF15396.1 CDI80252.1 - 2.5 7.7 6.3 3.4 7.3 4.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Corona_nucleoca PF00937.13 CDI80252.1 - 4.8 6.0 13.7 6 5.7 9.5 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Apt1 PF10351.4 CDI80252.1 - 9.3 4.9 11.0 11 4.7 7.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPRY PF00622.23 CDI80253.1 - 0.006 16.6 1.7 5.9 6.9 0.0 4.4 5 0 0 5 5 5 2 SPRY domain Helicase_C PF00271.26 CDI80254.1 - 6.9e-07 29.0 0.0 6.9e-07 29.0 0.0 7.4 9 0 0 9 9 9 1 Helicase conserved C-terminal domain MarC PF01914.12 CDI80254.1 - 0.047 12.8 5.8 0.057 12.5 0.2 4.0 3 0 0 3 3 3 0 MarC family integral membrane protein SecD_SecF PF02355.11 CDI80254.1 - 2.7 7.1 0.0 6.1 5.9 0.0 1.5 1 0 0 1 1 1 0 Protein export membrane protein cNMP_binding PF00027.24 CDI80255.1 - 5.6e-24 83.7 0.0 1.1e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_23 PF13476.1 CDI80255.1 - 0.25 11.6 4.9 0.35 11.1 3.4 1.2 1 0 0 1 1 1 0 AAA domain YfhO PF09586.5 CDI80255.1 - 0.77 7.7 5.6 0.94 7.4 3.9 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SR-25 PF10500.4 CDI80257.1 - 0.00016 21.2 1.6 0.00019 21.0 1.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF3446 PF11928.3 CDI80257.1 - 0.0023 18.0 0.5 0.0028 17.7 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3446) Spore_III_AF PF09581.5 CDI80257.1 - 0.061 13.1 3.3 0.073 12.9 2.3 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Gastrin PF00918.12 CDI80257.1 - 0.15 12.8 4.8 0.19 12.5 3.3 1.2 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Presenilin PF01080.12 CDI80257.1 - 0.26 10.0 2.1 0.28 9.9 1.4 1.0 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.8 CDI80257.1 - 0.4 10.7 7.2 0.5 10.4 5.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Exonuc_X-T_C PF08411.5 CDI80257.1 - 0.54 9.2 6.9 0.71 8.8 4.1 1.6 2 0 0 2 2 2 0 Exonuclease C-terminal RRM_1 PF00076.17 CDI80258.1 - 9.7e-30 102.0 0.7 7.9e-16 57.4 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80258.1 - 2e-22 78.9 0.4 6.1e-10 38.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80258.1 - 1.3e-07 31.3 1.3 0.0067 16.2 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF605 PF04652.11 CDI80258.1 - 0.00092 18.7 5.6 0.0011 18.4 3.9 1.1 1 0 0 1 1 1 1 Vta1 like Apt1 PF10351.4 CDI80258.1 - 0.062 12.1 11.0 0.079 11.8 7.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hid1 PF12722.2 CDI80258.1 - 0.18 9.4 7.3 0.24 9.0 5.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pex14_N PF04695.8 CDI80258.1 - 0.32 11.0 12.6 0.81 9.7 8.7 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4614 PF15391.1 CDI80258.1 - 0.38 10.5 13.5 0.61 9.8 9.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Sporozoite_P67 PF05642.6 CDI80258.1 - 0.84 7.4 11.3 1.1 7.0 7.8 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MIP-T3 PF10243.4 CDI80258.1 - 0.95 7.8 7.8 1.3 7.3 5.4 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3827 PF12877.2 CDI80258.1 - 1.1 7.2 10.7 1.6 6.7 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CDC45 PF02724.9 CDI80258.1 - 1.9 6.3 7.2 2.6 5.9 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2215 PF10225.4 CDI80258.1 - 2.2 7.6 5.9 3.2 7.1 4.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) DUF2146 PF10220.4 CDI80258.1 - 2.8 5.8 5.5 4.3 5.1 3.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) DUF566 PF04484.7 CDI80258.1 - 3.3 7.1 19.7 4.8 6.5 13.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) APC_CDC26 PF10471.4 CDI80258.1 - 6.4 7.5 8.3 13 6.6 5.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 DUF572 PF04502.8 CDI80258.1 - 9.4 5.3 10.6 15 4.6 7.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Med15 PF09606.5 CDI80259.1 - 0.00011 20.5 80.1 0.00013 20.3 55.5 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Macoilin PF09726.4 CDI80259.1 - 0.8 7.9 48.1 1.2 7.2 33.4 1.3 1 0 0 1 1 1 0 Transmembrane protein THRAP3_BCLAF1 PF15440.1 CDI80259.1 - 1.3 7.5 34.2 1.9 7.0 23.7 1.2 1 0 0 1 1 1 0 THRAP3/BCLAF1 family IncA PF04156.9 CDI80259.1 - 2.1 7.9 59.8 0.38 10.3 35.4 3.0 1 1 1 2 2 2 0 IncA protein DUF3584 PF12128.3 CDI80259.1 - 9 3.4 48.8 11 3.1 33.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Helicase_C_2 PF13307.1 CDI80260.1 - 6.4e-08 32.7 0.0 6.4e-08 32.7 0.0 2.9 3 2 0 3 3 3 1 Helicase C-terminal domain zf-C3HC4_3 PF13920.1 CDI80260.1 - 1.5e-06 27.7 8.0 2.7e-06 26.9 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 CDI80260.1 - 0.00081 18.8 3.1 0.0031 17.0 2.1 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.1 CDI80260.1 - 0.0032 17.1 6.9 0.0061 16.2 3.8 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDI80260.1 - 0.0066 16.4 7.4 0.012 15.5 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI80260.1 - 0.008 15.9 7.6 0.016 15.0 5.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDI80260.1 - 0.036 13.7 3.3 0.14 11.8 2.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 CDI80260.1 - 0.074 12.6 5.7 0.16 11.5 4.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Herpes_UL87 PF03043.9 CDI80260.1 - 0.8 8.0 22.0 7.2 4.8 5.8 2.4 1 1 1 2 2 2 0 Herpesvirus UL87 family Ycf1 PF05758.7 CDI80262.1 - 0.0016 16.3 8.2 0.0016 16.3 5.7 2.1 2 0 0 2 2 2 2 Ycf1 PP-binding_2 PF14573.1 CDI80263.1 - 2.1e-13 50.1 0.0 2.7e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-carrier DUF1690 PF07956.6 CDI80263.1 - 0.087 12.8 0.1 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) FKBP_C PF00254.23 CDI80264.1 - 2.2e-28 98.1 0.0 3.4e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 CDI80265.1 - 7.5e-20 70.3 17.1 2.3e-10 39.9 0.8 2.4 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.12 CDI80265.1 - 5.2e-08 32.2 12.4 0.00034 20.3 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDI80265.1 - 1.4e-07 31.4 1.5 0.00046 20.5 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDI80265.1 - 2.1e-07 30.2 7.8 0.015 14.8 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDI80265.1 - 1.7e-06 28.5 6.7 1.2e-05 25.8 2.5 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDI80265.1 - 6.3e-06 26.4 0.7 0.0023 18.2 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI80265.1 - 1.6e-05 24.7 0.5 0.23 11.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDI80265.1 - 9.6e-05 21.9 3.7 0.34 10.8 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat Pro_isomerase PF00160.16 CDI80265.1 - 0.00086 19.5 0.0 0.0019 18.4 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_9 PF13371.1 CDI80265.1 - 0.0025 17.6 0.5 0.0071 16.1 0.3 1.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDI80265.1 - 0.007 16.2 2.5 0.018 14.9 0.5 2.4 1 1 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 CDI80265.1 - 0.083 13.0 3.3 0.11 12.6 0.2 2.4 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 CDI80265.1 - 0.66 10.5 2.7 16 6.2 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 CDI80265.1 - 2.6 8.0 9.2 2.5 8.0 0.5 2.7 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF2508 PF10704.4 CDI80265.1 - 2.7 8.2 6.4 4.4 7.5 0.5 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF2508) Fucose_iso_N2 PF07882.7 CDI80267.1 - 5.2 6.6 5.8 1.3 8.6 1.7 1.7 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain ArfGap PF01412.13 CDI80268.1 - 3.2e-27 94.6 0.0 6.6e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-CCCH PF00642.19 CDI80270.1 - 0.0015 18.1 4.6 0.0015 18.1 3.2 1.6 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) BNIP3 PF06553.7 CDI80275.1 - 0.073 12.4 5.1 0.1 11.9 3.6 1.2 1 0 0 1 1 1 0 BNIP3 SR-25 PF10500.4 CDI80275.1 - 0.26 10.7 8.3 0.45 9.9 5.8 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein E1-E2_ATPase PF00122.15 CDI80277.1 - 0.0069 15.4 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase AP2 PF00847.15 CDI80280.1 - 0.39 10.8 0.0 0.39 10.8 0.0 4.9 6 0 0 6 6 6 0 AP2 domain TPR_2 PF07719.12 CDI80281.1 - 0.0014 18.3 0.0 2.4 8.2 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDI80281.1 - 0.0027 17.3 0.2 0.85 9.3 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 CDI80281.1 - 0.014 14.9 0.3 3.7 7.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 CDI80281.1 - 0.056 13.5 1.8 1.2 9.2 0.0 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 CDI80282.1 - 6.7e-18 64.7 0.2 9.5e-07 29.0 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat Apc3 PF12895.2 CDI80282.1 - 3.1e-14 52.8 3.9 6.7e-05 22.9 0.7 3.3 2 1 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 CDI80282.1 - 1.7e-11 44.4 3.9 6.4e-06 26.6 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI80282.1 - 3.1e-10 39.1 10.5 0.022 14.6 1.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 CDI80282.1 - 2.5e-09 36.6 5.6 0.0016 18.0 0.3 3.4 3 0 0 3 3 3 3 TPR repeat TPR_6 PF13174.1 CDI80282.1 - 1.6e-08 34.4 4.3 0.017 15.5 0.7 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDI80282.1 - 3e-08 32.8 0.6 0.037 13.8 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDI80282.1 - 2e-07 30.2 9.5 0.15 11.7 1.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDI80282.1 - 4.9e-07 29.8 3.5 0.095 13.3 0.2 4.3 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDI80282.1 - 2e-05 24.4 6.7 0.12 12.2 0.5 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 CDI80282.1 - 2.2e-05 24.2 1.9 0.76 9.7 0.6 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDI80282.1 - 0.00026 20.8 4.7 2.6 8.0 0.1 3.9 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 CDI80282.1 - 0.003 17.3 1.7 1.3 8.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDI80282.1 - 0.0058 16.3 2.6 2.6 8.0 0.4 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR PF01535.15 CDI80282.1 - 0.015 15.2 1.5 23 5.2 0.0 4.7 5 0 0 5 5 5 0 PPR repeat YfiO PF13525.1 CDI80282.1 - 0.022 14.2 0.1 3.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Outer membrane lipoprotein Coatomer_E PF04733.9 CDI80282.1 - 0.026 13.6 0.7 2.2 7.4 0.0 2.5 2 1 1 3 3 3 0 Coatomer epsilon subunit Type_III_YscG PF09477.5 CDI80282.1 - 0.042 13.9 0.7 6.7 6.8 0.0 3.2 3 0 0 3 3 3 0 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_17 PF13431.1 CDI80282.1 - 0.056 13.6 0.5 35 4.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.1 CDI80282.1 - 0.1 11.7 0.7 7.8 5.5 0.0 2.2 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_3 PF07720.7 CDI80282.1 - 0.12 12.2 9.0 0.92 9.3 1.5 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Mhr1 PF12829.2 CDI80282.1 - 0.13 12.0 3.1 3.5 7.5 0.0 3.0 3 0 0 3 3 3 0 Transcriptional regulation of mitochondrial recombination SUI1 PF01253.17 CDI80283.1 - 1e-07 31.6 0.0 2.1e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Methyltransf_19 PF04672.7 CDI80283.1 - 0.0063 15.8 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl methyltransferase Ilar_coat PF01787.11 CDI80283.1 - 0.092 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Ilarvirus coat protein zf-His_Me_endon PF05551.6 CDI80284.1 - 0.007 16.3 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding loop region of homing endonuclease Aldo_ket_red PF00248.16 CDI80285.1 - 8.3e-33 113.4 0.8 2e-29 102.2 0.1 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family eIF-6 PF01912.13 CDI80285.1 - 0.14 11.1 0.0 3.9 6.5 0.0 2.1 2 0 0 2 2 2 0 eIF-6 family Aldo_ket_red PF00248.16 CDI80286.1 - 2.2e-37 128.4 0.0 3.2e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Spt20 PF12090.3 CDI80287.1 - 0.55 9.5 16.3 0.81 9.0 3.3 3.7 3 0 0 3 3 3 0 Spt20 family TPR_11 PF13414.1 CDI80288.1 - 2.3e-15 55.9 13.4 1.5e-09 37.3 0.5 3.5 2 2 2 4 4 4 2 TPR repeat TPR_16 PF13432.1 CDI80288.1 - 3.6e-07 30.6 7.7 3.6e-07 30.6 5.3 5.8 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDI80288.1 - 1.3e-06 27.6 6.3 0.061 12.9 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI80288.1 - 0.00037 20.1 5.2 0.0013 18.5 1.4 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 CDI80288.1 - 0.0021 18.5 3.5 0.0021 18.5 2.4 6.8 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDI80288.1 - 0.007 16.4 0.0 0.007 16.4 0.0 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDI80288.1 - 0.0079 16.0 0.4 0.0079 16.0 0.3 2.1 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 CDI80288.1 - 0.015 15.7 0.7 0.015 15.7 0.5 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI80288.1 - 1 9.2 8.5 0.74 9.7 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Abhydrolase_5 PF12695.2 CDI80293.1 - 0.062 13.0 1.4 0.084 12.6 0.0 1.9 3 0 0 3 3 3 0 Alpha/beta hydrolase family NAD_binding_8 PF13450.1 CDI80293.1 - 0.11 12.4 0.6 0.25 11.3 0.4 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain BAF1_ABF1 PF04684.8 CDI80293.1 - 5.4 5.7 16.8 8 5.1 11.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor tRNA-synt_1c PF00749.16 CDI80294.1 - 2.6e-71 239.8 0.0 2.8e-35 121.4 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain GST_C_2 PF13410.1 CDI80294.1 - 2.9e-07 30.2 0.1 8.6e-05 22.3 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CDI80294.1 - 0.00081 19.8 0.0 0.0036 17.7 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CDI80294.1 - 0.0013 18.6 0.0 0.0038 17.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ASFV_J13L PF05568.6 CDI80296.1 - 0.51 9.8 2.0 0.9 9.0 1.4 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF572 PF04502.8 CDI80297.1 - 0.29 10.2 10.0 0.43 9.7 6.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Med15 PF09606.5 CDI80298.1 - 0.002 16.4 31.7 0.002 16.4 22.0 8.4 6 2 2 8 8 8 3 ARC105 or Med15 subunit of Mediator complex non-fungal DNA_topoisoIV PF00521.15 CDI80299.1 - 2e-74 251.0 2.1 9.7e-46 156.4 0.0 2.1 1 1 1 2 2 2 2 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.8 CDI80299.1 - 8.7e-06 24.9 0.1 0.0013 18.0 0.0 2.8 3 0 0 3 3 3 1 DNA gyrase C-terminal domain, beta-propeller Peptidase_S46 PF10459.4 CDI80299.1 - 0.64 8.3 10.1 0.93 7.8 7.0 1.2 1 0 0 1 1 1 0 Peptidase S46 Laminin_II PF06009.7 CDI80299.1 - 5.5 6.7 14.1 6.5 6.5 2.1 2.4 2 0 0 2 2 2 0 Laminin Domain II Pro-rich PF15240.1 CDI80299.1 - 9.8 6.2 46.9 52 3.8 32.5 2.0 1 1 0 1 1 1 0 Proline-rich PNTB PF02233.11 CDI80300.1 - 2e-21 76.3 0.0 2.8e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 CDI80300.1 - 2.7e-13 49.8 0.1 9.9e-13 47.9 0.0 1.8 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TPP_enzyme_M PF00205.17 CDI80300.1 - 0.00022 21.0 0.0 0.00048 19.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain HI0933_like PF03486.9 CDI80300.1 - 0.0016 17.0 1.2 0.0023 16.4 0.8 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 CDI80300.1 - 0.0063 16.4 0.2 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDI80300.1 - 0.013 15.5 0.4 0.039 13.9 0.3 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CDI80300.1 - 0.015 14.2 1.7 0.026 13.3 1.2 1.4 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.12 CDI80300.1 - 0.031 13.3 0.1 0.053 12.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 CDI80300.1 - 0.041 13.9 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CDI80300.1 - 0.042 12.7 0.8 0.064 12.1 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_7 PF13241.1 CDI80300.1 - 0.057 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_N PF05222.10 CDI80300.1 - 0.12 12.4 0.0 9.5 6.2 0.0 2.6 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, N-terminal domain Pyr_redox PF00070.22 CDI80300.1 - 0.15 12.4 0.8 0.31 11.4 0.6 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CDI80300.1 - 0.17 10.9 0.9 0.39 9.7 0.6 1.5 1 0 0 1 1 1 0 FAD binding domain LMBR1 PF04791.11 CDI80301.1 - 6.6 5.2 13.6 46 2.4 9.4 2.1 1 1 0 1 1 1 0 LMBR1-like membrane protein Nnf1 PF03980.9 CDI80305.1 - 0.01 15.8 0.1 0.02 14.8 0.1 1.5 1 0 0 1 1 1 0 Nnf1 Tox-MPTase2 PF15638.1 CDI80305.1 - 0.42 10.0 2.1 0.49 9.8 0.5 1.8 2 1 1 3 3 3 0 Metallopeptidase toxin 2 DUF3378 PF11858.3 CDI80305.1 - 0.91 9.6 5.1 0.17 11.9 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) TPPK_C PF12555.3 CDI80307.1 - 0.91 9.3 3.8 1.3 8.8 2.6 1.4 1 1 0 1 1 1 0 Thiamine pyrophosphokinase C terminal DNA_pol_viral_N PF00242.12 CDI80309.1 - 0.0059 15.6 23.2 0.0087 15.1 16.1 1.4 1 0 0 1 1 1 1 DNA polymerase (viral) N-terminal domain Mem_trans PF03547.13 CDI80309.1 - 0.25 9.5 12.0 0.31 9.2 8.3 1.1 1 0 0 1 1 1 0 Membrane transport protein SLD3 PF08639.5 CDI80309.1 - 0.43 9.1 32.2 0.54 8.8 22.3 1.2 1 0 0 1 1 1 0 DNA replication regulator SLD3 TFIIF_alpha PF05793.7 CDI80309.1 - 1 7.6 38.2 1.7 6.9 26.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Pox_E2-like PF04497.7 CDI80309.1 - 2.7 5.8 4.6 3.8 5.4 3.2 1.2 1 0 0 1 1 1 0 Poxviridae protein Ebola_NP PF05505.7 CDI80309.1 - 8.1 4.3 24.5 11 3.9 17.0 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Hid1 PF12722.2 CDI80309.1 - 8.1 3.9 27.5 11 3.5 19.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2217 PF10265.4 CDI80309.1 - 8.6 4.9 28.5 12 4.5 19.8 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Ribosomal_60s PF00428.14 CDI80311.1 - 0.032 14.6 31.1 0.26 11.7 1.8 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein MyTH4 PF00784.12 CDI80314.1 - 2.1e-15 56.6 3.8 4.8e-15 55.4 1.9 2.0 1 1 1 2 2 2 1 MyTH4 domain NAD_binding_8 PF13450.1 CDI80315.1 - 0.015 15.3 0.0 0.06 13.3 0.0 2.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain YlbD_coat PF14071.1 CDI80315.1 - 8.5 6.4 11.1 1.4 8.9 2.0 2.5 2 0 0 2 2 2 0 Putative coat protein Patatin PF01734.17 CDI80316.1 - 1.5e-28 100.0 4.5 1.5e-28 100.0 3.1 4.6 6 0 0 6 6 6 1 Patatin-like phospholipase Skp1_POZ PF03931.10 CDI80317.1 - 7.9e-08 32.2 0.0 2.3e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF2630 PF10944.3 CDI80317.1 - 0.044 13.8 0.3 0.1 12.7 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2630) Nol1_Nop2_Fmu PF01189.12 CDI80318.1 - 8e-32 110.7 0.0 2.5e-31 109.1 0.0 1.7 1 1 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 CDI80318.1 - 3e-10 39.8 0.0 4.1e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDI80318.1 - 9.2e-10 38.0 0.0 1.3e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CDI80318.1 - 5.2e-07 29.7 0.0 2e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDI80318.1 - 3e-05 23.4 0.0 0.00021 20.7 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CDI80318.1 - 4.3e-05 23.8 0.0 7.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 CDI80318.1 - 0.00035 20.1 0.0 0.0011 18.6 0.0 1.7 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 PCMT PF01135.14 CDI80318.1 - 0.0031 17.0 0.0 0.0047 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 CDI80318.1 - 0.0034 17.9 0.0 0.0069 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.5 CDI80318.1 - 0.014 14.8 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit RrnaAD PF00398.15 CDI80318.1 - 0.049 12.6 0.0 0.074 12.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PASTA PF03793.14 CDI80318.1 - 0.051 13.2 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 PASTA domain Methyltransf_11 PF08241.7 CDI80318.1 - 0.059 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 CDI80318.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) EMP70 PF02990.11 CDI80319.1 - 5.1e-118 394.7 9.3 1.8e-62 211.5 0.0 2.4 1 1 1 2 2 2 2 Endomembrane protein 70 Ribosomal_L14e PF01929.12 CDI80320.1 - 2.4e-29 101.5 5.0 3.1e-29 101.1 3.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 CDI80320.1 - 0.026 14.2 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 KOW motif PPTA PF01239.17 CDI80321.1 - 1.6e-13 49.3 8.9 0.0044 16.3 0.0 4.7 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat Folliculin PF11704.3 CDI80321.1 - 0.03 13.9 0.3 0.03 13.9 0.2 3.1 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport Plasmodium_Vir PF05795.6 CDI80321.1 - 4.6 6.3 22.8 3 6.9 5.3 3.3 3 0 0 3 3 3 0 Plasmodium vivax Vir protein Ycf1 PF05758.7 CDI80322.1 - 0.005 14.6 13.2 0.036 11.7 4.3 2.1 2 0 0 2 2 2 2 Ycf1 Hom_end_hint PF05203.11 CDI80322.1 - 0.27 10.9 4.5 9.8 5.8 2.0 2.4 2 0 0 2 2 2 0 Hom_end-associated Hint AAA_11 PF13086.1 CDI80322.1 - 0.99 8.9 15.2 0.35 10.3 3.7 2.5 2 0 0 2 2 2 0 AAA domain SOBP PF15279.1 CDI80322.1 - 3.1 8.0 15.1 0.62 10.3 6.9 2.0 2 0 0 2 2 2 0 Sine oculis-binding protein SPOUT_MTase PF02590.12 CDI80323.1 - 0.15 11.7 0.9 0.2 11.3 0.2 1.5 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase Cep57_MT_bd PF06657.8 CDI80323.1 - 4.4 7.3 8.9 1.3 9.0 0.1 3.1 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 MFS_1 PF07690.11 CDI80325.1 - 0.00033 19.4 2.5 0.0018 17.0 0.9 2.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2207 PF09972.4 CDI80325.1 - 0.0092 14.6 0.3 0.61 8.6 0.0 2.9 3 0 0 3 3 3 1 Predicted membrane protein (DUF2207) Sugar_tr PF00083.19 CDI80325.1 - 0.026 13.0 1.7 0.099 11.1 0.0 2.3 2 0 0 2 2 2 0 Sugar (and other) transporter OATP PF03137.15 CDI80325.1 - 0.069 11.1 14.9 0.14 10.2 0.0 3.4 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF912 PF06024.7 CDI80325.1 - 0.12 12.4 0.0 0.12 12.4 0.0 5.3 5 1 0 5 5 5 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Peptidase_M50 PF02163.17 CDI80325.1 - 0.17 10.8 0.5 0.27 10.1 0.4 1.4 1 1 0 1 1 1 0 Peptidase family M50 7tm_1 PF00001.16 CDI80325.1 - 5.2 6.1 7.9 2.4 7.2 0.0 2.7 2 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Peroxin-13_N PF04088.8 CDI80325.1 - 6.8 6.6 18.4 2.1 8.2 0.7 3.9 4 0 0 4 4 4 0 Peroxin 13, N-terminal region Plasmodium_Vir PF05795.6 CDI80325.1 - 8.1 5.5 23.0 0.024 13.8 3.7 2.7 2 1 0 2 2 2 0 Plasmodium vivax Vir protein UQ_con PF00179.21 CDI80327.1 - 6.2e-45 152.0 0.0 7.1e-45 151.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDI80327.1 - 0.0023 17.6 0.0 0.004 16.9 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDI80327.1 - 0.0046 16.8 0.0 0.0061 16.4 0.0 1.4 1 0 0 1 1 1 1 RWD domain UFC1 PF08694.6 CDI80327.1 - 0.011 15.1 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Val_tRNA-synt_C PF10458.4 CDI80327.1 - 0.15 12.1 2.5 0.34 11.0 1.8 1.5 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Shadoo PF14999.1 CDI80329.1 - 0.034 13.9 5.5 0.084 12.7 3.2 2.0 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Dehalogenase PF13486.1 CDI80329.1 - 0.18 11.2 5.5 0.059 12.8 1.4 1.9 2 0 0 2 2 2 0 Reductive dehalogenase subunit DNA_ligase_A_N PF04675.9 CDI80332.1 - 9.1e-11 41.8 0.0 9.1e-11 41.8 0.0 2.4 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_M PF01068.16 CDI80332.1 - 8.8e-08 31.7 0.0 2.9e-06 26.7 0.0 2.5 2 0 0 2 2 2 1 ATP dependent DNA ligase domain SR-25 PF10500.4 CDI80332.1 - 0.00012 21.6 5.2 0.00012 21.6 3.6 6.9 3 2 1 5 5 5 1 Nuclear RNA-splicing-associated protein Herpes_UL3 PF03369.8 CDI80333.1 - 7.3 6.5 6.8 10 6.0 0.0 2.5 3 0 0 3 3 3 0 Herpesvirus UL3 protein Glutaredoxin PF00462.19 CDI80334.1 - 1.6e-06 27.9 0.3 0.0024 17.8 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin DUF342 PF03961.8 CDI80334.1 - 1.8e-06 26.6 9.5 2e-06 26.5 6.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Vfa1 PF08432.5 CDI80334.1 - 0.0014 18.6 8.7 0.0016 18.5 6.0 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 ZYG-11_interact PF05884.7 CDI80334.1 - 0.0051 15.9 8.5 0.0073 15.4 5.9 1.3 1 0 0 1 1 1 1 Interactor of ZYG-11 GvpL_GvpF PF06386.6 CDI80334.1 - 0.0065 16.0 13.3 0.0077 15.8 9.2 1.2 1 0 0 1 1 1 1 Gas vesicle synthesis protein GvpL/GvpF DASH_Spc19 PF08287.6 CDI80334.1 - 0.0074 15.9 24.1 0.011 15.4 16.7 1.2 1 0 0 1 1 1 1 Spc19 Striatin PF08232.7 CDI80334.1 - 0.0079 16.5 15.7 0.013 15.8 10.9 1.4 1 0 0 1 1 1 1 Striatin family Ran-binding PF05508.6 CDI80334.1 - 0.017 14.0 9.1 0.024 13.5 5.8 1.5 1 1 0 1 1 1 0 RanGTP-binding protein Methyltransf_12 PF08242.7 CDI80334.1 - 0.019 15.3 2.0 0.071 13.5 1.4 2.0 1 1 0 1 1 1 0 Methyltransferase domain DUF4407 PF14362.1 CDI80334.1 - 0.021 13.7 20.5 0.031 13.2 14.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAPS PF04499.10 CDI80334.1 - 0.046 12.3 10.0 0.053 12.1 7.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein V_ATPase_I PF01496.14 CDI80334.1 - 0.051 11.4 10.5 0.053 11.3 7.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TAP42 PF04177.7 CDI80334.1 - 0.051 12.5 17.5 0.066 12.1 12.1 1.1 1 0 0 1 1 1 0 TAP42-like family Rtf2 PF04641.7 CDI80334.1 - 0.054 12.6 11.4 0.062 12.4 7.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Exonuc_VII_L PF02601.10 CDI80334.1 - 0.059 12.5 17.3 0.07 12.3 12.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.7 CDI80334.1 - 0.063 11.7 13.8 0.063 11.7 9.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family SpaB_C PF14028.1 CDI80334.1 - 0.076 12.5 4.5 0.085 12.3 3.1 1.1 1 0 0 1 1 1 0 SpaB C-terminal domain BTV_NS2 PF04514.7 CDI80334.1 - 0.11 11.3 9.9 0.14 10.9 6.9 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 LMBR1 PF04791.11 CDI80334.1 - 0.13 10.7 9.1 0.15 10.6 6.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Mnd1 PF03962.10 CDI80334.1 - 0.16 11.6 25.2 0.27 10.8 17.4 1.4 1 0 0 1 1 1 0 Mnd1 family Ndc1_Nup PF09531.5 CDI80334.1 - 0.16 10.3 9.3 0.17 10.2 6.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup APG6 PF04111.7 CDI80334.1 - 0.18 10.8 24.0 0.26 10.2 16.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 PAT1 PF09770.4 CDI80334.1 - 0.22 9.7 39.2 0.25 9.5 27.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cob_adeno_trans PF01923.13 CDI80334.1 - 0.23 11.2 8.8 0.33 10.7 6.1 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF3584 PF12128.3 CDI80334.1 - 0.23 8.7 27.8 0.28 8.4 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) eIF-3_zeta PF05091.7 CDI80334.1 - 0.24 9.9 16.9 0.3 9.6 11.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Utp11 PF03998.8 CDI80334.1 - 0.24 11.1 20.8 0.33 10.7 14.4 1.2 1 0 0 1 1 1 0 Utp11 protein SID-1_RNA_chan PF13965.1 CDI80334.1 - 0.24 9.5 8.2 0.27 9.3 5.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Trehalase PF01204.13 CDI80334.1 - 0.24 9.9 8.2 0.27 9.8 5.7 1.1 1 0 0 1 1 1 0 Trehalase GAGA_bind PF06217.7 CDI80334.1 - 0.26 11.2 10.5 0.31 10.9 7.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Flagellar_rod PF05149.7 CDI80334.1 - 0.27 10.3 29.9 0.41 9.7 20.7 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein Baculo_p24 PF05073.7 CDI80334.1 - 0.3 10.6 11.3 0.44 10.0 7.8 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein DUF3595 PF12166.3 CDI80334.1 - 0.31 9.8 8.7 0.31 9.8 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) Ycf1 PF05758.7 CDI80334.1 - 0.32 8.6 12.2 0.33 8.6 8.4 1.0 1 0 0 1 1 1 0 Ycf1 AIF_C PF14721.1 CDI80334.1 - 0.33 11.1 6.5 0.48 10.6 4.5 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4045 PF13254.1 CDI80334.1 - 0.34 10.1 10.1 0.41 9.8 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) FemAB PF02388.11 CDI80334.1 - 0.37 9.4 18.2 0.53 8.8 12.6 1.2 1 0 0 1 1 1 0 FemAB family Amidase PF01425.16 CDI80334.1 - 0.38 9.5 1.7 0.46 9.2 1.2 1.1 1 0 0 1 1 1 0 Amidase RR_TM4-6 PF06459.7 CDI80334.1 - 0.39 10.5 11.9 0.47 10.2 8.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MRP-S27 PF10037.4 CDI80334.1 - 0.4 9.5 16.3 0.44 9.4 11.3 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF1501 PF07394.7 CDI80334.1 - 0.42 9.4 12.4 0.46 9.2 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) SPX PF03105.14 CDI80334.1 - 0.42 10.3 11.7 0.49 10.1 8.1 1.2 1 0 0 1 1 1 0 SPX domain Hid1 PF12722.2 CDI80334.1 - 0.46 8.0 10.4 0.48 8.0 7.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ctr PF04145.10 CDI80334.1 - 0.49 10.4 7.6 0.66 10.0 5.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DNA_pack_N PF02500.10 CDI80334.1 - 0.6 9.5 8.2 0.87 9.0 5.7 1.2 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus DUF1840 PF08895.6 CDI80334.1 - 0.74 9.8 16.9 2 8.5 11.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) Neur_chan_memb PF02932.11 CDI80334.1 - 0.8 9.5 7.5 0.93 9.3 5.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Atg14 PF10186.4 CDI80334.1 - 0.83 8.5 29.1 1.3 7.8 20.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Laminin_II PF06009.7 CDI80334.1 - 0.93 9.2 17.2 1.5 8.5 11.9 1.3 1 0 0 1 1 1 0 Laminin Domain II Peptidase_S15 PF02129.13 CDI80334.1 - 1 8.7 9.6 1.4 8.3 6.7 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1631 PF07793.6 CDI80334.1 - 1.1 7.3 28.5 1.3 7.0 19.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) DUF4613 PF15390.1 CDI80334.1 - 1.2 7.2 15.3 1.5 6.9 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Dynactin_p62 PF05502.8 CDI80334.1 - 1.3 7.7 13.7 1.4 7.6 9.5 1.1 1 0 0 1 1 1 0 Dynactin p62 family YjgP_YjgQ PF03739.9 CDI80334.1 - 1.3 7.7 8.2 1.5 7.5 5.7 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Phlebovirus_NSM PF07246.6 CDI80334.1 - 1.4 7.9 7.6 1.7 7.7 5.3 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Band_3_cyto PF07565.8 CDI80334.1 - 1.6 8.2 12.2 2 7.8 8.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TerB-C PF15615.1 CDI80334.1 - 1.7 8.8 11.7 3.2 7.9 8.1 1.5 1 0 0 1 1 1 0 TerB-C domain Peptidase_S46 PF10459.4 CDI80334.1 - 1.7 6.9 11.7 1.8 6.8 8.1 1.1 1 0 0 1 1 1 0 Peptidase S46 MMPL PF03176.10 CDI80334.1 - 1.8 7.1 9.2 2.2 6.9 6.4 1.2 1 0 0 1 1 1 0 MMPL family DUF87 PF01935.12 CDI80334.1 - 1.9 8.2 5.4 2 8.1 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 7tm_7 PF08395.7 CDI80334.1 - 1.9 7.4 14.9 2.8 6.8 10.3 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor DUF2828 PF11443.3 CDI80334.1 - 2 6.5 10.6 2.3 6.3 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TMV_coat PF00721.16 CDI80334.1 - 2.1 8.2 11.1 3.7 7.4 7.4 1.6 1 1 1 2 2 2 0 Virus coat protein (TMV like) DDHD PF02862.12 CDI80334.1 - 2.2 7.9 13.7 2.9 7.6 9.5 1.2 1 0 0 1 1 1 0 DDHD domain Spore_YhcN_YlaJ PF09580.5 CDI80334.1 - 2.3 8.3 13.2 3.1 7.8 9.1 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AAA_13 PF13166.1 CDI80334.1 - 2.4 6.5 17.4 3.2 6.0 12.1 1.1 1 0 0 1 1 1 0 AAA domain EIIBC-GUT_N PF03612.9 CDI80334.1 - 2.7 7.5 10.5 3.9 7.0 7.3 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TFIIA PF03153.8 CDI80334.1 - 2.9 7.6 30.4 3.4 7.4 21.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Prominin PF05478.6 CDI80334.1 - 3 5.2 15.3 3.7 4.9 10.6 1.1 1 0 0 1 1 1 0 Prominin YicC_N PF03755.8 CDI80334.1 - 3.3 7.6 13.0 4.9 7.0 9.0 1.3 1 0 0 1 1 1 0 YicC-like family, N-terminal region DUF3708 PF12501.3 CDI80334.1 - 3.4 7.4 8.3 5.8 6.7 5.7 1.4 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter PCYCGC PF13798.1 CDI80334.1 - 3.5 7.3 8.7 4.9 6.8 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif Sec62 PF03839.11 CDI80334.1 - 3.6 6.9 10.2 4.4 6.6 7.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 CPSF100_C PF13299.1 CDI80334.1 - 3.8 7.6 13.3 5.4 7.1 9.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SprA-related PF12118.3 CDI80334.1 - 3.8 6.7 39.8 5.9 6.1 27.6 1.3 1 0 0 1 1 1 0 SprA-related family RGS-like PF09128.6 CDI80334.1 - 3.9 6.9 17.0 5.8 6.3 11.8 1.3 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain HemX PF04375.9 CDI80334.1 - 3.9 5.9 40.1 4.6 5.7 26.8 1.7 1 1 1 2 2 2 0 HemX Paramyxo_ncap PF00973.14 CDI80334.1 - 3.9 6.0 10.9 4.5 5.8 7.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Cons_hypoth95 PF03602.10 CDI80334.1 - 3.9 6.8 10.9 0.22 10.8 2.4 2.0 1 1 1 2 2 2 0 Conserved hypothetical protein 95 UPF0565 PF10561.4 CDI80334.1 - 4.2 6.1 9.8 5.2 5.8 6.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DUF1800 PF08811.6 CDI80334.1 - 4.4 6.1 21.0 5.3 5.8 14.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) Adaptin_binding PF10199.4 CDI80334.1 - 4.5 7.5 25.3 0.13 12.5 13.2 1.6 2 0 0 2 2 1 0 Alpha and gamma adaptin binding protein p34 DUF2347 PF09804.4 CDI80334.1 - 5 6.3 9.3 6.4 5.9 6.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) HlyD_2 PF12700.2 CDI80334.1 - 5.3 6.0 15.7 6.6 5.7 10.9 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Fic PF02661.13 CDI80334.1 - 5.7 7.7 6.3 9.9 6.9 4.3 1.5 1 0 0 1 1 1 0 Fic/DOC family DUF3287 PF11690.3 CDI80334.1 - 5.9 7.0 17.0 2.3 8.2 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) FAM176 PF14851.1 CDI80334.1 - 8.1 6.1 7.7 12 5.5 5.4 1.3 1 0 0 1 1 1 0 FAM176 family DUF607 PF04678.8 CDI80334.1 - 8.3 6.3 18.3 0.36 10.7 3.9 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF607 Folate_carrier PF01770.13 CDI80334.1 - 8.4 4.7 9.2 9.7 4.5 6.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF1943 PF09172.6 CDI80334.1 - 8.6 5.1 12.7 12 4.6 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Glyco_transf_15 PF01793.11 CDI80334.1 - 8.8 5.1 11.0 12 4.7 7.6 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase FAM222A PF15258.1 CDI80334.1 - 9.2 5.3 24.1 12 4.9 16.7 1.2 1 0 0 1 1 1 0 Protein family of FAM222A Fmp27_WPPW PF10359.4 CDI80334.1 - 9.5 4.5 20.0 13 4.1 13.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain FAM60A PF15396.1 CDI80334.1 - 9.8 5.8 10.1 12 5.5 7.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SprA-related PF12118.3 CDI80336.1 - 0.014 14.7 22.9 0.019 14.3 15.9 1.2 1 0 0 1 1 1 0 SprA-related family DUF1796 PF08795.5 CDI80336.1 - 0.042 13.4 0.9 0.066 12.8 0.6 1.3 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) AAA_23 PF13476.1 CDI80336.1 - 0.048 13.9 8.6 0.064 13.5 5.9 1.3 1 0 0 1 1 1 0 AAA domain DUF605 PF04652.11 CDI80336.1 - 0.27 10.5 16.1 0.32 10.3 11.2 1.1 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 CDI80336.1 - 0.63 9.8 19.3 0.81 9.5 13.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOBP PF15279.1 CDI80336.1 - 0.99 9.7 17.2 1.2 9.4 11.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein RAP1 PF07218.6 CDI80336.1 - 1.1 7.2 4.2 1.2 7.1 2.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3464 PF11947.3 CDI80336.1 - 7.4 6.0 14.2 47 3.4 9.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3464) NAD_binding_8 PF13450.1 CDI80338.1 - 7.4e-08 32.3 9.2 0.00028 20.8 0.0 3.6 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CDI80338.1 - 0.0016 17.5 0.1 0.0088 15.1 0.0 2.2 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase BTG PF07742.7 CDI80338.1 - 0.052 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 BTG family RRM_1 PF00076.17 CDI80339.1 - 2.4e-21 75.1 0.0 9.5e-12 44.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80339.1 - 4.9e-15 55.1 0.1 1.7e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80339.1 - 1.7e-11 43.9 0.0 0.00022 21.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF3306 PF11748.3 CDI80339.1 - 0.11 13.1 2.1 0.22 12.1 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Limkain-b1 PF11608.3 CDI80339.1 - 0.15 11.8 0.0 0.78 9.5 0.0 2.1 2 0 0 2 2 2 0 Limkain b1 APC_CDC26 PF10471.4 CDI80339.1 - 0.18 12.5 6.5 0.47 11.2 4.5 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 Pkinase PF00069.20 CDI80341.1 - 1.1e-50 172.1 0.0 1.6e-50 171.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80341.1 - 1.2e-21 76.9 0.0 1.7e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI80341.1 - 4.8e-07 29.0 0.0 1e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.19 CDI80341.1 - 0.0071 16.8 0.7 0.022 15.2 0.5 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain VPR PF00522.13 CDI80341.1 - 0.077 12.8 0.0 0.58 9.9 0.0 2.1 2 0 0 2 2 2 0 VPR/VPX protein Pkinase PF00069.20 CDI80343.1 - 3.4e-46 157.5 0.0 6.5e-30 104.1 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80343.1 - 1.6e-23 83.1 0.0 3.7e-16 58.9 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase DUF3818 PF12825.2 CDI80345.1 - 0.03 12.9 0.3 0.051 12.2 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) PUF PF00806.14 CDI80345.1 - 0.033 13.6 0.1 0.089 12.3 0.0 1.8 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat RPA_C PF08784.6 CDI80345.1 - 8.2 6.9 7.7 5.7 7.4 0.1 2.7 2 1 0 2 2 2 0 Replication protein A C terminal Vps51 PF08700.6 CDI80346.1 - 4.9e-17 61.5 0.6 4.9e-17 61.5 0.4 2.8 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.1 CDI80346.1 - 3.1e-06 27.0 1.3 1.1e-05 25.2 0.9 2.0 1 0 0 1 1 1 1 Exocyst complex component Sec5 COG2 PF06148.6 CDI80346.1 - 5.7e-06 26.2 0.3 5.7e-06 26.2 0.2 3.0 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 ACTH_domain PF00976.13 CDI80346.1 - 0.11 12.3 0.5 0.28 11.0 0.3 1.7 1 0 0 1 1 1 0 Corticotropin ACTH domain ABC_tran PF00005.22 CDI80347.1 - 2.4e-14 53.7 0.8 8.2e-10 39.1 0.0 3.9 3 1 0 3 3 3 2 ABC transporter ABC_membrane PF00664.18 CDI80347.1 - 2.8e-11 43.3 2.8 9.9e-06 25.1 0.3 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_19 PF13245.1 CDI80347.1 - 0.00019 21.1 1.3 0.00019 21.1 0.9 3.1 2 1 1 3 3 3 1 Part of AAA domain AAA_16 PF13191.1 CDI80347.1 - 0.0002 21.4 0.1 0.0002 21.4 0.1 2.8 3 0 0 3 3 1 1 AAA ATPase domain AAA_29 PF13555.1 CDI80347.1 - 0.00067 19.1 0.1 0.002 17.6 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_11 PF13086.1 CDI80347.1 - 0.0024 17.4 12.4 0.18 11.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.1 CDI80347.1 - 0.0039 16.6 0.1 0.011 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 CDI80347.1 - 0.0042 16.0 0.0 0.0086 15.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF3408 PF11888.3 CDI80347.1 - 0.0076 16.1 2.2 0.0076 16.1 1.6 4.1 5 0 0 5 5 3 1 Protein of unknown function (DUF3408) NTPase_1 PF03266.10 CDI80347.1 - 0.01 15.5 0.2 0.027 14.1 0.1 1.7 1 0 0 1 1 1 0 NTPase cobW PF02492.14 CDI80347.1 - 0.013 14.9 0.1 0.027 13.9 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 CDI80347.1 - 0.022 14.9 0.0 0.06 13.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI80347.1 - 0.023 14.8 0.0 0.089 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CDI80347.1 - 0.037 14.8 0.4 0.037 14.8 0.3 2.4 2 0 0 2 2 1 0 AAA domain KaiC PF06745.8 CDI80347.1 - 0.043 12.9 0.1 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.1 CDI80347.1 - 0.046 13.3 0.2 0.046 13.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain GvpD PF07088.6 CDI80347.1 - 0.11 10.7 0.0 0.19 10.0 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein NACHT PF05729.7 CDI80347.1 - 0.13 11.9 1.5 0.27 10.8 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.1 CDI80347.1 - 0.16 12.3 0.1 0.16 12.3 0.1 2.8 2 1 1 3 3 1 0 AAA domain AAA_33 PF13671.1 CDI80347.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.7 2 0 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.13 CDI80347.1 - 0.56 9.6 2.9 0.35 10.3 0.1 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ArgK PF03308.11 CDI80347.1 - 1.1 7.9 4.5 0.18 10.5 0.0 1.9 2 0 0 2 2 1 0 ArgK protein DUF4366 PF14283.1 CDI80347.1 - 1.3 8.3 19.9 0.012 15.0 6.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) G-alpha PF00503.15 CDI80347.1 - 1.8 7.1 10.9 12 4.4 6.3 2.5 2 0 0 2 2 2 0 G-protein alpha subunit BAF1_ABF1 PF04684.8 CDI80347.1 - 2.7 6.7 23.1 0.28 9.9 7.6 2.4 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor AAA PF00004.24 CDI80348.1 - 3.6e-42 143.6 0.0 6.8e-42 142.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 CDI80348.1 - 2.4e-07 30.8 0.0 7.1e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CDI80348.1 - 3.3e-06 27.2 0.1 0.00017 21.6 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 CDI80348.1 - 4.7e-06 26.7 0.3 0.0031 17.6 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 CDI80348.1 - 5.3e-06 26.1 0.1 7.7e-05 22.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CDI80348.1 - 1.6e-05 24.1 0.0 3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 CDI80348.1 - 0.00045 19.6 0.0 0.00096 18.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 CDI80348.1 - 0.0012 17.6 0.0 0.0021 16.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus Sigma54_activat PF00158.21 CDI80348.1 - 0.0013 18.2 0.1 0.0049 16.3 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain RNA_helicase PF00910.17 CDI80348.1 - 0.002 18.2 0.0 0.0045 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.1 CDI80348.1 - 0.0021 17.9 0.0 0.031 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CDI80348.1 - 0.0023 17.0 0.0 0.0048 16.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 CDI80348.1 - 0.0026 17.6 0.0 0.0057 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 CDI80348.1 - 0.0032 16.6 0.0 0.0061 15.7 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 CDI80348.1 - 0.0034 17.1 0.2 0.011 15.5 0.0 1.9 2 0 0 2 2 1 1 Part of AAA domain AAA_17 PF13207.1 CDI80348.1 - 0.0034 18.1 0.1 0.014 16.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CDI80348.1 - 0.0047 16.3 0.1 0.023 14.1 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 CDI80348.1 - 0.0053 17.0 0.0 0.031 14.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain PhoH PF02562.11 CDI80348.1 - 0.0065 15.7 0.0 0.014 14.6 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein DUF815 PF05673.8 CDI80348.1 - 0.0075 15.2 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_3 PF07726.6 CDI80348.1 - 0.0078 15.8 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 CDI80348.1 - 0.012 15.6 0.1 0.031 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 CDI80348.1 - 0.013 15.0 0.1 0.026 14.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 CDI80348.1 - 0.014 15.4 0.0 0.044 13.8 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.1 CDI80348.1 - 0.024 14.2 0.5 0.14 11.6 0.0 2.3 2 2 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 CDI80348.1 - 0.024 13.4 0.0 0.042 12.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 KaiC PF06745.8 CDI80348.1 - 0.027 13.5 0.0 0.072 12.1 0.0 1.7 2 0 0 2 2 2 0 KaiC SKI PF01202.17 CDI80348.1 - 0.028 14.2 0.4 0.53 10.1 0.0 2.6 2 1 1 3 3 3 0 Shikimate kinase Arch_ATPase PF01637.13 CDI80348.1 - 0.03 14.0 0.1 0.21 11.2 0.0 2.4 2 1 1 3 3 3 0 Archaeal ATPase NACHT PF05729.7 CDI80348.1 - 0.031 13.9 0.1 0.19 11.3 0.0 2.2 1 1 0 2 2 2 0 NACHT domain UPF0079 PF02367.12 CDI80348.1 - 0.036 13.7 0.4 0.068 12.7 0.0 1.6 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 UMP1 PF05348.6 CDI80349.1 - 1.8e-11 44.1 0.0 2.1e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 DHHA1 PF02272.14 CDI80349.1 - 0.67 9.6 4.2 0.8 9.4 2.1 1.7 1 1 0 1 1 1 0 DHHA1 domain Aldedh PF00171.17 CDI80350.1 - 0.00043 18.7 0.6 0.42 8.8 0.1 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Rdx PF10262.4 CDI80352.1 - 0.00053 19.9 0.0 0.00055 19.9 0.0 1.2 1 0 0 1 1 1 1 Rdx family ODV-E18 PF10717.4 CDI80352.1 - 0.017 14.5 0.1 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF3357 PF11837.3 CDI80352.1 - 0.054 13.3 0.3 0.086 12.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Hid1 PF12722.2 CDI80353.1 - 0.03 12.0 22.1 0.041 11.5 15.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.9 CDI80353.1 - 0.11 10.5 22.1 0.17 9.8 15.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Phage_gp49_66 PF13876.1 CDI80353.1 - 0.17 12.0 1.4 11 6.1 0.7 2.4 2 0 0 2 2 2 0 Phage protein (N4 Gp49/phage Sf6 gene 66) family Mem_trans PF03547.13 CDI80353.1 - 0.18 10.0 7.8 0.27 9.5 5.4 1.2 1 0 0 1 1 1 0 Membrane transport protein DUF2146 PF10220.4 CDI80353.1 - 2.3 6.1 20.3 3.5 5.4 14.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Ndc1_Nup PF09531.5 CDI80353.1 - 3.6 5.8 24.9 7.2 4.9 17.2 1.5 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RasGAP PF00616.14 CDI80357.1 - 0.017 14.8 3.3 0.019 14.5 2.3 1.0 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase PAT1 PF09770.4 CDI80357.1 - 0.021 13.0 7.8 0.023 12.9 5.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Rsc14 PF08586.5 CDI80357.1 - 0.031 14.7 2.1 0.036 14.5 1.4 1.1 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit DUF788 PF05620.6 CDI80357.1 - 0.035 13.9 3.5 0.045 13.6 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF788) LAM_C PF12544.3 CDI80357.1 - 0.093 12.7 1.7 0.12 12.4 1.2 1.1 1 0 0 1 1 1 0 Lysine-2,3-aminomutase CMS1 PF14617.1 CDI80357.1 - 0.098 11.7 1.0 0.11 11.5 0.7 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit FimP PF09766.4 CDI80357.1 - 0.12 11.4 7.6 0.12 11.4 5.3 1.0 1 0 0 1 1 1 0 Fms-interacting protein ERF PF04404.7 CDI80357.1 - 0.12 11.8 7.1 0.12 11.9 4.9 1.1 1 0 0 1 1 1 0 ERF superfamily Serinc PF03348.10 CDI80357.1 - 0.2 10.3 3.4 0.23 10.1 2.3 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF106 PF01956.11 CDI80357.1 - 0.24 10.9 1.3 0.23 10.9 0.9 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF2422 PF10337.4 CDI80357.1 - 0.25 10.0 2.7 0.26 10.0 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) OATP PF03137.15 CDI80357.1 - 0.27 9.2 1.7 0.27 9.2 1.2 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Spt20 PF12090.3 CDI80357.1 - 0.31 10.3 5.3 0.33 10.2 3.6 1.1 1 0 0 1 1 1 0 Spt20 family Med15 PF09606.5 CDI80357.1 - 0.33 9.1 15.5 0.35 9.0 10.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI80357.1 - 0.38 9.4 16.1 0.37 9.4 11.2 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3947 PF13135.1 CDI80357.1 - 0.43 10.8 8.0 0.48 10.6 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) YjgP_YjgQ PF03739.9 CDI80357.1 - 0.53 8.9 2.6 0.61 8.7 1.8 1.0 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family zf-DHHC PF01529.15 CDI80357.1 - 0.54 9.6 2.6 0.62 9.4 1.8 1.0 1 0 0 1 1 1 0 DHHC palmitoyltransferase IncA PF04156.9 CDI80357.1 - 0.59 9.7 10.3 0.63 9.5 7.1 1.0 1 0 0 1 1 1 0 IncA protein BAF1_ABF1 PF04684.8 CDI80357.1 - 0.68 8.7 9.3 0.68 8.7 6.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4199 PF13858.1 CDI80357.1 - 0.86 9.5 2.6 0.89 9.4 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) SprA-related PF12118.3 CDI80357.1 - 1.1 8.5 14.0 1.2 8.4 9.7 1.0 1 0 0 1 1 1 0 SprA-related family Suf PF05843.9 CDI80357.1 - 1.1 8.8 6.2 1.2 8.8 4.3 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4557 PF15101.1 CDI80357.1 - 1.1 9.0 7.7 1.2 8.9 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF3464 PF11947.3 CDI80357.1 - 1.4 8.3 3.7 1.5 8.2 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) RAB3GAP2_N PF14655.1 CDI80357.1 - 1.4 7.8 5.6 1.5 7.7 3.9 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4175 PF13779.1 CDI80357.1 - 1.9 6.0 13.2 1.9 6.1 9.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SHR3_chaperone PF08229.6 CDI80357.1 - 9.3 5.1 6.6 9.9 5.0 4.6 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 Hid1 PF12722.2 CDI80358.1 - 0.65 7.6 7.4 1.4 6.4 5.2 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BRF1 PF07741.8 CDI80358.1 - 5.7 7.2 14.8 7.9 6.7 6.1 3.9 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF3839 PF12943.2 CDI80359.1 - 0.024 13.8 0.9 0.055 12.6 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3839) Spore_coat_CotO PF14153.1 CDI80359.1 - 0.096 12.1 34.0 0.22 10.9 12.0 2.4 2 0 0 2 2 2 0 Spore coat protein CotO Na_trans_assoc PF06512.8 CDI80359.1 - 0.12 12.3 16.8 0.18 11.7 5.3 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated PAT1 PF09770.4 CDI80359.1 - 0.3 9.2 66.1 0.097 10.9 27.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI80359.1 - 0.47 8.5 88.5 0.042 12.0 35.1 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal FLO_LFY PF01698.11 CDI80359.1 - 1 8.1 17.1 2.2 7.0 6.6 2.3 2 0 0 2 2 2 0 Floricaula / Leafy protein DUF1510 PF07423.6 CDI80359.1 - 1.6 8.0 30.5 2.3 7.5 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Hid1 PF12722.2 CDI80359.1 - 1.8 6.1 28.5 0.25 9.0 12.1 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Afaf PF15339.1 CDI80359.1 - 2.3 7.7 11.6 0.24 10.9 1.7 2.5 2 1 0 2 2 2 0 Acrosome formation-associated factor DUF1943 PF09172.6 CDI80359.1 - 2.3 6.9 19.0 0.21 10.4 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) AAA_23 PF13476.1 CDI80359.1 - 2.4 8.4 39.3 0.11 12.8 4.4 2.3 2 0 0 2 2 2 0 AAA domain DUF4647 PF15504.1 CDI80359.1 - 3.2 6.5 29.3 1.5 7.5 11.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) RNF111_N PF15303.1 CDI80359.1 - 4.7 6.6 28.7 0.33 10.4 12.4 2.4 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus Lin-8 PF03353.10 CDI80359.1 - 5.4 6.1 30.4 0.6 9.3 10.8 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MAT1 PF06391.8 CDI80359.1 - 6.6 6.2 38.2 4.9 6.6 13.7 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Rtf2 PF04641.7 CDI80359.1 - 7.9 5.6 25.2 5 6.2 10.5 2.3 2 0 0 2 2 2 0 Rtf2 RING-finger Ycf1 PF05758.7 CDI80359.1 - 8.1 4.0 26.4 0.42 8.2 8.2 2.0 2 0 0 2 2 2 0 Ycf1 GHMP_kinases_N PF00288.21 CDI80359.1 - 9.2 6.4 13.3 41 4.3 6.1 3.0 3 0 0 3 3 3 0 GHMP kinases N terminal domain tRNA-synt_1 PF00133.17 CDI80360.1 - 2.4e-27 95.2 9.8 3e-17 61.8 0.0 7.3 7 1 1 8 8 8 5 tRNA synthetases class I (I, L, M and V) Activator_LAG-3 PF11498.3 CDI80361.1 - 0.0028 16.4 28.2 0.0028 16.4 19.6 3.9 2 1 0 3 3 3 1 Transcriptional activator LAG-3 Phostensin_N PF13916.1 CDI80361.1 - 0.012 15.5 1.0 0.012 15.5 0.7 5.0 3 2 1 4 4 4 0 PP1-regulatory protein, Phostensin N-terminal SMC_hinge PF06470.8 CDI80362.1 - 2.6e-12 46.7 0.0 2.6e-12 46.7 0.0 4.5 5 1 1 6 6 6 1 SMC proteins Flexible Hinge Domain Reo_sigmaC PF04582.7 CDI80362.1 - 0.0027 16.9 7.1 0.0027 16.9 4.9 4.9 2 2 3 5 5 5 2 Reovirus sigma C capsid protein Ribosomal_60s PF00428.14 CDI80362.1 - 0.0053 17.1 12.4 0.0053 17.1 8.6 7.0 6 2 2 8 8 8 1 60s Acidic ribosomal protein SMC_N PF02463.14 CDI80362.1 - 0.045 12.9 0.1 0.045 12.9 0.1 4.8 2 2 2 4 4 4 0 RecF/RecN/SMC N terminal domain Macoilin PF09726.4 CDI80366.1 - 0.024 12.9 24.6 0.038 12.2 17.1 1.3 1 0 0 1 1 1 0 Transmembrane protein Spc7_N PF15402.1 CDI80366.1 - 0.4 8.6 28.7 0.56 8.1 19.9 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Hex_IIIa PF02455.11 CDI80366.1 - 0.92 8.1 10.7 1.1 7.9 7.4 1.3 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) IncA PF04156.9 CDI80367.1 - 0.0035 16.9 14.5 0.0035 16.9 10.1 9.3 6 2 1 7 7 7 1 IncA protein Haem_oxygenas_2 PF14518.1 CDI80367.1 - 0.18 11.9 1.5 0.9 9.7 0.0 3.1 3 0 0 3 3 3 0 Iron-containing redox enzyme Thymidylat_synt PF00303.14 CDI80368.1 - 4e-45 153.9 0.1 6.5e-42 143.4 0.0 2.8 3 1 1 4 4 4 2 Thymidylate synthase DHFR_1 PF00186.14 CDI80368.1 - 3.3e-06 26.7 0.3 3.3e-06 26.7 0.2 2.1 2 0 0 2 2 2 1 Dihydrofolate reductase DNA_pol3_a_NII PF11490.3 CDI80368.1 - 0.013 15.1 1.6 0.013 15.1 1.1 3.3 2 1 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Scs3p PF10261.4 CDI80368.1 - 0.19 10.7 2.2 0.39 9.7 1.5 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Tubulin_2 PF13809.1 CDI80368.1 - 0.24 10.2 9.4 0.37 9.7 6.5 1.2 1 0 0 1 1 1 0 Tubulin like ATG22 PF11700.3 CDI80368.1 - 0.61 8.5 3.9 0.15 10.5 0.1 1.6 1 1 0 2 2 2 0 Vacuole effluxer Atg22 like TFIIA PF03153.8 CDI80368.1 - 0.79 9.5 29.6 1.3 8.7 20.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Herpes_UL87 PF03043.9 CDI80368.1 - 0.83 7.9 9.2 1.1 7.5 6.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family Ribosomal_60s PF00428.14 CDI80368.1 - 4.1 7.8 13.9 11 6.5 9.6 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Tau95 PF09734.4 CDI80368.1 - 5 6.3 13.7 7.3 5.8 9.5 1.1 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit VitK2_biosynth PF02621.9 CDI80371.1 - 0.2 10.7 4.7 0.27 10.4 3.2 1.2 1 0 0 1 1 1 0 Menaquinone biosynthesis ALMT PF11744.3 CDI80371.1 - 0.24 10.0 1.7 0.26 9.9 1.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3708 PF12501.3 CDI80371.1 - 0.28 10.9 2.7 0.38 10.5 1.9 1.2 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter DOG1 PF14144.1 CDI80371.1 - 0.42 10.6 4.9 7 6.7 1.2 2.1 1 1 1 2 2 2 0 Seed dormancy control RRF PF01765.14 CDI80371.1 - 0.57 9.6 9.9 0.67 9.4 6.9 1.1 1 0 0 1 1 1 0 Ribosome recycling factor Perilipin PF03036.11 CDI80371.1 - 0.6 8.8 7.9 0.71 8.6 5.5 1.0 1 0 0 1 1 1 0 Perilipin family Peptidase_C50 PF03568.12 CDI80371.1 - 0.92 8.1 4.4 1.3 7.6 3.1 1.3 1 1 0 1 1 1 0 Peptidase family C50 Histidinol_dh PF00815.15 CDI80371.1 - 1 7.9 4.2 1.2 7.7 2.9 1.1 1 0 0 1 1 1 0 Histidinol dehydrogenase DUF2229 PF09989.4 CDI80371.1 - 2.3 7.6 6.4 3.7 6.9 4.5 1.4 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF2317 PF10079.4 CDI80371.1 - 8.4 4.8 12.4 9.3 4.7 8.6 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) Nol1_Nop2_Fmu PF01189.12 CDI80372.1 - 2.5e-13 50.0 0.0 1.9e-06 27.4 0.0 2.7 3 0 0 3 3 3 2 NOL1/NOP2/sun family FtsJ PF01728.14 CDI80372.1 - 0.043 13.8 0.1 0.21 11.5 0.1 1.9 1 1 0 1 1 1 0 FtsJ-like methyltransferase Prismane PF03063.15 CDI80372.1 - 0.081 11.2 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family BTB_2 PF02214.17 CDI80374.1 - 8e-14 51.6 0.1 2e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain SNF2_N PF00176.18 CDI80374.1 - 0.27 10.0 4.3 0.42 9.3 3.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain SUV3_C PF12513.3 CDI80375.1 - 1.5e-10 40.3 0.0 3.6e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 CDI80375.1 - 2.3e-06 27.3 0.0 1.1e-05 25.1 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain PNTB PF02233.11 CDI80375.1 - 1.2 7.8 3.3 2.1 7.0 2.3 1.3 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit Arena_RNA_pol PF06317.6 CDI80375.1 - 1.4 5.3 0.3 2 4.8 0.2 1.1 1 0 0 1 1 1 0 Arenavirus RNA polymerase FAD_binding_3 PF01494.14 CDI80376.1 - 1.7e-39 135.9 1.7 3.5e-18 65.7 0.0 4.6 5 0 0 5 5 5 3 FAD binding domain NAD_binding_8 PF13450.1 CDI80376.1 - 0.0023 17.8 0.0 0.0062 16.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CDI80376.1 - 0.0033 16.3 0.0 0.0066 15.3 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CDI80376.1 - 0.015 14.3 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 CDI80376.1 - 0.025 14.4 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDI80376.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI80376.1 - 0.13 12.6 0.0 0.54 10.7 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_L12 PF00542.14 CDI80377.1 - 2.2e-21 75.6 1.5 3.8e-21 74.8 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain IBN_N PF03810.14 CDI80379.1 - 1e-05 25.3 0.6 2.7e-05 23.9 0.1 2.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain HTH_1 PF00126.22 CDI80380.1 - 0.017 14.8 0.5 0.047 13.4 0.4 1.8 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HSP90 PF00183.13 CDI80382.1 - 5.3e-20 71.3 0.8 6.3e-20 71.0 0.5 1.0 1 0 0 1 1 1 1 Hsp90 protein Sugar-bind PF04198.8 CDI80383.1 - 0.032 13.1 0.0 0.043 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative sugar-binding domain Zip PF02535.17 CDI80384.1 - 0.029 13.3 7.8 0.19 10.7 0.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Pex14_N PF04695.8 CDI80384.1 - 0.086 12.8 41.6 0.024 14.6 7.8 3.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PH_4 PF15404.1 CDI80384.1 - 0.33 10.4 16.0 0.078 12.5 2.9 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain TT_ORF1 PF02956.9 CDI80384.1 - 0.59 8.5 15.1 0.048 12.1 2.8 2.0 2 0 0 2 2 2 0 TT viral orf 1 GvpL_GvpF PF06386.6 CDI80384.1 - 0.97 8.9 12.5 1.5 8.3 8.6 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Suf PF05843.9 CDI80384.1 - 1.2 8.7 20.6 0.27 10.9 7.3 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Dala_Dala_lig_N PF01820.16 CDI80384.1 - 1.6 9.0 10.9 0.47 10.7 3.2 2.3 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus GBP_C PF02841.9 CDI80384.1 - 1.9 7.6 22.6 3.4 6.7 15.7 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF2052 PF09747.4 CDI80384.1 - 3.7 7.4 26.1 4.5 7.1 11.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.10 CDI80384.1 - 6.4 5.2 22.7 2.6 6.5 5.5 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF3595 PF12166.3 CDI80387.1 - 0.00011 21.1 0.0 0.031 13.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3595) PIRT PF15099.1 CDI80387.1 - 0.5 9.5 3.4 0.96 8.6 0.0 2.3 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family DUF1218 PF06749.7 CDI80387.1 - 2.5 8.6 10.0 0.7 10.3 1.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) AlaDh_PNT_N PF05222.10 CDI80388.1 - 2.8e-23 82.4 0.1 8.5e-23 80.8 0.0 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 CDI80388.1 - 2.8e-21 75.7 0.1 5.7e-21 74.8 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.14 CDI80388.1 - 3.5e-07 29.5 0.1 1.3e-06 27.6 0.1 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CDI80388.1 - 1.7e-05 24.9 0.3 6.1e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 CDI80388.1 - 8.7e-05 22.2 0.0 0.00024 20.8 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.9 CDI80388.1 - 0.0002 19.9 0.0 0.0002 19.9 0.0 2.2 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.1 CDI80388.1 - 0.00028 21.1 0.0 0.00088 19.4 0.0 1.8 2 0 0 2 2 1 1 Putative NAD(P)-binding FAD_binding_3 PF01494.14 CDI80388.1 - 0.00067 18.8 0.1 0.0044 16.1 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 CDI80388.1 - 0.001 18.9 0.0 0.0024 17.7 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MTS PF05175.9 CDI80388.1 - 0.0012 18.2 0.1 0.0029 17.0 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Pyr_redox PF00070.22 CDI80388.1 - 0.0016 18.7 0.1 0.012 16.0 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Saccharop_dh PF03435.13 CDI80388.1 - 0.0023 16.9 0.3 0.01 14.8 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NAD_binding_2 PF03446.10 CDI80388.1 - 0.0043 16.9 0.3 0.29 10.9 0.0 2.5 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.13 CDI80388.1 - 0.0053 16.7 0.1 0.049 13.6 0.0 2.2 2 0 0 2 2 2 1 TrkA-N domain FAD_binding_2 PF00890.19 CDI80388.1 - 0.0084 15.0 0.0 0.013 14.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CDI80388.1 - 0.011 14.7 1.7 0.011 14.7 1.2 2.3 3 0 0 3 3 3 0 FAD dependent oxidoreductase DAO PF01266.19 CDI80388.1 - 0.018 13.9 0.0 0.15 10.9 0.0 2.3 3 0 0 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.12 CDI80388.1 - 0.028 13.5 0.1 0.05 12.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family UDPG_MGDP_dh_N PF03721.9 CDI80388.1 - 0.03 13.7 0.1 0.16 11.3 0.0 2.3 2 1 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.1 CDI80388.1 - 0.032 14.2 0.0 0.083 12.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Methyltransf_18 PF12847.2 CDI80388.1 - 0.06 13.9 0.0 0.2 12.2 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain ThiF PF00899.16 CDI80388.1 - 0.069 12.9 0.4 5.7 6.7 0.2 2.4 1 1 1 2 2 2 0 ThiF family XdhC_C PF13478.1 CDI80388.1 - 0.073 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain NAD_binding_10 PF13460.1 CDI80388.1 - 0.087 12.8 0.0 0.32 10.9 0.0 1.9 2 0 0 2 2 2 0 NADH(P)-binding CPSase_L_chain PF00289.17 CDI80388.1 - 0.14 12.2 1.0 0.84 9.7 0.1 2.7 3 1 0 3 3 3 0 Carbamoyl-phosphate synthase L chain, N-terminal domain FliD_N PF02465.13 CDI80388.1 - 1 9.7 11.5 3.9 7.8 1.1 3.0 3 0 0 3 3 2 0 Flagellar hook-associated protein 2 N-terminus MFS_1 PF07690.11 CDI80389.1 - 3.2e-17 62.2 38.3 5e-09 35.3 9.1 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 CDI80389.1 - 5.6e-06 25.1 1.9 5.6e-06 25.1 1.3 2.7 2 1 1 3 3 3 2 Vacuole effluxer Atg22 like MFS_2 PF13347.1 CDI80389.1 - 7.7e-06 24.5 3.5 7.7e-06 24.5 2.4 3.1 3 2 1 4 4 4 1 MFS/sugar transport protein SR-25 PF10500.4 CDI80389.1 - 1.9 7.9 10.4 5.1 6.4 7.2 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.20 CDI80390.1 - 2e-81 273.0 0.0 2.7e-81 272.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80390.1 - 1.7e-44 151.8 0.0 3.5e-43 147.5 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase EF-hand_1 PF00036.27 CDI80390.1 - 7.1e-29 96.8 8.8 2.2e-07 29.6 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDI80390.1 - 1.3e-24 86.1 5.3 5.2e-12 45.7 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI80390.1 - 3.9e-23 79.2 3.0 2.6e-05 23.7 0.0 5.4 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 CDI80390.1 - 1.8e-21 74.4 7.0 3.5e-06 26.0 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 CDI80390.1 - 3.1e-16 58.7 10.5 0.0015 18.1 0.0 4.6 2 1 2 4 4 4 4 EF-hand domain pair Kinase-like PF14531.1 CDI80390.1 - 3.2e-08 32.8 0.0 8.2e-08 31.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like SPARC_Ca_bdg PF10591.4 CDI80390.1 - 7.2e-07 29.2 1.0 0.035 14.1 0.3 2.6 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 CDI80390.1 - 6.6e-06 25.8 5.9 0.00051 19.7 0.7 3.7 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand APH PF01636.18 CDI80390.1 - 0.0033 17.1 0.0 0.027 14.1 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family EF-hand_10 PF14788.1 CDI80390.1 - 0.0081 15.7 3.5 3.6 7.3 0.0 3.8 3 1 1 4 4 4 2 EF hand Kdo PF06293.9 CDI80390.1 - 0.033 13.2 0.0 0.062 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Elf1 PF05129.8 CDI80391.1 - 3.7e-26 90.6 0.1 8.7e-26 89.4 0.1 1.7 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.1 CDI80391.1 - 0.044 14.0 0.4 0.14 12.4 0.3 1.9 1 0 0 1 1 1 0 Restriction alleviation protein Lar Cys_rich_CPXG PF14255.1 CDI80391.1 - 0.12 12.2 0.1 0.3 10.9 0.1 1.7 1 0 0 1 1 1 0 Cysteine-rich CPXCG SR-25 PF10500.4 CDI80391.1 - 0.19 11.1 25.0 0.016 14.7 14.1 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CDC27 PF09507.5 CDI80391.1 - 0.36 9.9 23.2 0.51 9.4 16.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 NTP_transferase PF00483.18 CDI80392.1 - 1.5e-32 112.8 1.8 2.3e-17 63.1 0.1 2.6 1 1 0 2 2 2 2 Nucleotidyl transferase Hexapep PF00132.19 CDI80392.1 - 1.5e-06 27.4 0.7 1.5e-06 27.4 0.5 1.8 2 0 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 CDI80392.1 - 3.2e-05 23.4 1.6 3.2e-05 23.4 1.1 2.0 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase SprA-related PF12118.3 CDI80392.1 - 0.0011 18.4 10.9 0.0011 18.4 7.6 6.5 7 0 0 7 7 7 1 SprA-related family AAA_11 PF13086.1 CDI80392.1 - 0.55 9.7 24.0 5.1 6.5 1.0 3.6 3 0 0 3 3 3 0 AAA domain zf-DHHC PF01529.15 CDI80392.1 - 6.4 6.1 12.1 0.37 10.1 0.1 3.3 3 0 0 3 3 3 0 DHHC palmitoyltransferase Suf PF05843.9 CDI80392.1 - 9.8 5.8 43.5 2 8.0 0.3 3.9 4 0 0 4 4 4 0 Suppressor of forked protein (Suf) DUF3682 PF12446.3 CDI80394.1 - 0.057 13.7 12.2 0.1 12.8 8.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Med15 PF09606.5 CDI80394.1 - 0.17 10.0 31.3 0.2 9.8 21.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI80394.1 - 1.3 8.7 10.4 1.6 8.4 7.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4557 PF15101.1 CDI80394.1 - 1.4 8.6 11.9 1.7 8.4 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Pex14_N PF04695.8 CDI80394.1 - 5.9 6.9 13.0 8.3 6.4 9.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Prenyltransf PF01255.14 CDI80395.1 - 1e-34 119.6 0.0 1.5e-33 115.8 0.0 2.0 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Spt20 PF12090.3 CDI80395.1 - 0.0011 18.3 3.6 0.083 12.2 0.1 2.1 2 0 0 2 2 2 2 Spt20 family SpaB_C PF14028.1 CDI80395.1 - 0.04 13.4 4.8 0.056 12.9 3.3 1.3 1 0 0 1 1 1 0 SpaB C-terminal domain Peptidase_S21 PF00716.12 CDI80395.1 - 0.15 11.3 7.7 0.28 10.4 5.3 1.3 1 0 0 1 1 1 0 Assemblin (Peptidase family S21) RAB3GAP2_N PF14655.1 CDI80395.1 - 0.16 10.9 6.9 1.4 7.8 0.7 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ras_bdg_2 PF14847.1 CDI80395.1 - 0.16 11.8 0.2 0.16 11.8 0.1 1.8 2 0 0 2 2 2 0 Ras-binding domain of Byr2 FimP PF09766.4 CDI80395.1 - 2.7 6.9 18.6 0.65 9.0 5.0 2.1 2 0 0 2 2 2 0 Fms-interacting protein Ribosomal_60s PF00428.14 CDI80395.1 - 2.9 8.3 19.7 8.3 6.8 8.4 2.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF342 PF03961.8 CDI80396.1 - 1.4 7.2 6.5 2.2 6.5 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APC_CDC26 PF10471.4 CDI80397.1 - 0.011 16.4 3.7 0.011 16.4 2.5 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Slu7 PF11708.3 CDI80397.1 - 0.17 11.6 5.5 0.21 11.2 3.8 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Pex14_N PF04695.8 CDI80397.1 - 0.84 9.6 6.7 1.2 9.1 4.6 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1631 PF07793.6 CDI80397.1 - 8.3 4.4 10.7 8.5 4.3 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) DUF1049 PF06305.6 CDI80398.1 - 0.0015 17.9 0.4 0.0015 17.9 0.3 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1049) CcmH PF03918.9 CDI80398.1 - 0.018 14.0 0.2 0.018 14.0 0.1 3.3 3 0 0 3 3 3 0 Cytochrome C biogenesis protein DUF1003 PF06210.6 CDI80398.1 - 0.019 14.9 4.7 0.025 14.5 2.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1003) TMEM154 PF15102.1 CDI80398.1 - 0.034 13.8 0.4 0.034 13.8 0.3 2.4 2 1 0 2 2 2 0 TMEM154 protein family UPF0542 PF15086.1 CDI80398.1 - 0.042 13.5 0.3 0.042 13.5 0.2 2.5 3 1 0 3 3 3 0 Uncharacterised protein family UPF0542 V_ATPase_I PF01496.14 CDI80398.1 - 0.16 9.8 0.2 0.23 9.2 0.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PEX11 PF05648.9 CDI80398.1 - 0.22 10.7 3.2 0.25 10.5 0.6 2.2 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) EphA2_TM PF14575.1 CDI80398.1 - 0.3 11.5 0.2 0.3 11.5 0.1 2.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Neur_chan_memb PF02932.11 CDI80398.1 - 1.1 9.0 7.0 0.13 12.1 0.8 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ctr PF04145.10 CDI80398.1 - 1.8 8.6 15.9 2.5 8.1 5.9 3.1 2 1 0 2 2 2 0 Ctr copper transporter family BatA PF07584.6 CDI80398.1 - 2.8 8.2 9.4 2.3 8.4 3.0 2.6 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Prenyltrans PF00432.16 CDI80400.1 - 1.1e-16 60.0 30.3 9.4e-10 37.8 0.7 5.5 6 0 0 6 6 6 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CDI80400.1 - 2.8e-11 43.8 1.6 7.8e-09 35.9 0.1 3.9 3 1 1 4 4 4 2 Prenyltransferase-like CCDC14 PF15254.1 CDI80400.1 - 0.00066 18.2 7.3 0.00083 17.8 5.1 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 HemX PF04375.9 CDI80400.1 - 0.0016 17.1 10.4 0.0024 16.5 7.2 1.2 1 0 0 1 1 1 1 HemX Med15 PF09606.5 CDI80400.1 - 0.0059 14.8 14.5 0.0079 14.4 10.1 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DivIC PF04977.10 CDI80400.1 - 0.011 15.1 8.2 0.02 14.3 5.7 1.4 1 0 0 1 1 1 0 Septum formation initiator TFIIA PF03153.8 CDI80400.1 - 0.021 14.7 10.1 0.029 14.2 7.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FimP PF09766.4 CDI80400.1 - 0.028 13.4 9.4 0.041 12.9 6.5 1.2 1 0 0 1 1 1 0 Fms-interacting protein Suf PF05843.9 CDI80400.1 - 0.029 14.1 4.4 0.035 13.8 3.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hus1 PF04005.7 CDI80400.1 - 0.049 12.5 1.0 0.077 11.9 0.7 1.2 1 0 0 1 1 1 0 Hus1-like protein FHIPEP PF00771.15 CDI80400.1 - 0.05 11.9 0.9 0.069 11.4 0.6 1.1 1 0 0 1 1 1 0 FHIPEP family FMN_dh PF01070.13 CDI80400.1 - 0.065 12.0 0.3 0.1 11.4 0.2 1.4 1 0 0 1 1 1 0 FMN-dependent dehydrogenase RED_N PF07808.8 CDI80400.1 - 0.15 11.2 7.6 0.22 10.7 5.2 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region PAT1 PF09770.4 CDI80400.1 - 0.49 8.5 16.6 0.62 8.2 11.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3270 PF11674.3 CDI80400.1 - 0.66 10.0 5.6 1.2 9.1 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) Serinc PF03348.10 CDI80400.1 - 0.94 8.1 3.1 0.56 8.8 0.9 1.5 2 0 0 2 2 2 0 Serine incorporator (Serinc) FAM176 PF14851.1 CDI80400.1 - 1 9.0 4.3 1.7 8.3 3.0 1.2 1 0 0 1 1 1 0 FAM176 family Activator_LAG-3 PF11498.3 CDI80400.1 - 3.9 6.0 25.1 6.3 5.4 17.4 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 UPF0560 PF10577.4 CDI80400.1 - 6.1 4.9 10.5 8.3 4.5 7.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4175 PF13779.1 CDI80400.1 - 9.2 3.8 22.1 13 3.2 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Pam16 PF03656.8 CDI80401.1 - 0.0063 16.3 1.7 0.0063 16.3 1.2 2.8 2 1 2 4 4 4 1 Pam16 Dehydrin PF00257.14 CDI80401.1 - 0.12 12.6 0.9 6.1 7.1 0.1 2.1 2 0 0 2 2 2 0 Dehydrin RAP1 PF07218.6 CDI80403.1 - 2 6.4 24.3 2.6 6.0 16.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SRCR PF00530.13 CDI80404.1 - 3.7e-23 81.7 13.3 6e-18 65.0 2.8 3.1 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain LCCL PF03815.14 CDI80404.1 - 1.9e-18 66.2 0.1 1.7e-17 63.1 0.0 2.4 2 0 0 2 2 2 1 LCCL domain PLAT PF01477.18 CDI80404.1 - 5.3e-10 39.6 0.0 3e-08 33.9 0.0 2.3 1 1 1 2 2 2 1 PLAT/LH2 domain SRCR_2 PF15494.1 CDI80404.1 - 4.6e-05 23.5 0.6 0.00011 22.3 0.4 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF3875 PF12991.2 CDI80404.1 - 0.023 14.3 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3875) MCE PF02470.15 CDI80404.1 - 0.095 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 mce related protein WD40 PF00400.27 CDI80409.1 - 2.2e-20 71.7 8.1 5.3e-05 22.9 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 CDI80409.1 - 2.7e-05 24.2 0.0 7.9e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit Plasmodium_Vir PF05795.6 CDI80412.1 - 2.3 7.3 25.5 10 5.1 12.3 3.3 2 1 1 3 3 3 0 Plasmodium vivax Vir protein MutS_V PF00488.16 CDI80413.1 - 1.9e-48 164.9 0.1 2.3e-48 164.6 0.1 1.2 1 0 0 1 1 1 1 MutS domain V AAA_29 PF13555.1 CDI80413.1 - 0.013 15.0 0.2 0.023 14.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 CDI80413.1 - 0.034 14.0 0.1 0.2 11.5 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CDI80413.1 - 0.14 12.5 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.4 CDI80413.1 - 0.17 10.7 0.1 0.24 10.2 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MutS_III PF05192.13 CDI80414.1 - 9.4e-33 113.7 1.7 5.7e-32 111.1 1.2 2.3 1 1 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 CDI80414.1 - 3.4e-09 36.7 0.2 7.5e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_22 PF13401.1 CDI80414.1 - 0.013 15.6 0.2 0.27 11.3 0.0 2.9 2 1 1 3 3 3 0 AAA domain Spore_coat_CotO PF14153.1 CDI80415.1 - 0.0066 15.9 14.4 0.0066 15.9 10.0 3.1 3 0 0 3 3 3 1 Spore coat protein CotO RRM_6 PF14259.1 CDI80415.1 - 0.081 12.9 0.0 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Mem_trans PF03547.13 CDI80415.1 - 0.97 7.6 2.2 1.8 6.7 1.5 1.5 1 0 0 1 1 1 0 Membrane transport protein PAT1 PF09770.4 CDI80415.1 - 5.1 5.2 71.4 0.075 11.2 4.6 3.1 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 Raftlin PF15250.1 CDI80415.1 - 9.2 4.6 21.0 0.021 13.3 3.9 3.0 3 0 0 3 3 3 0 Raftlin TruD PF01142.13 CDI80416.1 - 2.8e-40 138.1 7.5 1.2e-20 73.5 0.0 5.7 5 1 1 6 6 6 3 tRNA pseudouridine synthase D (TruD) HEM4 PF02602.10 CDI80417.1 - 5.4e-06 25.8 36.4 0.0043 16.3 0.3 4.8 3 2 0 3 3 3 2 Uroporphyrinogen-III synthase HemD MtN3_slv PF03083.11 CDI80418.1 - 6.3e-14 51.6 5.8 6.1e-08 32.4 0.2 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange Neur_chan_memb PF02932.11 CDI80418.1 - 0.035 14.0 5.0 1.2 8.9 0.4 2.5 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Tfb4 PF03850.9 CDI80424.1 - 1.1e-14 54.4 1.2 1.4e-13 50.7 0.0 2.6 2 1 0 2 2 2 1 Transcription factor Tfb4 Activator_LAG-3 PF11498.3 CDI80424.1 - 9.5 4.8 26.6 24 3.5 18.5 1.6 1 0 0 1 1 1 0 Transcriptional activator LAG-3 zf-DHHC PF01529.15 CDI80425.1 - 7.8e-20 70.9 23.0 7.8e-20 70.9 15.9 3.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase APC_CDC26 PF10471.4 CDI80426.1 - 0.17 12.6 5.7 0.32 11.7 4.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 SoxE PF06525.6 CDI80426.1 - 0.28 10.4 3.1 0.25 10.5 1.0 1.7 1 1 1 2 2 2 0 Sulfocyanin (SoxE) DNA_pol_viral_N PF00242.12 CDI80426.1 - 0.38 9.7 6.7 0.46 9.4 4.6 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Macoilin PF09726.4 CDI80426.1 - 0.62 8.2 5.3 0.63 8.2 3.7 1.0 1 0 0 1 1 1 0 Transmembrane protein PAP1 PF08601.5 CDI80426.1 - 0.64 9.6 8.9 0.75 9.4 6.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Sporozoite_P67 PF05642.6 CDI80426.1 - 0.95 7.2 5.3 1.1 7.0 3.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SR-25 PF10500.4 CDI80426.1 - 1 8.7 20.3 1.4 8.2 14.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3617 PF12276.3 CDI80426.1 - 2.9 7.3 8.7 6 6.3 2.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3617) Helicase_C_2 PF13307.1 CDI80428.1 - 2.7e-37 128.2 5.8 2.7e-37 128.2 4.0 3.4 2 1 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.10 CDI80428.1 - 7.3e-17 61.3 1.4 2.3e-16 59.7 0.0 2.5 2 0 0 2 2 2 1 DEAD_2 Helicase_C PF00271.26 CDI80429.1 - 0.0078 16.0 0.0 0.0078 16.0 0.0 4.2 5 0 0 5 5 5 2 Helicase conserved C-terminal domain U1snRNP70_N PF12220.3 CDI80429.1 - 4.3 7.7 52.2 2.2 8.6 3.4 4.8 4 0 0 4 4 4 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MORN PF02493.15 CDI80430.1 - 1.7e-93 301.1 101.0 1.1e-09 37.4 1.6 14.4 14 0 0 14 14 14 14 MORN repeat CPSase_sm_chain PF00988.17 CDI80430.1 - 0.43 10.0 4.0 45 3.5 0.0 4.3 4 0 0 4 4 4 0 Carbamoyl-phosphate synthase small chain, CPSase domain SH3_9 PF14604.1 CDI80430.1 - 2.1 8.0 9.8 39 3.9 0.1 5.0 3 1 1 4 4 4 0 Variant SH3 domain Ureidogly_hydro PF04115.7 CDI80432.1 - 0.041 13.2 0.0 0.1 11.9 0.0 1.6 2 0 0 2 2 2 0 Ureidoglycolate hydrolase Serpin PF00079.15 CDI80433.1 - 3.3e-78 263.3 0.2 3.9e-78 263.1 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PRMT5 PF05185.11 CDI80434.1 - 2.8e-05 23.2 0.0 4.2e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_3 PF01596.12 CDI80434.1 - 0.0079 15.2 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PrmA PF06325.8 CDI80434.1 - 0.033 13.3 0.0 0.23 10.5 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 CDI80434.1 - 0.1 13.2 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_S8 PF00082.17 CDI80435.1 - 1.7e-29 102.8 0.0 5.2e-29 101.2 0.0 1.7 1 1 0 1 1 1 1 Subtilase family AP2 PF00847.15 CDI80436.1 - 1.1e-05 25.5 1.2 4.6e-05 23.4 0.7 2.2 2 0 0 2 2 2 1 AP2 domain MS_channel PF00924.13 CDI80437.1 - 1.4e-11 44.0 1.6 2.4e-11 43.3 1.1 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_8 PF13833.1 CDI80437.1 - 0.017 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 EF-hand domain pair DUF2513 PF10711.4 CDI80438.1 - 0.037 14.1 0.0 0.54 10.3 0.0 2.3 2 0 0 2 2 2 0 Hypothetical protein (DUF2513) DUF4423 PF14394.1 CDI80438.1 - 0.038 13.5 0.1 0.058 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) tRNA_anti-codon PF01336.20 CDI80438.1 - 0.069 13.0 0.0 0.31 10.9 0.0 2.1 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain Trans_reg_C PF00486.23 CDI80438.1 - 0.13 12.2 0.1 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal UDPGP PF01704.13 CDI80439.1 - 0.00016 20.2 0.3 0.016 13.7 0.1 2.4 2 1 0 2 2 2 2 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 CDI80439.1 - 0.0054 16.8 3.9 0.044 13.8 0.0 3.2 3 0 0 3 3 3 1 MobA-like NTP transferase domain FTR PF01913.13 CDI80439.1 - 0.11 12.2 1.8 0.24 11.1 1.3 1.6 1 0 0 1 1 1 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase Med15 PF09606.5 CDI80439.1 - 0.3 9.2 34.4 0.22 9.6 6.3 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI80439.1 - 4.5 6.9 16.6 4.9 6.7 6.7 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) RRM_1 PF00076.17 CDI80440.1 - 1e-05 25.0 0.0 2.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80440.1 - 0.00019 21.3 0.0 0.00042 20.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF883 PF05957.8 CDI80440.1 - 0.32 11.4 9.9 0.49 10.8 6.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF1744 PF08490.7 CDI80442.1 - 4.5e-13 48.5 8.4 2.9e-12 45.9 0.0 3.8 4 1 0 4 4 4 2 Domain of unknown function (DUF1744) Sigma70_ner PF04546.8 CDI80442.1 - 1.1 8.8 32.8 2.2 7.8 0.6 4.1 4 0 0 4 4 4 0 Sigma-70, non-essential region RRM_1 PF00076.17 CDI80444.1 - 3.1e-06 26.7 0.0 0.0052 16.3 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80444.1 - 4e-06 26.5 0.0 0.021 14.6 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80444.1 - 0.0056 16.6 0.0 0.17 11.8 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CAP_N PF01213.14 CDI80444.1 - 0.071 12.3 0.5 0.11 11.7 0.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF4175 PF13779.1 CDI80444.1 - 0.12 10.0 1.8 0.17 9.5 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CAP_C PF08603.6 CDI80445.1 - 3.4e-52 175.9 0.6 3.8e-52 175.8 0.4 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.7 CDI80445.1 - 6e-06 25.6 0.5 8.8e-06 25.1 0.3 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Glucan_synthase PF02364.10 CDI80449.1 - 1.4e-70 238.2 14.4 3.4e-24 84.8 2.1 4.6 3 2 1 4 4 4 4 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 CDI80449.1 - 1.8e-18 66.5 2.0 4.7e-18 65.1 1.4 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 MORN PF02493.15 CDI80453.1 - 1.7e-35 118.6 39.2 5.4e-06 25.8 3.0 8.4 8 1 1 9 9 9 7 MORN repeat SM-ATX PF14438.1 CDI80453.1 - 0.21 11.5 2.3 7.9 6.4 0.0 3.9 4 1 1 5 5 5 0 Ataxin 2 SM domain Ribosomal_L7Ae PF01248.21 CDI80454.1 - 1.1e-13 50.4 0.1 1.6e-13 49.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.1 CDI80454.1 - 0.001 18.9 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF2959 PF11172.3 CDI80454.1 - 0.036 13.8 0.2 0.045 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) APP_Cu_bd PF12924.2 CDI80454.1 - 0.056 13.9 1.2 0.15 12.5 0.0 2.1 3 0 0 3 3 3 0 Copper-binding of amyloid precursor, CuBD DivIC PF04977.10 CDI80454.1 - 0.12 11.8 3.7 0.21 11.0 2.6 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF2489 PF10675.4 CDI80454.1 - 0.32 10.6 6.5 0.51 10.0 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) Med3 PF11593.3 CDI80454.1 - 2.5 7.2 10.2 3.2 6.9 7.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Activator_LAG-3 PF11498.3 CDI80454.1 - 3.2 6.3 16.9 4.1 6.0 11.7 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Ndc1_Nup PF09531.5 CDI80455.1 - 0.00079 17.9 3.9 0.00079 17.9 2.7 5.1 3 2 1 6 6 6 2 Nucleoporin protein Ndc1-Nup Ribosomal_S4 PF00163.14 CDI80456.1 - 9.6e-10 38.7 0.4 1.3e-09 38.3 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 CDI80456.1 - 5.8e-06 25.6 0.0 1.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain Surface_antigen PF11054.3 CDI80458.1 - 4.4e-32 111.4 17.7 1.8e-08 34.1 0.1 7.3 1 1 4 5 5 5 5 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI80459.1 - 8e-34 117.1 19.4 1.8e-14 53.7 0.9 5.2 1 1 2 4 4 4 4 Sporozoite TA4 surface antigen T2SF PF00482.18 CDI80460.1 - 0.1 12.5 1.3 2.6 7.9 0.0 3.1 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F Surface_antigen PF11054.3 CDI80461.1 - 3.6e-09 36.3 0.7 1.2e-07 31.3 0.1 2.0 1 1 1 2 2 2 2 Sporozoite TA4 surface antigen Surface_antigen PF11054.3 CDI80462.1 - 7.1e-13 48.5 8.1 6e-12 45.4 3.0 2.6 1 1 1 2 2 2 2 Sporozoite TA4 surface antigen SPT2 PF08243.6 CDI80463.1 - 3.7e-07 30.4 11.4 3.7e-07 30.4 7.9 5.0 4 1 0 4 4 4 1 SPT2 chromatin protein Ribosomal_60s PF00428.14 CDI80463.1 - 7.6 7.0 20.9 7.2 7.0 0.7 3.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein MCM PF00493.18 CDI80464.1 - 4.6e-93 311.6 0.3 7.4e-82 274.7 0.0 3.3 2 1 1 3 3 3 3 MCM2/3/5 family Mg_chelatase PF01078.16 CDI80464.1 - 2.7e-07 29.9 0.3 1.4e-06 27.6 0.0 2.3 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.1 CDI80464.1 - 0.00023 21.6 0.1 0.00083 19.8 0.1 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Sigma54_activat PF00158.21 CDI80464.1 - 0.0055 16.1 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Macoilin PF09726.4 CDI80464.1 - 0.23 9.7 39.2 0.037 12.3 20.7 2.7 2 0 0 2 2 2 0 Transmembrane protein Kelch_1 PF01344.20 CDI80466.1 - 2.3e-15 55.8 0.2 7.3e-10 38.2 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 CDI80466.1 - 3.6e-10 39.5 2.2 7.2e-07 29.1 0.0 4.0 3 1 1 4 4 4 1 Kelch motif Kelch_2 PF07646.10 CDI80466.1 - 4.1e-06 26.3 0.1 3.3e-05 23.4 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 CDI80466.1 - 1.9e-05 24.3 0.8 0.0007 19.3 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI80466.1 - 0.00037 20.3 0.0 0.9 9.5 0.0 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 CDI80466.1 - 0.006 16.7 1.8 0.075 13.2 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain FimP PF09766.4 CDI80466.1 - 0.034 13.2 9.2 0.049 12.6 6.4 1.1 1 0 0 1 1 1 0 Fms-interacting protein Suf PF05843.9 CDI80466.1 - 0.78 9.4 12.9 0.044 13.5 4.7 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Serinc PF03348.10 CDI80466.1 - 8.7 4.9 4.8 14 4.2 3.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) AUX_IAA PF02309.11 CDI80466.1 - 9.6 5.8 8.3 2.1 8.0 2.6 2.2 2 0 0 2 2 2 0 AUX/IAA family Pkinase PF00069.20 CDI80467.1 - 7.3e-24 84.3 0.6 7.3e-24 84.3 0.4 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80467.1 - 2.8e-11 42.9 0.9 8.4e-11 41.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CDI80467.1 - 0.16 10.7 0.1 0.3 9.8 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 CDI80467.1 - 0.18 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Imm28 PF15574.1 CDI80468.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 28 MSP1_C PF07462.6 CDI80469.1 - 0.0052 15.2 7.6 0.0075 14.7 5.3 1.2 1 0 0 1 1 1 1 Merozoite surface protein 1 (MSP1) C-terminus 5-FTHF_cyc-lig PF01812.15 CDI80471.1 - 2.2e-16 60.1 6.7 1.6e-12 47.5 4.5 2.4 2 0 0 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family Ycf1 PF05758.7 CDI80471.1 - 6.3e-05 20.9 0.5 6.3e-05 20.9 0.3 1.1 1 0 0 1 1 1 1 Ycf1 YjgP_YjgQ PF03739.9 CDI80471.1 - 0.0068 15.1 1.8 0.011 14.5 1.2 1.4 1 0 0 1 1 1 1 Predicted permease YjgP/YjgQ family DUF3675 PF12428.3 CDI80471.1 - 0.019 15.2 3.1 0.019 15.2 2.1 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF3675) PBP1_TM PF14812.1 CDI80471.1 - 0.036 14.3 1.0 0.07 13.4 0.7 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CK_II_beta PF01214.13 CDI80471.1 - 0.047 13.2 5.9 0.086 12.3 4.1 1.4 1 0 0 1 1 1 0 Casein kinase II regulatory subunit LMBR1 PF04791.11 CDI80471.1 - 0.064 11.8 0.7 0.067 11.7 0.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3899 PF13038.1 CDI80471.1 - 0.082 13.0 1.8 5.9 7.1 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3899) Hid1 PF12722.2 CDI80471.1 - 0.13 9.9 11.0 0.17 9.5 7.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HlyD_2 PF12700.2 CDI80471.1 - 0.13 11.3 9.0 0.22 10.6 6.2 1.3 1 0 0 1 1 1 0 HlyD family secretion protein HCO3_cotransp PF00955.16 CDI80471.1 - 0.2 10.3 6.5 0.29 9.7 4.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family APG6 PF04111.7 CDI80471.1 - 0.28 10.1 22.2 0.6 9.0 15.4 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 AIF_C PF14721.1 CDI80471.1 - 0.29 11.3 9.9 1.3 9.2 5.6 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Dynamin_N PF00350.18 CDI80471.1 - 0.5 10.1 7.9 0.09 12.5 1.9 2.1 2 0 0 2 2 2 0 Dynamin family DUF4220 PF13968.1 CDI80471.1 - 0.9 8.5 6.7 1.7 7.6 4.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Cellulose_synt PF03552.9 CDI80471.1 - 1.1 7.4 4.3 1.4 7.0 2.9 1.1 1 0 0 1 1 1 0 Cellulose synthase Peptidase_U57 PF05582.7 CDI80471.1 - 1.9 7.3 13.1 3.5 6.5 9.1 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Presenilin PF01080.12 CDI80471.1 - 2 7.1 7.6 0.3 9.8 2.6 1.5 2 0 0 2 2 2 0 Presenilin Paramyxo_ncap PF00973.14 CDI80471.1 - 4.5 5.8 9.4 6.5 5.3 6.5 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF912 PF06024.7 CDI80471.1 - 4.5 7.3 18.4 21 5.2 10.3 2.7 2 1 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PRP1_N PF06424.7 CDI80471.1 - 6.1 7.1 17.0 1.6 9.0 9.5 1.7 2 0 0 2 2 1 0 PRP1 splicing factor, N-terminal FAM60A PF15396.1 CDI80471.1 - 6.7 6.3 14.3 3.6 7.2 8.5 1.5 2 0 0 2 2 1 0 Protein Family FAM60A DUF3533 PF12051.3 CDI80471.1 - 7.5 5.1 9.2 3.3 6.3 3.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3533) Pkinase PF00069.20 CDI80472.1 - 1.4e-25 89.9 0.0 2.4e-22 79.3 0.0 4.1 2 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80472.1 - 3.8e-12 45.8 0.0 8e-11 41.4 0.0 2.9 3 1 0 3 3 3 1 Protein tyrosine kinase T2SF PF00482.18 CDI80472.1 - 0.0082 16.0 0.3 0.0082 16.0 0.2 2.8 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F PAP_assoc PF03828.14 CDI80473.1 - 0.0012 18.7 0.1 0.0037 17.1 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase SR-25 PF10500.4 CDI80473.1 - 0.0023 17.4 16.1 0.0023 17.4 11.1 11.0 7 2 3 10 10 10 3 Nuclear RNA-splicing-associated protein NTP_transf_2 PF01909.18 CDI80473.1 - 0.13 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain Ribosomal_60s PF00428.14 CDI80474.1 - 0.038 14.3 2.4 0.038 14.3 1.7 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF2076 PF09849.4 CDI80474.1 - 0.73 9.8 31.1 0.17 11.9 11.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) WEMBL PF05701.6 CDI80476.1 - 9 4.6 18.2 12 4.1 12.6 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Pkinase PF00069.20 CDI80477.1 - 2.7e-36 125.0 0.0 7.4e-30 103.9 0.0 3.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80477.1 - 6.7e-10 38.4 0.0 0.0001 21.5 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase AMP-binding PF00501.23 CDI80478.1 - 0.00049 18.6 6.3 0.13 10.6 2.7 2.8 2 2 0 2 2 2 2 AMP-binding enzyme Med3 PF11593.3 CDI80479.1 - 0.0077 15.5 1.1 0.0077 15.5 0.7 2.1 1 1 1 2 2 2 1 Mediator complex subunit 3 fungal RskA PF10099.4 CDI80479.1 - 3.5 7.3 9.0 0.8 9.4 1.1 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Nop53 PF07767.6 CDI80479.1 - 7.1 5.5 29.9 0.013 14.4 10.5 2.0 1 1 1 2 2 2 0 Nop53 (60S ribosomal biogenesis) ZYG-11_interact PF05884.7 CDI80482.1 - 0.027 13.5 1.0 0.041 12.9 0.7 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 HABP4_PAI-RBP1 PF04774.10 CDI80482.1 - 8.6 6.9 16.7 8.6 6.9 3.3 2.7 2 1 1 3 3 3 0 Hyaluronan / mRNA binding family Abhydrolase_6 PF12697.2 CDI80484.1 - 4.7e-31 108.4 3.0 1.1e-30 107.2 2.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI80484.1 - 4.9e-21 75.3 0.5 3.7e-20 72.4 0.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDI80484.1 - 5.9e-18 65.0 4.4 6.3e-16 58.4 3.1 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CDI80484.1 - 3.7e-09 36.3 0.0 8.5e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 CDI80484.1 - 3.7e-06 26.3 0.0 3.7e-06 26.3 0.0 3.7 2 1 3 5 5 3 1 Dienelactone hydrolase family BAAT_C PF08840.6 CDI80484.1 - 5.5e-06 26.2 9.2 0.0054 16.4 0.0 3.2 2 1 1 3 3 3 2 BAAT / Acyl-CoA thioester hydrolase C terminal Ndr PF03096.9 CDI80484.1 - 2.8e-05 22.7 0.4 0.00046 18.7 0.0 2.4 2 0 0 2 2 2 1 Ndr family PGAP1 PF07819.8 CDI80484.1 - 0.00082 19.0 0.0 0.0019 17.8 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein DUF1057 PF06342.7 CDI80484.1 - 0.0012 17.6 0.0 0.0023 16.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Esterase PF00756.15 CDI80484.1 - 0.0016 17.8 7.8 0.0016 17.8 5.4 3.3 3 1 0 3 3 2 1 Putative esterase Peptidase_S9 PF00326.16 CDI80484.1 - 0.02 14.1 2.5 0.085 12.0 0.0 2.7 3 0 0 3 3 3 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 CDI80484.1 - 0.021 13.7 0.0 0.059 12.2 0.0 1.7 1 0 0 1 1 1 0 Chlorophyllase enzyme UPF0565 PF10561.4 CDI80484.1 - 0.1 11.4 0.0 0.1 11.4 0.0 3.9 3 1 0 3 3 3 0 Uncharacterised protein family UPF0565 Chlorophyllase PF07224.6 CDI80484.1 - 0.12 11.1 0.1 0.26 10.0 0.1 1.4 1 1 0 1 1 1 0 Chlorophyllase Abhydrolase_5 PF12695.2 CDI80485.1 - 0.00018 21.3 0.1 0.0044 16.7 0.1 3.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CDI80485.1 - 0.00019 21.2 0.0 0.13 12.1 0.0 2.7 2 0 0 2 2 2 2 Putative lysophospholipase UPF0227 PF05728.7 CDI80485.1 - 0.033 13.9 0.0 0.033 13.9 0.0 3.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0227) Ycf1 PF05758.7 CDI80485.1 - 1.4 6.5 10.2 0.23 9.1 0.0 2.6 3 0 0 3 3 3 0 Ycf1 Tim54 PF11711.3 CDI80485.1 - 2 6.8 14.4 0.051 12.1 1.0 2.7 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 DUF2052 PF09747.4 CDI80485.1 - 6.7 6.6 25.3 0.1 12.5 3.3 3.4 4 0 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) HSP70 PF00012.15 CDI80486.1 - 0.00015 19.8 0.1 0.00059 17.8 0.1 1.9 1 1 0 1 1 1 1 Hsp70 protein MFS_1 PF07690.11 CDI80487.1 - 3e-08 32.7 26.8 3e-08 32.7 18.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily ERGIC_N PF13850.1 CDI80487.1 - 0.023 14.6 1.1 0.048 13.6 0.1 2.0 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PCNA_N PF00705.13 CDI80488.1 - 7.4e-23 80.4 0.7 3.4e-22 78.2 0.3 1.9 1 1 1 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 CDI80488.1 - 2.3e-07 30.7 0.0 1.8e-06 27.8 0.0 2.4 1 1 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain G3P_antiterm PF04309.7 CDI80488.1 - 0.016 14.2 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator Rad9 PF04139.8 CDI80488.1 - 0.035 13.2 0.1 0.041 12.9 0.1 1.3 1 0 0 1 1 1 0 Rad9 zf-MYND PF01753.13 CDI80489.1 - 0.25 11.2 3.2 4 7.3 0.2 2.7 2 0 0 2 2 2 0 MYND finger Med15 PF09606.5 CDI80491.1 - 0.0021 16.3 50.4 0.0021 16.3 35.0 2.5 2 1 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Aminotran_1_2 PF00155.16 CDI80492.1 - 6.2e-72 242.5 0.0 6.2e-72 242.5 0.0 3.6 2 1 2 4 4 4 1 Aminotransferase class I and II RAP1 PF07218.6 CDI80492.1 - 0.0085 14.2 4.3 0.014 13.5 3.0 1.2 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.4 CDI80492.1 - 0.094 10.9 28.4 0.14 10.4 19.7 1.3 1 0 0 1 1 1 0 Transmembrane protein CAF-1_p150 PF11600.3 CDI80492.1 - 1.3 8.3 40.4 2.7 7.3 28.0 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3449 PF11931.3 CDI80493.1 - 5.5e-08 32.5 1.0 5.5e-08 32.5 0.7 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3a60_bindingd PF12108.3 CDI80493.1 - 5.5e-08 32.1 0.1 1.8e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain Orthopox_F8 PF05886.6 CDI80493.1 - 0.12 12.2 0.6 0.37 10.6 0.4 1.8 1 0 0 1 1 1 0 Orthopoxvirus F8 protein DUF4094 PF13334.1 CDI80493.1 - 0.19 12.1 0.1 0.19 12.1 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) S-antigen PF05756.6 CDI80493.1 - 3.6 7.6 7.1 7 6.6 4.6 1.8 1 1 0 1 1 1 0 S-antigen protein PAT1 PF09770.4 CDI80497.1 - 0.83 7.8 100.8 1 7.4 69.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI80497.1 - 1.2 7.3 124.1 1.4 6.9 86.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RAP1 PF07218.6 CDI80497.1 - 1.3 6.9 24.5 1.6 6.6 17.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2868 PF11067.3 CDI80497.1 - 5 6.1 32.3 6.2 5.8 22.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) IMCp PF12314.3 CDI80498.1 - 5.4e-06 26.4 20.0 5.4e-06 26.4 13.9 2.1 2 1 0 2 2 2 1 Inner membrane complex protein MAR_sialic_bdg PF10564.4 CDI80499.1 - 5.7e-09 35.6 2.5 1e-08 34.8 1.7 1.4 1 0 0 1 1 1 1 Sialic-acid binding micronemal adhesive repeat Complex1_LYR PF05347.10 CDI80500.1 - 0.0099 15.6 0.5 0.035 13.8 0.1 2.1 2 1 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CDI80500.1 - 0.081 13.1 0.5 0.12 12.6 0.3 1.6 1 1 0 1 1 1 0 Complex1_LYR-like tRNA-synt_1b PF00579.20 CDI80501.1 - 3.6e-48 164.1 0.0 2.3e-31 109.0 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (W and Y) Pex14_N PF04695.8 CDI80501.1 - 0.098 12.7 2.2 0.17 11.9 1.6 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Macoilin PF09726.4 CDI80501.1 - 5.2 5.2 7.2 8.2 4.5 5.0 1.2 1 0 0 1 1 1 0 Transmembrane protein BAF1_ABF1 PF04684.8 CDI80502.1 - 0.00016 20.6 12.4 0.00022 20.2 8.6 1.3 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor Ycf1 PF05758.7 CDI80502.1 - 0.042 11.5 5.3 0.044 11.5 3.7 1.1 1 0 0 1 1 1 0 Ycf1 Serinc PF03348.10 CDI80502.1 - 0.045 12.4 3.9 0.062 12.0 2.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Cwf_Cwc_15 PF04889.7 CDI80502.1 - 0.096 12.3 12.7 0.13 11.9 8.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Med15 PF09606.5 CDI80502.1 - 0.12 10.5 26.3 0.11 10.6 18.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CDK2AP PF09806.4 CDI80502.1 - 0.16 12.1 10.0 0.26 11.4 6.9 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Pex14_N PF04695.8 CDI80502.1 - 0.2 11.7 9.4 0.29 11.1 6.5 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Dala_Dala_lig_N PF01820.16 CDI80502.1 - 0.21 11.9 2.6 0.79 10.0 0.8 2.1 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus DUF4175 PF13779.1 CDI80502.1 - 0.25 9.0 21.5 0.25 9.0 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Neur_chan_memb PF02932.11 CDI80502.1 - 0.64 9.8 5.7 0.82 9.5 4.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4557 PF15101.1 CDI80502.1 - 0.76 9.5 12.6 1.2 8.8 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Band_3_cyto PF07565.8 CDI80502.1 - 0.77 9.2 8.0 1.1 8.7 5.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SpaB_C PF14028.1 CDI80502.1 - 0.8 9.1 7.7 0.97 8.9 5.4 1.1 1 0 0 1 1 1 0 SpaB C-terminal domain Suf PF05843.9 CDI80502.1 - 0.96 9.1 12.9 1.3 8.6 8.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM176 PF14851.1 CDI80502.1 - 1.1 8.9 6.6 1.1 8.8 1.8 2.1 2 0 0 2 2 2 0 FAM176 family DUF2215 PF10225.4 CDI80502.1 - 1.5 8.2 3.5 2 7.7 2.5 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Hid1 PF12722.2 CDI80502.1 - 2 6.0 8.8 1.9 6.0 6.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med5 PF08689.5 CDI80502.1 - 2.1 5.9 7.5 2.4 5.7 5.2 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 Pal1 PF08316.6 CDI80502.1 - 2.3 8.6 10.6 2.9 8.3 4.8 2.1 1 1 1 2 2 2 0 Pal1 cell morphology protein E_Pc_C PF06752.7 CDI80502.1 - 2.7 7.4 18.5 3.9 6.9 12.8 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Presenilin PF01080.12 CDI80502.1 - 3.5 6.3 4.5 4.2 6.0 3.1 1.3 1 0 0 1 1 1 0 Presenilin FAM183 PF14886.1 CDI80502.1 - 3.7 8.1 14.4 0.71 10.4 7.6 1.5 2 0 0 2 2 1 0 FAM183A and FAM183B related SpoVR PF04293.8 CDI80502.1 - 4.2 5.6 9.9 6.2 5.0 5.8 1.8 2 0 0 2 2 2 0 SpoVR like protein DDRGK PF09756.4 CDI80502.1 - 4.9 6.5 14.5 1.9 7.8 7.0 2.0 2 0 0 2 2 2 0 DDRGK domain Shisa PF13908.1 CDI80502.1 - 6.5 6.8 11.4 9.5 6.3 7.9 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Cupin_2 PF07883.6 CDI80504.1 - 0.00019 20.8 0.0 0.00037 19.9 0.0 1.4 1 0 0 1 1 1 1 Cupin domain SpoVAB PF13782.1 CDI80505.1 - 0.37 10.7 2.6 0.82 9.6 0.4 2.0 2 0 0 2 2 2 0 Stage V sporulation protein AB YjgP_YjgQ PF03739.9 CDI80506.1 - 5.9 5.5 17.1 0.21 10.2 5.8 2.7 2 1 0 2 2 2 0 Predicted permease YjgP/YjgQ family Cu_amine_oxid PF01179.15 CDI80507.1 - 6.6e-71 239.1 0.3 6.6e-71 239.1 0.2 1.8 2 1 0 2 2 2 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.5 CDI80507.1 - 0.02 14.7 0.1 0.051 13.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) Med3 PF11593.3 CDI80507.1 - 0.02 14.1 6.2 0.029 13.6 4.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal IncA PF04156.9 CDI80507.1 - 4.3 6.8 12.4 6.1 6.3 8.6 1.1 1 0 0 1 1 1 0 IncA protein Raffinose_syn PF05691.7 CDI80508.1 - 0.0043 14.6 0.0 0.007 13.9 0.0 1.2 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Glt_symporter PF03616.9 CDI80508.1 - 0.078 11.4 0.0 0.078 11.4 0.0 1.7 2 0 0 2 2 2 0 Sodium/glutamate symporter Abhydro_lipase PF04083.11 CDI80508.1 - 0.29 10.5 2.3 0.48 9.8 0.0 2.6 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region DcuC PF03606.10 CDI80508.1 - 5.2 5.1 6.1 1.9 6.6 1.4 2.2 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier Raffinose_syn PF05691.7 CDI80509.1 - 0.0028 15.2 0.0 0.0028 15.2 0.0 1.7 2 0 0 2 2 2 1 Raffinose synthase or seed imbibition protein Sip1 DUF1980 PF09323.5 CDI80509.1 - 0.0088 15.8 2.1 0.0088 15.8 1.5 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1980) OATP PF03137.15 CDI80509.1 - 0.016 13.2 11.7 0.074 11.0 2.9 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TT_ORF1 PF02956.9 CDI80509.1 - 0.1 11.0 11.1 0.24 9.7 2.7 2.3 2 0 0 2 2 2 0 TT viral orf 1 N6_N4_Mtase PF01555.13 CDI80509.1 - 0.19 11.1 0.0 18 4.6 0.0 2.3 1 1 1 2 2 2 0 DNA methylase Glycos_transf_2 PF00535.21 CDI80509.1 - 0.32 10.6 0.0 0.6 9.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 FHIPEP PF00771.15 CDI80509.1 - 0.68 8.1 16.1 1.5 7.0 4.2 2.7 2 0 0 2 2 2 0 FHIPEP family Hid1 PF12722.2 CDI80509.1 - 0.83 7.2 18.2 0.45 8.1 6.5 2.3 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Zip PF02535.17 CDI80509.1 - 2.4 7.1 6.6 0.72 8.7 0.9 2.4 3 0 0 3 3 3 0 ZIP Zinc transporter SAGA-Tad1 PF12767.2 CDI80509.1 - 5.5 6.5 40.0 0.089 12.4 1.7 4.1 4 0 0 4 4 4 0 Transcriptional regulator of RNA polII, SAGA, subunit OmpH PF03938.9 CDI80511.1 - 0.0013 18.6 18.4 0.0013 18.6 12.8 4.8 5 0 0 5 5 5 2 Outer membrane protein (OmpH-like) F-box PF00646.28 CDI80511.1 - 0.019 14.6 1.5 0.055 13.1 1.1 1.9 1 0 0 1 1 1 0 F-box domain SAPS PF04499.10 CDI80511.1 - 0.019 13.6 19.4 0.21 10.1 0.4 2.7 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein RNA_pol_Rpb1_2 PF00623.15 CDI80511.1 - 0.15 12.0 0.1 0.15 12.0 0.0 3.2 3 0 0 3 3 3 0 RNA polymerase Rpb1, domain 2 Ribosomal_60s PF00428.14 CDI80512.1 - 0.012 15.9 21.7 0.2 12.0 3.1 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Chorion_2 PF03964.10 CDI80512.1 - 4 8.0 14.0 7.8 7.1 1.3 2.3 2 0 0 2 2 2 0 Chorion family 2 HEAT PF02985.17 CDI80513.1 - 7.4e-11 41.1 62.7 0.00018 21.3 0.1 15.4 15 0 0 15 15 15 5 HEAT repeat HEAT_2 PF13646.1 CDI80513.1 - 2.5e-09 37.2 43.1 2.2e-05 24.6 4.3 15.0 9 5 5 15 15 15 5 HEAT repeats Vac14_Fab1_bd PF12755.2 CDI80513.1 - 1.5e-05 25.2 0.0 0.59 10.5 0.0 6.0 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CDI80513.1 - 0.0061 17.0 2.8 0.0061 17.0 1.9 26.9 18 5 11 29 29 29 9 HEAT-like repeat PalH PF08733.5 CDI80513.1 - 0.053 12.3 1.6 0.097 11.4 1.1 1.4 1 0 0 1 1 1 0 PalH/RIM21 Kelch_4 PF13418.1 CDI80514.1 - 6.3e-23 80.2 0.1 3.1e-05 23.6 0.0 6.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 CDI80514.1 - 1.8e-20 72.5 0.7 0.0035 17.4 0.0 8.1 8 1 0 8 8 8 6 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI80514.1 - 6.6e-15 54.6 0.0 8.5e-07 28.7 0.0 5.7 6 0 0 6 6 6 2 Kelch motif Ras PF00071.17 CDI80514.1 - 1.8e-14 53.4 2.1 3e-08 33.2 0.1 2.3 1 1 1 2 2 2 2 Ras family Kelch_6 PF13964.1 CDI80514.1 - 9.1e-12 44.6 0.0 1.4e-05 25.0 0.0 4.9 5 0 0 5 5 4 2 Kelch motif Kelch_2 PF07646.10 CDI80514.1 - 1.6e-08 33.9 2.2 0.099 12.4 0.0 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 CDI80514.1 - 1.9e-05 24.0 0.1 0.019 14.5 0.0 4.3 5 0 0 5 5 5 1 Kelch motif NACHT PF05729.7 CDI80514.1 - 0.003 17.2 0.1 0.0071 16.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Miro PF08477.8 CDI80514.1 - 0.0041 17.6 0.0 0.0099 16.3 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein DUF258 PF03193.11 CDI80514.1 - 0.018 14.2 0.2 0.034 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RAG2 PF03089.9 CDI80514.1 - 0.02 13.6 0.0 2 7.0 0.0 3.0 3 0 0 3 3 3 0 Recombination activating protein 2 AAA_22 PF13401.1 CDI80514.1 - 0.066 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Septin PF00735.13 CDI80514.1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Septin Arf PF00025.16 CDI80514.1 - 0.14 11.4 0.4 2.2 7.5 0.1 2.2 1 1 1 2 2 2 0 ADP-ribosylation factor family AAA_16 PF13191.1 CDI80514.1 - 1.6 8.6 9.2 0.32 10.9 2.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain TALPID3 PF15324.1 CDI80514.1 - 3.3 4.9 8.9 1.6 5.9 1.6 2.6 2 0 0 2 2 2 0 Hedgehog signalling target DUF966 PF06136.8 CDI80514.1 - 5.3 6.3 13.3 0.043 13.2 0.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF966) Secretin_N_2 PF07655.8 CDI80514.1 - 6.5 7.2 16.9 0.15 12.4 3.4 3.0 3 0 0 3 3 3 0 Secretin N-terminal domain AP2 PF00847.15 CDI80515.1 - 0.00043 20.3 1.3 0.00043 20.3 0.9 6.7 11 0 0 11 11 11 1 AP2 domain Acyltransferase PF01553.16 CDI80517.1 - 0.21 11.0 0.0 0.54 9.7 0.0 1.6 1 0 0 1 1 1 0 Acyltransferase HCO3_cotransp PF00955.16 CDI80517.1 - 1.3 7.6 6.4 2.4 6.6 4.4 1.4 1 0 0 1 1 1 0 HCO3- transporter family PAT1 PF09770.4 CDI80518.1 - 0.0022 16.3 40.6 0.0025 16.1 28.2 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI80518.1 - 0.0041 15.3 63.9 0.0054 15.0 44.3 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Parvo_coat PF00740.13 CDI80518.1 - 0.27 10.1 17.9 0.3 10.0 12.4 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP2 CRT10 PF08728.5 CDI80518.1 - 0.52 8.2 6.4 0.59 8.0 4.5 1.0 1 0 0 1 1 1 0 CRT10 CDC45 PF02724.9 CDI80518.1 - 0.54 8.2 16.4 0.76 7.7 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF3449 PF11931.3 CDI80518.1 - 0.69 9.3 18.6 0.22 11.0 4.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Hid1 PF12722.2 CDI80518.1 - 0.91 7.1 20.7 1.2 6.7 14.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HPIH PF13323.1 CDI80518.1 - 2.2 7.9 13.5 0.11 12.1 3.6 2.2 2 0 0 2 2 2 0 N-terminal domain with HPIH motif DUF1183 PF06682.7 CDI80518.1 - 2.2 7.8 23.4 1.1 8.7 14.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1183) DUF3337 PF11816.3 CDI80518.1 - 3.2 7.0 19.6 5.7 6.2 13.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) DUF3513 PF12026.3 CDI80519.1 - 0.017 14.6 12.9 0.018 14.5 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) Vfa1 PF08432.5 CDI80519.1 - 0.025 14.5 13.1 0.028 14.4 9.1 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FimP PF09766.4 CDI80519.1 - 0.062 12.3 12.1 0.063 12.3 8.4 1.2 1 0 0 1 1 1 0 Fms-interacting protein DUF2217 PF10265.4 CDI80519.1 - 0.13 10.9 15.7 0.14 10.8 10.9 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF1635 PF07795.6 CDI80519.1 - 0.19 11.0 15.5 0.24 10.7 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) FAM60A PF15396.1 CDI80519.1 - 0.23 11.2 13.6 0.27 10.9 9.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF572 PF04502.8 CDI80519.1 - 0.3 10.2 17.1 0.36 10.0 11.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Plasmodium_Vir PF05795.6 CDI80519.1 - 0.34 10.0 8.3 0.37 9.9 5.8 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FAM222A PF15258.1 CDI80519.1 - 0.44 9.7 15.6 0.48 9.5 10.8 1.0 1 0 0 1 1 1 0 Protein family of FAM222A SAGA-Tad1 PF12767.2 CDI80519.1 - 0.46 10.0 14.8 0.56 9.8 10.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF605 PF04652.11 CDI80519.1 - 0.53 9.6 15.2 0.62 9.3 10.6 1.1 1 0 0 1 1 1 0 Vta1 like Autophagy_N PF03986.8 CDI80519.1 - 0.59 9.8 12.0 0.72 9.6 8.3 1.1 1 0 0 1 1 1 0 Autophagocytosis associated protein (Atg3), N-terminal domain Nop14 PF04147.7 CDI80519.1 - 0.64 7.8 12.1 0.73 7.6 8.4 1.0 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.8 CDI80519.1 - 0.66 8.6 23.3 0.78 8.4 16.2 1.0 1 0 0 1 1 1 0 Paf1 Med15 PF09606.5 CDI80519.1 - 0.68 8.0 23.3 0.66 8.0 16.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal AF-4 PF05110.8 CDI80519.1 - 0.73 7.6 29.1 0.88 7.3 20.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Spore_coat_CotO PF14153.1 CDI80519.1 - 0.76 9.1 13.7 0.97 8.8 9.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Zip PF02535.17 CDI80519.1 - 0.94 8.4 6.2 1.2 8.0 4.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.10 CDI80519.1 - 0.96 8.0 13.6 1 7.8 9.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SelP_N PF04592.9 CDI80519.1 - 1 8.7 12.5 1.2 8.5 8.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Nucleo_P87 PF07267.6 CDI80519.1 - 1 7.9 10.9 1.1 7.8 7.6 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SRP-alpha_N PF04086.8 CDI80519.1 - 1.1 8.5 17.7 1.3 8.3 12.3 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal NPR3 PF03666.8 CDI80519.1 - 1.2 7.6 18.6 1.4 7.3 12.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HSD3 PF15244.1 CDI80519.1 - 1.6 7.9 13.7 1.8 7.7 9.5 1.0 1 0 0 1 1 1 0 Hydroxy-steroid dehydrogenase Ycf1 PF05758.7 CDI80519.1 - 1.7 6.2 10.7 1.8 6.1 7.4 1.0 1 0 0 1 1 1 0 Ycf1 Ribosomal_60s PF00428.14 CDI80519.1 - 1.7 9.1 7.0 3.5 8.0 4.8 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Sporozoite_P67 PF05642.6 CDI80519.1 - 1.8 6.3 15.0 2 6.1 10.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2052 PF09747.4 CDI80519.1 - 1.9 8.3 16.5 2.2 8.1 11.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DDRGK PF09756.4 CDI80519.1 - 2 7.8 13.4 2.2 7.6 9.3 1.1 1 0 0 1 1 1 0 DDRGK domain Pox_Ag35 PF03286.9 CDI80519.1 - 2 7.8 12.8 2.7 7.4 8.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Spc7_N PF15402.1 CDI80519.1 - 2.1 6.2 27.4 2.6 5.9 19.0 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF4557 PF15101.1 CDI80519.1 - 3 7.6 15.4 3.9 7.2 10.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Cwf_Cwc_15 PF04889.7 CDI80519.1 - 3.3 7.3 19.9 3.9 7.1 13.8 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pal1 PF08316.6 CDI80519.1 - 3.4 8.1 8.7 5.1 7.5 6.0 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein CDC45 PF02724.9 CDI80519.1 - 3.7 5.4 21.0 4.6 5.1 14.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.4 CDI80519.1 - 4.1 5.5 22.6 4.9 5.3 15.7 1.0 1 0 0 1 1 1 0 Transmembrane protein IncA PF04156.9 CDI80519.1 - 4.2 6.9 14.7 4.8 6.7 10.2 1.1 1 0 0 1 1 1 0 IncA protein Lin-8 PF03353.10 CDI80519.1 - 4.5 6.4 19.4 5.3 6.2 13.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SpoIIIAH PF12685.2 CDI80519.1 - 4.5 6.7 16.0 5.3 6.4 11.1 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein CMV_1a PF12467.3 CDI80519.1 - 4.8 7.5 13.6 5.6 7.2 9.5 1.0 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family DUF4175 PF13779.1 CDI80519.1 - 4.9 4.7 26.0 5.2 4.6 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Mem_trans PF03547.13 CDI80519.1 - 5 5.3 13.1 5.4 5.2 9.1 1.0 1 0 0 1 1 1 0 Membrane transport protein FLO_LFY PF01698.11 CDI80519.1 - 5.1 5.8 12.6 5.9 5.6 8.8 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Paramyxo_ncap PF00973.14 CDI80519.1 - 5.3 5.6 13.4 6 5.4 9.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Orbi_VP6 PF01516.11 CDI80519.1 - 6.4 5.7 12.3 7.5 5.5 8.5 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 DNA_pol_viral_N PF00242.12 CDI80519.1 - 6.5 5.6 21.3 7.6 5.4 14.8 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain RAP1 PF07218.6 CDI80519.1 - 7 4.6 18.1 7.9 4.4 12.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SID-1_RNA_chan PF13965.1 CDI80519.1 - 7.1 4.6 8.1 7.3 4.6 5.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hid1 PF12722.2 CDI80519.1 - 8.4 3.9 19.4 9.4 3.7 13.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TRAP_alpha PF03896.11 CDI80519.1 - 9.5 5.1 7.9 11 4.8 5.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Apt1 PF10351.4 CDI80519.1 - 9.6 4.9 19.7 11 4.6 13.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain WD40 PF00400.27 CDI80520.1 - 2.2e-15 55.8 7.4 1.9e-06 27.5 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat CRAL_TRIO PF00650.15 CDI80523.1 - 9.3e-09 34.9 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DHHA1 PF02272.14 CDI80523.1 - 0.0028 17.3 0.1 0.011 15.4 0.1 2.0 1 0 0 1 1 1 1 DHHA1 domain Cytochrom_B_N PF00033.14 CDI80524.1 - 0.0073 15.6 2.9 0.0073 15.6 2.0 1.7 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB BatA PF07584.6 CDI80524.1 - 0.17 12.0 0.4 0.17 12.0 0.3 2.2 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Ni_hydr_CYTB PF01292.15 CDI80524.1 - 0.29 10.5 6.8 0.12 11.7 2.8 1.8 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 SIT PF15330.1 CDI80525.1 - 0.0038 17.3 0.0 0.0068 16.5 0.0 1.4 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT TMEM154 PF15102.1 CDI80525.1 - 0.034 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family CD34_antigen PF06365.7 CDI80525.1 - 0.22 11.1 0.0 0.32 10.6 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family LSR PF05624.9 CDI80525.1 - 1.3 8.8 3.2 2.1 8.1 2.2 1.3 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) DUF676 PF05057.9 CDI80527.1 - 3.9e-22 78.6 0.0 1.1e-21 77.1 0.0 1.8 1 1 1 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 CDI80527.1 - 4.8e-09 36.4 3.9 4.8e-09 36.4 2.7 3.9 4 1 0 4 4 4 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDI80527.1 - 9.1e-07 28.7 2.1 9.1e-07 28.7 1.4 4.1 4 1 0 4 4 4 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 CDI80527.1 - 0.0021 17.6 0.1 0.0068 16.0 0.0 1.8 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.15 CDI80527.1 - 0.0057 16.2 0.1 0.0057 16.2 0.1 2.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold RRM_6 PF14259.1 CDI80528.1 - 0.0069 16.3 0.0 0.017 15.1 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI80528.1 - 0.016 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF566 PF04484.7 CDI80528.1 - 0.76 9.2 16.5 0.98 8.8 11.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) PPDK_N PF01326.14 CDI80530.1 - 4.6e-15 55.4 0.0 1.6e-08 34.0 0.0 2.0 2 0 0 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain RRM_1 PF00076.17 CDI80531.1 - 1.5e-20 72.6 0.2 3.4e-20 71.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.7 CDI80531.1 - 6.7e-18 65.0 25.0 6.7e-18 65.0 17.3 3.3 2 1 1 3 3 2 1 Protein of unknown function (DUF1777) RRM_6 PF14259.1 CDI80531.1 - 4.5e-15 55.3 0.0 8.6e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.3 CDI80531.1 - 9.1e-14 51.5 2.4 9.1e-14 51.5 1.7 3.0 3 0 0 3 3 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_5 PF13893.1 CDI80531.1 - 2.8e-10 39.8 0.0 5.1e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4407 PF14362.1 CDI80531.1 - 0.0074 15.2 5.8 0.011 14.6 4.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Ribosomal_60s PF00428.14 CDI80531.1 - 0.032 14.6 3.7 0.068 13.5 2.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein FDF PF09532.5 CDI80531.1 - 0.32 11.5 6.2 5.3 7.6 3.0 2.8 1 1 1 2 2 2 0 FDF domain Anth_synt_I_N PF04715.8 CDI80531.1 - 1.2 9.1 3.6 2.4 8.1 0.0 2.4 2 1 0 2 2 2 0 Anthranilate synthase component I, N terminal region Phostensin_N PF13916.1 CDI80531.1 - 2.4 8.2 17.5 1.7 8.7 1.7 4.2 4 0 0 4 4 4 0 PP1-regulatory protein, Phostensin N-terminal UPF0542 PF15086.1 CDI80531.1 - 6.4 6.5 5.8 1.4 8.7 0.1 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 AP2 PF00847.15 CDI80532.1 - 5.2e-06 26.5 0.9 5.2e-06 26.5 0.6 8.4 11 0 0 11 11 11 1 AP2 domain Cu-binding_MopE PF11617.3 CDI80532.1 - 0.1 12.3 4.2 0.25 11.1 2.9 1.6 1 0 0 1 1 1 0 Protein metal binding site N2227 PF07942.7 CDI80534.1 - 0.035 13.0 0.0 0.061 12.2 0.0 1.4 1 0 0 1 1 1 0 N2227-like protein SidE PF12252.3 CDI80534.1 - 0.066 10.5 0.2 0.088 10.1 0.1 1.4 1 1 0 1 1 1 0 Dot/Icm substrate protein FlaC_arch PF05377.6 CDI80534.1 - 0.11 12.4 0.0 2.5 8.0 0.0 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) GTP_EFTU PF00009.22 CDI80536.1 - 6.5e-60 201.7 0.0 8.4e-60 201.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CDI80536.1 - 1.8e-24 85.7 0.0 3.6e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CDI80536.1 - 1.3e-11 44.4 0.0 2.6e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDI80536.1 - 2.5e-05 24.2 0.0 5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MobB PF03205.9 CDI80536.1 - 0.0087 15.7 0.3 0.63 9.7 0.1 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU_D4 PF14578.1 CDI80536.1 - 0.0094 15.5 0.1 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Miro PF08477.8 CDI80536.1 - 0.022 15.2 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein AAA_29 PF13555.1 CDI80536.1 - 0.031 13.7 0.2 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain cobW PF02492.14 CDI80536.1 - 0.16 11.3 0.4 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ependymin PF00811.13 CDI80536.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Ependymin Mqo PF06039.10 CDI80537.1 - 8.5e-06 24.2 0.0 1.1e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.19 CDI80537.1 - 2.2e-05 23.5 0.0 2.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CDI80537.1 - 0.0048 16.8 0.1 0.0096 15.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Flavodoxin_5 PF12724.2 CDI80537.1 - 0.013 15.5 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin domain 3Beta_HSD PF01073.14 CDI80537.1 - 0.026 13.2 0.0 0.035 12.8 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox_2 PF07992.9 CDI80537.1 - 0.081 12.7 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PGI PF00342.14 CDI80540.1 - 1.8e-183 610.4 0.0 2.1e-183 610.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Peptidase_S8 PF00082.17 CDI80544.1 - 2.6e-38 131.8 5.4 2.6e-38 131.8 3.7 5.5 4 2 0 4 4 4 1 Subtilase family NAP PF00956.13 CDI80546.1 - 5.4e-67 225.4 1.3 5.4e-67 225.4 0.9 1.8 1 1 1 2 2 2 1 Nucleosome assembly protein (NAP) SDA1 PF05285.7 CDI80546.1 - 2.9 7.0 10.2 5.8 6.1 7.1 1.5 1 0 0 1 1 1 0 SDA1 RNA_pol_L PF01193.19 CDI80547.1 - 1.5e-09 36.8 0.0 2.6e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.21 CDI80547.1 - 4.2e-06 26.9 0.0 6.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain KR PF08659.5 CDI80547.1 - 0.0082 15.8 0.1 0.02 14.5 0.1 1.7 1 0 0 1 1 1 1 KR domain Herpes_capsid PF06112.6 CDI80547.1 - 0.18 11.8 22.6 0.39 10.7 15.7 1.7 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein RPN7 PF10602.4 CDI80548.1 - 8.2e-32 109.9 1.0 1.2e-31 109.4 0.7 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 CDI80548.1 - 3.4e-07 30.5 0.0 7e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.1 CDI80548.1 - 0.038 13.7 0.0 0.23 11.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Adaptin_N PF01602.15 CDI80549.1 - 1.2e-66 225.1 0.0 2.6e-33 115.1 0.1 2.5 2 1 0 2 2 2 2 Adaptin N terminal region HEAT_2 PF13646.1 CDI80549.1 - 1.4e-05 25.2 18.7 7.7e-05 22.9 1.0 5.6 7 1 1 8 8 8 2 HEAT repeats HEAT PF02985.17 CDI80549.1 - 0.047 13.7 14.0 2.7 8.3 0.0 6.7 8 0 0 8 8 8 0 HEAT repeat HEAT_EZ PF13513.1 CDI80549.1 - 3.5 8.2 15.4 0.24 11.9 2.0 5.1 5 0 0 5 5 5 0 HEAT-like repeat XPG_I PF00867.13 CDI80550.1 - 1.5e-29 101.8 0.0 3e-29 100.9 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 CDI80550.1 - 1.8e-25 89.1 0.0 3e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 CDI80550.1 - 1.5e-07 31.5 0.0 4.9e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold DUF892 PF05974.7 CDI80550.1 - 0.0075 16.1 0.2 0.017 14.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF892) tify PF06200.9 CDI80550.1 - 0.12 11.6 0.1 0.26 10.5 0.1 1.5 1 0 0 1 1 1 0 tify domain CLTH PF10607.4 CDI80552.1 - 1.6e-13 50.5 0.5 1.8e-10 40.7 0.0 2.1 1 1 1 2 2 2 2 CTLH/CRA C-terminal to LisH motif domain DAGAT PF03982.8 CDI80554.1 - 3.5e-38 130.9 0.0 4.5e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase PLDc_2 PF13091.1 CDI80555.1 - 0.031 14.0 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 PLD-like domain FdhE PF04216.7 CDI80555.1 - 0.11 12.1 3.3 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation Pex14_N PF04695.8 CDI80556.1 - 0.019 15.0 1.6 0.019 15.0 1.1 4.6 4 1 0 5 5 5 0 Peroxisomal membrane anchor protein (Pex14p) conserved region G0-G1_switch_2 PF15103.1 CDI80556.1 - 8.6 6.6 20.1 1.1 9.5 3.5 3.8 3 0 0 3 3 3 0 G0/G1 switch protein 2 Actin PF00022.14 CDI80559.1 - 3.3e-45 154.1 0.0 2.5e-37 128.2 0.0 2.4 2 1 0 2 2 2 2 Actin SMC_N PF02463.14 CDI80560.1 - 4.1e-24 85.0 20.8 3.3e-23 82.0 14.4 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDI80560.1 - 8.1e-12 45.6 0.2 5.4e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain SMC_hinge PF06470.8 CDI80560.1 - 9.7e-10 38.4 0.2 9.7e-10 38.4 0.1 3.0 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.1 CDI80560.1 - 7.6e-09 35.1 0.0 4.1e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain SbcCD_C PF13558.1 CDI80560.1 - 4.2e-05 23.3 1.2 4.2e-05 23.3 0.8 3.4 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit Activator_LAG-3 PF11498.3 CDI80561.1 - 0.003 16.3 7.1 0.003 16.3 4.9 10.4 7 3 2 9 9 9 2 Transcriptional activator LAG-3 FtsJ PF01728.14 CDI80561.1 - 0.69 9.8 16.1 0.015 15.3 3.4 3.7 2 2 1 3 3 3 0 FtsJ-like methyltransferase Dynactin_p22 PF07426.6 CDI80563.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Dynactin subunit p22 UCH PF00443.24 CDI80564.1 - 6e-30 104.2 0.2 4.6e-25 88.2 0.0 3.4 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDI80564.1 - 1e-05 25.1 0.0 1e-05 25.1 0.0 4.0 5 0 0 5 5 5 2 Ubiquitin carboxyl-terminal hydrolase Acetyltransf_1 PF00583.19 CDI80565.1 - 0.0086 16.0 0.2 0.019 14.9 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family tRNA-synt_2 PF00152.15 CDI80566.1 - 4.9e-86 288.5 0.0 8.2e-86 287.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDI80566.1 - 1.7e-09 37.3 0.0 3.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 CDI80566.1 - 3.4e-08 33.0 0.0 2e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 CDI80566.1 - 0.00093 18.8 0.1 0.19 11.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HSP90 PF00183.13 CDI80567.1 - 1.4e-21 76.5 0.3 6.8e-13 47.8 0.0 2.0 1 1 1 2 2 2 2 Hsp90 protein Myosin_head PF00063.16 CDI80568.1 - 1e-175 585.6 6.6 1.7e-175 584.9 4.6 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.14 CDI80568.1 - 3.9e-05 23.2 2.1 8.6e-05 22.1 1.5 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.1 CDI80568.1 - 0.0042 17.0 0.1 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CDI80568.1 - 0.0048 17.0 0.0 0.015 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDI80568.1 - 0.015 14.3 0.1 0.04 13.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin IQ PF00612.22 CDI80568.1 - 0.024 14.2 10.2 0.5 10.1 0.2 3.6 3 0 0 3 3 3 0 IQ calmodulin-binding motif AAA_19 PF13245.1 CDI80568.1 - 0.036 13.8 0.0 0.086 12.5 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain CbiA PF01656.18 CDI80568.1 - 0.048 13.0 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 CDI80568.1 - 0.17 12.7 0.1 1 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain SR-25 PF10500.4 CDI80570.1 - 1.1 8.6 5.8 2.2 7.6 4.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 2-Hacid_dh_C PF02826.14 CDI80571.1 - 1.2e-11 44.1 0.0 1.7e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CDI80571.1 - 0.00086 18.7 0.0 0.27 10.6 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.12 CDI80571.1 - 0.013 15.8 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AP2 PF00847.15 CDI80573.1 - 4.4e-07 29.9 0.7 4.4e-07 29.9 0.5 2.3 2 0 0 2 2 2 1 AP2 domain IncA PF04156.9 CDI80573.1 - 0.0014 18.3 8.0 0.002 17.7 5.5 1.4 1 0 0 1 1 1 1 IncA protein Serinc PF03348.10 CDI80573.1 - 0.08 11.6 4.6 0.1 11.3 3.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.17 CDI80573.1 - 0.49 9.3 3.3 0.77 8.7 2.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_U57 PF05582.7 CDI80573.1 - 0.66 8.9 9.0 0.88 8.4 6.2 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF3276 PF11680.3 CDI80573.1 - 1.1 9.0 11.9 1.7 8.4 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) DDHD PF02862.12 CDI80573.1 - 1.2 8.8 10.5 1.8 8.2 7.3 1.2 1 0 0 1 1 1 0 DDHD domain Cellulose_synt PF03552.9 CDI80573.1 - 1.9 6.6 8.0 2.5 6.3 5.5 1.0 1 0 0 1 1 1 0 Cellulose synthase Band_3_cyto PF07565.8 CDI80573.1 - 3.4 7.1 12.6 5.1 6.5 8.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Hid1 PF12722.2 CDI80573.1 - 5.3 4.5 12.4 6.4 4.3 8.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_S49_N PF08496.5 CDI80573.1 - 7.2 6.3 15.7 11 5.7 10.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PS_Dcarbxylase PF02666.10 CDI80575.1 - 2.4e-14 53.1 0.2 1.2e-06 27.9 0.0 3.8 3 1 1 4 4 4 3 Phosphatidylserine decarboxylase Apolipoprotein PF01442.13 CDI80575.1 - 0.00015 21.3 5.5 0.00021 20.8 2.5 2.0 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain TFIIA PF03153.8 CDI80575.1 - 0.037 13.9 4.7 0.051 13.4 3.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IF4E PF01652.13 CDI80576.1 - 1.7e-07 30.9 0.0 3.1e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E SpoIIID PF12116.3 CDI80576.1 - 0.22 11.4 0.1 0.43 10.5 0.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein D Chorein_N PF12624.2 CDI80577.1 - 5.5e-13 48.4 0.0 1.1e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF1162 PF06650.7 CDI80577.1 - 1.5e-11 44.0 0.0 1.9e-10 40.4 0.0 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1162) Lin0512_fam PF09585.5 CDI80577.1 - 0.061 12.8 0.0 0.28 10.7 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) Myticin-prepro PF10690.4 CDI80579.1 - 0.085 12.8 0.2 0.21 11.6 0.2 1.7 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel MscS_TM PF12794.2 CDI80579.1 - 0.17 10.4 0.1 0.17 10.4 0.1 2.8 3 0 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 RskA PF10099.4 CDI80579.1 - 0.32 10.7 11.6 0.096 12.4 5.9 1.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Med15 PF09606.5 CDI80579.1 - 6.6 4.7 54.8 0.95 7.5 26.6 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SNF2_N PF00176.18 CDI80581.1 - 2.5e-37 128.2 1.7 9.2e-29 100.1 0.0 2.9 3 0 0 3 3 3 2 SNF2 family N-terminal domain F_actin_cap_B PF01115.12 CDI80583.1 - 1.3e-17 63.8 0.0 1.4e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit DUF2034 PF10356.4 CDI80584.1 - 0.0094 15.1 0.1 0.029 13.5 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Reo_sigmaC PF04582.7 CDI80588.1 - 4.6e-06 26.0 12.0 7.7e-06 25.3 2.2 2.1 2 0 0 2 2 2 2 Reovirus sigma C capsid protein Syntaxin-6_N PF09177.6 CDI80588.1 - 0.0035 17.7 6.8 0.0035 17.7 4.7 3.2 3 1 1 4 4 4 1 Syntaxin 6, N-terminal DUF1664 PF07889.7 CDI80588.1 - 0.0048 16.6 5.2 0.0048 16.6 3.6 3.6 3 2 2 5 5 5 1 Protein of unknown function (DUF1664) GAS PF13851.1 CDI80588.1 - 0.0077 15.4 10.8 0.0077 15.4 7.5 3.7 2 2 1 4 4 4 1 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.7 CDI80588.1 - 0.05 13.4 11.4 2.6 7.8 3.6 3.5 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2935 PF11155.3 CDI80588.1 - 0.081 13.0 3.5 2.9 7.9 1.1 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) IncA PF04156.9 CDI80588.1 - 0.1 12.2 37.2 0.069 12.7 2.5 4.0 1 1 1 4 4 4 0 IncA protein KR PF08659.5 CDI80588.1 - 0.13 11.9 6.7 0.24 11.0 0.5 2.7 2 1 1 3 3 3 0 KR domain BLOC1_2 PF10046.4 CDI80588.1 - 0.16 12.1 20.0 0.85 9.7 0.3 4.6 2 2 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Scaffolding_pro PF11418.3 CDI80588.1 - 0.41 10.9 12.4 0.36 11.1 4.1 3.0 2 1 0 2 2 2 0 Phi29 scaffolding protein DUF948 PF06103.6 CDI80588.1 - 1 9.2 7.2 0.77 9.6 0.7 3.5 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.6 CDI80588.1 - 1.1 7.8 22.4 0.0087 14.7 6.9 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.4 CDI80588.1 - 2.8 6.8 19.8 0.095 11.6 7.4 2.4 2 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Laminin_II PF06009.7 CDI80588.1 - 4.2 7.1 19.0 1.8 8.3 0.1 3.8 2 2 2 4 4 4 0 Laminin Domain II ATG16 PF08614.6 CDI80588.1 - 6.6 6.4 30.5 0.12 12.1 10.8 3.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) ISG65-75 PF11727.3 CDI80588.1 - 9.8 5.1 12.7 0.085 11.9 1.4 2.4 2 0 0 2 2 2 0 Invariant surface glycoprotein WD40 PF00400.27 CDI80589.1 - 3.7e-29 99.5 33.9 5.8e-07 29.1 1.0 12.3 13 1 0 13 13 13 7 WD domain, G-beta repeat PQQ_3 PF13570.1 CDI80589.1 - 4.3e-05 23.6 6.1 4.1 7.7 0.0 7.2 8 1 0 8 8 8 1 PQQ-like domain PQQ_2 PF13360.1 CDI80589.1 - 4.8e-05 22.9 0.0 0.024 14.1 0.0 3.2 1 1 3 4 4 4 3 PQQ-like domain Reg_prop PF07494.6 CDI80589.1 - 0.024 14.6 0.1 29 5.1 0.0 4.2 4 0 0 4 4 4 0 Two component regulator propeller PD40 PF07676.7 CDI80589.1 - 0.13 11.9 0.0 49 3.7 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Glyco_hydro_77 PF02446.12 CDI80590.1 - 2e-44 152.0 0.2 2.2e-27 95.8 0.0 2.1 2 0 0 2 2 2 2 4-alpha-glucanotransferase VIT1 PF01988.14 CDI80592.1 - 0.13 11.6 0.0 0.13 11.6 0.0 2.7 3 0 0 3 3 3 0 VIT family Macoilin PF09726.4 CDI80594.1 - 0.00083 17.7 53.5 0.00094 17.5 32.3 2.3 2 0 0 2 2 2 2 Transmembrane protein Ins_P5_2-kin PF06090.7 CDI80594.1 - 0.0025 16.9 31.9 2.1 7.3 18.2 5.1 2 1 0 2 2 2 2 Inositol-pentakisphosphate 2-kinase GAGA_bind PF06217.7 CDI80594.1 - 0.0037 17.2 14.1 0.0037 17.2 9.8 2.9 3 0 0 3 3 3 1 GAGA binding protein-like family Mem_trans PF03547.13 CDI80594.1 - 4.4 5.4 12.4 2 6.5 0.3 2.4 2 0 0 2 2 2 0 Membrane transport protein tRNA_m1G_MT PF01746.16 CDI80595.1 - 1.4e-20 73.6 0.1 6.3e-20 71.5 0.0 2.0 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase TPR_19 PF14559.1 CDI80596.1 - 0.0087 16.3 1.1 5.6 7.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDI80596.1 - 0.021 15.2 3.3 10 6.8 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 CDI80596.1 - 0.18 11.9 3.2 8.2 6.6 0.1 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 CDI80596.1 - 0.22 11.5 4.8 19 5.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 CDI80596.1 - 6.4 7.5 7.7 3.3 8.4 0.6 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat WPP PF13943.1 CDI80597.1 - 0.095 12.9 2.8 0.27 11.4 0.0 2.8 3 0 0 3 3 3 0 WPP domain Chorion_2 PF03964.10 CDI80597.1 - 0.18 12.3 0.9 0.44 11.1 0.7 1.6 1 0 0 1 1 1 0 Chorion family 2 Glyco_transf_8C PF08437.5 CDI80597.1 - 0.18 11.8 1.3 0.31 11.1 0.1 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal DSPc PF00782.15 CDI80598.1 - 0.045 13.3 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain WD40 PF00400.27 CDI80599.1 - 2.7e-16 58.7 0.4 8.8e-10 38.0 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.3 CDI80599.1 - 0.09 10.8 0.0 0.1 10.6 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Reo_sigmaC PF04582.7 CDI80600.1 - 0.015 14.5 1.9 0.02 14.0 0.3 1.8 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF1515 PF07439.6 CDI80600.1 - 3.3 7.5 13.6 2 8.2 1.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) BLOC1_2 PF10046.4 CDI80600.1 - 5.7 7.1 10.2 4.5 7.4 0.1 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 WEMBL PF05701.6 CDI80601.1 - 8.7e-05 21.1 21.7 8.7e-05 21.1 15.0 3.1 2 1 1 3 3 3 1 Weak chloroplast movement under blue light CENP-F_leu_zip PF10473.4 CDI80601.1 - 0.02 14.7 7.2 0.02 14.7 5.0 5.3 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IlvC PF01450.14 CDI80601.1 - 0.028 14.3 0.7 0.028 14.3 0.5 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain V_ATPase_I PF01496.14 CDI80601.1 - 1.9 6.2 24.1 0.23 9.2 4.8 2.5 2 1 0 2 2 2 0 V-type ATPase 116kDa subunit family Reo_sigmaC PF04582.7 CDI80601.1 - 7.6 5.6 14.4 1 8.4 0.3 3.7 2 2 2 4 4 4 0 Reovirus sigma C capsid protein Toxin_41 PF15521.1 CDI80602.1 - 0.0083 15.3 0.2 0.022 13.9 0.1 1.7 1 0 0 1 1 1 1 Putative toxin 41 CRF PF00473.12 CDI80602.1 - 2.8 8.1 7.9 1.4 9.1 1.3 3.3 2 0 0 2 2 2 0 Corticotropin-releasing factor family GAS PF13851.1 CDI80602.1 - 8.5 5.5 36.2 0.063 12.4 0.5 4.9 3 2 0 4 4 4 0 Growth-arrest specific micro-tubule binding DHC_N1 PF08385.7 CDI80603.1 - 9.8e-76 255.3 0.2 4.7e-75 253.1 0.0 2.1 2 1 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 SSFA2_C PF14723.1 CDI80603.1 - 0.022 14.4 2.1 0.13 12.0 0.6 2.6 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus AAA_6 PF12774.2 CDI80604.1 - 2.2e-71 240.0 0.3 3.6e-39 134.6 0.1 2.3 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region D1 DHC_N2 PF08393.8 CDI80604.1 - 9.4e-59 198.9 0.7 1.3e-29 102.9 1.9 2.3 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 2 AAA_5 PF07728.9 CDI80604.1 - 1.6e-06 27.9 0.0 0.0081 15.8 0.0 3.7 2 2 1 3 3 3 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CDI80604.1 - 5.7e-05 23.9 1.0 0.37 11.6 0.0 3.5 3 2 0 3 3 3 2 AAA domain AAA_33 PF13671.1 CDI80604.1 - 0.0011 18.9 0.0 0.44 10.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 CDI80604.1 - 0.0043 17.2 0.0 0.018 15.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 CDI80604.1 - 0.13 11.8 0.8 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CDI80604.1 - 0.13 11.9 0.3 0.43 10.3 0.2 1.8 1 0 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 CDI80604.1 - 0.14 11.2 0.0 1.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Dynein_heavy PF03028.10 CDI80605.1 - 1.2e-81 274.8 0.0 7.5e-29 100.3 0.0 4.4 2 2 2 4 4 4 4 Dynein heavy chain and region D6 of dynein motor MT PF12777.2 CDI80605.1 - 2.3e-56 191.0 6.7 3.3e-56 190.5 4.7 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.2 CDI80605.1 - 6.5e-55 185.9 0.0 1.2e-54 185.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 CDI80605.1 - 3.4e-41 140.5 2.2 1.4e-19 69.8 0.0 3.0 3 0 0 3 3 3 2 ATP-binding dynein motor region D5 AAA_7 PF12775.2 CDI80605.1 - 3.4e-14 52.5 0.0 7.9e-08 31.7 0.0 2.4 1 1 0 2 2 2 2 P-loop containing dynein motor region D3 AAA_5 PF07728.9 CDI80605.1 - 0.0076 15.9 0.0 1.3 8.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ARA70 PF12489.3 CDI80605.1 - 0.11 12.4 3.3 0.29 11.0 2.3 1.7 1 0 0 1 1 1 0 Nuclear coactivator Tctex-1 PF03645.8 CDI80606.1 - 3.4e-19 68.5 0.0 8.9e-19 67.2 0.0 1.8 1 0 0 1 1 1 1 Tctex-1 family WD40 PF00400.27 CDI80606.1 - 4.5e-09 35.8 3.8 2 8.3 0.3 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat POTRA_1 PF08478.5 CDI80606.1 - 0.025 14.6 0.0 3.6 7.6 0.0 2.8 2 0 0 2 2 2 0 POTRA domain, FtsQ-type GCC2_GCC3 PF07699.8 CDI80607.1 - 1.1 8.9 51.8 0.49 10.0 0.6 8.5 7 2 1 8 8 8 0 GCC2 and GCC3 GCC2_GCC3 PF07699.8 CDI80608.1 - 0.00014 21.3 38.1 0.0031 17.0 1.9 5.1 2 2 2 4 4 4 3 GCC2 and GCC3 Lustrin_cystein PF14625.1 CDI80608.1 - 0.0052 16.8 50.6 0.35 10.9 0.0 7.6 4 2 4 8 8 8 5 Lustrin, cysteine-rich repeated domain NCD3G PF07562.9 CDI80608.1 - 4 7.2 22.9 0.44 10.2 2.2 4.6 2 2 2 4 4 4 0 Nine Cysteines Domain of family 3 GPCR NHL PF01436.16 CDI80609.1 - 7.5e-11 41.4 5.6 0.0069 16.2 0.2 4.9 4 0 0 4 4 4 4 NHL repeat GCC2_GCC3 PF07699.8 CDI80609.1 - 0.00056 19.4 0.9 0.00056 19.4 0.6 3.1 3 0 0 3 3 3 1 GCC2 and GCC3 Lustrin_cystein PF14625.1 CDI80609.1 - 6.8 6.8 24.6 0.62 10.1 0.5 4.8 3 1 1 4 4 4 0 Lustrin, cysteine-rich repeated domain Pkinase PF00069.20 CDI80611.1 - 2.5e-45 154.6 0.0 1.6e-44 152.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80611.1 - 5e-19 68.3 0.0 1.5e-13 50.4 0.0 2.2 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 CDI80611.1 - 3.9 7.1 15.2 1.6 8.4 6.2 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family SSP160 PF06933.6 CDI80612.1 - 0.13 10.2 17.9 0.19 9.6 12.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CDP-OH_P_transf PF01066.16 CDI80612.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.7 2 1 0 2 2 2 0 CDP-alcohol phosphatidyltransferase DUF566 PF04484.7 CDI80612.1 - 0.25 10.8 12.1 0.37 10.2 8.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) Macoilin PF09726.4 CDI80612.1 - 0.72 8.0 12.2 1.2 7.3 8.4 1.4 1 0 0 1 1 1 0 Transmembrane protein Ribosomal_60s PF00428.14 CDI80612.1 - 1 9.8 16.6 3.6 8.0 8.0 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cupin_4 PF08007.7 CDI80613.1 - 3.1e-09 36.5 0.0 4e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.1 CDI80613.1 - 0.00089 18.8 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain AraC_binding PF02311.14 CDI80613.1 - 0.0037 16.9 0.0 0.0064 16.1 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.2 CDI80613.1 - 0.0037 16.8 0.6 0.023 14.2 0.0 2.1 2 0 0 2 2 2 1 Cupin Cupin_2 PF07883.6 CDI80613.1 - 0.0074 15.7 0.0 0.015 14.7 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.7 CDI80613.1 - 0.076 12.4 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF861) eIF-5a PF01287.15 CDI80615.1 - 4.9e-26 90.4 0.1 7.3e-26 89.9 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 CDI80615.1 - 0.0053 16.5 0.1 0.011 15.6 0.0 1.6 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain eIF_4EBP PF05456.6 CDI80616.1 - 0.084 12.5 3.3 0.09 12.4 2.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pap_E4 PF02711.9 CDI80616.1 - 0.49 11.2 6.2 0.55 11.0 4.3 1.0 1 0 0 1 1 1 0 E4 protein Med3 PF11593.3 CDI80616.1 - 7.4 5.6 9.5 6.2 5.9 6.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4175 PF13779.1 CDI80616.1 - 8.5 3.9 14.1 8.5 3.9 9.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Zip PF02535.17 CDI80617.1 - 4.9e-05 22.4 2.5 0.011 14.7 0.0 2.6 2 0 0 2 2 2 2 ZIP Zinc transporter Med19 PF10278.4 CDI80617.1 - 0.00081 19.1 3.1 0.00081 19.1 2.2 3.7 4 0 0 4 4 4 1 Mediator of RNA pol II transcription subunit 19 Ycf1 PF05758.7 CDI80617.1 - 0.018 12.8 18.3 0.15 9.7 3.5 2.5 2 0 0 2 2 2 0 Ycf1 CD20 PF04103.10 CDI80617.1 - 0.065 13.1 0.0 0.065 13.1 0.0 6.2 7 2 1 8 8 8 0 CD20-like family SAPS PF04499.10 CDI80617.1 - 1 7.8 23.4 0.38 9.3 3.7 3.2 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein FTR PF01913.13 CDI80617.1 - 1.4 8.6 6.4 0.54 9.9 1.1 2.6 2 0 0 2 2 2 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase Plasmodium_Vir PF05795.6 CDI80617.1 - 2.3 7.3 16.9 11 5.1 0.8 3.4 3 0 0 3 3 3 0 Plasmodium vivax Vir protein Mss4 PF04421.8 CDI80617.1 - 4.4 7.2 0.0 4.4 7.2 0.0 3.9 3 0 0 3 3 3 0 Mss4 protein DUF1510 PF07423.6 CDI80617.1 - 5.2 6.3 39.7 0.46 9.8 5.7 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1510) Cation_ATPase_C PF00689.16 CDI80618.1 - 1.9e-08 34.0 3.4 0.0012 18.4 1.2 2.1 1 1 1 2 2 2 2 Cation transporting ATPase, C-terminus DUF1517 PF07466.6 CDI80618.1 - 1.4 7.8 4.0 1.9 7.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) Daxx PF03344.10 CDI80619.1 - 0.003 16.1 43.8 0.0047 15.4 30.4 1.2 1 0 0 1 1 1 1 Daxx Family IncA PF04156.9 CDI80619.1 - 0.017 14.6 13.4 0.032 13.8 9.3 1.5 1 0 0 1 1 1 0 IncA protein Med15 PF09606.5 CDI80619.1 - 0.042 12.0 21.6 0.062 11.5 15.0 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Methyltransf_26 PF13659.1 CDI80619.1 - 0.38 10.7 4.3 40 4.2 3.0 2.7 1 1 0 1 1 1 0 Methyltransferase domain PRP1_N PF06424.7 CDI80620.1 - 3.7 7.8 21.6 0.11 12.7 5.3 2.8 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal WD40 PF00400.27 CDI80621.1 - 2e-53 176.4 14.9 1.5e-11 43.7 1.3 8.0 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 CDI80621.1 - 1.9e-06 26.2 5.1 0.25 9.4 0.4 4.5 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CDI80621.1 - 8.4e-05 21.4 0.2 0.033 12.9 0.0 2.9 2 1 1 3 3 3 2 Nup133 N terminal like Lipase_3 PF01764.20 CDI80622.1 - 4e-18 65.3 0.0 7.9e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 CDI80622.1 - 0.0003 20.7 0.2 0.0011 18.9 0.1 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CDI80622.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.9 CDI80622.1 - 0.038 13.2 0.0 0.064 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 CDI80622.1 - 0.039 13.7 0.1 0.15 11.7 0.0 2.0 2 1 0 2 2 2 0 Alpha/beta hydrolase family Pkinase PF00069.20 CDI80623.1 - 3.1e-69 233.0 0.3 1.2e-68 231.1 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80623.1 - 4e-33 114.5 0.2 1.1e-32 113.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4602 PF15375.1 CDI80624.1 - 0.018 15.1 4.3 0.018 15.1 3.0 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4602) DUF778 PF05608.7 CDI80624.1 - 0.17 11.8 2.1 3.5 7.5 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF778) Fumble PF03630.9 CDI80624.1 - 1.7 7.3 5.1 0.45 9.3 1.5 1.5 2 0 0 2 2 2 0 Fumble PCNP PF15473.1 CDI80624.1 - 4.2 7.6 0.0 4.2 7.6 0.0 3.5 2 1 1 3 3 3 0 PEST, proteolytic signal-containing nuclear protein family PLRV_ORF5 PF01690.12 CDI80624.1 - 5.9 5.9 21.1 6.6 5.7 14.6 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Ndc1_Nup PF09531.5 CDI80624.1 - 9.8 4.4 20.8 21 3.3 14.4 1.5 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AlkA_N PF06029.6 CDI80625.1 - 0.0092 16.0 1.5 0.034 14.2 1.0 2.0 1 0 0 1 1 1 1 AlkA N-terminal domain SIT PF15330.1 CDI80626.1 - 0.099 12.7 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT CECR6_TMEM121 PF14997.1 CDI80627.1 - 6.8e-08 32.3 1.3 1.1e-07 31.6 0.9 1.3 1 0 0 1 1 1 1 CECR6/TMEM121 family Tmem26 PF09772.4 CDI80627.1 - 0.011 14.9 0.2 0.011 14.9 0.1 1.8 2 0 0 2 2 2 0 Transmembrane protein 26 Pex14_N PF04695.8 CDI80627.1 - 0.21 11.6 11.3 0.51 10.3 7.8 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SART-1 PF03343.8 CDI80627.1 - 0.21 9.8 6.9 0.31 9.3 4.8 1.2 1 0 0 1 1 1 0 SART-1 family PAT1 PF09770.4 CDI80627.1 - 7.8 4.6 22.8 4.6 5.3 14.7 1.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 LCCL PF03815.14 CDI80628.1 - 1.1e-07 31.6 0.5 3.1e-07 30.2 0.3 1.7 1 0 0 1 1 1 1 LCCL domain NiFeSe_Hases PF00374.14 CDI80633.1 - 4 6.0 7.8 4.2 6.0 5.4 1.0 1 0 0 1 1 1 0 Nickel-dependent hydrogenase GidB PF02527.10 CDI80633.1 - 6.2 5.9 14.7 13 4.8 10.2 1.6 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G Effector_1 PF04518.7 CDI80633.1 - 9.4 5.1 16.0 9.8 5.0 11.1 1.0 1 0 0 1 1 1 0 Effector from type III secretion system Peptidase_M41 PF01434.13 CDI80634.1 - 8.2e-57 192.1 0.0 1.4e-56 191.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 CDI80634.1 - 3.2e-29 101.7 0.0 7.6e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IATP PF04568.7 CDI80634.1 - 9.4 6.3 18.4 0.034 14.1 1.9 4.0 4 0 0 4 4 4 0 Mitochondrial ATPase inhibitor, IATP Rcd1 PF04078.8 CDI80636.1 - 4.2e-35 120.8 0.2 4.2e-35 120.8 0.1 2.0 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like DUF3474 PF11960.3 CDI80636.1 - 0.4 10.7 10.4 0.15 12.0 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) Shadoo PF14999.1 CDI80636.1 - 0.4 10.5 6.3 0.76 9.6 4.4 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF4407 PF14362.1 CDI80636.1 - 0.8 8.6 26.1 1.2 7.9 18.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Virul_Fac PF10139.4 CDI80636.1 - 3.7 5.3 27.8 4.9 4.9 19.3 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor SMN PF06003.7 CDI80636.1 - 8.7 5.3 13.8 7.5 5.5 8.6 1.6 1 1 1 2 2 2 0 Survival motor neuron protein (SMN) Cytochrom_C PF00034.16 CDI80637.1 - 7.8e-06 26.6 2.6 5.2e-05 23.9 0.0 2.5 2 1 0 2 2 2 1 Cytochrome c Cytochrom_C550 PF14495.1 CDI80637.1 - 0.002 17.6 0.1 0.01 15.2 0.0 2.0 2 0 0 2 2 2 1 Cytochrome c-550 domain Cytochrome_CBB3 PF13442.1 CDI80637.1 - 0.0046 17.0 0.0 0.0087 16.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III AAA_11 PF13086.1 CDI80639.1 - 2.9e-23 82.6 54.8 5.5e-12 45.7 17.1 5.4 3 1 1 4 4 4 2 AAA domain AAA_19 PF13245.1 CDI80639.1 - 9.7e-10 38.0 0.1 9.7e-10 38.0 0.1 4.7 5 0 0 5 5 3 1 Part of AAA domain AAA_25 PF13481.1 CDI80639.1 - 0.0001 21.7 0.0 0.00079 18.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Spore_coat_CotO PF14153.1 CDI80639.1 - 0.00031 20.2 14.6 0.00031 20.2 10.1 5.4 5 1 0 5 5 4 1 Spore coat protein CotO AAA_22 PF13401.1 CDI80639.1 - 0.00094 19.3 0.0 0.00094 19.3 0.0 3.7 4 0 0 4 4 4 1 AAA domain Suf PF05843.9 CDI80639.1 - 0.0049 16.6 20.5 0.0049 16.6 14.2 4.9 5 1 0 5 5 4 1 Suppressor of forked protein (Suf) AAA PF00004.24 CDI80639.1 - 0.0083 16.3 0.0 0.32 11.1 0.0 3.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 CDI80639.1 - 0.011 14.9 0.0 0.51 9.4 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_5 PF07728.9 CDI80639.1 - 0.018 14.7 0.0 0.066 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 CDI80639.1 - 0.05 14.4 0.0 0.28 12.0 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDI80639.1 - 0.27 11.5 0.0 0.27 11.5 0.0 2.9 3 1 0 3 3 2 0 AAA domain Cwf_Cwc_15 PF04889.7 CDI80639.1 - 2.9 7.5 55.8 2.4 7.7 21.2 3.6 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.4 CDI80641.1 - 4.8e-05 22.9 23.9 0.00075 19.0 6.4 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF3801 PF12687.2 CDI80641.1 - 0.087 12.3 4.7 0.033 13.7 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) TFIIA PF03153.8 CDI80641.1 - 0.25 11.2 14.1 0.39 10.5 9.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.9 CDI80641.1 - 0.97 9.1 6.2 0.4 10.3 1.6 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Secretin_N_2 PF07655.8 CDI80641.1 - 5.7 7.3 21.0 1.3 9.4 4.4 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain Ureide_permease PF07168.6 CDI80642.1 - 1.1 7.8 5.4 1.4 7.5 3.7 1.1 1 0 0 1 1 1 0 Ureide permease Pollen_allerg_2 PF01620.11 CDI80642.1 - 1.4 9.2 12.4 1.5 9.1 8.6 1.1 1 0 0 1 1 1 0 Ribonuclease (pollen allergen) AMP-binding PF00501.23 CDI80642.1 - 1.4 7.2 6.4 1.4 7.1 4.4 1.0 1 0 0 1 1 1 0 AMP-binding enzyme FHIPEP PF00771.15 CDI80642.1 - 1.6 6.9 13.8 1.7 6.8 9.6 1.0 1 0 0 1 1 1 0 FHIPEP family DUF3450 PF11932.3 CDI80642.1 - 2 7.6 44.6 2.1 7.5 30.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4175 PF13779.1 CDI80642.1 - 2.5 5.6 49.4 2.5 5.7 34.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UPF0564 PF10595.4 CDI80642.1 - 3.1 6.6 35.4 3.2 6.5 24.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 DUF4557 PF15101.1 CDI80642.1 - 3.4 7.4 32.8 4.8 6.9 22.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Med15 PF09606.5 CDI80642.1 - 5.3 5.1 66.8 5.8 4.9 46.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Herpes_glycop PF01528.11 CDI80642.1 - 9 4.8 6.6 10 4.6 4.6 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M RNA_pol_Rpb1_5 PF04998.12 CDI80642.1 - 9.4 5.4 12.5 9.7 5.3 8.7 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 YABBY PF04690.8 CDI80642.1 - 9.4 6.4 12.7 11 6.2 8.8 1.2 1 0 0 1 1 1 0 YABBY protein Acyl-CoA_dh_N PF02771.11 CDI80644.1 - 6.2e-22 78.3 0.1 1.2e-21 77.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 CDI80644.1 - 3.1e-17 61.7 0.3 5.2e-17 61.0 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 CDI80644.1 - 0.0045 17.2 0.0 0.0045 17.2 0.0 2.3 2 1 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal TSA PF03249.8 CDI80644.1 - 9.9 4.5 7.5 13 4.1 5.2 1.1 1 0 0 1 1 1 0 Type specific antigen Ribosomal_L1 PF00687.16 CDI80645.1 - 3.2e-14 52.8 0.1 5.1e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Miff PF05644.6 CDI80645.1 - 0.012 15.3 1.4 0.017 14.8 1.0 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff DNA_pol_viral_N PF00242.12 CDI80645.1 - 1 8.2 4.2 1.5 7.7 2.9 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Herpes_capsid PF06112.6 CDI80645.1 - 1.1 9.2 6.7 1.9 8.5 4.7 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CDC45 PF02724.9 CDI80646.1 - 0.00015 19.9 14.2 0.00015 19.9 9.8 2.5 2 1 0 2 2 2 1 CDC45-like protein CAF-1_p150 PF11600.3 CDI80646.1 - 0.00044 19.6 39.6 0.00044 19.6 27.5 2.8 3 0 0 3 3 3 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal SR-25 PF10500.4 CDI80647.1 - 0.017 14.6 12.4 0.024 14.0 8.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 CDI80647.1 - 0.13 12.3 12.9 0.23 11.5 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF2217 PF10265.4 CDI80647.1 - 2 7.0 15.0 1.2 7.8 9.2 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF2146 PF10220.4 CDI80647.1 - 3.9 5.3 6.7 5 4.9 4.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Med15 PF09606.5 CDI80648.1 - 1.2e-05 23.8 32.1 1.5e-05 23.4 22.2 1.4 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI80648.1 - 0.021 12.5 6.0 0.022 12.4 4.1 1.0 1 0 0 1 1 1 0 Ycf1 XRN_N PF03159.13 CDI80648.1 - 0.024 14.0 5.2 0.028 13.8 3.6 1.1 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus FimP PF09766.4 CDI80648.1 - 0.04 13.0 20.6 0.053 12.5 14.3 1.1 1 0 0 1 1 1 0 Fms-interacting protein eIF-3_zeta PF05091.7 CDI80648.1 - 0.066 11.8 14.8 0.073 11.6 10.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HemX PF04375.9 CDI80648.1 - 0.072 11.6 19.3 0.084 11.4 13.4 1.2 1 0 0 1 1 1 0 HemX DUF2048 PF09752.4 CDI80648.1 - 0.075 11.8 4.6 0.098 11.5 3.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Peptidase_S15 PF02129.13 CDI80648.1 - 0.095 12.0 8.9 0.12 11.7 6.2 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Plasmodium_Vir PF05795.6 CDI80648.1 - 0.12 11.5 9.7 0.15 11.2 6.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Draxin PF15550.1 CDI80648.1 - 0.16 11.6 12.0 0.19 11.3 8.3 1.1 1 0 0 1 1 1 0 Draxin PAT1 PF09770.4 CDI80648.1 - 0.2 9.8 40.4 0.19 9.9 28.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NARP1 PF12569.3 CDI80648.1 - 0.21 10.3 10.2 0.24 10.0 7.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MAP65_ASE1 PF03999.7 CDI80648.1 - 0.22 10.0 23.3 0.3 9.6 15.9 1.4 1 1 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Tim54 PF11711.3 CDI80648.1 - 0.27 9.7 7.2 0.28 9.7 5.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM222A PF15258.1 CDI80648.1 - 0.54 9.4 33.3 0.67 9.1 23.1 1.2 1 0 0 1 1 1 0 Protein family of FAM222A TFIIA PF03153.8 CDI80648.1 - 0.59 9.9 34.1 0.72 9.6 23.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_transf_15 PF01793.11 CDI80648.1 - 0.8 8.5 9.6 0.92 8.3 6.6 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase DUF853 PF05872.7 CDI80648.1 - 1.6 7.0 9.4 1.7 6.8 6.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF4407 PF14362.1 CDI80648.1 - 1.6 7.6 15.7 1.9 7.3 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4175 PF13779.1 CDI80648.1 - 1.6 6.3 39.0 2.1 5.9 27.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RR_TM4-6 PF06459.7 CDI80648.1 - 1.7 8.5 12.6 2.4 7.9 8.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Macoilin PF09726.4 CDI80648.1 - 1.8 6.7 27.3 2.1 6.5 18.9 1.0 1 0 0 1 1 1 0 Transmembrane protein SAGA-Tad1 PF12767.2 CDI80648.1 - 2.2 7.8 23.5 2.7 7.5 16.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Cellulose_synt PF03552.9 CDI80648.1 - 2.5 6.2 4.1 2.7 6.1 2.9 1.0 1 0 0 1 1 1 0 Cellulose synthase Spore_YhcN_YlaJ PF09580.5 CDI80648.1 - 2.6 8.1 11.6 3 7.9 8.1 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF3450 PF11932.3 CDI80648.1 - 2.9 7.0 23.6 4.5 6.4 16.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF106 PF01956.11 CDI80648.1 - 2.9 7.3 5.4 3.3 7.2 3.8 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 RED_N PF07808.8 CDI80648.1 - 2.9 7.0 17.5 4.7 6.3 12.2 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region Spc7_N PF15402.1 CDI80648.1 - 3 5.7 31.6 3.8 5.4 21.9 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 SAPS PF04499.10 CDI80648.1 - 3.3 6.2 13.7 3.7 6.0 9.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1183 PF06682.7 CDI80648.1 - 3.8 7.0 21.3 4.9 6.6 14.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Peptidase_S49_N PF08496.5 CDI80648.1 - 3.9 7.2 11.3 5.7 6.7 7.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_U57 PF05582.7 CDI80648.1 - 8.6 5.2 10.5 12 4.7 7.3 1.1 1 0 0 1 1 1 0 YabG peptidase U57 CDK5_activator PF03261.10 CDI80648.1 - 9.3 5.4 23.0 12 5.1 15.9 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein MMR1 PF08505.5 CDI80648.1 - 9.5 6.1 32.0 12 5.8 22.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Pantoate_ligase PF02569.10 CDI80650.1 - 6.3e-29 100.6 0.0 1.4e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Acetyltransf_7 PF13508.1 CDI80650.1 - 0.006 16.7 0.1 0.014 15.5 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CDI80650.1 - 0.02 14.9 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Ribosomal_60s PF00428.14 CDI80650.1 - 8.7 6.8 54.4 0.097 13.0 1.0 6.4 6 0 0 6 6 6 0 60s Acidic ribosomal protein DDOST_48kD PF03345.9 CDI80652.1 - 2.1e-09 36.4 0.0 1.8e-05 23.5 0.0 2.9 2 1 1 3 3 3 3 Oligosaccharyltransferase 48 kDa subunit beta Peptidase_C14 PF00656.17 CDI80655.1 - 1.5e-32 113.3 0.0 5.3e-32 111.4 0.0 2.0 1 1 0 1 1 1 1 Caspase domain Suf PF05843.9 CDI80656.1 - 3.1 7.4 27.7 0.43 10.2 5.4 3.3 2 1 1 3 3 3 0 Suppressor of forked protein (Suf) Ldh_1_N PF00056.18 CDI80658.1 - 4.1e-38 130.3 0.1 7.4e-38 129.5 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CDI80658.1 - 3.6e-33 114.7 0.0 5.9e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.11 CDI80658.1 - 5.8e-06 25.7 0.2 7.7e-05 22.0 0.0 2.2 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase HTH_18 PF12833.2 CDI80658.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain NMT PF01233.14 CDI80662.1 - 1.7e-65 219.6 0.1 2.2e-65 219.1 0.1 1.1 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.1 CDI80662.1 - 0.00039 20.2 0.0 0.0006 19.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CDI80662.1 - 0.018 15.2 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ycf1 PF05758.7 CDI80663.1 - 1.1 6.8 9.2 1.2 6.7 6.4 1.1 1 0 0 1 1 1 0 Ycf1 DivIC PF04977.10 CDI80663.1 - 2.5 7.6 29.8 0.04 13.3 9.7 2.2 2 0 0 2 2 2 0 Septum formation initiator Dishevelled PF02377.10 CDI80664.1 - 0.039 14.1 1.8 0.039 14.1 1.3 3.3 3 0 0 3 3 3 0 Dishevelled specific domain CDK5_activator PF03261.10 CDI80664.1 - 0.59 9.4 12.7 0.055 12.8 2.4 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein Phostensin_N PF13916.1 CDI80664.1 - 4.5 7.3 10.3 0.39 10.7 1.2 2.2 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DnaJ PF00226.26 CDI80665.1 - 3.7e-29 100.2 0.7 3.7e-29 100.2 0.5 1.8 2 0 0 2 2 2 1 DnaJ domain GHMP_kinases_N PF00288.21 CDI80665.1 - 0.015 15.3 0.6 0.029 14.4 0.4 1.4 1 0 0 1 1 1 0 GHMP kinases N terminal domain CDK2AP PF09806.4 CDI80665.1 - 0.031 14.5 0.4 0.039 14.1 0.3 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein APP_E2 PF12925.2 CDI80665.1 - 0.039 13.5 0.4 0.066 12.7 0.2 1.3 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein Ribosomal_60s PF00428.14 CDI80665.1 - 0.059 13.7 3.5 0.09 13.1 2.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF1217 PF06748.7 CDI80665.1 - 0.14 12.2 1.4 2 8.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1217) PPI_Ypi1 PF07491.6 CDI80667.1 - 2.9e-21 74.8 0.1 2.9e-21 74.8 0.1 1.5 2 0 0 2 2 2 1 Protein phosphatase inhibitor SR-25 PF10500.4 CDI80667.1 - 0.00022 20.7 11.1 0.00031 20.2 7.7 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF3446 PF11928.3 CDI80667.1 - 0.1 12.7 11.4 0.19 11.9 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) MTBP_C PF14920.1 CDI80667.1 - 0.91 8.9 9.9 1.9 7.9 6.9 1.5 1 1 0 1 1 1 0 MDM2-binding DUF3827 PF12877.2 CDI80667.1 - 2.1 6.3 6.4 2.4 6.1 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Kinase-like PF14531.1 CDI80668.1 - 8.8e-11 41.2 0.0 3e-10 39.5 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI80668.1 - 2e-06 27.0 0.0 3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 CDI80668.1 - 2.4e-06 26.9 0.0 7e-06 25.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain DUF3597 PF12200.3 CDI80668.1 - 0.12 12.8 0.1 0.49 10.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Pkinase PF00069.20 CDI80669.1 - 7.1e-12 45.0 0.0 9.2e-12 44.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI80669.1 - 6.1e-11 41.8 0.0 9.3e-11 41.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI80669.1 - 1.7e-06 27.2 0.0 2.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HlyIII PF03006.15 CDI80670.1 - 5.5e-19 68.4 16.4 7.3e-19 68.0 11.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3591 PF12157.3 CDI80672.1 - 4.1e-17 61.7 0.0 2.4e-08 32.8 0.0 3.5 3 1 0 3 3 3 3 Protein of unknown function (DUF3591) Bromodomain PF00439.20 CDI80672.1 - 9.2e-13 47.9 0.0 1.8e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain zf-CCHC_6 PF15288.1 CDI80672.1 - 0.0005 19.6 1.0 0.0013 18.3 0.7 1.7 1 0 0 1 1 1 1 Zinc knuckle EF-hand_10 PF14788.1 CDI80672.1 - 0.32 10.6 1.2 5.9 6.6 0.0 2.6 2 0 0 2 2 2 0 EF hand Patched PF02460.13 CDI80674.1 - 7.2e-99 331.8 4.2 7.7e-63 212.6 0.4 3.2 3 1 0 3 3 3 2 Patched family Sterol-sensing PF12349.3 CDI80674.1 - 7.5e-28 96.9 5.2 7.5e-28 96.9 3.6 2.4 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.14 CDI80674.1 - 7.6e-07 26.9 11.1 1.8e-06 25.7 7.7 1.5 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family DUF4525 PF15027.1 CDI80674.1 - 0.02 14.3 0.6 0.07 12.6 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Ank_2 PF12796.2 CDI80675.1 - 1.5e-32 111.7 0.7 4.3e-10 39.8 0.6 5.8 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 CDI80675.1 - 1.4e-31 106.7 15.7 3.8e-07 29.5 0.0 10.0 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.1 CDI80675.1 - 3.6e-20 71.5 13.4 0.0048 17.1 0.0 9.2 6 2 3 10 10 10 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI80675.1 - 1.9e-17 61.6 11.6 0.015 15.4 0.0 9.6 10 0 0 10 10 10 6 Ankyrin repeat Ank_4 PF13637.1 CDI80675.1 - 1.2e-15 57.4 6.7 0.01 16.3 0.0 7.6 4 2 4 8 8 8 6 Ankyrin repeats (many copies) cEGF PF12662.2 CDI80676.1 - 0.016 14.8 0.7 0.039 13.5 0.5 1.7 1 0 0 1 1 1 0 Complement Clr-like EGF-like TIL PF01826.12 CDI80676.1 - 0.055 13.5 2.0 0.098 12.7 1.4 1.4 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain Adaptin_binding PF10199.4 CDI80677.1 - 0.0055 16.9 8.7 0.0055 16.9 6.0 6.7 5 3 0 5 5 5 1 Alpha and gamma adaptin binding protein p34 Na_H_Exchanger PF00999.16 CDI80685.1 - 1.8e-28 99.1 21.3 1.8e-28 99.1 14.8 1.8 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family XAP5 PF04921.9 CDI80686.1 - 5.9e-79 265.0 22.5 9.2e-79 264.3 1.0 2.7 2 1 1 3 3 3 2 XAP5, circadian clock regulator PAP1 PF08601.5 CDI80686.1 - 0.037 13.7 17.3 0.054 13.1 12.0 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Ndc1_Nup PF09531.5 CDI80686.1 - 0.27 9.6 8.1 0.37 9.1 5.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3534 PF12053.3 CDI80686.1 - 3.5 7.5 8.4 7.9 6.3 5.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3534) FAM220 PF15487.1 CDI80686.1 - 6.6 6.0 18.7 12 5.1 12.9 1.3 1 0 0 1 1 1 0 FAM220 family DUF572 PF04502.8 CDI80686.1 - 7.3 5.7 34.2 1.8 7.7 20.6 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF572) AP2 PF00847.15 CDI80687.1 - 8.8e-07 28.9 7.0 8.8e-07 28.9 4.9 4.4 5 0 0 5 5 5 1 AP2 domain CAF-1_p150 PF11600.3 CDI80688.1 - 0.014 14.8 11.0 0.016 14.6 7.7 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Med15 PF09606.5 CDI80688.1 - 0.025 12.8 20.0 0.026 12.7 13.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF737 PF05300.6 CDI80688.1 - 0.17 11.8 8.3 0.21 11.5 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) PAT1 PF09770.4 CDI80688.1 - 0.22 9.7 12.8 0.21 9.8 8.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF605 PF04652.11 CDI80688.1 - 0.26 10.6 15.7 0.3 10.4 10.9 1.0 1 0 0 1 1 1 0 Vta1 like TAF1D PF15333.1 CDI80688.1 - 0.48 10.1 4.6 0.57 9.9 3.2 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D TFIIA PF03153.8 CDI80688.1 - 0.89 9.3 12.2 0.96 9.2 8.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4603 PF15376.1 CDI80688.1 - 0.92 6.6 11.7 1 6.4 8.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) dsDNA_bind PF01984.15 CDI80688.1 - 1.2 9.1 14.7 1.8 8.6 10.2 1.2 1 0 0 1 1 1 0 Double-stranded DNA-binding domain DUF2890 PF11081.3 CDI80688.1 - 1.3 9.0 9.8 1.5 8.8 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) CDK5_activator PF03261.10 CDI80688.1 - 1.4 8.2 7.6 1.5 8.0 5.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein bZIP_C PF12498.3 CDI80688.1 - 2.5 9.3 12.0 3 9.0 8.3 1.1 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Suf PF05843.9 CDI80688.1 - 3.4 7.3 11.8 3.7 7.1 8.2 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3043 PF11241.3 CDI80688.1 - 5.2 6.6 6.4 6.4 6.3 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) BaxI_1 PF12811.2 CDI80688.1 - 6.2 5.8 5.2 7.9 5.5 3.6 1.1 1 0 0 1 1 1 0 Bax inhibitor 1 like Herpes_DNAp_acc PF04929.7 CDI80688.1 - 7.9 5.3 9.7 8.5 5.2 6.7 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor TPR_1 PF00515.23 CDI80690.1 - 0.0016 17.9 3.9 0.16 11.6 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat SR-25 PF10500.4 CDI80690.1 - 0.0052 16.2 15.3 0.0052 16.2 10.6 6.6 8 1 0 8 8 8 3 Nuclear RNA-splicing-associated protein Zip PF02535.17 CDI80690.1 - 0.014 14.4 0.4 0.014 14.4 0.3 3.7 4 1 0 4 4 4 0 ZIP Zinc transporter TPR_8 PF13181.1 CDI80690.1 - 0.022 14.5 0.3 0.25 11.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDI80690.1 - 0.22 11.5 17.0 0.022 14.6 0.7 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Ycf1 PF05758.7 CDI80690.1 - 1.2 6.7 10.7 0.1 10.2 0.6 2.3 2 0 0 2 2 2 0 Ycf1 tRNA-synt_2b PF00587.20 CDI80693.1 - 1.6e-39 135.2 0.1 2.7e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDI80693.1 - 5.7e-17 61.4 0.0 1.5e-16 60.1 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.9 CDI80693.1 - 4.1e-12 45.7 0.0 1.1e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 CDI80693.1 - 4.1e-09 36.1 0.0 0.00013 21.7 0.0 2.4 2 0 0 2 2 2 2 TGS domain Rotamase_2 PF13145.1 CDI80693.1 - 5.6 7.6 12.2 7.5 7.2 0.3 3.0 3 0 0 3 3 3 0 PPIC-type PPIASE domain AAA_23 PF13476.1 CDI80694.1 - 0.0031 17.8 10.5 0.48 10.7 4.9 2.3 2 0 0 2 2 2 2 AAA domain CDC45 PF02724.9 CDI80694.1 - 3.4 5.5 11.2 0.7 7.8 3.6 2.1 2 0 0 2 2 2 0 CDC45-like protein Spore_coat_CotO PF14153.1 CDI80694.1 - 3.8 6.9 25.5 4.1 6.8 11.3 2.8 2 0 0 2 2 2 0 Spore coat protein CotO RskA PF10099.4 CDI80695.1 - 0.00012 21.8 2.1 0.00031 20.5 1.3 1.7 2 0 0 2 2 2 1 Anti-sigma-K factor rskA Zn_peptidase PF04228.8 CDI80695.1 - 0.001 18.3 0.6 0.001 18.3 0.4 1.7 2 0 0 2 2 2 1 Putative neutral zinc metallopeptidase YL1 PF05764.8 CDI80695.1 - 0.011 15.3 17.9 0.022 14.3 11.5 1.7 1 1 1 2 2 2 0 YL1 nuclear protein Daxx PF03344.10 CDI80695.1 - 0.06 11.8 15.8 0.066 11.6 11.0 1.0 1 0 0 1 1 1 0 Daxx Family Nop53 PF07767.6 CDI80695.1 - 0.24 10.3 17.4 0.34 9.8 12.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TFIIF_alpha PF05793.7 CDI80695.1 - 0.31 9.3 16.5 0.41 8.9 11.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ETRAMP PF09716.5 CDI80695.1 - 0.63 10.0 6.6 0.52 10.3 0.1 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4557 PF15101.1 CDI80695.1 - 0.68 9.7 14.0 0.19 11.5 3.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) DUF4407 PF14362.1 CDI80695.1 - 1.1 8.1 14.1 1.4 7.7 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pex14_N PF04695.8 CDI80695.1 - 1.4 8.9 16.4 0.43 10.6 3.3 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2956 PF11169.3 CDI80695.1 - 1.7 8.6 14.9 0.25 11.3 5.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) SprA-related PF12118.3 CDI80695.1 - 2 7.6 31.6 2.5 7.3 21.9 1.1 1 0 0 1 1 1 0 SprA-related family SAPS PF04499.10 CDI80695.1 - 2 6.9 9.2 2.6 6.5 6.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM176 PF14851.1 CDI80695.1 - 3.4 7.3 8.8 0.58 9.8 1.4 2.1 2 0 0 2 2 2 0 FAM176 family CDC45 PF02724.9 CDI80695.1 - 5.3 4.9 17.1 6.7 4.6 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein FLO_LFY PF01698.11 CDI80695.1 - 9.8 4.9 13.3 14 4.4 9.2 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Ras PF00071.17 CDI80704.1 - 3.8e-19 68.6 0.0 7.9e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Ras family SR-25 PF10500.4 CDI80704.1 - 0.0051 16.3 2.8 0.0051 16.3 2.0 3.0 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF4448 PF14610.1 CDI80704.1 - 9.2 5.7 7.8 12 5.2 0.0 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF4448) FimP PF09766.4 CDI80705.1 - 0.0012 18.0 5.7 0.13 11.2 0.4 2.2 2 0 0 2 2 2 2 Fms-interacting protein DUF2489 PF10675.4 CDI80705.1 - 0.029 14.0 21.4 0.11 12.1 5.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) 60KD_IMP PF02096.15 CDI80705.1 - 0.24 11.0 6.3 1.7 8.2 0.1 2.2 2 0 0 2 2 2 0 60Kd inner membrane protein DUF775 PF05603.7 CDI80705.1 - 0.27 10.7 16.8 0.11 12.0 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Citrate_synt PF00285.16 CDI80705.1 - 0.86 8.2 11.9 0.53 8.9 3.9 2.1 1 1 1 2 2 2 0 Citrate synthase RAB3GAP2_N PF14655.1 CDI80705.1 - 1.1 8.2 17.6 0.86 8.5 2.6 2.3 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF202 PF02656.10 CDI80705.1 - 2.3 8.4 0.0 2.3 8.4 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF202) 7tm_1 PF00001.16 CDI80705.1 - 3.9 6.5 4.8 29 3.6 1.3 2.7 2 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DivIC PF04977.10 CDI80705.1 - 5.3 6.5 19.7 4.6 6.7 2.8 2.5 2 0 0 2 2 2 0 Septum formation initiator Afi1 PF07792.7 CDI80705.1 - 9.9 6.1 10.8 3.4 7.6 1.5 2.4 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF932 PF06067.6 CDI80707.1 - 0.011 15.0 1.9 0.013 14.8 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF932) Ribosomal_L19e PF01280.15 CDI80707.1 - 1.5 8.6 7.1 1.9 8.2 4.9 1.3 1 0 0 1 1 1 0 Ribosomal protein L19e Med15_fungi PF05397.7 CDI80708.1 - 0.04 13.9 0.8 0.11 12.5 0.5 1.7 1 0 0 1 1 1 0 Mediator complex subunit 15 WD-3 PF09765.4 CDI80708.1 - 0.2 10.9 1.9 2.6 7.2 0.6 2.2 2 0 0 2 2 2 0 WD-repeat region Spore_III_AB PF09548.5 CDI80708.1 - 1.4 8.5 5.6 0.38 10.4 1.0 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Totivirus_coat PF05518.6 CDI80708.1 - 2.2 6.0 7.7 3.5 5.3 5.3 1.2 1 0 0 1 1 1 0 Totivirus coat protein Mito_fiss_reg PF05308.6 CDI80710.1 - 0.49 9.7 6.6 0.52 9.6 4.5 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3306 PF11748.3 CDI80711.1 - 1.1 9.8 4.3 11 6.6 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Sporozoite_P67 PF05642.6 CDI80711.1 - 2 6.1 13.7 3.3 5.4 9.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4139 PF13598.1 CDI80711.1 - 2.8 7.1 12.9 1.2 8.3 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4139) Exo_endo_phos PF03372.18 CDI80712.1 - 2.5e-11 43.9 0.0 2.9e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SMP PF04927.7 CDI80716.1 - 0.057 13.3 5.8 0.18 11.7 4.0 1.9 1 0 0 1 1 1 0 Seed maturation protein Band_3_cyto PF07565.8 CDI80716.1 - 0.1 12.0 5.5 0.024 14.1 0.5 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain LRR_4 PF12799.2 CDI80717.1 - 1.7e-43 145.5 57.3 1.2e-09 37.5 1.6 7.3 1 1 9 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI80717.1 - 2.4e-37 126.4 56.3 6.1e-10 38.7 1.2 5.4 3 1 5 8 8 8 6 Leucine rich repeat LRR_1 PF00560.28 CDI80717.1 - 4.9e-14 50.2 32.6 0.074 13.1 0.1 10.5 10 1 0 10 10 10 5 Leucine Rich Repeat LRR_6 PF13516.1 CDI80717.1 - 2.2e-13 48.7 20.7 0.36 11.0 0.1 9.3 8 1 1 9 9 9 5 Leucine Rich repeat LRR_7 PF13504.1 CDI80717.1 - 2.3e-12 44.9 24.2 1.5 9.3 0.1 10.3 10 0 0 10 10 10 4 Leucine rich repeat LRR_9 PF14580.1 CDI80717.1 - 2.7e-11 43.3 12.4 1e-06 28.4 1.2 3.9 1 1 3 4 4 4 3 Leucine-rich repeat DUF2322 PF10084.4 CDI80717.1 - 0.59 9.8 2.6 5 6.9 0.1 3.3 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2322) DUF755 PF05501.6 CDI80720.1 - 0.0036 17.3 10.0 0.0051 16.8 6.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF755) Claudin_2 PF13903.1 CDI80720.1 - 0.01 15.5 1.0 0.016 14.9 0.7 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF2561 PF10812.3 CDI80720.1 - 0.029 13.9 8.1 0.048 13.2 5.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2561) Corona_nucleoca PF00937.13 CDI80720.1 - 0.074 11.9 8.7 0.079 11.9 6.0 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Mucin PF01456.12 CDI80720.1 - 0.19 11.4 19.5 0.29 10.9 13.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF966 PF06136.8 CDI80720.1 - 0.23 10.8 9.3 0.27 10.5 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BLVR PF06375.6 CDI80720.1 - 0.34 10.7 4.0 0.46 10.3 2.8 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Atrophin-1 PF03154.10 CDI80720.1 - 0.75 7.8 14.3 0.88 7.6 9.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family PCNP PF15473.1 CDI80720.1 - 1.8 8.8 7.2 2.4 8.4 5.0 1.2 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family DUF1635 PF07795.6 CDI80720.1 - 2.3 7.5 6.1 3 7.1 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Apc1 PF12859.2 CDI80720.1 - 3.2 8.0 6.0 4.8 7.4 4.2 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 DUF3628 PF12300.3 CDI80720.1 - 3.8 7.5 15.6 9.7 6.1 10.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3628) Peptidase_S64 PF08192.6 CDI80720.1 - 5.7 5.1 11.3 6.6 4.9 7.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 TFIIA PF03153.8 CDI80720.1 - 6 6.6 15.5 7.1 6.4 10.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Collagen PF01391.13 CDI80722.1 - 0.011 15.2 5.3 0.018 14.5 3.7 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Nop14 PF04147.7 CDI80722.1 - 2.9 5.6 4.6 3.6 5.3 3.2 1.1 1 0 0 1 1 1 0 Nop14-like family Rotamase_2 PF13145.1 CDI80722.1 - 7.8 7.1 10.0 3.4 8.3 0.3 2.2 2 0 0 2 2 2 0 PPIC-type PPIASE domain Pkinase PF00069.20 CDI80724.1 - 1.8e-67 227.2 0.1 2e-67 227.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80724.1 - 1.1e-39 136.0 0.0 1.3e-39 135.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CDI80724.1 - 2.5e-06 26.7 0.0 3.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CDI80724.1 - 0.0002 20.4 0.9 0.16 10.8 0.3 2.9 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 CDI80724.1 - 0.0014 18.4 0.0 0.014 15.1 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 CDI80724.1 - 0.029 13.7 0.5 0.058 12.7 0.0 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 CDI80724.1 - 0.13 11.8 0.1 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Rtf2 PF04641.7 CDI80727.1 - 9.4 5.3 24.9 10 5.1 17.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger LSM PF01423.17 CDI80728.1 - 2.9e-18 65.1 0.1 5.3e-18 64.3 0.1 1.4 1 0 0 1 1 1 1 LSM domain Dehydrin PF00257.14 CDI80728.1 - 1.1e-05 25.7 7.8 1.6e-05 25.2 5.4 1.4 1 0 0 1 1 1 1 Dehydrin SAPS PF04499.10 CDI80728.1 - 0.0012 17.5 6.7 0.0015 17.2 4.6 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.11 CDI80728.1 - 0.002 18.0 5.3 0.0023 17.8 3.7 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CDK5_activator PF03261.10 CDI80728.1 - 0.0021 17.4 9.5 0.0025 17.2 6.6 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein FAM60A PF15396.1 CDI80728.1 - 0.0041 16.9 3.8 0.0054 16.5 2.7 1.4 1 0 0 1 1 1 1 Protein Family FAM60A DUF2217 PF10265.4 CDI80728.1 - 0.0064 15.3 4.3 0.0072 15.1 3.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2217) GAGA_bind PF06217.7 CDI80728.1 - 0.012 15.5 8.3 0.013 15.4 5.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Spore_coat_CotO PF14153.1 CDI80728.1 - 0.021 14.2 15.8 0.026 13.9 10.9 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Otopetrin PF03189.8 CDI80728.1 - 0.022 13.7 1.0 0.022 13.7 0.7 1.2 1 0 0 1 1 1 0 Otopetrin DUF755 PF05501.6 CDI80728.1 - 0.022 14.7 39.6 0.039 13.9 27.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Mem_trans PF03547.13 CDI80728.1 - 0.024 12.9 2.4 0.025 12.8 1.7 1.1 1 0 0 1 1 1 0 Membrane transport protein UPF0565 PF10561.4 CDI80728.1 - 0.037 12.9 9.1 17 4.1 9.6 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 DUF1645 PF07816.6 CDI80728.1 - 0.11 12.9 8.0 0.2 12.1 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Anoctamin PF04547.7 CDI80728.1 - 0.13 10.8 5.0 0.18 10.4 3.5 1.3 1 0 0 1 1 1 0 Calcium-activated chloride channel LMBR1 PF04791.11 CDI80728.1 - 0.13 10.7 2.1 0.13 10.8 1.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein G-7-MTase PF12803.2 CDI80728.1 - 0.14 11.2 7.8 0.2 10.7 5.4 1.2 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) AUX_IAA PF02309.11 CDI80728.1 - 0.18 11.5 10.4 0.25 11.0 7.2 1.3 1 0 0 1 1 1 0 AUX/IAA family Plasmodium_Vir PF05795.6 CDI80728.1 - 0.19 10.9 5.4 0.24 10.5 3.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FAM220 PF15487.1 CDI80728.1 - 0.21 10.9 13.4 0.3 10.4 9.3 1.2 1 0 0 1 1 1 0 FAM220 family Alg14 PF08660.6 CDI80728.1 - 0.35 10.8 5.3 15 5.5 3.1 2.1 2 0 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like Cwf_Cwc_15 PF04889.7 CDI80728.1 - 0.37 10.4 20.6 0.52 9.9 14.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2422 PF10337.4 CDI80728.1 - 0.38 9.4 5.2 0.52 9.0 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Ycf1 PF05758.7 CDI80728.1 - 0.45 8.1 12.1 0.53 7.9 8.4 1.0 1 0 0 1 1 1 0 Ycf1 Selenoprotein_S PF06936.6 CDI80728.1 - 0.53 9.7 16.1 0.71 9.3 11.2 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) DUF4407 PF14362.1 CDI80728.1 - 1.5 7.7 20.1 2 7.2 13.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDRGK PF09756.4 CDI80728.1 - 1.6 8.0 23.0 2.2 7.6 15.9 1.1 1 0 0 1 1 1 0 DDRGK domain Band_3_cyto PF07565.8 CDI80728.1 - 1.8 7.9 19.9 2.5 7.5 13.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Med15 PF09606.5 CDI80728.1 - 2.1 6.4 59.4 2.5 6.1 41.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal AF-4 PF05110.8 CDI80728.1 - 2.1 6.1 21.9 2.5 5.8 15.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAT1 PF09770.4 CDI80728.1 - 2.2 6.4 46.8 2.8 6.0 32.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dehalogenase PF13486.1 CDI80728.1 - 3.2 7.1 9.7 4.5 6.6 6.8 1.2 1 0 0 1 1 1 0 Reductive dehalogenase subunit Lin-8 PF03353.10 CDI80728.1 - 3.5 6.8 21.5 3.4 6.8 14.0 1.5 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Hid1 PF12722.2 CDI80728.1 - 4.2 4.9 21.7 5.2 4.6 15.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HGTP_anticodon2 PF12745.2 CDI80728.1 - 5.1 6.1 15.2 8.2 5.4 10.5 1.3 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Spc7_N PF15402.1 CDI80728.1 - 7 4.5 24.9 9.3 4.1 17.2 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Calici_coat_C PF08435.6 CDI80728.1 - 7.2 5.8 14.5 9.7 5.4 10.0 1.1 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal SLD3 PF08639.5 CDI80728.1 - 7.3 5.1 24.7 9.1 4.7 17.1 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 Dicty_REP PF05086.7 CDI80728.1 - 8.4 4.0 11.5 11 3.6 8.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SAPS PF04499.10 CDI80729.1 - 0.0061 15.2 6.4 0.019 13.6 4.7 1.5 1 1 0 1 1 1 1 SIT4 phosphatase-associated protein Raftlin PF15250.1 CDI80729.1 - 0.09 11.2 14.1 0.17 10.3 8.5 2.0 2 0 0 2 2 2 0 Raftlin SPX PF03105.14 CDI80729.1 - 0.17 11.6 13.7 0.062 13.0 6.7 2.0 2 0 0 2 2 2 0 SPX domain SID-1_RNA_chan PF13965.1 CDI80729.1 - 0.23 9.5 4.8 0.38 8.8 3.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF908 PF06012.7 CDI80729.1 - 5.9 6.0 15.9 11 5.1 11.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) FLO_LFY PF01698.11 CDI80729.1 - 6 5.6 26.2 0.93 8.2 14.4 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein Cellulose_synt PF03552.9 CDI80729.1 - 8.4 4.5 6.1 15 3.7 4.2 1.3 1 0 0 1 1 1 0 Cellulose synthase RNA_pol_Rpb1_5 PF04998.12 CDI80729.1 - 9.2 5.4 8.2 11 5.1 4.8 1.7 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 5 Menin PF05053.8 CDI80730.1 - 0.11 10.6 7.7 0.2 9.7 5.3 1.3 1 0 0 1 1 1 0 Menin Vfa1 PF08432.5 CDI80730.1 - 0.45 10.5 7.7 0.08 12.9 2.3 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Helicase_C PF00271.26 CDI80731.1 - 1.2e-28 98.7 0.0 1.8e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 CDI80731.1 - 0.0072 16.3 0.0 0.0086 16.0 0.0 1.2 1 0 0 1 1 1 1 Helicase C-terminal domain GRP PF07172.6 CDI80731.1 - 0.23 11.9 7.8 0.49 10.8 5.0 1.8 2 0 0 2 2 2 0 Glycine rich protein family Peptidase_M76 PF09768.4 CDI80732.1 - 3.6e-35 120.9 2.2 1.6e-25 89.5 0.1 2.4 2 0 0 2 2 2 2 Peptidase M76 family TFIIA PF03153.8 CDI80732.1 - 2.3 8.0 43.6 2.2 8.0 5.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-DHHC PF01529.15 CDI80733.1 - 0.14 11.5 3.0 2.9 7.2 0.3 3.0 3 0 0 3 3 3 0 DHHC palmitoyltransferase FimP PF09766.4 CDI80733.1 - 0.22 10.5 33.7 0.63 9.0 2.2 3.3 3 0 0 3 3 3 0 Fms-interacting protein TPR_11 PF13414.1 CDI80734.1 - 2.8e-13 49.2 6.0 7.5e-13 47.9 4.1 1.8 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 CDI80734.1 - 8.8e-10 37.7 6.4 5.7e-05 22.5 1.8 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat SPX PF03105.14 CDI80734.1 - 7.5e-09 35.7 19.0 0.012 15.3 0.6 5.3 4 2 1 5 5 5 2 SPX domain TPR_2 PF07719.12 CDI80734.1 - 1.8e-08 33.6 8.9 0.0001 21.9 2.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDI80734.1 - 5.7e-07 29.3 5.9 5.7e-07 29.3 4.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDI80734.1 - 0.0015 18.3 3.3 0.048 13.5 0.3 2.7 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 CDI80734.1 - 0.0083 15.8 1.6 0.08 12.7 0.5 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI80734.1 - 0.012 15.7 3.7 0.042 14.0 0.6 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI80734.1 - 0.034 13.9 5.3 2.1 8.3 0.4 3.3 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF2025 PF09634.5 CDI80734.1 - 0.056 13.2 0.2 0.29 10.8 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2025) TPT PF03151.11 CDI80738.1 - 0.022 14.3 11.0 0.058 13.0 1.9 2.5 2 0 0 2 2 2 0 Triose-phosphate Transporter family RILP PF11461.3 CDI80739.1 - 9.1e-05 22.5 0.6 0.0024 18.0 0.0 3.2 2 0 0 2 2 2 1 Rab interacting lysosomal protein AAA_13 PF13166.1 CDI80739.1 - 0.00028 19.5 6.0 0.00028 19.5 4.1 2.7 2 1 1 3 3 3 1 AAA domain APG6 PF04111.7 CDI80739.1 - 0.00052 19.1 3.3 0.00052 19.1 2.3 4.5 4 1 1 5 5 5 2 Autophagy protein Apg6 Sec8_exocyst PF04048.9 CDI80739.1 - 0.0014 18.2 1.5 0.0014 18.2 1.0 3.1 4 0 0 4 4 4 1 Sec8 exocyst complex component specific domain TSC22 PF01166.13 CDI80739.1 - 0.0025 17.7 15.6 0.22 11.5 0.5 5.4 5 0 0 5 5 5 2 TSC-22/dip/bun family IncA PF04156.9 CDI80739.1 - 0.0054 16.3 1.5 0.0054 16.3 1.1 4.9 4 1 1 5 5 5 2 IncA protein DivIC PF04977.10 CDI80739.1 - 0.014 14.9 0.1 0.014 14.9 0.1 7.6 6 2 2 8 8 8 0 Septum formation initiator HALZ PF02183.13 CDI80739.1 - 0.04 13.6 47.6 0.045 13.4 0.6 8.4 9 0 0 9 9 8 0 Homeobox associated leucine zipper Phage_GP20 PF06810.6 CDI80739.1 - 0.63 9.4 21.9 0.051 13.0 0.5 5.2 5 1 1 6 6 6 0 Phage minor structural protein GP20 DUF342 PF03961.8 CDI80739.1 - 1.8 6.8 23.6 0.14 10.5 0.9 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF342) NPV_P10 PF05531.7 CDI80739.1 - 3.9 7.7 9.3 14 5.9 0.1 4.7 3 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 CDI80739.1 - 4.1 7.3 9.2 11 5.9 0.1 4.3 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) PI3_PI4_kinase PF00454.22 CDI80741.1 - 2.9e-11 43.2 3.7 2.5e-09 36.9 0.4 2.8 2 1 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PP_kinase_N PF13089.1 CDI80741.1 - 0.012 15.6 1.6 0.012 15.6 1.1 4.3 4 0 0 4 4 4 0 Polyphosphate kinase N-terminal domain N6_N4_Mtase PF01555.13 CDI80742.1 - 3.5 7.0 12.5 76 2.6 0.0 4.1 3 2 0 4 4 4 0 DNA methylase DUF572 PF04502.8 CDI80745.1 - 0.55 9.4 59.7 0.66 9.1 41.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PAT1 PF09770.4 CDI80745.1 - 9.3 4.3 82.1 12 3.9 56.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RskA PF10099.4 CDI80746.1 - 6.3e-05 22.7 32.3 0.047 13.4 7.2 3.6 2 1 0 3 3 3 3 Anti-sigma-K factor rskA Yip1 PF04893.12 CDI80746.1 - 0.059 12.8 2.5 12 5.3 2.8 3.1 2 1 0 2 2 2 0 Yip1 domain TMEM52 PF14979.1 CDI80746.1 - 2.9 7.7 9.8 0.14 12.0 0.2 2.9 2 1 0 3 3 3 0 Transmembrane 52 Col_cuticle_N PF01484.12 CDI80746.1 - 3.1 7.5 0.0 3.1 7.5 0.0 3.6 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain Utp12 PF04003.7 CDI80747.1 - 2.3e-06 27.5 3.0 4.9e-06 26.4 2.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ketoacyl-synt PF00109.21 CDI80748.1 - 5e-36 124.4 2.8 1.1e-35 123.3 0.8 2.0 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CDI80748.1 - 6.4e-27 93.7 1.8 1.6e-24 86.0 1.3 2.4 1 1 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CDI80748.1 - 0.0015 17.5 0.8 0.0031 16.5 0.5 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CDI80748.1 - 0.0094 15.5 1.8 4.5 7.0 0.0 3.1 3 0 0 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III CactinC_cactus PF09732.4 CDI80750.1 - 9.1e-52 173.8 7.7 1.7e-51 173.0 5.3 1.5 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.4 CDI80750.1 - 1.1e-36 125.8 3.8 1.1e-36 125.8 2.6 2.9 2 1 0 2 2 2 1 Conserved mid region of cactin Phage_connect_1 PF05135.8 CDI80750.1 - 0.12 12.5 1.8 0.25 11.5 0.2 2.3 2 0 0 2 2 2 0 Phage gp6-like head-tail connector protein Thioesterase PF00975.15 CDI80751.1 - 3.9e-17 63.2 0.1 1.3e-16 61.5 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 CDI80751.1 - 2.5e-11 43.9 0.0 3.2e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDI80751.1 - 1e-08 35.0 0.0 1.6e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF726 PF05277.7 CDI80751.1 - 0.013 14.4 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF2305 PF10230.4 CDI80751.1 - 0.018 14.4 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) PE-PPE PF08237.6 CDI80751.1 - 0.026 13.9 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain DUF900 PF05990.7 CDI80751.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Ribosomal_S4e PF00900.15 CDI80752.1 - 1.6e-28 98.1 0.2 9.1e-28 95.7 0.1 2.1 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 CDI80752.1 - 1.9e-18 66.0 9.6 3.6e-18 65.1 5.6 2.1 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.20 CDI80752.1 - 4.7e-06 25.9 0.0 1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 CDI80752.1 - 1.1e-05 24.9 0.9 1.1e-05 24.9 0.7 2.6 3 0 0 3 3 3 1 KOW motif IPK PF03770.11 CDI80753.1 - 1.8e-25 89.7 0.0 1.6e-24 86.6 0.0 2.0 1 1 0 1 1 1 1 Inositol polyphosphate kinase AMP-binding PF00501.23 CDI80755.1 - 9.2e-35 119.8 0.0 1.3e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Serglycin PF04360.7 CDI80755.1 - 0.0024 17.6 0.4 0.0044 16.7 0.3 1.4 1 0 0 1 1 1 1 Serglycin SR-25 PF10500.4 CDI80755.1 - 0.0065 15.9 0.1 0.0065 15.9 0.1 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein AIG1 PF04548.11 CDI80755.1 - 0.54 9.3 3.3 0.26 10.3 0.2 1.8 2 0 0 2 2 2 0 AIG1 family ACDC PF14733.1 CDI80756.1 - 1e-09 38.3 0.1 1e-09 38.3 0.1 2.1 2 0 0 2 2 2 1 AP2-coincident C-terminal eIF-3_zeta PF05091.7 CDI80756.1 - 1.9 7.0 25.6 2.7 6.5 17.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4544 PF15077.1 CDI80756.1 - 2.9 7.3 9.7 0.23 10.9 3.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4544) CPSF_A PF03178.10 CDI80757.1 - 1.1e-52 179.0 0.0 1.3e-52 178.9 0.0 1.0 1 0 0 1 1 1 1 CPSF A subunit region BPL_LplA_LipB PF03099.14 CDI80759.1 - 8.4e-12 45.1 0.2 6.6e-08 32.6 0.2 2.7 2 0 0 2 2 2 2 Biotin/lipoate A/B protein ligase family Otopetrin PF03189.8 CDI80759.1 - 3.2e-05 23.1 0.7 3.2e-05 23.1 0.5 2.6 2 0 0 2 2 2 1 Otopetrin Spore_coat_CotO PF14153.1 CDI80759.1 - 0.0048 16.3 27.7 0.0048 16.3 19.2 3.2 3 0 0 3 3 3 1 Spore coat protein CotO Ycf1 PF05758.7 CDI80759.1 - 0.11 10.1 36.5 0.17 9.5 14.5 2.5 3 0 0 3 3 3 0 Ycf1 Pox_Ag35 PF03286.9 CDI80759.1 - 0.78 9.2 29.3 1.9 7.9 1.6 3.3 3 0 0 3 3 3 0 Pox virus Ag35 surface protein CDC45 PF02724.9 CDI80759.1 - 1.1 7.2 41.7 0.17 9.9 1.1 3.1 3 0 0 3 3 3 0 CDC45-like protein RAP1 PF07218.6 CDI80759.1 - 4.5 5.2 22.1 0.47 8.5 1.1 2.4 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) HlyD_2 PF12700.2 CDI80759.1 - 9.9 5.2 36.7 7.1 5.6 13.2 2.5 2 0 0 2 2 2 0 HlyD family secretion protein Diphthamide_syn PF01866.12 CDI80760.1 - 2.2e-54 184.8 0.0 2.3e-41 142.0 0.0 2.4 3 0 0 3 3 3 2 Putative diphthamide synthesis protein Cwf_Cwc_15 PF04889.7 CDI80760.1 - 5.1 6.7 16.0 0.31 10.7 4.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RPAP1_C PF08620.5 CDI80762.1 - 7.8e-18 64.1 1.0 9.4e-16 57.4 0.5 3.0 2 0 0 2 2 2 2 RPAP1-like, C-terminal IQ PF00612.22 CDI80763.1 - 0.017 14.7 0.3 0.04 13.5 0.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif TPR_11 PF13414.1 CDI80765.1 - 5.8e-11 41.8 2.9 9e-06 25.2 0.3 2.8 1 1 1 2 2 2 2 TPR repeat TPR_19 PF14559.1 CDI80765.1 - 8e-07 29.3 1.7 2.3e-06 27.8 1.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDI80765.1 - 4.6e-06 26.4 0.8 4.6e-06 26.4 0.5 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDI80765.1 - 5.9e-06 25.7 0.3 0.11 12.5 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDI80765.1 - 1.2e-05 24.7 0.2 0.028 14.0 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDI80765.1 - 1.2e-05 25.8 0.2 1.2e-05 25.8 0.1 4.4 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI80765.1 - 0.00015 22.0 0.3 0.00015 22.0 0.2 4.8 5 1 1 6 6 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDI80765.1 - 0.0045 17.0 0.5 0.017 15.2 0.3 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDI80765.1 - 0.0061 16.4 0.7 0.022 14.6 0.5 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDI80765.1 - 0.0068 16.7 3.3 0.023 15.1 0.1 3.5 4 0 0 4 4 3 1 Tetratricopeptide repeat Apc3 PF12895.2 CDI80765.1 - 0.0092 16.1 4.7 0.013 15.6 1.4 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 CDI80765.1 - 0.024 14.5 0.1 1.4 8.8 0.0 2.9 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.9 CDI80765.1 - 0.063 13.7 0.3 0.063 13.7 0.2 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Prenyltrans_2 PF13249.1 CDI80765.1 - 0.077 13.4 1.1 0.22 11.9 0.3 2.2 2 1 0 2 2 1 0 Prenyltransferase-like Abhydrolase_2 PF02230.11 CDI80767.1 - 3.8e-51 173.6 0.0 8.1e-51 172.5 0.0 1.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CDI80767.1 - 3.8e-09 36.4 0.1 1.2e-08 34.8 0.0 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI80767.1 - 1.7e-07 31.4 0.8 5.4e-07 29.7 0.1 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 CDI80767.1 - 6.5e-05 22.2 0.7 0.00012 21.4 0.0 1.7 2 1 0 2 2 2 1 Esterase PHB depolymerase Abhydrolase_3 PF07859.8 CDI80767.1 - 0.00024 20.7 0.0 0.0014 18.2 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CDI80767.1 - 0.00035 19.8 0.0 0.24 10.5 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase family FSH1 PF03959.8 CDI80767.1 - 0.0023 17.4 0.0 0.0052 16.2 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.15 CDI80767.1 - 0.003 17.1 0.2 0.0086 15.6 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.7 CDI80767.1 - 0.031 12.7 0.1 0.05 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.3 CDI80767.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase SET PF00856.23 CDI80768.1 - 2.1e-07 31.4 0.0 0.0013 19.0 0.0 2.8 2 0 0 2 2 2 2 SET domain Barwin PF00967.12 CDI80768.1 - 0.17 11.5 0.2 0.33 10.6 0.2 1.4 1 0 0 1 1 1 0 Barwin family Abhydrolase_3 PF07859.8 CDI80768.1 - 0.71 9.4 8.9 0.32 10.5 0.5 3.2 3 0 0 3 3 3 0 alpha/beta hydrolase fold SKIP_SNW PF02731.10 CDI80769.1 - 1.7e-63 212.8 1.4 1.7e-63 212.8 1.0 3.1 3 0 0 3 3 3 1 SKIP/SNW domain Kelch_4 PF13418.1 CDI80770.1 - 0.00014 21.5 0.2 0.00042 20.0 0.1 1.9 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI80770.1 - 0.00014 21.7 0.5 0.0014 18.5 0.0 2.9 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.1 CDI80770.1 - 0.086 13.0 10.9 1.9 8.7 0.0 5.3 5 0 0 5 5 5 0 Galactose oxidase, central domain FKS1_dom1 PF14288.1 CDI80772.1 - 0.24 11.3 6.2 0.088 12.7 1.6 2.3 2 0 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF4275 PF14101.1 CDI80772.1 - 0.42 10.6 0.2 1.1 9.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) Amidohydro_2 PF04909.9 CDI80774.1 - 0.2 11.1 3.7 0.26 10.8 2.3 1.6 1 1 0 1 1 1 0 Amidohydrolase Peroxin-22 PF12827.2 CDI80775.1 - 0.017 14.8 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family Sec66 PF09802.4 CDI80776.1 - 1.9e-06 27.4 7.6 1.9e-06 27.4 5.2 2.6 2 1 1 3 3 3 1 Preprotein translocase subunit Sec66 DRMBL PF07522.9 CDI80778.1 - 9.5e-14 51.3 0.0 1.3e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.7 CDI80778.1 - 3.1e-07 30.1 0.0 4.8e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_2 PF12706.2 CDI80778.1 - 0.00033 20.2 0.0 0.07 12.6 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain SPX PF03105.14 CDI80779.1 - 1.1e-31 110.7 0.7 1.1e-31 110.7 0.5 2.9 3 0 0 3 3 3 1 SPX domain DUF202 PF02656.10 CDI80779.1 - 8.5e-11 41.9 6.8 8.5e-11 41.9 4.7 4.4 5 1 1 6 6 6 1 Domain of unknown function (DUF202) VTC PF09359.5 CDI80779.1 - 4.5e-09 35.7 0.0 5.6e-05 22.2 0.0 3.2 2 1 0 2 2 2 2 VTC domain FixQ PF05545.6 CDI80779.1 - 0.032 13.8 0.6 0.076 12.6 0.4 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ RseC_MucC PF04246.7 CDI80780.1 - 0.0016 18.0 0.1 0.003 17.1 0.1 1.5 1 0 0 1 1 1 1 Positive regulator of sigma(E), RseC/MucC DUF21 PF01595.15 CDI80780.1 - 0.0072 15.6 0.2 0.17 11.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF21 TraG_N PF07916.6 CDI80780.1 - 0.0087 14.5 0.9 0.0087 14.5 0.6 2.2 2 0 0 2 2 2 1 TraG-like protein, N-terminal region PBP1_TM PF14812.1 CDI80780.1 - 0.11 12.8 0.1 4 7.8 0.0 2.6 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF912 PF06024.7 CDI80780.1 - 1.9 8.6 0.0 1.9 8.6 0.0 2.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SSP160 PF06933.6 CDI80780.1 - 2.7 5.8 19.1 4.6 5.0 13.2 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CD20 PF04103.10 CDI80780.1 - 3.8 7.4 7.0 4.8 7.1 0.0 2.9 2 1 0 2 2 2 0 CD20-like family YjgP_YjgQ PF03739.9 CDI80780.1 - 4.3 5.9 6.9 10 4.7 4.6 1.9 1 1 0 1 1 1 0 Predicted permease YjgP/YjgQ family Zip PF02535.17 CDI80780.1 - 5.1 6.0 9.7 20 4.0 6.7 2.1 1 1 0 1 1 1 0 ZIP Zinc transporter Med15 PF09606.5 CDI80780.1 - 7.8 4.5 30.9 12 3.9 21.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Med15 PF09606.5 CDI80782.1 - 0.0012 17.1 2.9 0.0012 17.1 2.0 5.0 5 1 0 5 5 5 2 ARC105 or Med15 subunit of Mediator complex non-fungal CDK2AP PF09806.4 CDI80782.1 - 0.19 11.9 0.0 0.19 11.9 0.0 8.8 4 3 2 6 6 6 0 Cyclin-dependent kinase 2-associated protein TFIIA PF03153.8 CDI80784.1 - 2.8 7.7 16.3 1 9.1 2.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit His_Phos_1 PF00300.17 CDI80785.1 - 0.00014 21.9 0.0 0.014 15.5 0.0 2.3 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF2489 PF10675.4 CDI80785.1 - 0.08 12.6 3.7 0.18 11.5 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) SR-25 PF10500.4 CDI80785.1 - 0.81 9.1 10.0 1.8 7.9 5.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Dehydrin PF00257.14 CDI80785.1 - 2.3 8.5 9.4 0.053 13.8 1.0 2.0 2 1 0 2 2 2 0 Dehydrin Ribosomal_60s PF00428.14 CDI80785.1 - 7.2 7.0 12.6 1.6e+02 2.7 8.0 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein TAXi_C PF14541.1 CDI80786.1 - 4.7e-18 65.2 0.0 6.5e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.18 CDI80786.1 - 0.00011 21.5 0.0 0.00019 20.7 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Radial_spoke_3 PF06098.6 CDI80787.1 - 6.1e-40 137.0 12.1 5.5e-37 127.3 5.0 2.1 1 1 0 2 2 2 2 Radial spoke protein 3 CAF-1_p150 PF11600.3 CDI80788.1 - 0.013 14.8 21.4 0.015 14.7 14.8 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Daxx PF03344.10 CDI80788.1 - 0.084 11.3 20.4 0.088 11.2 14.2 1.0 1 0 0 1 1 1 0 Daxx Family Herpes_DNAp_acc PF04929.7 CDI80788.1 - 0.096 11.6 15.5 0.11 11.4 10.7 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF1510 PF07423.6 CDI80788.1 - 0.11 11.8 24.4 0.12 11.7 16.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SR-25 PF10500.4 CDI80788.1 - 0.15 11.4 16.8 0.23 10.9 11.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.9 CDI80788.1 - 0.34 8.8 24.5 0.38 8.7 17.0 1.0 1 0 0 1 1 1 0 CDC45-like protein SprA-related PF12118.3 CDI80788.1 - 0.49 9.6 39.9 0.6 9.3 27.6 1.1 1 0 0 1 1 1 0 SprA-related family RR_TM4-6 PF06459.7 CDI80788.1 - 0.51 10.1 18.4 0.57 10.0 12.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.7 CDI80788.1 - 0.59 8.8 10.5 0.68 8.6 7.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) F-protein PF00469.15 CDI80788.1 - 0.64 9.3 17.4 0.78 9.0 12.0 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Zip PF02535.17 CDI80788.1 - 0.84 8.5 19.2 1 8.3 13.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter eIF-3_zeta PF05091.7 CDI80788.1 - 0.87 8.1 21.4 0.91 8.0 14.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Tim54 PF11711.3 CDI80788.1 - 0.88 8.0 11.1 1.1 7.7 7.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Spore_coat_CotO PF14153.1 CDI80788.1 - 0.88 8.9 28.8 1 8.7 20.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF4045 PF13254.1 CDI80788.1 - 0.93 8.7 19.6 1.1 8.5 13.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF4175 PF13779.1 CDI80788.1 - 1.2 6.7 48.6 1.3 6.6 33.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) VID27 PF08553.5 CDI80788.1 - 1.3 7.1 15.1 1.4 7.0 10.5 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein SID-1_RNA_chan PF13965.1 CDI80788.1 - 1.4 6.9 13.0 1.4 6.9 9.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Spore_YhcN_YlaJ PF09580.5 CDI80788.1 - 1.5 8.8 21.7 1.8 8.6 15.0 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PAT1 PF09770.4 CDI80788.1 - 1.6 6.9 40.5 1.7 6.7 28.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GAGA_bind PF06217.7 CDI80788.1 - 1.6 8.6 21.8 1.7 8.5 15.1 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.12 CDI80788.1 - 1.7 8.4 20.7 2.2 8.0 14.3 1.2 1 0 0 1 1 1 0 DDHD domain Raftlin PF15250.1 CDI80788.1 - 1.7 7.0 20.2 1.9 6.9 14.0 1.0 1 0 0 1 1 1 0 Raftlin Herpes_env PF01673.13 CDI80788.1 - 2.2 6.7 14.8 2.5 6.5 10.3 1.0 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein PPP4R2 PF09184.6 CDI80788.1 - 2.2 7.7 25.5 2.4 7.6 17.7 1.0 1 0 0 1 1 1 0 PPP4R2 TFIIA PF03153.8 CDI80788.1 - 2.2 8.0 32.7 2.5 7.9 22.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.1 CDI80788.1 - 2.3 8.3 15.5 2.9 8.0 10.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2126 PF09899.4 CDI80788.1 - 2.4 6.0 13.0 2.7 5.9 9.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) TRAP_alpha PF03896.11 CDI80788.1 - 2.5 7.0 10.1 3.3 6.6 7.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BTV_NS2 PF04514.7 CDI80788.1 - 2.5 6.8 19.4 2.7 6.7 13.4 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 IncA PF04156.9 CDI80788.1 - 2.6 7.6 27.2 2.9 7.4 18.9 1.1 1 0 0 1 1 1 0 IncA protein CMV_1a PF12467.3 CDI80788.1 - 2.6 8.3 13.3 2.9 8.2 9.2 1.1 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family DUF2201_N PF13203.1 CDI80788.1 - 2.7 7.0 22.4 3.1 6.8 15.5 1.0 1 0 0 1 1 1 0 Putative metallopeptidase domain Asp-B-Hydro_N PF05279.6 CDI80788.1 - 3 7.6 16.9 3.5 7.4 11.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DDRGK PF09756.4 CDI80788.1 - 3.1 7.1 28.0 4.1 6.7 19.4 1.2 1 0 0 1 1 1 0 DDRGK domain Parvo_coat PF00740.13 CDI80788.1 - 3.7 6.3 21.4 3.9 6.3 14.9 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Peptidase_S15 PF02129.13 CDI80788.1 - 3.9 6.8 13.9 4.6 6.5 9.6 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) AUX_IAA PF02309.11 CDI80788.1 - 4 7.1 16.1 5.5 6.6 11.2 1.3 1 0 0 1 1 1 0 AUX/IAA family DUF3260 PF11658.3 CDI80788.1 - 4.1 5.4 13.9 4.5 5.3 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Gag_spuma PF03276.9 CDI80788.1 - 4.3 5.5 30.1 5.2 5.2 20.9 1.2 1 0 0 1 1 1 0 Spumavirus gag protein FLO_LFY PF01698.11 CDI80788.1 - 4.5 6.0 20.3 5.2 5.8 14.1 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein SAPS PF04499.10 CDI80788.1 - 4.8 5.7 21.8 5.2 5.5 15.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Caldesmon PF02029.10 CDI80788.1 - 4.9 5.4 21.3 5.6 5.2 14.8 1.0 1 0 0 1 1 1 0 Caldesmon Suf PF05843.9 CDI80788.1 - 5 6.7 24.8 7.2 6.2 17.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.11 CDI80788.1 - 5.2 6.8 16.8 5.9 6.7 11.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Borrelia_P83 PF05262.6 CDI80788.1 - 5.4 5.1 22.9 5.7 5.0 15.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Rtf2 PF04641.7 CDI80788.1 - 5.7 6.0 20.4 6.7 5.8 14.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Ycf1 PF05758.7 CDI80788.1 - 6.2 4.3 21.5 6.4 4.3 14.9 1.0 1 0 0 1 1 1 0 Ycf1 FAM60A PF15396.1 CDI80788.1 - 6.3 6.4 18.5 7.3 6.2 12.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RNA_pol_Rpb1_5 PF04998.12 CDI80788.1 - 6.3 5.9 13.3 7.2 5.7 9.2 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Lin-8 PF03353.10 CDI80788.1 - 6.5 5.9 25.2 7.3 5.7 17.4 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Med15 PF09606.5 CDI80788.1 - 6.9 4.7 56.6 7.6 4.5 39.2 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DHHW PF14286.1 CDI80788.1 - 7.3 5.7 17.6 8.5 5.5 12.2 1.1 1 0 0 1 1 1 0 DHHW protein TT_ORF1 PF02956.9 CDI80788.1 - 7.6 4.8 17.6 8.5 4.6 12.2 1.0 1 0 0 1 1 1 0 TT viral orf 1 CobT PF06213.7 CDI80788.1 - 7.8 5.5 22.5 9.6 5.2 15.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MMR1 PF08505.5 CDI80788.1 - 8.1 6.4 27.3 9 6.2 18.9 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein YABBY PF04690.8 CDI80788.1 - 8.2 6.6 15.3 11 6.2 10.6 1.2 1 0 0 1 1 1 0 YABBY protein RE_TdeIII PF09520.5 CDI80788.1 - 8.4 5.6 16.8 10 5.2 11.7 1.2 1 0 0 1 1 1 0 Type II restriction endonuclease, TdeIII Collagen PF01391.13 CDI80789.1 - 6.2 6.4 10.4 3.6 7.1 2.1 3.2 3 0 0 3 3 3 0 Collagen triple helix repeat (20 copies) RBFA PF02033.13 CDI80790.1 - 8.3e-05 22.5 0.0 8.3e-05 22.5 0.0 2.3 3 0 0 3 3 3 1 Ribosome-binding factor A ABC2_membrane PF01061.19 CDI80790.1 - 0.14 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 ABC-2 type transporter 7tm_6 PF02949.15 CDI80790.1 - 1.5 7.5 4.0 2.9 6.6 2.8 1.4 1 0 0 1 1 1 0 7tm Odorant receptor DDHD PF02862.12 CDI80790.1 - 4.9 6.8 23.3 0.62 9.8 1.7 2.3 2 0 0 2 2 2 0 DDHD domain PAT1 PF09770.4 CDI80791.1 - 0.78 7.9 13.2 0.76 7.9 9.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Aminotran_5 PF00266.14 CDI80792.1 - 1.7e-72 244.2 8.0 7e-63 212.5 1.6 2.2 1 1 0 2 2 2 2 Aminotransferase class-V EPL1 PF10513.4 CDI80792.1 - 0.1 12.8 1.1 0.2 11.8 0.8 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like Activator_LAG-3 PF11498.3 CDI80792.1 - 0.11 11.2 17.7 0.027 13.2 8.6 2.1 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Macoilin PF09726.4 CDI80793.1 - 0.031 12.5 6.7 0.042 12.1 4.6 1.1 1 0 0 1 1 1 0 Transmembrane protein RabGAP-TBC PF00566.13 CDI80794.1 - 7e-22 77.9 0.0 1.2e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Gly-zipper_OmpA PF13436.1 CDI80794.1 - 0.13 11.9 11.6 0.27 10.9 8.0 1.5 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain CRISPR_Cse2 PF09485.5 CDI80794.1 - 1.3 9.0 6.9 1.9 8.5 1.1 3.4 4 0 0 4 4 4 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DcuA_DcuB PF03605.9 CDI80796.1 - 0.015 14.1 0.1 0.026 13.3 0.1 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter CTK3_C PF12350.3 CDI80796.1 - 0.037 14.0 0.2 0.037 14.0 0.1 2.6 2 1 1 3 3 2 0 CTD kinase subunit gamma CTK3 C-terminus Dicty_REP PF05086.7 CDI80796.1 - 0.044 11.5 3.3 0.057 11.1 2.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein BRF1 PF07741.8 CDI80796.1 - 0.076 13.2 17.2 0.3 11.3 4.0 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Med15 PF09606.5 CDI80796.1 - 0.083 11.0 59.3 0.11 10.7 41.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BTV_NS2 PF04514.7 CDI80796.1 - 0.22 10.3 10.1 0.3 9.9 1.4 2.1 2 0 0 2 2 2 0 Bluetongue virus non-structural protein NS2 Spore_coat_CotO PF14153.1 CDI80796.1 - 0.5 9.7 28.3 0.74 9.2 9.9 2.1 2 0 0 2 2 2 0 Spore coat protein CotO DUF1764 PF08576.5 CDI80796.1 - 0.5 11.1 19.6 2.2 9.1 2.2 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF3499 PF12005.3 CDI80796.1 - 1.6 8.9 11.1 0.28 11.3 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) Bud13 PF09736.4 CDI80796.1 - 1.7 8.8 25.1 2.2 8.5 7.8 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Rtf2 PF04641.7 CDI80796.1 - 1.8 7.7 15.6 3.3 6.8 5.1 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger ATAD4 PF15321.1 CDI80796.1 - 2.2 9.3 15.8 4.3 8.4 2.5 2.4 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 CDC45 PF02724.9 CDI80796.1 - 2.3 6.1 14.4 1.7 6.5 4.2 2.0 2 0 0 2 2 2 0 CDC45-like protein Afi1 PF07792.7 CDI80796.1 - 2.6 8.0 17.4 2.3 8.2 4.1 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FimP PF09766.4 CDI80796.1 - 2.7 6.9 38.5 0.36 9.8 10.3 2.1 2 0 0 2 2 2 0 Fms-interacting protein DUF853 PF05872.7 CDI80796.1 - 2.7 6.2 20.2 0.079 11.2 5.5 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Herpes_DNAp_acc PF04929.7 CDI80796.1 - 3.2 6.6 11.4 8.9 5.1 7.9 1.6 1 1 0 1 1 1 0 Herpes DNA replication accessory factor G-7-MTase PF12803.2 CDI80796.1 - 3.7 6.6 10.0 7 5.6 0.4 2.1 2 0 0 2 2 2 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) DUF913 PF06025.7 CDI80796.1 - 3.8 6.1 13.5 0.14 10.8 2.3 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PH_4 PF15404.1 CDI80796.1 - 4.5 6.7 13.9 1.3 8.5 1.5 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain FAM176 PF14851.1 CDI80796.1 - 4.8 6.8 13.2 2.2 7.9 3.1 2.1 2 0 0 2 2 2 0 FAM176 family DUF775 PF05603.7 CDI80796.1 - 5.2 6.5 20.1 3 7.3 3.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) SprA-related PF12118.3 CDI80796.1 - 5.6 6.2 43.6 0.37 10.0 11.9 2.1 2 0 0 2 2 2 0 SprA-related family RP-C_C PF11800.3 CDI80796.1 - 5.6 6.6 15.1 1.6 8.4 2.9 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF1510 PF07423.6 CDI80796.1 - 5.8 6.2 21.9 3.6 6.9 6.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Pex14_N PF04695.8 CDI80796.1 - 6.2 6.8 32.1 2.4 8.2 6.7 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hamartin PF04388.7 CDI80796.1 - 6.3 5.3 14.9 7.8 5.0 10.3 1.1 1 0 0 1 1 1 0 Hamartin protein HlyD_2 PF12700.2 CDI80796.1 - 6.4 5.8 21.2 1.3 8.1 6.9 2.0 2 0 0 2 2 2 0 HlyD family secretion protein Packaging_FI PF14000.1 CDI80796.1 - 7.2 6.8 15.7 0.42 10.7 3.8 2.1 2 0 0 2 2 2 0 DNA packaging protein FI FCP1_C PF09309.5 CDI80796.1 - 7.4 5.7 23.8 1.5 8.0 5.4 2.3 2 0 0 2 2 2 0 FCP1, C-terminal AIF_C PF14721.1 CDI80796.1 - 8 6.7 17.0 6.2 7.0 4.2 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Peroxin-13_N PF04088.8 CDI80796.1 - 8.7 6.2 14.2 2.3 8.1 3.2 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region TFIIA PF03153.8 CDI80796.1 - 9 6.0 37.8 13 5.5 26.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dala_Dala_lig_N PF01820.16 CDI80796.1 - 10 6.4 11.4 10 6.4 2.0 2.2 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus SICA_C PF12879.2 CDI80797.1 - 0.03 14.1 1.3 0.061 13.1 0.3 2.0 1 1 0 1 1 1 0 SICA C-terminal inner membrane domain RRM_1 PF00076.17 CDI80798.1 - 4.6e-05 22.9 0.0 7.8e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_C42 PF05533.7 CDI80798.1 - 0.16 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 CENP-T PF15511.1 CDI80798.1 - 0.33 10.1 14.1 0.39 9.9 9.7 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Med3 PF11593.3 CDI80798.1 - 7.3 5.7 14.3 8.5 5.5 9.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF179 PF02622.10 CDI80799.1 - 3.9e-08 33.0 0.2 0.00049 19.7 0.1 2.7 2 1 0 2 2 2 2 Uncharacterized ACR, COG1678 FMO-like PF00743.14 CDI80799.1 - 0.015 13.5 0.0 0.023 12.9 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like SprA-related PF12118.3 CDI80799.1 - 0.23 10.7 0.0 0.23 10.7 0.0 6.3 2 1 3 5 5 5 0 SprA-related family SR-25 PF10500.4 CDI80801.1 - 3.3e-05 23.4 13.3 3.3e-05 23.4 9.2 4.3 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein UPF0016 PF01169.14 CDI80806.1 - 1.7e-24 85.7 29.6 2.1e-17 63.0 4.6 2.9 3 1 0 3 3 2 2 Uncharacterized protein family UPF0016 Med15 PF09606.5 CDI80806.1 - 0.017 13.3 55.0 0.025 12.8 38.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SAPS PF04499.10 CDI80806.1 - 0.02 13.5 13.3 0.032 12.8 9.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein YjgP_YjgQ PF03739.9 CDI80806.1 - 0.02 13.6 0.2 0.036 12.8 0.2 1.4 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DUF2076 PF09849.4 CDI80806.1 - 0.056 13.4 0.3 0.056 13.4 0.2 4.2 3 1 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2076) CAF-1_p150 PF11600.3 CDI80806.1 - 0.072 12.4 49.0 0.021 14.2 28.0 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Raftlin PF15250.1 CDI80806.1 - 0.43 9.0 19.4 0.97 7.8 13.4 1.6 1 0 0 1 1 1 0 Raftlin LMBR1 PF04791.11 CDI80806.1 - 0.67 8.4 7.2 0.036 12.6 1.4 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein GAGA_bind PF06217.7 CDI80806.1 - 1.7 8.5 25.8 2.8 7.8 17.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Parvo_coat PF00740.13 CDI80806.1 - 1.8 7.4 24.0 2.7 6.8 16.6 1.2 1 0 0 1 1 1 0 Parvovirus coat protein VP2 CDC45 PF02724.9 CDI80806.1 - 2 6.3 25.7 3.1 5.7 17.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Dicty_REP PF05086.7 CDI80806.1 - 2.6 5.7 13.0 3.3 5.3 9.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Cellulose_synt PF03552.9 CDI80806.1 - 3 6.0 8.4 4.3 5.5 5.8 1.1 1 0 0 1 1 1 0 Cellulose synthase Sec62 PF03839.11 CDI80806.1 - 3.2 7.0 22.6 5.9 6.2 15.7 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Daxx PF03344.10 CDI80806.1 - 4.6 5.5 32.0 8.6 4.7 22.2 1.3 1 0 0 1 1 1 0 Daxx Family TFIIA PF03153.8 CDI80806.1 - 6.6 6.5 42.7 1.1 9.1 27.0 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.5 CDI80806.1 - 7.1 4.9 19.4 12 4.2 13.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PLRV_ORF5 PF01690.12 CDI80806.1 - 9.6 5.2 26.6 16 4.4 18.5 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Hid1 PF12722.2 CDI80806.1 - 9.8 3.7 27.1 17 2.8 18.8 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GPI2 PF06432.6 CDI80808.1 - 1.1e-29 103.6 4.1 1.2e-29 103.5 2.9 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase COPI_assoc PF08507.5 CDI80808.1 - 0.074 12.7 0.4 0.096 12.3 0.3 1.2 1 0 0 1 1 1 0 COPI associated protein PC_rep PF01851.17 CDI80809.1 - 1.7e-07 31.0 10.1 0.01 16.0 0.1 5.0 4 0 0 4 4 4 3 Proteasome/cyclosome repeat Sporozoite_P67 PF05642.6 CDI80809.1 - 0.0025 15.7 6.5 0.077 10.8 0.0 3.4 3 1 0 3 3 3 1 Sporozoite P67 surface antigen PepX_C PF08530.5 CDI80809.1 - 0.21 11.4 2.7 0.41 10.4 1.9 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Miff PF05644.6 CDI80809.1 - 1.7 8.2 6.1 0.81 9.2 1.4 2.0 2 0 0 2 2 2 0 Mitochondrial and peroxisomal fission factor Mff Tmemb_cc2 PF10267.4 CDI80809.1 - 2.1 6.8 15.0 0.71 8.4 4.3 2.5 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein CWC25 PF12542.3 CDI80811.1 - 0.31 11.5 0.1 0.31 11.5 0.1 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing factor APC_CDC26 PF10471.4 CDI80811.1 - 2.7 8.7 15.5 1 10.1 0.9 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 DUF1528 PF07515.6 CDI80811.1 - 3 7.9 6.0 57 3.8 4.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1528) MIF4G_like_2 PF09090.6 CDI80812.1 - 9.1e-11 41.4 0.2 4.1e-10 39.3 0.0 2.0 2 1 0 2 2 2 1 MIF4G like MIF4G PF02854.14 CDI80812.1 - 3.4e-07 29.8 0.6 7.6e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 MIF4G domain Ribosomal_60s PF00428.14 CDI80815.1 - 0.015 15.7 3.5 0.015 15.7 2.4 5.9 3 1 2 5 5 5 0 60s Acidic ribosomal protein CD20 PF04103.10 CDI80815.1 - 0.087 12.7 0.1 0.087 12.7 0.1 2.9 4 0 0 4 4 4 0 CD20-like family zf-DHHC PF01529.15 CDI80815.1 - 0.14 11.5 2.3 0.5 9.7 0.2 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase FHIPEP PF00771.15 CDI80815.1 - 0.24 9.6 7.7 0.024 13.0 1.0 2.1 2 0 0 2 2 2 0 FHIPEP family Ycf1 PF05758.7 CDI80815.1 - 3.4 5.2 19.6 0.076 10.7 4.9 2.1 2 0 0 2 2 2 0 Ycf1 Hid1 PF12722.2 CDI80815.1 - 5.8 4.4 30.7 0.0038 15.0 0.9 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Metallophos PF00149.23 CDI80816.1 - 0.043 13.2 0.0 0.083 12.2 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase DUF3043 PF11241.3 CDI80817.1 - 0.087 12.4 0.3 0.1 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4175 PF13779.1 CDI80819.1 - 0.0021 15.8 36.5 0.0021 15.8 25.3 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4175) Dehydrin PF00257.14 CDI80819.1 - 0.069 13.4 0.2 0.069 13.4 0.1 5.8 5 2 0 5 5 5 0 Dehydrin CHORD PF04968.7 CDI80820.1 - 3e-09 36.9 0.4 3e-09 36.9 0.2 2.1 3 0 0 3 3 3 1 CHORD Ycf1 PF05758.7 CDI80820.1 - 0.67 7.5 13.8 1.3 6.6 9.6 1.4 1 0 0 1 1 1 0 Ycf1 DUF2217 PF10265.4 CDI80820.1 - 4.4 5.9 25.2 8.3 5.0 17.5 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) TMEM154 PF15102.1 CDI80821.1 - 0.0049 16.5 1.2 0.0049 16.5 0.8 1.7 2 0 0 2 2 2 1 TMEM154 protein family Lipoprotein_2 PF00921.12 CDI80821.1 - 3.9 7.4 11.4 0.28 11.1 2.5 2.1 2 0 0 2 2 2 0 Borrelia lipoprotein 2-oxoacid_dh PF00198.18 CDI80822.1 - 5.4e-15 55.3 0.6 8.4e-15 54.6 0.4 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) CD20 PF04103.10 CDI80824.1 - 0.15 12.0 3.4 1.1 9.1 0.1 3.1 4 0 0 4 4 4 0 CD20-like family Nop PF01798.13 CDI80827.1 - 3.9e-52 175.5 3.7 1.2e-51 173.9 2.1 2.0 2 0 0 2 2 2 1 Putative snoRNA binding domain NOSIC PF08060.8 CDI80827.1 - 1.3e-23 82.5 0.1 3.3e-23 81.2 0.0 1.7 2 0 0 2 2 2 1 NOSIC (NUC001) domain Sugarporin_N PF11471.3 CDI80827.1 - 0.31 10.6 0.0 0.31 10.6 0.0 3.1 4 0 0 4 4 4 0 Maltoporin periplasmic N-terminal extension DUF3138 PF11336.3 CDI80827.1 - 0.66 8.0 4.2 1 7.4 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TPR_11 PF13414.1 CDI80828.1 - 4.2e-07 29.5 14.9 0.0022 17.6 0.5 3.8 3 0 0 3 3 3 2 TPR repeat TPR_9 PF13371.1 CDI80828.1 - 0.00044 20.0 17.1 0.011 15.5 1.6 4.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI80828.1 - 0.0023 17.6 10.2 1.3 9.0 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF530 PF04409.7 CDI80828.1 - 0.0028 15.8 0.2 0.0044 15.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF530) Arm PF00514.18 CDI80828.1 - 1.1 9.1 20.3 1.1 9.2 0.5 6.7 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat TPR_17 PF13431.1 CDI80828.1 - 3.4 8.0 9.1 0.21 11.8 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-CCCH PF00642.19 CDI80829.1 - 0.00063 19.3 0.8 0.00063 19.3 0.5 3.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_10 PF12846.2 CDI80831.1 - 0.055 12.8 2.0 0.067 12.6 1.4 1.1 1 0 0 1 1 1 0 AAA-like domain Reo_sigmaC PF04582.7 CDI80831.1 - 0.79 8.8 4.3 0.94 8.5 3.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein SprA-related PF12118.3 CDI80831.1 - 1.7 7.9 16.1 2.3 7.4 11.2 1.2 1 0 0 1 1 1 0 SprA-related family APG6 PF04111.7 CDI80831.1 - 2.6 7.0 22.4 3.6 6.5 15.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Birna_RdRp PF04197.7 CDI80831.1 - 3.1 5.6 7.2 3.4 5.5 5.0 1.2 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) CorA PF01544.13 CDI80831.1 - 3.2 6.6 10.0 0.6 9.0 4.3 1.6 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein ADIP PF11559.3 CDI80831.1 - 4.1 7.2 28.2 0.23 11.3 13.1 2.2 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Asp-B-Hydro_N PF05279.6 CDI80831.1 - 5.9 6.6 8.8 9.4 6.0 6.1 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PP2C_C PF07830.8 CDI80831.1 - 6.2 7.0 6.7 3.4 7.8 0.7 2.4 1 1 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Spc97_Spc98 PF04130.8 CDI80832.1 - 2.2e-16 59.2 1.0 3.2e-16 58.7 0.7 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family Sporozoite_P67 PF05642.6 CDI80834.1 - 0.45 8.3 12.0 0.48 8.2 8.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF572 PF04502.8 CDI80834.1 - 1.2 8.3 18.0 1.6 7.9 12.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Band_3_cyto PF07565.8 CDI80834.1 - 2.3 7.6 15.1 3.2 7.2 10.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DNA_pol_viral_N PF00242.12 CDI80834.1 - 5.2 5.9 22.4 5.6 5.8 15.5 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain RR_TM4-6 PF06459.7 CDI80834.1 - 5.8 6.7 9.2 7.8 6.2 6.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2217 PF10265.4 CDI80834.1 - 8.7 4.9 14.8 10 4.7 10.3 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF1308 PF07000.6 CDI80835.1 - 0.0092 14.6 0.3 0.0092 14.6 0.2 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1308) SAPS PF04499.10 CDI80835.1 - 0.051 12.2 7.7 0.064 11.8 5.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDK2AP PF09806.4 CDI80835.1 - 0.089 13.0 15.3 0.047 13.9 4.5 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Lipoprotein_X PF03305.8 CDI80835.1 - 0.17 11.2 9.5 2.7 7.3 3.8 2.1 2 0 0 2 2 2 0 Mycoplasma MG185/MG260 protein Presenilin PF01080.12 CDI80835.1 - 0.24 10.2 4.4 0.46 9.2 3.1 1.3 1 1 0 1 1 1 0 Presenilin DUF1669 PF07894.7 CDI80835.1 - 0.26 10.4 15.0 3.3 6.8 10.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1669) DUF3464 PF11947.3 CDI80835.1 - 0.4 10.1 10.0 1.1 8.6 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3464) Baculo_PP31 PF05311.6 CDI80835.1 - 0.5 9.5 15.3 0.11 11.7 2.9 2.0 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Rtf2 PF04641.7 CDI80835.1 - 0.57 9.3 13.6 5.6 6.0 6.3 2.0 2 0 0 2 2 2 0 Rtf2 RING-finger eIF-3_zeta PF05091.7 CDI80835.1 - 1.2 7.6 20.4 1.3 7.5 7.5 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TraV PF09676.5 CDI80835.1 - 1.3 9.7 11.4 7.3 7.3 3.5 2.2 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) LMBR1 PF04791.11 CDI80835.1 - 1.5 7.3 3.2 3.7 6.0 2.3 1.6 1 1 0 1 1 1 0 LMBR1-like membrane protein RNR_inhib PF08591.5 CDI80835.1 - 4.1 8.3 10.6 30 5.6 0.1 2.2 2 0 0 2 2 2 0 Ribonucleotide reductase inhibitor DUF1510 PF07423.6 CDI80835.1 - 7.3 5.8 22.8 1.6 8.0 8.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Na_trans_assoc PF06512.8 CDI80835.1 - 8.6 6.2 12.0 7.8 6.3 0.5 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated DUF3361 PF11841.3 CDI80839.1 - 0.087 12.5 0.4 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) TPR_16 PF13432.1 CDI80839.1 - 0.19 12.4 0.9 7 7.4 0.1 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat GCC2_GCC3 PF07699.8 CDI80840.1 - 6.3e-05 22.4 7.8 6.3e-05 22.4 5.4 4.1 2 1 0 2 2 2 1 GCC2 and GCC3 NCD3G PF07562.9 CDI80840.1 - 0.0021 17.7 3.6 0.0021 17.7 2.5 4.0 1 1 3 4 4 4 1 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.13 CDI80840.1 - 0.019 14.9 19.2 0.15 12.1 0.9 3.4 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region GCC2_GCC3 PF07699.8 CDI80841.1 - 6.3e-09 35.2 39.8 0.00028 20.3 1.8 6.5 4 1 2 6 6 6 5 GCC2 and GCC3 F5_F8_type_C PF00754.20 CDI80841.1 - 0.00041 20.1 0.0 0.0007 19.4 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain stn_TNFRSF12A PF12191.3 CDI80841.1 - 0.098 12.7 0.7 0.3 11.1 0.5 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF3373 PF11853.3 CDI80843.1 - 0.0029 16.2 5.3 0.0027 16.3 3.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3373) DUF3300 PF11737.3 CDI80843.1 - 0.023 13.9 4.0 0.026 13.8 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3300) Spc7 PF08317.6 CDI80843.1 - 0.037 12.7 8.6 0.043 12.4 6.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein CALCOCO1 PF07888.6 CDI80843.1 - 0.064 11.5 7.6 0.063 11.5 5.3 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like V-ATPase_C PF03223.10 CDI80843.1 - 0.073 11.9 4.3 0.11 11.4 3.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit C IncA PF04156.9 CDI80843.1 - 0.077 12.5 17.1 0.1 12.1 11.9 1.2 1 0 0 1 1 1 0 IncA protein COG6 PF06419.6 CDI80843.1 - 0.08 11.0 10.5 0.098 10.7 7.3 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Sas10_Utp3 PF04000.10 CDI80843.1 - 0.093 12.9 2.1 2 8.6 1.6 2.2 2 0 0 2 2 2 0 Sas10/Utp3/C1D family Med4 PF10018.4 CDI80843.1 - 0.094 12.1 10.2 0.14 11.5 7.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Allexi_40kDa PF05549.6 CDI80843.1 - 0.098 11.9 3.9 0.11 11.7 2.7 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein L31 PF09784.4 CDI80843.1 - 0.14 12.2 5.9 0.22 11.6 4.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 XPG_I_2 PF12813.2 CDI80843.1 - 0.14 11.5 2.5 0.17 11.3 1.7 1.2 1 0 0 1 1 1 0 XPG domain containing V_ATPase_I PF01496.14 CDI80843.1 - 0.16 9.7 4.4 0.18 9.6 3.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF641 PF04859.7 CDI80843.1 - 0.16 11.6 10.1 0.32 10.7 7.0 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) AAA_13 PF13166.1 CDI80843.1 - 0.18 10.2 5.5 0.18 10.2 3.8 1.1 1 0 0 1 1 1 0 AAA domain Mod_r PF07200.8 CDI80843.1 - 0.18 11.7 14.4 0.3 10.9 10.0 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein VGLL4 PF15245.1 CDI80843.1 - 0.25 11.1 6.3 0.3 10.8 4.4 1.1 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 EIF4E-T PF10477.4 CDI80843.1 - 0.33 9.7 5.5 0.36 9.5 3.8 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4201 PF13870.1 CDI80843.1 - 0.33 10.3 13.8 0.58 9.5 9.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF2092 PF09865.4 CDI80843.1 - 0.35 9.8 5.1 0.42 9.6 3.5 1.2 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2092) Calici_MSP PF05752.6 CDI80843.1 - 0.39 10.3 12.1 0.54 9.8 8.4 1.3 1 0 0 1 1 1 0 Calicivirus minor structural protein TPR_MLP1_2 PF07926.7 CDI80843.1 - 0.47 10.1 17.2 1.7 8.3 11.9 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein BRICHOS PF04089.9 CDI80843.1 - 0.53 10.1 2.8 0.9 9.4 2.0 1.3 1 0 0 1 1 1 0 BRICHOS domain Muted PF14942.1 CDI80843.1 - 0.7 9.7 8.6 1 9.2 6.0 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein FliP PF00813.15 CDI80843.1 - 0.73 9.5 2.6 0.88 9.2 1.8 1.2 1 0 0 1 1 1 0 FliP family DUF4164 PF13747.1 CDI80843.1 - 0.84 9.8 8.9 1.6 8.9 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) APG6 PF04111.7 CDI80843.1 - 0.85 8.6 12.9 1.2 8.1 9.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Atg14 PF10186.4 CDI80843.1 - 0.9 8.4 11.2 1.2 8.0 7.8 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Mgr1 PF08602.5 CDI80843.1 - 0.94 8.4 3.6 1.2 8.0 2.5 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit FHIPEP PF00771.15 CDI80843.1 - 0.95 7.7 6.8 1.1 7.4 4.7 1.1 1 0 0 1 1 1 0 FHIPEP family KTI12 PF08433.5 CDI80843.1 - 1 8.5 7.2 1.2 8.2 5.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Spc24 PF08286.6 CDI80843.1 - 1.3 8.7 9.7 2 8.1 6.7 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 FlxA PF14282.1 CDI80843.1 - 1.4 8.8 28.1 2.2 8.3 19.5 1.3 1 0 0 1 1 1 0 FlxA-like protein HlyD_2 PF12700.2 CDI80843.1 - 1.6 7.8 5.3 1.6 7.8 3.7 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Macoilin PF09726.4 CDI80843.1 - 1.7 6.8 11.2 1.6 6.9 7.8 1.1 1 0 0 1 1 1 0 Transmembrane protein Mnd1 PF03962.10 CDI80843.1 - 1.7 8.2 11.9 2.7 7.6 8.3 1.4 1 0 0 1 1 1 0 Mnd1 family DUF4407 PF14362.1 CDI80843.1 - 2.1 7.2 14.0 3 6.7 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IFT57 PF10498.4 CDI80843.1 - 2.5 6.7 13.6 3.1 6.4 9.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 ADIP PF11559.3 CDI80843.1 - 3.3 7.6 18.7 4.9 7.0 13.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Adeno_PIX PF03955.9 CDI80843.1 - 3.4 8.2 7.1 4.2 7.9 4.3 1.6 1 1 0 1 1 1 0 Adenovirus hexon-associated protein (IX) 5_nucleotid PF05761.9 CDI80843.1 - 4 5.8 7.8 4.9 5.5 5.4 1.1 1 0 0 1 1 1 0 5' nucleotidase family Med15 PF09606.5 CDI80843.1 - 4.1 5.4 23.2 3.9 5.5 16.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EAP30 PF04157.11 CDI80843.1 - 4.3 6.4 12.4 5.5 6.0 8.6 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family DUF342 PF03961.8 CDI80843.1 - 5.4 5.3 6.6 7 4.9 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3450 PF11932.3 CDI80843.1 - 6.7 5.8 20.9 2.4 7.3 12.9 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF3450) FUSC PF04632.7 CDI80843.1 - 9.5 4.5 11.4 10 4.4 7.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Macoilin PF09726.4 CDI80845.1 - 0.019 13.2 8.4 0.026 12.8 5.8 1.3 1 0 0 1 1 1 0 Transmembrane protein NVEALA PF14055.1 CDI80845.1 - 0.062 13.0 0.1 0.16 11.6 0.1 1.7 1 0 0 1 1 1 0 NVEALA protein DUF3801 PF12687.2 CDI80845.1 - 0.3 10.6 7.3 0.53 9.8 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Band_3_cyto PF07565.8 CDI80845.1 - 0.95 8.9 5.0 1.4 8.3 3.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Raftlin PF15250.1 CDI80845.1 - 0.98 7.8 8.1 1.3 7.4 5.6 1.1 1 0 0 1 1 1 0 Raftlin DDHD PF02862.12 CDI80845.1 - 1.2 8.8 8.6 1.6 8.4 6.0 1.3 1 0 0 1 1 1 0 DDHD domain Pal1 PF08316.6 CDI80845.1 - 1.6 9.2 4.0 43 4.5 2.8 2.4 1 1 1 2 2 2 0 Pal1 cell morphology protein DUF4614 PF15391.1 CDI80845.1 - 3.8 7.2 14.5 6.2 6.5 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Period_C PF12114.3 CDI80845.1 - 4.6 6.8 22.5 0.69 9.4 12.9 1.6 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Acyl-thio_N PF12590.3 CDI80845.1 - 4.8 7.6 9.0 4.6 7.7 5.3 1.6 2 0 0 2 2 2 0 Acyl-ATP thioesterase THRAP3_BCLAF1 PF15440.1 CDI80845.1 - 5.3 5.5 19.8 7.1 5.1 13.7 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family CAF-1_p150 PF11600.3 CDI80845.1 - 5.5 6.3 16.2 0.98 8.7 8.9 1.4 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal His_Phos_1 PF00300.17 CDI80846.1 - 1.3e-06 28.6 10.6 5.7e-06 26.5 7.4 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) FimP PF09766.4 CDI80846.1 - 0.0018 17.4 10.3 0.0021 17.2 7.2 1.1 1 0 0 1 1 1 1 Fms-interacting protein IncA PF04156.9 CDI80846.1 - 0.019 14.5 29.1 0.086 12.4 4.8 2.3 2 0 0 2 2 2 0 IncA protein Suf PF05843.9 CDI80846.1 - 0.027 14.1 11.8 0.038 13.7 8.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.7 CDI80846.1 - 0.44 10.3 9.5 0.57 10.0 6.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2910 PF11139.3 CDI80846.1 - 2.8 7.0 21.6 4.5 6.3 13.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2910) Serinc PF03348.10 CDI80846.1 - 6.4 5.3 9.4 10 4.7 6.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Trypan_glycop_C PF10659.4 CDI80846.1 - 9.2 6.6 13.4 23 5.3 9.3 1.7 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain Pkinase PF00069.20 CDI80847.1 - 1.8e-43 148.5 0.0 1.8e-43 148.5 0.0 4.6 3 2 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80847.1 - 1.6e-19 70.0 0.0 1.6e-19 70.0 0.0 3.3 4 1 0 4 4 4 1 Protein tyrosine kinase zf-CCCH PF00642.19 CDI80848.1 - 5.1e-10 38.7 29.5 2.2e-05 24.0 3.9 3.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3H1 PF10650.4 CDI80848.1 - 0.54 9.7 4.3 0.88 9.1 0.4 2.7 2 0 0 2 2 2 0 Putative zinc-finger domain SR-25 PF10500.4 CDI80849.1 - 0.007 15.8 7.3 0.0078 15.7 5.1 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein NAGidase PF07555.8 CDI80850.1 - 0.0058 15.5 0.0 0.0067 15.3 0.0 1.0 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase DUF1183 PF06682.7 CDI80850.1 - 0.1 12.1 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Phage_Mu_F PF04233.9 CDI80852.1 - 0.015 15.7 1.0 0.015 15.7 0.7 3.9 4 1 1 5 5 5 0 Phage Mu protein F like protein DnaJ-X PF14308.1 CDI80852.1 - 2.3 7.4 22.5 0.28 10.4 2.5 2.6 2 0 0 2 2 2 0 X-domain of DnaJ-containing Serinc PF03348.10 CDI80852.1 - 2.5 6.7 27.6 0.034 12.8 2.1 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF4496 PF14908.1 CDI80852.1 - 7.8 6.3 17.5 3.4 7.5 2.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4496) TGS PF02824.16 CDI80853.1 - 7.5e-23 80.1 0.0 1.3e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 TGS domain Spore_coat_CotO PF14153.1 CDI80854.1 - 0.00057 19.3 11.5 0.00057 19.3 8.0 5.3 4 1 0 4 4 4 1 Spore coat protein CotO ATG22 PF11700.3 CDI80854.1 - 3.4 6.0 8.4 0.13 10.7 0.4 2.6 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like Ycf1 PF05758.7 CDI80854.1 - 4.3 4.9 30.6 0.0052 14.5 3.3 3.2 3 0 0 3 3 3 0 Ycf1 Pkinase PF00069.20 CDI80856.1 - 8.4e-11 41.4 0.3 5.6e-08 32.2 0.0 4.5 3 2 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80856.1 - 0.0093 15.0 0.0 0.27 10.2 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase zf-DHHC PF01529.15 CDI80856.1 - 0.25 10.6 5.5 1.1 8.5 0.1 3.1 3 0 0 3 3 3 0 DHHC palmitoyltransferase DUF1675 PF07897.6 CDI80863.1 - 0.31 10.8 21.0 0.4 10.5 14.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DNA_pol_viral_N PF00242.12 CDI80863.1 - 0.42 9.5 16.2 0.54 9.2 11.2 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Hid1 PF12722.2 CDI80863.1 - 0.95 7.0 13.6 1.1 6.7 9.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.5 CDI80863.1 - 1.8 7.5 18.0 2.3 7.2 12.5 1.0 1 0 0 1 1 1 0 BUD22 Telomerase_RBD PF12009.3 CDI80864.1 - 1.9e-20 73.1 11.7 3.5e-13 49.6 3.3 5.5 6 1 1 7 7 7 2 Telomerase ribonucleoprotein complex - RNA binding domain PAT1 PF09770.4 CDI80864.1 - 7.4e-05 21.2 44.3 7.4e-05 21.2 30.7 5.7 4 1 1 5 5 5 2 Topoisomerase II-associated protein PAT1 OmpH PF03938.9 CDI80864.1 - 0.095 12.6 0.0 0.095 12.6 0.0 9.1 7 4 1 8 8 8 0 Outer membrane protein (OmpH-like) Spt5-NGN PF03439.8 CDI80866.1 - 0.096 12.4 0.0 13 5.6 0.0 2.2 1 1 1 2 2 2 0 Early transcription elongation factor of RNA pol II, NGN section Polysacc_synt_3 PF13440.1 CDI80868.1 - 0.037 13.4 2.6 0.068 12.6 1.8 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Vps39_2 PF10367.4 CDI80870.1 - 9.1e-19 67.6 0.0 9.1e-19 67.6 0.0 3.6 3 1 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 CDI80870.1 - 9.3e-06 25.2 0.6 9.3e-06 25.2 0.4 3.1 3 0 0 3 3 3 1 Region in Clathrin and VPS Suf PF05843.9 CDI80870.1 - 0.018 14.7 18.2 0.28 10.8 1.1 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI80870.1 - 0.12 10.6 40.9 0.072 11.3 4.2 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 7tm_1 PF00001.16 CDI80870.1 - 2.1 7.4 4.0 3.3 6.7 0.5 2.4 3 0 0 3 3 3 0 7 transmembrane receptor (rhodopsin family) DEAD_2 PF06733.10 CDI80871.1 - 8.6e-26 90.3 2.2 1.8e-21 76.3 0.1 3.0 2 1 0 2 2 2 2 DEAD_2 ResIII PF04851.10 CDI80871.1 - 0.00015 21.6 3.9 0.00015 21.6 2.7 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 CDI80871.1 - 0.0051 16.2 0.1 0.017 14.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 CDI80871.1 - 0.0066 15.6 0.4 0.082 12.1 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein SR-25 PF10500.4 CDI80871.1 - 0.0067 15.9 3.6 0.0067 15.9 2.5 3.2 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Suc_Fer-like PF06999.7 CDI80871.1 - 0.015 15.3 1.1 0.015 15.3 0.8 2.6 2 1 0 2 2 2 0 Sucrase/ferredoxin-like Ras PF00071.17 CDI80873.1 - 5.7e-40 136.3 0.6 2.9e-38 130.8 0.2 2.6 2 1 0 2 2 2 1 Ras family Miro PF08477.8 CDI80873.1 - 8.9e-19 68.1 0.9 4.1e-18 66.0 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CDI80873.1 - 2.7e-11 42.9 0.0 4.5e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDI80873.1 - 1.1e-05 24.6 0.1 1.1e-05 24.6 0.0 2.9 2 1 1 3 3 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDI80873.1 - 0.00036 20.0 2.6 0.0011 18.4 1.6 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI80873.1 - 0.0042 17.0 0.0 0.011 15.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase IstB_IS21 PF01695.12 CDI80873.1 - 0.042 13.2 0.0 0.11 11.8 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Hpr_kinase_C PF07475.7 CDI80873.1 - 0.23 10.7 0.0 0.23 10.7 0.0 1.7 2 0 0 2 2 1 0 HPr Serine kinase C-terminal domain AAA_24 PF13479.1 CDI80873.1 - 0.25 10.8 0.0 0.25 10.8 0.0 2.6 3 0 0 3 3 2 0 AAA domain Neur_chan_memb PF02932.11 CDI80873.1 - 3.9 7.2 20.9 3.8 7.3 3.9 2.3 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RAP1 PF07218.6 CDI80873.1 - 5.7 4.9 22.5 9.2 4.2 15.6 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3306 PF11748.3 CDI80873.1 - 8.9 7.0 21.6 1.6 9.4 1.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3306) DUF4407 PF14362.1 CDI80873.1 - 9.1 5.1 19.6 0.74 8.7 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Med15 PF09606.5 CDI80874.1 - 0.0031 15.7 11.6 0.0031 15.7 8.0 2.1 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Memo PF01875.12 CDI80875.1 - 1.7e-51 174.7 0.0 2.9e-51 173.9 0.0 1.3 1 1 0 1 1 1 1 Memo-like protein BAF1_ABF1 PF04684.8 CDI80876.1 - 0.0012 17.8 11.0 0.0012 17.8 7.7 3.0 3 1 0 3 3 3 2 BAF1 / ABF1 chromatin reorganising factor DUF4544 PF15077.1 CDI80876.1 - 0.091 12.2 0.1 0.091 12.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4544) DUF3429 PF11911.3 CDI80878.1 - 6.3e-06 26.2 4.0 1e-05 25.5 2.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Med15 PF09606.5 CDI80878.1 - 0.0097 14.1 15.2 0.013 13.7 10.5 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2126 PF09899.4 CDI80878.1 - 0.025 12.6 0.2 0.033 12.2 0.2 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Activator_LAG-3 PF11498.3 CDI80878.1 - 0.049 12.3 17.1 0.075 11.7 11.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Plasmodium_Vir PF05795.6 CDI80878.1 - 0.063 12.4 2.4 0.082 12.1 1.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RAB3GAP2_N PF14655.1 CDI80878.1 - 0.069 12.1 5.0 0.11 11.4 3.5 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF912 PF06024.7 CDI80878.1 - 0.22 11.5 2.9 6.7 6.8 1.8 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MAP65_ASE1 PF03999.7 CDI80878.1 - 0.31 9.5 6.5 0.46 9.0 4.5 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF4175 PF13779.1 CDI80878.1 - 0.67 7.5 13.7 0.96 7.0 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4407 PF14362.1 CDI80878.1 - 2.1 7.2 6.3 3.1 6.6 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FimP PF09766.4 CDI80878.1 - 2.6 7.0 11.0 5.4 5.9 7.6 1.4 1 0 0 1 1 1 0 Fms-interacting protein CDK2AP PF09806.4 CDI80878.1 - 4.1 7.5 19.8 0.057 13.6 6.2 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein BAF1_ABF1 PF04684.8 CDI80879.1 - 0.0028 16.6 8.5 0.0028 16.6 5.9 6.9 6 1 1 7 7 7 1 BAF1 / ABF1 chromatin reorganising factor DUF3959 PF13105.1 CDI80879.1 - 0.97 8.7 0.0 0.97 8.7 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3959) zf-CCCH PF00642.19 CDI80880.1 - 4.3e-11 42.2 24.2 0.00026 20.5 1.6 3.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase PF00069.20 CDI80881.1 - 1e-21 77.3 0.0 1.9e-21 76.3 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI80881.1 - 2.4e-16 59.5 0.0 7.6e-16 57.9 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI80881.1 - 5.9e-09 35.3 0.0 1.9e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase GcpE PF04551.9 CDI80882.1 - 1.6e-55 188.3 0.0 1.3e-54 185.3 0.0 2.4 1 1 0 1 1 1 1 GcpE protein Galactosyl_T PF01762.16 CDI80883.1 - 1.6e-48 164.8 0.0 2e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.1 CDI80883.1 - 0.0096 15.2 0.0 0.053 12.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_hydro_114 PF03537.8 CDI80883.1 - 0.043 13.5 0.1 0.69 9.7 0.0 2.4 2 0 0 2 2 2 0 Glycoside-hydrolase family GH114 Fringe PF02434.11 CDI80883.1 - 0.088 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Galactosyl_T PF01762.16 CDI80884.1 - 9.9e-44 149.2 0.0 1.2e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 CDI80884.1 - 1.7e-05 24.1 0.0 2.2e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Fringe-like RNA_POL_M_15KD PF02150.11 CDI80885.1 - 0.96 9.1 7.9 4.6 7.0 0.1 3.5 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit PAN_4 PF14295.1 CDI80887.1 - 0.023 14.3 0.3 0.023 14.3 0.2 1.8 2 0 0 2 2 2 0 PAN domain DEAD PF00270.24 CDI80888.1 - 1.9e-42 144.5 0.0 9.4e-41 139.1 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI80888.1 - 2.1e-26 91.5 0.0 6.4e-26 90.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI80888.1 - 3.5e-05 23.7 0.3 0.0054 16.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 CDI80888.1 - 0.00036 19.9 0.1 0.00073 18.9 0.1 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain Helicase_C_2 PF13307.1 CDI80888.1 - 0.00063 19.7 0.1 1.4 8.8 0.0 2.8 3 0 0 3 3 3 2 Helicase C-terminal domain Peptidase_S49 PF01343.13 CDI80888.1 - 0.09 12.5 0.2 0.35 10.6 0.3 1.9 2 0 0 2 2 2 0 Peptidase family S49 IRK PF01007.15 CDI80890.1 - 7.1e-12 44.7 1.8 7.7e-06 24.9 0.7 2.3 2 0 0 2 2 2 2 Inward rectifier potassium channel Ion_trans_2 PF07885.11 CDI80890.1 - 0.018 14.7 3.8 0.037 13.7 2.6 1.6 1 0 0 1 1 1 0 Ion channel Dpy-30 PF05186.8 CDI80891.1 - 3.2e-11 42.5 0.2 5.6e-11 41.7 0.1 1.4 1 0 0 1 1 1 1 Dpy-30 motif WD40 PF00400.27 CDI80894.1 - 2.6e-18 65.1 0.0 1.8e-08 33.9 0.0 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.3 CDI80894.1 - 0.0012 17.1 0.1 0.0025 16.0 0.0 1.5 2 0 0 2 2 2 1 Nucleoporin Nup120/160 CD20 PF04103.10 CDI80895.1 - 0.015 15.1 0.2 0.015 15.1 0.1 4.3 4 1 0 4 4 4 0 CD20-like family DUF2431 PF10354.4 CDI80896.1 - 3.6e-06 27.0 0.0 0.00024 21.0 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF2431) PP_kinase_C PF13090.1 CDI80896.1 - 0.00074 18.2 0.0 0.11 11.0 0.0 2.0 1 1 1 2 2 2 2 Polyphosphate kinase C-terminal domain Metal_resist PF13801.1 CDI80896.1 - 0.59 10.1 3.1 3 7.8 0.2 2.3 2 0 0 2 2 2 0 Heavy-metal resistance UIM PF02809.15 CDI80896.1 - 1.3 8.8 4.2 19 5.1 0.3 2.5 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF1367 PF07105.6 CDI80899.1 - 0.0075 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1367) Bax1-I PF01027.15 CDI80899.1 - 0.0092 15.6 1.7 0.011 15.2 1.2 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 SARG PF15385.1 CDI80899.1 - 0.29 10.4 10.4 0.37 10.0 2.0 2.1 2 0 0 2 2 2 0 Specifically androgen-regulated gene protein AAA_23 PF13476.1 CDI80899.1 - 1.8 8.8 6.8 2.9 8.1 1.5 2.1 2 0 0 2 2 2 0 AAA domain PAT1 PF09770.4 CDI80899.1 - 2 6.5 24.0 0.59 8.3 0.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF2072 PF09845.4 CDI80899.1 - 2.2 8.2 4.6 0.74 9.7 1.0 1.7 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Pkinase PF00069.20 CDI80904.1 - 2.4e-33 115.4 0.0 2e-32 112.3 0.0 4.7 4 2 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI80904.1 - 2.2e-24 85.9 0.1 2.2e-24 85.9 0.1 2.9 5 0 0 5 5 5 1 Protein tyrosine kinase CAF-1_p150 PF11600.3 CDI80904.1 - 0.00023 20.6 22.5 0.00023 20.6 15.6 5.6 6 0 0 6 6 6 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal BAF1_ABF1 PF04684.8 CDI80904.1 - 0.0036 16.2 26.4 0.0036 16.2 18.3 9.6 6 4 3 9 9 9 1 BAF1 / ABF1 chromatin reorganising factor SAPS PF04499.10 CDI80907.1 - 0.019 13.6 3.8 0.028 13.0 2.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Macoilin PF09726.4 CDI80907.1 - 0.63 8.2 16.6 1.2 7.3 11.5 1.4 1 0 0 1 1 1 0 Transmembrane protein Hid1 PF12722.2 CDI80907.1 - 9.9 3.6 14.5 16 3.0 10.1 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CLP_protease PF00574.18 CDI80909.1 - 7.2e-14 51.8 0.2 7e-09 35.5 0.1 3.2 3 1 0 3 3 3 2 Clp protease AAA_23 PF13476.1 CDI80909.1 - 0.0021 18.4 4.7 0.061 13.6 0.5 2.3 2 0 0 2 2 2 2 AAA domain PIH1 PF08190.7 CDI80910.1 - 4.8e-09 36.0 14.0 4.8e-09 36.0 9.7 5.3 3 1 1 6 6 6 2 pre-RNA processing PIH1/Nop17 RNA_pol_Rpb1_5 PF04998.12 CDI80910.1 - 0.0028 16.9 0.8 1.6 7.8 1.9 2.4 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 5 UCH PF00443.24 CDI80911.1 - 0.042 12.9 4.1 0.055 12.5 2.8 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase FliL PF03748.9 CDI80911.1 - 0.15 12.0 4.9 0.3 11.1 3.4 1.5 1 0 0 1 1 1 0 Flagellar basal body-associated protein FliL DUF668 PF05003.7 CDI80911.1 - 0.16 12.1 1.4 0.53 10.5 1.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF668) AAA_23 PF13476.1 CDI80911.1 - 0.24 11.7 12.1 0.36 11.1 8.4 1.3 1 1 0 1 1 1 0 AAA domain LcrG PF07216.7 CDI80911.1 - 0.82 9.7 6.1 2.3 8.2 4.3 1.6 2 0 0 2 2 2 0 LcrG protein DUF1215 PF06744.7 CDI80911.1 - 1.1 8.8 4.3 3.2 7.4 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1215) p450 PF00067.17 CDI80911.1 - 1.2 7.6 5.3 0.21 10.0 1.1 1.6 2 1 0 2 2 2 0 Cytochrome P450 HI0933_like PF03486.9 CDI80911.1 - 1.2 7.5 3.9 1.6 7.1 2.7 1.2 1 0 0 1 1 1 0 HI0933-like protein GvpL_GvpF PF06386.6 CDI80911.1 - 2.3 7.7 6.6 3.1 7.2 4.6 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF FKBP_N PF01346.13 CDI80911.1 - 4 7.5 7.6 15 5.6 5.3 2.0 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Mitofilin PF09731.4 CDI80911.1 - 4.1 5.9 18.3 2 6.9 11.4 1.4 1 1 0 1 1 1 0 Mitochondrial inner membrane protein Activator_LAG-3 PF11498.3 CDI80911.1 - 5.5 5.6 12.7 6.5 5.3 8.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 WD40 PF00400.27 CDI80913.1 - 2.9e-10 39.6 1.1 0.009 15.8 0.0 3.9 3 1 1 4 4 4 3 WD domain, G-beta repeat WD40 PF00400.27 CDI80914.1 - 4.9e-05 23.0 2.7 0.19 11.6 0.1 4.3 3 1 0 3 3 3 2 WD domain, G-beta repeat BIV_Env PF05858.7 CDI80914.1 - 0.21 9.4 0.0 0.36 8.7 0.0 1.2 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) 60KD_IMP PF02096.15 CDI80915.1 - 0.25 10.9 5.1 0.6 9.7 3.6 1.6 1 0 0 1 1 1 0 60Kd inner membrane protein m04gp34like PF12216.3 CDI80916.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Immune evasion protein Zip PF02535.17 CDI80917.1 - 0.0081 15.2 0.1 0.015 14.3 0.1 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter PIRT PF15099.1 CDI80917.1 - 0.034 13.3 3.5 0.093 11.9 2.4 1.7 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family SieB PF14163.1 CDI80917.1 - 0.038 13.5 0.7 0.19 11.2 0.0 2.1 1 1 1 2 2 2 0 Superinfection exclusion protein B Yip1 PF04893.12 CDI80917.1 - 0.056 12.9 5.0 0.032 13.7 1.7 1.8 2 1 0 2 2 2 0 Yip1 domain DUF3995 PF13160.1 CDI80917.1 - 0.14 12.1 2.4 0.32 11.0 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3995) Tetraspannin PF00335.15 CDI80917.1 - 0.21 10.8 8.8 10 5.3 6.8 2.7 1 1 0 1 1 1 0 Tetraspanin family Glucos_trans_II PF14264.1 CDI80917.1 - 0.53 9.2 8.8 0.72 8.7 6.1 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII PPP5 PF08321.7 CDI80918.1 - 0.15 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 PPP5 TPR repeat region Ribosomal_L13 PF00572.13 CDI80921.1 - 9.1e-21 74.2 0.0 1.9e-20 73.1 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L13 AAA PF00004.24 CDI80922.1 - 3.7e-43 146.8 0.1 1.3e-42 145.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI80922.1 - 4.5e-07 30.0 0.0 0.00013 22.1 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 CDI80922.1 - 2.4e-06 27.5 0.0 6.1e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 CDI80922.1 - 2.1e-05 23.6 0.0 4.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 CDI80922.1 - 5.2e-05 22.2 0.0 8.9e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 CDI80922.1 - 5.6e-05 22.9 0.1 0.0003 20.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDI80922.1 - 7.5e-05 22.7 0.0 0.00052 20.0 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 CDI80922.1 - 0.00052 20.8 0.1 0.0017 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CDI80922.1 - 0.00066 19.5 0.0 0.0018 18.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 CDI80922.1 - 0.00085 18.7 0.3 0.047 13.0 0.1 2.3 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 CDI80922.1 - 0.0011 18.6 0.3 0.0033 17.1 0.2 1.7 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 CDI80922.1 - 0.0011 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 CDI80922.1 - 0.002 18.4 0.1 0.0056 16.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.1 CDI80922.1 - 0.0021 17.9 0.0 0.0077 16.1 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.1 CDI80922.1 - 0.0027 17.6 0.2 0.0094 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 CDI80922.1 - 0.0056 15.4 0.0 0.011 14.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.16 CDI80922.1 - 0.0069 15.5 0.4 0.017 14.2 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 CDI80922.1 - 0.0088 15.1 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.1 CDI80922.1 - 0.014 14.9 0.1 0.034 13.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDI80922.1 - 0.015 15.5 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.6 CDI80922.1 - 0.026 14.1 0.1 0.088 12.4 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 CDI80922.1 - 0.026 13.4 0.0 0.089 11.6 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.7 CDI80922.1 - 0.029 14.0 0.0 0.26 10.9 0.0 2.3 1 1 1 2 2 2 0 NACHT domain Arch_ATPase PF01637.13 CDI80922.1 - 0.034 13.8 0.1 0.26 10.9 0.0 2.3 1 1 0 1 1 1 0 Archaeal ATPase PhoH PF02562.11 CDI80922.1 - 0.043 13.0 0.1 0.11 11.6 0.1 1.6 2 0 0 2 2 1 0 PhoH-like protein NTPase_1 PF03266.10 CDI80922.1 - 0.1 12.3 0.5 0.78 9.4 0.1 2.5 2 1 0 2 2 2 0 NTPase ABC_tran PF00005.22 CDI80922.1 - 0.1 12.8 0.3 0.99 9.7 0.0 2.7 3 0 0 3 3 2 0 ABC transporter Parvo_NS1 PF01057.12 CDI80922.1 - 0.16 10.7 0.0 0.28 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.2 CDI80923.1 - 2e-21 76.2 0.0 3.4e-17 62.4 0.0 2.1 2 0 0 2 2 2 2 P-loop containing dynein motor region D3 AAA_6 PF12774.2 CDI80923.1 - 4.2e-15 55.9 0.4 0.00011 21.8 0.0 3.8 2 1 2 4 4 3 3 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 CDI80923.1 - 2.9e-11 43.2 0.0 0.011 15.4 0.0 4.3 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDI80923.1 - 1.1e-10 41.8 1.0 0.0002 21.4 0.0 3.2 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.1 CDI80923.1 - 1.3e-09 38.3 0.0 0.00018 21.6 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.1 CDI80923.1 - 1.4e-07 31.2 4.3 0.01 15.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain T2SE PF00437.15 CDI80923.1 - 8.5e-07 28.1 0.0 0.0092 14.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.1 CDI80923.1 - 1.5e-06 27.6 0.2 0.042 13.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Sigma54_activat PF00158.21 CDI80923.1 - 7.9e-06 25.4 0.2 0.0049 16.3 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.24 CDI80923.1 - 1e-05 25.7 0.0 0.0033 17.6 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 CDI80923.1 - 1.2e-05 25.1 0.0 0.0049 16.5 0.0 2.6 2 0 0 2 2 2 1 Archaeal ATPase Zeta_toxin PF06414.7 CDI80923.1 - 1.9e-05 23.8 1.0 0.018 14.1 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_19 PF13245.1 CDI80923.1 - 2.1e-05 24.1 5.0 0.018 14.7 0.0 3.7 3 0 0 3 3 3 2 Part of AAA domain AAA_14 PF13173.1 CDI80923.1 - 2.7e-05 24.0 0.0 0.0034 17.2 0.0 3.1 3 0 0 3 3 2 1 AAA domain Miro PF08477.8 CDI80923.1 - 3.6e-05 24.2 0.0 0.3 11.5 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein DUF2075 PF09848.4 CDI80923.1 - 6.3e-05 22.1 0.1 0.13 11.1 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.22 CDI80923.1 - 6.6e-05 23.2 0.3 0.19 12.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter DUF258 PF03193.11 CDI80923.1 - 6.6e-05 22.1 0.3 0.075 12.2 0.0 2.6 3 0 0 3 3 2 2 Protein of unknown function, DUF258 NB-ARC PF00931.17 CDI80923.1 - 0.00012 21.0 0.0 0.014 14.2 0.0 2.5 3 0 0 3 3 2 1 NB-ARC domain AAA_10 PF12846.2 CDI80923.1 - 0.00013 21.5 1.6 1.1 8.6 0.0 3.3 3 0 0 3 3 3 1 AAA-like domain AAA_17 PF13207.1 CDI80923.1 - 0.00019 22.2 0.2 0.06 14.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CDI80923.1 - 0.0002 21.0 0.2 0.19 11.3 0.0 2.7 3 0 0 3 3 2 1 NACHT domain Viral_helicase1 PF01443.13 CDI80923.1 - 0.0002 20.9 0.1 0.045 13.2 0.0 2.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Guanylate_kin PF00625.16 CDI80923.1 - 0.00027 20.4 0.1 0.048 13.1 0.0 2.5 2 0 0 2 2 2 1 Guanylate kinase DUF815 PF05673.8 CDI80923.1 - 0.00034 19.6 0.4 0.39 9.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.1 CDI80923.1 - 0.00049 20.1 0.2 0.066 13.2 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.1 CDI80923.1 - 0.00053 19.8 0.0 0.45 10.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 CDI80923.1 - 0.0017 17.9 0.7 1.2 8.6 0.0 2.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 CDI80923.1 - 0.0018 18.5 0.1 0.21 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.4 CDI80923.1 - 0.002 16.8 0.1 0.57 8.7 0.0 2.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.17 CDI80923.1 - 0.0021 18.2 0.0 0.57 10.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.18 CDI80923.1 - 0.0026 17.6 0.1 2 8.3 0.1 3.0 3 0 0 3 3 2 1 50S ribosome-binding GTPase Mg_chelatase PF01078.16 CDI80923.1 - 0.0031 16.7 3.0 0.19 10.8 0.0 2.6 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI cobW PF02492.14 CDI80923.1 - 0.0031 16.9 0.1 0.065 12.6 0.0 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 CDI80923.1 - 0.0037 17.2 0.1 1.1 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 CDI80923.1 - 0.0042 16.7 0.2 0.051 13.2 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 UvrD-helicase PF00580.16 CDI80923.1 - 0.0043 16.4 0.5 0.66 9.2 0.2 2.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DUF87 PF01935.12 CDI80923.1 - 0.0091 15.8 0.7 0.24 11.1 0.0 2.8 3 0 0 3 3 2 1 Domain of unknown function DUF87 AAA_23 PF13476.1 CDI80923.1 - 0.0093 16.3 2.1 1.2 9.4 0.0 2.9 3 0 0 3 3 2 1 AAA domain SRPRB PF09439.5 CDI80923.1 - 0.014 14.5 0.1 0.12 11.5 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MobB PF03205.9 CDI80923.1 - 0.019 14.6 0.0 6.8 6.4 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 CDI80923.1 - 0.025 14.0 0.3 0.49 9.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_25 PF13481.1 CDI80923.1 - 0.027 13.8 0.2 1.6 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Septin PF00735.13 CDI80923.1 - 0.031 13.2 0.0 1 8.3 0.0 2.2 2 0 0 2 2 2 0 Septin ATP_bind_1 PF03029.12 CDI80923.1 - 0.042 13.3 0.2 5.3 6.4 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.12 CDI80923.1 - 0.048 13.0 0.3 4.8 6.5 0.0 2.7 2 1 1 3 3 3 0 IstB-like ATP binding protein Gtr1_RagA PF04670.7 CDI80923.1 - 0.051 12.6 0.0 1.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region NTPase_1 PF03266.10 CDI80923.1 - 0.073 12.7 0.0 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 NTPase SRP54 PF00448.17 CDI80923.1 - 0.076 12.4 0.2 10 5.4 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AIG1 PF04548.11 CDI80923.1 - 0.09 11.8 0.3 1.8 7.5 0.0 2.5 3 0 0 3 3 2 0 AIG1 family APS_kinase PF01583.15 CDI80923.1 - 0.11 12.1 0.2 1 9.0 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_35 PF14516.1 CDI80923.1 - 0.15 10.6 1.0 0.2 10.2 0.0 1.6 2 0 0 2 2 1 0 AAA-like domain TIP49 PF06068.8 CDI80923.1 - 0.27 9.8 0.9 1.9 7.0 0.0 2.0 2 0 0 2 2 2 0 TIP49 C-terminus Ribosomal_60s PF00428.14 CDI80923.1 - 0.29 11.5 31.4 0.077 13.4 6.6 3.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein G-alpha PF00503.15 CDI80923.1 - 1 7.9 6.2 0.84 8.2 0.1 2.5 2 1 0 2 2 2 0 G-protein alpha subunit SprA-related PF12118.3 CDI80925.1 - 0.011 15.1 26.8 0.01 15.2 18.6 1.1 1 0 0 1 1 1 0 SprA-related family RR_TM4-6 PF06459.7 CDI80925.1 - 0.019 14.8 9.4 0.018 14.9 6.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.8 CDI80925.1 - 0.024 14.5 24.8 0.023 14.5 17.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.17 CDI80925.1 - 0.18 10.7 0.5 0.19 10.7 0.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CHASE2 PF05226.6 CDI80925.1 - 0.55 9.4 7.7 0.75 8.9 5.3 1.2 1 0 0 1 1 1 0 CHASE2 domain Hid1 PF12722.2 CDI80925.1 - 0.78 7.3 10.7 0.76 7.3 7.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.1 CDI80925.1 - 1.8 8.2 12.3 2.2 7.9 8.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF605 PF04652.11 CDI80925.1 - 8.2 5.7 25.5 9.7 5.4 17.7 1.1 1 0 0 1 1 1 0 Vta1 like YjgP_YjgQ PF03739.9 CDI80925.1 - 8.8 4.9 6.0 8.7 4.9 4.2 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Sel1 PF08238.7 CDI80926.1 - 3.6e-28 97.3 18.4 1.4e-05 25.5 0.0 10.9 10 0 0 10 10 10 8 Sel1 repeat FLO_LFY PF01698.11 CDI80926.1 - 6.4 5.5 16.9 0.67 8.7 7.3 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein PAG PF15347.1 CDI80928.1 - 0.028 13.5 0.0 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched LST1 PF05083.8 CDI80928.1 - 0.11 12.4 0.0 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 LST-1 protein DUF1510 PF07423.6 CDI80929.1 - 0.00028 20.3 10.6 0.00033 20.1 7.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Peptidase_S49_N PF08496.5 CDI80929.1 - 0.0013 18.5 6.1 0.0017 18.2 4.2 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal RNase_H2-Ydr279 PF09468.5 CDI80929.1 - 0.004 16.3 5.5 0.0046 16.2 3.8 1.1 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) Trypan_PARP PF05887.6 CDI80929.1 - 0.004 16.9 0.3 0.0046 16.7 0.2 1.1 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Zip PF02535.17 CDI80929.1 - 0.0091 15.0 0.5 0.011 14.7 0.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Ycf1 PF05758.7 CDI80929.1 - 0.013 13.2 9.3 0.014 13.1 6.5 1.0 1 0 0 1 1 1 0 Ycf1 PA26 PF04636.8 CDI80929.1 - 0.014 14.1 3.3 0.015 14.0 2.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hid1 PF12722.2 CDI80929.1 - 0.019 12.6 6.1 0.02 12.6 4.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAGA-Tad1 PF12767.2 CDI80929.1 - 0.022 14.4 8.8 0.025 14.2 6.1 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DDHD PF02862.12 CDI80929.1 - 0.024 14.4 9.8 0.028 14.2 6.8 1.1 1 0 0 1 1 1 0 DDHD domain DUF2457 PF10446.4 CDI80929.1 - 0.027 13.2 8.4 0.031 13.0 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Folate_carrier PF01770.13 CDI80929.1 - 0.049 12.1 1.4 0.055 11.9 1.0 1.3 1 0 0 1 1 1 0 Reduced folate carrier DUF1980 PF09323.5 CDI80929.1 - 0.054 13.2 4.4 0.079 12.7 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) HemY_N PF07219.8 CDI80929.1 - 0.056 13.0 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 HemY protein N-terminus NARP1 PF12569.3 CDI80929.1 - 0.063 12.0 9.8 0.065 11.9 6.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Cytomega_UL84 PF06284.6 CDI80929.1 - 0.075 11.4 5.8 0.094 11.1 4.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Neur_chan_memb PF02932.11 CDI80929.1 - 0.088 12.6 2.0 0.092 12.6 1.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OATP PF03137.15 CDI80929.1 - 0.11 10.5 0.8 0.11 10.5 0.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Serinc PF03348.10 CDI80929.1 - 0.11 11.2 4.3 0.13 10.9 3.0 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4557 PF15101.1 CDI80929.1 - 0.13 12.0 14.4 0.17 11.7 10.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Tim54 PF11711.3 CDI80929.1 - 0.13 10.7 9.3 0.15 10.6 6.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 OmpH PF03938.9 CDI80929.1 - 0.16 11.9 30.6 0.22 11.4 21.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2215 PF10225.4 CDI80929.1 - 0.16 11.3 3.2 0.21 11.0 2.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) DUF2126 PF09899.4 CDI80929.1 - 0.16 9.9 5.9 0.19 9.7 4.1 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) HemX PF04375.9 CDI80929.1 - 0.17 10.4 17.6 0.18 10.3 12.2 1.1 1 0 0 1 1 1 0 HemX DUF4220 PF13968.1 CDI80929.1 - 0.17 10.9 2.1 0.21 10.6 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF3987 PF13148.1 CDI80929.1 - 0.19 10.2 7.3 0.22 10.0 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) SID-1_RNA_chan PF13965.1 CDI80929.1 - 0.22 9.6 4.3 0.24 9.4 3.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ndc1_Nup PF09531.5 CDI80929.1 - 0.23 9.8 5.0 0.23 9.8 3.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2201_N PF13203.1 CDI80929.1 - 0.27 10.3 9.9 0.3 10.2 6.8 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain GAGA_bind PF06217.7 CDI80929.1 - 0.28 11.0 11.6 0.34 10.8 8.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Paramyxo_ncap PF00973.14 CDI80929.1 - 0.29 9.7 7.4 0.31 9.6 5.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AUX_IAA PF02309.11 CDI80929.1 - 0.35 10.5 9.1 0.41 10.3 6.3 1.1 1 0 0 1 1 1 0 AUX/IAA family RepA_C PF04796.7 CDI80929.1 - 0.37 10.4 3.4 0.51 9.9 2.3 1.3 1 0 0 1 1 1 0 Plasmid encoded RepA protein MCPVI PF02993.9 CDI80929.1 - 0.38 10.8 13.8 0.52 10.4 9.5 1.2 1 0 0 1 1 1 0 Minor capsid protein VI MRP-S26 PF14943.1 CDI80929.1 - 0.42 10.1 20.3 0.54 9.7 14.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 BTV_NS2 PF04514.7 CDI80929.1 - 0.42 9.4 11.1 0.45 9.3 7.7 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Inhibitor_I71 PF12628.2 CDI80929.1 - 0.43 10.2 5.0 0.59 9.7 3.5 1.2 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor DUF3573 PF12097.3 CDI80929.1 - 0.44 9.1 5.2 0.53 8.8 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) SAPS PF04499.10 CDI80929.1 - 0.44 9.1 13.1 0.52 8.8 9.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4045 PF13254.1 CDI80929.1 - 0.46 9.7 11.7 0.55 9.4 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Mem_trans PF03547.13 CDI80929.1 - 0.47 8.6 2.6 0.53 8.5 1.8 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF2052 PF09747.4 CDI80929.1 - 0.47 10.3 23.5 0.55 10.1 16.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF853 PF05872.7 CDI80929.1 - 0.48 8.7 9.0 0.54 8.5 6.2 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Exonuc_VII_L PF02601.10 CDI80929.1 - 0.52 9.4 10.4 0.59 9.2 7.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2347 PF09804.4 CDI80929.1 - 0.53 9.5 4.0 0.57 9.4 2.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Med17 PF10156.4 CDI80929.1 - 0.55 8.4 18.5 0.64 8.2 12.8 1.0 1 0 0 1 1 1 0 Subunit 17 of Mediator complex KfrA_N PF11740.3 CDI80929.1 - 0.61 10.5 25.3 1.1 9.7 17.6 1.4 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term YqfQ PF14181.1 CDI80929.1 - 0.62 10.0 17.6 0.78 9.7 12.2 1.1 1 0 0 1 1 1 0 YqfQ-like protein CDC45 PF02724.9 CDI80929.1 - 0.66 7.9 15.7 0.81 7.6 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Caldesmon PF02029.10 CDI80929.1 - 0.75 8.1 20.5 0.83 8.0 14.2 1.0 1 0 0 1 1 1 0 Caldesmon Band_3_cyto PF07565.8 CDI80929.1 - 0.76 9.2 9.7 0.88 9.0 6.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF342 PF03961.8 CDI80929.1 - 0.92 7.8 14.4 1.1 7.6 10.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) RR_TM4-6 PF06459.7 CDI80929.1 - 0.93 9.3 16.6 1.1 9.1 11.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM222A PF15258.1 CDI80929.1 - 0.95 8.5 11.6 1.1 8.3 8.1 1.1 1 0 0 1 1 1 0 Protein family of FAM222A Pilt PF15453.1 CDI80929.1 - 0.98 9.0 13.2 1.1 8.8 9.1 1.0 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions DUF4011 PF13195.1 CDI80929.1 - 1 9.3 9.5 1.3 9.0 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) Calc_CGRP_IAPP PF00214.14 CDI80929.1 - 1.1 9.3 5.3 1.5 8.8 3.7 1.3 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family FLO_LFY PF01698.11 CDI80929.1 - 1.2 7.8 11.8 1.4 7.6 8.2 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Peptidase_S30 PF01577.11 CDI80929.1 - 1.3 8.3 13.6 1.7 7.9 9.4 1.1 1 0 0 1 1 1 0 Potyvirus P1 protease Suf PF05843.9 CDI80929.1 - 1.3 8.6 13.1 1.6 8.3 9.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Plasmodium_Vir PF05795.6 CDI80929.1 - 1.4 8.0 5.5 1.6 7.8 3.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TP53IP5 PF15331.1 CDI80929.1 - 1.4 8.7 12.9 1.7 8.4 8.9 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 V_ATPase_I PF01496.14 CDI80929.1 - 1.4 6.6 9.5 1.5 6.5 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Daxx PF03344.10 CDI80929.1 - 1.5 7.2 20.1 1.6 7.1 13.9 1.0 1 0 0 1 1 1 0 Daxx Family Drc1-Sld2 PF11719.3 CDI80929.1 - 1.5 7.8 16.5 1.8 7.5 11.5 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein Gag_spuma PF03276.9 CDI80929.1 - 1.5 7.0 15.8 1.8 6.8 11.0 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Paf1 PF03985.8 CDI80929.1 - 1.5 7.4 23.6 1.9 7.1 16.4 1.0 1 0 0 1 1 1 0 Paf1 DUF1266 PF06889.6 CDI80929.1 - 1.6 8.5 11.1 2.1 8.1 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) BPL_N PF09825.4 CDI80929.1 - 1.6 7.4 5.9 1.8 7.2 4.1 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF4407 PF14362.1 CDI80929.1 - 1.7 7.5 15.1 2.8 6.8 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SMN PF06003.7 CDI80929.1 - 1.8 7.5 4.8 2 7.4 3.3 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Het-C PF07217.6 CDI80929.1 - 1.9 6.5 10.7 2.3 6.3 7.4 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C GNT-I PF03071.10 CDI80929.1 - 2 6.8 6.7 2.2 6.7 4.7 1.1 1 0 0 1 1 1 0 GNT-I family FAM176 PF14851.1 CDI80929.1 - 2.1 8.0 10.0 3.4 7.3 6.9 1.4 1 0 0 1 1 1 0 FAM176 family Vfa1 PF08432.5 CDI80929.1 - 2.1 8.3 17.9 2.6 8.0 12.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GOLD_2 PF13897.1 CDI80929.1 - 2.1 8.5 7.8 2.9 8.1 5.4 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF1800 PF08811.6 CDI80929.1 - 2.7 6.8 14.2 3.2 6.5 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) HAUS6_N PF14661.1 CDI80929.1 - 2.7 7.2 16.6 3.2 7.0 11.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus SpoIIP PF07454.6 CDI80929.1 - 3 6.9 14.6 3.7 6.6 10.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Sporozoite_P67 PF05642.6 CDI80929.1 - 3.1 5.5 11.3 3.5 5.3 7.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HSP70 PF00012.15 CDI80929.1 - 3.3 5.5 14.9 3.7 5.3 10.3 1.0 1 0 0 1 1 1 0 Hsp70 protein YABBY PF04690.8 CDI80929.1 - 3.3 7.9 7.6 4.1 7.6 5.3 1.2 1 0 0 1 1 1 0 YABBY protein Pox_Ag35 PF03286.9 CDI80929.1 - 3.4 7.1 13.4 5 6.5 9.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PBP1_TM PF14812.1 CDI80929.1 - 3.8 7.8 11.8 6.6 7.1 8.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HSP90 PF00183.13 CDI80929.1 - 3.9 5.7 15.1 4.6 5.5 10.5 1.1 1 0 0 1 1 1 0 Hsp90 protein Prog_receptor PF02161.10 CDI80929.1 - 4.1 6.1 9.5 4.7 5.9 6.6 1.1 1 0 0 1 1 1 0 Progesterone receptor Parvo_coat PF00740.13 CDI80929.1 - 4.1 6.2 11.8 4.9 5.9 8.2 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 DUF3449 PF11931.3 CDI80929.1 - 4.4 6.7 17.7 5.6 6.4 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) SprA-related PF12118.3 CDI80929.1 - 4.6 6.4 31.6 5.6 6.2 21.9 1.1 1 0 0 1 1 1 0 SprA-related family AIF_C PF14721.1 CDI80929.1 - 4.8 7.4 10.9 6.5 7.0 7.5 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RP-C_C PF11800.3 CDI80929.1 - 4.8 6.8 12.9 5.9 6.5 8.9 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Endonuc_Holl PF10107.4 CDI80929.1 - 5 6.7 16.2 6.7 6.3 11.2 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Phlebovirus_NSM PF07246.6 CDI80929.1 - 5.2 6.1 11.1 6.8 5.7 7.7 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Asp-B-Hydro_N PF05279.6 CDI80929.1 - 5.3 6.8 21.0 6.4 6.5 14.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3381 PF11861.3 CDI80929.1 - 5.6 6.4 21.5 7.5 6.0 14.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) EIIBC-GUT_N PF03612.9 CDI80929.1 - 5.7 6.5 9.8 7.5 6.1 6.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CPSF100_C PF13299.1 CDI80929.1 - 5.7 7.1 12.7 6.9 6.8 8.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal P16-Arc PF04699.9 CDI80929.1 - 5.9 6.8 13.9 1.3 8.9 7.0 1.7 1 1 1 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Gti1_Pac2 PF09729.4 CDI80929.1 - 6 6.7 8.5 7.8 6.3 5.9 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Peptidase_U57 PF05582.7 CDI80929.1 - 6 5.7 11.7 7 5.5 8.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF4637 PF15470.1 CDI80929.1 - 6.1 6.4 9.0 8.2 6.0 6.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Rtf2 PF04641.7 CDI80929.1 - 6.2 5.9 15.4 7.9 5.6 10.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Cob_adeno_trans PF01923.13 CDI80929.1 - 6.5 6.5 10.0 8.8 6.0 7.0 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Fmp27 PF10344.4 CDI80929.1 - 6.6 4.2 14.5 8.3 3.9 10.0 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 SeqA PF03925.8 CDI80929.1 - 6.7 6.3 13.0 8.4 6.0 9.0 1.1 1 0 0 1 1 1 0 SeqA protein AAA_11 PF13086.1 CDI80929.1 - 6.9 6.1 14.6 8.3 5.8 10.1 1.1 1 0 0 1 1 1 0 AAA domain FAM60A PF15396.1 CDI80929.1 - 7.1 6.3 9.9 9.3 5.9 6.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF3306 PF11748.3 CDI80929.1 - 7.1 7.3 14.7 11 6.6 10.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) APG6 PF04111.7 CDI80929.1 - 7.4 5.5 23.5 9.7 5.1 16.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 TEX19 PF15553.1 CDI80929.1 - 8.4 6.2 13.2 11 5.7 9.1 1.1 1 0 0 1 1 1 0 Testis-expressed protein 19 Spore_coat_CotO PF14153.1 CDI80929.1 - 8.7 5.7 27.4 11 5.4 19.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO ZYG-11_interact PF05884.7 CDI80929.1 - 9.3 5.2 11.5 13 4.7 8.0 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 VID27 PF08553.5 CDI80929.1 - 9.3 4.3 15.9 11 4.1 11.0 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Med15 PF09606.5 CDI80929.1 - 9.7 4.2 32.6 11 4.0 22.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal GDA1_CD39 PF01150.12 CDI80930.1 - 4.2e-47 160.6 0.0 9.1e-47 159.5 0.0 1.5 2 0 0 2 2 2 1 GDA1/CD39 (nucleoside phosphatase) family RabGAP-TBC PF00566.13 CDI80931.1 - 2.7e-33 115.2 0.4 1.2e-16 60.9 0.0 3.0 2 1 0 2 2 2 2 Rab-GTPase-TBC domain Mucin PF01456.12 CDI80932.1 - 1.8e-06 27.7 5.4 3e-06 27.0 3.8 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.6 CDI80932.1 - 0.17 9.8 11.5 0.26 9.2 8.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Sec7 PF01369.15 CDI80935.1 - 9.9e-63 211.2 0.0 1.7e-62 210.4 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 CDI80935.1 - 2.5e-12 46.5 0.0 8.8e-12 44.7 0.0 2.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal PapD-like PF14874.1 CDI80936.1 - 0.28 11.1 1.5 12 5.9 0.0 3.5 4 0 0 4 4 4 0 Flagellar-associated PapD-like PAZ PF02170.17 CDI80937.1 - 2.5e-09 36.5 0.1 1.2e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 PAZ domain Piwi PF02171.12 CDI80937.1 - 1.3e-08 34.1 0.0 1.2e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 Piwi domain RNA_pol_Rpb1_6 PF04992.9 CDI80937.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 WGG PF10273.4 CDI80938.1 - 1.3e-25 89.2 1.0 2.8e-25 88.1 0.7 1.6 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.2 CDI80938.1 - 0.0019 18.2 1.4 0.0047 16.9 0.1 2.2 1 1 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) Tautomerase_2 PF14552.1 CDI80938.1 - 0.058 13.4 0.1 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 Tautomerase enzyme AMP-binding_C_2 PF14535.1 CDI80938.1 - 0.11 12.6 0.1 0.88 9.6 0.0 2.3 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain TPR_11 PF13414.1 CDI80939.1 - 1e-07 31.4 22.0 7.6e-06 25.4 3.5 4.4 3 1 1 4 4 4 2 TPR repeat TPR_2 PF07719.12 CDI80939.1 - 1.4e-07 30.8 14.3 0.0035 17.1 0.4 4.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 CDI80939.1 - 7.6e-06 25.3 11.4 0.052 13.1 0.6 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 CDI80939.1 - 0.024 14.3 3.6 1.1 9.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat P12 PF12669.2 CDI80940.1 - 0.0045 17.1 1.7 0.0045 17.1 1.2 4.2 5 0 0 5 5 5 1 Virus attachment protein p12 family Sporozoite_P67 PF05642.6 CDI80941.1 - 0.079 10.8 3.4 0.26 9.1 2.4 1.8 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DcuC PF03606.10 CDI80941.1 - 0.23 9.6 2.0 0.39 8.8 0.0 2.2 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier DUF755 PF05501.6 CDI80942.1 - 0.054 13.5 19.6 0.062 13.3 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SR-25 PF10500.4 CDI80942.1 - 0.23 10.8 17.2 0.27 10.6 11.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2489 PF10675.4 CDI80942.1 - 0.48 10.0 4.6 0.54 9.9 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) CDK2AP PF09806.4 CDI80942.1 - 1.4 9.1 7.7 1.5 9.0 5.3 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Hydrolase PF00702.21 CDI80947.1 - 3e-35 122.5 6.3 3e-35 122.5 4.4 2.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CDI80947.1 - 7.2e-30 103.7 0.0 3.3e-15 55.7 0.0 2.9 2 1 0 2 2 2 2 E1-E2 ATPase HAD PF12710.2 CDI80947.1 - 1.1e-12 48.5 0.0 2.4e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDI80947.1 - 0.0042 16.6 4.8 0.062 12.8 0.5 2.9 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CDI80947.1 - 0.013 15.7 0.1 0.067 13.4 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Zip PF02535.17 CDI80947.1 - 0.16 10.9 2.7 0.55 9.1 1.9 1.8 1 1 0 1 1 1 0 ZIP Zinc transporter Spt20 PF12090.3 CDI80947.1 - 1.1 8.6 13.5 3.4 6.9 0.1 3.3 4 0 0 4 4 4 0 Spt20 family Neur_chan_memb PF02932.11 CDI80947.1 - 1.4 8.7 4.6 0.36 10.6 0.8 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.2 CDI80947.1 - 8.3 3.9 9.0 14 3.1 6.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Paf67 PF10255.4 CDI80959.1 - 3.3e-93 312.7 0.2 1e-91 307.8 0.1 2.2 1 1 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 CDI80959.1 - 0.011 15.5 1.4 0.022 14.6 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1440 PF07274.7 CDI80959.1 - 0.11 12.4 0.3 0.37 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1440) NT-C2 PF10358.4 CDI80960.1 - 5.8e-06 25.8 0.0 0.0025 17.3 0.0 2.8 3 0 0 3 3 3 2 N-terminal C2 in EEIG1 and EHBP1 proteins Pkinase PF00069.20 CDI80964.1 - 1.3e-22 80.2 0.0 1.3e-22 80.2 0.0 3.1 2 2 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 CDI80964.1 - 1.4e-19 70.2 0.0 1.4e-19 70.2 0.0 3.1 2 1 0 2 2 2 1 Kinase-like Pkinase_Tyr PF07714.12 CDI80964.1 - 2.7e-09 36.4 0.1 1.9e-08 33.7 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase LRR_8 PF13855.1 CDI80965.1 - 9.4e-07 28.4 39.9 0.00019 21.1 1.1 4.4 5 0 0 5 5 5 3 Leucine rich repeat LRR_4 PF12799.2 CDI80965.1 - 1.3e-05 24.7 50.9 0.1 12.2 6.1 6.6 4 2 2 6 6 6 6 Leucine Rich repeats (2 copies) HAD_2 PF13419.1 CDI80966.1 - 0.15 12.2 1.9 0.25 11.5 1.3 1.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Anoctamin PF04547.7 CDI80966.1 - 1.2 7.6 7.5 1.7 7.1 5.2 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel SOBP PF15279.1 CDI80966.1 - 2.5 8.4 31.8 3.1 8.0 22.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Myb_DNA-binding PF00249.26 CDI80968.1 - 4.4e-10 39.4 0.0 8.6e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDI80968.1 - 5.9e-08 32.6 0.0 1.2e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 CDI80968.1 - 0.022 14.8 0.4 1 9.5 0.0 2.8 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF2201_N PF13203.1 CDI80968.1 - 0.25 10.4 7.3 0.46 9.6 5.1 1.5 1 0 0 1 1 1 0 Putative metallopeptidase domain Sec3_C PF09763.4 CDI80970.1 - 3.6 5.6 7.0 5.4 5.0 4.9 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 TAXi_C PF14541.1 CDI80971.1 - 0.00079 19.0 0.0 0.58 9.6 0.0 3.0 3 0 0 3 3 3 2 Xylanase inhibitor C-terminal PAT1 PF09770.4 CDI80971.1 - 0.0017 16.6 50.3 0.0017 16.6 34.9 4.5 4 1 0 4 4 4 2 Topoisomerase II-associated protein PAT1 Asp PF00026.18 CDI80971.1 - 0.0019 17.5 16.7 0.11 11.7 0.0 4.5 3 2 1 4 4 4 1 Eukaryotic aspartyl protease LMBR1 PF04791.11 CDI80971.1 - 0.044 12.3 5.0 0.099 11.2 3.5 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Ycf1 PF05758.7 CDI80971.1 - 1.2 6.7 30.8 0.014 13.1 9.6 3.0 3 0 0 3 3 3 0 Ycf1 Profilin PF00235.14 CDI80973.1 - 1.8e-11 44.2 0.4 2.7e-11 43.6 0.3 1.3 1 1 0 1 1 1 1 Profilin Peptidase_C25_C PF03785.9 CDI80973.1 - 0.025 14.4 0.3 0.86 9.4 0.1 2.2 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain Maf PF02545.9 CDI80979.1 - 1.3e-33 115.7 8.0 2.2e-14 53.0 0.2 3.3 1 1 2 3 3 3 3 Maf-like protein DUF4557 PF15101.1 CDI80979.1 - 0.0039 17.0 9.7 0.0039 17.0 6.7 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4557) Dehydrin PF00257.14 CDI80979.1 - 0.011 16.0 9.4 0.011 16.0 6.5 3.3 3 1 0 3 3 3 0 Dehydrin Porphobil_deamC PF03900.10 CDI80979.1 - 0.13 12.4 0.4 0.33 11.1 0.3 1.7 1 0 0 1 1 1 0 Porphobilinogen deaminase, C-terminal domain PIN_3 PF13470.1 CDI80979.1 - 0.28 11.8 2.9 0.78 10.4 0.0 2.4 2 1 0 2 2 2 0 PIN domain Bac_luciferase PF00296.15 CDI80979.1 - 0.3 10.1 4.5 0.57 9.2 0.6 2.2 2 1 0 2 2 2 0 Luciferase-like monooxygenase AAA_23 PF13476.1 CDI80979.1 - 0.57 10.4 19.2 0.55 10.5 6.7 2.2 2 0 0 2 2 2 0 AAA domain PAT1 PF09770.4 CDI80979.1 - 0.71 8.0 49.8 0.57 8.3 9.9 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 CDI80979.1 - 0.84 7.2 52.8 0.2 9.3 11.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) RNase_HII PF01351.13 CDI80981.1 - 1.3e-23 83.6 4.4 9.1e-10 38.5 0.0 3.2 2 1 1 3 3 3 3 Ribonuclease HII PASTA PF03793.14 CDI80981.1 - 0.076 12.6 0.0 0.24 11.0 0.0 1.8 1 0 0 1 1 1 0 PASTA domain PepX_C PF08530.5 CDI80981.1 - 0.1 12.4 0.7 0.16 11.8 0.5 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_8 PF06259.7 CDI80982.1 - 0.0005 19.6 0.0 0.00073 19.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase Phage_holin_3 PF05106.7 CDI80985.1 - 0.12 12.4 0.2 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) ALAD PF00490.16 CDI80987.1 - 4.1e-129 430.1 0.1 8.5e-85 284.4 1.0 2.2 2 0 0 2 2 2 2 Delta-aminolevulinic acid dehydratase Peptidase_M16_C PF05193.16 CDI80987.1 - 2.2e-24 86.1 0.4 1.4e-11 44.3 0.0 3.6 2 2 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CDI80987.1 - 2.7e-15 56.4 0.8 2.4e-13 50.0 0.7 2.9 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) PEP-utilisers_N PF05524.8 CDI80987.1 - 0.7 9.6 7.3 3.5 7.4 0.1 3.7 4 0 0 4 4 4 0 PEP-utilising enzyme, N-terminal Nop14 PF04147.7 CDI80987.1 - 3.9 5.2 8.2 5.9 4.6 5.7 1.1 1 0 0 1 1 1 0 Nop14-like family Ebola_NP PF05505.7 CDI80987.1 - 5 5.0 3.3 8.5 4.2 2.3 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein Methyltransf_18 PF12847.2 CDI80989.1 - 5.9e-11 42.9 0.0 3e-10 40.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI80989.1 - 1.5e-09 37.6 0.2 3.3e-07 30.0 0.1 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.1 CDI80989.1 - 1.3e-07 31.4 0.0 3.5e-07 30.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI80989.1 - 2.3e-07 31.1 0.0 9e-06 26.0 0.0 2.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI80989.1 - 4.1e-07 30.2 0.5 9.8e-07 29.0 0.2 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI80989.1 - 6.4e-06 26.1 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI80989.1 - 0.00022 21.6 0.1 0.00064 20.1 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDI80989.1 - 0.015 14.6 0.0 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 CDI80989.1 - 0.023 13.8 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Pox_MCEL PF03291.11 CDI80989.1 - 0.042 12.7 0.1 0.089 11.6 0.0 1.5 2 0 0 2 2 2 0 mRNA capping enzyme Pox_A12 PF04651.8 CDI80989.1 - 0.059 13.4 4.9 0.76 9.8 2.6 2.4 2 0 0 2 2 2 0 Poxvirus A12 protein EF-hand_1 PF00036.27 CDI80991.1 - 8.4e-05 21.5 0.0 0.00056 19.0 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 CDI80991.1 - 0.00032 20.7 0.2 0.0015 18.6 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 CDI80991.1 - 0.00086 18.9 0.0 0.0027 17.4 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 CDI80991.1 - 0.053 12.8 0.0 0.24 10.7 0.0 2.1 2 0 0 2 2 2 0 EF hand BUD22 PF09073.5 CDI80993.1 - 0.021 13.9 1.9 0.037 13.1 1.3 1.3 1 0 0 1 1 1 0 BUD22 HSP90 PF00183.13 CDI80994.1 - 1.4e-260 865.2 42.4 1.7e-260 864.9 29.4 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 CDI80994.1 - 3.9e-12 45.8 0.0 7.6e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 CDI80994.1 - 1.7e-10 40.6 0.1 1.7e-10 40.6 0.1 2.4 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.4 CDI80994.1 - 0.0045 16.7 1.0 0.012 15.3 0.2 2.2 2 0 0 2 2 2 1 Tumour suppressor protein DUF1510 PF07423.6 CDI80994.1 - 0.015 14.7 21.9 0.041 13.2 15.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.12 CDI80994.1 - 1.6 8.5 14.6 0.17 11.6 6.5 1.9 2 0 0 2 2 2 0 DDHD domain DUF2201_N PF13203.1 CDI80994.1 - 4.5 6.3 8.5 8.1 5.5 5.9 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain FimP PF09766.4 CDI80995.1 - 0.00034 19.8 6.9 0.00034 19.8 4.8 3.6 4 0 0 4 4 4 2 Fms-interacting protein IncA PF04156.9 CDI80995.1 - 0.00046 19.8 5.7 0.00046 19.8 4.0 5.0 4 1 0 4 4 4 1 IncA protein Ribosomal_60s PF00428.14 CDI80995.1 - 0.018 15.4 6.3 0.018 15.4 4.4 10.0 4 1 3 7 7 7 0 60s Acidic ribosomal protein PBP1_TM PF14812.1 CDI80995.1 - 0.031 14.5 33.5 0.21 11.9 7.1 4.5 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Helicase_C_2 PF13307.1 CDI80996.1 - 2e-42 144.9 0.0 2e-42 144.9 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain Hid1 PF12722.2 CDI80996.1 - 0.26 8.9 5.2 0.32 8.6 3.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Baculo_PP31 PF05311.6 CDI80996.1 - 0.31 10.2 5.8 0.46 9.7 4.0 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) BAF1_ABF1 PF04684.8 CDI80996.1 - 0.33 9.7 21.9 0.59 8.9 15.2 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF966 PF06136.8 CDI80996.1 - 0.96 8.7 11.7 1.6 8.0 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) RRM_1 PF00076.17 CDI80997.1 - 2.4e-74 244.9 0.0 9.1e-21 73.2 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI80997.1 - 1.4e-52 175.5 0.0 1e-16 60.6 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI80997.1 - 2.9e-41 139.1 0.0 7.3e-10 38.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 CDI80997.1 - 2.3e-31 107.2 2.2 1.4e-30 104.7 1.5 2.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Glycolytic PF00274.14 CDI80998.1 - 3.6e-124 413.6 0.0 4e-124 413.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I DUF972 PF06156.8 CDI80999.1 - 0.0049 17.1 0.1 0.0049 17.1 0.1 3.9 4 0 0 4 4 4 1 Protein of unknown function (DUF972) URO-D PF01208.12 CDI80999.1 - 0.52 9.1 2.3 0.45 9.3 0.1 1.8 2 0 0 2 2 2 0 Uroporphyrinogen decarboxylase (URO-D) rRNA_proc-arch PF13234.1 CDI81000.1 - 6.2e-19 68.1 0.0 9.4e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.24 CDI81000.1 - 7.6e-12 45.0 0.1 1.5e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI81000.1 - 2.7e-07 30.3 0.0 6.9e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Sds3 PF08598.6 CDI81000.1 - 3.5 7.1 7.2 1.7 8.1 2.4 2.1 2 0 0 2 2 2 0 Sds3-like DUF3941 PF13081.1 CDI81001.1 - 7.7 6.5 8.6 6 6.9 5.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3941) HSP90 PF00183.13 CDI81002.1 - 5.6e-114 381.4 0.4 1.5e-68 231.4 0.2 4.1 2 2 2 4 4 4 4 Hsp90 protein HATPase_c_3 PF13589.1 CDI81002.1 - 3.1e-10 39.8 0.0 6.5e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDI81002.1 - 3.3e-07 29.9 0.2 8.8e-07 28.6 0.1 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MIase PF02426.11 CDI81002.1 - 0.036 13.8 0.2 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 Muconolactone delta-isomerase Aminotran_5 PF00266.14 CDI81004.1 - 7.9e-19 67.6 0.0 1.6e-13 50.1 0.0 2.6 2 1 0 2 2 2 2 Aminotransferase class-V Pentapeptide PF00805.17 CDI81005.1 - 1.7e-48 161.1 69.6 0.0057 15.8 0.2 24.8 9 6 14 26 26 26 22 Pentapeptide repeats (8 copies) Ribosomal_L2_C PF03947.13 CDI81007.1 - 7.3e-38 129.3 1.4 1.4e-37 128.4 0.9 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 CDI81007.1 - 5.6e-18 64.6 0.1 1.4e-17 63.4 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Macoilin PF09726.4 CDI81009.1 - 0.22 9.7 6.5 0.35 9.0 4.5 1.2 1 0 0 1 1 1 0 Transmembrane protein Pex14_N PF04695.8 CDI81009.1 - 0.47 10.4 9.0 2.6 8.1 5.2 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Period_C PF12114.3 CDI81009.1 - 1 8.9 13.2 0.18 11.4 5.3 2.3 3 0 0 3 3 3 0 Period protein 2/3C-terminal region SR-25 PF10500.4 CDI81009.1 - 1.7 8.0 19.6 0.59 9.5 4.6 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PAM2 PF07145.10 CDI81011.1 - 0.0014 18.0 1.5 0.0014 18.0 1.0 2.0 2 1 0 2 2 2 1 Ataxin-2 C-terminal region DUF605 PF04652.11 CDI81011.1 - 0.8 9.0 9.1 0.8 9.0 6.3 1.0 1 0 0 1 1 1 0 Vta1 like Pex14_N PF04695.8 CDI81011.1 - 1.5 8.8 5.8 1.7 8.6 4.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Protamine_P2 PF00841.14 CDI81011.1 - 1.8 9.2 4.9 2.2 8.8 3.4 1.1 1 0 0 1 1 1 0 Sperm histone P2 YajC PF02699.10 CDI81011.1 - 8.7 6.1 6.8 13 5.5 4.7 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit AhpC-TSA PF00578.16 CDI81013.1 - 2.8e-31 107.7 0.0 3.6e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CDI81013.1 - 4.3e-12 45.7 0.0 5.6e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 CDI81013.1 - 5.7e-09 35.4 0.1 9.4e-09 34.7 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.1 CDI81013.1 - 0.00075 19.4 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme PspB PF06667.7 CDI81014.1 - 0.32 10.9 1.4 0.62 10.0 1.0 1.5 1 0 0 1 1 1 0 Phage shock protein B TFIIA PF03153.8 CDI81014.1 - 2.9 7.7 30.9 4.3 7.1 4.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Actin PF00022.14 CDI81015.1 - 3.7e-12 45.3 0.2 8.2e-11 40.9 0.1 2.5 1 1 0 1 1 1 1 Actin Herpes_UL87 PF03043.9 CDI81015.1 - 0.00028 19.4 3.4 0.00078 17.9 2.4 1.5 1 1 0 1 1 1 1 Herpesvirus UL87 family SAGA-Tad1 PF12767.2 CDI81015.1 - 0.71 9.4 48.0 0.36 10.4 4.5 3.1 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit GAGA_bind PF06217.7 CDI81015.1 - 2.9 7.7 35.1 0.25 11.2 2.8 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family eIF-3_zeta PF05091.7 CDI81015.1 - 9.4 4.7 37.4 1.4 7.4 13.7 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Thioredoxin PF00085.15 CDI81018.1 - 5e-56 186.7 4.8 7.4e-31 105.9 0.3 3.5 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.1 CDI81018.1 - 2e-31 109.2 6.0 1.1e-17 64.4 0.2 3.4 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 CDI81018.1 - 2.2e-12 47.1 4.1 4e-05 23.7 0.2 4.6 3 2 0 3 3 3 2 Thioredoxin-like domain Calsequestrin PF01216.12 CDI81018.1 - 7.3e-12 44.7 0.6 1.5e-11 43.7 0.3 1.6 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_8 PF13905.1 CDI81018.1 - 1.2e-11 44.5 0.6 0.00015 21.8 0.0 4.1 4 1 1 5 5 4 2 Thioredoxin-like Thioredoxin_7 PF13899.1 CDI81018.1 - 4.7e-10 39.3 0.8 0.00013 21.8 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 CDI81018.1 - 2.2e-08 33.8 0.6 1.7e-05 24.4 0.1 2.5 2 1 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 CDI81018.1 - 9.2e-07 28.5 0.8 0.0017 17.9 0.0 2.8 3 0 0 3 3 3 2 Redoxin Thioredoxin_9 PF14595.1 CDI81018.1 - 0.00011 21.7 0.1 0.17 11.4 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin TraF PF13728.1 CDI81018.1 - 0.00014 21.4 0.0 0.03 13.8 0.0 2.7 3 0 0 3 3 3 1 F plasmid transfer operon protein NMD3 PF04981.8 CDI81018.1 - 0.014 14.4 0.0 4.5 6.3 0.0 2.4 2 0 0 2 2 2 0 NMD3 family Glutaredoxin PF00462.19 CDI81018.1 - 0.017 15.1 4.2 2.1 8.4 0.0 4.0 3 1 0 3 3 3 0 Glutaredoxin AAA_PrkA PF08298.6 CDI81018.1 - 0.038 12.6 0.0 0.085 11.5 0.0 1.6 1 0 0 1 1 1 0 PrkA AAA domain DUF2016 PF09436.5 CDI81018.1 - 0.11 12.1 0.0 1.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2016) Thioredoxin_4 PF13462.1 CDI81018.1 - 0.13 12.2 3.9 4 7.4 0.2 3.8 3 2 0 3 3 3 0 Thioredoxin TerB-C PF15615.1 CDI81019.1 - 0.0074 16.5 2.6 0.011 15.9 1.8 1.2 1 0 0 1 1 1 1 TerB-C domain PAT1 PF09770.4 CDI81019.1 - 1.3 7.2 15.7 1.4 7.0 10.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2076 PF09849.4 CDI81019.1 - 2 8.4 10.6 3.2 7.7 7.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) AA_permease_N PF08403.5 CDI81020.1 - 0.14 11.5 1.8 0.45 9.8 0.0 2.9 3 0 0 3 3 3 0 Amino acid permease N-terminal OmpH PF03938.9 CDI81020.1 - 0.32 10.9 0.0 0.32 10.9 0.0 6.4 4 2 1 5 5 5 0 Outer membrane protein (OmpH-like) DUF4536 PF15055.1 CDI81022.1 - 0.026 14.6 0.0 0.048 13.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4536) DUF4576 PF15144.1 CDI81023.1 - 0.07 12.7 0.0 0.23 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Neur_chan_memb PF02932.11 CDI81023.1 - 0.15 11.8 0.0 0.15 11.8 0.0 3.8 3 2 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region RNA_Me_trans PF04252.8 CDI81024.1 - 7.8e-07 28.6 0.1 7.9e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase HWE_HK PF07536.9 CDI81024.1 - 0.014 15.8 0.0 0.016 15.6 0.0 1.1 1 0 0 1 1 1 0 HWE histidine kinase PLU-1 PF08429.6 CDI81024.1 - 0.053 12.3 0.2 0.055 12.3 0.1 1.1 1 0 0 1 1 1 0 PLU-1-like protein SSB PF00436.20 CDI81025.1 - 3.1e-31 107.3 0.0 4.5e-31 106.7 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family Form-deh_trans PF09163.6 CDI81026.1 - 0.015 14.7 0.1 0.045 13.2 0.1 1.9 1 0 0 1 1 1 0 Formate dehydrogenase N, transmembrane DUF4357 PF14267.1 CDI81026.1 - 0.19 11.3 0.2 0.19 11.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) CLPTM1 PF05602.7 CDI81031.1 - 1.6e-43 149.0 2.9 4e-41 141.1 2.0 2.3 1 1 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) S1 PF00575.18 CDI81032.1 - 1.7e-11 44.0 0.1 2.2e-11 43.6 0.1 1.1 1 0 0 1 1 1 1 S1 RNA binding domain EcKinase PF02958.15 CDI81032.1 - 0.031 13.4 0.0 0.034 13.3 0.0 1.0 1 0 0 1 1 1 0 Ecdysteroid kinase EXOSC1 PF10447.4 CDI81032.1 - 0.046 13.6 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 Exosome component EXOSC1/CSL4 MutS_V PF00488.16 CDI81034.1 - 8e-20 71.2 0.0 2.7e-12 46.6 0.0 2.3 2 0 0 2 2 2 2 MutS domain V AAA_29 PF13555.1 CDI81034.1 - 0.0019 17.7 0.0 0.0045 16.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 CDI81034.1 - 0.0036 17.3 0.0 0.016 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDI81034.1 - 0.0042 17.2 0.0 0.062 13.4 0.0 2.4 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.22 CDI81034.1 - 0.01 16.1 1.3 0.06 13.6 0.9 2.2 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 CDI81034.1 - 0.015 15.2 0.2 0.06 13.3 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.1 CDI81034.1 - 0.017 15.4 0.1 0.092 13.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.8 CDI81034.1 - 0.055 12.3 0.0 0.098 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SMC_N PF02463.14 CDI81034.1 - 0.069 12.3 0.3 0.15 11.2 0.2 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.13 CDI81034.1 - 0.078 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.1 CDI81034.1 - 0.089 12.6 1.3 1.1 9.0 0.3 2.5 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.9 CDI81034.1 - 0.15 11.8 0.6 1.9 8.2 0.4 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TPR_11 PF13414.1 CDI81035.1 - 4.2e-07 29.5 19.7 1.8e-05 24.2 1.3 9.2 7 3 2 10 10 10 4 TPR repeat TPR_19 PF14559.1 CDI81035.1 - 1.1e-05 25.6 0.1 1.1e-05 25.6 0.1 11.7 6 3 7 13 13 13 6 Tetratricopeptide repeat TPR_16 PF13432.1 CDI81035.1 - 0.00035 21.1 5.2 0.00035 21.1 3.6 12.2 9 2 5 14 14 14 6 Tetratricopeptide repeat TPR_1 PF00515.23 CDI81035.1 - 0.00064 19.2 26.5 0.67 9.6 0.0 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 CDI81035.1 - 0.0028 17.4 0.4 0.0028 17.4 0.3 10.9 9 2 3 12 12 12 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI81035.1 - 0.0029 18.1 9.5 0.0095 16.4 2.0 16.1 13 3 4 17 17 17 6 Tetratricopeptide repeat DUF2150 PF09920.4 CDI81035.1 - 0.0062 16.1 2.5 0.043 13.3 0.8 2.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2150) TPR_8 PF13181.1 CDI81035.1 - 0.014 15.1 25.5 8.4 6.4 0.1 8.8 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDI81035.1 - 0.061 13.2 0.1 0.061 13.2 0.1 12.8 13 0 0 13 13 13 0 Tetratricopeptide repeat Mem_trans PF03547.13 CDI81035.1 - 0.088 11.0 8.8 0.022 13.0 1.9 2.2 2 0 0 2 2 2 0 Membrane transport protein TRAP_alpha PF03896.11 CDI81040.1 - 0.0012 17.9 0.9 0.0012 17.9 0.6 5.6 3 1 0 3 3 3 2 Translocon-associated protein (TRAP), alpha subunit MIP-T3 PF10243.4 CDI81040.1 - 0.0015 17.0 9.8 0.0015 17.0 6.8 4.2 4 0 0 4 4 4 2 Microtubule-binding protein MIP-T3 SPX PF03105.14 CDI81040.1 - 0.16 11.7 0.0 0.16 11.7 0.0 5.1 3 3 0 4 4 4 0 SPX domain Peptidase_A17 PF05380.8 CDI81041.1 - 0.51 10.1 0.0 0.51 10.1 0.0 3.4 3 0 0 3 3 3 0 Pao retrotransposon peptidase PCI PF01399.22 CDI81042.1 - 0.0024 18.1 0.0 2.7 8.3 0.0 2.3 2 0 0 2 2 2 2 PCI domain tRNA-synt_2d PF01409.15 CDI81044.1 - 2.2e-77 259.6 0.0 2.5e-77 259.4 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 CDI81044.1 - 2.4e-05 23.3 0.1 3.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 CDI81044.1 - 8.2e-05 22.2 0.1 0.00015 21.4 0.1 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) OapA PF04225.7 CDI81044.1 - 0.12 12.3 0.1 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 Opacity-associated protein A LysM-like domain ING PF12998.2 CDI81048.1 - 1.2e-05 25.5 2.3 1.2e-05 25.5 1.6 3.0 2 1 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PAT1 PF09770.4 CDI81048.1 - 0.0085 14.3 56.2 0.011 13.9 39.0 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Ofd1_CTDD PF10637.4 CDI81048.1 - 7.1 5.6 10.9 12 4.9 7.5 1.3 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term CoA_binding PF02629.14 CDI81049.1 - 1.7e-19 70.1 0.4 5.1e-19 68.5 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 CDI81049.1 - 4.2e-10 39.4 0.1 8.1e-08 32.0 0.0 2.2 1 1 1 2 2 2 2 CoA-ligase Succ_CoA_lig PF13607.1 CDI81049.1 - 8.2e-05 22.2 0.3 0.00048 19.7 0.0 2.1 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 CDI81049.1 - 0.00063 19.8 0.4 0.0038 17.3 0.0 2.2 2 1 0 2 2 2 1 CoA binding domain MAM PF00629.18 CDI81051.1 - 6.7e-12 45.4 14.2 2.9e-06 27.1 0.0 3.7 2 1 1 3 3 3 2 MAM domain CDK2AP PF09806.4 CDI81051.1 - 0.00091 19.5 15.2 0.00091 19.5 10.5 2.4 2 0 0 2 2 2 1 Cyclin-dependent kinase 2-associated protein SR-25 PF10500.4 CDI81051.1 - 0.15 11.5 31.2 2.2 7.6 21.6 2.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Cgr1 PF03879.9 CDI81051.1 - 2.1 8.5 14.1 0.02 15.0 1.7 2.3 2 0 0 2 2 2 0 Cgr1 family DNA_methylase PF00145.12 CDI81051.1 - 3.2 6.7 12.9 5.5 6.0 8.9 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Med15 PF09606.5 CDI81053.1 - 0.049 11.8 49.1 0.11 10.6 28.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SNN_cytoplasm PF09051.5 CDI81053.1 - 0.089 12.5 0.1 21 4.9 0.0 2.6 2 0 0 2 2 2 0 Stannin cytoplasmic Ribosomal_L6e PF01159.14 CDI81053.1 - 0.18 12.0 8.6 0.5 10.6 6.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L6e Peptidase_U57 PF05582.7 CDI81053.1 - 2.3 7.1 6.3 4 6.3 4.4 1.3 1 0 0 1 1 1 0 YabG peptidase U57 DUF4175 PF13779.1 CDI81053.1 - 8.6 3.9 43.3 0.18 9.4 23.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) AP2 PF00847.15 CDI81054.1 - 1.2e-10 41.3 4.6 1.2e-10 41.3 3.2 2.5 3 0 0 3 3 3 1 AP2 domain DUF4463 PF14703.1 CDI81054.1 - 2 8.9 3.3 9.3 6.8 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4463) Isy1 PF06246.7 CDI81056.1 - 8.2e-66 222.0 1.7 9.7e-66 221.7 1.2 1.0 1 0 0 1 1 1 1 Isy1-like splicing family Siva PF05458.7 CDI81056.1 - 0.39 10.2 4.0 0.6 9.6 2.7 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) ASFV_J13L PF05568.6 CDI81056.1 - 1.5 8.3 9.9 2.3 7.6 6.9 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DEAD PF00270.24 CDI81059.1 - 6.5e-22 77.8 3.6 1e-13 51.1 0.4 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI81059.1 - 3.3e-20 71.7 0.0 3.3e-20 71.7 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CDI81059.1 - 1.2e-15 56.7 0.0 2.7e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Ribosomal_60s PF00428.14 CDI81059.1 - 0.0032 17.8 6.6 0.0032 17.8 4.6 8.7 6 2 2 8 8 8 2 60s Acidic ribosomal protein AAA_22 PF13401.1 CDI81059.1 - 0.044 13.9 0.0 2.5 8.2 0.1 3.1 3 0 0 3 3 3 0 AAA domain DUF3801 PF12687.2 CDI81062.1 - 0.043 13.3 16.6 0.057 12.9 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Med15 PF09606.5 CDI81062.1 - 0.2 9.8 50.1 0.23 9.6 34.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CDC45 PF02724.9 CDI81062.1 - 1.7 6.5 14.8 1.9 6.4 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein PAT1 PF09770.4 CDI81062.1 - 3.1 5.9 40.8 3.2 5.8 28.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 U1snRNP70_N PF12220.3 CDI81062.1 - 9.7 6.5 18.6 9.5 6.6 4.2 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal vATP-synt_AC39 PF01992.11 CDI81063.1 - 2.4e-16 59.8 0.0 4.1e-14 52.4 0.1 2.0 1 1 1 2 2 2 2 ATP synthase (C/AC39) subunit ETRAMP PF09716.5 CDI81064.1 - 0.0091 15.9 0.0 0.017 15.0 0.0 1.4 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF3843 PF12954.2 CDI81064.1 - 0.032 13.2 0.4 0.035 13.1 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3843) BLVR PF06375.6 CDI81064.1 - 0.034 13.9 6.7 0.04 13.7 4.6 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) ExbD PF02472.11 CDI81064.1 - 0.12 12.3 0.2 0.14 12.1 0.2 1.2 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR Mgr1 PF08602.5 CDI81064.1 - 0.28 10.1 1.5 0.34 9.8 1.0 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit SAE2 PF08573.5 CDI81064.1 - 1.2 9.9 5.6 1.6 9.4 3.9 1.2 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF4337 PF14235.1 CDI81064.1 - 1.3 8.8 6.3 1.7 8.4 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Peptidase_S49_N PF08496.5 CDI81064.1 - 2.1 8.1 7.1 2.8 7.7 4.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MIP-T3 PF10243.4 CDI81065.1 - 0.0006 18.4 24.1 0.00075 18.0 16.7 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Hid1 PF12722.2 CDI81065.1 - 1.1 6.8 20.2 1.3 6.6 14.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PAT1 PF09770.4 CDI81065.1 - 1.3 7.2 41.2 1.6 6.8 28.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PLRV_ORF5 PF01690.12 CDI81065.1 - 2.3 7.2 20.0 2.7 7.0 13.8 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein FLO_LFY PF01698.11 CDI81065.1 - 7.2 5.3 27.8 0.66 8.7 16.2 1.4 2 0 0 2 2 2 0 Floricaula / Leafy protein YL1 PF05764.8 CDI81065.1 - 7.8 6.0 39.3 0.25 10.8 21.9 1.9 2 0 0 2 2 2 0 YL1 nuclear protein CATSPERG PF15064.1 CDI81066.1 - 0.0025 15.6 0.0 0.0028 15.4 0.0 1.0 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit gamma CRAL_TRIO PF00650.15 CDI81067.1 - 2.4e-26 92.1 0.0 3.4e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 CDI81067.1 - 0.00054 19.8 0.0 0.00089 19.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Coprogen_oxidas PF01218.13 CDI81075.1 - 5.8e-94 313.9 0.0 1.8e-81 272.9 0.0 2.2 2 0 0 2 2 2 2 Coproporphyrinogen III oxidase DUF853 PF05872.7 CDI81075.1 - 0.17 10.1 0.4 0.28 9.4 0.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Macoilin PF09726.4 CDI81075.1 - 7.4 4.7 11.8 0.65 8.2 3.2 1.9 2 0 0 2 2 2 0 Transmembrane protein DUF4613 PF15390.1 CDI81076.1 - 0.21 9.7 12.2 0.31 9.1 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) PAT1 PF09770.4 CDI81076.1 - 0.85 7.7 40.0 1.8 6.6 27.7 1.5 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_UL87 PF03043.9 CDI81076.1 - 2.7 6.2 7.5 4.1 5.6 5.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family Med15 PF09606.5 CDI81078.1 - 0.00032 19.0 46.8 0.00032 19.0 32.5 2.0 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Exonuc_VII_L PF02601.10 CDI81078.1 - 0.003 16.8 2.4 0.003 16.8 1.7 1.8 2 0 0 2 2 2 1 Exonuclease VII, large subunit PAT1 PF09770.4 CDI81078.1 - 0.69 8.0 32.3 0.88 7.7 22.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.1 CDI81078.1 - 1.2 9.3 10.9 1.7 8.9 7.6 1.3 1 0 0 1 1 1 0 AAA domain DUF4207 PF13904.1 CDI81078.1 - 1.5 8.1 27.4 0.012 15.0 13.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Macoilin PF09726.4 CDI81078.1 - 4.3 5.5 21.3 6.7 4.8 14.8 1.2 1 0 0 1 1 1 0 Transmembrane protein PNMA PF14893.1 CDI81078.1 - 5.2 5.9 13.5 7.7 5.4 9.3 1.2 1 0 0 1 1 1 0 PNMA Dynamin_N PF00350.18 CDI81081.1 - 0.095 12.5 0.2 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 Dynamin family Macoilin PF09726.4 CDI81081.1 - 0.26 9.5 2.5 0.29 9.3 1.8 1.0 1 0 0 1 1 1 0 Transmembrane protein Adaptin_binding PF10199.4 CDI81082.1 - 1.7e-06 28.3 0.7 1.7e-06 28.3 0.5 3.2 1 1 2 3 3 3 1 Alpha and gamma adaptin binding protein p34 tRNA-synt_2d PF01409.15 CDI81083.1 - 7.2e-31 107.2 4.6 2.5e-13 49.7 0.1 4.2 5 0 0 5 5 5 3 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 CDI81083.1 - 2.7e-17 62.7 0.0 2.7e-17 62.7 0.0 2.6 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain Dehydrin PF00257.14 CDI81083.1 - 6.9e-06 26.4 26.9 0.027 14.7 5.9 3.9 4 1 0 4 4 4 3 Dehydrin Macoilin PF09726.4 CDI81086.1 - 0.00081 17.8 21.2 0.00081 17.8 14.7 3.0 3 0 0 3 3 3 2 Transmembrane protein FimP PF09766.4 CDI81086.1 - 1.1 8.2 12.0 0.026 13.5 3.8 1.5 2 0 0 2 2 2 0 Fms-interacting protein Pkinase PF00069.20 CDI81087.1 - 1.9e-77 259.9 0.0 3.2e-77 259.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI81087.1 - 8.2e-34 116.8 0.0 1.7e-33 115.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase EF-hand_1 PF00036.27 CDI81087.1 - 2.5e-29 98.3 10.7 8.2e-08 31.0 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDI81087.1 - 9.1e-26 89.7 4.8 7.2e-13 48.4 0.9 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI81087.1 - 5.9e-23 78.6 6.5 1.4e-06 27.7 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 CDI81087.1 - 2.1e-22 77.3 9.2 3.3e-08 32.5 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 CDI81087.1 - 8.9e-22 76.4 13.0 5.9e-09 35.4 2.9 4.4 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.2 CDI81087.1 - 9.2e-08 31.7 0.8 0.0028 17.3 0.2 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 CDI81087.1 - 2.7e-06 27.1 0.6 0.0075 16.1 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain Kinase-like PF14531.1 CDI81087.1 - 0.00051 19.0 0.0 0.0028 16.6 0.0 2.0 1 1 1 2 2 2 1 Kinase-like SPARC_Ca_bdg PF10591.4 CDI81087.1 - 0.001 19.0 0.2 1.8 8.6 0.1 2.8 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region ABC1 PF03109.11 CDI81087.1 - 0.031 14.2 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 ABC1 family APH PF01636.18 CDI81087.1 - 0.034 13.8 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family TerB PF05099.8 CDI81087.1 - 0.074 12.7 0.1 0.56 9.9 0.0 2.1 1 1 1 2 2 2 0 Tellurite resistance protein TerB VCBS PF13517.1 CDI81087.1 - 0.078 13.3 0.6 14 6.1 0.3 2.9 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF1103 PF06513.6 CDI81087.1 - 0.26 10.6 1.1 0.42 9.9 0.8 1.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Xpo1 PF08389.7 CDI81088.1 - 0.027 14.3 0.1 0.19 11.6 0.0 2.4 2 1 1 3 3 3 0 Exportin 1-like protein Euplotes_phero PF05842.6 CDI81092.1 - 0.018 15.3 3.8 0.1 12.9 0.6 2.2 2 0 0 2 2 2 0 Euplotes octocarinatus mating pheromone protein Med15_fungi PF05397.7 CDI81101.1 - 0.056 13.4 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 15 Pep3_Vps18 PF05131.9 CDI81104.1 - 5.1e-06 25.9 0.0 4.3e-05 22.9 0.0 2.3 2 1 0 2 2 2 1 Pep3/Vps18/deep orange family SecG PF03840.9 CDI81104.1 - 0.14 11.9 0.7 1.2 8.9 0.0 2.8 2 0 0 2 2 2 0 Preprotein translocase SecG subunit Ku PF02735.11 CDI81108.1 - 5.1e-15 55.4 0.0 1.7e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.6 CDI81108.1 - 2.8e-12 46.5 14.7 1e-05 25.4 0.0 4.6 4 0 0 4 4 4 3 Ku C terminal domain like Activator_LAG-3 PF11498.3 CDI81108.1 - 0.002 16.9 3.4 0.002 16.9 2.4 5.4 5 0 0 5 5 5 2 Transcriptional activator LAG-3 Med15 PF09606.5 CDI81109.1 - 0.0047 15.2 23.1 0.005 15.1 16.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal FCP1_C PF09309.5 CDI81109.1 - 0.11 11.8 4.5 0.16 11.2 3.1 1.4 1 0 0 1 1 1 0 FCP1, C-terminal FAM117 PF15388.1 CDI81109.1 - 0.13 11.4 9.1 0.15 11.2 6.3 1.3 1 0 0 1 1 1 0 Protein Family FAM117 DUF4557 PF15101.1 CDI81109.1 - 0.21 11.4 9.5 0.23 11.3 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Peptidase_C58 PF03543.9 CDI81109.1 - 0.36 10.2 11.0 0.45 9.9 7.6 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen FliD_N PF02465.13 CDI81109.1 - 0.63 10.4 16.5 1.2 9.5 11.4 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus CDK5_activator PF03261.10 CDI81109.1 - 1.2 8.4 8.1 1.2 8.4 5.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein MCPVI PF02993.9 CDI81109.1 - 1.2 9.1 12.2 1.4 8.9 8.2 1.3 1 1 0 1 1 1 0 Minor capsid protein VI BAF1_ABF1 PF04684.8 CDI81109.1 - 1.3 7.7 27.3 0.53 9.0 17.5 1.3 1 1 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Suf PF05843.9 CDI81109.1 - 1.5 8.4 7.1 1.6 8.3 5.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF775 PF05603.7 CDI81109.1 - 1.7 8.1 12.4 2 7.9 8.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF775) SpaB_C PF14028.1 CDI81109.1 - 1.8 8.0 16.7 2.1 7.8 11.6 1.1 1 0 0 1 1 1 0 SpaB C-terminal domain DDHD PF02862.12 CDI81109.1 - 1.8 8.2 6.3 1.8 8.2 4.3 1.1 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.2 CDI81109.1 - 2.2 5.8 5.4 2.2 5.8 3.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rtf2 PF04641.7 CDI81109.1 - 2.6 7.1 9.6 3.2 6.8 6.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger PAT1 PF09770.4 CDI81109.1 - 3.4 5.7 24.2 3.9 5.6 16.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DivIC PF04977.10 CDI81109.1 - 5.5 6.5 10.5 8.1 6.0 7.3 1.2 1 0 0 1 1 1 0 Septum formation initiator EPSP_synthase PF00275.15 CDI81110.1 - 9.6e-31 106.6 7.3 4.5e-06 25.3 0.0 8.5 8 1 1 9 9 9 7 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 CDI81110.1 - 7.7e-24 84.0 0.1 7.7e-24 84.0 0.1 3.0 3 0 0 3 3 3 2 3-dehydroquinate synthase DUF1635 PF07795.6 CDI81111.1 - 2.7e-07 30.1 0.1 2.7e-07 30.1 0.1 6.8 1 1 6 7 7 7 1 Protein of unknown function (DUF1635) ABC_tran PF00005.22 CDI81112.1 - 4.2e-19 69.2 1.0 1.2e-18 67.6 0.0 2.4 3 0 0 3 3 2 1 ABC transporter ABC_membrane PF00664.18 CDI81112.1 - 4e-18 65.7 1.2 7.5e-18 64.9 0.9 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SbcCD_C PF13558.1 CDI81112.1 - 5.3e-06 26.2 0.2 2.1e-05 24.3 0.1 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 CDI81112.1 - 0.0003 20.8 0.3 0.0003 20.8 0.2 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.1 CDI81112.1 - 0.00071 19.0 0.0 0.0016 17.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 CDI81112.1 - 0.00095 19.2 0.0 0.092 12.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.1 CDI81112.1 - 0.0033 18.2 0.0 0.0067 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CDI81112.1 - 0.027 13.8 0.0 0.07 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDI81112.1 - 0.042 14.1 0.0 0.089 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CDI81112.1 - 0.082 13.0 0.8 0.53 10.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.1 CDI81112.1 - 0.09 12.6 1.8 3.9 7.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain Med15 PF09606.5 CDI81112.1 - 0.18 9.9 23.4 0.12 10.5 2.1 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_23 PF13476.1 CDI81112.1 - 1.3 9.3 0.0 1.3 9.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain APC_CDC26 PF10471.4 CDI81112.1 - 7.2 7.4 18.8 2.2 9.0 6.4 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 DDRGK PF09756.4 CDI81114.1 - 1.7e-39 135.1 18.8 1.7e-39 135.1 13.0 2.2 1 1 1 2 2 2 1 DDRGK domain Peptidase_S64 PF08192.6 CDI81114.1 - 0.28 9.4 1.8 0.33 9.2 1.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.4 CDI81114.1 - 0.71 9.5 14.3 1.1 8.9 9.9 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF3123 PF11321.3 CDI81114.1 - 4.8 7.4 8.0 8.8 6.6 5.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) DUF2782 PF11191.3 CDI81114.1 - 6.9 6.7 8.1 3.2 7.7 3.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2782) Draxin PF15550.1 CDI81114.1 - 9.2 5.8 13.3 13 5.3 9.2 1.1 1 0 0 1 1 1 0 Draxin Fez1 PF06818.10 CDI81114.1 - 9.3 6.2 30.9 3.9 7.4 19.4 1.8 1 1 1 2 2 2 0 Fez1 Rpp20 PF12328.3 CDI81115.1 - 0.046 13.3 0.2 0.046 13.3 0.2 1.6 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Suf PF05843.9 CDI81115.1 - 0.41 10.3 11.4 0.036 13.7 1.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) AAA_23 PF13476.1 CDI81115.1 - 5.2 7.3 9.3 2.9 8.1 2.0 2.1 2 0 0 2 2 2 0 AAA domain Thioredoxin PF00085.15 CDI81123.1 - 4.7e-13 48.7 0.0 5.9e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.1 CDI81123.1 - 0.00017 21.1 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 CDI81123.1 - 0.0015 18.1 0.5 0.003 17.1 0.2 1.6 1 1 1 2 2 2 1 Redoxin Thioredoxin_8 PF13905.1 CDI81123.1 - 0.0036 17.3 0.0 0.0065 16.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 CDI81123.1 - 0.053 13.7 0.2 3 8.0 0.1 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain DUF605 PF04652.11 CDI81124.1 - 0.055 12.8 43.5 0.078 12.3 30.2 1.1 1 0 0 1 1 1 0 Vta1 like GAGA_bind PF06217.7 CDI81124.1 - 0.21 11.4 30.0 0.032 14.1 16.5 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Herpes_UL87 PF03043.9 CDI81124.1 - 0.28 9.5 10.9 0.36 9.1 7.5 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family DUF853 PF05872.7 CDI81124.1 - 1.6 7.0 20.9 3 6.0 14.5 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Vfa1 PF08432.5 CDI81124.1 - 2.3 8.2 40.0 0.069 13.1 20.7 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Mem_trans PF03547.13 CDI81124.1 - 3.4 5.8 14.2 0.014 13.6 3.9 1.4 2 0 0 2 2 2 0 Membrane transport protein HemX PF04375.9 CDI81124.1 - 3.9 5.9 46.8 0.021 13.4 24.8 2.1 1 1 0 2 2 2 0 HemX SAGA-Tad1 PF12767.2 CDI81124.1 - 4.3 6.9 35.8 0.12 12.0 19.8 1.9 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Raftlin PF15250.1 CDI81124.1 - 6.2 5.2 33.0 0.81 8.1 18.9 1.9 2 0 0 2 2 2 0 Raftlin CDC45 PF02724.9 CDI81124.1 - 8.9 4.2 40.0 0.063 11.3 21.6 1.7 2 0 0 2 2 2 0 CDC45-like protein HSP20 PF00011.16 CDI81128.1 - 0.018 14.9 0.0 0.018 14.9 0.0 2.1 2 0 0 2 2 2 0 Hsp20/alpha crystallin family AAA_23 PF13476.1 CDI81128.1 - 0.027 14.7 21.4 0.23 11.7 7.2 2.4 2 0 0 2 2 2 0 AAA domain FCP1_C PF09309.5 CDI81128.1 - 0.048 12.9 21.9 0.026 13.8 2.6 3.2 3 0 0 3 3 3 0 FCP1, C-terminal UPF0180 PF03698.8 CDI81128.1 - 1.1 9.1 10.6 2.5 7.9 0.2 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0180) Suf PF05843.9 CDI81128.1 - 1.2 8.8 25.1 0.025 14.3 3.8 2.5 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDI81128.1 - 1.2 7.2 54.0 0.058 11.6 14.9 3.0 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 ABC2_membrane_3 PF12698.2 CDI81128.1 - 3 6.8 8.6 6.4 5.7 0.4 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Dala_Dala_lig_N PF01820.16 CDI81128.1 - 3.9 7.8 8.5 4.5 7.6 1.2 2.5 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus Pro_CA PF00484.14 CDI81128.1 - 7.4 6.5 7.2 0.7 9.8 0.8 2.0 2 0 0 2 2 2 0 Carbonic anhydrase Peptidase_S49_N PF08496.5 CDI81128.1 - 7.9 6.2 15.4 2.4 7.9 4.5 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Cob_adeno_trans PF01923.13 CDI81128.1 - 9.3 6.0 15.0 4.7 6.9 5.0 2.3 2 0 0 2 2 2 0 Cobalamin adenosyltransferase DUF342 PF03961.8 CDI81128.1 - 9.5 4.5 14.3 0.4 9.0 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) WD40 PF00400.27 CDI81132.1 - 0.013 15.3 4.1 3.3 7.7 0.0 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat CAF-1_p150 PF11600.3 CDI81133.1 - 0.074 12.4 0.6 0.5 9.7 0.1 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Collagen PF01391.13 CDI81134.1 - 0.00032 20.1 34.0 0.00032 20.1 23.6 2.5 2 1 0 2 2 2 1 Collagen triple helix repeat (20 copies) MCPVI PF02993.9 CDI81134.1 - 0.0012 19.1 7.4 0.0012 19.1 5.1 4.2 3 1 1 4 4 4 1 Minor capsid protein VI SAPS PF04499.10 CDI81134.1 - 0.02 13.5 0.2 0.02 13.5 0.1 2.7 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein Exonuc_VII_L PF02601.10 CDI81134.1 - 0.11 11.6 44.6 0.91 8.6 5.1 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF572 PF04502.8 CDI81134.1 - 2.4 7.2 67.9 0.85 8.7 28.4 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF572) Sof1 PF04158.9 CDI81138.1 - 3.3e-29 100.7 13.4 4.6e-29 100.2 9.3 1.2 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.27 CDI81138.1 - 8.5e-15 53.9 8.4 9.5e-06 25.3 0.2 6.0 5 1 1 6 6 6 3 WD domain, G-beta repeat Glt_symporter PF03616.9 CDI81139.1 - 0.0041 15.6 0.4 0.0041 15.6 0.3 2.0 1 1 0 1 1 1 1 Sodium/glutamate symporter AAA_23 PF13476.1 CDI81139.1 - 3.7 7.8 24.7 0.16 12.2 1.1 3.2 3 0 0 3 3 3 0 AAA domain CAF-1_p150 PF11600.3 CDI81141.1 - 0.033 13.5 21.4 0.042 13.2 14.8 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Utp14 PF04615.8 CDI81141.1 - 0.23 9.5 15.6 0.28 9.2 10.8 1.0 1 0 0 1 1 1 0 Utp14 protein Cellulose_synt PF03552.9 CDI81141.1 - 0.91 7.7 9.2 1.1 7.5 6.4 1.2 1 0 0 1 1 1 0 Cellulose synthase DUF4011 PF13195.1 CDI81141.1 - 2.4 8.1 8.6 3 7.8 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) DUF4175 PF13779.1 CDI81141.1 - 3.2 5.3 48.0 3.6 5.1 33.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AAA_23 PF13476.1 CDI81141.1 - 5.2 7.3 22.5 6.1 7.1 15.6 1.1 1 0 0 1 1 1 0 AAA domain Slu7 PF11708.3 CDI81141.1 - 6.1 6.5 17.2 7.2 6.2 11.9 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor FLO_LFY PF01698.11 CDI81141.1 - 6.1 5.5 17.1 7.5 5.2 11.8 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein MRP-S31 PF15433.1 CDI81141.1 - 6.9 6.0 21.8 7.9 5.7 15.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 AUX_IAA PF02309.11 CDI81141.1 - 9.1 5.9 16.1 13 5.5 11.2 1.2 1 0 0 1 1 1 0 AUX/IAA family TFIIA PF03153.8 CDI81141.1 - 9.4 6.0 35.5 12 5.6 24.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 60KD_IMP PF02096.15 CDI81142.1 - 0.0064 16.1 0.9 0.0064 16.1 0.6 2.2 2 0 0 2 2 2 1 60Kd inner membrane protein Nop53 PF07767.6 CDI81142.1 - 7.4 5.4 23.9 1.3 7.9 10.0 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) ELMO_CED12 PF04727.8 CDI81143.1 - 2.1e-24 85.9 0.6 8.6e-24 83.9 0.0 2.0 1 1 0 2 2 2 1 ELMO/CED-12 family FimP PF09766.4 CDI81143.1 - 1.3 8.0 27.4 0.088 11.8 8.5 2.4 2 0 0 2 2 2 0 Fms-interacting protein Herpes_BLLF1 PF05109.8 CDI81144.1 - 0.12 10.3 23.4 0.16 9.9 16.2 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Macoilin PF09726.4 CDI81144.1 - 0.47 8.6 37.7 1.7 6.8 26.1 1.7 1 1 0 1 1 1 0 Transmembrane protein eIF-3_zeta PF05091.7 CDI81144.1 - 2.2 6.7 19.6 4.3 5.8 13.6 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SAGA-Tad1 PF12767.2 CDI81144.1 - 7 6.2 21.4 18 4.8 14.8 1.6 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Pex16 PF08610.5 CDI81144.1 - 9.5 5.1 15.6 18 4.1 10.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) PP2C PF00481.16 CDI81145.1 - 2.2e-33 115.7 0.0 1.6e-29 103.1 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 CDI81145.1 - 0.0043 16.4 1.0 1.2 8.4 0.3 2.6 2 1 0 2 2 2 2 Protein phosphatase 2C Med15 PF09606.5 CDI81146.1 - 0.026 12.7 43.8 0.04 12.1 30.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MelC1 PF06236.6 CDI81146.1 - 0.037 13.9 1.7 0.037 13.9 1.2 3.3 2 1 0 2 2 2 0 Tyrosinase co-factor MelC1 RED_N PF07808.8 CDI81146.1 - 0.3 10.2 11.6 0.6 9.2 8.0 1.4 1 0 0 1 1 1 0 RED-like protein N-terminal region Kin17_mid PF10357.4 CDI81146.1 - 0.59 9.7 8.6 0.039 13.6 1.7 2.0 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein FimP PF09766.4 CDI81146.1 - 1.3 8.0 13.6 0.034 13.2 3.6 2.0 2 0 0 2 2 2 0 Fms-interacting protein eIF3g PF12353.3 CDI81146.1 - 1.5 8.7 11.3 4.8 7.1 0.1 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G Secretin_N_2 PF07655.8 CDI81146.1 - 3.3 8.1 30.9 5.9 7.3 2.8 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain DUF3801 PF12687.2 CDI81146.1 - 8.1 5.9 11.0 10 5.6 4.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) ABC_tran PF00005.22 CDI81147.1 - 1.8e-27 96.3 0.0 4.7e-18 65.7 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CDI81147.1 - 1e-11 45.3 1.4 0.0038 17.2 0.4 3.3 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 CDI81147.1 - 3e-09 36.2 0.2 0.0024 17.3 0.1 2.3 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4 PF00037.22 CDI81147.1 - 1.9e-07 30.3 3.7 3.5e-07 29.5 2.5 1.5 1 0 0 1 1 1 1 4Fe-4S binding domain SMC_N PF02463.14 CDI81147.1 - 3.6e-07 29.6 0.4 0.074 12.2 0.0 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_33 PF13671.1 CDI81147.1 - 1.3e-06 28.2 0.4 0.028 14.2 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDI81147.1 - 2.9e-06 27.4 0.1 0.05 13.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 CDI81147.1 - 3.9e-06 27.6 0.8 0.016 16.0 0.3 2.9 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 CDI81147.1 - 5.1e-06 26.9 0.1 0.0023 18.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CDI81147.1 - 5.7e-06 26.5 0.2 0.026 14.7 0.1 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.1 CDI81147.1 - 6e-06 25.5 0.0 0.17 10.9 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain Fer4_6 PF12837.2 CDI81147.1 - 1.4e-05 24.7 2.9 3.2e-05 23.5 2.0 1.6 1 0 0 1 1 1 1 4Fe-4S binding domain AAA_18 PF13238.1 CDI81147.1 - 1.6e-05 25.2 0.1 0.0034 17.6 0.0 2.7 3 0 0 3 3 2 1 AAA domain MobB PF03205.9 CDI81147.1 - 2.4e-05 24.0 0.2 0.27 10.9 0.0 2.4 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 CDI81147.1 - 2.6e-05 23.4 0.0 0.021 14.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 CDI81147.1 - 4.8e-05 23.8 0.0 0.022 15.2 0.0 2.7 3 0 0 3 3 2 1 Miro-like protein AAA_16 PF13191.1 CDI81147.1 - 8.7e-05 22.5 0.0 0.3 11.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.7 CDI81147.1 - 9.2e-05 22.1 0.5 0.048 13.3 0.0 2.4 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.17 CDI81147.1 - 0.00012 22.1 0.0 1.2 9.3 0.0 2.9 3 0 0 3 3 3 2 RNA helicase AAA_25 PF13481.1 CDI81147.1 - 0.00015 21.2 0.1 0.48 9.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.9 CDI81147.1 - 0.00016 21.3 0.4 0.47 10.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 CDI81147.1 - 0.00019 21.4 0.0 0.44 10.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.17 CDI81147.1 - 0.00021 20.7 0.7 0.6 9.5 0.0 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain Rad17 PF03215.10 CDI81147.1 - 0.00027 19.7 0.0 0.037 12.7 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Fer4_7 PF12838.2 CDI81147.1 - 0.00037 20.8 3.8 0.00045 20.5 1.1 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 CDI81147.1 - 0.00043 20.0 2.6 0.00043 20.0 1.8 1.6 2 0 0 2 2 1 1 4Fe-4S dicluster domain UPF0079 PF02367.12 CDI81147.1 - 0.00046 19.7 0.0 0.23 11.0 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Fer4_2 PF12797.2 CDI81147.1 - 0.00052 19.7 2.7 0.0013 18.4 1.9 1.7 1 0 0 1 1 1 1 4Fe-4S binding domain Thymidylate_kin PF02223.12 CDI81147.1 - 0.0007 19.0 0.1 0.33 10.3 0.0 3.1 3 0 0 3 3 3 1 Thymidylate kinase AAA_30 PF13604.1 CDI81147.1 - 0.0012 18.4 0.1 1.1 8.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.1 CDI81147.1 - 0.0023 17.6 1.0 0.0049 16.6 0.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 CDI81147.1 - 0.0025 18.0 1.8 0.0025 18.0 1.3 2.0 2 0 0 2 2 1 1 4Fe-4S dicluster domain DUF815 PF05673.8 CDI81147.1 - 0.0026 16.7 0.3 2.1 7.2 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_14 PF13173.1 CDI81147.1 - 0.0034 17.2 0.1 3.5 7.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain VirE PF05272.6 CDI81147.1 - 0.0035 16.8 0.3 1.8 7.9 0.0 2.6 3 0 0 3 3 2 1 Virulence-associated protein E Fer4_3 PF12798.2 CDI81147.1 - 0.0037 17.7 4.3 0.011 16.2 3.0 1.8 1 0 0 1 1 1 1 4Fe-4S binding domain FtsK_SpoIIIE PF01580.13 CDI81147.1 - 0.01 15.3 0.1 3.9 6.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_19 PF13245.1 CDI81147.1 - 0.012 15.3 0.2 3.4 7.4 0.0 2.7 3 0 0 3 3 2 0 Part of AAA domain ArgK PF03308.11 CDI81147.1 - 0.012 14.4 0.1 0.55 8.9 0.0 2.1 2 0 0 2 2 2 0 ArgK protein Fer4_18 PF13746.1 CDI81147.1 - 0.013 15.9 0.6 0.028 14.8 0.4 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain TrwB_AAD_bind PF10412.4 CDI81147.1 - 0.016 13.8 0.0 0.92 8.0 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.18 CDI81147.1 - 0.017 15.1 0.6 1.9 8.4 0.0 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase Mg_chelatase PF01078.16 CDI81147.1 - 0.017 14.3 0.0 0.27 10.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Fer4_16 PF13484.1 CDI81147.1 - 0.018 15.7 2.1 0.043 14.5 1.5 1.6 1 0 0 1 1 1 0 4Fe-4S double cluster binding domain AAA_13 PF13166.1 CDI81147.1 - 0.025 13.0 3.6 0.42 9.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain Fer4_8 PF13183.1 CDI81147.1 - 0.026 14.5 0.7 0.053 13.5 0.5 1.4 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_15 PF13459.1 CDI81147.1 - 0.043 14.3 1.0 0.11 13.1 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S single cluster domain Zeta_toxin PF06414.7 CDI81147.1 - 0.05 12.7 0.5 2.6 7.0 0.0 2.7 3 0 0 3 3 3 0 Zeta toxin G-alpha PF00503.15 CDI81147.1 - 0.057 12.0 0.1 0.34 9.5 0.0 2.0 2 1 0 2 2 2 0 G-protein alpha subunit Fer4_17 PF13534.1 CDI81147.1 - 0.08 13.2 1.5 0.2 12.0 1.0 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain MutS_V PF00488.16 CDI81147.1 - 0.084 12.2 0.1 1.4 8.2 0.0 2.1 2 0 0 2 2 2 0 MutS domain V AAA_10 PF12846.2 CDI81147.1 - 0.13 11.7 2.0 5.2 6.4 0.0 2.5 3 0 0 3 3 2 0 AAA-like domain T2SE PF00437.15 CDI81147.1 - 0.17 10.7 0.0 12 4.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.1 CDI81147.1 - 0.21 11.1 1.5 4.2 6.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain Fer4_4 PF12800.2 CDI81147.1 - 0.6 10.6 7.4 0.077 13.3 1.9 1.9 2 0 0 2 2 1 0 4Fe-4S binding domain Dynamin_N PF00350.18 CDI81147.1 - 0.61 9.8 2.2 2.2 8.0 0.0 2.4 3 0 0 3 3 2 0 Dynamin family DUF87 PF01935.12 CDI81147.1 - 2.8 7.7 6.1 17 5.1 0.4 3.0 3 1 1 4 4 3 0 Domain of unknown function DUF87 AAA_23 PF13476.1 CDI81151.1 - 0.059 13.6 5.3 0.18 12.1 3.7 1.9 1 0 0 1 1 1 0 AAA domain Med22 PF06179.7 CDI81152.1 - 0.0025 17.8 0.1 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Sds3 PF08598.6 CDI81152.1 - 0.037 13.5 0.1 0.049 13.1 0.1 1.1 1 0 0 1 1 1 0 Sds3-like Trypsin_2 PF13365.1 CDI81156.1 - 1.6e-07 31.3 0.7 0.0054 16.7 0.0 2.6 1 1 1 2 2 2 2 Trypsin-like peptidase domain PDZ PF00595.19 CDI81156.1 - 5.7e-05 23.2 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 CDI81156.1 - 0.00014 21.6 0.0 0.00031 20.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Trypsin PF00089.21 CDI81156.1 - 0.14 11.7 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Trypsin Dpy-30 PF05186.8 CDI81157.1 - 3.4e-06 26.4 0.1 7.6e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 Dpy-30 motif IQ PF00612.22 CDI81159.1 - 0.016 14.8 0.2 0.06 13.0 0.1 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF1825 PF08855.5 CDI81159.1 - 0.45 10.5 12.9 0.024 14.6 2.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF1825) GAS PF13851.1 CDI81159.1 - 9.9 5.2 35.2 14 4.8 5.4 3.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.7 CDI81168.1 - 0.13 12.4 3.9 1.2 9.4 0.0 3.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Phage_GPO PF05929.6 CDI81168.1 - 0.14 11.4 4.2 0.099 11.8 1.0 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4349 PF14257.1 CDI81170.1 - 0.036 13.3 0.0 0.036 13.3 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) Pkinase PF00069.20 CDI81171.1 - 1.5e-36 125.8 0.0 1.8e-36 125.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI81171.1 - 3.9e-16 58.8 0.0 4.8e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CDI81171.1 - 0.047 12.4 0.1 0.074 11.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3626 PF12294.3 CDI81172.1 - 3.1e-06 26.4 0.0 4.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3626) Gln-synt_N PF03951.14 CDI81173.1 - 0.091 12.3 0.2 2.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain Sedlin_N PF04628.8 CDI81177.1 - 1.3e-06 28.3 0.0 1.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Presenilin PF01080.12 CDI81177.1 - 8.3 5.1 10.4 12 4.5 7.2 1.2 1 0 0 1 1 1 0 Presenilin DnaJ PF00226.26 CDI81179.1 - 0.0089 15.7 0.0 0.041 13.6 0.0 2.1 1 0 0 1 1 1 1 DnaJ domain PAT1 PF09770.4 CDI81179.1 - 1.6 6.8 58.8 0.026 12.7 24.3 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 THRAP3_BCLAF1 PF15440.1 CDI81179.1 - 5 5.6 34.3 0.034 12.8 15.5 2.0 2 0 0 2 2 2 0 THRAP3/BCLAF1 family KCNQC3-Ank-G_bd PF11956.3 CDI81186.1 - 0.018 15.0 1.5 0.081 12.9 0.1 2.5 2 0 0 2 2 2 0 Ankyrin-G binding motif of KCNQ2-3 MSP1_C PF07462.6 CDI81187.1 - 0.052 11.9 8.8 0.096 11.0 5.7 1.7 1 1 1 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus DUF3413 PF11893.3 CDI81188.1 - 0.0084 15.0 0.7 0.012 14.4 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3413) Activator_LAG-3 PF11498.3 CDI81188.1 - 0.0097 14.7 13.9 0.011 14.5 9.7 1.2 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Med15 PF09606.5 CDI81188.1 - 0.013 13.7 13.5 0.017 13.3 9.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Pep_M12B_propep PF01562.14 CDI81188.1 - 0.031 14.0 0.1 0.048 13.4 0.1 1.3 1 0 0 1 1 1 0 Reprolysin family propeptide SurA_N PF09312.6 CDI81188.1 - 0.32 10.8 8.1 0.53 10.1 5.6 1.3 1 0 0 1 1 1 0 SurA N-terminal domain PhageMin_Tail PF10145.4 CDI81188.1 - 2.7 7.5 0.0 2.7 7.5 0.0 2.5 2 1 0 2 2 2 0 Phage-related minor tail protein T2SF PF00482.18 CDI81188.1 - 5.2 7.0 7.3 9.3 6.1 3.2 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF4589 PF15252.1 CDI81189.1 - 0.027 14.2 6.5 0.034 13.9 4.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) Baculo_p33 PF05214.7 CDI81189.1 - 1.1 8.4 7.7 1.1 8.4 5.3 1.1 1 0 0 1 1 1 0 Baculovirus P33 Med15 PF09606.5 CDI81189.1 - 1.5 6.9 49.1 1.4 7.0 34.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI81189.1 - 1.5 6.9 34.2 1.4 7.0 23.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4355 PF14265.1 CDI81189.1 - 2.4 8.1 24.1 2.8 7.8 16.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) G0-G1_switch_2 PF15103.1 CDI81189.1 - 2.5 8.3 12.3 3.8 7.7 8.5 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 Baculo_PP31 PF05311.6 CDI81189.1 - 2.5 7.2 16.2 2.8 7.1 11.2 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Cellulose_synt PF03552.9 CDI81189.1 - 3 6.0 8.3 2.9 6.0 5.8 1.0 1 0 0 1 1 1 0 Cellulose synthase AAA_11 PF13086.1 CDI81189.1 - 3.4 7.1 15.7 3.5 7.1 10.9 1.1 1 0 0 1 1 1 0 AAA domain DUF4175 PF13779.1 CDI81189.1 - 3.5 5.2 39.0 3.3 5.2 27.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AAA_23 PF13476.1 CDI81189.1 - 3.6 7.8 23.0 3.8 7.7 16.0 1.1 1 0 0 1 1 1 0 AAA domain Serinc PF03348.10 CDI81189.1 - 3.8 6.1 13.1 4.2 5.9 9.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_U57 PF05582.7 CDI81189.1 - 3.8 6.3 12.9 3.9 6.3 9.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 AIF_C PF14721.1 CDI81189.1 - 4 7.6 10.1 4.4 7.5 7.0 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pex14_N PF04695.8 CDI81189.1 - 4.2 7.4 18.3 5 7.1 12.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BTV_NS2 PF04514.7 CDI81189.1 - 4.7 5.9 13.9 5 5.9 9.6 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 SprA-related PF12118.3 CDI81189.1 - 6.2 6.0 34.7 6.8 5.9 24.0 1.1 1 0 0 1 1 1 0 SprA-related family FemAB PF02388.11 CDI81189.1 - 6.4 5.3 17.6 6.3 5.3 12.2 1.0 1 0 0 1 1 1 0 FemAB family Hid1 PF12722.2 CDI81189.1 - 6.6 4.2 13.8 6.7 4.2 9.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dala_Dala_lig_N PF01820.16 CDI81189.1 - 6.9 7.0 7.4 8.1 6.7 5.1 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus DUF3381 PF11861.3 CDI81189.1 - 9.8 5.6 18.4 11 5.5 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF4557 PF15101.1 CDI81189.1 - 9.9 5.9 26.9 11 5.8 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) AP2 PF00847.15 CDI81190.1 - 3.4e-19 68.7 2.7 4.5e-11 42.7 0.4 5.2 6 0 0 6 6 6 2 AP2 domain SPX PF03105.14 CDI81190.1 - 1.2e-06 28.5 15.2 0.0017 18.2 1.8 2.5 2 0 0 2 2 2 2 SPX domain DUF1700 PF08006.6 CDI81192.1 - 0.041 13.1 3.6 0.059 12.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) SNF PF00209.13 CDI81193.1 - 0.57 8.5 0.0 1.6 7.1 0.0 1.7 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family AP2 PF00847.15 CDI81195.1 - 1.2e-07 31.7 2.0 1.2e-07 31.7 1.4 4.4 6 0 0 6 6 6 1 AP2 domain DUF4129 PF13559.1 CDI81197.1 - 0.032 14.1 0.1 0.061 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Abhydro_lipase PF04083.11 CDI81200.1 - 5.6e-05 22.4 0.1 0.00075 18.8 0.1 2.5 1 1 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Haem_bd PF14376.1 CDI81201.1 - 1.5e-05 24.7 0.1 0.21 11.2 0.0 3.1 3 0 0 3 3 3 2 Haem-binding domain Apolipo_F PF15148.1 CDI81201.1 - 0.073 12.3 0.4 13 5.0 0.0 2.5 2 0 0 2 2 2 0 Apolipoprotein F Tir_receptor_M PF03549.9 CDI81201.1 - 0.15 12.1 0.0 31 4.7 0.0 2.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) intimin-binding domain Orthopox_C10L PF07020.6 CDI81203.1 - 0.11 12.9 0.8 0.2 12.2 0.1 1.7 2 0 0 2 2 2 0 Orthopoxvirus C10L protein Atg14 PF10186.4 CDI81203.1 - 1.9 7.3 6.8 2.5 6.9 4.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1675 PF07897.6 CDI81203.1 - 5.4 6.7 9.7 6.7 6.4 6.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1675) CDC45 PF02724.9 CDI81203.1 - 5.6 4.8 9.9 7.1 4.5 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M14 PF00246.19 CDI81204.1 - 8.9e-07 28.7 0.0 0.0078 15.8 0.0 2.9 2 1 0 2 2 2 2 Zinc carboxypeptidase DUF1643 PF07799.7 CDI81204.1 - 0.013 15.1 0.7 4.8 6.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1643) Mmp37 PF09139.6 CDI81204.1 - 0.96 8.4 5.4 8.5 5.2 0.2 2.4 2 0 0 2 2 2 0 Mitochondrial matrix Mmp37 EF-hand_7 PF13499.1 CDI81205.1 - 7.5e-13 48.4 2.9 1.6e-12 47.3 2.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair COPI_assoc PF08507.5 CDI81205.1 - 1.4e-12 47.5 0.1 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 COPI associated protein EF-hand_8 PF13833.1 CDI81205.1 - 1.5e-12 46.8 1.4 3.9e-12 45.5 1.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI81205.1 - 1.4e-10 39.6 3.1 2.1e-06 26.6 0.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 CDI81205.1 - 1.7e-10 39.8 1.6 4.3e-05 23.0 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 CDI81205.1 - 1.1e-09 37.2 4.1 1.5e-06 27.2 0.5 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 CDI81205.1 - 9.6e-07 28.8 2.6 1.9e-06 27.8 1.8 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 CDI81205.1 - 0.039 13.6 0.9 0.083 12.5 0.2 1.9 2 0 0 2 2 2 0 EF hand Pox_I5 PF04713.7 CDI81205.1 - 0.097 12.3 0.4 0.97 9.1 0.0 2.2 2 0 0 2 2 2 0 Poxvirus protein I5 EF-hand_4 PF12763.2 CDI81205.1 - 0.14 11.9 0.4 0.28 10.9 0.3 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF3488 PF11992.3 CDI81205.1 - 1.9 7.0 6.6 2.6 6.6 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) Spore_coat_CotO PF14153.1 CDI81206.1 - 8 5.8 9.4 8.7 5.7 6.5 1.0 1 0 0 1 1 1 0 Spore coat protein CotO DEDD_Tnp_IS110 PF01548.12 CDI81208.1 - 2.6 7.7 7.9 2.6 7.6 4.1 2.1 1 1 1 2 2 2 0 Transposase DUF2217 PF10265.4 CDI81208.1 - 4.3 5.9 7.8 3.1 6.4 2.3 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2217) Vasculin PF15337.1 CDI81210.1 - 0.082 13.3 0.2 0.082 13.3 0.2 4.3 3 1 1 4 4 4 0 Vascular protein family Vasculin-like 1 Nup54 PF13874.1 CDI81214.1 - 0.00011 21.8 0.2 0.00011 21.8 0.1 3.9 2 1 1 3 3 3 1 Nucleoporin complex subunit 54 HTH_30 PF13556.1 CDI81214.1 - 0.022 14.3 0.1 0.099 12.2 0.1 2.1 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain MACPF PF01823.14 CDI81214.1 - 0.1 12.2 3.5 0.36 10.4 0.2 2.3 2 1 0 2 2 2 0 MAC/Perforin domain Unstab_antitox PF09720.5 CDI81214.1 - 0.33 10.6 4.3 0.41 10.3 0.1 3.0 3 0 0 3 3 3 0 Putative addiction module component BBP1_C PF15272.1 CDI81214.1 - 1.3 8.4 16.1 0.45 10.0 0.2 2.5 2 1 0 2 2 2 0 Spindle pole body component BBP1, C-terminal ApoO PF09769.4 CDI81215.1 - 0.13 11.9 7.7 0.4 10.3 0.2 4.0 3 2 1 4 4 4 0 Apolipoprotein O Thiolase_N PF00108.18 CDI81216.1 - 8e-53 179.1 0.0 1.8e-28 99.2 0.0 3.1 3 0 0 3 3 3 3 Thiolase, N-terminal domain Thiolase_C PF02803.13 CDI81216.1 - 6.2e-23 80.5 2.2 8.2e-23 80.1 0.1 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 CDI81216.1 - 3.2e-07 30.1 8.8 1.5e-05 24.5 4.0 3.2 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 CDI81216.1 - 1.2e-05 24.8 2.4 0.059 13.0 0.0 3.1 3 0 0 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1719 PF08224.6 CDI81217.1 - 0.079 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) RAP PF08373.5 CDI81221.1 - 0.0002 21.0 0.0 0.00045 19.9 0.0 1.7 1 0 0 1 1 1 1 RAP domain GATA PF00320.22 CDI81223.1 - 6e-08 31.9 3.9 1.2e-07 30.9 2.7 1.6 1 0 0 1 1 1 1 GATA zinc finger AMP-binding PF00501.23 CDI81224.1 - 1.1e-84 284.2 0.0 1.5e-84 283.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CDI81224.1 - 1.5e-20 73.8 1.0 3.1e-20 72.9 0.7 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DNA_pol_viral_N PF00242.12 CDI81226.1 - 0.82 8.6 10.5 1.6 7.6 7.3 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain SRP-alpha_N PF04086.8 CDI81226.1 - 1.4 8.2 6.5 2.5 7.4 4.5 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2638 PF10937.3 CDI81226.1 - 1.6 9.7 8.4 6.4 7.8 5.8 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2638) UMPH-1 PF05822.7 CDI81227.1 - 0.09 12.0 0.0 0.31 10.3 0.0 1.8 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) Ribosomal_L7Ae PF01248.21 CDI81229.1 - 4.1e-28 96.7 0.6 5.2e-28 96.4 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.7 CDI81229.1 - 0.0082 16.2 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding CAP PF00188.21 CDI81232.1 - 0.0011 19.5 0.0 0.0018 18.7 0.0 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family p450 PF00067.17 CDI81232.1 - 0.075 11.5 0.0 0.1 11.1 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 EnY2 PF10163.4 CDI81233.1 - 0.00096 19.0 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Transcription factor e(y)2 AAA_23 PF13476.1 CDI81237.1 - 0.0098 16.2 1.3 0.011 16.0 0.9 1.2 1 0 0 1 1 1 1 AAA domain Y2_Tnp PF04986.8 CDI81237.1 - 0.022 14.5 2.0 0.045 13.4 1.4 1.4 1 0 0 1 1 1 0 Putative transposase DUF3588 PF12140.3 CDI81237.1 - 0.17 11.9 3.7 0.4 10.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3588) RAB3GAP2_N PF14655.1 CDI81237.1 - 0.94 8.4 10.4 0.42 9.5 3.9 2.2 2 1 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Med15 PF09606.5 CDI81237.1 - 2 6.5 26.3 3.3 5.8 18.2 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3886 PF13025.1 CDI81237.1 - 2.9 7.9 18.1 1.9 8.4 10.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) Exonuc_VII_L PF02601.10 CDI81237.1 - 3.5 6.7 10.8 0.74 8.9 5.3 1.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF1151 PF06625.6 CDI81237.1 - 6.3 6.5 17.6 3.4 7.4 10.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) PAT1 PF09770.4 CDI81237.1 - 8.5 4.4 22.1 11 4.1 15.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 fn2 PF00040.14 CDI81241.1 - 0.0085 16.0 1.0 0.021 14.8 0.6 1.7 1 1 0 1 1 1 1 Fibronectin type II domain DUF1510 PF07423.6 CDI81242.1 - 1.7 7.9 22.2 1.8 7.9 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Rtf2 PF04641.7 CDI81242.1 - 2.6 7.2 22.4 2.6 7.1 15.5 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger NARP1 PF12569.3 CDI81242.1 - 3.4 6.3 20.8 3.5 6.2 14.4 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GAGA_bind PF06217.7 CDI81242.1 - 5.9 6.7 25.3 6.4 6.6 17.5 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.12 CDI81242.1 - 8.6 6.0 20.2 11 5.7 14.0 1.3 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.8 CDI81243.1 - 3.4 6.1 5.3 3.9 5.8 3.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GTP_EFTU PF00009.22 CDI81244.1 - 2.9e-31 108.3 3.9 9.7e-31 106.6 0.0 2.7 1 1 1 2 2 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI81244.1 - 0.0014 18.6 0.0 0.0039 17.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SprA-related PF12118.3 CDI81244.1 - 0.032 13.5 53.5 0.015 14.6 22.6 2.1 2 0 0 2 2 2 0 SprA-related family CobT PF06213.7 CDI81244.1 - 0.062 12.4 26.1 0.058 12.5 9.0 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF853 PF05872.7 CDI81244.1 - 0.18 10.0 8.5 0.23 9.7 5.9 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) NARP1 PF12569.3 CDI81244.1 - 0.47 9.1 16.8 0.62 8.7 11.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Zip PF02535.17 CDI81244.1 - 0.54 9.2 15.4 0.43 9.5 4.8 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter OmpH PF03938.9 CDI81244.1 - 0.93 9.4 34.8 1.4 8.8 24.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) VSG_B PF13206.1 CDI81244.1 - 0.95 8.5 15.3 1.8 7.6 10.6 1.4 1 0 0 1 1 1 0 Trypanosomal VSG domain Peptidase_S49_N PF08496.5 CDI81244.1 - 1 9.1 13.9 1.7 8.4 9.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Borrelia_P83 PF05262.6 CDI81244.1 - 1.9 6.6 17.1 2.2 6.4 11.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3807 PF12720.2 CDI81244.1 - 2 8.5 27.4 3.3 7.8 13.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF2201_N PF13203.1 CDI81244.1 - 2.6 7.1 26.9 0.98 8.5 9.5 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain CKAP2_C PF15297.1 CDI81244.1 - 3.4 6.3 24.6 1.2 7.8 12.4 2.0 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus DDHD PF02862.12 CDI81244.1 - 3.8 7.2 31.7 1.6 8.4 9.1 2.1 2 0 0 2 2 2 0 DDHD domain eIF-3_zeta PF05091.7 CDI81244.1 - 3.8 6.0 20.3 5.6 5.4 14.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1180 PF06679.7 CDI81244.1 - 4.5 7.1 7.2 9.2 6.1 5.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Peptidase_U57 PF05582.7 CDI81244.1 - 4.6 6.1 12.3 6.5 5.6 8.6 1.2 1 0 0 1 1 1 0 YabG peptidase U57 PAT1 PF09770.4 CDI81244.1 - 5.4 5.1 36.7 8.7 4.4 25.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI81244.1 - 5.9 4.4 18.0 8.5 3.9 12.5 1.2 1 0 0 1 1 1 0 Ycf1 Raftlin PF15250.1 CDI81244.1 - 6.1 5.2 29.5 1.7 7.0 10.4 2.0 2 0 0 2 2 2 0 Raftlin FLO_LFY PF01698.11 CDI81244.1 - 8.2 5.1 21.2 1.1 8.0 9.5 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein CDC45 PF02724.9 CDI81244.1 - 9.6 4.0 30.8 4.5 5.2 3.5 2.1 2 0 0 2 2 2 0 CDC45-like protein Med15 PF09606.5 CDI81248.1 - 0.0056 14.9 60.9 0.0062 14.8 42.2 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Ribosomal_60s PF00428.14 CDI81248.1 - 0.17 12.3 20.7 0.41 11.0 0.8 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein PAT1 PF09770.4 CDI81248.1 - 0.94 7.6 48.9 0.97 7.5 33.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Shadoo PF14999.1 CDI81248.1 - 2 8.2 15.2 0.56 10.0 5.1 2.1 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective GAGA_bind PF06217.7 CDI81248.1 - 2.3 8.0 14.3 3.3 7.5 9.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4045 PF13254.1 CDI81248.1 - 6.2 5.9 14.2 7.1 5.7 9.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Spt20 PF12090.3 CDI81252.1 - 0.024 13.9 0.4 0.024 13.9 0.3 3.4 2 1 0 2 2 2 0 Spt20 family Herpes_UL87 PF03043.9 CDI81252.1 - 0.046 12.0 0.0 1.5 7.1 0.0 2.1 1 1 0 2 2 2 0 Herpesvirus UL87 family PAT1 PF09770.4 CDI81252.1 - 0.52 8.4 45.6 0.024 12.8 8.3 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 FLO_LFY PF01698.11 CDI81252.1 - 7.6 5.2 14.8 0.16 10.8 0.1 2.7 3 0 0 3 3 3 0 Floricaula / Leafy protein Sugar_tr PF00083.19 CDI81255.1 - 1.5e-40 139.1 23.9 9.3e-37 126.6 16.5 3.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDI81255.1 - 2.9e-13 49.2 51.1 7.3e-12 44.6 35.4 3.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Ycf1 PF05758.7 CDI81255.1 - 0.0075 14.0 1.9 0.013 13.2 0.0 1.8 2 0 0 2 2 2 1 Ycf1 Sporozoite_P67 PF05642.6 CDI81255.1 - 0.015 13.1 0.2 0.034 12.0 0.1 1.5 1 1 0 1 1 1 0 Sporozoite P67 surface antigen DUF2407_C PF13373.1 CDI81255.1 - 0.027 14.3 0.1 0.027 14.3 0.1 2.6 3 0 0 3 3 3 0 DUF2407 C-terminal domain PRTase_1 PF11202.3 CDI81255.1 - 0.11 11.5 2.5 0.2 10.6 1.7 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) DUF3513 PF12026.3 CDI81255.1 - 0.22 11.0 16.6 0.14 11.6 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3513) DUF3573 PF12097.3 CDI81255.1 - 0.68 8.4 11.3 0.45 9.0 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) DUF1681 PF07933.9 CDI81255.1 - 1.4 8.5 3.9 0.82 9.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1681) PSI_PsaF PF02507.10 CDI81255.1 - 3.6 7.1 5.2 1.9 8.0 0.3 2.4 2 0 0 2 2 2 0 Photosystem I reaction centre subunit III Dus PF01207.12 CDI81256.1 - 2.4e-13 49.6 20.3 1.7e-08 33.6 8.6 4.3 2 2 1 3 3 3 2 Dihydrouridine synthase (Dus) DUF506 PF04720.7 CDI81256.1 - 0.0061 16.2 3.4 0.0061 16.2 2.4 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF506) Herpes_UL87 PF03043.9 CDI81256.1 - 0.28 9.5 12.0 0.31 9.3 1.0 2.3 2 0 0 2 2 2 0 Herpesvirus UL87 family RAB3GAP2_N PF14655.1 CDI81256.1 - 3.2 6.6 25.9 0.054 12.4 2.7 3.7 4 0 0 4 4 4 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PAP1 PF08601.5 CDI81256.1 - 4 7.0 39.2 0.26 10.9 11.1 3.5 3 0 0 3 3 3 0 Transcription factor PAP1 eIF3g PF12353.3 CDI81256.1 - 8.9 6.2 9.6 2.6 7.9 1.4 2.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Nop14 PF04147.7 CDI81257.1 - 9.7e-15 53.5 69.7 9.7e-15 53.5 48.3 6.8 5 1 0 5 5 5 3 Nop14-like family Dehydrin PF00257.14 CDI81257.1 - 0.0027 18.0 4.9 0.0027 18.0 3.4 8.2 6 3 1 7 7 7 1 Dehydrin RNA_pol_A_bac PF01000.21 CDI81258.1 - 2.8e-08 33.9 0.0 1.2e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 CDI81258.1 - 0.00062 18.8 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Peptidase_S49_N PF08496.5 CDI81258.1 - 1.2 8.9 0.0 1.2 8.9 0.0 4.4 4 1 0 4 4 4 0 Peptidase family S49 N-terminal Hid1 PF12722.2 CDI81258.1 - 5.8 4.4 35.8 1.6 6.3 7.7 3.3 3 0 0 3 3 3 0 High-temperature-induced dauer-formation protein HhH-GPD PF00730.20 CDI81259.1 - 1.1e-19 70.7 0.0 1.1e-19 70.7 0.0 2.0 2 1 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 CDI81259.1 - 3.2e-06 26.5 0.0 6.9e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Activator_LAG-3 PF11498.3 CDI81261.1 - 0.0028 16.4 41.9 0.0063 15.3 10.7 2.2 2 0 0 2 2 2 2 Transcriptional activator LAG-3 bZIP_C PF12498.3 CDI81261.1 - 0.065 14.4 1.2 0.065 14.4 0.9 2.3 1 1 1 2 2 2 0 Basic leucine-zipper C terminal Med15 PF09606.5 CDI81261.1 - 0.9 7.6 36.5 1.1 7.3 25.3 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peptidase_S15 PF02129.13 CDI81261.1 - 2.1 7.6 17.3 0.074 12.4 2.6 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Choline_kinase PF01633.15 CDI81262.1 - 1.9e-39 135.4 0.0 1.2e-38 132.8 0.0 2.2 3 0 0 3 3 3 1 Choline/ethanolamine kinase APH PF01636.18 CDI81262.1 - 3.4e-17 62.9 0.7 3.4e-17 62.9 0.5 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family EcKinase PF02958.15 CDI81262.1 - 6.5e-05 22.2 0.1 6.5e-05 22.2 0.1 2.5 2 1 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.6 CDI81262.1 - 0.0019 16.9 0.4 0.013 14.1 0.0 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1679) E_Pc_C PF06752.7 CDI81262.1 - 0.67 9.4 41.6 0.051 13.0 6.5 3.2 3 0 0 3 3 3 0 Enhancer of Polycomb C-terminus Helicase_C PF00271.26 CDI81263.1 - 6.7e-05 22.6 0.0 0.00021 21.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribosomal_60s PF00428.14 CDI81263.1 - 1.5 9.3 17.7 0.29 11.5 0.4 3.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein Iso_dh PF00180.15 CDI81264.1 - 7.3e-68 229.0 0.0 8.8e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNA_pol_viral_N PF00242.12 CDI81265.1 - 0.56 9.1 19.7 0.71 8.8 13.7 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain GAGA_bind PF06217.7 CDI81265.1 - 1.2 9.0 15.8 1.5 8.7 11.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Ycf1 PF05758.7 CDI81265.1 - 1.5 6.4 13.9 1.6 6.3 9.6 1.1 1 0 0 1 1 1 0 Ycf1 TFIIA PF03153.8 CDI81265.1 - 1.8 8.3 33.6 2.4 7.9 23.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BTV_NS2 PF04514.7 CDI81265.1 - 4.7 5.9 13.5 5.8 5.6 9.4 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 EIIBC-GUT_N PF03612.9 CDI81265.1 - 6.3 6.3 0.0 6.3 6.3 0.0 3.2 1 1 1 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus PAT1 PF09770.4 CDI81265.1 - 6.6 4.8 48.1 8.3 4.5 33.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI81267.1 - 1.5e-08 34.9 0.0 1.6e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit BAF1_ABF1 PF04684.8 CDI81268.1 - 0.0022 16.9 9.2 0.0022 16.9 6.3 3.7 4 1 0 4 4 4 1 BAF1 / ABF1 chromatin reorganising factor R3H-assoc PF13902.1 CDI81268.1 - 0.067 13.1 0.2 0.067 13.1 0.2 3.2 4 0 0 4 4 4 0 R3H-associated N-terminal domain Spt20 PF12090.3 CDI81268.1 - 0.29 10.4 7.4 1.4 8.2 0.3 2.9 3 0 0 3 3 3 0 Spt20 family Med3 PF11593.3 CDI81270.1 - 0.25 10.5 11.0 0.27 10.4 7.6 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal AP2 PF00847.15 CDI81271.1 - 2.4e-09 37.1 0.1 5.8e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 AP2 domain DUF4289 PF14121.1 CDI81271.1 - 4.1 5.7 2.1 5.9 5.1 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4289) AP2 PF00847.15 CDI81272.1 - 7.2e-09 35.6 0.0 1.4e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 AP2 domain RNA_pol_Rpc4 PF05132.9 CDI81273.1 - 1e-08 35.2 0.0 1e-08 35.2 0.0 3.3 3 2 0 3 3 3 1 RNA polymerase III RPC4 SSrecog PF03531.9 CDI81275.1 - 1.1e-51 175.3 0.1 1.9e-51 174.5 0.1 1.4 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 CDI81275.1 - 1.5e-26 92.1 1.2 2.8e-26 91.3 0.1 2.1 3 0 0 3 3 3 1 Histone chaperone Rttp106-like YL1 PF05764.8 CDI81275.1 - 0.0095 15.5 18.1 0.0095 15.5 12.6 1.7 2 0 0 2 2 2 1 YL1 nuclear protein YajC PF02699.10 CDI81278.1 - 0.0048 16.5 0.7 0.0048 16.5 0.5 3.8 4 0 0 4 4 4 1 Preprotein translocase subunit Acyl_transf_3 PF01757.17 CDI81278.1 - 0.22 10.3 1.7 0.37 9.5 1.1 1.2 1 0 0 1 1 1 0 Acyltransferase family DUF1189 PF06691.6 CDI81278.1 - 2.9 7.1 0.0 4.7 6.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Vps35 PF03635.12 CDI81279.1 - 6.8e-195 649.4 0.0 9.8e-147 490.2 0.0 2.6 2 1 0 2 2 2 2 Vacuolar protein sorting-associated protein 35 Med3 PF11593.3 CDI81279.1 - 0.43 9.7 2.8 0.85 8.7 2.0 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Prenyltrans_2 PF13249.1 CDI81279.1 - 5.7 7.3 7.0 4.2 7.8 1.4 2.8 3 0 0 3 3 3 0 Prenyltransferase-like RNA_pol_Rpb2_1 PF04563.10 CDI81280.1 - 1.1e-35 122.3 0.0 1.3e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CDI81280.1 - 5.5e-20 71.5 0.0 1e-19 70.6 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF4201 PF13870.1 CDI81281.1 - 9.3e-05 21.9 28.1 9.3e-05 21.9 19.5 4.3 4 1 0 4 4 4 2 Domain of unknown function (DUF4201) PAT1 PF09770.4 CDI81283.1 - 0.047 11.9 36.9 0.046 11.9 25.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprA-related PF12118.3 CDI81283.1 - 0.087 12.1 42.7 0.12 11.7 29.6 1.1 1 0 0 1 1 1 0 SprA-related family DUF3337 PF11816.3 CDI81283.1 - 0.14 11.5 17.8 0.16 11.3 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Med15 PF09606.5 CDI81283.1 - 1.2 7.2 50.5 1.1 7.3 35.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RR_TM4-6 PF06459.7 CDI81283.1 - 1.4 8.7 20.4 2 8.2 14.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.3 CDI81283.1 - 2.5 6.7 19.9 2.5 6.7 13.8 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 N6_N4_Mtase PF01555.13 CDI81283.1 - 3.3 7.1 11.7 3.7 6.9 8.1 1.1 1 0 0 1 1 1 0 DNA methylase FLO_LFY PF01698.11 CDI81283.1 - 3.3 6.4 23.8 3.7 6.2 16.5 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Apt1 PF10351.4 CDI81283.1 - 3.8 6.2 21.2 5.2 5.8 14.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain eIF-3_zeta PF05091.7 CDI81283.1 - 4.2 5.8 25.3 4.7 5.7 17.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_23 PF13476.1 CDI81283.1 - 5.5 7.2 22.6 6.3 7.0 15.7 1.1 1 0 0 1 1 1 0 AAA domain Raftlin PF15250.1 CDI81283.1 - 6 5.2 21.9 8 4.8 15.2 1.2 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.9 CDI81283.1 - 6.3 4.6 21.5 9.2 4.1 14.9 1.4 1 0 0 1 1 1 0 CDC45-like protein HAUS6_N PF14661.1 CDI81283.1 - 7.4 5.8 21.4 8.1 5.7 14.9 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF2072 PF09845.4 CDI81283.1 - 8.5 6.3 11.4 13 5.7 7.9 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Med15 PF09606.5 CDI81284.1 - 0.00012 20.4 86.3 0.00014 20.2 59.8 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI81284.1 - 0.23 9.6 65.0 0.25 9.5 45.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.8 CDI81284.1 - 5 6.9 49.3 6.4 6.5 34.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit KH_1 PF00013.24 CDI81287.1 - 1.4e-18 66.2 0.0 2.4e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_3 PF13014.1 CDI81287.1 - 2.8e-14 52.3 1.1 5.1e-08 32.3 0.1 2.4 2 0 0 2 2 2 2 KH domain Med15 PF09606.5 CDI81287.1 - 3.8e-07 28.7 68.2 4e-06 25.3 12.4 3.3 3 0 0 3 3 3 2 ARC105 or Med15 subunit of Mediator complex non-fungal KH_2 PF07650.12 CDI81287.1 - 0.00076 18.9 0.0 0.077 12.5 0.0 2.4 2 0 0 2 2 2 1 KH domain KH_4 PF13083.1 CDI81287.1 - 0.004 16.7 1.7 1.3 8.6 0.2 2.5 2 0 0 2 2 2 2 KH domain Activator_LAG-3 PF11498.3 CDI81287.1 - 0.0057 15.4 20.1 0.0057 15.4 13.9 3.7 4 0 0 4 4 4 1 Transcriptional activator LAG-3 DUF106 PF01956.11 CDI81287.1 - 2.4 7.6 18.1 9.9 5.6 3.1 3.3 3 0 0 3 3 3 0 Integral membrane protein DUF106 Exonuc_VII_L PF02601.10 CDI81287.1 - 2.7 7.1 30.5 0.57 9.3 9.2 3.2 3 0 0 3 3 3 0 Exonuclease VII, large subunit LMBR1 PF04791.11 CDI81287.1 - 7.1 5.0 7.6 3 6.3 0.8 2.3 2 0 0 2 2 2 0 LMBR1-like membrane protein Metallophos PF00149.23 CDI81289.1 - 3.2e-28 98.4 0.1 4.6e-28 97.9 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDI81289.1 - 0.067 13.0 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Isochorismatase PF00857.15 CDI81290.1 - 3e-12 46.8 0.0 4.9e-12 46.1 0.0 1.4 1 1 0 1 1 1 1 Isochorismatase family ABC_tran PF00005.22 CDI81291.1 - 4e-21 75.7 0.0 5.3e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 CDI81291.1 - 3.8e-05 23.7 0.6 4.6e-05 23.4 0.0 1.4 2 0 0 2 2 1 1 AAA ATPase domain AAA_21 PF13304.1 CDI81291.1 - 7.7e-05 22.7 0.0 0.031 14.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CDI81291.1 - 9.4e-05 21.6 0.0 0.00012 21.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 CDI81291.1 - 0.00042 20.4 0.0 0.00069 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CDI81291.1 - 0.0024 17.8 0.0 0.006 16.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.1 CDI81291.1 - 0.0025 18.1 0.1 0.0039 17.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CDI81291.1 - 0.0032 17.2 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_28 PF13521.1 CDI81291.1 - 0.0035 17.3 0.1 0.0073 16.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDI81291.1 - 0.0047 17.7 0.0 0.0062 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CDI81291.1 - 0.0077 16.1 0.0 0.013 15.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 CDI81291.1 - 0.0084 15.6 1.0 0.014 14.8 0.0 1.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 CDI81291.1 - 0.0092 15.4 0.3 0.025 14.1 0.0 1.8 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 CDI81291.1 - 0.012 15.0 0.2 0.023 14.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.10 CDI81291.1 - 0.013 14.2 0.1 0.018 13.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NACHT PF05729.7 CDI81291.1 - 0.024 14.2 0.1 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 CDI81291.1 - 0.026 14.8 0.0 0.034 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 CDI81291.1 - 0.026 13.7 0.2 0.05 12.8 0.0 1.5 2 0 0 2 2 1 0 Ferrous iron transport protein B Dynamin_N PF00350.18 CDI81291.1 - 0.032 14.0 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Dynamin family AAA_19 PF13245.1 CDI81291.1 - 0.039 13.6 4.9 0.12 12.1 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain AAA_33 PF13671.1 CDI81291.1 - 0.046 13.5 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 CDI81291.1 - 0.053 14.0 0.2 0.34 11.4 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein AAA_10 PF12846.2 CDI81291.1 - 0.06 12.7 0.1 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_24 PF13479.1 CDI81291.1 - 0.081 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 CDI81291.1 - 0.094 12.1 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.17 CDI81291.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 CDI81291.1 - 0.14 11.0 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SRPRB PF09439.5 CDI81291.1 - 0.15 11.3 0.1 0.28 10.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_35 PF14516.1 CDI81291.1 - 0.15 10.6 0.0 0.25 9.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Ribul_P_3_epim PF00834.14 CDI81291.1 - 0.15 11.1 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family ATP-synt_ab PF00006.20 CDI81291.1 - 0.16 11.4 0.0 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.17 CDI81291.1 - 0.16 12.1 0.1 0.25 11.5 0.0 1.5 1 1 0 1 1 1 0 RNA helicase DER1 PF04511.10 CDI81301.1 - 1.7e-13 50.5 0.0 3.8e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 Der1-like family Kei1 PF08552.6 CDI81301.1 - 0.11 12.1 0.1 0.11 12.1 0.0 2.3 2 1 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2865 PF11064.3 CDI81301.1 - 0.13 12.1 4.7 0.081 12.7 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2865) Apt1 PF10351.4 CDI81301.1 - 0.58 8.9 12.8 0.011 14.6 1.3 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.12 CDI81301.1 - 2.6 6.7 5.7 0.56 8.9 0.2 2.0 2 0 0 2 2 2 0 Presenilin EPL1 PF10513.4 CDI81301.1 - 3 8.0 7.1 4.7 7.4 0.7 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Thioredoxin PF00085.15 CDI81302.1 - 9.6e-45 150.5 0.3 3e-31 107.1 0.2 2.8 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 CDI81302.1 - 2.4e-11 43.7 0.0 1.8e-05 24.6 0.0 2.9 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_3 PF13192.1 CDI81302.1 - 6.1e-09 35.5 0.0 0.0049 16.6 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin domain Thioredoxin_2 PF13098.1 CDI81302.1 - 8.3e-09 35.6 2.3 0.00063 19.9 0.1 3.9 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDI81302.1 - 4.6e-08 33.0 0.1 0.01 15.9 0.0 4.2 2 2 2 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.1 CDI81302.1 - 1.2e-06 28.3 0.3 0.00037 20.4 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like TraF PF13728.1 CDI81302.1 - 0.0037 16.7 0.0 0.077 12.4 0.0 2.3 2 0 0 2 2 2 1 F plasmid transfer operon protein HyaE PF07449.6 CDI81302.1 - 0.0042 16.9 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.1 CDI81302.1 - 0.011 15.2 0.0 0.2 11.2 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin MsyB PF13984.1 CDI81302.1 - 0.025 14.6 0.0 0.06 13.3 0.0 1.6 1 0 0 1 1 1 0 MsyB protein AhpC-TSA PF00578.16 CDI81302.1 - 0.065 12.9 0.2 8.4 6.1 0.0 2.3 2 0 0 2 2 2 0 AhpC/TSA family Apolipoprotein PF01442.13 CDI81303.1 - 0.0034 16.9 9.4 0.0034 16.9 6.5 2.9 3 0 0 3 3 3 1 Apolipoprotein A1/A4/E domain NPV_P10 PF05531.7 CDI81303.1 - 0.023 14.9 2.3 1.6 9.0 1.6 3.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 CDI81303.1 - 0.034 13.9 1.2 0.18 11.5 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.13 CDI81303.1 - 0.036 13.0 2.2 0.069 12.1 1.6 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Prefoldin PF02996.12 CDI81303.1 - 0.043 13.4 6.0 0.023 14.3 2.3 1.9 2 0 0 2 2 2 0 Prefoldin subunit AAA_13 PF13166.1 CDI81303.1 - 0.044 12.2 2.3 0.076 11.4 0.6 1.8 2 0 0 2 2 2 0 AAA domain IL6 PF00489.12 CDI81303.1 - 0.14 11.7 0.6 8.3 5.9 0.3 2.4 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family DUF883 PF05957.8 CDI81303.1 - 0.21 12.0 11.0 0.056 13.8 4.3 2.6 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF883) FUSC PF04632.7 CDI81303.1 - 0.41 9.0 12.4 1.1 7.5 8.6 1.7 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-HC2 PF13490.1 CDI81303.1 - 0.46 10.4 2.9 2 8.4 2.0 2.2 1 0 0 1 1 1 0 Putative zinc-finger IncA PF04156.9 CDI81303.1 - 0.48 9.9 7.7 1.4 8.4 5.3 1.9 1 0 0 1 1 1 0 IncA protein Fib_alpha PF08702.5 CDI81303.1 - 0.78 9.8 3.0 3.7 7.6 0.7 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF848 PF05852.6 CDI81303.1 - 2.1 8.2 7.1 1.2 8.9 2.6 2.3 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Baculo_PEP_C PF04513.7 CDI81303.1 - 5.7 6.7 7.3 5 6.9 0.7 3.4 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus UBA_e1_C PF09358.5 CDI81304.1 - 0.036 14.2 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme e1 C-terminal domain GDA1_CD39 PF01150.12 CDI81307.1 - 9.8e-44 149.5 0.0 1.3e-39 136.0 0.0 2.3 2 1 0 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family LCE PF14672.1 CDI81307.1 - 7.7 7.0 13.6 3.2 8.2 6.8 2.3 2 0 0 2 2 2 0 Late cornified envelope Ribosomal_60s PF00428.14 CDI81307.1 - 8.4 6.8 43.7 0.25 11.7 1.7 4.9 5 0 0 5 5 5 0 60s Acidic ribosomal protein Titin_Z PF09042.6 CDI81310.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 Titin Z Glyoxalase_5 PF14696.1 CDI81310.1 - 0.14 12.0 0.1 2.9 7.8 0.1 2.2 2 0 0 2 2 2 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal RRM_1 PF00076.17 CDI81311.1 - 1.3e-14 53.5 0.0 2.2e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI81311.1 - 8.3e-12 44.9 0.0 1.5e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI81311.1 - 3.9e-06 26.6 0.0 5.7e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ctr PF04145.10 CDI81313.1 - 6.5e-13 48.9 2.6 8.4e-13 48.5 1.8 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF3561 PF12084.3 CDI81313.1 - 0.11 12.3 2.4 0.14 12.0 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3561) GLTP PF08718.6 CDI81314.1 - 1.6e-13 50.9 0.0 2.2e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) UQ_con PF00179.21 CDI81316.1 - 1.2e-44 151.1 0.0 1.4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDI81316.1 - 0.04 13.6 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 CDI81316.1 - 0.044 13.6 0.4 0.073 12.9 0.3 1.6 1 1 0 1 1 1 0 RWD domain SNF2_N PF00176.18 CDI81317.1 - 6.6e-50 169.6 0.5 4.7e-27 94.5 0.0 4.3 3 1 0 3 3 3 3 SNF2 family N-terminal domain Helicase_C PF00271.26 CDI81317.1 - 2.1e-13 49.9 0.0 6.5e-13 48.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 CDI81317.1 - 2.9e-08 33.4 1.6 1.2e-07 31.4 1.1 2.2 1 0 0 1 1 1 1 Ring finger domain zf-PARP PF00645.13 CDI81317.1 - 1.9e-07 31.1 0.0 8.7e-07 29.1 0.0 2.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-C3HC4_2 PF13923.1 CDI81317.1 - 0.00013 21.9 4.5 0.00025 20.9 0.8 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDI81317.1 - 0.00014 21.8 0.6 0.00047 20.1 0.4 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CDI81317.1 - 0.00044 19.8 1.8 0.00044 19.8 1.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDI81317.1 - 0.002 17.9 0.2 0.0061 16.3 0.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PyrI_C PF02748.10 CDI81317.1 - 0.019 14.3 0.1 0.054 12.9 0.1 1.7 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Reticulon PF02453.12 CDI81318.1 - 2.2e-11 43.6 7.1 3.7e-11 42.9 4.9 1.4 1 1 0 1 1 1 1 Reticulon 2TM PF13239.1 CDI81318.1 - 5.2 7.2 6.2 13 5.9 0.1 2.2 2 0 0 2 2 2 0 2TM domain UQ_con PF00179.21 CDI81320.1 - 2.1e-18 66.1 0.0 3e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDI81320.1 - 0.028 14.3 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_A PF14457.1 CDI81320.1 - 0.077 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family A CBM_48 PF02922.13 CDI81321.1 - 1.2e-19 70.1 0.0 1.2e-18 66.9 0.0 2.7 3 0 0 3 3 3 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.13 CDI81321.1 - 4.5e-19 68.3 0.0 1.7e-18 66.5 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 CDI81321.1 - 2.5e-17 63.2 0.2 2.6e-08 33.6 0.0 3.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain PDEase_I PF00233.14 CDI81322.1 - 4e-44 151.1 6.3 2e-22 80.1 3.2 2.2 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase GAF_3 PF13492.1 CDI81322.1 - 1.2e-05 25.4 0.0 0.00023 21.2 0.0 2.6 2 0 0 2 2 2 1 GAF domain RCC1_2 PF13540.1 CDI81323.1 - 1.9e-12 46.4 25.6 0.00021 20.7 0.3 5.8 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 CDI81323.1 - 2.7e-10 40.2 18.6 0.00025 21.2 1.6 7.4 8 0 0 8 8 8 3 Regulator of chromosome condensation (RCC1) repeat WD40 PF00400.27 CDI81325.1 - 3.8e-18 64.5 7.2 9.8e-08 31.6 0.1 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat EF-hand_1 PF00036.27 CDI81325.1 - 0.0033 16.6 0.0 0.0078 15.4 0.0 1.6 1 0 0 1 1 1 1 EF hand PQQ PF01011.16 CDI81325.1 - 0.28 10.7 1.8 95 2.8 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat PQQ_3 PF13570.1 CDI81325.1 - 3 8.2 6.4 8.5 6.7 0.0 4.1 5 1 0 5 5 5 0 PQQ-like domain OB_NTP_bind PF07717.11 CDI81327.1 - 5.6e-14 51.9 0.0 5.6e-14 51.9 0.0 2.9 2 1 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CDI81327.1 - 1.7e-11 43.7 0.2 1.3e-10 40.9 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.18 CDI81327.1 - 1.4e-09 37.8 0.0 1.4e-09 37.8 0.0 4.3 3 1 0 3 3 3 1 Helicase associated domain (HA2) DEAD PF00270.24 CDI81327.1 - 4.4e-08 32.7 0.2 1.5e-07 31.0 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDI81327.1 - 0.00053 20.1 2.6 0.0013 18.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.7 CDI81327.1 - 0.0021 17.7 3.1 0.0034 17.0 0.4 2.7 3 0 0 3 3 3 1 NACHT domain T2SE PF00437.15 CDI81327.1 - 0.0048 15.8 0.0 0.011 14.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.1 CDI81327.1 - 0.12 12.7 18.0 2 8.7 0.0 4.0 4 0 0 4 4 4 0 AAA domain Zip PF02535.17 CDI81329.1 - 0.00044 19.3 1.0 0.00044 19.3 0.7 10.8 10 3 1 11 11 11 2 ZIP Zinc transporter SPRY PF00622.23 CDI81329.1 - 0.44 10.6 0.1 1.6 8.8 0.0 1.9 2 0 0 2 2 2 0 SPRY domain Helicase_C PF00271.26 CDI81330.1 - 3.8e-10 39.4 0.0 3.8e-09 36.2 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.18 CDI81330.1 - 1.3e-08 34.7 0.0 1.3e-08 34.7 0.0 3.9 4 1 0 4 4 4 1 Helicase associated domain (HA2) HSP90 PF00183.13 CDI81331.1 - 3.9e-73 246.6 0.0 1.3e-70 238.3 0.0 2.7 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.1 CDI81331.1 - 3.8e-12 46.0 0.0 7.8e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDI81331.1 - 1.6e-06 27.7 0.0 3.8e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CBP4 PF07960.6 CDI81331.1 - 3.7 7.1 8.2 0.93 9.1 3.3 1.8 2 0 0 2 2 2 0 CBP4 Methyltransf_15 PF09445.5 CDI81332.1 - 4.2e-26 91.4 0.0 6.6e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 CDI81332.1 - 2e-08 34.2 2.7 1.5e-07 31.4 0.1 3.1 3 1 0 3 3 3 1 Methyltransferase domain Cons_hypoth95 PF03602.10 CDI81332.1 - 0.0018 17.7 0.0 0.0034 16.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Met_10 PF02475.11 CDI81332.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_18 PF12847.2 CDI81332.1 - 0.07 13.7 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CRAL_TRIO PF00650.15 CDI81334.1 - 0.029 13.8 0.1 0.044 13.2 0.1 1.3 1 0 0 1 1 1 0 CRAL/TRIO domain Rib_5-P_isom_A PF06026.9 CDI81334.1 - 0.14 11.4 0.0 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Med15 PF09606.5 CDI81335.1 - 0.35 9.0 79.2 0.46 8.6 54.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SOBP PF15279.1 CDI81335.1 - 1.1 9.6 24.1 1.4 9.2 16.7 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Herpes_DNAp_acc PF04929.7 CDI81335.1 - 1.1 8.1 23.2 1.7 7.5 16.0 1.4 1 1 0 1 1 1 0 Herpes DNA replication accessory factor Draxin PF15550.1 CDI81335.1 - 9.2 5.8 27.3 11 5.6 19.0 1.3 1 0 0 1 1 1 0 Draxin CTD_bind PF04818.8 CDI81339.1 - 0.037 14.2 0.4 0.087 13.0 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase II-binding domain. Macoilin PF09726.4 CDI81339.1 - 0.2 9.9 9.6 0.27 9.4 6.7 1.2 1 0 0 1 1 1 0 Transmembrane protein FCP1_C PF09309.5 CDI81339.1 - 2 7.6 16.4 1.4 8.1 5.9 2.2 2 0 0 2 2 2 0 FCP1, C-terminal DUF488 PF04343.8 CDI81340.1 - 0.84 10.0 5.8 0.25 11.7 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF488 RNase_H PF00075.19 CDI81340.1 - 1.2 9.4 11.0 1.1 9.5 3.5 2.3 2 0 0 2 2 2 0 RNase H DUF1840 PF08895.6 CDI81341.1 - 0.016 15.2 5.6 0.016 15.2 3.9 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) Herpes_UL87 PF03043.9 CDI81341.1 - 2.1 6.6 11.8 4.1 5.6 8.2 1.4 1 0 0 1 1 1 0 Herpesvirus UL87 family AAA_13 PF13166.1 CDI81341.1 - 3.9 5.8 14.0 6.6 5.0 9.7 1.2 1 0 0 1 1 1 0 AAA domain DUF3373 PF11853.3 CDI81341.1 - 8.2 4.8 11.8 1.9 6.9 5.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3373) Zein PF01559.11 CDI81342.1 - 0.0038 16.5 8.0 0.0045 16.2 5.6 1.1 1 0 0 1 1 1 1 Zein seed storage protein Cwf_Cwc_15 PF04889.7 CDI81343.1 - 1.3e-12 47.9 28.7 7.8e-10 38.8 4.8 3.3 2 1 1 3 3 3 2 Cwf15/Cwc15 cell cycle control protein DUF2948 PF11164.3 CDI81343.1 - 0.088 12.4 1.6 0.16 11.6 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2948) GET2 PF08690.5 CDI81343.1 - 0.55 9.4 7.4 0.7 9.0 5.2 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 MRP-S31 PF15433.1 CDI81343.1 - 9.8 5.4 11.9 13 5.0 8.3 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 EMP24_GP25L PF01105.19 CDI81344.1 - 0.002 17.8 0.0 0.0024 17.6 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Humanin PF15040.1 CDI81344.1 - 1.6 8.0 6.1 16 4.8 4.3 2.5 1 1 0 1 1 1 0 Humanin family Pkinase_Tyr PF07714.12 CDI81353.1 - 1.3e-05 24.4 0.0 2.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 CDI81353.1 - 0.017 14.2 0.0 0.051 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain Spt20 PF12090.3 CDI81353.1 - 0.27 10.5 6.0 0.2 10.9 0.1 2.2 2 0 0 2 2 2 0 Spt20 family Ribosomal_60s PF00428.14 CDI81353.1 - 0.34 11.3 29.9 0.024 15.0 3.7 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein Guanylate_cyc_2 PF09778.4 CDI81364.1 - 1.4e-11 44.0 0.0 1.9e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Guanylylate cyclase Peptidase_C39 PF03412.10 CDI81364.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase C39 family Rifin_STEVOR PF02009.11 CDI81364.1 - 9.2 5.8 7.2 15 5.0 5.0 1.4 1 0 0 1 1 1 0 Rifin/stevor family Pkinase PF00069.20 CDI81368.1 - 7e-06 25.3 0.0 4e-05 22.8 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI81368.1 - 9e-05 21.6 0.0 0.00098 18.2 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase AbiH PF14253.1 CDI81368.1 - 0.19 11.2 3.3 0.33 10.5 2.3 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH DUF1840 PF08895.6 CDI81368.1 - 7.9 6.5 8.0 0.72 9.8 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) V_ATPase_I PF01496.14 CDI81368.1 - 9.6 3.9 7.0 13 3.4 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF908 PF06012.7 CDI81369.1 - 2.7e-34 118.9 0.0 2.7e-34 118.9 0.0 8.2 9 1 0 9 9 9 2 Domain of Unknown Function (DUF908) UBA PF00627.26 CDI81369.1 - 5.3e-10 38.8 0.4 1.6e-09 37.2 0.3 2.0 1 0 0 1 1 1 1 UBA/TS-N domain DUF4414 PF14377.1 CDI81369.1 - 9.3e-10 38.3 4.1 1.1e-06 28.5 0.2 23.4 25 3 3 28 28 28 3 Domain of unknown function (DUF4414) DUF913 PF06025.7 CDI81369.1 - 3.5e-05 22.7 0.0 3.5e-05 22.7 0.0 16.5 20 1 1 21 21 21 3 Domain of Unknown Function (DUF913) Pox_E2-like PF04497.7 CDI81369.1 - 0.16 9.9 0.1 0.37 8.7 0.1 1.6 1 0 0 1 1 1 0 Poxviridae protein DUF2434 PF10361.4 CDI81369.1 - 8 5.4 0.1 19 4.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) CDC45 PF02724.9 CDI81370.1 - 0.0076 14.3 7.9 0.0099 13.9 5.5 1.1 1 0 0 1 1 1 1 CDC45-like protein Vfa1 PF08432.5 CDI81370.1 - 0.008 16.2 18.1 0.013 15.4 12.5 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF1510 PF07423.6 CDI81370.1 - 0.019 14.3 13.3 0.026 13.9 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FLO_LFY PF01698.11 CDI81370.1 - 0.026 13.3 2.8 0.038 12.8 1.9 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein MIP-T3 PF10243.4 CDI81370.1 - 0.08 11.3 14.4 0.11 10.9 10.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 TRAP_alpha PF03896.11 CDI81370.1 - 0.11 11.5 8.2 0.16 10.9 5.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit U79_P34 PF03064.11 CDI81370.1 - 0.12 11.8 12.9 0.19 11.1 9.0 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 FAM176 PF14851.1 CDI81370.1 - 0.13 11.8 5.2 0.23 11.1 3.6 1.3 1 0 0 1 1 1 0 FAM176 family DUF2722 PF10846.3 CDI81370.1 - 0.14 11.1 10.9 0.21 10.6 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) YqfQ PF14181.1 CDI81370.1 - 0.16 11.9 10.7 0.32 11.0 7.4 1.4 1 0 0 1 1 1 0 YqfQ-like protein DUF3449 PF11931.3 CDI81370.1 - 0.31 10.5 8.3 0.58 9.6 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Sec62 PF03839.11 CDI81370.1 - 5.5 6.3 17.6 8.9 5.6 12.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 WD40 PF00400.27 CDI81379.1 - 0.0014 18.4 0.0 0.0067 16.2 0.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF3628 PF12300.3 CDI81379.1 - 0.0075 16.3 3.1 0.0075 16.3 2.1 4.0 3 1 0 3 3 3 2 Protein of unknown function (DUF3628) CBM_20 PF00686.14 CDI81380.1 - 1.3e-10 40.7 0.0 1.3e-10 40.7 0.0 2.3 2 0 0 2 2 2 1 Starch binding domain SR-25 PF10500.4 CDI81380.1 - 0.33 10.3 20.7 0.46 9.9 14.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAT1 PF09770.4 CDI81380.1 - 1.7 6.8 56.0 2.2 6.3 38.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_C13 PF01650.13 CDI81384.1 - 2.1e-27 96.0 0.6 1.1e-17 64.2 0.1 3.1 2 1 0 3 3 3 2 Peptidase C13 family Plasmodium_Vir PF05795.6 CDI81384.1 - 0.0011 18.2 2.4 0.0072 15.5 0.1 2.4 2 0 0 2 2 2 1 Plasmodium vivax Vir protein DUF1510 PF07423.6 CDI81384.1 - 0.0017 17.8 12.1 0.0017 17.8 8.4 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF1510) Med15 PF09606.5 CDI81384.1 - 0.0035 15.6 23.2 0.0035 15.6 16.1 4.4 3 2 0 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal Zip PF02535.17 CDI81384.1 - 0.024 13.6 10.7 0.031 13.3 5.6 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Ribosomal_60s PF00428.14 CDI81384.1 - 0.8 10.1 11.6 4.1 7.8 0.5 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein NAD_binding_5 PF07994.7 CDI81384.1 - 1.2 8.5 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase VID27 PF08553.5 CDI81385.1 - 8.2e-08 30.9 0.3 9e-08 30.8 0.2 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein eIF-5_eIF-2B PF01873.12 CDI81388.1 - 1.2e-37 128.3 0.0 6.8e-37 125.9 0.0 1.8 1 1 1 2 2 2 1 Domain found in IF2B/IF5 Elf1 PF05129.8 CDI81388.1 - 1.1 8.9 4.2 0.84 9.3 0.1 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like CPW_WPC PF09717.5 CDI81390.1 - 0.018 15.6 0.3 0.018 15.6 0.2 1.7 2 0 0 2 2 2 0 Plasmodium falciparum domain of unknown function (CPW_WPC) TPPII_N PF12583.3 CDI81390.1 - 0.43 10.7 12.2 0.56 10.3 8.4 1.1 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal RskA PF10099.4 CDI81390.1 - 1.8 8.2 14.9 2.9 7.5 10.3 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Na_Ca_ex PF01699.19 CDI81391.1 - 2.3e-17 62.8 10.9 2.3e-17 62.8 7.5 1.6 2 0 0 2 2 2 1 Sodium/calcium exchanger protein DUF872 PF05915.7 CDI81391.1 - 7 6.5 7.1 0.88 9.4 0.6 2.3 1 1 2 3 3 3 0 Eukaryotic protein of unknown function (DUF872) MIP-T3 PF10243.4 CDI81393.1 - 0.00013 20.6 60.2 0.029 12.8 13.1 3.2 3 0 0 3 3 3 3 Microtubule-binding protein MIP-T3 DUF2457 PF10446.4 CDI81393.1 - 0.00016 20.5 6.1 0.00016 20.5 4.2 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2457) Nop14 PF04147.7 CDI81393.1 - 0.00022 19.3 8.5 0.00022 19.3 5.9 3.1 3 0 0 3 3 3 2 Nop14-like family CDC45 PF02724.9 CDI81393.1 - 0.001 17.2 8.3 0.001 17.2 5.7 3.1 3 0 0 3 3 3 2 CDC45-like protein BUD22 PF09073.5 CDI81393.1 - 0.0017 17.5 8.8 0.0017 17.5 6.1 3.2 3 0 0 3 3 3 1 BUD22 YL1 PF05764.8 CDI81393.1 - 0.0062 16.1 10.3 0.0062 16.1 7.1 3.1 3 0 0 3 3 2 2 YL1 nuclear protein Sec62 PF03839.11 CDI81393.1 - 0.059 12.7 0.2 0.059 12.7 0.1 3.3 3 0 0 3 3 2 0 Translocation protein Sec62 SDA1 PF05285.7 CDI81393.1 - 0.069 12.4 72.4 0.049 12.8 4.7 3.1 3 0 0 3 3 3 0 SDA1 Cortexin PF11057.3 CDI81393.1 - 0.62 9.6 4.3 0.53 9.9 1.2 2.3 2 0 0 2 2 2 0 Cortexin of kidney Daxx PF03344.10 CDI81393.1 - 1.1 7.7 79.6 0.19 10.2 7.8 3.2 3 0 0 3 3 3 0 Daxx Family SAGA-Tad1 PF12767.2 CDI81393.1 - 6.8 6.2 26.6 0.091 12.4 10.7 2.9 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF1510 PF07423.6 CDI81393.1 - 7.2 5.9 77.1 0.13 11.6 7.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) Rrp15p PF07890.7 CDI81395.1 - 2.8e-06 27.4 6.7 2.8e-06 27.4 4.7 4.7 1 1 3 4 4 4 1 Rrp15p PAT1 PF09770.4 CDI81395.1 - 2 6.5 118.0 2.5 6.2 81.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Helicase_C PF00271.26 CDI81396.1 - 2.1e-30 104.3 0.2 1e-29 102.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDI81396.1 - 3.3e-16 59.2 0.9 2.5e-12 46.6 0.0 3.1 2 1 1 3 3 3 2 DEAD/DEAH box helicase DUF1253 PF06862.7 CDI81396.1 - 0.02 13.2 0.0 0.03 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) DSS1_SEM1 PF05160.8 CDI81397.1 - 0.0093 15.7 5.3 0.0093 15.7 3.6 2.2 1 1 1 2 2 2 1 DSS1/SEM1 family Phage_GP20 PF06810.6 CDI81397.1 - 0.048 13.0 0.5 0.047 13.1 0.4 1.0 1 0 0 1 1 1 0 Phage minor structural protein GP20 SPX PF03105.14 CDI81397.1 - 0.11 12.2 1.1 0.12 12.1 0.8 1.1 1 0 0 1 1 1 0 SPX domain Cwf_Cwc_15 PF04889.7 CDI81397.1 - 0.21 11.2 5.2 0.22 11.1 3.6 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DEAD PF00270.24 CDI81398.1 - 3.4e-33 114.4 0.1 8.9e-33 113.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI81398.1 - 4.3e-18 64.9 0.0 1.4e-17 63.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DSPc PF00782.15 CDI81398.1 - 9.5e-08 31.7 0.1 2.1e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDI81398.1 - 0.14 11.4 0.3 0.26 10.5 0.2 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase CBM_20 PF00686.14 CDI81398.1 - 0.18 11.4 0.5 1.2 8.8 0.0 2.6 3 0 0 3 3 3 0 Starch binding domain Ribosomal_L22e PF01776.12 CDI81399.1 - 3.1e-45 152.7 1.7 3.8e-45 152.4 1.2 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF288 PF03385.12 CDI81399.1 - 0.05 12.0 0.1 0.054 11.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF288 DUF3228 PF11539.3 CDI81400.1 - 6.9e-33 113.4 0.0 6.4e-29 100.4 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3228) eIF3_p135 PF12807.2 CDI81402.1 - 5.1e-12 46.0 0.1 1.4e-11 44.6 0.0 1.8 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 PWI PF01480.12 CDI81403.1 - 5.4e-28 96.9 0.0 8.8e-28 96.2 0.0 1.3 1 0 0 1 1 1 1 PWI domain PYC_OADA PF02436.13 CDI81403.1 - 0.001 18.5 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain PhoD PF09423.5 CDI81405.1 - 3.4e-13 48.9 1.4 6.1e-13 48.1 0.9 1.3 1 0 0 1 1 1 1 PhoD-like phosphatase TerD PF02342.13 CDI81406.1 - 3.8e-13 49.1 0.0 2e-12 46.8 0.0 2.1 1 1 0 1 1 1 1 TerD domain DUF3584 PF12128.3 CDI81406.1 - 0.041 11.2 2.7 0.059 10.7 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 CDI81406.1 - 0.069 12.3 0.9 0.33 10.0 0.7 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TMP_2 PF06791.8 CDI81406.1 - 0.085 12.4 0.1 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Prophage tail length tape measure protein Apolipoprotein PF01442.13 CDI81406.1 - 0.4 10.1 4.4 1.3 8.4 3.1 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain IncA PF04156.9 CDI81406.1 - 7.4 6.1 11.0 3.7 7.1 2.3 2.4 1 1 1 2 2 2 0 IncA protein DUF3073 PF11273.3 CDI81412.1 - 0.23 12.0 1.3 3.6 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) zf-met PF12874.2 CDI81415.1 - 0.00014 21.8 1.4 0.00028 20.9 1.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CDI81415.1 - 0.0025 17.9 1.4 0.0052 16.8 1.0 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF1168 PF06658.7 CDI81415.1 - 9.9 5.6 12.1 2.9 7.3 5.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Shadoo PF14999.1 CDI81417.1 - 0.38 10.6 4.9 0.93 9.3 3.4 1.6 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective RNA_pol_Rpb1_5 PF04998.12 CDI81418.1 - 6.8e-18 64.9 1.9 2.2e-17 63.2 1.9 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Gly-zipper_OmpA PF13436.1 CDI81418.1 - 4.5 6.9 24.7 1.5 8.4 14.1 2.1 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain RNA_pol_Rpb1_5 PF04998.12 CDI81419.1 - 1.4e-35 122.9 0.1 2.6e-35 122.0 0.1 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.12 CDI81419.1 - 3.9e-20 71.6 0.3 3.9e-20 71.6 0.2 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 zf-CCHC PF00098.18 CDI81420.1 - 3.2e-08 33.0 12.1 0.00084 19.1 1.7 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 CDI81420.1 - 0.0048 16.5 7.2 0.16 11.6 0.5 2.7 3 0 0 3 3 3 2 Zinc knuckle DnaJ_CXXCXGXG PF00684.14 CDI81420.1 - 0.31 11.1 9.5 0.73 9.9 6.6 1.6 1 1 0 1 1 1 0 DnaJ central domain zf-C4pol PF14260.1 CDI81420.1 - 0.79 9.7 3.6 10 6.2 0.2 2.6 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zf-CCHC_2 PF13696.1 CDI81420.1 - 0.9 9.0 3.1 0.44 10.0 0.2 1.9 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 CDI81420.1 - 3.3 7.5 10.7 0.41 10.4 1.3 2.5 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.1 CDI81421.1 - 2.1e-07 31.3 0.0 4.3e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 CDI81421.1 - 4.8e-06 26.3 0.1 1e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 CDI81421.1 - 8.7e-06 25.5 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 CDI81421.1 - 2.8e-05 24.0 0.0 5.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease PH PF00169.24 CDI81422.1 - 8.5e-05 22.7 0.0 0.00014 21.9 0.0 1.4 1 1 0 1 1 1 1 PH domain Mcp5_PH PF12814.2 CDI81422.1 - 0.0076 16.1 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Pollen_allerg_2 PF01620.11 CDI81422.1 - 0.011 16.0 4.4 0.021 15.1 3.0 1.5 1 0 0 1 1 1 0 Ribonuclease (pollen allergen) PH_10 PF15411.1 CDI81422.1 - 0.014 15.5 0.0 0.046 13.9 0.0 1.7 1 1 1 2 2 2 0 Pleckstrin homology domain Med3 PF11593.3 CDI81422.1 - 0.38 9.9 8.1 0.4 9.8 5.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PHD PF00628.24 CDI81423.1 - 1e-06 28.2 17.3 6.4e-06 25.7 4.7 6.8 7 0 0 7 7 7 2 PHD-finger DUF755 PF05501.6 CDI81423.1 - 0.0014 18.6 17.3 0.0014 18.6 12.0 16.2 14 1 2 16 16 16 2 Domain of unknown function (DUF755) Yos1 PF08571.5 CDI81423.1 - 5.9 7.0 2.1 31 4.7 0.0 3.3 2 0 0 2 2 2 0 Yos1-like RCR PF12273.3 CDI81424.1 - 1.1 9.8 7.0 4.3 7.9 1.7 2.2 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red AAA PF00004.24 CDI81425.1 - 2.5e-53 179.8 0.0 4.4e-25 88.4 0.0 4.8 3 1 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI81425.1 - 4.5e-10 39.4 3.1 4.8e-05 23.1 0.1 4.3 4 1 0 4 4 3 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CDI81425.1 - 2.1e-08 33.4 0.0 0.00026 20.1 0.0 3.2 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 CDI81425.1 - 3.1e-08 33.2 7.2 0.0015 17.9 0.0 4.2 5 0 0 5 5 4 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 CDI81425.1 - 3.1e-08 33.0 0.1 0.0027 16.9 0.1 3.0 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 CDI81425.1 - 8.3e-08 33.0 0.0 0.0066 17.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.17 CDI81425.1 - 6.7e-07 29.4 0.0 0.035 14.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.1 CDI81425.1 - 1.5e-06 28.1 0.1 0.0019 18.0 0.0 6.8 7 3 0 7 7 6 2 AAA domain AAA_14 PF13173.1 CDI81425.1 - 4.3e-06 26.6 0.0 0.0058 16.5 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CDI81425.1 - 6e-06 26.4 12.3 0.0054 16.8 0.0 5.5 4 3 0 4 4 4 2 AAA domain AAA_18 PF13238.1 CDI81425.1 - 6.3e-06 26.5 3.4 0.13 12.5 0.0 4.3 5 0 0 5 5 3 2 AAA domain AAA_25 PF13481.1 CDI81425.1 - 2.8e-05 23.6 0.1 0.42 9.9 0.0 4.0 3 1 0 3 3 3 2 AAA domain TIP49 PF06068.8 CDI81425.1 - 3.9e-05 22.5 0.0 0.1 11.2 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus AAA_16 PF13191.1 CDI81425.1 - 4.5e-05 23.5 6.4 0.002 18.1 0.1 6.2 4 4 1 5 5 3 2 AAA ATPase domain NACHT PF05729.7 CDI81425.1 - 0.00018 21.2 5.7 0.13 11.8 0.0 4.8 4 1 0 4 4 4 2 NACHT domain AAA_3 PF07726.6 CDI81425.1 - 0.0016 18.0 0.0 0.16 11.5 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SR-25 PF10500.4 CDI81425.1 - 0.0072 15.8 17.0 0.0072 15.8 11.7 9.1 7 2 2 9 9 5 1 Nuclear RNA-splicing-associated protein NTPase_1 PF03266.10 CDI81425.1 - 0.022 14.4 0.0 5.1 6.7 0.0 2.7 2 0 0 2 2 2 0 NTPase Arch_ATPase PF01637.13 CDI81425.1 - 0.047 13.3 0.0 5.8 6.5 0.0 3.1 2 0 0 2 2 2 0 Archaeal ATPase AAA_24 PF13479.1 CDI81425.1 - 0.21 11.1 0.0 0.64 9.5 0.0 5.3 6 0 0 6 6 5 0 AAA domain SKI PF01202.17 CDI81425.1 - 1.1 9.1 0.0 1.1 9.1 0.0 5.4 7 0 0 7 7 7 0 Shikimate kinase WD40 PF00400.27 CDI81426.1 - 1.5e-54 179.9 24.6 1.4e-10 40.6 0.2 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 CDI81426.1 - 4e-07 29.4 0.0 2.1 7.8 0.0 5.1 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.1 CDI81426.1 - 0.00015 20.9 0.7 0.00063 18.9 0.1 2.2 3 0 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.6 CDI81426.1 - 0.0017 17.1 2.1 0.69 8.5 0.0 3.6 2 1 2 4 4 4 1 Nup133 N terminal like Coatomer_WDAD PF04053.9 CDI81426.1 - 0.0081 14.9 0.2 2.1 7.0 0.1 2.7 3 0 0 3 3 3 2 Coatomer WD associated region Lactonase PF10282.4 CDI81426.1 - 0.0091 15.1 2.2 1.6 7.7 0.1 3.1 3 0 0 3 3 3 1 Lactonase, 7-bladed beta-propeller TFIIIC_delta PF12657.2 CDI81426.1 - 0.012 15.3 9.1 10 5.7 6.7 3.7 2 1 1 3 3 3 0 Transcription factor IIIC subunit delta N-term RAB3GAP2_N PF14655.1 CDI81426.1 - 0.039 12.9 9.6 0.57 9.1 0.2 2.4 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus CBP4 PF07960.6 CDI81426.1 - 0.11 12.0 13.1 0.023 14.3 2.8 2.3 2 0 0 2 2 2 0 CBP4 MMR1 PF08505.5 CDI81426.1 - 0.12 12.4 6.6 0.28 11.2 4.6 1.5 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein dsDNA_bind PF01984.15 CDI81426.1 - 6.1 6.8 21.7 2.2 8.2 5.9 2.4 2 0 0 2 2 2 0 Double-stranded DNA-binding domain HSP70 PF00012.15 CDI81427.1 - 3.9e-16 58.1 51.8 2e-09 35.9 0.7 5.3 3 2 0 3 3 3 2 Hsp70 protein EF-hand_8 PF13833.1 CDI81428.1 - 0.00016 21.2 0.1 0.00032 20.2 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI81428.1 - 0.00021 20.3 0.6 0.001 18.1 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 CDI81428.1 - 0.0017 18.0 0.2 0.0058 16.4 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain PAT1 PF09770.4 CDI81428.1 - 0.011 13.9 108.9 0.015 13.6 75.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EF-hand_7 PF13499.1 CDI81428.1 - 0.012 15.7 0.8 0.038 14.1 0.0 2.2 3 0 0 3 3 3 0 EF-hand domain pair TFIIA PF03153.8 CDI81428.1 - 0.64 9.8 83.0 1 9.1 57.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit His_Phos_1 PF00300.17 CDI81429.1 - 4.7e-10 39.7 0.7 7.2e-05 22.9 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) CDK5_activator PF03261.10 CDI81429.1 - 0.0059 15.9 5.4 0.0074 15.6 3.8 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein PAT1 PF09770.4 CDI81429.1 - 0.013 13.8 4.5 0.012 13.8 3.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 APC_CDC26 PF10471.4 CDI81429.1 - 0.073 13.8 8.8 0.13 12.9 6.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 PadR PF03551.9 CDI81429.1 - 0.11 12.2 0.5 0.2 11.4 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family Spt20 PF12090.3 CDI81429.1 - 0.26 10.5 2.2 0.3 10.4 1.5 1.1 1 0 0 1 1 1 0 Spt20 family Herpes_capsid PF06112.6 CDI81429.1 - 0.32 11.0 12.1 0.49 10.4 8.4 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CDK2AP PF09806.4 CDI81429.1 - 1.2 9.3 19.6 1 9.5 12.8 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Sporozoite_P67 PF05642.6 CDI81429.1 - 1.4 6.6 7.6 1.7 6.4 5.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4407 PF14362.1 CDI81430.1 - 0.0058 15.6 9.3 0.0058 15.6 6.5 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF4407) RAP1 PF07218.6 CDI81430.1 - 0.064 11.3 7.7 0.093 10.8 5.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AAA_23 PF13476.1 CDI81430.1 - 0.31 11.3 26.0 1.1 9.5 7.0 2.2 2 0 0 2 2 2 0 AAA domain Yos1 PF08571.5 CDI81430.1 - 0.31 11.1 0.0 0.31 11.1 0.0 2.8 4 1 0 4 4 4 0 Yos1-like CAF-1_p150 PF11600.3 CDI81430.1 - 0.69 9.2 43.1 0.021 14.1 12.6 2.6 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Clat_adaptor_s PF01217.15 CDI81431.1 - 1.3e-43 148.1 3.2 1.4e-43 148.0 2.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Gln-synt_N PF03951.14 CDI81432.1 - 3.7e-21 74.4 0.0 8.7e-21 73.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_C PF00120.19 CDI81432.1 - 1.1e-08 34.5 0.0 2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain DUF1053 PF06327.9 CDI81432.1 - 0.013 15.7 1.0 0.023 15.0 0.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) DUF1247 PF06851.6 CDI81432.1 - 0.07 12.7 0.8 0.11 12.1 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) SNN_cytoplasm PF09051.5 CDI81432.1 - 0.1 12.3 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Stannin cytoplasmic MRP-S26 PF14943.1 CDI81432.1 - 0.17 11.4 4.1 0.58 9.6 3.2 1.6 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 PP2C PF00481.16 CDI81434.1 - 1.3e-36 126.3 0.0 2e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CDI81434.1 - 0.0049 16.6 0.0 0.16 11.6 0.0 2.4 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Biotin_lipoyl PF00364.17 CDI81435.1 - 4.9e-33 112.5 0.1 1.9e-15 56.2 0.0 2.3 2 0 0 2 2 2 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 CDI81435.1 - 1.5e-11 43.7 16.0 0.00074 19.1 0.0 4.4 3 2 1 4 4 4 3 Biotin-lipoyl like HlyD_2 PF12700.2 CDI81435.1 - 8.5e-09 35.0 0.5 0.0033 16.6 0.0 3.4 2 2 1 3 3 3 3 HlyD family secretion protein HlyD_3 PF13437.1 CDI81435.1 - 1.1e-06 28.8 0.5 0.28 11.5 0.1 4.2 3 1 1 4 4 4 2 HlyD family secretion protein GCV_H PF01597.14 CDI81435.1 - 0.00064 19.4 0.7 0.27 10.9 0.0 3.0 1 1 2 3 3 3 2 Glycine cleavage H-protein Peptidase_M23 PF01551.17 CDI81435.1 - 0.022 14.8 1.5 2.5 8.2 0.1 3.5 2 2 1 3 3 3 0 Peptidase family M23 DUF2118 PF09891.4 CDI81435.1 - 0.036 13.7 0.1 15 5.2 0.0 2.9 2 2 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2118) Nop25 PF09805.4 CDI81437.1 - 0.013 15.5 4.2 0.013 15.5 2.9 1.4 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Macoilin PF09726.4 CDI81437.1 - 0.014 13.7 30.9 0.02 13.1 21.4 1.2 1 0 0 1 1 1 0 Transmembrane protein BTV_NS2 PF04514.7 CDI81437.1 - 0.36 9.6 3.6 0.48 9.2 2.5 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF572 PF04502.8 CDI81437.1 - 0.75 8.9 22.4 1 8.5 15.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) BAF1_ABF1 PF04684.8 CDI81438.1 - 0.002 17.0 15.6 0.002 17.0 10.8 8.5 2 1 5 8 8 8 1 BAF1 / ABF1 chromatin reorganising factor Pkinase PF00069.20 CDI81439.1 - 3.8e-08 32.7 1.0 2.8e-07 29.9 0.5 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI81439.1 - 8.8e-06 24.9 0.2 0.00015 20.9 0.0 2.3 1 1 2 3 3 3 1 Protein tyrosine kinase DUF2457 PF10446.4 CDI81439.1 - 0.0038 16.0 1.6 0.0066 15.2 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) APC_CDC26 PF10471.4 CDI81439.1 - 0.044 14.5 14.1 1.2 9.9 5.6 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Ipi1_N PF12333.3 CDI81439.1 - 0.39 10.7 4.9 0.18 11.8 0.3 2.1 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation DUF788 PF05620.6 CDI81439.1 - 0.71 9.7 8.5 0.5 10.2 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF788) Ribosomal_60s PF00428.14 CDI81439.1 - 1.1 9.7 27.3 0.11 12.8 1.7 2.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein AAA_23 PF13476.1 CDI81439.1 - 1.2 9.3 8.3 1.6 8.9 5.7 1.2 1 0 0 1 1 1 0 AAA domain SR-25 PF10500.4 CDI81439.1 - 2.6 7.4 12.6 2.5 7.4 4.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SOBP PF15279.1 CDI81439.1 - 6.2 7.1 12.9 7.6 6.8 8.4 1.3 1 1 0 1 1 1 0 Sine oculis-binding protein DUF3446 PF11928.3 CDI81439.1 - 7.7 6.7 9.6 2.3 8.4 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF3446) DUF3273 PF11677.3 CDI81440.1 - 9.8e-06 25.0 0.0 2.4e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3273) Peptidase_M17_N PF02789.12 CDI81440.1 - 0.19 11.4 1.7 0.29 10.8 1.2 1.2 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain Med15 PF09606.5 CDI81441.1 - 1.3 7.1 119.8 1.8 6.6 83.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal UFD1 PF03152.9 CDI81442.1 - 5.3e-39 133.1 0.0 6e-39 132.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 TMEM154 PF15102.1 CDI81445.1 - 0.13 11.9 1.2 0.3 10.7 0.9 1.5 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.1 CDI81445.1 - 2.9 8.3 5.2 1.9 8.9 0.0 3.0 3 1 1 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain BatA PF07584.6 CDI81445.1 - 5.9 7.1 8.1 2 8.6 2.8 2.3 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Syntaxin PF00804.20 CDI81446.1 - 2.2e-06 27.7 1.6 8.6e-06 25.8 1.1 1.8 1 1 0 1 1 1 1 Syntaxin PEP-utilisers_N PF05524.8 CDI81446.1 - 0.0079 15.9 1.0 1.8 8.3 0.2 2.1 2 0 0 2 2 2 2 PEP-utilising enzyme, N-terminal COG5 PF10392.4 CDI81446.1 - 0.056 13.4 0.9 0.13 12.2 0.1 1.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DASH_Dam1 PF08653.5 CDI81446.1 - 0.094 12.4 0.3 0.22 11.3 0.1 1.7 2 0 0 2 2 2 0 DASH complex subunit Dam1 KxDL PF10241.4 CDI81446.1 - 0.22 11.4 2.8 11 6.0 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein E1_dh PF00676.15 CDI81447.1 - 1.7e-70 237.1 0.2 1.6e-69 233.9 0.1 1.9 1 1 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.16 CDI81447.1 - 0.012 14.3 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain PBC PF03792.8 CDI81448.1 - 0.042 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 PBC domain Ribosomal_60s PF00428.14 CDI81449.1 - 0.00052 20.3 24.6 0.035 14.5 5.5 2.3 2 0 0 2 2 2 2 60s Acidic ribosomal protein SR-25 PF10500.4 CDI81449.1 - 0.026 14.0 12.3 0.038 13.4 8.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1645 PF07816.6 CDI81449.1 - 0.032 14.7 9.2 0.048 14.1 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) DUF2371 PF10177.4 CDI81455.1 - 0.008 16.0 0.0 2 8.3 0.0 2.2 1 1 1 2 2 2 2 Uncharacterised conserved protein (DUF2371) MatE PF01554.13 CDI81455.1 - 0.0087 15.6 8.5 0.18 11.3 0.1 2.3 2 0 0 2 2 2 2 MatE TFIIA PF03153.8 CDI81455.1 - 0.0089 15.9 3.1 0.012 15.4 2.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TMEM51 PF15345.1 CDI81455.1 - 0.072 12.7 0.4 6.8 6.3 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 Pex14_N PF04695.8 CDI81455.1 - 0.48 10.4 12.0 0.12 12.4 0.3 2.2 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region R_equi_Vir PF05526.6 CDI81455.1 - 2.1 7.9 4.3 3.9 7.0 1.6 2.0 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein Gastrin PF00918.12 CDI81455.1 - 4.4 8.1 7.1 12 6.7 0.7 2.3 2 0 0 2 2 2 0 Gastrin/cholecystokinin family DUF3306 PF11748.3 CDI81455.1 - 6.2 7.5 9.5 19 5.9 3.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DUF3530 PF12048.3 CDI81455.1 - 9.3 5.1 15.3 4.8 6.0 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) PIG-U PF06728.8 CDI81456.1 - 0.2 10.4 0.7 1.8 7.3 0.0 2.5 2 0 0 2 2 2 0 GPI transamidase subunit PIG-U MIP-T3 PF10243.4 CDI81461.1 - 0.0019 16.7 67.0 0.0019 16.7 46.4 2.2 2 1 0 2 2 2 1 Microtubule-binding protein MIP-T3 DctQ PF04290.7 CDI81461.1 - 0.064 13.0 0.7 0.12 12.0 0.5 1.4 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component Methyltransf_26 PF13659.1 CDI81462.1 - 1.2e-11 44.6 0.0 2.3e-11 43.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 CDI81462.1 - 1.1e-09 38.1 0.1 1.1e-08 34.8 0.1 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.13 CDI81462.1 - 3.8e-07 29.8 3.7 0.00028 20.4 0.1 3.7 3 1 1 4 4 4 2 DNA methylase MT-A70 PF05063.9 CDI81462.1 - 0.073 12.6 0.0 0.61 9.6 0.0 2.3 3 0 0 3 3 3 0 MT-A70 PAT1 PF09770.4 CDI81463.1 - 4.9 5.2 9.4 6.7 4.8 6.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sporozoite_P67 PF05642.6 CDI81463.1 - 9.7 3.9 12.6 1.3 6.8 5.2 1.7 1 1 1 2 2 2 0 Sporozoite P67 surface antigen CwfJ_C_2 PF04676.9 CDI81469.1 - 0.16 12.5 4.5 0.15 12.5 0.3 2.4 2 0 0 2 2 2 0 Protein similar to CwfJ C-terminus 2 DUF1754 PF08555.5 CDI81469.1 - 0.31 11.6 15.0 0.19 12.3 4.2 2.3 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Macoilin PF09726.4 CDI81469.1 - 0.83 7.8 18.7 1.2 7.3 13.0 1.1 1 0 0 1 1 1 0 Transmembrane protein Vfa1 PF08432.5 CDI81469.1 - 1.7 8.6 13.3 3.8 7.4 2.9 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 TFIIA PF03153.8 CDI81469.1 - 1.9 8.2 17.6 2.5 7.8 12.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit APC_CDC26 PF10471.4 CDI81469.1 - 2 9.2 19.7 0.052 14.2 2.6 3.6 3 1 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 ASFV_J13L PF05568.6 CDI81469.1 - 2.5 7.6 8.2 1.3 8.5 4.0 1.8 2 1 1 3 3 3 0 African swine fever virus J13L protein YfzA PF14118.1 CDI81471.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 YfzA-like protein CAP PF00188.21 CDI81473.1 - 7.8e-08 32.8 0.1 1.8e-07 31.6 0.1 1.7 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TSP_1 PF00090.14 CDI81473.1 - 0.0002 21.3 7.4 0.0002 21.3 5.1 2.2 2 0 0 2 2 2 1 Thrombospondin type 1 domain AP4E_app_platf PF14807.1 CDI81475.1 - 7.3e-07 29.3 0.0 2e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Pex26 PF07163.7 CDI81476.1 - 0.025 13.4 0.9 0.029 13.3 0.7 1.2 1 0 0 1 1 1 0 Pex26 protein Lipoprotein_6 PF01441.14 CDI81476.1 - 0.04 13.7 0.2 0.052 13.3 0.1 1.3 1 0 0 1 1 1 0 Lipoprotein MIP PF00230.15 CDI81478.1 - 1.9e-13 50.4 34.2 6.3e-09 35.6 11.4 3.8 1 1 3 4 4 4 4 Major intrinsic protein DUF1049 PF06305.6 CDI81478.1 - 0.98 8.9 7.9 0.14 11.6 1.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1049) PTPA PF03095.10 CDI81480.1 - 3.9e-64 216.6 0.0 6.2e-64 216.0 0.0 1.3 1 1 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Hormone_3 PF00159.13 CDI81481.1 - 0.73 9.8 4.3 1.2 9.1 0.1 3.0 2 1 0 2 2 2 0 Pancreatic hormone peptide Hex_IIIa PF02455.11 CDI81481.1 - 0.98 8.0 7.7 1.2 7.7 5.3 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF2043 PF09740.4 CDI81481.1 - 1.3 9.1 4.5 1.8 8.6 2.3 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2043) SLX9 PF15341.1 CDI81481.1 - 1.3 9.4 13.6 0.55 10.6 0.6 2.1 1 1 0 2 2 2 0 Ribosome biogenesis protein SLX9 SAPS PF04499.10 CDI81481.1 - 2.8 6.4 6.4 3.5 6.1 4.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF765 PF05570.6 CDI81481.1 - 3.1 7.8 6.3 5.3 7.0 0.3 3.0 3 0 0 3 3 3 0 Circovirus protein of unknown function (DUF765) TPR_1 PF00515.23 CDI81482.1 - 1.2e-09 37.3 0.6 3.7e-05 23.1 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI81482.1 - 8.9e-09 34.6 1.1 0.0014 18.3 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 CDI81482.1 - 1e-08 34.6 0.6 2.5e-08 33.4 0.4 1.7 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 CDI81482.1 - 4.7e-05 23.9 1.1 4.7e-05 23.9 0.7 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDI81482.1 - 0.0057 16.5 2.3 0.041 13.8 1.5 2.3 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI81482.1 - 0.009 16.1 0.0 0.009 16.1 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF4638 PF15472.1 CDI81482.1 - 0.038 13.5 4.2 0.049 13.2 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Baculo_p24 PF05073.7 CDI81482.1 - 0.076 12.5 2.4 0.1 12.1 1.6 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein TPR_14 PF13428.1 CDI81482.1 - 0.22 12.2 0.0 0.22 12.2 0.0 3.4 3 1 1 4 4 3 0 Tetratricopeptide repeat Activator_LAG-3 PF11498.3 CDI81482.1 - 0.24 10.1 26.4 0.33 9.6 18.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ARGLU PF15346.1 CDI81482.1 - 0.26 11.0 17.1 0.68 9.7 5.7 2.1 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Allexi_40kDa PF05549.6 CDI81482.1 - 0.75 9.0 5.8 0.34 10.1 1.9 1.7 1 1 0 2 2 2 0 Allexivirus 40kDa protein DUF2992 PF11208.3 CDI81482.1 - 0.94 9.3 19.3 0.094 12.6 7.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) FadA PF09403.5 CDI81482.1 - 1.8 8.6 0.0 1.8 8.6 0.0 3.0 2 1 1 3 3 3 0 Adhesion protein FadA AAA_23 PF13476.1 CDI81482.1 - 2.2 8.5 12.8 0.33 11.2 5.4 1.8 2 0 0 2 2 2 0 AAA domain Syntaxin PF00804.20 CDI81482.1 - 2.7 8.1 16.6 3.3 7.9 6.8 2.2 2 0 0 2 2 2 0 Syntaxin FlxA PF14282.1 CDI81482.1 - 3.3 7.6 29.8 0.94 9.4 0.6 2.4 2 0 0 2 2 2 0 FlxA-like protein DUF1840 PF08895.6 CDI81482.1 - 6.4 6.8 10.5 10 6.1 4.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DFP PF04127.10 CDI81483.1 - 2.7e-14 53.2 0.0 1.6e-07 31.1 0.0 3.3 3 0 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein EF-hand_6 PF13405.1 CDI81484.1 - 0.0025 17.5 0.9 0.0099 15.6 0.6 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 CDI81484.1 - 0.053 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 CDI81484.1 - 0.083 12.2 2.7 0.28 10.6 1.9 1.9 1 0 0 1 1 1 0 EF hand CDC50 PF03381.10 CDI81485.1 - 1.1e-50 172.3 0.0 1.5e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family MFS_2 PF13347.1 CDI81487.1 - 0.26 9.6 13.0 0.7 8.2 9.0 1.6 1 1 0 1 1 1 0 MFS/sugar transport protein Prenyltrans PF00432.16 CDI81488.1 - 5.9e-39 131.2 20.2 2e-08 33.6 0.2 6.4 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CDI81488.1 - 3.3e-26 91.9 2.8 5.9e-14 52.4 0.0 4.0 3 1 2 5 5 5 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 CDI81488.1 - 8.9e-08 32.1 0.0 0.01 15.8 0.0 3.7 1 1 2 4 4 4 3 Prenyltransferase-like A2M_comp PF07678.9 CDI81488.1 - 0.0063 15.7 0.0 17 4.5 0.0 3.2 3 0 0 3 3 3 2 A-macroglobulin complement component ISG65-75 PF11727.3 CDI81489.1 - 0.12 11.4 4.6 0.16 10.9 3.2 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein RRM_5 PF13893.1 CDI81490.1 - 4.3e-10 39.2 0.0 6.1e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI81490.1 - 4.1e-07 29.5 0.0 7.5e-07 28.6 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI81490.1 - 0.00023 21.0 0.0 0.001 19.0 0.0 1.9 1 1 1 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) ABC_tran PF00005.22 CDI81492.1 - 9.2e-18 64.8 0.0 9.2e-18 64.8 0.0 2.3 2 1 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 CDI81492.1 - 0.00011 22.2 9.1 0.00033 20.7 1.0 3.1 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.14 CDI81492.1 - 0.00064 19.0 0.7 0.018 14.2 0.0 3.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CDI81492.1 - 0.00092 20.0 0.0 0.002 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDI81492.1 - 0.0018 17.7 0.8 0.0032 16.9 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_13 PF13166.1 CDI81492.1 - 0.0049 15.4 0.1 0.0049 15.4 0.0 2.2 2 0 0 2 2 1 1 AAA domain DUF966 PF06136.8 CDI81492.1 - 0.014 14.8 15.4 0.018 14.4 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) PAP1 PF08601.5 CDI81492.1 - 0.014 15.0 21.6 0.021 14.5 15.0 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 NB-ARC PF00931.17 CDI81492.1 - 0.022 13.6 0.1 1.7 7.4 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain TFIIA PF03153.8 CDI81492.1 - 0.026 14.4 20.2 0.04 13.8 14.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF258 PF03193.11 CDI81492.1 - 0.027 13.6 0.1 0.054 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 CDI81492.1 - 0.04 13.3 0.0 0.075 12.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Neur_chan_memb PF02932.11 CDI81492.1 - 0.095 12.5 4.0 0.15 11.9 2.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_23 PF13476.1 CDI81492.1 - 0.4 10.9 0.1 0.4 10.9 0.0 3.3 2 1 1 4 4 2 0 AAA domain Macoilin PF09726.4 CDI81492.1 - 0.52 8.5 22.5 0.73 8.0 15.6 1.2 1 0 0 1 1 1 0 Transmembrane protein AAA_33 PF13671.1 CDI81492.1 - 0.97 9.3 4.2 0.38 10.6 0.2 2.4 2 1 0 2 2 2 0 AAA domain DUF2217 PF10265.4 CDI81492.1 - 1.5 7.4 14.0 2.2 6.9 9.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Mcm10 PF09332.6 CDI81492.1 - 2.4 7.4 16.2 3.4 6.9 11.2 1.3 1 0 0 1 1 1 0 Mcm10 replication factor Utp14 PF04615.8 CDI81492.1 - 5.5 5.0 24.8 7.9 4.5 17.2 1.1 1 0 0 1 1 1 0 Utp14 protein RCR PF12273.3 CDI81492.1 - 6.1 7.4 12.3 14 6.2 8.5 1.6 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red RAP1 PF07218.6 CDI81492.1 - 6.8 4.6 13.8 9.4 4.1 9.5 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) BTB PF00651.26 CDI81495.1 - 3.2e-15 56.0 0.0 2.5e-14 53.2 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain PP2C PF00481.16 CDI81496.1 - 1.1e-41 142.9 0.0 2.1e-41 142.0 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CDI81496.1 - 0.0081 15.8 0.0 0.44 10.2 0.0 2.5 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) TFIIA PF03153.8 CDI81500.1 - 0.016 15.1 11.6 0.019 14.8 8.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_M20 PF01546.23 CDI81500.1 - 0.026 14.0 0.8 0.044 13.2 0.4 1.4 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 DUF2893 PF11459.3 CDI81500.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknwon function (DUF2893) Pex14_N PF04695.8 CDI81500.1 - 0.36 10.8 11.7 0.049 13.6 4.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3273 PF11677.3 CDI81501.1 - 5.1e-77 258.7 5.5 5.8e-77 258.5 3.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) SCO1-SenC PF02630.9 CDI81503.1 - 6.9e-17 61.5 0.4 1.4e-09 37.7 0.0 2.7 2 2 1 3 3 2 2 SCO1/SenC SAPS PF04499.10 CDI81503.1 - 0.00011 21.0 2.2 0.00012 20.8 1.5 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Spore_coat_CotO PF14153.1 CDI81503.1 - 0.00026 20.5 13.7 0.00026 20.5 9.5 1.9 2 0 0 2 2 2 1 Spore coat protein CotO Med15 PF09606.5 CDI81503.1 - 0.00073 17.8 43.0 0.0011 17.2 29.8 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal AhpC-TSA PF00578.16 CDI81503.1 - 0.0049 16.5 0.1 0.011 15.3 0.1 1.6 1 0 0 1 1 1 1 AhpC/TSA family PAT1 PF09770.4 CDI81503.1 - 0.023 12.9 40.1 0.03 12.5 27.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.2 CDI81503.1 - 0.1 10.2 19.1 0.13 9.9 13.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SOBP PF15279.1 CDI81503.1 - 0.1 12.9 26.1 0.18 12.1 18.1 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein PIH1 PF08190.7 CDI81503.1 - 0.13 11.6 18.9 0.21 10.9 13.1 1.4 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 SR-25 PF10500.4 CDI81503.1 - 1.2 8.6 49.5 0.015 14.7 28.3 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1510 PF07423.6 CDI81503.1 - 4.1 6.6 21.8 8 5.7 15.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) HHH_8 PF14716.1 CDI81506.1 - 0.0055 16.8 0.0 0.23 11.6 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.18 CDI81506.1 - 0.12 12.1 0.0 0.34 10.7 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif SAPS PF04499.10 CDI81507.1 - 0.075 11.6 0.0 71 1.8 0.0 2.7 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein GOLD_2 PF13897.1 CDI81507.1 - 5.7 7.1 5.4 2.6 8.2 0.3 2.8 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking CENP-C_C PF11699.3 CDI81509.1 - 0.0049 16.8 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like WD40 PF00400.27 CDI81510.1 - 7.7e-18 63.6 17.8 3.7e-07 29.7 0.1 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat MutL PF13941.1 CDI81510.1 - 0.15 10.3 0.6 0.23 9.7 0.4 1.2 1 0 0 1 1 1 0 MutL protein zf-DHHC PF01529.15 CDI81511.1 - 5.8 6.2 10.1 6.8 6.0 0.2 3.0 3 0 0 3 3 3 0 DHHC palmitoyltransferase RabGAP-TBC PF00566.13 CDI81512.1 - 0.00085 18.8 1.1 0.0013 18.2 0.0 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Neur_chan_memb PF02932.11 CDI81512.1 - 0.75 9.6 4.0 1 9.1 0.0 2.6 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Activator_LAG-3 PF11498.3 CDI81512.1 - 1.1 7.8 20.9 3.1 6.4 14.5 1.7 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Suf PF05843.9 CDI81514.1 - 0.00054 19.7 18.8 0.00054 19.7 13.1 2.3 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) Band_3_cyto PF07565.8 CDI81514.1 - 0.0025 17.3 6.4 0.0025 17.3 4.4 2.2 2 0 0 2 2 2 1 Band 3 cytoplasmic domain SPX PF03105.14 CDI81514.1 - 0.24 11.1 12.5 0.086 12.6 4.5 2.1 2 0 0 2 2 2 0 SPX domain Herpes_UL87 PF03043.9 CDI81514.1 - 0.38 9.0 10.7 0.26 9.6 3.0 2.2 2 0 0 2 2 2 0 Herpesvirus UL87 family DUF2052 PF09747.4 CDI81514.1 - 0.43 10.4 24.9 1.9 8.3 0.2 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CD20 PF04103.10 CDI81514.1 - 1.1 9.1 10.6 4.9 7.0 0.1 3.3 3 0 0 3 3 3 0 CD20-like family SOBP PF15279.1 CDI81514.1 - 1.2 9.4 19.1 0.3 11.4 8.7 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein Neur_chan_memb PF02932.11 CDI81514.1 - 2 8.2 9.7 0.69 9.7 3.8 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S49_N PF08496.5 CDI81514.1 - 2.1 8.1 20.9 9.8 5.9 10.7 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal AUX_IAA PF02309.11 CDI81514.1 - 2.9 7.5 14.2 1.4 8.6 7.2 2.0 2 0 0 2 2 2 0 AUX/IAA family CPSF100_C PF13299.1 CDI81514.1 - 5.2 7.2 18.8 10 6.2 10.0 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FLO_LFY PF01698.11 CDI81514.1 - 6 5.6 18.0 2.7 6.7 9.6 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein eIF-3_zeta PF05091.7 CDI81514.1 - 6.5 5.2 21.8 0.52 8.8 10.7 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.10 CDI81514.1 - 6.8 5.2 14.8 2.5 6.7 7.0 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) FNIP_N PF14636.1 CDI81514.1 - 6.8 7.1 19.7 6 7.3 9.8 2.6 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus YjgP_YjgQ PF03739.9 CDI81514.1 - 9 4.9 12.7 1 8.0 3.4 2.7 3 0 0 3 3 3 0 Predicted permease YjgP/YjgQ family Topoisom_I PF01028.15 CDI81516.1 - 1.1e-89 299.6 16.5 1.1e-89 299.6 11.4 2.2 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 CDI81516.1 - 1.2e-22 79.2 0.3 1.2e-22 79.2 0.2 2.3 2 0 0 2 2 2 1 C-terminal topoisomerase domain Topoisom_I_N PF02919.10 CDI81516.1 - 6.6e-18 64.7 0.0 6.6e-18 64.7 0.0 4.4 2 2 1 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Nse4_C PF08743.5 CDI81516.1 - 0.013 15.4 0.5 0.065 13.2 0.3 2.2 1 0 0 1 1 1 0 Nse4 C-terminal PBP_like PF12727.2 CDI81516.1 - 0.21 10.4 3.8 0.39 9.6 2.6 1.4 1 0 0 1 1 1 0 PBP superfamily domain DUF3138 PF11336.3 CDI81516.1 - 0.22 9.6 11.0 0.23 9.5 6.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Ribosomal_60s PF00428.14 CDI81516.1 - 1.3 9.5 22.5 2.2 8.7 14.7 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Hist_deacetyl PF00850.14 CDI81517.1 - 2.9e-72 243.6 0.2 3.5e-72 243.3 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF3446 PF11928.3 CDI81517.1 - 0.16 12.2 9.5 0.31 11.2 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) SR-25 PF10500.4 CDI81517.1 - 2.7 7.4 15.1 4.2 6.7 10.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Hid1 PF12722.2 CDI81519.1 - 6.1e-06 24.2 0.1 6.1e-06 24.2 0.1 3.6 1 1 2 3 3 3 1 High-temperature-induced dauer-formation protein Dicty_REP PF05086.7 CDI81519.1 - 0.033 11.9 23.4 0.042 11.6 16.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PAT1 PF09770.4 CDI81519.1 - 0.037 12.2 76.8 0.047 11.9 53.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PLRV_ORF5 PF01690.12 CDI81519.1 - 0.039 13.1 32.2 0.048 12.7 22.3 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein MMR1 PF08505.5 CDI81519.1 - 0.19 11.7 40.7 0.33 10.9 28.2 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.8 CDI81519.1 - 0.69 9.7 56.9 1 9.1 39.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GAGA_bind PF06217.7 CDI81519.1 - 8.4 6.2 34.9 14 5.5 24.2 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family ketoacyl-synt PF00109.21 CDI81520.1 - 1.2e-78 264.1 0.0 3.9e-78 262.4 0.0 1.9 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CDI81520.1 - 2.2e-57 193.6 0.0 5e-57 192.4 0.0 1.7 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.16 CDI81520.1 - 1.9e-50 172.0 0.2 3.3e-50 171.2 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain adh_short PF00106.20 CDI81520.1 - 8.9e-49 165.6 0.3 9.4e-48 162.2 0.0 2.7 3 0 0 3 3 3 1 short chain dehydrogenase PS-DH PF14765.1 CDI81520.1 - 2.3e-48 164.8 0.4 3.5e-48 164.2 0.3 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CDI81520.1 - 2.7e-41 140.1 0.1 6.2e-41 138.9 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 CDI81520.1 - 2.5e-12 46.8 0.0 6.1e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N PF00107.21 CDI81520.1 - 9.9e-12 44.5 0.0 8.7e-11 41.4 0.0 2.8 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDI81520.1 - 1.8e-07 30.9 2.0 2.4e-06 27.2 1.4 2.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.16 CDI81520.1 - 9.1e-05 21.9 0.0 0.00021 20.7 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CDI81520.1 - 0.0036 17.1 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.18 CDI81520.1 - 0.0078 15.2 0.0 0.017 14.0 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ADH_zinc_N_2 PF13602.1 CDI81520.1 - 0.013 16.4 0.0 0.13 13.1 0.0 2.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Glyco_hydro_17 PF00332.13 CDI81522.1 - 1.8e-13 50.2 0.4 7.1e-08 31.8 0.0 3.6 3 0 0 3 3 3 2 Glycosyl hydrolases family 17 FimP PF09766.4 CDI81522.1 - 0.004 16.2 9.8 0.004 16.2 6.8 3.6 2 1 1 3 3 3 1 Fms-interacting protein Phytoreo_Pns PF05451.6 CDI81522.1 - 7.7 5.0 8.3 0.098 11.2 0.6 1.6 2 0 0 2 2 2 0 Phytoreovirus nonstructural protein Pns10/11 CPW_WPC PF09717.5 CDI81523.1 - 3.8e-45 152.3 24.2 1.2e-14 54.6 4.3 5.3 5 0 0 5 5 5 5 Plasmodium falciparum domain of unknown function (CPW_WPC) Tme5_EGF_like PF09064.5 CDI81523.1 - 3.3 7.4 15.9 0.31 10.6 0.5 3.9 4 1 0 4 4 4 0 Thrombomodulin like fifth domain, EGF-like UMP1 PF05348.6 CDI81524.1 - 0.078 12.9 3.3 0.1 12.5 2.3 1.0 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 Cpn60_TCP1 PF00118.19 CDI81531.1 - 7.1e-72 242.5 0.1 7.9e-72 242.4 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TMEM51 PF15345.1 CDI81533.1 - 0.064 12.9 1.7 0.17 11.5 0.0 2.0 1 1 1 2 2 2 0 Transmembrane protein 51 OAD_gamma PF04277.8 CDI81533.1 - 0.22 11.9 1.7 5.1 7.5 0.0 2.6 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain PBP1_TM PF14812.1 CDI81533.1 - 0.42 10.9 8.7 2.6 8.4 0.0 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3138 PF11336.3 CDI81533.1 - 1.3 7.1 8.4 1.7 6.6 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Nucleoplasmin PF03066.10 CDI81533.1 - 1.6 8.1 7.6 2.1 7.8 1.4 2.2 2 0 0 2 2 2 0 Nucleoplasmin MIP-T3 PF10243.4 CDI81534.1 - 0.01 14.3 0.2 0.5 8.7 0.1 2.0 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 LXG PF04740.7 CDI81534.1 - 0.048 13.4 0.4 0.083 12.6 0.3 1.3 1 0 0 1 1 1 0 LXG domain of WXG superfamily CK2S PF15011.1 CDI81534.1 - 0.076 12.7 0.9 0.32 10.7 0.6 1.8 1 1 0 1 1 1 0 Casein Kinase 2 substrate FliT PF05400.8 CDI81534.1 - 0.35 11.3 3.6 2.6 8.4 2.5 2.1 1 1 0 1 1 1 0 Flagellar protein FliT SPATA6 PF14909.1 CDI81535.1 - 0.19 11.7 0.0 0.42 10.6 0.0 1.4 1 0 0 1 1 1 0 Spermatogenesis-assoc protein 6 F-box PF00646.28 CDI81536.1 - 0.015 14.9 0.2 0.046 13.3 0.1 1.9 1 0 0 1 1 1 0 F-box domain AAA_23 PF13476.1 CDI81539.1 - 6.2 7.0 19.9 9.7 6.4 13.8 1.2 1 0 0 1 1 1 0 AAA domain TSP_1 PF00090.14 CDI81540.1 - 4.6e-07 29.8 19.3 0.0017 18.4 3.7 3.0 2 0 0 2 2 2 2 Thrombospondin type 1 domain DUF1900 PF08954.6 CDI81544.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1900) DAN PF03045.10 CDI81544.1 - 0.18 11.2 4.8 0.082 12.3 0.8 2.3 2 0 0 2 2 2 0 DAN domain Vwaint PF14624.1 CDI81547.1 - 0.072 13.1 0.6 0.072 13.1 0.4 2.1 2 1 0 2 2 2 0 VWA / Hh protein intein-like DUF4164 PF13747.1 CDI81547.1 - 3.2 7.9 11.8 0.82 9.8 0.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Cor1 PF04803.7 CDI81547.1 - 5.1 6.8 15.0 0.16 11.7 2.8 2.3 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region DivIVA PF05103.8 CDI81547.1 - 6.4 6.8 9.8 7.1 6.6 1.8 2.4 2 1 0 2 2 2 0 DivIVA protein Fib_alpha PF08702.5 CDI81547.1 - 9 6.4 8.4 1.3 9.1 1.1 2.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family tRNA-synt_1c PF00749.16 CDI81549.1 - 3.5e-66 223.0 0.4 6.4e-34 117.0 0.0 4.2 4 0 0 4 4 4 3 tRNA synthetases class I (E and Q), catalytic domain DAGK_cat PF00781.19 CDI81551.1 - 1.7e-18 66.2 0.2 2e-11 43.4 0.0 3.5 3 0 0 3 3 3 2 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.14 CDI81551.1 - 6.4e-16 58.9 7.6 6.1e-11 42.7 0.0 3.1 3 0 0 3 3 3 2 Diacylglycerol kinase accessory domain BAF1_ABF1 PF04684.8 CDI81551.1 - 4.5e-05 22.4 13.6 4.5e-05 22.4 9.5 7.6 4 2 3 7 7 7 1 BAF1 / ABF1 chromatin reorganising factor MarC PF01914.12 CDI81551.1 - 0.067 12.2 0.0 0.3 10.1 0.0 2.1 1 0 0 1 1 1 0 MarC family integral membrane protein Sec7_N PF12783.2 CDI81555.1 - 0.0046 16.3 3.3 0.0046 16.3 2.3 2.3 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Ribosomal_L6 PF00347.18 CDI81558.1 - 1.8e-25 89.2 0.5 1.8e-13 50.7 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Syntaxin PF00804.20 CDI81559.1 - 0.016 15.3 1.7 0.026 14.6 1.2 1.3 1 0 0 1 1 1 0 Syntaxin Orbi_VP5 PF00901.12 CDI81559.1 - 0.019 13.1 0.6 0.026 12.7 0.4 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 DUF972 PF06156.8 CDI81559.1 - 0.046 14.0 2.9 0.073 13.4 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF2400 PF09674.5 CDI81559.1 - 0.078 12.6 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) NYD-SP28 PF14772.1 CDI81559.1 - 0.1 12.7 5.3 0.17 11.9 3.7 1.3 1 0 0 1 1 1 0 Sperm tail HJURP_C PF12347.3 CDI81559.1 - 0.27 10.8 2.2 1.1 8.8 0.9 2.3 1 1 1 2 2 2 0 Holliday junction regulator protein family C-terminal repeat Fib_alpha PF08702.5 CDI81559.1 - 0.32 11.1 4.3 0.54 10.3 3.0 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MCPVI PF02993.9 CDI81559.1 - 0.7 10.0 4.3 0.44 10.6 1.6 1.6 2 0 0 2 2 2 0 Minor capsid protein VI CAF-1_p150 PF11600.3 CDI81560.1 - 0.13 11.6 11.4 0.19 11.0 7.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal GET2 PF08690.5 CDI81560.1 - 1.9 7.6 6.3 3 6.9 4.3 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4551 PF15087.1 CDI81560.1 - 2.1 6.6 10.5 3.2 6.0 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Peptidase_S8 PF00082.17 CDI81563.1 - 6.2e-31 107.5 9.2 8.6e-25 87.4 2.1 4.7 2 2 2 4 4 4 2 Subtilase family DUF566 PF04484.7 CDI81563.1 - 0.76 9.2 43.4 0.025 14.0 18.7 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF566) DnaJ PF00226.26 CDI81564.1 - 5.4e-26 90.1 3.9 8.9e-26 89.4 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CDI81564.1 - 1.3e-24 85.9 0.7 1.6e-23 82.3 0.1 2.5 3 0 0 3 3 3 1 DnaJ C terminal domain Claudin_2 PF13903.1 CDI81564.1 - 0.0024 17.6 2.1 0.0034 17.1 1.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Myb_DNA-binding PF00249.26 CDI81566.1 - 0.00031 20.7 0.0 0.00068 19.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain EF-hand_7 PF13499.1 CDI81568.1 - 2.6e-19 69.0 0.5 4.3e-13 49.1 0.4 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI81568.1 - 2.1e-18 64.1 0.2 4.1e-06 25.7 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 CDI81568.1 - 4.8e-16 57.1 1.2 2.8e-06 26.7 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 CDI81568.1 - 3.8e-13 48.8 0.4 1.3e-05 24.7 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 CDI81568.1 - 1.4e-12 46.3 0.7 5e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 CDI81568.1 - 0.00043 20.1 0.1 0.035 14.0 0.1 2.6 2 1 0 2 2 2 1 EF-hand domain DUF1880 PF08976.6 CDI81568.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1880) Caleosin PF05042.8 CDI81568.1 - 0.028 13.9 0.0 0.9 9.0 0.0 2.2 2 0 0 2 2 2 0 Caleosin related protein SPARC_Ca_bdg PF10591.4 CDI81568.1 - 0.033 14.2 0.0 0.059 13.3 0.0 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region MHCassoc_trimer PF08831.5 CDI81568.1 - 0.049 13.4 0.5 0.3 10.9 0.3 2.1 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain MotA_activ PF09114.5 CDI81568.1 - 0.086 12.5 0.2 0.88 9.3 0.1 2.0 1 1 1 2 2 2 0 Transcription factor MotA, activation domain EF-hand_like PF09279.6 CDI81568.1 - 0.11 12.4 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like PAT1 PF09770.4 CDI81573.1 - 2.4 6.3 54.1 4.2 5.4 37.5 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Fasciclin PF02469.17 CDI81574.1 - 5.2e-07 29.7 0.0 2.2e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 Fasciclin domain DUF4404 PF14357.1 CDI81576.1 - 0.09 13.1 0.4 45 4.5 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Notch PF00066.12 CDI81577.1 - 2.1e-51 171.8 105.8 1.4e-09 38.0 10.6 6.2 5 1 1 6 6 6 6 LNR domain AAA_12 PF13087.1 CDI81579.1 - 8.2e-05 22.0 0.7 8.2e-05 22.0 0.5 1.8 2 0 0 2 2 2 1 AAA domain Shadoo PF14999.1 CDI81579.1 - 0.027 14.3 5.8 0.048 13.5 4.0 1.3 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective U79_P34 PF03064.11 CDI81579.1 - 0.1 12.0 4.6 0.17 11.4 3.2 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Nucleo_P87 PF07267.6 CDI81579.1 - 1.5 7.4 5.3 1.9 7.0 3.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Tim54 PF11711.3 CDI81579.1 - 3.3 6.2 10.7 0.4 9.2 4.2 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DNA_pol_delta_4 PF04081.8 CDI81580.1 - 8.6e-17 61.5 0.0 1.3e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 Shadoo PF14999.1 CDI81580.1 - 0.081 12.7 1.9 0.26 11.1 1.3 1.8 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Med3 PF11593.3 CDI81580.1 - 0.17 11.0 4.3 0.18 11.0 3.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Na_trans_assoc PF06512.8 CDI81581.1 - 0.0077 16.2 4.3 0.011 15.7 3.0 1.1 1 0 0 1 1 1 1 Sodium ion transport-associated Bud13 PF09736.4 CDI81581.1 - 0.67 10.2 7.2 1 9.6 5.0 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF572 PF04502.8 CDI81581.1 - 0.82 8.8 9.5 1.1 8.3 6.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF1675 PF07897.6 CDI81581.1 - 3.6 7.3 9.5 4.8 6.9 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) FAM176 PF14851.1 CDI81582.1 - 0.054 13.1 0.1 0.057 13.1 0.0 1.0 1 0 0 1 1 1 0 FAM176 family PulG PF11773.3 CDI81582.1 - 0.13 11.9 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin Pkinase PF00069.20 CDI81583.1 - 3.3e-18 65.7 0.0 2.1e-17 63.1 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 CDI81583.1 - 2e-10 40.0 0.0 3.1e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI81583.1 - 2.6e-09 36.5 0.0 5.8e-09 35.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 CDI81583.1 - 0.006 15.6 0.0 0.012 14.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDI81583.1 - 0.094 12.4 1.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Chorion_2 PF03964.10 CDI81583.1 - 2.4 8.7 11.9 0.99 9.9 3.4 2.6 2 0 0 2 2 2 0 Chorion family 2 DEAD PF00270.24 CDI81584.1 - 1.8e-08 34.0 0.0 1.8e-08 34.0 0.0 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase SR-25 PF10500.4 CDI81584.1 - 0.51 9.7 28.9 0.029 13.8 4.7 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ycf1 PF05758.7 CDI81584.1 - 0.65 7.6 11.5 0.86 7.2 8.0 1.1 1 0 0 1 1 1 0 Ycf1 ResIII PF04851.10 CDI81584.1 - 1 9.1 0.0 1 9.1 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Hid1 PF12722.2 CDI81584.1 - 1.1 6.8 17.3 1.4 6.5 12.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.10 CDI81584.1 - 7.4 5.0 17.4 10 4.6 12.0 1.3 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein ketoacyl-synt PF00109.21 CDI81585.1 - 2.2e-80 269.7 0.5 5.6e-80 268.4 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CDI81585.1 - 3.7e-52 177.6 1.4 9e-52 176.3 0.1 2.0 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.1 CDI81585.1 - 7.3e-46 156.6 2.2 1.3e-45 155.8 1.6 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CDI81585.1 - 5.9e-39 132.5 0.1 1.5e-38 131.2 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.5 CDI81585.1 - 7.7e-39 133.2 0.5 3.9e-38 130.9 0.1 2.3 2 0 0 2 2 2 1 KR domain adh_short PF00106.20 CDI81585.1 - 6.1e-28 97.8 1.2 3.1e-27 95.5 0.0 2.9 3 0 0 3 3 3 1 short chain dehydrogenase ADH_zinc_N PF00107.21 CDI81585.1 - 5e-17 61.6 0.0 1.2e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CDI81585.1 - 5.5e-14 52.1 0.0 1.5e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.7 CDI81585.1 - 1.6e-06 27.7 4.9 6.4e-06 25.8 0.2 3.2 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.18 CDI81585.1 - 0.0053 15.7 0.1 0.013 14.4 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain efThoc1 PF11957.3 CDI81585.1 - 0.12 10.8 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor PT PF04886.7 CDI81590.1 - 0.015 14.5 8.7 0.015 14.5 6.0 5.3 2 1 2 4 4 4 0 PT repeat zf-CCCH PF00642.19 CDI81591.1 - 1.2e-09 37.6 14.7 6.2e-05 22.5 0.9 3.7 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) EF1_GNE PF00736.14 CDI81592.1 - 4.9e-24 83.8 0.7 4.9e-24 83.8 0.5 1.9 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain Glycoprotein PF03409.10 CDI81592.1 - 0.052 12.2 0.2 0.069 11.8 0.1 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein Polysacc_synt_2 PF02719.10 CDI81592.1 - 0.12 11.3 0.5 0.19 10.6 0.3 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein NOA36 PF06524.7 CDI81592.1 - 0.12 11.5 0.1 0.12 11.5 0.0 2.1 1 1 1 2 2 2 0 NOA36 protein Telomere_Sde2_2 PF13297.1 CDI81593.1 - 0.066 12.4 0.2 0.16 11.2 0.1 1.6 1 0 0 1 1 1 0 Telomere stability C-terminal DUF966 PF06136.8 CDI81596.1 - 0.0069 15.8 2.3 0.0069 15.8 1.6 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF966) BTB_2 PF02214.17 CDI81596.1 - 0.053 13.7 0.0 0.19 11.9 0.0 2.0 1 1 0 1 1 1 0 BTB/POZ domain ketoacyl-synt PF00109.21 CDI81597.1 - 1.7e-77 260.3 0.1 3.1e-77 259.4 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.5 CDI81597.1 - 2.3e-71 239.2 0.0 1.3e-37 129.2 0.0 2.5 2 0 0 2 2 2 2 KR domain adh_short PF00106.20 CDI81597.1 - 3.7e-58 196.1 0.0 2.6e-28 99.0 0.0 2.7 2 0 0 2 2 2 2 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CDI81597.1 - 5.8e-43 145.5 0.1 1.2e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.1 CDI81597.1 - 3.7e-39 134.6 0.6 5.7e-39 134.0 0.4 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N PF00107.21 CDI81597.1 - 5.4e-15 55.0 0.0 1.3e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CDI81597.1 - 1e-11 44.9 0.0 2.2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.1 CDI81597.1 - 4.5e-08 34.0 0.0 1.9e-07 32.0 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDI81597.1 - 1.5e-06 27.9 3.6 1.7e-06 27.7 0.1 2.8 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.16 CDI81597.1 - 2.9e-05 23.6 0.0 0.00035 20.0 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CDI81597.1 - 0.00025 20.8 0.0 0.058 13.1 0.0 2.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 CDI81597.1 - 0.00074 18.4 0.0 0.0015 17.4 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CDI81597.1 - 0.0034 16.1 0.0 0.017 13.8 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.18 CDI81597.1 - 0.01 14.8 0.5 0.031 13.2 0.1 1.9 2 0 0 2 2 2 0 Thiolase, N-terminal domain AlaDh_PNT_C PF01262.16 CDI81597.1 - 0.048 13.2 0.1 0.16 11.5 0.1 1.8 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.16 CDI81597.1 - 0.17 11.4 1.5 2 7.9 0.0 2.3 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Spt20 PF12090.3 CDI81598.1 - 0.1 11.9 6.0 0.088 12.1 4.1 1.1 1 0 0 1 1 1 0 Spt20 family RAB3GAP2_N PF14655.1 CDI81598.1 - 0.77 8.6 7.4 0.72 8.7 5.1 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Med15 PF09606.5 CDI81598.1 - 0.88 7.6 23.2 0.81 7.8 16.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF788 PF05620.6 CDI81598.1 - 1.9 8.3 6.9 2.1 8.1 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF788) DUF3371 PF11851.3 CDI81598.1 - 2.1 9.0 13.5 2.5 8.8 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) SHR3_chaperone PF08229.6 CDI81598.1 - 2.4 7.0 5.0 2.5 7.0 3.5 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Suf PF05843.9 CDI81598.1 - 3.1 7.4 10.6 2.9 7.5 7.4 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3154 PF11351.3 CDI81598.1 - 5.4 6.7 6.2 7 6.4 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3154) EF-1_beta_acid PF10587.4 CDI81599.1 - 1.2 9.3 4.5 4.6 7.4 3.1 2.1 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Thioredoxin PF00085.15 CDI81603.1 - 6.4e-07 29.0 0.0 3.1e-05 23.5 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.1 CDI81603.1 - 1.2e-06 28.4 0.0 1.8e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin-like domain C2 PF00168.25 CDI81605.1 - 3.1e-12 46.1 0.1 1e-09 38.0 0.0 3.2 3 0 0 3 3 3 1 C2 domain Dehydrin PF00257.14 CDI81606.1 - 0.019 15.2 3.6 0.019 15.2 2.5 5.5 4 1 0 4 4 4 0 Dehydrin MAGE_N PF12440.3 CDI81607.1 - 0.0051 17.0 6.2 0.0051 17.0 4.3 1.7 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal Ion_trans PF00520.26 CDI81609.1 - 5.6e-06 25.7 4.9 8.7e-06 25.1 3.4 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 CDI81609.1 - 0.052 11.9 2.3 0.07 11.5 1.6 1.1 1 0 0 1 1 1 0 Polycystin cation channel RFC1 PF08519.7 CDI81610.1 - 1.2e-11 44.6 0.1 2.2e-06 27.5 0.0 2.2 1 1 1 2 2 2 2 Replication factor RFC1 C terminal domain RNase_H2-Ydr279 PF09468.5 CDI81610.1 - 0.021 14.0 0.1 0.023 13.8 0.1 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) LNP1 PF15419.1 CDI81610.1 - 0.028 14.5 1.8 0.046 13.8 1.0 1.5 1 1 0 1 1 1 0 Leukemia NUP98 fusion partner 1 TBX PF12598.3 CDI81610.1 - 1.1 9.6 7.4 0.075 13.4 1.3 1.8 2 0 0 2 2 2 0 T-box transcription factor Helicase_C PF00271.26 CDI81614.1 - 2.1e-13 49.9 2.3 3.3e-13 49.2 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain PTCB-BRCT PF12738.2 CDI81616.1 - 4e-06 26.5 0.1 7.5e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 CDI81616.1 - 5.6e-06 26.4 0.0 1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain MRI PF15325.1 CDI81616.1 - 9.5 7.2 18.9 0.15 13.0 5.9 2.5 2 0 0 2 2 2 0 Modulator of retrovirus infection Beta-lactamase2 PF13354.1 CDI81618.1 - 8.7e-39 133.0 0.0 1.1e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase enzyme family Beta-lactamase PF00144.19 CDI81618.1 - 5.6e-30 104.4 0.0 1.1e-29 103.5 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.15 CDI81618.1 - 1.3e-08 34.4 0.0 3.3e-08 33.1 0.0 1.6 1 1 1 2 2 2 1 D-alanyl-D-alanine carboxypeptidase GFP PF01353.17 CDI81619.1 - 3e-65 219.6 0.4 3.5e-65 219.4 0.3 1.0 1 0 0 1 1 1 1 Green fluorescent protein RNA_pol_Rpb2_6 PF00562.23 CDI81621.1 - 1e-115 386.6 0.0 1.3e-115 386.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.15 CDI81621.1 - 3.5e-18 65.6 0.0 7.1e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.11 CDI81621.1 - 0.0038 16.9 0.0 0.0087 15.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 NUC153 PF08159.7 CDI81622.1 - 3.3e-06 26.5 0.1 6.9e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 NUC153 domain TFIIA PF03153.8 CDI81623.1 - 1 9.2 6.2 1.9 8.3 4.3 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ORC6 PF05460.8 CDI81625.1 - 2.6 7.0 6.8 3.3 6.7 4.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) CD20 PF04103.10 CDI81627.1 - 0.045 13.6 1.5 13 5.7 0.0 3.5 4 1 0 4 4 4 0 CD20-like family DUF3573 PF12097.3 CDI81627.1 - 1.2 7.7 7.7 3.3 6.2 5.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) GATase PF00117.23 CDI81629.1 - 8.6e-22 77.5 0.0 4.4e-21 75.2 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CDI81629.1 - 2.7e-06 26.9 0.0 5.1e-05 22.8 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 Asn_synthase PF00733.16 CDI81629.1 - 5.2e-06 26.1 0.1 1.5e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Asparagine synthase NAD_synthase PF02540.12 CDI81629.1 - 1.3e-05 24.2 0.0 2.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.11 CDI81629.1 - 0.0012 17.4 0.0 0.0017 16.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.9 CDI81629.1 - 0.025 14.0 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.14 CDI81629.1 - 0.1 11.6 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Arginosuccinate synthase FliE PF02049.13 CDI81631.1 - 0.12 12.3 1.6 2.3 8.3 0.7 2.6 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE DUF2564 PF10819.3 CDI81631.1 - 0.25 11.4 4.7 0.15 12.1 1.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2564) MIP-T3 PF10243.4 CDI81637.1 - 0.024 13.1 59.3 0.032 12.7 41.1 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PAT1 PF09770.4 CDI81637.1 - 4.1 5.5 64.7 5.3 5.1 44.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Utp14 PF04615.8 CDI81637.1 - 5 5.1 61.0 8.2 4.4 42.3 1.3 1 0 0 1 1 1 0 Utp14 protein UPF0172 PF03665.8 CDI81638.1 - 2e-16 60.0 0.2 1.2e-14 54.2 0.1 2.1 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.16 CDI81638.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Med15 PF09606.5 CDI81642.1 - 0.00029 19.2 66.1 0.00029 19.2 45.8 3.8 3 1 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.4 CDI81642.1 - 0.0036 16.8 2.3 0.0036 16.8 1.6 7.7 7 1 0 7 7 7 1 Nuclear RNA-splicing-associated protein BPL_LplA_LipB PF03099.14 CDI81642.1 - 0.055 13.4 0.0 4.9 7.1 0.0 2.7 2 0 0 2 2 2 0 Biotin/lipoate A/B protein ligase family Diacid_rec PF05651.8 CDI81642.1 - 0.13 11.7 0.0 0.13 11.7 0.0 4.3 5 0 0 5 5 5 0 Putative sugar diacid recognition Peptidase_S49_N PF08496.5 CDI81642.1 - 3.6 7.3 25.3 9.9 5.9 2.1 4.6 4 0 0 4 4 4 0 Peptidase family S49 N-terminal Cwf_Cwc_15 PF04889.7 CDI81643.1 - 0.0039 16.9 10.0 0.0072 16.0 6.9 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Hid1 PF12722.2 CDI81643.1 - 1.5 6.3 12.7 1.7 6.2 8.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3337 PF11816.3 CDI81643.1 - 4.3 6.6 17.3 7.2 5.8 12.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) SPATIAL PF15256.1 CDI81643.1 - 7 6.6 12.0 8.8 6.3 7.8 1.5 1 1 0 1 1 1 0 SPATIAL MFS_1 PF07690.11 CDI81644.1 - 2.3e-14 52.9 43.7 1.6e-11 43.5 15.4 3.0 3 2 0 3 3 3 2 Major Facilitator Superfamily DUF3775 PF12616.3 CDI81644.1 - 0.00098 18.8 0.6 0.91 9.3 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3775) EphA2_TM PF14575.1 CDI81644.1 - 0.1 12.9 0.0 33 4.9 0.0 2.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CAF-1_p150 PF11600.3 CDI81646.1 - 0.043 13.1 16.6 0.054 12.8 11.5 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Med15 PF09606.5 CDI81646.1 - 0.45 8.6 68.9 0.53 8.4 47.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Dala_Dala_lig_N PF01820.16 CDI81646.1 - 1.3 9.3 13.4 9.6 6.5 9.3 2.0 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus DUF342 PF03961.8 CDI81646.1 - 1.7 6.9 16.3 2 6.7 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SprA-related PF12118.3 CDI81646.1 - 3.7 6.7 38.7 5.4 6.2 26.8 1.2 1 0 0 1 1 1 0 SprA-related family PAT1 PF09770.4 CDI81646.1 - 5.7 5.0 58.4 6.6 4.8 40.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3617 PF12276.3 CDI81647.1 - 1 8.7 17.1 2.1 7.7 11.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3617) HEPPP_synt_1 PF07307.6 CDI81647.1 - 1.3 8.4 8.7 0.24 10.8 3.3 1.7 1 1 1 2 2 2 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 TFIIA PF03153.8 CDI81647.1 - 2.4 7.9 28.6 3.1 7.6 19.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Bac_luciferase PF00296.15 CDI81647.1 - 3 6.8 21.3 4.2 6.4 14.5 1.5 1 1 0 1 1 1 0 Luciferase-like monooxygenase AAA_23 PF13476.1 CDI81647.1 - 5.2 7.3 11.0 6.9 6.9 7.7 1.2 1 0 0 1 1 1 0 AAA domain APG17 PF04108.7 CDI81650.1 - 0.0028 16.5 0.9 0.0037 16.1 0.7 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 Lzipper-MIP1 PF14389.1 CDI81650.1 - 0.013 15.6 0.4 0.013 15.6 0.3 2.1 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF869 PF05911.6 CDI81650.1 - 0.033 12.4 9.5 0.043 12.0 6.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF1908 PF08926.6 CDI81650.1 - 0.054 12.2 8.5 0.084 11.6 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) BBP1_C PF15272.1 CDI81650.1 - 0.24 10.9 5.8 0.74 9.3 4.0 1.7 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal COG7 PF10191.4 CDI81650.1 - 1.2 6.9 10.9 0.25 9.1 1.6 2.0 1 1 1 2 2 2 0 Golgi complex component 7 (COG7) PPDFL PF15060.1 CDI81650.1 - 1.5 8.8 9.8 1.9 8.5 0.5 2.7 2 0 0 2 2 2 0 Differentiation and proliferation regulator Striatin PF08232.7 CDI81650.1 - 2.6 8.3 8.7 7.4 6.8 5.1 2.2 1 1 1 2 2 2 0 Striatin family SlyX PF04102.7 CDI81650.1 - 2.6 8.4 5.5 12 6.4 0.2 2.7 1 1 1 2 2 2 0 SlyX Fmp27_WPPW PF10359.4 CDI81650.1 - 4.6 5.5 6.5 6.1 5.1 4.5 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Lipocalin_5 PF13924.1 CDI81653.1 - 0.86 9.2 5.8 4.8 6.8 0.1 3.8 2 1 1 3 3 3 0 Lipocalin-like domain DUF4616 PF15394.1 CDI81655.1 - 0.00087 18.4 2.4 0.00096 18.2 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4616) EutA PF06277.6 CDI81655.1 - 0.087 11.4 0.4 0.12 10.9 0.2 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA Cyto_heme_lyase PF01265.12 CDI81655.1 - 0.71 9.4 6.8 0.84 9.1 4.7 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase MCM PF00493.18 CDI81658.1 - 1.1e-57 195.3 0.2 1.4e-57 195.0 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase_2 PF13335.1 CDI81658.1 - 0.033 14.5 2.9 0.13 12.6 0.2 3.0 3 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 CDI81658.1 - 0.05 13.2 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 CDI81658.1 - 0.064 12.4 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NGP1NT PF08153.7 CDI81663.1 - 5.3e-35 120.1 0.3 3.2e-34 117.6 0.0 2.3 2 1 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 CDI81663.1 - 8.1e-17 61.2 0.0 6.3e-14 51.9 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 CDI81663.1 - 4.4e-05 22.8 0.0 0.007 15.6 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDI81663.1 - 0.00012 21.5 0.1 0.0026 17.2 0.0 2.5 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.16 CDI81663.1 - 0.00038 19.7 0.0 0.67 9.1 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF258 PF03193.11 CDI81663.1 - 0.0013 17.9 0.0 0.0025 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CDI81663.1 - 0.021 14.6 0.3 3.5 7.3 0.0 3.0 2 1 1 3 3 3 0 Dynamin family Lactamase_B PF00753.22 CDI81664.1 - 2.6e-06 27.2 0.0 3.4e-05 23.5 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CDI81664.1 - 0.0014 18.2 0.1 0.0031 17.0 0.0 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain SAGA-Tad1 PF12767.2 CDI81665.1 - 0.004 16.8 14.7 0.004 16.8 10.2 5.8 6 0 0 6 6 6 2 Transcriptional regulator of RNA polII, SAGA, subunit ApoA-II PF04711.8 CDI81670.1 - 0.087 12.7 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) DUF4647 PF15504.1 CDI81676.1 - 0.00023 20.1 2.8 0.00024 20.1 2.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) SAPS PF04499.10 CDI81676.1 - 0.012 14.2 0.8 0.012 14.2 0.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ERM PF00769.14 CDI81676.1 - 0.013 15.0 18.0 0.017 14.6 12.5 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF966 PF06136.8 CDI81676.1 - 0.052 12.9 8.7 0.061 12.7 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Oxidored_q1_N PF00662.15 CDI81676.1 - 0.07 12.6 0.6 0.14 11.7 0.4 1.4 1 0 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus HNOBA PF07701.9 CDI81676.1 - 0.11 11.6 2.8 0.21 10.7 1.9 1.4 1 0 0 1 1 1 0 Heme NO binding associated Hid1 PF12722.2 CDI81676.1 - 0.23 9.1 4.4 0.25 8.9 3.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4557 PF15101.1 CDI81676.1 - 0.36 10.6 10.6 0.63 9.8 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Band_3_cyto PF07565.8 CDI81676.1 - 0.45 9.9 5.3 0.67 9.4 3.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FCP1_C PF09309.5 CDI81676.1 - 0.68 9.1 8.5 1 8.5 5.9 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Neur_chan_memb PF02932.11 CDI81676.1 - 0.71 9.7 3.6 0.96 9.2 2.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S64 PF08192.6 CDI81676.1 - 1 7.5 7.5 1.2 7.3 5.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 PIH1 PF08190.7 CDI81676.1 - 1.2 8.5 11.7 1.5 8.1 8.1 1.1 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 Otopetrin PF03189.8 CDI81676.1 - 1.3 7.9 3.6 1.7 7.5 2.5 1.2 1 0 0 1 1 1 0 Otopetrin TFIIA PF03153.8 CDI81676.1 - 2 8.2 19.4 2.5 7.8 13.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex16 PF08610.5 CDI81676.1 - 2.6 6.9 7.6 5.1 6.0 5.3 1.4 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) OATP PF03137.15 CDI81676.1 - 3 5.7 5.0 4.1 5.3 3.2 1.4 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BAF1_ABF1 PF04684.8 CDI81676.1 - 4.7 5.9 26.0 0.049 12.4 8.9 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PPP4R2 PF09184.6 CDI81676.1 - 9.1 5.7 10.9 12 5.2 7.6 1.1 1 0 0 1 1 1 0 PPP4R2 DUF2052 PF09747.4 CDI81676.1 - 9.7 6.0 14.2 14 5.5 9.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.12 CDI81676.1 - 9.7 4.8 7.5 12 4.6 5.2 1.3 1 0 0 1 1 1 0 Presenilin TMF_TATA_bd PF12325.3 CDI81678.1 - 0.24 11.1 6.5 0.61 9.8 4.5 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding YlqD PF11068.3 CDI81678.1 - 0.78 9.7 5.4 2 8.4 3.7 1.6 1 0 0 1 1 1 0 YlqD protein DivIC PF04977.10 CDI81678.1 - 5.1 6.6 6.8 4.8 6.7 0.1 2.4 2 0 0 2 2 2 0 Septum formation initiator rRNA_processing PF08524.6 CDI81680.1 - 4.9e-05 23.1 17.4 4.9e-05 23.1 12.1 3.9 3 1 1 4 4 4 1 rRNA processing Di19_C PF14571.1 CDI81680.1 - 0.015 15.5 2.4 0.015 15.5 1.6 3.4 4 0 0 4 4 4 0 Stress-induced protein Di19, C-terminal DUF1049 PF06305.6 CDI81682.1 - 0.1 12.1 0.1 0.29 10.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) DUF515 PF04415.7 CDI81682.1 - 0.31 9.2 6.0 0.66 8.1 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Macoilin PF09726.4 CDI81682.1 - 1.6 6.9 9.1 1.6 6.9 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein PCMT PF01135.14 CDI81685.1 - 1.7e-21 76.7 0.0 3.3e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF2793 PF10983.3 CDI81685.1 - 0.1 12.4 0.6 0.33 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2793) PCMT PF01135.14 CDI81686.1 - 6.6e-31 107.4 0.2 7.7e-27 94.1 0.1 2.1 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 CDI81686.1 - 0.045 13.4 0.2 0.096 12.3 0.0 1.5 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 CDI81686.1 - 0.091 12.3 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF566 PF04484.7 CDI81686.1 - 1.4 8.3 11.9 1.9 7.9 8.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) DUF3395 PF11875.3 CDI81687.1 - 5.1e-07 29.4 7.0 2.3e-06 27.2 4.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3395) DUF3595 PF12166.3 CDI81687.1 - 0.17 10.6 5.4 0.36 9.5 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) Med13_C PF06333.7 CDI81687.1 - 4 5.8 14.5 1.6 7.2 4.5 2.2 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal DUF2146 PF10220.4 CDI81687.1 - 4.2 5.2 6.3 9.4 4.0 4.4 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Nop14 PF04147.7 CDI81687.1 - 4.4 5.0 16.0 0.074 10.9 4.4 2.2 2 0 0 2 2 2 0 Nop14-like family Flavokinase PF01687.12 CDI81690.1 - 2.4e-09 37.1 0.0 5.9e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Riboflavin kinase Cas_Cas1 PF01867.11 CDI81690.1 - 3.5 6.6 6.7 0.2 10.7 0.4 2.0 2 0 0 2 2 2 0 CRISPR associated protein Cas1 Dynamin_N PF00350.18 CDI81692.1 - 2e-22 79.7 0.0 9.5e-22 77.5 0.0 1.8 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 CDI81692.1 - 2e-09 37.4 0.0 3.4e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDI81692.1 - 2.7e-06 26.9 0.0 0.0016 17.8 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 CDI81692.1 - 0.00018 22.0 0.0 0.0028 18.1 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 CDI81692.1 - 0.0025 16.9 0.0 0.0095 15.0 0.0 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 CDI81692.1 - 0.0026 17.2 0.0 0.7 9.3 0.0 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 CDI81692.1 - 0.003 17.5 0.0 0.0071 16.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 CDI81692.1 - 0.019 14.4 0.0 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 CDI81692.1 - 0.025 14.0 0.0 0.3 10.5 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.1 CDI81692.1 - 0.052 13.6 0.0 0.17 12.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain Septin PF00735.13 CDI81692.1 - 0.07 12.1 0.0 0.28 10.1 0.0 1.8 2 0 0 2 2 2 0 Septin Ras PF00071.17 CDI81692.1 - 0.1 11.9 0.0 11 5.3 0.0 2.2 2 0 0 2 2 2 0 Ras family MobB PF03205.9 CDI81692.1 - 0.11 12.1 0.0 0.38 10.4 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RIO1 PF01163.17 CDI81693.1 - 2.4e-42 144.4 0.2 4.7e-42 143.4 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 CDI81693.1 - 3.7e-08 33.3 8.2 6.5e-05 22.7 0.2 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 CDI81693.1 - 8e-07 28.3 0.2 1.3e-05 24.3 0.1 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 CDI81693.1 - 0.0012 18.1 0.1 0.0019 17.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) CDC37_C PF08564.5 CDI81694.1 - 0.12 12.2 0.2 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain DUF4393 PF14337.1 CDI81694.1 - 0.13 11.6 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4393) Pex14_N PF04695.8 CDI81696.1 - 0.003 17.5 1.7 0.003 17.5 1.2 2.5 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Gly-zipper_OmpA PF13436.1 CDI81696.1 - 0.0044 16.6 3.6 0.0044 16.6 2.5 2.6 3 0 0 3 3 3 1 Glycine-zipper containing OmpA-like membrane domain AAA_23 PF13476.1 CDI81696.1 - 0.031 14.6 3.0 0.042 14.1 2.1 1.1 1 0 0 1 1 1 0 AAA domain DUF106 PF01956.11 CDI81696.1 - 0.1 12.1 1.8 0.15 11.5 1.3 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF4407 PF14362.1 CDI81696.1 - 0.19 10.6 5.3 0.31 9.9 3.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cgr1 PF03879.9 CDI81696.1 - 0.29 11.3 14.7 0.47 10.6 10.2 1.2 1 0 0 1 1 1 0 Cgr1 family Pneumo_phosprot PF02478.11 CDI81696.1 - 0.33 10.4 4.2 0.65 9.4 2.9 1.4 1 0 0 1 1 1 0 Pneumovirus phosphoprotein DUF4175 PF13779.1 CDI81696.1 - 0.62 7.6 19.7 1.1 6.8 13.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RR_TM4-6 PF06459.7 CDI81696.1 - 2.3 8.0 8.4 3.7 7.3 5.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4557 PF15101.1 CDI81696.1 - 3.9 7.2 12.3 6.2 6.6 8.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) IncA PF04156.9 CDI81696.1 - 4.5 6.8 14.9 0.027 14.0 3.7 2.2 2 0 0 2 2 2 0 IncA protein NARP1 PF12569.3 CDI81696.1 - 8.9 4.9 12.9 13 4.4 8.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Ufd2P_core PF10408.4 CDI81697.1 - 3.9e-63 213.6 0.0 1.9e-35 122.2 0.0 3.1 3 0 0 3 3 3 3 Ubiquitin elongating factor core U-box PF04564.10 CDI81697.1 - 3.7e-27 94.0 1.3 8.1e-27 93.0 0.9 1.6 1 0 0 1 1 1 1 U-box domain IncA PF04156.9 CDI81698.1 - 0.0041 16.7 6.7 0.0041 16.7 4.7 2.9 2 1 1 3 3 3 1 IncA protein Glyco_hydro_65m PF03632.10 CDI81698.1 - 0.44 9.1 3.2 0.19 10.3 0.3 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 65 central catalytic domain PIH1 PF08190.7 CDI81701.1 - 9.5e-17 61.4 0.0 1.7e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 zf-Tim10_DDP PF02953.10 CDI81702.1 - 1e-14 53.5 4.2 1.9e-14 52.6 2.9 1.5 1 1 0 1 1 1 1 Tim10/DDP family zinc finger PMEI PF04043.10 CDI81702.1 - 0.085 12.7 0.2 0.088 12.7 0.2 1.1 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor DUF842 PF05811.8 CDI81702.1 - 0.34 10.3 3.3 0.48 9.8 2.2 1.3 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) UPF0020 PF01170.13 CDI81706.1 - 2.6e-06 27.1 0.0 7.2e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Ycf1 PF05758.7 CDI81706.1 - 0.26 8.9 15.7 0.0051 14.6 1.1 2.8 3 0 0 3 3 3 0 Ycf1 SOBP PF15279.1 CDI81706.1 - 0.48 10.7 35.6 1.2 9.4 6.3 3.1 3 0 0 3 3 3 0 Sine oculis-binding protein EPL1 PF10513.4 CDI81706.1 - 0.48 10.6 32.7 0.52 10.5 0.5 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like SAGA-Tad1 PF12767.2 CDI81706.1 - 0.55 9.8 32.0 1.4 8.5 7.7 3.4 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit SPX PF03105.14 CDI81706.1 - 0.75 9.5 20.0 0.21 11.3 3.2 3.1 3 0 0 3 3 3 0 SPX domain UQ_con PF00179.21 CDI81712.1 - 6.5e-39 132.5 0.1 1.1e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDI81712.1 - 0.11 12.4 0.4 0.28 11.0 0.2 2.0 1 1 0 1 1 1 0 RWD domain Peptidase_S49_N PF08496.5 CDI81712.1 - 5 6.8 6.2 7.2 6.3 4.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RRS1 PF04939.7 CDI81714.1 - 1.4e-29 102.6 4.5 1e-28 99.8 0.4 2.2 2 0 0 2 2 2 2 Ribosome biogenesis regulatory protein (RRS1) DHHA1 PF02272.14 CDI81714.1 - 5.4 6.8 13.0 21 4.9 8.8 2.2 1 1 0 1 1 1 0 DHHA1 domain Apt1 PF10351.4 CDI81715.1 - 0.009 14.9 8.4 1.3 7.7 0.0 2.4 2 1 0 2 2 2 2 Golgi-body localisation protein domain CAF-1_p150 PF11600.3 CDI81715.1 - 0.65 9.3 29.9 0.032 13.6 12.7 3.1 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal FLO_LFY PF01698.11 CDI81715.1 - 9 5.0 16.8 2.9 6.6 8.3 2.4 2 0 0 2 2 2 0 Floricaula / Leafy protein GAGA_bind PF06217.7 CDI81717.1 - 0.4 10.5 8.5 0.48 10.3 5.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Activator_LAG-3 PF11498.3 CDI81717.1 - 0.48 9.1 44.4 0.67 8.6 30.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PAT1 PF09770.4 CDI81717.1 - 1.7 6.7 33.6 2 6.5 23.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI81717.1 - 3.4 5.7 37.9 4.3 5.3 26.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Helicase_C PF00271.26 CDI81718.1 - 7.6e-12 44.9 0.0 3.1e-11 42.9 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 CDI81718.1 - 9.9e-12 44.7 0.1 9.9e-12 44.7 0.1 4.7 4 2 0 4 4 4 1 Helicase associated domain (HA2) DEAD PF00270.24 CDI81718.1 - 0.00013 21.4 0.1 0.22 11.0 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase BCS1_N PF08740.6 CDI81719.1 - 4.1e-22 78.6 0.0 4.1e-22 78.6 0.0 2.3 2 0 0 2 2 1 1 BCS1 N terminal AAA PF00004.24 CDI81719.1 - 2.5e-13 50.3 0.0 1.2e-11 44.9 0.0 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 CDI81719.1 - 0.00032 20.3 6.6 0.0055 16.3 3.4 2.6 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDI81719.1 - 0.00076 20.2 0.0 0.0019 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CDI81719.1 - 0.00078 18.8 0.0 0.0017 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI81719.1 - 0.0024 17.8 0.2 0.0024 17.8 0.1 2.5 2 1 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.1 CDI81719.1 - 0.0056 16.5 3.4 0.023 14.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.9 CDI81719.1 - 0.014 15.1 0.8 0.037 13.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CDI81719.1 - 0.023 14.4 0.0 0.066 12.9 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_14 PF13173.1 CDI81719.1 - 0.025 14.4 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 CDI81719.1 - 0.043 13.9 0.8 0.12 12.4 0.0 2.2 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 CDI81719.1 - 0.075 13.2 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Miro PF08477.8 CDI81719.1 - 0.09 13.2 0.3 0.82 10.1 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein KaiC PF06745.8 CDI81719.1 - 0.095 11.8 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.1 CDI81719.1 - 0.13 12.1 0.0 0.13 12.1 0.0 3.1 3 0 0 3 3 2 0 AAA domain Med15 PF09606.5 CDI81719.1 - 0.27 9.3 31.4 0.2 9.8 0.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal ABC_tran PF00005.22 CDI81719.1 - 0.31 11.3 5.3 0.35 11.1 0.0 2.7 3 0 0 3 3 3 0 ABC transporter FimP PF09766.4 CDI81719.1 - 1.9 7.4 19.6 0.076 12.0 8.3 1.9 2 0 0 2 2 2 0 Fms-interacting protein Spt20 PF12090.3 CDI81719.1 - 2.6 7.3 10.0 5.9 6.2 4.0 2.3 2 0 0 2 2 2 0 Spt20 family Suf PF05843.9 CDI81719.1 - 7.9 6.1 11.5 3.6 7.2 4.8 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Pribosyltran_N PF13793.1 CDI81720.1 - 7.2e-47 157.9 0.2 1.3e-45 153.8 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 CDI81720.1 - 1.3e-35 122.8 1.0 2.5e-35 121.8 0.7 1.5 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 CDI81720.1 - 3.2e-10 39.7 0.6 1.1e-09 38.0 0.4 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CDI81720.1 - 0.00045 19.4 0.0 0.00081 18.6 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Poty_coat PF00767.13 CDI81725.1 - 0.032 13.4 0.7 0.091 12.0 0.5 1.7 1 0 0 1 1 1 0 Potyvirus coat protein DXP_synthase_N PF13292.1 CDI81727.1 - 8.5e-53 179.0 0.0 8.5e-53 179.0 0.0 1.9 2 1 0 2 2 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.19 CDI81727.1 - 3e-32 111.5 0.0 3e-32 111.5 0.0 2.7 2 1 0 2 2 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CDI81727.1 - 4.4e-11 42.7 1.1 1.4e-09 37.9 0.0 3.0 2 1 0 2 2 2 1 Transketolase, C-terminal domain Transketolase_N PF00456.16 CDI81727.1 - 1.6e-07 30.5 2.8 0.0076 15.0 1.4 2.7 2 1 0 2 2 2 2 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.15 CDI81727.1 - 0.0013 17.5 0.0 0.0013 17.5 0.0 2.3 2 0 0 2 2 2 1 Dehydrogenase E1 component SR-25 PF10500.4 CDI81727.1 - 0.0022 17.5 8.6 0.0022 17.5 6.0 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Spt20 PF12090.3 CDI81727.1 - 0.005 16.2 7.1 0.014 14.7 0.9 2.4 2 0 0 2 2 2 1 Spt20 family ETRAMP PF09716.5 CDI81727.1 - 0.096 12.6 0.2 0.096 12.6 0.1 2.6 4 0 0 4 4 1 0 Malarial early transcribed membrane protein (ETRAMP) Neur_chan_memb PF02932.11 CDI81727.1 - 0.35 10.7 1.6 0.63 9.8 1.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pap_E4 PF02711.9 CDI81727.1 - 0.64 10.8 7.8 11 6.8 0.2 2.8 2 0 0 2 2 2 0 E4 protein RAB3GAP2_N PF14655.1 CDI81727.1 - 1.1 8.1 13.4 0.63 8.9 2.4 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4207 PF13904.1 CDI81727.1 - 2.1 7.6 26.5 9.5 5.5 18.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4207) Rpp20 PF12328.3 CDI81727.1 - 3.4 7.3 10.4 17 5.0 0.1 2.3 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Activator_LAG-3 PF11498.3 CDI81727.1 - 6.5 5.3 33.7 1.9 7.1 12.2 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Amidohydro_2 PF04909.9 CDI81727.1 - 9.3 5.7 17.5 0.13 11.8 6.0 2.0 2 0 0 2 2 2 0 Amidohydrolase Trypan_PARP PF05887.6 CDI81728.1 - 0.0033 17.2 4.7 0.0033 17.2 3.2 4.6 2 1 2 4 4 4 1 Procyclic acidic repetitive protein (PARP) LMBR1 PF04791.11 CDI81728.1 - 0.0054 15.3 8.2 0.0084 14.7 5.8 1.4 1 1 0 1 1 1 1 LMBR1-like membrane protein Archease PF01951.11 CDI81729.1 - 3.9e-31 107.8 0.1 6e-31 107.2 0.1 1.3 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) DUF4571 PF15137.1 CDI81729.1 - 0.023 14.1 3.5 0.78 9.1 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4571) RNA_pol_Rbc25 PF08292.7 CDI81729.1 - 0.11 12.6 7.4 0.34 11.0 0.6 2.4 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 DUF2489 PF10675.4 CDI81729.1 - 1.2 8.8 24.1 3.3 7.4 2.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Hid1 PF12722.2 CDI81729.1 - 1.2 6.6 17.9 0.3 8.7 6.3 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Ribosomal_S26e PF01283.14 CDI81729.1 - 1.5 9.0 6.3 0.14 12.3 0.3 2.0 2 0 0 2 2 2 0 Ribosomal protein S26e BBS2_C PF14782.1 CDI81729.1 - 1.5 7.2 17.4 2 6.9 11.6 1.4 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Chorein_N PF12624.2 CDI81729.1 - 2.6 7.5 6.1 3.6 7.1 0.8 2.3 2 0 0 2 2 2 0 N-terminal region of Chorein, a TM vesicle-mediated sorter XRN_N PF03159.13 CDI81729.1 - 2.7 7.3 16.2 6.8 5.9 6.2 2.5 2 1 1 3 3 3 0 XRN 5'-3' exonuclease N-terminus TFIIA PF03153.8 CDI81729.1 - 2.7 7.7 30.5 2.1 8.1 16.0 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit E7 PF00527.13 CDI81729.1 - 6.1 7.0 15.5 3.4 7.8 1.0 2.4 2 0 0 2 2 2 0 E7 protein, Early protein DUF4647 PF15504.1 CDI81729.1 - 7.6 5.2 22.0 12 4.6 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DEAD PF00270.24 CDI81730.1 - 3.6e-35 120.9 0.0 6.9e-35 120.0 0.0 1.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase SPRY PF00622.23 CDI81730.1 - 0.0098 15.9 0.0 0.025 14.6 0.0 1.6 1 1 0 1 1 1 1 SPRY domain DUF3613 PF12266.3 CDI81730.1 - 0.016 14.6 0.0 0.067 12.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3613) ResIII PF04851.10 CDI81730.1 - 0.11 12.3 0.0 25 4.6 0.0 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Ribosomal_L28e PF01778.12 CDI81732.1 - 1.4e-20 73.8 1.5 1.6e-20 73.6 1.1 1.0 1 0 0 1 1 1 1 Ribosomal L28e protein family PfkB PF00294.19 CDI81734.1 - 2.7e-29 102.2 0.2 8e-29 100.7 0.1 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Adenyl_cycl_N PF12633.2 CDI81734.1 - 0.08 12.4 0.3 0.24 10.9 0.1 1.7 2 0 0 2 2 2 0 Adenylate cyclase NT domain PsbL PF02419.12 CDI81736.1 - 2.3 7.7 3.9 4.4 6.8 2.7 1.4 1 0 0 1 1 1 0 PsbL protein DUF4570 PF15134.1 CDI81739.1 - 2.9 7.7 13.2 0.33 10.7 4.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4570) Spore_coat_CotO PF14153.1 CDI81740.1 - 0.00016 21.1 13.2 0.00016 21.1 9.1 2.2 2 0 0 2 2 2 1 Spore coat protein CotO TT_ORF1 PF02956.9 CDI81740.1 - 0.00093 17.7 3.2 0.0015 17.0 2.2 1.3 1 0 0 1 1 1 1 TT viral orf 1 SPX PF03105.14 CDI81740.1 - 0.00098 18.9 7.9 0.00098 18.9 5.5 1.9 2 1 0 2 2 2 1 SPX domain Exonuc_VII_L PF02601.10 CDI81740.1 - 0.0013 18.0 14.3 0.0052 16.0 4.6 2.2 2 0 0 2 2 2 2 Exonuclease VII, large subunit LMBR1 PF04791.11 CDI81740.1 - 0.08 11.5 0.4 0.11 11.0 0.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein GAGA_bind PF06217.7 CDI81740.1 - 0.35 10.7 18.2 0.45 10.4 9.0 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Neur_chan_memb PF02932.11 CDI81740.1 - 0.94 9.3 14.2 0.29 10.9 7.0 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region MRP-S31 PF15433.1 CDI81740.1 - 2.1 7.6 30.9 0.23 10.8 15.7 2.3 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 PAT1 PF09770.4 CDI81740.1 - 3.2 5.8 59.9 1.5 6.9 29.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DDHD PF02862.12 CDI81740.1 - 5.7 6.6 22.8 3.6 7.3 11.5 2.3 2 0 0 2 2 2 0 DDHD domain BAF1_ABF1 PF04684.8 CDI81741.1 - 0.0014 17.6 23.4 0.0014 17.6 16.2 5.5 4 1 1 5 5 5 1 BAF1 / ABF1 chromatin reorganising factor SR-25 PF10500.4 CDI81741.1 - 0.011 15.1 3.6 0.011 15.1 2.5 3.9 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein zf-CCCH PF00642.19 CDI81741.1 - 0.056 13.1 1.4 0.13 12.0 0.9 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) X PF00739.14 CDI81741.1 - 0.65 9.9 9.0 0.35 10.7 1.5 2.7 2 0 0 2 2 2 0 Trans-activation protein X Glt_symporter PF03616.9 CDI81743.1 - 0.00091 17.8 2.0 0.00091 17.8 1.4 2.9 3 1 1 4 4 4 1 Sodium/glutamate symporter Med15 PF09606.5 CDI81743.1 - 0.0026 16.0 14.7 0.0026 16.0 10.2 4.2 3 1 1 4 4 4 3 ARC105 or Med15 subunit of Mediator complex non-fungal Pentapeptide_2 PF01469.13 CDI81743.1 - 0.089 12.4 6.3 0.15 11.6 4.3 1.2 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) DUF3843 PF12954.2 CDI81743.1 - 7.7 5.4 20.4 0.73 8.8 9.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3843) Rio2_N PF09202.6 CDI81745.1 - 8.9e-33 112.2 0.8 1.4e-32 111.5 0.6 1.3 1 0 0 1 1 1 1 Rio2, N-terminal RIO1 PF01163.17 CDI81745.1 - 3.4e-19 68.9 0.0 5.5e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 CDI81745.1 - 0.00011 21.9 0.2 0.00021 21.1 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CDI81745.1 - 0.00039 19.5 0.0 0.00079 18.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_45 PF14947.1 CDI81745.1 - 0.025 14.3 0.0 0.24 11.2 0.1 2.4 2 1 0 2 2 2 0 Winged helix-turn-helix YjcQ PF09639.5 CDI81745.1 - 0.046 13.8 0.0 0.094 12.8 0.0 1.6 1 0 0 1 1 1 0 YjcQ protein TrmB PF01978.14 CDI81745.1 - 0.096 12.3 0.3 2.3 8.0 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_9 PF08221.6 CDI81745.1 - 0.11 12.3 0.2 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Na_H_Exchanger PF00999.16 CDI81753.1 - 1.8e-15 56.3 4.3 1.8e-15 56.3 3.0 2.0 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family Apt1 PF10351.4 CDI81753.1 - 0.074 11.8 3.8 0.13 11.1 2.6 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1049 PF06305.6 CDI81753.1 - 0.82 9.1 4.3 0.58 9.6 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Beta-Casp PF10996.3 CDI81773.1 - 9.1e-24 83.7 0.0 2.3e-23 82.5 0.0 1.7 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.7 CDI81773.1 - 0.022 14.5 0.1 0.051 13.3 0.0 1.7 2 0 0 2 2 2 0 RNA-metabolising metallo-beta-lactamase F-box-like PF12937.2 CDI81774.1 - 2.7e-06 27.0 0.0 2.7e-06 27.0 0.0 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 CDI81774.1 - 0.11 12.2 0.0 0.11 12.2 0.0 2.8 3 0 0 3 3 3 0 F-box domain Serpin PF00079.15 CDI81782.1 - 6.4e-23 81.4 0.0 7.5e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cpn60_TCP1 PF00118.19 CDI81785.1 - 4e-99 332.4 11.8 2.3e-84 283.7 5.6 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Fis1_TPR_C PF14853.1 CDI81787.1 - 4.5e-12 45.6 0.1 1.1e-11 44.4 0.1 1.7 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 CDI81787.1 - 1.5e-05 24.1 0.0 3.2e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_11 PF13414.1 CDI81787.1 - 0.0024 17.4 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 CDI81787.1 - 0.017 15.0 0.3 0.054 13.4 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDI81787.1 - 0.059 13.3 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat UBA PF00627.26 CDI81787.1 - 0.07 13.0 0.1 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 UBA/TS-N domain TPR_16 PF13432.1 CDI81787.1 - 0.1 13.2 0.3 0.37 11.5 0.2 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 CDI81787.1 - 0.14 11.8 0.1 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDI81787.1 - 0.28 11.7 2.2 0.41 11.2 0.2 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3223 PF11523.3 CDI81788.1 - 0.071 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3223) DUF1375 PF07119.7 CDI81788.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1375) DNA_pol_E_B PF04042.11 CDI81792.1 - 2e-21 76.2 5.5 3.2e-20 72.2 2.5 3.1 2 1 1 3 3 3 1 DNA polymerase alpha/epsilon subunit B DUF3847 PF12958.2 CDI81792.1 - 0.1 12.3 0.2 0.1 12.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Ribosomal_60s PF00428.14 CDI81792.1 - 0.53 10.7 11.9 2.1 8.8 1.5 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein C2 PF00168.25 CDI81794.1 - 3e-26 91.0 0.1 2.8e-07 30.2 0.0 7.1 7 0 0 7 7 7 5 C2 domain FerI PF08151.7 CDI81794.1 - 0.046 13.7 0.0 0.72 9.9 0.0 2.4 2 0 0 2 2 2 0 FerI (NUC094) domain zf-RING_2 PF13639.1 CDI81795.1 - 2.1e-13 49.8 9.0 3.5e-13 49.1 6.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDI81795.1 - 7.6e-08 31.8 8.4 1.2e-07 31.2 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDI81795.1 - 8.6e-08 32.1 3.1 1.6e-07 31.2 2.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 CDI81795.1 - 1.3e-05 24.7 4.5 2.1e-05 24.1 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDI81795.1 - 2.7e-05 23.9 1.7 5.4e-05 22.9 1.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 CDI81795.1 - 2.7e-05 24.0 9.6 4.4e-05 23.4 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI81795.1 - 5.6e-05 22.7 7.2 9.1e-05 22.1 5.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.3 CDI81795.1 - 0.00043 19.7 3.2 0.00091 18.6 2.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 CDI81795.1 - 0.0066 16.1 4.9 0.013 15.2 3.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CDI81795.1 - 0.012 15.5 6.8 0.022 14.6 4.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 CDI81795.1 - 0.029 14.4 9.1 0.055 13.5 6.3 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 CDI81795.1 - 0.56 10.1 7.7 2.2 8.3 5.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain AAA_13 PF13166.1 CDI81797.1 - 9.3 4.5 25.2 17 3.7 17.5 1.4 1 0 0 1 1 1 0 AAA domain Phosphodiest PF01663.17 CDI81800.1 - 0.00016 21.1 0.0 0.00026 20.4 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Tub_2 PF04525.7 CDI81801.1 - 0.039 13.3 0.1 0.082 12.2 0.1 1.4 1 0 0 1 1 1 0 Tubby C 2 PVL_ORF50 PF07768.6 CDI81801.1 - 0.24 11.3 3.2 0.63 10.0 2.2 1.6 1 0 0 1 1 1 0 PVL ORF-50-like family cNMP_binding PF00027.24 CDI81802.1 - 1.2e-83 274.9 2.7 2.9e-19 68.6 0.0 6.7 5 1 1 6 6 6 6 Cyclic nucleotide-binding domain EF-hand_1 PF00036.27 CDI81802.1 - 0.00015 20.7 0.6 0.11 11.9 0.1 3.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 CDI81802.1 - 0.0027 17.7 0.4 2.5 8.2 0.0 4.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 CDI81802.1 - 0.0034 16.9 0.4 4.4 6.9 0.2 4.2 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.1 CDI81802.1 - 0.01 15.6 0.7 4.2 7.5 0.1 3.7 3 0 0 3 3 3 0 EF-hand domain RRM_6 PF14259.1 CDI81803.1 - 3.2e-13 49.4 0.1 9.5e-05 22.3 0.0 3.9 5 0 0 5 5 5 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI81803.1 - 5.7e-13 48.3 0.0 0.00025 20.6 0.0 5.0 5 0 0 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI81803.1 - 3.1e-08 33.3 0.0 8.2e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP21_like_P PF12230.3 CDI81804.1 - 2.2e-46 158.2 9.6 2.2e-46 158.2 6.6 2.4 2 1 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 CDI81804.1 - 4.1e-34 116.0 1.4 2.5e-16 59.0 0.0 2.9 3 0 0 3 3 3 2 Surp module DUF1682 PF07946.9 CDI81804.1 - 0.00055 18.8 3.0 0.00055 18.8 2.1 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1682) Peptidase_S9 PF00326.16 CDI81805.1 - 3.6e-33 114.5 0.0 3.6e-33 114.5 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CDI81805.1 - 1.9e-11 43.8 0.1 1.7e-10 40.8 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 CDI81805.1 - 1.7e-05 24.1 0.1 5.3e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_1 PF00561.15 CDI81805.1 - 0.00038 20.0 0.1 0.0018 17.8 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 CDI81805.1 - 0.0073 15.9 0.1 0.032 13.8 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 CDI81805.1 - 0.014 15.2 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase COesterase PF00135.23 CDI81805.1 - 0.017 13.8 0.1 0.017 13.8 0.1 1.7 2 0 0 2 2 2 0 Carboxylesterase family BBS2_C PF14782.1 CDI81805.1 - 1.2 7.6 9.9 1.8 7.0 6.9 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Spore_coat_CotO PF14153.1 CDI81805.1 - 3.9 6.8 18.7 7.2 6.0 12.9 1.3 1 0 0 1 1 1 0 Spore coat protein CotO PapD-like PF14874.1 CDI81806.1 - 3.4e-05 23.7 1.0 0.31 11.0 0.0 3.8 3 0 0 3 3 3 3 Flagellar-associated PapD-like TPR_11 PF13414.1 CDI81808.1 - 3.8e-16 58.4 8.4 9.2e-14 50.8 0.8 2.9 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.1 CDI81808.1 - 2e-12 47.4 13.7 1.6e-07 31.8 2.9 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDI81808.1 - 3.1e-11 42.3 4.0 2.1e-08 33.3 0.4 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI81808.1 - 4.7e-08 32.3 16.8 5.7e-07 28.9 0.4 4.3 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 CDI81808.1 - 4.2e-05 23.3 2.0 0.00018 21.2 0.4 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI81808.1 - 5.3e-05 23.0 1.2 0.0049 16.9 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDI81808.1 - 0.00025 21.3 1.9 0.00072 19.8 1.3 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI81808.1 - 0.00051 20.4 1.0 0.00051 20.4 0.7 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDI81808.1 - 0.00097 18.7 3.9 0.011 15.4 0.1 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDI81808.1 - 0.0069 16.3 1.4 0.0069 16.3 1.0 3.1 2 1 0 3 3 3 1 Tetratricopeptide repeat PAT1 PF09770.4 CDI81808.1 - 0.017 13.4 0.1 0.025 12.8 0.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Apc3 PF12895.2 CDI81808.1 - 0.1 12.7 1.0 0.24 11.5 0.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF1764 PF08576.5 CDI81809.1 - 0.0011 19.7 1.1 0.0015 19.2 0.8 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) SelP_N PF04592.9 CDI81809.1 - 0.022 14.1 7.7 0.029 13.7 5.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MAS20 PF02064.10 CDI81809.1 - 0.037 13.9 7.3 0.053 13.4 5.1 1.4 1 1 0 1 1 1 0 MAS20 protein import receptor DUF2217 PF10265.4 CDI81809.1 - 0.2 10.3 3.2 0.24 10.1 2.2 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF3464 PF11947.3 CDI81809.1 - 0.4 10.1 4.8 0.61 9.5 3.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3464) Hid1 PF12722.2 CDI81809.1 - 0.5 7.9 2.7 0.52 7.9 1.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.11 CDI81809.1 - 0.88 9.4 3.0 1 9.2 2.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Herpes_UL87 PF03043.9 CDI81809.1 - 1.3 7.2 5.2 1.6 7.0 3.6 1.0 1 0 0 1 1 1 0 Herpesvirus UL87 family EIF4E-T PF10477.4 CDI81809.1 - 1.7 7.3 8.6 1.8 7.2 6.0 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Claudin_2 PF13903.1 CDI81809.1 - 2.9 7.5 19.5 4.1 7.0 5.7 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF1980 PF09323.5 CDI81809.1 - 3.7 7.2 5.9 2.1 8.0 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) DUF2892 PF11127.3 CDI81809.1 - 4.1 7.3 0.0 4.1 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) BBS2_N PF14781.1 CDI81809.1 - 5 6.7 6.2 14 5.2 0.9 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal NADH-u_ox-rdase PF10785.4 CDI81809.1 - 5 7.4 6.9 43 4.4 0.0 2.4 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Ctr PF04145.10 CDI81809.1 - 7.4 6.6 8.4 24 4.9 5.9 1.9 1 1 0 1 1 1 0 Ctr copper transporter family DUF4395 PF14340.1 CDI81809.1 - 7.4 6.6 17.3 4.8 7.2 5.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4395) DnaJ PF00226.26 CDI81810.1 - 1.7e-16 59.6 0.4 5.7e-16 58.0 0.3 2.0 1 0 0 1 1 1 1 DnaJ domain Med15 PF09606.5 CDI81811.1 - 0.0002 19.7 6.4 0.0002 19.7 4.4 4.1 3 1 2 5 5 5 2 ARC105 or Med15 subunit of Mediator complex non-fungal Cytochrom_B_N_2 PF13631.1 CDI81811.1 - 0.1 12.4 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Neur_chan_memb PF02932.11 CDI81811.1 - 1.9 8.3 5.0 0.99 9.2 0.1 2.8 2 2 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CAF-1_p150 PF11600.3 CDI81812.1 - 3.3 7.0 29.3 3.8 6.8 20.3 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SR-25 PF10500.4 CDI81812.1 - 5.1 6.5 30.5 11 5.3 21.2 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SprA-related PF12118.3 CDI81812.1 - 5.6 6.1 48.9 6.6 5.9 33.9 1.0 1 0 0 1 1 1 0 SprA-related family SelP_N PF04592.9 CDI81812.1 - 8 5.7 31.5 12 5.1 21.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FimP PF09766.4 CDI81814.1 - 0.0035 16.4 4.9 0.0035 16.4 3.4 2.9 3 0 0 3 3 3 1 Fms-interacting protein Paramyxo_ncap PF00973.14 CDI81814.1 - 0.91 8.1 8.6 2.1 6.9 5.9 1.5 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4366 PF14283.1 CDI81814.1 - 5.3 6.3 15.4 3.9 6.8 0.8 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) Raftlin PF15250.1 CDI81814.1 - 8.3 4.8 14.0 0.14 10.6 3.2 2.4 3 0 0 3 3 3 0 Raftlin TPR_1 PF00515.23 CDI81815.1 - 0.011 15.3 1.3 0.26 10.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat IncA PF04156.9 CDI81815.1 - 0.011 15.3 8.5 0.011 15.3 5.9 4.9 5 0 0 5 5 5 0 IncA protein IQ PF00612.22 CDI81816.1 - 6.4e-09 34.6 29.5 0.0017 17.8 0.4 5.1 5 0 0 5 5 5 4 IQ calmodulin-binding motif Tubulin PF00091.20 CDI81818.1 - 5.7e-68 228.9 0.0 7.7e-68 228.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CDI81818.1 - 1.8e-51 173.4 0.3 7.6e-51 171.4 0.1 1.9 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 CDI81818.1 - 0.025 14.0 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 0 Tubulin domain Ribosomal_L18e PF00828.14 CDI81819.1 - 3.2e-06 27.5 2.0 3.8e-05 24.0 0.3 2.9 2 1 0 2 2 2 1 Ribosomal protein L18e/L15 DUF1664 PF07889.7 CDI81819.1 - 0.006 16.3 0.2 0.006 16.3 0.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Fmp27_WPPW PF10359.4 CDI81819.1 - 0.044 12.1 2.6 0.058 11.8 1.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Utp14 PF04615.8 CDI81820.1 - 4.2 5.4 57.6 6.6 4.7 39.9 1.2 1 0 0 1 1 1 0 Utp14 protein CENP-N PF05238.8 CDI81821.1 - 0.054 12.5 1.1 0.6 9.0 0.0 2.1 1 1 1 2 2 2 0 Kinetochore protein CHL4 like Col_cuticle_N PF01484.12 CDI81821.1 - 2.7 7.7 5.1 5.4 6.7 3.5 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Activator_LAG-3 PF11498.3 CDI81823.1 - 0.0011 17.8 23.8 0.0011 17.8 16.5 3.3 3 0 0 3 3 3 2 Transcriptional activator LAG-3 CDK5_activator PF03261.10 CDI81823.1 - 3.8 6.7 27.7 1.6 7.9 3.8 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein OmpH PF03938.9 CDI81823.1 - 6.6 6.6 33.5 5 7.0 0.9 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) eIF3_subunit PF08597.5 CDI81827.1 - 5.5e-22 78.5 15.1 6.3e-22 78.3 10.4 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit NinG PF05766.7 CDI81827.1 - 7 6.3 9.3 1.4 8.5 2.2 2.1 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein Macoilin PF09726.4 CDI81830.1 - 0.00021 19.7 2.6 0.00026 19.4 1.8 1.1 1 0 0 1 1 1 1 Transmembrane protein CDC45 PF02724.9 CDI81830.1 - 0.11 10.5 16.8 0.16 9.9 11.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 CDI81830.1 - 0.39 10.0 19.2 0.73 9.1 13.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF605 PF04652.11 CDI81830.1 - 0.73 9.1 26.1 0.21 10.9 8.8 2.3 2 0 0 2 2 2 0 Vta1 like SAPS PF04499.10 CDI81830.1 - 0.84 8.1 10.8 1.2 7.6 7.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ycf1 PF05758.7 CDI81830.1 - 2.3 5.8 14.1 3 5.4 9.8 1.0 1 0 0 1 1 1 0 Ycf1 Spore_YhcN_YlaJ PF09580.5 CDI81830.1 - 4.2 7.4 17.6 10 6.2 12.2 1.7 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Chromo PF00385.19 CDI81833.1 - 3.9e-15 55.2 0.0 6e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC_2 PF13696.1 CDI81833.1 - 0.015 14.7 1.1 0.015 14.7 0.7 1.8 2 0 0 2 2 2 0 Zinc knuckle FAT PF02259.18 CDI81834.1 - 8.9e-12 44.6 20.5 5.1e-11 42.1 14.2 2.3 1 1 0 1 1 1 1 FAT domain DUF1183 PF06682.7 CDI81834.1 - 0.0018 17.9 2.3 0.0026 17.4 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Cwf_Cwc_15 PF04889.7 CDI81834.1 - 0.0035 17.0 3.3 0.005 16.5 2.3 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF755 PF05501.6 CDI81834.1 - 0.035 14.1 21.1 0.096 12.7 14.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Ndc1_Nup PF09531.5 CDI81834.1 - 0.041 12.3 6.9 0.065 11.6 4.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup 60KD_IMP PF02096.15 CDI81834.1 - 0.088 12.4 3.0 0.065 12.8 0.8 1.6 2 0 0 2 2 2 0 60Kd inner membrane protein Mem_trans PF03547.13 CDI81834.1 - 0.11 10.7 0.9 0.16 10.2 0.7 1.1 1 0 0 1 1 1 0 Membrane transport protein Neur_chan_memb PF02932.11 CDI81834.1 - 0.7 9.7 3.7 1.3 8.8 2.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.1 CDI81834.1 - 0.8 9.4 6.2 1.3 8.7 4.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF2217 PF10265.4 CDI81834.1 - 0.9 8.2 7.7 1.7 7.3 5.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) RAP1 PF07218.6 CDI81834.1 - 1.9 6.4 5.1 2.6 6.0 3.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apc15p PF05841.6 CDI81834.1 - 2.6 8.8 16.4 5.1 7.8 11.4 1.4 1 0 0 1 1 1 0 Apc15p protein Serendipity_A PF05482.7 CDI81835.1 - 0.15 10.5 0.0 0.21 9.9 0.0 1.1 1 0 0 1 1 1 0 Serendipity locus alpha protein (SRY-A) Aminotran_1_2 PF00155.16 CDI81837.1 - 1.5e-22 80.0 0.0 3.2e-14 52.6 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class I and II Kdo PF06293.9 CDI81838.1 - 0.00013 21.1 0.2 0.23 10.4 0.0 2.9 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 CDI81838.1 - 0.001 18.2 0.0 0.54 9.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 CDI81838.1 - 0.099 11.9 0.1 6.1 6.1 0.0 2.7 3 0 0 3 3 3 0 RIO1 family APH PF01636.18 CDI81838.1 - 0.34 10.6 2.4 9.7 5.8 0.0 3.2 3 1 0 3 3 3 0 Phosphotransferase enzyme family TauE PF01925.14 CDI81841.1 - 1.7e-08 34.2 3.7 1.7e-08 34.2 2.6 3.2 3 0 0 3 3 3 2 Sulfite exporter TauE/SafE Ycf1 PF05758.7 CDI81844.1 - 0.00055 17.8 4.5 0.00055 17.8 3.1 2.0 2 0 0 2 2 2 2 Ycf1 BAF1_ABF1 PF04684.8 CDI81844.1 - 0.0011 17.9 21.0 0.0011 17.9 14.5 7.4 6 2 2 8 8 8 1 BAF1 / ABF1 chromatin reorganising factor Med3 PF11593.3 CDI81844.1 - 0.031 13.5 0.2 0.031 13.5 0.2 7.9 5 3 2 7 7 7 0 Mediator complex subunit 3 fungal Utp14 PF04615.8 CDI81844.1 - 1.2 7.1 35.2 1.9 6.5 24.4 1.2 1 0 0 1 1 1 0 Utp14 protein DUF4179 PF13786.1 CDI81844.1 - 3.5 7.9 0.0 3.5 7.9 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4179) DUF4647 PF15504.1 CDI81844.1 - 5.1 5.8 36.3 1.8 7.3 14.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Anoctamin PF04547.7 CDI81844.1 - 7.5 5.0 13.4 0.21 10.1 0.8 2.1 2 0 0 2 2 2 0 Calcium-activated chloride channel AUX_IAA PF02309.11 CDI81849.1 - 5 6.8 8.2 6.8 6.3 2.3 2.3 2 0 0 2 2 2 0 AUX/IAA family DDHD PF02862.12 CDI81849.1 - 6.9 6.3 9.8 2.4 7.9 2.6 2.3 2 0 0 2 2 2 0 DDHD domain XRN_N PF03159.13 CDI81850.1 - 2.8e-76 256.0 0.3 3.7e-76 255.6 0.2 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus DUF3729 PF12526.3 CDI81852.1 - 0.026 15.8 10.6 0.026 15.8 7.4 10.7 3 2 7 11 11 11 0 Protein of unknown function (DUF3729) CRF1 PF10380.4 CDI81852.1 - 6.1 7.2 0.0 6.1 7.2 0.0 12.6 5 3 2 7 7 7 0 Transcription factor CRF1 Ank PF00023.25 CDI81853.1 - 3.5e-27 92.8 9.7 2.1e-09 36.7 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 CDI81853.1 - 7.5e-27 93.5 2.8 2.7e-14 53.2 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI81853.1 - 5.5e-21 74.5 3.6 2.9e-09 37.1 0.0 3.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI81853.1 - 4.3e-18 63.5 2.2 9.3e-06 25.4 0.1 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 CDI81853.1 - 5e-18 64.7 9.7 2.1e-05 24.5 0.0 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Macoilin PF09726.4 CDI81853.1 - 3.1 5.9 7.6 5 5.2 5.2 1.3 1 0 0 1 1 1 0 Transmembrane protein Alkyl_sulf_C PF14864.1 CDI81854.1 - 1.7e-06 28.0 0.1 0.0048 16.8 0.0 2.9 2 0 0 2 2 2 2 Alkyl sulfatase C-terminal Lactamase_B PF00753.22 CDI81854.1 - 0.0015 18.2 0.0 0.043 13.4 0.0 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily CDC45 PF02724.9 CDI81854.1 - 0.0021 16.1 13.5 0.0021 16.1 9.4 3.0 4 0 0 4 4 4 2 CDC45-like protein Neur_chan_memb PF02932.11 CDI81854.1 - 0.0047 16.8 10.4 0.0047 16.8 7.2 3.6 4 0 0 4 4 4 2 Neurotransmitter-gated ion-channel transmembrane region Lactamase_B_2 PF12706.2 CDI81854.1 - 0.012 15.1 0.3 0.03 13.8 0.2 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Med15 PF09606.5 CDI81854.1 - 6.3 4.8 166.6 0.015 13.5 2.5 4.1 4 0 0 4 4 4 0 ARC105 or Med15 subunit of Mediator complex non-fungal Daxx PF03344.10 CDI81854.1 - 6.9 5.0 54.9 0.36 9.2 13.6 2.6 3 0 0 3 3 3 0 Daxx Family CAF1C_H4-bd PF12265.3 CDI81855.1 - 1e-15 57.3 0.0 1.9e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 CDI81855.1 - 1.9e-10 40.1 6.7 0.00095 18.9 0.0 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF3138 PF11336.3 CDI81855.1 - 0.47 8.5 3.0 0.7 7.9 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RAP1 PF07218.6 CDI81855.1 - 5 5.0 11.0 9.9 4.1 7.6 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) KBP_C PF12309.3 CDI81856.1 - 1.8e-20 73.2 0.2 1.8e-20 73.2 0.1 6.5 5 1 1 6 6 6 1 KIF-1 binding protein C terminal SpoIIIAH PF12685.2 CDI81856.1 - 0.064 12.7 0.1 0.064 12.7 0.1 8.4 4 3 2 6 6 6 0 SpoIIIAH-like protein DUF4603 PF15376.1 CDI81857.1 - 0.54 7.3 22.1 0.81 6.8 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) SOBP PF15279.1 CDI81857.1 - 0.95 9.7 28.4 0.15 12.3 16.0 1.9 2 0 0 2 2 2 0 Sine oculis-binding protein DUF87 PF01935.12 CDI81857.1 - 1.5 8.5 3.8 2.4 7.8 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 SR-25 PF10500.4 CDI81857.1 - 1.8 7.9 48.4 0.27 10.6 16.1 3.2 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 CDI81858.1 - 0.00018 19.9 17.2 0.00018 19.9 11.9 3.9 4 0 0 4 4 4 2 Transmembrane protein TPR_2 PF07719.12 CDI81858.1 - 3.6 7.7 21.5 2.5 8.2 0.1 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3334 PF11813.3 CDI81859.1 - 0.032 13.7 0.1 0.048 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3334) FluMu_gp41 PF10109.4 CDI81859.1 - 0.063 13.2 0.1 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Mu-like prophage FluMu protein gp41 Myb_DNA-bind_6 PF13921.1 CDI81859.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Pkinase PF00069.20 CDI81862.1 - 8.4e-54 182.4 1.8 2.7e-53 180.7 0.0 2.5 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI81862.1 - 9.1e-22 77.3 0.0 4.7e-21 75.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pre-SET PF05033.11 CDI81864.1 - 6.2e-05 23.2 0.6 0.00013 22.2 0.0 1.7 2 0 0 2 2 2 1 Pre-SET motif SAD_SRA PF02182.12 CDI81865.1 - 1.3e-07 31.0 0.0 1.3e-07 31.0 0.0 3.0 3 0 0 3 3 3 1 SAD/SRA domain EF-hand_6 PF13405.1 CDI81867.1 - 0.026 14.3 0.1 0.15 12.0 0.0 2.3 2 2 0 2 2 2 0 EF-hand domain DUF3381 PF11861.3 CDI81869.1 - 1.6e-23 82.9 14.3 1.6e-23 82.9 9.9 5.9 2 1 3 5 5 5 1 Domain of unknown function (DUF3381) FtsJ PF01728.14 CDI81869.1 - 1.3e-08 35.0 0.0 3.3e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF957 PF06117.6 CDI81869.1 - 0.0082 15.6 0.2 0.053 13.0 0.1 2.4 1 0 0 1 1 1 1 Enterobacterial protein of unknown function (DUF957) ASFV_J13L PF05568.6 CDI81869.1 - 1 8.8 7.3 2.4 7.6 0.8 2.5 2 0 0 2 2 2 0 African swine fever virus J13L protein DUF3446 PF11928.3 CDI81869.1 - 2.1 8.5 11.7 0.15 12.2 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) CRT10 PF08728.5 CDI81871.1 - 0.4 8.6 3.3 0.48 8.3 2.3 1.1 1 0 0 1 1 1 0 CRT10 Form_Nir_trans PF01226.12 CDI81876.1 - 6.2e-07 28.5 1.7 1.1e-06 27.7 1.2 1.4 1 1 0 1 1 1 1 Formate/nitrite transporter HEAT PF02985.17 CDI81877.1 - 3.3e-06 26.7 9.5 0.0018 18.2 0.3 3.7 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.1 CDI81877.1 - 0.00011 22.5 6.2 0.76 10.3 0.1 3.9 2 2 1 3 3 3 3 HEAT-like repeat HEAT_2 PF13646.1 CDI81877.1 - 0.00017 21.8 1.1 0.016 15.5 0.2 3.2 1 1 2 3 3 3 2 HEAT repeats Arm PF00514.18 CDI81877.1 - 0.07 12.9 0.0 0.07 12.9 0.0 2.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat RPA_C PF08784.6 CDI81879.1 - 2.2 8.7 5.0 16 5.9 0.2 3.5 3 1 0 3 3 3 0 Replication protein A C terminal CENP-F_leu_zip PF10473.4 CDI81880.1 - 0.007 16.2 4.5 0.007 16.2 3.1 2.7 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 CDI81880.1 - 6.2 7.2 10.1 1.3 9.3 2.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF972) PAT1 PF09770.4 CDI81880.1 - 7.5 4.6 36.0 0.4 8.8 8.8 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PARP PF00644.15 CDI81883.1 - 7.7e-56 188.7 0.0 1.4e-55 187.9 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 CDI81883.1 - 7.7e-25 87.1 3.4 1.4e-24 86.2 1.1 2.2 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 CDI81883.1 - 5.9e-09 35.7 0.3 2.1e-08 34.0 0.2 1.9 1 0 0 1 1 1 1 WGR domain BRCT PF00533.21 CDI81883.1 - 2.9e-08 33.7 0.0 6.8e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-PARP PF00645.13 CDI81883.1 - 1.6e-06 28.2 0.3 6.5e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PTCB-BRCT PF12738.2 CDI81883.1 - 0.00019 21.2 0.0 0.00044 20.0 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain PADR1 PF08063.7 CDI81883.1 - 0.00043 19.6 0.0 0.0011 18.2 0.0 1.8 1 0 0 1 1 1 1 PADR1 (NUC008) domain Ribosomal_L27e PF01777.13 CDI81884.1 - 2e-23 82.3 3.3 2.5e-23 81.9 2.3 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 CDI81884.1 - 0.00024 20.6 0.4 0.00047 19.7 0.3 1.5 1 0 0 1 1 1 1 KOW motif DUF3673 PF12425.3 CDI81885.1 - 0.073 12.9 0.4 0.16 11.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) Nitrate_red_gam PF02665.9 CDI81887.1 - 0.42 9.9 0.1 0.66 9.2 0.1 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Claudin_2 PF13903.1 CDI81888.1 - 5.4 6.6 13.1 8.2 6.0 8.3 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Glyco_transf_9 PF01075.12 CDI81889.1 - 0.038 13.1 3.7 0.12 11.5 0.1 2.7 3 0 0 3 3 3 0 Glycosyltransferase family 9 (heptosyltransferase) DUF605 PF04652.11 CDI81890.1 - 3.1 7.0 46.8 1.3 8.3 4.0 3.1 3 0 0 3 3 3 0 Vta1 like Adaptin_binding PF10199.4 CDI81890.1 - 3.9 7.7 38.2 0.54 10.5 3.3 3.4 3 0 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 Suf PF05843.9 CDI81890.1 - 5.5 6.6 45.6 0.11 12.2 1.1 3.3 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) SF-assemblin PF06705.6 CDI81892.1 - 0.018 14.2 9.0 0.036 13.2 5.9 1.7 1 1 0 1 1 1 0 SF-assemblin/beta giardin DUF4140 PF13600.1 CDI81892.1 - 0.036 14.5 4.1 0.036 14.5 2.9 2.9 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) FlgN PF05130.7 CDI81892.1 - 0.12 12.6 15.0 0.036 14.3 7.6 2.0 1 1 1 2 2 2 0 FlgN protein GIDA_assoc_3 PF13932.1 CDI81892.1 - 0.13 12.3 2.9 0.13 12.3 0.7 2.0 2 0 0 2 2 2 0 GidA associated domain 3 bZIP_2 PF07716.10 CDI81892.1 - 0.16 11.7 7.8 0.14 12.0 2.4 2.9 3 0 0 3 3 3 0 Basic region leucine zipper Cep57_CLD_2 PF14197.1 CDI81892.1 - 0.23 11.4 6.9 1.5 8.8 4.1 2.6 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 DUF4239 PF14023.1 CDI81892.1 - 0.3 10.4 3.0 0.66 9.3 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) FlgM PF04316.8 CDI81892.1 - 2.3 8.2 9.5 18 5.3 6.3 2.6 1 1 0 1 1 1 0 Anti-sigma-28 factor, FlgM DUF4407 PF14362.1 CDI81892.1 - 4.7 6.0 16.2 5.7 5.8 8.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) M PF02370.11 CDI81892.1 - 5.7 7.6 16.6 8.8 7.0 5.1 4.1 4 0 0 4 4 3 0 M protein repeat DUF4110 PF13422.1 CDI81892.1 - 10 6.0 9.2 0.46 10.3 1.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4110) Oleosin PF01277.12 CDI81895.1 - 0.0076 15.8 0.9 0.0076 15.8 0.6 4.6 4 1 2 6 6 6 1 Oleosin Rab5ip PF07019.7 CDI81895.1 - 0.027 14.5 1.0 1.3 9.1 0.0 2.8 2 1 0 2 2 2 0 Rab5-interacting protein (Rab5ip) DUF788 PF05620.6 CDI81895.1 - 0.044 13.6 0.4 0.044 13.6 0.2 4.4 3 1 0 3 3 3 0 Protein of unknown function (DUF788) PIP5K PF01504.13 CDI81897.1 - 2.5e-24 85.7 0.3 1.2e-22 80.2 0.2 3.1 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase PAT1 PF09770.4 CDI81897.1 - 0.00056 18.2 24.2 0.00056 18.2 16.7 2.2 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 zf-DHHC PF01529.15 CDI81897.1 - 0.059 12.7 0.1 0.059 12.7 0.1 1.9 2 1 0 2 2 2 0 DHHC palmitoyltransferase MscS_TM PF12794.2 CDI81897.1 - 5.2 5.5 8.6 14 4.2 6.0 1.8 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Utp14 PF04615.8 CDI81897.1 - 5.4 5.0 41.7 1 7.4 12.3 2.1 2 0 0 2 2 2 0 Utp14 protein DUF4064 PF13273.1 CDI81900.1 - 0.47 10.6 5.5 54 3.9 3.5 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) NfeD PF01957.13 CDI81900.1 - 0.74 9.9 3.5 11 6.1 0.7 2.2 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding UQ_con PF00179.21 CDI81901.1 - 6.3e-36 122.8 0.0 7.4e-36 122.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDI81901.1 - 0.00012 21.8 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 CDI81901.1 - 0.0054 16.4 0.1 0.011 15.4 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 CDI81901.1 - 0.038 13.8 0.5 0.047 13.5 0.3 1.5 1 1 0 1 1 1 0 RWD domain RskA PF10099.4 CDI81902.1 - 0.065 12.9 0.0 0.065 12.9 0.0 5.2 2 2 2 4 4 4 0 Anti-sigma-K factor rskA DUF805 PF05656.9 CDI81902.1 - 0.32 10.8 1.9 14 5.5 1.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Myosin_head PF00063.16 CDI81904.1 - 5e-152 507.3 0.6 8.7e-152 506.6 0.4 1.3 1 1 0 1 1 1 1 Myosin head (motor domain) MFS_1 PF07690.11 CDI81906.1 - 0.017 13.8 0.0 0.024 13.3 0.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily Sugar_tr PF00083.19 CDI81906.1 - 0.23 10.0 6.8 0.099 11.1 0.1 2.7 2 1 1 3 3 3 0 Sugar (and other) transporter DUF966 PF06136.8 CDI81906.1 - 9.5 5.5 29.9 18 4.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) RRM_1 PF00076.17 CDI81907.1 - 3.5e-19 68.2 0.0 5.3e-18 64.4 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI81907.1 - 2.3e-12 46.7 0.0 1.4e-11 44.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI81907.1 - 2.3e-11 43.3 0.0 7e-08 32.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.21 CDI81907.1 - 3.4e-11 42.7 1.1 6.6e-11 41.8 0.8 1.5 1 0 0 1 1 1 1 WW domain RNA_bind PF08675.6 CDI81907.1 - 0.0095 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain Nup35_RRM PF05172.8 CDI81907.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PP-binding PF00550.20 CDI81908.1 - 3.9e-15 55.8 0.2 5.4e-15 55.4 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 CDI81908.1 - 7.6e-06 25.8 0.2 1.2e-05 25.2 0.2 1.4 1 0 0 1 1 1 1 Acyl-carrier Ribosomal_L50 PF10501.4 CDI81908.1 - 0.00081 19.3 0.2 0.0012 18.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal subunit 39S DUF1493 PF07377.7 CDI81908.1 - 0.027 14.5 0.1 0.04 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) HLH PF00010.21 CDI81908.1 - 0.069 12.8 0.0 0.084 12.5 0.0 1.3 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain CTP_transf_2 PF01467.21 CDI81910.1 - 9.6e-13 48.4 0.0 3e-12 46.8 0.0 1.9 2 0 0 2 2 2 1 Cytidylyltransferase DUF2514 PF10721.4 CDI81911.1 - 6.9 6.3 12.9 1.2 8.8 5.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Beta-Casp PF10996.3 CDI81912.1 - 0.0011 18.8 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain PI3_PI4_kinase PF00454.22 CDI81913.1 - 6.7e-22 78.1 0.2 6.4e-21 74.8 0.1 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Patched PF02460.13 CDI81913.1 - 2.5 5.8 1.2 5.1 4.8 0.8 1.4 1 0 0 1 1 1 0 Patched family YfhO PF09586.5 CDI81913.1 - 4.3 5.2 5.4 15 3.4 3.8 2.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Plasmodium_Vir PF05795.6 CDI81913.1 - 6.2 5.9 1.0 27 3.8 0.7 2.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ELO PF01151.13 CDI81915.1 - 1.9e-46 158.4 19.3 1.9e-46 158.4 13.3 2.4 2 1 0 2 2 2 1 GNS1/SUR4 family DUF1765 PF08578.5 CDI81916.1 - 4.3e-13 49.4 0.4 7.5e-13 48.6 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) SR-25 PF10500.4 CDI81916.1 - 4.3 6.7 21.5 0.081 12.3 8.9 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ycf1 PF05758.7 CDI81917.1 - 0.11 10.1 5.8 0.0075 14.0 0.4 1.6 2 0 0 2 2 2 0 Ycf1 DUF3318 PF11780.3 CDI81918.1 - 2.8 7.5 10.7 0.084 12.4 2.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3318) Myco_19_kDa PF05481.7 CDI81918.1 - 7.8 6.2 9.3 1 9.1 1.1 2.2 2 0 0 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen IncA PF04156.9 CDI81919.1 - 8.6e-06 25.4 7.6 8.6e-06 25.4 5.3 2.3 1 1 1 2 2 2 1 IncA protein Med15 PF09606.5 CDI81919.1 - 0.0052 15.0 53.2 0.0057 14.9 36.9 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Ycf1 PF05758.7 CDI81919.1 - 0.031 11.9 11.8 0.03 12.0 8.2 1.0 1 0 0 1 1 1 0 Ycf1 PAT1 PF09770.4 CDI81919.1 - 0.046 11.9 37.9 0.045 11.9 26.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Paramyxo_ncap PF00973.14 CDI81919.1 - 2.6 6.6 14.6 2.7 6.5 10.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein HemX PF04375.9 CDI81919.1 - 3.3 6.1 36.0 6.3 5.2 24.9 1.4 1 1 0 1 1 1 0 HemX TFIIA PF03153.8 CDI81919.1 - 5.4 6.8 33.7 8.4 6.1 23.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.2 CDI81919.1 - 8 4.0 18.6 8.3 3.9 12.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Utp14 PF04615.8 CDI81920.1 - 0.00076 17.7 31.1 0.00087 17.5 21.6 1.2 1 0 0 1 1 1 1 Utp14 protein TFIIF_alpha PF05793.7 CDI81920.1 - 0.0068 14.8 23.8 0.01 14.2 16.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CRT10 PF08728.5 CDI81920.1 - 0.037 12.0 10.7 0.038 11.9 7.4 1.1 1 0 0 1 1 1 0 CRT10 Caldesmon PF02029.10 CDI81920.1 - 0.059 11.7 29.9 0.12 10.7 20.7 1.5 1 0 0 1 1 1 0 Caldesmon V_ATPase_I PF01496.14 CDI81920.1 - 0.091 10.6 10.5 0.092 10.5 7.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Daxx PF03344.10 CDI81920.1 - 0.1 11.1 34.3 0.13 10.7 23.8 1.1 1 0 0 1 1 1 0 Daxx Family LMBR1 PF04791.11 CDI81920.1 - 0.9 8.0 10.3 1.1 7.7 7.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein BTV_NS2 PF04514.7 CDI81920.1 - 1.9 7.2 24.2 2.6 6.8 16.8 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 PAT1 PF09770.4 CDI81920.1 - 2 6.5 54.7 2.9 6.0 37.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF342 PF03961.8 CDI81920.1 - 7.5 4.8 22.2 10 4.3 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4045 PF13254.1 CDI81920.1 - 8.5 5.5 39.1 0.99 8.6 22.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) CHD5 PF04420.9 CDI81922.1 - 4.4e-06 26.4 1.6 6.7e-06 25.8 1.1 1.3 1 0 0 1 1 1 1 CHD5-like protein zf-ZPR1 PF03367.8 CDI81924.1 - 7.6e-63 210.4 0.0 1.9e-32 111.6 0.0 2.4 2 0 0 2 2 2 2 ZPR1 zinc-finger domain SR-25 PF10500.4 CDI81924.1 - 0.0047 16.4 18.2 0.011 15.2 12.6 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 CDI81924.1 - 0.37 9.0 15.1 0.57 8.4 10.5 1.3 1 0 0 1 1 1 0 Transmembrane protein SOBP PF15279.1 CDI81924.1 - 0.9 9.8 7.5 1.4 9.2 5.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2146 PF10220.4 CDI81924.1 - 3.1 5.6 14.8 4.6 5.0 10.3 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Med15 PF09606.5 CDI81926.1 - 0.0042 15.3 35.1 0.0056 14.9 24.3 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.4 CDI81926.1 - 0.0043 16.5 19.7 0.13 11.6 1.5 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein DUF4557 PF15101.1 CDI81926.1 - 0.025 14.4 10.8 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Suf PF05843.9 CDI81926.1 - 0.11 12.1 11.8 0.34 10.5 8.2 1.8 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) Ribosomal_60s PF00428.14 CDI81926.1 - 0.82 10.1 22.0 0.88 10.0 4.0 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein FimP PF09766.4 CDI81926.1 - 2.6 7.0 10.7 0.1 11.6 3.6 1.5 2 0 0 2 2 2 0 Fms-interacting protein Tho2 PF11262.3 CDI81928.1 - 3.2e-46 157.7 14.9 9e-46 156.2 0.0 3.2 3 1 0 3 3 3 2 Transcription factor/nuclear export subunit protein 2 DUF972 PF06156.8 CDI81929.1 - 0.018 15.4 3.1 0.018 15.4 2.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF972) ABC_tran PF00005.22 CDI81930.1 - 7.3e-08 32.8 12.3 9.2e-08 32.4 0.0 2.5 2 1 0 2 2 2 1 ABC transporter SR-25 PF10500.4 CDI81930.1 - 0.00041 19.9 9.1 0.0006 19.3 6.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AAA_21 PF13304.1 CDI81930.1 - 0.00063 19.7 0.0 0.00091 19.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain BAF1_ABF1 PF04684.8 CDI81930.1 - 0.003 16.4 12.7 0.0038 16.1 8.8 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor FCP1_C PF09309.5 CDI81930.1 - 0.04 13.2 10.6 0.069 12.4 7.3 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Ycf1 PF05758.7 CDI81930.1 - 0.042 11.5 7.4 0.054 11.2 5.1 1.0 1 0 0 1 1 1 0 Ycf1 Med15 PF09606.5 CDI81930.1 - 0.048 11.8 24.2 0.06 11.5 16.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Plasmodium_Vir PF05795.6 CDI81930.1 - 0.077 12.1 2.4 0.094 11.9 1.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FLO_LFY PF01698.11 CDI81930.1 - 0.1 11.4 6.8 0.13 11.1 4.7 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Band_3_cyto PF07565.8 CDI81930.1 - 0.16 11.4 8.3 0.22 11.0 5.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FNIP_N PF14636.1 CDI81930.1 - 0.25 11.8 14.6 2.8 8.4 7.3 2.3 2 0 0 2 2 2 0 Folliculin-interacting protein N-terminus DUF3373 PF11853.3 CDI81930.1 - 0.32 9.4 4.1 0.37 9.2 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Med13_N PF11597.3 CDI81930.1 - 0.37 9.4 9.3 0.51 8.9 6.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal PPP4R2 PF09184.6 CDI81930.1 - 0.5 9.8 12.2 0.7 9.3 8.5 1.2 1 0 0 1 1 1 0 PPP4R2 DUF4175 PF13779.1 CDI81930.1 - 0.55 7.8 26.3 0.83 7.2 18.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) MMR1 PF08505.5 CDI81930.1 - 0.8 9.6 15.2 1.3 8.9 10.5 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Serinc PF03348.10 CDI81930.1 - 0.85 8.2 7.4 1.1 7.8 5.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Gti1_Pac2 PF09729.4 CDI81930.1 - 0.87 9.4 5.9 1.4 8.7 4.1 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family TFIIA PF03153.8 CDI81930.1 - 1.3 8.8 21.5 1.8 8.3 14.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Usp PF00582.21 CDI81930.1 - 1.5 8.9 4.3 2.4 8.3 2.1 2.0 2 0 0 2 2 2 0 Universal stress protein family DUF4407 PF14362.1 CDI81930.1 - 1.7 7.5 11.1 2.4 7.0 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Glyco_transf_15 PF01793.11 CDI81930.1 - 2.3 7.0 6.1 3.3 6.5 4.2 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase LIM_bind PF01803.11 CDI81930.1 - 2.8 6.9 11.9 36 3.3 7.3 2.1 2 0 0 2 2 2 0 LIM-domain binding protein 60KD_IMP PF02096.15 CDI81930.1 - 4.8 6.8 10.8 8.8 5.9 7.5 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein SpoIIIAH PF12685.2 CDI81930.1 - 6.2 6.2 15.8 8.7 5.7 10.9 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF912 PF06024.7 CDI81930.1 - 7.4 6.6 6.5 16 5.5 4.5 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TRAPPC10 PF12584.3 CDI81932.1 - 1.2e-05 24.8 0.0 8.8e-05 22.0 0.0 2.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Ribosomal_L30 PF00327.15 CDI81933.1 - 0.00035 20.1 0.5 0.0011 18.5 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e TRM PF02005.11 CDI81934.1 - 2e-84 283.6 0.0 4e-44 151.0 0.0 3.1 3 0 0 3 3 3 3 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_26 PF13659.1 CDI81934.1 - 0.012 15.6 8.4 0.051 13.6 5.8 2.1 1 1 0 1 1 1 0 Methyltransferase domain DUF2217 PF10265.4 CDI81934.1 - 1.3 7.6 10.3 2.3 6.8 7.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) CpXC PF14353.1 CDI81934.1 - 2.2 8.2 5.1 0.34 10.8 0.6 1.9 2 0 0 2 2 2 0 CpXC protein Nop14 PF04147.7 CDI81935.1 - 0.042 11.7 11.9 0.06 11.2 8.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1510 PF07423.6 CDI81935.1 - 0.89 8.8 16.8 1.6 8.0 11.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Daxx PF03344.10 CDI81935.1 - 1.1 7.5 15.8 2.2 6.6 11.0 1.3 1 0 0 1 1 1 0 Daxx Family Tau95 PF09734.4 CDI81937.1 - 1.9e-23 83.2 0.2 3.4e-13 49.6 0.0 2.9 3 0 0 3 3 3 2 RNA polymerase III transcription factor (TF)IIIC subunit Med15 PF09606.5 CDI81937.1 - 0.22 9.6 50.9 0.015 13.5 19.9 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal RAB3GAP2_N PF14655.1 CDI81937.1 - 2.3 7.1 16.4 0.055 12.4 2.5 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus GDI PF00996.13 CDI81938.1 - 7.3e-20 70.6 0.0 1.7e-08 33.1 0.0 3.9 4 0 0 4 4 4 3 GDP dissociation inhibitor DUF3801 PF12687.2 CDI81938.1 - 0.0011 18.5 0.2 0.0011 18.5 0.1 5.3 5 1 0 5 5 5 1 Protein of unknown function (DUF3801) CR6_interact PF10147.4 CDI81940.1 - 0.009 15.3 1.4 0.015 14.5 0.4 1.8 2 0 0 2 2 2 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Ank PF00023.25 CDI81941.1 - 2.9e-27 93.0 4.8 5.6e-09 35.3 0.1 6.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 CDI81941.1 - 8.4e-27 93.3 0.6 3.5e-21 75.3 0.1 3.2 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDI81941.1 - 6e-23 80.7 0.9 2.1e-11 44.0 0.1 5.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI81941.1 - 2e-19 67.7 4.8 5e-06 26.2 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 CDI81941.1 - 3.9e-16 58.6 7.0 1.8e-11 43.8 0.2 5.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) SET PF00856.23 CDI81941.1 - 0.0058 16.9 0.0 0.02 15.2 0.0 1.9 1 0 0 1 1 1 1 SET domain AAA PF00004.24 CDI81944.1 - 1.3e-26 93.4 0.1 4.5e-26 91.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 CDI81944.1 - 0.051 13.4 0.1 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF1640 PF07798.6 CDI81944.1 - 0.076 13.0 0.5 0.15 12.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF904 PF06005.7 CDI81944.1 - 0.16 12.2 3.7 0.23 11.7 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Exo_endo_phos PF03372.18 CDI81945.1 - 6.7e-18 65.5 1.1 1.5e-16 61.0 0.0 2.2 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Mt_ATP-synt_D PF05873.7 CDI81947.1 - 0.19 11.3 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) DUF2217 PF10265.4 CDI81950.1 - 0.029 13.1 10.7 0.036 12.8 7.4 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) His_Phos_2 PF00328.17 CDI81950.1 - 0.037 13.3 10.9 0.052 12.8 7.5 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) CDC27 PF09507.5 CDI81950.1 - 0.13 11.4 23.6 0.17 11.0 16.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF812 PF05667.6 CDI81950.1 - 0.3 9.5 24.0 0.35 9.3 16.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) BTV_NS2 PF04514.7 CDI81950.1 - 0.32 9.8 15.7 0.4 9.4 10.9 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Cwf_Cwc_15 PF04889.7 CDI81950.1 - 0.41 10.3 23.3 0.61 9.7 16.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FLO_LFY PF01698.11 CDI81950.1 - 0.49 9.1 17.8 0.58 8.9 12.3 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Exonuc_VII_L PF02601.10 CDI81950.1 - 1 8.4 18.2 1.3 8.1 12.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PPP4R2 PF09184.6 CDI81950.1 - 1.1 8.7 17.7 1.4 8.3 12.3 1.3 1 0 0 1 1 1 0 PPP4R2 DUF3337 PF11816.3 CDI81950.1 - 1.4 8.2 15.1 1.7 7.9 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) SR-25 PF10500.4 CDI81950.1 - 1.6 8.1 23.3 1.3 8.4 15.4 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SAPS PF04499.10 CDI81950.1 - 2.1 6.8 15.7 2.8 6.4 10.9 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Peptidase_S64 PF08192.6 CDI81950.1 - 3.1 6.0 16.4 3.5 5.8 11.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 RR_TM4-6 PF06459.7 CDI81950.1 - 3.5 7.4 19.8 4.6 7.0 13.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.8 CDI81950.1 - 4.2 7.1 37.4 5.6 6.7 25.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI81950.1 - 4.9 5.2 43.5 5.3 5.1 30.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Parvo_coat PF00740.13 CDI81950.1 - 5.5 5.8 20.3 6.5 5.5 14.1 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 MRP-S31 PF15433.1 CDI81950.1 - 6.8 6.0 21.2 8.8 5.6 14.7 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Apt1 PF10351.4 CDI81950.1 - 7.3 5.3 18.8 9.4 4.9 13.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Asp-B-Hydro_N PF05279.6 CDI81950.1 - 9.7 5.9 16.9 13 5.5 11.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Acyltransferase PF01553.16 CDI81951.1 - 5.6e-07 29.0 0.1 0.00092 18.6 0.0 2.4 2 0 0 2 2 2 2 Acyltransferase BAF1_ABF1 PF04684.8 CDI81951.1 - 0.0014 17.5 11.3 0.0014 17.5 7.8 6.1 2 1 4 6 6 6 1 BAF1 / ABF1 chromatin reorganising factor Mucin PF01456.12 CDI81951.1 - 0.0091 15.7 15.7 0.0091 15.7 10.9 4.4 3 1 0 4 4 4 1 Mucin-like glycoprotein Ku_N PF03731.10 CDI81953.1 - 0.00065 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Kei1 PF08552.6 CDI81953.1 - 0.073 12.7 3.4 5.6 6.5 0.6 2.2 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3446 PF11928.3 CDI81953.1 - 0.27 11.4 26.3 1.8 8.7 5.5 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) Secretin_N_2 PF07655.8 CDI81953.1 - 0.29 11.5 25.8 1.1 9.6 9.6 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain DUF4614 PF15391.1 CDI81953.1 - 0.79 9.4 12.5 3.6 7.3 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) MACPF PF01823.14 CDI81953.1 - 1.7 8.2 14.8 0.43 10.2 1.9 2.2 2 0 0 2 2 2 0 MAC/Perforin domain SR-25 PF10500.4 CDI81953.1 - 1.8 7.9 40.6 0.093 12.1 8.5 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein POX PF07526.6 CDI81953.1 - 2.8 8.1 7.5 11 6.2 0.2 2.3 2 0 0 2 2 2 0 Associated with HOX PBP1_TM PF14812.1 CDI81957.1 - 2 8.7 16.2 2.1 8.6 11.2 1.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Kinesin PF00225.18 CDI81958.1 - 2.3e-09 36.3 0.0 5.1e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain BAF1_ABF1 PF04684.8 CDI81959.1 - 0.0022 16.9 17.5 0.0022 16.9 12.1 2.9 1 1 1 3 3 2 1 BAF1 / ABF1 chromatin reorganising factor DUF755 PF05501.6 CDI81959.1 - 0.027 14.5 30.0 0.027 14.5 20.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Peptidase_S49_N PF08496.5 CDI81959.1 - 0.11 12.2 10.7 1.1 9.0 0.5 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal U79_P34 PF03064.11 CDI81959.1 - 0.16 11.4 14.8 0.016 14.7 3.3 2.0 2 0 0 2 2 2 0 HSV U79 / HCMV P34 DUF2681 PF10883.3 CDI81959.1 - 0.41 10.8 21.0 0.099 12.8 2.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Pap_E4 PF02711.9 CDI81959.1 - 0.51 11.1 16.6 2.7 8.8 7.0 2.2 2 0 0 2 2 2 0 E4 protein RskA PF10099.4 CDI81959.1 - 0.78 9.4 27.7 0.17 11.5 5.5 2.3 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Cwf_Cwc_15 PF04889.7 CDI81959.1 - 0.91 9.1 16.0 0.9 9.1 5.2 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2052 PF09747.4 CDI81959.1 - 1.7 8.5 17.6 2.2 8.1 6.7 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) FimP PF09766.4 CDI81959.1 - 1.9 7.4 21.9 2.5 7.1 4.9 2.1 2 0 0 2 2 2 0 Fms-interacting protein Activator_LAG-3 PF11498.3 CDI81959.1 - 2.1 7.0 40.0 0.39 9.3 7.5 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Pex16 PF08610.5 CDI81959.1 - 2.7 6.9 12.9 7 5.5 0.2 2.0 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) DUF3807 PF12720.2 CDI81959.1 - 2.7 8.1 21.1 2.7 8.1 5.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF1635 PF07795.6 CDI81959.1 - 3.3 7.0 22.6 4.5 6.5 8.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF1183 PF06682.7 CDI81959.1 - 3.5 7.1 18.0 0.7 9.4 6.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) DUF4557 PF15101.1 CDI81959.1 - 4.3 7.1 27.2 4.4 7.0 4.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Ribosomal_60s PF00428.14 CDI81959.1 - 4.6 7.7 23.5 0.42 11.0 4.1 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein HEXIM PF15313.1 CDI81959.1 - 8.1 6.6 14.7 3.1 7.9 5.2 2.3 2 1 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein RAP1 PF07218.6 CDI81959.1 - 8.2 4.3 11.3 10 4.0 7.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RAB3GAP2_N PF14655.1 CDI81960.1 - 4.3 6.2 6.8 8.7 5.2 0.9 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Phostensin_N PF13916.1 CDI81960.1 - 4.9 7.2 13.1 16 5.5 2.5 3.1 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DUF21 PF01595.15 CDI81961.1 - 3.2e-12 46.0 1.6 3.7e-12 45.9 0.6 1.5 2 0 0 2 2 2 1 Domain of unknown function DUF21 YrhC PF14143.1 CDI81961.1 - 0.00081 19.2 1.7 0.0014 18.5 1.2 1.3 1 0 0 1 1 1 1 YrhC-like protein Transposase_28 PF04195.7 CDI81961.1 - 0.026 13.7 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative gypsy type transposon DUF3650 PF12368.3 CDI81965.1 - 0.063 12.7 0.3 0.18 11.3 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3650) Mod_r PF07200.8 CDI81965.1 - 3.4 7.5 7.7 0.64 9.9 0.1 2.4 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Glyoxalase_3 PF13468.1 CDI81967.1 - 0.0018 18.2 0.4 0.0046 16.8 0.3 1.7 1 0 0 1 1 1 1 Glyoxalase-like domain Activator_LAG-3 PF11498.3 CDI81969.1 - 0.5 9.0 15.6 0.55 8.9 10.8 1.0 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Ras PF00071.17 CDI81970.1 - 1.3e-36 125.4 0.1 8.9e-19 67.4 0.0 2.1 2 0 0 2 2 2 2 Ras family Miro PF08477.8 CDI81970.1 - 4.1e-07 30.4 0.1 0.00016 22.1 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein Arf PF00025.16 CDI81970.1 - 0.0097 15.1 0.1 3.1 7.0 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF258 PF03193.11 CDI81970.1 - 0.032 13.4 0.0 0.062 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 CDI81970.1 - 0.12 12.5 0.1 1.2 9.2 0.0 2.3 3 0 0 3 3 3 0 AAA domain Suf PF05843.9 CDI81971.1 - 6e-05 22.9 0.4 0.0014 18.4 0.2 2.1 1 1 1 2 2 2 2 Suppressor of forked protein (Suf) TPR_11 PF13414.1 CDI81971.1 - 0.0061 16.1 0.5 0.0092 15.6 0.3 1.3 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.1 CDI81971.1 - 0.0076 16.1 1.7 0.024 14.5 0.8 2.0 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI81971.1 - 0.0083 15.9 3.6 0.39 10.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDI81971.1 - 0.0086 16.6 4.4 0.94 10.2 1.5 2.4 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDI81971.1 - 0.0097 16.5 4.0 0.014 16.0 2.6 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat HAT PF02184.11 CDI81971.1 - 0.049 13.3 9.6 5.2 6.8 0.2 4.0 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat Ribosomal_S25 PF03297.10 CDI81978.1 - 1.5e-41 140.6 1.4 1.7e-41 140.5 0.9 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.2 CDI81978.1 - 0.039 13.6 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 MarR family Trp_halogenase PF04820.9 CDI81978.1 - 0.12 10.9 0.1 0.14 10.7 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Rrf2 PF02082.15 CDI81978.1 - 0.13 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator IFRD PF05004.8 CDI81979.1 - 0.074 12.1 3.2 0.13 11.3 2.2 1.3 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) TSA PF03249.8 CDI81979.1 - 0.46 8.9 3.3 0.65 8.4 2.3 1.1 1 0 0 1 1 1 0 Type specific antigen CopD PF05425.8 CDI81979.1 - 0.64 10.2 8.3 1.3 9.3 5.8 1.5 1 0 0 1 1 1 0 Copper resistance protein D E_Pc_C PF06752.7 CDI81979.1 - 0.75 9.2 5.6 1.4 8.3 3.9 1.4 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus OAD_gamma PF04277.8 CDI81980.1 - 0.14 12.5 2.2 0.53 10.7 0.0 2.9 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF2362 PF10154.4 CDI81982.1 - 5e-05 22.1 0.0 0.00032 19.5 0.0 3.9 5 1 0 5 5 5 2 Uncharacterized conserved protein (DUF2362) DUF2366 PF10171.4 CDI81982.1 - 0.25 10.7 0.2 0.5 9.8 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2366) Ank_2 PF12796.2 CDI81983.1 - 7.2e-09 35.8 0.1 4e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 CDI81983.1 - 1.6e-05 24.4 1.1 0.0011 18.6 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 CDI81983.1 - 0.0002 21.7 0.0 0.0006 20.2 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDI81983.1 - 0.0009 19.4 0.4 0.0045 17.1 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI81983.1 - 0.026 14.7 0.0 0.24 11.7 0.0 2.7 1 0 0 1 1 1 0 Ankyrin repeat DENN PF02141.16 CDI81985.1 - 4.9e-09 36.1 13.9 2.3e-08 33.9 1.4 2.9 3 0 0 3 3 3 2 DENN (AEX-3) domain uDENN PF03456.13 CDI81985.1 - 1.1e-06 28.5 5.0 2.2e-05 24.3 0.1 3.3 3 0 0 3 3 3 2 uDENN domain LSM PF01423.17 CDI81987.1 - 3e-15 55.4 0.8 3.9e-15 55.1 0.6 1.1 1 0 0 1 1 1 1 LSM domain DUF3093 PF11292.3 CDI81989.1 - 0.052 13.3 5.0 0.056 13.2 0.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3093) UPF0546 PF10639.4 CDI81991.1 - 6.4e-16 58.1 0.2 7.2e-16 58.0 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0546 FA_desaturase PF00487.19 CDI81991.1 - 0.12 11.7 0.7 0.13 11.7 0.5 1.0 1 0 0 1 1 1 0 Fatty acid desaturase Kinase-like PF14531.1 CDI81992.1 - 1.7e-11 43.6 0.0 8.3e-11 41.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.20 CDI81992.1 - 2.9e-08 33.1 0.0 5.9e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI81992.1 - 0.0017 17.5 0.0 0.0031 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase bZIP_Maf PF03131.12 CDI81992.1 - 2.7 8.3 14.7 5.4 7.3 10.2 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor RrnaAD PF00398.15 CDI81993.1 - 7.9e-23 80.8 0.0 9.5e-23 80.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 CDI81993.1 - 2.4e-08 34.0 0.0 4.2e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI81993.1 - 3e-07 30.1 0.0 4e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDI81993.1 - 2.2e-05 23.8 0.0 3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CDI81993.1 - 4e-05 23.9 0.0 6.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI81993.1 - 9.4e-05 22.9 0.0 0.00013 22.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI81993.1 - 0.001 19.5 0.0 0.0016 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDI81993.1 - 0.0012 19.2 0.0 0.002 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI81993.1 - 0.0019 17.9 0.0 0.0024 17.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.11 CDI81993.1 - 0.0037 16.2 0.0 0.0053 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF43 Ubie_methyltran PF01209.13 CDI81993.1 - 0.0039 16.3 0.0 0.0049 16.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family AAA_19 PF13245.1 CDI81993.1 - 0.011 15.4 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Methyltransf_4 PF02390.12 CDI81993.1 - 0.017 14.1 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.6 CDI81993.1 - 0.024 14.0 0.0 0.033 13.5 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) PCMT PF01135.14 CDI81993.1 - 0.025 14.1 0.0 0.034 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.10 CDI81993.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DREV PF05219.7 CDI81993.1 - 0.12 11.2 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Spc97_Spc98 PF04130.8 CDI81994.1 - 1e-20 73.5 0.0 3.3e-20 71.9 0.0 1.7 2 0 0 2 2 2 1 Spc97 / Spc98 family PHD PF00628.24 CDI81995.1 - 5.1e-06 26.0 5.1 5.1e-06 26.0 3.5 2.4 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.1 CDI81995.1 - 1.3 8.3 16.5 0.071 12.4 5.3 2.6 2 0 0 2 2 2 0 PHD-finger FGE-sulfatase PF03781.11 CDI82002.1 - 0.023 14.0 0.3 0.039 13.3 0.2 1.3 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 V-SNARE_C PF12352.3 CDI82003.1 - 1.3e-06 28.3 0.2 9e-06 25.6 0.2 2.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Pkinase PF00069.20 CDI82004.1 - 1.9e-10 40.3 0.0 1.9e-10 40.3 0.0 2.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82004.1 - 2.8e-07 29.8 0.0 1.5e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Ycf1 PF05758.7 CDI82004.1 - 2.4 5.7 14.9 0.9 7.1 0.6 2.5 2 0 0 2 2 2 0 Ycf1 Notch PF00066.12 CDI82006.1 - 7.1e-09 35.7 8.8 5e-08 33.0 6.1 2.7 1 0 0 1 1 1 1 LNR domain Big_5 PF13205.1 CDI82006.1 - 1.7e-05 25.3 0.0 1.5 9.4 0.0 4.4 3 1 0 3 3 3 1 Bacterial Ig-like domain EphA2_TM PF14575.1 CDI82006.1 - 0.23 11.8 0.6 19 5.7 0.0 2.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ctr PF04145.10 CDI82006.1 - 0.3 11.1 0.6 24 4.9 0.0 3.3 2 0 0 2 2 2 0 Ctr copper transporter family lci PF12197.3 CDI82006.1 - 0.46 10.1 0.0 1 9.0 0.0 1.5 1 0 0 1 1 1 0 Bacillus cereus group antimicrobial protein 7tm_1 PF00001.16 CDI82006.1 - 0.68 9.0 0.1 8.3 5.4 0.0 2.1 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF1049 PF06305.6 CDI82006.1 - 1 8.9 12.5 0.021 14.2 1.0 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) F420_oxidored PF03807.12 CDI82010.1 - 6.7e-06 26.4 0.0 2e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 CDI82010.1 - 1.8e-05 24.5 0.1 2.9e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PDH PF02153.12 CDI82010.1 - 0.0022 16.9 0.0 0.0033 16.3 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase Pyr_redox PF00070.22 CDI82010.1 - 0.031 14.6 0.0 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Semialdhyde_dh PF01118.19 CDI82010.1 - 0.036 14.3 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain ApbA PF02558.11 CDI82010.1 - 0.054 12.9 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.17 CDI82010.1 - 0.056 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.7 CDI82010.1 - 0.078 12.3 0.0 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_7 PF13241.1 CDI82010.1 - 0.12 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding BAF1_ABF1 PF04684.8 CDI82011.1 - 0.00013 20.9 31.4 0.00019 20.4 21.8 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor FimP PF09766.4 CDI82011.1 - 0.00025 20.2 6.3 0.00031 19.9 4.4 1.2 1 0 0 1 1 1 1 Fms-interacting protein Pex14_N PF04695.8 CDI82011.1 - 0.0015 18.5 12.6 0.0026 17.8 8.7 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.3 CDI82011.1 - 0.0053 16.1 4.2 0.0093 15.3 2.9 1.4 1 0 0 1 1 1 1 Spt20 family MDFI PF15316.1 CDI82011.1 - 0.0091 16.0 2.9 0.013 15.4 2.0 1.2 1 0 0 1 1 1 1 MyoD family inhibitor DUF4401 PF14351.1 CDI82011.1 - 0.011 14.6 3.5 0.016 14.2 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) PAT1 PF09770.4 CDI82011.1 - 0.021 13.1 17.1 0.027 12.7 11.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RIC3 PF15361.1 CDI82011.1 - 0.025 14.8 3.7 0.025 14.8 2.5 1.6 2 0 0 2 2 1 0 Resistance to inhibitors of cholinesterase homologue 3 FCP1_C PF09309.5 CDI82011.1 - 0.029 13.6 2.8 0.044 13.0 1.9 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Band_3_cyto PF07565.8 CDI82011.1 - 0.04 13.4 4.7 0.049 13.1 3.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pex16 PF08610.5 CDI82011.1 - 0.047 12.6 2.8 0.92 8.4 1.3 2.2 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) Baculo_PP31 PF05311.6 CDI82011.1 - 0.076 12.2 3.7 0.12 11.6 2.5 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF912 PF06024.7 CDI82011.1 - 0.093 12.7 3.1 0.057 13.4 0.9 1.7 2 0 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) EOS1 PF12326.3 CDI82011.1 - 0.16 11.5 0.7 3.3 7.3 0.0 2.2 2 0 0 2 2 2 0 N-glycosylation protein CD20 PF04103.10 CDI82011.1 - 0.18 11.6 7.0 0.35 10.7 2.1 2.2 1 1 0 2 2 2 0 CD20-like family Ribonuclease_3 PF00636.21 CDI82011.1 - 0.24 11.8 2.1 0.44 11.0 1.4 1.6 1 1 0 1 1 1 0 Ribonuclease III domain Activator_LAG-3 PF11498.3 CDI82011.1 - 0.86 8.2 32.7 1.1 7.8 22.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TMEM51 PF15345.1 CDI82011.1 - 0.91 9.1 8.5 1.5 8.4 5.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 MCR_alpha PF02249.12 CDI82011.1 - 1.4 8.9 16.4 8.1 6.4 11.5 2.2 1 1 1 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain DUF3371 PF11851.3 CDI82011.1 - 1.8 9.2 14.8 3.2 8.4 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Gag_spuma PF03276.9 CDI82011.1 - 2.7 6.2 17.5 4.2 5.5 12.2 1.2 1 0 0 1 1 1 0 Spumavirus gag protein DUF4192 PF13830.1 CDI82011.1 - 7.2 6.1 23.4 11 5.6 16.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) PLC-beta_C PF08703.5 CDI82014.1 - 0.0043 16.7 3.2 0.74 9.4 0.3 2.6 2 0 0 2 2 2 2 PLC-beta C terminal Conotoxin PF02950.12 CDI82016.1 - 0.29 11.9 0.0 0.29 11.9 0.0 3.3 3 0 0 3 3 3 0 Conotoxin DUF1183 PF06682.7 CDI82016.1 - 0.99 8.9 13.7 7 6.1 0.0 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1183) Pex14_N PF04695.8 CDI82017.1 - 9.5 6.2 11.9 0.24 11.4 1.9 2.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ATP-synt_10 PF05176.9 CDI82018.1 - 0.041 13.1 0.0 2.5 7.2 0.0 2.2 1 1 1 2 2 2 0 ATP10 protein DUF2703 PF10865.3 CDI82018.1 - 0.054 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) Transport_MerF PF11431.3 CDI82018.1 - 0.063 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Membrane transport protein MerF DHC_N2 PF08393.8 CDI82019.1 - 3.7e-100 335.2 3.0 7.1e-100 334.3 0.9 2.2 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 CDI82019.1 - 4.6e-84 281.5 0.6 1.6e-83 279.7 0.1 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 CDI82019.1 - 3.1e-50 170.7 0.0 6.7e-50 169.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 CDI82019.1 - 3.4e-19 68.9 0.0 2.5e-06 27.2 0.0 6.3 6 1 0 6 6 5 2 AAA domain (dynein-related subfamily) AAA_8 PF12780.2 CDI82019.1 - 3.5e-17 62.2 0.0 6.4e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA PF00004.24 CDI82019.1 - 2.2e-06 27.9 0.0 0.0095 16.1 0.0 3.9 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CDI82019.1 - 0.00019 21.1 0.5 0.11 12.2 0.1 3.1 3 0 0 3 3 2 1 Part of AAA domain AAA_22 PF13401.1 CDI82019.1 - 0.0003 20.9 0.5 4.2 7.5 0.0 4.3 4 0 0 4 4 4 2 AAA domain AAA_17 PF13207.1 CDI82019.1 - 0.00034 21.4 0.2 0.012 16.4 0.0 3.5 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.1 CDI82019.1 - 0.0012 18.9 1.6 6.3 6.7 0.0 5.0 4 1 1 5 5 5 1 AAA ATPase domain DUF853 PF05872.7 CDI82019.1 - 0.0024 16.2 0.7 0.15 10.3 0.0 2.2 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) Zeta_toxin PF06414.7 CDI82019.1 - 0.017 14.2 0.0 0.054 12.5 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 CDI82019.1 - 0.018 15.1 0.0 0.23 11.6 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.1 CDI82019.1 - 0.025 14.1 0.1 0.94 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CDI82019.1 - 0.028 13.8 0.7 1.9 7.8 0.1 2.7 2 0 0 2 2 2 0 AAA domain PriCT_1 PF08708.6 CDI82019.1 - 0.035 13.9 0.0 9.7 6.0 0.0 3.4 3 0 0 3 3 2 0 Primase C terminal 1 (PriCT-1) AAA_18 PF13238.1 CDI82019.1 - 0.07 13.4 0.1 0.39 11.0 0.0 2.4 2 0 0 2 2 1 0 AAA domain T2SE PF00437.15 CDI82019.1 - 0.078 11.8 0.7 0.77 8.5 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein DEAD PF00270.24 CDI82019.1 - 0.078 12.4 0.0 0.44 10.0 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase UPF0079 PF02367.12 CDI82019.1 - 0.095 12.3 0.4 4.1 7.0 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 CDI82019.1 - 0.11 11.6 0.2 6 5.9 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI rve_2 PF13333.1 CDI82019.1 - 0.12 12.4 1.4 0.46 10.5 0.5 2.4 2 0 0 2 2 1 0 Integrase core domain MT PF12777.2 CDI82020.1 - 2.6e-42 144.8 7.8 4.9e-40 137.3 2.0 2.1 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 CDI82020.1 - 2.1e-30 105.2 8.1 7e-17 61.0 0.1 3.0 2 1 1 3 3 3 2 ATP-binding dynein motor region D5 GrpE PF01025.14 CDI82020.1 - 0.0093 15.5 1.9 0.0093 15.5 1.3 3.6 3 1 0 3 3 3 1 GrpE TPR_10 PF13374.1 CDI82020.1 - 0.017 15.0 1.5 0.16 11.9 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MEDS PF14417.1 CDI82020.1 - 0.018 14.1 1.5 0.035 13.1 0.1 2.1 2 0 0 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain TPR_12 PF13424.1 CDI82020.1 - 0.054 13.4 1.6 1.8 8.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat V_ATPase_I PF01496.14 CDI82020.1 - 0.12 10.2 7.3 0.079 10.8 0.4 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TPR_2 PF07719.12 CDI82020.1 - 0.16 11.9 2.5 13 6.0 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Spc7 PF08317.6 CDI82020.1 - 1.5 7.3 20.3 0.051 12.2 2.4 2.8 3 0 0 3 3 3 0 Spc7 kinetochore protein IncA PF04156.9 CDI82020.1 - 5.9 6.4 25.0 0.32 10.5 1.1 3.2 3 0 0 3 3 3 0 IncA protein APG6 PF04111.7 CDI82020.1 - 6.4 5.7 24.4 0.84 8.6 1.6 3.2 3 0 0 3 3 3 0 Autophagy protein Apg6 Transposase_22 PF02994.9 CDI82020.1 - 7.4 4.9 13.8 0.072 11.5 0.1 3.2 3 1 0 3 3 3 0 L1 transposable element Dynein_heavy PF03028.10 CDI82021.1 - 4.3e-116 388.6 0.0 1.4e-96 324.1 0.0 2.0 1 1 1 2 2 2 2 Dynein heavy chain and region D6 of dynein motor Creb_binding PF09030.5 CDI82024.1 - 0.00062 19.9 2.2 0.00062 19.9 1.5 2.2 2 0 0 2 2 2 2 Creb binding SF-assemblin PF06705.6 CDI82026.1 - 0.0014 17.8 4.8 0.0014 17.8 3.3 2.8 1 1 2 3 3 3 3 SF-assemblin/beta giardin RVT_N PF13655.1 CDI82026.1 - 0.035 14.1 4.8 1.4 9.0 0.7 2.7 2 1 0 2 2 2 0 N-terminal domain of reverse transcriptase FMN_dh PF01070.13 CDI82026.1 - 0.11 11.2 4.4 0.13 11.0 3.1 1.1 1 0 0 1 1 1 0 FMN-dependent dehydrogenase PTPlike_phytase PF14566.1 CDI82026.1 - 0.19 11.7 10.3 0.33 10.9 6.3 2.0 1 1 1 2 2 2 0 Inositol hexakisphosphate SPOB_ab PF14682.1 CDI82026.1 - 1 9.1 4.9 16 5.3 0.1 2.8 1 1 2 3 3 3 0 Sporulation initiation phospho-transferase B, C-terminal CorA PF01544.13 CDI82026.1 - 2.7 6.9 8.6 0.87 8.5 1.3 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein CR6_interact PF10147.4 CDI82026.1 - 3.2 6.9 15.2 0.22 10.8 6.6 1.8 1 1 1 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Brr6_like_C_C PF10104.4 CDI82026.1 - 3.8 7.0 6.4 18 4.8 0.1 2.1 1 1 1 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain Orbi_VP5 PF00901.12 CDI82026.1 - 4.2 5.4 19.9 3.9 5.5 0.7 2.6 1 1 1 2 2 2 0 Orbivirus outer capsid protein VP5 FlgN PF05130.7 CDI82026.1 - 6.1 7.0 28.0 0.64 10.2 15.2 2.0 1 1 1 2 2 2 0 FlgN protein V_ATPase_I PF01496.14 CDI82026.1 - 8 4.1 8.7 11 3.6 6.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7_N PF15402.1 CDI82028.1 - 0.18 9.7 36.4 0.24 9.3 25.2 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PAT1 PF09770.4 CDI82028.1 - 0.53 8.4 74.4 0.7 8.0 51.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MIP-T3 PF10243.4 CDI82028.1 - 1.4 7.2 56.3 2.5 6.4 39.0 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3523 PF12037.3 CDI82028.1 - 3.3 6.6 63.8 0.033 13.1 20.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3523) Suf PF05843.9 CDI82028.1 - 3.8 7.1 49.1 1.8 8.2 16.0 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) MRP-S31 PF15433.1 CDI82028.1 - 4.2 6.6 40.1 0.82 9.0 14.5 2.2 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Pinin_SDK_memA PF04696.8 CDI82030.1 - 0.056 13.0 0.2 0.056 13.0 0.1 1.9 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region PUA PF01472.15 CDI82032.1 - 6.1e-06 25.8 0.0 1.4e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 PUA domain UEV PF05743.8 CDI82032.1 - 0.15 11.7 0.2 0.63 9.7 0.2 1.9 1 1 0 1 1 1 0 UEV domain DUF2077 PF09850.4 CDI82035.1 - 0.85 8.9 8.3 0.29 10.5 0.2 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2077) DUF912 PF06024.7 CDI82035.1 - 1.1 9.3 3.3 38 4.3 0.0 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Suf PF05843.9 CDI82035.1 - 1.2 8.8 7.4 2 8.0 5.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FimP PF09766.4 CDI82035.1 - 1.4 7.8 11.2 2.1 7.3 7.8 1.1 1 0 0 1 1 1 0 Fms-interacting protein TMEM154 PF15102.1 CDI82035.1 - 2.2 7.9 10.9 29 4.3 0.0 2.6 2 0 0 2 2 2 0 TMEM154 protein family DUF1625 PF07787.7 CDI82036.1 - 0.0027 17.0 0.2 0.041 13.1 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1625) tRNA-synt_1c PF00749.16 CDI82037.1 - 0.021 13.5 3.2 0.027 13.1 0.4 2.3 2 1 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Late_protein_L1 PF00500.13 CDI82037.1 - 0.043 12.3 1.2 0.082 11.4 0.9 1.4 1 1 0 1 1 1 0 L1 (late) protein PAT1 PF09770.4 CDI82037.1 - 0.7 8.0 21.3 0.96 7.6 14.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3391 PF11871.3 CDI82037.1 - 4.5 7.4 14.6 0.67 10.1 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) DUF4239 PF14023.1 CDI82037.1 - 5.1 6.3 6.6 0.43 9.8 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) PsaN PF05479.6 CDI82038.1 - 1.9 8.4 10.5 6 6.8 7.3 1.8 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Ycf1 PF05758.7 CDI82038.1 - 9.2 3.8 19.4 0.86 7.2 8.2 2.2 2 0 0 2 2 2 0 Ycf1 Abhydrolase_6 PF12697.2 CDI82040.1 - 1e-19 71.3 0.0 7.3e-19 68.5 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDI82040.1 - 2.2e-07 30.7 0.3 0.00014 21.6 0.0 2.6 2 1 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI82040.1 - 1.1e-05 25.1 7.3 0.027 14.0 3.1 2.6 2 1 0 2 2 2 2 alpha/beta hydrolase fold DUF755 PF05501.6 CDI82040.1 - 0.0049 16.9 15.2 0.0049 16.9 10.5 6.9 6 1 0 6 6 6 1 Domain of unknown function (DUF755) Abhydrolase_4 PF08386.5 CDI82040.1 - 0.0067 16.2 0.0 0.026 14.3 0.0 1.9 1 0 0 1 1 1 1 TAP-like protein DUF844 PF05815.6 CDI82040.1 - 0.15 10.9 1.8 0.44 9.3 1.2 1.7 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) PAF-AH_p_II PF03403.8 CDI82040.1 - 0.17 10.1 0.0 0.17 10.1 0.0 2.0 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF1178 PF06676.6 CDI82040.1 - 2.2 8.4 11.7 0.59 10.3 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Oxysterol_BP PF01237.13 CDI82041.1 - 4.9e-70 235.7 0.0 6.5e-49 166.2 0.0 3.7 1 1 2 3 3 3 3 Oxysterol-binding protein PH PF00169.24 CDI82041.1 - 1.9e-10 40.8 0.2 3.7e-10 39.9 0.2 1.5 1 0 0 1 1 1 1 PH domain IncA PF04156.9 CDI82041.1 - 0.0053 16.3 1.6 0.0053 16.3 1.1 7.6 7 1 0 7 7 7 2 IncA protein PH_11 PF15413.1 CDI82041.1 - 0.25 11.6 2.5 16 5.8 1.7 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain DUF4463 PF14703.1 CDI82046.1 - 0.32 11.5 2.8 1.1 9.7 1.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4463) Tetraspannin PF00335.15 CDI82046.1 - 0.45 9.7 15.5 0.93 8.7 10.7 1.5 1 0 0 1 1 1 0 Tetraspanin family Rnk_N PF14760.1 CDI82046.1 - 9.1 6.4 11.7 2.5 8.2 1.7 3.2 3 0 0 3 3 3 0 Rnk N-terminus RNA_pol_Rpb1_5 PF04998.12 CDI82047.1 - 5.9e-18 65.1 1.1 8.6e-18 64.5 0.7 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RAB3GAP2_N PF14655.1 CDI82047.1 - 0.0046 16.0 0.3 0.0052 15.8 0.2 1.1 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Protamine_P2 PF00841.14 CDI82047.1 - 1.7 9.2 7.6 3.6 8.1 4.1 1.9 1 1 1 2 2 2 0 Sperm histone P2 AMP-binding PF00501.23 CDI82048.1 - 6.7e-15 54.4 0.0 1.6e-14 53.1 0.0 1.6 1 1 0 1 1 1 1 AMP-binding enzyme DEAD PF00270.24 CDI82050.1 - 1.1e-24 86.7 0.3 2.6e-18 66.0 0.1 2.5 1 1 1 2 2 2 2 DEAD/DEAH box helicase CMS1 PF14617.1 CDI82050.1 - 0.0057 15.7 0.4 0.12 11.3 0.1 2.2 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DUF3530 PF12048.3 CDI82050.1 - 0.0091 15.0 6.8 0.041 12.8 1.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3530) AAA_22 PF13401.1 CDI82050.1 - 0.013 15.6 1.8 0.096 12.8 0.2 2.3 1 1 1 2 2 2 0 AAA domain SR-25 PF10500.4 CDI82050.1 - 0.025 14.0 8.3 0.041 13.3 5.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sigma70_ner PF04546.8 CDI82050.1 - 0.15 11.6 11.5 8.7 5.9 7.3 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Pox_RNA_Pol_19 PF05320.7 CDI82050.1 - 6.6 6.4 6.9 29 4.3 0.0 2.2 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF2946 PF11162.3 CDI82050.1 - 6.8 6.9 14.0 0.3 11.3 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) TRAP_alpha PF03896.11 CDI82050.1 - 7.2 5.5 7.4 13 4.7 5.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SprA-related PF12118.3 CDI82055.1 - 0.0014 17.9 23.1 0.0014 17.9 16.0 3.4 3 1 0 3 3 3 2 SprA-related family GN3L_Grn1 PF08701.6 CDI82055.1 - 0.012 15.4 3.7 0.012 15.4 2.5 3.5 3 0 0 3 3 3 0 GNL3L/Grn1 putative GTPase AAA_23 PF13476.1 CDI82055.1 - 0.042 14.1 0.3 0.042 14.1 0.2 3.4 3 1 0 3 3 3 0 AAA domain T2SE PF00437.15 CDI82057.1 - 1.2e-05 24.3 0.0 1.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein MobB PF03205.9 CDI82057.1 - 0.0012 18.5 3.3 0.27 10.9 0.0 2.7 3 0 0 3 3 3 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 CDI82057.1 - 0.0017 18.5 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CDI82057.1 - 0.087 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TrwB_AAD_bind PF10412.4 CDI82057.1 - 0.12 10.9 0.2 0.24 9.9 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.1 CDI82057.1 - 0.17 12.1 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 CDI82057.1 - 0.83 9.6 5.6 0.16 11.9 0.4 2.3 2 1 0 2 2 2 0 AAA ATPase domain AAA_9 PF12781.2 CDI82066.1 - 6.8e-87 290.0 0.3 1e-86 289.4 0.2 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 Dynein_heavy PF03028.10 CDI82066.1 - 1.2e-09 36.8 0.7 1.2e-09 36.8 0.5 2.3 2 1 1 3 3 3 1 Dynein heavy chain and region D6 of dynein motor DUF342 PF03961.8 CDI82066.1 - 0.48 8.7 3.3 0.75 8.1 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.7 CDI82066.1 - 5.3 5.9 10.6 32 3.4 7.0 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 LUC7 PF03194.10 CDI82070.1 - 4.3e-15 55.9 0.2 4.3e-15 55.9 0.1 3.4 1 1 2 3 3 3 1 LUC7 N_terminus DUF4080 PF13311.1 CDI82070.1 - 0.14 12.2 12.1 1.5 8.8 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) Lipid_DES PF08557.5 CDI82073.1 - 1.2e-12 46.8 0.1 2e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) SR-25 PF10500.4 CDI82073.1 - 0.00037 20.0 12.1 0.00037 20.0 8.4 2.5 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein MSA-2c PF12238.3 CDI82073.1 - 0.083 12.5 0.3 0.083 12.5 0.2 2.5 2 1 0 2 2 2 0 Merozoite surface antigen 2c DUF1980 PF09323.5 CDI82073.1 - 0.098 12.3 1.2 0.2 11.3 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF3449 PF11931.3 CDI82074.1 - 1.7e-16 60.3 0.1 1.8e-16 60.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) Med3 PF11593.3 CDI82075.1 - 4 6.5 6.9 4.5 6.4 4.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ubiq_cyt_C_chap PF03981.7 CDI82076.1 - 3.8e-06 26.8 0.0 8.6e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Maf_N PF08383.6 CDI82076.1 - 0.09 12.3 1.0 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 Maf N-terminal region SR-25 PF10500.4 CDI82076.1 - 1.8 7.9 22.5 4.7 6.6 0.3 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Di19_C PF14571.1 CDI82076.1 - 3.5 7.9 12.2 0.079 13.2 2.3 2.1 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal Gly-zipper_OmpA PF13436.1 CDI82076.1 - 7.4 6.2 12.0 7 6.3 0.0 3.2 2 1 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Ashwin PF15323.1 CDI82077.1 - 1.2 9.0 5.7 2.5 8.0 3.9 1.4 1 0 0 1 1 1 0 Developmental protein Anti-adapt_IraP PF10796.4 CDI82082.1 - 0.12 12.7 1.0 0.16 12.3 0.7 1.2 1 0 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein WD40 PF00400.27 CDI82083.1 - 0.0073 16.1 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat FAM60A PF15396.1 CDI82083.1 - 0.017 14.9 10.4 0.024 14.4 7.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A PPV_E1_N PF00524.13 CDI82083.1 - 0.021 15.0 4.9 0.021 15.0 3.4 3.0 3 1 0 3 3 2 0 E1 Protein, N terminal domain Herpes_UL87 PF03043.9 CDI82083.1 - 0.19 10.0 4.0 0.21 9.9 2.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family PAT1 PF09770.4 CDI82083.1 - 0.22 9.7 38.1 0.24 9.6 26.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.7 CDI82083.1 - 0.3 9.6 19.1 0.39 9.2 13.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) OmpH PF03938.9 CDI82083.1 - 1.4 8.8 39.1 0.13 12.2 24.1 1.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FUSC PF04632.7 CDI82083.1 - 1.9 6.8 14.4 2.3 6.5 10.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ebola_NP PF05505.7 CDI82083.1 - 4.9 5.1 23.1 6 4.7 16.0 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein DUF1777 PF08648.7 CDI82083.1 - 8.2 6.1 16.8 12 5.6 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF2146 PF10220.4 CDI82083.1 - 9.2 4.1 18.7 12 3.7 13.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Pkinase PF00069.20 CDI82085.1 - 5.7e-23 81.3 0.0 5.7e-23 81.3 0.0 3.6 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82085.1 - 1.8e-15 56.7 0.5 1.8e-15 56.7 0.4 3.6 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 CDI82086.1 - 9.7e-62 208.4 0.0 1.1e-61 208.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82086.1 - 9.5e-32 110.0 0.0 1.1e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI82086.1 - 2.3e-07 30.0 0.0 3.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 CDI82086.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 CDI82086.1 - 0.073 12.3 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 CDI82086.1 - 0.079 12.6 0.0 0.19 11.4 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family EF-hand_1 PF00036.27 CDI82090.1 - 2.8e-27 91.9 7.0 3.1e-07 29.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.1 CDI82090.1 - 3.8e-23 79.7 6.2 4.1e-05 22.7 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDI82090.1 - 3.2e-22 78.4 4.5 6.7e-10 38.9 0.2 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 CDI82090.1 - 2e-21 73.8 3.9 2.3e-05 23.8 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 CDI82090.1 - 2e-14 52.8 8.7 4.3e-05 23.0 0.2 3.7 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 CDI82090.1 - 1.5e-07 31.0 1.2 6.5e-05 22.6 0.0 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 CDI82090.1 - 0.00017 21.5 0.2 0.24 11.4 0.0 2.8 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Chorion_2 PF03964.10 CDI82091.1 - 0.023 15.2 3.9 0.048 14.2 2.7 1.5 1 0 0 1 1 1 0 Chorion family 2 RelB_N PF12910.2 CDI82091.1 - 0.18 11.1 0.0 29 4.1 0.0 2.6 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin stability system N-terminal WD40 PF00400.27 CDI82092.1 - 3.8e-12 45.6 19.9 0.00014 21.5 0.5 6.6 6 2 0 6 6 6 4 WD domain, G-beta repeat GRIM-19 PF06212.7 CDI82092.1 - 0.3 10.7 8.4 0.058 13.1 2.9 1.9 1 1 1 2 2 2 0 GRIM-19 protein Cut12 PF11500.3 CDI82092.1 - 6.3 6.4 15.0 13 5.4 10.4 1.5 1 0 0 1 1 1 0 Spindle pole body formation-associated protein ATG_C PF09333.6 CDI82094.1 - 0.0027 17.8 0.0 0.011 15.8 0.0 2.1 1 0 0 1 1 1 1 ATG C terminal domain Glyco_transf_22 PF03901.12 CDI82094.1 - 0.22 10.5 0.1 0.35 9.8 0.1 1.2 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family Chorein_N PF12624.2 CDI82094.1 - 0.42 10.1 0.0 3.7 7.1 0.0 2.3 2 0 0 2 2 2 0 N-terminal region of Chorein, a TM vesicle-mediated sorter HhH-GPD PF00730.20 CDI82095.1 - 8.1e-10 38.9 0.0 1.6e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 CDI82095.1 - 0.00019 20.9 0.3 0.13 12.0 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.1 CDI82095.1 - 0.0003 20.8 0.0 0.26 11.5 0.0 2.3 1 1 1 2 2 2 2 Helix-hairpin-helix domain HHH_2 PF12826.2 CDI82095.1 - 0.0034 17.2 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix motif Med15 PF09606.5 CDI82095.1 - 0.0075 14.5 73.0 0.0092 14.2 50.6 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI82095.1 - 0.057 11.6 63.1 0.071 11.3 43.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI82095.1 - 0.12 10.0 28.9 0.15 9.7 20.0 1.2 1 0 0 1 1 1 0 Ycf1 AvrE PF11725.3 CDI82095.1 - 2.7 4.8 35.4 3.3 4.6 24.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor RAP1 PF07218.6 CDI82095.1 - 7.8 4.4 11.2 11 3.8 7.8 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Lon_C PF05362.8 CDI82097.1 - 2.7e-07 30.1 0.1 4e-07 29.5 0.0 1.3 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain CytochromB561_N PF09786.4 CDI82098.1 - 4.4 5.6 12.1 4.6 5.5 8.4 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal KdpC PF02669.10 CDI82099.1 - 0.038 13.6 4.1 0.057 13.1 2.8 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain THP2 PF09432.5 CDI82099.1 - 0.26 11.1 4.5 0.36 10.6 3.1 1.3 1 0 0 1 1 1 0 Tho complex subunit THP2 AP_endonuc_2 PF01261.19 CDI82099.1 - 0.5 9.6 3.9 0.61 9.3 2.7 1.3 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Cytokin-bind PF09265.5 CDI82099.1 - 0.64 9.1 4.2 0.4 9.7 1.5 1.6 1 1 1 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding DUF342 PF03961.8 CDI82099.1 - 0.92 7.8 12.4 2.4 6.4 8.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.10 CDI82099.1 - 8.4 5.4 18.4 11 5.0 12.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pro-rich PF15240.1 CDI82100.1 - 6.9 6.7 30.4 9.5 6.2 21.1 1.3 1 0 0 1 1 1 0 Proline-rich CDK5_activator PF03261.10 CDI82101.1 - 0.022 14.1 14.3 0.025 13.9 9.9 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein TFIIA PF03153.8 CDI82101.1 - 0.028 14.3 27.3 0.033 14.0 18.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MRP-S31 PF15433.1 CDI82101.1 - 0.084 12.2 22.6 0.11 11.9 15.7 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 PAT1 PF09770.4 CDI82101.1 - 0.19 9.9 40.7 0.23 9.6 28.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ERK-JNK_inhib PF15002.1 CDI82101.1 - 1.7 7.9 27.0 0.034 13.5 10.5 2.1 2 0 0 2 2 2 0 ERK and JNK pathways, inhibitor G-7-MTase PF12803.2 CDI82101.1 - 2 7.4 9.0 3.4 6.7 6.2 1.3 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Hid1 PF12722.2 CDI82101.1 - 2.7 5.5 16.0 3.3 5.2 11.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Prog_receptor PF02161.10 CDI82101.1 - 6 5.5 19.1 0.21 10.3 8.6 1.7 1 1 1 2 2 2 0 Progesterone receptor CRAL_TRIO_2 PF13716.1 CDI82103.1 - 4.5e-06 26.6 0.0 7.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain IncA PF04156.9 CDI82103.1 - 0.00022 20.8 3.6 0.00022 20.8 2.5 2.2 2 0 0 2 2 2 1 IncA protein BUD22 PF09073.5 CDI82103.1 - 0.0005 19.2 3.3 0.0005 19.2 2.3 2.4 2 1 0 2 2 1 1 BUD22 Plasmodium_Vir PF05795.6 CDI82103.1 - 0.081 12.1 11.2 0.68 9.0 3.0 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein SID-1_RNA_chan PF13965.1 CDI82103.1 - 0.26 9.4 5.6 0.39 8.8 3.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.5 CDI82103.1 - 0.48 10.2 12.0 0.026 14.3 4.1 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Peptidase_M56 PF05569.6 CDI82103.1 - 0.87 8.5 3.1 1.8 7.4 2.1 1.6 1 0 0 1 1 1 0 BlaR1 peptidase M56 TFIIA PF03153.8 CDI82103.1 - 0.92 9.3 33.4 1.2 8.9 23.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Herpes_UL32 PF06070.6 CDI82103.1 - 2.1 6.6 18.2 2.5 6.4 12.6 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 SpaB_C PF14028.1 CDI82103.1 - 3.8 7.0 14.6 0.097 12.2 1.6 2.1 2 0 0 2 2 2 0 SpaB C-terminal domain DUF1510 PF07423.6 CDI82103.1 - 5.7 6.2 25.4 0.044 13.1 7.6 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1510) ELFV_dehydrog PF00208.16 CDI82109.1 - 4.9e-15 55.7 0.0 8.5e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 CDI82109.1 - 2.4e-11 41.8 0.0 3.4e-11 41.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 CDI82109.1 - 0.045 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain eRF1_2 PF03464.10 CDI82110.1 - 3e-42 144.0 0.0 7.1e-42 142.8 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 CDI82110.1 - 1.7e-36 124.8 0.5 3e-36 124.1 0.4 1.4 1 0 0 1 1 1 1 eRF1 domain 3 Ribosomal_L7Ae PF01248.21 CDI82110.1 - 0.058 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ssl1 PF04056.9 CDI82110.1 - 0.062 12.8 0.1 0.092 12.3 0.1 1.3 1 0 0 1 1 1 0 Ssl1-like Pkinase PF00069.20 CDI82111.1 - 1.4e-21 76.7 0.0 2.9e-21 75.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain EF-hand_7 PF13499.1 CDI82111.1 - 1.3e-17 63.7 1.5 6.1e-08 32.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDI82111.1 - 1.2e-16 58.6 0.5 0.00013 21.0 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 CDI82111.1 - 9.8e-16 56.1 0.5 7.6e-05 22.2 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 CDI82111.1 - 4.5e-11 42.1 1.7 0.00012 21.6 0.0 4.0 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 CDI82111.1 - 3.3e-07 29.3 5.6 0.00036 19.7 0.0 3.7 4 0 0 4 4 4 2 EF hand Pkinase_Tyr PF07714.12 CDI82111.1 - 5.2e-05 22.4 0.0 8.1e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SPARC_Ca_bdg PF10591.4 CDI82111.1 - 0.001 19.0 0.1 1.1 9.2 0.0 2.6 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 CDI82111.1 - 0.0023 17.8 0.1 0.23 11.3 0.0 3.5 4 0 0 4 4 4 1 EF-hand domain RNase_PH PF01138.16 CDI82112.1 - 1.4e-16 60.9 0.0 1.2e-15 57.9 0.0 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 tRNA_edit PF04073.10 CDI82115.1 - 2.6e-06 27.2 0.0 7.2e-05 22.6 0.0 2.0 1 1 1 2 2 2 2 Aminoacyl-tRNA editing domain DUF4349 PF14257.1 CDI82116.1 - 0.00026 20.3 3.2 0.00026 20.3 2.2 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4349) Acid_PPase PF12689.2 CDI82116.1 - 0.082 12.5 0.2 0.27 10.8 0.1 1.7 2 0 0 2 2 2 0 Acid Phosphatase IQ-like PF15157.1 CDI82116.1 - 0.14 12.3 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 IQ-like Pox_A_type_inc PF04508.7 CDI82116.1 - 4.4 7.3 5.4 22 5.1 0.2 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat HC2 PF07382.6 CDI82118.1 - 8.2e-06 25.8 2.9 8.9e-06 25.6 2.0 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 DUF424 PF04242.8 CDI82118.1 - 0.12 12.4 4.5 1.3 9.0 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF424) Nuc_rec_co-act PF08815.5 CDI82118.1 - 0.17 11.4 5.0 5.5 6.6 0.3 2.4 2 0 0 2 2 2 0 Nuclear receptor coactivator GRAB PF10375.4 CDI82118.1 - 0.6 9.9 25.9 65 3.4 0.1 8.2 4 4 5 9 9 9 0 GRIP-related Arf-binding domain Phostensin_N PF13916.1 CDI82120.1 - 0.8 9.7 17.5 0.079 12.9 2.2 2.6 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal PGA_cap PF09587.5 CDI82120.1 - 0.97 8.7 4.8 0.21 10.9 0.6 1.9 2 1 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap Med19 PF10278.4 CDI82120.1 - 6.3 6.4 16.2 3.8 7.1 7.2 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Claudin_2 PF13903.1 CDI82120.1 - 6.4 6.4 8.5 0.14 11.8 0.3 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction PAN_4 PF14295.1 CDI82121.1 - 6.3e-15 54.6 4.8 3.2e-07 29.9 0.2 2.6 2 0 0 2 2 2 2 PAN domain PAN_2 PF08276.6 CDI82121.1 - 0.00067 19.4 4.2 0.13 12.1 0.3 3.2 2 0 0 2 2 2 2 PAN-like domain FadA PF09403.5 CDI82122.1 - 7.1e-06 26.0 5.0 7.1e-06 26.0 3.5 3.0 2 1 0 2 2 2 1 Adhesion protein FadA Microvir_lysis PF04517.7 CDI82122.1 - 0.1 12.3 0.1 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Microvirus lysis protein (E), C terminus SAS4 PF15460.1 CDI82122.1 - 1.5 8.7 17.2 1.1 9.1 6.0 2.3 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 ToxN_toxin PF13958.1 CDI82122.1 - 3.9 7.1 15.5 2 8.0 8.7 1.8 2 0 0 2 2 2 0 Toxin ToxN, type III toxin-antitoxin system gag-asp_proteas PF13975.1 CDI82124.1 - 2.4e-10 40.0 0.1 6.1e-10 38.7 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 CDI82124.1 - 1e-08 35.5 0.0 2.6e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 CDI82124.1 - 5.6e-06 26.2 0.0 1.6e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 CDI82124.1 - 1.6e-05 24.8 0.0 3.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.21 CDI82124.1 - 0.00017 21.6 0.1 0.00035 20.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 CDI82124.1 - 0.00051 19.4 0.0 0.003 16.9 0.0 2.0 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease PF09668.5 CDI82124.1 - 0.023 14.2 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease DUF1758 PF05585.7 CDI82124.1 - 0.11 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative peptidase (DUF1758) DUF572 PF04502.8 CDI82126.1 - 0.16 11.1 12.3 0.17 11.0 8.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) LCD1 PF09798.4 CDI82126.1 - 1.2 7.0 6.8 1.4 6.8 4.7 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF2217 PF10265.4 CDI82126.1 - 3.6 6.2 8.2 4.5 5.9 5.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Hid1 PF12722.2 CDI82126.1 - 3.6 5.1 7.1 3.9 5.0 4.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein IncA PF04156.9 CDI82128.1 - 0.0062 16.1 19.9 0.0062 16.1 13.8 3.4 2 1 0 2 2 1 1 IncA protein DUF4175 PF13779.1 CDI82128.1 - 0.073 10.7 104.2 0.19 9.3 36.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) GAGA_bind PF06217.7 CDI82128.1 - 0.081 12.8 30.0 0.013 15.4 6.3 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family DUF4045 PF13254.1 CDI82128.1 - 0.15 11.3 30.3 0.12 11.6 6.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) CAF-1_p150 PF11600.3 CDI82128.1 - 0.64 9.3 45.1 0.033 13.5 9.9 2.1 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SprA-related PF12118.3 CDI82128.1 - 0.71 9.1 83.7 0.033 13.5 24.8 2.2 2 0 0 2 2 2 0 SprA-related family Herpes_UL87 PF03043.9 CDI82128.1 - 0.81 8.0 11.8 1.5 7.1 8.2 1.3 1 1 0 1 1 1 0 Herpesvirus UL87 family DDHD PF02862.12 CDI82128.1 - 0.82 9.4 39.3 0.3 10.8 9.7 2.1 2 0 0 2 2 2 0 DDHD domain Ycf1 PF05758.7 CDI82128.1 - 0.84 7.2 36.0 0.4 8.3 9.9 2.0 2 0 0 2 2 2 0 Ycf1 DUF3449 PF11931.3 CDI82128.1 - 1.1 8.7 37.8 0.13 11.7 8.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Spore_coat_CotO PF14153.1 CDI82128.1 - 1.5 8.2 54.0 0.35 10.2 15.1 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Caldesmon PF02029.10 CDI82128.1 - 1.7 6.9 34.6 1.3 7.3 9.6 2.1 2 0 0 2 2 2 0 Caldesmon FYDLN_acid PF09538.5 CDI82128.1 - 2 9.0 27.3 5.4 7.6 5.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Vfa1 PF08432.5 CDI82128.1 - 2.4 8.1 38.5 4.2 7.3 10.1 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Dynamin_N PF00350.18 CDI82128.1 - 2.4 7.9 17.0 2.3 7.9 3.6 2.5 2 0 0 2 2 2 0 Dynamin family Hom_end_hint PF05203.11 CDI82128.1 - 2.6 7.7 25.5 0.26 10.9 4.8 2.1 2 0 0 2 2 2 0 Hom_end-associated Hint Pal1 PF08316.6 CDI82128.1 - 2.7 8.4 17.9 0.89 9.9 3.5 2.3 2 0 0 2 2 2 0 Pal1 cell morphology protein Rot1 PF10681.4 CDI82128.1 - 3.9 6.7 19.4 0.061 12.6 3.8 2.4 2 0 0 2 2 2 0 Chaperone for protein-folding within the ER, fungal Peptidase_S64 PF08192.6 CDI82128.1 - 4.6 5.4 29.6 1.8 6.7 6.1 2.0 2 0 0 2 2 2 0 Peptidase family S64 DUF1510 PF07423.6 CDI82128.1 - 5 6.4 42.7 0.58 9.4 11.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) DDRGK PF09756.4 CDI82128.1 - 5.3 6.3 56.3 1.5 8.2 17.6 2.2 2 0 0 2 2 2 0 DDRGK domain PRP1_N PF06424.7 CDI82128.1 - 5.5 7.3 27.3 2.9 8.2 5.4 2.5 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal AUX_IAA PF02309.11 CDI82128.1 - 5.6 6.6 27.9 0.21 11.2 5.0 2.3 2 0 0 2 2 2 0 AUX/IAA family Peptidase_C6 PF00851.13 CDI82128.1 - 9.1 4.7 26.8 0.2 10.2 5.4 2.0 2 0 0 2 2 2 0 Helper component proteinase Pox_Ag35 PF03286.9 CDI82128.1 - 9.3 5.7 26.0 2.9 7.3 5.7 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Chlam_vir PF05475.6 CDI82129.1 - 0.37 9.8 2.3 0.64 9.0 1.0 1.7 2 0 0 2 2 2 0 Chlamydia virulence protein PGP3-D KR PF08659.5 CDI82131.1 - 4.6e-52 176.3 0.0 1.8e-51 174.4 0.0 2.0 1 1 0 1 1 1 1 KR domain PS-DH PF14765.1 CDI82131.1 - 9.8e-44 149.6 0.9 2.5e-43 148.3 0.6 1.7 1 1 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.20 CDI82131.1 - 7.2e-43 146.3 1.9 2.5e-42 144.6 0.1 2.6 2 1 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.20 CDI82131.1 - 4.8e-13 49.1 0.2 1e-12 48.1 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Acyl_transf_1 PF00698.16 CDI82131.1 - 0.00034 20.0 0.0 0.0006 19.2 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain 5_3_exonuc_N PF02739.11 CDI82134.1 - 5.6e-32 110.4 0.0 7.6e-30 103.5 0.0 2.1 2 0 0 2 2 2 2 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.15 CDI82134.1 - 1.6e-09 37.9 0.1 4.5e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Mus7 PF09462.5 CDI82134.1 - 0.049 12.4 0.4 0.06 12.1 0.3 1.1 1 0 0 1 1 1 0 Mus7/MMS22 family BAF1_ABF1 PF04684.8 CDI82134.1 - 5 5.8 7.0 7 5.3 4.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CPT PF07931.7 CDI82135.1 - 1.2 8.7 5.7 11 5.6 0.2 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ATP-gua_Ptrans PF00217.14 CDI82135.1 - 1.9 7.7 6.2 5.7 6.1 0.1 3.2 3 1 1 4 4 4 0 ATP:guanido phosphotransferase, C-terminal catalytic domain PAP_assoc PF03828.14 CDI82137.1 - 5e-09 35.9 0.0 1.2e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 CDI82137.1 - 0.0001 22.5 0.0 0.00076 19.7 0.0 2.3 2 0 0 2 2 2 1 Nucleotidyltransferase domain BAF1_ABF1 PF04684.8 CDI82137.1 - 2.8 6.7 13.4 1.1 8.0 0.1 3.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Patched PF02460.13 CDI82138.1 - 1.6e-91 307.4 22.6 3.4e-57 193.9 0.0 2.9 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.3 CDI82138.1 - 4.2e-32 110.7 8.8 4.2e-32 110.7 6.1 2.1 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation VIT1 PF01988.14 CDI82138.1 - 0.012 15.0 0.4 0.012 15.0 0.3 3.8 4 0 0 4 4 4 0 VIT family MORN PF02493.15 CDI82139.1 - 6.4e-19 66.4 17.4 3.1e-06 26.5 0.0 4.8 4 0 0 4 4 4 4 MORN repeat CRAL_TRIO_2 PF13716.1 CDI82140.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 CDI82140.1 - 0.013 14.9 0.1 0.05 13.1 0.0 1.8 1 1 0 1 1 1 0 CRAL/TRIO domain Lactamase_B PF00753.22 CDI82141.1 - 1.6e-22 80.1 0.3 2.1e-22 79.7 0.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.1 CDI82141.1 - 0.022 14.4 0.0 0.094 12.4 0.0 1.8 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.2 CDI82141.1 - 0.069 12.6 0.1 0.13 11.7 0.0 1.5 1 1 0 1 1 1 0 Beta-lactamase superfamily domain UPF0139 PF03669.8 CDI82142.1 - 5.5e-05 22.6 0.1 7e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Mito_carr PF00153.22 CDI82143.1 - 4e-55 183.5 12.2 5.8e-20 70.7 0.0 5.1 3 2 0 3 3 3 3 Mitochondrial carrier protein HCV_NS5a_1a PF08300.8 CDI82143.1 - 0.072 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a zinc finger domain DUF3249 PF11615.3 CDI82145.1 - 0.07 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3249) zf-CCCH PF00642.19 CDI82146.1 - 2.6e-09 36.5 17.4 0.00015 21.3 0.5 3.5 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3H1 PF10650.4 CDI82146.1 - 0.02 14.3 1.7 0.02 14.3 1.2 2.2 2 0 0 2 2 2 0 Putative zinc-finger domain HALZ PF02183.13 CDI82147.1 - 0.0078 15.9 3.9 0.0078 15.9 2.7 12.8 13 0 0 13 13 13 5 Homeobox associated leucine zipper Reo_sigmaC PF04582.7 CDI82147.1 - 0.32 10.1 50.3 0.012 14.8 1.4 6.0 4 3 3 7 7 7 0 Reovirus sigma C capsid protein Pkinase PF00069.20 CDI82149.1 - 5.9e-51 173.1 1.0 7.7e-36 123.5 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82149.1 - 1.4e-23 83.3 0.0 8.6e-22 77.4 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase EF-hand_7 PF13499.1 CDI82149.1 - 4.4e-16 58.7 1.1 1.5e-08 34.6 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 CDI82149.1 - 5.6e-16 56.5 2.7 0.002 17.2 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 CDI82149.1 - 2.1e-11 42.6 8.6 0.0075 16.0 0.0 5.0 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 CDI82149.1 - 4.6e-08 32.0 12.1 0.045 13.1 0.1 5.4 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 CDI82149.1 - 5.9e-08 32.2 5.8 0.13 11.8 0.0 4.7 5 0 0 5 5 5 3 EF-hand domain pair Kinase-like PF14531.1 CDI82149.1 - 6.1e-05 22.1 0.0 0.09 11.7 0.0 2.7 3 0 0 3 3 3 2 Kinase-like SAGA-Tad1 PF12767.2 CDI82149.1 - 0.072 12.7 38.9 0.23 11.0 9.4 4.7 4 0 0 4 4 4 0 Transcriptional regulator of RNA polII, SAGA, subunit LMBR1 PF04791.11 CDI82149.1 - 4.2 5.8 1.1 26 3.2 0.7 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein SET PF00856.23 CDI82150.1 - 5.2e-18 65.8 0.0 5.2e-18 65.8 0.0 10.8 9 3 0 9 9 9 1 SET domain Bromodomain PF00439.20 CDI82150.1 - 9.7e-09 35.0 0.0 2.2e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain PHD PF00628.24 CDI82150.1 - 6.2e-05 22.6 14.4 8.5e-05 22.1 1.6 8.9 8 1 1 9 9 9 3 PHD-finger FYRN PF05964.9 CDI82150.1 - 0.077 12.4 0.0 0.29 10.5 0.0 2.0 1 0 0 1 1 1 0 F/Y-rich N-terminus Frizzled PF01534.12 CDI82150.1 - 0.25 10.0 0.1 0.57 8.9 0.1 1.6 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region ABC_tran PF00005.22 CDI82151.1 - 1.2e-32 113.0 23.5 4.9e-15 56.0 0.0 5.0 4 1 0 4 4 3 3 ABC transporter AAA_21 PF13304.1 CDI82151.1 - 8.4e-29 101.4 0.0 2.3e-07 31.0 0.0 4.1 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 CDI82151.1 - 3.4e-19 68.9 8.3 1.6e-08 34.0 3.4 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDI82151.1 - 9.1e-11 41.1 0.4 0.00066 19.1 0.0 3.2 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 CDI82151.1 - 1.3e-08 34.3 0.0 0.15 11.0 0.0 4.1 4 0 0 4 4 4 2 AAA ATPase domain AAA_25 PF13481.1 CDI82151.1 - 6.9e-08 32.1 1.4 0.0036 16.7 0.2 3.0 2 1 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CDI82151.1 - 1.1e-07 32.6 0.0 0.0011 19.7 0.2 2.6 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 CDI82151.1 - 1.6e-07 30.5 5.1 0.00028 19.8 0.1 3.7 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_23 PF13476.1 CDI82151.1 - 4.9e-07 30.2 1.3 0.00026 21.3 0.0 6.1 3 2 1 4 4 2 2 AAA domain PduV-EutP PF10662.4 CDI82151.1 - 1.1e-06 28.2 3.4 0.0021 17.5 0.0 2.5 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 CDI82151.1 - 1.6e-06 27.9 0.4 0.013 15.2 0.1 2.5 2 0 0 2 2 2 2 NTPase MobB PF03205.9 CDI82151.1 - 1.7e-06 27.8 0.0 0.022 14.4 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 CDI82151.1 - 2.5e-06 27.4 0.0 0.076 12.9 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_19 PF13245.1 CDI82151.1 - 6e-06 25.9 0.1 0.002 17.8 0.0 5.3 5 0 0 5 5 3 2 Part of AAA domain FtsK_SpoIIIE PF01580.13 CDI82151.1 - 6.9e-06 25.6 3.8 0.011 15.2 0.1 3.0 3 0 0 3 3 3 2 FtsK/SpoIIIE family AAA_18 PF13238.1 CDI82151.1 - 2e-05 24.8 0.0 0.048 13.9 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 CDI82151.1 - 2.6e-05 24.4 5.0 0.085 13.0 0.0 3.8 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) Miro PF08477.8 CDI82151.1 - 4.4e-05 23.9 11.4 0.019 15.4 0.0 3.5 3 1 0 3 3 2 2 Miro-like protein AAA_14 PF13173.1 CDI82151.1 - 5.7e-05 23.0 0.3 0.25 11.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain UPF0079 PF02367.12 CDI82151.1 - 8.6e-05 22.1 1.1 0.23 11.1 0.1 2.6 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 CDI82151.1 - 8.9e-05 22.6 0.2 0.37 10.9 0.0 2.6 2 0 0 2 2 2 2 RNA helicase DUF258 PF03193.11 CDI82151.1 - 0.00015 20.9 10.5 0.0047 16.1 0.2 2.9 3 0 0 3 3 2 2 Protein of unknown function, DUF258 Arf PF00025.16 CDI82151.1 - 0.0002 20.6 0.4 0.72 9.0 0.1 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family ATP-synt_ab PF00006.20 CDI82151.1 - 0.0002 20.9 1.6 0.0067 15.9 0.1 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.1 CDI82151.1 - 0.00024 21.2 20.3 0.0047 17.0 0.0 5.4 4 2 0 4 4 4 1 AAA domain Pox_A32 PF04665.7 CDI82151.1 - 0.00043 19.6 0.2 0.79 8.9 0.0 2.8 3 0 0 3 3 3 2 Poxvirus A32 protein cobW PF02492.14 CDI82151.1 - 0.00053 19.4 0.1 0.024 14.0 0.0 2.9 3 0 0 3 3 2 2 CobW/HypB/UreG, nucleotide-binding domain Arch_ATPase PF01637.13 CDI82151.1 - 0.00055 19.7 0.1 0.8 9.3 0.0 2.3 2 0 0 2 2 2 2 Archaeal ATPase AAA_5 PF07728.9 CDI82151.1 - 0.00056 19.6 1.0 2.2 8.0 0.1 3.6 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) SRP54 PF00448.17 CDI82151.1 - 0.00061 19.2 1.3 0.014 14.8 0.1 4.5 5 0 0 5 5 2 2 SRP54-type protein, GTPase domain NACHT PF05729.7 CDI82151.1 - 0.001 18.7 0.1 0.001 18.7 0.0 4.9 4 2 1 5 5 3 1 NACHT domain G-alpha PF00503.15 CDI82151.1 - 0.0012 17.6 13.7 0.0012 17.6 9.5 4.1 3 1 0 4 4 2 1 G-protein alpha subunit ATP_bind_1 PF03029.12 CDI82151.1 - 0.0013 18.2 0.1 0.44 10.0 0.0 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 CDI82151.1 - 0.0014 18.0 9.9 0.12 11.8 0.0 3.3 3 1 0 3 3 2 2 Elongation factor Tu GTP binding domain AAA_28 PF13521.1 CDI82151.1 - 0.0014 18.5 0.2 0.0014 18.5 0.1 6.2 6 1 0 6 6 3 1 AAA domain FeoB_N PF02421.13 CDI82151.1 - 0.0021 17.3 0.5 0.91 8.7 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B IstB_IS21 PF01695.12 CDI82151.1 - 0.0037 16.7 2.3 0.027 13.8 0.2 3.4 4 0 0 4 4 2 2 IstB-like ATP binding protein SR-25 PF10500.4 CDI82151.1 - 0.0046 16.4 15.8 0.0046 16.4 10.9 5.6 5 1 0 6 6 3 2 Nuclear RNA-splicing-associated protein SRPRB PF09439.5 CDI82151.1 - 0.007 15.5 0.2 0.8 8.8 0.0 2.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit SbcCD_C PF13558.1 CDI82151.1 - 0.013 15.4 0.1 0.013 15.4 0.1 6.5 5 2 1 6 6 4 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.1 CDI82151.1 - 0.037 13.9 0.1 0.037 13.9 0.0 5.8 3 2 2 5 5 4 0 AAA domain AAA_24 PF13479.1 CDI82151.1 - 0.069 12.7 0.0 0.069 12.7 0.0 4.1 4 1 0 4 4 2 0 AAA domain AAA_10 PF12846.2 CDI82151.1 - 0.075 12.4 0.0 0.075 12.4 0.0 3.5 3 1 1 4 4 2 0 AAA-like domain ArgK PF03308.11 CDI82151.1 - 0.18 10.5 10.5 0.83 8.3 0.1 3.9 3 1 1 4 4 4 0 ArgK protein Septin PF00735.13 CDI82151.1 - 0.32 9.9 0.0 0.14 11.1 0.2 3.8 4 0 0 4 4 2 0 Septin NB-ARC PF00931.17 CDI82151.1 - 1 8.1 11.1 1.3 7.7 0.0 3.3 3 1 0 3 3 2 0 NB-ARC domain PRK PF00485.13 CDI82151.1 - 6.5 6.2 7.7 12 5.3 0.0 2.8 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family LSM14 PF12701.2 CDI82153.1 - 3.8e-16 58.6 0.0 8.3e-16 57.5 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.5 CDI82153.1 - 4.1e-06 27.2 16.0 0.0009 19.7 4.8 2.4 1 1 1 2 2 2 2 FDF domain Rcd1 PF04078.8 CDI82154.1 - 1.2e-62 211.2 0.0 1.3e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like OS-D PF03392.8 CDI82154.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D FliP PF00813.15 CDI82155.1 - 0.015 15.0 1.6 0.031 13.9 1.1 1.5 1 0 0 1 1 1 0 FliP family GHBP PF12772.2 CDI82155.1 - 0.26 10.6 7.5 0.54 9.6 5.2 1.5 1 0 0 1 1 1 0 Growth hormone receptor binding YicC_N PF03755.8 CDI82155.1 - 0.63 9.9 6.6 0.21 11.5 2.2 2.0 2 0 0 2 2 2 0 YicC-like family, N-terminal region DUF2393 PF09624.5 CDI82155.1 - 2.9 7.4 5.0 0.28 10.7 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) RskA PF10099.4 CDI82156.1 - 0.019 14.6 15.6 0.064 12.9 2.2 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA COX7B PF05392.6 CDI82156.1 - 0.038 13.5 0.7 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB EST1 PF10374.4 CDI82156.1 - 0.32 10.9 4.8 5.4 7.0 0.1 2.2 2 0 0 2 2 2 0 Telomerase activating protein Est1 Med15 PF09606.5 CDI82156.1 - 0.42 8.7 26.3 0.16 10.1 5.2 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal RAB3GAP2_N PF14655.1 CDI82156.1 - 0.42 9.5 7.6 0.61 9.0 0.3 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus AAA_22 PF13401.1 CDI82156.1 - 0.6 10.2 2.7 0.36 10.9 0.5 1.6 2 0 0 2 2 2 0 AAA domain Adeno_PIX PF03955.9 CDI82156.1 - 0.75 10.3 7.6 2.2 8.8 3.0 2.3 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) DUF2721 PF11026.3 CDI82156.1 - 2.7 7.6 6.7 5.9 6.5 0.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) DUF1049 PF06305.6 CDI82156.1 - 3.7 7.0 12.1 0.93 9.0 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1049) Chorion_2 PF03964.10 CDI82156.1 - 6 7.4 11.2 3 8.4 3.7 2.4 2 0 0 2 2 2 0 Chorion family 2 NHL PF01436.16 CDI82160.1 - 4.6e-17 61.0 0.1 8.2e-06 25.5 0.0 4.9 4 1 1 5 5 5 4 NHL repeat SGL PF08450.7 CDI82160.1 - 1.7e-10 40.7 0.0 9.6e-06 25.1 0.0 3.0 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region Lactonase PF10282.4 CDI82160.1 - 2e-05 23.8 0.0 4.5e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.15 CDI82160.1 - 0.00018 21.4 0.0 0.28 11.2 0.0 2.7 2 1 1 3 3 3 2 Arylesterase Str_synth PF03088.11 CDI82160.1 - 0.0013 18.7 0.0 0.081 12.9 0.0 2.7 2 1 1 3 3 3 1 Strictosidine synthase PQQ PF01011.16 CDI82160.1 - 0.026 14.0 0.9 1.5 8.4 0.0 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat Lustrin_cystein PF14625.1 CDI82160.1 - 1.2 9.2 30.1 0.79 9.8 1.8 4.4 2 2 2 4 4 4 0 Lustrin, cysteine-rich repeated domain Glyco_hydro_35 PF01301.14 CDI82161.1 - 2.1e-07 30.6 0.2 3.1e-05 23.4 0.0 2.6 3 0 0 3 3 3 2 Glycosyl hydrolases family 35 Spt20 PF12090.3 CDI82161.1 - 0.0011 18.3 0.1 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Spt20 family FimP PF09766.4 CDI82161.1 - 0.02 13.9 4.5 0.024 13.7 3.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein Pex14_N PF04695.8 CDI82161.1 - 4 7.5 10.0 0.3 11.1 2.0 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Helicase_RecD PF05127.9 CDI82164.1 - 3.1e-42 144.2 0.6 2.2e-40 138.1 0.0 2.7 2 1 0 2 2 2 1 Helicase DUF1726 PF08351.6 CDI82164.1 - 7.1e-05 22.4 0.0 0.00017 21.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) CbiM PF01891.11 CDI82164.1 - 0.0021 17.7 1.5 0.0029 17.2 1.0 1.1 1 0 0 1 1 1 1 Cobalt uptake substrate-specific transmembrane region FeoA PF04023.9 CDI82164.1 - 0.038 13.9 1.3 4.9 7.1 0.1 3.1 2 1 0 2 2 2 0 FeoA domain WBP-1 PF11669.3 CDI82164.1 - 2.1 8.4 7.1 3.4 7.7 0.0 2.3 1 1 1 2 2 2 0 WW domain-binding protein 1 ABC2_membrane PF01061.19 CDI82166.1 - 0.25 10.4 5.5 4.3 6.4 0.2 3.1 3 0 0 3 3 3 0 ABC-2 type transporter Ycf1 PF05758.7 CDI82169.1 - 0.12 10.0 0.3 0.15 9.7 0.2 1.1 1 0 0 1 1 1 0 Ycf1 Neur_chan_memb PF02932.11 CDI82169.1 - 0.35 10.7 2.6 0.51 10.1 0.2 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EF1G PF00647.14 CDI82175.1 - 3.2e-28 97.5 0.2 6e-28 96.6 0.2 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 CDI82175.1 - 3.4e-12 46.1 0.2 2.6e-11 43.3 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CDI82175.1 - 9.2e-08 31.8 0.1 2.4e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CDI82175.1 - 6.4e-07 29.7 0.7 2e-06 28.1 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CDI82175.1 - 0.00051 20.1 0.0 0.0018 18.3 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CDI82175.1 - 0.014 15.6 0.0 0.032 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain SR-25 PF10500.4 CDI82175.1 - 0.047 13.1 7.2 0.08 12.4 5.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Nse4_C PF08743.5 CDI82175.1 - 0.05 13.6 0.3 0.15 12.0 0.2 1.8 1 0 0 1 1 1 0 Nse4 C-terminal FAM217 PF15344.1 CDI82175.1 - 2.1 7.8 10.8 3.4 7.1 7.5 1.3 1 0 0 1 1 1 0 FAM217 family TetR_C_3 PF08362.6 CDI82177.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 YcdC-like protein, C-terminal region Kri1 PF05178.7 CDI82179.1 - 2.8e-17 62.8 14.0 2.8e-17 62.8 9.7 3.4 1 1 1 2 2 2 1 KRI1-like family PEX11 PF05648.9 CDI82179.1 - 4 6.6 9.0 0.27 10.4 0.4 2.2 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Shadoo PF14999.1 CDI82187.1 - 0.42 10.4 13.8 0.23 11.3 1.6 2.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective FAM104 PF15434.1 CDI82187.1 - 0.44 10.7 8.6 0.71 10.0 6.0 1.3 1 0 0 1 1 1 0 Family 104 AvrE PF11725.3 CDI82187.1 - 1.1 6.1 22.4 1.3 5.9 15.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor DUF966 PF06136.8 CDI82187.1 - 7.5 5.8 18.1 8.6 5.6 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) PLRV_ORF5 PF01690.12 CDI82187.1 - 8.2 5.4 17.9 9.2 5.2 12.4 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF3682 PF12446.3 CDI82187.1 - 8.4 6.6 38.4 0.16 12.2 8.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3682) EXOSC1 PF10447.4 CDI82192.1 - 2.3e-10 40.2 0.0 3.3e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 S1-P1_nuclease PF02265.11 CDI82194.1 - 5.3e-17 62.2 0.0 9.4e-17 61.4 0.0 1.4 1 1 0 1 1 1 1 S1/P1 Nuclease DUF3605 PF12239.3 CDI82194.1 - 0.00099 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) TFIIA PF03153.8 CDI82195.1 - 0.3 10.9 61.5 0.66 9.8 11.7 3.4 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit AAR2 PF05282.6 CDI82195.1 - 2.9 6.7 11.5 1.3 7.9 4.8 2.2 2 0 0 2 2 2 0 AAR2 protein YABBY PF04690.8 CDI82196.1 - 2.7 8.2 21.6 0.078 13.2 1.0 3.3 3 0 0 3 3 3 0 YABBY protein Pyr_redox_2 PF07992.9 CDI82197.1 - 0.0017 18.2 0.0 0.048 13.5 0.0 3.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UPF0564 PF10595.4 CDI82197.1 - 0.0029 16.5 23.6 0.0029 16.5 16.3 3.7 3 1 0 3 3 3 2 Uncharacterised protein family UPF0564 N6_N4_Mtase PF01555.13 CDI82197.1 - 0.048 13.1 0.0 2.1 7.8 0.0 3.2 2 1 0 2 2 2 0 DNA methylase SOBP PF15279.1 CDI82197.1 - 0.073 13.4 43.7 1.3 9.3 1.0 3.3 3 0 0 3 3 3 0 Sine oculis-binding protein NAD_binding_8 PF13450.1 CDI82197.1 - 0.12 12.4 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain AvrE PF11725.3 CDI82197.1 - 0.41 7.6 47.3 0.12 9.3 0.1 2.3 2 0 0 2 2 2 0 Pathogenicity factor Plasmodium_Vir PF05795.6 CDI82197.1 - 2.1 7.4 11.1 60 2.6 0.0 3.2 2 1 1 3 3 3 0 Plasmodium vivax Vir protein Cnd1 PF12717.2 CDI82200.1 - 8.8e-19 68.0 10.2 6.2e-10 39.2 0.2 4.7 4 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Ycf1 PF05758.7 CDI82200.1 - 2.3e-05 22.3 54.2 8.4e-05 20.5 5.1 4.2 4 0 0 4 4 4 3 Ycf1 SAGA-Tad1 PF12767.2 CDI82200.1 - 0.0026 17.4 10.7 0.0026 17.4 7.5 5.8 5 1 0 5 5 5 2 Transcriptional regulator of RNA polII, SAGA, subunit Neur_chan_memb PF02932.11 CDI82200.1 - 0.14 12.0 61.8 0.053 13.3 6.4 5.8 6 0 0 6 6 6 0 Neurotransmitter-gated ion-channel transmembrane region Cohesin_HEAT PF12765.2 CDI82200.1 - 0.23 11.4 5.5 0.31 11.0 0.8 3.2 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Colipase-like PF15083.1 CDI82208.1 - 0.14 12.1 0.8 0.21 11.5 0.6 1.2 1 0 0 1 1 1 0 Colipase-like DUF4175 PF13779.1 CDI82211.1 - 0.0017 16.1 0.8 0.0017 16.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Nop53 PF07767.6 CDI82211.1 - 0.0098 14.9 0.6 0.011 14.6 0.4 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) MFS_1 PF07690.11 CDI82211.1 - 0.015 14.0 0.2 0.016 13.9 0.1 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Med15 PF09606.5 CDI82211.1 - 0.032 12.4 9.2 0.033 12.4 6.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Cytochrom_B_N PF00033.14 CDI82211.1 - 0.049 12.9 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB DUF1282 PF06930.7 CDI82211.1 - 0.081 12.5 0.7 0.12 11.9 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) Baculo_helicase PF04735.7 CDI82211.1 - 0.11 9.8 0.2 0.12 9.7 0.1 1.0 1 0 0 1 1 1 0 Baculovirus DNA helicase RAB3GAP2_N PF14655.1 CDI82211.1 - 0.25 10.2 2.4 0.33 9.8 1.7 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Spt20 PF12090.3 CDI82211.1 - 0.43 9.8 2.6 0.54 9.5 1.8 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.4 CDI82211.1 - 0.78 7.9 3.3 0.96 7.6 2.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2489 PF10675.4 CDI82211.1 - 1 9.0 7.7 1.5 8.5 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) TSA PF03249.8 CDI82211.1 - 1.6 7.1 9.0 1.7 7.0 6.2 1.1 1 0 0 1 1 1 0 Type specific antigen DivIC PF04977.10 CDI82211.1 - 2.1 7.9 8.7 3 7.3 6.0 1.2 1 0 0 1 1 1 0 Septum formation initiator Androgen_recep PF02166.11 CDI82211.1 - 4.9 5.9 7.3 6 5.6 5.1 1.1 1 0 0 1 1 1 0 Androgen receptor PHD_3 PF13922.1 CDI82211.1 - 7.3 6.9 10.4 11 6.2 7.2 1.4 1 1 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx SHS2_Rpb7-N PF03876.12 CDI82212.1 - 4e-13 49.2 0.0 5.6e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 NUC153 PF08159.7 CDI82213.1 - 0.0072 15.8 0.4 0.073 12.6 0.1 2.4 2 0 0 2 2 2 1 NUC153 domain SR-25 PF10500.4 CDI82214.1 - 0.009 15.5 9.7 0.014 14.9 6.7 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 CDI82214.1 - 0.19 9.9 4.7 0.2 9.9 3.2 1.1 1 0 0 1 1 1 0 Transmembrane protein CAF-1_p150 PF11600.3 CDI82214.1 - 4.7 6.5 6.8 6.6 6.0 4.7 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AF-4 PF05110.8 CDI82214.1 - 6.2 4.5 14.2 8.6 4.0 9.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein UPF0560 PF10577.4 CDI82222.1 - 0.00052 18.4 4.9 0.00089 17.6 3.4 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 DUF2749 PF10907.3 CDI82222.1 - 0.22 11.4 4.6 18 5.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Med3 PF11593.3 CDI82222.1 - 7.7 5.6 13.5 2.9 7.0 6.2 1.9 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal HAT PF02184.11 CDI82223.1 - 0.00023 20.8 2.4 0.24 11.1 0.0 3.4 3 0 0 3 3 3 2 HAT (Half-A-TPR) repeat TPR_14 PF13428.1 CDI82223.1 - 0.0005 20.4 4.5 2.6 8.9 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDI82223.1 - 0.011 16.3 1.8 0.011 16.3 1.2 1.8 2 1 0 2 2 2 0 Tetratricopeptide repeat Sec2p PF06428.6 CDI82232.1 - 0.33 10.8 24.2 0.071 12.9 6.3 2.8 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p TMF_TATA_bd PF12325.3 CDI82232.1 - 0.45 10.2 20.6 0.084 12.6 6.0 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Rho_Binding PF08912.6 CDI82232.1 - 0.73 10.1 15.3 2.5 8.4 1.7 3.0 3 0 0 3 3 3 0 Rho Binding Bacillus_HBL PF05791.6 CDI82232.1 - 0.95 8.8 10.7 2.1 7.6 2.1 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) MscS_porin PF12795.2 CDI82232.1 - 1.1 8.4 46.0 0.3 10.3 10.8 2.5 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain ATG16 PF08614.6 CDI82232.1 - 2.6 7.8 32.8 8.5 6.1 20.6 2.7 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Sec8_exocyst PF04048.9 CDI82232.1 - 3.5 7.2 13.4 0.55 9.8 1.9 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain V_ATPase_I PF01496.14 CDI82232.1 - 6.5 4.4 20.7 0.92 7.2 5.8 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Reo_sigmaC PF04582.7 CDI82233.1 - 2.9 6.9 11.3 0.21 10.7 0.2 3.1 1 1 1 3 3 3 0 Reovirus sigma C capsid protein SF-assemblin PF06705.6 CDI82234.1 - 2.1e-23 82.7 8.0 1e-21 77.2 5.4 2.0 1 1 1 2 2 2 2 SF-assemblin/beta giardin Apolipoprotein PF01442.13 CDI82234.1 - 0.019 14.4 10.3 0.32 10.4 0.2 2.6 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF3829 PF12889.2 CDI82234.1 - 0.077 12.1 1.1 0.1 11.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) ADIP PF11559.3 CDI82234.1 - 0.24 11.2 4.6 0.51 10.2 3.2 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Mst1_SARAH PF11629.3 CDI82234.1 - 0.75 9.6 6.8 3.8 7.4 0.2 3.8 3 1 1 4 4 4 0 C terminal SARAH domain of Mst1 FadA PF09403.5 CDI82234.1 - 1.2 9.1 5.5 1.8 8.5 3.1 1.8 1 1 0 1 1 1 0 Adhesion protein FadA Uds1 PF15456.1 CDI82234.1 - 1.4 8.8 8.9 14 5.6 4.1 2.9 1 1 1 2 2 2 0 Up-regulated During Septation Mnd1 PF03962.10 CDI82234.1 - 5.4 6.6 7.7 5.8 6.5 2.0 2.3 1 1 1 2 2 2 0 Mnd1 family DUF4404 PF14357.1 CDI82234.1 - 6.5 7.2 7.6 34 4.9 0.1 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) zf-C2H2 PF00096.21 CDI82235.1 - 1.2e-05 25.3 0.4 2.3e-05 24.4 0.2 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type XPA_N PF01286.13 CDI82235.1 - 0.0028 17.2 0.1 0.005 16.4 0.1 1.3 1 0 0 1 1 1 1 XPA protein N-terminal Prefoldin_2 PF01920.15 CDI82235.1 - 0.0041 16.8 5.7 0.0041 16.8 4.0 3.3 3 1 0 3 3 3 1 Prefoldin subunit zf-C2H2_4 PF13894.1 CDI82235.1 - 0.012 15.9 0.2 0.027 14.7 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Tweety PF04906.8 CDI82235.1 - 0.58 8.5 7.0 3.4 5.9 1.2 2.3 2 0 0 2 2 2 0 Tweety MADF_DNA_bdg PF10545.4 CDI82235.1 - 1.2 9.4 3.9 0.37 10.9 0.3 2.1 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like zf-CCHC PF00098.18 CDI82237.1 - 0.00063 19.5 3.3 0.0014 18.4 2.3 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 CDI82237.1 - 0.067 12.8 0.5 0.1 12.2 0.4 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.1 CDI82237.1 - 0.11 12.0 5.5 0.42 10.1 3.8 2.0 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Pkinase PF00069.20 CDI82240.1 - 0.025 13.7 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain HAD_2 PF13419.1 CDI82241.1 - 0.037 14.2 0.2 5 7.3 0.1 2.4 1 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase MTBP_C PF14920.1 CDI82242.1 - 0.018 14.5 0.2 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 MDM2-binding LRR_6 PF13516.1 CDI82242.1 - 0.029 14.3 0.0 4.4 7.6 0.0 2.7 2 0 0 2 2 2 0 Leucine Rich repeat HOOK PF05622.7 CDI82243.1 - 0.33 8.6 0.0 0.33 8.6 0.0 3.8 2 1 1 3 3 3 0 HOOK protein DUF948 PF06103.6 CDI82243.1 - 0.94 9.3 0.0 0.94 9.3 0.0 6.3 4 2 3 7 7 7 0 Bacterial protein of unknown function (DUF948) Dynein_heavy PF03028.10 CDI82246.1 - 8.3e-25 86.9 0.0 1e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Ribosomal_60s PF00428.14 CDI82246.1 - 0.018 15.4 10.9 0.018 15.4 7.5 3.3 3 1 0 3 3 3 0 60s Acidic ribosomal protein DUF1501 PF07394.7 CDI82246.1 - 0.25 10.1 2.9 0.35 9.6 2.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1501) MelC1 PF06236.6 CDI82246.1 - 4 7.4 14.0 3.8 7.5 6.5 2.4 2 0 0 2 2 2 0 Tyrosinase co-factor MelC1 DUF1180 PF06679.7 CDI82246.1 - 5.6 6.8 9.2 1.7 8.5 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF3337 PF11816.3 CDI82247.1 - 0.015 14.7 1.2 0.016 14.6 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) MelC1 PF06236.6 CDI82247.1 - 0.19 11.7 1.7 0.26 11.2 1.2 1.2 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 PGA2 PF07543.7 CDI82247.1 - 0.22 11.3 9.4 0.27 11.0 6.5 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 Suf PF05843.9 CDI82247.1 - 0.63 9.7 10.6 0.66 9.6 7.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.3 CDI82247.1 - 0.77 9.0 8.4 0.95 8.7 5.8 1.3 1 0 0 1 1 1 0 Spt20 family SprA-related PF12118.3 CDI82247.1 - 0.99 8.6 21.2 1.1 8.5 14.7 1.1 1 0 0 1 1 1 0 SprA-related family Pilin PF00114.14 CDI82249.1 - 0.03 15.0 7.4 0.037 14.7 5.1 1.2 1 0 0 1 1 1 0 Pilin (bacterial filament) CDK5_activator PF03261.10 CDI82249.1 - 0.15 11.3 7.7 0.15 11.3 5.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Med15 PF09606.5 CDI82249.1 - 0.17 10.0 33.1 0.18 9.9 23.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI82249.1 - 0.4 10.3 9.4 0.4 10.3 6.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Serinc PF03348.10 CDI82249.1 - 0.47 9.1 6.0 0.5 9.0 4.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.17 CDI82249.1 - 0.95 8.4 4.6 0.98 8.3 3.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Herpes_UL87 PF03043.9 CDI82249.1 - 2 6.7 8.8 2 6.6 6.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family PAT1 PF09770.4 CDI82249.1 - 2.8 6.0 24.5 3 5.9 17.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3275 PF11679.3 CDI82249.1 - 5.9 6.4 17.5 22 4.5 11.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) DUF4557 PF15101.1 CDI82249.1 - 6.2 6.5 24.4 3.2 7.5 15.3 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4557) TFIIA PF03153.8 CDI82249.1 - 6.6 6.5 26.5 8.1 6.2 18.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.14 CDI82254.1 - 1.9e-06 28.1 28.5 0.0026 18.0 6.2 2.3 2 0 0 2 2 2 2 60s Acidic ribosomal protein XG_FTase PF03254.8 CDI82254.1 - 0.0074 14.8 0.0 0.0099 14.4 0.0 1.1 1 0 0 1 1 1 1 Xyloglucan fucosyltransferase DUF3138 PF11336.3 CDI82254.1 - 0.25 9.4 21.8 0.0058 14.8 4.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) DUF3597 PF12200.3 CDI82254.1 - 3.5 8.0 11.3 7.6 6.9 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Sugar_tr PF00083.19 CDI82256.1 - 0.11 11.0 2.1 0.16 10.4 1.5 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter MFS_1 PF07690.11 CDI82256.1 - 0.41 9.3 8.9 0.7 8.5 6.2 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily cNMP_binding PF00027.24 CDI82258.1 - 6.2e-23 80.4 0.0 4.3e-08 32.8 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase PF00069.20 CDI82258.1 - 3.4e-09 36.2 0.0 6.1e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Cupin_3 PF05899.7 CDI82258.1 - 0.021 14.1 0.0 9.5 5.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Cupin_2 PF07883.6 CDI82258.1 - 0.083 12.4 1.1 23 4.5 0.1 3.3 3 1 0 3 3 3 0 Cupin domain Pkinase_Tyr PF07714.12 CDI82258.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase SR-25 PF10500.4 CDI82258.1 - 6.9 6.0 11.0 9.9 5.5 1.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.4 CDI82261.1 - 2e-05 24.2 17.4 2e-05 24.2 12.1 5.3 3 2 1 4 4 4 1 Nuclear RNA-splicing-associated protein YjgP_YjgQ PF03739.9 CDI82261.1 - 1.7 7.2 11.7 2.9 6.5 8.1 1.3 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family PAT1 PF09770.4 CDI82261.1 - 6.6 4.8 76.7 1.6 6.8 9.9 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF2065 PF09838.4 CDI82273.1 - 0.018 14.7 0.0 3.2 7.5 0.0 3.0 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2065) DUF1470 PF07336.6 CDI82274.1 - 0.068 13.5 7.0 0.12 12.6 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1470) SR-25 PF10500.4 CDI82274.1 - 5.2 6.4 12.1 9.8 5.5 8.4 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Aminotran_1_2 PF00155.16 CDI82275.1 - 2.6e-37 128.6 0.0 3.3e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 CDI82275.1 - 0.00011 20.5 0.0 0.00018 19.9 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.15 CDI82275.1 - 0.00017 20.2 0.0 0.00086 17.9 0.0 1.8 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.12 CDI82275.1 - 0.0016 17.5 1.9 0.017 14.1 1.3 2.2 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CDI82275.1 - 0.0028 16.8 0.1 0.0037 16.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase LUC7 PF03194.10 CDI82277.1 - 0.022 14.3 0.0 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 LUC7 N_terminus Peptidase_S64 PF08192.6 CDI82278.1 - 2.3 6.4 12.1 2.6 6.2 8.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.2 CDI82278.1 - 9.1 3.8 5.8 10 3.6 4.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HSP70 PF00012.15 CDI82279.1 - 5.8e-34 116.9 0.0 3.7e-17 61.4 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 CDI82279.1 - 0.0037 15.8 0.3 0.16 10.5 0.0 2.0 2 0 0 2 2 2 2 MreB/Mbl protein Argos PF11581.3 CDI82279.1 - 0.15 12.0 0.4 0.58 10.1 0.0 2.1 2 1 1 3 3 3 0 Antagonist of EGFR signalling, Argos Carb_anhydrase PF00194.16 CDI82281.1 - 2.5e-16 59.4 2.1 3.8e-08 32.6 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic-type carbonic anhydrase GOLD_2 PF13897.1 CDI82281.1 - 0.79 9.9 3.0 2.4 8.3 0.3 2.4 2 1 0 2 2 2 0 Golgi-dynamics membrane-trafficking GvpL_GvpF PF06386.6 CDI82281.1 - 9.1 5.7 12.5 0.5 9.9 2.6 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF EIF_2_alpha PF07541.7 CDI82282.1 - 2.5e-26 91.6 0.0 2.7e-26 91.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit Mitoc_L55 PF09776.4 CDI82285.1 - 0.17 11.4 0.9 2.9 7.5 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L55 DUF3071 PF11268.3 CDI82290.1 - 0.056 13.1 0.1 0.086 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) TFIIA PF03153.8 CDI82291.1 - 0.0072 16.2 25.4 0.011 15.7 17.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI82291.1 - 0.011 14.0 29.8 0.015 13.5 20.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.14 CDI82291.1 - 0.019 15.3 0.5 0.019 15.3 0.3 4.0 3 1 1 4 4 4 0 60s Acidic ribosomal protein DUF4407 PF14362.1 CDI82291.1 - 1.5 7.7 21.0 2.4 7.0 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2229 PF09989.4 CDI82291.1 - 1.5 8.1 0.0 1.5 8.1 0.0 3.2 3 1 1 4 4 4 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF4551 PF15087.1 CDI82291.1 - 2.1 6.5 19.2 0.49 8.6 10.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4551) APH PF01636.18 CDI82291.1 - 3.7 7.2 7.9 10 5.7 5.3 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family CENP-T PF15511.1 CDI82291.1 - 9.3 5.3 32.0 6.1 5.9 16.8 2.2 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T ATP-synt_D PF01813.12 CDI82294.1 - 2.2e-20 73.0 0.0 2.6e-20 72.8 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit D DUF1895 PF08988.5 CDI82294.1 - 0.072 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1895) GAS PF13851.1 CDI82294.1 - 0.13 11.4 0.1 0.16 11.1 0.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Trypan_PARP PF05887.6 CDI82295.1 - 0.015 15.0 17.7 0.03 14.1 12.3 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Tmemb_9 PF05434.6 CDI82295.1 - 0.017 14.9 2.4 0.35 10.6 0.1 2.2 2 0 0 2 2 2 0 TMEM9 Gastrin PF00918.12 CDI82295.1 - 0.035 14.9 6.1 0.035 14.9 4.2 2.1 1 1 1 2 2 2 0 Gastrin/cholecystokinin family ExbD PF02472.11 CDI82295.1 - 0.29 11.1 2.1 0.62 10.0 1.5 1.6 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DUF966 PF06136.8 CDI82295.1 - 0.37 10.1 8.6 0.45 9.8 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Nop14 PF04147.7 CDI82295.1 - 1.2 6.9 13.0 1.6 6.5 9.0 1.2 1 0 0 1 1 1 0 Nop14-like family DUF4647 PF15504.1 CDI82295.1 - 6.9 5.4 12.2 9 5.0 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) IQ PF00612.22 CDI82298.1 - 0.027 14.0 0.4 4.1 7.3 0.1 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF3382 PF11862.3 CDI82298.1 - 0.72 9.7 5.8 2.6 8.0 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) DNA_pol_B PF00136.16 CDI82300.1 - 1.7e-36 126.0 0.6 2.2e-36 125.6 0.4 1.1 1 0 0 1 1 1 1 DNA polymerase family B FimP PF09766.4 CDI82300.1 - 0.0048 16.0 2.9 0.0048 16.0 2.0 2.1 2 0 0 2 2 2 1 Fms-interacting protein Spt20 PF12090.3 CDI82300.1 - 0.0052 16.1 6.5 0.048 13.0 0.8 2.4 2 0 0 2 2 2 2 Spt20 family DUF2201_N PF13203.1 CDI82300.1 - 0.0083 15.3 5.6 0.29 10.2 0.8 2.2 2 0 0 2 2 2 2 Putative metallopeptidase domain DUF2722 PF10846.3 CDI82300.1 - 0.014 14.4 5.5 0.044 12.8 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DDHD PF02862.12 CDI82300.1 - 0.03 14.1 3.9 0.056 13.2 1.2 2.0 2 0 0 2 2 2 0 DDHD domain Zn-ribbon_8 PF09723.5 CDI82300.1 - 0.094 12.6 0.2 0.094 12.6 0.2 2.3 2 1 1 3 3 2 0 Zinc ribbon domain Neur_chan_memb PF02932.11 CDI82300.1 - 0.12 12.2 1.2 0.16 11.8 0.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TSA PF03249.8 CDI82300.1 - 0.12 10.9 27.2 0.048 12.1 5.4 2.2 2 0 0 2 2 2 0 Type specific antigen LIM PF00412.17 CDI82300.1 - 0.37 10.8 3.9 2.2 8.3 1.0 2.8 2 1 0 2 2 2 0 LIM domain RAB3GAP2_N PF14655.1 CDI82300.1 - 0.41 9.5 9.4 0.54 9.2 1.9 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Dehydrin PF00257.14 CDI82300.1 - 0.82 9.9 9.3 3.7 7.8 1.1 2.3 2 0 0 2 2 2 0 Dehydrin Med15 PF09606.5 CDI82300.1 - 1.3 7.1 35.6 2.1 6.4 24.7 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BRF1 PF07741.8 CDI82300.1 - 2 8.7 10.9 6.6 7.0 3.8 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF16 PF01519.11 CDI82300.1 - 4.1 7.6 21.1 0.2 11.9 1.9 2.9 3 0 0 3 3 3 0 Protein of unknown function DUF16 TMEM51 PF15345.1 CDI82300.1 - 5.4 6.6 11.5 7.8 6.1 3.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 PHD_3 PF13922.1 CDI82300.1 - 5.6 7.2 21.7 13 6.1 1.3 3.6 3 0 0 3 3 3 0 PHD domain of transcriptional enhancer, Asx DUF3306 PF11748.3 CDI82300.1 - 7.6 7.2 14.0 7.3 7.2 2.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DAO PF01266.19 CDI82301.1 - 5.8e-11 41.8 0.1 8.8e-11 41.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF3759 PF12585.3 CDI82301.1 - 0.67 9.9 2.8 5.8 6.8 1.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3759) PP2C PF00481.16 CDI82303.1 - 7.5e-06 25.5 0.0 0.014 14.7 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C DEC-1_N PF04625.8 CDI82303.1 - 8.6 4.9 10.3 14 4.1 7.1 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ribosomal_L13 PF00572.13 CDI82304.1 - 0.0015 18.5 0.0 0.002 18.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 Herpes_DNAp_acc PF04929.7 CDI82310.1 - 1.5 7.6 4.2 2.1 7.2 2.9 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Histone PF00125.19 CDI82313.1 - 2e-21 75.9 0.1 2.6e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDI82313.1 - 0.00013 21.9 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TRAP_alpha PF03896.11 CDI82318.1 - 0.0021 17.0 2.2 0.0039 16.2 1.5 1.4 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit TMEM51 PF15345.1 CDI82318.1 - 0.0033 17.1 5.4 0.0033 17.1 3.7 2.3 3 0 0 3 3 2 1 Transmembrane protein 51 Spore_coat_CotO PF14153.1 CDI82318.1 - 0.0035 16.7 7.8 0.0081 15.6 5.4 1.7 1 0 0 1 1 1 1 Spore coat protein CotO DUF1510 PF07423.6 CDI82318.1 - 0.0058 16.0 10.4 0.0058 16.0 7.2 2.0 2 1 1 3 3 3 1 Protein of unknown function (DUF1510) Potyvirid-P3 PF13608.1 CDI82318.1 - 0.0087 15.2 0.8 0.0087 15.2 0.5 1.6 2 0 0 2 2 2 1 Protein P3 of Potyviral polyprotein CENP-B_dimeris PF09026.5 CDI82318.1 - 0.022 14.9 6.5 0.022 14.9 4.5 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Peptidase_S49_N PF08496.5 CDI82318.1 - 0.028 14.1 1.6 0.07 12.9 1.1 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal S-methyl_trans PF02574.11 CDI82318.1 - 0.032 13.5 0.6 0.06 12.6 0.4 1.5 1 1 0 1 1 1 0 Homocysteine S-methyltransferase Ycf1 PF05758.7 CDI82318.1 - 0.04 11.6 2.4 0.045 11.4 1.7 1.1 1 0 0 1 1 1 0 Ycf1 IncA PF04156.9 CDI82318.1 - 0.21 11.1 12.2 0.42 10.1 8.4 1.4 1 0 0 1 1 1 0 IncA protein NOA36 PF06524.7 CDI82318.1 - 0.46 9.6 6.5 1 8.5 4.5 1.5 1 0 0 1 1 1 0 NOA36 protein CemA PF03040.9 CDI82318.1 - 0.49 9.9 1.4 0.77 9.3 1.0 1.2 1 0 0 1 1 1 0 CemA family Serinc PF03348.10 CDI82318.1 - 0.88 8.2 3.4 1.4 7.5 2.3 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) BTV_NS2 PF04514.7 CDI82318.1 - 1 8.1 11.7 2.2 7.0 8.1 1.5 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF913 PF06025.7 CDI82318.1 - 2.4 6.8 7.3 0.63 8.7 2.8 1.7 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.10 CDI82318.1 - 2.7 6.5 12.8 0.6 8.6 6.8 1.4 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein DDRGK PF09756.4 CDI82318.1 - 2.9 7.2 19.0 5.9 6.2 13.1 1.4 1 0 0 1 1 1 0 DDRGK domain Sod_Fe_C PF02777.13 CDI82321.1 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain RNase_T PF00929.19 CDI82322.1 - 2.8e-17 63.5 0.0 5.5e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Exonuclease Myc_N PF01056.13 CDI82322.1 - 2.3e-05 23.7 8.5 0.073 12.2 3.9 3.2 3 0 0 3 3 3 3 Myc amino-terminal region Cwf_Cwc_15 PF04889.7 CDI82322.1 - 1.6 8.4 17.8 0.46 10.1 7.2 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Vfa1 PF08432.5 CDI82322.1 - 4.5 7.2 13.2 16 5.4 6.4 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CKS PF01111.14 CDI82323.1 - 1.9e-06 27.6 0.2 3e-06 26.9 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit TraG-D_C PF12696.2 CDI82323.1 - 4.8 7.0 8.8 7.8 6.3 5.1 2.1 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Utp14 PF04615.8 CDI82323.1 - 6.4 4.8 30.4 9.3 4.2 21.1 1.2 1 0 0 1 1 1 0 Utp14 protein DUF3550 PF12070.3 CDI82325.1 - 0.22 10.2 1.0 0.3 9.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3550/UPF0682) GBP PF02263.14 CDI82329.1 - 1.8e-27 96.0 0.1 1.3e-18 67.0 0.0 3.2 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 CDI82329.1 - 0.00022 20.4 0.0 0.0003 20.0 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Dynamin_N PF00350.18 CDI82329.1 - 0.0016 18.3 0.6 2.1 8.1 0.0 2.4 2 0 0 2 2 2 2 Dynamin family Miro PF08477.8 CDI82329.1 - 0.31 11.5 1.0 41 4.6 0.0 3.2 3 0 0 3 3 3 0 Miro-like protein LRR_9 PF14580.1 CDI82331.1 - 1.1e-29 103.2 0.1 1.2e-29 103.0 0.1 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 CDI82331.1 - 1.3e-09 37.6 13.2 1.2e-05 24.9 2.6 2.4 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.2 CDI82331.1 - 7.9e-08 31.7 13.2 3.7e-05 23.2 3.4 3.0 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CDI82331.1 - 0.0016 18.1 8.2 8.5 6.8 0.1 4.2 3 1 1 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.1 CDI82331.1 - 1.3 9.2 9.4 7.9 6.8 0.1 3.6 3 1 1 4 4 4 0 Leucine Rich repeat LRR_7 PF13504.1 CDI82331.1 - 7.6 7.2 8.4 16 6.2 0.5 4.0 4 1 0 4 4 4 0 Leucine rich repeat AAA_8 PF12780.2 CDI82333.1 - 6.7e-20 71.1 0.9 2.4e-11 43.1 0.1 3.0 2 1 0 2 2 2 2 P-loop containing dynein motor region D4 Ctr PF04145.10 CDI82333.1 - 0.035 14.1 1.1 0.035 14.1 0.8 2.9 3 0 0 3 3 3 0 Ctr copper transporter family Gag_spuma PF03276.9 CDI82333.1 - 1.4 7.1 19.0 1.2 7.3 10.2 2.3 2 0 0 2 2 2 0 Spumavirus gag protein Ribosomal_60s PF00428.14 CDI82333.1 - 2.2 8.7 16.5 3.1 8.2 0.1 3.1 4 0 0 4 4 4 0 60s Acidic ribosomal protein DHFR_1 PF00186.14 CDI82334.1 - 5.4e-16 58.5 0.0 7.3e-07 28.9 0.0 2.2 2 0 0 2 2 2 2 Dihydrofolate reductase Med3 PF11593.3 CDI82334.1 - 0.057 12.6 14.1 0.065 12.4 9.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Dynein_heavy PF03028.10 CDI82336.1 - 9.3e-61 205.7 0.0 1e-60 205.6 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Glyco_transf_20 PF00982.16 CDI82338.1 - 3.5e-07 29.0 0.0 7.2e-07 28.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 20 Pescadillo_N PF06732.6 CDI82338.1 - 0.019 14.2 1.4 0.038 13.2 1.0 1.4 1 0 0 1 1 1 0 Pescadillo N-terminus AAA_23 PF13476.1 CDI82338.1 - 0.046 14.0 8.5 0.065 13.5 5.9 1.3 1 0 0 1 1 1 0 AAA domain Pox_Ag35 PF03286.9 CDI82338.1 - 0.37 10.2 11.7 1.1 8.6 4.0 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FAM176 PF14851.1 CDI82338.1 - 0.62 9.7 5.5 0.15 11.7 1.3 1.9 2 0 0 2 2 2 0 FAM176 family Baculo_PP31 PF05311.6 CDI82338.1 - 0.65 9.2 7.6 1.2 8.3 5.3 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) TT_ORF1 PF02956.9 CDI82338.1 - 1.4 7.3 7.3 2 6.7 5.0 1.2 1 0 0 1 1 1 0 TT viral orf 1 Suf PF05843.9 CDI82338.1 - 1.7 8.2 16.6 2.8 7.6 7.0 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Plasmodium_Vir PF05795.6 CDI82338.1 - 6.9 5.7 6.3 3.2 6.8 0.7 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DDHD PF02862.12 CDI82338.1 - 7.4 6.3 13.3 5.8 6.6 5.8 2.1 2 0 0 2 2 2 0 DDHD domain Secretin_N_2 PF07655.8 CDI82344.1 - 0.16 12.3 9.9 0.039 14.3 3.9 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain BAF1_ABF1 PF04684.8 CDI82349.1 - 0.021 13.7 29.6 0.023 13.5 20.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Med15 PF09606.5 CDI82349.1 - 0.042 12.0 36.2 0.048 11.8 25.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Pex14_N PF04695.8 CDI82349.1 - 0.075 13.0 11.5 0.095 12.7 8.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3371 PF11851.3 CDI82349.1 - 0.11 13.2 10.7 0.14 12.8 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) PAS_6 PF08348.6 CDI82349.1 - 0.14 11.6 2.1 0.28 10.7 1.5 1.6 1 1 0 1 1 1 0 YheO-like PAS domain SGT1 PF07093.6 CDI82349.1 - 0.24 9.7 13.3 0.25 9.7 9.2 1.0 1 0 0 1 1 1 0 SGT1 protein FAM176 PF14851.1 CDI82349.1 - 0.26 10.9 5.0 0.33 10.6 3.5 1.2 1 0 0 1 1 1 0 FAM176 family DDRGK PF09756.4 CDI82349.1 - 0.27 10.6 14.3 0.3 10.4 9.9 1.1 1 0 0 1 1 1 0 DDRGK domain OmpH PF03938.9 CDI82349.1 - 0.35 10.7 27.9 0.4 10.5 19.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Bud13 PF09736.4 CDI82349.1 - 0.41 10.9 14.1 0.43 10.8 9.8 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex eIF-3_zeta PF05091.7 CDI82349.1 - 0.45 9.0 13.1 0.48 8.9 9.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC45 PF02724.9 CDI82349.1 - 0.47 8.4 9.6 0.53 8.2 6.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Activator_LAG-3 PF11498.3 CDI82349.1 - 0.5 9.0 36.5 0.58 8.8 25.3 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spore_III_AF PF09581.5 CDI82349.1 - 0.52 10.1 7.7 0.51 10.1 5.4 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF4647 PF15504.1 CDI82349.1 - 0.58 8.9 12.2 0.61 8.8 8.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Fimbrial_K88 PF02432.10 CDI82349.1 - 0.61 9.4 9.5 0.66 9.3 6.6 1.1 1 0 0 1 1 1 0 Fimbrial, major and minor subunit CRF1 PF10380.4 CDI82349.1 - 0.65 10.3 4.2 0.81 10.0 2.9 1.3 1 0 0 1 1 1 0 Transcription factor CRF1 Hom_end_hint PF05203.11 CDI82349.1 - 0.66 9.6 8.1 0.69 9.6 5.6 1.1 1 0 0 1 1 1 0 Hom_end-associated Hint DUF2407_C PF13373.1 CDI82349.1 - 0.72 9.7 8.4 0.85 9.5 5.9 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF2217 PF10265.4 CDI82349.1 - 0.76 8.4 8.7 0.83 8.3 6.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) PAT1 PF09770.4 CDI82349.1 - 0.77 7.9 25.3 0.81 7.8 17.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Na_trans_assoc PF06512.8 CDI82349.1 - 0.85 9.5 7.7 0.91 9.4 5.3 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Spt5_N PF11942.3 CDI82349.1 - 0.86 10.2 9.0 1 10.0 6.3 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF2228 PF10228.4 CDI82349.1 - 0.88 9.0 6.8 1 8.8 4.7 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) Band_3_cyto PF07565.8 CDI82349.1 - 1 8.8 11.6 1.1 8.6 8.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CDC73 PF05179.9 CDI82349.1 - 1.1 8.5 10.8 1.2 8.4 7.5 1.0 1 0 0 1 1 1 0 RNA pol II accessory factor, Cdc73 family Pex16 PF08610.5 CDI82349.1 - 1.2 8.0 6.3 1.2 8.0 4.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Gti1_Pac2 PF09729.4 CDI82349.1 - 1.3 8.9 6.8 1.5 8.7 4.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4316 PF14195.1 CDI82349.1 - 1.3 9.1 7.7 2.1 8.4 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) CPSF100_C PF13299.1 CDI82349.1 - 1.3 9.1 10.3 1.5 8.9 7.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.1 CDI82349.1 - 1.5 6.4 28.8 1.7 6.2 20.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FliP PF00813.15 CDI82349.1 - 1.5 8.5 8.3 1.6 8.3 5.7 1.1 1 0 0 1 1 1 0 FliP family YABBY PF04690.8 CDI82349.1 - 1.5 9.0 7.1 1.6 8.9 4.9 1.2 1 0 0 1 1 1 0 YABBY protein FAM60A PF15396.1 CDI82349.1 - 1.7 8.3 9.6 1.8 8.2 6.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A AP-5_subunit_s1 PF15001.1 CDI82349.1 - 1.7 8.5 10.3 1.9 8.3 7.2 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Lin-8 PF03353.10 CDI82349.1 - 1.8 7.7 17.2 2 7.6 11.9 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PP_M1 PF03012.9 CDI82349.1 - 1.8 7.8 11.7 2 7.7 8.1 1.0 1 0 0 1 1 1 0 Phosphoprotein DUF4557 PF15101.1 CDI82349.1 - 2.2 8.0 18.0 2.5 7.9 12.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Nop25 PF09805.4 CDI82349.1 - 2.3 8.2 15.0 2.5 8.1 10.4 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) DUF1762 PF08574.5 CDI82349.1 - 2.4 8.6 5.3 3.1 8.2 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1762) Endonuc_Holl PF10107.4 CDI82349.1 - 2.4 7.8 9.3 2.7 7.6 6.5 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Cellulose_synt PF03552.9 CDI82349.1 - 2.5 6.2 5.2 2.4 6.3 3.6 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF966 PF06136.8 CDI82349.1 - 2.5 7.4 13.5 2.7 7.3 9.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Peptidase_C58 PF03543.9 CDI82349.1 - 2.7 7.4 17.4 2.9 7.3 12.1 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen HSP70 PF00012.15 CDI82349.1 - 2.8 5.7 14.6 2.9 5.7 10.1 1.0 1 0 0 1 1 1 0 Hsp70 protein F-protein PF00469.15 CDI82349.1 - 3.1 7.1 9.6 3.1 7.1 6.7 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef CIAPIN1 PF05093.8 CDI82349.1 - 3.2 7.9 11.0 5.1 7.2 7.5 1.4 1 1 1 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Mgr1 PF08602.5 CDI82349.1 - 3.2 6.6 6.4 3.2 6.6 4.4 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit PIH1 PF08190.7 CDI82349.1 - 3.6 6.9 15.3 3.9 6.8 10.6 1.0 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 Neur_chan_memb PF02932.11 CDI82349.1 - 3.6 7.4 9.4 3.8 7.3 6.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3573 PF12097.3 CDI82349.1 - 3.7 6.0 8.9 3.7 6.0 6.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF3533 PF12051.3 CDI82349.1 - 3.9 6.1 9.0 4.2 6.0 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Ycf1 PF05758.7 CDI82349.1 - 4.5 4.8 10.5 4.3 4.9 7.3 1.0 1 0 0 1 1 1 0 Ycf1 Hid1 PF12722.2 CDI82349.1 - 4.7 4.7 12.4 4.8 4.7 8.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAE2 PF08573.5 CDI82349.1 - 5 7.9 12.2 6.3 7.5 8.5 1.3 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Glyco_transf_15 PF01793.11 CDI82349.1 - 5 5.9 9.9 5.3 5.8 6.8 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Suf PF05843.9 CDI82349.1 - 5.1 6.7 11.7 5.4 6.6 8.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Otopetrin PF03189.8 CDI82349.1 - 5.6 5.8 7.0 6.4 5.6 4.8 1.0 1 0 0 1 1 1 0 Otopetrin Shisa PF13908.1 CDI82349.1 - 5.7 7.0 13.4 6.5 6.8 9.3 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CDK5_activator PF03261.10 CDI82349.1 - 5.8 6.1 12.7 5.6 6.1 8.8 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DNA_pol_viral_N PF00242.12 CDI82349.1 - 5.9 5.8 10.4 6.6 5.6 7.2 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DDHD PF02862.12 CDI82349.1 - 6 6.5 9.5 6 6.5 6.6 1.1 1 0 0 1 1 1 0 DDHD domain LCD1 PF09798.4 CDI82349.1 - 6.8 4.5 10.0 6.6 4.5 7.0 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein DXP_reductoisom PF02670.11 CDI82349.1 - 6.8 7.2 10.4 7.4 7.1 7.2 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase FimP PF09766.4 CDI82349.1 - 6.9 5.6 18.7 7.6 5.4 13.0 1.1 1 0 0 1 1 1 0 Fms-interacting protein HlyD_2 PF12700.2 CDI82349.1 - 7 5.7 10.5 7.3 5.6 7.3 1.1 1 0 0 1 1 1 0 HlyD family secretion protein UPF0560 PF10577.4 CDI82349.1 - 7.2 4.7 16.5 7.5 4.6 11.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2486 PF10667.4 CDI82349.1 - 8.5 6.8 20.9 9.6 6.6 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) Spc24 PF08286.6 CDI82349.1 - 8.9 6.0 11.8 11 5.6 8.2 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4139 PF13598.1 CDI82349.1 - 9.4 5.4 15.2 11 5.1 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) Peptidase_U57 PF05582.7 CDI82349.1 - 9.5 5.0 9.9 10 4.9 6.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 DUF288 PF03385.12 CDI82350.1 - 0.018 13.4 8.2 0.022 13.2 5.7 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF288 Spore_coat_CotO PF14153.1 CDI82350.1 - 0.31 10.4 28.6 0.37 10.2 19.8 1.0 1 0 0 1 1 1 0 Spore coat protein CotO G-7-MTase PF12803.2 CDI82350.1 - 0.55 9.3 7.0 0.6 9.1 4.8 1.0 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) PAT1 PF09770.4 CDI82350.1 - 0.61 8.2 35.6 0.69 8.0 24.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI82350.1 - 0.64 7.6 16.9 0.64 7.6 11.7 1.0 1 0 0 1 1 1 0 Ycf1 Zip PF02535.17 CDI82350.1 - 1.1 8.2 2.5 1.2 8.0 1.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Dehalogenase PF13486.1 CDI82350.1 - 1.5 8.2 10.7 1.8 7.9 7.4 1.2 1 0 0 1 1 1 0 Reductive dehalogenase subunit SOBP PF15279.1 CDI82350.1 - 1.6 9.0 16.8 1.8 8.8 11.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2407_C PF13373.1 CDI82350.1 - 1.8 8.5 11.4 2.2 8.2 7.9 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain FAM60A PF15396.1 CDI82350.1 - 2 8.1 13.8 2.3 7.9 9.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.7 CDI82350.1 - 2 6.9 18.1 2.2 6.7 12.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3474 PF11960.3 CDI82350.1 - 2.2 8.3 5.1 2.8 7.9 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) SID-1_RNA_chan PF13965.1 CDI82350.1 - 3.2 5.8 10.3 3.6 5.6 7.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FHIPEP PF00771.15 CDI82350.1 - 3.2 5.9 12.9 3.8 5.7 8.9 1.1 1 0 0 1 1 1 0 FHIPEP family SAGA-Tad1 PF12767.2 CDI82350.1 - 3.3 7.3 23.0 3.8 7.1 15.9 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit OmpH PF03938.9 CDI82350.1 - 3.3 7.6 41.7 3.8 7.4 28.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CDC45 PF02724.9 CDI82350.1 - 3.3 5.6 16.8 3.6 5.5 11.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.11 CDI82350.1 - 4.1 6.7 14.8 5.1 6.4 10.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Paramyxo_ncap PF00973.14 CDI82350.1 - 4.5 5.8 12.4 4.7 5.7 8.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AUX_IAA PF02309.11 CDI82350.1 - 5 6.8 13.8 6.2 6.4 9.6 1.2 1 0 0 1 1 1 0 AUX/IAA family DUF2052 PF09747.4 CDI82350.1 - 5 6.9 26.8 6.7 6.5 18.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4638 PF15472.1 CDI82350.1 - 5.7 6.4 18.6 7 6.1 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DHHW PF14286.1 CDI82350.1 - 5.7 6.1 10.2 6.5 5.9 7.1 1.1 1 0 0 1 1 1 0 DHHW protein N6_N4_Mtase PF01555.13 CDI82350.1 - 6.3 6.2 9.0 7.8 5.9 6.2 1.3 1 0 0 1 1 1 0 DNA methylase DUF4175 PF13779.1 CDI82350.1 - 6.4 4.3 48.2 7.3 4.1 33.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Asp-B-Hydro_N PF05279.6 CDI82350.1 - 7 6.4 15.9 8.5 6.1 11.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CAF-1_p150 PF11600.3 CDI82350.1 - 8 5.7 31.7 9.9 5.4 22.0 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF4220 PF13968.1 CDI82350.1 - 9.6 5.1 8.1 11 4.9 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) FliP PF00813.15 CDI82350.1 - 9.8 5.8 8.2 12 5.5 5.7 1.1 1 0 0 1 1 1 0 FliP family Lipoprotein_X PF03305.8 CDI82350.1 - 10 5.4 12.0 12 5.2 8.3 1.1 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein CDC45 PF02724.9 CDI82352.1 - 0.095 10.7 3.7 0.11 10.5 2.6 1.2 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.10 CDI82352.1 - 0.13 10.8 3.3 0.18 10.3 2.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ycf1 PF05758.7 CDI82352.1 - 0.29 8.7 3.2 0.32 8.6 2.2 1.1 1 0 0 1 1 1 0 Ycf1 OmpH PF03938.9 CDI82352.1 - 1.5 8.7 18.7 0.35 10.7 10.6 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ThiF PF00899.16 CDI82353.1 - 1.1e-30 106.2 0.2 6e-30 103.8 0.1 2.3 1 1 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.4 CDI82353.1 - 7.2e-13 47.6 0.5 1.5e-12 46.6 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UBACT PF02134.16 CDI82353.1 - 2.9e-09 36.3 3.1 2.9e-09 36.3 2.2 2.8 1 1 1 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein UAE_UbL PF14732.1 CDI82353.1 - 0.0035 17.4 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain DUF2229 PF09989.4 CDI82353.1 - 0.071 12.5 0.0 0.071 12.5 0.0 2.3 3 0 0 3 3 3 0 CoA enzyme activase uncharacterised domain (DUF2229) Med15 PF09606.5 CDI82354.1 - 2.4 6.2 42.4 0.14 10.3 24.7 1.9 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SSP160 PF06933.6 CDI82355.1 - 0.52 8.2 7.1 0.71 7.7 4.9 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CRAL_TRIO_N PF03765.10 CDI82356.1 - 6.3e-05 23.0 0.1 6.3e-05 23.0 0.1 2.6 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain PIH1 PF08190.7 CDI82356.1 - 0.0055 16.2 22.2 0.0055 16.2 15.4 2.3 2 1 0 2 2 2 1 pre-RNA processing PIH1/Nop17 DUF1510 PF07423.6 CDI82356.1 - 0.12 11.6 44.8 0.31 10.3 14.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 CDI82356.1 - 1 7.2 44.3 0.041 11.9 13.2 2.0 2 0 0 2 2 2 0 CDC45-like protein CRT10 PF08728.5 CDI82356.1 - 1.4 6.8 18.7 2.1 6.2 13.0 1.2 1 0 0 1 1 1 0 CRT10 PAT1 PF09770.4 CDI82356.1 - 7.4 4.6 83.6 0.73 8.0 37.5 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Vfa1 PF08432.5 CDI82356.1 - 9.8 6.1 46.5 2.8 7.9 16.0 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 LRR_6 PF13516.1 CDI82357.1 - 0.0083 16.0 1.0 8.7 6.7 0.0 3.4 2 1 1 3 3 3 2 Leucine Rich repeat DUF3096 PF11295.3 CDI82359.1 - 0.063 12.7 0.2 0.063 12.7 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3096) Hemocyanin_C PF03723.9 CDI82365.1 - 0.049 12.7 3.1 0.042 12.9 1.4 1.4 1 1 0 1 1 1 0 Hemocyanin, ig-like domain VIT1 PF01988.14 CDI82365.1 - 0.051 13.0 0.7 0.052 13.0 0.5 1.2 1 0 0 1 1 1 0 VIT family CPSF73-100_C PF11718.3 CDI82365.1 - 0.094 12.0 5.6 0.1 11.9 3.9 1.2 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Serinc PF03348.10 CDI82365.1 - 0.14 10.8 10.1 0.14 10.8 7.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2217 PF10265.4 CDI82365.1 - 0.19 10.4 3.8 0.19 10.4 2.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Dynamin_N PF00350.18 CDI82365.1 - 0.35 10.6 4.8 0.39 10.5 3.3 1.2 1 0 0 1 1 1 0 Dynamin family FHIPEP PF00771.15 CDI82365.1 - 0.37 9.0 6.8 0.36 9.0 4.7 1.2 1 0 0 1 1 1 0 FHIPEP family Folate_carrier PF01770.13 CDI82365.1 - 0.37 9.2 4.5 0.44 9.0 3.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier CD20 PF04103.10 CDI82365.1 - 0.4 10.6 5.9 0.086 12.7 1.9 1.4 2 0 0 2 2 1 0 CD20-like family SR-25 PF10500.4 CDI82365.1 - 0.41 10.0 11.0 0.46 9.9 7.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Trp_oprn_chp PF09534.5 CDI82365.1 - 0.61 9.6 8.9 0.061 12.9 3.3 1.5 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Peroxin-13_N PF04088.8 CDI82365.1 - 0.67 9.8 5.7 1.1 9.2 4.0 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Zip PF02535.17 CDI82365.1 - 0.84 8.5 6.9 0.84 8.5 4.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_U57 PF05582.7 CDI82365.1 - 1.1 8.1 9.2 1.4 7.7 6.4 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Band_3_cyto PF07565.8 CDI82365.1 - 1.1 8.7 12.6 1.4 8.3 8.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3824 PF12868.2 CDI82365.1 - 1.2 10.0 12.2 1.5 9.7 8.5 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) BNR_3 PF13859.1 CDI82365.1 - 1.4 7.9 5.0 1.4 7.9 3.5 1.1 1 0 0 1 1 1 0 BNR repeat-like domain FimP PF09766.4 CDI82365.1 - 1.8 7.5 24.3 0.17 10.9 13.0 1.8 2 0 0 2 2 2 0 Fms-interacting protein DUF2215 PF10225.4 CDI82365.1 - 1.9 7.8 6.7 2 7.7 4.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) DUF2232 PF09991.4 CDI82365.1 - 2 7.3 7.2 3.1 6.7 5.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF3373 PF11853.3 CDI82365.1 - 2.4 6.5 10.8 2.3 6.6 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) FGF-BP1 PF06473.7 CDI82365.1 - 2.6 7.5 15.1 2.9 7.4 10.5 1.1 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Herpes_glycop PF01528.11 CDI82365.1 - 2.8 6.5 5.3 2.8 6.5 3.7 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M AUX_IAA PF02309.11 CDI82365.1 - 3.4 7.3 12.5 4.1 7.0 8.7 1.2 1 0 0 1 1 1 0 AUX/IAA family FAM60A PF15396.1 CDI82365.1 - 5.6 6.6 12.0 7.3 6.2 8.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A AIF_C PF14721.1 CDI82365.1 - 5.9 7.1 14.6 1.3 9.2 7.7 1.6 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tim54 PF11711.3 CDI82365.1 - 6 5.3 13.2 6.7 5.1 9.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Hom_end_hint PF05203.11 CDI82365.1 - 6 6.5 12.7 7 6.3 8.8 1.1 1 0 0 1 1 1 0 Hom_end-associated Hint FAM176 PF14851.1 CDI82365.1 - 6.8 6.3 8.1 8 6.1 5.6 1.3 1 1 0 1 1 1 0 FAM176 family SID-1_RNA_chan PF13965.1 CDI82365.1 - 7 4.6 6.2 6.4 4.8 4.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Dicty_REP PF05086.7 CDI82365.1 - 8.8 3.9 12.3 7.7 4.1 8.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pal1 PF08316.6 CDI82365.1 - 9 6.7 11.2 5.6 7.4 6.9 1.4 1 1 0 1 1 1 0 Pal1 cell morphology protein Myosin_head PF00063.16 CDI82366.1 - 5.5e-27 94.1 0.0 8.1e-27 93.5 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Prp31_C PF09785.4 CDI82370.1 - 1.1e-07 32.2 0.1 1.1e-07 32.2 0.1 2.2 2 1 0 2 2 2 1 Prp31 C terminal domain Sporozoite_P67 PF05642.6 CDI82370.1 - 0.49 8.2 5.2 0.61 7.8 3.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FKBP_N PF01346.13 CDI82372.1 - 0.0034 17.4 6.1 0.0047 16.9 4.3 1.2 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Med15 PF09606.5 CDI82372.1 - 0.013 13.7 25.0 0.013 13.7 17.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SAGA-Tad1 PF12767.2 CDI82372.1 - 0.074 12.7 9.4 0.09 12.4 6.5 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF3313 PF11769.3 CDI82372.1 - 0.083 12.2 2.7 0.12 11.7 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) LCD1 PF09798.4 CDI82372.1 - 0.18 9.7 10.3 0.19 9.7 7.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein FAM150 PF15129.1 CDI82372.1 - 0.32 10.8 2.9 0.49 10.2 2.0 1.3 1 1 0 1 1 1 0 FAM150 family DUF4175 PF13779.1 CDI82372.1 - 0.34 8.5 19.8 0.33 8.6 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) HlyD_2 PF12700.2 CDI82372.1 - 0.4 9.7 7.8 0.45 9.6 5.4 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DUF3446 PF11928.3 CDI82372.1 - 0.65 10.2 7.6 0.79 9.9 3.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3446) FCP1_C PF09309.5 CDI82372.1 - 0.88 8.8 7.7 1.3 8.3 5.3 1.3 1 0 0 1 1 1 0 FCP1, C-terminal PAT1 PF09770.4 CDI82372.1 - 0.92 7.6 21.5 0.98 7.5 14.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3300 PF11737.3 CDI82372.1 - 1.1 8.4 10.3 1.5 8.0 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3300) SLD3 PF08639.5 CDI82372.1 - 1.1 7.7 12.1 1.3 7.5 8.4 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 DivIC PF04977.10 CDI82372.1 - 1.6 8.2 16.0 3.4 7.2 11.1 1.5 1 0 0 1 1 1 0 Septum formation initiator SR-25 PF10500.4 CDI82372.1 - 9.6 5.5 21.5 0.91 8.9 6.1 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Acetyltransf_1 PF00583.19 CDI82373.1 - 2.2e-17 62.8 0.1 3.2e-17 62.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CDI82373.1 - 2e-10 40.6 0.0 3.1e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDI82373.1 - 1.8e-09 37.7 0.0 4.5e-09 36.4 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CDI82373.1 - 9.9e-07 29.0 0.0 1.7e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CDI82373.1 - 4.1e-06 26.7 0.0 6.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CDI82373.1 - 1.4e-05 24.8 0.1 4.7e-05 23.1 0.0 1.8 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase FR47 PF08445.5 CDI82373.1 - 3.6e-05 23.4 0.0 5.9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 CDI82373.1 - 0.00059 19.6 0.0 0.002 17.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CDI82373.1 - 0.0049 16.8 0.0 0.0091 15.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pex14_N PF04695.8 CDI82374.1 - 0.0042 17.1 9.5 0.0042 17.1 6.6 2.8 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region BTV_NS2 PF04514.7 CDI82374.1 - 0.098 11.5 8.2 0.034 13.0 3.8 1.5 2 0 0 2 2 2 0 Bluetongue virus non-structural protein NS2 DUF4518 PF15008.1 CDI82374.1 - 0.15 11.0 6.5 0.31 10.0 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) Folate_carrier PF01770.13 CDI82374.1 - 0.17 10.3 6.2 0.29 9.6 4.3 1.3 1 0 0 1 1 1 0 Reduced folate carrier Na_trans_assoc PF06512.8 CDI82374.1 - 0.22 11.4 11.7 0.77 9.6 3.8 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated DUF775 PF05603.7 CDI82374.1 - 0.23 10.9 15.3 0.26 10.7 6.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF775) YjgP_YjgQ PF03739.9 CDI82374.1 - 0.24 10.1 1.2 0.37 9.5 0.9 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DDRGK PF09756.4 CDI82374.1 - 0.24 10.8 15.0 0.4 10.0 10.4 1.3 1 0 0 1 1 1 0 DDRGK domain V_ATPase_I PF01496.14 CDI82374.1 - 0.52 8.1 2.6 0.69 7.6 1.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.8 CDI82374.1 - 1.2 8.5 9.3 0.23 10.9 3.1 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain SR-25 PF10500.4 CDI82374.1 - 1.8 7.9 26.7 2.1 7.7 6.7 2.5 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4638 PF15472.1 CDI82374.1 - 2 7.9 8.9 4.6 6.7 5.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) CD20 PF04103.10 CDI82374.1 - 2.9 7.8 7.0 3 7.7 1.4 2.4 2 0 0 2 2 2 0 CD20-like family Spt20 PF12090.3 CDI82374.1 - 2.9 7.1 12.0 2.7 7.3 7.3 1.7 2 0 0 2 2 2 0 Spt20 family DUF912 PF06024.7 CDI82374.1 - 3.2 7.8 8.2 1.6 8.8 3.7 2.0 2 0 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Peptidase_S49_N PF08496.5 CDI82374.1 - 3.6 7.3 9.4 7.5 6.3 6.5 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RED_N PF07808.8 CDI82374.1 - 4.7 6.3 16.0 9.4 5.3 11.1 1.5 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF1764 PF08576.5 CDI82374.1 - 5.5 7.8 15.0 3.3 8.5 8.5 2.0 2 0 0 2 2 1 0 Eukaryotic protein of unknown function (DUF1764) FAM176 PF14851.1 CDI82374.1 - 6.8 6.3 9.3 1.7 8.2 2.9 2.1 2 0 0 2 2 2 0 FAM176 family BNIP3 PF06553.7 CDI82374.1 - 7.9 5.7 16.4 1.9 7.8 0.8 2.3 2 0 0 2 2 2 0 BNIP3 SeqA PF03925.8 CDI82374.1 - 8.9 5.9 13.6 7.4 6.2 6.5 2.2 2 0 0 2 2 2 0 SeqA protein Serinc PF03348.10 CDI82374.1 - 9.5 4.8 10.1 19 3.8 7.0 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.2 CDI82374.1 - 9.6 3.7 11.7 0.22 9.1 3.3 1.6 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein BAF1_ABF1 PF04684.8 CDI82376.1 - 0.0013 17.6 22.2 0.0013 17.6 15.4 3.8 2 1 1 3 3 3 1 BAF1 / ABF1 chromatin reorganising factor DUF4557 PF15101.1 CDI82376.1 - 0.28 11.0 17.0 1.9 8.2 6.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Spt20 PF12090.3 CDI82376.1 - 0.87 8.9 7.9 1.6 8.0 5.5 1.4 1 0 0 1 1 1 0 Spt20 family Band_3_cyto PF07565.8 CDI82376.1 - 1.5 8.2 8.0 4.9 6.5 5.6 1.9 1 1 0 1 1 1 0 Band 3 cytoplasmic domain Suf PF05843.9 CDI82376.1 - 2.5 7.7 10.0 1.2 8.7 5.1 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Peptidase_M24 PF00557.19 CDI82377.1 - 6.1e-37 127.2 0.0 9.1e-37 126.6 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Med3 PF11593.3 CDI82377.1 - 0.34 10.0 1.3 0.55 9.4 0.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ribosomal_60s PF00428.14 CDI82377.1 - 1.7 9.0 18.1 9.9 6.6 12.5 2.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein FimP PF09766.4 CDI82378.1 - 2.1 7.3 52.6 0.098 11.7 8.6 4.2 4 0 0 4 4 4 0 Fms-interacting protein EXS PF03124.9 CDI82379.1 - 5.6 5.8 0.1 9.8 5.0 0.0 1.3 1 0 0 1 1 1 0 EXS family PAT1 PF09770.4 CDI82380.1 - 1.5 7.0 26.0 1.8 6.7 18.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI82380.1 - 1.8 6.6 43.4 3.1 5.8 30.1 1.4 1 1 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal GATase PF00117.23 CDI82381.1 - 0.027 13.9 0.0 0.038 13.4 0.0 1.2 1 1 0 1 1 1 0 Glutamine amidotransferase class-I Pex14_N PF04695.8 CDI82381.1 - 0.05 13.6 0.7 0.054 13.5 0.5 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CDK2AP PF09806.4 CDI82381.1 - 0.2 11.8 4.5 0.24 11.6 3.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Macoilin PF09726.4 CDI82381.1 - 1.4 7.1 7.6 1.5 6.9 5.3 1.0 1 0 0 1 1 1 0 Transmembrane protein Secretin_N_2 PF07655.8 CDI82381.1 - 2.3 8.6 14.9 3.5 8.0 10.3 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3633 PF12315.3 CDI82381.1 - 2.6 7.3 4.7 3.5 6.8 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) PP1c_bdg PF10488.4 CDI82381.1 - 6 5.9 10.8 7.1 5.7 7.5 1.0 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region DnaJ PF00226.26 CDI82386.1 - 7e-09 35.3 0.6 1.2e-08 34.5 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain DUF3638 PF12340.3 CDI82388.1 - 9.4e-18 64.0 0.1 1.2e-15 57.1 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) CDK2AP PF09806.4 CDI82388.1 - 0.00012 22.3 0.7 0.00012 22.3 0.5 18.5 14 5 0 14 14 14 3 Cyclin-dependent kinase 2-associated protein EF-hand_7 PF13499.1 CDI82389.1 - 8.1e-06 25.8 0.2 2e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 CDI82389.1 - 3.4e-05 23.3 1.3 0.31 11.0 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 CDI82389.1 - 0.00033 19.7 0.0 0.022 14.0 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 CDI82389.1 - 0.12 11.7 2.2 0.086 12.2 0.2 1.8 2 0 0 2 2 2 0 EF hand Enolase_C PF00113.17 CDI82390.1 - 1.1e-135 451.3 0.2 1.4e-135 450.9 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 CDI82390.1 - 2e-40 137.7 0.1 3.2e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MAAL_C PF07476.6 CDI82390.1 - 2.3e-06 26.7 0.1 4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_C PF13378.1 CDI82390.1 - 4.4e-05 23.4 0.0 8.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE PF01188.16 CDI82390.1 - 0.01 16.3 0.0 0.033 14.7 0.0 2.0 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain B3_4 PF03483.12 CDI82391.1 - 0.00018 21.0 0.0 0.00047 19.6 0.0 1.8 1 0 0 1 1 1 1 B3/4 domain Pro-rich PF15240.1 CDI82394.1 - 0.0072 16.4 35.6 0.0091 16.1 24.7 1.1 1 0 0 1 1 1 1 Proline-rich Drf_DAD PF06345.6 CDI82394.1 - 2.2 8.2 3.9 25 4.9 0.1 3.4 3 0 0 3 3 3 0 DRF Autoregulatory Domain Pkinase PF00069.20 CDI82397.1 - 1.8e-15 56.8 0.0 1.9e-14 53.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI82397.1 - 3.8e-07 29.3 0.0 4.4e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_Tyr PF07714.12 CDI82397.1 - 1.8e-05 23.9 0.1 6.9e-05 22.0 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.9 CDI82397.1 - 0.027 13.5 0.0 0.053 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDI82397.1 - 0.076 12.7 0.3 0.55 9.9 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Casc1 PF12366.3 CDI82401.1 - 0.056 12.9 0.0 0.059 12.8 0.0 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 LCD1 PF09798.4 CDI82401.1 - 0.091 10.7 0.1 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein SlyX PF04102.7 CDI82401.1 - 0.12 12.7 0.6 0.19 12.1 0.4 1.3 1 0 0 1 1 1 0 SlyX Kinesin PF00225.18 CDI82403.1 - 3e-75 253.0 6.5 3.1e-54 183.9 0.0 3.0 2 1 1 3 3 3 2 Kinesin motor domain KIF1B PF12423.3 CDI82403.1 - 4.4e-05 23.4 0.6 0.00033 20.6 0.0 2.9 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.21 CDI82403.1 - 0.031 14.3 0.0 0.089 12.9 0.0 1.8 1 0 0 1 1 1 0 FHA domain LMBR1 PF04791.11 CDI82403.1 - 1.1 7.7 6.1 2.2 6.7 4.2 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_13 PF13166.1 CDI82403.1 - 2.7 6.3 29.2 0.54 8.6 0.7 3.2 3 0 0 3 3 3 0 AAA domain DUF4250 PF14056.1 CDI82403.1 - 7.5 6.3 8.6 0.29 10.8 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) Ion_trans PF00520.26 CDI82404.1 - 5.7e-28 97.5 60.5 9.5e-15 54.3 11.6 4.4 4 0 0 4 4 4 4 Ion transport protein ETRAMP PF09716.5 CDI82404.1 - 0.055 13.4 0.2 0.4 10.6 0.0 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.27 CDI82406.1 - 1.2e-10 40.8 10.6 0.095 12.6 0.3 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat DUF1525 PF07511.6 CDI82408.1 - 0.018 15.0 0.6 0.076 13.0 0.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) CCDC-167 PF15188.1 CDI82408.1 - 0.046 13.6 0.5 0.13 12.1 0.4 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 KxDL PF10241.4 CDI82408.1 - 0.19 11.6 2.7 1.6 8.6 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein CDC37_N PF03234.9 CDI82408.1 - 1 9.6 5.2 5.6 7.2 0.7 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Myosin_head PF00063.16 CDI82412.1 - 2.7e-16 58.7 0.2 4e-16 58.2 0.1 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) DUF572 PF04502.8 CDI82413.1 - 0.014 14.6 7.5 0.022 13.9 5.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF3043 PF11241.3 CDI82413.1 - 0.39 10.2 9.4 0.64 9.5 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Spore_coat_CotO PF14153.1 CDI82413.1 - 1.4 8.3 7.3 9.5 5.6 1.3 2.4 2 0 0 2 2 2 0 Spore coat protein CotO DUF2269 PF10027.4 CDI82413.1 - 2.9 7.6 4.5 1.2 8.8 0.2 2.1 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) RAB3GAP2_N PF14655.1 CDI82413.1 - 3.4 6.5 5.8 3.7 6.4 0.9 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3306 PF11748.3 CDI82413.1 - 3.8 8.1 14.0 1.8 9.2 3.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) SDA1 PF05285.7 CDI82414.1 - 0.22 10.7 6.1 0.25 10.5 4.3 1.1 1 0 0 1 1 1 0 SDA1 Daxx PF03344.10 CDI82414.1 - 0.31 9.4 8.2 0.36 9.2 5.7 1.1 1 0 0 1 1 1 0 Daxx Family DUF605 PF04652.11 CDI82414.1 - 0.32 10.3 7.0 0.36 10.1 4.9 1.1 1 0 0 1 1 1 0 Vta1 like DUF1510 PF07423.6 CDI82414.1 - 1.1 8.6 7.8 1.5 8.1 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4407 PF14362.1 CDI82414.1 - 1.3 7.8 5.5 1.9 7.3 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2201_N PF13203.1 CDI82414.1 - 1.6 7.8 6.1 2.1 7.4 4.3 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Spore_coat_CotO PF14153.1 CDI82414.1 - 2.7 7.4 6.0 7 6.0 4.2 1.7 1 1 0 1 1 1 0 Spore coat protein CotO PPP4R2 PF09184.6 CDI82414.1 - 5.6 6.4 10.7 7.9 5.9 7.4 1.2 1 0 0 1 1 1 0 PPP4R2 DDHD PF02862.12 CDI82414.1 - 9.8 5.9 7.7 15 5.3 5.3 1.3 1 0 0 1 1 1 0 DDHD domain SMC_N PF02463.14 CDI82422.1 - 1.9e-17 63.2 2.9 2.5e-17 62.8 2.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDI82422.1 - 1.7e-10 41.3 0.0 2e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 CDI82422.1 - 0.00078 19.3 0.1 0.00078 19.3 0.1 2.3 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit DUF3609 PF12259.3 CDI82422.1 - 0.056 12.0 7.9 0.079 11.6 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3609) AAA_15 PF13175.1 CDI82422.1 - 0.15 11.1 0.1 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TFIIA PF03153.8 CDI82422.1 - 0.86 9.4 30.3 1.2 8.9 21.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Herpes_UL87 PF03043.9 CDI82422.1 - 6.6 4.9 7.8 8.8 4.5 5.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family Methyltransf_7 PF03492.10 CDI82423.1 - 0.071 11.8 0.0 0.079 11.6 0.0 1.1 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase DUF1803 PF08820.5 CDI82423.1 - 0.078 12.6 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) ketoacyl-synt PF00109.21 CDI82427.1 - 2.6e-65 220.4 0.0 1.1e-64 218.4 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 CDI82427.1 - 7.2e-53 179.9 4.1 1.3e-43 149.5 1.3 2.3 1 1 1 2 2 2 2 Acyl transferase domain KR PF08659.5 CDI82427.1 - 1.5e-50 171.3 0.3 4.9e-50 169.7 0.2 1.9 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 CDI82427.1 - 9.7e-40 136.2 0.2 9.7e-40 136.2 0.1 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Ketoacyl-synt_C PF02801.17 CDI82427.1 - 1.9e-31 108.3 0.2 6.6e-31 106.6 0.1 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.7 CDI82427.1 - 1.1e-29 103.1 0.0 9.7e-27 93.4 0.0 2.6 3 0 0 3 3 3 2 Male sterility protein PP-binding PF00550.20 CDI82427.1 - 2.7e-09 37.1 0.5 7.3e-09 35.7 0.4 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 CDI82427.1 - 2.6e-07 30.3 0.1 0.00059 19.3 0.0 3.0 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CDI82427.1 - 3.5e-05 22.8 0.0 0.001 18.0 0.0 2.8 3 1 0 3 3 3 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 CDI82427.1 - 0.00046 20.2 1.5 0.67 9.9 0.1 3.0 2 1 0 2 2 2 2 NADH(P)-binding 3Beta_HSD PF01073.14 CDI82427.1 - 0.024 13.3 0.0 0.059 12.0 0.0 1.6 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family BBS1 PF14779.1 CDI82427.1 - 0.26 10.2 0.0 0.53 9.2 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 Syntaxin-6_N PF09177.6 CDI82429.1 - 4e-17 62.4 8.8 5.4e-17 61.9 1.3 2.3 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 CDI82429.1 - 2.1e-06 27.3 1.6 2.1e-06 27.3 1.1 2.9 3 0 0 3 3 3 1 SNARE domain Nup88 PF10168.4 CDI82429.1 - 0.0047 14.8 7.3 0.006 14.4 5.1 1.1 1 0 0 1 1 1 1 Nuclear pore component AAA_13 PF13166.1 CDI82429.1 - 0.023 13.1 3.2 0.032 12.7 2.2 1.1 1 0 0 1 1 1 0 AAA domain ATG16 PF08614.6 CDI82429.1 - 0.075 12.8 18.3 0.19 11.5 4.5 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CheW PF01584.14 CDI82429.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 CheW-like domain BLOC1_2 PF10046.4 CDI82429.1 - 0.36 10.9 0.1 0.36 10.9 0.0 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Atg14 PF10186.4 CDI82429.1 - 0.51 9.2 12.5 0.51 9.2 4.6 2.1 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF812 PF05667.6 CDI82429.1 - 2.7 6.4 12.9 3.9 5.8 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Tropomyosin_1 PF12718.2 CDI82429.1 - 5.1 6.9 16.7 0.24 11.2 3.6 2.3 2 0 0 2 2 2 0 Tropomyosin like WD40 PF00400.27 CDI82431.1 - 4.6e-15 54.8 2.1 2.3e-05 24.0 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat TGF_beta PF00019.15 CDI82431.1 - 0.0052 17.0 1.8 0.018 15.2 1.2 1.9 1 0 0 1 1 1 1 Transforming growth factor beta like domain Apt1 PF10351.4 CDI82431.1 - 0.21 10.3 6.6 1.3 7.8 4.7 2.0 1 1 0 1 1 1 0 Golgi-body localisation protein domain Spuma_A9PTase PF03539.9 CDI82432.1 - 0.00075 19.4 2.5 0.00075 19.4 1.8 2.1 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) DUF3357 PF11837.3 CDI82432.1 - 0.44 10.4 0.1 0.44 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) LMBR1 PF04791.11 CDI82433.1 - 0.0044 15.6 0.3 1 7.8 0.0 2.2 1 1 0 2 2 2 1 LMBR1-like membrane protein DUF3801 PF12687.2 CDI82433.1 - 0.42 10.1 25.3 0.051 13.1 1.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3801) OmpH PF03938.9 CDI82433.1 - 0.64 9.9 57.1 3.2 7.6 27.1 3.3 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) SOBP PF15279.1 CDI82433.1 - 1 9.6 29.9 2.2 8.5 2.4 3.1 3 0 0 3 3 3 0 Sine oculis-binding protein Utp11 PF03998.8 CDI82433.1 - 1.9 8.2 31.9 0.73 9.6 7.5 3.1 3 0 0 3 3 3 0 Utp11 protein Neur_chan_memb PF02932.11 CDI82433.1 - 4.7 7.0 28.9 0.29 10.9 4.9 3.2 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PIP5K PF01504.13 CDI82434.1 - 2.7e-22 79.0 0.0 3.1e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase AAA_2 PF07724.9 CDI82435.1 - 4.1e-16 59.3 0.0 8.9e-16 58.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CDI82435.1 - 0.00012 22.0 0.1 0.00031 20.7 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain Torsin PF06309.6 CDI82435.1 - 0.00018 21.3 0.0 0.00035 20.4 0.0 1.4 1 0 0 1 1 1 1 Torsin Zeta_toxin PF06414.7 CDI82435.1 - 0.0002 20.5 0.2 0.00074 18.6 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.1 CDI82435.1 - 0.00059 20.1 0.3 0.0023 18.2 0.0 2.1 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.1 CDI82435.1 - 0.00084 20.1 0.2 0.0041 17.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 CDI82435.1 - 0.0013 18.8 0.0 0.0029 17.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CDI82435.1 - 0.0021 17.5 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.1 CDI82435.1 - 0.0041 17.2 0.1 0.12 12.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain DNA_pol3_delta2 PF13177.1 CDI82435.1 - 0.0079 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Bac_DnaA PF00308.13 CDI82435.1 - 0.0095 15.6 0.1 0.2 11.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein IstB_IS21 PF01695.12 CDI82435.1 - 0.015 14.6 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein MbeB_N PF04837.7 CDI82435.1 - 0.016 15.3 0.6 0.38 10.8 0.0 3.0 3 0 0 3 3 3 0 MbeB-like, N-term conserved region Alpha-E PF04168.7 CDI82435.1 - 0.02 14.3 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. DUF815 PF05673.8 CDI82435.1 - 0.024 13.5 0.1 0.048 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RuvB_N PF05496.7 CDI82435.1 - 0.029 13.3 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus ABC_tran PF00005.22 CDI82435.1 - 0.037 14.3 0.1 0.13 12.5 0.0 1.9 2 1 0 2 2 2 0 ABC transporter DUF258 PF03193.11 CDI82435.1 - 0.051 12.7 0.0 0.086 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Hpr_kinase_C PF07475.7 CDI82435.1 - 0.052 12.8 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_33 PF13671.1 CDI82435.1 - 0.064 13.1 0.0 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF3490 PF11995.3 CDI82435.1 - 0.071 12.6 0.2 0.31 10.5 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3490) AAA_28 PF13521.1 CDI82435.1 - 0.076 12.9 0.0 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Homeobox PF00046.24 CDI82435.1 - 0.078 12.6 0.1 0.29 10.8 0.1 2.0 1 0 0 1 1 1 0 Homeobox domain AAA_5 PF07728.9 CDI82435.1 - 0.085 12.5 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 CDI82435.1 - 0.089 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.4 CDI82435.1 - 0.092 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Brix PF04427.13 CDI82438.1 - 1.3e-22 80.3 0.2 2.4e-22 79.5 0.1 1.4 1 0 0 1 1 1 1 Brix domain SET PF00856.23 CDI82440.1 - 1.7e-08 34.9 0.0 2.6e-07 31.1 0.0 2.5 1 1 0 1 1 1 1 SET domain PGC7_Stella PF15549.1 CDI82440.1 - 0.29 11.0 3.6 0.56 10.1 0.6 2.4 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain Mon1 PF03164.9 CDI82441.1 - 7.1e-40 136.8 0.6 1.2e-37 129.4 0.4 2.0 2 0 0 2 2 2 2 Trafficking protein Mon1 Stimulus_sens_1 PF13756.1 CDI82443.1 - 0.18 12.1 8.7 2.3 8.6 0.5 3.3 2 1 1 3 3 3 0 Stimulus-sensing domain DUF3379 PF11859.3 CDI82443.1 - 0.31 10.1 5.2 0.065 12.4 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3379) DUF1003 PF06210.6 CDI82443.1 - 0.85 9.5 4.6 0.36 10.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) Pex14_N PF04695.8 CDI82450.1 - 9.8e-05 22.4 5.5 0.00013 22.0 3.8 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.9 CDI82450.1 - 0.0017 18.1 4.4 0.0019 18.0 3.0 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) BAF1_ABF1 PF04684.8 CDI82450.1 - 0.0028 16.5 14.6 0.0032 16.4 10.1 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor SAGA-Tad1 PF12767.2 CDI82450.1 - 0.0039 16.8 6.7 0.0046 16.6 4.6 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Ribosomal_S10 PF00338.17 CDI82450.1 - 0.011 15.5 1.2 0.078 12.8 1.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S10p/S20e SeqA PF03925.8 CDI82450.1 - 0.015 15.0 6.5 0.021 14.5 4.5 1.1 1 0 0 1 1 1 0 SeqA protein DDHD PF02862.12 CDI82450.1 - 0.019 14.8 2.2 0.023 14.4 1.5 1.1 1 0 0 1 1 1 0 DDHD domain Dynamin_N PF00350.18 CDI82450.1 - 0.035 13.9 1.5 0.044 13.5 1.1 1.2 1 0 0 1 1 1 0 Dynamin family OmpH PF03938.9 CDI82450.1 - 0.036 14.0 16.0 0.043 13.7 11.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) NMDAR2_C PF10565.4 CDI82450.1 - 0.049 12.3 4.3 0.061 12.0 3.0 1.0 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus DUF2407_C PF13373.1 CDI82450.1 - 0.079 12.8 2.3 0.15 11.9 1.6 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain FimP PF09766.4 CDI82450.1 - 0.09 11.8 11.1 0.12 11.4 7.7 1.1 1 0 0 1 1 1 0 Fms-interacting protein DUF1477 PF07346.6 CDI82450.1 - 0.1 12.6 1.4 0.15 12.1 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1477) AIF_C PF14721.1 CDI82450.1 - 0.11 12.7 2.3 0.15 12.2 1.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Paramyxo_ncap PF00973.14 CDI82450.1 - 0.12 10.9 3.8 0.14 10.8 2.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4638 PF15472.1 CDI82450.1 - 0.14 11.7 4.3 0.16 11.5 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) BORG_CEP PF14957.1 CDI82450.1 - 0.25 12.2 3.4 0.36 11.7 2.3 1.2 1 0 0 1 1 1 0 Cdc42 effector Band_3_cyto PF07565.8 CDI82450.1 - 0.25 10.8 4.8 0.33 10.4 3.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2547 PF10818.3 CDI82450.1 - 0.28 11.8 19.1 0.43 11.2 13.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2547) MDFI PF15316.1 CDI82450.1 - 0.45 10.4 3.7 0.57 10.1 2.6 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Med15 PF09606.5 CDI82450.1 - 0.66 8.1 27.4 0.77 7.8 19.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2967 PF11179.3 CDI82450.1 - 0.66 9.4 8.4 0.85 9.0 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Gag_spuma PF03276.9 CDI82450.1 - 0.97 7.6 15.5 1.2 7.4 10.7 1.1 1 0 0 1 1 1 0 Spumavirus gag protein PAT1 PF09770.4 CDI82450.1 - 1 7.4 18.8 1.2 7.2 13.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Totivirus_coat PF05518.6 CDI82450.1 - 2.3 5.9 6.9 2.7 5.7 4.8 1.0 1 0 0 1 1 1 0 Totivirus coat protein SIT PF15330.1 CDI82450.1 - 4 7.6 11.4 6.1 7.0 7.9 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT PP_kinase_N PF13089.1 CDI82450.1 - 4 7.5 8.3 6.8 6.8 5.7 1.3 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain DUF4557 PF15101.1 CDI82450.1 - 4.1 7.1 12.5 5.4 6.8 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF4106 PF13388.1 CDI82450.1 - 4.6 6.1 14.3 5.3 5.8 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Phage_Gp23 PF10669.4 CDI82450.1 - 6.3 6.9 7.3 11 6.2 5.1 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF4175 PF13779.1 CDI82450.1 - 6.4 4.3 22.9 8 4.0 15.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RRM_1 PF00076.17 CDI82451.1 - 1.3e-41 140.1 0.1 4.3e-16 58.2 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI82451.1 - 1.8e-32 111.1 0.0 1.2e-11 44.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI82451.1 - 3.2e-16 58.9 6.9 2e-07 30.7 0.1 4.2 4 1 1 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.21 CDI82451.1 - 1.8e-05 24.5 3.5 3.3e-05 23.6 2.4 1.5 1 0 0 1 1 1 1 WW domain Utp14 PF04615.8 CDI82451.1 - 4.1 5.4 49.2 0.3 9.1 23.0 2.1 2 0 0 2 2 2 0 Utp14 protein YgbB PF02542.11 CDI82452.1 - 4.6e-47 159.7 1.4 3e-42 144.0 0.8 2.2 2 0 0 2 2 2 2 YgbB family FAD-oxidase_C PF02913.14 CDI82452.1 - 0.29 10.4 8.2 0.3 10.3 2.9 2.2 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain RNA_pol PF00940.14 CDI82453.1 - 3.4e-130 434.1 0.0 7.4e-130 433.0 0.0 1.6 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 CDI82453.1 - 2.9e-21 76.0 0.4 8.4e-13 48.2 0.0 5.6 4 1 1 5 5 5 3 DNA-directed RNA polymerase N-terminal Cluap1 PF10234.4 CDI82456.1 - 0.013 14.7 12.3 0.072 12.2 8.5 2.1 1 1 0 1 1 1 0 Clusterin-associated protein-1 AAA_13 PF13166.1 CDI82456.1 - 0.58 8.5 6.7 0.19 10.1 2.4 1.6 1 1 1 2 2 2 0 AAA domain Med9 PF07544.8 CDI82456.1 - 0.62 9.8 7.2 7.9 6.2 0.1 3.2 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 RMP PF14996.1 CDI82456.1 - 0.91 9.4 3.8 0.46 10.3 0.4 2.1 1 1 2 3 3 3 0 Retinal Maintenance Bap31 PF05529.7 CDI82456.1 - 6.2 6.2 9.0 0.41 10.0 0.3 2.5 3 0 0 3 3 3 0 B-cell receptor-associated protein 31-like DUF812 PF05667.6 CDI82456.1 - 6.5 5.1 20.0 11 4.3 13.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) CAF-1_p150 PF11600.3 CDI82456.1 - 6.9 5.9 12.0 16 4.8 8.3 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DEAD PF00270.24 CDI82457.1 - 1.5e-33 115.7 0.0 2.4e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI82457.1 - 1.6e-23 82.3 0.0 3.8e-23 81.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI82457.1 - 8.7e-05 22.4 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 CDI82457.1 - 0.025 14.3 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_22 PF13401.1 CDI82457.1 - 0.042 13.9 0.0 2.8 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF2175 PF09943.4 CDI82459.1 - 0.067 13.2 0.6 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) DUF2116 PF09889.4 CDI82459.1 - 0.076 12.8 2.0 0.61 9.9 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DiS_P_DiS PF06750.8 CDI82459.1 - 0.33 10.7 1.6 13 5.6 0.2 2.0 1 1 1 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Cpn60_TCP1 PF00118.19 CDI82461.1 - 1.5e-38 132.7 0.0 1.7e-38 132.4 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NAD_Gly3P_dh_C PF07479.9 CDI82461.1 - 0.034 13.8 0.0 0.09 12.4 0.0 1.7 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus PilI PF10623.4 CDI82462.1 - 0.1 12.5 0.5 1.2 9.1 0.4 2.0 1 1 0 1 1 1 0 Plasmid conjugative transfer protein PilI ketoacyl-synt PF00109.21 CDI82466.1 - 6.2e-133 441.9 0.2 1.4e-65 221.2 0.1 2.4 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CDI82466.1 - 4.9e-58 194.1 1.1 2e-35 121.2 0.1 2.6 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 CDI82466.1 - 1.9e-11 44.0 0.0 5.3e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.18 CDI82466.1 - 6.9e-05 21.9 5.1 0.0018 17.3 0.1 3.2 3 0 0 3 3 3 1 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CDI82466.1 - 0.058 13.0 6.5 0.079 12.6 0.3 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF503 PF04456.7 CDI82466.1 - 0.21 11.1 0.0 0.55 9.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF503) EF-hand_8 PF13833.1 CDI82467.1 - 5.9e-12 45.0 0.2 1e-11 44.2 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 CDI82467.1 - 1.6e-11 44.1 0.4 2.7e-11 43.4 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDI82467.1 - 5.3e-10 37.8 0.7 4.7e-05 22.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 CDI82467.1 - 3.4e-07 29.5 3.8 0.0065 16.2 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 CDI82467.1 - 0.0014 17.9 0.0 0.0093 15.2 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.1 CDI82467.1 - 0.024 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain HEAT PF02985.17 CDI82468.1 - 0.015 15.3 7.4 0.88 9.8 0.1 5.8 5 0 0 5 5 5 0 HEAT repeat NOB1_Zn_bind PF08772.6 CDI82469.1 - 1.8e-18 66.1 0.3 3.1e-18 65.3 0.2 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.6 CDI82469.1 - 0.044 13.2 0.9 5.3 6.6 0.1 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain OrfB_Zn_ribbon PF07282.6 CDI82469.1 - 0.054 13.1 1.1 0.11 12.1 0.7 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.1 CDI82469.1 - 0.057 12.6 0.1 0.12 11.5 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain DUF177 PF02620.12 CDI82469.1 - 0.11 12.5 5.5 0.23 11.5 3.8 1.5 1 0 0 1 1 1 0 Uncharacterized ACR, COG1399 Nudix_N_2 PF14803.1 CDI82469.1 - 0.2 11.3 1.4 3.5 7.3 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal RRN3 PF05327.6 CDI82469.1 - 7.9 4.4 6.5 12 3.9 4.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Dus PF01207.12 CDI82470.1 - 1.1e-37 129.6 0.0 4.2e-31 107.9 0.0 2.5 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) FleQ PF06490.6 CDI82470.1 - 0.039 14.0 0.1 0.3 11.2 0.0 2.4 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ zf-CCCH PF00642.19 CDI82470.1 - 0.071 12.8 10.3 0.38 10.4 7.1 2.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ApoLp-III PF07464.6 CDI82471.1 - 8.5e-05 22.6 0.2 0.00021 21.3 0.2 1.7 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) 3-alpha PF03475.9 CDI82471.1 - 0.096 12.4 2.1 9.7 6.0 0.1 2.9 2 0 0 2 2 2 0 3-alpha domain CorA PF01544.13 CDI82471.1 - 0.31 10.0 2.5 0.85 8.5 0.4 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein HA2 PF04408.18 CDI82474.1 - 3.5e-12 46.2 0.5 1e-11 44.7 0.1 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDI82474.1 - 0.0001 22.1 0.1 0.00019 21.2 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Ribosomal_60s PF00428.14 CDI82474.1 - 0.047 14.0 4.3 0.11 12.8 3.0 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein PH PF00169.24 CDI82477.1 - 0.043 14.0 0.4 0.069 13.3 0.3 1.5 1 1 0 1 1 1 0 PH domain Myosin_TH1 PF06017.8 CDI82477.1 - 0.044 13.0 0.0 0.3 10.3 0.0 2.0 2 0 0 2 2 2 0 Myosin tail RAP1 PF07218.6 CDI82477.1 - 0.25 9.3 7.0 0.28 9.2 4.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Kinase-like PF14531.1 CDI82478.1 - 5.4e-06 25.5 0.0 1.1e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase PF00069.20 CDI82478.1 - 5.9e-06 25.6 0.0 8.9e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82478.1 - 0.00017 20.7 0.0 0.0003 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APC10 PF03256.11 CDI82481.1 - 2.7e-08 33.6 0.0 3.1e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) BNR PF02012.15 CDI82483.1 - 0.00097 18.6 1.5 0.46 10.5 0.0 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat Ribosomal_60s PF00428.14 CDI82483.1 - 0.017 15.4 8.5 0.028 14.8 5.9 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein SprA-related PF12118.3 CDI82493.1 - 0.026 13.8 39.4 0.033 13.5 27.3 1.1 1 0 0 1 1 1 0 SprA-related family Apt1 PF10351.4 CDI82493.1 - 0.085 11.7 21.4 0.11 11.3 14.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AAA_23 PF13476.1 CDI82493.1 - 0.9 9.8 21.1 1.2 9.4 14.6 1.1 1 0 0 1 1 1 0 AAA domain X PF00739.14 CDI82493.1 - 6 6.7 6.1 9.2 6.1 4.2 1.5 1 1 0 1 1 1 0 Trans-activation protein X SSP160 PF06933.6 CDI82493.1 - 7 4.4 22.7 11 3.7 15.8 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SOBP PF15279.1 CDI82493.1 - 7.7 6.8 25.9 8.8 6.6 18.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein RNA_pol_Rpb2_1 PF04563.10 CDI82495.1 - 7.9e-26 90.2 0.0 2.1e-25 88.8 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase beta subunit SR-25 PF10500.4 CDI82497.1 - 0.03 13.7 22.0 0.04 13.3 15.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ICAP-1_inte_bdg PF10480.4 CDI82497.1 - 0.083 12.6 2.9 0.12 12.1 2.0 1.5 1 0 0 1 1 1 0 Beta-1 integrin binding protein Host_attach PF10116.4 CDI82497.1 - 0.085 13.0 3.0 0.12 12.5 2.1 1.2 1 0 0 1 1 1 0 Protein required for attachment to host cells Rubella_Capsid PF05750.6 CDI82497.1 - 0.12 11.7 6.0 0.18 11.1 4.1 1.3 1 0 0 1 1 1 0 Rubella capsid protein DUF755 PF05501.6 CDI82497.1 - 0.16 12.0 19.3 0.2 11.6 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) BLVR PF06375.6 CDI82497.1 - 0.21 11.4 2.3 0.27 11.0 1.6 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Rox3 PF08633.5 CDI82497.1 - 0.64 10.3 4.0 0.8 9.9 2.8 1.1 1 0 0 1 1 1 0 Rox3 mediator complex subunit Macoilin PF09726.4 CDI82497.1 - 0.65 8.2 5.7 0.67 8.1 3.9 1.0 1 0 0 1 1 1 0 Transmembrane protein Dehydrin PF00257.14 CDI82497.1 - 1.1 9.6 5.3 1.4 9.2 3.7 1.2 1 0 0 1 1 1 0 Dehydrin Pox_A12 PF04651.8 CDI82497.1 - 1.8 8.6 7.8 2.3 8.3 5.4 1.1 1 0 0 1 1 1 0 Poxvirus A12 protein TFIIF_alpha PF05793.7 CDI82497.1 - 2.5 6.3 7.0 3 6.1 4.9 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_viral_N PF00242.12 CDI82497.1 - 2.6 7.0 5.3 2.6 6.9 3.7 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF1180 PF06679.7 CDI82497.1 - 4.2 7.2 9.4 1.8 8.4 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) TSA PF03249.8 CDI82499.1 - 2.4 6.5 7.1 3.6 5.9 4.9 1.2 1 0 0 1 1 1 0 Type specific antigen ATP-synt_D PF01813.12 CDI82505.1 - 1.9e-40 138.5 0.4 2.4e-40 138.2 0.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit D FimP PF09766.4 CDI82507.1 - 0.0036 16.4 20.9 0.0036 16.4 14.5 1.1 1 0 0 1 1 1 1 Fms-interacting protein Pex14_N PF04695.8 CDI82507.1 - 0.0057 16.7 15.5 0.0058 16.6 10.7 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DDRGK PF09756.4 CDI82507.1 - 0.01 15.2 15.7 0.011 15.1 10.9 1.1 1 0 0 1 1 1 0 DDRGK domain Spore_coat_CotO PF14153.1 CDI82507.1 - 0.042 13.2 15.1 0.039 13.3 10.4 1.1 1 0 0 1 1 1 0 Spore coat protein CotO SpoIIP PF07454.6 CDI82507.1 - 0.12 11.4 6.7 0.11 11.6 4.6 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2370 PF10176.4 CDI82507.1 - 0.14 11.4 5.3 0.14 11.4 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Band_3_cyto PF07565.8 CDI82507.1 - 0.16 11.4 11.3 0.17 11.3 7.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3306 PF11748.3 CDI82507.1 - 0.21 12.2 11.5 0.21 12.2 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) FlaG PF03646.10 CDI82507.1 - 0.24 11.5 17.8 0.3 11.2 12.3 1.4 1 0 0 1 1 1 0 FlaG protein RED_N PF07808.8 CDI82507.1 - 0.26 10.4 18.6 0.24 10.5 12.9 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF913 PF06025.7 CDI82507.1 - 0.35 9.5 7.0 0.37 9.4 4.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Gti1_Pac2 PF09729.4 CDI82507.1 - 0.35 10.7 8.1 0.36 10.7 5.6 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1764 PF08576.5 CDI82507.1 - 0.46 11.2 14.0 0.56 11.0 9.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3121 PF11319.3 CDI82507.1 - 0.47 9.9 8.7 0.46 9.9 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3121) DUF3464 PF11947.3 CDI82507.1 - 0.52 9.7 9.9 0.6 9.5 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Serinc PF03348.10 CDI82507.1 - 0.6 8.7 10.8 0.55 8.8 7.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2946 PF11162.3 CDI82507.1 - 0.62 10.2 6.2 0.78 9.9 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) Ctr PF04145.10 CDI82507.1 - 0.65 10.0 5.8 0.74 9.8 4.1 1.3 1 0 0 1 1 1 0 Ctr copper transporter family GOLD_2 PF13897.1 CDI82507.1 - 0.77 9.9 3.0 0.75 10.0 2.1 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Zip PF02535.17 CDI82507.1 - 0.77 8.7 5.6 0.85 8.5 3.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.1 CDI82507.1 - 0.77 9.4 6.5 0.85 9.2 4.5 1.3 1 0 0 1 1 1 0 FAM176 family Peroxin-13_N PF04088.8 CDI82507.1 - 0.88 9.5 6.8 1.1 9.2 4.7 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Dala_Dala_lig_N PF01820.16 CDI82507.1 - 0.9 9.8 5.7 0.92 9.8 4.0 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus SAGA-Tad1 PF12767.2 CDI82507.1 - 0.91 9.1 15.5 0.96 9.0 10.7 1.0 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Kei1 PF08552.6 CDI82507.1 - 1 9.0 7.9 1.1 8.9 5.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CDC45 PF02724.9 CDI82507.1 - 1 7.3 10.3 0.96 7.3 7.2 1.0 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.1 CDI82507.1 - 1 9.7 8.7 1.7 9.0 6.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rho_GDI PF02115.12 CDI82507.1 - 1.1 8.6 12.8 1.4 8.3 8.9 1.2 1 1 0 1 1 1 0 RHO protein GDP dissociation inhibitor DUF775 PF05603.7 CDI82507.1 - 1.2 8.5 14.6 1.4 8.3 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) SpoVR PF04293.8 CDI82507.1 - 1.2 7.3 10.8 1.1 7.5 7.5 1.1 1 0 0 1 1 1 0 SpoVR like protein EIIBC-GUT_N PF03612.9 CDI82507.1 - 1.3 8.5 9.4 1.3 8.5 6.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF853 PF05872.7 CDI82507.1 - 1.5 7.1 9.3 1.3 7.2 6.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF3408 PF11888.3 CDI82507.1 - 1.5 8.7 10.9 1.8 8.5 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) BRF1 PF07741.8 CDI82507.1 - 1.5 9.0 11.7 1.8 8.8 8.1 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF4220 PF13968.1 CDI82507.1 - 1.5 7.8 6.6 1.4 7.8 4.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Peptidase_S49_N PF08496.5 CDI82507.1 - 1.5 8.5 12.8 1.7 8.4 8.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FAM60A PF15396.1 CDI82507.1 - 1.6 8.4 8.3 1.6 8.4 5.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CRF1 PF10380.4 CDI82507.1 - 1.9 8.8 10.1 1.9 8.8 7.0 1.1 1 0 0 1 1 1 0 Transcription factor CRF1 Afi1 PF07792.7 CDI82507.1 - 1.9 8.5 12.5 2 8.4 8.7 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Tim54 PF11711.3 CDI82507.1 - 1.9 6.9 8.9 1.9 7.0 6.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TFIIA PF03153.8 CDI82507.1 - 2.3 8.0 25.4 2.2 8.0 17.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DHHW PF14286.1 CDI82507.1 - 2.5 7.3 9.5 2.4 7.4 6.6 1.0 1 0 0 1 1 1 0 DHHW protein Ycf1 PF05758.7 CDI82507.1 - 2.5 5.6 13.1 2.3 5.8 9.0 1.0 1 0 0 1 1 1 0 Ycf1 DUF2813 PF11398.3 CDI82507.1 - 2.7 6.9 12.6 2.9 6.8 8.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) SeqA PF03925.8 CDI82507.1 - 2.8 7.5 11.5 2.8 7.5 8.0 1.1 1 0 0 1 1 1 0 SeqA protein Dynamin_N PF00350.18 CDI82507.1 - 2.9 7.7 7.2 2.8 7.7 5.0 1.1 1 0 0 1 1 1 0 Dynamin family Suf PF05843.9 CDI82507.1 - 3.1 7.4 20.3 3.4 7.2 14.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Bul1_N PF04425.7 CDI82507.1 - 3.2 6.2 11.4 3.3 6.1 7.9 1.1 1 0 0 1 1 1 0 Bul1 N terminus FliP PF00813.15 CDI82507.1 - 3.2 7.3 5.7 3.3 7.3 3.9 1.1 1 0 0 1 1 1 0 FliP family F-protein PF00469.15 CDI82507.1 - 3.3 7.0 14.7 3.7 6.8 10.2 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Ndc1_Nup PF09531.5 CDI82507.1 - 3.6 5.8 10.2 3.7 5.8 7.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Raftlin PF15250.1 CDI82507.1 - 3.7 5.9 13.2 3.8 5.9 9.2 1.0 1 0 0 1 1 1 0 Raftlin Trypan_glycop_C PF10659.4 CDI82507.1 - 3.8 7.8 13.2 5.7 7.2 9.1 1.3 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain Corona_NS3b PF03053.9 CDI82507.1 - 4.1 6.8 5.3 6.2 6.2 3.6 1.3 1 1 0 1 1 1 0 ORF3b coronavirus protein DUF605 PF04652.11 CDI82507.1 - 4.3 6.6 19.8 4.3 6.6 13.7 1.0 1 0 0 1 1 1 0 Vta1 like Pox_Ag35 PF03286.9 CDI82507.1 - 4.6 6.7 10.5 5.4 6.4 7.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Neur_chan_memb PF02932.11 CDI82507.1 - 5 6.9 7.4 5.4 6.8 5.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spore_YhcN_YlaJ PF09580.5 CDI82507.1 - 5.1 7.1 13.5 5 7.1 9.4 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RR_TM4-6 PF06459.7 CDI82507.1 - 5.6 6.7 14.3 6.3 6.5 9.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MDFI PF15316.1 CDI82507.1 - 5.7 6.9 9.1 6.5 6.7 6.3 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Sec62 PF03839.11 CDI82507.1 - 6.1 6.1 15.1 7.3 5.9 10.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 eIF-3_zeta PF05091.7 CDI82507.1 - 7 5.1 18.6 6.7 5.2 12.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF822 PF05687.8 CDI82507.1 - 7.6 6.8 8.2 7.9 6.8 5.7 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF822) Rtf2 PF04641.7 CDI82507.1 - 8 5.5 14.0 9.1 5.3 9.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4557 PF15101.1 CDI82507.1 - 8.1 6.2 28.3 8.6 6.1 19.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) IncA PF04156.9 CDI82507.1 - 8.1 5.9 25.1 8 6.0 17.4 1.1 1 0 0 1 1 1 0 IncA protein OATP PF03137.15 CDI82507.1 - 8.7 4.2 14.1 9.7 4.1 9.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3260 PF11658.3 CDI82507.1 - 9 4.3 12.3 8.6 4.3 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) DUF2201_N PF13203.1 CDI82507.1 - 9.1 5.3 14.6 9.7 5.2 10.1 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Paramyxo_ncap PF00973.14 CDI82507.1 - 9.7 4.7 10.4 9.4 4.7 7.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein BTV_NS2 PF04514.7 CDI82507.1 - 9.8 4.9 11.9 11 4.8 8.3 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 LRV_FeS PF05484.6 CDI82511.1 - 0.028 13.9 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 LRV protein FeS4 cluster Hid1 PF12722.2 CDI82511.1 - 0.47 8.0 22.5 0.6 7.7 15.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.7 CDI82511.1 - 2 6.2 10.7 2.3 6.0 7.4 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RING_2 PF13639.1 CDI82514.1 - 0.068 13.0 2.5 0.13 12.0 1.8 1.5 1 0 0 1 1 1 0 Ring finger domain DDRGK PF09756.4 CDI82523.1 - 0.3 10.4 17.3 0.32 10.3 12.0 1.1 1 0 0 1 1 1 0 DDRGK domain AAA_11 PF13086.1 CDI82523.1 - 0.4 10.2 16.9 0.47 9.9 11.7 1.1 1 0 0 1 1 1 0 AAA domain Serinc PF03348.10 CDI82523.1 - 0.42 9.2 13.8 0.48 9.0 9.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4557 PF15101.1 CDI82523.1 - 0.55 10.0 28.2 0.61 9.8 19.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Bud13 PF09736.4 CDI82523.1 - 0.57 10.4 16.8 0.64 10.2 11.7 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex BAF1_ABF1 PF04684.8 CDI82523.1 - 1.4 7.7 33.1 1.6 7.4 22.9 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2217 PF10265.4 CDI82523.1 - 1.4 7.5 27.3 1.6 7.4 18.9 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF4175 PF13779.1 CDI82523.1 - 1.5 6.3 41.1 1.6 6.2 28.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RR_TM4-6 PF06459.7 CDI82523.1 - 1.7 8.4 16.8 1.7 8.4 11.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med15 PF09606.5 CDI82523.1 - 2 6.5 49.1 2.1 6.4 34.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4407 PF14362.1 CDI82523.1 - 2.4 7.0 15.9 2.4 7.0 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Asp-B-Hydro_N PF05279.6 CDI82523.1 - 2.7 7.7 10.3 2.6 7.8 7.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Endonuc_Holl PF10107.4 CDI82523.1 - 2.7 7.6 15.9 3.5 7.2 11.0 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Glu_synthase PF01645.12 CDI82523.1 - 3 6.6 10.2 3.4 6.5 7.1 1.0 1 0 0 1 1 1 0 Conserved region in glutamate synthase Cwf_Cwc_15 PF04889.7 CDI82523.1 - 3.5 7.2 23.0 4.2 7.0 15.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Peptidase_S15 PF02129.13 CDI82523.1 - 3.6 6.9 11.2 3.7 6.8 7.7 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SAGA-Tad1 PF12767.2 CDI82523.1 - 3.7 7.1 25.8 5.1 6.6 17.9 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Glyco_transf_15 PF01793.11 CDI82523.1 - 3.9 6.3 14.3 4.2 6.2 9.9 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase FimP PF09766.4 CDI82523.1 - 4 6.4 29.2 5.1 6.0 20.2 1.2 1 0 0 1 1 1 0 Fms-interacting protein eIF-3_zeta PF05091.7 CDI82523.1 - 4.1 5.9 20.3 4.2 5.8 14.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.4 CDI82523.1 - 4.6 5.3 41.6 4.6 5.3 28.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FemAB PF02388.11 CDI82523.1 - 4.7 5.7 13.7 4.9 5.7 9.5 1.0 1 0 0 1 1 1 0 FemAB family TIMELESS PF04821.9 CDI82523.1 - 5.2 6.2 14.1 6.8 5.8 9.8 1.2 1 0 0 1 1 1 0 Timeless protein DUF853 PF05872.7 CDI82523.1 - 5.3 5.2 13.9 5.7 5.1 9.6 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF4199 PF13858.1 CDI82523.1 - 6.9 6.5 8.4 7.9 6.3 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF4220 PF13968.1 CDI82523.1 - 8.1 5.4 10.6 8.3 5.3 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Dehalogenase PF13486.1 CDI82523.1 - 8.3 5.7 12.3 9.1 5.6 8.5 1.0 1 0 0 1 1 1 0 Reductive dehalogenase subunit SpoIIIAH PF12685.2 CDI82523.1 - 9.9 5.6 19.7 12 5.3 13.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Dynein_heavy PF03028.10 CDI82524.1 - 0.023 12.7 0.0 1 7.3 0.0 2.0 2 0 0 2 2 2 0 Dynein heavy chain and region D6 of dynein motor Macoilin PF09726.4 CDI82524.1 - 0.38 8.9 6.7 0.43 8.8 4.6 1.1 1 0 0 1 1 1 0 Transmembrane protein VirionAssem_T7 PF11653.3 CDI82524.1 - 1.9 9.2 7.5 3.4 8.4 5.2 1.5 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein Shadoo PF14999.1 CDI82524.1 - 9.8 6.0 15.3 3.9 7.3 0.5 2.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Laminin_II PF06009.7 CDI82528.1 - 0.051 13.3 0.1 0.061 13.0 0.1 1.1 1 0 0 1 1 1 0 Laminin Domain II DUF1973 PF09315.6 CDI82528.1 - 0.068 12.5 0.0 0.077 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1973) E1_dh PF00676.15 CDI82531.1 - 1.9e-32 112.1 0.0 4e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.19 CDI82531.1 - 1.1e-30 106.4 0.0 1.9e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain AdoMetDC_leader PF08132.6 CDI82533.1 - 0.11 12.3 1.8 0.24 11.3 1.3 1.4 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide Guanylate_cyc PF00211.15 CDI82534.1 - 2.1e-50 170.6 0.0 1.5e-30 105.8 0.0 3.9 2 2 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain E1-E2_ATPase PF00122.15 CDI82534.1 - 0.0002 20.4 0.0 0.00062 18.8 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase S6PP PF05116.8 CDI82534.1 - 0.22 10.7 0.0 2.1 7.5 0.0 2.1 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Utp11 PF03998.8 CDI82535.1 - 1.6 8.4 59.3 0.45 10.3 13.5 2.1 2 0 0 2 2 2 0 Utp11 protein DUF3492 PF11997.3 CDI82535.1 - 8.8 5.7 30.8 2.2 7.7 7.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) TT_ORF1 PF02956.9 CDI82535.1 - 9.2 4.5 33.6 2.8 6.3 7.3 2.1 2 0 0 2 2 2 0 TT viral orf 1 rve PF00665.21 CDI82537.1 - 5.4e-07 29.7 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 CDI82537.1 - 0.0096 15.3 0.2 0.016 14.6 0.2 1.3 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.21 CDI82540.1 - 3e-14 53.1 0.0 5.6e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.19 CDI82540.1 - 5.1e-05 22.8 0.3 0.00011 21.7 0.2 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC_2 PF13696.1 CDI82540.1 - 0.016 14.7 0.6 0.037 13.5 0.4 1.7 1 0 0 1 1 1 0 Zinc knuckle SEN1_N PF12726.2 CDI82541.1 - 0.02 12.9 0.1 0.025 12.6 0.0 1.2 1 0 0 1 1 1 0 SEN1 N terminal Pkinase PF00069.20 CDI82543.1 - 1.5e-16 60.3 0.0 3e-16 59.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82543.1 - 0.037 13.1 0.0 0.17 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein tyrosine kinase SoxE PF06525.6 CDI82543.1 - 1.5 8.0 9.3 4.2 6.5 1.8 2.3 2 0 0 2 2 2 0 Sulfocyanin (SoxE) EzrA PF06160.7 CDI82544.1 - 0.012 13.8 1.3 0.038 12.1 1.1 1.6 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Lysine_decarbox PF03641.9 CDI82548.1 - 5.6e-25 87.6 0.0 1.1e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase Trm112p PF03966.11 CDI82549.1 - 4.5e-15 55.7 0.1 6.5e-15 55.2 0.1 1.2 1 0 0 1 1 1 1 Trm112p-like protein zf-dskA_traR PF01258.12 CDI82549.1 - 0.08 12.7 0.2 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger NADH-G_4Fe-4S_3 PF10588.4 CDI82549.1 - 0.087 12.0 0.0 0.22 10.8 0.0 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF159 PF02586.9 CDI82550.1 - 1.1e-29 103.5 0.0 1.1e-29 103.5 0.0 2.5 2 1 0 2 2 2 1 Uncharacterised ACR, COG2135 PLRV_ORF5 PF01690.12 CDI82550.1 - 1.4 7.9 21.9 2.7 7.0 15.2 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Macoilin PF09726.4 CDI82550.1 - 1.7 6.8 28.9 1.4 7.1 13.7 2.3 2 0 0 2 2 2 0 Transmembrane protein Ycf1 PF05758.7 CDI82550.1 - 4.9 4.7 13.1 7.5 4.1 9.1 1.3 1 0 0 1 1 1 0 Ycf1 Herpes_env PF01673.13 CDI82550.1 - 8.8 4.7 20.6 15 3.9 14.3 1.3 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Med15 PF09606.5 CDI82552.1 - 3.6 5.6 11.8 4.1 5.4 8.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CDK2AP PF09806.4 CDI82552.1 - 8.2 6.6 8.1 0.22 11.7 0.8 1.7 1 1 1 2 2 2 0 Cyclin-dependent kinase 2-associated protein UCH PF00443.24 CDI82553.1 - 7.3e-18 64.6 0.0 1.2e-12 47.5 0.0 2.4 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDI82553.1 - 0.0048 16.3 0.3 1.6 8.1 0.0 3.4 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase KOG2701 PF09762.4 CDI82553.1 - 0.44 10.6 5.2 0.83 9.6 3.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) Sporozoite_P67 PF05642.6 CDI82554.1 - 0.00093 17.1 2.3 0.00093 17.1 1.6 4.5 4 2 0 4 4 4 1 Sporozoite P67 surface antigen Kinase-like PF14531.1 CDI82558.1 - 1.4e-07 30.8 0.0 1.8e-06 27.1 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Pkinase PF00069.20 CDI82558.1 - 4.6e-06 25.9 0.0 6.3e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82558.1 - 0.0021 17.1 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PAN_4 PF14295.1 CDI82560.1 - 2e-27 94.6 17.6 5e-10 38.9 1.3 3.5 3 0 0 3 3 3 3 PAN domain PAN_1 PF00024.21 CDI82560.1 - 1.9e-22 78.7 11.6 2.5e-07 30.3 0.0 3.2 3 0 0 3 3 3 3 PAN domain PAN_3 PF08277.7 CDI82560.1 - 0.00027 20.4 6.4 0.11 12.1 0.1 3.3 3 0 0 3 3 3 2 PAN-like domain PAN_2 PF08276.6 CDI82560.1 - 0.015 15.1 13.5 0.2 11.5 0.3 3.3 3 0 0 3 3 3 0 PAN-like domain LRR_4 PF12799.2 CDI82561.1 - 3.8e-19 67.8 6.6 3.5e-11 42.4 1.1 3.8 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 CDI82561.1 - 1.7e-10 39.8 13.4 0.019 14.9 0.0 5.5 4 2 2 6 6 6 3 Leucine Rich repeat LRR_9 PF14580.1 CDI82561.1 - 8.9e-09 35.1 7.1 0.00015 21.3 0.5 2.4 1 1 2 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.1 CDI82561.1 - 1.3e-08 34.4 9.2 0.00038 20.1 0.5 3.0 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 CDI82561.1 - 6e-07 28.6 9.9 0.065 13.2 0.5 5.5 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 CDI82561.1 - 5.4e-06 25.7 10.2 2.3 8.8 0.2 5.8 6 0 0 6 6 6 2 Leucine rich repeat DUF2811 PF10929.3 CDI82561.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) Pkinase PF00069.20 CDI82566.1 - 1.5e-48 165.2 0.0 1.7e-36 125.7 0.0 6.6 9 0 0 9 9 9 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82566.1 - 1.7e-31 109.2 0.0 1.7e-31 109.2 0.0 5.6 5 1 0 5 5 5 1 Protein tyrosine kinase Spt20 PF12090.3 CDI82566.1 - 0.01 15.2 0.0 0.01 15.2 0.0 15.8 11 5 1 12 12 12 0 Spt20 family OB_NTP_bind PF07717.11 CDI82567.1 - 2.3e-29 101.5 0.0 8.7e-29 99.6 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CDI82567.1 - 2.8e-29 101.1 0.0 7.1e-29 99.8 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CDI82567.1 - 7.9e-08 32.0 0.0 2.4e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.18 CDI82567.1 - 3.8e-07 30.1 0.0 9.3e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.24 CDI82567.1 - 7.7e-06 25.5 0.1 2.1e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDI82567.1 - 9.6e-06 25.7 0.0 2.7e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 CDI82567.1 - 0.00073 18.5 0.3 0.0025 16.7 0.1 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.1 CDI82567.1 - 0.0041 16.8 0.1 0.015 15.0 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain Tmemb_cc2 PF10267.4 CDI82567.1 - 0.0069 15.0 9.9 0.012 14.1 6.9 1.4 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein PhoH PF02562.11 CDI82567.1 - 0.021 14.0 0.1 0.076 12.2 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_10 PF12846.2 CDI82567.1 - 0.042 13.2 0.0 3 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain DAP3 PF10236.4 CDI82567.1 - 0.07 12.0 0.0 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.17 CDI82567.1 - 0.098 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.1 CDI82567.1 - 0.2 11.5 1.1 1.2 9.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain Macoilin PF09726.4 CDI82567.1 - 0.54 8.4 13.5 1.1 7.5 9.4 1.5 1 0 0 1 1 1 0 Transmembrane protein SUI1 PF01253.17 CDI82568.1 - 5.1e-30 103.1 0.7 6.7e-30 102.7 0.5 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 RNase_PH PF01138.16 CDI82569.1 - 1.8e-07 31.5 0.0 3e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Trp_oprn_chp PF09534.5 CDI82570.1 - 3.5 7.1 12.5 0.77 9.3 3.6 2.6 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Optomotor-blind PF11078.3 CDI82572.1 - 0.053 13.8 0.8 0.11 12.8 0.6 1.5 1 0 0 1 1 1 0 Optomotor-blind protein N-terminal region Ribosomal_L37ae PF01780.14 CDI82576.1 - 1.7e-31 107.9 10.2 1.7e-15 56.6 1.2 2.1 1 1 1 2 2 2 2 Ribosomal L37ae protein family A2L_zn_ribbon PF08792.5 CDI82576.1 - 0.0079 15.6 2.5 0.28 10.6 0.1 2.5 2 0 0 2 2 2 1 A2L zinc ribbon domain Elf1 PF05129.8 CDI82576.1 - 0.0094 15.6 6.2 2.2 8.0 4.3 2.2 1 1 0 1 1 1 1 Transcription elongation factor Elf1 like zf-Di19 PF05605.7 CDI82576.1 - 0.024 14.7 2.0 0.058 13.5 1.4 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 CDI82576.1 - 0.035 14.4 0.7 0.51 10.7 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-TFIIB PF13453.1 CDI82576.1 - 0.34 10.1 3.0 13 5.0 0.0 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger Rep_fac-A_C PF08646.5 CDI82576.1 - 0.57 9.8 4.0 11 5.6 0.4 2.2 1 1 1 2 2 2 0 Replication factor-A C terminal domain zf-MIZ PF02891.15 CDI82576.1 - 0.71 9.4 6.2 1.2 8.6 4.2 1.5 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Zn_Tnp_IS1595 PF12760.2 CDI82576.1 - 7.8 6.3 9.2 4.1e+02 0.9 6.4 2.3 1 1 0 1 1 1 0 Transposase zinc-ribbon domain MIP-T3 PF10243.4 CDI82580.1 - 0.013 13.9 61.2 0.016 13.7 42.4 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PAT1 PF09770.4 CDI82580.1 - 0.36 9.0 100.6 0.44 8.7 69.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PLRV_ORF5 PF01690.12 CDI82580.1 - 0.55 9.3 42.1 0.76 8.8 29.2 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Utp14 PF04615.8 CDI82580.1 - 5.9 4.9 66.2 6.6 4.7 45.9 1.0 1 0 0 1 1 1 0 Utp14 protein Asp_protease_2 PF13650.1 CDI82585.1 - 0.0011 19.3 0.0 0.0025 18.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 CDI82585.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Dynein_heavy PF03028.10 CDI82586.1 - 1.3e-154 516.0 0.0 4.3e-154 514.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 CDI82586.1 - 1.3e-73 247.2 0.1 3.3e-73 245.9 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_6 PF12774.2 CDI82586.1 - 2.4e-67 226.8 0.0 1.4e-65 221.0 0.0 2.6 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 CDI82586.1 - 2.2e-44 151.0 1.3 1.3e-39 135.4 0.3 2.6 1 1 1 2 2 2 2 ATP-binding dynein motor region D5 AAA_7 PF12775.2 CDI82586.1 - 1.3e-39 135.9 0.0 4.9e-39 134.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 MT PF12777.2 CDI82586.1 - 2.1e-33 115.5 12.3 2.1e-33 115.5 8.5 1.8 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 CDI82586.1 - 1.8e-21 76.3 0.0 2.2e-07 30.6 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.24 CDI82586.1 - 1.2e-07 32.0 0.4 0.39 10.9 0.0 5.4 5 1 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI82586.1 - 4.3e-07 30.0 10.7 4.7 7.1 0.0 7.8 7 1 1 8 8 8 1 AAA ATPase domain AAA_22 PF13401.1 CDI82586.1 - 0.00018 21.6 0.5 13 5.9 0.0 5.4 5 0 0 5 5 5 0 AAA domain AAA_19 PF13245.1 CDI82586.1 - 0.0026 17.4 5.6 11 5.8 0.1 3.9 3 0 0 3 3 3 0 Part of AAA domain AAA_33 PF13671.1 CDI82586.1 - 0.0029 17.4 1.1 1.7 8.5 0.0 4.2 4 0 0 4 4 4 1 AAA domain AAA_17 PF13207.1 CDI82586.1 - 0.009 16.8 0.6 5.1 7.9 0.0 4.2 4 0 0 4 4 2 1 AAA domain T2SE PF00437.15 CDI82586.1 - 0.0099 14.8 1.6 0.038 12.9 0.0 2.7 3 0 0 3 3 3 1 Type II/IV secretion system protein Mg_chelatase PF01078.16 CDI82586.1 - 0.029 13.5 0.1 0.42 9.7 0.0 3.0 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 CDI82586.1 - 0.034 13.6 1.2 0.2 11.1 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.1 CDI82586.1 - 0.041 14.1 1.8 1.7 8.9 0.0 4.4 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.1 CDI82586.1 - 0.94 9.4 7.7 1.8 8.5 0.0 4.4 5 0 0 5 5 4 0 AAA domain AAA_23 PF13476.1 CDI82586.1 - 1.5 9.1 27.9 14 5.9 0.1 4.4 4 0 0 4 4 4 0 AAA domain DHC_N1 PF08385.7 CDI82587.1 - 7.1e-102 341.6 10.1 7.1e-102 341.6 7.0 3.0 2 1 1 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 CDI82587.1 - 7.2e-86 288.2 21.9 1.3e-52 178.7 0.1 6.0 4 1 1 5 5 5 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 CDI82587.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region D1 Proteasome PF00227.21 CDI82589.1 - 7e-49 165.6 0.2 1.2e-48 164.9 0.0 1.5 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.4 CDI82589.1 - 6.7e-11 41.3 0.0 1.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Lipase_GDSL_2 PF13472.1 CDI82591.1 - 0.0059 16.7 0.0 0.0081 16.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family FAM176 PF14851.1 CDI82592.1 - 0.0018 17.9 0.2 0.0022 17.6 0.1 1.1 1 0 0 1 1 1 1 FAM176 family TIMELESS PF04821.9 CDI82592.1 - 0.004 16.4 3.1 0.0046 16.2 1.5 1.5 2 0 0 2 2 2 1 Timeless protein RNase_H2_suC PF08615.6 CDI82592.1 - 0.012 15.5 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Oleosin PF01277.12 CDI82592.1 - 0.015 14.8 0.5 0.025 14.1 0.3 1.3 1 0 0 1 1 1 0 Oleosin DUF4366 PF14283.1 CDI82592.1 - 0.02 14.3 2.9 0.026 13.9 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) AIF-MLS PF14962.1 CDI82592.1 - 0.025 14.2 0.9 0.03 13.9 0.6 1.1 1 0 0 1 1 1 0 Mitochondria Localisation Sequence WES_acyltransf PF03007.11 CDI82592.1 - 0.028 13.9 1.5 0.035 13.6 1.1 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain RIC3 PF15361.1 CDI82592.1 - 0.038 14.2 2.9 0.049 13.8 2.0 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF607 PF04678.8 CDI82592.1 - 0.038 13.9 2.1 0.046 13.6 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Med15 PF09606.5 CDI82592.1 - 0.038 12.2 24.0 0.044 11.9 16.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Gly-zipper_OmpA PF13436.1 CDI82592.1 - 0.038 13.6 14.7 0.055 13.1 10.2 1.2 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Pex14_N PF04695.8 CDI82592.1 - 0.039 14.0 8.4 0.063 13.3 5.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ycf1 PF05758.7 CDI82592.1 - 0.077 10.6 0.4 0.072 10.8 0.3 1.0 1 0 0 1 1 1 0 Ycf1 Apc1 PF12859.2 CDI82592.1 - 0.086 13.0 1.8 1.5 9.0 1.6 2.3 3 0 0 3 3 2 0 Anaphase-promoting complex subunit 1 CRF1 PF10380.4 CDI82592.1 - 0.11 12.7 1.9 0.14 12.4 1.3 1.2 1 0 0 1 1 1 0 Transcription factor CRF1 TMEM51 PF15345.1 CDI82592.1 - 0.13 11.9 4.7 0.17 11.5 3.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Suf PF05843.9 CDI82592.1 - 0.14 11.8 6.4 0.15 11.7 4.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ctr PF04145.10 CDI82592.1 - 0.19 11.7 0.3 0.22 11.5 0.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF2149 PF09919.4 CDI82592.1 - 0.27 11.3 2.8 0.39 10.8 1.9 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) PAT1 PF09770.4 CDI82592.1 - 0.4 8.8 15.4 0.47 8.6 10.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DivIC PF04977.10 CDI82592.1 - 0.43 10.0 10.6 0.79 9.2 7.4 1.4 1 0 0 1 1 1 0 Septum formation initiator OATP PF03137.15 CDI82592.1 - 0.45 8.5 2.0 0.53 8.2 1.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_transf_15 PF01793.11 CDI82592.1 - 0.51 9.2 3.2 0.6 9.0 2.2 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase DUF4616 PF15394.1 CDI82592.1 - 0.52 9.2 4.8 0.67 8.9 3.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4616) FHIPEP PF00771.15 CDI82592.1 - 0.53 8.5 3.2 0.62 8.3 2.2 1.1 1 0 0 1 1 1 0 FHIPEP family Activator_LAG-3 PF11498.3 CDI82592.1 - 0.57 8.8 27.1 0.71 8.5 18.8 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 UPF0560 PF10577.4 CDI82592.1 - 0.59 8.3 10.3 0.68 8.1 7.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FCP1_C PF09309.5 CDI82592.1 - 0.95 8.7 9.5 1.3 8.2 6.6 1.1 1 0 0 1 1 1 0 FCP1, C-terminal DUF2201_N PF13203.1 CDI82592.1 - 0.96 8.5 9.6 1.3 8.1 6.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF4175 PF13779.1 CDI82592.1 - 1.1 6.9 23.7 1.3 6.6 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) APC_CDC26 PF10471.4 CDI82592.1 - 1.2 9.8 18.8 2.3 9.0 13.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 G0-G1_switch_2 PF15103.1 CDI82592.1 - 1.3 9.2 5.2 2.1 8.6 3.6 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 DUF4557 PF15101.1 CDI82592.1 - 1.4 8.7 14.8 2 8.2 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Serinc PF03348.10 CDI82592.1 - 1.8 7.2 6.0 2.2 6.8 4.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Paramyxo_ncap PF00973.14 CDI82592.1 - 1.8 7.1 4.5 2.1 6.9 3.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF775 PF05603.7 CDI82592.1 - 1.9 7.9 7.9 2.3 7.6 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) RAB3GAP2_N PF14655.1 CDI82592.1 - 2 7.3 8.5 2.8 6.8 5.9 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus EIIBC-GUT_N PF03612.9 CDI82592.1 - 2.1 7.9 5.5 2.8 7.5 3.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SHR3_chaperone PF08229.6 CDI82592.1 - 2.6 6.9 8.3 3.4 6.5 5.7 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 FimP PF09766.4 CDI82592.1 - 3 6.7 17.6 4 6.4 12.2 1.1 1 0 0 1 1 1 0 Fms-interacting protein Hid1 PF12722.2 CDI82592.1 - 3.4 5.2 5.7 4.2 4.9 3.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BRF1 PF07741.8 CDI82592.1 - 3.7 7.8 12.9 5.5 7.2 8.9 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RED_N PF07808.8 CDI82592.1 - 4.1 6.5 15.1 5.4 6.1 10.5 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Gag_spuma PF03276.9 CDI82592.1 - 4.1 5.6 15.7 5.1 5.3 10.8 1.1 1 0 0 1 1 1 0 Spumavirus gag protein DUF3138 PF11336.3 CDI82592.1 - 4.2 5.4 14.4 5 5.1 10.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Kei1 PF08552.6 CDI82592.1 - 4.6 6.8 5.8 5.7 6.5 4.0 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PHD_3 PF13922.1 CDI82592.1 - 5.6 7.2 14.4 11 6.2 10.0 1.6 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx DUF2967 PF11179.3 CDI82592.1 - 6.4 6.1 14.1 8.4 5.8 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF3720 PF12517.3 CDI82598.1 - 0.3 11.7 8.9 0.13 13.0 3.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3720) IF-2 PF11987.3 CDI82599.1 - 2.4e-07 30.6 0.0 0.0033 17.2 0.0 2.3 2 0 0 2 2 2 2 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 CDI82599.1 - 0.089 12.9 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 2 DNA_pol3_delta PF06144.8 CDI82602.1 - 0.0049 16.4 0.0 0.0049 16.4 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Lactococcin PF04369.8 CDI82602.1 - 0.17 11.8 3.0 1.4 8.8 2.0 2.4 1 1 0 1 1 1 0 Lactococcin-like family Ribosomal_60s PF00428.14 CDI82602.1 - 1 9.7 10.1 0.92 9.9 5.8 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Adeno_E3_CR2 PF02439.10 CDI82603.1 - 0.096 12.2 0.4 0.15 11.6 0.3 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SET PF00856.23 CDI82605.1 - 1.1e-05 25.8 0.1 3.6e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 SET domain Ribophorin_I PF04597.9 CDI82606.1 - 5.7e-37 127.2 0.0 6e-22 77.7 0.0 2.3 2 0 0 2 2 2 2 Ribophorin I Apolipoprotein PF01442.13 CDI82606.1 - 0.0023 17.4 4.2 0.0043 16.5 2.9 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain TAF4 PF05236.9 CDI82606.1 - 0.036 13.3 2.7 0.055 12.7 1.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family IncA PF04156.9 CDI82608.1 - 0.0059 16.2 12.8 0.0059 16.2 8.9 4.3 2 1 3 5 5 5 1 IncA protein Pox_A_type_inc PF04508.7 CDI82608.1 - 0.75 9.7 0.0 0.75 9.7 0.0 6.8 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.7 CDI82608.1 - 2.1 7.4 9.6 0.87 8.7 0.1 2.8 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Syntaxin-6_N PF09177.6 CDI82608.1 - 3.7 8.0 26.5 0.11 12.9 0.8 5.4 3 1 3 6 6 6 0 Syntaxin 6, N-terminal NPV_P10 PF05531.7 CDI82608.1 - 4.3 7.6 12.5 2 8.7 0.7 5.0 3 3 1 4 4 4 0 Nucleopolyhedrovirus P10 protein AAA_23 PF13476.1 CDI82608.1 - 9.2 6.5 0.0 9.2 6.5 0.0 3.9 1 1 0 2 2 2 0 AAA domain PDZ_2 PF13180.1 CDI82609.1 - 0.013 15.3 0.0 0.14 12.0 0.0 2.3 2 1 1 3 3 3 0 PDZ domain PDZ PF00595.19 CDI82609.1 - 0.093 12.9 0.1 0.42 10.8 0.0 2.1 1 1 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Chromo PF00385.19 CDI82611.1 - 8.8e-13 47.7 0.0 1.3e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Herpes_UL87 PF03043.9 CDI82620.1 - 7 4.9 9.2 8.3 4.6 6.4 1.0 1 0 0 1 1 1 0 Herpesvirus UL87 family Pkinase PF00069.20 CDI82621.1 - 0.00022 20.4 0.0 0.00026 20.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82621.1 - 0.021 13.8 0.0 0.026 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF3446 PF11928.3 CDI82621.1 - 4.3 7.6 17.9 0.46 10.7 2.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) SR-25 PF10500.4 CDI82621.1 - 6.2 6.2 21.3 2.6 7.4 3.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CcmH PF03918.9 CDI82622.1 - 0.07 12.1 1.7 0.1 11.5 0.2 1.9 2 0 0 2 2 2 0 Cytochrome C biogenesis protein TMEM125 PF15109.1 CDI82622.1 - 0.41 10.7 0.0 0.41 10.7 0.0 3.6 2 1 2 4 4 4 0 TMEM125 protein family HhH-GPD PF00730.20 CDI82623.1 - 4.2e-06 26.9 0.1 1.8e-05 24.9 0.0 2.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein APC_CDC26 PF10471.4 CDI82623.1 - 1.4 9.6 19.0 6.5 7.5 2.7 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 DUF2217 PF10265.4 CDI82623.1 - 4.1 6.0 18.0 0.12 11.0 4.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2217) HAD_2 PF13419.1 CDI82624.1 - 0.076 13.2 0.2 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Rad51 PF08423.6 CDI82626.1 - 4.7e-09 35.5 0.9 0.0016 17.4 0.0 4.6 3 1 1 4 4 4 2 Rad51 AAA_25 PF13481.1 CDI82626.1 - 0.0012 18.2 2.3 0.0012 18.2 1.6 3.8 4 1 0 4 4 4 2 AAA domain NACHT PF05729.7 CDI82626.1 - 0.0073 15.9 0.6 0.0073 15.9 0.4 2.6 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 CDI82626.1 - 0.0099 16.0 0.0 1.4 9.0 0.1 3.2 2 1 0 2 2 2 1 AAA domain KaiC PF06745.8 CDI82626.1 - 0.011 14.8 0.0 0.084 11.9 0.0 2.0 2 0 0 2 2 2 0 KaiC Viral_helicase1 PF01443.13 CDI82626.1 - 0.037 13.5 0.0 0.087 12.3 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RecA PF00154.16 CDI82626.1 - 0.082 11.9 0.0 0.33 9.9 0.0 1.9 2 0 0 2 2 2 0 recA bacterial DNA recombination protein AAA_33 PF13671.1 CDI82626.1 - 0.13 12.1 12.2 0.25 11.1 0.2 4.0 4 1 0 4 4 4 0 AAA domain SR-25 PF10500.4 CDI82626.1 - 3.9 6.8 9.6 0.82 9.0 1.5 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.4 CDI82627.1 - 0.0036 16.7 6.8 0.0036 16.7 4.7 5.3 4 1 2 6 6 6 2 Nuclear RNA-splicing-associated protein Suf PF05843.9 CDI82628.1 - 2.5e-21 76.6 0.0 5.9e-14 52.4 0.0 4.2 4 0 0 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.1 CDI82628.1 - 3.7e-06 27.1 8.6 0.084 13.2 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 CDI82628.1 - 4.2e-05 23.3 0.4 1 9.3 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDI82628.1 - 7.1e-05 23.0 19.7 0.045 14.3 0.1 6.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 CDI82628.1 - 0.011 15.5 1.4 3.3 7.8 0.1 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat HAT PF02184.11 CDI82628.1 - 0.037 13.7 0.0 1.3 8.8 0.0 2.6 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Prolactin_RP PF15172.1 CDI82633.1 - 0.0022 17.1 0.2 0.0037 16.4 0.1 1.4 1 0 0 1 1 1 1 Prolactin-releasing peptide SEP PF08059.8 CDI82638.1 - 5.1e-21 74.7 0.1 7.7e-21 74.1 0.0 1.3 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 CDI82638.1 - 1.7e-05 24.8 0.1 2.7e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 UBX domain Fe_hyd_lg_C PF02906.9 CDI82639.1 - 5.4e-41 140.7 4.1 3.4e-12 46.2 0.0 4.9 4 1 0 4 4 4 4 Iron only hydrogenase large subunit, C-terminal domain RNA_pol_Rpc34 PF05158.7 CDI82639.1 - 0.0032 16.7 3.2 0.018 14.2 0.0 2.6 3 0 0 3 3 3 1 RNA polymerase Rpc34 subunit Spt20 PF12090.3 CDI82639.1 - 0.38 10.0 9.2 4.3 6.6 0.3 3.4 3 0 0 3 3 3 0 Spt20 family GTP_EFTU PF00009.22 CDI82640.1 - 9.7e-55 184.9 0.0 2.7e-54 183.4 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 CDI82640.1 - 4.8e-40 135.8 0.1 9.5e-40 134.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 CDI82640.1 - 9.7e-25 86.2 0.0 1.7e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 CDI82640.1 - 1.4e-20 72.9 0.0 2.6e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CDI82640.1 - 4.1e-11 42.8 0.1 1e-10 41.5 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 AIG1 PF04548.11 CDI82640.1 - 0.075 12.1 0.0 4.2 6.4 0.0 2.2 2 0 0 2 2 2 0 AIG1 family DUF4414 PF14377.1 CDI82641.1 - 0.014 15.3 1.0 0.014 15.3 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4414) TFIIA PF03153.8 CDI82641.1 - 0.066 13.0 19.0 0.086 12.7 13.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Draxin PF15550.1 CDI82641.1 - 0.35 10.4 7.8 0.55 9.8 5.4 1.2 1 0 0 1 1 1 0 Draxin DUF959 PF06121.9 CDI82641.1 - 1.7 8.2 16.7 0.41 10.2 4.3 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF959) APC_CDC26 PF10471.4 CDI82641.1 - 4.7 8.0 25.9 0.34 11.6 3.7 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Pkinase PF00069.20 CDI82642.1 - 6.1e-65 218.9 0.0 1.4e-64 217.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82642.1 - 5.1e-37 127.3 0.0 1.1e-36 126.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI82642.1 - 1.1e-05 24.6 0.1 1.1e-05 24.6 0.1 1.9 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.17 CDI82642.1 - 0.00055 19.3 0.8 0.75 9.1 0.2 2.2 2 0 0 2 2 2 2 RIO1 family DUF2252 PF10009.4 CDI82642.1 - 0.0016 17.4 0.1 0.0025 16.7 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) APH PF01636.18 CDI82642.1 - 0.0025 17.5 0.8 0.037 13.7 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 CDI82642.1 - 0.0042 16.4 0.3 0.16 11.2 0.0 2.2 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.9 CDI82642.1 - 0.0062 15.6 0.3 0.038 13.0 0.0 2.2 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family EMP24_GP25L PF01105.19 CDI82643.1 - 2.9e-22 79.2 0.0 5.4e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD NUFIP2 PF15293.1 CDI82644.1 - 0.56 8.8 5.1 0.72 8.5 3.5 1.1 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 Peptidase_M24 PF00557.19 CDI82645.1 - 3.8e-06 26.6 0.2 0.0029 17.2 0.1 2.4 1 1 1 2 2 2 2 Metallopeptidase family M24 Dmrt1 PF12374.3 CDI82645.1 - 5 7.5 7.4 33 4.9 2.1 2.4 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 APC_CDC26 PF10471.4 CDI82649.1 - 0.28 11.9 8.9 0.4 11.4 6.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 PHD_3 PF13922.1 CDI82649.1 - 2.6 8.3 6.2 3.6 7.9 4.3 1.2 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx PPP4R2 PF09184.6 CDI82649.1 - 9 5.7 8.0 9.4 5.6 5.5 1.0 1 0 0 1 1 1 0 PPP4R2 TRAPP PF04051.11 CDI82655.1 - 6.3e-27 93.9 0.0 1.3e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Apt1 PF10351.4 CDI82655.1 - 0.0032 16.4 19.9 0.0099 14.7 0.7 2.3 2 0 0 2 2 2 2 Golgi-body localisation protein domain Ribosomal_60s PF00428.14 CDI82655.1 - 0.045 14.1 0.8 0.045 14.1 0.5 4.0 4 0 0 4 4 4 0 60s Acidic ribosomal protein Hid1 PF12722.2 CDI82656.1 - 1.1 6.8 3.8 1.2 6.7 2.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3357 PF11837.3 CDI82656.1 - 2.1 8.2 6.1 0.24 11.2 0.3 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) RdRP PF05183.7 CDI82657.1 - 1.5e-15 56.9 8.3 1.4e-07 30.5 0.0 3.7 4 0 0 4 4 4 3 RNA dependent RNA polymerase Med15 PF09606.5 CDI82657.1 - 1.2e-06 27.0 29.1 1.2e-06 27.0 20.2 6.2 4 2 1 5 5 5 1 ARC105 or Med15 subunit of Mediator complex non-fungal GTP_EFTU PF00009.22 CDI82659.1 - 1.4e-19 70.2 0.0 1.4e-19 70.2 0.0 2.3 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI82659.1 - 1e-07 31.9 0.0 3.7e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 CDI82659.1 - 1.1e-05 25.9 0.2 1.1e-05 25.9 0.1 2.8 2 1 0 2 2 2 1 Miro-like protein Glyco_hydro_3_C PF01915.17 CDI82659.1 - 9.5e-05 22.0 1.2 9.5e-05 22.0 0.8 3.5 4 1 1 5 5 5 1 Glycosyl hydrolase family 3 C-terminal domain Ras PF00071.17 CDI82659.1 - 0.0012 18.2 0.0 0.0074 15.6 0.0 2.2 2 0 0 2 2 2 1 Ras family FeoB_N PF02421.13 CDI82659.1 - 0.021 14.0 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.18 CDI82659.1 - 0.049 13.4 0.2 0.049 13.4 0.1 4.8 3 2 0 3 3 3 0 Dynamin family Abhydrolase_2 PF02230.11 CDI82660.1 - 8.8e-38 129.9 0.0 9.3e-34 116.7 0.0 2.2 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CDI82660.1 - 2.6e-10 40.2 0.0 4.7e-10 39.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 CDI82660.1 - 6.8e-08 32.2 1.7 1.2e-06 28.0 0.1 2.8 1 1 1 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CDI82660.1 - 0.0048 16.8 0.2 0.025 14.4 0.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CDI82660.1 - 0.0072 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold SR-25 PF10500.4 CDI82660.1 - 0.64 9.4 6.7 1.1 8.6 4.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF418 PF04235.7 CDI82667.1 - 0.015 14.9 0.4 0.56 9.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF418) DUF4128 PF13554.1 CDI82672.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function AAA_2 PF07724.9 CDI82674.1 - 2.3e-34 118.8 0.1 2.4e-33 115.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 CDI82674.1 - 1.2e-08 34.6 0.0 3e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 CDI82674.1 - 1e-06 28.4 0.0 4.1e-06 26.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 CDI82674.1 - 1.1e-06 28.8 0.0 2.6e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CDI82674.1 - 0.00022 20.7 0.0 0.00043 19.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.1 CDI82674.1 - 0.00073 19.8 0.0 0.0046 17.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDI82674.1 - 0.0043 17.8 0.0 0.015 16.1 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CDI82674.1 - 0.0095 15.8 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 CDI82674.1 - 0.012 15.1 0.0 5.9 6.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI82674.1 - 0.015 15.4 0.0 0.28 11.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 CDI82674.1 - 0.019 14.0 0.0 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 CDI82674.1 - 0.029 14.5 0.2 0.43 10.7 0.1 2.4 1 1 0 1 1 1 0 RNA helicase Cache_2 PF08269.6 CDI82676.1 - 1.2 9.1 7.5 2 8.4 5.2 1.3 1 0 0 1 1 1 0 Cache domain TFIIA PF03153.8 CDI82676.1 - 1.7 8.4 22.0 2.7 7.8 15.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI82676.1 - 3.8 5.6 25.7 4.7 5.3 17.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprA-related PF12118.3 CDI82676.1 - 3.9 6.7 31.2 0.072 12.4 9.2 2.2 2 0 0 2 2 2 0 SprA-related family BT1 PF03092.11 CDI82683.1 - 1e-14 54.1 0.2 1.3e-14 53.7 0.2 1.1 1 0 0 1 1 1 1 BT1 family Pol_alpha_B_N PF08418.5 CDI82693.1 - 0.01 15.3 3.1 0.016 14.7 2.2 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal LMF1 PF06762.9 CDI82693.1 - 0.16 10.6 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 Lipase maturation factor Herpes_DNAp_acc PF04929.7 CDI82693.1 - 2.8 6.8 4.8 4.4 6.1 3.4 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor HSP70 PF00012.15 CDI82700.1 - 3.6e-42 144.1 0.0 4.4e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.11 CDI82700.1 - 0.0017 17.9 0.2 0.0028 17.2 0.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Band_7 PF01145.20 CDI82703.1 - 7.1e-14 52.1 3.0 7.1e-14 52.1 2.1 1.4 2 0 0 2 2 2 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 CDI82703.1 - 0.015 14.8 0.1 0.02 14.3 0.1 1.3 1 1 0 1 1 1 0 Enhancer of Polycomb C-terminus Med2 PF11214.3 CDI82703.1 - 0.1 12.6 0.9 0.18 11.8 0.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 Phostensin_N PF13916.1 CDI82704.1 - 8.4 6.4 7.8 8.4 6.4 5.4 1.1 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Med15 PF09606.5 CDI82705.1 - 0.0063 14.7 50.1 0.0074 14.5 34.7 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4175 PF13779.1 CDI82705.1 - 0.0064 14.2 37.9 0.0074 14.0 26.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) DUF605 PF04652.11 CDI82705.1 - 0.031 13.6 35.0 0.04 13.3 24.3 1.0 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 CDI82705.1 - 0.088 12.6 40.7 0.11 12.4 28.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_S15 PF02129.13 CDI82705.1 - 0.11 11.9 14.8 0.14 11.5 10.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) APG6 PF04111.7 CDI82705.1 - 0.11 11.4 23.7 0.14 11.1 16.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 SOBP PF15279.1 CDI82705.1 - 0.13 12.6 23.7 0.16 12.3 16.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SprA-related PF12118.3 CDI82705.1 - 0.16 11.2 56.5 0.21 10.8 39.2 1.1 1 0 0 1 1 1 0 SprA-related family PAT1 PF09770.4 CDI82705.1 - 0.31 9.2 42.5 0.37 8.9 29.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Utp14 PF04615.8 CDI82705.1 - 0.35 8.9 30.8 0.41 8.7 21.3 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4106 PF13388.1 CDI82705.1 - 0.36 9.7 26.0 0.4 9.5 18.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Parvo_coat PF00740.13 CDI82705.1 - 0.59 9.0 22.8 0.65 8.8 15.8 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 LicD PF04991.8 CDI82705.1 - 0.74 9.8 4.1 1 9.4 2.8 1.2 1 0 0 1 1 1 0 LicD family DDRGK PF09756.4 CDI82705.1 - 0.87 8.9 23.4 1.3 8.4 16.2 1.3 1 0 0 1 1 1 0 DDRGK domain DUF940 PF06082.6 CDI82705.1 - 0.99 7.8 14.8 1.3 7.5 10.3 1.1 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) eIF-3_zeta PF05091.7 CDI82705.1 - 1.7 7.2 23.3 1.9 6.9 16.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ycf1 PF05758.7 CDI82705.1 - 1.7 6.2 21.4 2.1 5.9 14.8 1.0 1 0 0 1 1 1 0 Ycf1 FLO_LFY PF01698.11 CDI82705.1 - 1.9 7.2 20.5 2.2 7.0 14.2 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein IncA PF04156.9 CDI82705.1 - 2.3 7.7 22.9 3.8 7.0 15.9 1.4 1 0 0 1 1 1 0 IncA protein SID-1_RNA_chan PF13965.1 CDI82705.1 - 2.5 6.1 8.4 2.6 6.0 5.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PMSI1 PF15322.1 CDI82705.1 - 2.8 6.9 20.3 4.1 6.3 14.1 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Mgr1 PF08602.5 CDI82705.1 - 3.1 6.7 10.8 4 6.3 7.5 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit MRP-S31 PF15433.1 CDI82705.1 - 3.1 7.1 26.6 3.9 6.8 18.4 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 GAGA_bind PF06217.7 CDI82705.1 - 4 7.3 21.6 4.7 7.0 15.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family HemX PF04375.9 CDI82705.1 - 5.2 5.5 32.5 6.9 5.1 22.5 1.1 1 0 0 1 1 1 0 HemX DUF4220 PF13968.1 CDI82705.1 - 8.9 5.3 10.5 9.9 5.1 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Asp-B-Hydro_N PF05279.6 CDI82705.1 - 8.9 6.0 18.6 11 5.8 12.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TCTP PF00838.12 CDI82713.1 - 2.2e-45 154.6 0.9 2.5e-45 154.4 0.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein URO-D PF01208.12 CDI82713.1 - 0.091 11.6 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) tRNA-synt_2b PF00587.20 CDI82716.1 - 5.6e-33 113.9 0.1 7.8e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 CDI82716.1 - 1.1e-19 70.3 1.2 1.1e-19 70.3 0.8 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain RNA_pol_Rpb8 PF03870.10 CDI82718.1 - 4.9e-32 110.9 0.1 5.6e-32 110.8 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 Pkinase PF00069.20 CDI82719.1 - 8.6e-42 143.0 0.0 1.8e-41 141.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI82719.1 - 5.9e-16 58.3 0.0 1e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase P12 PF12669.2 CDI82719.1 - 0.01 15.9 5.1 0.01 15.9 3.5 3.2 3 0 0 3 3 3 0 Virus attachment protein p12 family DUF4557 PF15101.1 CDI82720.1 - 0.26 11.1 16.7 0.018 14.8 6.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Hydrolase PF00702.21 CDI82721.1 - 4.8e-22 79.4 8.8 1.6e-20 74.4 6.1 3.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CDI82721.1 - 4e-21 75.1 0.1 1.2e-20 73.5 0.1 1.9 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 CDI82721.1 - 2.5e-13 50.6 0.0 4e-08 33.6 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDI82721.1 - 1.9e-11 43.7 0.0 3.3e-06 26.9 0.0 2.6 2 0 0 2 2 2 2 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CDI82721.1 - 0.002 17.7 0.4 0.029 13.9 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Syja_N PF02383.13 CDI82725.1 - 3e-48 164.2 0.0 4.2e-47 160.4 0.0 2.0 1 1 0 1 1 1 1 SacI homology domain Apt1 PF10351.4 CDI82725.1 - 5.6 5.7 15.7 3.2 6.5 8.2 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF1645 PF07816.6 CDI82725.1 - 7.8 6.9 35.4 0.74 10.2 7.3 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) MMS1_N PF10433.4 CDI82726.1 - 8.7e-21 73.6 13.6 6.6e-17 60.8 4.9 2.5 2 1 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 CDI82726.1 - 4.7e-19 68.6 0.0 5.3e-11 42.1 0.0 3.3 3 0 0 3 3 3 3 CPSF A subunit region SR-25 PF10500.4 CDI82726.1 - 0.00046 19.7 29.6 0.0015 18.0 6.7 13.6 15 0 0 15 15 15 5 Nuclear RNA-splicing-associated protein DctQ PF04290.7 CDI82728.1 - 0.14 11.9 3.9 1.6 8.4 0.2 2.7 3 0 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF4066 PF13278.1 CDI82728.1 - 0.99 8.6 9.7 0.14 11.4 0.4 2.8 2 1 1 3 3 3 0 Putative amidotransferase Octopine_DH PF02317.12 CDI82731.1 - 4.3e-19 68.6 0.0 5.1e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain DUF1471 PF07338.8 CDI82734.1 - 0.033 13.8 0.8 0.033 13.8 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1471) RsbU_N PF08673.5 CDI82735.1 - 0.1 12.6 0.1 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain HEAT_EZ PF13513.1 CDI82735.1 - 0.12 12.9 0.4 0.16 12.4 0.3 1.3 1 0 0 1 1 1 0 HEAT-like repeat DUF4456 PF14644.1 CDI82735.1 - 0.14 11.3 2.3 0.16 11.1 1.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) NAP PF00956.13 CDI82738.1 - 3.4e-06 26.3 11.0 3.4e-06 26.3 7.6 3.1 2 1 0 2 2 1 1 Nucleosome assembly protein (NAP) SAPS PF04499.10 CDI82738.1 - 0.001 17.8 10.8 0.0012 17.5 7.5 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein BSMAP PF12280.3 CDI82738.1 - 0.0038 17.1 0.5 0.0058 16.5 0.4 1.2 1 0 0 1 1 1 1 Brain specific membrane anchored protein Nop14 PF04147.7 CDI82738.1 - 0.072 11.0 31.0 0.096 10.5 21.5 1.2 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.5 CDI82738.1 - 0.32 10.9 21.7 0.61 10.0 6.8 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Gag_spuma PF03276.9 CDI82738.1 - 0.73 8.0 7.6 0.96 7.7 5.2 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Voldacs PF03517.8 CDI82738.1 - 1 9.1 17.4 2.2 8.1 4.5 2.5 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling CENP-B_dimeris PF09026.5 CDI82738.1 - 1.1 9.5 41.2 1.6 9.0 7.3 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RXT2_N PF08595.6 CDI82738.1 - 1.7 8.4 33.0 0.45 10.3 7.5 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal CobT PF06213.7 CDI82738.1 - 3.5 6.6 35.1 0.54 9.3 10.7 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Nop25 PF09805.4 CDI82738.1 - 3.9 7.5 31.5 0.24 11.4 8.0 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Cwf_Cwc_15 PF04889.7 CDI82738.1 - 4.1 7.0 42.4 0.16 11.6 10.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Prothymosin PF03247.9 CDI82738.1 - 8.9 6.5 51.9 2.2 8.4 11.4 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family Zn-ribbon_8 PF09723.5 CDI82746.1 - 0.88 9.5 4.2 2.8 7.9 2.9 1.8 1 0 0 1 1 1 0 Zinc ribbon domain DUF4089 PF13318.1 CDI82750.1 - 0.053 13.8 1.0 0.053 13.8 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4089) DELLA PF12041.3 CDI82750.1 - 0.057 13.0 0.4 0.13 11.8 0.2 1.7 1 1 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal Inhibitor_I53 PF11714.3 CDI82750.1 - 0.17 11.8 0.8 1.6 8.7 0.0 2.2 2 0 0 2 2 2 0 Thrombin inhibitor Madanin Zip PF02535.17 CDI82751.1 - 1.9 7.4 3.5 2.5 7.0 2.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Tim17 PF02466.14 CDI82752.1 - 3.9e-17 62.4 0.1 7.2e-17 61.6 0.1 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HA2 PF04408.18 CDI82753.1 - 9.9e-10 38.3 0.3 2.9e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDI82753.1 - 1.9e-07 30.8 0.0 6.2e-07 29.2 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold MULE PF10551.4 CDI82754.1 - 0.11 12.6 0.1 6.1 7.0 0.0 2.4 1 1 1 2 2 2 0 MULE transposase domain CRAL_TRIO PF00650.15 CDI82755.1 - 9.1e-18 64.2 0.0 1.4e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Herpes_UL95 PF03038.9 CDI82755.1 - 0.022 13.6 0.3 0.044 12.6 0.2 1.4 1 1 0 1 1 1 0 UL95 family Glyco_transf_10 PF00852.14 CDI82755.1 - 0.11 11.0 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 10 (fucosyltransferase) V_ATPase_I PF01496.14 CDI82756.1 - 0.018 12.9 0.7 0.02 12.7 0.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family cNMP_binding PF00027.24 CDI82757.1 - 0.0054 16.5 0.2 0.38 10.5 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Nol1_Nop2_Fmu PF01189.12 CDI82759.1 - 1.6e-19 70.3 0.0 7e-13 48.5 0.0 4.1 3 1 1 4 4 4 4 NOL1/NOP2/sun family ABC2_membrane PF01061.19 CDI82760.1 - 5.1e-22 78.0 20.1 5.1e-22 78.0 13.9 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 CDI82760.1 - 1.5e-09 38.2 0.0 2.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.2 CDI82760.1 - 0.0023 17.0 23.4 0.0023 17.0 16.2 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_25 PF13481.1 CDI82760.1 - 0.13 11.6 0.1 0.32 10.3 0.1 1.6 2 0 0 2 2 2 0 AAA domain Fijivirus_P9-2 PF06837.6 CDI82760.1 - 5.7 6.0 5.8 11 5.0 4.0 1.4 1 0 0 1 1 1 0 Fijivirus P9-2 protein DEAD PF00270.24 CDI82761.1 - 1.7e-09 37.3 0.0 9e-06 25.2 0.0 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDI82761.1 - 4e-08 32.9 0.0 1.3e-07 31.3 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 CDI82761.1 - 0.0063 16.6 0.0 0.066 13.3 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain Trs65 PF12735.2 CDI82762.1 - 7.3e-12 45.2 0.0 1.6e-07 30.9 0.0 2.1 2 0 0 2 2 2 2 TRAPP trafficking subunit Trs65 Gryzun PF07919.7 CDI82762.1 - 4e-06 25.4 0.1 4.9e-06 25.1 0.0 1.0 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi DUF3122 PF11320.3 CDI82762.1 - 0.064 13.1 0.0 0.09 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) Peptidase_M16 PF00675.15 CDI82763.1 - 6.5e-43 146.0 1.3 1.5e-42 144.8 0.0 2.4 2 1 1 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDI82763.1 - 1.7e-29 102.8 0.0 3.8e-18 65.8 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Curlin_rpt PF07012.7 CDI82763.1 - 0.015 14.9 0.2 6.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Curlin associated repeat RE_XamI PF09572.5 CDI82763.1 - 0.056 12.8 0.0 0.84 9.0 0.0 2.2 2 0 0 2 2 2 0 XamI restriction endonuclease Asp PF00026.18 CDI82764.1 - 3.8e-44 151.2 0.0 1.7e-36 126.1 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDI82764.1 - 9.3e-08 32.1 0.0 6.4e-07 29.4 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 CDI82764.1 - 0.055 13.0 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Amidohydro_2 PF04909.9 CDI82766.1 - 4.7e-08 32.9 0.0 9.3e-08 31.9 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 CDI82766.1 - 0.062 12.9 0.2 0.75 9.3 0.0 2.1 2 0 0 2 2 2 0 Amidohydrolase family DUF1967 PF09269.6 CDI82766.1 - 0.093 12.4 0.0 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) V-SNARE_C PF12352.3 CDI82767.1 - 1.2e-08 34.9 2.3 1.2e-08 34.9 1.6 1.8 1 1 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Gly_acyl_tr_N PF06021.6 CDI82767.1 - 0.92 8.8 4.3 0.7 9.2 0.6 2.2 1 1 0 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase Ribosomal_L28 PF00830.14 CDI82768.1 - 4.5e-08 32.8 0.0 8.4e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L28 family Phasin PF05597.6 CDI82769.1 - 0.78 9.5 10.0 0.3 10.8 0.5 3.2 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Suf PF05843.9 CDI82770.1 - 4.7 6.8 12.4 7.5 6.1 8.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FimP PF09766.4 CDI82770.1 - 7.9 5.4 16.8 11 4.9 11.6 1.1 1 0 0 1 1 1 0 Fms-interacting protein PAT1 PF09770.4 CDI82771.1 - 0.0021 16.3 33.4 0.0026 16.1 23.2 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 RFX5_DNA_bdg PF14621.1 CDI82771.1 - 0.18 11.4 13.0 0.021 14.4 6.2 1.5 2 0 0 2 2 2 0 RFX5 DNA-binding domain RR_TM4-6 PF06459.7 CDI82771.1 - 1.9 8.2 8.6 3.9 7.3 6.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4175 PF13779.1 CDI82771.1 - 4 5.0 34.7 5.7 4.5 24.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RrnaAD PF00398.15 CDI82772.1 - 4.7e-20 71.7 0.0 5.9e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase NDK PF00334.14 CDI82785.1 - 0.081 12.7 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 Nucleoside diphosphate kinase PRMT5 PF05185.11 CDI82788.1 - 1.1e-68 232.2 0.0 3.7e-42 144.7 0.0 6.8 9 1 0 9 9 9 2 PRMT5 arginine-N-methyltransferase DEAD_2 PF06733.10 CDI82788.1 - 6.7e-23 80.9 0.0 3.6e-14 52.5 0.0 3.8 2 1 0 2 2 2 2 DEAD_2 DUF1227 PF06777.6 CDI82788.1 - 2.7e-09 36.8 1.9 2.7e-09 36.8 1.3 5.3 3 1 1 4 4 4 1 Protein of unknown function (DUF1227) Baculo_helicase PF04735.7 CDI82788.1 - 1 6.5 1.4 4.4 4.5 0.9 2.1 2 0 0 2 2 2 0 Baculovirus DNA helicase SNARE PF05739.14 CDI82789.1 - 8.7e-06 25.3 0.6 1.8e-05 24.3 0.4 1.6 1 0 0 1 1 1 1 SNARE domain DUF1183 PF06682.7 CDI82789.1 - 0.0028 17.3 0.1 0.0032 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) Use1 PF09753.4 CDI82789.1 - 0.0072 15.7 0.1 0.0072 15.7 0.0 2.1 2 0 0 2 2 2 1 Membrane fusion protein Use1 RAB3GAP2_N PF14655.1 CDI82789.1 - 0.019 14.0 3.0 0.026 13.5 2.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RskA PF10099.4 CDI82789.1 - 0.056 13.1 7.9 0.093 12.4 0.2 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF912 PF06024.7 CDI82789.1 - 0.2 11.7 1.8 2.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1469 PF07332.6 CDI82789.1 - 2.4 7.9 12.1 2.8 7.7 8.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1469) DUF1212 PF06738.7 CDI82789.1 - 3.1 7.2 7.6 4.4 6.7 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) HemX PF04375.9 CDI82789.1 - 3.5 6.1 13.8 5.4 5.4 8.4 1.8 2 0 0 2 2 2 0 HemX DUF1049 PF06305.6 CDI82790.1 - 0.068 12.6 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) BAF1_ABF1 PF04684.8 CDI82792.1 - 0.97 8.2 2.1 1.6 7.4 1.4 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CTDII PF01556.13 CDI82793.1 - 2e-26 91.6 0.2 3.3e-17 62.1 0.0 2.7 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CDI82793.1 - 2.8e-10 40.0 12.7 5.9e-10 39.0 8.8 1.6 1 0 0 1 1 1 1 DnaJ central domain DZR PF12773.2 CDI82793.1 - 3 7.7 14.2 44 3.9 9.8 2.3 1 1 0 1 1 1 0 Double zinc ribbon E1-E2_ATPase PF00122.15 CDI82805.1 - 1.7e-64 217.0 3.1 2.6e-63 213.1 1.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CDI82805.1 - 1.2e-51 174.8 2.2 2.7e-51 173.6 1.5 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CDI82805.1 - 2.4e-31 109.8 0.0 6.9e-30 105.0 0.0 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDI82805.1 - 5.4e-21 74.3 0.0 1.1e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CDI82805.1 - 1.8e-20 72.1 0.2 6.9e-20 70.2 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 CDI82805.1 - 1.5e-14 54.5 0.0 1.1e-13 51.7 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDI82805.1 - 1.2e-05 25.0 0.5 6.8e-05 22.5 0.4 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 CDI82805.1 - 0.084 12.7 0.0 0.3 11.0 0.0 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Methyltrans_RNA PF04452.9 CDI82807.1 - 3.1e-30 104.9 0.0 1.8e-14 53.3 0.0 2.2 2 0 0 2 2 2 2 RNA methyltransferase DUF2893 PF11459.3 CDI82807.1 - 0.0012 18.5 0.3 0.0031 17.2 0.2 1.6 1 0 0 1 1 1 1 Protein of unknwon function (DUF2893) Ribosomal_60s PF00428.14 CDI82807.1 - 0.017 15.5 21.4 0.033 14.5 5.5 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein Oligomerisation PF02410.10 CDI82808.1 - 2.1e-10 40.5 0.0 4.6e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Oligomerisation domain zf-RING_5 PF14634.1 CDI82809.1 - 0.0001 21.9 7.0 0.0001 21.9 4.9 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDI82809.1 - 0.0039 16.8 7.5 0.0039 16.8 5.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI82809.1 - 0.015 15.2 8.1 0.015 15.2 5.6 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI82809.1 - 6.7 6.6 21.3 75 3.2 14.7 2.3 1 1 1 2 2 2 0 Ring finger domain RAP PF08373.5 CDI82810.1 - 6.5e-17 61.0 0.0 1.2e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 RAP domain IMD PF08397.6 CDI82811.1 - 1.4 8.1 8.7 0.47 9.7 3.6 2.0 2 0 0 2 2 2 0 IRSp53/MIM homology domain APG6 PF04111.7 CDI82811.1 - 1.5 7.8 8.7 0.071 12.1 1.7 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 PAT1 PF09770.4 CDI82811.1 - 2.8 6.0 19.4 3.9 5.5 13.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GNAT_acetyltr_2 PF13718.1 CDI82812.1 - 9.6e-48 162.1 0.1 4.5e-46 156.6 0.1 2.2 1 1 0 1 1 1 1 GNAT acetyltransferase 2 Acetyltransf_7 PF13508.1 CDI82812.1 - 2.3e-05 24.4 0.0 0.00012 22.1 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CDI82812.1 - 2.4e-05 24.2 0.0 6.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SAPS PF04499.10 CDI82812.1 - 0.003 16.2 3.6 0.0038 15.9 2.5 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Nop53 PF07767.6 CDI82812.1 - 0.051 12.5 24.1 0.071 12.0 16.7 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SOBP PF15279.1 CDI82812.1 - 0.084 13.2 2.0 0.11 12.7 1.4 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Borrelia_P83 PF05262.6 CDI82812.1 - 0.094 10.9 12.4 0.12 10.6 8.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein AIF-MLS PF14962.1 CDI82812.1 - 0.11 12.1 19.0 0.16 11.5 13.2 1.2 1 0 0 1 1 1 0 Mitochondria Localisation Sequence DUF2052 PF09747.4 CDI82812.1 - 0.24 11.3 14.0 0.34 10.8 9.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Afi1 PF07792.7 CDI82812.1 - 0.34 10.8 14.5 0.54 10.2 7.5 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nop14 PF04147.7 CDI82812.1 - 0.37 8.6 19.4 0.5 8.2 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.7 CDI82812.1 - 0.4 10.3 19.0 0.61 9.7 13.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Neur_chan_memb PF02932.11 CDI82812.1 - 0.41 10.4 2.6 0.46 10.3 1.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.5 CDI82812.1 - 0.84 9.6 13.6 1.4 8.9 9.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein HAUS6_N PF14661.1 CDI82812.1 - 1.3 8.2 11.1 1.9 7.7 7.7 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4407 PF14362.1 CDI82812.1 - 1.5 7.7 24.3 2 7.2 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.2 CDI82812.1 - 1.5 6.3 10.8 1.9 6.0 7.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spt5_N PF11942.3 CDI82812.1 - 1.7 9.3 19.0 0.68 10.5 7.9 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Pex14_N PF04695.8 CDI82812.1 - 3.9 7.5 14.8 5.7 6.9 2.5 2.3 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Rrn6 PF10214.4 CDI82812.1 - 4.2 5.3 12.6 1.8 6.5 0.5 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Plasmodium_Vir PF05795.6 CDI82812.1 - 4.9 6.2 6.2 6.6 5.8 4.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Allexi_40kDa PF05549.6 CDI82812.1 - 5.1 6.2 10.2 2.6 7.2 5.2 1.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein Spore_coat_CotO PF14153.1 CDI82812.1 - 5.2 6.4 20.1 8.9 5.7 14.0 1.4 1 0 0 1 1 1 0 Spore coat protein CotO PGA2 PF07543.7 CDI82812.1 - 5.4 6.8 17.2 9.3 6.0 11.9 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF1675 PF07897.6 CDI82812.1 - 8 6.2 13.0 12 5.7 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) rve PF00665.21 CDI82826.1 - 2.5e-08 34.0 0.0 5.4e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 CDI82826.1 - 0.046 13.1 0.0 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger Rhodanese PF00581.15 CDI82828.1 - 0.026 14.8 0.0 0.16 12.3 0.0 2.3 2 0 0 2 2 2 0 Rhodanese-like domain Nop25 PF09805.4 CDI82829.1 - 1.3e-11 44.7 14.7 1.3e-11 44.7 10.2 1.7 1 1 0 1 1 1 1 Nucleolar protein 12 (25kDa) ORC6 PF05460.8 CDI82830.1 - 0.39 9.7 5.2 0.45 9.5 3.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PHD PF00628.24 CDI82831.1 - 1.8e-08 33.9 6.3 1.8e-08 33.9 4.4 1.9 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.1 CDI82831.1 - 0.078 12.2 8.6 0.63 9.3 3.8 2.9 3 1 0 3 3 3 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.17 CDI82831.1 - 0.094 12.4 2.6 0.3 10.8 1.8 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_S17 PF00366.15 CDI82832.1 - 7.4e-26 89.9 1.7 1e-25 89.5 1.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S5 PF00333.15 CDI82833.1 - 8.8e-29 99.0 0.4 2.6e-28 97.5 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 CDI82833.1 - 1.5e-21 75.4 0.0 3.1e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain NPV_P10 PF05531.7 CDI82835.1 - 0.0035 17.5 0.3 0.0069 16.6 0.2 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein WD40 PF00400.27 CDI82836.1 - 1.8e-35 119.4 6.7 8.1e-08 31.8 0.0 7.4 6 1 0 6 6 6 6 WD domain, G-beta repeat DUF3312 PF11768.3 CDI82836.1 - 0.054 11.7 0.0 2.1 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) AAA PF00004.24 CDI82839.1 - 2.9e-15 56.6 0.0 5.5e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 CDI82839.1 - 6.7e-13 48.6 0.0 3.6e-12 46.2 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 CDI82839.1 - 1.1e-07 32.1 0.0 5.6e-07 29.7 0.0 2.1 2 1 1 3 3 2 1 AAA domain AAA_14 PF13173.1 CDI82839.1 - 1.4e-05 24.9 0.0 2.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rep_fac_C PF08542.6 CDI82839.1 - 2.4e-05 24.2 0.0 8.7e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain DUF2075 PF09848.4 CDI82839.1 - 6.7e-05 22.0 0.0 9.6e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.5 CDI82839.1 - 0.00011 21.4 0.0 0.0002 20.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_10 PF12846.2 CDI82839.1 - 0.00022 20.7 0.1 0.00091 18.7 0.0 2.1 1 1 0 1 1 1 1 AAA-like domain AAA_19 PF13245.1 CDI82839.1 - 0.00046 19.8 0.1 0.0017 18.0 0.0 2.0 2 0 0 2 2 1 1 Part of AAA domain AAA_30 PF13604.1 CDI82839.1 - 0.00064 19.3 0.0 0.002 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 CDI82839.1 - 0.0012 17.6 0.0 0.3 9.7 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_5 PF07728.9 CDI82839.1 - 0.0012 18.5 0.1 0.011 15.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.1 CDI82839.1 - 0.0018 17.9 0.0 0.005 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 CDI82839.1 - 0.0027 17.2 0.2 0.016 14.6 0.0 2.2 2 1 1 3 3 3 1 FtsK/SpoIIIE family AAA_16 PF13191.1 CDI82839.1 - 0.0031 17.5 0.7 0.029 14.3 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CDI82839.1 - 0.0033 18.2 0.0 0.008 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain DEAD PF00270.24 CDI82839.1 - 0.0034 16.8 0.0 0.44 10.0 0.0 2.4 1 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_18 PF13238.1 CDI82839.1 - 0.0034 17.6 0.0 0.0069 16.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain DUF1118 PF06549.7 CDI82839.1 - 0.0037 17.4 0.9 0.0086 16.2 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1118) Rad17 PF03215.10 CDI82839.1 - 0.007 15.0 0.0 0.25 9.9 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein IstB_IS21 PF01695.12 CDI82839.1 - 0.011 15.1 0.0 0.34 10.3 0.0 2.6 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_33 PF13671.1 CDI82839.1 - 0.012 15.5 0.1 0.018 14.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CDI82839.1 - 0.017 14.5 0.4 0.11 11.9 0.3 2.3 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.7 CDI82839.1 - 0.018 14.0 0.0 0.042 12.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Zot PF05707.7 CDI82839.1 - 0.021 14.3 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) Mg_chelatase PF01078.16 CDI82839.1 - 0.025 13.7 0.0 0.12 11.5 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI BRO1 PF03097.13 CDI82839.1 - 0.032 13.0 0.2 0.045 12.4 0.1 1.2 1 0 0 1 1 1 0 BRO1-like domain AAA_28 PF13521.1 CDI82839.1 - 0.035 14.0 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.9 CDI82839.1 - 0.046 13.6 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_24 PF13479.1 CDI82839.1 - 0.061 12.9 0.0 0.089 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.18 CDI82839.1 - 0.092 11.5 0.0 0.43 9.3 0.0 1.9 1 1 1 2 2 2 0 SNF2 family N-terminal domain GTP_EFTU PF00009.22 CDI82841.1 - 3.6e-62 209.1 0.1 5.4e-62 208.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 CDI82841.1 - 9.1e-36 122.0 0.0 3.4e-35 120.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 CDI82841.1 - 1.5e-18 66.4 0.0 3.1e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 CDI82841.1 - 1.3e-14 53.8 0.0 3.3e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 CDI82841.1 - 3.9e-12 46.1 0.1 9.5e-12 44.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDI82841.1 - 5e-05 23.2 0.1 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CDI82841.1 - 0.071 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Myosin_head PF00063.16 CDI82842.1 - 7.3e-170 566.3 0.3 1.2e-169 565.6 0.2 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 CDI82842.1 - 0.017 15.2 0.0 0.061 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDI82842.1 - 0.024 13.7 0.1 0.046 12.8 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.1 CDI82842.1 - 0.032 13.9 0.0 0.077 12.7 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain UPF0079 PF02367.12 CDI82842.1 - 0.043 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 CDI82842.1 - 0.054 13.8 0.0 0.17 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDI82842.1 - 0.065 13.4 0.0 0.32 11.1 0.0 2.3 1 0 0 1 1 1 0 RNA helicase PRK PF00485.13 CDI82842.1 - 0.07 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family T2SE PF00437.15 CDI82842.1 - 0.078 11.8 0.0 0.21 10.4 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.1 CDI82842.1 - 0.094 12.6 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 CDI82842.1 - 0.11 13.2 0.0 0.28 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ank_2 PF12796.2 CDI82843.1 - 1.4e-27 95.8 0.1 1.5e-14 54.0 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CDI82843.1 - 4.6e-17 61.6 0.3 2.8e-07 30.5 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDI82843.1 - 3.4e-15 56.0 0.0 1.1e-10 41.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 CDI82843.1 - 2.2e-14 52.4 0.1 3.8e-07 29.5 0.1 4.1 3 1 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 CDI82843.1 - 8e-12 44.1 0.0 0.00022 21.1 0.0 4.6 5 0 0 5 5 5 3 Ankyrin repeat DUF4599 PF15371.1 CDI82856.1 - 0.0069 16.4 0.3 0.017 15.1 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4599) Bap31 PF05529.7 CDI82856.1 - 0.011 15.2 1.9 0.017 14.5 1.3 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like HGTP_anticodon PF03129.15 CDI82857.1 - 1.8e-19 69.4 0.2 1e-18 67.0 0.0 2.1 2 1 0 2 2 2 1 Anticodon binding domain DUF1645 PF07816.6 CDI82857.1 - 0.015 15.7 2.0 0.022 15.2 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) SR-25 PF10500.4 CDI82857.1 - 0.94 8.9 8.3 1.4 8.3 5.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 2-oxoacid_dh PF00198.18 CDI82860.1 - 2.2e-12 46.7 0.5 3.2e-12 46.2 0.4 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) NPR3 PF03666.8 CDI82860.1 - 3.4 6.0 14.5 4.3 5.7 10.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PAT1 PF09770.4 CDI82861.1 - 4.6 5.3 14.9 5.6 5.0 10.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Macoilin PF09726.4 CDI82862.1 - 1.1 7.4 58.3 1.4 7.0 40.4 1.1 1 0 0 1 1 1 0 Transmembrane protein SOBP PF15279.1 CDI82862.1 - 2.2 8.5 58.9 3 8.1 40.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein TFIIS_M PF07500.9 CDI82864.1 - 4.5e-10 39.6 1.6 3.2e-09 36.8 0.1 3.1 1 1 1 2 2 2 1 Transcription factor S-II (TFIIS), central domain Chromo PF00385.19 CDI82865.1 - 8.1e-06 25.4 0.3 2e-05 24.1 0.2 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Hid1 PF12722.2 CDI82865.1 - 0.62 7.6 22.2 1.2 6.7 15.4 1.5 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UBA PF00627.26 CDI82866.1 - 6.8e-08 32.1 0.1 2.3e-07 30.4 0.1 2.0 1 0 0 1 1 1 1 UBA/TS-N domain ubiquitin PF00240.18 CDI82866.1 - 2e-06 27.0 0.0 8.4e-06 25.1 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin family SWIB PF02201.13 CDI82867.1 - 9.6e-20 70.0 0.1 1.4e-19 69.5 0.1 1.2 1 0 0 1 1 1 1 SWIB/MDM2 domain DUF1917 PF08939.5 CDI82867.1 - 0.081 12.6 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) Ribosomal_60s PF00428.14 CDI82867.1 - 8 6.9 12.5 19 5.7 8.6 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein RCC1 PF00415.13 CDI82868.1 - 1e-29 102.4 4.9 7e-10 38.9 0.3 5.9 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Myosin_head PF00063.16 CDI82868.1 - 4.5e-27 94.4 0.0 1.5e-11 43.1 0.0 3.1 3 0 0 3 3 3 3 Myosin head (motor domain) RCC1_2 PF13540.1 CDI82868.1 - 2.2e-10 39.8 23.2 7.2e-08 31.8 0.4 5.4 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.22 CDI82868.1 - 0.19 11.4 20.1 0.23 11.1 0.7 5.2 5 0 0 5 5 5 0 IQ calmodulin-binding motif Mannosyl_trans PF05007.8 CDI82869.1 - 4.6e-15 55.9 0.8 7.9e-15 55.1 0.6 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 CDI82869.1 - 4.5e-14 52.1 0.1 6e-14 51.6 0.1 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U ALG3 PF05208.8 CDI82869.1 - 0.00027 20.3 4.0 0.039 13.2 0.9 2.2 2 0 0 2 2 2 2 ALG3 protein DUF2029 PF09594.5 CDI82869.1 - 0.00029 20.4 10.8 0.00036 20.1 6.2 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF2029) BTB PF00651.26 CDI82870.1 - 3e-07 30.4 0.0 6.6e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain FPL PF09758.4 CDI82872.1 - 1.6e-50 170.7 4.2 2.4e-50 170.2 2.9 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein MRG PF05712.8 CDI82872.1 - 0.16 10.8 0.0 0.28 10.0 0.0 1.3 1 0 0 1 1 1 0 MRG HTH_33 PF13592.1 CDI82873.1 - 0.096 12.2 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn helix TatD_DNase PF01026.16 CDI82878.1 - 1e-43 149.4 0.0 1.6e-43 148.7 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase NTF2 PF02136.15 CDI82880.1 - 1.7e-16 60.6 0.0 6.1e-16 58.8 0.0 2.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain AP2 PF00847.15 CDI82881.1 - 2.4e-05 24.4 0.2 2.4e-05 24.4 0.1 1.8 2 0 0 2 2 2 1 AP2 domain C2 PF00168.25 CDI82883.1 - 0.014 15.1 0.0 0.56 10.0 0.0 2.4 2 0 0 2 2 2 0 C2 domain DUF3357 PF11837.3 CDI82884.1 - 0.025 14.4 0.3 0.1 12.4 0.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) H_PPase PF03030.11 CDI82885.1 - 1.5e-100 337.4 20.1 8.1e-61 206.1 4.8 2.1 1 1 0 2 2 2 2 Inorganic H+ pyrophosphatase SprA-related PF12118.3 CDI82887.1 - 0.0011 18.3 41.3 0.0015 17.9 28.6 1.1 1 0 0 1 1 1 1 SprA-related family DUF4175 PF13779.1 CDI82887.1 - 0.0032 15.2 48.0 0.0035 15.1 33.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Zip PF02535.17 CDI82887.1 - 0.0088 15.0 3.2 0.014 14.4 2.2 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter DUF788 PF05620.6 CDI82887.1 - 0.022 14.6 8.8 0.022 14.6 6.1 2.3 1 1 1 2 2 1 0 Protein of unknown function (DUF788) AAA_23 PF13476.1 CDI82887.1 - 0.11 12.8 21.1 0.14 12.4 14.6 1.3 1 0 0 1 1 1 0 AAA domain Dicty_REP PF05086.7 CDI82887.1 - 0.12 10.0 12.4 0.14 9.8 8.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AMP-binding PF00501.23 CDI82887.1 - 0.27 9.5 2.0 0.32 9.3 1.4 1.1 1 0 0 1 1 1 0 AMP-binding enzyme Bac_luciferase PF00296.15 CDI82887.1 - 0.34 9.9 4.3 0.97 8.4 3.0 1.8 1 1 0 1 1 1 0 Luciferase-like monooxygenase Med15 PF09606.5 CDI82887.1 - 0.34 9.0 62.2 0.42 8.7 43.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal NCU-G1 PF15065.1 CDI82887.1 - 0.46 9.1 7.2 0.56 8.8 5.0 1.1 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 FHIPEP PF00771.15 CDI82887.1 - 0.61 8.3 10.2 0.74 8.0 7.1 1.2 1 0 0 1 1 1 0 FHIPEP family GAGA_bind PF06217.7 CDI82887.1 - 0.82 9.5 19.5 1.1 9.2 13.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4011 PF13195.1 CDI82887.1 - 1.1 9.2 12.6 1.7 8.6 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) DDHD PF02862.12 CDI82887.1 - 1.4 8.7 17.0 1.8 8.3 11.8 1.2 1 0 0 1 1 1 0 DDHD domain N6_N4_Mtase PF01555.13 CDI82887.1 - 1.6 8.1 6.2 2.2 7.7 4.3 1.2 1 0 0 1 1 1 0 DNA methylase Presenilin PF01080.12 CDI82887.1 - 1.7 7.3 10.0 2.2 7.0 6.9 1.1 1 0 0 1 1 1 0 Presenilin APG6 PF04111.7 CDI82887.1 - 1.9 7.4 28.4 2.1 7.3 19.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CDC45 PF02724.9 CDI82887.1 - 2.4 6.0 19.5 2.9 5.8 13.5 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.8 CDI82887.1 - 3.3 7.5 35.1 4.4 7.0 24.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tau95 PF09734.4 CDI82887.1 - 4.2 6.5 11.7 4.8 6.4 8.1 1.1 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit FAM60A PF15396.1 CDI82887.1 - 5.4 6.7 14.9 7.1 6.3 10.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Mem_trans PF03547.13 CDI82887.1 - 5.9 5.0 11.3 8.1 4.6 7.8 1.1 1 0 0 1 1 1 0 Membrane transport protein PAT1 PF09770.4 CDI82887.1 - 6 4.9 52.0 8 4.5 36.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.7 CDI82887.1 - 8 4.9 26.0 9.9 4.6 18.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Gti1_Pac2 PF09729.4 CDI82887.1 - 8 6.2 10.9 12 5.6 7.5 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.17 CDI82890.1 - 1.8e-15 56.7 13.2 5.2e-10 38.8 6.4 4.1 1 1 2 3 3 3 2 ZIP Zinc transporter HemX PF04375.9 CDI82890.1 - 0.0024 16.5 6.6 0.0024 16.5 4.6 4.2 2 1 2 4 4 4 2 HemX DUF1360 PF07098.6 CDI82890.1 - 0.018 14.7 0.3 0.018 14.7 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) FimP PF09766.4 CDI82890.1 - 0.38 9.7 0.0 0.38 9.7 0.0 2.3 2 0 0 2 2 2 0 Fms-interacting protein GP120 PF00516.13 CDI82890.1 - 2.3 6.3 5.4 0.61 8.2 1.3 1.6 1 1 0 1 1 1 0 Envelope glycoprotein GP120 Actin PF00022.14 CDI82891.1 - 2e-20 72.5 0.0 2.6e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Actin Herpes_UL87 PF03043.9 CDI82892.1 - 0.041 12.2 2.7 0.051 11.9 1.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL87 family FLO_LFY PF01698.11 CDI82892.1 - 0.093 11.5 26.9 0.14 10.9 18.6 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein Cwf_Cwc_15 PF04889.7 CDI82892.1 - 0.2 11.3 39.9 0.32 10.6 27.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Baculo_PP31 PF05311.6 CDI82892.1 - 0.33 10.1 17.8 0.5 9.5 12.3 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) RNA_pol_3_Rpc31 PF11705.3 CDI82892.1 - 1 9.2 27.6 2 8.3 19.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Ndc1_Nup PF09531.5 CDI82892.1 - 1.3 7.3 7.5 1.7 6.9 5.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PPP4R2 PF09184.6 CDI82892.1 - 1.5 8.2 25.3 2.3 7.6 17.5 1.3 1 0 0 1 1 1 0 PPP4R2 Zip PF02535.17 CDI82892.1 - 3.6 6.4 4.8 5.5 5.9 3.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.8 CDI82892.1 - 4.1 6.8 15.5 7.3 6.0 10.8 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CENP-B_dimeris PF09026.5 CDI82892.1 - 5.7 7.2 15.9 18 5.6 11.1 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ribosomal_L18e PF00828.14 CDI82893.1 - 6.1e-33 113.9 0.0 7.3e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Myco_19_kDa PF05481.7 CDI82894.1 - 0.49 10.2 4.4 0.65 9.7 3.1 1.1 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen DUF687 PF05095.7 CDI82897.1 - 0.022 13.1 1.6 0.024 13.0 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF687) Tmemb_185A PF10269.4 CDI82897.1 - 0.083 12.4 0.3 0.09 12.3 0.2 1.0 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein Mem_trans PF03547.13 CDI82897.1 - 0.24 9.6 1.8 0.26 9.5 1.2 1.0 1 0 0 1 1 1 0 Membrane transport protein Cyclin_C PF02984.14 CDI82897.1 - 0.33 10.8 3.0 0.35 10.7 2.1 1.1 1 0 0 1 1 1 0 Cyclin, C-terminal domain Per1 PF04080.8 CDI82897.1 - 1.1 8.6 3.8 1.1 8.5 2.6 1.1 1 0 0 1 1 1 0 Per1-like Med3 PF11593.3 CDI82897.1 - 5.3 6.1 10.6 4.9 6.2 7.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Myosin_head PF00063.16 CDI82900.1 - 9e-24 83.5 2.7 2e-14 52.6 0.2 2.1 1 1 1 2 2 2 2 Myosin head (motor domain) Glycolytic PF00274.14 CDI82903.1 - 1.2e-44 152.2 0.0 1.3e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I BT1 PF03092.11 CDI82905.1 - 1.1e-16 60.6 0.3 1.3e-16 60.4 0.2 1.1 1 0 0 1 1 1 1 BT1 family DUF3458 PF11940.3 CDI82907.1 - 7.4e-19 67.8 0.1 7.9e-19 67.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Pyr_redox_2 PF07992.9 CDI82910.1 - 2.5e-38 131.9 4.0 9.6e-27 94.1 3.5 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDI82910.1 - 2.3e-22 79.1 6.7 1.9e-19 69.8 0.2 3.2 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 CDI82910.1 - 7.5e-19 67.7 0.0 1.8e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain FAD_oxidored PF12831.2 CDI82910.1 - 2.3e-11 43.4 4.6 4.1e-10 39.3 1.5 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.17 CDI82910.1 - 3.4e-10 39.3 3.1 1.3e-09 37.4 0.3 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 CDI82910.1 - 3.1e-09 37.1 0.2 1e-05 25.6 0.1 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CDI82910.1 - 7.6e-07 28.3 3.8 7.6e-07 28.3 2.6 2.3 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 CDI82910.1 - 4.8e-06 25.2 7.4 0.00027 19.5 0.1 3.8 3 1 1 4 4 4 2 HI0933-like protein K_oxygenase PF13434.1 CDI82910.1 - 8.6e-06 24.8 0.7 0.044 12.6 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CDI82910.1 - 1.4e-05 25.0 6.0 0.0012 18.7 1.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CDI82910.1 - 1.6e-05 23.9 7.2 0.0062 15.4 0.1 3.5 4 0 0 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.12 CDI82910.1 - 5.8e-05 22.2 2.3 8.8e-05 21.7 0.3 2.1 2 1 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 CDI82910.1 - 0.00014 21.0 8.7 0.17 10.8 0.5 3.1 2 1 0 3 3 3 3 FAD binding domain AlaDh_PNT_C PF01262.16 CDI82910.1 - 0.0053 16.3 1.0 0.31 10.6 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 CDI82910.1 - 0.0065 16.1 2.3 0.0079 15.8 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 CDI82910.1 - 0.011 14.9 0.1 10 5.2 0.0 3.1 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 CDI82910.1 - 0.12 12.6 0.2 3.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.7 CDI82910.1 - 1.1 8.1 5.4 0.89 8.3 0.5 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein Peptidase_S9_N PF02897.10 CDI82911.1 - 8.2e-106 354.0 0.1 1.2e-105 353.4 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.16 CDI82911.1 - 4e-58 196.1 0.0 6.7e-58 195.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CDI82911.1 - 8.1e-05 22.4 0.1 0.00017 21.3 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDI82911.1 - 0.016 14.7 0.3 0.062 12.8 0.2 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 CDI82911.1 - 0.064 12.8 0.3 0.21 11.1 0.2 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF4227 PF14004.1 CDI82911.1 - 0.079 12.8 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) BAAT_C PF08840.6 CDI82911.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Nop25 PF09805.4 CDI82913.1 - 0.0088 16.1 2.0 0.0088 16.1 1.4 1.4 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) TPR_MLP1_2 PF07926.7 CDI82915.1 - 8e-07 28.8 9.7 8e-07 28.8 6.7 6.4 4 1 2 6 6 6 1 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.7 CDI82915.1 - 0.088 11.9 27.0 0.029 13.5 2.4 4.7 3 1 2 5 5 5 0 Reovirus sigma C capsid protein TBPIP PF07106.8 CDI82915.1 - 1.1 8.7 69.9 0.065 12.7 0.3 6.6 3 2 2 6 6 6 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Myosin_head PF00063.16 CDI82921.1 - 9.6e-94 314.7 0.1 1.4e-93 314.2 0.1 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Zeta_toxin PF06414.7 CDI82921.1 - 0.0034 16.5 0.1 0.0092 15.0 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 CDI82921.1 - 0.0085 16.2 0.5 0.054 13.6 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDI82921.1 - 0.027 15.3 0.4 0.11 13.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 CDI82921.1 - 0.028 13.5 0.0 0.54 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Viral_helicase1 PF01443.13 CDI82921.1 - 0.2 11.1 2.7 2.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase tRNA-synt_2b PF00587.20 CDI82926.1 - 1.2e-39 135.6 1.2 1.5e-39 135.3 0.8 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Spore_coat_CotO PF14153.1 CDI82926.1 - 0.004 16.6 8.1 0.004 16.6 5.6 2.1 2 0 0 2 2 2 1 Spore coat protein CotO Suf PF05843.9 CDI82926.1 - 0.0062 16.2 11.4 0.011 15.5 7.9 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) SR-25 PF10500.4 CDI82926.1 - 0.0069 15.8 13.2 0.0069 15.8 9.2 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF572 PF04502.8 CDI82926.1 - 0.0091 15.2 14.0 0.013 14.7 9.7 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) Pex14_N PF04695.8 CDI82926.1 - 0.03 14.3 12.1 0.082 12.9 8.4 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hid1 PF12722.2 CDI82926.1 - 0.11 10.1 8.1 0.15 9.6 5.6 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Baculo_PP31 PF05311.6 CDI82926.1 - 0.13 11.4 10.1 0.25 10.5 7.0 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Ndc1_Nup PF09531.5 CDI82926.1 - 0.16 10.3 3.2 0.16 10.3 2.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.14 CDI82926.1 - 0.22 11.2 21.0 0.37 10.5 14.6 1.4 1 1 0 1 1 1 0 SPX domain Zip PF02535.17 CDI82926.1 - 0.3 10.0 1.1 0.38 9.7 0.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Activator_LAG-3 PF11498.3 CDI82926.1 - 0.84 8.3 25.2 1.3 7.6 17.5 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 AvrE PF11725.3 CDI82926.1 - 1.1 6.2 13.6 1.4 5.8 9.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor Presenilin PF01080.12 CDI82926.1 - 1.3 7.7 5.3 1.8 7.3 3.7 1.3 1 0 0 1 1 1 0 Presenilin Kei1 PF08552.6 CDI82926.1 - 1.3 8.6 3.5 2.6 7.6 2.5 1.5 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Herpes_DNAp_acc PF04929.7 CDI82926.1 - 2.7 6.8 10.6 4.5 6.1 7.3 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor ACCA PF03255.9 CDI82926.1 - 3.9 7.0 9.2 5.3 6.5 0.9 2.3 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Raftlin PF15250.1 CDI82926.1 - 3.9 5.9 15.1 7.2 5.0 10.5 1.4 1 1 0 1 1 1 0 Raftlin Gag_spuma PF03276.9 CDI82926.1 - 7.2 4.8 26.1 10 4.2 18.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Metal_resist PF13801.1 CDI82930.1 - 0.11 12.4 0.4 0.11 12.4 0.3 2.3 2 0 0 2 2 2 0 Heavy-metal resistance YajC PF02699.10 CDI82931.1 - 0.79 9.4 0.0 0.79 9.4 0.0 4.5 4 0 0 4 4 4 0 Preprotein translocase subunit Cwf_Cwc_15 PF04889.7 CDI82932.1 - 0.0081 15.8 18.2 0.26 10.9 1.9 2.2 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein LMBR1 PF04791.11 CDI82932.1 - 0.51 8.8 4.0 0.77 8.2 2.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM60A PF15396.1 CDI82932.1 - 0.59 9.8 20.5 0.74 9.5 0.7 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Utp14 PF04615.8 CDI82932.1 - 0.67 8.0 25.6 1 7.4 17.8 1.2 1 0 0 1 1 1 0 Utp14 protein DUF2052 PF09747.4 CDI82932.1 - 4.2 7.2 23.3 4.3 7.2 10.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF1510 PF07423.6 CDI82932.1 - 9.7 5.4 27.1 4.8 6.4 13.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) DUF1162 PF06650.7 CDI82933.1 - 2e-11 43.6 0.0 2.4e-08 33.5 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1162) rve PF00665.21 CDI82936.1 - 2.1e-19 69.8 0.0 4.8e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.19 CDI82936.1 - 2.8e-14 52.5 0.2 5.4e-14 51.6 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-CCHC_2 PF13696.1 CDI82936.1 - 0.52 9.8 3.1 0.31 10.5 0.6 1.8 2 0 0 2 2 2 0 Zinc knuckle PDEase_I PF00233.14 CDI82937.1 - 9.2e-17 61.5 0.0 1.1e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Pkinase PF00069.20 CDI82938.1 - 3.5e-41 141.0 0.0 6.3e-23 81.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain EF-hand_1 PF00036.27 CDI82938.1 - 3.6e-25 85.3 0.0 2.3e-06 26.5 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDI82938.1 - 1.9e-23 82.3 0.1 3.4e-11 43.0 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDI82938.1 - 1.2e-19 68.3 0.0 6.2e-05 22.5 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 CDI82938.1 - 3.8e-18 64.8 2.1 3.1e-06 26.7 0.1 4.6 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 CDI82938.1 - 1.5e-17 62.0 0.1 2.6e-06 26.5 0.0 4.0 4 0 0 4 4 4 3 EF hand Pkinase_Tyr PF07714.12 CDI82938.1 - 4.8e-17 61.8 0.0 1.1e-12 47.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase CBM_20 PF00686.14 CDI82938.1 - 1.3e-13 50.3 0.0 2.5e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain SPARC_Ca_bdg PF10591.4 CDI82938.1 - 4.9e-07 29.7 0.0 0.00035 20.5 0.0 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 CDI82938.1 - 2.8e-06 27.0 0.0 0.0032 17.1 0.0 2.5 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1194 PF06707.6 CDI82938.1 - 0.15 10.9 0.0 0.3 10.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) SprA-related PF12118.3 CDI82939.1 - 0.0022 17.4 5.9 0.0022 17.4 4.1 5.5 4 1 1 5 5 5 2 SprA-related family Spt20 PF12090.3 CDI82939.1 - 1 8.6 24.5 3.8 6.8 0.1 3.7 3 0 0 3 3 3 0 Spt20 family AAA_33 PF13671.1 CDI82941.1 - 2.3e-06 27.5 0.9 0.0014 18.5 0.2 2.6 2 1 0 2 2 2 2 AAA domain KTI12 PF08433.5 CDI82941.1 - 1.5e-05 24.3 0.4 0.016 14.4 0.0 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_22 PF13401.1 CDI82941.1 - 7e-05 22.9 0.0 0.01 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CDI82941.1 - 0.00069 18.8 0.1 0.0019 17.4 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 CDI82941.1 - 0.0015 18.5 1.0 0.0015 18.5 0.7 3.5 2 2 1 3 3 3 1 AAA ATPase domain G-alpha PF00503.15 CDI82941.1 - 0.0064 15.2 2.3 0.0064 15.2 1.6 1.7 2 0 0 2 2 1 1 G-protein alpha subunit Mem_trans PF03547.13 CDI82941.1 - 0.0069 14.7 1.4 0.052 11.8 0.1 2.1 2 0 0 2 2 2 1 Membrane transport protein AAA_17 PF13207.1 CDI82941.1 - 0.007 17.1 0.0 0.014 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CDI82941.1 - 0.034 14.3 0.1 0.14 12.3 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 CDI82941.1 - 0.051 13.8 0.0 0.089 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CDI82941.1 - 0.068 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Macoilin PF09726.4 CDI82941.1 - 0.1 10.9 29.1 0.081 11.1 9.2 2.5 2 0 0 2 2 2 0 Transmembrane protein CDC45 PF02724.9 CDI82941.1 - 3.5 5.5 8.9 0.36 8.8 0.6 2.1 2 0 0 2 2 2 0 CDC45-like protein SPT6_acidic PF14632.1 CDI82942.1 - 4.5e-10 39.5 8.8 4.5e-10 39.5 6.1 7.5 5 2 0 5 5 5 1 Acidic N-terminal SPT6 HTH_44 PF14641.1 CDI82942.1 - 1.3e-06 28.4 0.0 3.5e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.1 CDI82942.1 - 0.0044 17.1 0.0 0.015 15.3 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif DegS PF05384.6 CDI82943.1 - 0.00055 19.1 0.5 0.00099 18.3 0.3 1.3 1 0 0 1 1 1 1 Sensor protein DegS WbqC PF08889.6 CDI82943.1 - 0.11 11.8 1.5 0.13 11.6 1.1 1.1 1 0 0 1 1 1 0 WbqC-like protein family Kelch_4 PF13418.1 CDI82945.1 - 0.012 15.3 0.1 0.051 13.3 0.0 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.1 CDI82945.1 - 0.023 14.8 0.0 0.13 12.4 0.0 2.2 2 0 0 2 2 2 0 Kelch motif PAM2 PF07145.10 CDI82945.1 - 0.039 13.4 0.6 0.084 12.4 0.4 1.5 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Kelch_1 PF01344.20 CDI82945.1 - 0.3 10.6 0.0 0.62 9.6 0.0 1.5 1 0 0 1 1 1 0 Kelch motif RNA_pol_Rpb1_5 PF04998.12 CDI82946.1 - 5.2e-100 334.2 0.2 8e-100 333.6 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 CDI82946.1 - 1.3e-97 327.0 0.0 2.4e-97 326.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 CDI82946.1 - 2e-68 229.5 0.0 4.2e-68 228.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 CDI82946.1 - 3.2e-44 150.4 0.0 1.1e-43 148.7 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 CDI82946.1 - 8.8e-44 148.4 0.7 2.2e-43 147.1 0.5 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_6 PF04992.9 CDI82946.1 - 5e-42 143.7 2.4 9.4e-42 142.8 1.6 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_4 PF05000.12 CDI82946.1 - 1.9e-39 133.7 0.2 4.5e-39 132.5 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 LSM PF01423.17 CDI82947.1 - 1.5e-14 53.2 0.3 1.8e-14 53.0 0.2 1.1 1 0 0 1 1 1 1 LSM domain RCC1 PF00415.13 CDI82948.1 - 1.1e-10 41.5 0.1 6.7e-06 26.2 0.0 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI82948.1 - 4.1e-07 29.4 6.3 8.8e-05 22.0 0.2 3.3 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Cytochrom_C PF00034.16 CDI82950.1 - 3.5e-10 40.5 0.1 5.6e-10 39.9 0.1 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 CDI82950.1 - 7.3e-07 29.2 2.7 2.2e-06 27.7 1.9 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 CDI82950.1 - 0.0037 16.7 0.0 0.0096 15.3 0.0 1.6 2 0 0 2 2 2 1 Cytochrome c-550 domain Haem_bd PF14376.1 CDI82950.1 - 0.085 12.5 0.0 0.18 11.5 0.0 1.5 2 0 0 2 2 2 0 Haem-binding domain GIDA PF01134.17 CDI82951.1 - 4.6e-99 331.9 18.2 8.9e-54 182.8 0.0 4.6 3 1 1 4 4 4 3 Glucose inhibited division protein A Pyr_redox PF00070.22 CDI82951.1 - 0.022 15.1 1.2 0.091 13.1 0.8 2.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Acetyltransf_1 PF00583.19 CDI82952.1 - 2.6e-06 27.3 0.1 8.7e-06 25.6 0.1 2.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CDI82952.1 - 0.0014 18.7 0.0 0.0033 17.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF947 PF06102.7 CDI82952.1 - 1.9 8.2 8.8 0.25 11.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF947) WD40 PF00400.27 CDI82953.1 - 6.4e-09 35.3 6.0 0.00028 20.6 0.0 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat MRP-S31 PF15433.1 CDI82953.1 - 0.015 14.7 3.5 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Spore_YhcN_YlaJ PF09580.5 CDI82955.1 - 0.003 17.6 5.7 0.0043 17.1 4.0 1.2 1 0 0 1 1 1 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) XRCC4 PF06632.7 CDI82955.1 - 0.0049 15.7 5.7 0.0062 15.4 4.0 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Macoilin PF09726.4 CDI82955.1 - 0.0082 14.4 9.1 0.0092 14.3 6.3 1.2 1 0 0 1 1 1 1 Transmembrane protein Plasmodium_Vir PF05795.6 CDI82955.1 - 0.0086 15.3 4.6 0.011 14.9 3.2 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Mem_trans PF03547.13 CDI82955.1 - 0.0093 14.2 2.3 0.0096 14.2 1.6 1.1 1 0 0 1 1 1 1 Membrane transport protein DUF2217 PF10265.4 CDI82955.1 - 0.012 14.3 8.1 0.014 14.2 5.6 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Gti1_Pac2 PF09729.4 CDI82955.1 - 0.017 15.0 8.8 0.017 15.0 6.1 1.5 2 0 0 2 2 2 0 Gti1/Pac2 family FAM176 PF14851.1 CDI82955.1 - 0.024 14.3 3.5 0.042 13.5 2.4 1.4 1 0 0 1 1 1 0 FAM176 family Prog_receptor PF02161.10 CDI82955.1 - 0.029 13.2 3.3 0.032 13.0 2.3 1.1 1 0 0 1 1 1 0 Progesterone receptor Pox_Ag35 PF03286.9 CDI82955.1 - 0.038 13.5 6.6 0.06 12.8 4.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TraV PF09676.5 CDI82955.1 - 0.055 14.1 6.1 0.75 10.5 1.8 2.2 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) BAF1_ABF1 PF04684.8 CDI82955.1 - 0.1 11.4 8.9 0.15 10.9 6.2 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.12 CDI82955.1 - 0.13 11.0 4.6 0.13 11.0 3.2 1.2 1 0 0 1 1 1 0 Presenilin Kei1 PF08552.6 CDI82955.1 - 0.14 11.8 2.3 0.25 11.0 1.6 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 BTV_NS2 PF04514.7 CDI82955.1 - 0.14 11.0 2.7 0.23 10.2 1.9 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 SLD3 PF08639.5 CDI82955.1 - 0.15 10.6 12.6 0.18 10.4 8.7 1.2 1 0 0 1 1 1 0 DNA replication regulator SLD3 Dsh_C PF12316.3 CDI82955.1 - 0.16 12.0 10.8 0.22 11.5 7.5 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal GATA-N PF05349.7 CDI82955.1 - 0.19 11.8 5.7 0.28 11.3 4.0 1.2 1 0 0 1 1 1 0 GATA-type transcription activator, N-terminal Sporozoite_P67 PF05642.6 CDI82955.1 - 0.23 9.2 10.5 0.28 8.9 7.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen WBP-1 PF11669.3 CDI82955.1 - 0.25 11.4 2.9 0.14 12.2 0.5 1.7 2 0 0 2 2 1 0 WW domain-binding protein 1 Otopetrin PF03189.8 CDI82955.1 - 0.25 10.2 1.7 0.31 9.9 1.2 1.1 1 0 0 1 1 1 0 Otopetrin DUF1510 PF07423.6 CDI82955.1 - 0.28 10.5 11.2 0.46 9.8 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RAP1 PF07218.6 CDI82955.1 - 0.3 9.1 8.7 0.32 9.0 6.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ndc1_Nup PF09531.5 CDI82955.1 - 0.42 8.9 7.9 0.41 9.0 5.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.17 CDI82955.1 - 0.47 9.4 2.7 0.66 8.9 1.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1675 PF07897.6 CDI82955.1 - 0.49 10.2 11.7 0.85 9.4 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Enkurin PF13864.1 CDI82955.1 - 0.94 9.7 8.4 1.1 9.4 3.6 2.0 2 0 0 2 2 2 0 Calmodulin-binding MRI PF15325.1 CDI82955.1 - 1.2 10.1 7.9 2.2 9.2 5.5 1.4 1 0 0 1 1 1 0 Modulator of retrovirus infection NPR3 PF03666.8 CDI82955.1 - 2.2 6.7 13.6 3.1 6.2 9.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.11 CDI82955.1 - 2.4 7.9 11.4 3.2 7.5 7.9 1.2 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.3 CDI82955.1 - 2.6 7.6 9.9 0.9 9.2 4.8 1.7 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF4512 PF14975.1 CDI82955.1 - 2.7 8.8 8.6 2.1 9.2 4.8 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4512) DivIC PF04977.10 CDI82955.1 - 2.8 7.4 9.6 1.7 8.1 3.1 2.2 2 0 0 2 2 2 0 Septum formation initiator Ctr PF04145.10 CDI82955.1 - 4 7.4 9.4 5.8 6.9 6.5 1.5 1 1 0 1 1 1 0 Ctr copper transporter family RILP PF11461.3 CDI82963.1 - 0.00022 21.2 2.6 0.04 14.0 0.0 3.2 3 0 0 3 3 2 1 Rab interacting lysosomal protein HALZ PF02183.13 CDI82963.1 - 0.00042 19.9 24.8 0.028 14.1 0.8 5.8 6 0 0 6 6 6 2 Homeobox associated leucine zipper Uds1 PF15456.1 CDI82963.1 - 0.00079 19.4 5.8 1.6 8.7 1.6 3.5 3 0 0 3 3 3 2 Up-regulated During Septation CCDC-167 PF15188.1 CDI82963.1 - 0.0012 18.7 17.0 0.47 10.4 0.0 3.9 4 0 0 4 4 4 3 Coiled-coil domain-containing protein 167 Lzipper-MIP1 PF14389.1 CDI82963.1 - 0.0013 18.8 17.9 0.068 13.2 1.5 4.5 5 0 0 5 5 4 2 Leucine-zipper of ternary complex factor MIP1 DUF2353 PF09789.4 CDI82963.1 - 0.0022 17.3 3.0 0.0022 17.3 2.1 2.6 2 1 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) HAP1_N PF04849.8 CDI82963.1 - 0.0086 15.0 11.8 0.01 14.7 0.8 2.4 2 1 0 2 2 2 1 HAP1 N-terminal conserved region FlxA PF14282.1 CDI82963.1 - 0.0096 15.8 5.9 2.8 7.9 0.4 4.3 4 0 0 4 4 4 1 FlxA-like protein DUF972 PF06156.8 CDI82963.1 - 0.015 15.5 12.0 1.4 9.2 0.5 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF972) Tnp_P_element PF12017.3 CDI82963.1 - 0.054 12.7 7.1 8.7 5.4 0.1 3.9 4 0 0 4 4 4 0 Transposase protein Rho_Binding PF08912.6 CDI82963.1 - 0.081 13.2 0.1 0.081 13.2 0.0 4.0 4 0 0 4 4 4 0 Rho Binding LURAP PF14854.1 CDI82963.1 - 0.084 12.5 4.6 9.7 5.9 0.4 3.5 3 0 0 3 3 3 0 Leucine rich adaptor protein Atg14 PF10186.4 CDI82963.1 - 0.26 10.2 5.8 0.92 8.3 0.6 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TSC22 PF01166.13 CDI82963.1 - 0.28 11.1 16.7 19 5.3 0.0 5.0 4 1 1 5 5 5 0 TSC-22/dip/bun family IncA PF04156.9 CDI82963.1 - 0.46 10.0 17.4 2.5e+02 1.1 12.1 3.4 1 1 0 1 1 1 0 IncA protein IFP_35_N PF07334.8 CDI82963.1 - 0.58 10.1 7.0 7.1 6.6 0.1 3.5 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Ribosomal_L29 PF00831.18 CDI82963.1 - 0.67 9.6 21.6 0.56 9.9 0.1 4.8 4 1 0 4 4 4 0 Ribosomal L29 protein GAS PF13851.1 CDI82963.1 - 0.96 8.6 22.9 1.3 8.1 1.0 4.0 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding Phage_GP20 PF06810.6 CDI82963.1 - 1.4 8.2 13.9 0.18 11.2 1.1 3.6 4 0 0 4 4 4 0 Phage minor structural protein GP20 DUF2205 PF10224.4 CDI82963.1 - 1.6 8.3 20.2 2.6 7.6 2.3 4.3 4 0 0 4 4 4 0 Predicted coiled-coil protein (DUF2205) TPR_MLP1_2 PF07926.7 CDI82963.1 - 1.8 8.2 23.1 1.2 8.9 1.8 3.5 2 2 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIC PF04977.10 CDI82963.1 - 3 7.3 25.1 0.94 9.0 2.5 4.5 4 0 0 4 4 4 0 Septum formation initiator Flg_hook PF02120.11 CDI82963.1 - 3.3 7.4 6.8 1.2 8.8 0.6 3.0 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK Mnd1 PF03962.10 CDI82963.1 - 3.8 7.1 21.0 1.1 8.8 4.4 3.3 2 2 0 2 2 2 0 Mnd1 family DUF904 PF06005.7 CDI82963.1 - 4.4 7.6 26.0 2.2 8.6 4.9 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF904) bZIP_Maf PF03131.12 CDI82963.1 - 7.8 6.8 19.7 8.4 6.7 0.1 4.4 4 1 0 4 4 4 0 bZIP Maf transcription factor TMF_TATA_bd PF12325.3 CDI82963.1 - 9.3 6.0 22.3 1.7 8.4 2.2 4.1 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF3273 PF11677.3 CDI82964.1 - 1.6e-12 47.2 0.3 1.7e-12 47.1 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) DUF2568 PF10823.3 CDI82964.1 - 0.0023 18.0 0.1 0.0027 17.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2568) TFIIS_C PF01096.13 CDI82966.1 - 2.1e-07 30.4 0.5 2.1e-07 30.4 0.3 2.5 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 CDI82966.1 - 1.5e-06 27.7 6.0 1.5e-06 27.7 4.1 2.8 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit IBR PF01485.16 CDI82966.1 - 0.17 11.7 7.6 0.94 9.4 0.5 3.0 2 1 1 3 3 3 0 IBR domain zf-ribbon_3 PF13248.1 CDI82966.1 - 0.21 10.8 7.9 1.9 7.7 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon domain PHD PF00628.24 CDI82966.1 - 0.24 11.1 5.7 7.1 6.4 1.8 3.1 3 1 0 3 3 3 0 PHD-finger DZR PF12773.2 CDI82966.1 - 0.95 9.3 12.0 0.077 12.8 1.8 2.8 2 1 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.1 CDI82966.1 - 1.1 9.5 7.4 1 9.6 0.7 2.5 2 0 0 2 2 2 0 Restriction alleviation protein Lar DNA_ligase_ZBD PF03119.11 CDI82966.1 - 1.9 8.2 5.2 13 5.6 0.1 3.1 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C4_Topoisom PF01396.14 CDI82966.1 - 2.9 7.4 7.1 5.2 6.6 1.4 2.4 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger DUF2296 PF10058.4 CDI82966.1 - 3 7.6 5.3 18 5.1 0.0 3.1 3 1 0 3 3 3 0 Predicted integral membrane metal-binding protein (DUF2296) zf-IS66 PF13005.2 CDI82966.1 - 4.4 7.3 6.5 3.5 7.6 0.0 3.0 2 1 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Zn_Tnp_IS1595 PF12760.2 CDI82966.1 - 5.9 6.7 6.9 12 5.7 0.4 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Zn_ribbon_recom PF13408.1 CDI82966.1 - 9.2 6.6 7.3 0.96 9.7 0.4 2.5 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain DUF2387 PF09526.5 CDI82966.1 - 9.9 6.1 7.3 5.9 6.8 0.1 2.7 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) TRAUB PF08164.7 CDI82970.1 - 4.1e-10 39.6 0.0 4.1e-10 39.6 0.0 3.5 2 1 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal Glyco_hydro_38 PF01074.17 CDI82970.1 - 0.039 13.1 0.7 0.066 12.4 0.5 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 N-terminal domain PAT1 PF09770.4 CDI82970.1 - 0.24 9.6 22.8 0.33 9.1 15.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.12 CDI82970.1 - 2.9 6.6 9.0 0.6 8.8 2.8 1.9 2 0 0 2 2 2 0 Presenilin AbiH PF14253.1 CDI82971.1 - 0.097 12.2 4.5 2.2 7.8 0.3 2.2 2 0 0 2 2 2 0 Bacteriophage abortive infection AbiH GrpE PF01025.14 CDI82972.1 - 1.5e-41 141.7 15.1 3.1e-41 140.6 10.5 1.6 1 1 0 1 1 1 1 GrpE DUF904 PF06005.7 CDI82972.1 - 0.0071 16.6 5.1 0.0071 16.6 3.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF904) IncA PF04156.9 CDI82972.1 - 0.01 15.4 25.0 0.014 15.0 17.3 1.2 1 0 0 1 1 1 0 IncA protein DUF1664 PF07889.7 CDI82972.1 - 0.012 15.3 1.3 0.012 15.3 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) WD-3 PF09765.4 CDI82972.1 - 0.27 10.4 3.3 0.4 9.9 2.3 1.2 1 0 0 1 1 1 0 WD-repeat region T4SS PF07996.6 CDI82972.1 - 0.32 10.8 26.7 0.15 11.9 8.3 2.3 2 0 0 2 2 2 0 Type IV secretion system proteins Rabaptin PF03528.10 CDI82972.1 - 0.4 10.6 17.0 1.9 8.4 5.4 2.3 2 0 0 2 2 2 0 Rabaptin Laminin_II PF06009.7 CDI82972.1 - 0.51 10.0 16.1 0.55 9.9 9.6 1.9 1 1 1 2 2 2 0 Laminin Domain II AAA_13 PF13166.1 CDI82972.1 - 0.68 8.3 13.7 0.9 7.9 9.5 1.1 1 0 0 1 1 1 0 AAA domain DDE_Tnp_IS240 PF13610.1 CDI82972.1 - 1 9.2 6.9 3.2 7.7 1.7 2.3 1 1 1 2 2 2 0 DDE domain COG2 PF06148.6 CDI82972.1 - 1.8 8.4 13.8 0.87 9.4 3.5 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Adaptin_binding PF10199.4 CDI82972.1 - 2.1 8.6 19.7 0.024 14.9 2.0 2.2 1 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF2201_N PF13203.1 CDI82972.1 - 2.3 7.3 14.1 4.4 6.3 9.8 1.5 1 0 0 1 1 1 0 Putative metallopeptidase domain USP8_interact PF08941.5 CDI82972.1 - 2.6 7.3 5.5 2.1 7.6 1.9 1.9 2 0 0 2 2 2 0 USP8 interacting DUF972 PF06156.8 CDI82972.1 - 2.9 8.2 18.4 1.6 9.1 2.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Cauli_AT PF03233.8 CDI82972.1 - 3.9 7.1 6.1 4.8 6.8 0.4 2.2 2 0 0 2 2 2 0 Aphid transmission protein DUF4404 PF14357.1 CDI82972.1 - 4.9 7.6 18.0 4 7.9 2.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) T2SF PF00482.18 CDI82972.1 - 5.1 7.0 12.9 0.7 9.8 5.3 2.1 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F PLRV_ORF5 PF01690.12 CDI82972.1 - 5.4 6.0 13.6 7.1 5.6 9.4 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF1423 PF07227.6 CDI82972.1 - 9 4.8 14.6 12 4.4 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) SIP PF04954.8 CDI82973.1 - 0.0091 16.3 0.0 0.013 15.8 0.0 1.4 1 1 0 1 1 1 1 Siderophore-interacting protein Ubie_methyltran PF01209.13 CDI82978.1 - 9.5e-63 211.4 0.0 1.8e-44 151.5 0.0 3.3 3 1 0 3 3 3 3 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 CDI82978.1 - 2.6e-13 50.2 0.1 3.4e-11 43.4 0.0 3.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDI82978.1 - 2.5e-10 40.2 0.0 5.1e-10 39.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI82978.1 - 3.3e-09 36.5 0.3 0.0011 18.5 0.0 3.5 2 1 2 4 4 4 3 Methyltransferase domain Methyltransf_12 PF08242.7 CDI82978.1 - 8.1e-08 32.6 0.0 2e-05 25.0 0.0 2.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI82978.1 - 8.4e-08 32.5 0.2 5.2e-06 26.7 0.1 3.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI82978.1 - 4.7e-05 23.9 0.0 0.002 18.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI82978.1 - 0.00084 19.3 0.0 0.0023 17.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DUF3512 PF12024.3 CDI82978.1 - 0.0029 16.9 1.5 0.0042 16.4 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) Med15 PF09606.5 CDI82978.1 - 0.0035 15.6 28.2 0.0047 15.2 19.6 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.3 CDI82978.1 - 0.01 15.2 1.3 0.013 14.9 0.9 1.2 1 0 0 1 1 1 1 Spt20 family FHIPEP PF00771.15 CDI82978.1 - 0.063 11.6 0.5 0.082 11.2 0.3 1.1 1 0 0 1 1 1 0 FHIPEP family eIF-3_zeta PF05091.7 CDI82978.1 - 0.084 11.4 3.7 0.11 11.1 2.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Suf PF05843.9 CDI82978.1 - 0.16 11.6 5.2 0.21 11.2 3.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Activator_LAG-3 PF11498.3 CDI82978.1 - 0.17 10.5 24.4 0.24 10.0 16.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF1840 PF08895.6 CDI82978.1 - 0.18 11.8 6.9 2.3 8.2 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Ufd2P_core PF10408.4 CDI82978.1 - 0.3 9.2 3.8 0.38 8.9 2.7 1.1 1 0 0 1 1 1 0 Ubiquitin elongating factor core DUF4175 PF13779.1 CDI82978.1 - 0.34 8.5 21.3 0.44 8.1 14.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FimP PF09766.4 CDI82978.1 - 0.5 9.3 12.4 0.7 8.9 8.6 1.1 1 0 0 1 1 1 0 Fms-interacting protein Serinc PF03348.10 CDI82978.1 - 0.88 8.2 2.4 1.2 7.7 1.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4199 PF13858.1 CDI82978.1 - 0.92 9.4 2.6 1.5 8.7 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) RED_N PF07808.8 CDI82978.1 - 1 8.5 9.7 1.5 7.9 6.7 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF4557 PF15101.1 CDI82978.1 - 3.7 7.3 12.3 5.4 6.7 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) UPF0560 PF10577.4 CDI82978.1 - 5.5 5.1 10.0 7.4 4.7 6.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SIS PF01380.17 CDI82980.1 - 8.5e-33 112.7 0.2 6.9e-18 64.5 0.0 2.8 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.1 CDI82980.1 - 3.1e-21 75.7 0.0 6.4e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 CDI82980.1 - 4.5e-18 65.1 0.0 9.3e-18 64.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 CDI82980.1 - 6.3e-15 54.7 0.3 1e-12 47.5 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_4 PF13230.1 CDI82980.1 - 2.9e-07 29.4 0.2 5.6e-07 28.5 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II LRR_4 PF12799.2 CDI82981.1 - 9.6e-16 57.0 14.4 2.8e-07 29.9 0.0 3.9 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CDI82981.1 - 7e-11 40.6 16.3 0.35 11.0 0.3 6.7 5 2 1 6 6 6 5 Leucine Rich Repeat LRR_8 PF13855.1 CDI82981.1 - 2.8e-08 33.3 13.2 0.0012 18.5 0.3 3.7 2 1 1 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 CDI82981.1 - 6.4e-07 28.5 18.2 0.72 10.3 0.1 7.1 7 0 0 7 7 7 3 Leucine rich repeat LRR_6 PF13516.1 CDI82981.1 - 1.7e-06 27.4 13.1 5.5 7.3 0.0 6.6 6 1 0 6 6 6 4 Leucine Rich repeat LRR_9 PF14580.1 CDI82981.1 - 0.00058 19.4 0.9 0.0024 17.4 0.3 1.9 1 1 0 2 2 2 1 Leucine-rich repeat Kelch_3 PF13415.1 CDI82985.1 - 3.9e-07 30.0 0.1 1.9e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI82985.1 - 1.2e-06 28.3 0.8 6.6e-06 25.9 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 CDI82985.1 - 3.1e-05 23.6 0.1 0.00012 21.7 0.0 1.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 CDI82985.1 - 0.00011 21.7 0.1 0.00017 21.0 0.1 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.10 CDI82985.1 - 0.014 15.0 0.2 0.023 14.4 0.1 1.3 1 0 0 1 1 1 0 Kelch motif DUF1373 PF07117.6 CDI82990.1 - 0.054 13.2 4.3 0.07 12.8 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1373) Daxx PF03344.10 CDI82994.1 - 0.022 13.2 11.0 0.0054 15.2 4.2 2.0 2 0 0 2 2 2 0 Daxx Family Suf PF05843.9 CDI82994.1 - 9.3 5.8 13.0 0.39 10.4 0.3 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PrsW-protease PF13367.1 CDI82995.1 - 2.5e-15 56.1 10.9 2.3e-12 46.5 3.1 4.0 4 0 0 4 4 4 3 Protease prsW family Ribosomal_L28e PF01778.12 CDI82996.1 - 2.1e-27 95.8 3.2 2.1e-27 95.8 2.2 2.6 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.9 CDI82996.1 - 3.4e-14 52.7 10.6 3.4e-14 52.7 7.3 2.9 1 1 1 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L18e PF00828.14 CDI82997.1 - 1.6e-22 80.2 0.0 2.3e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 AP2 PF00847.15 CDI82998.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.6 2 1 1 3 3 3 0 AP2 domain Band_3_cyto PF07565.8 CDI82998.1 - 0.035 13.6 18.1 0.22 10.9 2.4 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Tom37_C PF11801.3 CDI82998.1 - 0.056 13.3 19.1 0.15 11.8 1.5 2.3 2 0 0 2 2 2 0 Tom37 C-terminal domain DUF3332 PF11810.3 CDI82998.1 - 1.9 8.1 14.0 1.6 8.3 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3332) DUF4011 PF13195.1 CDI82998.1 - 2.5 8.1 11.8 1.6 8.7 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4011) AAA_11 PF13086.1 CDI82998.1 - 3.3 7.2 23.0 1.5 8.3 2.5 2.2 2 0 0 2 2 2 0 AAA domain DUF607 PF04678.8 CDI82998.1 - 7.9 6.3 17.3 8.3 6.3 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF607 Fibrillarin PF01269.12 CDI82999.1 - 1.3e-110 367.7 0.0 1.7e-110 367.4 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 CDI82999.1 - 0.0004 19.9 0.0 0.0006 19.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 CDI82999.1 - 0.0011 18.5 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI82999.1 - 0.068 13.7 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.7 CDI82999.1 - 0.17 10.7 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase AAA_16 PF13191.1 CDI83006.1 - 4.5e-07 30.0 1.3 4.5e-07 30.0 0.9 2.8 4 0 0 4 4 4 1 AAA ATPase domain AAA_29 PF13555.1 CDI83006.1 - 0.0036 16.8 0.3 0.0093 15.4 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 CDI83006.1 - 0.032 14.5 0.2 0.082 13.2 0.2 1.6 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 CDI83006.1 - 0.077 13.3 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CDI83006.1 - 0.13 11.9 0.1 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CDI83006.1 - 0.17 12.1 0.1 0.64 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 CDI83006.1 - 2.9 7.7 7.7 0.15 11.9 0.2 2.8 3 1 0 3 3 3 0 AAA domain Bromodomain PF00439.20 CDI83007.1 - 0.00079 19.3 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Cnd3 PF12719.2 CDI83007.1 - 0.27 10.1 0.2 0.43 9.5 0.1 1.2 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain DEAD PF00270.24 CDI83008.1 - 3.4e-42 143.8 0.1 6.9e-42 142.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 CDI83008.1 - 1.1e-20 72.9 0.2 2e-20 72.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 CDI83008.1 - 4.2e-06 26.5 0.1 4.5e-05 23.2 0.1 2.6 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI83008.1 - 0.043 13.6 0.0 0.12 12.1 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Trichoplein PF13868.1 CDI83009.1 - 6.3e-19 67.5 125.9 1.3e-14 53.4 45.7 2.9 2 1 1 3 3 3 2 Tumour suppressor, Mitostatin CPSase_sm_chain PF00988.17 CDI83009.1 - 0.023 14.2 1.9 0.063 12.7 0.3 2.2 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase small chain, CPSase domain ELO PF01151.13 CDI83011.1 - 3.9e-49 167.2 21.0 4.8e-49 166.9 14.5 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family zf-MYND PF01753.13 CDI83012.1 - 0.00012 21.9 7.2 0.00031 20.5 5.0 1.8 1 0 0 1 1 1 1 MYND finger PAS_3 PF08447.6 CDI83016.1 - 0.014 15.4 0.0 1 9.4 0.0 2.3 2 0 0 2 2 2 0 PAS fold PAS_9 PF13426.1 CDI83016.1 - 0.056 13.8 0.0 0.24 11.7 0.0 2.1 3 0 0 3 3 3 0 PAS domain Ank PF00023.25 CDI83017.1 - 4.8e-18 63.9 0.8 8.6e-09 34.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CDI83017.1 - 2.6e-17 62.4 0.7 5.3e-10 39.2 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDI83017.1 - 5.8e-17 61.8 1.1 9e-17 61.2 0.2 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CDI83017.1 - 4e-12 45.1 0.7 3e-05 23.8 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 CDI83017.1 - 9.9e-12 45.0 0.1 1.7e-07 31.5 0.0 4.0 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Neur_chan_memb PF02932.11 CDI83018.1 - 0.072 12.9 0.9 1.7 8.4 0.0 2.8 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PseudoU_synth_2 PF00849.17 CDI83019.1 - 5.3e-27 94.6 0.0 6.5e-26 91.1 0.0 2.1 1 1 0 1 1 1 1 RNA pseudouridylate synthase AAA_19 PF13245.1 CDI83019.1 - 0.027 14.2 0.2 6.5 6.5 0.0 3.0 3 0 0 3 3 3 0 Part of AAA domain DUF3037 PF11236.3 CDI83020.1 - 0.086 12.9 0.1 0.3 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) DUF1943 PF09172.6 CDI83020.1 - 0.51 9.1 3.0 0.86 8.4 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF2964 PF11177.3 CDI83025.1 - 0.061 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2964) gp12-short_mid PF09089.5 CDI83028.1 - 0.066 13.1 0.2 0.066 13.1 0.1 2.7 3 0 0 3 3 3 0 Phage short tail fibre protein gp12, middle domain ATP-synt_J PF04911.7 CDI83028.1 - 0.077 12.4 0.0 28 4.2 0.0 3.0 3 0 0 3 3 3 0 ATP synthase j chain LRR19-TM PF15176.1 CDI83028.1 - 0.079 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF3357 PF11837.3 CDI83029.1 - 0.022 14.6 0.0 0.065 13.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) RIC1 PF07064.8 CDI83031.1 - 0.014 14.8 0.1 0.032 13.6 0.0 1.5 1 1 0 1 1 1 0 RIC1 ThiF PF00899.16 CDI83032.1 - 3.3e-34 117.6 0.1 1.3e-11 44.4 0.0 4.9 4 1 1 5 5 5 4 ThiF family UBACT PF02134.16 CDI83032.1 - 1.2e-14 53.5 0.0 1e-10 41.0 0.0 2.8 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 CDI83032.1 - 5.5e-06 25.6 0.2 1.2e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UBA_e1_C PF09358.5 CDI83032.1 - 0.00042 20.4 0.0 0.0012 18.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain 2-Hacid_dh_C PF02826.14 CDI83032.1 - 0.0062 15.7 0.0 1.1 8.4 0.0 2.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CDI83032.1 - 0.022 14.8 0.2 7.2 6.7 0.1 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 CDI83032.1 - 0.035 14.5 0.8 4.9 7.6 0.2 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Apolipoprotein PF01442.13 CDI83033.1 - 2.4e-05 23.9 8.8 3e-05 23.6 4.7 1.8 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain Prefoldin PF02996.12 CDI83033.1 - 0.0006 19.4 5.2 0.0011 18.5 2.2 2.1 2 1 0 2 2 2 1 Prefoldin subunit IL6 PF00489.12 CDI83033.1 - 0.00097 18.7 0.3 0.32 10.5 0.2 2.0 1 1 1 2 2 2 1 Interleukin-6/G-CSF/MGF family CorA PF01544.13 CDI83033.1 - 0.0015 17.6 1.2 0.0017 17.4 0.9 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein AAA_13 PF13166.1 CDI83033.1 - 0.003 16.1 0.6 0.0032 16.0 0.4 1.0 1 0 0 1 1 1 1 AAA domain DUF4456 PF14644.1 CDI83033.1 - 0.003 16.8 0.8 0.0043 16.3 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4456) DUF883 PF05957.8 CDI83033.1 - 0.0031 17.8 6.7 0.0031 17.8 4.7 1.8 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF883) PilJ PF13675.1 CDI83033.1 - 0.0058 16.9 6.6 0.24 11.7 0.2 2.1 1 1 1 2 2 2 2 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4404 PF14357.1 CDI83033.1 - 0.011 16.1 6.6 0.82 10.1 2.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF1664 PF07889.7 CDI83033.1 - 0.012 15.4 2.5 0.02 14.6 1.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Snf7 PF03357.16 CDI83033.1 - 0.012 14.9 3.4 0.045 13.1 2.2 1.7 1 1 1 2 2 2 0 Snf7 Pex19 PF04614.7 CDI83033.1 - 0.019 14.5 3.7 0.034 13.7 2.6 1.4 1 1 0 1 1 1 0 Pex19 protein family Phasin_2 PF09361.5 CDI83033.1 - 0.02 14.8 3.9 0.96 9.5 2.5 2.3 1 1 0 1 1 1 0 Phasin protein LON PF02190.11 CDI83033.1 - 0.03 14.0 0.2 0.034 13.8 0.1 1.1 1 0 0 1 1 1 0 ATP-dependent protease La (LON) domain FUSC PF04632.7 CDI83033.1 - 0.037 12.4 10.9 0.05 12.0 7.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3829 PF12889.2 CDI83033.1 - 0.045 12.9 0.9 0.057 12.6 0.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3829) ATP-synt_B PF00430.13 CDI83033.1 - 0.047 13.4 8.1 0.085 12.6 5.3 1.6 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Nsp1_C PF05064.8 CDI83033.1 - 0.055 13.1 1.9 0.099 12.2 1.3 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region Flu_NS2 PF00601.14 CDI83033.1 - 0.06 13.5 0.0 0.12 12.5 0.1 1.6 2 0 0 2 2 1 0 Influenza non-structural protein (NS2) zf-HC2 PF13490.1 CDI83033.1 - 0.063 13.2 4.3 0.17 11.8 2.1 2.3 2 0 0 2 2 2 0 Putative zinc-finger Activator-TraM PF11657.3 CDI83033.1 - 0.074 12.5 1.3 0.15 11.5 0.4 1.9 1 1 1 2 2 2 0 Transcriptional activator TraM Laminin_II PF06009.7 CDI83033.1 - 0.075 12.7 3.2 0.087 12.5 1.5 1.6 1 1 1 2 2 2 0 Laminin Domain II DUF4618 PF15397.1 CDI83033.1 - 0.08 12.2 3.3 0.3 10.3 2.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Fib_alpha PF08702.5 CDI83033.1 - 0.081 13.0 1.1 0.12 12.5 0.8 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FH2 PF02181.18 CDI83033.1 - 0.087 11.6 0.4 0.1 11.4 0.3 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain COG2 PF06148.6 CDI83033.1 - 0.093 12.6 2.7 0.21 11.4 1.9 1.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.7 CDI83033.1 - 0.097 12.9 3.7 0.17 12.1 2.3 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF848 PF05852.6 CDI83033.1 - 0.11 12.3 5.0 0.16 11.8 3.2 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF3987 PF13148.1 CDI83033.1 - 0.11 11.0 4.0 0.14 10.7 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) ISG65-75 PF11727.3 CDI83033.1 - 0.11 11.5 1.9 0.14 11.1 1.4 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein YkuI_C PF10388.4 CDI83033.1 - 0.12 12.0 0.1 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain CHAD PF05235.9 CDI83033.1 - 0.12 11.9 12.0 0.37 10.3 1.2 2.0 1 1 1 2 2 2 0 CHAD domain Spc7 PF08317.6 CDI83033.1 - 0.12 10.9 1.1 0.17 10.4 0.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YtxH PF12732.2 CDI83033.1 - 0.13 12.6 4.1 0.83 10.0 2.8 2.3 1 1 0 1 1 1 0 YtxH-like protein UPF0184 PF03670.8 CDI83033.1 - 0.15 12.2 1.3 0.24 11.5 0.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Baculo_PEP_C PF04513.7 CDI83033.1 - 0.16 11.7 2.3 0.47 10.2 1.4 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus RTBV_P46 PF06216.6 CDI83033.1 - 0.17 10.7 0.2 0.21 10.4 0.2 1.1 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein VIT1 PF01988.14 CDI83033.1 - 0.18 11.2 1.2 0.2 11.1 0.8 1.1 1 0 0 1 1 1 0 VIT family DUF3584 PF12128.3 CDI83033.1 - 0.2 8.9 6.0 0.22 8.8 4.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) THP2 PF09432.5 CDI83033.1 - 0.22 11.3 1.4 0.36 10.6 1.0 1.3 1 0 0 1 1 1 0 Tho complex subunit THP2 MutS_III PF05192.13 CDI83033.1 - 0.23 11.2 2.2 0.3 10.8 1.5 1.2 1 0 0 1 1 1 0 MutS domain III WXG100 PF06013.7 CDI83033.1 - 0.26 11.2 3.4 1.5 8.8 2.1 2.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG GrpE PF01025.14 CDI83033.1 - 0.29 10.6 4.9 0.45 10.0 3.3 1.4 1 1 0 1 1 1 0 GrpE Rootletin PF15035.1 CDI83033.1 - 0.31 10.9 4.9 0.34 10.8 3.0 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Syntaxin PF00804.20 CDI83033.1 - 0.43 10.7 2.7 0.79 9.9 1.9 1.5 1 1 0 1 1 1 0 Syntaxin DUF4407 PF14362.1 CDI83033.1 - 0.44 9.4 5.3 0.6 9.0 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IncA PF04156.9 CDI83033.1 - 0.52 9.8 6.9 0.79 9.2 4.4 1.6 1 1 0 1 1 1 0 IncA protein ApoLp-III PF07464.6 CDI83033.1 - 0.65 10.0 6.4 0.92 9.5 3.8 1.7 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF2605 PF10792.4 CDI83033.1 - 0.69 9.6 3.0 0.57 9.8 1.2 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2605) SpaB_C PF14028.1 CDI83033.1 - 0.71 9.3 9.0 0.82 9.1 6.2 1.1 1 0 0 1 1 1 0 SpaB C-terminal domain CK2S PF15011.1 CDI83033.1 - 0.77 9.5 5.6 2 8.2 2.2 2.0 1 1 1 2 2 2 0 Casein Kinase 2 substrate Peripla_BP_2 PF01497.13 CDI83033.1 - 0.78 8.8 5.2 5.8 5.9 3.6 2.1 1 1 0 1 1 1 0 Periplasmic binding protein PspA_IM30 PF04012.7 CDI83033.1 - 0.98 8.7 13.3 0.83 8.9 6.7 1.7 1 1 0 1 1 1 0 PspA/IM30 family HSCB_C PF07743.8 CDI83033.1 - 1.5 9.3 9.7 2.9 8.4 0.5 2.4 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain COMP PF11598.3 CDI83033.1 - 2 8.5 3.9 3.7 7.7 2.4 1.8 1 1 0 1 1 1 0 Cartilage oligomeric matrix protein FlgN PF05130.7 CDI83033.1 - 2.1 8.5 9.1 3.1 8.0 6.3 1.3 1 0 0 1 1 1 0 FlgN protein OmpH PF03938.9 CDI83033.1 - 2.9 7.8 11.5 4.8 7.0 7.9 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FliT PF05400.8 CDI83033.1 - 3.3 8.1 14.2 31 5.0 9.4 2.2 1 1 1 2 2 2 0 Flagellar protein FliT DUF4140 PF13600.1 CDI83033.1 - 4.9 7.6 8.2 9.1 6.7 4.5 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) PAT1 PF09770.4 CDI83036.1 - 0.00012 20.4 22.6 0.00013 20.4 15.6 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 FimP PF09766.4 CDI83036.1 - 0.059 12.4 20.9 0.081 11.9 14.5 1.2 1 0 0 1 1 1 0 Fms-interacting protein Spore_coat_CotO PF14153.1 CDI83036.1 - 0.096 12.1 17.5 0.13 11.7 12.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO SAPS PF04499.10 CDI83036.1 - 0.16 10.5 8.7 0.15 10.6 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Macoilin PF09726.4 CDI83036.1 - 0.25 9.5 15.7 0.3 9.3 10.9 1.1 1 0 0 1 1 1 0 Transmembrane protein Ycf1 PF05758.7 CDI83036.1 - 0.67 7.6 10.5 0.7 7.5 7.3 1.0 1 0 0 1 1 1 0 Ycf1 RED_N PF07808.8 CDI83036.1 - 0.9 8.7 16.0 1.4 8.0 11.1 1.5 1 0 0 1 1 1 0 RED-like protein N-terminal region Gag_spuma PF03276.9 CDI83036.1 - 1.3 7.2 26.3 1.6 6.9 18.2 1.3 1 0 0 1 1 1 0 Spumavirus gag protein CDC45 PF02724.9 CDI83036.1 - 1.5 6.8 16.2 1.8 6.5 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Suf PF05843.9 CDI83036.1 - 1.9 8.1 18.6 2.5 7.7 12.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Endonuc_Holl PF10107.4 CDI83036.1 - 2.6 7.7 11.7 4.1 7.0 8.1 1.4 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF966 PF06136.8 CDI83036.1 - 2.7 7.3 18.4 3 7.1 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Dehydrin PF00257.14 CDI83036.1 - 2.7 8.3 25.0 3.4 7.9 16.5 1.7 1 1 1 2 2 2 0 Dehydrin Peptidase_S49_N PF08496.5 CDI83036.1 - 3.2 7.5 9.8 4.9 6.9 6.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Activator_LAG-3 PF11498.3 CDI83036.1 - 4.7 5.8 44.2 6.6 5.3 30.7 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Plasmodium_Vir PF05795.6 CDI83036.1 - 6.1 5.9 7.0 7.6 5.6 4.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Glyco_transf_15 PF01793.11 CDI83036.1 - 6.2 5.6 11.4 8 5.2 7.9 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase eIF-3_zeta PF05091.7 CDI83036.1 - 7.3 5.0 17.1 9 4.7 11.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Actin PF00022.14 CDI83042.1 - 4.8e-75 252.4 0.0 2e-59 201.0 0.0 2.0 1 1 1 2 2 2 2 Actin YajC PF02699.10 CDI83042.1 - 1 9.0 4.6 2.8 7.6 3.2 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit RCC1 PF00415.13 CDI83043.1 - 1.6e-67 223.4 42.8 2.6e-13 49.9 0.2 11.4 12 1 0 12 12 12 9 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI83043.1 - 4.7e-33 112.0 57.5 2.5e-07 30.1 0.5 9.4 9 0 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat DUF501 PF04417.7 CDI83045.1 - 6.3 6.6 7.6 7 6.4 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF501) UPF1_Zn_bind PF09416.5 CDI83045.1 - 7 6.2 9.6 8.8 5.8 6.7 1.1 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) SRPRB PF09439.5 CDI83046.1 - 4e-15 55.4 0.0 5.2e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 CDI83046.1 - 7.7e-07 28.7 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 CDI83046.1 - 1e-05 24.8 0.0 1.4e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.13 CDI83046.1 - 0.089 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B Ribosomal_S9 PF00380.14 CDI83048.1 - 2.3e-19 69.8 0.0 2.3e-19 69.8 0.0 2.8 3 0 0 3 3 3 1 Ribosomal protein S9/S16 Gemini_mov PF01708.11 CDI83048.1 - 0.67 9.5 10.8 0.58 9.7 0.1 4.2 3 0 0 3 3 3 0 Geminivirus putative movement protein LMBR1 PF04791.11 CDI83048.1 - 1 7.8 4.5 1.9 7.0 1.3 2.3 2 0 0 2 2 2 0 LMBR1-like membrane protein DDHD PF02862.12 CDI83048.1 - 3.3 7.4 25.3 0.7 9.6 0.8 4.0 4 0 0 4 4 4 0 DDHD domain Plasmodium_Vir PF05795.6 CDI83048.1 - 9.8 5.2 9.0 4.9 6.2 0.1 3.1 3 0 0 3 3 3 0 Plasmodium vivax Vir protein Cwf_Cwc_15 PF04889.7 CDI83048.1 - 9.8 5.8 28.3 0.13 11.9 0.1 4.2 4 0 0 4 4 4 0 Cwf15/Cwc15 cell cycle control protein GTP_EFTU PF00009.22 CDI83049.1 - 3.9e-56 189.4 0.0 5.6e-56 188.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CDI83049.1 - 2.4e-36 123.8 0.1 1.2e-35 121.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CDI83049.1 - 1.3e-17 63.7 0.7 3.5e-17 62.2 0.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 CDI83049.1 - 9e-06 25.2 0.5 3.2e-05 23.4 0.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 CDI83049.1 - 0.00035 20.5 0.0 0.0012 18.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase NIF3 PF01784.13 CDI83049.1 - 0.011 15.3 1.0 0.016 14.7 0.1 1.7 2 0 0 2 2 2 0 NIF3 (NGG1p interacting factor 3) LCM PF04072.9 CDI83050.1 - 0.00014 21.5 0.1 0.00015 21.4 0.1 1.1 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase DUF1512 PF07431.7 CDI83053.1 - 0.14 10.8 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) Sec23_trunk PF04811.10 CDI83054.1 - 2.9e-21 75.9 0.0 6.7e-21 74.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CDI83054.1 - 2.4e-15 55.8 0.1 6.8e-15 54.3 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 CDI83054.1 - 1.8e-10 40.1 3.2 3.4e-10 39.3 2.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 CDI83054.1 - 0.013 15.9 0.0 0.073 13.5 0.0 2.3 2 0 0 2 2 2 0 Sec23/Sec24 beta-sandwich domain Peptidase_M18 PF02127.10 CDI83055.1 - 9.7e-90 301.1 0.0 3.6e-53 180.6 0.0 3.0 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 CDI83055.1 - 7.5e-07 28.1 0.0 3.2e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase DUF3333 PF11812.3 CDI83055.1 - 0.15 12.0 0.0 0.56 10.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) Actin PF00022.14 CDI83056.1 - 7e-28 97.1 0.0 7e-17 60.9 0.0 2.4 2 1 0 2 2 2 2 Actin PPR_2 PF13041.1 CDI83058.1 - 8.2e-51 169.7 5.8 5.9e-15 54.9 0.0 7.3 3 1 4 7 7 7 6 PPR repeat family PPR PF01535.15 CDI83058.1 - 8.6e-39 128.8 8.4 3e-06 26.8 0.0 8.9 8 1 1 9 9 9 8 PPR repeat PPR_3 PF13812.1 CDI83058.1 - 5.8e-38 125.9 6.2 4.2e-06 26.5 0.0 9.5 8 1 1 9 9 9 7 Pentatricopeptide repeat domain PPR_1 PF12854.2 CDI83058.1 - 2.6e-30 103.5 0.2 2.1e-08 33.4 0.0 6.7 6 0 0 6 6 6 6 PPR repeat APG6 PF04111.7 CDI83059.1 - 0.0017 17.4 19.0 0.0017 17.4 13.1 7.1 6 2 2 8 8 8 4 Autophagy protein Apg6 HALZ PF02183.13 CDI83059.1 - 0.013 15.2 0.3 0.013 15.2 0.2 12.3 10 3 1 11 11 11 0 Homeobox associated leucine zipper NIF PF03031.13 CDI83064.1 - 1.3e-10 41.1 0.0 1.6e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase HAD_2 PF13419.1 CDI83064.1 - 0.0083 16.3 0.2 1 9.5 0.0 2.6 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Biotin_lipoyl_2 PF13533.1 CDI83064.1 - 0.056 13.1 0.0 0.056 13.1 0.0 3.2 3 1 0 3 3 3 0 Biotin-lipoyl like Suf PF05843.9 CDI83064.1 - 8 6.0 9.6 0.62 9.7 0.5 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) UDPGP PF01704.13 CDI83067.1 - 1.2e-12 47.1 0.0 1.6e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase IPK PF03770.11 CDI83068.1 - 2e-24 86.3 0.0 2e-24 86.3 0.0 4.7 5 0 0 5 5 5 1 Inositol polyphosphate kinase Intimin_C PF07979.6 CDI83069.1 - 0.04 14.1 0.3 0.13 12.4 0.1 1.8 1 1 0 1 1 1 0 Intimin C-type lectin domain MutS_IV PF05190.13 CDI83069.1 - 5.6 7.2 15.2 0.8 9.9 0.2 3.8 2 2 1 3 3 3 0 MutS family domain IV Dus PF01207.12 CDI83070.1 - 3.8e-07 29.2 0.0 3.8e-07 29.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) SpaB_C PF14028.1 CDI83077.1 - 0.012 15.1 6.3 0.015 14.8 4.4 1.2 1 0 0 1 1 1 0 SpaB C-terminal domain Gly-zipper_OmpA PF13436.1 CDI83077.1 - 0.067 12.8 16.8 0.089 12.4 11.7 1.1 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Med3 PF11593.3 CDI83077.1 - 1.7 7.7 11.8 2 7.5 8.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MSP1_C PF07462.6 CDI83077.1 - 4.3 5.6 6.4 4.6 5.5 4.4 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus S1-P1_nuclease PF02265.11 CDI83078.1 - 0.0015 18.1 0.0 0.0015 18.1 0.0 3.4 2 1 0 2 2 2 1 S1/P1 Nuclease PLRV_ORF5 PF01690.12 CDI83078.1 - 2.1 7.3 36.5 2.7 7.0 25.3 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF4647 PF15504.1 CDI83078.1 - 5.6 5.6 36.2 8 5.1 25.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) HTH_36 PF13730.1 CDI83080.1 - 0.018 15.1 0.3 0.32 11.1 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain Herpes_glycop PF01528.11 CDI83080.1 - 0.062 11.9 0.4 0.095 11.3 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Tubulin_C PF03953.12 CDI83082.1 - 2.1e-41 140.8 0.2 4e-41 140.0 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.20 CDI83082.1 - 4e-38 131.4 0.0 5.9e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.1 CDI83082.1 - 0.1 11.5 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Glycos_transf_3 PF00591.16 CDI83083.1 - 0.12 11.7 1.2 0.14 11.5 0.8 1.1 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Nop14 PF04147.7 CDI83084.1 - 2.8 5.7 19.3 3.7 5.3 13.4 1.2 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.5 CDI83084.1 - 4 6.5 16.6 6.4 5.8 11.5 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ribosomal_60s PF00428.14 CDI83086.1 - 5.3 7.5 14.9 1.4 9.3 7.9 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2367 PF10164.4 CDI83093.1 - 0.029 14.2 1.1 0.05 13.4 0.7 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) DUF966 PF06136.8 CDI83094.1 - 0.00052 19.5 12.6 0.00072 19.0 8.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF966) Pyr_redox_2 PF07992.9 CDI83094.1 - 0.0062 16.4 0.0 0.014 15.3 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Spt20 PF12090.3 CDI83094.1 - 0.13 11.6 0.1 0.13 11.6 0.1 2.8 3 0 0 3 3 3 0 Spt20 family Neur_chan_memb PF02932.11 CDI83094.1 - 3.1 7.6 17.4 0.54 10.0 1.7 2.5 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Draxin PF15550.1 CDI83094.1 - 5.3 6.6 26.7 3.8 7.0 6.0 2.1 2 0 0 2 2 2 0 Draxin MutS_III PF05192.13 CDI83097.1 - 1.9e-19 70.2 0.3 6.9e-19 68.4 0.2 1.8 1 1 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 CDI83097.1 - 0.089 12.9 2.6 0.21 11.7 0.1 2.7 4 0 0 4 4 4 0 MutS family domain IV PIG-Y PF15159.1 CDI83099.1 - 1.7e-12 47.3 5.6 2.2e-12 47.0 3.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1464 PF07318.7 CDI83100.1 - 9.1 4.9 8.7 0.12 11.1 0.1 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1464) Gpi16 PF04113.9 CDI83101.1 - 1.3e-16 59.7 3.6 1e-15 56.8 2.6 2.5 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Activator_LAG-3 PF11498.3 CDI83101.1 - 0.0011 17.8 10.6 0.0011 17.8 7.4 7.1 7 0 0 7 7 7 1 Transcriptional activator LAG-3 Otopetrin PF03189.8 CDI83101.1 - 0.012 14.5 0.6 0.026 13.5 0.4 1.4 1 0 0 1 1 1 0 Otopetrin RAP1 PF07218.6 CDI83101.1 - 4.2 5.3 8.2 6.4 4.7 5.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Serinc PF03348.10 CDI83101.1 - 4.5 5.8 7.3 15 4.1 5.1 1.8 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_C2 PF00648.16 CDI83102.1 - 1e-28 100.2 0.2 7.3e-25 87.5 0.0 3.4 3 1 0 3 3 3 2 Calpain family cysteine protease Calpain_III PF01067.17 CDI83102.1 - 6e-08 32.4 9.9 1.6e-06 27.8 0.0 3.7 4 0 0 4 4 4 2 Calpain large subunit, domain III MAR_sialic_bdg PF10564.4 CDI83106.1 - 1.8e-77 255.3 34.8 2.9e-21 75.0 2.1 4.6 5 0 0 5 5 5 4 Sialic-acid binding micronemal adhesive repeat DUF2807 PF10988.3 CDI83106.1 - 0.015 14.8 0.0 66 2.9 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2807) DSL PF01414.14 CDI83106.1 - 0.076 13.0 12.3 1.7 8.7 0.2 4.8 4 0 0 4 4 4 0 Delta serrate ligand McyA_C PF12593.3 CDI83106.1 - 0.89 9.3 2.8 59 3.5 0.0 3.8 4 0 0 4 4 4 0 Microcystin synthetase C terminal SOBP PF15279.1 CDI83107.1 - 0.47 10.7 8.7 0.52 10.6 6.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3499 PF12005.3 CDI83107.1 - 0.78 9.9 3.4 2.3 8.3 2.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) Med15 PF09606.5 CDI83107.1 - 5 5.1 24.5 5.4 5.0 17.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.3 CDI83108.1 - 0.047 12.4 38.3 0.13 10.9 26.5 1.8 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4557 PF15101.1 CDI83108.1 - 0.66 9.7 15.7 2.7 7.7 10.9 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) WD40 PF00400.27 CDI83110.1 - 0.00022 20.9 0.7 7.1 6.6 0.0 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat PUF PF00806.14 CDI83111.1 - 4e-45 148.7 1.4 9.1e-07 28.0 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat PWI PF01480.12 CDI83111.1 - 0.27 11.3 2.1 2.2 8.4 0.4 2.9 2 0 0 2 2 2 0 PWI domain DUF4184 PF13803.1 CDI83111.1 - 0.43 9.8 3.8 1.5 8.0 2.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4184) Pkinase PF00069.20 CDI83112.1 - 8.5e-41 139.8 0.0 3e-26 92.1 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83112.1 - 8e-19 67.7 0.0 7e-13 48.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDI83112.1 - 6.1e-06 25.4 0.0 0.057 12.3 0.0 2.8 3 0 0 3 3 3 2 Kinase-like APH PF01636.18 CDI83112.1 - 9.9e-05 22.1 0.2 9.9e-05 22.1 0.2 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 CDI83112.1 - 0.00017 20.7 0.5 0.00017 20.7 0.4 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF318 PF03773.8 CDI83112.1 - 0.14 11.1 0.1 0.25 10.3 0.1 1.3 1 0 0 1 1 1 0 Predicted permease S1 PF00575.18 CDI83113.1 - 0.16 12.0 0.1 0.48 10.5 0.1 1.8 1 0 0 1 1 1 0 S1 RNA binding domain DOPA_dioxygen PF08883.6 CDI83115.1 - 0.016 15.2 0.7 0.022 14.8 0.5 1.2 1 0 0 1 1 1 0 Dopa 4,5-dioxygenase family UvrD_C_2 PF13538.1 CDI83115.1 - 0.022 14.9 0.6 0.025 14.7 0.4 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF1054 PF06335.7 CDI83115.1 - 0.069 12.8 4.3 0.078 12.6 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) Med3 PF11593.3 CDI83115.1 - 0.26 10.4 6.8 0.3 10.3 4.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ATP-synt_E PF05680.7 CDI83115.1 - 2.2 8.3 7.4 2.7 8.0 5.2 1.2 1 0 0 1 1 1 0 ATP synthase E chain CBFD_NFYB_HMF PF00808.18 CDI83117.1 - 0.057 13.4 1.0 0.1 12.6 0.2 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TACC PF05010.9 CDI83117.1 - 0.074 12.8 1.6 0.096 12.4 1.1 1.3 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) SR-25 PF10500.4 CDI83121.1 - 0.012 15.1 14.4 0.016 14.7 10.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CAF-1_p150 PF11600.3 CDI83121.1 - 0.039 13.3 16.7 0.047 13.0 11.6 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3446 PF11928.3 CDI83121.1 - 0.041 14.0 3.0 0.066 13.4 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) Corona_nucleoca PF00937.13 CDI83121.1 - 1.5 7.6 18.1 1.8 7.4 12.5 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Dsh_C PF12316.3 CDI83121.1 - 1.8 8.6 9.6 2.2 8.3 6.7 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF1117 PF06547.7 CDI83121.1 - 2.3 8.3 6.0 1.3 9.1 2.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1117) Hid1 PF12722.2 CDI83121.1 - 3.3 5.2 11.8 3.5 5.1 8.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spt5_N PF11942.3 CDI83121.1 - 4.6 7.9 8.2 11 6.6 5.7 1.6 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Spt20 PF12090.3 CDI83123.1 - 3.6 6.8 5.6 9.6 5.5 0.2 2.4 2 0 0 2 2 2 0 Spt20 family Pex14_N PF04695.8 CDI83124.1 - 0.001 19.1 7.4 0.0014 18.6 5.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4175 PF13779.1 CDI83124.1 - 0.0073 14.0 21.5 0.0079 13.9 14.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Mre11_DNA_bind PF04152.9 CDI83124.1 - 0.029 14.2 1.8 0.037 13.9 1.2 1.1 1 0 0 1 1 1 0 Mre11 DNA-binding presumed domain EIIBC-GUT_N PF03612.9 CDI83124.1 - 0.043 13.4 1.3 0.048 13.2 0.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Med15 PF09606.5 CDI83124.1 - 0.067 11.3 28.4 0.069 11.3 19.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI83124.1 - 0.069 12.8 7.9 0.077 12.7 5.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TMEM51 PF15345.1 CDI83124.1 - 0.086 12.5 4.6 0.11 12.1 3.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Host_attach PF10116.4 CDI83124.1 - 0.21 11.8 5.1 0.26 11.5 3.6 1.2 1 0 0 1 1 1 0 Protein required for attachment to host cells Band_3_cyto PF07565.8 CDI83124.1 - 0.22 11.0 4.9 0.25 10.8 3.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RED_N PF07808.8 CDI83124.1 - 0.24 10.5 9.2 0.3 10.2 6.3 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF912 PF06024.7 CDI83124.1 - 0.28 11.2 1.2 0.36 10.8 0.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Serinc PF03348.10 CDI83124.1 - 0.31 9.6 2.4 0.33 9.6 1.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.10 CDI83124.1 - 0.32 11.0 2.1 0.39 10.7 1.5 1.2 1 0 0 1 1 1 0 Ctr copper transporter family PAT1 PF09770.4 CDI83124.1 - 0.33 9.1 19.5 0.35 9.0 13.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FimP PF09766.4 CDI83124.1 - 0.37 9.8 13.3 0.43 9.6 9.2 1.1 1 0 0 1 1 1 0 Fms-interacting protein DUF4557 PF15101.1 CDI83124.1 - 0.59 9.9 13.6 0.72 9.6 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) UPF0560 PF10577.4 CDI83124.1 - 4.1 5.5 11.1 4.4 5.4 7.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Tubulin PF00091.20 CDI83125.1 - 7.1e-13 48.8 0.0 1.3e-12 48.0 0.0 1.3 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Sec1 PF00995.18 CDI83126.1 - 1.5e-86 291.2 0.0 5.5e-85 286.1 0.0 1.9 1 1 1 2 2 2 2 Sec1 family AIRC PF00731.15 CDI83126.1 - 0.018 14.3 0.2 0.042 13.1 0.2 1.6 1 0 0 1 1 1 0 AIR carboxylase Mito_carr PF00153.22 CDI83143.1 - 1.2e-36 124.2 1.9 1.3e-16 60.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PUB PF09409.5 CDI83144.1 - 0.00011 21.8 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 PUB domain EF-hand_1 PF00036.27 CDI83145.1 - 1.8e-27 92.4 4.7 2.4e-07 29.5 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDI83145.1 - 1.5e-25 89.0 1.9 2.6e-12 46.7 0.4 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 CDI83145.1 - 2.6e-25 86.5 0.9 9.1e-07 27.9 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 CDI83145.1 - 4.9e-20 69.5 4.2 0.00074 19.2 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 CDI83145.1 - 7.1e-15 54.3 7.9 1.6e-05 24.4 1.3 4.6 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 CDI83145.1 - 2.6e-09 37.1 0.0 0.00077 19.4 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 CDI83145.1 - 4.7e-05 23.0 2.2 0.13 12.0 0.3 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 CDI83145.1 - 0.00066 19.5 0.1 0.02 14.7 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain Caleosin PF05042.8 CDI83145.1 - 0.076 12.5 0.5 5.1 6.6 0.0 2.9 2 1 2 4 4 4 0 Caleosin related protein VCBS PF13517.1 CDI83145.1 - 0.23 11.8 3.0 0.5 10.7 0.3 2.6 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Dockerin_1 PF00404.13 CDI83145.1 - 4.7 7.0 6.6 6.4 6.6 0.4 3.2 3 0 0 3 3 3 0 Dockerin type I repeat DUF947 PF06102.7 CDI83147.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF947) Glyco_transf_90 PF05686.7 CDI83148.1 - 3.1e-46 157.8 0.0 5e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 90 Thioredoxin PF00085.15 CDI83148.1 - 7e-16 57.7 0.0 1.6e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 CDI83148.1 - 0.00054 20.1 0.1 0.005 17.0 0.0 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 CDI83148.1 - 0.0032 17.0 0.1 0.014 14.9 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.1 CDI83148.1 - 0.0085 16.0 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like FleQ PF06490.6 CDI83152.1 - 0.09 12.9 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ BDV_P40 PF06407.6 CDI83152.1 - 0.095 11.5 0.2 0.099 11.4 0.1 1.1 1 0 0 1 1 1 0 Borna disease virus P40 protein RIO1 PF01163.17 CDI83152.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Sec3_C PF09763.4 CDI83155.1 - 0.062 11.4 3.2 0.075 11.1 2.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 PPP4R2 PF09184.6 CDI83155.1 - 0.66 9.4 5.3 0.87 9.0 3.7 1.1 1 0 0 1 1 1 0 PPP4R2 Macoilin PF09726.4 CDI83155.1 - 2.3 6.3 18.8 3.5 5.8 13.1 1.2 1 0 0 1 1 1 0 Transmembrane protein Secretin_N_2 PF07655.8 CDI83155.1 - 3.9 7.9 19.3 7.6 6.9 13.4 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain DNA_pol_viral_N PF00242.12 CDI83155.1 - 9.8 5.0 11.0 13 4.6 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain AAA PF00004.24 CDI83156.1 - 6.1e-17 62.0 0.0 8.4e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI83156.1 - 1.4e-07 31.3 0.0 2.3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDI83156.1 - 1.7e-06 28.1 0.0 5.9e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDI83156.1 - 6.1e-06 27.0 0.0 7.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 CDI83156.1 - 6.3e-06 26.2 0.0 1.6e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CDI83156.1 - 3.6e-05 23.8 0.1 0.00011 22.2 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 CDI83156.1 - 0.00012 21.4 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein MobB PF03205.9 CDI83156.1 - 0.00055 19.6 0.0 0.0008 19.1 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 CDI83156.1 - 0.00083 19.2 0.0 0.001 18.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDI83156.1 - 0.00084 19.2 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CDI83156.1 - 0.00093 18.7 0.0 0.0011 18.4 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain NTPase_1 PF03266.10 CDI83156.1 - 0.0013 18.4 0.1 0.021 14.5 0.0 2.0 1 1 1 2 2 2 1 NTPase AAA_18 PF13238.1 CDI83156.1 - 0.0025 18.0 0.0 0.0028 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CDI83156.1 - 0.0036 17.4 0.0 0.0049 17.0 0.0 1.3 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.7 CDI83156.1 - 0.0045 16.6 0.0 0.0095 15.6 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_3 PF07726.6 CDI83156.1 - 0.0055 16.3 0.0 0.012 15.1 0.0 1.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDI83156.1 - 0.0085 15.1 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CDI83156.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_24 PF13479.1 CDI83156.1 - 0.016 14.7 0.1 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 CDI83156.1 - 0.039 13.1 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_25 PF13481.1 CDI83156.1 - 0.044 13.1 0.0 0.074 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDI83156.1 - 0.08 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_28 PF13521.1 CDI83156.1 - 0.087 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDI83156.1 - 0.088 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.22 CDI83156.1 - 0.093 13.0 0.0 0.19 12.0 0.0 1.3 1 1 0 1 1 1 0 ABC transporter CbiA PF01656.18 CDI83156.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.17 CDI83156.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.1 CDI83156.1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 CDI83156.1 - 0.12 11.1 0.0 1.4 7.7 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain Arch_ATPase PF01637.13 CDI83156.1 - 0.13 11.9 0.2 2.1 8.0 0.0 2.0 1 1 0 2 2 2 0 Archaeal ATPase ADK PF00406.17 CDI83156.1 - 0.15 11.9 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Adenylate kinase tRNA_anti-codon PF01336.20 CDI83163.1 - 3.3e-08 33.2 0.0 3.6e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain TSA PF03249.8 CDI83163.1 - 0.0035 15.9 3.1 0.0059 15.2 2.1 1.3 1 0 0 1 1 1 1 Type specific antigen Rep_fac-A_C PF08646.5 CDI83163.1 - 0.03 14.0 1.0 0.51 10.0 0.0 2.6 3 0 0 3 3 3 0 Replication factor-A C terminal domain Pantoate_transf PF02548.10 CDI83164.1 - 1.5e-42 145.5 6.4 3.6e-24 85.3 3.4 3.7 2 1 0 2 2 2 2 Ketopantoate hydroxymethyltransferase ApbA_C PF08546.6 CDI83164.1 - 9.2e-25 87.0 0.1 2e-24 85.9 0.1 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Fucose_iso_C PF02952.12 CDI83164.1 - 0.093 12.2 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain G6PD_C PF02781.11 CDI83165.1 - 2.7e-52 177.4 0.0 4.8e-41 140.5 0.0 3.0 1 1 1 2 2 2 2 Glucose-6-phosphate dehydrogenase, C-terminal domain Glucosamine_iso PF01182.15 CDI83165.1 - 1.3e-31 109.8 0.0 2.3e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_N PF00479.17 CDI83165.1 - 3.5e-20 72.9 0.0 8.3e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain TIP49 PF06068.8 CDI83166.1 - 2e-178 593.1 0.0 2.4e-178 592.9 0.0 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 CDI83166.1 - 8e-13 48.7 0.0 9.8e-09 35.5 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDI83166.1 - 6.6e-11 41.7 2.9 3.7e-07 29.4 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 CDI83166.1 - 2.9e-08 33.9 0.1 0.0031 17.5 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 CDI83166.1 - 4.2e-07 30.1 0.0 0.025 14.7 0.0 3.1 2 1 0 3 3 3 2 AAA domain AAA_5 PF07728.9 CDI83166.1 - 7.7e-06 25.6 0.1 0.0013 18.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 CDI83166.1 - 6.5e-05 22.6 0.0 0.00022 20.8 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 CDI83166.1 - 0.00028 21.7 0.0 0.0011 19.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDI83166.1 - 0.00033 20.1 0.0 0.00062 19.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 CDI83166.1 - 0.00042 19.5 0.3 0.016 14.4 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 CDI83166.1 - 0.0005 19.9 0.0 0.023 14.5 0.0 2.7 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 CDI83166.1 - 0.00053 19.4 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 CDI83166.1 - 0.00057 19.7 0.0 0.63 9.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 CDI83166.1 - 0.00083 18.8 0.1 0.37 10.2 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.1 CDI83166.1 - 0.00094 19.4 0.0 0.0077 16.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CDI83166.1 - 0.0018 17.4 0.1 0.0043 16.1 0.1 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.1 CDI83166.1 - 0.004 17.1 0.0 0.0089 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 CDI83166.1 - 0.011 15.4 0.1 0.063 12.9 0.0 2.3 2 0 0 2 2 2 0 NTPase DUF2075 PF09848.4 CDI83166.1 - 0.011 14.7 0.0 0.04 12.8 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.12 CDI83166.1 - 0.013 14.3 0.3 0.032 13.0 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.1 CDI83166.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain DnaB_C PF03796.10 CDI83166.1 - 0.015 14.1 0.1 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ResIII PF04851.10 CDI83166.1 - 0.016 15.0 0.1 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.11 CDI83166.1 - 0.025 13.8 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein PIF1 PF05970.9 CDI83166.1 - 0.026 13.4 0.0 1.5 7.7 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Sigma54_activ_2 PF14532.1 CDI83166.1 - 0.026 14.5 0.0 3.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.17 CDI83166.1 - 0.032 14.4 0.0 0.077 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.1 CDI83166.1 - 0.049 13.9 0.0 0.1 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain UPF0079 PF02367.12 CDI83166.1 - 0.055 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Arch_ATPase PF01637.13 CDI83166.1 - 0.058 13.0 0.0 0.73 9.4 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase NACHT PF05729.7 CDI83166.1 - 0.058 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Torsin PF06309.6 CDI83166.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Torsin GvpD PF07088.6 CDI83166.1 - 0.082 11.2 0.0 0.91 7.7 0.0 2.0 2 0 0 2 2 2 0 GvpD gas vesicle protein Rad17 PF03215.10 CDI83166.1 - 0.18 10.4 0.0 0.45 9.1 0.0 1.6 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Enterotoxin_b PF01376.13 CDI83168.1 - 0.026 14.4 0.3 18 5.2 0.0 3.1 3 0 0 3 3 3 0 Heat-labile enterotoxin beta chain DUF641 PF04859.7 CDI83169.1 - 0.7 9.6 13.0 0.11 12.2 5.0 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FUSC PF04632.7 CDI83169.1 - 1.4 7.2 8.9 1.6 7.0 6.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6 PF04111.7 CDI83169.1 - 1.7 7.6 17.7 2 7.3 12.3 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2968 PF11180.3 CDI83169.1 - 1.7 7.9 17.3 2.3 7.5 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) IncA PF04156.9 CDI83169.1 - 3 7.4 14.6 4.2 6.9 10.1 1.3 1 0 0 1 1 1 0 IncA protein DDHD PF02862.12 CDI83169.1 - 3.1 7.5 7.5 3.9 7.2 5.2 1.1 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.9 CDI83169.1 - 3.6 5.5 12.0 4.4 5.2 8.3 1.0 1 0 0 1 1 1 0 CDC45-like protein AAA_11 PF13086.1 CDI83169.1 - 3.7 7.0 7.2 4.9 6.6 5.0 1.3 1 0 0 1 1 1 0 AAA domain GBP_C PF02841.9 CDI83169.1 - 4.2 6.4 17.4 5.3 6.1 12.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Usp PF00582.21 CDI83169.1 - 4.3 7.5 6.8 6.1 7.0 4.7 1.2 1 0 0 1 1 1 0 Universal stress protein family V_ATPase_I PF01496.14 CDI83169.1 - 4.4 5.0 7.3 4.9 4.8 5.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase PF00069.20 CDI83170.1 - 2.3e-11 43.3 13.1 5.6e-10 38.8 0.0 4.1 1 1 4 5 5 5 1 Protein kinase domain APH PF01636.18 CDI83170.1 - 7e-06 25.9 22.0 1.3e-05 25.0 4.2 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 CDI83170.1 - 0.00041 19.4 9.8 0.00056 19.0 3.1 2.6 1 1 1 2 2 2 1 Protein tyrosine kinase Pex14_N PF04695.8 CDI83170.1 - 0.00043 20.3 23.1 0.044 13.8 5.1 2.1 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF912 PF06024.7 CDI83170.1 - 0.00052 20.0 2.7 0.45 10.5 0.1 2.2 2 0 0 2 2 2 2 Nucleopolyhedrovirus protein of unknown function (DUF912) FemAB PF02388.11 CDI83170.1 - 0.0065 15.1 4.7 0.0065 15.1 3.2 2.0 2 0 0 2 2 2 1 FemAB family Dynactin_p62 PF05502.8 CDI83170.1 - 0.023 13.4 26.3 0.25 10.0 6.1 2.3 1 1 0 2 2 2 0 Dynactin p62 family PAP1 PF08601.5 CDI83170.1 - 0.026 14.2 16.3 0.043 13.4 2.2 2.0 2 0 0 2 2 2 0 Transcription factor PAP1 OmpH PF03938.9 CDI83170.1 - 0.028 14.3 52.5 0.15 11.9 14.3 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4463 PF14703.1 CDI83170.1 - 0.032 14.7 3.6 4.2 7.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4463) Ctr PF04145.10 CDI83170.1 - 0.049 13.6 12.0 0.4 10.7 2.1 2.2 2 0 0 2 2 2 0 Ctr copper transporter family OHA PF14418.1 CDI83170.1 - 0.072 12.5 0.1 18 4.9 0.0 2.7 2 0 0 2 2 2 0 OST-HTH Associated domain DUF1800 PF08811.6 CDI83170.1 - 0.073 11.9 23.8 0.17 10.7 4.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1800) DUF1764 PF08576.5 CDI83170.1 - 0.078 13.7 17.7 0.95 10.2 3.1 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) RR_TM4-6 PF06459.7 CDI83170.1 - 0.15 11.9 16.0 1.1 9.1 2.7 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4366 PF14283.1 CDI83170.1 - 0.21 10.9 6.1 2.5 7.4 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) YrbL-PhoP_reg PF10707.4 CDI83170.1 - 0.29 10.4 0.0 0.29 10.4 0.0 3.0 2 1 1 3 3 3 0 PhoP regulatory network protein YrbL Tim54 PF11711.3 CDI83170.1 - 0.35 9.4 10.6 0.62 8.5 0.5 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF3726 PF12525.3 CDI83170.1 - 0.38 10.5 9.7 3.4 7.5 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3726) Dala_Dala_lig_N PF01820.16 CDI83170.1 - 0.5 10.6 7.4 4.6 7.5 0.6 2.2 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AUX_IAA PF02309.11 CDI83170.1 - 0.51 10.0 10.6 1.3 8.7 0.7 2.1 2 0 0 2 2 2 0 AUX/IAA family Herpes_UL25 PF01499.11 CDI83170.1 - 0.58 8.4 15.2 0.49 8.6 2.0 2.0 2 0 0 2 2 2 0 Herpesvirus UL25 family DUF972 PF06156.8 CDI83170.1 - 0.6 10.4 18.8 2.5 8.5 3.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF775 PF05603.7 CDI83170.1 - 0.69 9.3 22.6 0.61 9.5 3.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Ndc1_Nup PF09531.5 CDI83170.1 - 0.83 8.0 14.2 1.1 7.6 9.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Herpes_U44 PF04533.8 CDI83170.1 - 0.95 8.6 12.4 2.8 7.1 1.7 2.1 2 0 0 2 2 2 0 Herpes virus U44 protein PPP4R2 PF09184.6 CDI83170.1 - 1 8.8 16.1 2.3 7.7 2.7 2.1 2 0 0 2 2 2 0 PPP4R2 PEX11 PF05648.9 CDI83170.1 - 1.1 8.4 11.2 2.9 7.1 1.5 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Lin-8 PF03353.10 CDI83170.1 - 1.2 8.3 19.6 1.5 7.9 3.6 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF2052 PF09747.4 CDI83170.1 - 1.2 9.0 24.2 0.77 9.6 4.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Packaging_FI PF14000.1 CDI83170.1 - 1.3 9.2 6.3 10 6.3 0.3 2.1 2 0 0 2 2 2 0 DNA packaging protein FI DDHD PF02862.12 CDI83170.1 - 1.5 8.5 13.7 1.4 8.6 1.2 2.0 2 0 0 2 2 2 0 DDHD domain ABC2_membrane_3 PF12698.2 CDI83170.1 - 1.5 7.7 7.1 1.3 7.9 0.4 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF605 PF04652.11 CDI83170.1 - 2.2 7.6 29.1 1.5 8.1 6.6 2.0 2 0 0 2 2 2 0 Vta1 like TerB-C PF15615.1 CDI83170.1 - 2.3 8.4 10.5 6.2 7.0 1.1 2.1 2 0 0 2 2 2 0 TerB-C domain Cyclin PF08613.6 CDI83170.1 - 2.5 8.4 5.9 5 7.5 0.4 2.1 2 0 0 2 2 2 0 Cyclin DUF3752 PF12572.3 CDI83170.1 - 2.5 8.1 22.2 5.6 7.0 4.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3752) RED_N PF07808.8 CDI83170.1 - 2.9 7.0 28.9 0.98 8.5 6.3 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region F-protein PF00469.15 CDI83170.1 - 3 7.1 15.0 1.5 8.1 1.8 2.1 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Band_3_cyto PF07565.8 CDI83170.1 - 3.2 7.1 17.5 1 8.8 2.0 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain YppG PF14179.1 CDI83170.1 - 3.4 8.3 50.9 6.5 7.4 14.8 2.1 2 0 0 2 2 2 0 YppG-like protein SpoVR PF04293.8 CDI83170.1 - 3.9 5.7 17.7 1.1 7.5 3.1 2.1 2 0 0 2 2 2 0 SpoVR like protein DUF1266 PF06889.6 CDI83170.1 - 4.3 7.1 17.9 3.2 7.5 2.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) Peptidase_S15 PF02129.13 CDI83170.1 - 4.3 6.6 13.7 2 7.7 1.4 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF4557 PF15101.1 CDI83170.1 - 4.5 7.0 44.6 1.4 8.6 11.7 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4557) Neur_chan_memb PF02932.11 CDI83170.1 - 4.9 6.9 15.0 9.5 6.0 10.3 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4512 PF14975.1 CDI83170.1 - 5.1 7.9 8.1 18 6.2 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Maf1 PF09174.5 CDI83170.1 - 5.3 6.8 10.8 5.8 6.7 0.9 2.1 2 0 0 2 2 2 0 Maf1 regulator AIF_C PF14721.1 CDI83170.1 - 5.7 7.1 16.3 4.7 7.4 2.2 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SeqA PF03925.8 CDI83170.1 - 5.8 6.5 17.8 2.9 7.5 3.0 2.1 2 0 0 2 2 2 0 SeqA protein DUF2203 PF09969.4 CDI83170.1 - 6.7 6.9 18.5 2.8 8.1 1.9 2.8 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Spore_coat_CotO PF14153.1 CDI83170.1 - 7.6 5.9 28.9 0.95 8.8 5.4 2.1 2 0 0 2 2 2 0 Spore coat protein CotO Not3 PF04065.10 CDI83170.1 - 7.8 5.6 23.8 4.4 6.4 5.1 2.1 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component LLC1 PF14945.1 CDI83170.1 - 7.9 6.8 16.8 10 6.4 3.0 2.1 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein RNA_pol_Rpc4 PF05132.9 CDI83170.1 - 8.1 6.4 18.9 4.8 7.1 3.1 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 MDFI PF15316.1 CDI83170.1 - 8.3 6.3 7.4 7 6.6 0.2 2.1 2 0 0 2 2 2 0 MyoD family inhibitor Glyco_transf_15 PF01793.11 CDI83170.1 - 8.4 5.2 14.5 3.4 6.5 1.8 2.1 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase MCPVI PF02993.9 CDI83170.1 - 9.2 6.3 26.6 6.9 6.7 6.1 2.1 2 0 0 2 2 2 0 Minor capsid protein VI Afi1 PF07792.7 CDI83170.1 - 9.2 6.2 17.6 2.5 8.1 2.6 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1183 PF06682.7 CDI83170.1 - 9.8 5.6 12.7 15 5.0 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) DnaJ PF00226.26 CDI83174.1 - 6.3e-12 45.0 2.1 7.1e-12 44.8 0.0 2.3 2 1 0 2 2 2 1 DnaJ domain EF1G PF00647.14 CDI83174.1 - 0.087 12.5 0.2 0.17 11.5 0.0 1.6 1 1 0 1 1 1 0 Elongation factor 1 gamma, conserved domain AAA PF00004.24 CDI83175.1 - 2.3e-24 86.0 0.2 2.2e-22 79.6 0.1 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.13 CDI83175.1 - 2.1e-12 46.7 1.4 3.3e-12 46.0 0.2 2.0 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Vps4_C PF09336.5 CDI83175.1 - 1.9e-05 24.4 1.0 4.6e-05 23.2 0.2 2.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 CDI83175.1 - 0.00024 21.2 0.1 0.0015 18.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDI83175.1 - 0.022 14.1 0.4 0.57 9.5 0.3 2.6 1 1 0 1 1 1 0 AAA domain TPR_5 PF12688.2 CDI83175.1 - 0.031 14.3 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat ATP_bind_4 PF01902.12 CDI83176.1 - 4.9e-34 117.6 0.0 1.4e-33 116.1 0.0 1.7 1 1 0 1 1 1 1 ATP-binding region Ribosomal_L33 PF00471.15 CDI83178.1 - 2e-09 37.5 0.9 2.8e-09 37.0 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L33 DDE_2 PF02914.10 CDI83178.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Mu transposase SH3_2 PF07653.12 CDI83188.1 - 0.02 14.3 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain FTR PF01913.13 CDI83188.1 - 2.4 7.8 8.2 0.055 13.1 0.2 2.4 2 0 0 2 2 2 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase Utp14 PF04615.8 CDI83190.1 - 8.5 4.4 51.3 9.2 4.2 35.5 1.0 1 0 0 1 1 1 0 Utp14 protein M_domain PF12938.2 CDI83192.1 - 7.8 6.2 12.8 9.3 5.9 8.9 1.1 1 0 0 1 1 1 0 M domain of GW182 Rab5ip PF07019.7 CDI83193.1 - 8.5e-10 38.6 4.5 9e-05 22.5 0.1 2.0 1 1 1 2 2 2 2 Rab5-interacting protein (Rab5ip) DUF3457 PF11939.3 CDI83194.1 - 0.071 12.6 0.1 0.071 12.6 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3457) Herpes_UL87 PF03043.9 CDI83195.1 - 4.4 5.5 17.5 4.1 5.6 9.6 2.5 2 0 0 2 2 2 0 Herpesvirus UL87 family SR-25 PF10500.4 CDI83196.1 - 0.0018 17.7 8.8 0.0018 17.7 6.1 7.5 4 1 1 6 6 6 2 Nuclear RNA-splicing-associated protein IncA PF04156.9 CDI83196.1 - 6.6 6.2 70.2 0.27 10.8 14.9 5.8 5 0 0 5 5 5 0 IncA protein SNF PF00209.13 CDI83198.1 - 4.4e-21 74.9 6.8 4e-20 71.7 1.3 2.2 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family Med15 PF09606.5 CDI83199.1 - 0.75 7.9 35.8 1.2 7.2 24.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TSP_1 PF00090.14 CDI83201.1 - 1.6 8.9 27.8 1.1 9.4 0.3 4.9 4 0 0 4 4 4 0 Thrombospondin type 1 domain zf-DHHC PF01529.15 CDI83202.1 - 4.6e-38 130.3 7.2 4.6e-38 130.3 5.0 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4212 PF13937.1 CDI83202.1 - 1.1 9.3 5.6 11 6.1 2.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4212) TPR_2 PF07719.12 CDI83204.1 - 0.054 13.4 2.0 0.27 11.2 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat VTC PF09359.5 CDI83205.1 - 2.4e-75 253.1 0.0 6.4e-73 245.2 0.0 2.2 1 1 0 1 1 1 1 VTC domain DUF202 PF02656.10 CDI83205.1 - 7.5e-05 22.8 5.4 0.0011 19.1 3.7 2.7 1 1 0 1 1 1 1 Domain of unknown function (DUF202) OmpH PF03938.9 CDI83208.1 - 3.6 7.4 41.4 0.8 9.6 19.4 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Ligase_CoA PF00549.14 CDI83210.1 - 4e-19 68.7 1.9 4e-19 68.7 1.3 1.6 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_2 PF08442.5 CDI83210.1 - 1.9e-17 63.3 5.3 4.4e-10 39.2 1.6 2.9 1 1 1 2 2 2 2 ATP-grasp domain Succ_CoA_lig PF13607.1 CDI83210.1 - 0.0017 17.9 0.7 0.0033 17.0 0.5 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_5 PF13549.1 CDI83210.1 - 0.0085 15.3 1.3 0.0094 15.1 0.1 1.7 2 0 0 2 2 2 1 ATP-grasp domain CBM_14 PF01607.19 CDI83215.1 - 0.082 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Zip PF02535.17 CDI83215.1 - 0.37 9.7 12.4 0.99 8.3 8.3 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter Baculo_VP91_N PF08475.5 CDI83215.1 - 2 7.7 9.3 4 6.7 6.5 1.4 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal Neur_chan_memb PF02932.11 CDI83215.1 - 3.1 7.6 6.9 7.8 6.3 4.8 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tetraspannin PF00335.15 CDI83216.1 - 0.053 12.7 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF3068 PF11271.3 CDI83216.1 - 0.086 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3068) Med15 PF09606.5 CDI83216.1 - 1.2 7.2 19.2 0.16 10.1 0.2 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal RskA PF10099.4 CDI83216.1 - 2.2 8.0 7.9 0.21 11.2 1.9 2.0 3 0 0 3 3 3 0 Anti-sigma-K factor rskA Claudin_2 PF13903.1 CDI83216.1 - 3.5 7.2 5.1 0.44 10.2 0.1 1.9 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction FimP PF09766.4 CDI83216.1 - 4.4 6.2 11.9 0.23 10.4 0.1 2.2 2 0 0 2 2 2 0 Fms-interacting protein Gaa1 PF04114.9 CDI83218.1 - 0.054 12.1 2.2 1.4 7.5 0.1 3.0 3 0 0 3 3 3 0 Gaa1-like, GPI transamidase component AAA_11 PF13086.1 CDI83219.1 - 0.012 15.2 8.6 0.025 14.1 0.7 3.0 3 0 0 3 3 3 0 AAA domain FimP PF09766.4 CDI83219.1 - 0.018 14.1 0.0 0.018 14.1 0.0 3.4 3 1 0 3 3 3 0 Fms-interacting protein Cad PF03596.8 CDI83219.1 - 0.037 13.7 0.1 0.067 12.8 0.1 1.3 1 0 0 1 1 1 0 Cadmium resistance transporter FA_desaturase PF00487.19 CDI83219.1 - 0.82 9.0 6.6 5.3 6.4 0.3 2.6 2 2 1 3 3 3 0 Fatty acid desaturase Ycf1 PF05758.7 CDI83219.1 - 2 6.0 7.5 0.57 7.8 0.1 2.2 2 0 0 2 2 2 0 Ycf1 DUF4207 PF13904.1 CDI83219.1 - 4.4 6.6 42.3 0.12 11.6 2.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) DnaG_DnaB_bind PF08278.6 CDI83220.1 - 0.18 12.0 11.8 0.11 12.6 6.9 1.7 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding FadR_C PF07840.7 CDI83220.1 - 0.19 11.3 1.7 0.21 11.1 0.4 1.6 1 1 0 1 1 1 0 FadR C-terminal domain Ribosomal_60s PF00428.14 CDI83220.1 - 0.36 11.2 16.6 0.39 11.1 4.6 2.1 1 1 1 2 2 2 0 60s Acidic ribosomal protein RsbRD_N PF14361.1 CDI83220.1 - 2.5 8.6 10.3 0.41 11.1 0.4 2.3 2 1 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Nitroreductase PF00881.19 CDI83220.1 - 3.4 7.4 7.7 4.2 7.1 5.3 1.3 1 0 0 1 1 1 0 Nitroreductase family Fes1 PF08609.5 CDI83220.1 - 5 7.6 6.1 11 6.5 4.3 1.8 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 Ndc1_Nup PF09531.5 CDI83220.1 - 6.4 5.0 11.3 6.3 5.0 7.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_M9 PF01752.12 CDI83222.1 - 2.2 7.0 4.7 3.9 6.2 0.9 2.3 2 0 0 2 2 2 0 Collagenase PAT1 PF09770.4 CDI83223.1 - 0.32 9.1 19.5 0.34 9.0 13.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Activator_LAG-3 PF11498.3 CDI83226.1 - 0.02 13.6 20.6 0.021 13.5 14.2 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CNH PF00780.17 CDI83226.1 - 0.031 13.7 2.2 0.037 13.4 1.5 1.1 1 0 0 1 1 1 0 CNH domain Med15 PF09606.5 CDI83226.1 - 0.15 10.2 36.0 0.24 9.5 24.9 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Nucleoporin_N PF08801.6 CDI83226.1 - 0.17 10.6 0.9 0.2 10.3 0.6 1.1 1 0 0 1 1 1 0 Nup133 N terminal like Rtf2 PF04641.7 CDI83226.1 - 0.24 10.5 6.2 0.32 10.1 4.3 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Serinc PF03348.10 CDI83226.1 - 0.92 8.1 4.7 1 7.9 3.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) TMEM154 PF15102.1 CDI83226.1 - 1.3 8.7 8.3 1.2 8.8 5.1 1.7 1 1 0 1 1 1 0 TMEM154 protein family IPK PF03770.11 CDI83226.1 - 1.4 8.4 5.6 1.9 8.0 3.9 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase DUF1314 PF07013.6 CDI83226.1 - 1.9 7.8 4.3 3.3 7.0 2.6 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1314) PAT1 PF09770.4 CDI83226.1 - 3.4 5.8 24.3 3.4 5.7 16.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.1 CDI83226.1 - 5.8 7.1 8.3 7.4 6.8 5.8 1.1 1 0 0 1 1 1 0 AAA domain SSP160 PF06933.6 CDI83228.1 - 0.0019 16.3 14.0 0.0019 16.3 9.7 1.8 2 0 0 2 2 2 1 Special lobe-specific silk protein SSP160 Med15 PF09606.5 CDI83228.1 - 0.0024 16.1 11.4 0.002 16.4 7.9 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal SPX PF03105.14 CDI83228.1 - 0.003 17.4 3.8 0.0038 17.0 2.6 1.1 1 0 0 1 1 1 1 SPX domain FCP1_C PF09309.5 CDI83228.1 - 0.02 14.2 5.3 0.027 13.8 3.6 1.2 1 0 0 1 1 1 0 FCP1, C-terminal DUF2489 PF10675.4 CDI83228.1 - 0.038 13.6 7.0 0.063 12.9 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) FRQ PF09421.5 CDI83228.1 - 0.1 10.3 11.6 0.12 10.1 8.1 1.0 1 0 0 1 1 1 0 Frequency clock protein Tetraspannin PF00335.15 CDI83228.1 - 0.11 11.7 5.8 0.12 11.5 4.0 1.1 1 0 0 1 1 1 0 Tetraspanin family Plasmodium_Vir PF05795.6 CDI83228.1 - 0.13 11.4 3.3 0.15 11.2 2.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Macoilin PF09726.4 CDI83228.1 - 0.14 10.4 11.7 0.18 10.0 8.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Cwf_Cwc_15 PF04889.7 CDI83228.1 - 0.14 11.8 6.5 0.18 11.4 4.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sporozoite_P67 PF05642.6 CDI83228.1 - 0.18 9.6 7.9 0.21 9.3 5.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF912 PF06024.7 CDI83228.1 - 0.26 11.3 3.3 2.6 8.1 0.3 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SAPS PF04499.10 CDI83228.1 - 0.61 8.6 5.8 0.7 8.4 4.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2217 PF10265.4 CDI83228.1 - 0.69 8.6 12.6 0.79 8.4 8.8 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Presenilin PF01080.12 CDI83228.1 - 0.76 8.5 8.1 0.9 8.2 5.6 1.1 1 0 0 1 1 1 0 Presenilin DNA_pol_viral_N PF00242.12 CDI83228.1 - 0.91 8.4 14.2 1 8.3 9.8 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Lin-8 PF03353.10 CDI83228.1 - 0.91 8.7 7.1 1 8.5 4.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.11 CDI83228.1 - 0.96 9.2 4.3 1.1 9.0 3.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.8 CDI83228.1 - 1 7.8 8.9 1.3 7.4 6.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S64 PF08192.6 CDI83228.1 - 1.3 7.2 8.5 1.3 7.2 5.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4512 PF14975.1 CDI83228.1 - 4.8 8.0 6.0 12 6.8 4.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) Ribosomal_60s PF00428.14 CDI83228.1 - 8.1 6.9 16.8 1.2 9.5 0.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein PAT1 PF09770.4 CDI83230.1 - 0.24 9.6 45.7 0.39 8.8 31.7 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.9 CDI83230.1 - 0.76 7.7 10.9 1.1 7.1 7.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 CDI83230.1 - 1.2 6.7 12.1 1.5 6.4 8.4 1.1 1 0 0 1 1 1 0 Ycf1 Med15 PF09606.5 CDI83230.1 - 2.5 6.2 63.9 0.017 13.3 38.1 1.7 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Band_3_cyto PF07565.8 CDI83230.1 - 9 5.7 12.1 50 3.2 8.7 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain NifU PF01106.12 CDI83231.1 - 1e-20 73.2 0.1 1.9e-20 72.3 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain Med15 PF09606.5 CDI83231.1 - 0.074 11.2 48.8 0.13 10.4 33.8 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal BAF1_ABF1 PF04684.8 CDI83231.1 - 0.41 9.4 49.6 0.028 13.2 9.9 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PAT1 PF09770.4 CDI83231.1 - 0.69 8.0 41.6 0.93 7.6 28.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Utp14 PF04615.8 CDI83231.1 - 0.87 7.6 29.8 1.1 7.3 20.7 1.1 1 0 0 1 1 1 0 Utp14 protein DUF3446 PF11928.3 CDI83231.1 - 3.2 8.0 16.0 0.42 10.8 7.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) FimP PF09766.4 CDI83231.1 - 6.9 5.6 30.0 1.3 8.0 8.6 2.4 2 0 0 2 2 2 0 Fms-interacting protein MSP1_C PF07462.6 CDI83231.1 - 9.7 4.4 22.7 1.6 7.0 8.6 2.1 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus DUF2125 PF09898.4 CDI83233.1 - 0.29 10.3 16.1 0.35 10.1 11.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2125) DUF1510 PF07423.6 CDI83233.1 - 0.93 8.8 8.6 0.96 8.7 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3987 PF13148.1 CDI83233.1 - 0.94 7.9 15.2 1 7.8 10.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) CT47 PF15623.1 CDI83233.1 - 1.4 8.6 33.8 1.5 8.4 23.4 1.0 1 0 0 1 1 1 0 Cancer/testis gene family 47 Spore_coat_CotO PF14153.1 CDI83233.1 - 1.8 7.9 9.2 2.1 7.7 6.4 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Glyco_transf_20 PF00982.16 CDI83234.1 - 7.1e-24 84.1 0.0 7.1e-24 84.1 0.0 6.5 5 2 3 8 8 8 1 Glycosyltransferase family 20 Med26 PF08711.6 CDI83235.1 - 9.4e-10 37.8 0.1 1.6e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ndc1_Nup PF09531.5 CDI83235.1 - 1.7 6.9 12.7 2.7 6.3 8.8 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup N6_N4_Mtase PF01555.13 CDI83236.1 - 0.011 15.2 0.2 0.084 12.3 0.2 2.1 2 0 0 2 2 2 0 DNA methylase HSP70 PF00012.15 CDI83237.1 - 2.8e-263 874.3 10.6 3.2e-263 874.1 7.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDI83237.1 - 2.2e-19 69.2 1.9 1.9e-18 66.1 0.6 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 CDI83237.1 - 0.0095 15.7 3.3 2.2 8.1 0.1 3.8 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.11 CDI83237.1 - 0.01 15.5 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 CDI83237.1 - 0.071 12.2 0.2 0.071 12.2 0.1 2.5 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase TFIIIC_delta PF12657.2 CDI83239.1 - 0.061 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term S1 PF00575.18 CDI83240.1 - 0.003 17.6 0.2 0.12 12.4 0.2 2.9 3 0 0 3 3 3 1 S1 RNA binding domain S1 PF00575.18 CDI83241.1 - 1.3e-05 25.1 0.0 1.2 9.3 0.0 6.3 6 1 0 6 6 6 2 S1 RNA binding domain Pox_A11 PF05061.8 CDI83242.1 - 0.63 9.0 5.4 5.2 6.0 1.8 2.5 2 0 0 2 2 2 0 Poxvirus A11 Protein DUF4475 PF14753.1 CDI83243.1 - 0.00012 21.6 2.2 0.00017 21.1 1.3 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4475) PAT1 PF09770.4 CDI83243.1 - 0.0004 18.7 24.6 0.0004 18.7 17.0 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 SAGA-Tad1 PF12767.2 CDI83243.1 - 0.0029 17.3 9.1 0.0031 17.2 6.3 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit FLO_LFY PF01698.11 CDI83243.1 - 0.0062 15.4 2.1 0.0067 15.3 1.5 1.1 1 0 0 1 1 1 1 Floricaula / Leafy protein Hid1 PF12722.2 CDI83243.1 - 0.011 13.4 5.6 0.012 13.3 3.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.7 CDI83243.1 - 0.031 14.1 3.1 0.037 13.9 2.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CRT10 PF08728.5 CDI83243.1 - 0.092 10.7 3.6 0.1 10.5 2.5 1.0 1 0 0 1 1 1 0 CRT10 DUF605 PF04652.11 CDI83243.1 - 0.097 12.0 19.3 0.11 11.8 13.4 1.1 1 0 0 1 1 1 0 Vta1 like Herpes_env PF01673.13 CDI83243.1 - 0.1 11.0 6.7 0.13 10.7 4.7 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein SID-1_RNA_chan PF13965.1 CDI83243.1 - 0.14 10.2 3.3 0.18 9.9 2.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.10 CDI83243.1 - 0.27 9.8 3.6 0.38 9.4 2.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.11 CDI83243.1 - 0.33 10.8 6.4 0.43 10.4 4.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4175 PF13779.1 CDI83243.1 - 0.46 8.1 36.1 0.64 7.6 25.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Glyco_hydro_2_N PF02837.13 CDI83243.1 - 0.46 10.0 7.5 0.66 9.5 5.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain FHIPEP PF00771.15 CDI83243.1 - 0.73 8.0 7.1 0.82 7.9 4.9 1.1 1 0 0 1 1 1 0 FHIPEP family DUF1863 PF08937.6 CDI83243.1 - 0.75 9.8 4.1 1.1 9.3 2.9 1.2 1 0 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Cellulose_synt PF03552.9 CDI83243.1 - 1.1 7.4 3.9 1.4 7.1 2.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Baculo_PP31 PF05311.6 CDI83243.1 - 1.3 8.2 11.7 1.7 7.8 8.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2215 PF10225.4 CDI83243.1 - 1.3 8.3 6.5 1.8 7.9 4.5 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) DUF106 PF01956.11 CDI83243.1 - 1.4 8.4 8.5 1.9 7.9 5.9 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 Band_3_cyto PF07565.8 CDI83243.1 - 2.5 7.5 10.3 3.6 7.0 7.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Paramyxo_ncap PF00973.14 CDI83243.1 - 2.8 6.5 8.0 3.5 6.1 5.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Herpes_glycop PF01528.11 CDI83243.1 - 6.4 5.3 7.3 10 4.7 5.1 1.4 1 1 0 1 1 1 0 Herpesvirus glycoprotein M Nuc_deoxyrib_tr PF05014.10 CDI83243.1 - 7.9 6.3 6.7 15 5.4 4.3 1.7 1 1 1 2 2 2 0 Nucleoside 2-deoxyribosyltransferase AAA_23 PF13476.1 CDI83243.1 - 8.3 6.6 14.9 11 6.3 10.4 1.1 1 0 0 1 1 1 0 AAA domain MKT1_C PF12246.3 CDI83244.1 - 1.5e-20 73.2 0.5 1.8e-19 69.7 0.0 2.6 2 1 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 CDI83244.1 - 1.4e-11 44.3 0.0 3.7e-11 42.9 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 CDI83244.1 - 4.2e-09 36.5 0.0 1.5e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain Med15 PF09606.5 CDI83244.1 - 7.6e-08 31.0 18.4 7.6e-08 31.0 12.8 3.2 3 0 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_23 PF13476.1 CDI83244.1 - 3.1 8.0 13.3 36 4.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DDHD PF02862.12 CDI83244.1 - 7.1 6.3 16.7 2 8.1 4.0 3.3 3 0 0 3 3 3 0 DDHD domain TFIIA PF03153.8 CDI83244.1 - 8.4 6.1 33.5 0.032 14.1 11.2 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit PKD_channel PF08016.7 CDI83245.1 - 1.2e-11 43.7 34.1 1e-07 30.7 8.3 4.0 4 0 0 4 4 4 2 Polycystin cation channel RAP1 PF07218.6 CDI83245.1 - 0.39 8.7 0.1 0.62 8.0 0.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Cullin PF00888.17 CDI83246.1 - 7.3e-113 378.1 4.4 1.9e-56 191.8 0.1 2.1 2 0 0 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.4 CDI83246.1 - 1.2e-23 82.6 0.4 3.8e-23 81.0 0.3 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF3658 PF12395.3 CDI83246.1 - 0.005 16.3 0.2 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function DUF445 PF04286.7 CDI83246.1 - 0.91 8.9 5.0 0.99 8.8 1.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF445) DDDD PF10161.4 CDI83249.1 - 0.14 11.7 0.1 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 Putative mitochondrial precursor protein RseC_MucC PF04246.7 CDI83249.1 - 5.9 6.4 13.3 1.1 8.8 2.7 3.0 2 2 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Mmp37 PF09139.6 CDI83250.1 - 2.9e-22 79.1 0.0 2.9e-10 39.6 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial matrix Mmp37 ACBP PF00887.14 CDI83251.1 - 1.5e-19 69.3 0.2 6.3e-19 67.4 0.1 2.1 1 0 0 1 1 1 1 Acyl CoA binding protein Dehydrin PF00257.14 CDI83251.1 - 0.015 15.6 4.8 0.015 15.6 3.3 3.5 3 1 0 3 3 3 0 Dehydrin PAT1 PF09770.4 CDI83251.1 - 0.017 13.4 88.9 0.095 10.9 18.0 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RteC PF09357.5 CDI83251.1 - 0.061 13.1 0.0 0.061 13.1 0.0 2.8 3 0 0 3 3 3 0 RteC protein Neur_chan_memb PF02932.11 CDI83251.1 - 1.2 8.9 26.9 3.2 7.5 5.1 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.8 CDI83251.1 - 4.4 7.0 66.8 1.1 9.1 14.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA PF00004.24 CDI83252.1 - 2.5e-42 144.1 0.0 2.7e-36 124.6 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 CDI83252.1 - 7.3e-10 38.7 0.0 1.6e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal IstB_IS21 PF01695.12 CDI83252.1 - 3.2e-05 23.4 0.1 0.00022 20.6 0.0 2.3 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_16 PF13191.1 CDI83252.1 - 0.0008 19.4 13.8 0.0033 17.4 0.2 4.3 4 1 0 4 4 4 2 AAA ATPase domain AAA_17 PF13207.1 CDI83252.1 - 0.0037 18.0 0.0 0.18 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDI83252.1 - 0.013 15.3 0.0 0.013 15.3 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_22 PF13401.1 CDI83252.1 - 0.019 15.0 0.1 2.2 8.4 0.1 3.4 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CDI83252.1 - 0.02 14.8 0.0 0.34 10.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 CDI83252.1 - 0.023 13.8 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 CDI83252.1 - 0.027 14.6 0.0 8 6.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.1 CDI83252.1 - 0.029 13.7 0.5 0.48 9.8 0.1 2.8 2 1 1 3 3 3 0 AAA domain AAA_5 PF07728.9 CDI83252.1 - 0.063 13.0 2.1 0.38 10.4 0.1 3.3 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CDI83252.1 - 0.2 10.6 0.1 0.67 8.9 0.1 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus PhoH PF02562.11 CDI83252.1 - 0.39 9.8 0.0 1.5 8.0 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Rad17 PF03215.10 CDI83252.1 - 0.52 8.9 0.5 21 3.6 0.0 2.5 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein PTP_N PF12453.3 CDI83253.1 - 0.058 13.0 1.4 0.87 9.2 0.1 3.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase N terminal Arm PF00514.18 CDI83254.1 - 6e-06 25.8 17.0 0.19 11.5 0.0 8.8 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat ThiF PF00899.16 CDI83255.1 - 4.8e-35 120.3 0.0 3e-34 117.7 0.0 2.0 1 1 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.1 CDI83255.1 - 0.022 14.9 0.4 0.14 12.4 0.3 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding Saccharop_dh PF03435.13 CDI83255.1 - 0.038 12.9 0.1 3.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase MoeZ_MoeB PF05237.8 CDI83255.1 - 0.11 12.1 1.3 0.18 11.3 0.1 2.0 2 0 0 2 2 2 0 MoeZ/MoeB domain Cpn10 PF00166.16 CDI83256.1 - 6.4e-15 54.8 0.0 7.7e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Herpes_gE PF02480.11 CDI83256.1 - 0.14 10.3 0.0 0.17 10.1 0.0 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E RPAP2_Rtr1 PF04181.8 CDI83257.1 - 1e-07 31.9 3.7 1.6e-07 31.3 1.1 2.5 1 1 1 2 2 2 1 Rtr1/RPAP2 family Trichoplein PF13868.1 CDI83258.1 - 1.4e-23 82.8 98.0 1.4e-23 82.8 68.0 2.5 1 1 1 2 2 2 1 Tumour suppressor, Mitostatin Ank_2 PF12796.2 CDI83260.1 - 6.2e-56 186.7 0.1 3e-19 69.1 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 CDI83260.1 - 3.4e-38 127.5 3.8 2.8e-07 30.0 0.0 8.2 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.1 CDI83260.1 - 1.4e-31 108.2 0.5 1.2e-12 48.0 0.0 5.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDI83260.1 - 5.1e-31 103.6 0.4 0.00024 21.0 0.0 7.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 CDI83260.1 - 5.4e-29 99.5 0.3 3.1e-07 30.4 0.0 5.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Nrap PF03813.9 CDI83262.1 - 2.8e-76 256.9 0.0 5.3e-21 73.9 0.0 6.3 4 1 1 6 6 6 6 Nrap protein RNase_H2-Ydr279 PF09468.5 CDI83263.1 - 6.2e-17 61.7 0.0 1.5e-16 60.4 0.0 1.5 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) NIF PF03031.13 CDI83264.1 - 4.1e-17 62.3 0.0 5.7e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Med15 PF09606.5 CDI83264.1 - 0.04 12.1 9.8 0.063 11.4 6.8 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal ZZ PF00569.12 CDI83267.1 - 8.8e-11 41.1 8.4 1.7e-10 40.2 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 CDI83267.1 - 1.3e-09 37.9 1.2 4.7e-09 36.1 0.0 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDI83267.1 - 2.1e-06 27.7 0.3 1.5e-05 24.9 0.0 2.6 3 0 0 3 3 3 1 Myb-like DNA-binding domain DUF3449 PF11931.3 CDI83267.1 - 0.02 14.4 0.6 0.045 13.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) DUF3043 PF11241.3 CDI83267.1 - 0.75 9.3 3.2 1.9 8.0 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) C1_3 PF07649.7 CDI83267.1 - 1.6 8.8 9.1 2.8 8.0 6.3 1.4 1 0 0 1 1 1 0 C1-like domain Med15 PF09606.5 CDI83271.1 - 0.00078 17.7 8.5 0.00078 17.7 5.9 10.9 7 3 2 10 10 10 4 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3899 PF13038.1 CDI83271.1 - 0.82 9.8 7.4 1e+02 3.1 0.0 5.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3899) DUF1195 PF06708.6 CDI83272.1 - 8 5.8 10.6 0.46 9.8 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1195) S-AdoMet_synt_C PF02773.11 CDI83273.1 - 2.4e-66 221.7 0.3 5.2e-66 220.5 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 CDI83273.1 - 1.4e-48 163.8 0.0 2.5e-48 162.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 CDI83273.1 - 9.2e-43 144.5 0.2 1.7e-42 143.6 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain DUF2312 PF10073.4 CDI83273.1 - 0.14 11.5 0.3 0.29 10.5 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) FAD_binding_4 PF01565.18 CDI83274.1 - 1.6e-34 118.3 0.1 2.6e-34 117.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF3626 PF12294.3 CDI83275.1 - 4.4e-05 22.6 0.0 0.00016 20.7 0.0 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3626) SET PF00856.23 CDI83276.1 - 0.019 15.2 0.0 0.097 12.9 0.0 2.2 2 0 0 2 2 2 0 SET domain TPR_16 PF13432.1 CDI83276.1 - 1.9 9.2 9.0 0.23 12.2 2.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PDEase_I PF00233.14 CDI83277.1 - 3.3e-41 141.5 0.1 6.2e-41 140.7 0.1 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.17 CDI83277.1 - 0.15 12.0 0.1 0.47 10.4 0.0 1.8 1 0 0 1 1 1 0 HD domain Med15 PF09606.5 CDI83277.1 - 0.58 8.2 8.4 0.97 7.5 5.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIF_alpha PF05793.7 CDI83278.1 - 0.026 12.8 10.6 0.035 12.4 6.3 1.7 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Med3 PF11593.3 CDI83278.1 - 6.8 5.8 23.8 10 5.2 16.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Clat_adaptor_s PF01217.15 CDI83279.1 - 2.7e-17 62.8 1.7 3.1e-17 62.6 1.1 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Abhydrolase_3 PF07859.8 CDI83282.1 - 2.2e-26 92.7 0.0 2.2e-26 92.7 0.0 4.1 3 2 0 3 3 3 1 alpha/beta hydrolase fold DUF2424 PF10340.4 CDI83282.1 - 1.1e-14 53.8 0.0 1.1e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2424) DUF3675 PF12428.3 CDI83282.1 - 2 8.6 4.9 17 5.7 3.4 2.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) Med15 PF09606.5 CDI83283.1 - 0.00052 18.3 30.3 0.00052 18.3 21.0 6.5 4 1 1 6 6 6 2 ARC105 or Med15 subunit of Mediator complex non-fungal MRP-S31 PF15433.1 CDI83284.1 - 0.00017 21.0 7.9 0.00021 20.7 5.5 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 GOLD_2 PF13897.1 CDI83284.1 - 0.023 14.9 1.0 0.023 14.9 0.7 2.5 1 1 2 3 3 3 0 Golgi-dynamics membrane-trafficking Phosducin PF02114.11 CDI83284.1 - 0.041 12.5 4.3 0.013 14.1 1.1 1.7 2 0 0 2 2 2 0 Phosducin TetR_N PF00440.18 CDI83284.1 - 0.042 13.4 0.0 0.089 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family SPX PF03105.14 CDI83284.1 - 0.77 9.4 9.1 0.98 9.1 6.3 1.2 1 0 0 1 1 1 0 SPX domain Staphylokinase PF02821.11 CDI83284.1 - 1.3 8.8 8.4 0.32 10.8 3.6 1.6 2 0 0 2 2 2 0 Staphylokinase/Streptokinase family DDHD PF02862.12 CDI83284.1 - 2 8.1 5.7 3.1 7.5 3.9 1.4 1 1 0 1 1 1 0 DDHD domain OB_NTP_bind PF07717.11 CDI83285.1 - 1.3e-26 92.6 0.0 3.9e-26 91.1 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CDI83285.1 - 5.9e-23 80.8 2.9 1.4e-22 79.6 0.0 3.1 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CDI83285.1 - 1.6e-11 43.8 0.0 3.8e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDI83285.1 - 7.8e-06 25.4 0.1 2e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 CDI83285.1 - 0.00065 18.6 0.0 0.0023 16.9 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.1 CDI83285.1 - 0.0011 19.0 0.3 0.0011 19.0 0.2 2.6 2 2 1 3 3 3 1 AAA domain AAA_14 PF13173.1 CDI83285.1 - 0.068 13.0 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Peptidase_S41 PF03572.13 CDI83285.1 - 0.13 11.6 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase family S41 Miro PF08477.8 CDI83285.1 - 0.13 12.7 0.2 0.76 10.2 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein AAA_23 PF13476.1 CDI83285.1 - 0.27 11.5 0.0 0.27 11.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain TPR_19 PF14559.1 CDI83286.1 - 2.5e-07 30.9 13.6 2.5e-06 27.7 0.0 4.0 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 CDI83286.1 - 3.4e-05 23.3 8.5 0.0052 16.4 0.0 3.8 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 CDI83286.1 - 0.0011 18.4 0.1 20 4.9 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 CDI83286.1 - 0.0021 18.5 19.7 0.0044 17.5 0.0 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI83286.1 - 0.014 15.2 10.2 1.2 9.2 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDI83286.1 - 0.12 12.2 7.9 1.7 8.6 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Syntaxin-6_N PF09177.6 CDI83286.1 - 0.43 11.0 0.1 0.43 11.0 0.0 3.5 3 2 0 3 3 3 0 Syntaxin 6, N-terminal TPR_16 PF13432.1 CDI83286.1 - 0.59 10.8 0.0 0.59 10.8 0.0 4.4 3 3 2 5 5 5 0 Tetratricopeptide repeat DUF3808 PF10300.4 CDI83286.1 - 1.9 6.9 9.6 0.4 9.1 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3808) DDHD PF02862.12 CDI83288.1 - 8.7 6.0 19.3 3.2 7.4 1.4 2.4 2 0 0 2 2 2 0 DDHD domain Ribosomal_60s PF00428.14 CDI83291.1 - 0.93 9.9 6.7 1.5 9.3 4.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF1218 PF06749.7 CDI83292.1 - 0.0059 17.0 6.0 0.029 14.8 2.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1218) Claudin_2 PF13903.1 CDI83292.1 - 0.024 14.3 4.6 0.23 11.1 0.2 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction RRM_1 PF00076.17 CDI83293.1 - 1.3e-16 59.9 0.0 6.2e-08 32.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI83293.1 - 5.8e-09 35.7 0.0 0.0023 17.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI83293.1 - 0.0013 18.5 0.0 0.042 13.6 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.8 CDI83293.1 - 2.4 7.9 19.9 0.11 12.3 8.8 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF3995 PF13160.1 CDI83294.1 - 0.25 11.3 5.6 0.054 13.5 1.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3995) DUF4228 PF14009.1 CDI83294.1 - 7 6.7 15.0 0.22 11.6 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4228) ubiquitin PF00240.18 CDI83295.1 - 2.7e-21 74.7 0.1 2.7e-21 74.7 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin family UBA PF00627.26 CDI83295.1 - 2.7e-07 30.2 0.1 7e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.3 CDI83295.1 - 3.4e-07 29.8 0.0 3.4e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 CDI83295.1 - 0.00012 21.9 1.0 0.00012 21.9 0.7 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CDI83295.1 - 0.001 19.2 0.8 0.0021 18.2 0.3 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain CUE PF02845.11 CDI83295.1 - 0.0026 17.2 0.0 0.0073 15.7 0.0 1.8 1 0 0 1 1 1 1 CUE domain Ubiquitin_2 PF14560.1 CDI83295.1 - 0.0041 17.3 0.0 0.0088 16.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain Peptidase_M3 PF01432.15 CDI83296.1 - 3.1e-11 42.9 0.0 1.5e-09 37.4 0.0 2.9 1 1 0 1 1 1 1 Peptidase family M3 MFS_2 PF13347.1 CDI83297.1 - 0.098 11.0 0.9 0.12 10.7 0.7 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein Kinase-like PF14531.1 CDI83299.1 - 2.6e-09 36.4 0.0 8.2e-09 34.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase PF00069.20 CDI83299.1 - 0.043 12.9 0.0 0.067 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Kinase-like PF14531.1 CDI83301.1 - 1.1e-05 24.5 0.0 2.5e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.20 CDI83301.1 - 0.00037 19.7 0.0 0.00058 19.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 CDI83302.1 - 7.7e-19 67.8 0.0 1.7e-14 53.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.1 CDI83302.1 - 1.6e-07 30.5 0.0 4.3e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI83302.1 - 7.2e-07 28.5 0.0 3.5e-06 26.2 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Solute_trans_a PF03619.11 CDI83303.1 - 1.4e-12 47.5 2.3 2.2e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 Organic solute transporter Ostalpha Pro_isomerase PF00160.16 CDI83305.1 - 1.3e-19 70.9 0.0 1.7e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Caldesmon PF02029.10 CDI83307.1 - 0.0009 17.7 9.2 0.0009 17.7 6.4 1.1 1 0 0 1 1 1 1 Caldesmon Ycf1 PF05758.7 CDI83307.1 - 0.023 12.4 2.9 0.022 12.5 2.0 1.2 1 0 0 1 1 1 0 Ycf1 DUF1764 PF08576.5 CDI83307.1 - 0.034 14.9 12.1 2.4 8.9 10.3 2.5 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF3373 PF11853.3 CDI83307.1 - 0.034 12.6 1.6 0.043 12.3 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) SAPS PF04499.10 CDI83307.1 - 0.072 11.7 4.8 0.082 11.5 3.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SprA-related PF12118.3 CDI83307.1 - 0.13 11.5 33.4 0.23 10.7 23.1 1.3 1 0 0 1 1 1 0 SprA-related family Raftlin PF15250.1 CDI83307.1 - 0.18 10.3 9.2 0.23 9.9 6.4 1.2 1 0 0 1 1 1 0 Raftlin Med15 PF09606.5 CDI83307.1 - 0.31 9.1 26.7 0.46 8.6 18.5 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RR_TM4-6 PF06459.7 CDI83307.1 - 0.49 10.2 19.6 0.93 9.3 13.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FLO_LFY PF01698.11 CDI83307.1 - 0.85 8.4 13.2 3.6 6.3 9.7 1.6 2 0 0 2 2 2 0 Floricaula / Leafy protein FimP PF09766.4 CDI83307.1 - 0.89 8.5 18.6 1.4 7.8 12.9 1.2 1 0 0 1 1 1 0 Fms-interacting protein CT47 PF15623.1 CDI83307.1 - 1.5 8.4 36.6 3.1 7.4 25.4 1.4 1 0 0 1 1 1 0 Cancer/testis gene family 47 FNIP_N PF14636.1 CDI83307.1 - 2.1 8.8 10.9 5.9 7.3 7.6 1.7 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus PMSI1 PF15322.1 CDI83307.1 - 2.4 7.1 14.0 4.6 6.2 9.7 1.5 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Peptidase_S15 PF02129.13 CDI83307.1 - 2.4 7.4 8.6 3.5 6.9 6.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) TFIIA PF03153.8 CDI83307.1 - 2.4 7.9 25.8 0.34 10.7 15.3 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF844 PF05815.6 CDI83307.1 - 2.5 6.8 10.8 8.8 5.0 0.0 2.3 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF844) 5_nucleotid PF05761.9 CDI83307.1 - 5.3 5.4 7.2 4.1 5.8 3.4 1.8 2 0 0 2 2 2 0 5' nucleotidase family Baculo_PP31 PF05311.6 CDI83307.1 - 5.4 6.1 12.7 8.3 5.5 8.8 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Serinc PF03348.10 CDI83307.1 - 7.4 5.1 7.5 10 4.7 5.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Sec62 PF03839.11 CDI83307.1 - 8.1 5.7 7.5 16 4.8 5.2 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 Suf PF05843.9 CDI83307.1 - 9.5 5.8 14.1 15 5.2 9.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MIF4G PF02854.14 CDI83308.1 - 6.9e-34 117.0 0.9 6.9e-34 117.0 0.6 2.1 2 0 0 2 2 2 1 MIF4G domain Peptidase_C48 PF02902.14 CDI83309.1 - 1.2e-15 57.6 10.4 8.3e-11 41.9 1.3 3.5 3 1 0 3 3 3 2 Ulp1 protease family, C-terminal catalytic domain IDO PF01231.13 CDI83309.1 - 0.0015 17.0 1.2 0.0015 17.0 0.9 2.0 2 0 0 2 2 2 1 Indoleamine 2,3-dioxygenase DUF3517 PF12030.3 CDI83309.1 - 0.076 11.5 0.3 0.15 10.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) Pkinase PF00069.20 CDI83310.1 - 8.3e-49 166.0 0.0 1.9e-48 164.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83310.1 - 5.4e-19 68.2 0.0 9.2e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NUDIX_2 PF13869.1 CDI83311.1 - 6.8e-57 191.8 0.0 8.7e-57 191.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase Diphthamide_syn PF01866.12 CDI83312.1 - 0.046 12.9 0.0 0.062 12.5 0.0 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein WD40 PF00400.27 CDI83313.1 - 0.00026 20.7 10.3 5 7.1 0.1 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat Kelch_4 PF13418.1 CDI83314.1 - 9.5e-17 60.5 6.5 1.1e-07 31.4 0.1 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI83314.1 - 6.4e-11 41.9 3.1 0.00014 21.6 0.1 3.5 4 1 1 5 5 5 2 Kelch motif Kelch_6 PF13964.1 CDI83314.1 - 6.8e-10 38.6 4.1 0.00043 20.3 0.0 4.2 2 1 2 4 4 4 2 Kelch motif Kelch_2 PF07646.10 CDI83314.1 - 1.2e-07 31.1 4.1 0.002 17.7 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 CDI83314.1 - 2e-07 30.4 4.3 1.7e-05 24.2 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.1 CDI83314.1 - 2e-06 27.8 9.4 2 8.6 0.0 5.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Sulfate_tra_GLY PF13792.1 CDI83314.1 - 0.053 13.1 0.9 0.11 12.2 0.6 1.5 1 0 0 1 1 1 0 Sulfate transporter N-terminal domain with GLY motif Peptidase_M22 PF00814.20 CDI83315.1 - 2.8e-72 243.4 0.2 1e-53 182.5 0.1 2.2 1 1 1 2 2 2 2 Glycoprotease family TraB PF01963.12 CDI83317.1 - 0.74 9.2 3.1 9.2 5.6 0.1 2.8 3 0 0 3 3 3 0 TraB family Laminin_G_3 PF13385.1 CDI83319.1 - 3.1e-16 59.9 0.0 2.4e-08 34.3 0.0 3.9 4 0 0 4 4 4 3 Concanavalin A-like lectin/glucanases superfamily FixQ PF05545.6 CDI83319.1 - 0.04 13.5 1.6 0.7 9.5 0.1 2.6 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ CLTH PF10607.4 CDI83322.1 - 3.7e-10 39.6 0.0 1.1e-09 38.0 0.0 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain DUF2192 PF09958.4 CDI83322.1 - 0.092 11.9 0.2 0.17 11.1 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2192) DUF966 PF06136.8 CDI83322.1 - 0.11 11.9 9.7 0.14 11.5 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SMK-1 PF04802.10 CDI83323.1 - 5.8e-09 35.7 0.9 3.6e-06 26.6 0.1 3.0 3 0 0 3 3 3 2 Component of IIS longevity pathway SMK-1 SR-25 PF10500.4 CDI83323.1 - 0.00037 20.0 7.8 0.00037 20.0 5.4 11.9 10 2 3 13 13 13 3 Nuclear RNA-splicing-associated protein RNA_pol_3_Rpc31 PF11705.3 CDI83323.1 - 0.00078 19.4 14.1 0.00078 19.4 9.7 3.9 3 0 0 3 3 3 2 DNA-directed RNA polymerase III subunit Rpc31 SR-25 PF10500.4 CDI83324.1 - 0.18 11.2 14.9 0.2 11.1 10.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.10 CDI83324.1 - 0.9 10.1 7.2 1 9.9 5.0 1.1 1 0 0 1 1 1 0 Chorion family 2 CAF-1_p150 PF11600.3 CDI83324.1 - 5.7 6.2 10.3 6.2 6.1 7.1 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Sld5 PF05916.6 CDI83325.1 - 0.0068 16.6 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 GINS complex protein Band_3_cyto PF07565.8 CDI83327.1 - 6.6 6.1 25.6 0.63 9.5 4.4 4.0 4 0 0 4 4 4 0 Band 3 cytoplasmic domain RAP PF08373.5 CDI83330.1 - 1.3e-12 47.3 0.0 5.5e-12 45.2 0.0 2.2 1 1 0 1 1 1 1 RAP domain FF PF01846.14 CDI83332.1 - 0.00093 19.0 0.2 1.4 8.9 0.0 2.2 2 0 0 2 2 2 2 FF domain Med15 PF09606.5 CDI83333.1 - 0.0037 15.5 6.1 0.0037 15.5 4.3 3.2 3 0 0 3 3 3 2 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI83333.1 - 0.091 12.4 30.0 0.31 10.7 1.3 3.2 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) DUF2956 PF11169.3 CDI83333.1 - 0.094 12.6 25.4 0.077 12.9 1.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) DUF912 PF06024.7 CDI83333.1 - 1.7 8.7 13.8 4.8 7.2 0.2 3.7 4 0 0 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) FimP PF09766.4 CDI83333.1 - 2.4 7.1 36.1 0.063 12.3 2.1 3.1 3 0 0 3 3 3 0 Fms-interacting protein Zn_peptidase PF04228.8 CDI83333.1 - 4.2 6.5 23.4 0.45 9.7 0.1 3.9 4 0 0 4 4 3 0 Putative neutral zinc metallopeptidase FAM60A PF15396.1 CDI83333.1 - 4.3 7.0 9.2 24 4.6 0.7 3.4 3 0 0 3 3 3 0 Protein Family FAM60A DUF2370 PF10176.4 CDI83333.1 - 4.8 6.4 12.3 0.34 10.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2370) DUF2232 PF09991.4 CDI83333.1 - 6.6 5.6 13.9 1 8.3 0.0 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2232) zf-DHHC PF01529.15 CDI83333.1 - 7.1 5.9 14.8 3.2 7.1 1.1 3.5 3 0 0 3 3 3 0 DHHC palmitoyltransferase BRF1 PF07741.8 CDI83333.1 - 7.4 6.8 21.2 3.3 8.0 0.9 3.5 3 0 0 3 3 3 0 Brf1-like TBP-binding domain APG12 PF04110.8 CDI83334.1 - 6.2e-06 26.3 0.0 1.6e-05 25.0 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like autophagy protein Apg12 Pex14_N PF04695.8 CDI83334.1 - 0.0067 16.4 9.0 0.0067 16.4 6.3 4.4 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_23 PF13476.1 CDI83334.1 - 0.018 15.3 11.5 0.11 12.8 0.3 2.1 2 0 0 2 2 2 0 AAA domain AAA-ATPase_like PF09820.4 CDI83334.1 - 0.26 10.4 4.3 0.48 9.5 0.0 2.1 2 0 0 2 2 2 0 Predicted AAA-ATPase AAA_22 PF13401.1 CDI83334.1 - 0.77 9.9 5.6 0.69 10.0 0.8 2.6 1 1 1 3 3 3 0 AAA domain AAA PF00004.24 CDI83334.1 - 1.6 8.9 4.2 0.94 9.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2228 PF10228.4 CDI83334.1 - 3.4 7.1 8.4 0.057 12.9 0.6 1.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) Helicase_RecD PF05127.9 CDI83334.1 - 7.6 6.1 12.4 0.67 9.5 0.0 2.7 3 0 0 3 3 3 0 Helicase Acetyltransf_1 PF00583.19 CDI83335.1 - 3.5e-05 23.7 3.1 0.0044 17.0 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CDI83335.1 - 0.0042 17.2 0.1 0.035 14.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain M16C_assoc PF08367.6 CDI83335.1 - 0.079 11.7 0.5 0.14 10.9 0.3 1.3 1 0 0 1 1 1 0 Peptidase M16C associated PAT1 PF09770.4 CDI83336.1 - 4.8e-05 21.8 160.2 0.00011 20.6 111.0 1.7 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.8 CDI83337.1 - 1.6 8.7 14.9 0.89 9.6 4.9 2.4 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EF-hand_8 PF13833.1 CDI83338.1 - 0.002 17.6 0.1 0.022 14.3 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 CDI83338.1 - 0.033 14.3 0.2 0.14 12.3 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair COG2 PF06148.6 CDI83338.1 - 0.63 9.9 12.6 3.1 7.6 2.5 3.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Suf PF05843.9 CDI83345.1 - 0.032 13.9 1.1 0.048 13.3 0.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) OATP PF03137.15 CDI83345.1 - 0.034 12.1 0.0 0.034 12.1 0.0 1.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Mem_trans PF03547.13 CDI83345.1 - 0.22 9.7 0.0 0.31 9.2 0.0 1.1 1 0 0 1 1 1 0 Membrane transport protein Agouti PF05039.7 CDI83345.1 - 0.61 10.4 14.5 2.6 8.4 5.3 2.5 2 0 0 2 2 2 0 Agouti protein IMCp PF12314.3 CDI83346.1 - 1.1e-11 44.7 48.6 7.1e-08 32.4 12.2 4.6 2 1 1 3 3 3 2 Inner membrane complex protein Thioredoxin PF00085.15 CDI83347.1 - 1.6e-29 101.6 0.0 2.3e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 CDI83347.1 - 1.7e-08 34.6 0.0 8.6e-08 32.3 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDI83347.1 - 2.9e-05 24.0 0.0 0.00023 21.2 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.1 CDI83347.1 - 0.00013 21.9 0.0 0.00026 20.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_6 PF13848.1 CDI83347.1 - 0.00024 20.9 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.1 CDI83347.1 - 0.0014 18.1 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.1 CDI83347.1 - 0.0021 17.5 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 CDI83347.1 - 0.0046 16.4 0.0 0.0067 15.9 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_3 PF13192.1 CDI83347.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain HyaE PF07449.6 CDI83347.1 - 0.045 13.6 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE JAB PF01398.16 CDI83348.1 - 4.6e-11 42.4 0.0 8e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 CDI83348.1 - 1.6e-08 34.6 0.0 2.5e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function HTH_3 PF01381.17 CDI83348.1 - 0.0035 17.1 0.0 0.01 15.6 0.0 1.8 1 1 1 2 2 2 1 Helix-turn-helix HTH_19 PF12844.2 CDI83348.1 - 0.032 14.2 0.0 0.59 10.2 0.0 2.3 1 1 0 1 1 1 0 Helix-turn-helix domain Apolipoprotein PF01442.13 CDI83348.1 - 0.05 13.1 0.0 0.076 12.5 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Potyvirid-P3 PF13608.1 CDI83349.1 - 0.033 13.3 1.1 0.054 12.6 0.8 1.2 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein Baculo_PEP_C PF04513.7 CDI83349.1 - 1.2 8.9 7.5 0.79 9.5 3.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF489 PF04356.7 CDI83351.1 - 0.00021 20.9 1.3 0.43 10.1 0.1 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF489) TMF_TATA_bd PF12325.3 CDI83351.1 - 0.0047 16.6 18.3 0.055 13.1 6.5 2.5 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding Macoilin PF09726.4 CDI83351.1 - 0.013 13.8 4.7 0.0075 14.6 2.0 1.5 1 1 1 2 2 2 0 Transmembrane protein Flagellin_N PF00669.15 CDI83351.1 - 0.024 14.4 1.2 0.024 14.4 0.9 1.8 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Mto2_bdg PF12808.2 CDI83351.1 - 0.04 14.0 2.5 0.04 14.0 1.7 3.1 3 1 0 3 3 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Vac_Fusion PF02346.11 CDI83351.1 - 0.053 12.9 0.4 0.17 11.3 0.1 2.0 2 0 0 2 2 2 0 Chordopoxvirus fusion protein TMF_DNA_bd PF12329.3 CDI83351.1 - 0.11 12.2 24.2 0.038 13.7 7.3 3.7 1 1 1 2 2 1 0 TATA element modulatory factor 1 DNA binding IncA PF04156.9 CDI83351.1 - 0.18 11.3 20.6 2.4 7.7 14.3 2.0 1 1 0 1 1 1 0 IncA protein DUF1515 PF07439.6 CDI83351.1 - 0.18 11.6 6.4 3.5 7.4 1.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) COG2 PF06148.6 CDI83351.1 - 0.2 11.4 12.7 0.34 10.7 4.4 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 SlyX PF04102.7 CDI83351.1 - 0.28 11.5 15.1 0.094 13.1 1.9 3.2 2 1 1 3 3 3 0 SlyX AAA_13 PF13166.1 CDI83351.1 - 0.3 9.5 8.6 0.48 8.8 6.0 1.4 1 1 0 1 1 1 0 AAA domain DUF342 PF03961.8 CDI83351.1 - 0.35 9.2 7.4 0.13 10.6 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) ATG16 PF08614.6 CDI83351.1 - 0.37 10.6 17.2 0.41 10.4 5.1 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Glutaredoxin2_C PF04399.8 CDI83351.1 - 0.61 9.6 5.8 0.25 10.9 0.3 2.4 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain Bap31 PF05529.7 CDI83351.1 - 0.64 9.4 10.7 0.55 9.6 0.4 2.2 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Fez1 PF06818.10 CDI83351.1 - 0.66 9.9 13.9 1 9.3 9.7 1.2 1 0 0 1 1 1 0 Fez1 YjcZ PF13990.1 CDI83351.1 - 0.81 8.7 8.1 0.13 11.3 1.8 1.9 1 1 1 2 2 2 0 YjcZ-like protein Atg14 PF10186.4 CDI83351.1 - 1.5 7.6 14.7 0.23 10.3 5.7 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 GAS PF13851.1 CDI83351.1 - 1.6 7.9 19.3 28 3.8 13.3 2.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.6 CDI83351.1 - 2.2 6.8 14.3 0.3 9.7 5.9 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4559 PF15112.1 CDI83351.1 - 2.3 7.2 7.0 3.2 6.8 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF3166 PF11365.3 CDI83351.1 - 2.9 8.4 11.1 0.85 10.1 2.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3166) TMCO5 PF14992.1 CDI83351.1 - 2.9 6.9 15.6 0.11 11.6 0.6 2.1 1 1 1 2 2 2 0 TMCO5 family DUF972 PF06156.8 CDI83351.1 - 2.9 8.2 14.0 0.68 10.2 4.5 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF1732 PF08340.6 CDI83351.1 - 3.1 7.6 7.3 1.1 9.1 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1732) TPR_MLP1_2 PF07926.7 CDI83351.1 - 5 6.8 16.4 5 6.8 6.1 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIC PF04977.10 CDI83351.1 - 5 6.6 17.2 0.11 11.9 3.2 3.1 2 1 1 3 3 3 0 Septum formation initiator Mnd1 PF03962.10 CDI83351.1 - 5.1 6.7 13.1 1.6e+02 1.8 9.1 2.1 1 1 0 1 1 1 0 Mnd1 family UPF0184 PF03670.8 CDI83351.1 - 7.3 6.8 6.9 3.9 7.7 0.3 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) CENP-F_leu_zip PF10473.4 CDI83351.1 - 7.7 6.3 21.8 11 5.8 15.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CDC37_N PF03234.9 CDI83351.1 - 8.7 6.6 9.5 8.1 6.7 1.3 1.9 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding TBPIP PF07106.8 CDI83351.1 - 9.6 5.7 15.3 2.9 7.4 5.4 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HAD PF12710.2 CDI83352.1 - 1.6e-09 38.2 0.0 4.4e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDI83352.1 - 5.5e-08 33.4 0.0 4.3e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDI83352.1 - 4.8e-07 29.6 0.2 0.00023 20.8 0.0 3.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDI83352.1 - 7.1e-07 29.1 0.0 2.5e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD_2 PF13419.1 CDI83352.1 - 0.015 15.5 0.1 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pkip-1 PF06878.6 CDI83352.1 - 0.067 13.0 0.2 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Pkip-1 protein S6PP PF05116.8 CDI83352.1 - 0.073 12.3 0.0 0.2 10.8 0.0 1.7 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase Acetyltransf_11 PF13720.1 CDI83352.1 - 0.13 12.4 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 HAD PF12710.2 CDI83353.1 - 0.019 15.1 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase zf-C4H2 PF10146.4 CDI83353.1 - 0.71 9.8 6.7 0.73 9.8 0.5 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein Macoilin PF09726.4 CDI83353.1 - 1 7.5 7.9 1.7 6.8 5.5 1.4 1 0 0 1 1 1 0 Transmembrane protein DUF2360 PF10152.4 CDI83353.1 - 4.4 7.5 16.0 2.8 8.2 1.3 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) YscJ_FliF_C PF08345.6 CDI83355.1 - 4.8 7.1 12.4 0.082 12.8 3.5 1.8 2 0 0 2 2 2 0 Flagellar M-ring protein C-terminal Ribosomal_60s PF00428.14 CDI83356.1 - 0.008 16.5 11.3 0.008 16.5 7.8 9.5 8 1 0 8 8 8 3 60s Acidic ribosomal protein CRT10 PF08728.5 CDI83356.1 - 0.12 10.3 10.4 0.18 9.7 7.2 1.2 1 0 0 1 1 1 0 CRT10 Aminotran_4 PF01063.14 CDI83357.1 - 3.5e-13 49.5 0.0 3.5e-13 49.5 0.0 2.5 2 1 1 3 3 3 1 Aminotransferase class IV DUF3801 PF12687.2 CDI83357.1 - 0.065 12.8 0.1 0.065 12.8 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3801) Cwf_Cwc_15 PF04889.7 CDI83357.1 - 0.75 9.4 30.9 1.6 8.3 14.8 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PAT1 PF09770.4 CDI83357.1 - 2.6 6.2 82.8 2.1 6.4 7.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Pkinase PF00069.20 CDI83359.1 - 2.2e-16 59.7 0.0 4.3e-08 32.6 0.0 3.5 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83359.1 - 0.00055 19.0 0.0 0.0022 17.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase PP2C PF00481.16 CDI83360.1 - 5.1e-27 94.8 8.6 1.1e-16 61.0 0.2 4.6 4 1 0 5 5 5 3 Protein phosphatase 2C AAA_23 PF13476.1 CDI83360.1 - 1.7 8.9 12.1 1.7 8.9 0.7 2.5 2 0 0 2 2 2 0 AAA domain Plasmodium_Vir PF05795.6 CDI83360.1 - 2 7.5 5.0 0.87 8.7 0.6 2.5 2 0 0 2 2 2 0 Plasmodium vivax Vir protein SPX PF03105.14 CDI83361.1 - 2e-06 27.7 10.2 2e-06 27.7 7.1 8.5 4 3 1 5 5 5 1 SPX domain zf-C3HC4_4 PF15227.1 CDI83361.1 - 4.7e-06 26.3 7.7 4.7e-06 26.3 5.3 4.4 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING DUF2453 PF10507.4 CDI83361.1 - 0.46 10.3 0.0 0.46 10.3 0.0 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF2453) DUF1754 PF08555.5 CDI83363.1 - 0.00031 21.2 0.2 0.00031 21.2 0.1 2.7 2 1 1 3 3 3 1 Eukaryotic family of unknown function (DUF1754) MSP1_C PF07462.6 CDI83363.1 - 0.046 12.1 17.8 0.071 11.5 2.7 2.1 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus SR-25 PF10500.4 CDI83364.1 - 0.0013 18.2 9.9 0.0013 18.2 6.9 1.5 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.14 CDI83364.1 - 0.03 14.7 11.1 0.03 14.7 7.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4207 PF13904.1 CDI83364.1 - 0.053 12.8 10.6 0.076 12.3 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) SbcD_C PF12320.3 CDI83364.1 - 0.19 11.7 4.0 0.32 11.0 2.8 1.2 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain Suf PF05843.9 CDI83364.1 - 1.2 8.8 5.3 1.5 8.5 3.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CAF-1_p150 PF11600.3 CDI83364.1 - 2.3 7.5 14.4 3.5 6.9 10.0 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal AP2 PF00847.15 CDI83365.1 - 7.9e-08 32.3 0.8 7.9e-08 32.3 0.6 3.2 2 0 0 2 2 2 1 AP2 domain TSP_1 PF00090.14 CDI83366.1 - 3.8 7.7 24.4 0.26 11.4 4.6 5.2 5 0 0 5 5 5 0 Thrombospondin type 1 domain Abhydrolase_5 PF12695.2 CDI83367.1 - 2.4e-05 24.1 0.1 2.4e-05 24.1 0.1 4.2 2 2 2 4 4 4 1 Alpha/beta hydrolase family Ycf1 PF05758.7 CDI83367.1 - 0.2 9.3 15.6 0.018 12.8 3.7 2.3 2 0 0 2 2 2 0 Ycf1 Rtf2 PF04641.7 CDI83369.1 - 4.9 6.2 9.9 1.1 8.3 3.8 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger FH2 PF02181.18 CDI83370.1 - 4.9e-39 134.2 0.0 8.9e-29 100.5 0.0 2.8 2 0 0 2 2 2 2 Formin Homology 2 Domain Bromodomain PF00439.20 CDI83371.1 - 1.3e-10 41.0 0.0 2.3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Bromodomain CDK2AP PF09806.4 CDI83371.1 - 0.00097 19.4 9.2 0.0018 18.5 6.4 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein BAF1_ABF1 PF04684.8 CDI83371.1 - 0.014 14.2 1.1 0.019 13.8 0.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CbiD PF01888.12 CDI83371.1 - 0.41 9.5 2.2 0.69 8.8 1.5 1.2 1 0 0 1 1 1 0 CbiD Ribosomal_60s PF00428.14 CDI83372.1 - 0.013 15.9 0.7 0.015 15.7 0.5 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein PNK3P PF08645.6 CDI83377.1 - 2e-38 131.3 0.0 6.7e-24 84.1 0.0 2.4 2 0 0 2 2 2 2 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 CDI83377.1 - 1.5e-14 54.0 0.3 9.7e-14 51.4 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDI83377.1 - 3.8e-05 23.7 0.0 9.3e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CDI83377.1 - 7e-05 22.9 0.0 0.00022 21.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 CDI83377.1 - 7.4e-05 22.0 1.0 0.14 11.3 0.1 2.5 1 1 1 2 2 2 2 Chromatin associated protein KTI12 tRNA_lig_kinase PF08303.6 CDI83377.1 - 0.00015 21.7 1.2 0.00015 21.6 0.0 1.7 2 0 0 2 2 1 1 tRNA ligase kinase domain Zeta_toxin PF06414.7 CDI83377.1 - 0.00016 20.8 0.3 0.0072 15.4 0.1 2.3 1 1 0 2 2 2 1 Zeta toxin HAD_2 PF13419.1 CDI83377.1 - 0.00074 19.7 0.2 0.2 11.8 0.0 3.1 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase DUF258 PF03193.11 CDI83377.1 - 0.0011 18.1 0.0 0.0021 17.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 CDI83377.1 - 0.0024 18.6 0.0 0.0055 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CDI83377.1 - 0.0039 17.1 0.0 0.009 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDI83377.1 - 0.0044 17.3 0.2 0.026 14.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDI83377.1 - 0.006 16.0 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.9 CDI83377.1 - 0.012 15.3 0.0 0.032 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) cobW PF02492.14 CDI83377.1 - 0.015 14.7 0.2 0.068 12.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 CDI83377.1 - 0.019 13.7 0.0 0.029 13.1 0.0 1.3 1 0 0 1 1 1 0 ArgK protein ABC_tran PF00005.22 CDI83377.1 - 0.02 15.1 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter G-alpha PF00503.15 CDI83377.1 - 0.022 13.4 4.8 0.035 12.8 3.3 1.4 1 1 0 1 1 1 0 G-protein alpha subunit MMR_HSR1 PF01926.18 CDI83377.1 - 0.024 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.7 CDI83377.1 - 0.037 13.6 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.1 CDI83377.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain Miro PF08477.8 CDI83377.1 - 0.046 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein HAD PF12710.2 CDI83377.1 - 0.052 13.7 0.1 3.4 7.7 0.4 2.5 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase AAA_14 PF13173.1 CDI83377.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CDI83377.1 - 0.065 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain 6PF2K PF01591.13 CDI83377.1 - 0.11 11.5 0.1 2.5 7.1 0.0 2.2 1 1 1 2 2 2 0 6-phosphofructo-2-kinase V-ATPase_G PF03179.10 CDI83379.1 - 2.8e-09 37.1 7.8 6.7e-09 35.9 5.4 1.6 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit HrpE PF06188.7 CDI83379.1 - 0.058 13.1 10.1 0.04 13.6 3.5 2.2 1 1 1 2 2 2 0 HrpE/YscL/FliH and V-type ATPase subunit E DUF3552 PF12072.3 CDI83379.1 - 0.16 11.1 12.2 0.28 10.3 8.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) STAT_int PF02865.12 CDI83379.1 - 0.19 11.7 3.9 0.15 11.9 1.3 1.8 2 0 0 2 2 2 0 STAT protein, protein interaction domain ATP-synt_B PF00430.13 CDI83379.1 - 3.4 7.4 16.4 0.14 11.9 7.2 1.8 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) DUF4233 PF14017.1 CDI83380.1 - 1.4 8.8 10.5 0.062 13.2 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4233) DUF983 PF06170.7 CDI83380.1 - 8.2 6.6 13.1 7 6.8 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF983) DUF3633 PF12315.3 CDI83382.1 - 3.5e-10 39.5 5.6 1.1e-06 28.1 0.1 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3633) HCMV_UL139 PF12507.3 CDI83382.1 - 1.1 9.4 10.9 0.095 12.8 1.4 2.9 3 0 0 3 3 3 0 Human Cytomegalovirus UL139 protein Ribosomal_60s PF00428.14 CDI83383.1 - 9.1e-06 25.9 6.5 9.1e-06 25.9 4.5 13.4 12 2 2 14 14 14 4 60s Acidic ribosomal protein RAB3GAP2_N PF14655.1 CDI83383.1 - 0.0029 16.6 9.6 0.0029 16.6 6.6 2.9 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus ING PF12998.2 CDI83384.1 - 0.0015 18.7 0.0 0.0015 18.7 0.0 2.3 2 1 0 2 2 1 1 Inhibitor of growth proteins N-terminal histone-binding FimP PF09766.4 CDI83384.1 - 0.0041 16.2 9.5 0.007 15.4 6.6 1.3 1 0 0 1 1 1 1 Fms-interacting protein RAB3GAP2_N PF14655.1 CDI83384.1 - 0.0092 15.0 3.4 0.0093 15.0 2.3 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus SR-25 PF10500.4 CDI83384.1 - 0.012 15.1 14.1 0.23 10.9 2.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein eIF3g PF12353.3 CDI83384.1 - 0.028 14.3 4.1 0.057 13.3 2.9 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Suf PF05843.9 CDI83384.1 - 0.028 14.1 8.5 0.036 13.7 5.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3801 PF12687.2 CDI83384.1 - 0.041 13.4 6.9 0.069 12.7 4.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3801) TFIIA PF03153.8 CDI83384.1 - 0.043 13.7 13.3 0.054 13.3 9.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.3 CDI83384.1 - 0.084 12.1 19.7 0.13 11.6 13.7 1.3 1 0 0 1 1 1 0 SprA-related family Eaf7 PF07904.8 CDI83384.1 - 0.09 12.7 1.3 0.44 10.5 0.0 2.1 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 zf-DHHC PF01529.15 CDI83384.1 - 0.094 12.1 0.8 0.091 12.1 0.6 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase PAT1 PF09770.4 CDI83384.1 - 0.097 10.8 20.2 0.11 10.7 14.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDI83384.1 - 0.11 10.7 26.8 0.13 10.4 18.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF755 PF05501.6 CDI83384.1 - 0.19 11.7 23.9 0.66 10.0 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Dynamin_N PF00350.18 CDI83384.1 - 0.29 10.9 2.8 0.12 12.1 0.5 1.4 2 0 0 2 2 2 0 Dynamin family Serinc PF03348.10 CDI83384.1 - 0.53 8.9 4.1 0.51 8.9 2.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Cryptochrome_C PF12546.3 CDI83384.1 - 0.58 10.8 16.2 0.25 12.0 5.7 2.1 2 0 0 2 2 2 0 Blue/Ultraviolet sensing protein C terminal AAA_23 PF13476.1 CDI83384.1 - 0.73 10.1 7.3 0.88 9.8 5.1 1.2 1 0 0 1 1 1 0 AAA domain DUF4557 PF15101.1 CDI83384.1 - 0.76 9.5 14.7 0.14 11.9 7.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) FCP1_C PF09309.5 CDI83384.1 - 0.82 8.9 14.2 0.35 10.1 6.5 2.0 2 0 0 2 2 2 0 FCP1, C-terminal G0-G1_switch_2 PF15103.1 CDI83384.1 - 8.4 6.6 12.8 1.3 9.2 5.9 1.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 CAF1C_H4-bd PF12265.3 CDI83387.1 - 2.8e-13 49.5 0.0 5.5e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 CDI83387.1 - 1.2e-06 28.1 22.4 0.031 14.1 0.0 6.7 6 1 0 6 6 6 5 WD domain, G-beta repeat Symplekin_C PF12295.3 CDI83388.1 - 5.9e-24 84.9 0.0 1.4e-23 83.7 0.0 1.7 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal RAP1 PF07218.6 CDI83389.1 - 0.0013 16.9 4.5 0.0013 16.9 3.1 1.8 2 0 0 2 2 2 1 Rhoptry-associated protein 1 (RAP-1) Corona_nucleoca PF00937.13 CDI83389.1 - 0.042 12.7 1.2 0.068 12.1 0.9 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RseC_MucC PF04246.7 CDI83389.1 - 3.6 7.1 12.2 0.15 11.6 3.1 2.4 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF4228 PF14009.1 CDI83390.1 - 0.42 10.7 3.0 0.5 10.4 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) TFIIA PF03153.8 CDI83390.1 - 9.5 6.0 12.4 11 5.8 8.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RED_N PF07808.8 CDI83391.1 - 0.0048 16.1 5.5 0.0087 15.3 3.8 1.3 1 0 0 1 1 1 1 RED-like protein N-terminal region Peptidase_M19 PF01244.16 CDI83391.1 - 0.2 10.5 1.1 0.3 9.9 0.8 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) DUF4207 PF13904.1 CDI83391.1 - 3.1 7.0 14.6 5.1 6.3 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) IncA PF04156.9 CDI83391.1 - 4.6 6.8 20.4 2.1 7.9 9.7 2.6 2 1 0 2 2 2 0 IncA protein Mnd1 PF03962.10 CDI83391.1 - 6.2 6.4 11.5 17 4.9 8.0 1.8 1 1 0 1 1 1 0 Mnd1 family TMPIT PF07851.8 CDI83391.1 - 8.9 5.2 7.9 13 4.7 5.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein RAP1 PF07218.6 CDI83392.1 - 1.1 7.2 13.0 1.7 6.6 9.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAT1 PF09770.4 CDI83392.1 - 1.6 6.8 26.5 2.4 6.3 18.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pkinase PF00069.20 CDI83394.1 - 1.3e-19 70.3 0.1 5.3e-10 38.8 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83394.1 - 8e-09 34.9 0.1 0.0039 16.2 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase NUDIX PF00293.23 CDI83396.1 - 1.8e-14 53.5 0.0 4e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DCP2 PF05026.8 CDI83396.1 - 2.6e-14 52.8 1.9 2.6e-14 52.8 1.3 2.7 3 0 0 3 3 3 1 Dcp2, box A domain LsmAD PF06741.8 CDI83396.1 - 0.0011 18.9 1.6 0.0011 18.9 1.1 2.9 4 0 0 4 4 4 1 LsmAD domain Peptidase_S9 PF00326.16 CDI83399.1 - 3.3e-15 55.9 7.5 9.4e-07 28.2 3.2 3.9 3 0 0 3 3 3 2 Prolyl oligopeptidase family IncA PF04156.9 CDI83399.1 - 0.00021 20.9 19.1 0.00021 20.9 13.2 9.3 8 2 0 8 8 8 1 IncA protein OmpH PF03938.9 CDI83399.1 - 0.0049 16.8 29.2 0.0049 16.8 20.2 10.2 8 2 1 9 9 9 2 Outer membrane protein (OmpH-like) Pex14_N PF04695.8 CDI83399.1 - 0.0065 16.5 15.1 0.0065 16.5 10.5 11.3 10 2 0 10 10 10 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Cellulose_synt PF03552.9 CDI83399.1 - 1.4 7.0 5.1 3 6.0 3.5 1.4 1 0 0 1 1 1 0 Cellulose synthase Ycf1 PF05758.7 CDI83399.1 - 5 4.7 21.4 0.0052 14.5 4.7 3.0 3 0 0 3 3 3 0 Ycf1 Cyclin PF08613.6 CDI83402.1 - 1.2e-28 100.3 0.0 3.1e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CDI83402.1 - 7e-06 25.6 0.0 7e-06 25.6 0.0 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain dCMP_cyt_deam_2 PF08211.6 CDI83402.1 - 0.13 12.2 0.0 0.13 12.2 0.0 2.3 3 0 0 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region SNF2_N PF00176.18 CDI83405.1 - 1.6e-17 63.2 0.0 3.4e-15 55.6 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain zf-C4_Topoisom PF01396.14 CDI83405.1 - 1.3e-08 34.2 3.1 4e-08 32.6 2.1 1.8 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger HNH PF01844.18 CDI83405.1 - 1.8e-05 24.5 0.1 4.8e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 HNH endonuclease Helicase_C PF00271.26 CDI83405.1 - 0.0062 16.3 0.8 0.014 15.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDI83405.1 - 0.12 12.4 0.0 0.42 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain DDHD PF02862.12 CDI83407.1 - 0.32 10.7 8.4 0.37 10.5 5.8 1.2 1 0 0 1 1 1 0 DDHD domain DUF1510 PF07423.6 CDI83407.1 - 7.5 5.8 28.0 9.5 5.5 19.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Glyco_tran_28_C PF04101.11 CDI83408.1 - 7.7e-16 58.1 0.0 1.7e-15 57.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain IER PF05760.7 CDI83408.1 - 1.5 8.6 6.8 0.37 10.6 0.3 2.0 2 0 0 2 2 2 0 Immediate early response protein (IER) WD40 PF00400.27 CDI83410.1 - 0.0046 16.7 0.2 0.0046 16.7 0.1 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat Pex14_N PF04695.8 CDI83410.1 - 0.0066 16.4 5.9 0.2 11.6 1.9 2.4 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.9 CDI83410.1 - 1.8 8.2 8.4 0.078 12.6 2.1 1.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Ycf1 PF05758.7 CDI83411.1 - 2.9 5.4 4.3 4.3 4.9 3.0 1.2 1 0 0 1 1 1 0 Ycf1 Helicase_C PF00271.26 CDI83412.1 - 1.5e-07 31.1 0.2 3.9e-07 29.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDI83412.1 - 7.6e-05 22.2 0.1 0.00032 20.2 0.2 2.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.1 CDI83412.1 - 0.00086 19.0 0.8 0.0055 16.4 0.2 2.7 3 0 0 3 3 3 1 Part of AAA domain ABC_tran PF00005.22 CDI83412.1 - 0.077 13.2 0.2 0.82 9.9 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Arch_ATPase PF01637.13 CDI83412.1 - 0.23 11.1 0.0 0.43 10.2 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase AAA_23 PF13476.1 CDI83412.1 - 5.5 7.2 8.9 1.1 9.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain ABC1 PF03109.11 CDI83413.1 - 0.012 15.6 0.6 1.8 8.5 0.1 2.6 1 1 1 2 2 2 0 ABC1 family RNA_GG_bind PF10258.4 CDI83414.1 - 2.3e-22 78.4 0.0 4.5e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain DUF998 PF06197.8 CDI83415.1 - 4.9 6.4 18.9 37 3.5 12.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF998) SNF2_N PF00176.18 CDI83416.1 - 7.4e-41 139.8 0.0 1.2e-36 126.0 0.0 2.1 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 CDI83416.1 - 4.6e-10 39.2 0.0 9.4e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI83416.1 - 0.0018 18.1 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 CDI83416.1 - 0.031 13.2 0.0 0.056 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.24 CDI83416.1 - 0.067 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase MA3 PF02847.12 CDI83417.1 - 0.0026 17.4 0.2 0.011 15.4 0.0 2.2 2 0 0 2 2 2 1 MA3 domain KSR1-SAM PF13543.1 CDI83417.1 - 0.0041 16.9 0.1 0.01 15.6 0.1 1.6 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 Vps51 PF08700.6 CDI83418.1 - 0.00095 18.9 0.3 0.0032 17.2 0.0 2.0 2 0 0 2 2 2 1 Vps51/Vps67 Glycos_transf_1 PF00534.15 CDI83420.1 - 1.6e-14 53.7 0.0 5.7e-13 48.6 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CDI83420.1 - 0.0033 17.1 0.0 0.0069 16.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 tRNA-synt_2b PF00587.20 CDI83421.1 - 4.1e-25 88.3 0.0 5.5e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 CDI83421.1 - 0.19 10.4 0.0 0.3 9.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Kinesin PF00225.18 CDI83422.1 - 1e-78 264.4 0.9 2.3e-76 256.6 0.6 2.4 1 1 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 CDI83422.1 - 0.052 13.6 0.0 1.1 9.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF2622 PF11080.3 CDI83422.1 - 0.069 13.0 0.0 0.33 10.8 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2622) P5CR_dimer PF14748.1 CDI83423.1 - 1.1e-29 102.6 0.0 1.9e-29 101.7 0.0 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 CDI83423.1 - 0.00086 19.6 2.2 0.53 10.7 0.9 2.4 1 1 1 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent DNA_mis_repair PF01119.14 CDI83425.1 - 3.6e-13 49.0 0.0 6.1e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.6 CDI83425.1 - 5.1e-12 45.5 10.3 6.4e-11 42.0 0.0 4.8 5 1 1 6 6 6 2 MutL C terminal dimerisation domain HATPase_c PF02518.21 CDI83425.1 - 7.9e-10 38.4 0.0 2e-09 37.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 CDI83425.1 - 1.7e-08 34.1 0.0 5.1e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BAF1_ABF1 PF04684.8 CDI83426.1 - 0.29 9.9 8.7 0.44 9.3 6.0 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Pex14_N PF04695.8 CDI83426.1 - 0.66 10.0 13.6 0.92 9.5 2.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAN_4 PF14295.1 CDI83427.1 - 1.9e-05 24.2 0.8 3.4e-05 23.4 0.5 1.4 1 0 0 1 1 1 1 PAN domain Band_3_cyto PF07565.8 CDI83427.1 - 0.52 9.7 45.8 2.9 7.3 6.3 3.7 3 0 0 3 3 3 0 Band 3 cytoplasmic domain WD40 PF00400.27 CDI83428.1 - 5.9e-18 63.9 15.4 1.8e-05 24.4 0.0 7.5 8 0 0 8 8 8 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 CDI83428.1 - 0.07 12.9 0.0 9.4 6.0 0.0 2.8 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Med16 PF11635.3 CDI83428.1 - 0.13 10.2 0.0 0.65 7.8 0.0 1.9 2 1 1 3 3 3 0 Mediator complex subunit 16 eIF2A PF08662.6 CDI83428.1 - 0.26 10.9 0.0 0.49 10.0 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A DUF4557 PF15101.1 CDI83428.1 - 0.37 10.5 7.0 0.68 9.7 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) P16-Arc PF04699.9 CDI83428.1 - 0.53 10.3 2.7 1.1 9.2 1.8 1.4 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Suf PF05843.9 CDI83428.1 - 0.8 9.3 5.4 1.5 8.5 3.8 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Brr6_like_C_C PF10104.4 CDI83429.1 - 1.9e-20 72.7 0.0 1.9e-20 72.7 0.0 2.9 4 1 1 5 5 5 1 Di-sulfide bridge nucleocytoplasmic transport domain Activator_LAG-3 PF11498.3 CDI83429.1 - 0.0016 17.3 12.3 0.0016 17.3 8.5 4.1 3 1 0 3 3 3 1 Transcriptional activator LAG-3 DUF2973 PF11189.3 CDI83429.1 - 0.61 9.9 0.0 0.61 9.9 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2973) TFIIA PF03153.8 CDI83429.1 - 4.3 7.1 64.3 0.31 10.8 10.3 2.3 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Sua5_yciO_yrdC PF01300.13 CDI83430.1 - 1.1e-31 109.5 0.1 4.3e-15 55.3 0.1 3.8 1 1 0 2 2 2 2 Telomere recombination SUA5 PF03481.8 CDI83430.1 - 0.00084 19.4 8.3 0.0062 16.6 5.8 2.5 1 1 0 1 1 1 1 Putative GTP-binding controlling metal-binding AAA_23 PF13476.1 CDI83430.1 - 0.078 13.2 9.5 4.7 7.4 4.8 2.2 2 0 0 2 2 2 0 AAA domain Parvo_coat PF00740.13 CDI83430.1 - 3.6 6.4 13.6 1.3 7.9 3.4 2.4 3 0 0 3 3 3 0 Parvovirus coat protein VP2 DUF755 PF05501.6 CDI83431.1 - 0.003 17.6 21.5 0.003 17.6 14.9 8.9 7 2 2 9 9 9 2 Domain of unknown function (DUF755) F-box-like PF12937.2 CDI83431.1 - 0.0057 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like zf-RING_2 PF13639.1 CDI83432.1 - 2.1e-14 53.0 4.7 2.1e-14 53.0 3.3 2.8 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDI83432.1 - 1.2e-09 38.0 2.6 1.2e-09 38.0 1.8 2.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDI83432.1 - 4.5e-09 36.2 3.3 4.5e-09 36.2 2.3 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CDI83432.1 - 2.3e-07 30.3 4.2 2.3e-07 30.3 2.9 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI83432.1 - 2.4e-07 30.3 3.1 2.4e-07 30.3 2.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CDI83432.1 - 3.3e-07 29.8 4.4 3.3e-07 29.8 3.1 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDI83432.1 - 0.0012 18.5 0.3 0.0012 18.5 0.2 1.9 2 1 0 2 2 1 1 RING-type zinc-finger Prok-RING_1 PF14446.1 CDI83432.1 - 0.0027 17.3 0.4 0.0027 17.3 0.3 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.1 CDI83432.1 - 0.067 12.7 5.1 0.19 11.3 3.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C2HC_2 PF13913.1 CDI83432.1 - 0.14 11.8 0.0 0.14 11.8 0.0 3.2 3 0 0 3 3 2 0 zinc-finger of a C2HC-type zf-Apc11 PF12861.2 CDI83432.1 - 0.16 11.8 10.7 0.044 13.6 4.3 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.7 CDI83432.1 - 0.19 10.9 3.8 0.2 10.8 2.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger RINGv PF12906.2 CDI83432.1 - 0.23 11.5 7.6 0.28 11.2 4.6 1.8 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 CDI83432.1 - 0.35 10.8 11.8 15 5.6 7.7 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.24 CDI83432.1 - 1.4 8.6 10.7 0.047 13.3 2.6 2.2 2 1 0 2 2 2 0 PHD-finger Baculo_IE-1 PF05290.6 CDI83432.1 - 3.8 7.2 10.0 6.7 6.4 6.9 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) STOP PF05217.7 CDI83434.1 - 2.1e-33 115.8 9.9 3.7e-22 79.1 2.3 2.2 1 1 1 2 2 2 2 STOP protein PDEase_I PF00233.14 CDI83435.1 - 4.2e-42 144.5 0.5 3.1e-40 138.4 0.0 2.4 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase DUF4512 PF14975.1 CDI83435.1 - 0.18 12.6 4.0 1.3 9.9 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4512) Dot_icm_IcmQ PF09475.5 CDI83435.1 - 0.24 10.6 0.6 0.45 9.7 0.4 1.3 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) SET PF00856.23 CDI83436.1 - 1.6e-06 28.5 0.6 0.00066 20.0 0.2 2.8 3 1 0 3 3 3 2 SET domain RNB PF00773.14 CDI83438.1 - 1.3e-60 205.3 20.3 7.9e-47 160.1 0.0 6.3 5 2 0 5 5 5 2 RNB domain SAGA-Tad1 PF12767.2 CDI83439.1 - 0.22 11.1 31.9 1.1 8.9 3.1 2.1 1 1 1 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit STAS_2 PF13466.1 CDI83440.1 - 2.7 8.0 8.5 2 8.5 2.2 2.6 2 1 0 2 2 2 0 STAS domain Dpy-30 PF05186.8 CDI83442.1 - 8.6 5.9 8.0 28 4.3 0.1 3.2 3 0 0 3 3 3 0 Dpy-30 motif DUF3357 PF11837.3 CDI83444.1 - 0.027 14.3 0.5 1.3 8.8 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3357) FimP PF09766.4 CDI83444.1 - 0.099 11.6 5.0 0.15 11.1 3.5 1.2 1 0 0 1 1 1 0 Fms-interacting protein DUF1007 PF06226.8 CDI83444.1 - 2 8.0 10.5 0.37 10.5 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1007) DUF788 PF05620.6 CDI83444.1 - 3 7.6 4.5 6.3 6.6 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Activator_LAG-3 PF11498.3 CDI83444.1 - 3.6 6.2 22.1 6.9 5.2 15.3 1.4 1 1 0 1 1 1 0 Transcriptional activator LAG-3 OmpH PF03938.9 CDI83445.1 - 1.2e-07 31.7 26.8 1.2e-07 31.7 18.6 5.7 5 0 0 5 5 5 2 Outer membrane protein (OmpH-like) RCC1 PF00415.13 CDI83445.1 - 4.9e-07 29.8 0.1 0.15 12.2 0.0 4.6 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat IncA PF04156.9 CDI83445.1 - 2.2e-06 27.4 15.1 2.2e-06 27.4 10.5 6.1 5 1 0 5 5 5 1 IncA protein RCC1_2 PF13540.1 CDI83445.1 - 1.5e-05 24.4 0.2 1.5e-05 24.4 0.1 5.0 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ycf1 PF05758.7 CDI83445.1 - 0.00068 17.5 5.2 0.00068 17.5 3.6 4.1 4 1 0 4 4 4 1 Ycf1 LMBR1 PF04791.11 CDI83445.1 - 0.086 11.4 8.5 0.44 9.0 0.2 2.3 2 0 0 2 2 2 0 LMBR1-like membrane protein Peptidase_C2 PF00648.16 CDI83446.1 - 0.002 17.1 0.0 0.0038 16.2 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease zf-DHHC PF01529.15 CDI83446.1 - 0.079 12.3 4.6 7.6 5.8 0.1 3.7 4 0 0 4 4 4 0 DHHC palmitoyltransferase RICTOR_N PF14664.1 CDI83446.1 - 6.6 5.2 1.7 13 4.2 1.2 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Pkinase PF00069.20 CDI83447.1 - 1.6e-10 40.5 0.0 4e-10 39.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83447.1 - 9.8e-07 28.1 0.0 2e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Rotamase_2 PF13145.1 CDI83451.1 - 0.013 16.1 0.6 0.016 15.8 0.4 1.1 1 0 0 1 1 1 0 PPIC-type PPIASE domain Strep_SA_rep PF06696.6 CDI83451.1 - 0.076 12.7 0.4 0.19 11.4 0.3 1.7 1 0 0 1 1 1 0 Streptococcal surface antigen repeat SR-25 PF10500.4 CDI83452.1 - 0.0029 17.0 8.4 0.0029 17.0 5.9 9.0 5 2 3 8 8 8 2 Nuclear RNA-splicing-associated protein DUF3801 PF12687.2 CDI83453.1 - 0.00014 21.5 26.1 0.0035 16.9 3.4 3.9 3 0 0 3 3 3 3 Protein of unknown function (DUF3801) Vps53_N PF04100.7 CDI83454.1 - 9.1e-45 153.0 21.4 3.3e-30 105.1 0.8 4.1 2 2 1 3 3 3 2 Vps53-like, N-terminal CDK2AP PF09806.4 CDI83454.1 - 0.044 14.0 0.0 0.044 14.0 0.0 9.1 4 4 3 7 7 7 0 Cyclin-dependent kinase 2-associated protein OmpH PF03938.9 CDI83454.1 - 0.054 13.4 0.0 0.054 13.4 0.0 5.5 3 2 0 3 3 3 0 Outer membrane protein (OmpH-like) Zip PF02535.17 CDI83454.1 - 0.16 10.9 15.8 0.25 10.3 5.9 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter RNA_pol_Rpb1_5 PF04998.12 CDI83454.1 - 0.52 9.5 10.2 2 7.6 3.5 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 5 GARS_C PF02843.11 CDI83454.1 - 1.2 9.3 12.6 2.7 8.2 0.3 3.2 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, C domain Ycf1 PF05758.7 CDI83454.1 - 2.5 5.7 23.4 1.6 6.3 5.2 2.2 2 0 0 2 2 2 0 Ycf1 Chorion_2 PF03964.10 CDI83455.1 - 0.016 15.7 1.8 0.016 15.7 1.3 10.7 3 2 5 9 9 9 0 Chorion family 2 Mit_KHE1 PF10173.4 CDI83455.1 - 0.019 14.8 0.3 0.019 14.8 0.2 3.2 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related Med15 PF09606.5 CDI83457.1 - 0.00032 19.0 63.5 0.00032 19.0 44.0 6.7 5 1 1 6 6 6 3 ARC105 or Med15 subunit of Mediator complex non-fungal RRM_5 PF13893.1 CDI83457.1 - 0.0099 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyoxalase_2 PF12681.2 CDI83458.1 - 1.5e-05 25.5 0.2 0.07 13.7 0.0 3.5 3 1 0 3 3 3 2 Glyoxalase-like domain Glyoxalase PF00903.20 CDI83458.1 - 0.0034 17.3 0.0 0.017 15.1 0.0 2.2 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily IF3_C PF00707.17 CDI83459.1 - 1e-18 66.7 0.0 1e-18 66.7 0.0 2.0 3 0 0 3 3 3 1 Translation initiation factor IF-3, C-terminal domain OATP PF03137.15 CDI83459.1 - 7.5 4.4 8.4 13 3.6 0.0 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DCP1 PF06058.8 CDI83460.1 - 7.4e-13 48.6 0.0 2.5e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 Dcp1-like decapping family Bud13 PF09736.4 CDI83460.1 - 3.3 7.9 36.2 0.19 11.9 9.4 3.1 3 0 0 3 3 3 0 Pre-mRNA-splicing factor of RES complex GSH_synth_ATP PF03917.12 CDI83461.1 - 6e-45 153.4 0.0 7.3e-24 84.0 0.0 6.6 4 2 0 4 4 4 3 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 CDI83461.1 - 1.3e-10 41.2 9.1 2.7e-09 37.0 0.4 3.2 3 0 0 3 3 3 2 Eukaryotic glutathione synthase DUF755 PF05501.6 CDI83461.1 - 0.0028 17.6 0.9 0.0028 17.6 0.6 7.2 6 1 1 7 7 7 1 Domain of unknown function (DUF755) DUF912 PF06024.7 CDI83461.1 - 0.075 13.0 10.0 1.6 8.8 0.0 4.4 5 0 0 5 5 5 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-C3HC4 PF00097.20 CDI83464.1 - 0.067 12.8 0.5 0.15 11.7 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LSM PF01423.17 CDI83465.1 - 3.7e-16 58.4 0.3 4.5e-16 58.1 0.2 1.2 1 0 0 1 1 1 1 LSM domain SPC22 PF04573.7 CDI83466.1 - 9.6e-36 122.6 0.0 1.3e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Signal peptidase subunit TSA PF03249.8 CDI83466.1 - 0.03 12.8 2.0 0.043 12.3 1.4 1.2 1 0 0 1 1 1 0 Type specific antigen His_Phos_1 PF00300.17 CDI83467.1 - 0.00049 20.2 0.0 0.001 19.1 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.17 CDI83468.1 - 3e-06 27.4 0.2 0.00046 20.3 0.1 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.17 CDI83469.1 - 1.5e-08 34.9 0.0 2e-06 27.9 0.0 2.8 2 1 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) Seryl_tRNA_N PF02403.17 CDI83475.1 - 0.0088 16.0 14.2 0.0088 16.0 9.8 5.4 2 1 3 5 5 5 2 Seryl-tRNA synthetase N-terminal domain TMF_DNA_bd PF12329.3 CDI83475.1 - 0.02 14.6 3.4 0.02 14.6 2.4 6.9 4 2 2 7 7 7 0 TATA element modulatory factor 1 DNA binding NAAA-beta PF15508.1 CDI83475.1 - 0.44 10.9 10.9 0.43 10.9 0.4 3.4 3 1 0 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Reo_sigmaC PF04582.7 CDI83475.1 - 0.97 8.5 14.1 0.49 9.5 0.9 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein SprA-related PF12118.3 CDI83479.1 - 0.0019 17.5 31.9 0.0019 17.5 22.1 5.4 3 1 1 4 4 4 1 SprA-related family SR-25 PF10500.4 CDI83479.1 - 0.0022 17.5 13.5 0.0022 17.5 9.4 6.6 5 1 1 6 6 6 1 Nuclear RNA-splicing-associated protein SR-25 PF10500.4 CDI83480.1 - 1.9e-05 24.2 21.4 2.8e-05 23.7 14.8 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CAF-1_p150 PF11600.3 CDI83480.1 - 0.027 13.8 18.3 0.034 13.5 12.7 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SOBP PF15279.1 CDI83480.1 - 0.39 11.0 9.9 0.43 10.9 6.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein CDC73 PF05179.9 CDI83480.1 - 0.46 9.8 9.2 0.57 9.4 6.4 1.1 1 0 0 1 1 1 0 RNA pol II accessory factor, Cdc73 family NUC194 PF08163.7 CDI83480.1 - 1.5 7.5 4.8 1.9 7.2 3.3 1.1 1 0 0 1 1 1 0 NUC194 domain Dsh_C PF12316.3 CDI83480.1 - 1.8 8.6 14.4 2.2 8.3 10.0 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal eIF-3_zeta PF05091.7 CDI83480.1 - 2.1 6.8 11.1 2.4 6.6 7.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARP1 PF12569.3 CDI83480.1 - 2.5 6.7 9.1 2.6 6.7 6.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Hex_IIIa PF02455.11 CDI83480.1 - 3.3 6.2 11.6 3.7 6.1 8.1 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) LAP1C PF05609.7 CDI83480.1 - 3.6 6.1 13.1 4.3 5.8 9.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BTV_NS2 PF04514.7 CDI83480.1 - 6.3 5.5 11.0 7.5 5.3 7.6 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Macoilin PF09726.4 CDI83480.1 - 7.7 4.6 15.6 8.6 4.5 10.8 1.1 1 0 0 1 1 1 0 Transmembrane protein SGT1 PF07093.6 CDI83481.1 - 0.58 8.4 14.4 0.59 8.4 10.0 1.0 1 0 0 1 1 1 0 SGT1 protein Peptidase_U57 PF05582.7 CDI83481.1 - 1.7 7.5 7.2 1.6 7.5 5.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Plasmodium_Vir PF05795.6 CDI83481.1 - 2.6 7.1 6.0 2.7 7.0 4.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Cyto_heme_lyase PF01265.12 CDI83481.1 - 5.2 6.5 11.7 5.7 6.4 8.1 1.0 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase RR_TM4-6 PF06459.7 CDI83481.1 - 5.6 6.7 13.5 5.9 6.7 9.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YL1 PF05764.8 CDI83482.1 - 5.8e-12 45.7 39.3 5.8e-12 45.7 27.2 4.2 4 1 1 5 5 5 2 YL1 nuclear protein YL1_C PF08265.6 CDI83482.1 - 6.8e-07 28.7 0.0 1.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Kelch_4 PF13418.1 CDI83483.1 - 3.4e-14 52.3 12.3 0.00032 20.3 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI83483.1 - 5.4e-14 51.7 8.8 0.0024 17.7 0.0 6.5 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 CDI83483.1 - 3.2e-09 36.1 12.3 0.16 11.5 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 CDI83483.1 - 8.1e-07 28.9 10.5 1 9.6 0.3 6.1 5 1 1 6 6 6 3 Kelch motif Kelch_3 PF13415.1 CDI83483.1 - 2.6e-06 27.4 20.5 0.0025 17.9 0.0 7.3 8 0 0 8 8 8 3 Galactose oxidase, central domain Kelch_2 PF07646.10 CDI83483.1 - 0.0011 18.5 12.3 0.17 11.7 0.0 5.8 6 0 0 6 6 6 2 Kelch motif Pkinase PF00069.20 CDI83484.1 - 1.8e-56 191.2 0.0 1.8e-56 191.2 0.0 2.6 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83484.1 - 2.1e-33 115.4 0.7 3.2e-32 111.6 0.0 2.7 2 0 0 2 2 2 1 Protein tyrosine kinase Mlf1IP PF10248.4 CDI83485.1 - 0.38 10.3 3.8 1.6 8.2 0.1 2.2 2 0 0 2 2 2 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein MFS_1 PF07690.11 CDI83486.1 - 1.6e-31 109.3 28.4 2.8e-27 95.3 7.2 3.2 2 2 2 4 4 4 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDI83486.1 - 2.3e-07 29.7 13.1 2.2e-06 26.5 5.8 2.5 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.1 CDI83486.1 - 2e-05 23.1 11.3 0.00054 18.4 1.7 2.8 1 1 1 2 2 2 2 MFS/sugar transport protein ATG22 PF11700.3 CDI83486.1 - 0.00072 18.1 10.0 0.012 14.1 3.4 2.4 2 0 0 2 2 2 2 Vacuole effluxer Atg22 like MFS_1_like PF12832.2 CDI83486.1 - 0.0025 17.5 0.0 0.24 11.2 0.0 3.0 2 0 0 2 2 2 1 MFS_1 like family SET PF00856.23 CDI83488.1 - 6.6e-13 49.2 0.3 5.8e-09 36.4 0.0 2.8 3 0 0 3 3 3 2 SET domain SpoIIE PF07228.7 CDI83489.1 - 7e-08 32.4 0.2 8.3e-06 25.6 0.1 3.2 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) AP2 PF00847.15 CDI83490.1 - 5.6e-13 48.8 7.4 3.7e-10 39.7 0.1 3.1 3 0 0 3 3 3 2 AP2 domain ACDC PF14733.1 CDI83490.1 - 0.00023 21.1 0.0 0.00062 19.8 0.0 1.7 1 0 0 1 1 1 1 AP2-coincident C-terminal Methyltransf_16 PF10294.4 CDI83494.1 - 6.2e-07 29.0 0.0 0.0021 17.5 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase RRM_1 PF00076.17 CDI83496.1 - 3.2e-08 33.0 0.0 5.8e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI83496.1 - 9.9e-06 25.4 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI83496.1 - 0.038 13.8 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lactamase_B_2 PF12706.2 CDI83497.1 - 0.00041 19.9 0.0 0.73 9.3 0.0 3.0 3 1 0 3 3 3 2 Beta-lactamase superfamily domain AHSA1 PF08327.6 CDI83497.1 - 0.066 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein Pro_isomerase PF00160.16 CDI83500.1 - 2.1e-35 122.2 0.0 3.7e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SYF2 PF08231.7 CDI83500.1 - 0.00025 21.2 1.0 0.00025 21.2 0.7 3.5 2 2 1 3 3 3 1 SYF2 splicing factor DUF4479 PF14794.1 CDI83500.1 - 0.024 14.1 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) Ribosomal_L3 PF00297.17 CDI83501.1 - 2e-07 30.7 0.3 2e-07 30.7 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L3 Pex14_N PF04695.8 CDI83502.1 - 4.5e-05 23.5 3.0 7.2e-05 22.8 2.1 1.5 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region ubiquitin PF00240.18 CDI83502.1 - 7.5e-05 22.0 0.0 7.5e-05 22.0 0.0 2.3 2 1 0 2 2 1 1 Ubiquitin family Adenyl_cycl_N PF12633.2 CDI83502.1 - 0.00028 20.4 1.1 0.00042 19.9 0.8 1.3 1 0 0 1 1 1 1 Adenylate cyclase NT domain Spt20 PF12090.3 CDI83502.1 - 0.01 15.1 5.8 0.01 15.1 4.1 1.6 2 0 0 2 2 1 0 Spt20 family 7tm_1 PF00001.16 CDI83502.1 - 0.017 14.2 1.6 0.027 13.6 1.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF912 PF06024.7 CDI83502.1 - 0.017 15.1 1.8 0.03 14.3 1.3 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) FAM117 PF15388.1 CDI83502.1 - 0.017 14.3 5.8 0.025 13.8 4.0 1.2 1 0 0 1 1 1 0 Protein Family FAM117 Band_3_cyto PF07565.8 CDI83502.1 - 0.018 14.5 1.5 0.021 14.3 1.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Peptidase_S49_N PF08496.5 CDI83502.1 - 0.018 14.8 1.1 0.025 14.3 0.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FHIPEP PF00771.15 CDI83502.1 - 0.019 13.3 1.9 0.021 13.1 1.3 1.1 1 0 0 1 1 1 0 FHIPEP family eIF-3_zeta PF05091.7 CDI83502.1 - 0.037 12.6 6.8 0.042 12.4 4.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rad60-SLD PF11976.3 CDI83502.1 - 0.044 13.4 0.0 0.044 13.4 0.0 2.5 2 1 0 2 2 1 0 Ubiquitin-2 like Rad60 SUMO-like BRF1 PF07741.8 CDI83502.1 - 0.046 13.9 3.4 0.081 13.1 2.3 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RED_N PF07808.8 CDI83502.1 - 0.051 12.7 8.8 0.073 12.2 6.1 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region Serinc PF03348.10 CDI83502.1 - 0.052 12.2 2.2 0.068 11.8 1.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) OATP PF03137.15 CDI83502.1 - 0.068 11.2 6.6 0.091 10.7 4.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FimP PF09766.4 CDI83502.1 - 0.077 12.0 16.4 0.11 11.4 11.4 1.2 1 0 0 1 1 1 0 Fms-interacting protein Peroxin-13_N PF04088.8 CDI83502.1 - 0.077 12.9 0.9 0.12 12.3 0.6 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Folate_carrier PF01770.13 CDI83502.1 - 0.097 11.1 1.2 0.13 10.7 0.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier Het-C PF07217.6 CDI83502.1 - 0.098 10.8 4.4 0.13 10.4 3.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Ctr PF04145.10 CDI83502.1 - 0.13 12.3 1.0 0.19 11.7 0.7 1.4 1 0 0 1 1 1 0 Ctr copper transporter family Folliculin PF11704.3 CDI83502.1 - 0.14 11.7 7.3 4.4 6.8 0.0 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport SprA-related PF12118.3 CDI83502.1 - 0.16 11.2 20.1 0.28 10.4 13.9 1.4 1 0 0 1 1 1 0 SprA-related family AIF_C PF14721.1 CDI83502.1 - 0.19 11.9 3.2 0.31 11.3 2.3 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Glt_symporter PF03616.9 CDI83502.1 - 0.23 9.9 0.8 0.35 9.3 0.5 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Pex16 PF08610.5 CDI83502.1 - 0.27 10.1 5.0 0.39 9.6 3.5 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF2232 PF09991.4 CDI83502.1 - 0.43 9.5 3.1 0.65 8.9 2.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) CD20 PF04103.10 CDI83502.1 - 0.5 10.2 2.4 0.92 9.4 1.6 1.4 1 0 0 1 1 1 0 CD20-like family RR_TM4-6 PF06459.7 CDI83502.1 - 0.52 10.1 5.1 0.73 9.6 3.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4199 PF13858.1 CDI83502.1 - 0.69 9.8 6.5 1.2 9.0 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PAT1 PF09770.4 CDI83502.1 - 0.73 7.9 24.3 1 7.5 16.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 CDI83502.1 - 0.93 7.1 28.6 1.4 6.4 19.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2967 PF11179.3 CDI83502.1 - 1.3 8.4 9.2 1.8 7.9 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) FCP1_C PF09309.5 CDI83502.1 - 2.7 7.2 12.2 4 6.6 8.5 1.2 1 0 0 1 1 1 0 FCP1, C-terminal SseC PF04888.7 CDI83502.1 - 2.8 7.1 15.9 0.38 10.0 7.5 1.8 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family RIC3 PF15361.1 CDI83502.1 - 2.9 8.1 10.4 0.18 12.0 3.6 1.6 2 0 0 2 2 1 0 Resistance to inhibitors of cholinesterase homologue 3 Baculo_PP31 PF05311.6 CDI83502.1 - 2.9 7.0 9.2 4 6.6 6.4 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) BaxI_1 PF12811.2 CDI83502.1 - 9.8 5.2 6.6 17 4.4 4.6 1.4 1 0 0 1 1 1 0 Bax inhibitor 1 like Sec7 PF01369.15 CDI83506.1 - 9e-24 84.1 0.2 9e-24 84.1 0.1 2.8 2 1 0 2 2 2 1 Sec7 domain Pex14_N PF04695.8 CDI83506.1 - 0.0045 17.0 10.5 0.0045 17.0 7.3 11.2 10 2 2 12 12 12 3 Peroxisomal membrane anchor protein (Pex14p) conserved region SNF2_N PF00176.18 CDI83507.1 - 2.7e-58 197.1 0.1 4.5e-58 196.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain PHD PF00628.24 CDI83507.1 - 2.5e-20 71.9 86.4 1.1e-10 40.9 4.4 7.2 7 1 0 7 7 7 4 PHD-finger Helicase_C PF00271.26 CDI83507.1 - 1.9e-14 53.2 0.1 1.1e-13 50.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDI83507.1 - 7.3e-06 25.9 0.0 2.1e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CDI83507.1 - 1.8e-05 24.2 0.0 5.1e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase PHD_2 PF13831.1 CDI83507.1 - 0.00028 20.1 1.4 0.00028 20.1 1.0 6.8 7 0 0 7 7 7 1 PHD-finger Prok-RING_1 PF14446.1 CDI83507.1 - 0.0012 18.5 2.6 0.0012 18.5 1.8 7.0 8 0 0 8 8 8 3 Prokaryotic RING finger family 1 C1_1 PF00130.17 CDI83507.1 - 0.0012 18.5 1.4 0.0012 18.5 1.0 7.6 6 1 1 7 7 7 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.1 CDI83507.1 - 0.0024 17.1 1.1 0.0024 17.1 0.8 7.0 6 2 2 8 8 8 2 PHD/FYVE-zinc-finger like domain AAA_14 PF13173.1 CDI83507.1 - 0.0025 17.6 0.0 0.009 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain SET PF00856.23 CDI83509.1 - 2.4e-12 47.4 1.1 2.6e-10 40.8 0.0 3.9 3 1 0 3 3 3 1 SET domain RapA_C PF12137.3 CDI83509.1 - 0.098 11.4 7.3 0.17 10.6 5.0 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal AAA_13 PF13166.1 CDI83509.1 - 0.35 9.2 6.6 0.63 8.4 4.6 1.3 1 0 0 1 1 1 0 AAA domain Arm PF00514.18 CDI83511.1 - 2.7e-08 33.3 7.9 0.079 12.8 0.0 6.1 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 CDI83511.1 - 8.1e-08 32.4 1.9 0.00032 20.9 0.0 4.2 3 2 0 3 3 3 1 HEAT repeats V-ATPase_H_C PF11698.3 CDI83511.1 - 2.4e-05 24.2 0.0 0.00011 22.0 0.0 2.1 2 0 0 2 2 2 1 V-ATPase subunit H HEAT PF02985.17 CDI83511.1 - 0.0047 16.8 5.8 10 6.4 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat SPO22 PF08631.5 CDI83511.1 - 0.012 14.6 0.0 0.86 8.6 0.0 2.3 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like HEAT_EZ PF13513.1 CDI83511.1 - 0.12 12.9 1.8 3.4 8.2 0.0 4.2 6 0 0 6 6 6 0 HEAT-like repeat Tim17 PF02466.14 CDI83513.1 - 4.5e-30 104.3 4.0 6.5e-30 103.7 2.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Ribosomal_L38e PF01781.13 CDI83514.1 - 0.1 12.3 0.4 3.5 7.4 0.0 2.3 2 0 0 2 2 2 0 Ribosomal L38e protein family DHO_dh PF01180.16 CDI83517.1 - 1.5e-101 339.2 0.0 1.8e-101 339.0 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 CDI83517.1 - 0.00031 19.6 0.5 0.038 12.8 0.3 2.4 2 1 0 2 2 2 2 FMN-dependent dehydrogenase PcrB PF01884.12 CDI83517.1 - 0.012 14.8 0.1 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 PcrB family UvrD_C PF13361.1 CDI83518.1 - 8.1e-40 137.3 0.2 2.3e-19 70.0 0.0 3.9 4 0 0 4 4 4 3 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 CDI83518.1 - 2.4e-35 122.3 0.1 1.5e-32 113.1 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.1 CDI83518.1 - 1.7e-07 30.8 1.8 3.7e-07 29.8 0.1 2.6 3 0 0 3 3 3 1 Part of AAA domain UvrD_C_2 PF13538.1 CDI83518.1 - 2.5e-07 30.7 5.6 0.00028 20.9 0.0 3.1 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain AAA_12 PF13087.1 CDI83518.1 - 0.016 14.6 0.0 0.016 14.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain Ycf1 PF05758.7 CDI83518.1 - 0.26 8.9 7.1 0.37 8.4 4.9 1.1 1 0 0 1 1 1 0 Ycf1 RNase_H2_suC PF08615.6 CDI83519.1 - 0.004 17.0 1.4 0.02 14.7 1.0 2.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) GrpE PF01025.14 CDI83519.1 - 0.022 14.3 0.5 0.022 14.3 0.3 6.3 3 1 1 5 5 5 0 GrpE DUF3138 PF11336.3 CDI83519.1 - 9.6 4.2 13.8 0.15 10.2 1.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) PRKCSH PF07915.8 CDI83520.1 - 2.1e-11 44.4 0.0 7.5e-05 23.4 0.0 3.2 2 1 0 2 2 2 2 Glucosidase II beta subunit-like protein YccV-like PF08755.6 CDI83520.1 - 4.5e-11 42.5 0.0 1.1e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like TPR_12 PF13424.1 CDI83521.1 - 5.8e-08 32.5 15.3 1.8e-06 27.7 1.7 3.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDI83521.1 - 0.00029 20.3 5.0 0.79 9.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDI83521.1 - 0.00075 19.1 6.7 2.7 7.9 0.1 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDI83521.1 - 0.0041 16.8 9.5 0.082 12.7 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDI83521.1 - 0.0047 16.5 12.4 0.15 11.7 1.8 3.2 3 1 0 3 3 3 2 TPR repeat Apc3 PF12895.2 CDI83521.1 - 0.015 15.4 5.0 0.028 14.5 1.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 CDI83521.1 - 0.027 14.6 0.7 9.4 6.7 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP-cone PF03477.11 CDI83521.1 - 0.044 14.2 1.4 0.2 12.1 0.0 2.6 3 1 0 3 3 3 0 ATP cone domain iPGM_N PF06415.8 CDI83521.1 - 0.07 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) TPR_2 PF07719.12 CDI83521.1 - 0.41 10.6 16.1 3.9 7.6 0.4 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 CDI83521.1 - 4.5 7.6 9.4 0.93 9.8 0.1 3.4 4 1 0 4 4 4 0 Tetratricopeptide repeat Apc5 PF12862.2 CDI83521.1 - 7.5 6.4 9.3 2 8.3 0.1 2.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 PCI PF01399.22 CDI83522.1 - 5.9e-05 23.3 0.3 5.9e-05 23.3 0.2 3.0 3 0 0 3 3 3 1 PCI domain Mucin PF01456.12 CDI83524.1 - 5.8 6.6 24.6 2.2 8.0 12.1 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein Cullin PF00888.17 CDI83529.1 - 1.4e-10 40.3 0.0 3.2e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 CDI83529.1 - 1.4e-10 40.7 0.6 6.5e-10 38.7 0.4 2.0 1 1 0 1 1 1 1 Cullin protein neddylation domain SpoIIE PF07228.7 CDI83529.1 - 0.028 14.1 0.0 0.074 12.7 0.0 1.7 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) MORN PF02493.15 CDI83535.1 - 8.8e-52 169.8 52.7 5.6e-07 28.9 1.3 10.2 10 0 0 10 10 10 10 MORN repeat Ras PF00071.17 CDI83536.1 - 4.7e-59 198.3 0.0 5.9e-59 198.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI83536.1 - 1.9e-17 63.8 0.0 3.3e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDI83536.1 - 1.7e-12 46.9 0.0 2.1e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDI83536.1 - 6.6e-07 28.7 0.0 8.1e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 CDI83536.1 - 0.0013 18.6 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDI83536.1 - 0.0093 15.4 0.0 0.03 13.7 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Pkinase PF00069.20 CDI83537.1 - 3.7e-38 131.1 0.0 2.4e-27 95.7 0.0 4.2 3 2 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83537.1 - 4.9e-35 120.8 0.0 4.5e-14 52.1 0.0 5.3 2 2 1 3 3 3 3 Protein tyrosine kinase AAA PF00004.24 CDI83538.1 - 1.2e-16 61.1 0.0 2e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 CDI83538.1 - 1.9e-12 47.1 0.0 6.9e-09 35.5 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase III, delta subunit AAA_22 PF13401.1 CDI83538.1 - 9.1e-08 32.3 0.1 2e-06 27.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDI83538.1 - 3.8e-06 26.9 1.9 3.5e-05 23.8 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 CDI83538.1 - 4.3e-06 26.3 1.3 2.4e-05 24.0 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 CDI83538.1 - 5e-06 26.4 0.0 8.9e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 CDI83538.1 - 5.9e-06 25.9 0.1 4.3e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 CDI83538.1 - 1.2e-05 25.0 0.0 2.6e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.10 CDI83538.1 - 5.3e-05 22.0 0.0 7.7e-05 21.5 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 CDI83538.1 - 0.0024 16.9 0.0 0.0051 15.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Rep_fac_C PF08542.6 CDI83538.1 - 0.0024 17.8 0.0 0.16 11.9 0.0 2.5 1 1 1 2 2 2 1 Replication factor C C-terminal domain AAA_5 PF07728.9 CDI83538.1 - 0.0029 17.3 0.0 0.012 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DEAD PF00270.24 CDI83538.1 - 0.0033 16.9 0.1 0.15 11.5 0.0 2.4 1 1 0 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.4 CDI83538.1 - 0.0098 14.9 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.2 CDI83538.1 - 0.016 14.6 0.1 4.6 6.5 0.0 2.2 1 1 1 2 2 2 0 AAA-like domain DUF815 PF05673.8 CDI83538.1 - 0.02 13.8 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.1 CDI83538.1 - 0.02 14.7 0.1 0.04 13.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 CDI83538.1 - 0.029 14.2 0.0 0.084 12.6 0.0 1.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.16 CDI83538.1 - 0.041 13.0 0.1 0.27 10.3 0.0 2.1 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 CDI83538.1 - 0.056 12.8 0.1 0.67 9.3 0.0 2.1 1 1 0 2 2 2 0 AAA domain PhoH PF02562.11 CDI83538.1 - 0.077 12.2 0.0 2.4 7.3 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein FtsK_SpoIIIE PF01580.13 CDI83538.1 - 0.11 11.9 0.1 0.36 10.2 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Spt4 PF06093.8 CDI83538.1 - 0.23 11.3 1.5 0.48 10.3 1.0 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger ThiF PF00899.16 CDI83540.1 - 0.011 15.6 0.4 0.017 14.9 0.3 1.2 1 0 0 1 1 1 0 ThiF family DUF4610 PF15384.1 CDI83540.1 - 0.021 14.3 3.4 2.3 7.7 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4610) DUF4238 PF14022.1 CDI83540.1 - 0.042 13.1 1.4 0.052 12.8 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) Cob_adeno_trans PF01923.13 CDI83540.1 - 0.058 13.1 5.3 0.052 13.3 2.7 1.6 1 1 0 1 1 1 0 Cobalamin adenosyltransferase DUF3987 PF13148.1 CDI83540.1 - 0.061 11.8 7.2 0.017 13.6 2.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) CDC37_N PF03234.9 CDI83540.1 - 0.067 13.5 3.8 0.096 12.9 2.6 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Tautomerase_2 PF14552.1 CDI83540.1 - 0.094 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Tautomerase enzyme DUF3584 PF12128.3 CDI83540.1 - 0.11 9.8 10.9 0.15 9.3 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.7 CDI83540.1 - 0.11 12.2 3.2 0.2 11.4 2.2 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tho2 PF11262.3 CDI83540.1 - 0.13 11.2 1.4 0.19 10.7 1.0 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF342 PF03961.8 CDI83540.1 - 0.2 9.9 6.3 0.26 9.6 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF2564 PF10819.3 CDI83540.1 - 0.29 11.2 6.3 0.51 10.4 3.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) AAA_13 PF13166.1 CDI83540.1 - 0.34 9.3 8.2 0.24 9.8 4.9 1.2 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.7 CDI83540.1 - 0.49 10.2 4.3 0.69 9.7 2.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.10 CDI83540.1 - 0.53 9.4 6.7 0.71 9.0 4.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FemAB PF02388.11 CDI83540.1 - 0.63 8.6 6.7 1.1 7.9 4.7 1.3 1 0 0 1 1 1 0 FemAB family DUF948 PF06103.6 CDI83540.1 - 0.68 9.8 2.6 3.1 7.7 0.2 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TMPIT PF07851.8 CDI83540.1 - 0.9 8.5 4.4 1.1 8.3 3.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein Macoilin PF09726.4 CDI83540.1 - 0.91 7.7 11.5 1.1 7.4 8.0 1.0 1 0 0 1 1 1 0 Transmembrane protein Fib_alpha PF08702.5 CDI83540.1 - 1.2 9.2 5.6 1.4 9.0 3.2 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_23 PF13476.1 CDI83540.1 - 2 8.7 7.0 3.2 8.0 4.8 1.4 1 0 0 1 1 1 0 AAA domain FUSC PF04632.7 CDI83540.1 - 2.2 6.6 6.9 2.8 6.2 4.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ACCA PF03255.9 CDI83540.1 - 2.2 7.8 5.3 6.3 6.3 1.1 2.2 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit IncA PF04156.9 CDI83540.1 - 4.5 6.8 18.7 12 5.3 12.9 1.6 1 1 0 1 1 1 0 IncA protein DUF4407 PF14362.1 CDI83540.1 - 4.5 6.1 11.8 5.8 5.7 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cation_efflux PF01545.16 CDI83541.1 - 1.8e-57 194.6 10.2 2.3e-57 194.2 7.1 1.1 1 0 0 1 1 1 1 Cation efflux family SR-25 PF10500.4 CDI83541.1 - 3.4e-05 23.4 0.6 3.4e-05 23.4 0.4 3.0 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF4407 PF14362.1 CDI83541.1 - 4.9 6.0 10.4 0.091 11.7 2.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DNA_pol_A_exo1 PF01612.15 CDI83544.1 - 2.4e-25 89.0 0.0 5.7e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 3'-5' exonuclease RNase_T PF00929.19 CDI83545.1 - 8.2e-29 100.9 0.0 9.4e-29 100.8 0.0 1.0 1 0 0 1 1 1 1 Exonuclease eIF2A PF08662.6 CDI83546.1 - 2.3e-38 131.8 0.0 2e-37 128.7 0.0 2.4 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A TRAM_LAG1_CLN8 PF03798.11 CDI83547.1 - 0.00012 21.7 7.4 0.021 14.3 1.7 2.2 1 1 1 2 2 2 2 TLC domain Arf PF00025.16 CDI83549.1 - 2e-54 183.4 0.0 2.3e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 CDI83549.1 - 1.6e-11 44.7 0.0 2.1e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 CDI83549.1 - 1.2e-10 40.9 0.0 1.5e-10 40.5 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 CDI83549.1 - 7.1e-10 38.1 0.1 2.5e-07 29.7 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 CDI83549.1 - 9.5e-10 38.0 0.0 1.1e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 CDI83549.1 - 5.2e-07 29.6 0.0 6.9e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDI83549.1 - 6e-06 25.5 0.0 7.5e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDI83549.1 - 2.3e-05 23.8 0.1 0.0011 18.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain CENP-M PF11111.3 CDI83549.1 - 0.011 15.0 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 Centromere protein M (CENP-M) cobW PF02492.14 CDI83549.1 - 0.033 13.6 0.0 3 7.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 CDI83549.1 - 0.04 13.3 0.0 0.1 12.0 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 CDI83549.1 - 0.054 13.4 0.1 0.33 10.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.13 CDI83549.1 - 0.09 12.0 0.0 0.71 9.1 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B FAST_1 PF06743.10 CDI83551.1 - 0.00089 18.9 2.2 1.3 8.7 0.0 4.6 3 1 2 5 5 5 3 FAST kinase-like protein, subdomain 1 CK_II_beta PF01214.13 CDI83553.1 - 5.7e-43 146.5 0.1 1.8e-42 144.9 0.0 1.7 2 0 0 2 2 2 1 Casein kinase II regulatory subunit Nucleoplasmin PF03066.10 CDI83553.1 - 0.0083 15.6 3.3 0.014 14.8 2.3 1.4 1 0 0 1 1 1 1 Nucleoplasmin AF1Q PF15017.1 CDI83553.1 - 0.029 14.2 5.7 0.056 13.3 3.9 1.4 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator RRP7 PF12923.2 CDI83553.1 - 0.073 13.0 1.3 0.12 12.3 0.9 1.3 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) Myc_N PF01056.13 CDI83553.1 - 0.12 11.5 5.1 0.18 10.9 3.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Radial_spoke PF04712.7 CDI83553.1 - 0.16 10.6 4.4 0.19 10.4 3.1 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein VID27 PF08553.5 CDI83553.1 - 2.1 6.4 5.0 2.5 6.2 3.5 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein CENP-B_dimeris PF09026.5 CDI83553.1 - 2.3 8.5 11.4 1.8 8.8 6.3 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Daxx PF03344.10 CDI83553.1 - 2.4 6.5 6.0 2.6 6.4 4.2 1.1 1 0 0 1 1 1 0 Daxx Family AAA_33 PF13671.1 CDI83555.1 - 1e-24 87.0 0.1 2.6e-24 85.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain SPRY PF00622.23 CDI83555.1 - 1.7e-21 76.5 0.2 4.5e-21 75.2 0.1 1.8 1 0 0 1 1 1 1 SPRY domain AAA_18 PF13238.1 CDI83555.1 - 0.046 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDI83555.1 - 0.053 12.6 0.7 0.14 11.1 0.0 2.0 2 1 0 2 2 2 0 Zeta toxin TFIIA PF03153.8 CDI83555.1 - 0.15 11.9 12.1 0.28 11.0 8.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_M28 PF04389.12 CDI83557.1 - 1.1e-21 77.4 0.0 1.1e-21 77.4 0.0 2.9 3 0 0 3 3 2 1 Peptidase family M28 Ctr PF04145.10 CDI83557.1 - 0.0029 17.6 4.9 8.1 6.4 0.0 4.2 3 0 0 3 3 3 1 Ctr copper transporter family UPF0560 PF10577.4 CDI83557.1 - 0.048 11.9 19.2 0.0044 15.3 6.8 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 DUF2052 PF09747.4 CDI83557.1 - 0.18 11.7 17.0 0.58 10.0 6.0 2.8 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4557 PF15101.1 CDI83557.1 - 0.4 10.5 23.3 0.039 13.8 8.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Suf PF05843.9 CDI83557.1 - 0.78 9.4 13.7 0.72 9.5 5.9 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Folate_carrier PF01770.13 CDI83557.1 - 2.5 6.5 7.4 0.35 9.3 1.8 2.0 2 0 0 2 2 2 0 Reduced folate carrier Spore_coat_CotO PF14153.1 CDI83557.1 - 3.5 7.0 20.2 0.55 9.6 7.6 2.5 2 0 0 2 2 2 0 Spore coat protein CotO Gti1_Pac2 PF09729.4 CDI83557.1 - 4.8 7.0 7.8 4.2 7.2 2.8 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family Band_3_cyto PF07565.8 CDI83557.1 - 6.5 6.1 13.2 2.2 7.7 4.3 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4647 PF15504.1 CDI83557.1 - 8.8 5.0 17.7 0.066 12.0 4.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) FAM176 PF14851.1 CDI83557.1 - 8.9 5.9 11.8 7.6 6.2 3.0 3.1 3 0 0 3 3 3 0 FAM176 family EIIBC-GUT_N PF03612.9 CDI83557.1 - 9.3 5.8 9.2 2.9 7.4 2.8 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Metallophos PF00149.23 CDI83558.1 - 9.3e-35 119.8 0.1 1.3e-34 119.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_11 PF13414.1 CDI83558.1 - 1e-18 66.6 4.7 1.6e-14 53.2 0.2 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 CDI83558.1 - 2.4e-14 52.0 2.5 0.00063 19.4 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat PPP5 PF08321.7 CDI83558.1 - 2.6e-14 52.9 0.0 6.9e-14 51.6 0.0 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.23 CDI83558.1 - 2.7e-11 42.5 2.2 0.011 15.3 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 CDI83558.1 - 0.0014 19.0 0.2 4.1 8.3 0.0 3.8 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI83558.1 - 0.0022 18.0 0.1 0.009 16.1 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDI83558.1 - 0.0032 17.3 1.3 0.05 13.5 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDI83558.1 - 0.0038 17.0 0.1 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDI83558.1 - 0.058 14.0 3.3 4.8 7.9 0.2 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat U5_2-snRNA_bdg PF10597.4 CDI83559.1 - 5.8e-05 22.7 0.0 0.23 11.0 0.0 3.0 1 1 2 3 3 3 3 U5-snRNA binding site 2 of PrP8 GTP_EFTU PF00009.22 CDI83560.1 - 8.4e-28 97.0 0.0 2.9e-27 95.3 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 CDI83560.1 - 3.4e-17 62.2 0.3 8.6e-17 60.9 0.2 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.1 CDI83560.1 - 5.6e-10 38.7 0.5 1.3e-09 37.5 0.3 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 CDI83560.1 - 2.3e-05 24.3 0.0 7.7e-05 22.6 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 CDI83560.1 - 0.0033 17.5 1.4 0.0033 17.5 0.9 2.6 3 0 0 3 3 3 1 Elongation factor Tu domain 2 ATP_bind_1 PF03029.12 CDI83560.1 - 0.013 15.0 0.0 0.035 13.6 0.0 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 CDI83560.1 - 0.046 13.8 0.0 0.046 13.8 0.0 2.8 3 0 0 3 3 3 0 AAA domain Neur_chan_memb PF02932.11 CDI83561.1 - 0.35 10.7 17.0 3.2 7.5 6.2 3.0 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RNA_pol_Rpc4 PF05132.9 CDI83561.1 - 1.6 8.7 27.1 0.07 13.1 1.8 4.3 5 0 0 5 5 5 0 RNA polymerase III RPC4 OATP PF03137.15 CDI83561.1 - 2.3 6.1 8.7 2.7 5.9 0.8 2.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Plasmodium_Vir PF05795.6 CDI83561.1 - 2.5 7.2 5.1 14 4.7 0.1 2.4 2 1 0 2 2 2 0 Plasmodium vivax Vir protein DUF966 PF06136.8 CDI83561.1 - 2.5 7.4 17.9 1.3 8.3 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF966) Spt20 PF12090.3 CDI83561.1 - 3.6 6.8 28.5 0.9 8.8 2.8 4.2 4 0 0 4 4 4 0 Spt20 family RXT2_N PF08595.6 CDI83562.1 - 0.34 10.7 10.0 0.92 9.2 6.9 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal UBN_AB PF14075.1 CDI83562.1 - 0.51 9.9 2.2 0.92 9.1 1.5 1.3 1 0 0 1 1 1 0 Ubinuclein conserved middle domain CENP-B_dimeris PF09026.5 CDI83562.1 - 2.2 8.5 18.7 0.79 9.9 10.1 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PBP1_TM PF14812.1 CDI83562.1 - 4.1 7.7 12.2 9.4 6.6 8.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TIP49 PF06068.8 CDI83564.1 - 2.9e-94 316.0 0.1 3.4e-94 315.8 0.1 1.0 1 0 0 1 1 1 1 TIP49 C-terminus Pkinase PF00069.20 CDI83567.1 - 7.3 5.6 16.6 0.39 9.8 5.5 2.9 2 1 0 2 2 2 0 Protein kinase domain DOR PF14839.1 CDI83568.1 - 0.087 12.5 15.3 0.11 12.2 10.6 1.2 1 0 0 1 1 1 0 DOR family DDHD PF02862.12 CDI83568.1 - 0.53 10.0 6.9 0.59 9.9 4.8 1.1 1 0 0 1 1 1 0 DDHD domain DUF4355 PF14265.1 CDI83568.1 - 0.63 10.0 12.9 0.78 9.6 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) TIP41 PF04176.8 CDI83568.1 - 1.4 8.1 4.9 1.8 7.7 3.4 1.1 1 0 0 1 1 1 0 TIP41-like family MTBP_C PF14920.1 CDI83568.1 - 2.7 7.4 11.6 3.2 7.1 8.0 1.1 1 0 0 1 1 1 0 MDM2-binding Med15 PF09606.5 CDI83568.1 - 5.2 5.1 30.4 5.7 5.0 21.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SprA-related PF12118.3 CDI83568.1 - 6.4 6.0 26.0 7.6 5.7 18.0 1.1 1 0 0 1 1 1 0 SprA-related family PAT1 PF09770.4 CDI83568.1 - 7.6 4.6 25.3 8.1 4.5 17.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.12 CDI83568.1 - 9.5 4.9 7.1 10 4.8 4.9 1.1 1 0 0 1 1 1 0 Presenilin WD40 PF00400.27 CDI83570.1 - 0.001 18.8 0.0 0.0074 16.1 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF972 PF06156.8 CDI83571.1 - 0.027 14.7 25.9 0.047 14.0 3.6 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF972) Macoilin PF09726.4 CDI83571.1 - 0.066 11.4 29.3 0.11 10.8 20.3 1.2 1 0 0 1 1 1 0 Transmembrane protein Bacillus_HBL PF05791.6 CDI83571.1 - 8.5 5.6 9.3 0.31 10.3 0.4 2.3 1 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Ribosomal_L23 PF00276.15 CDI83573.1 - 1.3e-11 44.3 0.0 2.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 Peptidase_C8 PF03569.8 CDI83573.1 - 0.09 12.0 0.2 0.93 8.7 0.0 2.3 3 0 0 3 3 3 0 Peptidase family C8 Peptidase_C97 PF05903.9 CDI83575.1 - 8.2e-21 74.3 0.0 1.4e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain ADH_zinc_N PF00107.21 CDI83576.1 - 2.7e-07 30.1 1.3 3.3e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDI83576.1 - 0.00063 19.4 0.1 0.0011 18.7 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Phostensin_N PF13916.1 CDI83576.1 - 0.021 14.7 6.1 0.036 14.0 4.2 1.3 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Lyase_1 PF00206.15 CDI83577.1 - 9.6e-42 143.2 0.0 1.3e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.6 CDI83577.1 - 0.00014 21.6 0.0 0.00052 19.8 0.0 1.9 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal Ribosomal_S7e PF01251.13 CDI83578.1 - 1.7e-38 131.9 0.1 1.6e-33 115.7 0.0 2.0 1 1 1 2 2 2 2 Ribosomal protein S7e DUF4208 PF13907.1 CDI83578.1 - 0.017 15.2 0.2 0.046 13.9 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4208) He_PIG PF05345.7 CDI83580.1 - 0.0044 17.0 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Putative Ig domain Dus PF01207.12 CDI83581.1 - 7.9e-53 179.3 0.0 1.4e-52 178.4 0.0 1.4 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) IP_trans PF02121.13 CDI83582.1 - 3.4e-40 137.8 0.0 1e-32 113.2 0.0 2.2 2 0 0 2 2 2 2 Phosphatidylinositol transfer protein Oxysterol_BP PF01237.13 CDI83582.1 - 1.6e-13 49.8 0.0 2.7e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.24 CDI83582.1 - 8.7e-10 38.7 0.0 1.5e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 CDI83582.1 - 3.8e-07 30.3 0.0 0.00082 19.5 0.0 2.7 1 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.1 CDI83582.1 - 0.082 13.0 0.3 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain Aminotran_1_2 PF00155.16 CDI83583.1 - 3.1e-28 98.7 0.4 7.1e-28 97.5 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II CPSase_sm_chain PF00988.17 CDI83586.1 - 1.5e-31 108.6 0.0 4.8e-31 106.9 0.0 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 CDI83586.1 - 9.2e-22 77.4 0.0 2e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CDI83586.1 - 9.8e-06 25.1 0.0 9.8e-06 25.1 0.0 2.4 2 1 1 3 3 3 1 Peptidase C26 DJ-1_PfpI PF01965.19 CDI83586.1 - 0.013 14.9 9.0 0.038 13.4 6.3 1.8 1 0 0 1 1 1 0 DJ-1/PfpI family MutS_III PF05192.13 CDI83586.1 - 0.035 13.8 0.1 0.058 13.1 0.1 1.4 1 0 0 1 1 1 0 MutS domain III Pkinase PF00069.20 CDI83588.1 - 1.8e-07 30.6 0.0 4.4e-06 26.0 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83588.1 - 0.0014 17.7 0.0 0.0038 16.3 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.17 CDI83588.1 - 0.06 13.4 0.6 2.4 8.4 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat Tmemb_cc2 PF10267.4 CDI83588.1 - 0.75 8.3 3.3 0.45 9.0 0.4 1.9 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein zf-HC5HC2H_2 PF13832.1 CDI83589.1 - 7e-13 48.5 9.8 7e-13 48.5 6.8 2.8 2 2 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 CDI83589.1 - 1.5e-12 47.5 9.9 1.5e-12 47.5 6.8 2.8 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD PF00628.24 CDI83589.1 - 1.6e-10 40.5 6.7 1.6e-10 40.5 4.6 3.6 4 0 0 4 4 4 2 PHD-finger PHD_2 PF13831.1 CDI83589.1 - 9.7e-10 37.5 2.3 9.7e-10 37.5 1.6 3.5 4 0 0 4 4 4 2 PHD-finger Prok-RING_1 PF14446.1 CDI83589.1 - 3.8e-05 23.3 2.2 3.8e-05 23.3 1.5 3.4 5 0 0 5 5 5 1 Prokaryotic RING finger family 1 zf-PHD-like PF15446.1 CDI83589.1 - 0.0048 16.2 1.3 0.0048 16.2 0.9 2.8 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain C1_1 PF00130.17 CDI83589.1 - 0.022 14.4 0.7 0.022 14.4 0.5 3.7 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Utp21 PF04192.7 CDI83590.1 - 9.1e-27 93.6 6.1 9.1e-27 93.6 4.2 2.2 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 CDI83590.1 - 9.5e-14 50.6 2.4 0.031 14.1 0.2 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat Ribosomal_60s PF00428.14 CDI83590.1 - 0.00015 22.1 32.4 0.0012 19.1 5.2 6.5 6 0 0 6 6 6 2 60s Acidic ribosomal protein Pex14_N PF04695.8 CDI83590.1 - 0.012 15.6 2.0 0.012 15.6 1.4 3.2 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RAB3GAP2_N PF14655.1 CDI83590.1 - 0.013 14.5 1.3 0.038 13.0 0.9 1.8 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Gti1_Pac2 PF09729.4 CDI83590.1 - 0.025 14.4 5.1 6 6.7 0.2 3.4 3 0 0 3 3 3 0 Gti1/Pac2 family DUF3312 PF11768.3 CDI83590.1 - 0.034 12.3 0.0 0.056 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) HlyD_2 PF12700.2 CDI83590.1 - 0.9 8.6 12.8 0.064 12.4 0.4 3.1 3 0 0 3 3 3 0 HlyD family secretion protein DUF2937 PF11157.3 CDI83593.1 - 2.7 7.2 12.6 11 5.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) CS PF04969.11 CDI83594.1 - 6.3e-17 61.8 0.0 1.1e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 CS domain Nudc_N PF14050.1 CDI83594.1 - 5.3e-16 58.3 1.2 1.4e-15 56.9 0.9 1.8 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. BAF1_ABF1 PF04684.8 CDI83594.1 - 0.21 10.3 9.0 0.038 12.8 3.7 1.6 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Plasmodium_Vir PF05795.6 CDI83594.1 - 0.72 8.9 2.6 1.3 8.1 1.8 1.5 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Lsr2 PF11774.3 CDI83594.1 - 0.78 9.6 9.4 0.47 10.4 4.7 2.0 2 0 0 2 2 2 0 Lsr2 RAB3GAP2_N PF14655.1 CDI83594.1 - 1.2 8.0 5.2 2 7.3 3.6 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Hid1 PF12722.2 CDI83594.1 - 4.9 4.6 11.8 7.7 4.0 8.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Activator_LAG-3 PF11498.3 CDI83594.1 - 7.6 5.1 25.0 15 4.1 13.7 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 UPF0231 PF06062.6 CDI83595.1 - 0.3 10.9 4.1 0.35 10.7 1.0 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) UPF0016 PF01169.14 CDI83596.1 - 8.3e-21 73.9 14.3 3.5e-07 30.2 0.8 3.3 3 0 0 3 3 3 3 Uncharacterized protein family UPF0016 DUF2076 PF09849.4 CDI83596.1 - 0.0016 18.5 0.1 2 8.4 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2076) DUF4131 PF13567.1 CDI83596.1 - 6 6.2 11.1 0.35 10.2 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) RNase_H2_suC PF08615.6 CDI83597.1 - 3.7e-11 43.0 0.0 1.1e-10 41.5 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Oxidored-like PF09791.4 CDI83598.1 - 0.013 14.8 0.1 0.02 14.3 0.1 1.4 1 0 0 1 1 1 0 Oxidoreductase-like protein, N-terminal Peptidase_S24 PF00717.18 CDI83599.1 - 3.6e-08 32.9 0.1 5.9e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like DUF3099 PF11298.3 CDI83599.1 - 2.5 7.9 5.7 1.1 9.0 0.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3099) Daxx PF03344.10 CDI83600.1 - 0.045 12.2 19.9 0.057 11.9 13.8 1.1 1 0 0 1 1 1 0 Daxx Family MOR2-PAG1_N PF14222.1 CDI83600.1 - 0.09 11.4 0.5 0.13 10.9 0.3 1.2 1 0 0 1 1 1 0 Cell morphogenesis N-terminal Peptidase_S64 PF08192.6 CDI83600.1 - 0.18 10.0 5.0 0.22 9.8 3.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.2 CDI83600.1 - 1.5 6.4 10.3 1.8 6.1 7.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.7 CDI83600.1 - 3.7 5.3 28.2 4.8 4.9 19.5 1.1 1 0 0 1 1 1 0 Nop14-like family MIP-T3 PF10243.4 CDI83600.1 - 10 4.4 29.0 14 4.0 20.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Cyclin_C PF02984.14 CDI83603.1 - 0.0018 18.1 0.2 0.0018 18.1 0.1 3.2 3 0 0 3 3 3 1 Cyclin, C-terminal domain HEAT PF02985.17 CDI83604.1 - 6.7e-05 22.6 24.6 2 8.6 0.1 8.3 7 0 0 7 7 7 4 HEAT repeat DUF755 PF05501.6 CDI83605.1 - 0.013 15.5 20.4 0.013 15.5 14.1 5.8 6 0 0 6 6 6 0 Domain of unknown function (DUF755) CTP_transf_1 PF01148.15 CDI83606.1 - 2.6e-29 102.6 5.5 3.4e-29 102.2 3.8 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Kelch_3 PF13415.1 CDI83607.1 - 1.1e-09 38.1 3.0 8.5e-05 22.6 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.1 CDI83607.1 - 9.8e-07 28.4 0.1 0.57 9.9 0.0 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI83607.1 - 0.0006 19.7 0.2 0.063 13.2 0.3 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.10 CDI83607.1 - 0.00079 19.0 4.1 0.04 13.6 0.8 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.20 CDI83607.1 - 0.019 14.5 0.0 0.37 10.3 0.0 2.7 2 0 0 2 2 2 0 Kelch motif DUF2464 PF10240.4 CDI83607.1 - 1.6 7.9 9.7 0.81 8.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2464) Pex14_N PF04695.8 CDI83607.1 - 1.7 8.6 7.6 2.1 8.3 0.8 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Kelch_5 PF13854.1 CDI83608.1 - 6.6e-24 83.4 0.1 2.3e-07 30.6 0.0 5.0 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 CDI83608.1 - 6.6e-21 73.8 7.8 4.8e-10 39.0 0.0 5.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.1 CDI83608.1 - 4.5e-20 71.2 18.4 1.2e-08 34.8 0.0 6.6 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.10 CDI83608.1 - 1.4e-18 65.8 2.9 4.6e-06 26.1 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 CDI83608.1 - 1.7e-18 65.9 0.0 3.6e-05 23.2 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 CDI83608.1 - 2.7e-15 55.7 1.0 0.0011 19.0 0.0 4.8 5 0 0 5 5 5 3 Kelch motif PHD_3 PF13922.1 CDI83608.1 - 5.9 7.2 11.9 5 7.4 2.9 2.9 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx NAD_synthase PF02540.12 CDI83609.1 - 7.7e-26 90.4 0.0 3.1e-14 52.4 0.0 3.2 3 0 0 3 3 3 3 NAD synthase CN_hydrolase PF00795.17 CDI83609.1 - 4e-20 71.9 0.1 6e-19 68.1 0.0 2.6 2 1 0 2 2 2 1 Carbon-nitrogen hydrolase Kelch_1 PF01344.20 CDI83610.1 - 1.8e-62 206.6 0.0 7.5e-12 44.6 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 CDI83610.1 - 1.4e-48 161.1 0.1 2.1e-09 37.1 0.0 6.4 2 2 4 6 6 6 6 Kelch motif Kelch_4 PF13418.1 CDI83610.1 - 2.7e-35 119.8 3.1 1.8e-07 30.8 0.0 7.1 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_3 PF13415.1 CDI83610.1 - 2e-25 88.3 7.0 4.5e-06 26.6 0.1 6.9 7 0 0 7 7 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 CDI83610.1 - 2.3e-20 71.5 1.0 0.0036 17.0 0.0 6.9 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 CDI83610.1 - 1.3e-14 53.6 3.0 0.027 14.4 0.0 6.8 7 0 0 7 7 7 3 Kelch motif BTB_2 PF02214.17 CDI83610.1 - 1.5e-13 50.7 0.0 4.4e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain PQQ_3 PF13570.1 CDI83610.1 - 0.001 19.2 0.2 6.5 7.1 0.0 4.2 4 0 0 4 4 4 1 PQQ-like domain DUF1668 PF07893.8 CDI83610.1 - 0.014 14.5 0.0 0.06 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) DUF1918 PF08940.6 CDI83610.1 - 0.051 12.9 0.0 0.2 10.9 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF342 PF03961.8 CDI83610.1 - 1 7.6 8.3 1.6 7.0 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3584 PF12128.3 CDI83610.1 - 1.8 5.7 18.4 2.4 5.3 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) OmpH PF03938.9 CDI83610.1 - 4 7.3 17.2 6.9 6.5 11.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Vfa1 PF08432.5 CDI83610.1 - 4.5 7.2 13.0 8.6 6.3 9.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 gpUL132 PF11359.3 CDI83611.1 - 0.12 11.6 0.9 0.41 9.9 0.6 1.8 1 0 0 1 1 1 0 Glycoprotein UL132 AP2 PF00847.15 CDI83613.1 - 1.2e-07 31.7 0.1 2e-07 31.0 0.0 5.8 8 0 0 8 8 8 2 AP2 domain AATF-Che1 PF13339.1 CDI83614.1 - 0.032 14.3 0.7 0.39 10.8 0.2 2.4 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor MCM PF00493.18 CDI83616.1 - 2.5e-120 401.2 0.1 3.1e-120 400.9 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 CDI83616.1 - 2e-07 30.4 0.1 1.9e-06 27.2 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 CDI83616.1 - 0.0012 18.4 0.0 0.0034 17.0 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI83616.1 - 0.0078 15.9 0.0 0.019 14.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RecX PF02631.11 CDI83616.1 - 0.029 14.5 0.1 0.075 13.2 0.1 1.6 1 0 0 1 1 1 0 RecX family Sigma54_activat PF00158.21 CDI83616.1 - 0.046 13.1 0.0 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.24 CDI83616.1 - 0.065 13.4 0.1 0.24 11.6 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BAG PF02179.11 CDI83616.1 - 0.066 13.3 0.5 0.066 13.3 0.3 2.6 3 0 0 3 3 3 0 BAG domain DUF2451 PF10474.4 CDI83616.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) EMG1 PF03587.9 CDI83617.1 - 3.6e-17 62.3 7.7 6.6e-16 58.2 1.1 3.9 2 1 0 2 2 2 1 EMG1/NEP1 methyltransferase Med15 PF09606.5 CDI83618.1 - 0.0002 19.7 55.2 0.0002 19.7 38.2 1.9 2 0 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Phosphorylase PF00343.15 CDI83622.1 - 8.7e-278 923.0 0.0 1e-277 922.8 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase UPF0561 PF10573.4 CDI83623.1 - 0.064 13.1 0.0 0.085 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 EGF_CA PF07645.10 CDI83624.1 - 3.6e-227 734.1 509.7 2.1e-12 46.8 7.3 33.8 32 1 1 33 33 33 27 Calcium-binding EGF domain EGF_3 PF12947.2 CDI83624.1 - 1.5e-155 504.7 526.7 9.2e-11 41.5 9.9 32.8 33 0 0 33 33 33 30 EGF domain cEGF PF12662.2 CDI83624.1 - 3.2e-140 455.0 292.6 1e-08 34.6 2.6 32.7 31 0 0 31 31 31 29 Complement Clr-like EGF-like EGF PF00008.22 CDI83624.1 - 1.5e-71 235.7 424.5 6e-06 26.1 4.6 32.3 31 0 0 31 31 31 27 EGF-like domain FXa_inhibition PF14670.1 CDI83624.1 - 1.3e-31 108.3 471.4 0.0015 18.5 3.9 32.2 27 4 4 31 31 31 25 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.2 CDI83624.1 - 8.4e-29 99.0 366.6 0.00014 21.5 3.9 32.2 32 0 0 32 32 32 22 MSP1 EGF domain 1 hEGF PF12661.2 CDI83624.1 - 1.9e-07 30.7 190.4 0.017 15.1 1.5 30.6 31 0 0 31 31 31 12 Human growth factor-like EGF Thioredoxin_6 PF13848.1 CDI83627.1 - 0.018 14.8 0.0 0.77 9.5 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_3 PF13192.1 CDI83627.1 - 0.073 12.8 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_2 PF13098.1 CDI83627.1 - 0.12 12.5 0.0 11 6.2 0.0 2.9 2 1 0 2 2 2 0 Thioredoxin-like domain DER1 PF04511.10 CDI83629.1 - 6.4e-19 68.2 0.0 2.6e-09 36.8 0.0 2.1 2 0 0 2 2 2 2 Der1-like family Ras PF00071.17 CDI83633.1 - 1.7e-40 138.0 0.1 2.3e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI83633.1 - 3.7e-09 37.1 0.1 1.7e-08 34.9 0.0 1.8 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CDI83633.1 - 5.5e-07 28.9 0.0 7.8e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDI83633.1 - 0.0001 21.8 0.0 0.00019 20.9 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CDI83633.1 - 0.0029 16.7 0.1 0.0052 15.9 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF2617 PF10936.3 CDI83635.1 - 0.0021 17.6 2.3 0.15 11.6 0.2 2.7 2 0 0 2 2 2 2 Protein of unknown function DUF2617 ACDC PF14733.1 CDI83636.1 - 1.4e-10 41.1 0.1 1.4e-10 41.1 0.0 1.9 2 0 0 2 2 2 1 AP2-coincident C-terminal AP2 PF00847.15 CDI83636.1 - 3.7e-06 26.9 0.5 3.7e-06 26.9 0.4 5.4 6 0 0 6 6 6 1 AP2 domain Dehydrin PF00257.14 CDI83636.1 - 0.009 16.3 0.3 24 5.2 0.0 3.5 3 1 0 3 3 3 1 Dehydrin Sterol-sensing PF12349.3 CDI83637.1 - 1.9e-06 27.4 12.0 1.8e-05 24.2 0.9 2.7 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 CDI83637.1 - 0.16 9.8 24.4 0.032 12.1 0.6 3.5 4 0 0 4 4 4 0 Patched family Hydrolase_4 PF12146.3 CDI83638.1 - 4.8e-06 26.3 0.3 0.073 12.9 0.0 2.4 2 0 0 2 2 2 2 Putative lysophospholipase Abhydrolase_5 PF12695.2 CDI83638.1 - 2.1e-05 24.3 1.3 2.1e-05 24.3 0.9 1.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDI83638.1 - 0.00012 22.0 0.1 0.00024 21.0 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family ATP-synt_10 PF05176.9 CDI83639.1 - 0.0073 15.6 0.0 0.48 9.6 0.0 2.1 2 0 0 2 2 2 2 ATP10 protein tRNA-synt_His PF13393.1 CDI83640.1 - 1e-09 37.8 0.1 1.8e-09 37.1 0.1 1.4 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.15 CDI83640.1 - 0.0042 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain DUF2153 PF09921.4 CDI83640.1 - 0.0053 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2153) DUF342 PF03961.8 CDI83642.1 - 1.1 7.6 5.7 1.7 6.9 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Trypan_PARP PF05887.6 CDI83643.1 - 0.015 15.1 8.3 0.021 14.6 5.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nop14 PF04147.7 CDI83643.1 - 0.024 12.6 21.8 0.026 12.4 15.1 1.0 1 0 0 1 1 1 0 Nop14-like family Plasmodium_Vir PF05795.6 CDI83643.1 - 0.045 12.9 2.5 0.051 12.7 1.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF2052 PF09747.4 CDI83643.1 - 0.057 13.3 25.8 0.067 13.1 17.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4175 PF13779.1 CDI83643.1 - 0.075 10.7 44.0 0.089 10.4 30.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) WLM PF08325.5 CDI83643.1 - 0.1 12.4 11.3 0.14 12.0 7.8 1.2 1 0 0 1 1 1 0 WLM domain SDA1 PF05285.7 CDI83643.1 - 0.14 11.3 24.0 0.16 11.2 16.6 1.0 1 0 0 1 1 1 0 SDA1 DUF4045 PF13254.1 CDI83643.1 - 0.17 11.1 15.0 0.19 10.9 10.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF1510 PF07423.6 CDI83643.1 - 0.35 10.2 25.0 0.42 9.9 17.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Band_3_cyto PF07565.8 CDI83643.1 - 0.42 10.0 15.3 0.46 9.9 10.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NCKAP5 PF15246.1 CDI83643.1 - 0.49 9.7 18.8 0.58 9.4 13.0 1.0 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein G-alpha PF00503.15 CDI83643.1 - 0.84 8.2 12.1 1.1 7.8 8.4 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Daxx PF03344.10 CDI83643.1 - 0.92 7.9 28.6 1.1 7.7 19.8 1.0 1 0 0 1 1 1 0 Daxx Family RNase_H2-Ydr279 PF09468.5 CDI83643.1 - 1 8.4 8.5 1.3 8.1 5.9 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) CDC45 PF02724.9 CDI83643.1 - 1.1 7.2 24.0 1.3 7.0 16.6 1.0 1 0 0 1 1 1 0 CDC45-like protein FLO_LFY PF01698.11 CDI83643.1 - 1.1 8.0 18.0 1.2 7.8 12.5 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF4220 PF13968.1 CDI83643.1 - 1.3 8.1 9.3 1.4 7.9 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) U79_P34 PF03064.11 CDI83643.1 - 1.6 8.1 17.1 2.1 7.7 11.8 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Raftlin PF15250.1 CDI83643.1 - 1.6 7.1 15.0 1.8 6.9 10.4 1.1 1 0 0 1 1 1 0 Raftlin XPG_I_2 PF12813.2 CDI83643.1 - 1.7 8.0 13.6 2 7.8 9.5 1.1 1 0 0 1 1 1 0 XPG domain containing TT_ORF1 PF02956.9 CDI83643.1 - 1.8 6.9 8.1 1.9 6.8 5.6 1.0 1 0 0 1 1 1 0 TT viral orf 1 AUX_IAA PF02309.11 CDI83643.1 - 1.8 8.2 12.5 2.2 8.0 8.6 1.2 1 0 0 1 1 1 0 AUX/IAA family DDHD PF02862.12 CDI83643.1 - 1.8 8.3 16.4 2.2 8.0 11.4 1.2 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.11 CDI83643.1 - 1.8 8.3 13.1 2.2 8.1 9.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CENP-T PF15511.1 CDI83643.1 - 1.9 7.6 21.6 2 7.5 15.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Spore_coat_CotO PF14153.1 CDI83643.1 - 1.9 7.8 31.5 2.5 7.5 21.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO GAGA_bind PF06217.7 CDI83643.1 - 2.1 8.2 15.8 2.4 8.0 11.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Vfa1 PF08432.5 CDI83643.1 - 2.3 8.1 22.5 2.9 7.8 15.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PRTP PF01366.13 CDI83643.1 - 2.6 5.9 13.8 3.2 5.6 9.6 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Hid1 PF12722.2 CDI83643.1 - 3 5.4 16.5 3.2 5.3 11.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NOA36 PF06524.7 CDI83643.1 - 3.4 6.8 18.0 4.3 6.5 12.4 1.1 1 0 0 1 1 1 0 NOA36 protein Cellulose_synt PF03552.9 CDI83643.1 - 3.6 5.7 6.7 4 5.6 4.7 1.1 1 0 0 1 1 1 0 Cellulose synthase SAPS PF04499.10 CDI83643.1 - 5.1 5.6 17.7 5.7 5.4 12.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2201_N PF13203.1 CDI83643.1 - 5.7 6.0 24.2 6.9 5.7 16.8 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain CRT10 PF08728.5 CDI83643.1 - 5.9 4.7 10.8 6.6 4.5 7.5 1.0 1 0 0 1 1 1 0 CRT10 VID27 PF08553.5 CDI83643.1 - 6.4 4.8 20.7 7.2 4.6 14.4 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Parvo_coat PF00740.13 CDI83643.1 - 6.4 5.6 16.6 7.2 5.4 11.5 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 TFIIF_alpha PF05793.7 CDI83643.1 - 7 4.8 24.9 8.9 4.5 17.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Paf1 PF03985.8 CDI83643.1 - 7.4 5.1 32.0 9.1 4.9 22.2 1.1 1 0 0 1 1 1 0 Paf1 Med19 PF10278.4 CDI83643.1 - 7.9 6.1 14.2 12 5.5 9.8 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF4303 PF14136.1 CDI83643.1 - 9.9 5.7 10.7 15 5.2 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) IncA PF04156.9 CDI83644.1 - 0.0017 17.9 16.5 0.0019 17.8 11.4 1.1 1 0 0 1 1 1 1 IncA protein TraT PF05818.7 CDI83644.1 - 0.0022 17.4 1.7 0.0024 17.3 1.2 1.0 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein DUF3260 PF11658.3 CDI83644.1 - 0.016 13.3 6.2 0.017 13.2 4.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Spt20 PF12090.3 CDI83644.1 - 0.018 14.4 5.9 0.017 14.4 4.1 1.2 1 0 0 1 1 1 0 Spt20 family TMEM51 PF15345.1 CDI83644.1 - 0.021 14.5 6.1 0.022 14.4 4.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4199 PF13858.1 CDI83644.1 - 0.034 14.0 2.7 0.045 13.6 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) FHIPEP PF00771.15 CDI83644.1 - 0.062 11.6 5.9 0.065 11.5 4.1 1.0 1 0 0 1 1 1 0 FHIPEP family Ctr PF04145.10 CDI83644.1 - 0.08 12.9 4.0 0.1 12.6 2.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family TPP_enzyme_N PF02776.13 CDI83644.1 - 0.095 12.1 5.7 0.11 11.9 3.9 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Serinc PF03348.10 CDI83644.1 - 0.16 10.6 5.1 0.16 10.6 3.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RskA PF10099.4 CDI83644.1 - 0.21 11.3 11.7 0.29 10.8 8.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA PAT1 PF09770.4 CDI83644.1 - 0.33 9.1 22.1 0.29 9.3 15.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_pp38 PF04846.8 CDI83644.1 - 0.33 10.2 2.0 0.56 9.5 1.4 1.4 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein OATP PF03137.15 CDI83644.1 - 0.54 8.2 3.5 0.58 8.1 2.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4557 PF15101.1 CDI83644.1 - 0.78 9.5 14.9 0.82 9.4 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Suf PF05843.9 CDI83644.1 - 1.5 8.4 13.5 1.6 8.4 9.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SHR3_chaperone PF08229.6 CDI83644.1 - 1.6 7.6 7.8 1.7 7.5 5.4 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 DUF2232 PF09991.4 CDI83644.1 - 2 7.3 4.3 2.2 7.1 3.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) MscS_TM PF12794.2 CDI83644.1 - 2 6.9 9.0 2.4 6.6 6.3 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 FimP PF09766.4 CDI83644.1 - 2.3 7.2 19.4 2.6 7.0 13.5 1.0 1 0 0 1 1 1 0 Fms-interacting protein Med15 PF09606.5 CDI83644.1 - 6.4 4.8 36.1 6.6 4.7 25.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Band_3_cyto PF07565.8 CDI83644.1 - 7.8 5.9 12.6 9.4 5.6 8.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4496 PF14908.1 CDI83644.1 - 8.1 6.3 9.6 10 5.9 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4496) AAA_23 PF13476.1 CDI83644.1 - 9.2 6.5 12.4 9.2 6.5 8.6 1.1 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.10 CDI83645.1 - 0.0014 17.8 4.3 0.0014 17.8 2.9 3.7 4 0 0 4 4 4 1 Exonuclease VII, large subunit SPX PF03105.14 CDI83645.1 - 0.17 11.6 20.9 0.11 12.1 3.2 3.7 3 1 1 4 4 4 0 SPX domain Mem_trans PF03547.13 CDI83645.1 - 1.9 6.6 7.2 0.21 9.8 0.1 2.5 2 0 0 2 2 2 0 Membrane transport protein Catalase-rel PF06628.7 CDI83646.1 - 2.5e-21 75.2 0.5 3.2e-21 74.9 0.3 1.1 1 0 0 1 1 1 1 Catalase-related immune-responsive DUF1658 PF07871.6 CDI83646.1 - 0.044 13.3 0.2 0.1 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) TBX PF12598.3 CDI83647.1 - 0.063 13.6 0.9 13 6.2 0.0 2.3 2 0 0 2 2 2 0 T-box transcription factor Ribosomal_60s PF00428.14 CDI83647.1 - 0.51 10.7 13.8 0.89 10.0 9.6 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Band_3_cyto PF07565.8 CDI83649.1 - 0.57 9.6 6.6 1.5 8.2 4.6 1.7 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.11 CDI83649.1 - 1.7 8.5 6.4 0.75 9.6 2.1 2.1 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GCC2_GCC3 PF07699.8 CDI83651.1 - 3.1e-06 26.6 28.5 0.042 13.4 2.4 5.5 2 2 4 6 6 5 4 GCC2 and GCC3 NCD3G PF07562.9 CDI83651.1 - 0.074 12.7 7.6 0.56 9.9 0.1 4.2 2 2 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR Asparaginase_2 PF01112.13 CDI83651.1 - 0.1 11.3 0.7 0.14 10.8 0.5 1.1 1 0 0 1 1 1 0 Asparaginase CBM_14 PF01607.19 CDI83651.1 - 5.1 7.1 13.5 5.6 6.9 0.2 4.6 2 2 1 3 3 3 0 Chitin binding Peritrophin-A domain TNFR_c6 PF00020.13 CDI83651.1 - 6.5 6.9 9.0 5 7.2 0.3 4.3 3 2 2 5 5 5 0 TNFR/NGFR cysteine-rich region RRM_1 PF00076.17 CDI83652.1 - 3e-08 33.1 0.0 8.4e-08 31.7 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI83652.1 - 1.7e-07 31.0 0.0 3.8e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) N6_N4_Mtase PF01555.13 CDI83654.1 - 0.03 13.8 0.0 4.8 6.6 0.0 3.2 1 1 0 1 1 1 0 DNA methylase CAF-1_p150 PF11600.3 CDI83655.1 - 0.0015 17.9 40.2 0.0015 17.9 27.9 7.8 2 2 5 7 7 7 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF617 PF04759.8 CDI83655.1 - 2.3 7.8 6.6 7.8 6.1 4.6 2.0 1 0 0 1 1 1 0 Protein of unknown function, DUF617 ABA_WDS PF02496.11 CDI83662.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 ABA/WDS induced protein DUF3006 PF11213.3 CDI83663.1 - 0.00046 19.8 1.4 0.00053 19.6 0.0 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF3006) PAT1 PF09770.4 CDI83663.1 - 0.0011 17.3 24.6 0.0011 17.3 17.1 1.3 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF342 PF03961.8 CDI83663.1 - 0.0058 15.0 7.0 0.0059 15.0 4.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Macoilin PF09726.4 CDI83663.1 - 0.0094 14.2 19.6 0.012 13.9 13.6 1.0 1 0 0 1 1 1 1 Transmembrane protein Peptidase_U57 PF05582.7 CDI83663.1 - 0.68 8.8 8.9 0.96 8.3 6.2 1.3 1 0 0 1 1 1 0 YabG peptidase U57 Peptidase_S49_N PF08496.5 CDI83663.1 - 3.7 7.3 12.0 6.5 6.5 8.3 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pap_E4 PF02711.9 CDI83663.1 - 6.6 7.6 19.2 17 6.3 0.0 2.3 2 0 0 2 2 2 0 E4 protein Ndc1_Nup PF09531.5 CDI83663.1 - 8.1 4.7 13.7 11 4.2 9.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CreD PF06123.7 CDI83663.1 - 8.6 4.7 13.3 13 4.2 9.2 1.2 1 0 0 1 1 1 0 Inner membrane protein CreD Dynactin_p62 PF05502.8 CDI83664.1 - 1.8e-12 46.7 11.8 1.1e-11 44.2 5.9 5.7 4 2 1 5 5 5 3 Dynactin p62 family Spt20 PF12090.3 CDI83664.1 - 0.019 14.3 16.1 0.22 10.8 1.6 3.4 3 0 0 3 3 3 0 Spt20 family FimP PF09766.4 CDI83664.1 - 9.2 5.2 26.4 0.2 10.6 4.6 3.6 3 0 0 3 3 3 0 Fms-interacting protein PARG_cat PF05028.9 CDI83667.1 - 2.4e-59 201.3 0.0 6.4e-58 196.6 0.0 2.6 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PhdYeFM_antitox PF02604.14 CDI83667.1 - 0.13 11.8 0.1 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system zf-C2H2_jaz PF12171.3 CDI83668.1 - 0.00012 22.1 1.8 0.00025 21.0 1.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDI83668.1 - 0.00012 22.1 1.8 0.0003 20.8 1.2 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.7 CDI83668.1 - 0.011 15.2 1.8 0.02 14.4 1.3 1.4 1 0 0 1 1 1 0 U1 zinc finger CBM_48 PF02922.13 CDI83669.1 - 4e-09 36.4 0.0 3.3e-07 30.2 0.0 2.4 1 1 1 2 2 2 2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) PP2C_2 PF13672.1 CDI83670.1 - 6.2e-07 29.0 0.0 2.4e-06 27.1 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CDI83670.1 - 1e-05 25.3 0.0 0.00011 21.9 0.0 2.5 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 CDI83670.1 - 0.011 15.1 0.0 0.63 9.3 0.0 2.3 2 0 0 2 2 2 0 Protein phosphatase 2C TSNR_N PF04705.7 CDI83670.1 - 0.031 14.0 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus Cohesin_HEAT PF12765.2 CDI83671.1 - 0.015 15.2 2.2 6.8 6.7 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion DKCLD PF08068.7 CDI83674.1 - 9.8e-26 89.4 0.0 2.3e-25 88.2 0.0 1.7 1 0 0 1 1 1 1 DKCLD (NUC011) domain TruB_N PF01509.13 CDI83674.1 - 1.3e-21 77.3 0.2 1.9e-19 70.3 0.1 2.7 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 CDI83674.1 - 1.6e-20 72.5 1.2 2.8e-20 71.8 0.8 1.4 1 0 0 1 1 1 1 PUA domain RR_TM4-6 PF06459.7 CDI83674.1 - 3.2 7.5 11.0 4.5 7.0 7.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Kinesin PF00225.18 CDI83675.1 - 2.2e-90 302.7 0.0 1.2e-88 297.0 0.0 2.8 2 1 0 2 2 2 1 Kinesin motor domain Ferrochelatase PF00762.14 CDI83676.1 - 9.3e-20 70.8 1.0 4e-10 39.1 0.5 2.6 2 0 0 2 2 2 2 Ferrochelatase SPX PF03105.14 CDI83676.1 - 0.0061 16.3 5.9 0.031 14.0 0.4 2.3 2 0 0 2 2 2 2 SPX domain Sec23_trunk PF04811.10 CDI83676.1 - 2.5 7.4 6.5 2.3 7.5 2.3 2.1 1 1 0 2 2 2 0 Sec23/Sec24 trunk domain Pex14_N PF04695.8 CDI83676.1 - 2.8 8.0 19.7 0.26 11.3 0.3 3.7 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PCI PF01399.22 CDI83678.1 - 1.1e-11 44.9 0.2 3e-11 43.5 0.1 1.7 1 0 0 1 1 1 1 PCI domain TPR_8 PF13181.1 CDI83678.1 - 0.042 13.6 0.3 7 6.6 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDI83678.1 - 0.089 12.7 2.2 0.65 10.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat AJAP1_PANP_C PF15298.1 CDI83679.1 - 0.0075 16.1 0.0 0.036 13.9 0.0 2.0 2 0 0 2 2 2 1 AJAP1/PANP C-terminus WD40 PF00400.27 CDI83680.1 - 0.0079 16.0 3.4 0.24 11.3 0.3 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Leader_Trp PF08255.6 CDI83680.1 - 0.27 10.9 5.0 0.83 9.4 3.5 1.8 1 0 0 1 1 1 0 Trp-operon Leader Peptide Dehydrin PF00257.14 CDI83681.1 - 0.0099 16.2 0.6 0.0099 16.2 0.4 1.8 2 0 0 2 2 2 1 Dehydrin MCM2_N PF12619.3 CDI83681.1 - 0.3 11.0 4.8 0.63 10.0 3.3 1.5 1 0 0 1 1 1 0 Mini-chromosome maintenance protein 2 Macoilin PF09726.4 CDI83681.1 - 0.48 8.6 3.2 0.66 8.1 2.2 1.1 1 0 0 1 1 1 0 Transmembrane protein Cytochrom_B_N PF00033.14 CDI83682.1 - 0.019 14.3 4.3 0.047 13.0 3.0 1.7 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Med15 PF09606.5 CDI83683.1 - 0.82 7.7 14.4 1 7.4 10.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal ResIII PF04851.10 CDI83685.1 - 1.5e-15 57.4 0.0 1.5e-15 57.4 0.0 3.1 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 CDI83685.1 - 3.4e-08 33.2 0.0 3.4e-08 33.2 0.0 3.2 3 1 0 3 3 3 1 Helicase conserved C-terminal domain Y_phosphatase3 PF13350.1 CDI83685.1 - 0.0097 16.1 4.3 0.026 14.7 0.0 2.7 2 0 0 2 2 2 1 Tyrosine phosphatase family AAA_22 PF13401.1 CDI83685.1 - 0.21 11.7 3.4 0.44 10.6 0.0 3.1 3 1 0 3 3 3 0 AAA domain PAT1 PF09770.4 CDI83685.1 - 2.2 6.4 45.5 0.38 8.9 24.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Evr1_Alr PF04777.8 CDI83687.1 - 1e-06 28.5 2.8 0.056 13.3 0.0 3.9 5 0 0 5 5 5 2 Erv1 / Alr family Thioredoxin PF00085.15 CDI83687.1 - 2.3e-06 27.2 0.0 4.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 CDI83687.1 - 0.00016 21.6 0.0 0.00042 20.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like DUF4106 PF13388.1 CDI83687.1 - 0.08 11.8 0.2 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) AhpC-TSA PF00578.16 CDI83687.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_2 PF13098.1 CDI83687.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain DUF3371 PF11851.3 CDI83689.1 - 4.8 7.8 7.8 25 5.5 0.2 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3371) LYTB PF02401.13 CDI83690.1 - 8.2e-13 47.8 0.1 1.1e-12 47.4 0.1 1.2 1 0 0 1 1 1 1 LytB protein Activator_LAG-3 PF11498.3 CDI83691.1 - 0.34 9.6 17.8 0.64 8.6 12.3 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MFS_1 PF07690.11 CDI83693.1 - 1.7e-28 99.4 21.6 1.7e-28 99.4 15.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2140 PF09911.4 CDI83693.1 - 0.0085 15.2 1.3 0.038 13.1 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2140) Ribosomal_60s PF00428.14 CDI83693.1 - 1.2 9.6 9.9 0.062 13.6 2.6 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein PSS PF03034.10 CDI83695.1 - 8.1e-52 176.3 14.3 1.1e-51 175.9 9.2 1.7 2 0 0 2 2 2 1 Phosphatidyl serine synthase Prog_receptor PF02161.10 CDI83695.1 - 1.1 8.0 5.0 1.6 7.4 3.5 1.1 1 0 0 1 1 1 0 Progesterone receptor DUF2217 PF10265.4 CDI83695.1 - 1.3 7.7 4.4 1.9 7.1 3.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF3357 PF11837.3 CDI83695.1 - 2.7 7.8 10.8 0.21 11.4 1.4 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3357) APCDDC PF14921.1 CDI83696.1 - 0.033 13.5 4.7 0.73 9.1 0.0 2.3 1 1 1 2 2 2 0 Adenomatosis polyposis coli down-regulated 1 Ndc1_Nup PF09531.5 CDI83696.1 - 0.32 9.3 16.9 0.43 8.9 11.7 1.2 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.17 CDI83696.1 - 0.42 9.5 4.1 0.6 9.0 2.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SOBP PF15279.1 CDI83696.1 - 4 7.7 14.6 5.1 7.3 10.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Peptidase_S64 PF08192.6 CDI83696.1 - 9.7 4.3 21.3 12 4.1 14.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 PAP_assoc PF03828.14 CDI83697.1 - 0.00023 21.0 0.0 0.00082 19.2 0.0 2.0 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 CDI83697.1 - 0.00026 21.2 0.0 0.0005 20.3 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain HEAT_EZ PF13513.1 CDI83699.1 - 2.5e-07 30.9 42.2 0.00036 20.9 1.0 8.4 8 1 1 9 9 9 4 HEAT-like repeat HEAT PF02985.17 CDI83699.1 - 0.0019 18.0 17.8 1.4 9.2 0.4 6.8 7 1 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.1 CDI83699.1 - 0.015 15.5 4.8 0.015 15.5 3.3 5.1 4 3 1 5 5 5 0 HEAT repeats NOC3p PF07540.6 CDI83699.1 - 0.16 12.2 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Nucleolar complex-associated protein AMMECR1 PF01871.12 CDI83702.1 - 5.3e-39 133.0 0.0 5.3e-39 133.0 0.0 2.1 3 0 0 3 3 3 1 AMMECR1 Exonuc_VII_L PF02601.10 CDI83702.1 - 0.15 11.1 14.6 0.31 10.1 10.1 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF912 PF06024.7 CDI83702.1 - 0.33 11.0 7.4 19 5.3 0.7 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Dermcidin PF15291.1 CDI83702.1 - 0.54 10.4 0.1 0.54 10.4 0.0 2.4 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide Jiraiya PF15038.1 CDI83702.1 - 2.4 7.5 8.7 1.1 8.6 0.5 2.5 2 0 0 2 2 2 0 Jiraiya EphA2_TM PF14575.1 CDI83702.1 - 4.7 7.6 5.9 78 3.7 0.0 3.4 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain PAT1 PF09770.4 CDI83702.1 - 5 5.2 42.5 8.8 4.4 29.4 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MDFI PF15316.1 CDI83702.1 - 6.3 6.7 12.9 0.43 10.5 1.7 2.5 2 1 0 2 2 2 0 MyoD family inhibitor Rep_fac-A_C PF08646.5 CDI83703.1 - 1.3e-33 115.7 0.4 2.7e-33 114.7 0.3 1.6 1 0 0 1 1 1 1 Replication factor-A C terminal domain DUF4503 PF14951.1 CDI83703.1 - 5.3e-05 21.5 0.1 8.7e-05 20.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) tRNA_anti-codon PF01336.20 CDI83703.1 - 0.00037 20.2 0.1 0.058 13.2 0.0 3.1 2 1 1 3 3 3 1 OB-fold nucleic acid binding domain OrfB_Zn_ribbon PF07282.6 CDI83703.1 - 0.064 12.9 0.7 0.2 11.3 0.5 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-TFIIB PF13453.1 CDI83703.1 - 0.07 12.3 2.6 0.13 11.4 1.8 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Ribosomal_L37ae PF01780.14 CDI83703.1 - 0.079 12.8 0.2 0.23 11.3 0.1 1.8 1 0 0 1 1 1 0 Ribosomal L37ae protein family UPF0547 PF10571.4 CDI83703.1 - 0.18 11.5 1.3 0.34 10.6 0.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 RNA_POL_M_15KD PF02150.11 CDI83703.1 - 0.19 11.4 1.0 0.39 10.4 0.7 1.4 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit C1_4 PF07975.7 CDI83703.1 - 0.66 10.0 3.0 2.2 8.3 2.1 1.9 1 0 0 1 1 1 0 TFIIH C1-like domain TIP120 PF08623.5 CDI83709.1 - 2.1e-07 30.6 0.0 2.1e-07 30.6 0.0 3.6 5 1 0 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT PF02985.17 CDI83709.1 - 0.12 12.5 0.0 0.12 12.5 0.0 7.8 7 0 0 7 7 7 0 HEAT repeat Pro-rich PF15240.1 CDI83710.1 - 1.1e-05 25.5 18.3 1.1e-05 25.5 12.7 2.2 2 0 0 2 2 2 1 Proline-rich CDC45 PF02724.9 CDI83710.1 - 0.0011 17.1 2.9 0.0011 17.1 2.0 1.5 2 0 0 2 2 2 1 CDC45-like protein Ycf1 PF05758.7 CDI83710.1 - 0.0028 15.4 5.1 0.0038 15.0 3.6 1.2 1 0 0 1 1 1 1 Ycf1 Spore_coat_CotO PF14153.1 CDI83710.1 - 0.004 16.6 11.0 0.004 16.6 7.6 1.9 2 0 0 2 2 2 1 Spore coat protein CotO Asp-B-Hydro_N PF05279.6 CDI83710.1 - 0.02 14.7 8.5 0.029 14.2 5.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TRAP_alpha PF03896.11 CDI83710.1 - 0.34 9.8 4.6 0.52 9.2 3.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FHIPEP PF00771.15 CDI83710.1 - 0.47 8.7 4.6 0.63 8.2 3.2 1.2 1 0 0 1 1 1 0 FHIPEP family AAA_23 PF13476.1 CDI83710.1 - 1 9.6 12.1 0.57 10.4 6.4 1.8 2 0 0 2 2 2 0 AAA domain HSP90 PF00183.13 CDI83710.1 - 2 6.7 11.1 4 5.7 7.7 1.5 1 1 0 1 1 1 0 Hsp90 protein DDHD PF02862.12 CDI83710.1 - 2.2 7.9 17.1 0.48 10.1 8.3 2.0 2 0 0 2 2 2 0 DDHD domain Suf PF05843.9 CDI83710.1 - 2.6 7.7 13.6 0.37 10.4 5.7 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Otopetrin PF03189.8 CDI83710.1 - 3.5 6.5 5.3 1.2 8.0 1.1 1.8 2 0 0 2 2 2 0 Otopetrin DUF2052 PF09747.4 CDI83710.1 - 4.2 7.2 22.3 0.51 10.2 11.5 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4557 PF15101.1 CDI83710.1 - 5.9 6.6 20.9 0.23 11.2 10.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Ndc1_Nup PF09531.5 CDI83710.1 - 6.1 5.1 14.9 0.37 9.1 6.0 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF1764 PF08576.5 CDI83710.1 - 6.3 7.6 18.4 2 9.2 9.1 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Zip PF02535.17 CDI83710.1 - 6.5 5.6 6.7 11 4.8 4.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.7 CDI83710.1 - 7.7 5.5 17.3 17 4.4 12.0 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paramyxo_ncap PF00973.14 CDI83710.1 - 8.1 5.0 10.7 14 4.1 7.4 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Rad17 PF03215.10 CDI83711.1 - 0.0045 15.7 0.0 0.0049 15.6 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 CDI83711.1 - 0.019 14.9 0.0 0.029 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain DNA_pol3_delta2 PF13177.1 CDI83711.1 - 0.041 13.5 0.0 0.049 13.2 0.0 1.3 1 1 0 1 1 1 0 DNA polymerase III, delta subunit DUF815 PF05673.8 CDI83711.1 - 0.087 11.7 0.0 0.097 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CAF1C_H4-bd PF12265.3 CDI83712.1 - 9.5e-19 67.0 0.1 2.3e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 CDI83712.1 - 5.4e-12 45.0 2.5 0.00072 19.3 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat MACPF PF01823.14 CDI83713.1 - 1.6e-37 129.2 0.0 1.6e-37 129.2 0.0 4.6 4 1 0 4 4 4 1 MAC/Perforin domain DUF4325 PF14213.1 CDI83714.1 - 0.0083 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4325) SnoaL PF07366.7 CDI83714.1 - 0.24 10.9 0.7 7.9 6.0 0.0 2.4 3 0 0 3 3 3 0 SnoaL-like polyketide cyclase 60KD_IMP PF02096.15 CDI83715.1 - 0.15 11.6 2.3 0.25 11.0 1.6 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein V_ATPase_I PF01496.14 CDI83715.1 - 0.68 7.7 7.1 0.94 7.2 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SKIP_SNW PF02731.10 CDI83715.1 - 1 8.8 15.9 0.081 12.3 7.3 1.8 2 0 0 2 2 2 0 SKIP/SNW domain Spc24 PF08286.6 CDI83715.1 - 3.9 7.1 14.4 7.9 6.2 9.9 1.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 AP2 PF00847.15 CDI83716.1 - 4.3e-06 26.7 1.8 4.3e-06 26.7 1.2 7.9 8 0 0 8 8 8 4 AP2 domain Macoilin PF09726.4 CDI83717.1 - 0.00071 17.9 1.6 0.00085 17.7 1.1 1.0 1 0 0 1 1 1 1 Transmembrane protein Myosin_tail_1 PF01576.14 CDI83717.1 - 0.011 13.4 1.2 0.014 13.1 0.9 1.0 1 0 0 1 1 1 0 Myosin tail DUF1612 PF07756.7 CDI83717.1 - 0.04 14.0 2.4 0.052 13.6 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1612) DUF3450 PF11932.3 CDI83717.1 - 0.098 11.9 1.6 0.15 11.3 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Acyl-CoA_dh_C PF12806.2 CDI83717.1 - 0.17 11.7 0.2 0.17 11.7 0.1 2.5 2 1 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like DUF4164 PF13747.1 CDI83717.1 - 0.36 10.9 4.0 0.86 9.7 2.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) TFIIA PF03153.8 CDI83717.1 - 0.51 10.1 5.0 0.64 9.8 3.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ATG16 PF08614.6 CDI83717.1 - 1.9 8.2 7.5 5.3 6.8 5.2 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3138 PF11336.3 CDI83717.1 - 3.1 5.8 9.1 4.6 5.2 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF416 PF04222.7 CDI83719.1 - 0.12 11.5 0.1 0.18 10.9 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF416) DegQ PF08181.6 CDI83719.1 - 0.25 11.0 1.6 0.29 10.8 0.4 1.7 2 0 0 2 2 2 0 DegQ (SacQ) family PLDc_2 PF13091.1 CDI83722.1 - 1.7e-05 24.5 13.4 0.00099 18.8 0.0 4.6 4 1 0 4 4 4 2 PLD-like domain PLDc PF00614.17 CDI83722.1 - 0.012 15.4 3.5 1.2 9.0 0.0 2.8 3 0 0 3 3 3 0 Phospholipase D Active site motif Menin PF05053.8 CDI83722.1 - 0.038 12.1 5.7 0.07 11.2 3.9 1.6 1 0 0 1 1 1 0 Menin BSD PF03909.12 CDI83723.1 - 3.5e-05 23.4 1.0 0.00011 21.8 0.0 2.3 2 0 0 2 2 2 1 BSD domain Peptidase_M16 PF00675.15 CDI83724.1 - 8e-21 74.3 0.0 8e-21 74.3 0.0 3.1 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) MSP1_C PF07462.6 CDI83725.1 - 0.2 9.9 26.4 0.82 7.9 7.5 2.4 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus TIM PF00121.13 CDI83726.1 - 1.6e-57 194.3 0.3 1.6e-55 187.8 0.2 2.0 1 1 0 1 1 1 1 Triosephosphate isomerase MT-A70 PF05063.9 CDI83727.1 - 5.5e-56 188.8 0.3 5.5e-56 188.8 0.2 3.5 4 0 0 4 4 4 1 MT-A70 LRR_4 PF12799.2 CDI83727.1 - 8.9e-15 53.9 19.8 0.00011 21.7 1.7 4.6 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) Caldesmon PF02029.10 CDI83727.1 - 0.0013 17.3 12.3 0.0013 17.3 8.5 6.2 5 2 0 6 6 6 1 Caldesmon zf-C3HC4_3 PF13920.1 CDI83728.1 - 1.5 8.5 39.7 0.4 10.3 13.4 4.1 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.27 CDI83729.1 - 2.9e-12 45.9 8.7 1.7e-05 24.5 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Methyltransf_26 PF13659.1 CDI83731.1 - 0.01 15.8 0.0 0.037 14.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Sad1_UNC PF07738.8 CDI83732.1 - 1e-15 57.7 0.0 2.1e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Rft-1 PF04506.8 CDI83733.1 - 1.4e-13 50.1 0.6 2.2e-08 32.9 0.0 3.0 3 0 0 3 3 3 3 Rft protein AP2 PF00847.15 CDI83734.1 - 6.4e-07 29.4 3.3 6.4e-07 29.4 2.3 5.0 2 0 0 2 2 2 1 AP2 domain Ras PF00071.17 CDI83735.1 - 4e-11 42.5 0.0 5.8e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Ras family OTCace_N PF02729.16 CDI83735.1 - 0.057 13.0 0.0 0.076 12.6 0.0 1.3 1 1 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Ras PF00071.17 CDI83736.1 - 6.5e-12 45.1 0.0 7.7e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI83736.1 - 6.2e-06 26.7 0.5 7.1e-06 26.5 0.3 1.1 1 0 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 CDI83736.1 - 0.00057 20.1 0.8 0.00082 19.6 0.6 1.2 1 0 0 1 1 1 1 ABC transporter Septin PF00735.13 CDI83736.1 - 0.00058 18.9 0.6 0.00069 18.7 0.4 1.1 1 0 0 1 1 1 1 Septin AAA_16 PF13191.1 CDI83736.1 - 0.00068 19.6 1.4 0.0013 18.7 1.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 CDI83736.1 - 0.0014 17.8 1.7 0.0018 17.4 1.2 1.3 1 1 0 1 1 1 1 Protein of unknown function, DUF258 DUF815 PF05673.8 CDI83736.1 - 0.0022 16.9 0.1 0.0029 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 CDI83736.1 - 0.0033 17.5 0.2 0.0056 16.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDI83736.1 - 0.0045 16.4 0.1 0.0088 15.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3987 PF13148.1 CDI83736.1 - 0.0067 15.0 0.7 0.0067 15.0 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) MMR_HSR1 PF01926.18 CDI83736.1 - 0.0079 16.1 0.0 0.012 15.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_5 PF07728.9 CDI83736.1 - 0.015 15.0 0.2 0.018 14.7 0.1 1.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.5 CDI83736.1 - 0.016 14.4 0.1 0.019 14.1 0.1 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Mg_chelatase PF01078.16 CDI83736.1 - 0.034 13.3 0.1 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 CDI83736.1 - 0.038 13.9 0.4 0.043 13.7 0.3 1.1 1 0 0 1 1 1 0 AAA domain Spt20 PF12090.3 CDI83736.1 - 0.052 12.8 4.5 0.045 13.1 3.1 1.1 1 0 0 1 1 1 0 Spt20 family AAA_24 PF13479.1 CDI83736.1 - 0.052 13.1 0.0 0.052 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 CDI83736.1 - 0.086 12.5 0.0 0.093 12.4 0.0 1.0 1 0 0 1 1 1 0 Archaeal ATPase Hpr_kinase_C PF07475.7 CDI83736.1 - 0.25 10.6 0.2 0.25 10.6 0.1 1.9 1 1 1 2 2 2 0 HPr Serine kinase C-terminal domain SHR3_chaperone PF08229.6 CDI83736.1 - 0.47 9.3 4.3 0.44 9.4 3.0 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 HlyD_2 PF12700.2 CDI83736.1 - 0.47 9.5 6.6 0.5 9.4 4.6 1.0 1 0 0 1 1 1 0 HlyD family secretion protein MCM PF00493.18 CDI83736.1 - 1.2 7.8 7.0 0.11 11.2 0.2 1.9 1 1 1 2 2 2 0 MCM2/3/5 family Suf PF05843.9 CDI83736.1 - 9.5 5.8 11.3 9.8 5.8 7.8 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4171 PF13775.1 CDI83738.1 - 0.029 14.5 4.5 0.038 14.1 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4171) Spt20 PF12090.3 CDI83739.1 - 0.017 14.5 17.7 0.73 9.1 0.6 3.3 3 0 0 3 3 3 0 Spt20 family EphA2_TM PF14575.1 CDI83739.1 - 1.4 9.3 13.9 1.8 8.9 0.1 3.7 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain SR-25 PF10500.4 CDI83739.1 - 1.5 8.2 0.0 0.11 11.9 3.9 4.9 4 1 0 4 4 4 0 Nuclear RNA-splicing-associated protein 2OG-FeII_Oxy_2 PF13532.1 CDI83740.1 - 9.4e-09 35.3 0.0 9.4e-09 35.3 0.0 8.4 10 1 0 10 10 10 1 2OG-Fe(II) oxygenase superfamily RCC1 PF00415.13 CDI83741.1 - 4.3e-18 65.2 14.8 6.4e-09 35.8 0.2 4.9 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI83741.1 - 0.015 14.9 29.7 0.43 10.2 4.7 5.9 4 1 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat Suf PF05843.9 CDI83743.1 - 0.0046 16.7 11.5 0.0061 16.3 8.0 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Paramyxo_ncap PF00973.14 CDI83743.1 - 0.0095 14.6 10.3 0.011 14.5 7.1 1.0 1 0 0 1 1 1 1 Paramyxovirus nucleocapsid protein PAT1 PF09770.4 CDI83743.1 - 0.022 13.0 31.6 0.022 13.0 21.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SAGA-Tad1 PF12767.2 CDI83743.1 - 0.025 14.2 11.0 0.026 14.2 7.6 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Serinc PF03348.10 CDI83743.1 - 0.034 12.8 7.5 0.033 12.9 5.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FLO_LFY PF01698.11 CDI83743.1 - 0.046 12.5 9.7 0.049 12.4 6.7 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF3449 PF11931.3 CDI83743.1 - 0.068 12.6 10.3 0.083 12.3 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) DDHD PF02862.12 CDI83743.1 - 0.088 12.5 7.9 0.091 12.5 5.5 1.1 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.1 CDI83743.1 - 0.089 12.9 8.0 0.099 12.8 5.6 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal AUX_IAA PF02309.11 CDI83743.1 - 0.11 12.2 6.9 0.11 12.1 4.8 1.1 1 0 0 1 1 1 0 AUX/IAA family DUF2215 PF10225.4 CDI83743.1 - 0.14 11.5 4.2 0.15 11.4 2.9 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) Het-C PF07217.6 CDI83743.1 - 0.15 10.1 6.0 0.16 10.1 4.2 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C RR_TM4-6 PF06459.7 CDI83743.1 - 0.17 11.7 10.8 0.2 11.5 7.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAA_13 PF13166.1 CDI83743.1 - 0.2 10.0 10.7 0.23 9.8 7.4 1.0 1 0 0 1 1 1 0 AAA domain HemX PF04375.9 CDI83743.1 - 0.2 10.2 29.7 0.26 9.8 20.6 1.0 1 0 0 1 1 1 0 HemX Spore_YhcN_YlaJ PF09580.5 CDI83743.1 - 0.24 11.5 9.6 0.28 11.2 6.7 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PBP_sp32 PF07222.7 CDI83743.1 - 0.25 10.5 14.2 0.28 10.3 9.9 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Neur_chan_memb PF02932.11 CDI83743.1 - 0.33 10.7 5.0 0.35 10.7 3.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2347 PF09804.4 CDI83743.1 - 0.34 10.1 6.2 0.38 9.9 4.3 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF1151 PF06625.6 CDI83743.1 - 0.37 10.5 22.9 0.5 10.1 15.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) DUF913 PF06025.7 CDI83743.1 - 0.47 9.1 4.4 0.48 9.1 3.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.3 CDI83743.1 - 0.48 9.1 14.9 0.66 8.6 10.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM60A PF15396.1 CDI83743.1 - 0.65 9.7 7.6 0.85 9.3 5.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Sec62 PF03839.11 CDI83743.1 - 0.69 9.2 9.0 0.88 8.9 6.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Glyco_transf_15 PF01793.11 CDI83743.1 - 1.1 8.1 12.2 1.3 7.8 8.5 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase AAA_23 PF13476.1 CDI83743.1 - 1.2 9.4 16.6 1.4 9.1 11.5 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.12 CDI83743.1 - 1.2 7.8 5.5 1.4 7.7 3.8 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_S15 PF02129.13 CDI83743.1 - 1.8 7.9 15.7 2.2 7.6 10.9 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) PBP1_TM PF14812.1 CDI83743.1 - 2.1 8.7 6.8 2.9 8.2 4.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rtf2 PF04641.7 CDI83743.1 - 2.4 7.2 13.8 3.9 6.6 9.6 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Rrn6 PF10214.4 CDI83743.1 - 2.7 5.9 16.6 2.8 5.9 11.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF3675 PF12428.3 CDI83743.1 - 2.7 8.2 9.8 5.2 7.3 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) Dala_Dala_lig_N PF01820.16 CDI83743.1 - 2.9 8.2 6.7 5 7.4 4.6 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus DHHW PF14286.1 CDI83743.1 - 3 7.0 8.3 3.9 6.6 5.7 1.1 1 0 0 1 1 1 0 DHHW protein MMR1 PF08505.5 CDI83743.1 - 3.1 7.7 15.6 3.3 7.6 10.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF2828 PF11443.3 CDI83743.1 - 3.1 5.8 10.2 4.1 5.4 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peroxin-13_N PF04088.8 CDI83743.1 - 3.5 7.5 7.3 5.8 6.8 5.1 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM176 PF14851.1 CDI83743.1 - 4.1 7.0 7.8 5.9 6.5 5.4 1.2 1 0 0 1 1 1 0 FAM176 family DDRGK PF09756.4 CDI83743.1 - 7.1 5.9 23.9 9.1 5.6 16.5 1.1 1 0 0 1 1 1 0 DDRGK domain Ycf1 PF05758.7 CDI83743.1 - 7.4 4.1 13.8 8.8 3.8 9.5 1.0 1 0 0 1 1 1 0 Ycf1 DUF3533 PF12051.3 CDI83743.1 - 8.1 5.0 7.4 8.7 4.9 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Gti1_Pac2 PF09729.4 CDI83743.1 - 9.4 6.0 11.0 13 5.6 7.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF1764 PF08576.5 CDI83743.1 - 9.8 7.0 17.4 16 6.2 12.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) AIF_C PF14721.1 CDI83743.1 - 9.9 6.4 14.5 0.52 10.5 6.1 1.7 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pkinase PF00069.20 CDI83744.1 - 5.2e-16 58.5 0.0 3.2e-09 36.3 0.0 7.4 6 1 0 6 6 6 2 Protein kinase domain Collagen PF01391.13 CDI83744.1 - 7.4e-07 28.6 34.3 7.4e-07 28.6 23.8 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) CAF-1_p150 PF11600.3 CDI83744.1 - 0.00052 19.4 25.5 0.00052 19.4 17.7 8.6 7 2 1 8 8 8 2 Chromatin assembly factor 1 complex p150 subunit, N-terminal EF-hand_1 PF00036.27 CDI83744.1 - 0.024 13.9 0.0 0.048 12.9 0.0 1.5 1 0 0 1 1 1 0 EF hand FMN_red PF03358.10 CDI83745.1 - 0.012 15.1 0.4 0.03 13.8 0.3 1.7 1 0 0 1 1 1 0 NADPH-dependent FMN reductase MFS_1 PF07690.11 CDI83747.1 - 7.8e-18 64.3 29.7 7.8e-18 64.3 20.6 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 CDI83747.1 - 1.2e-07 30.2 6.2 0.0012 17.0 0.2 2.7 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Nop PF01798.13 CDI83748.1 - 1.3e-51 173.8 0.2 1.3e-51 173.8 0.1 2.4 2 0 0 2 2 2 1 Putative snoRNA binding domain NOSIC PF08060.8 CDI83748.1 - 8.4e-22 76.7 0.1 1.4e-21 76.0 0.1 1.4 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 CDI83748.1 - 2.3e-14 53.2 0.1 8.2e-14 51.5 0.0 2.0 1 0 0 1 1 1 1 NOP5NT (NUC127) domain FancD2 PF14631.1 CDI83748.1 - 0.34 7.9 5.5 0.49 7.4 3.8 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease CT47 PF15623.1 CDI83748.1 - 2.7 7.6 27.4 5.7 6.6 19.0 1.4 1 0 0 1 1 1 0 Cancer/testis gene family 47 Metallophos PF00149.23 CDI83750.1 - 5.5e-45 153.2 0.3 6.7e-45 152.9 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AP2 PF00847.15 CDI83751.1 - 1.8e-07 31.2 0.4 1.8e-07 31.2 0.3 7.6 11 1 1 12 12 12 1 AP2 domain Kinesin PF00225.18 CDI83753.1 - 8.7e-99 330.3 0.0 8.7e-99 330.3 0.0 3.4 3 1 0 3 3 3 1 Kinesin motor domain CAP_GLY PF01302.20 CDI83754.1 - 1.3e-09 37.6 6.8 1.2e-08 34.5 4.7 2.1 1 1 0 1 1 1 1 CAP-Gly domain Med15 PF09606.5 CDI83754.1 - 0.0015 16.8 43.3 0.0015 16.8 30.0 3.4 3 1 0 3 3 3 1 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI83754.1 - 0.0024 17.6 10.6 0.0024 17.6 7.3 3.8 3 1 0 4 4 4 1 Suppressor of forked protein (Suf) MIP-T3 PF10243.4 CDI83754.1 - 0.018 13.5 28.7 0.012 14.1 8.9 2.6 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 SAPS PF04499.10 CDI83754.1 - 0.075 11.6 18.4 0.037 12.6 4.9 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Sec10 PF07393.6 CDI83754.1 - 0.89 7.6 22.3 0.0086 14.3 2.1 2.4 2 0 0 2 2 2 0 Exocyst complex component Sec10 RED_N PF07808.8 CDI83754.1 - 2.9 7.0 24.3 0.15 11.2 8.9 2.8 2 0 0 2 2 2 0 RED-like protein N-terminal region Mem_trans PF03547.13 CDI83754.1 - 3.1 6.0 15.6 0.68 8.1 0.4 2.6 2 0 0 2 2 2 0 Membrane transport protein Folate_carrier PF01770.13 CDI83754.1 - 8.4 4.7 16.7 0.1 11.1 4.2 2.6 3 0 0 3 3 3 0 Reduced folate carrier Rad21_Rec8 PF04824.11 CDI83760.1 - 0.00084 18.4 0.5 0.0028 16.7 0.4 1.9 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Dehydrin PF00257.14 CDI83761.1 - 9.6e-16 58.4 12.4 0.0039 17.5 0.0 8.8 7 2 0 8 8 8 1 Dehydrin SPRY PF00622.23 CDI83761.1 - 0.00016 21.7 0.0 0.0095 16.0 0.0 3.0 2 1 0 2 2 2 1 SPRY domain DUF4199 PF13858.1 CDI83761.1 - 5.2 6.9 0.0 5.2 6.9 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) zf-RING_2 PF13639.1 CDI83762.1 - 2e-11 43.5 11.0 4.7e-10 39.1 3.0 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDI83762.1 - 6.2e-09 35.7 6.5 6.8e-08 32.4 2.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI83762.1 - 2.6e-08 33.4 5.5 1.1e-07 31.4 1.1 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 CDI83762.1 - 5.8e-07 29.5 1.5 9.8e-06 25.5 0.1 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 CDI83762.1 - 1.5e-06 27.7 3.6 1.5e-06 27.7 2.5 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI83762.1 - 2.8e-06 26.8 7.7 1e-05 25.0 1.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDI83762.1 - 0.0032 17.3 5.8 0.0037 17.1 1.4 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CDI83762.1 - 0.0067 16.1 2.5 0.0067 16.1 1.7 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_4 PF14570.1 CDI83762.1 - 0.046 13.3 5.4 0.048 13.2 0.8 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 CDI83762.1 - 0.064 13.0 0.2 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 CDI83762.1 - 0.093 12.5 1.2 0.27 11.0 0.8 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.3 CDI83762.1 - 0.5 9.9 5.2 0.13 11.8 1.3 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Syja_N PF02383.13 CDI83767.1 - 1.3e-32 112.8 0.0 6.5e-16 57.9 0.0 3.2 2 1 0 2 2 2 2 SacI homology domain FHA PF00498.21 CDI83770.1 - 7.5e-14 51.6 0.0 5.7e-11 42.3 0.0 2.9 2 0 0 2 2 2 2 FHA domain RINGv PF12906.2 CDI83770.1 - 6.6e-13 48.4 6.1 1.7e-12 47.1 4.3 1.8 1 0 0 1 1 1 1 RING-variant domain Spore_coat_CotO PF14153.1 CDI83770.1 - 0.22 10.9 88.6 0.63 9.4 3.1 4.3 4 0 0 4 4 4 0 Spore coat protein CotO zf-RING_2 PF13639.1 CDI83770.1 - 1.2 8.9 5.7 2.7 7.9 4.0 1.6 1 0 0 1 1 1 0 Ring finger domain SAGA-Tad1 PF12767.2 CDI83770.1 - 1.7 8.2 77.0 0.46 10.0 2.6 4.3 4 0 0 4 4 4 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF1042 PF06294.6 CDI83771.1 - 6.3e-10 38.8 0.0 0.00039 20.0 0.0 2.3 1 1 1 2 2 2 2 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 CDI83771.1 - 2e-06 27.3 0.0 3.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain DUF3972 PF13118.1 CDI83771.1 - 0.0041 17.2 0.6 0.0063 16.5 0.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3972) M60-like PF13402.1 CDI83771.1 - 0.028 13.3 0.1 0.037 12.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase M60-like family CH PF00307.26 CDI83771.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 2 0 0 2 2 2 0 Calponin homology (CH) domain DUF641 PF04859.7 CDI83771.1 - 0.12 12.1 2.0 0.71 9.6 0.5 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FlgN PF05130.7 CDI83771.1 - 0.35 11.1 6.4 1.2 9.3 4.4 1.8 1 1 0 1 1 1 0 FlgN protein TMF_DNA_bd PF12329.3 CDI83771.1 - 2.9 7.7 7.1 5.5 6.8 0.0 2.4 2 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Adaptin_N PF01602.15 CDI83773.1 - 5.9e-32 110.6 0.6 1.8e-22 79.3 0.2 3.2 2 1 0 2 2 2 2 Adaptin N terminal region COP-gamma_platf PF08752.5 CDI83773.1 - 3.1e-08 33.5 0.0 1.3e-07 31.5 0.0 2.1 1 1 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain COX14 PF14880.1 CDI83774.1 - 1.3e-05 24.6 0.1 1.3e-05 24.6 0.1 3.3 3 1 0 3 3 3 1 Cytochrome oxidase c assembly AAA_23 PF13476.1 CDI83774.1 - 5.3 7.3 16.6 6.5 7.0 11.5 1.2 1 0 0 1 1 1 0 AAA domain SR-25 PF10500.4 CDI83775.1 - 3.2e-06 26.7 16.4 3.2e-06 26.7 11.3 6.0 5 1 0 5 5 5 2 Nuclear RNA-splicing-associated protein NAM-associated PF14303.1 CDI83775.1 - 0.0069 16.7 5.6 0.0069 16.7 3.9 4.1 2 1 1 3 3 3 1 No apical meristem-associated C-terminal domain Ribosomal_60s PF00428.14 CDI83775.1 - 0.03 14.7 1.2 0.03 14.7 0.8 8.4 8 0 0 8 8 8 0 60s Acidic ribosomal protein MIF4G PF02854.14 CDI83778.1 - 0.00017 21.0 2.1 0.00047 19.6 1.2 1.8 2 0 0 2 2 2 1 MIF4G domain LMBR1 PF04791.11 CDI83785.1 - 0.00038 19.1 2.4 0.00038 19.1 1.7 3.0 2 1 0 2 2 2 1 LMBR1-like membrane protein CDK2AP PF09806.4 CDI83785.1 - 0.011 15.9 1.6 0.011 15.9 1.1 3.5 3 1 0 3 3 3 0 Cyclin-dependent kinase 2-associated protein DUF1179 PF06678.6 CDI83785.1 - 0.043 14.1 0.7 0.16 12.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) E3_UbLigase_R4 PF13764.1 CDI83785.1 - 0.17 9.7 7.2 0.028 12.3 1.4 1.9 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 Neur_chan_memb PF02932.11 CDI83785.1 - 0.43 10.4 7.9 5 6.9 0.3 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4389 PF14333.1 CDI83785.1 - 3 7.6 7.2 0.31 10.7 0.5 2.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4389) AAA_23 PF13476.1 CDI83785.1 - 3.5 7.9 17.2 2.7 8.2 4.0 2.4 2 0 0 2 2 2 0 AAA domain Band_3_cyto PF07565.8 CDI83785.1 - 4.6 6.6 16.1 3.2 7.1 2.4 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Hexokinase_1 PF00349.16 CDI83787.1 - 5.4e-21 74.8 0.0 6.3e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Hexokinase DUF1510 PF07423.6 CDI83788.1 - 0.0019 17.6 20.2 0.0036 16.6 14.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Ycf1 PF05758.7 CDI83788.1 - 0.0046 14.7 14.4 0.0061 14.3 10.0 1.2 1 0 0 1 1 1 1 Ycf1 RNase_H2-Ydr279 PF09468.5 CDI83788.1 - 0.014 14.6 7.8 0.018 14.2 5.4 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Macoilin PF09726.4 CDI83788.1 - 0.026 12.8 23.5 0.036 12.3 16.3 1.3 1 0 0 1 1 1 0 Transmembrane protein GAGA_bind PF06217.7 CDI83788.1 - 0.061 13.2 21.4 0.099 12.5 14.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.9 CDI83788.1 - 0.071 11.1 20.7 0.1 10.6 14.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Membralin PF09746.4 CDI83788.1 - 0.17 10.8 9.4 0.25 10.3 6.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Neur_chan_memb PF02932.11 CDI83788.1 - 0.45 10.3 15.2 0.12 12.2 8.3 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.11 CDI83788.1 - 0.76 8.2 10.0 1 7.8 6.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TT_ORF1 PF02956.9 CDI83788.1 - 1.3 7.3 14.0 2.2 6.6 9.7 1.3 1 0 0 1 1 1 0 TT viral orf 1 PLRV_ORF5 PF01690.12 CDI83788.1 - 1.6 7.7 19.0 3.1 6.8 13.2 1.4 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Tetraspannin PF00335.15 CDI83788.1 - 2.5 7.3 7.4 6.1 6.0 5.1 1.6 1 1 0 1 1 1 0 Tetraspanin family Plasmodium_Vir PF05795.6 CDI83788.1 - 5.4 6.1 9.7 2.9 7.0 5.4 1.5 2 0 0 2 2 2 0 Plasmodium vivax Vir protein SID-1_RNA_chan PF13965.1 CDI83788.1 - 5.5 5.0 10.4 7.6 4.5 7.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hid1 PF12722.2 CDI83788.1 - 5.8 4.4 23.6 9.6 3.7 16.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF-3_zeta PF05091.7 CDI83788.1 - 6 5.3 26.5 8.6 4.8 18.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FLO_LFY PF01698.11 CDI83788.1 - 6.7 5.4 25.9 11 4.7 17.9 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF2009 PF09418.5 CDI83789.1 - 4.9e-107 358.5 4.1 5.7e-35 120.9 0.1 4.2 2 2 2 4 4 4 4 Protein of unknown function (DUF2009) Utp21 PF04192.7 CDI83789.1 - 0.026 13.6 0.3 0.14 11.2 0.2 2.0 1 1 0 1 1 1 0 Utp21 specific WD40 associated putative domain DUF4441 PF14536.1 CDI83790.1 - 0.0037 17.2 2.1 0.0058 16.6 1.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4441) Acetyltransf_1 PF00583.19 CDI83790.1 - 0.004 17.1 0.0 0.011 15.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 CDI83790.1 - 0.14 12.0 0.0 0.42 10.5 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Suf PF05843.9 CDI83790.1 - 1.8 8.1 7.0 2.9 7.5 4.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Insulin PF00049.13 CDI83790.1 - 4.2 8.2 7.0 26 5.6 0.2 2.7 2 1 0 2 2 2 0 Insulin/IGF/Relaxin family PAT1 PF09770.4 CDI83790.1 - 4.7 5.3 33.3 6.8 4.7 23.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DivIC PF04977.10 CDI83790.1 - 5.5 6.5 15.8 6.7 6.2 9.1 2.3 2 0 0 2 2 2 0 Septum formation initiator UQ_con PF00179.21 CDI83794.1 - 5.4e-53 178.1 0.0 6.1e-53 178.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDI83794.1 - 6.4e-06 25.9 0.0 7.6e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDI83794.1 - 0.0014 18.4 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 CDI83794.1 - 0.033 13.8 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain Suf PF05843.9 CDI83795.1 - 0.0039 16.9 12.2 0.0039 16.9 8.4 1.8 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) UPF0564 PF10595.4 CDI83795.1 - 0.026 13.4 19.8 0.043 12.7 13.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 DUF1634 PF07843.6 CDI83795.1 - 0.042 13.4 0.1 0.097 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) DUF3115 PF11312.3 CDI83795.1 - 0.079 11.8 3.2 0.14 10.9 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3115) RR_TM4-6 PF06459.7 CDI83795.1 - 0.089 12.6 10.2 0.17 11.7 7.1 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ycf1 PF05758.7 CDI83795.1 - 0.15 9.7 7.6 0.19 9.4 5.3 1.2 1 0 0 1 1 1 0 Ycf1 Presenilin PF01080.12 CDI83795.1 - 0.27 10.0 6.0 0.45 9.2 4.1 1.5 1 0 0 1 1 1 0 Presenilin SOBP PF15279.1 CDI83795.1 - 0.35 11.1 18.3 0.036 14.4 9.7 1.5 2 0 0 2 2 2 0 Sine oculis-binding protein Hid1 PF12722.2 CDI83795.1 - 0.48 8.0 11.8 0.67 7.5 8.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Bul1_C PF04426.7 CDI83795.1 - 0.94 8.6 18.4 0.052 12.7 9.0 1.5 2 0 0 2 2 2 0 Bul1 C terminus Neur_chan_memb PF02932.11 CDI83795.1 - 2.9 7.7 11.0 5.1 6.8 7.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RAB3GAP2_N PF14655.1 CDI83795.1 - 2.9 6.7 21.9 3.3 6.5 5.7 2.2 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus OmpH PF03938.9 CDI83795.1 - 3.4 7.5 43.3 0.048 13.5 17.6 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Lin-8 PF03353.10 CDI83795.1 - 3.9 6.6 16.6 7.9 5.6 11.5 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Paramyxo_ncap PF00973.14 CDI83795.1 - 5.1 5.6 8.4 7.2 5.1 5.8 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein LMBR1 PF04791.11 CDI83795.1 - 8.5 4.8 6.1 13 4.1 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FxsA PF04186.8 CDI83795.1 - 9.9 5.7 13.5 0.17 11.5 1.3 3.0 3 1 0 3 3 3 0 FxsA cytoplasmic membrane protein Rhodanese PF00581.15 CDI83796.1 - 1.6e-05 25.1 0.5 5.7e-05 23.4 0.1 2.2 2 0 0 2 2 2 1 Rhodanese-like domain DUF4512 PF14975.1 CDI83796.1 - 0.48 11.2 0.0 0.48 11.2 0.0 5.9 6 1 0 6 6 6 0 Domain of unknown function (DUF4512) AAA PF00004.24 CDI83796.1 - 1.6 8.8 4.5 32 4.7 0.0 3.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DnaJ PF00226.26 CDI83797.1 - 6.9e-10 38.5 0.1 1.5e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain SR-25 PF10500.4 CDI83798.1 - 0.0077 15.7 1.0 0.0077 15.7 0.7 8.1 6 2 1 7 7 7 1 Nuclear RNA-splicing-associated protein zf-DHHC PF01529.15 CDI83798.1 - 1.4 8.3 5.6 1.8 7.9 0.1 2.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase Exo_endo_phos PF03372.18 CDI83800.1 - 6.5e-05 22.9 0.0 0.00025 21.0 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Spt20 PF12090.3 CDI83800.1 - 0.041 13.2 0.0 0.041 13.2 0.0 6.2 4 1 0 4 4 4 0 Spt20 family ATP-synt_10 PF05176.9 CDI83802.1 - 0.0045 16.2 0.0 0.0084 15.4 0.0 1.4 1 0 0 1 1 1 1 ATP10 protein IMS PF00817.15 CDI83803.1 - 7.8e-10 38.7 1.3 3.4e-05 23.6 0.2 2.9 2 0 0 2 2 2 2 impB/mucB/samB family BRCT PF00533.21 CDI83803.1 - 0.089 12.9 0.0 0.89 9.7 0.0 2.4 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain DEAD PF00270.24 CDI83804.1 - 1.3e-38 132.1 0.0 1.3e-38 132.1 0.0 3.0 4 0 0 4 4 4 1 DEAD/DEAH box helicase DUF4217 PF13959.1 CDI83804.1 - 5.3e-15 54.7 0.4 1.2e-14 53.5 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 CDI83804.1 - 1.1e-06 28.4 0.0 1.1e-06 28.4 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DER1 PF04511.10 CDI83805.1 - 1.5e-31 109.4 7.0 1.8e-31 109.2 4.9 1.0 1 0 0 1 1 1 1 Der1-like family Maf1 PF09174.5 CDI83806.1 - 2e-24 86.4 1.1 6.2e-23 81.5 0.7 2.1 1 1 0 1 1 1 1 Maf1 regulator HSP90 PF00183.13 CDI83807.1 - 3.5e-169 563.6 24.6 4.5e-169 563.2 17.1 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.1 CDI83807.1 - 2.7e-11 43.2 0.1 2.7e-11 43.2 0.0 2.7 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDI83807.1 - 2.8e-09 36.6 0.0 5.6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DDHD PF02862.12 CDI83807.1 - 0.71 9.6 6.8 14 5.3 2.2 2.7 2 0 0 2 2 2 0 DDHD domain Vfa1 PF08432.5 CDI83807.1 - 4.8 7.1 20.4 7.7 6.5 7.2 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 zf-RING_2 PF13639.1 CDI83808.1 - 3.7e-12 45.8 10.4 5.3e-12 45.3 7.2 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDI83808.1 - 2.4e-08 33.9 3.1 3.6e-08 33.3 2.2 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 CDI83808.1 - 2.6e-08 33.7 6.8 3.7e-08 33.2 4.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDI83808.1 - 1.6e-07 30.8 8.0 2.2e-07 30.3 5.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDI83808.1 - 1.3e-06 28.1 2.9 2.2e-06 27.3 2.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 CDI83808.1 - 3.9e-06 26.4 6.8 5.8e-06 25.9 4.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain RINGv PF12906.2 CDI83808.1 - 1.6e-05 24.8 5.0 2.7e-05 24.1 3.5 1.3 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.20 CDI83808.1 - 0.0001 21.8 6.1 0.00017 21.1 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 CDI83808.1 - 0.00045 19.7 4.4 0.00072 19.0 3.1 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 CDI83808.1 - 0.0077 16.1 6.4 0.052 13.5 4.4 2.0 1 1 1 2 2 2 1 FANCL C-terminal domain zf-P11 PF03854.9 CDI83808.1 - 0.0081 15.6 0.9 0.0081 15.6 0.7 2.1 1 1 1 2 2 2 1 P-11 zinc finger Rad50_zn_hook PF04423.9 CDI83808.1 - 0.018 14.5 0.1 0.98 8.9 0.0 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif Baculo_RING PF05883.6 CDI83808.1 - 0.12 12.2 3.9 0.2 11.5 2.5 1.3 1 1 0 1 1 1 0 Baculovirus U-box/Ring-like domain Prok-RING_1 PF14446.1 CDI83808.1 - 0.59 9.9 7.6 0.43 10.3 2.2 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.1 CDI83808.1 - 0.77 9.5 5.2 1.5 8.5 0.4 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.20 CDI83809.1 - 5.2e-08 32.4 6.7 1.2e-07 31.2 4.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI83809.1 - 1.7e-07 31.1 8.3 3.7e-07 30.0 5.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI83809.1 - 2.4e-07 30.4 8.6 5.7e-07 29.2 6.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CDI83809.1 - 2e-06 27.4 5.6 4.7e-06 26.2 3.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CDI83809.1 - 2.2e-06 27.2 6.2 5.2e-06 26.0 4.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDI83809.1 - 0.00055 19.7 11.2 0.0017 18.1 7.8 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CDI83809.1 - 0.007 16.0 8.4 0.022 14.4 5.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Ribosomal_L18p PF00861.17 CDI83811.1 - 8.5e-40 135.6 0.1 1.8e-39 134.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 CDI83811.1 - 2.9e-32 111.0 7.3 2.9e-32 111.0 5.0 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region RCC1 PF00415.13 CDI83812.1 - 1.2e-62 207.8 41.5 6.5e-15 55.0 0.8 8.5 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI83812.1 - 8.4e-40 133.5 55.1 2.7e-09 36.3 1.4 8.4 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Kelch_2 PF07646.10 CDI83812.1 - 5.7e-05 22.7 6.7 13 5.7 0.0 5.8 5 0 0 5 5 5 2 Kelch motif CBM_X PF06204.6 CDI83812.1 - 0.00067 19.0 0.3 1.1 8.7 0.0 3.5 3 0 0 3 3 3 1 Putative carbohydrate binding domain Hira PF07569.6 CDI83812.1 - 0.0021 17.3 0.2 12 5.0 0.0 4.1 4 0 0 4 4 4 1 TUP1-like enhancer of split Kelch_6 PF13964.1 CDI83812.1 - 0.081 13.1 6.9 14 6.0 0.1 5.4 6 0 0 6 6 6 0 Kelch motif Kelch_4 PF13418.1 CDI83812.1 - 1.7 8.4 5.9 40 4.0 0.0 4.5 5 0 0 5 5 5 0 Galactose oxidase, central domain Thioredoxin PF00085.15 CDI83813.1 - 2.3e-36 123.6 0.0 2.5e-20 72.1 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.1 CDI83813.1 - 7.9e-12 45.3 0.0 1.3e-07 31.6 0.0 3.5 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 CDI83813.1 - 1.1e-06 28.7 0.1 0.0024 18.0 0.0 3.5 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDI83813.1 - 5.3e-06 26.4 0.0 0.23 11.6 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.1 CDI83813.1 - 0.0049 16.8 0.1 0.37 10.8 0.0 3.0 3 0 0 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.16 CDI83813.1 - 0.047 13.3 0.0 2.1 8.0 0.0 2.5 2 0 0 2 2 2 0 AhpC/TSA family Redoxin PF08534.5 CDI83813.1 - 0.11 12.0 0.2 0.71 9.4 0.0 2.4 3 0 0 3 3 3 0 Redoxin Thioredoxin_9 PF14595.1 CDI83813.1 - 0.17 11.4 0.0 3 7.4 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin Spt20 PF12090.3 CDI83814.1 - 2.8 7.2 36.4 0.015 14.6 2.2 4.4 4 0 0 4 4 4 0 Spt20 family DnaJ PF00226.26 CDI83816.1 - 3.6e-13 49.0 0.0 9.9e-13 47.6 0.0 1.8 1 1 0 1 1 1 1 DnaJ domain AP2 PF00847.15 CDI83817.1 - 3.6e-06 27.0 0.3 3.6e-06 27.0 0.2 2.4 2 0 0 2 2 2 1 AP2 domain CAP PF00188.21 CDI83819.1 - 0.00092 19.6 0.2 0.00092 19.6 0.1 3.0 2 2 0 2 2 2 1 Cysteine-rich secretory protein family PAT1 PF09770.4 CDI83819.1 - 0.0052 15.1 58.6 0.0064 14.8 40.6 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Utp14 PF04615.8 CDI83819.1 - 0.45 8.6 40.5 0.59 8.2 28.0 1.1 1 0 0 1 1 1 0 Utp14 protein MIP-T3 PF10243.4 CDI83819.1 - 0.56 8.6 49.7 0.9 7.9 34.5 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC45 PF02724.9 CDI83821.1 - 0.29 9.1 4.0 0.36 8.7 2.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 CDI83821.1 - 6.6 4.5 13.9 8.8 4.1 9.7 1.1 1 0 0 1 1 1 0 Nop14-like family Baculo_11_kDa PF06143.6 CDI83822.1 - 4.6 6.6 9.1 18 4.7 0.3 3.8 3 0 0 3 3 3 0 Baculovirus 11 kDa family Carboxyl_trans PF01039.17 CDI83823.1 - 0.075 11.3 2.2 0.1 10.9 1.5 1.1 1 0 0 1 1 1 0 Carboxyl transferase domain FLO_LFY PF01698.11 CDI83823.1 - 0.11 11.3 3.5 11 4.7 0.0 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein DUF342 PF03961.8 CDI83824.1 - 7.9 4.7 9.8 13 4.1 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TPR_12 PF13424.1 CDI83825.1 - 7.1e-13 48.2 0.0 9.8e-08 31.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 CDI83825.1 - 1e-07 31.6 3.5 0.017 15.0 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF1764 PF08576.5 CDI83826.1 - 3.4e-08 34.1 13.3 3.4e-08 34.1 9.2 4.4 1 1 3 4 4 4 1 Eukaryotic protein of unknown function (DUF1764) Shadoo PF14999.1 CDI83826.1 - 0.84 9.5 0.0 0.84 9.5 0.0 4.5 2 1 2 4 4 4 0 Shadow of prion protein, neuroprotective Sec3_C PF09763.4 CDI83827.1 - 5.7 4.9 6.9 9.1 4.2 0.2 2.0 2 0 0 2 2 2 0 Exocyst complex component Sec3 IspD PF01128.14 CDI83828.1 - 2.1e-15 56.8 14.4 1.7e-11 44.0 4.8 4.5 4 1 0 4 4 4 2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Nucleoside_tran PF01733.13 CDI83828.1 - 5 6.1 9.4 5.6 6.0 0.1 3.1 3 0 0 3 3 3 0 Nucleoside transporter AP2 PF00847.15 CDI83830.1 - 2.6e-10 40.2 1.0 5.1e-06 26.5 0.0 3.9 3 0 0 3 3 3 2 AP2 domain ACDC PF14733.1 CDI83830.1 - 1.2e-08 34.8 1.5 1.7e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 AP2-coincident C-terminal RAP1 PF07218.6 CDI83833.1 - 1.1 7.2 9.1 1.6 6.7 6.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MRP-S31 PF15433.1 CDI83833.1 - 3.6 6.9 24.7 0.018 14.4 8.5 2.5 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S31 Secretin_N_2 PF07655.8 CDI83833.1 - 4.1 7.8 23.0 0.51 10.7 12.5 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain YlbD_coat PF14071.1 CDI83833.1 - 6.3 6.8 14.6 7.2 6.7 3.1 3.5 3 0 0 3 3 3 0 Putative coat protein DUF2722 PF10846.3 CDI83836.1 - 0.0011 18.0 0.1 0.0011 18.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.8 CDI83836.1 - 0.0046 17.0 0.4 0.005 16.8 0.2 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Med15 PF09606.5 CDI83836.1 - 0.007 14.6 13.2 0.0074 14.5 9.2 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal EI24 PF07264.6 CDI83836.1 - 0.026 13.9 0.7 0.029 13.8 0.5 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF3371 PF11851.3 CDI83836.1 - 0.077 13.6 5.4 0.13 12.9 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Suf PF05843.9 CDI83836.1 - 0.096 12.4 3.7 0.12 12.1 2.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) WBP-1 PF11669.3 CDI83836.1 - 0.14 12.2 7.3 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 WW domain-binding protein 1 Spt20 PF12090.3 CDI83836.1 - 0.24 10.7 6.1 0.35 10.1 4.2 1.2 1 0 0 1 1 1 0 Spt20 family FCP1_C PF09309.5 CDI83836.1 - 1.4 8.1 4.7 1.9 7.7 3.2 1.1 1 0 0 1 1 1 0 FCP1, C-terminal Activator_LAG-3 PF11498.3 CDI83836.1 - 1.9 7.1 25.2 2.7 6.6 17.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 EphA2_TM PF14575.1 CDI83836.1 - 2.6 8.4 6.7 4.2 7.8 2.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain zf-DHHC PF01529.15 CDI83836.1 - 2.6 7.3 7.5 6.3 6.1 3.1 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase FimP PF09766.4 CDI83836.1 - 5.5 5.9 12.4 8.2 5.3 8.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein PAT1 PF09770.4 CDI83836.1 - 6.1 4.9 15.2 7.6 4.6 10.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_L18ae PF01775.12 CDI83837.1 - 5e-53 178.2 0.1 6.3e-53 177.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain Med27 PF11571.3 CDI83837.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.7 1 1 1 2 2 2 0 Mediator complex subunit 27 Spt20 PF12090.3 CDI83838.1 - 0.0018 17.6 0.4 0.0018 17.6 0.3 4.3 3 1 0 3 3 3 2 Spt20 family SAPS PF04499.10 CDI83838.1 - 0.0045 15.6 0.2 0.0045 15.6 0.1 2.5 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein HA2 PF04408.18 CDI83838.1 - 0.13 12.3 8.6 2.1 8.3 0.1 3.8 3 0 0 3 3 3 0 Helicase associated domain (HA2) PAT1 PF09770.4 CDI83838.1 - 0.82 7.8 74.5 1.1 7.4 10.1 3.2 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 Ycf1 PF05758.7 CDI83838.1 - 6.7 4.2 26.3 0.58 7.8 2.4 3.1 3 0 0 3 3 3 0 Ycf1 Pex14_N PF04695.8 CDI83839.1 - 0.00013 21.9 2.8 0.00016 21.6 1.9 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Secretin_N_2 PF07655.8 CDI83839.1 - 0.0031 17.8 8.1 0.0044 17.3 5.6 1.2 1 0 0 1 1 1 1 Secretin N-terminal domain Suf PF05843.9 CDI83839.1 - 0.096 12.4 2.1 0.099 12.3 1.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1183 PF06682.7 CDI83839.1 - 1.5 8.3 6.0 1.9 8.0 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) DUF912 PF06024.7 CDI83839.1 - 3.7 7.6 6.0 5.5 7.0 4.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CYSTM PF12734.2 CDI83839.1 - 4.3 7.5 5.8 2.5 8.2 2.1 2.0 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance FAM196 PF15265.1 CDI83840.1 - 1.5 7.9 14.7 1.8 7.6 10.2 1.1 1 0 0 1 1 1 0 FAM196 family Bud13 PF09736.4 CDI83841.1 - 2.6e-12 47.2 9.5 2.7e-11 43.9 4.3 2.8 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex AAA PF00004.24 CDI83842.1 - 2.5e-38 131.2 0.0 4.9e-38 130.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDI83842.1 - 1.3e-05 25.3 6.9 0.00079 19.4 4.8 3.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CDI83842.1 - 5.4e-05 23.3 0.5 0.0056 16.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CDI83842.1 - 0.00029 20.5 0.0 0.0011 18.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 CDI83842.1 - 0.0013 18.6 0.2 0.0052 16.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain PhoH PF02562.11 CDI83842.1 - 0.0016 17.7 0.1 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.1 CDI83842.1 - 0.002 17.8 0.5 0.0056 16.4 0.1 2.0 2 0 0 2 2 1 1 Part of AAA domain AAA_17 PF13207.1 CDI83842.1 - 0.0048 17.7 0.2 0.028 15.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CDI83842.1 - 0.011 15.1 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.8 CDI83842.1 - 0.014 14.1 0.0 0.058 12.1 0.0 1.9 2 0 0 2 2 2 0 TIP49 C-terminus RuvB_N PF05496.7 CDI83842.1 - 0.021 13.8 0.0 0.18 10.7 0.0 2.1 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 CDI83842.1 - 0.034 13.3 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 CDI83842.1 - 0.04 13.4 0.1 0.079 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 CDI83842.1 - 0.058 12.8 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 CDI83842.1 - 0.073 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.7 CDI83842.1 - 0.073 12.7 0.2 0.24 11.0 0.1 1.9 1 1 1 2 2 2 0 NACHT domain AAA_2 PF07724.9 CDI83842.1 - 0.098 12.5 0.0 0.24 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 CDI83842.1 - 0.13 12.5 0.1 0.41 10.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CDI83842.1 - 0.16 12.2 0.0 0.42 10.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 CDI83842.1 - 0.22 10.8 3.3 1.4 8.2 0.2 2.8 1 1 1 3 3 3 0 AAA domain RRM_1 PF00076.17 CDI83845.1 - 7.9e-37 124.7 0.1 2.1e-17 62.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI83845.1 - 4.5e-33 113.0 0.0 4.7e-17 61.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI83845.1 - 1.1e-18 66.8 0.0 3.4e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDI83845.1 - 2.2e-05 24.1 0.0 0.021 14.5 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif IncA PF04156.9 CDI83846.1 - 0.046 13.3 1.9 0.057 13.0 1.3 1.1 1 0 0 1 1 1 0 IncA protein DUF2730 PF10805.3 CDI83846.1 - 0.066 12.9 0.1 0.087 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) RPAP1_C PF08620.5 CDI83846.1 - 0.094 12.5 0.1 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 RPAP1-like, C-terminal Syntaxin_2 PF14523.1 CDI83846.1 - 0.097 12.7 2.0 0.11 12.4 1.4 1.2 1 0 0 1 1 1 0 Syntaxin-like protein MtaB PF12176.3 CDI83846.1 - 0.12 10.7 1.4 0.14 10.5 0.9 1.0 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit Bap31 PF05529.7 CDI83846.1 - 0.13 11.6 1.8 0.15 11.4 1.2 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like SHR3_chaperone PF08229.6 CDI83846.1 - 0.14 11.0 0.1 0.2 10.5 0.1 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 NPV_P10 PF05531.7 CDI83847.1 - 0.046 13.9 0.2 0.38 11.0 0.5 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.7 CDI83847.1 - 0.056 13.8 1.0 0.13 12.6 0.7 1.7 1 0 0 1 1 1 0 SlyX Ribosomal_60s PF00428.14 CDI83847.1 - 0.79 10.1 22.3 0.41 11.0 4.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3138 PF11336.3 CDI83847.1 - 1.3 7.0 13.0 0.026 12.7 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) DUF3597 PF12200.3 CDI83847.1 - 5.9 7.2 9.3 5.5 7.4 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) DUF3235 PF11574.3 CDI83847.1 - 8.4 6.7 14.7 2.2 8.5 2.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) NAD_synthase PF02540.12 CDI83849.1 - 0.11 11.3 2.5 7.1 5.4 0.4 2.4 2 0 0 2 2 2 0 NAD synthase DUF572 PF04502.8 CDI83849.1 - 4.5 6.4 9.1 5.7 6.0 6.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) PaaSYMP PF14738.1 CDI83850.1 - 2.3e-23 82.6 0.1 2.8e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 GRASP55_65 PF04495.9 CDI83851.1 - 1.4e-36 125.5 0.0 4.7e-35 120.5 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain Ribosomal_60s PF00428.14 CDI83851.1 - 0.0033 17.7 0.6 0.0033 17.7 0.4 2.7 3 0 0 3 3 3 1 60s Acidic ribosomal protein Med15 PF09606.5 CDI83851.1 - 0.059 11.5 27.9 0.08 11.1 19.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Pex14_N PF04695.8 CDI83851.1 - 0.22 11.5 13.1 0.31 11.0 1.7 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ETRAMP PF09716.5 CDI83851.1 - 1.8 8.5 5.8 5.7 6.9 3.2 2.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TraT PF05818.7 CDI83851.1 - 7.2 5.9 9.0 0.52 9.6 1.8 1.9 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein G-alpha PF00503.15 CDI83852.1 - 0.037 12.7 3.1 0.065 11.9 2.1 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Trehalose_PPase PF02358.11 CDI83853.1 - 0.0023 16.8 0.0 0.0023 16.8 0.0 2.3 1 1 1 2 2 1 1 Trehalose-phosphatase G-7-MTase PF12803.2 CDI83853.1 - 0.032 13.3 10.4 0.055 12.6 7.2 1.3 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Med5 PF08689.5 CDI83853.1 - 0.039 11.6 12.0 0.065 10.9 8.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit Med5 DUF1510 PF07423.6 CDI83853.1 - 0.04 13.2 23.1 0.12 11.6 16.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) LMBR1 PF04791.11 CDI83853.1 - 0.21 10.1 3.9 0.22 10.0 2.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Ycf1 PF05758.7 CDI83853.1 - 0.36 8.4 18.7 0.47 8.1 12.9 1.1 1 0 0 1 1 1 0 Ycf1 HlyD_2 PF12700.2 CDI83853.1 - 0.47 9.5 13.3 0.63 9.1 9.2 1.2 1 0 0 1 1 1 0 HlyD family secretion protein AAA_23 PF13476.1 CDI83853.1 - 0.98 9.7 23.0 1.6 9.0 16.0 1.3 1 0 0 1 1 1 0 AAA domain Mgr1 PF08602.5 CDI83853.1 - 1.5 7.7 9.5 2.3 7.1 6.6 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Herpes_DNAp_acc PF04929.7 CDI83853.1 - 4.5 6.1 24.6 0.18 10.7 11.4 2.1 2 0 0 2 2 2 0 Herpes DNA replication accessory factor CKAP2_C PF15297.1 CDI83853.1 - 5.1 5.8 25.4 9.2 4.9 17.6 1.3 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus CDC45 PF02724.9 CDI83853.1 - 5.8 4.8 25.7 9.2 4.1 17.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF572 PF04502.8 CDI83853.1 - 9.3 5.3 30.9 0.41 9.8 15.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Kinesin PF00225.18 CDI83854.1 - 2.3e-21 75.8 0.0 1.5e-15 56.7 0.0 2.5 2 0 0 2 2 2 2 Kinesin motor domain HSP20 PF00011.16 CDI83855.1 - 1.6e-18 66.4 0.0 2.6e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Cofilin_ADF PF00241.15 CDI83856.1 - 1.1e-30 106.1 0.0 1.4e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF1461 PF07314.6 CDI83857.1 - 0.14 11.8 0.9 0.22 11.2 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) Cytochrom_B_C PF00032.12 CDI83857.1 - 0.54 10.5 4.3 0.32 11.2 1.3 1.8 1 1 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD Rtf2 PF04641.7 CDI83858.1 - 9.3e-48 162.6 0.9 1.4e-47 162.0 0.6 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_UBOX PF13445.1 CDI83858.1 - 0.011 15.3 0.0 0.035 13.8 0.0 2.0 1 1 0 1 1 1 0 RING-type zinc-finger DUF1192 PF06698.6 CDI83858.1 - 0.1 12.4 2.7 0.31 10.9 1.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Pex14_N PF04695.8 CDI83858.1 - 0.18 11.8 13.1 0.029 14.4 3.7 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Striatin PF08232.7 CDI83858.1 - 2.1 8.6 8.5 11 6.3 4.5 2.2 2 0 0 2 2 2 0 Striatin family Aconitase PF00330.15 CDI83859.1 - 3e-143 477.6 0.0 3.7e-143 477.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CDI83859.1 - 1.5e-42 144.8 0.0 2.6e-42 144.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain LisH PF08513.6 CDI83859.1 - 0.14 11.9 0.2 0.83 9.5 0.0 2.3 2 0 0 2 2 2 0 LisH adh_short PF00106.20 CDI83861.1 - 6.2e-19 68.5 0.6 6.2e-19 68.5 0.4 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 CDI83861.1 - 3.9e-07 29.9 0.1 3.9e-07 29.9 0.1 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 CDI83861.1 - 4.3e-06 26.6 0.0 0.0019 18.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase FAM60A PF15396.1 CDI83861.1 - 0.037 13.7 2.1 0.063 13.0 1.4 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Suf PF05843.9 CDI83861.1 - 8.8 5.9 9.5 4.5 6.9 4.8 1.8 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) DUF1010 PF06231.6 CDI83864.1 - 1.9 8.5 5.2 2.5 8.1 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1010) RabGAP-TBC PF00566.13 CDI83865.1 - 8.2e-22 77.7 0.2 1.7e-21 76.6 0.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PBP1_TM PF14812.1 CDI83865.1 - 0.2 11.9 6.7 0.49 10.7 4.7 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal 5-nucleotidase PF06189.7 CDI83865.1 - 0.3 9.8 2.7 0.25 10.0 1.0 1.5 1 1 1 2 2 2 0 5'-nucleotidase SPRY PF00622.23 CDI83867.1 - 2.4e-13 50.2 0.0 3.7e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 SPRY domain LisH PF08513.6 CDI83867.1 - 0.0055 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 LisH zf-CCCH PF00642.19 CDI83868.1 - 8.2e-18 63.6 19.1 2.4e-08 33.4 1.3 3.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CDI83868.1 - 2.9e-07 30.2 19.7 0.00048 20.0 1.1 4.2 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type MIP-T3 PF10243.4 CDI83869.1 - 5.1e-05 21.9 42.5 5.1e-05 21.9 29.5 5.4 2 2 2 5 5 5 1 Microtubule-binding protein MIP-T3 Ribosomal_60s PF00428.14 CDI83871.1 - 2.3e-22 79.1 13.9 3.3e-22 78.7 9.6 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2336 PF10098.4 CDI83871.1 - 0.021 14.0 0.4 0.026 13.7 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2336) DUF4349 PF14257.1 CDI83871.1 - 1.9 7.6 5.9 3.1 6.9 3.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) ING PF12998.2 CDI83872.1 - 1.2 9.4 12.0 0.21 11.8 0.7 3.4 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Fig1 PF12351.3 CDI83873.1 - 0.022 14.6 0.2 0.059 13.2 0.1 1.7 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Peptidase_S49_N PF08496.5 CDI83873.1 - 0.093 12.5 8.3 0.71 9.6 0.2 3.9 3 0 0 3 3 3 0 Peptidase family S49 N-terminal FHA PF00498.21 CDI83874.1 - 8.8e-08 32.1 0.0 2.7e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 FHA domain Methyltransf_11 PF08241.7 CDI83875.1 - 9.5e-06 26.0 0.0 9.5e-06 26.0 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDI83875.1 - 2.7e-05 23.7 0.2 2.7e-05 23.7 0.1 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDI83875.1 - 2.8e-05 24.6 1.9 5.5e-05 23.7 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain AAA_23 PF13476.1 CDI83875.1 - 7.6e-05 23.1 3.9 9.5e-05 22.8 2.7 1.1 1 0 0 1 1 1 1 AAA domain Methyltransf_23 PF13489.1 CDI83875.1 - 0.0001 22.0 0.0 0.0001 22.0 0.0 2.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDI83875.1 - 0.00026 21.3 0.2 0.0011 19.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDI83875.1 - 0.00035 20.5 1.6 0.0013 18.7 0.2 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDI83875.1 - 0.00068 20.0 0.1 0.00068 20.0 0.1 2.9 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.9 CDI83875.1 - 0.0013 18.1 0.0 0.0033 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain CIAPIN1 PF05093.8 CDI83875.1 - 0.025 14.6 0.4 0.025 14.6 0.3 3.4 2 1 0 2 2 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Pex14_N PF04695.8 CDI83875.1 - 0.2 11.6 32.0 0.11 12.5 2.8 3.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PrmA PF06325.8 CDI83875.1 - 0.44 9.6 7.7 0.045 12.8 1.5 2.0 1 1 1 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.6 CDI83875.1 - 1.6 7.3 5.1 0.28 9.8 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) Band_3_cyto PF07565.8 CDI83875.1 - 5 6.5 20.1 0.37 10.2 0.4 2.5 3 0 0 3 3 3 0 Band 3 cytoplasmic domain UPF0547 PF10571.4 CDI83876.1 - 0.16 11.7 0.3 0.16 11.7 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 RAP1 PF07218.6 CDI83876.1 - 0.2 9.7 9.4 0.22 9.6 6.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2217 PF10265.4 CDI83876.1 - 3.7 6.2 11.9 6.4 5.4 8.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) AAA_23 PF13476.1 CDI83877.1 - 0.17 12.1 7.3 0.52 10.6 0.5 2.7 2 1 0 2 2 2 0 AAA domain CENP-B_dimeris PF09026.5 CDI83877.1 - 1.4 9.1 5.5 4.4 7.6 3.7 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SNase PF00565.12 CDI83878.1 - 1e-08 35.4 2.1 2.9e-07 30.6 0.0 3.1 2 1 1 3 3 3 2 Staphylococcal nuclease homologue Gly-zipper_YMGG PF13441.1 CDI83879.1 - 1.4 8.4 8.7 10 5.7 6.0 2.2 1 1 0 1 1 1 0 YMGG-like Gly-zipper DNA_methylase PF00145.12 CDI83880.1 - 4.2e-36 124.7 0.0 1.8e-34 119.3 0.0 2.1 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Pkinase PF00069.20 CDI83881.1 - 1.8e-16 60.0 0.0 4.9e-14 52.1 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83881.1 - 4.7e-08 32.4 0.0 5.6e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDI83881.1 - 0.002 17.1 0.0 0.0027 16.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like LCAT PF02450.10 CDI83882.1 - 4.4e-37 127.9 0.0 2.2e-30 105.9 0.2 2.1 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase OmpH PF03938.9 CDI83883.1 - 0.0038 17.1 7.5 0.0038 17.1 5.2 6.5 6 1 0 6 6 6 2 Outer membrane protein (OmpH-like) Spt20 PF12090.3 CDI83883.1 - 0.018 14.3 19.6 2 7.7 3.2 4.4 4 0 0 4 4 4 0 Spt20 family Herpes_UL87 PF03043.9 CDI83886.1 - 0.4 9.0 21.8 0.62 8.3 15.1 1.3 1 0 0 1 1 1 0 Herpesvirus UL87 family SGT1 PF07093.6 CDI83886.1 - 2.6 6.3 33.8 3.5 5.8 23.4 1.1 1 0 0 1 1 1 0 SGT1 protein HemX PF04375.9 CDI83886.1 - 5.6 5.4 68.7 0.21 10.1 14.4 2.2 2 0 0 2 2 2 0 HemX MACPF PF01823.14 CDI83890.1 - 4.3e-33 114.8 0.0 4.3e-33 114.8 0.0 3.2 4 0 0 4 4 4 1 MAC/Perforin domain VIT1 PF01988.14 CDI83891.1 - 0.0088 15.5 1.0 0.021 14.3 0.7 1.6 1 0 0 1 1 1 1 VIT family EF-hand_7 PF13499.1 CDI83891.1 - 0.025 14.7 0.1 0.088 12.9 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 CDI83891.1 - 0.049 12.9 0.2 0.16 11.3 0.1 2.0 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.1 CDI83891.1 - 0.051 13.1 2.7 0.079 12.5 0.4 2.5 3 0 0 3 3 3 0 EF-hand domain pair AAA_2 PF07724.9 CDI83892.1 - 2.8e-39 134.7 0.0 3.5e-38 131.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 CDI83892.1 - 2.6e-22 79.4 0.0 4.3e-12 46.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI83892.1 - 3e-13 49.7 0.4 8.9e-08 31.9 0.0 3.9 4 1 0 4 4 3 2 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.4 CDI83892.1 - 3.5e-13 49.2 0.0 1.4e-12 47.2 0.0 2.1 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.1 CDI83892.1 - 2.4e-12 47.2 6.7 1.5e-05 25.0 0.0 4.8 5 1 0 6 6 4 2 AAA ATPase domain Sigma54_activat PF00158.21 CDI83892.1 - 3e-09 36.5 0.1 2.2e-06 27.2 0.0 3.1 2 2 0 2 2 2 1 Sigma-54 interaction domain Arch_ATPase PF01637.13 CDI83892.1 - 3e-09 36.9 2.8 0.035 13.8 0.1 3.9 2 2 0 3 3 3 2 Archaeal ATPase AAA_22 PF13401.1 CDI83892.1 - 1.4e-08 34.9 1.7 0.0015 18.6 0.1 4.7 2 2 1 3 3 3 2 AAA domain RuvB_N PF05496.7 CDI83892.1 - 8.5e-07 28.2 0.7 0.014 14.5 0.0 3.4 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CDI83892.1 - 9.6e-07 29.6 0.2 0.046 14.5 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.1 CDI83892.1 - 1.2e-06 28.4 0.1 0.066 13.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain Zeta_toxin PF06414.7 CDI83892.1 - 1.8e-06 27.1 1.4 0.0046 16.0 0.0 3.8 4 0 0 4 4 4 1 Zeta toxin AAA_18 PF13238.1 CDI83892.1 - 6e-06 26.5 0.2 0.22 11.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain DUF258 PF03193.11 CDI83892.1 - 3.9e-05 22.9 0.0 0.22 10.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 NACHT PF05729.7 CDI83892.1 - 0.00012 21.7 0.1 0.29 10.7 0.1 3.2 2 1 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.12 CDI83892.1 - 0.00016 21.1 0.0 0.58 9.5 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein DUF815 PF05673.8 CDI83892.1 - 0.00029 19.8 2.7 0.58 9.0 0.1 3.7 4 1 0 4 4 4 2 Protein of unknown function (DUF815) RNA_helicase PF00910.17 CDI83892.1 - 0.00086 19.4 0.0 1.5 9.0 0.0 2.8 2 0 0 2 2 2 1 RNA helicase Bac_DnaA PF00308.13 CDI83892.1 - 0.0013 18.4 0.1 0.47 10.0 0.0 2.9 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_25 PF13481.1 CDI83892.1 - 0.0021 17.4 0.4 0.72 9.2 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.1 CDI83892.1 - 0.0022 17.6 0.1 0.41 10.4 0.1 3.0 2 0 0 2 2 2 1 Part of AAA domain AAA_28 PF13521.1 CDI83892.1 - 0.0048 16.8 0.0 5 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 CDI83892.1 - 0.005 17.3 0.0 1.9 8.9 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein ABC_tran PF00005.22 CDI83892.1 - 0.0056 16.9 0.5 0.58 10.4 0.0 3.0 2 1 0 2 2 2 1 ABC transporter TIP49 PF06068.8 CDI83892.1 - 0.0061 15.3 0.8 0.59 8.7 0.0 2.5 2 0 0 2 2 2 1 TIP49 C-terminus AAA_3 PF07726.6 CDI83892.1 - 0.0086 15.6 0.1 19 4.8 0.0 3.8 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 CDI83892.1 - 0.013 15.2 0.7 5.8 6.5 0.1 3.2 2 1 0 3 3 3 0 NTPase Mg_chelatase PF01078.16 CDI83892.1 - 0.017 14.3 0.3 2.3 7.3 0.0 2.8 4 0 0 4 4 2 0 Magnesium chelatase, subunit ChlI MobB PF03205.9 CDI83892.1 - 0.018 14.7 2.6 4.6 6.9 0.0 3.2 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_11 PF13086.1 CDI83892.1 - 0.023 14.2 0.1 0.18 11.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain Torsin PF06309.6 CDI83892.1 - 0.028 14.3 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 1 0 Torsin AAA_33 PF13671.1 CDI83892.1 - 0.03 14.2 3.3 2.1 8.2 0.0 3.1 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.4 CDI83892.1 - 0.036 13.5 0.0 1.2 8.6 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.17 CDI83892.1 - 0.051 12.4 1.5 4.8 5.9 0.0 3.6 5 0 0 5 5 5 0 NB-ARC domain AAA_10 PF12846.2 CDI83892.1 - 0.059 12.7 0.1 2.7 7.3 0.0 2.9 2 1 1 3 3 3 0 AAA-like domain DNA_pol3_delta2 PF13177.1 CDI83892.1 - 0.073 12.7 0.0 2.5 7.7 0.0 2.6 2 0 0 2 2 2 0 DNA polymerase III, delta subunit UPF0079 PF02367.12 CDI83892.1 - 0.084 12.4 0.1 13 5.4 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 CDI83892.1 - 0.2 11.1 2.8 8.7 5.9 0.0 3.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain NEP PF10167.4 CDI83894.1 - 0.027 14.1 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein HALZ PF02183.13 CDI83895.1 - 3.3 7.5 15.1 0.64 9.7 0.5 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper AP2 PF00847.15 CDI83897.1 - 5.3e-05 23.2 0.2 0.013 15.6 0.0 3.4 2 0 0 2 2 2 1 AP2 domain Pal1 PF08316.6 CDI83897.1 - 0.14 12.5 15.1 0.22 11.9 1.6 2.9 2 0 0 2 2 2 0 Pal1 cell morphology protein TFIIA PF03153.8 CDI83897.1 - 0.54 10.0 40.8 0.056 13.3 11.4 2.7 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Adaptin_binding PF10199.4 CDI83897.1 - 0.7 10.1 20.2 0.063 13.5 2.3 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 PAT1 PF09770.4 CDI83897.1 - 1.8 6.6 47.9 0.15 10.2 17.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Suf PF05843.9 CDI83897.1 - 2.1 8.0 26.1 0.33 10.6 6.0 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) zf-P11 PF03854.9 CDI83897.1 - 2.6 7.5 11.2 4.7 6.7 7.7 1.4 1 0 0 1 1 1 0 P-11 zinc finger eIF-3_zeta PF05091.7 CDI83897.1 - 3.3 6.2 22.9 0.027 13.1 3.9 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SAGA-Tad1 PF12767.2 CDI83897.1 - 4.6 6.8 24.6 0.47 10.0 4.7 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Folate_carrier PF01770.13 CDI83897.1 - 8 4.8 4.6 17 3.8 3.2 1.4 1 0 0 1 1 1 0 Reduced folate carrier Shikimate_dh_N PF08501.6 CDI83898.1 - 4.5e-07 29.8 0.1 2.4e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 CDI83898.1 - 5.8e-06 26.4 1.1 0.0033 17.5 0.0 2.8 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase SKI PF01202.17 CDI83898.1 - 0.018 14.9 0.4 0.018 14.9 0.2 4.2 3 1 0 3 3 3 0 Shikimate kinase IncA PF04156.9 CDI83900.1 - 6.8e-05 22.5 7.9 6.8e-05 22.5 5.5 3.7 2 1 0 2 2 2 1 IncA protein RNase_PH_C PF03725.10 CDI83900.1 - 0.00043 20.1 0.0 0.00083 19.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 FLO_LFY PF01698.11 CDI83900.1 - 0.4 9.4 19.0 0.11 11.2 9.2 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein CDC27 PF09507.5 CDI83900.1 - 5 6.2 25.4 0.34 10.0 12.1 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 HD-ZIP_N PF04618.7 CDI83900.1 - 7.8 7.0 9.3 1.2e+02 3.2 0.0 2.9 3 0 0 3 3 3 0 HD-ZIP protein N terminus LMBR1 PF04791.11 CDI83901.1 - 2.8e-05 22.9 6.8 3.2e-05 22.7 4.7 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Med15 PF09606.5 CDI83901.1 - 3.7e-05 22.1 56.7 4.1e-05 22.0 39.3 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI83901.1 - 0.00015 20.2 43.0 0.00016 20.1 29.8 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 SprA-related PF12118.3 CDI83901.1 - 0.00076 18.9 56.8 0.0013 18.1 39.4 1.4 1 0 0 1 1 1 1 SprA-related family CAF-1_p150 PF11600.3 CDI83901.1 - 0.0011 18.3 35.7 0.0017 17.7 24.8 1.2 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal FLO_LFY PF01698.11 CDI83901.1 - 0.0013 17.6 21.6 0.0017 17.2 15.0 1.1 1 0 0 1 1 1 1 Floricaula / Leafy protein AAA_23 PF13476.1 CDI83901.1 - 0.0033 17.7 17.9 0.0039 17.5 12.4 1.1 1 0 0 1 1 1 1 AAA domain Spore_coat_CotO PF14153.1 CDI83901.1 - 0.0035 16.7 26.8 0.005 16.3 18.6 1.4 1 0 0 1 1 1 1 Spore coat protein CotO eIF-3_zeta PF05091.7 CDI83901.1 - 0.011 14.4 23.2 0.012 14.2 16.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SR-25 PF10500.4 CDI83901.1 - 0.012 15.1 31.8 0.012 15.1 22.1 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.8 CDI83901.1 - 0.014 15.3 47.3 0.016 15.1 32.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOBP PF15279.1 CDI83901.1 - 0.02 15.2 27.9 0.023 15.1 19.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Pilt PF15453.1 CDI83901.1 - 0.025 14.2 33.7 0.032 13.9 23.4 1.1 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions UPF0564 PF10595.4 CDI83901.1 - 0.026 13.4 35.3 0.03 13.2 24.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 RR_TM4-6 PF06459.7 CDI83901.1 - 0.026 14.4 25.4 0.036 13.9 17.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Utp14 PF04615.8 CDI83901.1 - 0.037 12.1 29.4 0.043 11.9 20.4 1.0 1 0 0 1 1 1 0 Utp14 protein VIT1 PF01988.14 CDI83901.1 - 0.064 12.7 16.7 2.3 7.6 11.6 2.2 1 1 0 1 1 1 0 VIT family Asp-B-Hydro_N PF05279.6 CDI83901.1 - 0.076 12.8 14.3 0.095 12.5 9.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SAPS PF04499.10 CDI83901.1 - 0.089 11.4 16.5 0.1 11.2 11.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GAGA_bind PF06217.7 CDI83901.1 - 0.11 12.3 22.0 0.15 11.9 15.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family NARP1 PF12569.3 CDI83901.1 - 0.14 10.9 23.5 0.18 10.5 16.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF605 PF04652.11 CDI83901.1 - 0.14 11.5 38.8 0.16 11.3 26.9 1.1 1 0 0 1 1 1 0 Vta1 like Arena_glycoprot PF00798.13 CDI83901.1 - 0.22 9.9 11.7 0.26 9.6 8.1 1.0 1 0 0 1 1 1 0 Arenavirus glycoprotein Parvo_coat PF00740.13 CDI83901.1 - 0.32 9.9 27.5 0.35 9.7 19.1 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Ycf1 PF05758.7 CDI83901.1 - 0.32 8.6 20.7 0.39 8.3 14.4 1.1 1 0 0 1 1 1 0 Ycf1 YfhO PF09586.5 CDI83901.1 - 0.36 8.8 10.7 0.43 8.5 7.4 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CRT10 PF08728.5 CDI83901.1 - 0.38 8.6 14.3 0.43 8.5 9.9 1.0 1 0 0 1 1 1 0 CRT10 Cellulose_synt PF03552.9 CDI83901.1 - 0.64 8.2 7.6 0.76 8.0 5.3 1.2 1 0 0 1 1 1 0 Cellulose synthase CDC27 PF09507.5 CDI83901.1 - 0.89 8.7 33.1 1.1 8.3 22.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Adeno_hexon PF01065.14 CDI83901.1 - 0.94 8.2 16.6 1.2 7.9 11.5 1.1 1 0 0 1 1 1 0 Hexon, adenovirus major coat protein, N-terminal domain MRP-S31 PF15433.1 CDI83901.1 - 1 8.7 32.8 1.4 8.2 22.8 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Caldesmon PF02029.10 CDI83901.1 - 1.3 7.3 25.9 1.7 6.9 17.9 1.1 1 0 0 1 1 1 0 Caldesmon DUF1675 PF07897.6 CDI83901.1 - 1.4 8.6 31.3 2 8.2 21.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) DUF342 PF03961.8 CDI83901.1 - 1.6 7.0 13.3 1.9 6.8 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) FemAB PF02388.11 CDI83901.1 - 1.7 7.2 20.3 2.2 6.8 14.1 1.2 1 0 0 1 1 1 0 FemAB family DUF3523 PF12037.3 CDI83901.1 - 2.3 7.1 36.1 3.3 6.6 25.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) DUF3337 PF11816.3 CDI83901.1 - 2.4 7.4 20.8 2.9 7.2 14.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Glyco_transf_6 PF03414.8 CDI83901.1 - 3.1 6.1 12.8 4.5 5.6 8.9 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 6 BTV_NS2 PF04514.7 CDI83901.1 - 4.1 6.1 20.0 5.3 5.8 13.8 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 MarC PF01914.12 CDI83901.1 - 4.2 6.4 11.2 17 4.4 7.8 2.0 1 1 0 1 1 1 0 MarC family integral membrane protein DUF1282 PF06930.7 CDI83901.1 - 5.4 6.6 7.9 21 4.7 5.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) Hid1 PF12722.2 CDI83901.1 - 5.9 4.4 31.2 7.5 4.0 21.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PBP_sp32 PF07222.7 CDI83901.1 - 6.1 5.9 30.5 11 5.0 21.1 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CDC45 PF02724.9 CDI83901.1 - 6.5 4.6 25.9 8.4 4.2 18.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Borrelia_P83 PF05262.6 CDI83901.1 - 7 4.7 24.2 8.4 4.5 16.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein PCEMA1 PF07418.6 CDI83901.1 - 7.6 5.8 14.2 9.5 5.4 9.9 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 AvrE PF11725.3 CDI83901.1 - 8.7 3.2 35.2 9.7 3.0 24.4 1.0 1 0 0 1 1 1 0 Pathogenicity factor DUF3332 PF11810.3 CDI83901.1 - 9 5.9 12.5 16 5.0 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Paramyxo_ncap PF00973.14 CDI83901.1 - 9.7 4.7 21.5 12 4.4 14.9 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2052 PF09747.4 CDI83903.1 - 8.6e-23 81.1 72.3 3e-13 50.0 8.3 4.1 2 1 2 4 4 4 3 Coiled-coil domain containing protein (DUF2052) Totivirus_coat PF05518.6 CDI83905.1 - 4.5 4.9 16.4 7.4 4.2 11.4 1.2 1 0 0 1 1 1 0 Totivirus coat protein TFIIA PF03153.8 CDI83905.1 - 6.5 6.5 16.8 1 9.2 8.2 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit tRNA-synt_2 PF00152.15 CDI83906.1 - 6.6e-38 130.3 0.0 7e-38 130.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 CDI83906.1 - 0.00023 20.4 0.0 0.00037 19.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) MCR_C PF04609.7 CDI83906.1 - 0.096 11.4 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C COX15-CtaA PF02628.10 CDI83907.1 - 1.9e-42 145.1 11.3 1.5e-41 142.2 7.8 1.9 1 1 0 1 1 1 1 Cytochrome oxidase assembly protein DUF2938 PF11158.3 CDI83907.1 - 0.0024 17.2 0.4 0.0024 17.2 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2938) DUF3530 PF12048.3 CDI83907.1 - 0.066 12.1 0.3 0.09 11.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DUF773 PF05600.7 CDI83908.1 - 4e-32 111.6 26.7 1.4e-30 106.6 18.5 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF773) Plasmodium_Vir PF05795.6 CDI83908.1 - 0.042 13.0 0.5 0.062 12.4 0.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF948 PF06103.6 CDI83908.1 - 0.068 13.0 0.9 0.24 11.2 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CotH PF08757.6 CDI83908.1 - 0.17 11.0 3.0 1.7 7.8 0.2 2.8 3 0 0 3 3 3 0 CotH protein DUF3801 PF12687.2 CDI83908.1 - 2.2 7.8 16.4 0.085 12.4 7.2 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3801) EF-hand_1 PF00036.27 CDI83909.1 - 9.1e-29 96.5 13.1 8.5e-09 34.0 1.5 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 CDI83909.1 - 8.7e-27 90.5 6.8 3.1e-06 26.6 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 CDI83909.1 - 2.6e-25 88.3 9.2 2e-12 47.0 2.5 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 CDI83909.1 - 7.4e-21 73.5 9.8 2.8e-14 52.4 1.6 3.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 CDI83909.1 - 2.2e-14 52.0 9.9 2.5e-05 23.3 0.8 4.6 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.1 CDI83909.1 - 8e-13 48.1 0.5 2.5e-06 27.2 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 CDI83909.1 - 1.5e-06 27.8 2.9 0.0052 16.4 0.6 2.5 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand GlnD_UR_UTase PF08335.6 CDI83909.1 - 0.0099 15.7 1.3 1.8 8.4 0.0 2.3 1 1 1 2 2 2 2 GlnD PII-uridylyltransferase UPF0154 PF03672.8 CDI83909.1 - 0.01 15.4 0.2 0.53 9.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) UPF0231 PF06062.6 CDI83909.1 - 0.025 14.4 5.8 0.051 13.4 0.7 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0231) MgtE_N PF03448.12 CDI83909.1 - 0.066 13.5 0.6 0.066 13.5 0.4 2.0 2 1 1 3 3 3 0 MgtE intracellular N domain TerB PF05099.8 CDI83909.1 - 0.092 12.4 3.5 0.32 10.7 0.1 2.6 1 1 3 4 4 4 0 Tellurite resistance protein TerB Ribosomal_L11 PF00298.14 CDI83909.1 - 0.14 12.3 0.2 4.6 7.4 0.0 2.6 1 1 1 2 2 2 0 Ribosomal protein L11, RNA binding domain EF-hand_10 PF14788.1 CDI83909.1 - 0.32 10.7 4.2 0.21 11.2 0.2 2.4 2 0 0 2 2 2 0 EF hand DUF3887 PF13026.1 CDI83909.1 - 0.72 10.1 5.2 0.85 9.9 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3887) Herpes_BLLF1 PF05109.8 CDI83910.1 - 0.0053 14.8 10.0 0.0066 14.4 6.9 1.2 1 0 0 1 1 1 1 Herpes virus major outer envelope glycoprotein (BLLF1) DUF778 PF05608.7 CDI83910.1 - 2.2 8.2 9.4 1.3 8.9 2.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF778) Peptidase_S49_N PF08496.5 CDI83911.1 - 0.39 10.5 8.2 0.67 9.7 5.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PAT1 PF09770.4 CDI83911.1 - 0.39 8.8 40.5 0.46 8.6 28.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.9 CDI83911.1 - 0.88 7.5 20.3 0.0077 14.3 4.0 2.1 2 0 0 2 2 2 0 CDC45-like protein HemX PF04375.9 CDI83911.1 - 1.5 7.3 32.8 2.3 6.7 22.7 1.2 1 0 0 1 1 1 0 HemX DUF2232 PF09991.4 CDI83911.1 - 1.9 7.4 3.8 2.4 7.0 2.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DNA_pol3_a_NII PF11490.3 CDI83911.1 - 2.3 7.8 23.4 5.2 6.7 16.2 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Pkinase PF00069.20 CDI83914.1 - 8.9e-38 129.9 0.0 8.9e-38 129.9 0.0 2.7 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83914.1 - 1.1e-34 119.6 0.0 1.1e-34 119.6 0.0 2.9 3 0 0 3 3 3 1 Protein tyrosine kinase IncA PF04156.9 CDI83915.1 - 1.9e-05 24.3 12.0 1.9e-05 24.3 8.3 3.1 3 0 0 3 3 3 1 IncA protein DUF4207 PF13904.1 CDI83915.1 - 0.011 15.1 12.0 0.011 15.1 8.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4207) Spt20 PF12090.3 CDI83915.1 - 0.084 12.2 11.2 0.053 12.8 2.9 2.4 2 0 0 2 2 2 0 Spt20 family Herpes_glycop PF01528.11 CDI83915.1 - 0.82 8.2 3.7 1.7 7.2 2.6 1.4 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Serinc PF03348.10 CDI83915.1 - 0.85 8.2 17.0 0.0094 14.7 2.4 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) Suf PF05843.9 CDI83915.1 - 2.4 7.7 17.2 0.12 12.1 4.7 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DDHD PF02862.12 CDI83915.1 - 8.4 6.1 18.9 3.2 7.5 2.9 2.3 2 0 0 2 2 2 0 DDHD domain Fcf1 PF04900.7 CDI83916.1 - 5.9e-16 58.3 0.0 7.1e-11 42.0 0.0 4.2 5 0 0 5 5 5 2 Fcf1 DSPc PF00782.15 CDI83916.1 - 1.6e-05 24.5 0.1 7.1e-05 22.4 0.1 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 CDI83916.1 - 3.6e-05 24.0 0.3 3.6e-05 24.0 0.2 4.0 5 1 0 5 5 5 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.8 CDI83916.1 - 0.072 12.4 0.0 0.21 10.9 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family MORN PF02493.15 CDI83917.1 - 1e-45 150.7 63.5 2.5e-07 30.0 1.0 9.8 10 0 0 10 10 10 9 MORN repeat BAF1_ABF1 PF04684.8 CDI83917.1 - 7.6e-05 21.7 7.6 0.00012 21.0 5.3 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor FCP1_C PF09309.5 CDI83917.1 - 0.00031 20.1 9.2 0.00045 19.6 6.4 1.2 1 0 0 1 1 1 1 FCP1, C-terminal YjgP_YjgQ PF03739.9 CDI83917.1 - 0.02 13.6 0.4 0.03 13.0 0.3 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Neur_chan_memb PF02932.11 CDI83917.1 - 0.97 9.2 3.0 1.2 8.9 2.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spore_coat_CotO PF14153.1 CDI83917.1 - 7.2 6.0 18.0 11 5.3 12.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Ycf1 PF05758.7 CDI83917.1 - 7.9 4.0 10.3 9.9 3.7 7.1 1.0 1 0 0 1 1 1 0 Ycf1 Paf1 PF03985.8 CDI83917.1 - 8.5 4.9 16.9 14 4.3 11.7 1.3 1 0 0 1 1 1 0 Paf1 Dicty_REP PF05086.7 CDI83917.1 - 8.9 3.9 6.9 12 3.5 4.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hid1 PF12722.2 CDI83917.1 - 9.3 3.7 11.8 12 3.4 8.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HD_3 PF13023.1 CDI83918.1 - 6.2e-26 91.0 0.2 7.2e-26 90.8 0.2 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 CDI83918.1 - 0.0015 18.5 0.1 0.0038 17.2 0.1 1.7 1 1 0 1 1 1 1 HD domain PRONE PF03759.8 CDI83918.1 - 0.034 12.7 0.0 0.034 12.7 0.0 1.1 1 0 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) ABC1 PF03109.11 CDI83920.1 - 6.6e-29 100.2 0.0 1.4e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 ABC1 family RskA PF10099.4 CDI83920.1 - 0.0091 15.7 1.5 0.0091 15.7 1.0 8.3 8 1 0 8 8 8 3 Anti-sigma-K factor rskA DUF2512 PF10710.4 CDI83920.1 - 1.8 8.0 3.4 1.8 8.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) Pex2_Pex12 PF04757.9 CDI83922.1 - 1e-07 31.6 2.1 1.3e-07 31.2 0.1 2.2 3 1 0 3 3 3 1 Pex2 / Pex12 amino terminal region DUF947 PF06102.7 CDI83923.1 - 6e-23 81.5 19.7 6e-23 81.5 13.7 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF947) DUF1207 PF06727.6 CDI83923.1 - 6.3 5.5 9.6 0.49 9.1 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1207) MT-A70 PF05063.9 CDI83926.1 - 4e-15 55.8 0.0 1.5e-11 44.1 0.0 3.0 1 1 1 2 2 2 2 MT-A70 RRM_1 PF00076.17 CDI83927.1 - 3.5e-16 58.6 0.0 4.3e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI83927.1 - 3.2e-14 52.6 0.0 4.1e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI83927.1 - 1e-13 50.8 0.0 1.3e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Otopetrin PF03189.8 CDI83928.1 - 0.37 9.7 2.9 0.93 8.4 2.0 1.6 1 0 0 1 1 1 0 Otopetrin DUF3953 PF13129.1 CDI83928.1 - 3.8 7.2 1.6 8.7 6.0 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) Nop53 PF07767.6 CDI83929.1 - 6.6e-14 51.7 39.0 1.6e-07 30.6 16.8 2.1 1 1 1 2 2 2 2 Nop53 (60S ribosomal biogenesis) DUF2291 PF10054.4 CDI83929.1 - 1.8 7.7 8.5 0.067 12.4 1.3 1.9 2 0 0 2 2 2 0 Predicted periplasmic lipoprotein (DUF2291) Shadoo PF14999.1 CDI83929.1 - 2 8.2 12.3 4.2 7.2 3.5 3.1 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective RAP PF08373.5 CDI83930.1 - 4e-05 23.3 7.6 0.00041 20.0 0.0 2.9 3 0 0 3 3 3 2 RAP domain AAA_23 PF13476.1 CDI83930.1 - 0.018 15.4 3.8 0.66 10.2 0.1 2.7 2 1 0 2 2 2 0 AAA domain EphA2_TM PF14575.1 CDI83930.1 - 7.1 7.0 7.2 1.4 9.3 0.9 2.8 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain 6PGD PF00393.14 CDI83931.1 - 3e-47 161.2 0.1 6.4e-47 160.1 0.1 1.6 2 0 0 2 2 2 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 CDI83931.1 - 6e-44 149.7 0.0 9.1e-44 149.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 CDI83931.1 - 0.012 15.2 0.1 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.1 CDI83931.1 - 0.074 13.1 0.5 10 6.1 0.0 2.6 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase AAA PF00004.24 CDI83932.1 - 6.4e-36 123.4 0.0 2.5e-35 121.5 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDI83932.1 - 2.2e-07 30.1 0.0 2.2e-07 30.1 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CDI83932.1 - 0.00064 20.5 0.0 0.0014 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDI83932.1 - 0.0011 19.2 0.0 0.0042 17.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain NUDIX PF00293.23 CDI83932.1 - 0.0017 17.9 0.0 0.005 16.4 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain AAA_14 PF13173.1 CDI83932.1 - 0.0018 18.1 0.1 0.0063 16.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 CDI83932.1 - 0.0039 15.9 0.0 0.0093 14.7 0.0 1.6 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 CDI83932.1 - 0.0042 16.9 0.0 0.0042 16.9 0.0 4.6 4 2 1 5 5 3 1 AAA domain AAA_5 PF07728.9 CDI83932.1 - 0.0066 16.1 0.1 0.047 13.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDI83932.1 - 0.0099 16.0 0.9 0.0099 16.0 0.6 4.0 3 2 1 4 4 4 1 AAA domain AAA_25 PF13481.1 CDI83932.1 - 0.01 15.2 6.3 0.091 12.1 0.4 3.1 2 1 1 3 3 3 0 AAA domain AAA_2 PF07724.9 CDI83932.1 - 0.015 15.1 0.0 0.015 15.1 0.0 3.1 3 0 0 3 3 2 0 AAA domain (Cdc48 subfamily) PEPCK_ATP PF01293.15 CDI83932.1 - 0.023 13.2 0.0 0.045 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA_19 PF13245.1 CDI83932.1 - 0.065 12.9 0.1 0.065 12.9 0.0 3.1 5 0 0 5 5 2 0 Part of AAA domain SKI PF01202.17 CDI83932.1 - 0.25 11.2 0.0 0.25 11.2 0.0 4.1 3 1 0 4 4 4 0 Shikimate kinase AAA_28 PF13521.1 CDI83932.1 - 0.36 10.7 0.0 0.36 10.7 0.0 4.8 6 1 0 6 6 4 0 AAA domain Flavodoxin_1 PF00258.20 CDI83934.1 - 2.2e-19 69.8 0.3 9.2e-16 58.1 0.0 3.3 2 0 0 2 2 2 2 Flavodoxin FAD_binding_1 PF00667.15 CDI83934.1 - 1.1e-10 41.3 2.3 0.0007 19.1 0.0 4.8 4 1 0 4 4 4 3 FAD binding domain NAD_binding_1 PF00175.16 CDI83934.1 - 1.5e-07 31.9 5.2 5.4e-05 23.7 0.0 3.7 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain Folate_carrier PF01770.13 CDI83934.1 - 9.4 4.6 12.3 0.16 10.4 2.5 2.4 3 0 0 3 3 3 0 Reduced folate carrier Amidase PF01425.16 CDI83936.1 - 0.0046 15.8 11.2 0.0061 15.4 0.2 2.9 3 0 0 3 3 3 2 Amidase Guanylate_cyc PF00211.15 CDI83937.1 - 6.6e-35 120.1 0.0 7.4e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Flavoprotein PF02441.14 CDI83940.1 - 7.7e-11 41.7 0.1 3.1e-10 39.8 0.0 1.8 2 0 0 2 2 2 1 Flavoprotein Phostensin_N PF13916.1 CDI83940.1 - 0.18 11.7 2.6 0.38 10.7 1.8 1.6 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal CorA PF01544.13 CDI83942.1 - 0.0055 15.7 1.7 0.014 14.4 1.2 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein TFIIA PF03153.8 CDI83942.1 - 0.013 15.4 31.7 0.027 14.3 12.9 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF1681 PF07933.9 CDI83942.1 - 1.3 8.5 5.3 0.44 10.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1681) Shadoo PF14999.1 CDI83943.1 - 0.0054 16.5 18.7 0.79 9.5 2.3 3.4 3 0 0 3 3 3 3 Shadow of prion protein, neuroprotective zf-RING_2 PF13639.1 CDI83944.1 - 1.6e-09 37.4 8.6 3.3e-09 36.4 6.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDI83944.1 - 6.5e-08 32.4 10.2 1.3e-07 31.5 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDI83944.1 - 2.6e-07 30.1 9.7 5.7e-07 29.0 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI83944.1 - 2.8e-07 30.1 6.8 5.6e-07 29.1 4.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CDI83944.1 - 4.6e-07 29.4 10.1 8.9e-07 28.4 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) LON PF02190.11 CDI83944.1 - 1.4e-05 24.8 0.0 3.3e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 ATP-dependent protease La (LON) domain zf-C3HC4_4 PF15227.1 CDI83944.1 - 2.3e-05 24.1 11.2 5.6e-05 22.9 7.7 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING U-box PF04564.10 CDI83944.1 - 3.3e-05 23.7 0.2 7.4e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 U-box domain zf-rbx1 PF12678.2 CDI83944.1 - 0.0034 17.4 4.0 0.0034 17.4 2.8 2.0 2 1 0 2 2 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 CDI83944.1 - 0.0052 16.4 7.0 0.014 15.1 4.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.1 CDI83944.1 - 0.011 15.2 3.4 0.027 14.0 2.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.1 CDI83944.1 - 0.014 15.1 6.5 0.032 14.0 4.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.1 CDI83944.1 - 0.37 10.3 7.1 1 8.9 4.9 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Pex14_N PF04695.8 CDI83944.1 - 8 6.5 19.1 1 9.4 3.7 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TPR_2 PF07719.12 CDI83946.1 - 2.1e-17 61.5 16.5 5.3e-06 25.9 0.1 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 CDI83946.1 - 8.4e-17 61.3 25.0 1.1e-05 25.9 1.1 4.3 2 1 1 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 CDI83946.1 - 4.4e-15 55.0 17.1 4.2e-06 26.2 1.8 4.6 1 1 3 5 5 5 4 TPR repeat TPR_1 PF00515.23 CDI83946.1 - 1.7e-14 52.6 6.2 3e-05 23.4 0.1 4.8 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 CDI83946.1 - 2.6e-13 49.7 5.8 9.2e-06 25.5 0.2 4.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 CDI83946.1 - 4.3e-09 35.4 0.1 0.024 14.4 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDI83946.1 - 7.7e-09 35.7 25.2 4.7e-05 23.6 2.0 4.8 3 2 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDI83946.1 - 1.4e-08 34.6 27.1 0.0077 16.7 0.1 6.4 1 1 6 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.1 CDI83946.1 - 3.7e-07 29.4 4.8 0.01 15.5 0.0 4.7 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.1 CDI83946.1 - 9.9e-06 24.8 2.6 9.9e-06 24.8 1.8 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI83946.1 - 4.8e-05 23.2 10.3 0.025 14.7 0.1 6.0 5 2 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 CDI83946.1 - 0.0008 19.4 6.9 0.89 9.7 0.2 3.3 1 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.4 CDI83946.1 - 0.022 14.6 8.1 1.4 8.8 2.7 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 CDI83946.1 - 0.039 13.8 20.2 0.087 12.6 0.2 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 CDI83946.1 - 0.051 13.5 0.3 0.051 13.5 0.2 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat NARP1 PF12569.3 CDI83946.1 - 0.064 12.0 1.3 0.22 10.2 0.3 2.1 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 TPR_3 PF07720.7 CDI83946.1 - 0.071 12.9 2.9 0.7 9.7 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDI83946.1 - 0.65 10.5 12.5 4 8.1 0.1 5.7 7 0 0 7 7 6 0 Tetratricopeptide repeat BTAD PF03704.12 CDI83946.1 - 1.3 9.2 16.2 0.2 11.9 0.3 3.8 2 1 1 3 3 3 0 Bacterial transcriptional activator domain HA2 PF04408.18 CDI83947.1 - 0.79 9.7 3.2 0.8 9.7 2.2 1.0 1 0 0 1 1 1 0 Helicase associated domain (HA2) FAM176 PF14851.1 CDI83947.1 - 1.6 8.3 6.9 1.5 8.4 4.8 1.0 1 0 0 1 1 1 0 FAM176 family Peptidase_S49_N PF08496.5 CDI83947.1 - 4.2 7.1 9.8 4 7.2 6.8 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF912 PF06024.7 CDI83947.1 - 4.7 7.3 7.4 4.5 7.3 5.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-DHHC PF01529.15 CDI83947.1 - 7.1 5.9 8.5 6.8 6.0 5.9 1.0 1 0 0 1 1 1 0 DHHC palmitoyltransferase EphA2_TM PF14575.1 CDI83947.1 - 7.3 7.0 6.6 8 6.9 4.6 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF775 PF05603.7 CDI83947.1 - 8.8 5.7 13.6 8.7 5.8 9.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF775) EIIBC-GUT_N PF03612.9 CDI83947.1 - 9.3 5.8 8.4 8.8 5.9 5.8 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus eIF_4EBP PF05456.6 CDI83947.1 - 9.4 5.9 9.2 9.2 5.9 6.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DDHD PF02862.12 CDI83947.1 - 9.8 5.8 9.2 9.5 5.9 6.4 1.0 1 0 0 1 1 1 0 DDHD domain Methyltrn_RNA_3 PF02598.12 CDI83948.1 - 4.5e-18 65.6 0.0 2.1e-05 24.0 0.0 3.1 3 0 0 3 3 3 3 Putative RNA methyltransferase AdoHcyase PF05221.12 CDI83949.1 - 2.2e-88 295.6 1.0 1.8e-72 243.5 0.2 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase TMEM107 PF14995.1 CDI83949.1 - 0.0019 18.3 0.0 0.003 17.6 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein Collagen PF01391.13 CDI83950.1 - 8e-05 22.1 19.8 0.00021 20.7 13.7 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TATR PF03430.8 CDI83950.1 - 0.36 9.4 3.0 0.63 8.6 2.1 1.5 1 0 0 1 1 1 0 Trans-activating transcriptional regulator LcrG PF07216.7 CDI83951.1 - 9.6 6.3 9.9 0.093 12.7 0.4 2.4 2 1 0 2 2 2 0 LcrG protein TSP_1 PF00090.14 CDI83952.1 - 1.2e-05 25.3 7.6 1.2e-05 25.3 5.3 2.7 3 0 0 3 3 3 1 Thrombospondin type 1 domain CAP PF00188.21 CDI83952.1 - 2.6e-05 24.7 0.2 6.7e-05 23.3 0.1 1.8 1 1 0 1 1 1 1 Cysteine-rich secretory protein family CLTH PF10607.4 CDI83953.1 - 0.089 12.4 0.2 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain IncA PF04156.9 CDI83953.1 - 9.1 5.8 14.3 0.58 9.7 1.7 2.2 2 0 0 2 2 2 0 IncA protein p25-alpha PF05517.7 CDI83954.1 - 5.2e-39 133.9 1.5 5.8e-39 133.8 1.1 1.0 1 0 0 1 1 1 1 p25-alpha SurA_N PF09312.6 CDI83954.1 - 0.14 11.9 0.1 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 SurA N-terminal domain SET PF00856.23 CDI83955.1 - 8.1e-12 45.7 0.0 8.5e-10 39.1 0.2 2.6 2 1 0 2 2 2 2 SET domain DUF367 PF04034.8 CDI83956.1 - 1.4e-35 121.6 0.0 2.5e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 CDI83956.1 - 0.0027 17.2 0.1 0.005 16.3 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI DUF4349 PF14257.1 CDI83957.1 - 0.25 10.5 3.7 0.3 10.2 2.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF3761 PF12587.3 CDI83957.1 - 0.4 10.8 5.3 0.49 10.5 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) Dsh_C PF12316.3 CDI83957.1 - 1.5 8.9 18.8 1.7 8.6 13.0 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Sporozoite_P67 PF05642.6 CDI83957.1 - 2.8 5.6 14.6 3.2 5.4 10.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Binary_toxB PF03495.9 CDI83957.1 - 5.5 5.5 18.7 6.6 5.2 12.9 1.0 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA Dsh_C PF12316.3 CDI83961.1 - 1.6 8.8 15.7 1.8 8.6 10.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CytochromB561_N PF09786.4 CDI83961.1 - 5.1 5.4 17.6 6.5 5.0 12.2 1.3 1 1 0 1 1 1 0 Cytochrome B561, N terminal DnaJ PF00226.26 CDI83962.1 - 0.00052 19.6 0.1 0.00052 19.6 0.1 3.0 3 0 0 3 3 3 1 DnaJ domain Miff PF05644.6 CDI83962.1 - 1.6 8.2 21.6 0.39 10.3 1.8 3.8 4 0 0 4 4 4 0 Mitochondrial and peroxisomal fission factor Mff AAA PF00004.24 CDI83963.1 - 1.3e-05 25.3 8.4 0.04 14.1 0.0 5.3 4 2 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) DUF4367 PF14285.1 CDI83963.1 - 2.4 7.4 4.8 10 5.3 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4367) zf-HC5HC2H_2 PF13832.1 CDI83964.1 - 1.6e-12 47.4 13.5 9.7e-08 31.9 0.1 3.3 3 0 0 3 3 3 2 PHD-zinc-finger like domain PHD_2 PF13831.1 CDI83964.1 - 2.5e-11 42.6 1.8 2.5e-11 42.6 1.2 3.5 4 0 0 4 4 4 1 PHD-finger PHD PF00628.24 CDI83964.1 - 2.2e-09 36.8 5.0 2.2e-09 36.8 3.4 3.2 3 1 0 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.1 CDI83964.1 - 4.3e-06 26.7 15.8 3.7e-05 23.7 2.7 4.2 4 0 0 4 4 4 1 PHD-like zinc-binding domain C1_1 PF00130.17 CDI83964.1 - 0.00039 20.0 0.1 0.00039 20.0 0.1 3.0 4 0 0 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 CDI83964.1 - 0.0099 15.5 2.1 0.0099 15.5 1.5 2.5 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 hDGE_amylase PF14701.1 CDI83965.1 - 2e-105 353.1 0.0 6.7e-59 199.8 0.0 3.6 1 1 1 3 3 3 3 glucanotransferase domain of human glycogen debranching enzyme hGDE_central PF14702.1 CDI83965.1 - 9e-29 100.4 0.0 2.7e-28 98.8 0.0 1.8 1 1 0 1 1 1 1 central domain of human glycogen debranching enzyme GDE_C PF06202.9 CDI83965.1 - 6.2e-07 28.4 0.1 9.9e-07 27.7 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase DUF473 PF04322.7 CDI83965.1 - 0.054 13.1 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF473) AF-4 PF05110.8 CDI83965.1 - 2.8 5.7 5.4 5.8 4.6 3.8 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF2228 PF10228.4 CDI83966.1 - 1.2e-16 61.0 3.5 8.7e-14 51.6 0.0 3.5 4 0 0 4 4 4 2 Uncharacterised conserved protein (DUF2228) Tim54 PF11711.3 CDI83966.1 - 0.53 8.8 10.0 0.012 14.1 1.7 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Gti1_Pac2 PF09729.4 CDI83966.1 - 9.6 6.0 20.6 0.54 10.1 3.2 3.4 3 0 0 3 3 3 0 Gti1/Pac2 family DUF3546 PF12066.3 CDI83967.1 - 1.5e-13 50.6 0.1 2.5e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) NARP1 PF12569.3 CDI83968.1 - 7.4e-14 51.3 3.0 9.5e-14 51.0 0.1 2.1 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 LCCL PF03815.14 CDI83968.1 - 1.5e-13 50.5 3.4 2e-13 50.0 0.1 2.7 3 0 0 3 3 2 1 LCCL domain F5_F8_type_C PF00754.20 CDI83968.1 - 7.3e-12 45.2 0.0 1.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain TPR_2 PF07719.12 CDI83968.1 - 3.4e-09 35.9 8.4 1.3e-05 24.6 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDI83968.1 - 3.9e-08 32.8 7.8 7.5e-05 22.3 0.1 4.4 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.23 CDI83968.1 - 1.2e-06 27.8 1.9 0.00013 21.3 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDI83968.1 - 1.9e-06 28.4 4.9 0.0027 18.3 0.5 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDI83968.1 - 2.2e-05 23.8 1.2 0.011 15.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDI83968.1 - 0.00024 21.3 6.3 0.078 13.3 0.1 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDI83968.1 - 0.0003 21.1 6.9 0.24 12.1 0.1 5.0 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI83968.1 - 0.0012 18.8 1.5 15 6.0 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat Glyco_hydro_65m PF03632.10 CDI83968.1 - 0.0015 17.2 0.1 0.0028 16.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain TPR_12 PF13424.1 CDI83968.1 - 0.0069 16.3 0.7 0.12 12.3 0.1 3.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDI83968.1 - 0.0094 15.6 0.6 0.2 11.5 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDI83968.1 - 0.02 15.3 4.3 16 6.2 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF1080 PF06439.6 CDI83968.1 - 0.077 12.8 0.0 0.24 11.2 0.0 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1080) RNA_pol_3_Rpc31 PF11705.3 CDI83969.1 - 4e-05 23.6 21.3 0.0024 17.8 14.7 2.2 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.5 CDI83969.1 - 0.015 15.8 5.8 0.028 14.9 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) IF-2B PF01008.12 CDI83970.1 - 9.4e-10 37.9 2.7 2e-09 36.8 1.9 1.5 1 0 0 1 1 1 1 Initiation factor 2 subunit family SPX PF03105.14 CDI83970.1 - 0.53 10.0 22.7 0.016 15.0 2.1 2.2 2 0 0 2 2 2 0 SPX domain Utp14 PF04615.8 CDI83970.1 - 1.8 6.6 19.9 2.8 5.9 13.8 1.2 1 0 0 1 1 1 0 Utp14 protein DUF936 PF06075.7 CDI83970.1 - 2.1 7.1 31.6 2.8 6.7 21.9 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Mem_trans PF03547.13 CDI83970.1 - 2.2 6.5 18.2 0.086 11.1 2.5 2.1 2 0 0 2 2 2 0 Membrane transport protein Med7 PF05983.6 CDI83971.1 - 3.4 7.4 7.4 8 6.2 5.2 1.6 1 0 0 1 1 1 0 MED7 protein Pkinase PF00069.20 CDI83972.1 - 7.8e-24 84.2 0.1 5.6e-13 48.6 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI83972.1 - 3e-12 46.1 0.1 4.3e-05 22.7 0.1 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase DREPP PF05558.7 CDI83973.1 - 1.1 9.0 18.0 1.2 8.9 12.5 1.0 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Mcm10 PF09332.6 CDI83974.1 - 3.2e-12 46.4 20.0 3.2e-12 46.4 13.9 3.5 1 1 1 3 3 3 1 Mcm10 replication factor zf-primase PF09329.6 CDI83974.1 - 8.1e-07 28.5 0.2 1.8e-06 27.4 0.2 1.6 1 0 0 1 1 1 1 Primase zinc finger DUF1967 PF09269.6 CDI83974.1 - 0.064 12.9 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) Ndc80_HEC PF03801.8 CDI83975.1 - 1.8e-29 102.2 0.0 1.8e-29 102.2 0.0 2.6 2 0 0 2 2 2 1 HEC/Ndc80p family DUF2638 PF10937.3 CDI83975.1 - 6.4 7.8 7.6 1.7 9.6 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2638) Serglycin PF04360.7 CDI83978.1 - 0.0059 16.3 5.1 0.0059 16.3 3.6 6.5 4 2 0 4 4 4 1 Serglycin DUF3792 PF12670.2 CDI83979.1 - 0.054 13.3 0.5 0.094 12.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) PROCN PF08083.6 CDI83980.1 - 2.5e-218 724.4 4.5 4.1e-218 723.7 3.1 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 CDI83980.1 - 5.9e-124 411.8 1.4 9.4e-124 411.2 0.9 1.3 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 CDI83980.1 - 1.6e-92 307.1 1.3 2.9e-92 306.2 0.9 1.5 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 CDI83980.1 - 1.1e-78 262.1 0.7 2.6e-78 260.9 0.5 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 CDI83980.1 - 2.5e-67 224.6 0.1 5e-67 223.6 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.6 CDI83980.1 - 3.2e-47 159.3 0.0 7e-47 158.2 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.4 CDI83980.1 - 3.1e-43 145.5 0.1 8.1e-43 144.2 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.16 CDI83980.1 - 0.0035 17.0 0.0 0.013 15.2 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease zf-CW PF07496.10 CDI83983.1 - 2.2e-15 56.0 4.8 6e-15 54.6 3.4 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger WD40 PF00400.27 CDI83983.1 - 0.00029 20.6 7.6 0.021 14.6 0.1 5.8 5 1 0 5 5 5 1 WD domain, G-beta repeat SR-25 PF10500.4 CDI83983.1 - 0.0012 18.3 14.0 0.0012 18.3 9.7 16.2 12 4 2 16 16 16 3 Nuclear RNA-splicing-associated protein DDHD PF02862.12 CDI83984.1 - 0.13 12.0 12.7 0.062 13.0 1.8 2.3 2 0 0 2 2 2 0 DDHD domain FimP PF09766.4 CDI83984.1 - 0.76 8.7 13.0 1.8 7.5 1.5 2.4 2 0 0 2 2 2 0 Fms-interacting protein Spt20 PF12090.3 CDI83984.1 - 2.2 7.6 14.0 0.52 9.6 0.3 2.6 3 0 0 3 3 3 0 Spt20 family Pap_E4 PF02711.9 CDI83984.1 - 7 7.5 15.4 0.78 10.5 1.7 4.0 4 0 0 4 4 4 0 E4 protein MPC PF03650.8 CDI83985.1 - 2.8e-27 95.0 0.3 4.5e-27 94.3 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) LSM PF01423.17 CDI83986.1 - 1.3e-18 66.2 0.0 1.6e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain Pkinase PF00069.20 CDI83987.1 - 1.3e-38 132.6 0.0 1.5e-27 96.3 0.0 4.7 6 1 0 6 6 6 2 Protein kinase domain Glycolytic PF00274.14 CDI83988.1 - 2.1e-168 559.1 0.0 2.4e-168 558.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I HHH PF00633.18 CDI83989.1 - 0.00011 21.7 0.0 0.00023 20.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Rad10 PF03834.9 CDI83989.1 - 0.0025 17.4 3.3 0.011 15.4 0.8 2.3 1 1 1 2 2 2 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) FimP PF09766.4 CDI83989.1 - 0.008 15.2 12.1 0.017 14.1 8.4 1.6 1 0 0 1 1 1 1 Fms-interacting protein HHH_2 PF12826.2 CDI83989.1 - 0.015 15.1 0.0 0.042 13.7 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Met_synt_B12 PF02965.12 CDI83989.1 - 0.028 13.6 1.8 0.039 13.1 0.2 1.9 1 1 1 2 2 2 0 Vitamin B12 dependent methionine synthase, activation domain OmpH PF03938.9 CDI83989.1 - 0.037 13.9 19.6 4.6 7.1 13.6 2.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Pap_E4 PF02711.9 CDI83989.1 - 1.4 9.7 11.6 3.7 8.4 8.1 1.8 1 0 0 1 1 1 0 E4 protein Glyco_transf_15 PF01793.11 CDI83989.1 - 1.7 7.5 5.3 3 6.6 3.7 1.4 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase PIH1 PF08190.7 CDI83989.1 - 2.3 7.6 13.8 3.8 6.8 9.6 1.3 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 TraV PF09676.5 CDI83989.1 - 3.6 8.3 12.1 0.24 12.1 3.7 2.2 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Pex16 PF08610.5 CDI83989.1 - 7.5 5.4 9.6 11 4.8 6.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) XRN_N PF03159.13 CDI83989.1 - 7.6 5.8 7.5 15 4.8 5.2 1.4 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Thioredoxin PF00085.15 CDI83990.1 - 0.00021 20.9 0.0 0.00032 20.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.1 CDI83990.1 - 0.0027 17.5 0.0 0.0036 17.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Lambda_Bor PF06291.6 CDI83991.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 1 0 1 1 1 0 Bor protein ketoacyl-synt PF00109.21 CDI83992.1 - 1.4e-84 283.5 0.6 3.3e-84 282.3 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.23 CDI83992.1 - 5.8e-72 242.3 0.0 2.5e-71 240.2 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme PS-DH PF14765.1 CDI83992.1 - 6.3e-45 153.5 0.0 1.2e-32 113.2 0.0 2.4 2 0 0 2 2 2 2 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 CDI83992.1 - 1.7e-42 143.9 0.0 4.3e-42 142.7 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.16 CDI83992.1 - 1.9e-27 96.4 0.0 3.7e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ADH_zinc_N PF00107.21 CDI83992.1 - 4.2e-15 55.4 0.0 1.2e-14 53.9 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.20 CDI83992.1 - 1.4e-10 41.2 0.3 3.9e-10 39.8 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.7 CDI83992.1 - 4.4e-08 32.8 0.4 4e-07 29.7 0.0 2.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 CDI83992.1 - 1.2e-06 29.4 0.0 7.9e-06 26.7 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Thiolase_N PF00108.18 CDI83992.1 - 3.5e-05 22.9 1.7 6.4e-05 22.0 0.1 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain AMP-binding_C_2 PF14535.1 CDI83992.1 - 0.0025 17.8 0.0 0.0074 16.3 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TRAPPC-Trs85 PF12739.2 CDI83996.1 - 2.6e-48 164.7 31.3 5.4e-48 163.6 18.1 4.1 2 1 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit LRR_4 PF12799.2 CDI83997.1 - 2.5e-17 62.0 9.3 1.9e-06 27.3 0.0 3.8 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDI83997.1 - 1.6e-13 50.1 14.1 5.7e-08 32.4 1.6 3.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 CDI83997.1 - 1.9e-09 36.2 13.0 0.004 16.9 0.3 6.5 5 1 1 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.1 CDI83997.1 - 5.9e-07 28.8 13.6 0.74 10.0 0.1 6.4 6 0 0 6 6 6 4 Leucine Rich repeat LRR_7 PF13504.1 CDI83997.1 - 7.7e-06 25.2 13.9 0.047 13.8 0.1 6.2 4 1 1 5 5 5 3 Leucine rich repeat LRR_9 PF14580.1 CDI83997.1 - 0.6 9.6 3.2 2.7 7.5 0.4 2.5 1 1 1 2 2 2 0 Leucine-rich repeat Peptidase_C54 PF03416.14 CDI83998.1 - 5.5e-20 71.6 3.0 2.1e-09 36.9 0.0 4.4 4 0 0 4 4 4 3 Peptidase family C54 SR-25 PF10500.4 CDI83998.1 - 0.0024 17.3 6.5 0.0024 17.3 4.5 28.3 19 9 6 26 26 26 5 Nuclear RNA-splicing-associated protein DUF2615 PF11027.3 CDI83999.1 - 2.2 8.2 8.4 0.46 10.4 0.1 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF2615) OATP PF03137.15 CDI84001.1 - 0.0085 14.1 2.4 0.3 9.0 0.0 2.1 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Ycf1 PF05758.7 CDI84001.1 - 0.59 7.7 5.6 2.9 5.4 0.0 2.0 2 0 0 2 2 2 0 Ycf1 DDHD PF02862.12 CDI84001.1 - 1.6 8.4 10.0 1.9 8.2 0.2 2.2 2 0 0 2 2 2 0 DDHD domain DUF4557 PF15101.1 CDI84001.1 - 8.6 6.1 19.1 2.4 7.9 6.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Med15 PF09606.5 CDI84002.1 - 0.00015 20.1 32.9 0.00015 20.1 22.8 3.7 3 1 0 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal Lipoprotein_10 PF03202.8 CDI84003.1 - 1 9.3 8.1 0.05 13.6 0.8 2.0 2 0 0 2 2 2 0 Putative mycoplasma lipoprotein, C-terminal region SR-25 PF10500.4 CDI84007.1 - 0.0033 16.9 9.4 0.0065 15.9 6.5 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein FR47 PF08445.5 CDI84007.1 - 0.015 15.0 0.1 0.038 13.7 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein DUF3749 PF12568.3 CDI84007.1 - 0.022 14.3 5.2 0.055 13.0 3.6 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RNA_pol_Rpc4 PF05132.9 CDI84007.1 - 0.095 12.6 2.0 0.33 10.9 1.4 1.9 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop53 PF07767.6 CDI84007.1 - 0.25 10.3 15.2 0.43 9.5 10.5 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Suf PF05843.9 CDI84007.1 - 0.31 10.7 9.0 0.49 10.0 6.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.3 CDI84007.1 - 0.64 9.3 3.6 0.94 8.8 2.5 1.3 1 0 0 1 1 1 0 Spt20 family FemAB PF02388.11 CDI84007.1 - 0.68 8.5 6.0 1.2 7.7 4.1 1.3 1 0 0 1 1 1 0 FemAB family Pap_E4 PF02711.9 CDI84007.1 - 1.2 9.9 5.6 2.8 8.8 3.9 1.5 1 0 0 1 1 1 0 E4 protein FLO_LFY PF01698.11 CDI84007.1 - 1.6 7.5 10.8 2.9 6.6 7.5 1.4 1 0 0 1 1 1 0 Floricaula / Leafy protein FAM176 PF14851.1 CDI84007.1 - 2.7 7.6 6.6 0.24 11.0 0.9 2.0 2 0 0 2 2 2 0 FAM176 family Hex_IIIa PF02455.11 CDI84007.1 - 2.9 6.4 9.1 5.4 5.5 6.3 1.4 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) PHD_3 PF13922.1 CDI84007.1 - 3.1 8.1 14.9 0.51 10.6 6.1 2.9 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx Hid1 PF12722.2 CDI84007.1 - 3.3 5.2 4.7 4.3 4.9 3.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAGA-Tad1 PF12767.2 CDI84007.1 - 3.7 7.1 14.1 2 8.0 8.1 1.7 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit XRCC4 PF06632.7 CDI84007.1 - 5.5 5.7 9.9 8.8 5.0 6.9 1.3 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Ycf1 PF05758.7 CDI84007.1 - 5.7 4.5 5.7 7.5 4.1 3.9 1.1 1 0 0 1 1 1 0 Ycf1 ATP-synt_C PF00137.16 CDI84008.1 - 2.6e-29 100.9 32.5 1.9e-16 59.7 8.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2592 PF10766.4 CDI84008.1 - 4.6 6.6 9.6 0.45 9.8 2.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2592) Mtc PF03820.12 CDI84009.1 - 1.4e-10 40.3 1.6 2.1e-10 39.7 1.1 1.3 1 0 0 1 1 1 1 Tricarboxylate carrier DUF3685 PF12452.3 CDI84009.1 - 0.034 13.2 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) AhpC-TSA PF00578.16 CDI84011.1 - 3.2e-37 126.9 0.0 4e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CDI84011.1 - 6.5e-18 64.6 0.0 7.6e-18 64.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 CDI84011.1 - 7.8e-14 51.0 0.1 1.6e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DUF4200 PF13863.1 CDI84012.1 - 4.4e-18 65.4 14.7 4.4e-18 65.4 10.2 3.6 2 1 1 3 3 3 1 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.7 CDI84012.1 - 1.2 8.9 5.2 14 5.4 0.2 2.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PHP PF02811.14 CDI84012.1 - 1.3 8.8 5.1 1.7 8.4 1.0 2.2 1 1 1 2 2 2 0 PHP domain Reo_sigmaC PF04582.7 CDI84012.1 - 1.9 7.6 5.1 0.64 9.1 0.2 2.2 2 1 0 2 2 2 0 Reovirus sigma C capsid protein Med11 PF10280.4 CDI84012.1 - 5.1 7.1 22.9 0.032 14.2 3.1 3.5 3 1 0 3 3 3 0 Mediator complex protein DUF2360 PF10152.4 CDI84015.1 - 4.6 7.5 5.7 37 4.5 1.4 2.6 2 2 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Adap_comp_sub PF00928.16 CDI84016.1 - 0.00048 19.3 0.0 0.00064 18.9 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Serglycin PF04360.7 CDI84016.1 - 0.023 14.4 0.1 0.037 13.7 0.1 1.3 1 0 0 1 1 1 0 Serglycin AAA PF00004.24 CDI84018.1 - 3.9e-45 153.2 0.1 1.7e-44 151.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDI84018.1 - 1.7e-08 34.2 0.2 5.2e-08 32.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CDI84018.1 - 1.7e-08 34.5 0.0 3.2e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 CDI84018.1 - 2e-07 31.2 0.3 4.7e-05 23.5 0.2 2.6 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 CDI84018.1 - 3.5e-06 27.1 0.1 1.1e-05 25.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 CDI84018.1 - 2e-05 23.7 0.0 4.5e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 CDI84018.1 - 3.6e-05 22.7 0.0 6.4e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 CDI84018.1 - 0.00018 21.5 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDI84018.1 - 0.00021 22.1 0.1 0.00053 20.7 0.0 1.7 2 1 0 2 2 1 1 AAA domain RNA_helicase PF00910.17 CDI84018.1 - 0.00032 20.8 0.0 0.00075 19.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 CDI84018.1 - 0.00037 19.9 0.7 0.018 14.4 0.0 2.2 1 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 CDI84018.1 - 0.00039 20.1 0.1 0.0048 16.6 0.0 2.2 2 0 0 2 2 2 1 NTPase AAA_33 PF13671.1 CDI84018.1 - 0.0005 19.9 0.3 0.0015 18.4 0.1 2.0 2 1 0 2 2 1 1 AAA domain TIP49 PF06068.8 CDI84018.1 - 0.00051 18.8 0.1 0.0061 15.3 0.0 2.3 2 1 1 3 3 3 1 TIP49 C-terminus IstB_IS21 PF01695.12 CDI84018.1 - 0.00064 19.1 0.0 0.0017 17.8 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 CDI84018.1 - 0.00075 18.7 0.0 0.0018 17.5 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 CDI84018.1 - 0.00092 18.3 0.0 0.0015 17.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Arch_ATPase PF01637.13 CDI84018.1 - 0.0012 18.5 0.0 0.022 14.4 0.0 2.1 1 1 0 2 2 2 1 Archaeal ATPase NACHT PF05729.7 CDI84018.1 - 0.0018 17.9 0.1 0.033 13.8 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.1 CDI84018.1 - 0.0019 18.1 0.0 0.0032 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDI84018.1 - 0.002 17.8 0.3 0.005 16.5 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_3 PF07726.6 CDI84018.1 - 0.0021 17.6 0.0 0.012 15.2 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 CDI84018.1 - 0.0021 17.6 0.1 0.0043 16.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDI84018.1 - 0.004 17.4 0.0 0.0087 16.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 CDI84018.1 - 0.0046 16.4 0.3 0.041 13.3 0.0 2.2 2 1 0 2 2 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 CDI84018.1 - 0.0052 16.4 0.0 0.0087 15.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 KaiC PF06745.8 CDI84018.1 - 0.0079 15.3 0.1 0.29 10.2 0.0 2.2 2 0 0 2 2 2 1 KaiC Parvo_NS1 PF01057.12 CDI84018.1 - 0.012 14.5 0.0 0.02 13.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 CDI84018.1 - 0.014 14.3 0.0 0.027 13.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_11 PF13086.1 CDI84018.1 - 0.014 14.9 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 CDI84018.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.22 CDI84018.1 - 0.021 15.1 0.0 0.066 13.5 0.0 2.0 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 CDI84018.1 - 0.028 13.9 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 CDI84018.1 - 0.039 13.1 0.0 0.1 11.8 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Torsin PF06309.6 CDI84018.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Torsin Bac_DnaA PF00308.13 CDI84018.1 - 0.071 12.7 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_10 PF12846.2 CDI84018.1 - 0.083 12.3 0.4 0.44 9.9 0.3 2.3 1 1 0 1 1 1 0 AAA-like domain FAM60A PF15396.1 CDI84019.1 - 0.0026 17.5 3.4 0.0038 16.9 2.4 1.3 1 0 0 1 1 1 1 Protein Family FAM60A CDC45 PF02724.9 CDI84019.1 - 0.0029 15.7 1.5 0.0034 15.4 1.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Mem_trans PF03547.13 CDI84019.1 - 0.029 12.6 0.2 0.029 12.6 0.1 1.2 1 0 0 1 1 1 0 Membrane transport protein Hid1 PF12722.2 CDI84019.1 - 0.055 11.1 7.6 0.066 10.8 5.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.11 CDI84019.1 - 0.17 11.7 1.7 0.24 11.2 1.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.12 CDI84019.1 - 0.4 9.4 2.7 0.5 9.1 1.9 1.1 1 0 0 1 1 1 0 Presenilin FLO_LFY PF01698.11 CDI84019.1 - 0.6 8.8 4.6 0.92 8.2 3.2 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein DUF755 PF05501.6 CDI84019.1 - 0.71 9.9 36.8 0.044 13.8 21.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF755) AF-4 PF05110.8 CDI84019.1 - 0.92 7.2 21.2 1.2 6.8 14.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Kei1 PF08552.6 CDI84019.1 - 1 9.0 5.8 1.9 8.1 4.0 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Pap_E4 PF02711.9 CDI84019.1 - 1 10.2 6.5 2.4 9.0 4.5 1.6 1 0 0 1 1 1 0 E4 protein FimP PF09766.4 CDI84019.1 - 1.5 7.7 12.8 2.8 6.9 8.9 1.4 1 0 0 1 1 1 0 Fms-interacting protein Raftlin PF15250.1 CDI84019.1 - 1.8 6.9 9.6 2.9 6.3 6.6 1.2 1 0 0 1 1 1 0 Raftlin DUF3513 PF12026.3 CDI84019.1 - 2.3 7.7 15.7 7.1 6.1 9.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3513) AIF_C PF14721.1 CDI84019.1 - 2.5 8.3 7.0 5.5 7.2 4.9 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF2217 PF10265.4 CDI84019.1 - 2.6 6.7 16.1 0.51 9.0 8.9 1.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2217) Paramyxo_ncap PF00973.14 CDI84019.1 - 2.8 6.5 6.0 4.8 5.7 4.2 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Gag_spuma PF03276.9 CDI84019.1 - 3.2 5.9 16.7 4.2 5.5 11.6 1.1 1 0 0 1 1 1 0 Spumavirus gag protein BAF1_ABF1 PF04684.8 CDI84019.1 - 3.4 6.4 14.8 4.6 5.9 10.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DNA_pol_viral_N PF00242.12 CDI84019.1 - 4.7 6.1 15.1 7.4 5.4 10.4 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DHHW PF14286.1 CDI84019.1 - 5.2 6.2 7.9 7.7 5.7 5.4 1.1 1 0 0 1 1 1 0 DHHW protein DUF4175 PF13779.1 CDI84019.1 - 5.7 4.4 16.8 8.4 3.9 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Apt1 PF10351.4 CDI84019.1 - 6 5.5 15.9 9.1 5.0 11.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PRCC PF10253.4 CDI84020.1 - 4.2e-16 60.1 10.6 4.2e-16 60.1 7.3 3.5 2 1 0 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting Tic22 PF04278.7 CDI84021.1 - 5.9e-12 45.4 0.8 4.7e-06 26.0 0.0 3.6 3 1 0 3 3 3 3 Tic22-like family Spt20 PF12090.3 CDI84021.1 - 0.055 12.8 1.1 0.27 10.5 0.0 2.1 2 0 0 2 2 2 0 Spt20 family ABC_tran_2 PF12848.2 CDI84021.1 - 4.3 7.2 13.5 0.86 9.4 4.6 2.3 2 0 0 2 2 2 0 ABC transporter SR-25 PF10500.4 CDI84025.1 - 0.0056 16.1 7.1 0.0056 16.1 4.9 2.2 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein eRF1_1 PF03463.10 CDI84027.1 - 8.4e-31 106.2 0.1 1.4e-30 105.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.10 CDI84027.1 - 1.2e-19 70.9 0.0 2.1e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 CDI84027.1 - 4e-15 56.0 0.0 1.1e-14 54.5 0.0 1.8 1 0 0 1 1 1 1 eRF1 domain 3 SR-25 PF10500.4 CDI84027.1 - 0.068 12.6 4.8 0.14 11.6 3.3 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAT1 PF09770.4 CDI84029.1 - 0.00045 18.6 14.9 0.00045 18.6 10.3 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 SR-25 PF10500.4 CDI84029.1 - 0.0035 16.8 13.5 0.0051 16.3 9.4 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Pex14_N PF04695.8 CDI84029.1 - 0.013 15.5 13.9 0.026 14.5 9.6 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Suf PF05843.9 CDI84029.1 - 0.054 13.2 14.1 0.072 12.8 9.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RP-C_C PF11800.3 CDI84029.1 - 0.13 11.9 11.8 0.22 11.1 8.2 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region DDHD PF02862.12 CDI84029.1 - 0.16 11.7 9.5 0.21 11.3 6.6 1.5 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.7 CDI84029.1 - 0.21 11.4 19.5 0.35 10.7 13.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SprA-related PF12118.3 CDI84029.1 - 0.29 10.4 31.5 0.49 9.6 21.8 1.3 1 0 0 1 1 1 0 SprA-related family TFIIA PF03153.8 CDI84029.1 - 0.32 10.8 23.5 0.43 10.4 16.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spore_coat_CotO PF14153.1 CDI84029.1 - 0.38 10.1 18.5 0.57 9.5 12.8 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DUF789 PF05623.7 CDI84029.1 - 0.55 9.6 8.8 0.81 9.1 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Lin-8 PF03353.10 CDI84029.1 - 0.63 9.2 14.9 0.87 8.8 10.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist XRN_N PF03159.13 CDI84029.1 - 0.82 9.0 5.3 1.2 8.4 3.7 1.4 1 1 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus AUX_IAA PF02309.11 CDI84029.1 - 0.9 9.2 10.1 1.3 8.7 7.0 1.4 1 0 0 1 1 1 0 AUX/IAA family DUF4557 PF15101.1 CDI84029.1 - 0.94 9.2 16.1 1.5 8.6 11.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Hid1 PF12722.2 CDI84029.1 - 1.1 6.7 11.1 1.2 6.6 7.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.1 CDI84029.1 - 1.3 8.7 10.5 2 8.0 7.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Ndc1_Nup PF09531.5 CDI84029.1 - 2.3 6.5 8.6 2.6 6.3 5.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF913 PF06025.7 CDI84029.1 - 2.7 6.6 7.0 3.9 6.1 4.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.9 CDI84029.1 - 3.2 5.6 16.7 3.9 5.3 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.17 CDI84029.1 - 3.8 6.4 5.0 4.7 6.1 3.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.11 CDI84029.1 - 4.3 7.1 8.9 6.5 6.5 6.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FLO_LFY PF01698.11 CDI84029.1 - 5.2 5.8 13.1 8.6 5.0 9.1 1.4 1 0 0 1 1 1 0 Floricaula / Leafy protein BTV_NS2 PF04514.7 CDI84029.1 - 5.7 5.7 14.6 7.8 5.2 10.1 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Pribosyltran PF00156.22 CDI84030.1 - 3.5e-13 49.3 0.0 5.3e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Resolvase PF00239.16 CDI84030.1 - 0.08 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Resolvase, N terminal domain PRTase_2 PF15609.1 CDI84030.1 - 0.13 11.5 0.1 0.19 10.9 0.1 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase CTP_transf_2 PF01467.21 CDI84031.1 - 9.3e-19 68.0 0.1 1.7e-18 67.1 0.1 1.5 1 0 0 1 1 1 1 Cytidylyltransferase Rootletin PF15035.1 CDI84032.1 - 0.0013 18.7 1.5 0.0013 18.7 1.1 3.3 3 0 0 3 3 3 1 Ciliary rootlet component, centrosome cohesion TPR_MLP1_2 PF07926.7 CDI84032.1 - 0.0024 17.6 19.0 0.0024 17.6 13.2 3.7 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein ATG16 PF08614.6 CDI84032.1 - 0.0064 16.3 31.5 0.76 9.5 3.5 3.5 3 0 0 3 3 3 3 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 CDI84032.1 - 0.044 12.9 9.4 0.43 9.7 1.7 3.0 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Lebercilin PF15619.1 CDI84032.1 - 0.047 13.1 32.3 0.02 14.3 10.3 3.4 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease T2SF PF00482.18 CDI84032.1 - 0.84 9.5 5.2 1.7 8.5 2.3 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF677 PF05055.7 CDI84032.1 - 1.5 7.3 11.5 0.042 12.5 2.9 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF677) DUF812 PF05667.6 CDI84032.1 - 2 6.8 24.9 0.0086 14.6 4.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF812) KH_1 PF00013.24 CDI84033.1 - 3.6e-19 68.1 0.1 2.9e-06 26.8 0.0 6.4 6 0 0 6 6 6 5 KH domain KH_3 PF13014.1 CDI84033.1 - 1.1e-06 28.0 0.5 0.14 11.8 0.0 4.2 5 0 0 5 5 5 2 KH domain BMC PF00936.14 CDI84033.1 - 4.1e-05 23.1 3.7 0.061 13.0 0.0 5.1 4 1 1 5 5 5 2 BMC domain KH_2 PF07650.12 CDI84033.1 - 0.048 13.2 8.7 2.1 7.9 0.0 4.2 4 0 0 4 4 4 0 KH domain PRA1 PF03208.14 CDI84034.1 - 2.6e-17 62.5 0.0 3.6e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 PRA1 family protein TFIIB PF00382.14 CDI84035.1 - 2.7e-11 43.1 0.2 2.7e-11 43.1 0.1 2.5 3 0 0 3 3 3 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 CDI84035.1 - 8.5e-08 31.3 2.5 1.5e-07 30.6 1.7 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding BRF1 PF07741.8 CDI84035.1 - 3.5e-07 30.3 2.1 3.5e-07 30.3 1.5 3.0 3 1 0 3 3 3 1 Brf1-like TBP-binding domain DUF4503 PF14951.1 CDI84035.1 - 0.052 11.6 3.0 2.6 6.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4503) DUF2981 PF11200.3 CDI84038.1 - 0.79 8.7 5.6 0.93 8.5 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) UPF0020 PF01170.13 CDI84040.1 - 0.0005 19.6 0.5 0.045 13.3 0.0 2.6 1 1 1 2 2 2 1 Putative RNA methylase family UPF0020 DUF2852 PF11014.3 CDI84040.1 - 0.0021 18.0 5.3 0.0033 17.3 3.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2852) Ycf1 PF05758.7 CDI84040.1 - 0.0051 14.6 15.5 0.0057 14.4 10.7 1.0 1 0 0 1 1 1 1 Ycf1 DUF1510 PF07423.6 CDI84040.1 - 0.0062 15.9 22.6 0.0076 15.6 15.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) DUF2201_N PF13203.1 CDI84040.1 - 0.03 13.5 13.3 0.032 13.3 9.2 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Methyltransf_26 PF13659.1 CDI84040.1 - 0.042 13.8 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GAGA_bind PF06217.7 CDI84040.1 - 0.1 12.5 18.9 0.13 12.2 13.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Sporozoite_P67 PF05642.6 CDI84040.1 - 0.19 9.5 5.9 0.2 9.4 4.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2561 PF10812.3 CDI84040.1 - 0.25 10.9 1.0 0.43 10.1 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2561) DDHD PF02862.12 CDI84040.1 - 0.29 10.8 13.0 0.38 10.5 9.0 1.3 1 0 0 1 1 1 0 DDHD domain Zip PF02535.17 CDI84040.1 - 0.33 9.9 7.0 0.39 9.6 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.1 CDI84040.1 - 0.41 8.7 12.0 0.48 8.5 8.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.7 CDI84040.1 - 0.66 8.6 12.4 0.85 8.2 8.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nucleoside_tran PF01733.13 CDI84040.1 - 1.2 8.2 5.0 1.9 7.5 3.5 1.4 1 0 0 1 1 1 0 Nucleoside transporter FLO_LFY PF01698.11 CDI84040.1 - 2 7.1 17.5 2.4 6.9 12.1 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Gag_spuma PF03276.9 CDI84040.1 - 7.5 4.7 27.1 8.8 4.5 18.8 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Neur_chan_memb PF02932.11 CDI84040.1 - 9.9 5.9 14.6 13 5.6 10.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ABC_tran PF00005.22 CDI84041.1 - 5.2e-27 94.8 0.0 5.2e-27 94.8 0.0 3.4 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.1 CDI84041.1 - 1.1e-05 25.5 1.1 0.0071 16.3 0.0 2.4 3 0 0 3 3 2 2 AAA domain Spore_coat_CotO PF14153.1 CDI84041.1 - 1.8e-05 24.2 2.6 1.8e-05 24.2 1.8 2.6 3 0 0 3 3 2 1 Spore coat protein CotO ABC_membrane PF00664.18 CDI84041.1 - 2.7e-05 23.7 0.9 5.5e-05 22.7 0.6 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region Med15 PF09606.5 CDI84041.1 - 0.00012 20.4 71.7 0.0014 16.9 19.7 3.0 3 0 0 3 3 3 2 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.9 CDI84041.1 - 0.00083 19.1 22.7 0.0036 17.0 2.3 2.6 2 0 0 2 2 2 2 Suppressor of forked protein (Suf) AAA_11 PF13086.1 CDI84041.1 - 0.00091 18.8 0.6 0.00091 18.8 0.4 2.7 3 0 0 3 3 3 1 AAA domain Neur_chan_memb PF02932.11 CDI84041.1 - 0.0017 18.2 15.0 0.004 17.0 0.8 2.4 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region AAA PF00004.24 CDI84041.1 - 0.0043 17.2 3.7 0.061 13.5 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDI84041.1 - 0.012 16.4 0.8 0.024 15.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain tRNA_synt_1c_R2 PF04557.10 CDI84041.1 - 0.016 15.8 7.1 0.016 15.8 4.9 2.9 2 2 0 2 2 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 UPF0079 PF02367.12 CDI84041.1 - 0.018 14.6 0.1 0.018 14.6 0.1 2.2 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 CDI84041.1 - 0.026 14.6 4.7 0.064 13.4 0.3 3.2 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CDI84041.1 - 0.026 14.4 0.0 0.41 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CDI84041.1 - 0.027 14.7 0.1 0.027 14.7 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 CDI84041.1 - 0.065 12.6 0.3 0.29 10.5 0.2 2.1 2 0 0 2 2 1 0 AAA domain SAGA-Tad1 PF12767.2 CDI84041.1 - 0.1 12.2 34.7 0.15 11.7 8.4 3.2 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit AAA_33 PF13671.1 CDI84041.1 - 0.11 12.3 0.0 0.11 12.3 0.0 4.5 4 1 0 4 4 2 0 AAA domain PRK PF00485.13 CDI84041.1 - 0.13 11.8 0.0 0.13 11.8 0.0 2.7 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family PAT1 PF09770.4 CDI84041.1 - 0.21 9.7 57.4 0.069 11.3 15.3 2.4 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 OATP PF03137.15 CDI84041.1 - 0.3 9.1 15.6 0.014 13.4 0.5 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TFIIA PF03153.8 CDI84041.1 - 0.74 9.6 49.3 0.55 10.0 11.0 2.6 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF4448 PF14610.1 CDI84041.1 - 1.6 8.1 6.6 0.9 8.9 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) OmpH PF03938.9 CDI84041.1 - 2.3 8.1 66.2 0.093 12.6 12.9 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) TraH_2 PF06871.6 CDI84041.1 - 2.6 7.4 13.1 0.071 12.5 1.0 2.4 2 0 0 2 2 2 0 TraH_2 Peptidase_S49_N PF08496.5 CDI84041.1 - 4 7.2 28.8 0.25 11.1 8.3 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal MRP-S31 PF15433.1 CDI84041.1 - 4.3 6.6 34.9 3.3 7.0 6.6 3.0 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S31 Peptidase_C58 PF03543.9 CDI84041.1 - 4.6 6.6 33.5 0.35 10.3 9.7 2.7 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen DUF2052 PF09747.4 CDI84041.1 - 5.9 6.7 37.1 0.5 10.2 8.7 2.7 3 0 0 3 3 2 0 Coiled-coil domain containing protein (DUF2052) Dynamin_N PF00350.18 CDI84041.1 - 6.1 6.6 23.4 0.32 10.8 2.9 3.0 3 0 0 3 3 3 0 Dynamin family GAGA_bind PF06217.7 CDI84041.1 - 7.2 6.4 26.1 2.5 7.9 4.8 3.0 3 0 0 3 3 3 0 GAGA binding protein-like family F-protein PF00469.15 CDI84041.1 - 8.9 5.6 23.3 5.4 6.3 5.1 2.5 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Metallophos PF00149.23 CDI84043.1 - 1.8e-50 171.1 0.0 7.9e-33 113.5 0.0 2.1 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase NYD-SP12_N PF15015.1 CDI84043.1 - 0.033 12.4 0.0 0.046 11.9 0.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal FlxA PF14282.1 CDI84043.1 - 0.2 11.6 3.6 0.34 10.8 2.5 1.3 1 0 0 1 1 1 0 FlxA-like protein SR-25 PF10500.4 CDI84043.1 - 6.3 6.2 13.2 0.037 13.5 3.4 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein WES_acyltransf PF03007.11 CDI84045.1 - 0.0092 15.5 10.4 0.014 15.0 7.2 1.2 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF2076 PF09849.4 CDI84045.1 - 0.18 11.8 23.4 0.26 11.3 16.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Spt20 PF12090.3 CDI84045.1 - 0.24 10.7 10.8 0.36 10.1 7.5 1.3 1 0 0 1 1 1 0 Spt20 family ALMT PF11744.3 CDI84045.1 - 0.33 9.5 1.6 0.43 9.1 1.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Tubulin_3 PF14881.1 CDI84045.1 - 0.81 9.1 3.9 1.1 8.6 2.7 1.2 1 0 0 1 1 1 0 Tubulin domain DUF572 PF04502.8 CDI84045.1 - 1.1 8.4 12.3 1.4 8.0 8.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Band_3_cyto PF07565.8 CDI84045.1 - 1.2 8.5 8.5 1.4 8.3 5.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Draxin PF15550.1 CDI84045.1 - 1.2 8.7 10.0 1.8 8.1 6.9 1.3 1 0 0 1 1 1 0 Draxin TFIIA PF03153.8 CDI84045.1 - 1.7 8.4 24.2 2.1 8.1 16.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.5 CDI84045.1 - 2.4 6.2 39.6 4 5.5 27.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal YscJ_FliF_C PF08345.6 CDI84045.1 - 4.1 7.3 16.9 5.6 6.9 11.7 1.1 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal Ndc1_Nup PF09531.5 CDI84045.1 - 7 4.9 7.4 7 4.9 5.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF966 PF06136.8 CDI84045.1 - 7.2 5.9 12.0 9.3 5.5 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) eIF-3_zeta PF05091.7 CDI84045.1 - 9.9 4.6 15.8 12 4.3 10.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S15 PF02129.13 CDI84047.1 - 3.7e-35 121.6 13.9 1e-34 120.2 0.0 4.1 4 0 0 4 4 4 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 CDI84047.1 - 1.7e-16 60.7 12.4 3.1e-15 56.6 0.0 3.8 3 2 0 3 3 3 2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_6 PF12697.2 CDI84047.1 - 2.7e-06 27.4 7.0 8.2e-06 25.8 0.1 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDI84047.1 - 5.2e-06 26.2 1.5 1.1e-05 25.2 0.1 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CDI84047.1 - 1 8.5 7.3 0.029 13.6 0.4 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Pox_Ag35 PF03286.9 CDI84047.1 - 1.3 8.4 22.2 2.2 7.7 10.7 2.8 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Zip PF02535.17 CDI84047.1 - 1.8 7.5 14.3 6.1 5.7 9.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter SR-25 PF10500.4 CDI84048.1 - 0.22 10.9 41.4 0.2 11.1 5.9 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Hat1_N PF10394.4 CDI84050.1 - 1.4e-05 25.2 0.0 2.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Kinesin PF00225.18 CDI84051.1 - 8.7e-63 212.0 0.6 8.7e-63 212.0 0.4 2.8 3 1 0 3 3 3 1 Kinesin motor domain WD40 PF00400.27 CDI84052.1 - 3 7.8 0.0 3 7.8 0.0 5.5 7 0 0 7 7 7 0 WD domain, G-beta repeat K_channel_TID PF07941.6 CDI84053.1 - 0.018 15.2 26.9 0.13 12.5 4.4 3.4 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s PF00428.14 CDI84053.1 - 0.29 11.5 18.1 1.9 8.9 1.8 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein PA14 PF07691.7 CDI84054.1 - 9e-16 57.8 0.0 2.4e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 PA14 domain Shadoo PF14999.1 CDI84054.1 - 0.18 11.6 20.4 1.1 9.1 3.7 2.5 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Ribosomal_60s PF00428.14 CDI84054.1 - 0.62 10.4 22.9 1.7 9.0 2.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein cwf18 PF08315.7 CDI84055.1 - 5.7e-29 101.1 0.8 5.7e-29 101.1 0.6 2.0 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor SCP1201-deam PF14428.1 CDI84055.1 - 0.051 13.2 0.0 0.1 12.3 0.0 1.5 1 1 0 1 1 1 0 SCP1.201-like deaminase RGS-like PF09128.6 CDI84055.1 - 1.2 8.5 6.5 1.5 8.2 4.5 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain DUF866 PF05907.8 CDI84056.1 - 1.1e-09 37.9 1.3 3.4e-08 33.1 0.0 2.8 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF866) Fer4_4 PF12800.2 CDI84056.1 - 0.23 11.9 4.0 0.45 10.9 2.8 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain Raftlin PF15250.1 CDI84056.1 - 0.42 9.0 8.4 0.47 8.9 5.8 1.1 1 0 0 1 1 1 0 Raftlin SprA-related PF12118.3 CDI84056.1 - 0.43 9.8 14.7 0.48 9.7 10.2 1.2 1 0 0 1 1 1 0 SprA-related family Macoilin PF09726.4 CDI84056.1 - 0.66 8.1 25.9 0.64 8.2 18.0 1.1 1 0 0 1 1 1 0 Transmembrane protein CytochromB561_N PF09786.4 CDI84056.1 - 0.92 7.8 21.6 0.97 7.8 15.0 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DNA_pol_viral_N PF00242.12 CDI84056.1 - 3 6.7 18.1 3.3 6.6 12.5 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF508 PF04370.7 CDI84060.1 - 0.41 10.2 4.8 0.43 10.1 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF508) SSP160 PF06933.6 CDI84060.1 - 3.3 5.5 8.0 2.9 5.7 5.6 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CAF-1_p150 PF11600.3 CDI84060.1 - 3.4 6.9 5.7 3.3 7.0 4.0 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Aerolysin PF01117.15 CDI84061.1 - 0.16 10.8 0.1 0.23 10.3 0.1 1.1 1 0 0 1 1 1 0 Aerolysin toxin Pkinase PF00069.20 CDI84062.1 - 2.2e-54 184.3 6.3 5.1e-53 179.8 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84062.1 - 3.7e-19 68.8 0.9 3e-16 59.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 CDI84062.1 - 9.5e-06 25.5 7.8 0.0007 19.3 5.4 3.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDI84062.1 - 0.039 13.5 0.1 0.039 13.5 0.1 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase Gly-zipper_OmpA PF13436.1 CDI84062.1 - 0.07 12.7 20.9 0.13 11.9 14.5 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Hid1 PF12722.2 CDI84062.1 - 0.34 8.5 6.3 0.45 8.1 4.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YrbL-PhoP_reg PF10707.4 CDI84062.1 - 0.36 10.1 0.0 0.36 10.1 0.0 3.2 4 0 0 4 4 4 0 PhoP regulatory network protein YrbL SpaB_C PF14028.1 CDI84062.1 - 0.78 9.2 7.1 1.4 8.4 4.9 1.3 1 0 0 1 1 1 0 SpaB C-terminal domain DUF4407 PF14362.1 CDI84062.1 - 1.3 7.9 12.6 1.9 7.3 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDK2AP PF09806.4 CDI84062.1 - 3.8 7.7 17.3 7.7 6.6 12.0 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Med15 PF09606.5 CDI84062.1 - 4 5.5 40.2 5.8 4.9 27.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.11 CDI84062.1 - 9.9 5.9 7.9 16 5.3 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TBP PF00352.16 CDI84067.1 - 1.1e-14 53.5 0.1 0.00021 20.6 0.0 3.3 3 0 0 3 3 3 3 Transcription factor TFIID (or TATA-binding protein, TBP) IncA PF04156.9 CDI84067.1 - 0.0016 18.0 6.9 0.0016 18.0 4.8 2.1 2 0 0 2 2 2 1 IncA protein Peptidase_S49_N PF08496.5 CDI84067.1 - 0.02 14.6 2.5 0.042 13.6 1.7 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Med15 PF09606.5 CDI84067.1 - 0.04 12.1 24.9 0.066 11.4 17.2 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 CDI84067.1 - 0.55 10.0 21.1 0.96 9.2 14.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4557 PF15101.1 CDI84067.1 - 1.9 8.2 9.1 3.1 7.5 6.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) TRP PF06011.7 CDI84067.1 - 3.3 6.1 6.2 5 5.5 4.3 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel ATP-synt_ab PF00006.20 CDI84068.1 - 4.3e-60 202.8 0.0 6.3e-60 202.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.18 CDI84068.1 - 2.4e-08 34.0 0.1 6.2e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab_C PF00306.22 CDI84068.1 - 3.6e-06 27.4 0.2 6.7e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain cNMP_binding PF00027.24 CDI84071.1 - 4e-18 64.9 1.6 2.6e-07 30.3 0.1 3.5 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Gti1_Pac2 PF09729.4 CDI84071.1 - 1.1 9.0 15.0 1.4 8.7 1.9 2.6 2 0 0 2 2 2 0 Gti1/Pac2 family AAA_11 PF13086.1 CDI84071.1 - 1.8 8.0 28.6 0.72 9.3 2.7 2.6 2 1 0 2 2 2 0 AAA domain PAT1 PF09770.4 CDI84071.1 - 1.8 6.6 88.3 0.13 10.4 32.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SAGA-Tad1 PF12767.2 CDI84071.1 - 1.8 8.1 39.4 0.31 10.6 7.9 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Ycf1 PF05758.7 CDI84071.1 - 3.8 5.1 22.3 2 6.0 4.4 2.2 2 0 0 2 2 2 0 Ycf1 GAGA_bind PF06217.7 CDI84071.1 - 4.6 7.1 31.8 1.6 8.6 7.2 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family DUF1168 PF06658.7 CDI84071.1 - 6.3 6.3 47.0 0.28 10.7 9.6 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1168) YjgP_YjgQ PF03739.9 CDI84071.1 - 6.3 5.4 7.3 4.7 5.8 0.3 2.2 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family Prp19_bind PF06991.6 CDI84072.1 - 1.1e-57 195.4 36.0 1.1e-57 195.4 25.0 3.0 1 1 1 2 2 2 1 Splicing factor, Prp19-binding domain Med15 PF09606.5 CDI84072.1 - 1.9 6.5 28.5 3 5.9 19.8 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal WW PF00397.21 CDI84073.1 - 4.4e-16 58.4 9.8 7.2e-10 38.5 1.8 2.8 2 0 0 2 2 2 2 WW domain FF PF01846.14 CDI84073.1 - 2.2e-15 56.3 13.6 2.8e-09 36.7 0.0 4.6 4 0 0 4 4 4 2 FF domain CDC45 PF02724.9 CDI84073.1 - 1.6 6.6 28.0 0.034 12.1 14.5 1.9 2 0 0 2 2 2 0 CDC45-like protein YTH PF04146.10 CDI84074.1 - 4.4e-15 55.5 0.0 8.7e-07 28.6 0.0 2.2 2 0 0 2 2 2 2 YT521-B-like domain DnaJ PF00226.26 CDI84075.1 - 2.1e-15 56.1 0.0 4.7e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Cwf_Cwc_15 PF04889.7 CDI84075.1 - 0.0014 18.4 2.1 0.0021 17.7 1.5 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Dehydrin PF00257.14 CDI84075.1 - 0.022 15.1 0.9 0.031 14.5 0.6 1.4 1 0 0 1 1 1 0 Dehydrin DUF755 PF05501.6 CDI84075.1 - 1.3 9.0 24.4 3.7 7.6 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF1117 PF06547.7 CDI84075.1 - 2.1 8.4 7.8 0.49 10.4 2.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) MRI PF15325.1 CDI84075.1 - 4.4 8.3 8.5 1.6 9.7 2.8 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection DUF4602 PF15375.1 CDI84075.1 - 4.7 7.2 7.8 0.37 10.8 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4602) DUF3801 PF12687.2 CDI84077.1 - 1.4 8.4 12.4 0.014 14.9 2.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3801) Spt20 PF12090.3 CDI84077.1 - 3.8 6.8 12.3 1.3 8.3 1.8 3.2 3 0 0 3 3 3 0 Spt20 family DUF3843 PF12954.2 CDI84077.1 - 5.5 5.9 9.7 0.37 9.7 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3843) Peptidase_S8 PF00082.17 CDI84081.1 - 8.3e-50 169.5 0.5 1.2e-49 168.9 0.3 1.2 1 0 0 1 1 1 1 Subtilase family Tmemb_cc2 PF10267.4 CDI84081.1 - 0.083 11.4 0.4 0.15 10.6 0.3 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SR-25 PF10500.4 CDI84081.1 - 1.3 8.4 7.6 2.1 7.7 5.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Muted PF14942.1 CDI84082.1 - 0.56 10.0 15.4 0.42 10.4 2.5 3.3 4 0 0 4 4 4 0 Organelle biogenesis, Muted-like protein BRF1 PF07741.8 CDI84082.1 - 0.78 9.9 12.7 3.2 8.0 3.1 3.2 3 0 0 3 3 3 0 Brf1-like TBP-binding domain DUF1266 PF06889.6 CDI84082.1 - 3.9 7.2 11.7 1.5 8.5 3.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1266) Activator_LAG-3 PF11498.3 CDI84082.1 - 5.2 5.7 21.5 0.18 10.5 9.9 2.0 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF1764 PF08576.5 CDI84082.1 - 9.2 7.1 10.7 5.5 7.8 1.7 2.9 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) Glyco_transf_17 PF04724.8 CDI84083.1 - 3.7e-17 62.3 2.7 4.9e-16 58.6 1.9 2.1 1 1 0 1 1 1 1 Glycosyltransferase family 17 Esterase PF00756.15 CDI84083.1 - 0.29 10.5 6.4 0.54 9.6 4.4 1.3 1 0 0 1 1 1 0 Putative esterase TFIIA PF03153.8 CDI84083.1 - 0.44 10.4 26.8 0.077 12.8 15.9 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SAGA-Tad1 PF12767.2 CDI84083.1 - 0.45 10.1 16.0 0.87 9.1 11.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit FAM60A PF15396.1 CDI84083.1 - 0.71 9.5 10.7 1.4 8.6 7.4 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.12 CDI84083.1 - 1.2 7.9 6.4 2.2 7.0 4.4 1.4 1 0 0 1 1 1 0 Presenilin Spore_coat_CotO PF14153.1 CDI84083.1 - 1.4 8.3 21.9 2.9 7.3 15.2 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Dicty_REP PF05086.7 CDI84083.1 - 3.8 5.1 8.0 5.4 4.6 5.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Borrelia_P83 PF05262.6 CDI84083.1 - 7.4 4.7 13.9 11 4.1 9.6 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4638 PF15472.1 CDI84083.1 - 7.8 6.0 13.4 13 5.2 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) RR_TM4-6 PF06459.7 CDI84083.1 - 8 6.2 17.6 17 5.1 12.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PP2C PF00481.16 CDI84084.1 - 2.3e-18 66.5 0.0 2.3e-18 66.5 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.7 CDI84084.1 - 0.0005 19.8 0.0 0.0014 18.3 0.0 1.8 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) HABP4_PAI-RBP1 PF04774.10 CDI84085.1 - 9.3e-18 64.6 9.0 9.3e-18 64.6 6.2 3.7 3 1 1 4 4 4 1 Hyaluronan / mRNA binding family Stm1_N PF09598.5 CDI84085.1 - 1.9 9.2 10.9 15 6.3 2.4 3.5 2 0 0 2 2 2 0 Stm1 CEP44 PF15007.1 CDI84086.1 - 8.1e-33 112.9 0.0 2.7e-32 111.2 0.0 1.9 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 GP41 PF00517.12 CDI84086.1 - 0.0089 15.6 2.0 0.0089 15.6 1.4 5.4 6 0 0 6 6 6 1 Retroviral envelope protein RRM_6 PF14259.1 CDI84088.1 - 8.3e-13 48.1 0.0 0.0011 18.8 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI84088.1 - 3.5e-09 36.3 0.0 0.0042 16.9 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI84088.1 - 2.4e-08 33.4 0.0 0.26 10.9 0.0 3.9 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.4 CDI84088.1 - 0.003 17.0 19.6 0.003 17.0 13.6 12.2 8 3 5 13 13 13 2 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.10 CDI84088.1 - 0.02 15.4 0.1 0.02 15.4 0.1 19.0 12 6 5 17 17 17 0 Chorion family 2 DUF572 PF04502.8 CDI84091.1 - 0.81 8.8 28.1 1 8.5 19.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF940 PF06082.6 CDI84091.1 - 1.4 7.3 24.3 1.7 7.1 16.8 1.0 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) TFIIF_alpha PF05793.7 CDI84091.1 - 1.6 7.0 22.0 2 6.6 15.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SLD3 PF08639.5 CDI84091.1 - 2 6.9 32.4 2.2 6.8 22.5 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 Ndc1_Nup PF09531.5 CDI84091.1 - 3.3 6.0 18.8 4.1 5.7 13.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF966 PF06136.8 CDI84091.1 - 4.3 6.6 27.6 6.3 6.1 19.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) UDPG_MGDP_dh_N PF03721.9 CDI84091.1 - 4.7 6.5 8.8 7 5.9 6.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PIG-S PF10510.4 CDI84091.1 - 6 5.4 15.8 8 4.9 10.9 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Utp14 PF04615.8 CDI84091.1 - 7.2 4.6 28.8 7.9 4.5 20.0 1.0 1 0 0 1 1 1 0 Utp14 protein DUF2217 PF10265.4 CDI84091.1 - 7.4 5.2 17.0 9.3 4.8 11.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) CPSase_L_D2 PF02786.12 CDI84094.1 - 2.8e-105 350.2 0.5 8.4e-71 237.5 0.0 3.2 2 1 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 CDI84094.1 - 2.1e-31 108.2 0.1 4.1e-15 55.8 0.0 3.5 4 0 0 4 4 4 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 CDI84094.1 - 4.9e-31 107.8 0.9 9.8e-18 64.5 0.0 3.3 2 1 1 3 3 3 3 ATP-grasp domain ATPgrasp_Ter PF15632.1 CDI84094.1 - 2.1e-22 79.3 0.6 4.7e-14 51.8 0.0 3.4 3 1 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D3 PF02787.14 CDI84094.1 - 1.1e-17 63.9 0.1 2.9e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.8 CDI84094.1 - 1.9e-16 60.0 0.7 2.8e-07 30.1 0.1 3.3 2 1 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CDI84094.1 - 2.3e-14 53.1 0.2 2e-08 33.7 0.1 3.2 2 1 1 3 3 3 2 ATP-grasp domain MGS PF02142.17 CDI84094.1 - 9.6e-12 44.6 0.1 8e-05 22.5 0.0 3.4 3 0 0 3 3 3 2 MGS-like domain ATP-grasp_3 PF02655.9 CDI84094.1 - 2.2e-07 30.8 0.3 0.0024 17.7 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp domain RimK PF08443.6 CDI84094.1 - 0.0018 17.8 0.0 0.064 12.7 0.0 2.8 3 0 0 3 3 3 1 RimK-like ATP-grasp domain DUF2572 PF10833.3 CDI84094.1 - 0.016 14.6 0.4 0.048 13.0 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) ATP-grasp_5 PF13549.1 CDI84094.1 - 0.028 13.6 0.2 0.077 12.1 0.2 1.7 1 0 0 1 1 1 0 ATP-grasp domain HTH_27 PF13463.1 CDI84094.1 - 0.058 13.7 0.1 0.62 10.4 0.0 2.8 3 0 0 3 3 2 0 Winged helix DNA-binding domain TTL PF03133.10 CDI84094.1 - 0.058 12.2 0.0 6.2 5.6 0.0 2.6 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family GARS_A PF01071.14 CDI84094.1 - 0.1 12.1 0.0 0.31 10.5 0.0 1.8 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain LMBR1 PF04791.11 CDI84095.1 - 0.016 13.8 9.6 0.18 10.3 0.1 2.7 2 1 0 2 2 2 0 LMBR1-like membrane protein DUF1032 PF06278.6 CDI84096.1 - 8.3e-08 31.1 0.4 0.00094 17.7 0.0 3.2 3 0 0 3 3 3 3 Protein of unknown function (DUF1032) SR-25 PF10500.4 CDI84098.1 - 0.0036 16.8 2.7 0.0036 16.8 1.8 12.7 10 3 2 12 12 12 1 Nuclear RNA-splicing-associated protein Glycoprotein_B PF00606.13 CDI84098.1 - 0.35 8.8 6.7 0.59 8.0 4.6 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B Cellulose_synt PF03552.9 CDI84098.1 - 8.6 4.5 1.5 17 3.5 1.0 1.4 1 0 0 1 1 1 0 Cellulose synthase Nucleoporin_FG PF13634.1 CDI84099.1 - 0.041 14.1 5.8 0.06 13.5 4.0 1.3 1 0 0 1 1 1 0 Nucleoporin FG repeat region AP2 PF00847.15 CDI84101.1 - 5.5e-06 26.4 0.1 5.5e-06 26.4 0.1 5.1 7 1 0 7 7 7 1 AP2 domain CWC25 PF12542.3 CDI84103.1 - 2.9e-15 56.5 0.0 2.9e-15 56.5 0.0 6.9 5 2 2 7 7 7 1 Pre-mRNA splicing factor SR-25 PF10500.4 CDI84103.1 - 0.00056 19.4 9.6 0.00056 19.4 6.7 5.6 3 1 1 5 5 5 2 Nuclear RNA-splicing-associated protein XPA_C PF05181.7 CDI84104.1 - 0.0031 17.0 0.0 0.0054 16.2 0.0 1.3 1 0 0 1 1 1 1 XPA protein C-terminus PAT1 PF09770.4 CDI84105.1 - 1.9 6.5 21.9 2.7 6.1 15.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Nucleoside_tran PF01733.13 CDI84106.1 - 1.9e-12 46.9 0.4 1.9e-12 46.9 0.3 1.9 2 0 0 2 2 2 1 Nucleoside transporter PGA2 PF07543.7 CDI84106.1 - 0.24 11.1 2.0 0.43 10.3 1.4 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 TAF4 PF05236.9 CDI84106.1 - 1.1 8.4 6.2 1.8 7.7 2.1 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family DUF3138 PF11336.3 CDI84106.1 - 4.7 5.2 8.3 8.1 4.4 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) eIF-5_eIF-2B PF01873.12 CDI84107.1 - 1.4e-35 121.6 0.1 2.3e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Dicty_REP PF05086.7 CDI84107.1 - 0.22 9.2 4.5 0.26 9.0 3.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MIP-T3 PF10243.4 CDI84107.1 - 1.7 7.0 34.5 2.2 6.6 23.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Nop14 PF04147.7 CDI84107.1 - 3.8 5.3 22.8 4.9 4.9 15.8 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.10 CDI84107.1 - 4 5.9 8.9 5.3 5.5 6.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Metallophos_2 PF12850.2 CDI84108.1 - 1e-21 77.4 0.0 1.2e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 CDI84108.1 - 0.00011 21.6 1.5 0.00036 19.9 1.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CHCH PF06747.8 CDI84109.1 - 4.7e-05 23.1 4.8 8.5e-05 22.3 2.6 1.9 1 1 1 2 2 2 2 CHCH domain Ribosomal_L7Ae PF01248.21 CDI84111.1 - 2.1e-22 78.4 1.5 3.7e-22 77.6 1.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CDI84111.1 - 0.027 14.2 0.1 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 RNase P subunit Pop3 DUF1712 PF08217.6 CDI84112.1 - 8.7e-19 67.2 8.7 6.4e-17 61.0 0.0 2.8 2 1 0 2 2 2 2 Fungal domain of unknown function (DUF1712) AAA_23 PF13476.1 CDI84112.1 - 0.00082 19.7 7.7 0.0016 18.7 5.3 1.5 1 0 0 1 1 1 1 AAA domain Suf PF05843.9 CDI84112.1 - 0.0013 18.5 6.2 0.0026 17.5 4.3 1.5 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Ycf1 PF05758.7 CDI84112.1 - 0.0066 14.2 7.5 0.0098 13.6 5.2 1.2 1 0 0 1 1 1 1 Ycf1 Spore_coat_CotO PF14153.1 CDI84112.1 - 0.0096 15.3 16.7 0.0096 15.3 11.6 2.0 2 0 0 2 2 2 1 Spore coat protein CotO zf-DHHC PF01529.15 CDI84112.1 - 0.027 13.8 0.2 0.17 11.2 0.1 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase AUX_IAA PF02309.11 CDI84112.1 - 0.038 13.7 9.4 1.2 8.8 6.7 2.1 2 0 0 2 2 2 0 AUX/IAA family PAT1 PF09770.4 CDI84112.1 - 0.058 11.6 19.9 0.086 11.0 13.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FimP PF09766.4 CDI84112.1 - 0.29 10.1 24.0 0.013 14.6 12.6 1.6 2 0 0 2 2 2 0 Fms-interacting protein Paramyxo_ncap PF00973.14 CDI84112.1 - 0.53 8.9 5.8 0.81 8.3 4.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2126 PF09899.4 CDI84112.1 - 0.55 8.1 6.6 0.78 7.6 4.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Zip PF02535.17 CDI84112.1 - 0.57 9.1 4.4 1.2 8.0 3.0 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter NARP1 PF12569.3 CDI84112.1 - 1.2 7.8 14.2 2.4 6.8 9.8 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Raftlin PF15250.1 CDI84112.1 - 1.5 7.2 13.3 0.034 12.6 4.5 1.6 2 0 0 2 2 2 0 Raftlin Pex14_N PF04695.8 CDI84112.1 - 1.7 8.7 20.9 0.025 14.6 8.2 2.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GvpL_GvpF PF06386.6 CDI84112.1 - 1.7 8.1 14.3 3.7 7.0 9.9 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF PMSI1 PF15322.1 CDI84112.1 - 1.8 7.5 12.2 4.2 6.3 8.5 1.5 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative YABBY PF04690.8 CDI84112.1 - 3 8.0 7.5 0.44 10.7 2.0 1.9 2 0 0 2 2 1 0 YABBY protein Herpes_DNAp_acc PF04929.7 CDI84112.1 - 3.6 6.4 14.4 6.7 5.5 0.5 2.1 2 0 0 2 2 2 0 Herpes DNA replication accessory factor Ctr PF04145.10 CDI84112.1 - 3.7 7.6 4.8 14 5.6 3.3 2.0 1 0 0 1 1 1 0 Ctr copper transporter family FYDLN_acid PF09538.5 CDI84112.1 - 4 8.0 15.3 1.2 9.7 6.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Gti1_Pac2 PF09729.4 CDI84112.1 - 4.2 7.1 9.3 6.5 6.5 5.7 1.8 2 0 0 2 2 2 0 Gti1/Pac2 family Afi1 PF07792.7 CDI84112.1 - 5.8 6.9 17.5 0.27 11.2 6.8 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking eIF-3_zeta PF05091.7 CDI84112.1 - 7.4 5.0 15.0 11 4.4 10.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) IMCp PF12314.3 CDI84113.1 - 5.4e-22 77.7 98.5 2.4e-13 50.0 18.3 5.5 1 1 4 5 5 5 4 Inner membrane complex protein HTH_43 PF09904.4 CDI84113.1 - 0.21 11.4 2.0 6 6.7 0.0 2.8 3 1 0 3 3 3 0 Winged helix-turn helix BAF1_ABF1 PF04684.8 CDI84115.1 - 0.0036 16.2 22.9 0.0036 16.2 15.9 6.1 5 1 1 6 6 6 2 BAF1 / ABF1 chromatin reorganising factor U1snRNP70_N PF12220.3 CDI84115.1 - 0.0078 16.5 4.0 0.0078 16.5 2.8 5.3 4 1 0 5 5 5 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Plasmodium_Vir PF05795.6 CDI84115.1 - 0.078 12.1 0.0 0.078 12.1 0.0 4.5 3 2 1 4 4 4 0 Plasmodium vivax Vir protein PIG-X PF08320.7 CDI84116.1 - 4.2e-08 32.7 0.0 0.0036 16.6 0.0 3.2 2 1 0 2 2 2 2 PIG-X / PBN1 Ribosomal_60s PF00428.14 CDI84116.1 - 0.076 13.4 14.8 1.7 9.1 6.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Asp_Glu_race PF01177.17 CDI84119.1 - 0.025 14.4 0.1 0.053 13.4 0.0 1.5 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase SOBP PF15279.1 CDI84121.1 - 0.0021 18.4 32.5 0.054 13.8 4.1 2.1 2 0 0 2 2 2 2 Sine oculis-binding protein Spt20 PF12090.3 CDI84121.1 - 2.5 7.4 17.5 0.18 11.1 2.3 2.4 2 0 0 2 2 2 0 Spt20 family DUF4050 PF13259.1 CDI84121.1 - 8.6 6.3 20.9 8.8e+02 -0.2 14.5 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) DUF3040 PF11239.3 CDI84124.1 - 3.7 7.6 6.5 1.9 8.6 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Ras PF00071.17 CDI84126.1 - 2.7e-63 212.2 1.0 3.7e-63 211.7 0.7 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI84126.1 - 1.2e-19 70.8 0.0 2.4e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDI84126.1 - 1.4e-16 60.2 0.2 2.2e-16 59.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDI84126.1 - 2.4e-06 26.8 0.1 4.3e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CDI84126.1 - 4.1e-05 22.8 0.1 8.5e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 CDI84126.1 - 0.00015 21.2 0.3 0.00031 20.2 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDI84126.1 - 0.00032 20.6 0.1 0.00058 19.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 CDI84126.1 - 0.0033 17.5 0.0 0.0083 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CDI84126.1 - 0.01 15.0 0.1 0.025 13.7 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 CDI84126.1 - 0.011 15.1 0.4 0.24 10.8 0.0 2.7 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.9 CDI84126.1 - 0.042 13.5 0.0 0.097 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 CDI84126.1 - 0.07 12.7 6.5 0.9 9.1 0.0 3.7 2 1 1 4 4 4 0 NACHT domain AAA_29 PF13555.1 CDI84126.1 - 0.087 12.3 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 CDI84126.1 - 0.22 11.5 0.1 0.22 11.5 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.22 CDI84126.1 - 0.87 9.8 4.0 2.6 8.3 1.3 2.7 2 1 0 2 2 2 0 ABC transporter zf-CCHC_2 PF13696.1 CDI84127.1 - 3.4e-06 26.4 0.4 9.2e-06 25.0 0.3 1.7 1 0 0 1 1 1 1 Zinc knuckle Spt20 PF12090.3 CDI84127.1 - 0.0033 16.7 3.5 0.8 9.0 0.7 2.4 2 0 0 2 2 2 2 Spt20 family zf-C3HC4_2 PF13923.1 CDI84127.1 - 0.0064 16.5 7.2 0.0064 16.5 5.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDI84127.1 - 0.053 13.3 6.8 0.13 12.0 4.7 1.7 1 0 0 1 1 1 0 Ring finger domain zf-CCHC PF00098.18 CDI84127.1 - 0.061 13.2 5.2 0.18 11.8 3.6 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 CDI84127.1 - 0.17 11.5 3.7 0.36 10.5 2.6 1.5 1 0 0 1 1 1 0 Zinc knuckle RAB3GAP2_N PF14655.1 CDI84127.1 - 6 5.7 16.3 0.64 8.9 1.0 2.9 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Thymidylate_kin PF02223.12 CDI84128.1 - 0.00092 18.6 0.6 0.0012 18.2 0.4 1.2 1 0 0 1 1 1 1 Thymidylate kinase RAB3GAP2_N PF14655.1 CDI84128.1 - 0.11 11.5 1.7 0.096 11.6 1.2 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus MSP1_C PF07462.6 CDI84128.1 - 8.5 4.6 10.5 8.2 4.6 7.3 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Med15 PF09606.5 CDI84129.1 - 5.5e-05 21.5 3.1 5.5e-05 21.5 2.2 5.1 7 0 0 7 7 7 3 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.3 CDI84129.1 - 0.061 12.6 13.1 1.1 8.5 0.3 3.4 3 0 0 3 3 3 0 Spt20 family Ycf1 PF05758.7 CDI84129.1 - 1.1 6.9 8.7 0.33 8.6 3.5 1.7 2 0 0 2 2 2 0 Ycf1 Suf PF05843.9 CDI84129.1 - 2.8 7.5 21.3 1.3 8.6 0.2 3.3 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) SNF2_N PF00176.18 CDI84131.1 - 3.4e-19 68.7 2.9 3.4e-19 68.7 2.0 2.4 3 0 0 3 3 3 1 SNF2 family N-terminal domain BacA PF02673.13 CDI84131.1 - 0.032 13.4 0.0 0.079 12.1 0.0 1.6 1 0 0 1 1 1 0 Bacitracin resistance protein BacA ETRAMP PF09716.5 CDI84131.1 - 1.7 8.6 0.0 1.7 8.6 0.0 5.1 5 1 0 6 6 6 0 Malarial early transcribed membrane protein (ETRAMP) DUF3089 PF11288.3 CDI84135.1 - 0.055 12.6 0.1 0.095 11.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3089) Trypsin_2 PF13365.1 CDI84136.1 - 7e-15 55.0 0.9 7e-15 55.0 0.6 2.5 2 1 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.21 CDI84136.1 - 5.6e-12 45.7 0.0 1.8e-11 44.0 0.0 1.8 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 CDI84136.1 - 0.009 15.8 0.0 1.8 8.5 0.0 2.8 2 0 0 2 2 2 2 PDZ domain Med4 PF10018.4 CDI84137.1 - 0.0036 16.7 0.0 0.0082 15.5 0.0 1.6 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 RE_SinI PF09570.5 CDI84137.1 - 0.082 11.8 0.2 0.15 10.9 0.1 1.4 1 0 0 1 1 1 0 SinI restriction endonuclease Borrelia_P83 PF05262.6 CDI84138.1 - 0.71 8.0 13.3 0.87 7.7 9.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Kinesin PF00225.18 CDI84140.1 - 3.9e-22 78.4 12.6 1e-13 50.7 0.0 5.4 4 1 0 4 4 4 2 Kinesin motor domain MFS_1 PF07690.11 CDI84140.1 - 3.5e-17 62.1 22.0 1.9e-10 40.0 1.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 CDI84140.1 - 0.0062 14.6 0.3 0.0062 14.6 0.2 2.8 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF1003 PF06210.6 CDI84141.1 - 0.047 13.6 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) tRNA-synt_2b PF00587.20 CDI84142.1 - 2e-23 82.8 0.0 3.6e-23 81.9 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Med15 PF09606.5 CDI84142.1 - 8.4e-05 20.9 33.1 0.0003 19.1 7.9 2.1 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal FimP PF09766.4 CDI84142.1 - 0.0029 16.7 19.6 0.026 13.5 1.0 2.2 2 0 0 2 2 2 2 Fms-interacting protein Gti1_Pac2 PF09729.4 CDI84142.1 - 0.0072 16.2 1.9 0.39 10.5 0.0 2.2 2 0 0 2 2 2 1 Gti1/Pac2 family Neur_chan_memb PF02932.11 CDI84142.1 - 0.01 15.7 2.2 0.026 14.4 1.5 1.6 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3306 PF11748.3 CDI84142.1 - 0.018 15.6 18.6 0.45 11.1 2.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) CDK2AP PF09806.4 CDI84142.1 - 0.039 14.1 12.0 0.19 11.9 1.5 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein FAM176 PF14851.1 CDI84142.1 - 0.072 12.7 6.4 1.6 8.3 2.2 2.2 2 0 0 2 2 2 0 FAM176 family TFIIA PF03153.8 CDI84142.1 - 0.11 12.3 18.7 0.49 10.2 4.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2795 PF11387.3 CDI84142.1 - 0.13 12.1 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) PAT1 PF09770.4 CDI84142.1 - 0.15 10.3 28.2 0.14 10.3 6.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Rrp15p PF07890.7 CDI84142.1 - 0.15 12.0 16.4 0.063 13.3 4.0 2.3 2 0 0 2 2 2 0 Rrp15p zf-DHHC PF01529.15 CDI84142.1 - 0.2 11.0 5.9 1.1 8.6 0.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF1645 PF07816.6 CDI84142.1 - 0.23 11.8 9.5 0.074 13.5 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Band_3_cyto PF07565.8 CDI84142.1 - 0.24 10.8 12.1 0.56 9.6 3.2 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Suf PF05843.9 CDI84142.1 - 0.25 11.0 16.7 0.58 9.8 1.0 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF913 PF06025.7 CDI84142.1 - 0.27 9.9 5.1 2.6 6.7 0.1 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Hid1 PF12722.2 CDI84142.1 - 0.47 8.0 8.6 1.2 6.7 3.2 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Spore_YhcN_YlaJ PF09580.5 CDI84142.1 - 0.49 10.4 9.6 5.9 6.9 3.3 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PMSI1 PF15322.1 CDI84142.1 - 0.54 9.2 13.2 0.067 12.2 4.4 2.1 2 0 0 2 2 2 0 Protein missing in infertile sperm 1, putative DUF1510 PF07423.6 CDI84142.1 - 0.76 9.1 17.7 0.2 10.9 7.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) FCP1_C PF09309.5 CDI84142.1 - 0.82 8.9 21.7 0.22 10.7 5.6 2.2 2 0 0 2 2 2 0 FCP1, C-terminal Hom_end_hint PF05203.11 CDI84142.1 - 0.84 9.3 6.3 1.3 8.6 1.7 2.1 2 0 0 2 2 2 0 Hom_end-associated Hint FHIPEP PF00771.15 CDI84142.1 - 1.1 7.4 10.4 2.1 6.5 0.6 2.2 2 0 0 2 2 2 0 FHIPEP family PH_4 PF15404.1 CDI84142.1 - 1.2 8.6 12.0 3.5 7.1 3.2 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DDHD PF02862.12 CDI84142.1 - 1.3 8.8 12.4 9.9 5.8 5.6 2.1 2 0 0 2 2 2 0 DDHD domain Pex16 PF08610.5 CDI84142.1 - 1.3 7.9 13.3 1 8.2 2.3 2.2 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) Ctr PF04145.10 CDI84142.1 - 1.7 8.6 10.3 2.8 7.9 0.9 2.3 2 0 0 2 2 2 0 Ctr copper transporter family DUF4557 PF15101.1 CDI84142.1 - 2 8.2 26.0 3.3 7.4 5.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) ATAD4 PF15321.1 CDI84142.1 - 2.1 9.4 16.3 7.8 7.5 4.4 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 FAM60A PF15396.1 CDI84142.1 - 2.2 7.9 9.0 1.5 8.4 1.2 2.2 2 0 0 2 2 2 0 Protein Family FAM60A DUF3371 PF11851.3 CDI84142.1 - 2.3 8.9 22.7 5.9 7.5 5.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) MAT1 PF06391.8 CDI84142.1 - 2.3 7.7 20.2 1.9 8.0 2.1 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 FLO_LFY PF01698.11 CDI84142.1 - 2.9 6.6 12.0 4.2 6.1 4.5 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein TraV PF09676.5 CDI84142.1 - 3.6 8.3 12.3 4.6 7.9 3.3 2.7 3 0 0 3 3 2 0 Type IV conjugative transfer system lipoprotein (TraV) DUF1764 PF08576.5 CDI84142.1 - 3.8 8.3 18.3 3.7 8.3 5.2 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DUF1669 PF07894.7 CDI84142.1 - 3.9 6.5 9.0 1.5 7.9 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1669) BRF1 PF07741.8 CDI84142.1 - 4.4 7.5 14.4 2.2 8.5 2.8 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Spore_coat_CotO PF14153.1 CDI84142.1 - 5.1 6.5 21.2 1.5 8.2 6.8 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Bud13 PF09736.4 CDI84142.1 - 6.4 7.0 22.4 1.6 8.9 7.0 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex CagX PF03524.10 CDI84142.1 - 6.7 5.9 13.3 1.4 8.1 0.7 2.2 2 0 0 2 2 2 0 Conjugal transfer protein LSM PF01423.17 CDI84144.1 - 3.7e-09 35.9 0.0 4.4e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CDI84144.1 - 0.0011 18.8 0.3 0.0023 17.7 0.2 1.5 1 1 0 1 1 1 1 Ataxin 2 SM domain LRR_1 PF00560.28 CDI84146.1 - 0.016 15.1 9.0 11 6.4 0.1 5.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.2 CDI84146.1 - 0.04 13.5 4.1 0.34 10.5 0.1 3.8 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) EDR1 PF14381.1 CDI84146.1 - 0.044 13.3 0.0 0.22 11.0 0.0 2.0 1 1 1 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 LRR_6 PF13516.1 CDI84146.1 - 0.34 11.1 11.7 33 4.9 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich repeat FimP PF09766.4 CDI84146.1 - 0.49 9.4 0.0 0.49 9.4 0.0 5.1 6 0 0 6 6 6 0 Fms-interacting protein DUF4114 PF13448.1 CDI84146.1 - 6.1 7.7 6.7 76 4.2 0.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4114) Spt20 PF12090.3 CDI84146.1 - 7.4 5.8 18.5 7.1 5.9 0.5 4.5 5 0 0 5 5 5 0 Spt20 family HCV_env PF01539.12 CDI84147.1 - 0.021 14.3 0.2 0.03 13.7 0.1 1.3 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 P30 PF07390.6 CDI84147.1 - 0.81 9.1 4.3 0.41 10.1 1.8 1.3 1 1 0 1 1 1 0 Mycoplasma P30 protein Dehydrin PF00257.14 CDI84147.1 - 1 9.6 9.0 5.2 7.3 0.0 3.0 3 0 0 3 3 3 0 Dehydrin DUF4618 PF15397.1 CDI84149.1 - 0.003 16.9 3.3 0.0039 16.5 2.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) TMPIT PF07851.8 CDI84149.1 - 0.041 12.9 1.4 0.047 12.7 1.0 1.0 1 0 0 1 1 1 0 TMPIT-like protein Phasin PF05597.6 CDI84149.1 - 0.045 13.5 4.6 0.067 12.9 3.2 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4407 PF14362.1 CDI84149.1 - 0.049 12.5 2.2 0.057 12.3 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.4 CDI84149.1 - 0.11 10.9 5.1 0.11 10.8 3.5 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF3584 PF12128.3 CDI84149.1 - 0.23 8.7 8.0 0.24 8.6 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NPV_P10 PF05531.7 CDI84149.1 - 0.26 11.5 2.1 0.33 11.2 0.6 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF2076 PF09849.4 CDI84149.1 - 0.54 10.2 3.7 1.5 8.8 2.6 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Spond_N PF06468.8 CDI84149.1 - 0.73 9.4 3.5 0.75 9.4 0.4 1.9 1 1 1 2 2 2 0 Spondin_N Myb_DNA-binding PF00249.26 CDI84150.1 - 1.7e-10 40.7 0.0 1.7e-06 28.0 0.0 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDI84150.1 - 2.1e-09 37.3 0.0 0.0011 19.0 0.0 3.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF247 PF03140.10 CDI84151.1 - 0.077 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function NifQ PF04891.7 CDI84152.1 - 0.027 14.6 0.6 0.027 14.6 0.4 2.6 2 1 1 3 3 3 0 NifQ DUF95 PF01944.12 CDI84152.1 - 0.057 13.0 1.1 0.1 12.2 0.5 1.7 1 1 0 1 1 1 0 Integral membrane protein DUF95 DUF4161 PF13722.1 CDI84152.1 - 0.085 13.1 0.8 0.19 12.0 0.5 1.6 1 1 0 1 1 1 0 C-terminal domain on CstA (DUF4161) SMAP PF15477.1 CDI84152.1 - 0.26 11.5 0.1 0.26 11.5 0.1 2.5 2 0 0 2 2 2 0 Small acidic protein family RED_N PF07808.8 CDI84152.1 - 1.3 8.1 6.2 1.1 8.3 2.5 1.9 2 0 0 2 2 2 0 RED-like protein N-terminal region Conotoxin PF02950.12 CDI84152.1 - 1.3 9.8 4.8 2.1 9.2 0.0 2.5 2 0 0 2 2 2 0 Conotoxin APC_CDC26 PF10471.4 CDI84152.1 - 3.5 8.4 19.8 5.3 7.8 0.7 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 DUF4010 PF13194.1 CDI84152.1 - 8.6 5.5 15.2 0.096 11.9 2.6 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4010) p25-alpha PF05517.7 CDI84153.1 - 2.6e-45 154.4 2.4 3.2e-45 154.1 1.7 1.0 1 0 0 1 1 1 1 p25-alpha SurA_N PF09312.6 CDI84153.1 - 0.047 13.5 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 SurA N-terminal domain Pkinase_Tyr PF07714.12 CDI84154.1 - 0.0023 17.0 0.6 0.0037 16.3 0.2 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Ribosomal_60s PF00428.14 CDI84154.1 - 0.015 15.6 4.4 0.015 15.6 3.1 6.3 5 2 1 6 6 6 0 60s Acidic ribosomal protein TFIIA PF03153.8 CDI84154.1 - 0.16 11.7 27.3 0.015 15.1 15.1 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 CDI84154.1 - 0.43 8.7 37.6 0.75 7.9 26.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DSHCT PF08148.7 CDI84155.1 - 2.7e-32 111.4 0.2 1.7e-30 105.5 0.2 2.4 1 1 0 1 1 1 1 DSHCT (NUC185) domain LMBR1 PF04791.11 CDI84156.1 - 1.7 7.1 3.3 1.8 7.0 0.1 2.3 3 0 0 3 3 3 0 LMBR1-like membrane protein PS_Dcarbxylase PF02666.10 CDI84158.1 - 2.4e-17 62.9 5.1 1.4e-12 47.3 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylserine decarboxylase DNA_primase_lrg PF04104.9 CDI84159.1 - 1.4e-51 175.3 0.0 8.9e-50 169.3 0.0 2.1 1 1 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Nanovirus_coat PF04660.7 CDI84159.1 - 0.085 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Nanovirus coat protein Rad17 PF03215.10 CDI84161.1 - 0.0011 17.7 0.0 0.0011 17.7 0.0 2.6 3 0 0 3 3 3 2 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 CDI84161.1 - 0.03 14.0 0.1 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PWI PF01480.12 CDI84162.1 - 6e-14 51.9 0.8 6e-14 51.9 0.5 2.3 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.17 CDI84162.1 - 5e-09 35.6 0.1 1.9e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.4 CDI84162.1 - 0.00072 19.0 9.6 0.00072 19.0 6.7 6.1 5 1 0 5 5 5 2 Nuclear RNA-splicing-associated protein DUF3647 PF12363.3 CDI84162.1 - 0.0053 16.8 0.7 0.19 11.8 0.1 2.5 2 0 0 2 2 2 1 Phage protein RRM_6 PF14259.1 CDI84162.1 - 0.028 14.3 0.0 0.089 12.7 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RNA_pol_Rpb6 PF01192.17 CDI84163.1 - 2.8e-18 65.3 0.1 4.3e-18 64.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 BAF1_ABF1 PF04684.8 CDI84166.1 - 0.00047 19.1 16.1 0.00047 19.1 11.2 12.7 6 3 5 12 12 12 2 BAF1 / ABF1 chromatin reorganising factor Peptidase_S49_N PF08496.5 CDI84168.1 - 0.014 15.2 0.8 0.014 15.2 0.6 5.5 5 1 1 6 6 6 0 Peptidase family S49 N-terminal C2 PF00168.25 CDI84170.1 - 2.6e-22 78.4 0.1 1.9e-07 30.8 0.0 4.5 4 1 0 4 4 4 3 C2 domain PTEN_C2 PF10409.4 CDI84170.1 - 0.048 13.3 0.0 1.6 8.4 0.0 2.9 3 0 0 3 3 3 0 C2 domain of PTEN tumour-suppressor protein FerI PF08151.7 CDI84170.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 FerI (NUC094) domain HOOK PF05622.7 CDI84171.1 - 0.024 12.4 11.6 0.036 11.9 8.0 1.1 1 0 0 1 1 1 0 HOOK protein TBPIP PF07106.8 CDI84171.1 - 0.1 12.1 5.8 0.17 11.4 4.0 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Adaptin_binding PF10199.4 CDI84171.1 - 0.46 10.7 8.4 0.86 9.8 5.4 1.7 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 ERM PF00769.14 CDI84171.1 - 4.3 6.7 18.1 0.46 9.9 9.5 1.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF342 PF03961.8 CDI84176.1 - 0.039 12.3 10.8 0.049 12.0 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Prominin PF05478.6 CDI84176.1 - 0.071 10.6 4.1 0.079 10.4 2.8 1.2 1 0 0 1 1 1 0 Prominin Synaptobrevin PF00957.16 CDI84176.1 - 0.58 9.7 4.0 1.3 8.7 2.8 1.6 1 0 0 1 1 1 0 Synaptobrevin CorA PF01544.13 CDI84176.1 - 1.1 8.1 4.3 1.6 7.6 3.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein PLRV_ORF5 PF01690.12 CDI84176.1 - 3.6 6.6 10.4 4 6.4 7.2 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Acetyltransf_1 PF00583.19 CDI84177.1 - 1e-11 44.7 0.1 1.8e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CDI84177.1 - 0.00052 19.7 0.1 0.00099 18.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 CDI84177.1 - 0.00063 19.8 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CDI84177.1 - 0.007 16.2 0.1 0.015 15.1 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDI84177.1 - 0.01 15.9 0.7 0.058 13.5 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Med3 PF11593.3 CDI84177.1 - 0.13 11.4 11.6 0.18 11.0 8.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pex14_N PF04695.8 CDI84178.1 - 2 8.4 9.9 6.4 6.8 0.8 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DOR PF14839.1 CDI84178.1 - 3.9 7.1 11.1 1.1 8.9 1.7 2.0 2 0 0 2 2 2 0 DOR family SR-25 PF10500.4 CDI84180.1 - 0.011 15.1 7.8 0.011 15.1 5.4 3.0 1 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein DUF1376 PF07120.6 CDI84180.1 - 0.14 12.2 0.6 0.48 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1376) zf-RING_UBOX PF13445.1 CDI84181.1 - 7e-06 25.6 1.0 2.7e-05 23.7 0.7 2.2 1 0 0 1 1 1 1 RING-type zinc-finger DUF2540 PF10802.3 CDI84181.1 - 1.7 8.3 0.0 3.1 7.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) DUF605 PF04652.11 CDI84182.1 - 0.32 10.3 28.8 0.4 10.0 20.0 1.1 1 0 0 1 1 1 0 Vta1 like W2 PF02020.13 CDI84184.1 - 1.7e-13 50.2 0.1 2.8e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon BAF1_ABF1 PF04684.8 CDI84185.1 - 0.00049 19.0 11.6 0.00049 19.0 8.1 11.0 12 1 0 12 12 12 2 BAF1 / ABF1 chromatin reorganising factor Utp13 PF08625.6 CDI84187.1 - 6.1e-14 51.8 3.6 6.1e-14 51.8 2.5 2.6 2 2 0 2 2 2 1 Utp13 specific WD40 associated domain Myco_19_kDa PF05481.7 CDI84187.1 - 5.5 6.7 6.0 0.42 10.4 0.1 2.0 3 0 0 3 3 3 0 Mycobacterium 19 kDa lipoprotein antigen DUF3824 PF12868.2 CDI84187.1 - 7.6 7.4 11.8 1.5 9.7 4.1 2.3 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) WD40 PF00400.27 CDI84189.1 - 3e-15 55.4 3.7 0.00021 21.0 0.0 6.0 5 1 1 6 6 6 3 WD domain, G-beta repeat DUF4184 PF13803.1 CDI84189.1 - 0.11 11.7 0.3 1.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4184) RRM_1 PF00076.17 CDI84190.1 - 3.7e-07 29.6 0.0 6.6e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI84190.1 - 4e-07 29.9 0.0 6.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI84190.1 - 1.7e-05 24.5 0.1 2.6e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 CDI84190.1 - 0.018 14.7 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ph1570 PF09638.5 CDI84190.1 - 0.034 13.9 0.0 0.11 12.2 0.0 1.7 1 1 1 2 2 2 0 Ph1570 protein Nup35_RRM_2 PF14605.1 CDI84190.1 - 0.052 13.3 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Smg4_UPF3 PF03467.10 CDI84190.1 - 0.071 13.0 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 Smg-4/UPF3 family SNF2_N PF00176.18 CDI84191.1 - 1.9e-16 59.7 0.0 2.4e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 CDI84191.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase DREPP PF05558.7 CDI84191.1 - 0.14 12.0 0.6 0.19 11.5 0.4 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Ribosomal_60s PF00428.14 CDI84193.1 - 4.2 7.8 13.1 0.48 10.8 3.1 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF4259 PF14078.1 CDI84195.1 - 0.11 13.0 0.4 0.11 13.0 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4259) DUF2803 PF10972.3 CDI84195.1 - 0.2 11.1 11.1 0.04 13.4 4.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2803) PAT1 PF09770.4 CDI84195.1 - 0.22 9.7 32.9 0.25 9.5 22.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3328 PF11807.3 CDI84199.1 - 0.16 11.6 0.1 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) RNA_pol_Rpb1_2 PF00623.15 CDI84200.1 - 1.9e-51 174.2 0.0 2e-33 115.6 0.0 2.7 2 0 0 2 2 2 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 CDI84200.1 - 1.8e-24 86.2 0.0 3e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.7 CDI84200.1 - 5e-13 49.0 6.6 1.7e-11 43.9 0.0 4.3 3 2 1 5 5 5 1 RNA polymerase Rpb1, domain 1 DUF4359 PF14271.1 CDI84200.1 - 0.57 10.5 5.8 0.22 11.8 0.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) Tmemb_9 PF05434.6 CDI84200.1 - 2.2 8.0 6.1 0.28 10.9 0.4 2.3 2 0 0 2 2 2 0 TMEM9 SNF2_N PF00176.18 CDI84201.1 - 4.9e-37 127.3 0.0 4.9e-37 127.3 0.0 4.6 4 1 0 5 5 5 1 SNF2 family N-terminal domain Bromodomain PF00439.20 CDI84201.1 - 1.6e-13 50.3 0.0 3.4e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.26 CDI84201.1 - 6.2e-07 29.2 2.3 6.6e-06 25.8 0.0 3.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Mem_trans PF03547.13 CDI84201.1 - 0.25 9.5 0.8 0.52 8.5 0.6 1.5 1 0 0 1 1 1 0 Membrane transport protein Adap_comp_sub PF00928.16 CDI84202.1 - 4.3e-82 275.1 0.0 5.3e-82 274.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 CDI84202.1 - 2.5e-05 24.0 0.1 4.8e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Rep_fac_C PF08542.6 CDI84202.1 - 0.054 13.4 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 Replication factor C C-terminal domain Med5 PF08689.5 CDI84202.1 - 0.058 11.0 0.0 0.071 10.7 0.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 Vac7 PF12751.2 CDI84203.1 - 0.015 14.2 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Mito_carr PF00153.22 CDI84204.1 - 2e-36 123.5 0.5 4.5e-12 45.5 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Kinase-like PF14531.1 CDI84205.1 - 2.8e-18 65.8 0.0 4.4e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.20 CDI84205.1 - 0.014 14.5 0.0 0.056 12.5 0.0 1.8 1 1 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84205.1 - 0.2 10.6 0.0 0.36 9.8 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase RabGAP-TBC PF00566.13 CDI84206.1 - 1.3e-31 109.7 4.8 1.9e-30 105.9 0.1 3.0 3 0 0 3 3 3 2 Rab-GTPase-TBC domain Phycoerythr_ab PF02972.9 CDI84206.1 - 0.043 13.4 0.5 0.12 11.9 0.4 1.7 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain DUF4407 PF14362.1 CDI84206.1 - 9.5 5.0 9.4 2.8 6.8 3.7 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Beta-lactamase PF00144.19 CDI84207.1 - 2.4e-42 145.1 0.3 1.5e-36 126.0 0.0 3.4 3 1 0 3 3 3 3 Beta-lactamase ABC1 PF03109.11 CDI84207.1 - 4.9e-24 84.5 0.0 9.9e-24 83.6 0.0 1.5 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.6 CDI84207.1 - 0.00044 19.5 0.0 0.00075 18.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) MFS_1 PF07690.11 CDI84210.1 - 1e-12 47.4 38.6 2.5e-08 33.0 19.7 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDI84210.1 - 4.5 5.5 24.7 0.1 11.0 4.9 3.0 3 0 0 3 3 3 0 MFS/sugar transport protein Pkinase PF00069.20 CDI84211.1 - 1.2e-22 80.3 0.0 1.9e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI84211.1 - 6.9e-21 74.4 0.0 9.6e-21 73.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 CDI84211.1 - 1e-06 28.0 0.0 4.1e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDI84211.1 - 0.13 11.9 0.2 0.38 10.4 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family KH_1 PF00013.24 CDI84212.1 - 8.1e-36 121.4 0.0 9.4e-10 37.9 0.1 5.2 5 0 0 5 5 5 4 KH domain KH_3 PF13014.1 CDI84212.1 - 2.1e-28 97.4 0.1 2.6e-07 30.1 0.2 5.3 5 0 0 5 5 5 4 KH domain KH_2 PF07650.12 CDI84212.1 - 0.0068 15.9 0.0 1 8.9 0.0 3.0 3 0 0 3 3 3 1 KH domain Mem_trans PF03547.13 CDI84212.1 - 0.059 11.6 0.0 0.059 11.6 0.0 2.2 1 1 1 2 2 2 0 Membrane transport protein DnaJ PF00226.26 CDI84213.1 - 7e-12 44.9 0.1 2.7e-11 43.0 0.1 2.2 1 1 0 1 1 1 1 DnaJ domain GTP_EFTU PF00009.22 CDI84214.1 - 3.8e-30 104.7 0.0 5.4e-28 97.7 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Shadoo PF14999.1 CDI84214.1 - 0.0013 18.5 0.8 0.0013 18.5 0.6 4.3 5 0 0 5 5 5 2 Shadow of prion protein, neuroprotective Miro PF08477.8 CDI84214.1 - 0.0022 18.4 0.0 0.36 11.3 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 CDI84214.1 - 0.0069 16.3 0.0 0.034 14.0 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase SR-25 PF10500.4 CDI84214.1 - 0.011 15.2 30.1 0.011 15.2 1.7 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Dynamin_N PF00350.18 CDI84214.1 - 0.02 14.7 1.3 0.12 12.1 0.0 2.9 3 1 0 3 3 3 0 Dynamin family Zip PF02535.17 CDI84214.1 - 0.065 12.2 4.4 0.26 10.2 0.0 2.8 3 0 0 3 3 3 0 ZIP Zinc transporter SAPS PF04499.10 CDI84214.1 - 0.35 9.4 4.8 0.95 8.0 0.2 2.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein RCC1 PF00415.13 CDI84215.1 - 1.7e-23 82.5 13.0 6.9e-08 32.5 0.2 7.6 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI84215.1 - 2.2e-18 65.3 34.0 7.2e-07 28.6 2.6 6.2 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat PIG-S PF10510.4 CDI84217.1 - 3.6e-09 35.8 0.0 7.5e-05 21.5 0.0 2.1 2 0 0 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein DUF3712 PF12505.3 CDI84218.1 - 7.7e-30 103.4 3.9 4.3e-12 46.1 0.0 8.2 8 0 0 8 8 8 6 Protein of unknown function (DUF3712) OmpH PF03938.9 CDI84218.1 - 0.00015 21.7 7.4 0.00015 21.7 5.1 5.3 4 1 0 4 4 4 2 Outer membrane protein (OmpH-like) PBP1_TM PF14812.1 CDI84218.1 - 5.3 7.4 0.0 5.3 7.4 0.0 6.9 7 0 0 7 7 7 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PIP5K PF01504.13 CDI84219.1 - 5.2e-25 87.9 0.0 3.6e-22 78.6 0.0 2.4 2 0 0 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase FYVE PF01363.16 CDI84219.1 - 2.3e-14 53.0 13.4 2.3e-14 53.0 9.3 2.4 2 0 0 2 2 2 1 FYVE zinc finger Cpn60_TCP1 PF00118.19 CDI84219.1 - 0.094 11.3 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family COPI_assoc PF08507.5 CDI84223.1 - 2.7e-12 46.5 4.9 3.3e-12 46.2 3.4 1.1 1 0 0 1 1 1 1 COPI associated protein Oxidored_q2 PF00420.19 CDI84223.1 - 0.2 11.3 4.0 3.2 7.3 0.0 2.2 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF3096 PF11295.3 CDI84223.1 - 2.5 7.6 6.4 0.28 10.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3096) Peptidase_C65 PF10275.4 CDI84225.1 - 2e-53 181.2 0.0 2.4e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.14 CDI84225.1 - 2.2e-05 25.0 0.0 0.00085 19.9 0.0 2.4 1 1 0 1 1 1 1 OTU-like cysteine protease DUF935 PF06074.7 CDI84225.1 - 0.11 11.2 1.0 0.26 9.9 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF935) DUF3336 PF11815.3 CDI84225.1 - 0.11 11.9 0.0 0.29 10.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) Ribosomal_60s PF00428.14 CDI84225.1 - 0.13 12.6 9.9 0.14 12.5 5.3 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein mTERF PF02536.9 CDI84226.1 - 5e-11 41.7 0.1 1e-08 34.1 0.0 2.2 2 0 0 2 2 2 2 mTERF DUF3395 PF11875.3 CDI84226.1 - 1.2 8.7 0.0 1.2 8.7 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3395) IF-2B PF01008.12 CDI84227.1 - 5.6e-15 55.0 5.6 8.2e-10 38.1 0.0 3.2 2 1 0 3 3 3 2 Initiation factor 2 subunit family Spt20 PF12090.3 CDI84227.1 - 0.0048 16.2 0.1 0.0048 16.2 0.0 3.0 2 1 0 2 2 1 1 Spt20 family Lon_2 PF13337.1 CDI84227.1 - 0.014 13.7 0.0 0.014 13.7 0.0 1.6 2 0 0 2 2 1 0 Putative ATP-dependent Lon protease DUF4557 PF15101.1 CDI84227.1 - 0.017 15.0 2.2 0.017 15.0 1.5 3.4 2 1 1 3 3 1 0 Domain of unknown function (DUF4557) Med15 PF09606.5 CDI84227.1 - 0.04 12.1 84.3 0.0069 14.6 40.0 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.11 CDI84227.1 - 2.3 8.0 15.1 15 5.3 0.0 2.9 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Band_3_cyto PF07565.8 CDI84227.1 - 3.4 7.0 23.1 0.2 11.1 0.2 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Spore_coat_CotO PF14153.1 CDI84227.1 - 4 6.8 26.9 0.6 9.5 9.5 2.3 2 0 0 2 2 2 0 Spore coat protein CotO HlyD_2 PF12700.2 CDI84227.1 - 6.2 5.8 16.7 2.1 7.4 8.2 2.0 2 0 0 2 2 2 0 HlyD family secretion protein PLRV_ORF5 PF01690.12 CDI84227.1 - 6.8 5.7 21.4 2.6 7.0 9.8 2.1 2 0 0 2 2 2 0 Potato leaf roll virus readthrough protein Gti1_Pac2 PF09729.4 CDI84227.1 - 8.7 6.1 11.3 29 4.4 0.0 3.0 3 0 0 3 3 3 0 Gti1/Pac2 family ARS2 PF04959.8 CDI84228.1 - 1.3e-05 25.5 0.1 1.9e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.1 CDI84228.1 - 2e-05 24.0 0.1 4.6e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) PocR PF10114.4 CDI84228.1 - 0.024 13.8 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR DUF1777 PF08648.7 CDI84228.1 - 0.48 10.1 15.6 0.044 13.5 7.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) zf-C2H2 PF00096.21 CDI84228.1 - 0.65 10.4 5.9 2 8.9 4.1 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type PRP38_assoc PF12871.2 CDI84228.1 - 1.4 9.4 21.1 2 8.9 10.7 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Pkinase PF00069.20 CDI84231.1 - 8.9e-14 51.2 0.0 8.9e-14 51.2 0.0 3.8 2 2 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84231.1 - 4.3e-07 29.2 0.0 4.3e-07 29.2 0.0 2.6 2 1 1 3 3 3 1 Protein tyrosine kinase Thioredoxin PF00085.15 CDI84233.1 - 3.7e-26 90.8 0.0 4.6e-13 48.7 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.1 CDI84233.1 - 2.2e-08 34.1 0.0 1.2e-07 31.7 0.0 2.1 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 CDI84233.1 - 2.1e-06 27.6 0.0 0.038 13.9 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 CDI84233.1 - 0.0011 19.0 0.0 1.6 8.8 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Med15 PF09606.5 CDI84233.1 - 0.0049 15.1 145.9 0.0097 14.1 101.1 1.4 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Thioredoxin_2 PF13098.1 CDI84233.1 - 0.13 12.4 0.0 0.13 12.4 0.0 3.7 3 1 0 3 3 3 0 Thioredoxin-like domain tRNA-synt_1 PF00133.17 CDI84236.1 - 6.7e-100 334.8 1.6 2.7e-71 240.3 0.0 2.3 2 1 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 CDI84236.1 - 9.2e-11 41.3 0.0 2.7e-08 33.3 0.0 2.4 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 CDI84236.1 - 2.5e-10 39.5 0.0 1.6e-09 36.8 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1d PF00750.14 CDI84236.1 - 0.0071 15.2 0.1 0.021 13.6 0.0 1.6 1 1 0 2 2 2 1 tRNA synthetases class I (R) T2SI PF02501.12 CDI84236.1 - 0.028 14.3 0.2 0.071 13.0 0.1 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I Proteasome_A_N PF10584.4 CDI84236.1 - 0.032 13.5 0.0 0.059 12.6 0.0 1.5 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature DUF3201 PF11447.3 CDI84236.1 - 0.043 13.2 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) tRNA-synt_1c PF00749.16 CDI84236.1 - 0.049 12.2 0.0 0.096 11.3 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DNA_pack_C PF02499.10 CDI84236.1 - 0.12 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Probable DNA packing protein, C-terminus 4HBT PF03061.17 CDI84237.1 - 0.00077 19.5 6.8 0.014 15.5 0.1 3.2 4 0 0 4 4 4 2 Thioesterase superfamily Pkinase PF00069.20 CDI84238.1 - 6e-16 58.3 0.0 6.9e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84238.1 - 0.15 11.0 0.0 0.33 9.9 0.0 1.7 1 1 0 1 1 1 0 Protein tyrosine kinase AAA_16 PF13191.1 CDI84239.1 - 3.3e-05 23.9 2.6 3.3e-05 23.9 1.8 3.0 3 1 0 3 3 3 1 AAA ATPase domain Arch_ATPase PF01637.13 CDI84239.1 - 0.0006 19.5 0.0 0.014 15.0 0.0 2.6 3 0 0 3 3 3 1 Archaeal ATPase AAA_19 PF13245.1 CDI84239.1 - 0.0093 15.7 0.0 0.0093 15.7 0.0 3.4 2 1 1 3 3 3 1 Part of AAA domain AAA_35 PF14516.1 CDI84239.1 - 0.035 12.7 1.4 0.89 8.1 0.0 2.6 3 0 0 3 3 3 0 AAA-like domain AAA_25 PF13481.1 CDI84239.1 - 0.056 12.8 1.3 0.24 10.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 CDI84239.1 - 0.072 13.2 0.5 0.59 10.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain Metallophos PF00149.23 CDI84240.1 - 4.4e-31 107.8 0.1 5.8e-31 107.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDI84240.1 - 0.0086 15.9 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PAP_central PF04928.12 CDI84245.1 - 1.1e-49 168.6 0.0 1e-27 96.5 0.0 2.3 1 1 1 2 2 2 2 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 CDI84245.1 - 7.6e-17 61.2 0.0 1.5e-15 57.0 0.0 2.6 1 1 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 CDI84245.1 - 1.3e-07 31.8 0.0 2.4e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain RskA PF10099.4 CDI84246.1 - 0.014 15.1 7.0 0.014 15.1 4.9 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Suf PF05843.9 CDI84246.1 - 0.046 13.4 28.2 0.49 10.0 13.5 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Med15 PF09606.5 CDI84246.1 - 0.38 8.8 60.2 0.66 8.1 27.8 2.0 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SprA-related PF12118.3 CDI84246.1 - 0.61 9.3 61.8 0.095 12.0 27.0 2.0 2 0 0 2 2 2 0 SprA-related family Zip PF02535.17 CDI84246.1 - 0.64 8.9 11.0 0.13 11.2 3.7 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter SSP160 PF06933.6 CDI84246.1 - 0.75 7.7 11.9 0.94 7.3 8.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CD20 PF04103.10 CDI84246.1 - 2 8.3 13.7 0.23 11.3 1.5 2.9 3 0 0 3 3 3 0 CD20-like family P30 PF07390.6 CDI84246.1 - 2.1 7.7 6.1 2.7 7.4 4.2 1.1 1 0 0 1 1 1 0 Mycoplasma P30 protein RAP1 PF07218.6 CDI84246.1 - 3.7 5.5 9.7 4.7 5.1 6.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ribosomal_60s PF00428.14 CDI84246.1 - 4.2 7.8 11.4 0.83 10.0 2.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein AAA_23 PF13476.1 CDI84246.1 - 4.2 7.6 19.9 0.075 13.3 5.0 2.1 2 0 0 2 2 2 0 AAA domain DUF4175 PF13779.1 CDI84246.1 - 4.6 4.8 46.1 0.18 9.4 17.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) DUF4259 PF14078.1 CDI84246.1 - 4.9 7.6 8.5 1.6 9.2 2.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) Corona_nucleoca PF00937.13 CDI84246.1 - 6 5.7 31.3 0.28 10.0 13.8 2.0 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein Flu_M2 PF00599.12 CDI84247.1 - 0.28 10.9 0.2 6.2 6.6 0.1 3.2 2 0 0 2 2 2 0 Influenza Matrix protein (M2) Pex24p PF06398.6 CDI84247.1 - 2.8 6.6 3.3 22 3.7 0.6 2.5 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin PRA1 PF03208.14 CDI84247.1 - 3.2 7.0 6.0 0.8 9.0 1.3 2.1 2 0 0 2 2 2 0 PRA1 family protein LMBR1 PF04791.11 CDI84248.1 - 3 6.3 3.7 5.5 5.4 2.6 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF2638 PF10937.3 CDI84250.1 - 1.5 9.9 5.6 1.9 9.5 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2638) Med7 PF05983.6 CDI84251.1 - 7.4e-06 25.8 27.9 0.00025 20.8 19.3 2.5 1 1 0 1 1 1 1 MED7 protein SPX PF03105.14 CDI84251.1 - 0.00039 20.3 14.6 0.00058 19.7 10.1 1.2 1 0 0 1 1 1 1 SPX domain CDC45 PF02724.9 CDI84251.1 - 0.47 8.4 20.2 0.69 7.8 14.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 CDI84251.1 - 2 6.0 18.9 3.1 5.3 13.1 1.2 1 0 0 1 1 1 0 Ycf1 DUF4647 PF15504.1 CDI84251.1 - 2.5 6.8 27.3 0.75 8.5 16.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Ribosomal_60s PF00428.14 CDI84251.1 - 2.6 8.5 12.0 5 7.5 8.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Raftlin PF15250.1 CDI84251.1 - 5.2 5.4 20.7 10 4.5 14.3 1.4 1 0 0 1 1 1 0 Raftlin DUF544 PF04424.8 CDI84252.1 - 1.7e-16 60.0 0.0 1.7e-16 60.0 0.0 5.4 5 4 0 5 5 5 1 Protein of unknown function (DUF544) Ldh_1_N PF00056.18 CDI84253.1 - 2.4e-37 127.9 1.2 4e-37 127.1 0.3 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CDI84253.1 - 1.8e-31 109.1 0.0 2.9e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.11 CDI84253.1 - 0.0001 21.6 0.5 0.0037 16.6 0.0 2.6 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase 3Beta_HSD PF01073.14 CDI84253.1 - 0.056 12.1 0.0 0.1 11.2 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family RNA_pol_Rpb2_6 PF00562.23 CDI84257.1 - 2.3e-46 158.2 0.0 2.8e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.15 CDI84257.1 - 3.1e-31 107.4 0.1 4.6e-31 106.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 TBP PF00352.16 CDI84258.1 - 5.9e-11 41.5 0.0 3.5e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) HCV_NS2 PF01538.13 CDI84258.1 - 0.035 13.5 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 DUF1126 PF06565.7 CDI84259.1 - 2.5e-11 42.8 0.9 0.0002 20.7 0.0 3.3 3 0 0 3 3 3 2 Repeat of unknown function (DUF1126) MurB_C PF02873.11 CDI84260.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain AAA PF00004.24 CDI84262.1 - 6.9e-41 139.5 0.0 1e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI84262.1 - 4.4e-07 30.1 0.0 7.4e-05 22.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CDI84262.1 - 7.1e-06 25.7 0.1 0.00012 21.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDI84262.1 - 0.00014 21.9 0.1 0.00053 20.0 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 CDI84262.1 - 0.0002 22.1 0.0 0.00033 21.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDI84262.1 - 0.00074 19.2 0.1 0.0019 17.9 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_2 PF07724.9 CDI84262.1 - 0.00098 19.0 0.1 0.0029 17.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 CDI84262.1 - 0.0011 18.1 0.0 0.0018 17.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CDI84262.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CDI84262.1 - 0.013 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDI84262.1 - 0.016 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 CDI84262.1 - 0.02 13.7 0.0 0.048 12.5 0.0 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 CDI84262.1 - 0.022 13.8 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF815 PF05673.8 CDI84262.1 - 0.024 13.5 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.1 CDI84262.1 - 0.031 14.1 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 CDI84262.1 - 0.035 13.6 0.1 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CDI84262.1 - 0.044 13.1 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 CDI84262.1 - 0.045 12.9 0.0 0.098 11.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 CDI84262.1 - 0.064 11.9 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_11 PF13086.1 CDI84262.1 - 0.081 12.4 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 CDI84262.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.21 CDI84262.1 - 0.11 11.9 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.17 CDI84262.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DUF1501 PF07394.7 CDI84263.1 - 0.76 8.5 4.7 1.3 7.8 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Pol_alpha_B_N PF08418.5 CDI84263.1 - 9.3 5.6 13.0 19 4.7 9.0 1.6 1 1 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Metallophos PF00149.23 CDI84264.1 - 7.5e-14 51.5 0.1 1.2e-13 50.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDI84264.1 - 3.4e-06 26.9 0.0 8.8e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ribosomal_L3 PF00297.17 CDI84268.1 - 1.9e-21 76.6 3.0 4.7e-20 72.0 2.1 2.5 1 1 0 1 1 1 1 Ribosomal protein L3 Pex14_N PF04695.8 CDI84268.1 - 0.045 13.7 3.7 0.056 13.4 1.1 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sec3_C PF09763.4 CDI84268.1 - 0.22 9.6 0.9 0.33 9.0 0.7 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 Apt1 PF10351.4 CDI84268.1 - 1.2 7.9 6.7 1.7 7.4 4.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RNA_pol_N PF01194.12 CDI84270.1 - 3.8e-32 110.1 0.5 4.6e-32 109.8 0.3 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Thioredoxin PF00085.15 CDI84271.1 - 3.6e-29 100.4 0.6 4.2e-29 100.2 0.4 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 CDI84271.1 - 6.3e-06 26.3 0.7 6.7e-05 23.0 0.5 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDI84271.1 - 1.1e-05 25.4 0.1 2.4e-05 24.3 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like Glutaredoxin PF00462.19 CDI84271.1 - 0.00017 21.5 0.1 0.00022 21.1 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.1 CDI84271.1 - 0.00071 19.1 0.0 0.00071 19.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin KaiB PF07689.7 CDI84271.1 - 0.0015 17.9 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 KaiB domain Thioredoxin_7 PF13899.1 CDI84271.1 - 0.013 15.4 0.1 0.018 15.0 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.5 CDI84271.1 - 0.022 14.2 0.9 0.064 12.8 0.6 1.8 1 1 0 1 1 1 0 Redoxin AhpC-TSA PF00578.16 CDI84271.1 - 0.022 14.4 0.1 0.028 14.1 0.1 1.2 1 0 0 1 1 1 0 AhpC/TSA family NST1 PF13945.1 CDI84272.1 - 0.011 15.8 20.4 0.011 15.8 14.1 4.1 1 1 3 4 4 4 0 Salt tolerance down-regulator DUF3729 PF12526.3 CDI84273.1 - 1.7 10.0 9.3 2.5 9.5 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3729) ASFV_J13L PF05568.6 CDI84273.1 - 8.2 5.9 10.7 13 5.2 7.4 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein Zip PF02535.17 CDI84276.1 - 8.3e-32 110.4 8.4 2.2e-30 105.7 5.9 2.8 1 1 0 1 1 1 1 ZIP Zinc transporter DUF912 PF06024.7 CDI84276.1 - 0.031 14.3 0.7 1 9.4 0.0 2.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) APC_CDC26 PF10471.4 CDI84277.1 - 3.5 8.4 11.8 9.9 6.9 8.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 SR-25 PF10500.4 CDI84277.1 - 9.4 5.6 20.9 15 4.9 14.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HNF-1_N PF04814.8 CDI84278.1 - 1.3 9.0 7.4 1.6 8.7 5.1 1.0 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus PBP1_TM PF14812.1 CDI84278.1 - 2 8.7 20.4 34 4.8 14.2 2.2 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PRP3 PF08572.5 CDI84278.1 - 2.4 7.4 7.3 2.7 7.3 5.1 1.1 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) Daxx PF03344.10 CDI84278.1 - 3.9 5.8 19.6 4.4 5.6 13.6 1.1 1 0 0 1 1 1 0 Daxx Family Bd3614_N PF14442.1 CDI84278.1 - 4 7.4 8.3 5.3 7.0 5.7 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Med17 PF10156.4 CDI84278.1 - 6.3 4.9 10.6 6.9 4.8 7.4 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex DUF2457 PF10446.4 CDI84278.1 - 9 4.8 29.7 11 4.5 20.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DJ-1_PfpI PF01965.19 CDI84279.1 - 4e-26 91.2 0.0 5.7e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 CDI84279.1 - 3.4e-13 49.1 0.0 5.8e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Putative amidotransferase DUF4557 PF15101.1 CDI84280.1 - 0.015 15.1 5.4 0.015 15.1 3.8 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4557) Sec3_C PF09763.4 CDI84282.1 - 0.067 11.3 2.1 0.065 11.3 1.5 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 SpoIIIAH PF12685.2 CDI84282.1 - 0.31 10.5 4.0 0.079 12.4 0.5 1.6 2 0 0 2 2 2 0 SpoIIIAH-like protein Corona_nucleoca PF00937.13 CDI84282.1 - 2.2 7.1 20.4 3 6.6 14.1 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Rifin_STEVOR PF02009.11 CDI84282.1 - 8.8 5.8 14.4 14 5.1 10.0 1.4 1 1 0 1 1 1 0 Rifin/stevor family DUF1768 PF08719.6 CDI84286.1 - 6.3e-17 61.7 0.0 1.2e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) RRM_1 PF00076.17 CDI84286.1 - 2.1e-14 52.9 0.0 1.7e-13 49.9 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI84286.1 - 8.5e-12 44.8 0.0 2e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FHA PF00498.21 CDI84286.1 - 1.8e-10 40.8 0.0 6.6e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 FHA domain RRM_5 PF13893.1 CDI84286.1 - 3.1e-09 36.5 0.0 1e-08 34.9 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 CDI84286.1 - 0.0099 15.6 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif WD40 PF00400.27 CDI84288.1 - 4.7e-23 80.1 12.5 1.5e-06 27.8 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat Ribosomal_S24e PF01282.14 CDI84290.1 - 2e-23 81.9 0.0 3.7e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e Ribosomal_L1 PF00687.16 CDI84291.1 - 3e-47 160.8 4.6 3.6e-47 160.5 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF1676 PF07898.8 CDI84291.1 - 0.095 13.0 0.0 0.29 11.4 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1676) U3snoRNP10 PF12397.3 CDI84291.1 - 0.15 12.0 0.9 0.35 10.8 0.1 2.0 2 1 0 2 2 2 0 U3 small nucleolar RNA-associated protein 10 HUN PF08729.5 CDI84293.1 - 0.00048 19.9 2.9 0.001 18.9 2.0 1.5 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Gly-zipper_OmpA PF13436.1 CDI84293.1 - 0.001 18.7 9.5 0.001 18.7 6.6 1.7 2 0 0 2 2 2 1 Glycine-zipper containing OmpA-like membrane domain DUF1308 PF07000.6 CDI84293.1 - 0.015 13.9 0.4 3.5 6.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) RRM_1 PF00076.17 CDI84302.1 - 0.00098 18.7 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI84302.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI84302.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FimP PF09766.4 CDI84303.1 - 8.5e-05 21.7 26.9 0.00011 21.3 10.3 2.2 2 0 0 2 2 2 2 Fms-interacting protein Gag_spuma PF03276.9 CDI84303.1 - 0.0021 16.4 16.3 0.0021 16.4 11.3 2.0 2 0 0 2 2 2 1 Spumavirus gag protein Pex14_N PF04695.8 CDI84303.1 - 0.0067 16.4 19.9 0.085 12.9 9.2 2.4 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region RP-C_C PF11800.3 CDI84303.1 - 0.048 13.3 20.2 0.052 13.2 6.1 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region FAM176 PF14851.1 CDI84303.1 - 0.065 12.9 12.5 0.4 10.3 0.4 2.2 2 0 0 2 2 2 0 FAM176 family Pex26 PF07163.7 CDI84303.1 - 0.07 12.0 20.4 0.3 9.9 2.2 2.1 2 0 0 2 2 2 0 Pex26 protein PAT1 PF09770.4 CDI84303.1 - 0.092 10.9 41.7 0.11 10.7 28.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SAPS PF04499.10 CDI84303.1 - 0.17 10.5 13.4 0.21 10.1 9.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1510 PF07423.6 CDI84303.1 - 0.2 11.0 20.7 0.37 10.1 8.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) RED_N PF07808.8 CDI84303.1 - 0.43 9.7 23.6 0.14 11.3 8.2 2.3 2 0 0 2 2 2 0 RED-like protein N-terminal region Folate_carrier PF01770.13 CDI84303.1 - 0.48 8.8 9.6 0.53 8.7 2.4 2.1 2 0 0 2 2 2 0 Reduced folate carrier DUF2052 PF09747.4 CDI84303.1 - 0.54 10.1 29.9 0.7 9.7 2.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) YqfQ PF14181.1 CDI84303.1 - 0.61 10.1 22.6 2.8 7.9 0.9 2.2 2 0 0 2 2 2 0 YqfQ-like protein Prothymosin PF03247.9 CDI84303.1 - 0.68 10.1 23.5 0.2 11.7 1.9 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family TRAP_alpha PF03896.11 CDI84303.1 - 0.76 8.7 9.0 0.28 10.1 1.8 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Hid1 PF12722.2 CDI84303.1 - 1.2 6.7 16.5 1.6 6.2 11.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1764 PF08576.5 CDI84303.1 - 1.4 9.7 21.7 7.6 7.3 0.6 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) CRT10 PF08728.5 CDI84303.1 - 1.6 6.6 8.3 1.9 6.4 5.8 1.0 1 0 0 1 1 1 0 CRT10 DUF3408 PF11888.3 CDI84303.1 - 1.7 8.6 17.8 5.4 6.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF3260 PF11658.3 CDI84303.1 - 2 6.4 12.4 0.52 8.3 3.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3260) Serinc PF03348.10 CDI84303.1 - 2.1 6.9 15.4 0.48 9.0 4.6 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) SpoVR PF04293.8 CDI84303.1 - 2.6 6.3 15.0 0.35 9.1 4.8 2.1 2 0 0 2 2 2 0 SpoVR like protein DUF4407 PF14362.1 CDI84303.1 - 3 6.7 32.6 4.2 6.2 22.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ATAD4 PF15321.1 CDI84303.1 - 3.2 8.8 18.3 8.4 7.4 0.7 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 AvrE PF11725.3 CDI84303.1 - 3.3 4.6 23.8 3.7 4.4 16.5 1.1 1 0 0 1 1 1 0 Pathogenicity factor SID-1_RNA_chan PF13965.1 CDI84303.1 - 4 5.4 9.4 1.1 7.3 2.0 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 SeqA PF03925.8 CDI84303.1 - 7.4 6.2 26.0 0.09 12.4 2.4 2.2 1 1 1 2 2 2 0 SeqA protein RNA_pol_Rbc25 PF08292.7 CDI84306.1 - 3.9e-16 59.3 0.0 2.7e-12 46.9 0.0 2.1 2 0 0 2 2 2 2 RNA polymerase III subunit Rpc25 N6_N4_Mtase PF01555.13 CDI84307.1 - 0.0023 17.4 0.0 48 3.3 0.0 4.2 3 2 0 3 3 3 1 DNA methylase Nha1_C PF08619.5 CDI84307.1 - 0.0032 16.7 3.9 0.0032 16.7 2.7 6.3 5 1 0 6 6 6 2 Alkali metal cation/H+ antiporter Nha1 C terminus GTP_EFTU PF00009.22 CDI84308.1 - 1.9e-42 144.8 0.0 3.7e-34 117.7 0.0 2.7 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain EFG_C PF00679.19 CDI84308.1 - 1.5e-10 40.7 0.0 8e-10 38.4 0.0 2.2 1 1 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 CDI84308.1 - 5e-06 26.2 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 CDI84308.1 - 0.091 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AIG1 PF04548.11 CDI84308.1 - 0.47 9.5 0.0 0.47 9.5 0.0 3.3 6 0 0 6 6 6 0 AIG1 family Peptidase_S28 PF05577.7 CDI84309.1 - 1.3e-31 109.6 7.3 7.5e-24 84.0 0.0 3.2 1 1 2 3 3 3 3 Serine carboxypeptidase S28 SR-25 PF10500.4 CDI84309.1 - 0.00046 19.7 11.8 0.0011 18.5 8.2 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Abhydrolase_6 PF12697.2 CDI84309.1 - 0.00052 19.9 1.3 0.0012 18.7 0.4 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family PRP38_assoc PF12871.2 CDI84309.1 - 0.039 14.4 13.0 0.079 13.5 9.0 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3446 PF11928.3 CDI84309.1 - 0.95 9.6 10.8 0.22 11.7 5.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) Apis_Csd PF11671.3 CDI84309.1 - 0.99 9.1 4.8 2.7 7.8 3.3 1.7 1 0 0 1 1 1 0 Complementary sex determiner protein BAF1_ABF1 PF04684.8 CDI84309.1 - 6.4 5.4 7.3 6.1 5.5 1.2 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Neur_chan_memb PF02932.11 CDI84310.1 - 0.00029 20.7 2.4 0.00043 20.2 1.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF755 PF05501.6 CDI84310.1 - 0.0012 18.9 5.7 0.0012 18.9 4.0 2.9 2 1 1 3 3 2 1 Domain of unknown function (DUF755) Suf PF05843.9 CDI84310.1 - 0.0019 18.0 2.9 0.0019 18.0 2.0 2.1 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) TFIIA PF03153.8 CDI84310.1 - 0.0036 17.2 17.9 0.0051 16.7 12.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1191 PF06697.7 CDI84310.1 - 0.0053 15.6 0.1 0.012 14.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) BUD22 PF09073.5 CDI84310.1 - 0.02 13.9 0.0 0.02 13.9 0.0 2.1 2 0 0 2 2 2 0 BUD22 FUSC PF04632.7 CDI84310.1 - 0.1 10.9 14.8 0.14 10.5 10.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2615 PF11027.3 CDI84310.1 - 0.28 11.1 5.3 7.8 6.4 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) FAM60A PF15396.1 CDI84310.1 - 0.37 10.4 9.9 1.2 8.8 0.8 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Calc_CGRP_IAPP PF00214.14 CDI84310.1 - 1.1 9.2 15.9 0.61 10.1 5.3 2.2 2 0 0 2 2 2 0 Calcitonin / CGRP / IAPP family CDK5_activator PF03261.10 CDI84310.1 - 1.5 8.1 12.9 0.093 12.0 2.0 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein DUF572 PF04502.8 CDI84310.1 - 2 7.5 20.8 3 6.9 14.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Shisa PF13908.1 CDI84310.1 - 2.1 8.4 11.3 0.17 12.0 0.7 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Ndc1_Nup PF09531.5 CDI84310.1 - 2.8 6.2 9.2 3.9 5.7 6.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NST1 PF13945.1 CDI84310.1 - 3.7 7.5 19.0 4.5 7.2 3.9 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator Tmemb_9 PF05434.6 CDI84310.1 - 5.9 6.6 12.7 1.7 8.3 4.2 2.1 2 0 0 2 2 2 0 TMEM9 CLPTM1 PF05602.7 CDI84310.1 - 6.7 5.3 7.0 10 4.7 4.7 1.3 1 1 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Golgin_A5 PF09787.4 CDI84311.1 - 0.00029 19.4 10.9 0.00029 19.4 7.6 2.0 2 0 0 2 2 2 1 Golgin subfamily A member 5 RAP1 PF07218.6 CDI84311.1 - 1.4 6.8 15.1 2 6.4 10.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF243 PF03103.12 CDI84311.1 - 6.1 7.0 9.4 7.3 6.7 4.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF243) Band_7 PF01145.20 CDI84314.1 - 1.2e-08 35.0 0.0 1.2e-08 35.0 0.0 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 CDI84314.1 - 0.033 13.6 0.0 0.071 12.6 0.0 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family Arf PF00025.16 CDI84315.1 - 5.8e-30 103.8 0.0 7.6e-30 103.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CDI84315.1 - 0.00015 21.1 0.0 0.0002 20.7 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 CDI84315.1 - 0.001 18.3 0.0 0.012 14.8 0.0 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 CDI84315.1 - 0.0042 17.5 0.0 0.0081 16.6 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein 2OG-FeII_Oxy_3 PF13640.1 CDI84318.1 - 0.00017 22.0 0.1 0.00036 20.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 CDI84318.1 - 0.00023 21.4 0.0 0.0004 20.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 CDI84318.1 - 0.032 13.8 0.2 0.068 12.8 0.1 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Cytochrom_B561 PF03188.11 CDI84320.1 - 0.00027 20.7 0.2 0.061 13.1 0.2 2.6 1 1 1 2 2 2 2 Eukaryotic cytochrome b561 PP2C PF00481.16 CDI84321.1 - 2.1e-37 128.8 0.2 7.9e-26 90.9 0.0 3.9 4 1 0 4 4 4 3 Protein phosphatase 2C zf-RanBP PF00641.13 CDI84323.1 - 2.5e-15 55.2 20.0 1.2e-09 37.1 3.3 2.2 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-P11 PF03854.9 CDI84323.1 - 0.0093 15.4 4.1 0.41 10.1 0.1 2.2 2 0 0 2 2 2 2 P-11 zinc finger PHD_3 PF13922.1 CDI84323.1 - 0.21 11.8 4.3 16 5.8 3.1 2.4 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx DZR PF12773.2 CDI84323.1 - 0.36 10.6 7.1 1.8 8.4 4.9 2.1 1 1 0 1 1 1 0 Double zinc ribbon eIF-3_zeta PF05091.7 CDI84323.1 - 1.7 7.1 5.3 2.2 6.7 3.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TF_Zn_Ribbon PF08271.7 CDI84324.1 - 0.11 11.8 0.5 0.2 10.9 0.4 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding LEF-8 PF04941.7 CDI84324.1 - 3.5 5.1 0.3 5.2 4.6 0.2 1.1 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) AP2 PF00847.15 CDI84326.1 - 5.1e-05 23.3 6.7 5.1e-05 23.3 4.7 6.1 6 0 0 6 6 6 2 AP2 domain PAT1 PF09770.4 CDI84326.1 - 1.6 6.8 95.9 2 6.5 45.5 2.3 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 14-3-3 PF00244.15 CDI84329.1 - 4.1e-09 35.8 0.1 1.3e-08 34.2 0.0 1.7 2 0 0 2 2 2 1 14-3-3 protein PALP PF00291.20 CDI84330.1 - 1.4e-47 162.4 1.7 1.4e-47 162.4 1.2 1.5 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme L27 PF02828.11 CDI84332.1 - 4.5 7.0 10.3 45 3.8 0.6 3.7 3 0 0 3 3 3 0 L27 domain mRNA_cap_enzyme PF01331.14 CDI84333.1 - 6.5e-24 84.6 0.7 5.5e-09 35.9 0.0 3.4 2 1 2 4 4 4 3 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.16 CDI84333.1 - 0.0048 16.2 1.1 0.91 8.8 0.0 2.2 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Halogen_Hydrol PF10112.4 CDI84334.1 - 0.0037 16.7 0.0 0.008 15.6 0.0 1.5 1 0 0 1 1 1 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein Suf PF05843.9 CDI84334.1 - 0.34 10.5 9.7 0.57 9.8 6.8 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Bap31 PF05529.7 CDI84334.1 - 2 7.8 8.5 0.5 9.8 0.1 2.4 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Neur_chan_memb PF02932.11 CDI84334.1 - 2.5 7.8 7.0 19 5.0 4.6 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.2 CDI84334.1 - 8 3.9 8.4 9.3 3.7 5.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med15 PF09606.5 CDI84335.1 - 5.6 5.0 47.9 8.2 4.4 33.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Cwf_Cwc_15 PF04889.7 CDI84335.1 - 9.3 5.8 47.9 4.6 6.8 10.4 3.4 2 1 1 3 3 3 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.27 CDI84336.1 - 7.8e-26 88.9 2.5 1.3e-09 37.5 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat eIF2A PF08662.6 CDI84336.1 - 0.00017 21.3 0.0 6.8 6.3 0.0 3.4 3 0 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CDI84336.1 - 0.0007 17.8 0.0 0.19 9.8 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 LisH PF08513.6 CDI84336.1 - 0.056 13.2 0.0 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 LisH FACT-Spt16_Nlob PF14826.1 CDI84337.1 - 3.4e-17 62.4 0.1 5.5e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_S64 PF08192.6 CDI84337.1 - 0.029 12.7 4.9 0.032 12.5 3.4 1.2 1 0 0 1 1 1 0 Peptidase family S64 ATP-synt_ab_N PF02874.18 CDI84339.1 - 1.1e-18 67.1 0.6 2.3e-18 66.1 0.4 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 CDI84339.1 - 3.6e-08 33.1 0.1 5.3e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 HAS barrel domain DUF208 PF02677.9 CDI84339.1 - 0.00073 19.3 0.5 0.00093 19.0 0.3 1.1 1 0 0 1 1 1 1 Uncharacterized BCR, COG1636 PTS_EIIC_2 PF13303.1 CDI84339.1 - 0.17 10.7 7.6 0.26 10.0 5.3 1.3 1 0 0 1 1 1 0 Phosphotransferase system, EIIC Med3 PF11593.3 CDI84339.1 - 0.2 10.8 2.5 0.2 10.8 1.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ribosomal_60s PF00428.14 CDI84339.1 - 7.7 7.0 9.6 15 6.0 6.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Suf PF05843.9 CDI84347.1 - 0.0023 17.7 5.3 0.026 14.2 0.6 2.1 2 0 0 2 2 2 2 Suppressor of forked protein (Suf) DUF4207 PF13904.1 CDI84347.1 - 0.0026 17.1 26.9 0.0089 15.4 7.6 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4207) Zip PF02535.17 CDI84347.1 - 0.16 10.9 3.5 1.9 7.4 0.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Rsc14 PF08586.5 CDI84347.1 - 0.2 12.1 0.2 0.2 12.1 0.1 2.3 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit DUF912 PF06024.7 CDI84347.1 - 0.25 11.4 6.5 0.25 11.3 0.3 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Apc15p PF05841.6 CDI84347.1 - 0.29 11.8 27.4 0.11 13.2 4.6 2.7 2 1 1 3 3 3 0 Apc15p protein DUF2681 PF10883.3 CDI84347.1 - 4.6 7.4 12.2 14 5.9 8.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Pkinase PF00069.20 CDI84348.1 - 1.1e-67 227.9 0.0 1.1e-67 227.9 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84348.1 - 1.3e-28 99.8 0.0 1.3e-28 99.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Thioredoxin_8 PF13905.1 CDI84349.1 - 7.4e-48 160.6 0.0 8e-29 99.6 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CDI84349.1 - 5.9e-15 55.4 0.0 1.4e-09 38.1 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.16 CDI84349.1 - 2.7e-10 39.9 0.0 4.2e-08 32.9 0.0 3.0 3 0 0 3 3 3 1 AhpC/TSA family SCO1-SenC PF02630.9 CDI84349.1 - 1.3e-09 37.8 0.0 2.1e-06 27.4 0.0 3.1 3 0 0 3 3 3 1 SCO1/SenC Redoxin PF08534.5 CDI84349.1 - 5.5e-08 32.4 0.0 1.9e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Redoxin Thioredoxin PF00085.15 CDI84349.1 - 6.2e-08 32.2 0.0 5e-05 22.9 0.0 3.7 3 1 1 4 4 4 1 Thioredoxin Glutaredoxin PF00462.19 CDI84349.1 - 0.00038 20.3 0.3 0.38 10.7 0.1 3.7 2 1 0 2 2 2 1 Glutaredoxin Thioredoxin_6 PF13848.1 CDI84349.1 - 0.00064 19.5 1.3 9.7 5.9 0.0 3.9 4 0 0 4 4 4 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 CDI84349.1 - 0.0014 18.1 0.0 0.0047 16.5 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 CDI84349.1 - 0.027 14.4 0.1 0.7 9.9 0.0 3.0 3 0 0 3 3 3 0 Thioredoxin-like ABC_transp_aux PF09822.4 CDI84349.1 - 0.045 13.1 0.0 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 ABC-type uncharacterized transport system Response_reg PF00072.19 CDI84349.1 - 0.12 12.3 2.0 12 5.9 0.0 3.1 4 0 0 4 4 4 0 Response regulator receiver domain Ribosomal_60s PF00428.14 CDI84349.1 - 5.5 7.4 42.0 1.7 9.1 6.1 3.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein XRN_N PF03159.13 CDI84350.1 - 1.2e-13 51.0 14.1 6.1e-09 35.6 0.0 4.8 3 2 1 5 5 5 2 XRN 5'-3' exonuclease N-terminus Dicty_REP PF05086.7 CDI84350.1 - 0.65 7.6 6.3 1.5 6.4 4.4 1.5 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Silic_transp PF03842.8 CDI84350.1 - 0.87 7.5 0.1 1.7 6.6 0.1 1.3 1 0 0 1 1 1 0 Silicon transporter DHC_N1 PF08385.7 CDI84351.1 - 4.4e-149 497.5 0.5 4.4e-149 497.5 0.4 4.2 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 Dynein_heavy PF03028.10 CDI84351.1 - 2.3e-147 492.0 0.0 1.6e-146 489.2 0.0 2.2 1 1 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 CDI84351.1 - 1.8e-126 421.9 2.7 1.8e-126 421.9 1.9 3.4 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 CDI84351.1 - 1.2e-82 276.9 0.0 3.7e-82 275.3 0.0 1.9 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 CDI84351.1 - 8.1e-42 142.6 0.0 1.8e-41 141.4 0.0 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 CDI84351.1 - 8.7e-34 116.7 0.0 7.9e-32 110.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.9 CDI84351.1 - 9.4e-31 106.3 0.0 5.4e-11 42.3 0.0 6.3 4 2 0 4 4 4 4 AAA domain (dynein-related subfamily) MT PF12777.2 CDI84351.1 - 1.7e-20 73.0 16.1 7.9e-15 54.4 0.7 2.4 1 1 1 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 CDI84351.1 - 3.5e-15 55.8 0.1 8.4e-14 51.2 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region D3 AAA PF00004.24 CDI84351.1 - 7.5e-15 55.3 0.4 0.0048 17.1 0.0 6.1 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDI84351.1 - 9.8e-12 45.1 1.7 0.00073 19.6 0.0 7.3 6 1 0 6 6 6 1 AAA domain AAA_19 PF13245.1 CDI84351.1 - 8.6e-07 28.6 0.2 0.19 11.4 0.0 5.0 4 0 0 4 4 4 1 Part of AAA domain T2SE PF00437.15 CDI84351.1 - 4.3e-06 25.8 0.0 0.19 10.6 0.0 3.4 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_17 PF13207.1 CDI84351.1 - 2.1e-05 25.2 0.0 4 8.2 0.0 5.4 4 0 0 4 4 4 1 AAA domain Zeta_toxin PF06414.7 CDI84351.1 - 0.00011 21.4 0.1 0.088 11.8 0.0 4.1 4 0 0 4 4 4 1 Zeta toxin AAA_18 PF13238.1 CDI84351.1 - 0.00047 20.4 0.2 18 5.6 0.0 5.2 5 0 0 5 5 4 0 AAA domain AAA_14 PF13173.1 CDI84351.1 - 0.00061 19.6 0.0 2.7 7.8 0.0 4.4 5 0 0 5 5 2 1 AAA domain AAA_33 PF13671.1 CDI84351.1 - 0.0016 18.3 8.2 0.7 9.7 0.0 5.5 6 0 0 6 6 5 1 AAA domain IncA PF04156.9 CDI84351.1 - 0.0016 18.0 12.8 0.0016 18.0 8.9 5.3 6 0 0 6 6 5 1 IncA protein AAA_29 PF13555.1 CDI84351.1 - 0.0017 17.8 0.0 7.4 6.1 0.0 3.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_25 PF13481.1 CDI84351.1 - 0.0026 17.1 5.0 0.023 14.0 0.0 3.9 5 0 0 5 5 5 1 AAA domain Mg_chelatase PF01078.16 CDI84351.1 - 0.0046 16.1 3.8 5.3 6.1 0.0 4.4 3 1 1 4 4 4 1 Magnesium chelatase, subunit ChlI ResIII PF04851.10 CDI84351.1 - 0.0049 16.7 1.2 1.6 8.5 0.0 4.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 CDI84351.1 - 0.057 13.5 0.1 1e+02 3.1 0.0 4.6 4 0 0 4 4 4 0 RNA helicase Atg14 PF10186.4 CDI84351.1 - 1.2 8.0 21.3 0.51 9.2 4.0 3.5 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Ribosomal_L29 PF00831.18 CDI84352.1 - 5.1e-18 64.5 2.4 5.1e-18 64.5 1.7 1.9 2 1 0 2 2 2 1 Ribosomal L29 protein SYCE1 PF15233.1 CDI84352.1 - 0.14 12.0 7.5 0.39 10.6 5.2 1.6 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 5_3_exonuc_N PF02739.11 CDI84352.1 - 0.75 9.1 3.1 0.77 9.1 0.0 2.0 1 1 1 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain Uds1 PF15456.1 CDI84352.1 - 1.3 9.0 7.7 2 8.4 5.3 1.3 1 0 0 1 1 1 0 Up-regulated During Septation DUF4019 PF13211.1 CDI84352.1 - 7 6.9 7.1 3.5 7.9 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4019) TLD PF07534.11 CDI84353.1 - 6.6e-09 35.8 0.2 4.9e-05 23.3 0.1 3.1 2 1 1 3 3 3 2 TLD Glyco_trans_4_4 PF13579.1 CDI84353.1 - 0.0032 17.6 2.1 0.0045 17.1 0.3 2.0 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain SUI1 PF01253.17 CDI84354.1 - 1.4e-14 53.6 0.1 2.9e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 AJAP1_PANP_C PF15298.1 CDI84354.1 - 2.7 7.8 5.3 12 5.7 0.1 2.2 2 0 0 2 2 2 0 AJAP1/PANP C-terminus DUF4175 PF13779.1 CDI84358.1 - 0.0034 15.1 20.1 0.0045 14.7 13.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) PAT1 PF09770.4 CDI84358.1 - 0.0058 14.9 22.4 0.0067 14.7 15.5 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.7 CDI84358.1 - 0.024 14.5 4.3 0.032 14.1 3.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.9 CDI84358.1 - 0.047 13.4 11.9 0.071 12.8 8.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3721 PF12518.3 CDI84358.1 - 0.096 12.3 1.8 13 5.4 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function Spt20 PF12090.3 CDI84358.1 - 0.12 11.7 6.6 0.21 10.9 4.6 1.5 1 0 0 1 1 1 0 Spt20 family DUF2126 PF09899.4 CDI84358.1 - 0.12 10.4 6.8 0.16 9.9 4.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FimP PF09766.4 CDI84358.1 - 0.9 8.5 20.3 1.3 8.0 14.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein Baculo_PP31 PF05311.6 CDI84358.1 - 2.6 7.2 8.6 3.9 6.6 6.0 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Serinc PF03348.10 CDI84358.1 - 2.6 6.6 6.5 3.6 6.1 4.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.2 CDI84358.1 - 2.9 5.4 10.0 3.2 5.3 7.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Glyco_transf_15 PF01793.11 CDI84358.1 - 3.6 6.4 6.7 7 5.4 4.6 1.5 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase EIIBC-GUT_N PF03612.9 CDI84358.1 - 4.2 6.9 6.6 7.4 6.1 4.6 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus tRNA-synt_1 PF00133.17 CDI84359.1 - 1.8e-67 227.7 0.1 2.2e-67 227.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CDI84359.1 - 1.3e-34 119.2 0.1 3.2e-33 114.6 0.1 2.6 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA Val_tRNA-synt_C PF10458.4 CDI84359.1 - 2.7e-06 27.3 5.3 6e-06 26.2 3.7 1.6 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1g PF09334.6 CDI84359.1 - 5.3e-06 25.3 0.6 0.018 13.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1b PF00579.20 CDI84359.1 - 0.0035 16.5 0.1 0.0068 15.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.13 CDI84359.1 - 0.03 12.9 0.0 0.055 12.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Enkurin PF13864.1 CDI84359.1 - 0.24 11.6 3.5 1.9 8.7 2.4 2.5 1 1 0 1 1 1 0 Calmodulin-binding SpoIIE PF07228.7 CDI84361.1 - 0.0015 18.2 7.7 0.0044 16.7 0.0 3.6 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) FlxA PF14282.1 CDI84361.1 - 0.0038 17.1 19.1 0.0038 17.1 13.3 11.8 11 1 1 12 12 12 1 FlxA-like protein DUF2722 PF10846.3 CDI84362.1 - 0.00049 19.2 1.9 0.00053 19.1 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.8 CDI84362.1 - 0.0022 18.0 6.1 0.0022 18.0 4.2 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.4 CDI84362.1 - 0.16 11.4 8.6 0.2 11.1 6.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AUX_IAA PF02309.11 CDI84362.1 - 0.28 10.9 3.4 0.3 10.7 2.3 1.2 1 0 0 1 1 1 0 AUX/IAA family FDF PF09532.5 CDI84362.1 - 0.73 10.4 6.4 0.98 9.9 4.4 1.1 1 0 0 1 1 1 0 FDF domain DUF2457 PF10446.4 CDI84362.1 - 0.79 8.3 5.9 0.9 8.1 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3446 PF11928.3 CDI84362.1 - 0.88 9.8 8.9 1.3 9.2 6.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) Shisa PF13908.1 CDI84362.1 - 0.99 9.5 13.5 1.3 9.2 9.4 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SMN PF06003.7 CDI84362.1 - 1.3 8.0 4.1 1.4 7.9 2.9 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) RAB3GAP2_N PF14655.1 CDI84362.1 - 4.2 6.2 7.0 4.8 6.0 4.8 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4557 PF15101.1 CDI84362.1 - 7.8 6.2 10.4 9.4 6.0 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) CAF-1_p150 PF11600.3 CDI84363.1 - 2.8 7.2 53.3 3.9 6.7 37.0 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF4175 PF13779.1 CDI84365.1 - 0.11 10.1 27.7 0.15 9.7 19.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.8 CDI84365.1 - 0.14 12.0 16.9 0.17 11.7 11.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LETM1 PF07766.8 CDI84365.1 - 0.17 10.8 8.9 0.067 12.2 4.0 1.8 2 0 0 2 2 2 0 LETM1-like protein GvpL_GvpF PF06386.6 CDI84365.1 - 3 7.3 19.8 0.77 9.3 0.5 2.5 2 1 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Ribosomal_S8e PF01201.17 CDI84365.1 - 7.8 6.6 7.9 26 4.9 5.7 1.7 1 1 0 1 1 1 0 Ribosomal protein S8e CRF1 PF10380.4 CDI84365.1 - 8.2 6.7 7.2 15 5.9 3.0 2.1 2 0 0 2 2 2 0 Transcription factor CRF1 HEAT PF02985.17 CDI84366.1 - 0.39 10.9 9.7 3.2 8.0 0.3 5.0 4 0 0 4 4 4 0 HEAT repeat IF-2B PF01008.12 CDI84368.1 - 0.018 14.0 0.2 0.047 12.6 0.2 1.6 2 0 0 2 2 2 0 Initiation factor 2 subunit family RAP1 PF07218.6 CDI84368.1 - 9.4 4.1 3.7 14 3.6 2.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Mito_carr PF00153.22 CDI84369.1 - 4.3e-40 135.3 2.1 4.4e-18 64.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Glycos_transf_1 PF00534.15 CDI84371.1 - 2.5e-35 121.4 0.0 4.9e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CDI84371.1 - 4.9e-23 82.0 0.1 2e-21 76.8 0.0 2.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 CDI84371.1 - 3e-16 59.6 0.9 1e-15 57.8 0.6 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.6 CDI84371.1 - 3.5e-13 49.6 1.5 6.5e-11 42.1 0.2 2.8 2 1 0 2 2 2 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.1 CDI84371.1 - 4.3e-13 49.5 0.0 1.2e-12 48.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Alpha-amylase_C PF02806.13 CDI84371.1 - 3e-11 43.3 0.0 7e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 CDI84371.1 - 6.4e-09 35.6 0.0 4.7e-07 29.5 0.0 2.2 1 1 0 2 2 2 1 Alpha amylase, catalytic domain Glyco_trans_1_2 PF13524.1 CDI84371.1 - 0.0002 21.5 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.8 CDI84371.1 - 0.014 13.6 0.9 0.095 10.9 0.2 2.4 2 1 0 2 2 2 0 Glycogen synthase DUF1649 PF07855.7 CDI84372.1 - 0.0061 16.2 0.0 0.066 12.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1649) TTL PF03133.10 CDI84372.1 - 0.013 14.4 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 Tubulin-tyrosine ligase family zf-CCCH_2 PF14608.1 CDI84373.1 - 1e-07 31.6 31.9 0.0023 17.8 4.6 3.3 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type zf-CCCH PF00642.19 CDI84373.1 - 0.015 14.9 21.9 0.017 14.8 0.3 4.0 3 1 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHH PF10283.4 CDI84373.1 - 0.22 11.3 16.4 2.3 8.1 0.6 3.6 3 0 0 3 3 3 0 Zinc-finger (CX5CX6HX5H) motif Gpi1 PF05024.10 CDI84374.1 - 2.8e-31 108.6 15.5 4.2e-23 82.0 4.0 2.9 3 0 0 3 3 3 2 N-acetylglucosaminyl transferase component (Gpi1) TSSC4 PF15264.1 CDI84375.1 - 0.0072 16.7 0.2 0.019 15.4 0.2 1.8 1 1 0 1 1 1 1 Tumour suppressing sub-chromosomal transferable candidate 4 Herpes_UL32 PF06070.6 CDI84375.1 - 1.3 7.4 10.3 1.5 7.1 7.2 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 CDK2AP PF09806.4 CDI84376.1 - 0.041 14.1 0.3 0.041 14.1 0.2 3.1 3 1 1 4 4 4 0 Cyclin-dependent kinase 2-associated protein DUF3953 PF13129.1 CDI84376.1 - 1.3 8.6 3.7 53 3.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3953) ABC1 PF03109.11 CDI84377.1 - 1.3e-31 109.0 0.2 3.4e-31 107.6 0.2 1.7 1 0 0 1 1 1 1 ABC1 family DEAD PF00270.24 CDI84377.1 - 8.3e-11 41.6 0.0 2.6e-08 33.5 0.0 2.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase RIO1 PF01163.17 CDI84377.1 - 0.12 11.7 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Ribonuc_P_40 PF08584.6 CDI84379.1 - 0.11 11.5 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit AAA_23 PF13476.1 CDI84380.1 - 9.6e-05 22.7 0.0 0.00012 22.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDI84380.1 - 0.0025 17.2 0.3 0.0088 15.5 0.1 2.1 2 1 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.14 CDI84380.1 - 0.085 12.0 0.0 0.2 10.8 0.0 1.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Metallophos_2 PF12850.2 CDI84381.1 - 0.00024 20.9 0.0 0.0036 17.1 0.0 2.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 CDI84381.1 - 0.033 13.5 0.5 0.12 11.7 0.3 2.0 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase TPR_11 PF13414.1 CDI84382.1 - 1.8e-16 59.4 0.4 1.5e-08 34.1 0.2 3.8 2 1 2 4 4 4 3 TPR repeat TPR_1 PF00515.23 CDI84382.1 - 2.7e-13 48.8 6.1 9.6e-05 21.8 0.3 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI84382.1 - 2.9e-12 45.5 5.4 0.0065 16.2 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDI84382.1 - 1.8e-10 39.8 0.1 0.078 12.8 0.0 4.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 CDI84382.1 - 7.9e-09 35.3 1.2 0.17 12.6 0.0 4.7 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 CDI84382.1 - 8.8e-09 34.5 0.4 0.12 12.2 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDI84382.1 - 1.7e-08 34.6 0.2 0.03 14.6 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 CDI84382.1 - 3.5e-07 30.7 4.8 0.012 16.2 0.0 4.2 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 CDI84382.1 - 4.5e-07 29.9 0.2 0.54 10.8 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDI84382.1 - 5.7e-07 29.3 2.7 0.21 11.5 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDI84382.1 - 4.6e-06 26.3 3.8 0.0032 17.2 0.7 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.1 CDI84382.1 - 8.5e-06 25.0 0.0 1.6e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDI84382.1 - 5.7e-05 23.0 0.0 9.9 6.6 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat Apc3 PF12895.2 CDI84382.1 - 0.00084 19.4 2.1 0.027 14.5 0.3 2.9 3 0 0 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.4 CDI84382.1 - 0.035 13.4 0.1 0.73 9.1 0.1 2.2 2 0 0 2 2 2 0 26S proteasome subunit RPN7 DUF244 PF03112.9 CDI84383.1 - 1.6 8.2 0.5 2.5 7.6 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF Period_C PF12114.3 CDI84384.1 - 5.9 6.4 10.1 9.4 5.7 7.0 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region TrmE_N PF10396.4 CDI84385.1 - 2.7e-20 72.4 0.0 1.5e-09 37.8 0.0 3.9 3 0 0 3 3 3 3 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 CDI84385.1 - 2.8e-15 56.2 0.0 8e-15 54.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Med15 PF09606.5 CDI84385.1 - 3e-05 22.4 32.8 3e-05 22.4 22.7 3.5 3 1 0 3 3 3 2 ARC105 or Med15 subunit of Mediator complex non-fungal Dynamin_N PF00350.18 CDI84385.1 - 0.0021 17.9 0.0 0.0021 17.9 0.0 4.3 4 2 0 4 4 4 1 Dynamin family Secretin_N_2 PF07655.8 CDI84385.1 - 0.012 16.0 5.6 0.012 16.0 3.9 4.9 4 1 0 4 4 4 0 Secretin N-terminal domain FeoB_N PF02421.13 CDI84385.1 - 0.039 13.2 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Miro PF08477.8 CDI84385.1 - 0.46 10.9 0.0 0.46 10.9 0.0 2.7 4 0 0 4 4 4 0 Miro-like protein DUF4220 PF13968.1 CDI84385.1 - 2.9 6.8 18.6 0.79 8.7 2.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4220) Pkinase PF00069.20 CDI84386.1 - 8.6e-08 31.6 1.4 8.6e-08 31.6 1.0 3.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84386.1 - 5e-05 22.5 2.0 0.00047 19.3 0.0 2.9 3 0 0 3 3 3 1 Protein tyrosine kinase S10_plectin PF03501.10 CDI84387.1 - 2.4e-39 133.0 0.2 2.9e-39 132.8 0.2 1.0 1 0 0 1 1 1 1 Plectin/S10 domain zf-B_box PF00643.19 CDI84390.1 - 1.2e-05 25.1 4.3 1.2e-05 25.1 3.0 3.7 4 1 0 4 4 4 1 B-box zinc finger zf-C3HC4_2 PF13923.1 CDI84390.1 - 9.5 6.3 30.3 9 6.4 9.8 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 CDI84392.1 - 3.9e-06 26.2 0.0 1.1e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 CDI84392.1 - 9.4e-06 24.7 0.0 1.6e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF1510 PF07423.6 CDI84403.1 - 0.0023 17.3 24.6 0.0024 17.2 17.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) CAF-1_p150 PF11600.3 CDI84403.1 - 0.012 14.9 29.1 0.014 14.7 20.2 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CDC45 PF02724.9 CDI84403.1 - 0.036 12.1 25.0 0.037 12.0 17.4 1.1 1 0 0 1 1 1 0 CDC45-like protein OmpH PF03938.9 CDI84403.1 - 0.037 13.9 40.3 0.061 13.2 27.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BTV_NS2 PF04514.7 CDI84403.1 - 0.068 12.0 21.7 0.074 11.9 15.0 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Nha1_C PF08619.5 CDI84403.1 - 0.091 12.0 23.3 0.1 11.8 16.1 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Neur_chan_memb PF02932.11 CDI84403.1 - 0.11 12.4 11.1 0.12 12.1 7.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Trypan_PARP PF05887.6 CDI84403.1 - 0.15 11.9 6.4 0.24 11.2 4.4 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ycf1 PF05758.7 CDI84403.1 - 0.21 9.2 20.7 0.24 9.0 14.3 1.1 1 0 0 1 1 1 0 Ycf1 Presenilin PF01080.12 CDI84403.1 - 0.28 9.9 13.4 0.35 9.6 9.3 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.1 CDI84403.1 - 0.41 10.3 15.5 0.5 10.0 10.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CENP-T PF15511.1 CDI84403.1 - 0.68 9.1 28.5 0.8 8.8 19.8 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Pox_Ag35 PF03286.9 CDI84403.1 - 0.69 9.3 16.5 0.98 8.9 11.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Spore_coat_CotO PF14153.1 CDI84403.1 - 1.3 8.4 37.2 1.8 7.9 25.8 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Zip PF02535.17 CDI84403.1 - 1.5 7.7 12.9 3.3 6.6 8.9 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter Pilt PF15453.1 CDI84403.1 - 1.6 8.3 22.1 1.9 8.1 15.3 1.1 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions FLO_LFY PF01698.11 CDI84403.1 - 1.8 7.2 21.5 2.1 7.0 14.9 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein RR_TM4-6 PF06459.7 CDI84403.1 - 1.9 8.3 25.8 2.3 8.0 17.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPP4R2 PF09184.6 CDI84403.1 - 1.9 7.9 27.3 2.3 7.7 18.9 1.0 1 0 0 1 1 1 0 PPP4R2 DHHW PF14286.1 CDI84403.1 - 2 7.6 19.7 2.3 7.4 13.6 1.2 1 0 0 1 1 1 0 DHHW protein Herpes_UL87 PF03043.9 CDI84403.1 - 2.3 6.5 10.1 2.5 6.4 7.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL87 family AUX_IAA PF02309.11 CDI84403.1 - 2.3 7.8 17.6 3.2 7.4 12.2 1.3 1 0 0 1 1 1 0 AUX/IAA family GAGA_bind PF06217.7 CDI84403.1 - 3.2 7.6 22.5 3.7 7.4 15.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4045 PF13254.1 CDI84403.1 - 4 6.6 21.5 4.4 6.4 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Raftlin PF15250.1 CDI84403.1 - 5.1 5.5 23.4 6.1 5.2 16.2 1.1 1 0 0 1 1 1 0 Raftlin Dapper PF15268.1 CDI84403.1 - 5.1 5.7 27.0 5.4 5.6 18.7 1.0 1 0 0 1 1 1 0 Dapper Hid1 PF12722.2 CDI84403.1 - 5.2 4.6 25.0 5.7 4.4 17.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF-3_zeta PF05091.7 CDI84403.1 - 5.6 5.4 27.1 6.4 5.2 18.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Daxx PF03344.10 CDI84403.1 - 5.7 5.2 30.5 6.7 5.0 21.2 1.1 1 0 0 1 1 1 0 Daxx Family Membralin PF09746.4 CDI84403.1 - 6.8 5.6 8.7 8.5 5.3 6.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein Caldesmon PF02029.10 CDI84403.1 - 8.6 4.6 31.6 9.7 4.4 21.9 1.0 1 0 0 1 1 1 0 Caldesmon SAGA-Tad1 PF12767.2 CDI84403.1 - 8.6 5.9 25.6 12 5.5 17.7 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PA26 PF04636.8 CDI84403.1 - 8.7 4.9 17.8 9.8 4.7 12.3 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Vfa1 PF08432.5 CDI84403.1 - 9 6.2 27.6 12 5.8 19.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1675 PF07897.6 CDI84403.1 - 9.7 5.9 16.1 11 5.7 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) SNF2_N PF00176.18 CDI84404.1 - 9.4e-63 211.7 0.2 9.4e-63 211.7 0.2 4.1 2 1 1 3 3 3 1 SNF2 family N-terminal domain Chromo PF00385.19 CDI84404.1 - 7.5e-13 47.9 2.6 1.5e-07 31.0 0.2 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ATP-synt_ab PF00006.20 CDI84408.1 - 5.2e-63 212.4 0.0 8.5e-63 211.7 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.18 CDI84408.1 - 1.8e-22 79.2 0.7 3.6e-22 78.3 0.5 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab_C PF00306.22 CDI84408.1 - 4.5e-21 75.4 0.2 4.5e-21 75.4 0.2 1.6 2 0 0 2 2 1 1 ATP synthase alpha/beta chain, C terminal domain MobB PF03205.9 CDI84408.1 - 0.0017 18.0 0.1 4.5 6.9 0.0 3.3 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B RnfC_N PF13375.1 CDI84408.1 - 0.0073 16.0 0.4 0.018 14.7 0.3 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain AAA PF00004.24 CDI84408.1 - 0.0092 16.1 2.3 0.32 11.1 0.0 3.5 3 2 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 CDI84408.1 - 0.012 14.7 0.6 0.026 13.6 0.4 1.5 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.1 CDI84408.1 - 0.013 15.5 1.0 0.17 11.8 0.0 2.7 2 1 1 3 3 3 0 AAA ATPase domain NB-ARC PF00931.17 CDI84408.1 - 0.015 14.1 0.1 0.029 13.2 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain Arch_ATPase PF01637.13 CDI84408.1 - 0.037 13.7 0.0 0.087 12.5 0.0 1.6 2 0 0 2 2 2 0 Archaeal ATPase AAA_22 PF13401.1 CDI84408.1 - 0.039 14.0 0.1 0.53 10.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF258 PF03193.11 CDI84408.1 - 0.068 12.3 0.1 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 CDI84408.1 - 0.079 12.6 1.3 0.37 10.4 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.1 CDI84408.1 - 0.11 11.8 4.4 0.16 11.3 0.2 2.7 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 CDI84408.1 - 0.18 12.0 0.0 0.42 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 CDI84408.1 - 0.34 11.2 2.1 0.4 10.9 0.1 2.0 2 0 0 2 2 2 0 ABC transporter Glyco_hydro_63 PF03200.11 CDI84409.1 - 0.15 9.8 16.5 0.17 9.6 11.4 1.0 1 0 0 1 1 1 0 Mannosyl oligosaccharide glucosidase FAM60A PF15396.1 CDI84409.1 - 1 9.0 8.7 1.3 8.6 6.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Bud13 PF09736.4 CDI84409.1 - 1.3 9.3 21.6 1.5 9.0 15.0 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Ebp2 PF05890.7 CDI84411.1 - 1.3e-29 103.3 0.9 2.1e-29 102.6 0.6 1.2 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 SR-25 PF10500.4 CDI84412.1 - 0.16 11.4 29.7 0.2 11.0 20.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FLO_LFY PF01698.11 CDI84412.1 - 1.5 7.6 33.8 1.8 7.3 23.4 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Raftlin PF15250.1 CDI84412.1 - 8.6 4.7 29.9 12 4.2 20.7 1.3 1 0 0 1 1 1 0 Raftlin Nha1_C PF08619.5 CDI84412.1 - 8.7 5.4 37.0 11 5.1 25.6 1.0 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus MAT1 PF06391.8 CDI84413.1 - 0.17 11.4 6.0 0.18 11.3 4.2 1.0 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF3847 PF12958.2 CDI84413.1 - 0.3 10.8 6.4 0.37 10.5 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) OmpH PF03938.9 CDI84413.1 - 0.35 10.7 18.2 0.43 10.5 12.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APP_Cu_bd PF12924.2 CDI84413.1 - 0.42 11.1 2.9 1.7 9.2 0.2 2.1 2 0 0 2 2 2 0 Copper-binding of amyloid precursor, CuBD SGT1 PF07093.6 CDI84413.1 - 0.53 8.6 4.2 0.58 8.4 2.9 1.0 1 0 0 1 1 1 0 SGT1 protein CDK5_activator PF03261.10 CDI84413.1 - 0.72 9.1 8.6 0.74 9.0 6.0 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein BAF1_ABF1 PF04684.8 CDI84413.1 - 0.84 8.4 20.0 1 8.1 13.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CDK2AP PF09806.4 CDI84413.1 - 2.7 8.2 10.7 3 8.0 7.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Ufd2P_core PF10408.4 CDI84413.1 - 4.9 5.2 6.1 5 5.2 4.2 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core FCP1_C PF09309.5 CDI84413.1 - 8.6 5.5 12.3 9.3 5.4 8.4 1.2 1 1 0 1 1 1 0 FCP1, C-terminal Med15 PF09606.5 CDI84413.1 - 9.9 4.2 30.2 10 4.1 20.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CAF-1_p150 PF11600.3 CDI84414.1 - 0.019 14.3 33.0 0.032 13.5 22.9 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal HlyD_2 PF12700.2 CDI84414.1 - 0.026 13.6 13.8 0.03 13.4 9.5 1.1 1 0 0 1 1 1 0 HlyD family secretion protein SOBP PF15279.1 CDI84414.1 - 0.042 14.2 23.6 0.055 13.8 16.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SprA-related PF12118.3 CDI84414.1 - 0.23 10.7 55.9 0.31 10.3 38.8 1.1 1 0 0 1 1 1 0 SprA-related family PAT1 PF09770.4 CDI84414.1 - 0.37 8.9 56.2 0.45 8.7 39.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AAA_23 PF13476.1 CDI84414.1 - 0.51 10.6 20.9 0.68 10.2 14.5 1.3 1 0 0 1 1 1 0 AAA domain LMBR1 PF04791.11 CDI84414.1 - 0.87 8.0 3.8 0.84 8.1 2.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Med15 PF09606.5 CDI84414.1 - 1.4 7.0 71.5 1.7 6.7 49.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal HemX PF04375.9 CDI84414.1 - 2.4 6.6 33.8 2.9 6.3 23.5 1.2 1 0 0 1 1 1 0 HemX Ycf1 PF05758.7 CDI84414.1 - 4.9 4.7 20.2 6 4.4 14.0 1.1 1 0 0 1 1 1 0 Ycf1 N6_N4_Mtase PF01555.13 CDI84414.1 - 6.4 6.1 8.2 8.6 5.7 5.7 1.2 1 0 0 1 1 1 0 DNA methylase eIF-3_zeta PF05091.7 CDI84414.1 - 7.5 5.0 29.5 8.7 4.8 20.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PCEMA1 PF07418.6 CDI84414.1 - 9.2 5.5 11.3 12 5.1 7.9 1.2 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 PAT1 PF09770.4 CDI84415.1 - 5.1 5.2 15.2 5.2 5.1 10.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.9 CDI84415.1 - 8.4 6.0 6.8 10 5.7 4.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ras PF00071.17 CDI84421.1 - 5.1e-25 87.7 0.4 9.7e-25 86.8 0.3 1.4 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDI84421.1 - 2.4e-07 31.2 0.3 4.5e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 CDI84421.1 - 0.011 15.2 0.1 0.018 14.4 0.1 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Arf PF00025.16 CDI84421.1 - 0.013 14.7 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF1777 PF08648.7 CDI84421.1 - 0.031 14.0 10.2 0.05 13.3 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) FeoB_N PF02421.13 CDI84421.1 - 0.048 12.9 0.0 0.064 12.5 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF2217 PF10265.4 CDI84421.1 - 0.071 11.8 15.1 0.082 11.6 10.5 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 CDI84421.1 - 0.09 11.0 25.3 0.11 10.7 17.5 1.1 1 0 0 1 1 1 0 Transmembrane protein NPR3 PF03666.8 CDI84421.1 - 0.16 10.5 13.4 0.24 9.8 9.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Golgin_A5 PF09787.4 CDI84421.1 - 0.51 8.7 17.4 0.59 8.5 12.1 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DHHW PF14286.1 CDI84421.1 - 0.68 9.1 6.8 0.9 8.7 4.7 1.1 1 0 0 1 1 1 0 DHHW protein Apt1 PF10351.4 CDI84421.1 - 0.99 8.1 18.4 1.4 7.6 12.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Miff PF05644.6 CDI84421.1 - 1.7 8.1 9.2 2.5 7.6 6.4 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff DNA_pol_viral_N PF00242.12 CDI84421.1 - 1.8 7.5 24.7 2.5 7.0 17.1 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Peptidase_S64 PF08192.6 CDI84421.1 - 2.9 6.1 18.0 3.4 5.9 12.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4551 PF15087.1 CDI84421.1 - 7.2 4.8 16.6 9.3 4.4 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Tmemb_cc2 PF10267.4 CDI84421.1 - 7.7 4.9 17.1 10 4.5 11.9 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Mating_C PF12737.2 CDI84423.1 - 0.8 8.5 26.8 0.92 8.3 18.5 1.0 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 Apt1 PF10351.4 CDI84423.1 - 1.4 7.6 17.4 1.7 7.4 12.1 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.4 CDI84423.1 - 1.6 6.8 17.1 2.4 6.3 11.8 1.3 1 0 0 1 1 1 0 Transmembrane protein Rtf2 PF04641.7 CDI84423.1 - 1.9 7.6 15.4 2.3 7.3 10.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger G-alpha PF00503.15 CDI84423.1 - 3.1 6.3 13.8 4.3 5.9 9.6 1.2 1 0 0 1 1 1 0 G-protein alpha subunit DUF2052 PF09747.4 CDI84423.1 - 3.7 7.4 16.7 4.8 7.0 11.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MCPVI PF02993.9 CDI84423.1 - 4 7.5 16.7 4.7 7.2 11.6 1.1 1 0 0 1 1 1 0 Minor capsid protein VI E7 PF00527.13 CDI84423.1 - 5 7.3 14.7 1.4 9.1 3.9 2.1 2 0 0 2 2 2 0 E7 protein, Early protein Big_2 PF02368.13 CDI84423.1 - 6.3 6.7 12.9 0.93 9.4 3.5 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 2) U1snRNP70_N PF12220.3 CDI84423.1 - 6.3 7.1 18.3 9 6.7 0.8 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SR-25 PF10500.4 CDI84423.1 - 6.8 6.0 32.8 3.7 6.9 13.0 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Totivirus_coat PF05518.6 CDI84423.1 - 7.6 4.2 13.0 9 3.9 9.0 1.0 1 0 0 1 1 1 0 Totivirus coat protein ATP-synt_E PF05680.7 CDI84423.1 - 8.9 6.3 15.3 0.22 11.5 2.3 2.1 2 0 0 2 2 2 0 ATP synthase E chain SpoIIIAH PF12685.2 CDI84423.1 - 9.9 5.6 19.2 11 5.4 13.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein ATP-synt_F PF01990.12 CDI84424.1 - 3.9e-14 52.8 0.1 3.9e-14 52.8 0.1 2.2 2 1 1 3 3 3 1 ATP synthase (F/14-kDa) subunit Ycf1 PF05758.7 CDI84424.1 - 0.017 12.8 5.1 0.015 13.0 3.5 1.1 1 0 0 1 1 1 0 Ycf1 DUF2076 PF09849.4 CDI84424.1 - 0.089 12.8 25.1 0.12 12.3 17.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Cellulose_synt PF03552.9 CDI84424.1 - 0.091 11.0 2.2 0.1 10.8 1.5 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF2413 PF10310.4 CDI84424.1 - 0.21 10.3 24.0 0.34 9.6 16.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) LMBR1 PF04791.11 CDI84424.1 - 0.22 10.0 2.7 0.25 9.8 1.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein BTV_NS2 PF04514.7 CDI84424.1 - 0.67 8.7 17.7 0.9 8.3 12.3 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CDK5_activator PF03261.10 CDI84424.1 - 1.2 8.4 12.3 1.5 8.0 8.6 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF844 PF05815.6 CDI84424.1 - 1.2 7.9 10.9 1.6 7.5 7.5 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) Med15 PF09606.5 CDI84424.1 - 1.6 6.8 45.1 2 6.5 31.3 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Zip PF02535.17 CDI84424.1 - 1.6 7.6 4.7 2.1 7.2 3.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4175 PF13779.1 CDI84424.1 - 1.8 6.1 34.9 2.4 5.7 24.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Pal1 PF08316.6 CDI84424.1 - 2.5 8.5 7.2 4.3 7.7 5.0 1.5 1 0 0 1 1 1 0 Pal1 cell morphology protein AUX_IAA PF02309.11 CDI84424.1 - 3 7.5 14.1 4.2 7.0 9.7 1.3 1 0 0 1 1 1 0 AUX/IAA family Band_3_cyto PF07565.8 CDI84424.1 - 5.1 6.5 15.0 7.3 6.0 10.4 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SAGA-Tad1 PF12767.2 CDI84424.1 - 5.6 6.5 20.8 7.9 6.0 14.4 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Presenilin PF01080.12 CDI84424.1 - 5.9 5.5 7.1 7.5 5.2 4.9 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.2 CDI84424.1 - 6.1 4.3 16.0 6.6 4.2 11.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4658 PF15555.1 CDI84424.1 - 7.1 6.5 8.1 10 6.0 4.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4658) UPF0560 PF10577.4 CDI84424.1 - 8.9 4.4 15.3 11 4.1 10.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ribosomal_60s PF00428.14 CDI84424.1 - 9.5 6.7 11.8 1.3 9.5 5.2 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Neur_chan_memb PF02932.11 CDI84424.1 - 9.6 6.0 10.8 14 5.5 7.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region COX6B PF02297.12 CDI84428.1 - 0.00011 22.1 5.0 0.00023 21.0 3.5 1.5 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb RCC1 PF00415.13 CDI84430.1 - 4.1e-29 100.5 9.1 5e-08 33.0 0.1 7.6 6 2 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDI84430.1 - 2.7e-13 49.1 33.0 0.00063 19.2 1.4 5.8 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat zf-RanBP PF00641.13 CDI84430.1 - 0.18 10.9 12.8 0.025 13.7 5.9 1.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Bunya_G1 PF03557.10 CDI84431.1 - 5.2 4.7 8.6 5.9 4.5 5.9 1.0 1 0 0 1 1 1 0 Bunyavirus glycoprotein G1 Cyt_c_ox_IV PF12270.3 CDI84432.1 - 0.39 10.4 1.4 1.1 9.0 1.0 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Ribosomal_L5_C PF00673.16 CDI84434.1 - 3.5e-24 84.3 0.0 5e-24 83.8 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 CDI84434.1 - 1.3e-19 69.7 0.3 6.6e-19 67.4 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L5 V-SNARE_C PF12352.3 CDI84434.1 - 0.084 12.9 0.3 0.32 11.0 0.0 1.9 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus ADH_zinc_N PF00107.21 CDI84435.1 - 3.8e-24 84.7 0.1 5.2e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDI84435.1 - 4.6e-11 42.4 8.4 1.6e-10 40.6 5.8 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain UDPG_MGDP_dh_N PF03721.9 CDI84435.1 - 0.0017 17.7 0.2 0.0026 17.1 0.1 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ELFV_dehydrog PF00208.16 CDI84435.1 - 0.076 12.5 0.4 0.12 11.8 0.3 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.14 CDI84435.1 - 0.18 10.9 0.5 0.57 9.3 0.1 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 CDI84435.1 - 1.1 9.0 3.7 7.5 6.3 1.6 2.2 1 1 1 2 2 2 0 ThiF family DUF605 PF04652.11 CDI84437.1 - 5.3 6.3 28.9 11 5.3 20.0 1.5 1 0 0 1 1 1 0 Vta1 like Pkinase PF00069.20 CDI84439.1 - 8.9e-47 159.4 0.6 5e-41 140.5 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84439.1 - 3.4e-25 88.5 0.1 5.1e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CDI84439.1 - 3.9e-06 26.0 0.1 6e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CDI84439.1 - 0.00016 20.7 0.0 0.0077 15.2 0.0 2.2 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 CDI84439.1 - 0.00092 19.0 0.0 0.47 10.1 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Cytokin-bind PF09265.5 CDI84439.1 - 0.043 12.9 0.0 0.094 11.8 0.0 1.6 1 1 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding YrbL-PhoP_reg PF10707.4 CDI84439.1 - 0.047 13.0 0.0 0.1 11.9 0.0 1.5 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL RRM_1 PF00076.17 CDI84440.1 - 8.1e-18 63.8 0.1 1.1e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDI84440.1 - 2.8e-13 49.6 0.0 4.1e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI84440.1 - 1.7e-06 27.7 0.0 2.6e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDI84440.1 - 0.016 14.9 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF1864 PF08933.6 CDI84442.1 - 0.069 11.6 0.0 0.15 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1864) Porin_3 PF01459.17 CDI84444.1 - 5.2e-21 75.1 0.0 1.2e-20 73.9 0.0 1.5 1 1 1 2 2 2 1 Eukaryotic porin DUF3645 PF12359.3 CDI84444.1 - 0.07 12.2 0.8 0.32 10.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3645) NIF PF03031.13 CDI84445.1 - 1.1e-14 54.3 0.0 2.2e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 CDI84445.1 - 0.0088 16.2 0.0 0.16 12.1 0.0 2.2 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase U1snRNP70_N PF12220.3 CDI84445.1 - 0.096 13.0 8.0 0.23 11.7 5.6 1.7 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PP2C PF00481.16 CDI84448.1 - 0.027 13.8 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C APG6 PF04111.7 CDI84449.1 - 2.2 7.2 35.2 3.4 6.6 24.4 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Activator_LAG-3 PF11498.3 CDI84449.1 - 2.2 6.9 78.2 12 4.4 51.9 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Fasciclin PF02469.17 CDI84451.1 - 2.4e-10 40.5 8.7 2.2e-06 27.6 1.3 3.2 2 1 0 2 2 2 2 Fasciclin domain Zip PF02535.17 CDI84451.1 - 0.00084 18.4 1.9 0.0011 17.9 1.3 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter RR_TM4-6 PF06459.7 CDI84451.1 - 0.0025 17.7 3.7 0.0037 17.1 2.6 1.3 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 YqfQ PF14181.1 CDI84451.1 - 0.0073 16.3 8.2 0.0073 16.3 5.7 2.5 2 1 0 2 2 2 1 YqfQ-like protein Pex14_N PF04695.8 CDI84451.1 - 0.0076 16.3 13.5 0.0076 16.3 9.3 2.0 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AIF_C PF14721.1 CDI84451.1 - 0.0084 16.3 4.0 0.015 15.5 2.8 1.4 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Nha1_C PF08619.5 CDI84451.1 - 0.012 14.8 9.6 0.018 14.3 6.7 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF1764 PF08576.5 CDI84451.1 - 0.037 14.8 9.4 0.071 13.8 6.5 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF2126 PF09899.4 CDI84451.1 - 0.066 11.2 6.4 0.096 10.7 4.4 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Spore_YhcN_YlaJ PF09580.5 CDI84451.1 - 0.09 12.8 6.3 0.13 12.3 4.4 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Anoctamin PF04547.7 CDI84451.1 - 0.11 11.1 0.4 0.11 11.1 0.3 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel RNA_pol_Rpc4 PF05132.9 CDI84451.1 - 0.11 12.4 8.6 0.2 11.6 5.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF73-100_C PF11718.3 CDI84451.1 - 0.12 11.7 8.0 0.25 10.6 5.5 1.4 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term DUF2146 PF10220.4 CDI84451.1 - 0.27 9.1 10.0 0.39 8.6 6.9 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Dehalogenase PF13486.1 CDI84451.1 - 0.33 10.3 5.8 0.53 9.6 4.1 1.2 1 0 0 1 1 1 0 Reductive dehalogenase subunit ATG22 PF11700.3 CDI84451.1 - 0.33 9.3 2.0 1.8 6.9 0.7 2.2 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Presenilin PF01080.12 CDI84451.1 - 0.37 9.5 3.7 0.52 9.0 2.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.9 CDI84451.1 - 0.43 8.5 10.3 0.62 8.0 7.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Folate_carrier PF01770.13 CDI84451.1 - 0.6 8.5 7.9 0.95 7.9 5.5 1.2 1 0 0 1 1 1 0 Reduced folate carrier CPSF100_C PF13299.1 CDI84451.1 - 0.88 9.7 9.4 1.7 8.7 6.5 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FLO_LFY PF01698.11 CDI84451.1 - 0.94 8.2 11.2 1.4 7.6 7.7 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Sec62 PF03839.11 CDI84451.1 - 0.96 8.8 4.6 1.4 8.2 3.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 AUX_IAA PF02309.11 CDI84451.1 - 1.1 9.0 8.7 1.7 8.3 6.0 1.3 1 0 0 1 1 1 0 AUX/IAA family FimP PF09766.4 CDI84451.1 - 1.2 8.1 22.6 2.5 7.0 15.7 1.5 1 0 0 1 1 1 0 Fms-interacting protein YkuI_C PF10388.4 CDI84451.1 - 1.3 8.7 13.2 2.3 7.8 9.2 1.3 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain PBP1_TM PF14812.1 CDI84451.1 - 1.4 9.3 4.8 2.3 8.5 3.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FNIP_N PF14636.1 CDI84451.1 - 1.6 9.2 16.5 3 8.3 11.4 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus Ycf1 PF05758.7 CDI84451.1 - 1.8 6.1 11.5 2.4 5.7 8.0 1.1 1 0 0 1 1 1 0 Ycf1 Peptidase_S49_N PF08496.5 CDI84451.1 - 1.8 8.3 11.5 3.3 7.4 8.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HD-ZIP_N PF04618.7 CDI84451.1 - 2.4 8.7 6.6 4.8 7.7 4.6 1.6 1 0 0 1 1 1 0 HD-ZIP protein N terminus HemX PF04375.9 CDI84451.1 - 2.8 6.4 32.1 0.076 11.6 16.6 2.0 2 0 0 2 2 2 0 HemX DUF605 PF04652.11 CDI84451.1 - 2.9 7.1 21.6 5.2 6.3 15.0 1.3 1 0 0 1 1 1 0 Vta1 like DUF3043 PF11241.3 CDI84451.1 - 3.3 7.2 7.5 7.1 6.1 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Peptidase_U57 PF05582.7 CDI84451.1 - 3.5 6.4 10.2 5.9 5.7 7.0 1.2 1 0 0 1 1 1 0 YabG peptidase U57 FemAB PF02388.11 CDI84451.1 - 3.6 6.1 14.3 0.84 8.2 7.7 1.5 2 0 0 2 2 2 0 FemAB family FAM176 PF14851.1 CDI84451.1 - 3.9 7.1 6.1 3.5 7.2 3.2 1.7 2 0 0 2 2 1 0 FAM176 family DDHD PF02862.12 CDI84451.1 - 4.1 7.1 11.9 6.6 6.4 8.3 1.2 1 0 0 1 1 1 0 DDHD domain Baculo_PP31 PF05311.6 CDI84451.1 - 4.5 6.4 12.6 6.5 5.9 8.8 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) FAM60A PF15396.1 CDI84451.1 - 5.2 6.7 10.6 8.2 6.1 7.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SelP_N PF04592.9 CDI84451.1 - 5.3 6.3 22.4 10 5.4 15.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TFIIA PF03153.8 CDI84451.1 - 7.6 6.3 32.1 1.2 8.9 17.7 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Glyco_transf_15 PF01793.11 CDI84451.1 - 7.7 5.3 13.8 11 4.8 9.6 1.2 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase CRF1 PF10380.4 CDI84451.1 - 7.9 6.8 8.0 17 5.7 5.5 1.5 1 0 0 1 1 1 0 Transcription factor CRF1 Spore_coat_CotO PF14153.1 CDI84451.1 - 8.2 5.8 23.2 15 4.9 16.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DUF1631 PF07793.6 CDI84451.1 - 8.6 4.3 31.7 0.27 9.3 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1631) SUFU_C PF12470.3 CDI84452.1 - 0.11 12.1 6.6 0.18 11.4 4.6 1.3 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain DLIC PF05783.6 CDI84452.1 - 0.83 8.2 13.0 1.1 7.8 9.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Plasmodium_Vir PF05795.6 CDI84452.1 - 1.8 7.6 4.6 2.1 7.4 3.2 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SoxE PF06525.6 CDI84452.1 - 4.8 6.4 11.0 7.2 5.8 7.6 1.3 1 0 0 1 1 1 0 Sulfocyanin (SoxE) DUF572 PF04502.8 CDI84452.1 - 7.2 5.7 14.3 8.6 5.4 9.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) CytochromB561_N PF09786.4 CDI84452.1 - 9.9 4.4 17.4 12 4.2 12.1 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Apt1 PF10351.4 CDI84453.1 - 0.55 9.0 29.3 0.79 8.5 20.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Neur_chan_memb PF02932.11 CDI84453.1 - 2.1 8.1 13.6 2.2 8.0 9.4 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DNA_pol_viral_N PF00242.12 CDI84453.1 - 4.5 6.2 34.7 5.9 5.8 24.0 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Band_3_cyto PF07565.8 CDI84453.1 - 5.1 6.5 11.7 5.6 6.3 8.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2201_N PF13203.1 CDI84453.1 - 7.4 5.6 16.8 9 5.3 11.6 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF3807 PF12720.2 CDI84453.1 - 9.2 6.3 17.3 12 6.0 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Metal_resist PF13801.1 CDI84454.1 - 0.015 15.2 0.6 0.015 15.2 0.4 2.1 1 1 1 2 2 2 0 Heavy-metal resistance PAT1 PF09770.4 CDI84454.1 - 2.5 6.2 16.2 2.7 6.0 11.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RAP1 PF07218.6 CDI84454.1 - 4.5 5.2 6.5 5.3 5.0 4.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF605 PF04652.11 CDI84454.1 - 8.5 5.6 15.0 9.4 5.5 10.4 1.0 1 0 0 1 1 1 0 Vta1 like AvrE PF11725.3 CDI84455.1 - 3.6 4.4 9.7 4.2 4.2 6.7 1.0 1 0 0 1 1 1 0 Pathogenicity factor Ribosomal_S21e PF01249.13 CDI84457.1 - 1.8e-38 130.3 0.0 2e-38 130.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Zip PF02535.17 CDI84458.1 - 0.037 13.0 13.3 0.059 12.3 9.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Innate_immun PF12782.2 CDI84458.1 - 6.6 5.8 19.6 2.3 7.3 7.5 2.6 2 0 0 2 2 2 0 Invertebrate innate immunity transcript family Pkinase PF00069.20 CDI84459.1 - 8.2e-18 64.4 0.0 4.4e-13 48.9 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDI84459.1 - 2.3e-06 26.8 0.0 0.00011 21.3 0.0 2.5 2 1 1 3 3 3 2 Protein tyrosine kinase TPR_11 PF13414.1 CDI84463.1 - 3.2e-10 39.5 0.0 7.8e-10 38.2 0.0 1.7 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 CDI84463.1 - 6.5e-10 38.1 0.5 3e-08 32.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat GFO_IDH_MocA PF01408.17 CDI84463.1 - 2.6e-08 34.3 0.0 6.7e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TPR_12 PF13424.1 CDI84463.1 - 3e-08 33.5 0.0 1e-05 25.3 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDI84463.1 - 7.3e-08 31.7 0.0 4.2e-05 23.1 0.0 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDI84463.1 - 2.5e-06 26.8 0.0 0.00041 19.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 CDI84463.1 - 6.6e-05 22.4 0.2 1.1 9.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDI84463.1 - 0.00019 21.7 0.1 0.033 14.8 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDI84463.1 - 0.0032 17.7 0.0 0.0091 16.3 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDI84463.1 - 0.0038 17.8 0.0 0.023 15.3 0.0 2.4 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDI84463.1 - 0.018 14.8 0.0 0.047 13.5 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.1 CDI84463.1 - 0.023 14.8 0.1 6.8 7.1 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDI84463.1 - 0.069 13.0 0.1 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat DUF3497 PF12003.3 CDI84465.1 - 0.048 13.0 0.0 0.067 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3497) Band_7 PF01145.20 CDI84466.1 - 3.2e-29 102.0 0.6 1.1e-28 100.4 0.1 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family PAP2 PF01569.16 CDI84467.1 - 9.3e-19 67.3 3.7 9.3e-19 67.3 2.6 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.1 CDI84467.1 - 0.0068 16.6 0.2 0.0068 16.6 0.2 2.7 3 0 0 3 3 3 1 PAP2 superfamily C-terminal Scs3p PF10261.4 CDI84467.1 - 0.059 12.3 0.2 0.11 11.5 0.1 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF1682 PF07946.9 CDI84468.1 - 1.5e-45 155.4 0.0 2e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) SPARC_Ca_bdg PF10591.4 CDI84469.1 - 0.063 13.3 1.0 0.097 12.7 0.7 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Med15 PF09606.5 CDI84474.1 - 0.016 13.4 49.1 0.024 12.8 34.0 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal His_Phos_1 PF00300.17 CDI84475.1 - 1.2e-13 51.4 2.4 1.2e-13 51.4 1.7 3.2 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) Galactosyl_T PF01762.16 CDI84477.1 - 6.3e-35 120.5 0.0 2.3e-34 118.7 0.0 1.8 1 1 0 1 1 1 1 Galactosyltransferase YajC PF02699.10 CDI84477.1 - 1 9.0 10.4 0.21 11.2 1.4 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit Transket_pyr PF02779.19 CDI84482.1 - 9.5e-46 155.5 0.0 3.4e-45 153.6 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CDI84482.1 - 4.2e-31 107.4 0.0 1.4e-30 105.7 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain MIF PF01187.13 CDI84483.1 - 2.5e-22 79.0 0.1 2.7e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.16 CDI84483.1 - 0.074 12.6 0.0 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 Tautomerase enzyme Tcf25 PF04910.9 CDI84486.1 - 7.1e-14 51.5 2.2 1.6e-13 50.3 1.5 1.6 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TFIIA PF03153.8 CDI84486.1 - 0.66 9.8 12.0 0.91 9.3 8.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RHINO PF15319.1 CDI84486.1 - 5.9 6.6 12.8 8.5 6.1 8.9 1.3 1 0 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein FLO_LFY PF01698.11 CDI84486.1 - 6.8 5.4 8.8 8.9 5.0 6.1 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Herpes_LMP2 PF07415.6 CDI84486.1 - 7.5 5.0 6.2 11 4.5 4.3 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein DUF605 PF04652.11 CDI84486.1 - 8.5 5.6 25.4 12 5.1 17.6 1.1 1 0 0 1 1 1 0 Vta1 like Macoilin PF09726.4 CDI84486.1 - 8.9 4.4 20.7 11 4.0 14.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Ndc1_Nup PF09531.5 CDI84486.1 - 9.1 4.5 10.3 12 4.1 7.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF755 PF05501.6 CDI84487.1 - 7.6 6.6 28.0 1.3 9.0 12.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF572 PF04502.8 CDI84487.1 - 8.4 5.5 10.6 0.62 9.2 3.9 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF572) Peptidase_C12 PF01088.16 CDI84488.1 - 3.8e-08 32.7 1.9 4.3e-08 32.6 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 FxsA PF04186.8 CDI84488.1 - 0.1 12.2 0.1 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein Conotoxin PF02950.12 CDI84488.1 - 1.7 9.5 4.0 3.1 8.6 0.1 2.1 2 0 0 2 2 2 0 Conotoxin La PF05383.12 CDI84490.1 - 4.6e-08 32.7 0.1 0.0014 18.3 0.0 2.3 2 0 0 2 2 2 2 La domain SR-25 PF10500.4 CDI84490.1 - 0.0066 15.9 11.2 0.0066 15.9 7.8 8.5 7 1 1 8 8 8 2 Nuclear RNA-splicing-associated protein CRCB PF02537.10 CDI84491.1 - 0.0052 16.6 0.4 0.0087 15.9 0.2 1.3 1 0 0 1 1 1 1 CrcB-like protein DUF479 PF04336.7 CDI84491.1 - 0.15 12.1 7.5 1.2 9.2 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function, DUF479 Ribosomal_S2 PF00318.15 CDI84492.1 - 5.8e-44 149.8 0.3 6.7e-22 77.7 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Sod_Fe_C PF02777.13 CDI84493.1 - 4.2e-36 123.0 0.1 4.2e-36 123.0 0.1 1.9 2 1 0 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 CDI84493.1 - 2.9e-33 113.9 1.0 2.9e-33 113.9 0.7 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Transaldolase PF00923.14 CDI84494.1 - 2.1e-95 319.1 0.9 2.6e-95 318.8 0.6 1.1 1 0 0 1 1 1 1 Transaldolase DUF599 PF04654.7 CDI84495.1 - 0.052 12.6 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF599 RasGAP_C PF03836.10 CDI84495.1 - 0.12 12.0 0.3 0.2 11.3 0.2 1.3 1 0 0 1 1 1 0 RasGAP C-terminus Ribosomal_60s PF00428.14 CDI84497.1 - 0.072 13.4 5.6 0.24 11.7 0.2 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Apt1 PF10351.4 CDI84497.1 - 0.18 10.6 0.0 0.18 10.6 0.0 2.2 3 0 0 3 3 3 0 Golgi-body localisation protein domain PAT1 PF09770.4 CDI84498.1 - 0.48 8.5 15.8 0.8 7.8 11.0 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CTDII PF01556.13 CDI84500.1 - 1.3e-29 101.9 0.5 1.7e-24 85.5 0.2 2.6 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 CDI84500.1 - 9.7e-25 86.0 1.5 1.6e-24 85.3 1.0 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 CDI84500.1 - 0.0089 16.0 3.7 0.017 15.1 2.6 1.4 1 0 0 1 1 1 1 DnaJ central domain gag-asp_proteas PF13975.1 CDI84501.1 - 6.8e-07 29.0 0.0 1.6e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 CDI84501.1 - 7.2e-06 26.4 0.0 5e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.6 CDI84501.1 - 0.0011 18.8 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 CDI84501.1 - 0.0039 17.0 0.0 0.008 16.0 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF2237 PF09996.4 CDI84501.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) Chromo PF00385.19 CDI84502.1 - 3.1e-15 55.5 0.0 6e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.22 CDI84502.1 - 1.1e-07 31.3 0.0 2.4e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 CDI84502.1 - 2.6e-06 27.5 0.0 7.2e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain N2227 PF07942.7 CDI84503.1 - 2.6e-83 279.1 1.5 1.1e-82 277.1 0.0 2.1 2 0 0 2 2 2 1 N2227-like protein SAGA-Tad1 PF12767.2 CDI84503.1 - 0.96 9.0 43.3 3.1 7.3 19.5 3.3 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit GAGA_bind PF06217.7 CDI84503.1 - 2.1 8.2 35.0 3.3 7.5 19.8 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Mem_trans PF03547.13 CDI84503.1 - 3.1 6.0 6.8 0.061 11.6 0.2 1.4 2 0 0 2 2 2 0 Membrane transport protein LMBR1 PF04791.11 CDI84503.1 - 5.2 5.5 14.2 0.56 8.7 6.4 1.7 2 0 0 2 2 2 0 LMBR1-like membrane protein SGT1 PF07093.6 CDI84503.1 - 7 4.9 36.0 0.096 11.0 5.9 2.8 1 1 1 2 2 2 0 SGT1 protein TraG-D_C PF12696.2 CDI84504.1 - 0.1 12.4 1.1 0.21 11.4 0.8 1.5 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG Ribosomal_60s PF00428.14 CDI84506.1 - 0.25 11.7 43.5 0.37 11.2 9.5 4.5 5 0 0 5 5 5 0 60s Acidic ribosomal protein FLO_LFY PF01698.11 CDI84506.1 - 2.4 6.8 7.2 3.5 6.3 5.0 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein CDC45 PF02724.9 CDI84506.1 - 3.3 5.6 13.6 5.3 4.9 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.4 CDI84506.1 - 3.5 6.3 18.6 6.6 5.4 11.4 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain Rep_fac-A_3 PF08661.6 CDI84507.1 - 3.3e-08 33.4 0.0 3.7e-08 33.2 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF4407 PF14362.1 CDI84508.1 - 0.19 10.6 10.4 0.082 11.8 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Bud13 PF09736.4 CDI84508.1 - 0.35 11.1 8.8 0.048 13.9 1.1 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Serinc PF03348.10 CDI84508.1 - 0.36 9.5 4.2 0.23 10.0 1.4 1.6 2 0 0 2 2 2 0 Serine incorporator (Serinc) OAD_gamma PF04277.8 CDI84508.1 - 1 9.7 7.4 1.2 9.5 3.9 2.0 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Med15 PF09606.5 CDI84508.1 - 2.2 6.3 30.5 3.1 5.8 21.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDI84508.1 - 3.7 5.6 24.6 4.4 5.4 17.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3037 PF11236.3 CDI84509.1 - 0.18 11.8 4.7 0.18 11.8 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) Chromo PF00385.19 CDI84510.1 - 1.8e-06 27.5 0.1 3.4e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Phostensin_N PF13916.1 CDI84512.1 - 1.2 9.2 10.3 2.3 8.2 7.1 1.7 1 1 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Bim_N PF06773.6 CDI84513.1 - 2.4 7.9 18.7 1.3 8.8 1.3 5.2 2 2 1 3 3 3 0 Bim protein N-terminus RINGv PF12906.2 CDI84514.1 - 3.4e-13 49.3 4.8 3.4e-13 49.3 3.3 2.3 2 0 0 2 2 2 1 RING-variant domain FHA PF00498.21 CDI84514.1 - 2.6e-05 24.2 1.0 0.00054 20.0 0.4 2.4 2 0 0 2 2 2 1 FHA domain DDRGK PF09756.4 CDI84515.1 - 0.17 11.3 9.6 0.34 10.2 6.7 1.4 1 0 0 1 1 1 0 DDRGK domain RNA_pol_Rpb4 PF03874.11 CDI84515.1 - 1 9.3 4.7 2.2 8.3 3.3 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb4 IncA PF04156.9 CDI84515.1 - 3.9 7.0 20.5 1.7 8.1 12.2 1.9 2 0 0 2 2 2 0 IncA protein Ribosomal_60s PF00428.14 CDI84516.1 - 9.9e-20 70.7 9.4 2.1e-19 69.7 6.5 1.5 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L10 PF00466.15 CDI84516.1 - 3.2e-07 30.2 0.0 5.4e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 TSP9 PF11493.3 CDI84516.1 - 0.011 16.2 0.2 0.017 15.6 0.2 1.3 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 Myc_N PF01056.13 CDI84516.1 - 0.033 13.3 0.1 0.045 12.9 0.1 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF3138 PF11336.3 CDI84516.1 - 0.37 8.9 2.9 0.46 8.6 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) WD40 PF00400.27 CDI84517.1 - 8.6e-37 123.7 17.1 1.6e-09 37.2 0.8 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat zf-CCCH PF00642.19 CDI84519.1 - 2e-11 43.2 16.5 2.1e-07 30.4 1.0 4.3 3 1 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_L6e PF01159.14 CDI84521.1 - 8.6e-36 122.4 1.3 1.3e-35 121.9 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L6e Ycf54 PF10674.4 CDI84521.1 - 0.16 12.1 0.5 0.26 11.4 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Kelch_3 PF13415.1 CDI84522.1 - 1.3e-19 69.7 2.5 3.1e-05 24.0 0.0 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 CDI84522.1 - 4.5e-17 61.5 5.1 5.1e-07 29.3 0.0 4.7 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 CDI84522.1 - 4.3e-11 42.5 0.2 0.012 15.5 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.1 CDI84522.1 - 1.4e-09 37.6 2.3 0.051 13.7 0.0 5.1 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.20 CDI84522.1 - 3.3e-07 29.7 0.0 0.021 14.3 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 CDI84522.1 - 0.0015 18.2 4.1 3.3 7.6 0.3 4.6 6 0 0 6 6 6 2 Kelch motif ECM11 PF15463.1 CDI84522.1 - 0.0058 16.9 3.3 0.0058 16.9 2.3 2.2 2 0 0 2 2 2 1 Extracellular mutant protein 11 RBD-FIP PF09457.5 CDI84522.1 - 0.14 11.9 0.8 0.64 9.8 0.0 2.1 2 0 0 2 2 2 0 FIP domain DUF4391 PF14335.1 CDI84522.1 - 0.34 10.2 2.8 0.51 9.6 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) CEP170_C PF15308.1 CDI84523.1 - 0.11 10.7 1.6 0.15 10.2 1.1 1.1 1 0 0 1 1 1 0 CEP170 C-terminus Ribosomal_L28 PF00830.14 CDI84524.1 - 1.9e-20 72.4 2.4 1e-19 70.1 0.9 2.2 2 0 0 2 2 2 1 Ribosomal L28 family RRM_6 PF14259.1 CDI84525.1 - 9.8e-22 76.7 0.0 2e-07 30.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDI84525.1 - 3e-18 65.1 0.0 1.8e-05 24.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDI84525.1 - 3.5e-09 36.3 0.0 0.052 13.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP21_like_P PF12230.3 CDI84533.1 - 0.031 13.7 0.1 0.049 13.1 0.1 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein LcrG PF07216.7 CDI84533.1 - 0.11 12.5 2.4 0.12 12.4 0.7 1.8 2 0 0 2 2 2 0 LcrG protein DUF2489 PF10675.4 CDI84533.1 - 2.2 7.9 7.3 4.1 7.0 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) Kinesin PF00225.18 CDI84534.1 - 9.3e-62 208.6 0.0 2.3e-42 144.8 0.0 2.7 3 0 0 3 3 3 2 Kinesin motor domain Adeno_PIX PF03955.9 CDI84535.1 - 0.034 14.6 0.3 0.034 14.6 0.2 2.0 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Med17 PF10156.4 CDI84535.1 - 0.059 11.6 7.6 0.062 11.5 5.2 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex DUF2675 PF11247.3 CDI84535.1 - 0.1 12.6 0.5 0.14 12.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2675) Prismane PF03063.15 CDI84535.1 - 0.13 10.5 2.2 0.16 10.2 1.5 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Atg14 PF10186.4 CDI84535.1 - 3.1 6.6 14.1 4.2 6.2 9.8 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FLO_LFY PF01698.11 CDI84535.1 - 4 6.1 11.7 4.7 5.9 8.1 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein PBP_sp32 PF07222.7 CDI84535.1 - 7.2 5.7 13.9 9.5 5.3 9.6 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 zf-RING_2 PF13639.1 CDI84536.1 - 7.4e-10 38.4 4.6 7.7e-10 38.4 1.7 2.2 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CDI84536.1 - 3.4e-06 27.0 0.9 8.5e-06 25.7 0.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CDI84536.1 - 1.3e-05 24.7 2.5 1.6e-05 24.4 0.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDI84536.1 - 9.8e-05 22.3 3.0 9.8e-05 22.3 2.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDI84536.1 - 0.00067 19.3 1.2 0.00067 19.3 0.8 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 CDI84536.1 - 0.001 18.8 1.4 0.0033 17.2 1.0 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 CDI84536.1 - 0.0072 15.9 1.9 0.019 14.6 1.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 CDI84536.1 - 0.064 13.3 1.3 0.14 12.2 0.9 1.6 1 0 0 1 1 1 0 RING-variant domain Macoilin PF09726.4 CDI84536.1 - 0.065 11.5 14.8 0.084 11.1 0.1 2.3 2 0 0 2 2 2 0 Transmembrane protein FtsJ PF01728.14 CDI84537.1 - 2.1e-58 197.2 0.0 7e-58 195.5 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Apc15p PF05841.6 CDI84537.1 - 0.0025 18.5 2.9 0.0025 18.5 2.0 3.4 3 0 0 3 3 3 1 Apc15p protein Rtf2 PF04641.7 CDI84537.1 - 0.034 13.3 0.1 0.034 13.3 0.1 2.6 2 1 1 3 3 3 0 Rtf2 RING-finger Methyltrans_Mon PF14314.1 CDI84537.1 - 0.063 11.1 0.0 0.088 10.6 0.0 1.1 1 0 0 1 1 1 0 Virus-capping methyltransferase Methyltransf_23 PF13489.1 CDI84537.1 - 0.096 12.4 0.0 0.56 9.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain RINT1_TIP1 PF04437.8 CDI84537.1 - 0.4 9.1 4.0 0.66 8.4 2.8 1.2 1 0 0 1 1 1 0 RINT-1 / TIP-1 family Rifin_STEVOR PF02009.11 CDI84537.1 - 0.4 10.2 12.0 16 5.0 6.9 2.5 2 0 0 2 2 2 0 Rifin/stevor family Spt20 PF12090.3 CDI84538.1 - 3.1 7.0 16.0 0.99 8.7 2.2 2.8 3 0 0 3 3 3 0 Spt20 family UCH PF00443.24 CDI84539.1 - 2.6e-29 102.1 0.0 4e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 CDI84539.1 - 2.2e-06 26.9 0.0 4.1e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UCH_1 PF13423.1 CDI84539.1 - 7.3e-06 25.6 0.7 0.018 14.4 0.1 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Secretin_N_2 PF07655.8 CDI84539.1 - 0.39 11.1 14.5 3.3 8.1 3.3 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Fasciclin PF02469.17 CDI84540.1 - 0.0023 17.9 0.0 0.0048 16.8 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain Trypsin_2 PF13365.1 CDI84541.1 - 2.2e-15 56.7 0.1 2.2e-15 56.7 0.1 2.1 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.21 CDI84541.1 - 3e-15 56.3 0.3 5e-15 55.6 0.2 1.4 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 CDI84541.1 - 3.5e-08 33.2 0.0 4.7e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 CDI84541.1 - 8.2e-05 22.7 0.0 0.00019 21.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S7 PF00949.16 CDI84541.1 - 0.00077 18.8 0.0 0.00077 18.8 0.0 2.0 2 0 0 2 2 2 1 Peptidase S7, Flavivirus NS3 serine protease Peptidase_C2 PF00648.16 CDI84541.1 - 0.062 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease Peptidase_S46 PF10459.4 CDI84541.1 - 0.077 11.4 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 Ribosomal_60s PF00428.14 CDI84541.1 - 6 7.3 10.8 13 6.2 7.5 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Leu_Phe_trans PF03588.9 CDI84543.1 - 2.6e-13 49.4 0.0 2.3e-12 46.3 0.0 2.1 2 0 0 2 2 2 1 Leucyl/phenylalanyl-tRNA protein transferase zf-B_box PF00643.19 CDI84544.1 - 1.7e-10 40.6 13.5 4.8e-05 23.1 4.9 2.5 2 0 0 2 2 2 2 B-box zinc finger Cript PF10235.4 CDI84544.1 - 0.00062 20.0 2.6 0.0014 18.9 1.8 1.5 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT PARP PF00644.15 CDI84544.1 - 0.095 12.1 0.4 0.2 11.0 0.3 1.6 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain PseudoU_synth_1 PF01416.15 CDI84545.1 - 0.0065 16.8 4.0 0.021 15.2 1.6 2.9 2 1 0 2 2 2 1 tRNA pseudouridine synthase Shadoo PF14999.1 CDI84546.1 - 0.0018 18.1 3.4 0.002 17.9 2.4 1.2 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective FAM222A PF15258.1 CDI84546.1 - 0.0048 16.1 0.9 0.0053 16.0 0.6 1.0 1 0 0 1 1 1 1 Protein family of FAM222A DUF212 PF02681.9 CDI84546.1 - 0.013 15.2 0.3 0.018 14.8 0.2 1.2 1 0 0 1 1 1 0 Divergent PAP2 family Med15 PF09606.5 CDI84546.1 - 0.067 11.3 8.5 0.071 11.3 5.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3597 PF12200.3 CDI84546.1 - 0.63 10.4 4.0 0.79 10.1 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) FxsA PF04186.8 CDI84546.1 - 1.7 8.2 4.0 1.7 8.2 1.8 1.7 1 1 1 2 2 2 0 FxsA cytoplasmic membrane protein MSP1_C PF07462.6 CDI84546.1 - 2 6.6 3.9 2.4 6.4 2.7 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus AAA PF00004.24 CDI84547.1 - 1.8e-09 37.9 0.5 1.3e-08 35.0 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 CDI84547.1 - 3.1e-05 23.6 1.4 3.1e-05 23.6 0.9 2.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 CDI84547.1 - 5.4e-05 23.3 0.4 5.4e-05 23.3 0.3 2.9 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.9 CDI84547.1 - 0.011 15.4 0.0 0.038 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 CDI84547.1 - 0.035 13.7 0.0 0.077 12.6 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_17 PF13207.1 CDI84547.1 - 0.23 12.2 0.0 0.46 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDI84547.1 - 0.25 11.6 0.0 0.72 10.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma70_ner PF04546.8 CDI84548.1 - 0.013 15.1 14.5 0.014 15.0 10.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.4 CDI84548.1 - 0.017 13.8 24.5 0.018 13.7 17.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 CDI84548.1 - 0.15 12.3 18.7 0.22 11.8 13.0 1.3 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2722 PF10846.3 CDI84548.1 - 0.18 10.8 2.6 0.16 10.9 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Daxx PF03344.10 CDI84548.1 - 0.22 9.9 20.4 0.22 9.9 14.2 1.0 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 CDI84548.1 - 0.25 9.3 14.5 0.28 9.1 10.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.5 CDI84548.1 - 0.69 9.9 6.7 0.78 9.7 4.6 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TRAP_alpha PF03896.11 CDI84548.1 - 0.84 8.5 11.4 0.83 8.5 7.9 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2796 PF10986.3 CDI84548.1 - 1 9.3 4.9 1 9.3 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Nop25 PF09805.4 CDI84548.1 - 1 9.4 12.0 1.2 9.2 8.3 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) DUF1510 PF07423.6 CDI84548.1 - 2.2 7.5 13.4 2.5 7.4 9.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC27 PF09507.5 CDI84548.1 - 2.5 7.2 8.8 2.6 7.1 6.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4637 PF15470.1 CDI84548.1 - 2.5 7.6 14.9 2.8 7.5 10.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pox_Ag35 PF03286.9 CDI84548.1 - 2.9 7.3 8.4 3.1 7.2 5.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CobT PF06213.7 CDI84548.1 - 3 6.9 23.1 3.3 6.7 16.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 CDI84548.1 - 3 5.6 24.7 3.2 5.5 17.1 1.0 1 0 0 1 1 1 0 Nop14-like family CENP-T PF15511.1 CDI84548.1 - 3.9 6.5 17.0 4.6 6.3 11.8 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T SpoIIIAH PF12685.2 CDI84548.1 - 4.6 6.6 7.1 4.9 6.6 4.9 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein TLP-20 PF06088.6 CDI84548.1 - 4.8 6.8 6.5 5.7 6.5 4.5 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) U79_P34 PF03064.11 CDI84548.1 - 5.9 6.3 11.0 6.9 6.1 7.6 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Mpp10 PF04006.7 CDI84548.1 - 6.3 5.0 20.6 7 4.8 14.3 1.0 1 0 0 1 1 1 0 Mpp10 protein eIF-3c_N PF05470.7 CDI84548.1 - 6.7 4.6 10.1 7 4.5 7.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Rad60-SLD_2 PF13881.1 CDI84549.1 - 3.6e-05 23.6 0.0 4.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 CDI84549.1 - 0.0018 17.5 0.0 0.019 14.3 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family SR-25 PF10500.4 CDI84550.1 - 0.0019 17.7 4.7 0.0019 17.7 3.3 4.9 4 1 1 5 5 5 2 Nuclear RNA-splicing-associated protein Pkinase PF00069.20 CDI84550.1 - 0.057 12.5 0.0 0.057 12.5 0.0 2.1 2 1 0 2 2 2 0 Protein kinase domain Sporozoite_P67 PF05642.6 CDI84550.1 - 0.56 7.9 9.2 0.11 10.3 3.3 1.7 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Exo5 PF09810.4 CDI84551.1 - 1.8e-39 135.8 0.0 1.8e-39 135.8 0.0 3.5 2 2 0 2 2 2 1 Exonuclease V - a 5' deoxyribonuclease Metallothio_5 PF02067.10 CDI84552.1 - 0.16 12.0 8.4 0.55 10.3 5.8 1.9 1 0 0 1 1 1 0 Metallothionein family 5 DUF3984 PF13136.1 CDI84554.1 - 0.0023 17.2 2.0 0.0026 17.0 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) BAF1_ABF1 PF04684.8 CDI84554.1 - 0.018 13.9 16.6 0.023 13.5 11.5 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Med15 PF09606.5 CDI84554.1 - 0.018 13.2 15.3 0.023 12.9 10.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal LCD1 PF09798.4 CDI84554.1 - 0.035 12.0 1.4 0.031 12.2 1.0 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein Pex16 PF08610.5 CDI84554.1 - 0.062 12.2 0.8 0.063 12.2 0.6 1.0 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Activator_LAG-3 PF11498.3 CDI84554.1 - 0.82 8.3 21.6 1.1 7.9 15.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CDK2AP PF09806.4 CDI84554.1 - 0.82 9.8 10.9 1 9.5 7.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein DUF4175 PF13779.1 CDI84554.1 - 1.1 6.8 19.3 1.4 6.5 13.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4407 PF14362.1 CDI84554.1 - 1.3 7.9 9.7 1.6 7.6 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.10 CDI84554.1 - 1.3 8.5 8.4 1.9 8.0 5.8 1.2 1 0 0 1 1 1 0 Septum formation initiator DUF3138 PF11336.3 CDI84554.1 - 4.6 5.3 12.1 5.3 5.0 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) UPF0560 PF10577.4 CDI84554.1 - 5.6 5.0 10.1 6.8 4.8 7.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SMC_N PF02463.14 CDI84555.1 - 8.5e-26 90.5 0.3 8.5e-26 90.5 0.2 3.5 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CDI84555.1 - 1.5e-22 79.7 0.0 1.5e-22 79.7 0.0 3.7 5 0 0 5 5 5 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 CDI84555.1 - 1.5e-05 25.1 0.1 2.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDI84555.1 - 1.7e-05 24.2 0.0 3.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Med15 PF09606.5 CDI84555.1 - 0.00032 19.0 12.9 0.00032 19.0 8.9 4.8 3 2 1 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal AAA_15 PF13175.1 CDI84555.1 - 0.0091 15.0 0.0 0.0091 15.0 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 CDI84555.1 - 0.12 13.1 0.0 0.53 11.1 0.0 2.2 1 0 0 1 1 1 0 AAA domain Ribosomal_60s PF00428.14 CDJ26762.1 - 1.1 9.6 19.3 1.5 9.2 3.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein HSP70 PF00012.15 CDJ26762.1 - 2.3 6.0 17.1 3.4 5.4 11.9 1.3 1 0 0 1 1 1 0 Hsp70 protein PRP38 PF03371.10 CDJ26763.1 - 8e-46 155.8 0.1 1.3e-45 155.1 0.0 1.3 1 0 0 1 1 1 1 PRP38 family CDC45 PF02724.9 CDJ26763.1 - 0.0015 16.6 3.2 0.0015 16.6 2.2 2.2 2 0 0 2 2 2 1 CDC45-like protein SR-25 PF10500.4 CDJ26764.1 - 0.0064 15.9 10.6 0.0064 15.9 7.3 1.7 1 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein Pet127 PF08634.5 CDJ26764.1 - 0.033 13.3 0.8 0.044 12.9 0.6 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet127 bZIP_C PF12498.3 CDJ26764.1 - 1.8 9.8 5.0 10 7.3 3.5 2.0 1 1 0 1 1 1 0 Basic leucine-zipper C terminal CAF-1_p150 PF11600.3 CDJ26764.1 - 7.7 5.8 7.1 1.1 8.5 1.7 1.9 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF2391 PF09622.5 CDJ26765.1 - 0.014 14.5 1.3 0.014 14.5 0.9 2.6 2 1 1 3 3 3 0 Putative integral membrane protein (DUF2391) FAM60A PF15396.1 CDJ26765.1 - 1.1 9.0 9.4 6.2 6.5 2.3 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF3319 PF11782.3 CDJ26765.1 - 1.4 8.8 4.4 0.69 9.7 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3319) DUF3138 PF11336.3 CDJ26766.1 - 4.1 5.4 7.2 5.8 4.9 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Corona_nucleoca PF00937.13 CDJ26766.1 - 10 4.9 8.3 12 4.6 5.7 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DEAD PF00270.24 CDJ26768.1 - 2.1e-25 89.1 0.2 2.8e-24 85.4 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDJ26768.1 - 4.1e-15 55.4 0.1 1.8e-14 53.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 CDJ26768.1 - 0.006 15.0 4.2 0.022 13.1 0.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1253) AAA_22 PF13401.1 CDJ26768.1 - 0.012 15.7 0.8 0.75 9.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain Peptidase_M24 PF00557.19 CDJ26769.1 - 5.6e-20 71.7 2.1 2.1e-15 56.8 0.1 2.2 2 0 0 2 2 2 2 Metallopeptidase family M24 FMN_red PF03358.10 CDJ26769.1 - 0.022 14.2 0.6 0.05 13.0 0.4 1.5 1 0 0 1 1 1 0 NADPH-dependent FMN reductase CDK2AP PF09806.4 CDJ26769.1 - 0.042 14.0 2.1 0.053 13.7 1.4 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein TPP_enzyme_M PF00205.17 CDJ26769.1 - 0.092 12.5 1.3 0.2 11.4 0.9 1.5 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DUF755 PF05501.6 CDJ26771.1 - 0.0067 16.4 17.2 0.0076 16.2 11.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF755) Med15 PF09606.5 CDJ26771.1 - 0.015 13.5 22.4 0.015 13.5 15.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1510 PF07423.6 CDJ26771.1 - 0.1 11.9 7.6 0.12 11.7 5.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF1314 PF07013.6 CDJ26771.1 - 0.1 11.9 2.2 0.12 11.8 1.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) SpoIIIAH PF12685.2 CDJ26771.1 - 0.11 11.9 10.9 0.12 11.8 7.5 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein Ly49 PF08391.5 CDJ26771.1 - 0.12 12.5 2.1 0.12 12.4 1.4 1.2 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Dehydrin PF00257.14 CDJ26771.1 - 0.12 12.6 8.3 0.15 12.3 5.7 1.1 1 0 0 1 1 1 0 Dehydrin Herpes_UL35 PF04496.7 CDJ26771.1 - 0.14 12.4 1.2 0.16 12.1 0.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL35 family Neur_chan_memb PF02932.11 CDJ26771.1 - 0.14 12.0 4.4 0.15 11.9 3.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mlf1IP PF10248.4 CDJ26771.1 - 0.16 11.5 5.7 0.17 11.5 3.9 1.0 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein RskA PF10099.4 CDJ26771.1 - 0.2 11.3 8.0 0.26 11.0 5.6 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DivIC PF04977.10 CDJ26771.1 - 0.26 10.8 6.9 0.31 10.5 4.8 1.2 1 0 0 1 1 1 0 Septum formation initiator Spt20 PF12090.3 CDJ26771.1 - 0.27 10.5 6.1 0.26 10.6 4.2 1.2 1 0 0 1 1 1 0 Spt20 family DUF3260 PF11658.3 CDJ26771.1 - 0.29 9.2 5.7 0.28 9.2 3.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) EphA2_TM PF14575.1 CDJ26771.1 - 0.36 11.2 5.8 0.4 11.1 4.0 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FxsA PF04186.8 CDJ26771.1 - 0.41 10.2 5.1 0.54 9.8 3.6 1.1 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein CcmD PF04995.9 CDJ26771.1 - 0.46 10.2 5.3 0.94 9.2 3.7 1.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) FRQ PF09421.5 CDJ26771.1 - 0.59 7.8 10.1 0.63 7.7 7.0 1.0 1 0 0 1 1 1 0 Frequency clock protein Activator_LAG-3 PF11498.3 CDJ26771.1 - 0.72 8.5 22.2 0.77 8.4 15.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4557 PF15101.1 CDJ26771.1 - 0.75 9.5 11.0 0.81 9.4 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) CDK2AP PF09806.4 CDJ26771.1 - 1.3 9.2 13.3 1.5 9.0 9.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein RED_N PF07808.8 CDJ26771.1 - 1.3 8.1 7.8 1.4 8.1 5.4 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF3357 PF11837.3 CDJ26771.1 - 1.4 8.7 7.8 4.5 7.1 5.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) FCP1_C PF09309.5 CDJ26771.1 - 1.5 8.0 10.2 1.9 7.7 7.0 1.2 1 0 0 1 1 1 0 FCP1, C-terminal DUF775 PF05603.7 CDJ26771.1 - 1.8 8.0 10.0 2.1 7.8 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Apc15p PF05841.6 CDJ26771.1 - 2.2 8.9 12.4 2.5 8.8 8.6 1.0 1 0 0 1 1 1 0 Apc15p protein FimP PF09766.4 CDJ26771.1 - 2.3 7.2 11.0 2.4 7.1 7.6 1.1 1 0 0 1 1 1 0 Fms-interacting protein TFIIA PF03153.8 CDJ26771.1 - 2.3 8.0 15.1 2.4 7.9 10.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Conotoxin PF02950.12 CDJ26771.1 - 2.9 8.7 6.5 8 7.3 4.5 1.8 1 1 0 1 1 1 0 Conotoxin ABC_tran_2 PF12848.2 CDJ26771.1 - 3 7.7 12.4 3.4 7.5 8.6 1.2 1 0 0 1 1 1 0 ABC transporter CDK5_activator PF03261.10 CDJ26771.1 - 4.6 6.4 11.4 5.2 6.3 7.9 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF853 PF05872.7 CDJ26771.1 - 4.7 5.4 8.8 4.7 5.4 6.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) BRF1 PF07741.8 CDJ26771.1 - 5.1 7.3 8.9 5.9 7.1 6.2 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain UPF0561 PF10573.4 CDJ26771.1 - 5.9 6.7 8.5 7.2 6.4 5.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Serinc PF03348.10 CDJ26771.1 - 5.9 5.4 5.8 6.3 5.3 4.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Claudin_2 PF13903.1 CDJ26771.1 - 7 6.3 6.3 9.1 5.9 4.3 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4407 PF14362.1 CDJ26771.1 - 9.3 5.1 10.3 10 4.9 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OB_NTP_bind PF07717.11 CDJ26775.1 - 4.9e-26 90.7 0.0 1.1e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CDJ26775.1 - 5.7e-23 80.8 4.0 6.4e-23 80.7 0.0 2.8 2 1 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 CDJ26775.1 - 1.9e-11 43.6 0.0 4.8e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDJ26775.1 - 3.1e-06 27.3 0.6 4.3e-05 23.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 CDJ26775.1 - 9e-05 21.4 0.0 0.00019 20.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.24 CDJ26775.1 - 0.0036 16.8 0.8 0.033 13.6 0.5 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase cobW PF02492.14 CDJ26775.1 - 0.07 12.5 0.0 0.78 9.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 CDJ26775.1 - 0.079 12.8 0.0 0.28 11.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CDJ26775.1 - 0.12 12.0 1.1 0.35 10.5 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase Med3 PF11593.3 CDJ26775.1 - 1.3 8.2 11.9 2.3 7.3 8.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal AAA_23 PF13476.1 CDJ26775.1 - 3.6 7.8 0.0 3.6 7.8 0.0 2.7 2 1 0 2 2 1 0 AAA domain Serpin PF00079.15 CDJ26776.1 - 6.6e-71 239.3 0.0 7.8e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-C2H2 PF00096.21 CDJ26777.1 - 0.012 15.9 0.5 0.06 13.7 0.3 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDJ26777.1 - 0.018 15.3 0.4 0.018 15.3 0.3 3.4 2 0 0 2 2 2 0 C2H2-type zinc finger Cpn60_TCP1 PF00118.19 CDJ26779.1 - 2.6e-37 128.5 0.0 2.9e-37 128.4 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family eIF-6 PF01912.13 CDJ26779.1 - 0.012 14.7 0.0 0.015 14.3 0.0 1.1 1 0 0 1 1 1 0 eIF-6 family DUF4358 PF14270.1 CDJ26780.1 - 0.018 14.8 0.5 0.018 14.8 0.4 7.0 7 1 0 7 7 7 0 Domain of unknown function (DUF4358) Methyltransf_23 PF13489.1 CDJ26780.1 - 0.15 11.7 0.0 0.15 11.7 0.0 4.0 6 0 0 6 6 6 0 Methyltransferase domain VCBS PF13517.1 CDJ26781.1 - 5.6e-18 65.0 5.2 3.7e-07 30.4 0.3 6.7 6 1 1 7 7 7 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 CDJ26781.1 - 5.9e-14 51.2 19.0 0.00011 21.8 1.8 6.8 7 0 0 7 7 7 4 FG-GAP repeat FimP PF09766.4 CDJ26781.1 - 0.0045 16.1 5.3 0.0045 16.1 3.7 4.5 4 1 0 4 4 4 2 Fms-interacting protein DUF4083 PF13314.1 CDJ26781.1 - 0.11 12.3 0.6 2.2 8.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) DUF1467 PF07330.7 CDJ26781.1 - 0.24 11.2 1.4 2.8 7.7 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) EF-hand_5 PF13202.1 CDJ26781.1 - 7 6.1 5.7 16 5.0 0.0 3.2 3 0 0 3 3 3 0 EF hand EphA2_TM PF14575.1 CDJ26781.1 - 9 6.7 0.0 9 6.7 0.0 5.8 6 0 0 6 6 6 0 Ephrin type-A receptor 2 transmembrane domain DUF212 PF02681.9 CDJ26782.1 - 0.0076 15.9 0.2 0.036 13.8 0.1 2.1 1 0 0 1 1 1 1 Divergent PAP2 family Adeno_E4 PF05385.6 CDJ26782.1 - 0.0099 15.8 0.3 0.045 13.7 0.0 2.2 2 0 0 2 2 2 1 Mastadenovirus early E4 13 kDa protein VP4_haemagglut PF00426.13 CDJ26782.1 - 0.015 13.3 7.1 0.026 12.5 4.9 1.3 1 0 0 1 1 1 0 Outer Capsid protein VP4 (Hemagglutinin) Cellulose_synt PF03552.9 CDJ26782.1 - 2.2 6.4 3.2 4 5.6 2.2 1.4 1 0 0 1 1 1 0 Cellulose synthase Nop14 PF04147.7 CDJ26782.1 - 3.1 5.5 50.9 0.86 7.4 25.1 3.1 3 0 0 3 3 3 0 Nop14-like family CDC27 PF09507.5 CDJ26785.1 - 6.2 5.9 9.8 8.7 5.4 6.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CAF-1_p150 PF11600.3 CDJ26786.1 - 0.00095 18.6 0.8 0.00095 18.6 0.6 2.7 3 0 0 3 3 3 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Plasmodium_Vir PF05795.6 CDJ26786.1 - 0.0053 16.0 5.0 0.0074 15.5 2.4 2.0 1 1 1 2 2 2 1 Plasmodium vivax Vir protein Hid1 PF12722.2 CDJ26786.1 - 1.8 6.1 33.8 0.43 8.1 7.8 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein CDC45 PF02724.9 CDJ26786.1 - 2.4 6.1 23.9 0.25 9.3 1.5 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF966 PF06136.8 CDJ26786.1 - 3.6 6.9 29.3 0.96 8.7 9.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Pox_Ag35 PF03286.9 CDJ26786.1 - 4.5 6.7 21.7 1.5 8.3 0.8 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Tim54 PF11711.3 CDJ26786.1 - 6.2 5.3 17.6 2 6.9 0.9 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 BAF1_ABF1 PF04684.8 CDJ26787.1 - 0.00018 20.5 9.9 0.00018 20.5 6.9 4.9 3 2 2 5 5 5 2 BAF1 / ABF1 chromatin reorganising factor Herpes_DNAp_acc PF04929.7 CDJ26787.1 - 0.0022 17.0 1.1 0.0022 17.0 0.8 3.1 2 1 1 3 3 3 1 Herpes DNA replication accessory factor PRP1_N PF06424.7 CDJ26787.1 - 0.1 12.9 0.2 0.1 12.9 0.1 4.3 3 1 1 4 4 4 0 PRP1 splicing factor, N-terminal SURF6 PF04935.7 CDJ26787.1 - 0.19 10.9 53.1 0.22 10.7 5.4 3.2 3 0 0 3 3 3 0 Surfeit locus protein 6 FimP PF09766.4 CDJ26787.1 - 3.2 6.7 70.5 0.38 9.7 4.1 4.1 4 0 0 4 4 4 0 Fms-interacting protein DUF1467 PF07330.7 CDJ26787.1 - 7.9 6.3 5.4 20 5.0 0.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) Ribosomal_60s PF00428.14 CDJ26788.1 - 0.0024 18.2 6.2 0.0024 18.2 4.3 2.6 2 0 0 2 2 2 2 60s Acidic ribosomal protein DUF3722 PF12519.3 CDJ26788.1 - 0.16 11.1 0.6 0.82 8.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3722) Dynein_heavy PF03028.10 CDJ26789.1 - 5.5e-135 451.1 0.0 6.7e-93 312.0 0.0 2.0 2 0 0 2 2 2 2 Dynein heavy chain and region D6 of dynein motor V-ATPase_H_C PF11698.3 CDJ26790.1 - 1.6e-40 137.7 0.8 1.6e-40 137.7 0.6 2.3 2 1 0 2 2 2 1 V-ATPase subunit H PAT1 PF09770.4 CDJ26790.1 - 0.013 13.7 54.7 0.017 13.4 37.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SPX PF03105.14 CDJ26790.1 - 1.2 8.7 15.8 1.9 8.2 10.9 1.2 1 0 0 1 1 1 0 SPX domain V_ATPase_I PF01496.14 CDJ26790.1 - 2 6.1 14.8 2.9 5.6 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CHDCT2 PF08074.6 CDJ26790.1 - 3.3 7.4 13.8 5.8 6.6 9.6 1.3 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain LMBR1 PF04791.11 CDJ26790.1 - 3.6 6.0 6.8 5 5.5 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1675 PF07897.6 CDJ26790.1 - 5 6.9 8.9 9 6.0 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) HAUS4 PF14735.1 CDJ26791.1 - 0.007 15.7 3.6 0.011 15.0 2.5 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 Methyltransf_7 PF03492.10 CDJ26791.1 - 0.025 13.3 0.0 0.037 12.7 0.0 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase Secretin_N_2 PF07655.8 CDJ26791.1 - 0.18 12.2 2.2 3.3 8.1 0.2 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain SprA-related PF12118.3 CDJ26791.1 - 1.3 8.2 13.7 2 7.6 9.5 1.2 1 0 0 1 1 1 0 SprA-related family OmpH PF03938.9 CDJ26791.1 - 3.7 7.4 17.2 47 3.8 11.9 2.2 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) PP2C PF00481.16 CDJ26793.1 - 2.1e-30 105.9 8.2 2.6e-29 102.3 2.4 4.5 4 1 1 5 5 5 3 Protein phosphatase 2C HTH_Tnp_1 PF01527.15 CDJ26794.1 - 0.00018 21.4 1.1 0.00098 19.0 0.8 2.4 1 1 0 1 1 1 1 Transposase Bromodomain PF00439.20 CDJ26795.1 - 5.9e-12 45.3 0.0 1.1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Bromodomain EspB PF05802.6 CDJ26796.1 - 0.066 12.1 0.4 0.07 12.0 0.3 1.0 1 0 0 1 1 1 0 Enterobacterial EspB protein BPL_LplA_LipB PF03099.14 CDJ26799.1 - 8.8e-12 45.1 0.2 2e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.12 CDJ26799.1 - 0.027 14.1 0.1 0.068 12.8 0.1 1.6 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Mem_trans PF03547.13 CDJ26800.1 - 0.053 11.8 2.2 0.074 11.3 1.5 1.3 1 0 0 1 1 1 0 Membrane transport protein Draxin PF15550.1 CDJ26800.1 - 0.93 9.0 31.0 3.7 7.1 21.5 2.1 1 0 0 1 1 1 0 Draxin LMBR1 PF04791.11 CDJ26800.1 - 7 5.1 15.9 11 4.4 11.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Ist1 PF03398.9 CDJ26802.1 - 7.6e-28 96.9 0.3 3.1e-27 95.0 0.2 1.9 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway PAT1 PF09770.4 CDJ26802.1 - 1.4 7.1 17.0 1.6 6.8 11.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.8 CDJ26802.1 - 1.5 7.6 11.2 2.1 7.1 7.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF1162 PF06650.7 CDJ26803.1 - 5.3e-06 25.8 0.0 3.1e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1162) DUF570 PF04489.8 CDJ26803.1 - 1 7.6 0.0 1.7 7.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF570) Abhydrolase_3 PF07859.8 CDJ26804.1 - 0.00036 20.1 0.0 0.00069 19.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 CDJ26804.1 - 0.048 12.3 0.0 0.07 11.8 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family Nop52 PF05997.7 CDJ26805.1 - 1.1e-42 145.9 4.8 1.1e-42 145.9 3.3 2.4 2 0 0 2 2 2 1 Nucleolar protein,Nop52 TSA PF03249.8 CDJ26806.1 - 2.8 6.3 5.9 4.2 5.7 4.1 1.2 1 0 0 1 1 1 0 Type specific antigen RRM_1 PF00076.17 CDJ26807.1 - 0.0009 18.8 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDJ26807.1 - 0.0014 18.4 0.1 0.0031 17.3 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDJ26807.1 - 0.097 12.6 0.0 0.16 12.0 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SPATIAL PF15256.1 CDJ26808.1 - 0.056 13.4 1.7 0.087 12.8 1.1 1.2 1 0 0 1 1 1 0 SPATIAL ETRAMP PF09716.5 CDJ26808.1 - 0.34 10.8 0.0 0.34 10.8 0.0 3.0 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Med15 PF09606.5 CDJ26809.1 - 0.00067 17.9 61.1 0.00067 17.9 42.4 2.2 2 1 1 3 3 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDJ26809.1 - 0.038 12.2 42.3 0.053 11.7 29.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CKAP2_C PF15297.1 CDJ26809.1 - 0.049 12.4 17.1 0.078 11.7 11.9 1.3 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus BUD22 PF09073.5 CDJ26809.1 - 0.087 11.8 30.1 0.15 11.0 20.9 1.3 1 0 0 1 1 1 0 BUD22 DUF4045 PF13254.1 CDJ26809.1 - 0.28 10.4 24.9 0.01 15.1 13.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) DUF2457 PF10446.4 CDJ26809.1 - 0.68 8.5 20.6 1.2 7.7 14.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Neur_chan_memb PF02932.11 CDJ26809.1 - 2.3 8.0 16.1 5.3 6.8 11.2 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nop14 PF04147.7 CDJ26809.1 - 2.4 5.9 29.1 3.3 5.5 20.2 1.1 1 0 0 1 1 1 0 Nop14-like family NARP1 PF12569.3 CDJ26809.1 - 3.2 6.3 19.6 5.3 5.6 13.6 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4647 PF15504.1 CDJ26809.1 - 4.6 5.9 24.3 6.9 5.4 16.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Utp14 PF04615.8 CDJ26809.1 - 5.7 4.9 33.1 8.2 4.4 22.9 1.1 1 0 0 1 1 1 0 Utp14 protein Ycf1 PF05758.7 CDJ26809.1 - 7.8 4.0 21.1 10 3.6 14.6 1.1 1 0 0 1 1 1 0 Ycf1 SNARE_assoc PF09335.6 CDJ26810.1 - 1.8e-07 31.3 1.1 1.8e-07 31.3 0.8 3.8 3 1 1 4 4 4 1 SNARE associated Golgi protein DDHD PF02862.12 CDJ26810.1 - 0.073 12.8 2.9 0.11 12.2 0.7 2.0 2 0 0 2 2 2 0 DDHD domain TFIIA PF03153.8 CDJ26810.1 - 0.57 10.0 14.7 2.9 7.6 0.9 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.9 CDJ26810.1 - 2.5 7.7 8.3 0.9 9.2 1.2 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF2572 PF10833.3 CDJ26810.1 - 8.7 5.6 11.4 0.34 10.2 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2572) DUF4367 PF14285.1 CDJ26812.1 - 0.016 14.5 0.4 0.016 14.5 0.3 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4367) BUD22 PF09073.5 CDJ26812.1 - 0.19 10.7 36.8 0.013 14.5 17.4 2.1 2 0 0 2 2 2 0 BUD22 Secretin_N_2 PF07655.8 CDJ26812.1 - 0.43 11.0 18.5 1.1 9.6 12.9 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain COPI_C PF06957.6 CDJ26812.1 - 0.53 8.7 8.4 0.91 7.9 5.8 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF572 PF04502.8 CDJ26812.1 - 1.9 7.6 25.1 0.8 8.8 8.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) PI3K_1B_p101 PF10486.4 CDJ26812.1 - 7.6 3.9 15.9 2.5 5.5 8.5 1.8 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Herpes_pp85 PF04637.7 CDJ26812.1 - 9.1 4.4 8.6 14 3.7 5.9 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SOBP PF15279.1 CDJ26813.1 - 1.7 8.9 7.1 2.1 8.6 4.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein TATR PF03430.8 CDJ26813.1 - 2 6.9 9.2 2.7 6.5 6.4 1.2 1 0 0 1 1 1 0 Trans-activating transcriptional regulator DUF966 PF06136.8 CDJ26813.1 - 2.3 7.5 10.1 3.6 6.8 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Pkinase PF00069.20 CDJ26814.1 - 8.7e-38 129.9 0.0 9.8e-38 129.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDJ26814.1 - 3.4e-16 59.1 0.0 3.9e-16 58.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDJ26814.1 - 2.7e-08 33.1 0.0 3.5e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CDJ26814.1 - 0.0021 17.8 0.0 0.003 17.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CDJ26814.1 - 0.0023 17.0 0.0 0.003 16.6 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 CDJ26814.1 - 0.019 14.3 0.0 0.024 13.9 0.0 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF3116 PF11313.3 CDJ26814.1 - 0.05 13.2 0.0 6 6.5 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3116) EcKinase PF02958.15 CDJ26814.1 - 0.05 12.7 0.1 0.064 12.3 0.1 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase DUF2890 PF11081.3 CDJ26816.1 - 0.4 10.7 11.0 0.51 10.3 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) XAP5 PF04921.9 CDJ26816.1 - 0.5 9.8 6.9 0.57 9.7 4.8 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator RuBisCO_large_N PF02788.11 CDJ26816.1 - 0.67 9.6 3.2 0.78 9.4 2.2 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain BNIP2 PF12496.3 CDJ26816.1 - 1.3 9.1 4.6 1.7 8.8 3.2 1.1 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CDC45 PF02724.9 CDJ26816.1 - 1.6 6.6 9.5 1.7 6.5 6.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Spore_coat_CotO PF14153.1 CDJ26816.1 - 1.9 7.8 5.9 2.1 7.7 4.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Daxx PF03344.10 CDJ26816.1 - 2.3 6.5 12.5 2.6 6.4 8.6 1.0 1 0 0 1 1 1 0 Daxx Family SpoIIIAH PF12685.2 CDJ26816.1 - 2.7 7.4 10.5 2.8 7.3 7.3 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein Nop14 PF04147.7 CDJ26816.1 - 3.8 5.3 12.5 4 5.2 8.7 1.0 1 0 0 1 1 1 0 Nop14-like family DUF1510 PF07423.6 CDJ26816.1 - 3.9 6.7 11.0 4.3 6.6 7.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RLL PF10036.4 CDJ26816.1 - 4.5 6.6 6.5 5.3 6.3 4.5 1.0 1 0 0 1 1 1 0 Putative carnitine deficiency-associated protein Pox_RNA_Pol_19 PF05320.7 CDJ26816.1 - 5.7 6.6 6.7 6.7 6.4 4.6 1.1 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Sigma70_ner PF04546.8 CDJ26816.1 - 5.7 6.4 11.7 7.5 6.1 8.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Paf1 PF03985.8 CDJ26816.1 - 8.5 4.9 8.7 8.6 4.9 6.0 1.0 1 0 0 1 1 1 0 Paf1 Cytochrome-c551 PF10643.4 CDJ26816.1 - 8.8 5.5 6.7 10 5.3 4.6 1.1 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Sporozoite_P67 PF05642.6 CDJ26816.1 - 9 4.0 8.8 10 3.8 6.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.1 CDJ26819.1 - 0.072 13.3 1.4 2.3 8.6 0.0 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIA PF03153.8 CDJ26819.1 - 0.5 10.2 10.4 0.61 9.9 7.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM51 PF15345.1 CDJ26819.1 - 0.98 9.0 7.5 0.48 10.0 3.8 1.5 1 1 0 1 1 1 0 Transmembrane protein 51 Med17 PF10156.4 CDJ26819.1 - 3.8 5.6 6.0 0.54 8.4 0.2 1.9 2 0 0 2 2 2 0 Subunit 17 of Mediator complex DUF2217 PF10265.4 CDJ26820.1 - 4.6 5.8 4.4 8.4 5.0 3.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) PI-PLC-X PF00388.14 CDJ26821.1 - 3.6e-09 36.1 0.0 7.8e-09 35.0 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain RskA PF10099.4 CDJ26821.1 - 0.071 12.8 8.8 0.096 12.4 6.1 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Med3 PF11593.3 CDJ26821.1 - 2.8 7.1 9.1 3.4 6.8 6.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DEC-1_N PF04625.8 CDJ26821.1 - 7.8 5.0 11.8 12 4.4 8.2 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Arm PF00514.18 CDJ26822.1 - 0.088 12.6 0.7 5.9 6.8 0.2 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Med15 PF09606.5 CDJ26823.1 - 9.9e-12 43.8 137.0 7.6e-09 34.3 68.0 2.1 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDJ26823.1 - 0.00047 18.5 71.2 0.00047 18.5 49.3 2.5 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 AMP-binding PF00501.23 CDJ26824.1 - 3e-36 124.6 0.0 5.2e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CDJ26824.1 - 0.0062 17.4 0.2 0.012 16.5 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Creatinase_N PF01321.13 CDJ26824.1 - 0.018 15.5 0.1 0.029 14.8 0.1 1.3 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain NYN_YacP PF05991.6 CDJ26824.1 - 0.028 14.1 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 YacP-like NYN domain tRNA_bind_2 PF13725.1 CDJ26825.1 - 2.3e-15 56.5 2.3 4.4e-15 55.6 0.0 2.1 2 0 0 2 2 2 1 Possible tRNA binding domain Glycos_trans_3N PF02885.12 CDJ26825.1 - 0.17 11.4 1.4 4.7 6.8 0.0 2.6 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain PIP5K PF01504.13 CDJ26826.1 - 1.1e-07 31.2 0.3 1.2e-07 31.0 0.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 CDJ26827.1 - 2.8e-46 158.1 2.0 5.8e-46 157.1 1.4 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1192 PF06698.6 CDJ26827.1 - 0.027 14.2 2.3 3.2 7.6 0.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) SecA_SW PF07516.8 CDJ26827.1 - 0.043 13.5 2.7 0.1 12.3 1.9 1.6 1 1 0 1 1 1 0 SecA Wing and Scaffold domain Matrilin_ccoil PF10393.4 CDJ26827.1 - 0.056 12.8 0.5 0.15 11.4 0.3 1.6 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DNA_primase_lrg PF04104.9 CDJ26827.1 - 0.097 11.9 3.2 0.97 8.6 0.3 2.1 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit Mnd1 PF03962.10 CDJ26827.1 - 0.12 12.0 6.0 17 4.9 0.4 2.3 1 1 1 2 2 2 0 Mnd1 family Nbl1_Borealin_N PF10444.4 CDJ26827.1 - 0.14 11.5 2.7 0.74 9.2 0.2 2.5 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal V-ATPase_H_N PF03224.9 CDJ26828.1 - 0.00023 20.3 0.0 0.00023 20.3 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit H DUF2610 PF11020.3 CDJ26828.1 - 0.083 12.6 0.0 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2610) Glyco_transf_20 PF00982.16 CDJ26829.1 - 2e-14 52.9 0.0 2.1e-14 52.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 AAA_18 PF13238.1 CDJ26832.1 - 1.6e-24 86.6 0.0 2.7e-24 85.9 0.0 1.4 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 CDJ26832.1 - 1.6e-15 57.9 0.0 2.4e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDJ26832.1 - 1.4e-06 28.5 0.0 4.3e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDJ26832.1 - 1.7e-06 28.0 0.3 2.9e-05 23.9 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDJ26832.1 - 2.3e-05 24.4 0.3 9.3e-05 22.4 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.5 CDJ26832.1 - 2.7e-05 23.5 0.1 0.0001 21.6 0.0 1.9 2 0 0 2 2 2 1 Chromatin associated protein KTI12 NTPase_1 PF03266.10 CDJ26832.1 - 2.9e-05 23.8 0.0 6.4e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 NTPase AAA_28 PF13521.1 CDJ26832.1 - 4.9e-05 23.3 0.8 0.00013 22.0 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 CDJ26832.1 - 7.2e-05 22.9 0.2 0.00016 21.9 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 CDJ26832.1 - 0.00016 21.5 0.3 0.001 18.9 0.2 2.4 1 1 0 1 1 1 1 Shikimate kinase AAA_14 PF13173.1 CDJ26832.1 - 0.0003 20.6 0.1 0.0018 18.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 CDJ26832.1 - 0.00088 18.8 0.1 0.0072 15.8 0.0 2.0 2 0 0 2 2 2 1 FtsK/SpoIIIE family ADK PF00406.17 CDJ26832.1 - 0.00093 19.0 0.1 0.033 14.0 0.0 2.3 2 1 0 2 2 2 1 Adenylate kinase AAA_10 PF12846.2 CDJ26832.1 - 0.0011 18.4 0.4 0.0053 16.2 0.2 2.2 1 1 0 1 1 1 1 AAA-like domain RNA_helicase PF00910.17 CDJ26832.1 - 0.0012 18.9 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA helicase T2SE PF00437.15 CDJ26832.1 - 0.0024 16.8 0.1 0.0075 15.2 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein Sigma54_activat PF00158.21 CDJ26832.1 - 0.0032 16.9 0.3 0.47 9.9 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.7 CDJ26832.1 - 0.0034 17.0 0.2 0.0094 15.6 0.0 1.7 2 1 0 2 2 2 1 NACHT domain KaiC PF06745.8 CDJ26832.1 - 0.0036 16.4 0.1 0.0074 15.4 0.0 1.5 2 0 0 2 2 2 1 KaiC RuvB_N PF05496.7 CDJ26832.1 - 0.0036 16.3 0.0 0.0061 15.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus MobB PF03205.9 CDJ26832.1 - 0.0047 16.6 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.9 CDJ26832.1 - 0.0093 14.9 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain AAA_5 PF07728.9 CDJ26832.1 - 0.011 15.4 0.0 0.03 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 CDJ26832.1 - 0.012 15.0 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.12 CDJ26832.1 - 0.013 15.0 0.1 0.033 13.7 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.12 CDJ26832.1 - 0.015 14.7 0.0 0.037 13.4 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein ArgK PF03308.11 CDJ26832.1 - 0.017 13.8 0.0 0.031 13.0 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_19 PF13245.1 CDJ26832.1 - 0.017 14.8 0.1 0.036 13.8 0.1 1.7 1 1 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 CDJ26832.1 - 0.018 14.1 0.1 0.091 11.8 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin FDX-ACB PF03147.9 CDJ26832.1 - 0.021 15.0 0.3 0.043 14.0 0.2 1.5 1 0 0 1 1 1 0 Ferredoxin-fold anticodon binding domain AAA_3 PF07726.6 CDJ26832.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 CDJ26832.1 - 0.022 14.4 0.1 0.052 13.2 0.1 1.7 1 1 0 1 1 1 0 Archaeal ATPase AAA_25 PF13481.1 CDJ26832.1 - 0.023 14.0 0.2 0.03 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 CDJ26832.1 - 0.024 14.4 0.1 0.1 12.3 0.1 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Miro PF08477.8 CDJ26832.1 - 0.028 14.9 0.1 0.063 13.7 0.0 1.8 1 1 1 2 2 2 0 Miro-like protein ArsA_ATPase PF02374.10 CDJ26832.1 - 0.035 13.1 1.1 0.18 10.7 0.0 2.0 1 1 1 2 2 2 0 Anion-transporting ATPase DUF2075 PF09848.4 CDJ26832.1 - 0.036 13.0 0.4 0.061 12.2 0.3 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.1 CDJ26832.1 - 0.044 13.3 0.0 0.1 12.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_32 PF13654.1 CDJ26832.1 - 0.052 12.2 0.8 1.5 7.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.12 CDJ26832.1 - 0.059 12.7 0.2 0.43 9.9 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase SRP54 PF00448.17 CDJ26832.1 - 0.063 12.7 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain APS_kinase PF01583.15 CDJ26832.1 - 0.07 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase UPF0079 PF02367.12 CDJ26832.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 LMBR1 PF04791.11 CDJ26835.1 - 0.0049 15.5 0.0 0.0049 15.5 0.0 7.1 6 2 3 9 9 9 2 LMBR1-like membrane protein DRMBL PF07522.9 CDJ26836.1 - 0.078 13.0 0.1 0.2 11.7 0.1 1.8 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Herpes_UL3 PF03369.8 CDJ26836.1 - 0.14 12.1 0.1 0.14 12.1 0.0 3.1 2 1 2 4 4 4 0 Herpesvirus UL3 protein