# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- MMR_HSR1 PF01926.23 CDI76016.1 - 9.6e-09 35.3 0.0 0.00014 21.9 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 CDI76016.1 - 0.01 14.9 0.1 0.017 14.2 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 CDI76016.1 - 0.032 14.6 5.2 2.2 8.6 0.1 3.2 2 1 1 3 3 3 0 AAA ATPase domain DUF2203 PF09969.9 CDI76016.1 - 0.045 14.5 4.4 5.6 7.7 2.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Zip PF02535.22 CDI76016.1 - 0.078 12.2 0.1 0.078 12.2 0.1 2.5 2 1 1 3 3 3 0 ZIP Zinc transporter MobB PF03205.14 CDI76016.1 - 0.085 12.8 0.1 0.085 12.8 0.1 1.8 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 CDI76016.1 - 0.087 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B IRF PF00605.17 CDI76016.1 - 0.12 12.6 3.9 0.42 10.9 0.8 2.3 2 0 0 2 2 2 0 Interferon regulatory factor transcription factor LMBR1 PF04791.16 CDI76016.1 - 0.27 10.1 3.2 4.1 6.2 0.4 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein baeRF_family3 PF18845.1 CDI76016.1 - 0.58 10.4 10.2 0.43 10.8 5.0 2.2 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 ABC_tran PF00005.27 CDI76016.1 - 0.61 10.6 0.0 0.61 10.6 0.0 2.8 2 1 1 3 3 2 0 ABC transporter TFIIA PF03153.13 CDI76016.1 - 1 9.3 27.0 1.1 9.2 16.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI76016.1 - 1.2 9.3 9.8 2.5 8.2 1.3 2.3 2 0 0 2 2 2 0 DDHD domain Peptidase_U57 PF05582.12 CDI76016.1 - 1.7 7.9 5.9 4.9 6.3 3.3 2.0 2 0 0 2 2 2 0 YabG peptidase U57 Spt20 PF12090.8 CDI76016.1 - 3.1 7.3 28.4 0.66 9.5 13.4 2.3 2 0 0 2 2 2 0 Spt20 family Neur_chan_memb PF02932.16 CDI76016.1 - 8.4 6.4 11.1 8.5 6.4 2.4 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4578 PF15147.6 CDI76019.1 - 0.016 16.1 4.7 0.016 16.1 4.7 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4578) DHHC PF01529.20 CDI76021.1 - 0.0018 18.4 6.3 0.0028 17.8 6.3 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase TBP PF00352.21 CDI76023.1 - 2.5e-33 113.9 0.0 4.1e-22 77.9 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) G0-G1_switch_2 PF15103.6 CDI76024.1 - 0.044 14.2 0.0 0.074 13.5 0.0 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 TBPIP PF07106.13 CDI76025.1 - 2.7e-05 24.0 0.5 9.9e-05 22.2 0.1 2.0 1 1 1 2 2 2 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 CDI76025.1 - 0.0013 18.8 0.0 0.0033 17.5 0.0 1.8 2 0 0 2 2 2 1 Leucine zipper with capping helix domain FliD_N PF02465.18 CDI76025.1 - 0.15 12.7 2.8 0.27 12.0 2.8 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Preseq_ALAS PF09029.10 CDI76026.1 - 0.082 13.4 1.3 0.26 11.8 1.3 1.9 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence Etmic-2 PF06670.11 CDI76028.1 - 5.1e-67 226.5 16.3 2.2e-45 155.2 8.1 2.9 1 1 1 2 2 2 2 Microneme protein Etmic-2 Pkinase PF00069.25 CDI76031.1 - 0.012 15.0 0.0 0.056 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76031.1 - 0.053 12.8 0.0 0.08 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase SNF2_N PF00176.23 CDI76033.1 - 2.5e-68 230.4 0.0 3.5e-68 229.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_5 PF14634.6 CDI76033.1 - 5.9e-08 32.6 3.7 1.3e-07 31.4 3.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDI76033.1 - 1.7e-06 27.8 5.1 3.4e-06 26.8 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI76033.1 - 1.9e-06 27.6 5.8 3.8e-06 26.7 5.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI76033.1 - 6.8e-06 26.3 6.0 1.6e-05 25.1 6.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDI76033.1 - 3.6e-05 23.5 7.0 8.7e-05 22.3 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI76033.1 - 0.00013 21.9 3.8 0.00034 20.6 3.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDI76033.1 - 0.0014 18.8 7.6 0.003 17.7 7.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Helicase_C PF00271.31 CDI76033.1 - 0.0046 17.3 0.0 0.17 12.2 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 CDI76033.1 - 0.049 13.5 12.2 0.016 15.1 7.1 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-MIZ PF02891.20 CDI76033.1 - 0.06 13.1 3.1 0.16 11.7 3.1 1.8 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_4 PF14570.6 CDI76033.1 - 0.089 12.6 1.9 0.22 11.3 1.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 CDI76033.1 - 0.33 11.0 3.2 0.69 10.0 3.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Peptidase_C48 PF02902.19 CDI76035.1 - 3.7e-20 72.7 0.0 9.9e-20 71.3 0.0 1.7 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Flexi_CP PF00286.20 CDI76036.1 - 0.035 14.0 0.1 0.073 13.0 0.1 1.5 1 0 0 1 1 1 0 Viral coat protein Ank_2 PF12796.7 CDI76038.1 - 3.5e-05 24.3 0.0 5.7e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI76038.1 - 0.00025 21.5 0.0 0.00048 20.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI76038.1 - 0.00042 20.6 0.0 0.18 12.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CDI76038.1 - 0.00051 20.4 0.0 0.44 11.1 0.0 2.6 2 1 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CDI76038.1 - 0.0012 19.2 0.0 0.15 12.7 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeat Trypan_PARP PF05887.11 CDI76038.1 - 0.065 13.2 6.0 0.1 12.6 6.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_M24 PF00557.24 CDI76039.1 - 2.3e-32 112.4 0.0 4.2e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CDI76039.1 - 5e-14 52.1 0.0 9e-14 51.3 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain FBPase PF00316.20 CDI76040.1 - 1.6e-31 109.3 0.0 2.4e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain SF-assemblin PF06705.11 CDI76042.1 - 1.5e-36 126.0 19.3 1.8e-36 125.8 19.3 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin DUF713 PF05218.14 CDI76042.1 - 0.06 13.1 6.6 0.1 12.3 1.9 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF713) Baculo_PEP_C PF04513.12 CDI76042.1 - 0.12 12.4 11.6 0.095 12.7 0.6 3.6 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rab_bind PF16704.5 CDI76042.1 - 0.17 12.0 3.5 0.59 10.2 0.9 2.9 1 1 2 3 3 3 0 Rab binding domain YabA PF06156.13 CDI76042.1 - 0.34 11.6 0.2 0.34 11.6 0.2 3.4 1 1 1 3 3 3 0 Initiation control protein YabA Peptidase_C50 PF03568.17 CDI76043.1 - 9.5e-06 25.0 0.0 1.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 DoxX PF07681.12 CDI76044.1 - 0.3 11.7 1.3 1.3 9.7 0.2 2.5 3 0 0 3 3 3 0 DoxX Peptidase_S8 PF00082.22 CDI76046.1 - 1.8e-43 148.9 0.1 3e-43 148.2 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Cu-binding_MopE PF11617.8 CDI76046.1 - 0.11 12.7 3.1 0.25 11.6 3.1 1.6 1 0 0 1 1 1 0 Putative metal-binding motif V-SNARE_C PF12352.8 CDI76047.1 - 9.1e-13 48.3 0.1 9.1e-13 48.3 0.1 1.7 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CDI76047.1 - 0.0024 17.7 0.0 0.0054 16.6 0.0 1.5 1 0 0 1 1 1 1 Sec20 AA_permease_2 PF13520.6 CDI76047.1 - 0.047 12.5 0.2 0.065 12.0 0.2 1.1 1 0 0 1 1 1 0 Amino acid permease RRM_1 PF00076.22 CDI76049.1 - 1.2e-09 37.8 0.0 2.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI76049.1 - 0.0041 17.1 0.0 0.0077 16.2 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif CCSAP PF15748.5 CDI76050.1 - 5.1 7.2 27.7 6.5 6.8 27.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DnaJ_C PF01556.18 CDI76051.1 - 5.7e-34 117.3 0.1 8.1e-34 116.8 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDI76051.1 - 2.5e-23 82.0 1.9 4.3e-23 81.2 1.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDI76051.1 - 9.9e-13 48.2 16.6 9.9e-13 48.2 16.6 2.0 2 0 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 CDI76051.1 - 0.061 13.3 9.8 1.7 8.6 2.5 2.9 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CDI76051.1 - 0.42 10.6 11.0 1.8 8.6 0.5 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Tnp_zf-ribbon_2 PF13842.6 CDI76051.1 - 0.48 11.3 11.1 1.1 10.1 0.1 3.0 2 1 1 3 3 3 0 DDE_Tnp_1-like zinc-ribbon SPX PF03105.19 CDI76053.1 - 1.5e-05 25.1 2.3 1.5e-05 25.1 2.3 15.3 7 3 2 10 10 10 1 SPX domain Apt1 PF10351.9 CDI76053.1 - 0.087 11.7 0.0 0.087 11.7 0.0 15.2 12 5 0 12 12 12 0 Golgi-body localisation protein domain Mlh1_C PF16413.5 CDI76054.1 - 3.7e-53 180.6 1.7 3.7e-53 180.6 1.7 3.2 3 1 0 3 3 3 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CDI76054.1 - 4.5e-27 94.1 0.0 9.8e-27 93.0 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CDI76054.1 - 7.7e-10 38.7 0.0 3.4e-09 36.6 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDI76054.1 - 0.0055 17.2 0.0 0.016 15.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Collectrin PF16959.5 CDI76054.1 - 4.7 7.0 5.9 11 5.8 2.3 2.4 2 0 0 2 2 2 0 Renal amino acid transporter Proteasome PF00227.26 CDI76055.1 - 9.3e-25 87.2 9.4 3.2e-13 49.6 0.0 3.2 2 1 1 3 3 3 2 Proteasome subunit DUF5336 PF17270.2 CDI76055.1 - 0.13 11.8 0.1 0.13 11.8 0.1 3.7 3 1 0 3 3 3 0 Family of unknown function (DUF5336) LicD PF04991.13 CDI76055.1 - 0.48 10.5 6.9 0.93 9.6 6.9 1.5 1 0 0 1 1 1 0 LicD family GREB1 PF15782.5 CDI76055.1 - 0.54 7.3 33.2 0.9 6.6 33.2 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MDM10 PF12519.8 CDI76055.1 - 9.4 5.0 22.2 24 3.6 19.0 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 FAP206 PF12018.8 CDI76056.1 - 7e-12 45.4 2.5 7e-12 45.4 2.5 2.7 2 1 0 2 2 2 1 Domain of unknown function Leucyl-specific PF14795.6 CDI76056.1 - 0.054 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Leucine-tRNA synthetase-specific domain PhoD PF09423.10 CDI76057.1 - 3e-05 23.2 2.2 0.00035 19.7 1.4 2.2 1 1 0 2 2 2 1 PhoD-like phosphatase DUF4834 PF16118.5 CDI76057.1 - 0.0016 19.4 1.7 1.9 9.5 2.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI76057.1 - 0.0072 16.4 5.2 0.0072 16.4 5.2 2.0 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI76057.1 - 0.011 14.5 10.4 0.017 13.9 10.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal KASH PF10541.9 CDI76057.1 - 5.1 7.4 16.5 17 5.8 0.1 2.6 2 0 0 2 2 2 0 Nuclear envelope localisation domain SUIM_assoc PF16619.5 CDI76057.1 - 7.8 6.6 20.3 15 5.8 16.2 2.9 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Utp14 PF04615.13 CDI76058.1 - 0.23 10.0 27.3 0.3 9.6 27.3 1.1 1 0 0 1 1 1 0 Utp14 protein BAT PF15915.5 CDI76058.1 - 0.99 9.3 9.2 5.2 6.9 0.9 2.2 2 0 0 2 2 2 0 GAF and HTH_10 associated domain TFIIA PF03153.13 CDI76059.1 - 6.7 6.6 16.3 8.7 6.2 16.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Coatomer_WDAD PF04053.14 CDI76060.1 - 1.2e-75 255.3 0.0 8.9e-44 150.2 0.8 3.3 1 1 2 3 3 3 3 Coatomer WD associated region WD40 PF00400.32 CDI76060.1 - 5e-16 58.8 10.4 0.00018 22.2 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat PAT1 PF09770.9 CDI76060.1 - 0.63 8.2 35.0 0.93 7.7 35.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TAP42 PF04177.12 CDI76061.1 - 1e-31 110.3 2.5 1.2e-19 70.6 0.1 2.1 2 0 0 2 2 2 2 TAP42-like family EST1 PF10374.9 CDI76061.1 - 0.15 12.7 1.0 0.3 11.7 1.0 1.5 1 0 0 1 1 1 0 Telomerase activating protein Est1 DUF2722 PF10846.8 CDI76063.1 - 0.00018 20.6 16.0 0.00018 20.6 16.0 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) RPA43_OB PF17875.1 CDI76063.1 - 0.0028 18.3 1.5 0.0028 18.3 1.5 2.1 3 0 0 3 3 1 1 RPA43 OB domain in RNA Pol I SpoIIP PF07454.11 CDI76063.1 - 0.027 13.9 3.8 0.06 12.8 3.8 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI76063.1 - 0.088 12.6 1.1 0.19 11.4 1.1 1.6 1 0 0 1 1 1 0 Connexin CLN3 PF02487.17 CDI76063.1 - 0.15 11.0 0.2 0.29 10.1 0.2 1.6 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 CDI76063.1 - 0.21 11.4 4.1 0.47 10.2 4.1 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 CDI76063.1 - 0.26 10.9 1.9 0.71 9.5 1.9 1.7 1 0 0 1 1 1 0 FAM176 family Plasmodium_Vir PF05795.11 CDI76063.1 - 0.3 10.5 1.6 0.44 9.9 1.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 CDI76063.1 - 0.35 9.7 6.8 0.65 8.8 6.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4746 PF15928.5 CDI76063.1 - 0.5 9.7 3.1 0.84 9.0 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) BatD PF13584.6 CDI76063.1 - 1.4 7.6 12.6 0.08 11.7 5.3 2.3 2 0 0 2 2 2 0 Oxygen tolerance SR-25 PF10500.9 CDI76063.1 - 1.7 8.2 24.7 2.3 7.8 5.3 3.0 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI76063.1 - 1.7 8.6 56.3 3.3 7.6 3.1 3.1 1 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF4207 PF13904.6 CDI76063.1 - 1.8 8.2 31.6 0.056 13.1 12.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) RIC3 PF15361.6 CDI76063.1 - 3 8.2 12.2 0.27 11.6 6.9 2.0 2 1 0 2 2 1 0 Resistance to inhibitors of cholinesterase homologue 3 AIF_C PF14721.6 CDI76063.1 - 3.8 7.9 6.9 0.36 11.2 1.4 2.1 2 0 0 2 2 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term WBP-1 PF11669.8 CDI76063.1 - 4.2 8.0 14.6 0.66 10.6 4.5 3.0 3 0 0 3 3 3 0 WW domain-binding protein 1 NEMP PF10225.9 CDI76063.1 - 4.4 6.9 6.3 1.1 8.9 2.6 1.8 2 0 0 2 2 2 0 NEMP family Paf1 PF03985.13 CDI76063.1 - 5.4 5.9 12.6 12 4.8 12.6 1.5 1 0 0 1 1 1 0 Paf1 PAT1 PF09770.9 CDI76063.1 - 7.4 4.7 19.3 0.013 13.8 7.3 2.3 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 AP2 PF00847.20 CDI76065.1 - 1.1e-11 44.7 1.2 3.4e-10 40.0 1.2 3.9 1 0 0 1 1 1 1 AP2 domain DOT1 PF08123.13 CDI76068.1 - 0.00024 20.7 0.1 0.00047 19.7 0.1 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 PrmA PF06325.13 CDI76068.1 - 0.0034 16.8 0.7 0.0082 15.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CRAL_TRIO PF00650.20 CDI76069.1 - 3.7e-05 23.5 0.1 0.0002 21.1 0.0 1.9 1 1 1 2 2 2 1 CRAL/TRIO domain RIBIOP_C PF04950.12 CDI76070.1 - 6.9e-70 235.8 0.0 3.1e-69 233.6 0.0 1.9 1 1 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CDI76070.1 - 2e-07 31.0 0.0 6.4e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 AARP2CN (NUC121) domain HemY_N PF07219.13 CDI76073.1 - 0.43 10.8 5.8 0.95 9.7 0.8 2.9 3 0 0 3 3 3 0 HemY protein N-terminus cEGF PF12662.7 CDI76075.1 - 5.1e-07 29.5 4.4 1.7e-06 27.8 4.4 2.0 1 0 0 1 1 1 1 Complement Clr-like EGF-like Peptidase_C11 PF03415.14 CDI76075.1 - 2.4e-06 27.2 0.0 0.00016 21.2 0.0 2.9 3 0 0 3 3 3 1 Clostripain family Notch PF00066.17 CDI76075.1 - 8.7e-05 22.9 2.5 8.7e-05 22.9 2.5 2.5 3 0 0 3 3 3 1 LNR domain MSP PF01716.18 CDI76075.1 - 0.15 11.2 0.5 16 4.6 0.0 2.4 2 0 0 2 2 2 0 Manganese-stabilising protein / photosystem II polypeptide DUF241 PF03087.14 CDI76076.1 - 0.092 12.6 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function RNase_Zc3h12a PF11977.8 CDI76078.1 - 3.6e-05 23.6 0.0 5.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain T6SS_TssG PF06996.11 CDI76078.1 - 0.097 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion, TssG CBM_20 PF00686.19 CDI76079.1 - 5.8e-13 48.6 0.0 1.7e-09 37.4 0.0 2.5 2 0 0 2 2 2 2 Starch binding domain Sec7_N PF12783.7 CDI76079.1 - 0.029 14.3 0.5 0.24 11.3 0.4 2.3 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Gcd10p PF04189.13 CDI76080.1 - 6.1e-17 61.7 0.0 1.1e-16 60.8 0.0 1.5 1 1 0 1 1 1 1 Gcd10p family SurA_N_3 PF13624.6 CDI76080.1 - 0.019 14.7 1.3 0.26 11.1 0.0 2.2 2 0 0 2 2 2 0 SurA N-terminal domain ADK PF00406.22 CDI76081.1 - 1.6e-14 54.3 0.8 3.9e-11 43.3 0.8 3.0 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDI76081.1 - 6.1e-11 42.9 0.0 8.9e-08 32.7 0.0 2.1 1 1 1 2 2 2 2 AAA domain AAA_33 PF13671.6 CDI76081.1 - 7.3e-06 26.2 0.1 1.5e-05 25.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDI76081.1 - 2.4e-05 24.9 0.0 5.6e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 CDI76081.1 - 0.00012 21.7 1.2 0.00018 21.1 0.0 1.8 1 1 1 2 2 2 1 Chromatin associated protein KTI12 Cytidylate_kin PF02224.18 CDI76081.1 - 0.00048 19.9 0.1 0.0007 19.4 0.1 1.3 1 1 0 1 1 1 1 Cytidylate kinase Mg_chelatase PF01078.21 CDI76081.1 - 0.00085 18.8 0.1 0.0016 17.9 0.0 1.5 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CDI76081.1 - 0.0015 18.9 0.5 0.0023 18.4 0.5 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CDI76081.1 - 0.0019 18.5 1.0 0.012 15.8 1.0 1.9 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDI76081.1 - 0.036 13.3 0.0 0.066 12.5 0.0 1.4 1 1 0 1 1 1 0 Zeta toxin DUF2924 PF11149.8 CDI76081.1 - 0.059 13.7 0.0 0.095 13.1 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2924) CPT PF07931.12 CDI76081.1 - 0.097 12.5 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TFIIA PF03153.13 CDI76081.1 - 0.12 12.3 5.1 0.14 12.1 5.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI76081.1 - 2.5 8.3 11.8 3.3 7.8 11.5 1.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Topoisom_I_N PF02919.15 CDI76083.1 - 7e-31 107.4 0.0 3.5e-30 105.1 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Peptidase_S64 PF08192.11 CDI76083.1 - 0.62 8.5 9.2 0.78 8.2 9.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 AF-4 PF05110.13 CDI76083.1 - 1.8 6.6 23.2 2.2 6.2 23.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Apt1 PF10351.9 CDI76083.1 - 2.3 6.9 8.4 2.8 6.7 8.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF755 PF05501.11 CDI76083.1 - 3.4 7.9 15.0 7.4 6.9 15.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) PI3K_1B_p101 PF10486.9 CDI76083.1 - 3.6 5.2 7.3 4.8 4.8 7.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF966 PF06136.13 CDI76083.1 - 4.6 6.8 14.8 8.2 6.0 14.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TMEM65 PF10507.9 CDI76084.1 - 1.1e-11 44.6 0.1 1.1e-11 44.6 0.1 3.2 3 1 1 4 4 4 1 Transmembrane protein 65 EF-hand_5 PF13202.6 CDI76084.1 - 7.8e-06 25.1 0.0 1.6e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDI76084.1 - 5.5e-05 23.5 0.0 0.00011 22.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CDI76084.1 - 0.00099 18.5 0.0 0.0025 17.2 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDI76084.1 - 0.0032 17.3 0.0 0.0096 15.8 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain Usp PF00582.26 CDI76084.1 - 8.8 6.8 7.7 8.5 6.9 0.2 3.0 3 0 0 3 3 3 0 Universal stress protein family DUF3395 PF11875.8 CDI76085.1 - 7.7e-21 74.6 4.8 1.9e-18 66.8 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF3395) DnaJ PF00226.31 CDI76085.1 - 4.9e-16 58.6 0.0 9.7e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1682 PF07946.14 CDI76085.1 - 0.03 13.5 2.5 0.044 13.0 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Myotub-related PF06602.14 CDI76085.1 - 0.062 12.2 0.1 0.078 11.9 0.1 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain EF-G-binding_N PF07299.11 CDI76085.1 - 0.11 13.0 3.2 0.24 11.9 3.2 1.5 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal U3_assoc_6 PF08640.11 CDI76086.1 - 9e-11 41.7 3.5 9e-11 41.7 3.5 2.8 2 1 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 SR-25 PF10500.9 CDI76086.1 - 0.0026 17.4 2.5 0.0026 17.4 2.5 9.9 8 2 1 9 9 9 6 Nuclear RNA-splicing-associated protein BUD22 PF09073.10 CDI76087.1 - 0.3 10.4 42.0 0.0084 15.5 33.9 2.0 2 0 0 2 2 2 0 BUD22 GRAS PF03514.14 CDI76087.1 - 1.5 7.6 6.4 0.33 9.8 3.1 1.5 2 0 0 2 2 2 0 GRAS domain family Cytomega_UL84 PF06284.11 CDI76087.1 - 2.3 6.6 7.4 3.2 6.1 7.4 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein GREB1 PF15782.5 CDI76087.1 - 4.6 4.2 14.2 5.1 4.1 14.2 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cwf_Cwc_15 PF04889.12 CDI76087.1 - 4.7 6.9 43.9 0.11 12.2 36.3 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 CDI76089.1 - 0.0013 18.4 7.9 0.0034 17.0 7.9 1.8 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Melibiase_C PF17801.1 CDI76089.1 - 0.023 14.8 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 Alpha galactosidase C-terminal beta sandwich domain GREB1 PF15782.5 CDI76089.1 - 0.56 7.3 4.5 0.78 6.8 4.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI76089.1 - 0.59 8.6 7.6 1.1 7.7 7.6 1.3 1 0 0 1 1 1 0 Macoilin family KAR9 PF08580.10 CDI76089.1 - 1.7 7.1 7.4 2.3 6.6 7.4 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 AF-4 PF05110.13 CDI76089.1 - 3.2 5.7 25.7 5.8 4.9 25.7 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ecl1 PF12855.7 CDI76089.1 - 3.7 8.7 22.7 13 6.9 22.7 1.9 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins SOG2 PF10428.9 CDI76089.1 - 9.4 5.3 14.3 17 4.5 14.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein FAD_binding_2 PF00890.24 CDI76092.1 - 2.1e-53 181.9 9.4 9.1e-27 94.2 0.1 3.3 1 1 2 3 3 3 3 FAD binding domain Succ_DH_flav_C PF02910.20 CDI76092.1 - 3.6e-24 85.2 1.8 9e-24 83.9 1.8 1.7 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CDI76092.1 - 0.0007 18.9 0.1 0.0007 18.9 0.1 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDI76092.1 - 0.0023 17.3 0.3 0.004 16.4 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CDI76092.1 - 0.0054 16.0 0.1 0.01 15.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 CDI76092.1 - 0.019 14.1 2.1 0.019 14.1 2.1 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A RskA PF10099.9 CDI76092.1 - 4.6 7.5 15.3 1.3 9.2 6.4 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DEAD PF00270.29 CDI76095.1 - 3.2e-13 49.8 0.8 4.9e-13 49.2 0.8 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ATG16 PF08614.11 CDI76097.1 - 0.00023 21.4 9.2 0.00023 21.4 9.2 3.5 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) Pox_A_type_inc PF04508.12 CDI76097.1 - 0.00032 20.4 0.8 0.003 17.3 0.2 3.2 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat ZapB PF06005.12 CDI76097.1 - 0.0092 16.4 12.0 0.0092 16.4 12.0 6.9 3 3 2 5 5 5 1 Cell division protein ZapB GAS PF13851.6 CDI76097.1 - 7.7 5.8 63.0 6.8 6.0 24.4 4.1 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Ribosomal_L36e PF01158.18 CDI76099.1 - 1.1e-37 128.2 6.3 1.2e-37 128.0 6.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Bystin PF05291.11 CDI76100.1 - 2.1e-112 375.1 0.5 2.9e-112 374.7 0.5 1.1 1 0 0 1 1 1 1 Bystin YL1 PF05764.13 CDI76100.1 - 0.028 14.6 0.7 0.028 14.6 0.7 1.7 2 0 0 2 2 2 0 YL1 nuclear protein Prothymosin PF03247.14 CDI76100.1 - 0.38 11.2 11.6 0.91 10.0 11.6 1.6 1 0 0 1 1 1 0 Prothymosin/parathymosin family Folate_rec PF03024.14 CDI76101.1 - 0.00047 20.1 0.2 0.00062 19.7 0.2 1.2 1 0 0 1 1 1 1 Folate receptor family Miga PF10265.9 CDI76101.1 - 0.12 11.3 0.2 0.12 11.4 0.2 1.1 1 0 0 1 1 1 0 Mitoguardin DUF2452 PF10504.9 CDI76101.1 - 0.13 11.7 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) Peptidase_C1 PF00112.23 CDI76103.1 - 5.3e-50 170.5 0.5 8e-50 169.9 0.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 CDI76103.1 - 0.012 15.4 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 CDI76103.1 - 0.44 9.3 1.8 4.8 5.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase C1-like family DEAD PF00270.29 CDI76104.1 - 5.7e-13 49.0 0.0 9.9e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI76104.1 - 3.4e-07 30.6 0.0 1.9e-06 28.2 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_7 PF12775.7 CDI76104.1 - 0.18 11.3 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 CDI76104.1 - 0.19 10.8 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AF-4 PF05110.13 CDI76104.1 - 2.5 6.1 7.1 4 5.4 7.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 CDI76104.1 - 8.7 5.9 10.7 15 5.1 10.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TTL PF03133.15 CDI76105.1 - 3.8e-18 65.6 0.0 1e-17 64.2 0.0 1.7 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 CDI76105.1 - 0.00018 20.9 0.0 0.00039 19.7 0.0 1.5 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 CDI76105.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Mitofilin PF09731.9 CDI76106.1 - 2.2 7.0 51.0 2.7 6.7 51.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein THRAP3_BCLAF1 PF15440.6 CDI76106.1 - 6.4 5.7 47.6 6.9 5.6 47.6 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Nop14 PF04147.12 CDI76106.1 - 8.5 4.4 54.2 11 4.0 54.2 1.1 1 0 0 1 1 1 0 Nop14-like family Conotoxin PF02950.17 CDI76107.1 - 0.31 12.1 1.0 1.3e+02 3.7 0.0 4.2 3 0 0 3 3 3 0 Conotoxin SPX PF03105.19 CDI76107.1 - 7.8 6.3 20.9 3.7e+03 -2.5 20.9 2.7 1 1 0 1 1 1 0 SPX domain Sugar_tr PF00083.24 CDI76108.1 - 1.1e-15 57.5 31.8 3e-10 39.6 10.7 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDI76108.1 - 7.9e-09 34.9 53.3 8.3e-09 34.8 21.0 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily NdhL PF10716.9 CDI76108.1 - 0.094 12.7 1.5 2 8.4 1.1 2.6 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit MutS_V PF00488.21 CDI76109.1 - 6e-08 32.9 7.2 0.0086 16.1 0.0 4.2 4 1 0 4 4 4 3 MutS domain V AAA_29 PF13555.6 CDI76109.1 - 0.0049 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDI76109.1 - 0.16 12.4 0.0 0.16 12.4 0.0 4.5 4 1 0 4 4 4 0 AAA domain Proteasome PF00227.26 CDI76113.1 - 2.7e-34 118.3 0.0 4.3e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDI76113.1 - 1.4e-13 50.3 0.1 3e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 CDI76113.1 - 0.055 13.0 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 PQQ-like domain Med6 PF04934.14 CDI76117.1 - 4.4e-09 36.2 2.4 1.1e-08 34.9 0.0 2.6 2 1 0 2 2 2 1 MED6 mediator sub complex component PilP PF04351.13 CDI76117.1 - 0.0053 16.7 0.1 0.0053 16.7 0.1 2.4 2 0 0 2 2 2 1 Pilus assembly protein, PilP DUF3097 PF11296.8 CDI76117.1 - 0.015 14.5 1.2 0.03 13.6 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) FAM60A PF15396.6 CDI76117.1 - 0.043 13.8 7.2 0.056 13.4 4.9 2.0 2 0 0 2 2 2 0 Protein Family FAM60A NPR3 PF03666.13 CDI76117.1 - 0.088 11.6 8.9 0.14 10.9 7.7 1.8 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SPX PF03105.19 CDI76117.1 - 0.15 11.9 13.1 0.34 10.8 12.9 1.5 1 1 0 1 1 1 0 SPX domain Plasmodium_Vir PF05795.11 CDI76117.1 - 0.31 10.4 8.6 0.12 11.8 5.6 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF4718 PF15842.5 CDI76117.1 - 0.33 10.7 10.2 0.65 9.8 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) TFIIA PF03153.13 CDI76117.1 - 0.39 10.7 36.1 1.7 8.6 4.2 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI76117.1 - 0.47 10.0 23.2 0.044 13.4 18.7 1.5 2 0 0 2 2 1 0 Nuclear RNA-splicing-associated protein EPL1 PF10513.9 CDI76117.1 - 0.48 10.8 14.1 1.6 9.1 9.8 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like MPM1 PF17234.2 CDI76117.1 - 0.8 9.9 15.0 0.77 10.0 11.2 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 FAM176 PF14851.6 CDI76117.1 - 0.82 9.3 6.3 1.1 8.9 4.5 2.1 2 0 0 2 2 2 0 FAM176 family DUF1645 PF07816.11 CDI76117.1 - 1 9.9 16.9 0.82 10.2 13.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Pkinase_fungal PF17667.1 CDI76117.1 - 1.1 8.0 9.2 1.8 7.2 9.2 1.3 1 0 0 1 1 1 0 Fungal protein kinase RAP1 PF07218.11 CDI76117.1 - 1.1 7.4 4.6 1.5 7.0 4.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Clr2 PF10383.9 CDI76117.1 - 1.7 9.4 7.0 1.8 9.3 4.4 2.2 2 0 0 2 2 2 0 Transcription-silencing protein Clr2 XAP5 PF04921.14 CDI76117.1 - 3.2 7.5 15.3 3.9 7.2 13.4 1.8 2 0 0 2 2 2 0 XAP5, circadian clock regulator Suf PF05843.14 CDI76117.1 - 3.2 7.6 22.9 5.1 7.0 16.7 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Cwf_Cwc_15 PF04889.12 CDI76117.1 - 3.5 7.3 19.0 1 9.0 14.6 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Dicty_REP PF05086.12 CDI76117.1 - 3.6 5.4 6.6 5.1 4.9 6.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF755 PF05501.11 CDI76117.1 - 3.7 7.9 36.2 0.14 12.4 28.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Apt1 PF10351.9 CDI76117.1 - 3.9 6.2 16.6 6.5 5.5 16.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ctr PF04145.15 CDI76117.1 - 4.1 8.0 6.6 9.5 6.8 5.0 2.2 2 0 0 2 2 2 0 Ctr copper transporter family LAP1C PF05609.12 CDI76117.1 - 5.6 5.9 18.7 2.4 7.1 15.4 1.8 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) CDK2AP PF09806.9 CDI76117.1 - 7.4 6.6 37.9 0.029 14.4 18.2 3.1 3 0 0 3 3 2 0 Cyclin-dependent kinase 2-associated protein GREB1 PF15782.5 CDI76117.1 - 7.8 3.5 16.1 12 2.8 16.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Mem_trans PF03547.18 CDI76117.1 - 8 4.7 5.5 11 4.3 5.5 1.2 1 0 0 1 1 1 0 Membrane transport protein Shadoo PF14999.6 CDI76120.1 - 0.017 15.2 0.8 0.017 15.2 0.8 2.1 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Ribosomal_60s PF00428.19 CDI76120.1 - 0.049 14.2 24.6 0.094 13.3 5.4 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Glt_symporter PF03616.14 CDI76120.1 - 0.059 12.0 0.7 0.081 11.6 0.7 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Ldi PF18566.1 CDI76120.1 - 0.16 11.5 3.5 0.17 11.3 3.5 1.1 1 0 0 1 1 1 0 Linalool dehydratase/isomerase MMR1 PF08505.10 CDI76120.1 - 0.17 12.2 15.3 0.2 11.9 15.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4179 PF13786.6 CDI76120.1 - 0.5 10.9 7.0 1.1 9.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Trp_oprn_chp PF09534.10 CDI76120.1 - 1.3 8.8 23.2 3.2 7.5 6.4 2.0 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pex14_N PF04695.13 CDI76120.1 - 2.5 8.7 30.5 0.62 10.7 20.8 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF382 PF04037.13 CDI76121.1 - 1.6e-50 170.5 0.4 1.6e-50 170.5 0.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 CDI76121.1 - 0.017 15.0 0.3 0.042 13.7 0.3 1.6 1 0 0 1 1 1 0 PSP Anophelin PF10731.9 CDI76121.1 - 0.45 10.4 4.0 0.68 9.8 2.4 2.2 1 1 0 1 1 1 0 Thrombin inhibitor from mosquito DUF5423 PF17461.2 CDI76121.1 - 0.76 8.6 5.8 0.24 10.2 1.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5423) TFIIA PF03153.13 CDI76121.1 - 1.1 9.2 37.7 0.076 13.0 24.2 2.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit COesterase PF00135.28 CDI76121.1 - 3.7 6.3 10.3 0.053 12.4 2.7 1.6 2 0 0 2 2 2 0 Carboxylesterase family A1_Propeptide PF07966.12 CDI76121.1 - 6.3 6.8 7.1 2.6 8.0 3.2 2.3 2 0 0 2 2 2 0 A1 Propeptide Uteroglobin PF01099.17 CDI76122.1 - 0.0095 16.3 3.9 5.2 7.5 0.3 3.6 2 0 0 2 2 2 2 Uteroglobin family TPR_1 PF00515.28 CDI76123.1 - 2.6e-09 36.5 0.9 0.0075 16.1 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDI76123.1 - 1e-06 28.3 0.5 0.093 12.4 0.0 3.5 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.17 CDI76123.1 - 2.6e-06 27.1 1.2 0.024 14.7 0.0 4.5 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF2681 PF10883.8 CDI76123.1 - 0.0027 18.1 7.1 0.0027 18.1 7.1 7.2 4 2 0 4 4 4 1 Protein of unknown function (DUF2681) Hydrolase_6 PF13344.6 CDI76124.1 - 4.6e-30 103.7 2.0 6.8e-29 100.0 0.6 2.9 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDI76124.1 - 1.1e-08 35.0 0.1 1.1e-08 35.0 0.1 3.2 3 2 0 3 3 3 1 HAD-hyrolase-like Isy1 PF06246.12 CDI76124.1 - 0.0024 17.5 3.0 0.0035 16.9 3.0 1.2 1 0 0 1 1 1 1 Isy1-like splicing family Roughex PF06020.11 CDI76124.1 - 0.009 15.1 0.2 0.014 14.5 0.2 1.2 1 0 0 1 1 1 1 Drosophila roughex protein EcoRI_methylase PF13651.6 CDI76124.1 - 0.049 12.9 1.2 0.068 12.4 1.2 1.2 1 0 0 1 1 1 0 Adenine-specific methyltransferase EcoRI Peptidase_S49_N PF08496.10 CDI76124.1 - 0.069 13.2 4.2 0.13 12.3 4.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Hydrolase PF00702.26 CDI76124.1 - 0.077 13.3 0.0 0.077 13.3 0.0 3.4 3 1 0 3 3 2 0 haloacid dehalogenase-like hydrolase Presenilin PF01080.17 CDI76124.1 - 0.085 11.6 2.4 0.14 10.9 2.4 1.3 1 0 0 1 1 1 0 Presenilin DUF2681 PF10883.8 CDI76124.1 - 1.1 9.7 14.7 3.2 8.2 14.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Activator_LAG-3 PF11498.8 CDI76124.1 - 1.8 7.4 24.1 2.9 6.8 24.1 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HAD_2 PF13419.6 CDI76124.1 - 3.7 7.6 7.3 16 5.5 0.0 3.3 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DivIC PF04977.15 CDI76124.1 - 4.4 7.1 12.5 8.4 6.2 12.5 1.4 1 0 0 1 1 1 0 Septum formation initiator LAG1-DNAbind PF09271.11 CDI76125.1 - 0.015 16.0 2.7 0.015 16.0 2.7 4.1 4 0 0 4 4 4 0 LAG1, DNA binding Antimicrobial11 PF08106.11 CDI76125.1 - 0.074 13.1 2.0 0.16 12.1 2.0 1.6 1 0 0 1 1 1 0 Formaecin family CTP_transf_1 PF01148.20 CDI76127.1 - 6.2e-07 29.4 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase family TCP PF03634.13 CDI76127.1 - 0.11 13.0 0.0 0.11 13.0 0.0 7.6 2 2 6 8 8 8 0 TCP family transcription factor MID_MedPIWI PF18296.1 CDI76128.1 - 0.0083 16.0 3.0 0.0095 15.7 3.0 1.0 1 0 0 1 1 1 1 MID domain of medPIWI Otopetrin PF03189.13 CDI76128.1 - 0.65 8.7 2.0 0.76 8.5 2.0 1.0 1 0 0 1 1 1 0 Otopetrin SOG2 PF10428.9 CDI76128.1 - 0.77 8.9 13.1 0.77 8.9 13.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 CDI76128.1 - 0.93 8.3 9.9 1 8.1 9.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI76128.1 - 1.3 7.5 12.9 1.6 7.2 12.9 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI76130.1 - 1.9 8.4 15.9 2.5 8.0 15.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IMUP PF15761.5 CDI76131.1 - 0.25 12.1 5.9 0.71 10.6 5.9 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein ATP_bind_1 PF03029.17 CDI76133.1 - 1.2e-49 169.3 0.0 1.5e-49 169.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 CDI76133.1 - 0.00017 21.4 0.0 0.022 14.6 0.0 2.2 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 CDI76133.1 - 0.0013 18.8 0.0 0.013 15.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI76133.1 - 0.0035 17.8 0.0 0.0049 17.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CDI76133.1 - 0.14 12.7 0.1 0.32 11.6 0.0 1.8 2 1 0 2 2 2 0 AAA domain SSP160 PF06933.11 CDI76133.1 - 9.6 4.3 11.0 12 4.0 11.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ATP_bind_1 PF03029.17 CDI76134.1 - 1.6e-13 51.0 0.0 2.3e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein WD40 PF00400.32 CDI76138.1 - 1e-06 29.4 0.1 2e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI76138.1 - 0.022 15.0 0.0 0.031 14.6 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Roughex PF06020.11 CDI76139.1 - 0.035 13.2 5.7 0.038 13.1 5.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein USP19_linker PF16602.5 CDI76139.1 - 0.066 13.8 4.4 0.061 13.9 1.5 1.8 1 1 1 2 2 2 0 Linker region of USP19 deubiquitinase TIMELESS_C PF05029.13 CDI76139.1 - 0.16 11.1 5.0 0.17 11.0 5.0 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region Androgen_recep PF02166.16 CDI76139.1 - 0.2 10.5 12.4 0.26 10.1 12.4 1.2 1 0 0 1 1 1 0 Androgen receptor Smg8_Smg9 PF10220.9 CDI76139.1 - 1.7 6.8 12.6 2 6.6 12.6 1.0 1 0 0 1 1 1 0 Smg8_Smg9 MPM1 PF17234.2 CDI76139.1 - 2.5 8.3 8.7 3.1 8.0 8.7 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Menin PF05053.13 CDI76139.1 - 3 6.1 10.9 3.4 5.9 10.9 1.0 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 CDI76139.1 - 8.4 4.8 18.1 8.9 4.7 18.1 1.0 1 0 0 1 1 1 0 Macoilin family Caldesmon PF02029.15 CDI76140.1 - 0.00035 19.5 36.2 0.00035 19.5 36.2 3.4 3 0 0 3 3 3 2 Caldesmon PAT1 PF09770.9 CDI76140.1 - 1.4 7.1 87.6 0.004 15.5 47.7 3.1 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 RskA PF10099.9 CDI76142.1 - 0.0027 18.0 5.4 0.0041 17.4 5.4 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA FHIPEP PF00771.20 CDI76142.1 - 0.13 10.7 1.5 0.2 10.1 1.5 1.3 1 0 0 1 1 1 0 FHIPEP family Utp14 PF04615.13 CDI76142.1 - 0.54 8.8 39.1 0.71 8.4 39.1 1.1 1 0 0 1 1 1 0 Utp14 protein Ribosomal_60s PF00428.19 CDI76142.1 - 4.7 7.9 7.9 12 6.6 7.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein PepSY_TM PF03929.16 CDI76142.1 - 5.5 6.6 5.7 4.6 6.8 4.8 1.3 1 1 0 1 1 1 0 PepSY-associated TM region 14-3-3 PF00244.20 CDI76144.1 - 9e-13 48.2 4.4 3e-06 26.9 0.0 3.0 3 0 0 3 3 3 2 14-3-3 protein Apc15p PF05841.11 CDI76144.1 - 0.081 13.7 0.4 0.081 13.7 0.4 2.9 3 0 0 3 3 3 0 Apc15p protein Spt20 PF12090.8 CDI76144.1 - 0.13 11.9 15.5 0.7 9.5 7.0 2.3 2 0 0 2 2 2 0 Spt20 family RAP1 PF07218.11 CDI76144.1 - 1.1 7.5 7.4 1.3 7.2 7.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.9 CDI76144.1 - 1.6 7.2 16.0 0.056 12.0 3.8 2.2 2 0 0 2 2 2 0 Macoilin family Apt1 PF10351.9 CDI76144.1 - 4 6.2 10.7 0.15 10.9 3.8 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain ATP11 PF06644.11 CDI76144.1 - 9.2 6.0 10.7 4.9 6.9 1.0 2.2 2 0 0 2 2 2 0 ATP11 protein SecY PF00344.20 CDI76145.1 - 1.2e-71 241.5 16.0 1.4e-71 241.3 16.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CDI76145.1 - 9.8e-18 63.7 1.1 2.3e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 Plug domain of Sec61p DUF2975 PF11188.8 CDI76145.1 - 3.1 7.7 9.1 1.9 8.4 1.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) Ribosomal_60s PF00428.19 CDI76146.1 - 0.59 10.7 5.8 0.84 10.3 5.8 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein RRM_1 PF00076.22 CDI76147.1 - 1.1e-36 124.4 0.0 2.1e-18 65.9 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CDI76147.1 - 0.00016 21.7 0.0 0.49 10.5 0.0 2.4 2 1 0 2 2 2 2 Limkain b1 RRM_3 PF08777.11 CDI76147.1 - 0.0002 21.4 0.0 0.47 10.5 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 CDI76147.1 - 0.02 14.9 0.0 5 7.2 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 CDI76147.1 - 0.024 14.7 0.0 11 6.2 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif DUF3343 PF11823.8 CDI76147.1 - 0.13 11.7 0.0 3.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) ATP-grasp_2 PF08442.10 CDI76147.1 - 0.23 11.0 0.0 0.23 11.0 0.0 2.4 3 0 0 3 3 3 0 ATP-grasp domain WD40 PF00400.32 CDI76148.1 - 5.5e-07 30.2 3.6 0.076 13.9 0.1 5.2 4 1 0 4 4 4 2 WD domain, G-beta repeat TFIIA PF03153.13 CDI76148.1 - 0.0013 18.8 25.7 0.0022 18.1 25.7 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI76148.1 - 0.14 10.4 21.8 0.19 10.0 21.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Draxin PF15550.6 CDI76148.1 - 0.23 11.3 9.8 0.44 10.4 9.8 1.4 1 0 0 1 1 1 0 Draxin Suf PF05843.14 CDI76148.1 - 1.9 8.4 21.6 3.4 7.6 21.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 CDI76148.1 - 3.9 4.5 13.6 5.4 4.0 13.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI76148.1 - 8.7 6.3 8.1 21 5.0 8.1 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ELK PF03789.13 CDI76149.1 - 0.15 12.2 0.1 0.6 10.2 0.0 1.9 2 0 0 2 2 2 0 ELK domain Guanylate_cyc PF00211.20 CDI76150.1 - 2.2e-19 69.8 0.0 6.2e-12 45.5 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain Cyclin_C_2 PF16899.5 CDI76151.1 - 0.097 13.1 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Cyclin C-terminal domain NCOA_u2 PF16665.5 CDI76151.1 - 0.11 12.8 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein DUF572 PF04502.13 CDI76152.1 - 4.4e-64 217.2 4.8 4.4e-64 217.2 4.8 3.5 3 0 0 3 3 3 2 Family of unknown function (DUF572) PAPS_reduct PF01507.19 CDI76152.1 - 0.72 9.9 4.9 13 5.8 1.1 3.5 2 1 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family DUF1911 PF08929.10 CDI76152.1 - 0.89 10.4 0.0 0.89 10.4 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1911) Ribosomal_L11_N PF03946.14 CDI76153.1 - 9.9e-23 79.8 0.1 2e-22 78.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDI76153.1 - 5.3e-22 78.1 0.0 8.5e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain NAD_binding_11 PF14833.6 CDI76153.1 - 0.095 12.9 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NifU_N PF01592.16 CDI76157.1 - 2e-48 163.8 0.1 2.4e-48 163.5 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain BT1 PF03092.16 CDI76158.1 - 9.6e-65 218.8 23.6 5.1e-39 133.9 8.1 3.0 3 0 0 3 3 3 3 BT1 family MFS_1 PF07690.16 CDI76158.1 - 9.2e-13 47.8 30.4 9.1e-08 31.4 9.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CDI76158.1 - 0.00019 20.4 0.0 0.00044 19.2 0.0 1.6 1 1 0 1 1 1 1 MFS_1 like family Evr1_Alr PF04777.13 CDI76159.1 - 0.0063 17.0 0.0 0.016 15.7 0.0 1.6 1 0 0 1 1 1 1 Erv1 / Alr family Totivirus_coat PF05518.11 CDI76159.1 - 0.041 11.9 5.2 0.051 11.6 5.2 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ribosomal_60s PF00428.19 CDI76161.1 - 0.0066 17.0 1.2 0.0066 17.0 1.2 5.8 3 2 2 5 5 5 1 60s Acidic ribosomal protein PI3K_1B_p101 PF10486.9 CDI76161.1 - 0.67 7.7 2.7 0.81 7.4 2.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF3915 PF13054.6 CDI76161.1 - 1.9 8.5 4.7 2.5 8.1 4.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) SMC_N PF02463.19 CDI76162.1 - 3.2e-09 36.6 0.0 6.8e-08 32.2 0.0 2.5 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SR-25 PF10500.9 CDI76162.1 - 4.6e-05 23.2 26.2 4.6e-05 23.2 26.2 7.9 6 2 0 6 6 6 1 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI76162.1 - 0.0054 16.7 7.7 0.0054 16.7 7.7 5.4 2 1 1 3 3 3 1 SPX domain DUF4207 PF13904.6 CDI76162.1 - 0.0061 16.3 29.7 0.0061 16.3 29.7 7.2 5 2 2 7 7 7 1 Domain of unknown function (DUF4207) RNA_pol_Rpb5_C PF01191.19 CDI76163.1 - 1.7e-32 111.1 0.3 1.7e-32 111.1 0.3 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 CDI76163.1 - 8.2e-14 52.0 0.0 8.2e-14 52.0 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain RskA PF10099.9 CDI76163.1 - 0.0021 18.4 21.7 0.0021 18.4 21.7 6.6 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Mrr_cat PF04471.12 CDI76163.1 - 0.0027 17.7 1.5 0.0043 17.1 0.0 2.1 2 0 0 2 2 2 1 Restriction endonuclease RNA_pol_Rbc25 PF08292.12 CDI76163.1 - 0.44 10.8 9.1 5.2 7.3 4.1 2.6 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 SARAF PF06682.12 CDI76163.1 - 0.88 9.2 12.1 1.5 8.4 12.1 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis EPL1 PF10513.9 CDI76163.1 - 0.95 9.8 19.0 0.73 10.2 10.4 2.9 3 0 0 3 3 3 0 Enhancer of polycomb-like OAD_gamma PF04277.13 CDI76163.1 - 4.1 8.1 0.0 4.1 8.1 0.0 10.8 2 2 3 5 5 5 0 Oxaloacetate decarboxylase, gamma chain SRP68 PF16969.5 CDI76166.1 - 3.9e-24 85.6 23.9 3.9e-24 85.6 23.9 2.7 2 1 0 2 2 2 1 RNA-binding signal recognition particle 68 Hydrolase_6 PF13344.6 CDI76166.1 - 0.13 12.3 0.2 0.4 10.8 0.2 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DnaJ_C PF01556.18 CDI76172.1 - 1.3e-17 64.2 0.0 2e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDI76172.1 - 8.4e-14 51.5 0.1 2.3e-10 40.5 0.0 2.4 2 0 0 2 2 2 2 DnaJ domain PRIMA1 PF16101.5 CDI76172.1 - 1.1 9.3 24.4 1.3 9.0 14.1 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 RNA_pol_Rpb1_5 PF04998.17 CDI76181.1 - 8.1e-18 64.8 0.2 1e-17 64.5 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 NiFe-hyd_HybE PF11939.8 CDI76181.1 - 0.065 13.1 0.5 0.11 12.4 0.5 1.3 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE DUF2057 PF09829.9 CDI76181.1 - 1.5 8.9 5.7 2.1 8.5 5.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) SAP PF02037.27 CDI76182.1 - 2.3e-13 49.5 1.9 5.6e-13 48.3 0.1 2.2 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 CDI76182.1 - 0.0023 17.7 6.4 0.024 14.4 1.7 2.5 1 1 1 2 2 2 2 Tho1/MOS11 C-terminal domain HeH PF12949.7 CDI76182.1 - 0.0088 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 HeH/LEM domain Tic110 PF16940.5 CDI76182.1 - 0.13 10.8 7.5 0.22 10.0 7.5 1.3 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF2722 PF10846.8 CDI76185.1 - 0.0039 16.2 1.5 0.0039 16.2 1.5 3.0 2 1 1 3 3 1 1 Protein of unknown function (DUF2722) Tom22 PF04281.13 CDI76185.1 - 0.0059 16.4 12.4 0.0059 16.4 12.4 1.9 2 0 0 2 2 1 1 Mitochondrial import receptor subunit Tom22 Peptidase_C37 PF05416.12 CDI76185.1 - 0.0067 15.0 2.2 0.013 14.1 2.2 1.4 1 0 0 1 1 1 1 Southampton virus-type processing peptidase FGF-BP1 PF06473.12 CDI76185.1 - 0.007 16.2 17.8 0.029 14.2 7.0 2.4 2 0 0 2 2 2 2 FGF binding protein 1 (FGF-BP1) Rxt3 PF08642.10 CDI76185.1 - 0.031 15.0 2.8 3.7 8.3 1.0 2.7 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 SpoIIP PF07454.11 CDI76185.1 - 0.083 12.3 14.6 0.2 11.1 6.7 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF789 PF05623.12 CDI76185.1 - 0.085 12.5 12.1 0.025 14.3 5.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF789) DUF2828 PF11443.8 CDI76185.1 - 0.11 10.6 12.7 0.027 12.6 5.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF719 PF05334.13 CDI76185.1 - 0.24 11.6 14.8 0.46 10.7 4.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF719) DcuA_DcuB PF03605.14 CDI76185.1 - 0.27 10.1 7.7 0.016 14.1 1.3 1.9 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Peroxin-13_N PF04088.13 CDI76185.1 - 0.82 9.9 7.5 2.2 8.6 1.9 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Tim54 PF11711.8 CDI76185.1 - 1 8.1 15.2 2.3 6.9 9.1 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4820 PF16091.5 CDI76185.1 - 1.1 8.6 17.6 1.1 8.5 9.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF3405 PF11885.8 CDI76185.1 - 1.2 7.7 9.2 0.25 9.9 2.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) Peptidase_S49_N PF08496.10 CDI76185.1 - 1.2 9.2 12.9 6.8 6.7 0.9 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal UPF0524 PF15823.5 CDI76185.1 - 1.5 8.2 6.0 12 5.2 0.2 2.3 2 0 0 2 2 2 0 UPF0524 of C3orf70 Orf78 PF06024.12 CDI76185.1 - 1.5 9.1 8.9 0.91 9.9 1.8 2.6 2 0 0 2 2 2 0 Orf78 (ac78) Suf PF05843.14 CDI76185.1 - 1.6 8.6 26.7 4.5 7.2 2.1 2.4 2 1 0 2 2 2 0 Suppressor of forked protein (Suf) Rsc14 PF08586.10 CDI76185.1 - 1.7 9.5 15.2 0.34 11.7 1.8 2.6 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit OATP PF03137.20 CDI76185.1 - 1.9 6.7 6.2 1.8 6.7 2.6 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.19 CDI76185.1 - 2.2 8.0 15.3 0.37 10.5 4.3 3.0 3 0 0 3 3 3 0 Connexin CTU2 PF10288.9 CDI76185.1 - 2.7 8.2 14.7 6.1 7.1 0.0 2.8 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 MRNIP PF15749.5 CDI76185.1 - 2.8 8.7 25.7 2.6 8.8 2.9 3.1 3 0 0 3 3 3 0 MRN-interacting protein FAM176 PF14851.6 CDI76185.1 - 2.8 7.6 12.8 1.8 8.2 4.4 2.6 3 0 0 3 3 2 0 FAM176 family DUF1644 PF07800.12 CDI76185.1 - 3.2 7.8 7.1 46 4.0 5.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) HA2 PF04408.23 CDI76185.1 - 3.3 8.0 10.1 5.3 7.4 4.7 2.7 2 0 0 2 2 2 0 Helicase associated domain (HA2) Zip PF02535.22 CDI76185.1 - 3.4 6.8 10.9 0.11 11.7 3.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter DUF572 PF04502.13 CDI76185.1 - 3.6 7.1 21.7 0.29 10.7 10.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) FPN1 PF06963.12 CDI76185.1 - 3.6 6.0 9.5 4.8 5.6 3.4 2.3 2 0 0 2 2 2 0 Ferroportin1 (FPN1) Renin_r PF07850.14 CDI76185.1 - 3.8 8.2 6.7 4.5 7.9 1.0 2.5 2 0 0 2 2 2 0 Renin receptor-like protein TRAP_alpha PF03896.16 CDI76185.1 - 5.4 6.1 8.3 1.7 7.8 2.7 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit RPA43_OB PF17875.1 CDI76185.1 - 5.5 7.6 12.3 21 5.8 6.1 2.5 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I EIIBC-GUT_N PF03612.14 CDI76185.1 - 5.9 6.6 16.6 8.3 6.1 0.4 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus IHABP4_N PF16174.5 CDI76185.1 - 7 7.2 25.1 3.8 8.1 11.7 2.9 3 0 0 3 3 3 0 Intracellular hyaluronan-binding protein 4 N-terminal CLN3 PF02487.17 CDI76185.1 - 7.5 5.5 12.2 3.5 6.6 5.8 2.3 2 0 0 2 2 2 0 CLN3 protein AIF_C PF14721.6 CDI76185.1 - 7.9 6.9 15.7 26 5.2 0.3 2.6 3 0 0 3 3 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4834 PF16118.5 CDI76185.1 - 8.3 7.4 23.4 1.4 9.9 1.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) RuvC_III PF18541.1 CDI76185.1 - 8.5 6.3 14.5 13 5.7 1.2 2.3 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 V_ATPase_I PF01496.19 CDI76185.1 - 8.5 4.1 14.8 2.8 5.7 6.5 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Sec62 PF03839.16 CDI76185.1 - 8.6 5.8 12.6 8 5.9 5.3 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 DUF3408 PF11888.8 CDI76185.1 - 9.2 6.4 21.3 16 5.7 12.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) AMP-binding PF00501.28 CDI76186.1 - 5.8e-33 114.1 0.0 7.2e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Spore_YpjB PF09577.10 CDI76187.1 - 0.0093 15.8 9.2 0.0093 15.8 9.2 2.2 2 1 0 2 2 2 1 Sporulation protein YpjB (SpoYpjB) Spt20 PF12090.8 CDI76187.1 - 0.051 13.2 47.9 0.16 11.6 12.2 2.2 2 0 0 2 2 2 0 Spt20 family PRIMA1 PF16101.5 CDI76187.1 - 0.17 11.9 0.3 0.17 11.9 0.3 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 GCFC PF07842.12 CDI76188.1 - 6.6e-31 107.9 15.9 6.6e-31 107.9 15.9 3.2 3 1 0 3 3 3 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 CDI76188.1 - 4.5e-08 32.9 2.9 1.2e-07 31.5 2.9 1.7 1 0 0 1 1 1 1 G-patch domain SUIM_assoc PF16619.5 CDI76188.1 - 0.00034 20.6 3.5 0.0091 16.0 0.1 13.4 10 4 1 11 11 11 4 Unstructured region C-term to UIM in Ataxin3 TIP_N PF12457.8 CDI76188.1 - 0.0058 17.0 8.4 0.0058 17.0 8.4 6.3 4 2 3 7 7 7 1 Tuftelin interacting protein N terminal RskA PF10099.9 CDI76188.1 - 0.0089 16.3 1.9 0.0089 16.3 1.9 7.5 4 4 2 6 6 6 1 Anti-sigma-K factor rskA DUF5449 PF17528.2 CDI76188.1 - 0.066 13.0 0.6 4.5 7.0 0.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5449) ERCC4 PF02732.15 CDI76189.1 - 1.3e-10 41.7 8.6 1.6e-10 41.4 0.0 4.4 4 1 0 4 4 4 1 ERCC4 domain DUF3273 PF11677.8 CDI76195.1 - 7.3e-27 94.3 0.0 8.1e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Dynein_light PF01221.18 CDI76196.1 - 2.4e-23 82.2 0.0 3.2e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 DUF5101 PF17031.5 CDI76196.1 - 0.1 12.7 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) HOIP-UBA PF16678.5 CDI76197.1 - 0.099 12.6 3.3 0.16 12.0 3.3 1.5 1 1 0 1 1 1 0 HOIP UBA domain pair MAS20 PF02064.15 CDI76197.1 - 1.4 9.0 6.1 1.5 8.9 4.6 1.7 1 1 1 2 2 2 0 MAS20 protein import receptor Wbp11 PF09429.10 CDI76198.1 - 7.9e-12 45.4 11.3 7.9e-12 45.4 11.3 2.6 2 1 0 2 2 2 1 WW domain binding protein 11 Barttin PF15462.6 CDI76200.1 - 0.053 13.3 3.2 0.088 12.6 3.2 1.3 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) RabGAP-TBC PF00566.18 CDI76201.1 - 1.5e-44 152.2 0.0 1.5e-44 152.2 0.0 2.6 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Spt20 PF12090.8 CDI76201.1 - 0.71 9.4 21.1 0.026 14.1 2.2 2.5 2 0 0 2 2 2 0 Spt20 family zinc_ribbon_6 PF14599.6 CDI76202.1 - 6.1e-22 77.4 0.6 6.1e-22 77.4 0.6 3.8 4 1 0 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 CDI76202.1 - 3e-11 43.6 47.5 9.8e-11 42.0 33.9 3.5 1 1 2 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 CDI76202.1 - 1.8e-07 31.3 4.8 1.8e-07 31.3 4.8 4.9 3 1 1 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 CDI76202.1 - 2.8e-07 30.4 2.7 2.8e-07 30.4 2.7 3.9 4 1 0 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI76202.1 - 0.00018 21.4 8.6 0.00018 21.4 8.6 5.4 3 2 1 4 4 4 2 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDI76202.1 - 0.002 18.2 1.5 0.002 18.2 1.5 4.7 4 2 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 CDI76202.1 - 0.0036 17.0 1.9 0.0036 17.0 1.9 5.0 7 0 0 7 7 7 1 RING-like zinc finger DUF2058 PF09831.9 CDI76203.1 - 6.9 6.8 9.6 13 5.9 9.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Presenilin PF01080.17 CDI76203.1 - 7.4 5.2 7.2 8.7 5.0 7.2 1.2 1 0 0 1 1 1 0 Presenilin DnaJ PF00226.31 CDI76204.1 - 1.2e-17 63.7 5.4 1.5e-11 44.2 0.1 3.4 3 0 0 3 3 3 2 DnaJ domain Myb_DNA-binding PF00249.31 CDI76204.1 - 2.3e-06 27.7 0.1 9.1e-06 25.8 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDI76204.1 - 0.0023 18.2 0.0 0.0023 18.2 0.0 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Ham1p_like PF01725.16 CDI76204.1 - 0.058 13.3 0.3 0.058 13.3 0.3 2.1 2 0 0 2 2 2 0 Ham1 family DDRGK PF09756.9 CDI76204.1 - 0.094 12.3 37.0 0.22 11.1 20.2 2.6 2 0 0 2 2 2 0 DDRGK domain MAT1 PF06391.13 CDI76204.1 - 1.1 9.0 27.7 2.6 7.8 7.6 2.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 CAF-1_p150 PF11600.8 CDI76204.1 - 5.4 6.7 48.1 1.5 8.5 32.1 2.4 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CRAL_TRIO PF00650.20 CDI76205.1 - 2.1e-20 73.1 0.0 2.9e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDI76205.1 - 0.00029 21.0 0.0 0.00062 19.9 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CDI76205.1 - 0.0062 16.7 1.0 0.014 15.6 1.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Utp14 PF04615.13 CDI76208.1 - 0.027 13.1 16.1 0.04 12.5 16.1 1.2 1 0 0 1 1 1 0 Utp14 protein Cwf_Cwc_15 PF04889.12 CDI76208.1 - 0.22 11.2 20.8 0.71 9.6 7.3 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Zip PF02535.22 CDI76208.1 - 0.53 9.5 1.8 1.2 8.3 1.8 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 CDI76208.1 - 0.73 9.6 1.5 1.2 8.9 1.5 1.3 1 0 0 1 1 1 0 Connexin Gti1_Pac2 PF09729.9 CDI76208.1 - 0.76 9.8 6.9 2.5 8.2 6.9 1.8 1 0 0 1 1 1 0 Gti1/Pac2 family PRIMA1 PF16101.5 CDI76208.1 - 1.3 9.1 5.4 3.5 7.7 5.4 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Peptidase_S64 PF08192.11 CDI76208.1 - 1.5 7.2 5.9 2.4 6.5 5.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.7 CDI76208.1 - 1.6 6.8 4.5 2.2 6.3 4.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 CDI76208.1 - 1.8 6.8 16.3 0.3 9.3 6.7 2.1 2 0 0 2 2 2 0 CDC45-like protein Afi1 PF07792.12 CDI76208.1 - 3 8.4 17.0 50 4.4 0.0 3.2 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4637 PF15470.6 CDI76208.1 - 3.4 7.4 11.5 0.41 10.3 3.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Vfa1 PF08432.10 CDI76208.1 - 3.6 7.9 18.9 1.5 9.1 12.3 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 CDI76208.1 - 7.8 5.1 10.9 0.23 10.2 4.7 1.5 2 0 0 2 2 2 0 Presenilin RNA_pol_3_Rpc31 PF11705.8 CDI76208.1 - 7.8 6.7 19.2 3.1 8.0 0.7 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Cpn60_TCP1 PF00118.24 CDI76209.1 - 2.9e-165 550.6 6.1 3.3e-165 550.4 6.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Longin PF13774.6 CDI76212.1 - 4.2e-13 49.1 0.0 7.1e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 CDI76212.1 - 4.6e-09 36.0 2.9 4.8e-09 35.9 0.5 2.0 2 0 0 2 2 2 1 Synaptobrevin HMG_box PF00505.19 CDI76213.1 - 2.5e-19 69.4 2.1 3.5e-19 69.0 2.1 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDI76213.1 - 3.8e-10 40.2 3.0 5.4e-10 39.7 3.0 1.3 1 0 0 1 1 1 1 HMG-box domain MlaC PF05494.12 CDI76213.1 - 0.0054 16.5 1.1 0.0075 16.0 1.1 1.2 1 0 0 1 1 1 1 MlaC protein RAP1 PF07218.11 CDI76213.1 - 0.095 11.0 8.6 0.1 10.9 8.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AF-4 PF05110.13 CDI76213.1 - 0.14 10.3 14.9 0.13 10.3 14.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Syntaphilin PF15290.6 CDI76213.1 - 0.15 11.6 3.3 0.16 11.6 3.3 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp SR-25 PF10500.9 CDI76213.1 - 0.25 10.9 23.5 0.35 10.5 23.6 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein NAM-associated PF14303.6 CDI76215.1 - 0.023 15.5 0.0 0.023 15.5 0.0 9.0 4 2 4 8 8 8 0 No apical meristem-associated C-terminal domain Ras PF00071.22 CDI76217.1 - 2.4e-19 69.5 0.4 2.8e-19 69.3 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI76217.1 - 2.8e-13 50.1 2.0 6.4e-13 49.0 2.1 1.5 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CDI76217.1 - 0.0012 18.6 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain SurA_N_2 PF13623.6 CDI76217.1 - 0.0023 17.8 6.8 0.0023 17.8 6.8 1.1 1 0 0 1 1 1 1 SurA N-terminal domain ABC_tran PF00005.27 CDI76217.1 - 0.0043 17.6 1.5 0.0065 17.0 1.5 1.3 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 CDI76217.1 - 0.0058 16.7 0.0 0.0074 16.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DAP3 PF10236.9 CDI76217.1 - 0.0084 15.3 1.1 0.044 12.9 0.0 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CDI76217.1 - 0.012 16.0 0.2 0.017 15.5 0.2 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CDI76217.1 - 0.014 15.6 1.4 0.028 14.7 1.4 1.5 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDI76217.1 - 0.042 13.4 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDI76217.1 - 0.1 12.3 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI76217.1 - 0.13 12.2 3.0 0.57 10.1 2.2 1.9 1 1 1 2 2 2 0 RsgA GTPase Spt20 PF12090.8 CDI76217.1 - 0.15 11.7 13.4 0.15 11.6 13.4 1.1 1 0 0 1 1 1 0 Spt20 family CcmD PF04995.14 CDI76217.1 - 5.2 7.2 8.0 11 6.1 8.0 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF3527 PF12043.8 CDI76218.1 - 0.14 11.7 17.5 0.18 11.4 17.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) LAP1C PF05609.12 CDI76218.1 - 9.4 5.2 33.4 11 4.9 33.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WD40 PF00400.32 CDI76219.1 - 6.1e-12 45.9 10.6 0.0045 17.8 0.0 7.8 8 0 0 8 8 8 4 WD domain, G-beta repeat zf-C6H2 PF15801.5 CDI76220.1 - 7.8e-12 45.3 9.6 1.3e-11 44.6 9.6 1.3 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 CDI76220.1 - 0.014 15.5 10.8 0.022 14.8 10.8 1.4 1 0 0 1 1 1 0 MYND finger DUF3752 PF12572.8 CDI76220.1 - 0.77 10.3 9.4 0.4 11.2 6.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3752) Pkinase PF00069.25 CDI76221.1 - 7.2e-45 153.4 0.6 1.5e-24 86.8 0.9 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76221.1 - 3e-20 72.6 0.3 7.6e-15 54.9 0.8 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase PH PF00169.29 CDI76221.1 - 6e-14 52.4 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 CDI76221.1 - 2.6e-10 39.1 0.6 0.00016 21.0 0.1 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CDI76221.1 - 6.5e-10 38.1 0.2 6.8e-05 22.5 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDI76221.1 - 5e-08 32.1 0.8 0.00022 20.6 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 CDI76221.1 - 9e-06 26.1 1.0 8.8e-05 22.9 0.1 3.0 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 CDI76221.1 - 4.2e-05 23.3 2.7 0.0023 17.7 0.3 3.1 2 1 1 3 3 3 2 EF-hand domain pair PH_8 PF15409.6 CDI76221.1 - 0.0045 17.2 0.1 0.016 15.5 0.1 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain eIF-1a PF01176.19 CDI76223.1 - 1.1e-10 41.2 0.0 3.6e-10 39.5 0.0 1.7 1 1 0 1 1 1 1 Translation initiation factor 1A / IF-1 Dehydrin PF00257.19 CDI76223.1 - 0.0011 19.5 0.7 0.0015 19.1 0.7 1.2 1 0 0 1 1 1 1 Dehydrin IMUP PF15761.5 CDI76223.1 - 0.038 14.7 7.8 0.08 13.6 7.8 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein FlgH PF02107.16 CDI76223.1 - 0.082 12.5 0.4 0.12 12.0 0.4 1.1 1 0 0 1 1 1 0 Flagellar L-ring protein SR-25 PF10500.9 CDI76223.1 - 0.99 9.0 11.5 1.4 8.4 11.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GreA_GreB_N PF03449.15 CDI76224.1 - 0.011 15.9 5.1 0.38 11.0 1.2 3.1 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal DivIC PF04977.15 CDI76224.1 - 0.015 15.1 3.0 0.015 15.1 3.0 4.2 4 1 1 5 5 5 0 Septum formation initiator DUF2052 PF09747.9 CDI76224.1 - 4.8 7.3 31.4 0.21 11.7 8.4 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Ephrin_rec_like PF07699.13 CDI76225.1 - 1.2e-05 25.0 9.1 0.13 12.1 0.1 3.9 4 0 0 4 4 4 3 Putative ephrin-receptor like RANK_CRD_2 PF18278.1 CDI76225.1 - 3.1e-05 24.0 0.4 0.00053 20.1 0.1 2.7 2 0 0 2 2 2 1 Receptor activator of the NF-KB cysteine-rich repeat domain 2 FXa_inhibition PF14670.6 CDI76225.1 - 0.077 13.3 6.7 0.37 11.1 4.2 2.9 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDI76225.1 - 0.084 12.8 6.3 1.9 8.5 0.6 3.5 3 0 0 3 3 3 0 Complement Clr-like EGF-like EGF_3 PF12947.7 CDI76225.1 - 3.2 8.0 5.9 2.2 8.6 0.4 3.0 3 0 0 3 3 3 0 EGF domain EGF_MSP1_1 PF12946.7 CDI76225.1 - 4.5 7.4 10.0 0.18 11.9 1.2 3.3 4 1 0 4 4 4 0 MSP1 EGF domain 1 PT PF04886.12 CDI76226.1 - 0.35 10.4 3.7 1.8 8.2 0.2 2.4 2 0 0 2 2 2 0 PT repeat Gly-zipper_OmpA PF13436.6 CDI76226.1 - 3 7.7 10.4 1.6 8.5 0.2 3.3 3 1 0 3 3 3 0 Glycine-zipper domain DUF4614 PF15391.6 CDI76227.1 - 0.014 15.4 4.4 0.014 15.4 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) FAP PF07174.11 CDI76227.1 - 3 7.2 34.0 2.9 7.3 34.0 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DUF4813 PF16072.5 CDI76227.1 - 4.8 6.8 37.8 5.4 6.6 37.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) DUF1635 PF07795.11 CDI76227.1 - 5.3 6.8 7.6 5.8 6.7 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF2722 PF10846.8 CDI76228.1 - 0.00026 20.1 11.8 0.00026 20.1 11.8 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI76228.1 - 0.0024 18.0 23.5 0.0024 18.0 23.5 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI76228.1 - 0.29 11.5 6.8 0.16 12.3 4.6 1.7 2 0 0 2 2 2 0 Enhancer of polycomb-like Tristanin_u2 PF16638.5 CDI76228.1 - 0.95 10.3 10.7 21 5.9 0.0 2.5 2 0 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers DUF4746 PF15928.5 CDI76228.1 - 1.5 8.2 4.3 2.2 7.7 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Band_3_cyto PF07565.13 CDI76228.1 - 1.5 8.5 4.9 3 7.6 4.9 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spt20 PF12090.8 CDI76228.1 - 1.8 8.1 35.7 3 7.4 35.7 1.3 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.9 CDI76228.1 - 2.3 6.4 15.5 3.1 5.9 15.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 CDI76228.1 - 2.6 7.4 9.1 3.9 6.8 9.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Apt1 PF10351.9 CDI76228.1 - 5.1 5.8 11.3 10 4.8 6.1 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain GREB1 PF15782.5 CDI76228.1 - 9.9 3.1 11.6 18 2.3 11.6 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Glyco_transf_8 PF01501.20 CDI76229.1 - 1.7e-05 24.5 7.8 1.7e-05 24.5 7.8 3.2 3 1 0 3 3 3 1 Glycosyl transferase family 8 SAPS PF04499.15 CDI76229.1 - 0.002 17.0 2.9 0.002 17.0 2.9 4.0 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein Zip PF02535.22 CDI76229.1 - 0.0022 17.3 4.1 0.0022 17.3 4.1 4.2 4 1 0 4 4 4 1 ZIP Zinc transporter SART-1 PF03343.13 CDI76230.1 - 1.2e-56 192.6 77.2 1.3e-28 99.9 60.3 4.5 1 1 2 3 3 3 3 SART-1 family MPP6 PF10175.9 CDI76231.1 - 9.1e-05 23.0 0.3 0.00015 22.3 0.3 1.4 1 1 0 1 1 1 1 M-phase phosphoprotein 6 K_channel_TID PF07941.11 CDI76231.1 - 0.015 15.7 7.4 0.015 15.7 7.4 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain SUIM_assoc PF16619.5 CDI76231.1 - 0.08 13.0 6.8 0.23 11.6 6.8 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI76231.1 - 0.11 12.8 12.1 0.19 12.0 12.1 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI76231.1 - 0.12 12.0 4.8 0.13 11.9 4.8 1.1 1 0 0 1 1 1 0 Spt20 family Adeno_PIX PF03955.14 CDI76231.1 - 0.2 11.8 0.5 0.2 11.8 0.5 1.8 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) TFIIA PF03153.13 CDI76231.1 - 0.36 10.8 7.1 0.43 10.5 7.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4179 PF13786.6 CDI76231.1 - 0.81 10.2 2.6 8.6 6.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Chorion_2 PF03964.15 CDI76231.1 - 1.1 10.1 7.7 0.59 11.0 4.2 1.9 2 0 0 2 2 2 0 Chorion family 2 Ribosomal_60s PF00428.19 CDI76231.1 - 1.8 9.2 9.8 1.3 9.6 3.3 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Sec16_C PF12931.7 CDI76234.1 - 1.1e-11 45.0 10.1 1.1e-11 45.0 10.1 4.8 3 3 0 3 3 3 1 Sec23-binding domain of Sec16 HTH_30 PF13556.6 CDI76234.1 - 4.6 7.1 5.5 2.3 8.1 0.1 3.0 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain SIR2 PF02146.17 CDI76235.1 - 6.1e-15 55.6 0.0 1e-07 32.1 0.1 4.0 5 1 0 5 5 5 2 Sir2 family TFIIA PF03153.13 CDI76237.1 - 1.6e-08 35.0 120.2 0.00027 21.1 36.5 6.0 6 0 0 6 6 6 5 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI76237.1 - 0.001 18.7 13.1 0.001 18.7 13.1 7.0 7 1 1 8 8 8 1 Nuclear RNA-splicing-associated protein Pex14_N PF04695.13 CDI76237.1 - 0.0015 19.2 19.1 0.0015 19.2 19.1 8.5 9 1 1 10 10 10 2 Peroxisomal membrane anchor protein (Pex14p) conserved region FmiP_Thoc5 PF09766.9 CDI76237.1 - 0.0054 16.1 0.2 0.0054 16.1 0.2 6.0 5 1 1 6 6 6 1 Fms-interacting protein/Thoc5 CagX PF03524.15 CDI76237.1 - 0.036 13.8 0.0 0.036 13.8 0.0 5.6 6 0 0 6 6 6 0 Conjugal transfer protein Cnd2 PF05786.14 CDI76238.1 - 2.5e-23 82.7 32.9 1.4e-16 60.4 10.8 3.9 3 2 0 3 3 3 2 Condensin complex subunit 2 DUF755 PF05501.11 CDI76238.1 - 0.0015 18.8 26.4 0.0015 18.8 26.4 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF755) CNDH2_N PF06278.11 CDI76238.1 - 0.046 13.9 0.5 0.046 13.9 0.5 4.0 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Endostatin PF06482.11 CDI76238.1 - 0.58 9.6 11.8 1.1 8.7 7.6 2.5 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin AF-4 PF05110.13 CDI76238.1 - 7 4.6 30.8 0.069 11.2 20.6 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein RskA PF10099.9 CDI76238.1 - 7.5 6.8 50.4 9.4 6.5 11.4 5.7 4 2 0 4 4 4 0 Anti-sigma-K factor rskA EOS1 PF12326.8 CDI76238.1 - 8.7 6.2 6.1 2.9 7.8 1.3 2.4 3 0 0 3 3 3 0 N-glycosylation protein PAN_1 PF00024.26 CDI76239.1 - 1.7e-12 47.1 17.5 2.3e-06 27.5 1.4 4.3 3 1 1 4 4 4 4 PAN domain PAN_4 PF14295.6 CDI76239.1 - 1.3e-10 41.0 22.9 0.0003 20.6 0.7 5.0 4 1 0 4 4 4 3 PAN domain PAN_3 PF08277.12 CDI76239.1 - 0.59 10.0 12.9 1 9.2 0.6 3.4 2 1 1 3 3 3 0 PAN-like domain MANEC PF07502.14 CDI76239.1 - 1.2 9.5 16.0 0.39 11.0 0.8 3.8 3 1 1 4 4 4 0 MANEC domain PAN_2 PF08276.11 CDI76239.1 - 1.7 8.8 14.9 0.3 11.2 0.6 3.0 3 0 0 3 3 3 0 PAN-like domain Utp14 PF04615.13 CDI76240.1 - 1.2 7.6 38.3 1.3 7.5 38.3 1.1 1 0 0 1 1 1 0 Utp14 protein ABC_membrane_3 PF13748.6 CDI76241.1 - 0.36 10.0 3.0 0.96 8.6 3.0 1.7 1 0 0 1 1 1 0 ABC transporter transmembrane region RabGAP-TBC PF00566.18 CDI76244.1 - 2.7e-22 79.5 0.6 2.7e-22 79.5 0.6 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Pkinase PF00069.25 CDI76244.1 - 3.2e-12 46.4 0.0 4.3e-07 29.6 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76244.1 - 1.1e-06 28.2 0.0 1.5e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Rhodanese PF00581.20 CDI76244.1 - 0.0049 17.4 0.1 11 6.6 0.0 3.7 5 0 0 5 5 5 2 Rhodanese-like domain DUF4578 PF15147.6 CDI76244.1 - 3.4 8.6 9.1 2.5 9.0 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) zf-CCCH PF00642.24 CDI76245.1 - 7e-11 41.8 13.7 1.8e-05 24.5 1.9 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI76245.1 - 2.4e-05 24.2 15.9 0.0098 15.9 5.7 2.9 3 1 0 3 3 3 2 Zinc finger domain Torus PF16131.5 CDI76245.1 - 4.1e-05 24.2 1.3 0.079 13.7 0.1 2.3 2 0 0 2 2 2 2 Torus domain RRM_1 PF00076.22 CDI76245.1 - 5.3e-05 23.0 0.0 0.00012 21.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 CDI76245.1 - 0.92 9.4 16.2 2.8 7.9 6.6 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger Vps35 PF03635.17 CDI76247.1 - 0.055 12.0 6.5 0.0049 15.4 1.4 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 35 DUF4481 PF14800.6 CDI76248.1 - 0.24 10.8 2.8 0.37 10.2 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) JmjC PF02373.22 CDI76249.1 - 2.7e-20 72.9 0.1 2.7e-20 72.9 0.1 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 CDI76249.1 - 8e-16 58.5 5.5 3.9e-12 46.4 0.0 3.0 3 1 1 4 4 4 2 Cupin-like domain Cupin_4 PF08007.12 CDI76249.1 - 0.014 14.9 0.7 0.035 13.6 0.0 2.1 2 1 0 2 2 2 0 Cupin superfamily protein DUF3446 PF11928.8 CDI76249.1 - 0.029 14.7 2.0 0.029 14.7 2.0 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain GPI PF06560.11 CDI76249.1 - 0.074 12.3 0.1 0.21 10.9 0.1 1.7 2 0 0 2 2 2 0 Glucose-6-phosphate isomerase (GPI) Cupin_2 PF07883.11 CDI76249.1 - 0.082 12.6 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Cupin domain L51_S25_CI-B8 PF05047.16 CDI76249.1 - 0.11 12.4 1.7 0.35 10.8 0.3 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Mlo PF03094.15 CDI76250.1 - 2.2e-08 32.9 8.6 4.1e-07 28.7 1.8 3.5 3 1 1 4 4 4 2 Mlo family Sigma_reg_N PF13800.6 CDI76250.1 - 0.016 15.4 1.4 5 7.5 0.0 3.6 3 0 0 3 3 3 0 Sigma factor regulator N-terminal COX2_TM PF02790.15 CDI76250.1 - 0.16 12.1 0.1 0.16 12.1 0.1 2.8 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4834 PF16118.5 CDI76250.1 - 5.8 8.0 9.2 25 5.9 1.3 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) UCH PF00443.29 CDI76252.1 - 2.5e-65 220.5 0.0 4.1e-64 216.5 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDI76252.1 - 3.8e-14 53.0 0.0 1.4e-09 38.0 0.0 3.9 2 2 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RskA PF10099.9 CDI76252.1 - 0.6 10.4 21.5 0.48 10.7 1.2 3.8 3 0 0 3 3 3 0 Anti-sigma-K factor rskA LCCL PF03815.19 CDI76253.1 - 2e-21 75.9 0.6 1.5e-18 66.7 0.2 2.4 2 0 0 2 2 2 2 LCCL domain Laminin_G_3 PF13385.6 CDI76253.1 - 7.3e-05 23.0 0.0 0.00013 22.1 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Med15 PF09606.10 CDI76253.1 - 0.0012 17.7 3.9 0.0014 17.4 3.9 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Rxt3 PF08642.10 CDI76253.1 - 0.0014 19.4 0.4 0.02 15.7 0.0 2.2 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 SUIM_assoc PF16619.5 CDI76253.1 - 0.0015 18.5 3.3 0.0033 17.4 3.3 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI76253.1 - 0.0025 18.2 1.4 0.004 17.5 1.4 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI76253.1 - 0.0055 16.7 2.1 0.0066 16.5 2.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI76253.1 - 0.0092 15.0 0.5 0.011 14.7 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Phostensin_N PF13916.6 CDI76253.1 - 0.11 12.9 1.6 0.18 12.1 1.6 1.3 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Spt20 PF12090.8 CDI76253.1 - 0.57 9.8 11.5 0.84 9.2 11.5 1.1 1 0 0 1 1 1 0 Spt20 family Macoilin PF09726.9 CDI76256.1 - 1 7.8 28.2 1.2 7.6 28.2 1.0 1 0 0 1 1 1 0 Macoilin family DUF3292 PF11696.8 CDI76256.1 - 3.3 6.0 17.6 3.9 5.7 17.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) TFIIA PF03153.13 CDI76256.1 - 4.9 7.0 44.3 6.1 6.7 44.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 CDI76257.1 - 0.028 14.1 0.0 0.028 14.1 0.0 6.7 4 3 2 7 7 7 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3899 PF13038.6 CDI76257.1 - 0.16 12.4 1.7 0.62 10.6 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) SANT_DAMP1_like PF16282.5 CDI76260.1 - 7.8e-21 74.1 0.5 2.4e-20 72.5 0.5 1.9 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DUF5497 PF17601.2 CDI76260.1 - 0.026 14.8 1.0 0.065 13.6 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5497) Robl_LC7 PF03259.17 CDI76261.1 - 1.2e-23 82.6 0.0 1.4e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 CDI76261.1 - 0.00086 19.2 0.0 0.00094 19.1 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 UPF0176_N PF17773.1 CDI76261.1 - 0.15 12.5 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain Abhydrolase_1 PF00561.20 CDI76262.1 - 1.4e-07 31.5 3.8 0.0014 18.3 0.0 2.6 2 1 1 3 3 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDI76262.1 - 2.7e-06 26.8 1.7 0.013 14.8 0.0 2.6 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DUF818 PF05677.12 CDI76262.1 - 2.4e-05 23.5 0.0 5.6e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 CDI76262.1 - 7.5e-05 22.3 0.4 0.046 13.2 0.0 2.9 3 0 0 3 3 3 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDI76262.1 - 0.0002 21.0 11.1 0.0011 18.6 0.0 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) CCDC53 PF10152.9 CDI76262.1 - 0.00035 21.0 0.6 0.00041 20.8 0.6 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex MecA PF05389.12 CDI76262.1 - 0.0019 17.9 1.6 0.0025 17.5 1.6 1.2 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) DDHD PF02862.17 CDI76262.1 - 0.0034 17.6 3.1 0.0046 17.1 3.1 1.1 1 0 0 1 1 1 1 DDHD domain Ctr PF04145.15 CDI76262.1 - 0.0043 17.7 0.3 0.0059 17.2 0.3 1.2 1 0 0 1 1 1 1 Ctr copper transporter family EIIBC-GUT_N PF03612.14 CDI76262.1 - 0.015 15.0 4.9 0.024 14.4 4.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TMEM51 PF15345.6 CDI76262.1 - 0.039 13.8 10.5 0.055 13.3 10.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Abhydrolase_2 PF02230.16 CDI76262.1 - 0.041 13.7 0.0 0.041 13.7 0.0 1.9 2 1 0 2 2 1 0 Phospholipase/Carboxylesterase DUF4834 PF16118.5 CDI76262.1 - 0.048 14.6 11.0 0.085 13.8 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Baculo_PP31 PF05311.11 CDI76262.1 - 0.056 12.9 3.4 0.071 12.6 3.4 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) CPSF100_C PF13299.6 CDI76262.1 - 0.082 13.1 5.4 0.12 12.6 5.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI76262.1 - 0.11 12.5 2.0 0.15 12.1 2.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 CDI76262.1 - 0.14 11.8 33.1 0.2 11.2 33.1 1.1 1 0 0 1 1 1 0 Spt20 family eIF-3_zeta PF05091.12 CDI76262.1 - 0.14 11.1 10.6 0.19 10.7 10.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CobT PF06213.12 CDI76262.1 - 0.15 11.4 16.7 0.23 10.8 16.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT OATP PF03137.20 CDI76262.1 - 0.17 10.1 2.2 0.23 9.7 2.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BAF250_C PF12031.8 CDI76262.1 - 0.17 11.1 2.7 0.25 10.6 2.7 1.2 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa SID-1_RNA_chan PF13965.6 CDI76262.1 - 0.18 10.2 0.1 0.22 9.9 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 CDI76262.1 - 0.19 10.5 9.4 0.26 10.0 9.4 1.1 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 CDI76262.1 - 0.23 10.4 2.6 0.32 9.9 2.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peroxin-13_N PF04088.13 CDI76262.1 - 0.23 11.7 4.6 0.36 11.1 4.6 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region SpoIIP PF07454.11 CDI76262.1 - 0.23 10.9 10.8 0.34 10.3 10.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) HGTP_anticodon2 PF12745.7 CDI76262.1 - 0.24 10.9 8.4 0.34 10.4 8.4 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DLH PF01738.18 CDI76262.1 - 0.28 10.7 0.0 0.28 10.7 0.0 2.4 2 1 0 2 2 1 0 Dienelactone hydrolase family FAM176 PF14851.6 CDI76262.1 - 0.3 10.8 5.3 0.45 10.2 5.3 1.3 1 0 0 1 1 1 0 FAM176 family V_ATPase_I PF01496.19 CDI76262.1 - 0.32 8.9 8.8 0.42 8.5 8.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI76262.1 - 0.39 9.7 5.9 0.53 9.3 5.9 1.1 1 0 0 1 1 1 0 CLN3 protein Coilin_N PF15862.5 CDI76262.1 - 0.43 10.4 9.9 0.7 9.7 9.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus MPM1 PF17234.2 CDI76262.1 - 0.49 10.6 10.9 0.71 10.1 10.9 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 U1snRNP70_N PF12220.8 CDI76262.1 - 0.72 10.5 12.1 1.1 9.9 12.1 1.2 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal FAM91_C PF14648.6 CDI76262.1 - 0.83 8.4 4.6 1.1 8.0 4.6 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Connexin PF00029.19 CDI76262.1 - 1 9.0 7.0 1.6 8.4 7.0 1.2 1 0 0 1 1 1 0 Connexin TERB2 PF15101.6 CDI76262.1 - 1.2 9.2 16.3 1.9 8.5 16.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 BRF1 PF07741.13 CDI76262.1 - 1.2 9.5 10.7 1.9 8.9 10.7 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain GNAT_acetyltr_2 PF13718.6 CDI76262.1 - 1.3 8.3 7.1 2 7.8 7.1 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CSG2 PF16965.5 CDI76262.1 - 1.4 7.8 3.5 1.9 7.3 3.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Rpp20 PF12328.8 CDI76262.1 - 1.5 8.8 12.0 2.5 8.1 12.0 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P ABC2_membrane_2 PF12679.7 CDI76262.1 - 1.9 7.7 5.5 2.8 7.2 5.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF2828 PF11443.8 CDI76262.1 - 2 6.4 8.3 2.7 6.0 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TFIIA PF03153.13 CDI76262.1 - 2.1 8.3 29.3 2.8 7.9 29.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sec62 PF03839.16 CDI76262.1 - 2.3 7.7 7.7 3.3 7.2 7.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4820 PF16091.5 CDI76262.1 - 2.9 7.2 10.1 4.3 6.6 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Eapp_C PF10238.9 CDI76262.1 - 2.9 8.0 12.6 4.6 7.3 12.6 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF3405 PF11885.8 CDI76262.1 - 3.3 6.2 9.6 4.4 5.8 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Band_3_cyto PF07565.13 CDI76262.1 - 3.4 7.4 8.7 4.8 6.9 8.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2681 PF10883.8 CDI76262.1 - 3.4 8.1 23.4 6.3 7.3 23.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) MDM10 PF12519.8 CDI76262.1 - 3.7 6.3 6.6 5 5.9 6.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TFB6 PF17110.5 CDI76262.1 - 3.7 7.3 7.8 5.7 6.7 7.8 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH HemX PF04375.14 CDI76262.1 - 3.8 6.7 23.4 5.1 6.3 23.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF1980 PF09323.10 CDI76262.1 - 3.9 7.3 6.6 5.9 6.8 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) AIF_C PF14721.6 CDI76262.1 - 4.2 7.7 8.6 6.7 7.1 8.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ALMT PF11744.8 CDI76262.1 - 4.5 6.0 6.2 6.8 5.4 6.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Folate_carrier PF01770.18 CDI76262.1 - 4.7 5.8 5.3 7.3 5.2 5.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier PIP5K PF01504.18 CDI76262.1 - 4.7 6.3 8.3 6.6 5.9 8.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Paf1 PF03985.13 CDI76262.1 - 4.9 6.0 15.6 6.8 5.6 15.6 1.1 1 0 0 1 1 1 0 Paf1 DUF5308 PF17233.2 CDI76262.1 - 5.6 7.2 13.0 17 5.6 13.0 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5308) MDM31_MDM32 PF08118.11 CDI76262.1 - 6 5.4 7.7 7.9 5.0 7.7 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Folliculin PF11704.8 CDI76262.1 - 7.3 6.4 9.3 14 5.5 9.3 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport FAM150 PF15129.6 CDI76262.1 - 7.6 6.7 11.6 13 5.9 11.6 1.3 1 0 0 1 1 1 0 FAM150 family MMR1 PF08505.10 CDI76262.1 - 8.5 6.6 14.6 12 6.1 14.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_C50 PF03568.17 CDI76262.1 - 9.1 5.3 11.3 0.6 9.2 0.2 2.1 2 0 0 2 2 2 0 Peptidase family C50 Kei1 PF08552.11 CDI76262.1 - 9.5 6.1 7.0 14 5.5 7.0 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4746 PF15928.5 CDI76262.1 - 9.7 5.5 10.6 16 4.8 10.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Endonuclease_NS PF01223.23 CDI76263.1 - 1.3e-17 64.4 0.0 6.6e-17 62.1 0.0 1.9 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease RRM_1 PF00076.22 CDI76264.1 - 0.033 14.0 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNase PF00565.17 CDI76265.1 - 6.7e-09 36.2 0.0 0.00014 22.3 0.0 2.6 2 0 0 2 2 2 2 Staphylococcal nuclease homologue TFIIA PF03153.13 CDI76265.1 - 0.0052 16.8 10.7 0.012 15.6 10.7 1.7 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI76265.1 - 0.15 11.6 2.4 0.24 10.9 2.4 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Rhodanese PF00581.20 CDI76266.1 - 3.2e-16 59.8 0.0 5.2e-05 23.7 0.0 3.6 3 1 0 3 3 3 3 Rhodanese-like domain DUF2722 PF10846.8 CDI76266.1 - 3.8e-05 22.8 11.7 0.02 13.8 0.0 3.6 2 1 1 3 3 3 2 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI76266.1 - 0.0011 17.8 4.1 0.0011 17.8 4.1 2.3 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal Secretin_N_2 PF07655.13 CDI76266.1 - 0.014 15.9 2.0 0.014 15.9 2.0 2.8 4 0 0 4 4 4 0 Secretin N-terminal domain ARF7EP_C PF14949.6 CDI76266.1 - 0.88 10.2 4.7 9.1 6.9 0.3 2.7 2 0 0 2 2 2 0 ARF7 effector protein C-terminus FAM60A PF15396.6 CDI76266.1 - 0.91 9.5 6.0 0.98 9.4 2.0 2.4 2 1 0 2 2 2 0 Protein Family FAM60A TFIIA PF03153.13 CDI76267.1 - 0.097 12.6 31.1 0.21 11.5 28.7 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pal1 PF08316.11 CDI76267.1 - 0.12 13.2 2.6 22 5.8 2.4 2.5 2 0 0 2 2 2 0 Pal1 cell morphology protein PNISR PF15996.5 CDI76267.1 - 0.17 12.1 19.5 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Lin-8 PF03353.15 CDI76267.1 - 0.73 9.3 16.2 0.44 10.0 13.8 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist RabGAP-TBC PF00566.18 CDI76268.1 - 1.8e-05 24.5 0.1 1.8e-05 24.5 0.1 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Presenilin PF01080.17 CDI76268.1 - 0.0073 15.1 4.8 0.0081 15.0 4.8 1.1 1 0 0 1 1 1 1 Presenilin TFIIA PF03153.13 CDI76268.1 - 0.0081 16.2 15.5 0.0089 16.1 15.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF755 PF05501.11 CDI76268.1 - 0.04 14.2 19.2 0.065 13.5 19.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) O-antigen_lig PF13425.6 CDI76268.1 - 0.11 11.2 1.1 0.13 11.0 1.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Miga PF10265.9 CDI76268.1 - 0.14 11.1 8.8 0.18 10.7 8.8 1.1 1 0 0 1 1 1 0 Mitoguardin BORG_CEP PF14957.6 CDI76268.1 - 0.3 12.3 5.7 0.45 11.7 5.7 1.3 1 0 0 1 1 1 0 Cdc42 effector G0-G1_switch_2 PF15103.6 CDI76268.1 - 0.35 11.3 9.7 3.1 8.3 9.7 2.3 1 1 0 1 1 1 0 G0/G1 switch protein 2 Ndc1_Nup PF09531.10 CDI76268.1 - 0.37 9.4 5.0 0.4 9.3 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Androgen_recep PF02166.16 CDI76268.1 - 0.39 9.5 17.8 0.55 9.0 17.8 1.2 1 0 0 1 1 1 0 Androgen receptor SLC12 PF03522.15 CDI76268.1 - 0.84 8.6 9.6 1.1 8.2 9.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Spt20 PF12090.8 CDI76268.1 - 1 8.9 24.9 1.4 8.4 24.9 1.2 1 0 0 1 1 1 0 Spt20 family RR_TM4-6 PF06459.12 CDI76268.1 - 1.2 8.9 8.1 1.7 8.4 8.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI76268.1 - 1.5 7.0 16.5 2 6.6 16.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI76268.1 - 1.8 5.6 11.1 2.2 5.3 11.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CLN3 PF02487.17 CDI76268.1 - 3.5 6.6 4.5 4.5 6.2 4.5 1.2 1 0 0 1 1 1 0 CLN3 protein Hid1 PF12722.7 CDI76268.1 - 5.1 5.1 14.7 6.4 4.8 14.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DDRGK PF09756.9 CDI76268.1 - 7.1 6.2 17.0 10 5.7 17.0 1.2 1 0 0 1 1 1 0 DDRGK domain PIEZO PF15917.5 CDI76269.1 - 0.033 13.7 0.1 0.054 13.0 0.1 1.3 1 0 0 1 1 1 0 Piezo RAB3GAP2_N PF14655.6 CDI76269.1 - 0.11 11.7 2.1 0.16 11.2 2.1 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus AIRS_C PF02769.22 CDI76271.1 - 3.5e-16 59.7 4.0 1.6e-11 44.6 2.9 2.7 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDI76271.1 - 1e-11 45.3 1.1 5e-11 43.1 0.1 2.8 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Pyr_redox_2 PF07992.14 CDI76271.1 - 1.2e-11 44.4 0.1 1.2e-11 44.4 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDI76271.1 - 3.3e-07 30.8 0.4 0.037 14.6 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI76271.1 - 0.14 11.4 0.1 0.24 10.6 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ORC6 PF05460.13 CDI76272.1 - 8.3 5.6 11.3 8.9 5.5 11.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Spt20 PF12090.8 CDI76273.1 - 0.17 11.5 12.8 2.2 7.9 0.4 2.2 2 0 0 2 2 2 0 Spt20 family Cons_hypoth95 PF03602.15 CDI76274.1 - 4.7e-29 101.3 0.1 1.2e-24 86.9 0.0 3.0 2 1 1 3 3 3 2 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CDI76274.1 - 9.2e-05 22.3 0.0 0.0002 21.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI76274.1 - 0.002 18.8 0.1 0.0089 16.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDI76274.1 - 0.0028 17.2 0.1 0.03 13.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 CDI76274.1 - 0.047 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 CDI76274.1 - 0.077 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.6 CDI76274.1 - 0.14 12.0 1.0 0.34 10.7 1.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain LLGL PF08366.13 CDI76274.1 - 0.24 11.7 0.1 0.61 10.5 0.1 1.6 1 0 0 1 1 1 0 LLGL2 SAPS PF04499.15 CDI76274.1 - 0.54 9.0 5.7 39 2.9 0.0 2.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Inositol_P PF00459.25 CDI76275.1 - 2.4e-13 50.2 7.0 0.00047 19.8 0.1 4.6 3 2 1 4 4 4 3 Inositol monophosphatase family DDHD PF02862.17 CDI76275.1 - 0.2 11.8 8.2 2.6 8.1 1.0 2.8 3 0 0 3 3 3 0 DDHD domain Hist_deacetyl PF00850.19 CDI76275.1 - 0.38 10.2 4.7 0.24 10.8 2.0 2.1 2 1 0 2 2 2 0 Histone deacetylase domain DUF4834 PF16118.5 CDI76275.1 - 1.2 10.2 22.6 0.17 12.9 2.8 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SpoIIP PF07454.11 CDI76275.1 - 1.8 8.0 13.9 0.96 8.9 0.5 2.4 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) CNDH2_M PF16869.5 CDI76275.1 - 2.4 8.9 14.3 21 5.8 1.2 3.6 3 0 0 3 3 3 0 PF16858 Lin-8 PF03353.15 CDI76275.1 - 2.4 7.6 17.3 1.6 8.3 5.1 2.4 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI76275.1 - 2.4 6.3 25.2 0.86 7.8 7.8 2.4 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.13 CDI76275.1 - 2.5 8.7 35.0 0.039 14.6 7.8 4.5 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1980 PF09323.10 CDI76275.1 - 3.3 7.6 9.6 1.5 8.7 1.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF3801 PF12687.7 CDI76275.1 - 4.3 7.4 14.3 3.5 7.7 2.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3801) Ctr PF04145.15 CDI76275.1 - 4.5 7.9 7.7 9.5 6.8 0.4 2.8 2 0 0 2 2 2 0 Ctr copper transporter family Presenilin PF01080.17 CDI76275.1 - 5.1 5.8 19.4 1.5 7.5 4.6 2.6 3 0 0 3 3 3 0 Presenilin SR-25 PF10500.9 CDI76276.1 - 0.0027 17.4 22.8 0.0027 17.4 22.8 2.2 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein PAT1 PF09770.9 CDI76276.1 - 0.013 13.8 39.3 0.014 13.8 39.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF572 PF04502.13 CDI76276.1 - 0.17 11.5 36.0 0.21 11.2 36.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop14 PF04147.12 CDI76276.1 - 2 6.5 40.9 2.7 6.1 40.9 1.2 1 0 0 1 1 1 0 Nop14-like family AF-4 PF05110.13 CDI76276.1 - 2.6 6.0 50.0 3.5 5.6 50.0 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RRM_1 PF00076.22 CDI76277.1 - 1.3e-12 47.4 0.1 5.1e-12 45.4 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI76277.1 - 0.00097 19.2 0.0 0.0091 16.1 0.0 2.9 1 1 0 1 1 1 1 RNA recognition motif Adaptin_N PF01602.20 CDI76278.1 - 4.4e-16 58.5 2.1 2.3e-09 36.4 0.2 3.6 2 1 2 4 4 4 3 Adaptin N terminal region Cnd1 PF12717.7 CDI76278.1 - 6.5e-15 55.5 1.1 1.7e-10 41.2 0.1 2.8 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 CDI76278.1 - 8.4e-09 35.5 1.0 1.5e-08 34.7 1.0 1.4 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain SUIM_assoc PF16619.5 CDI76278.1 - 0.0038 17.3 0.6 0.0065 16.5 0.6 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Phostensin_N PF13916.6 CDI76278.1 - 0.052 13.9 2.8 0.1 13.0 2.8 1.4 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Ofd1_CTDD PF10637.9 CDI76278.1 - 0.072 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Coq4 PF05019.13 CDI76279.1 - 8.9e-47 159.3 0.0 1.1e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Adeno_PIX PF03955.14 CDI76279.1 - 0.083 13.1 5.8 0.15 12.2 5.8 1.4 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) PAT1 PF09770.9 CDI76281.1 - 0.61 8.3 28.8 0.78 7.9 28.8 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2298 PF10060.9 CDI76281.1 - 0.72 8.5 3.0 1.3 7.6 3.0 1.4 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Serinc PF03348.15 CDI76281.1 - 2.5 6.9 9.1 3.4 6.5 9.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) EOS1 PF12326.8 CDI76281.1 - 3.2 7.6 4.9 5 7.0 4.9 1.3 1 0 0 1 1 1 0 N-glycosylation protein BAF1_ABF1 PF04684.13 CDI76281.1 - 3.3 6.6 17.8 7.1 5.6 17.8 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Presenilin PF01080.17 CDI76281.1 - 5.9 5.5 19.6 8 5.1 19.6 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI76281.1 - 6 6.6 16.5 10 5.9 16.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RAP PF08373.10 CDI76283.1 - 9.3e-22 76.9 0.1 2.9e-21 75.3 0.1 1.9 1 0 0 1 1 1 1 RAP domain SR-25 PF10500.9 CDI76283.1 - 3.6 7.1 39.4 0.048 13.3 6.3 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Anticodon_1 PF08264.13 CDI76285.1 - 3.5e-14 53.0 0.1 5.6e-14 52.4 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Suf PF05843.14 CDI76285.1 - 0.066 13.2 1.8 0.1 12.6 1.8 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) tRNA-synt_1e PF01406.19 CDI76285.1 - 0.07 12.5 0.0 0.24 10.7 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain LIAS_N PF16881.5 CDI76285.1 - 0.11 12.9 0.9 1.5 9.2 0.2 2.4 1 1 1 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family RP853 PF17542.2 CDI76285.1 - 0.16 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized RP853 tRNA-synt_1 PF00133.22 CDI76286.1 - 2.7e-07 29.2 0.0 4.7e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Pterin_bind PF00809.22 CDI76287.1 - 1.9e-67 227.5 0.0 3.2e-67 226.8 0.0 1.3 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 CDI76287.1 - 1.2e-24 87.0 0.1 3.7e-24 85.4 0.1 1.9 1 1 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) N1221 PF07923.13 CDI76287.1 - 0.04 13.1 0.1 0.068 12.3 0.1 1.3 1 0 0 1 1 1 0 N1221-like protein PEP_mutase PF13714.6 CDI76287.1 - 0.055 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase ClpS PF02617.17 CDI76289.1 - 3.5e-11 42.7 0.2 3.5e-11 42.7 0.2 1.8 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS cNMP_binding PF00027.29 CDI76290.1 - 5.9e-13 48.7 0.0 0.00015 21.8 0.0 3.6 1 1 1 2 2 2 2 Cyclic nucleotide-binding domain KIF1B PF12423.8 CDI76290.1 - 0.067 13.6 0.0 0.27 11.7 0.0 2.1 1 0 0 1 1 1 0 Kinesin protein 1B AAA_23 PF13476.6 CDI76290.1 - 0.82 10.1 20.7 0.19 12.2 3.0 2.9 3 0 0 3 3 3 0 AAA domain FapA PF03961.13 CDI76290.1 - 5.4 5.5 21.3 0.45 9.1 4.1 2.7 3 0 0 3 3 3 0 Flagellar Assembly Protein A DUF3458_C PF17432.2 CDI76292.1 - 2.2e-100 336.2 7.5 3.9e-100 335.3 7.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 CDI76292.1 - 9.5e-50 169.2 0.8 1.6e-49 168.4 0.8 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 CDI76292.1 - 3.7e-25 88.2 0.0 8.3e-25 87.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 CDI76292.1 - 4.5e-13 49.8 0.0 1.6e-12 48.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 CDI76292.1 - 0.023 15.1 0.2 0.2 12.1 0.2 2.3 1 1 0 1 1 1 0 M61 glycyl aminopeptidase zf-DNL PF05180.12 CDI76295.1 - 8e-28 96.2 0.6 1.2e-27 95.7 0.6 1.2 1 0 0 1 1 1 1 DNL zinc finger zf-CSL PF05207.13 CDI76295.1 - 0.064 13.0 0.4 0.13 12.0 0.4 1.5 1 0 0 1 1 1 0 CSL zinc finger TFIIS_C PF01096.18 CDI76295.1 - 0.1 12.4 3.6 0.18 11.7 0.8 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Methyltransf_11 PF08241.12 CDI76296.1 - 8.4e-07 29.6 0.0 3.9e-06 27.4 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI76296.1 - 0.0002 22.0 0.0 0.00047 20.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI76296.1 - 0.00028 21.6 0.0 0.00088 20.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI76296.1 - 0.0021 17.9 0.1 0.0027 17.6 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CDI76296.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family RRM_1 PF00076.22 CDI76298.1 - 1.3e-15 56.9 0.0 1.9e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.13 CDI76298.1 - 6e-11 42.5 0.0 2.7e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 SPOC domain RRM_occluded PF16842.5 CDI76298.1 - 0.021 14.7 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif SET_assoc PF11767.8 CDI76298.1 - 0.049 13.3 0.2 0.082 12.6 0.2 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 CDI76298.1 - 0.21 11.6 0.6 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Leo1 PF04004.13 CDI76300.1 - 1.1e-06 28.5 0.0 2.8e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 Leo1-like protein SUIM_assoc PF16619.5 CDI76300.1 - 0.025 14.6 6.6 0.061 13.4 6.6 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TMEM51 PF15345.6 CDI76300.1 - 4.6 7.0 8.5 0.68 9.7 0.3 2.4 2 1 0 2 2 2 0 Transmembrane protein 51 DUF2052 PF09747.9 CDI76301.1 - 0.59 10.2 27.5 0.73 9.9 27.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 CDI76301.1 - 0.8 9.5 27.7 0.95 9.2 27.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI76301.1 - 1.2 7.8 34.0 1.3 7.7 34.0 1.1 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 CDI76301.1 - 1.5 8.9 30.8 1.7 8.7 30.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC45 PF02724.14 CDI76301.1 - 2 6.6 28.0 2.2 6.5 28.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 CDI76301.1 - 4.5 6.4 26.4 5 6.2 26.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Asp-B-Hydro_N PF05279.11 CDI76301.1 - 4.9 7.2 23.1 5.6 7.0 23.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF913 PF06025.12 CDI76301.1 - 6 5.7 17.6 7.9 5.3 17.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 CDI76301.1 - 6.8 6.0 20.0 9.7 5.5 20.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PNISR PF15996.5 CDI76301.1 - 7.4 6.8 32.9 8.1 6.7 32.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Neur_chan_memb PF02932.16 CDI76301.1 - 8.7 6.3 23.3 11 6.0 23.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI76301.1 - 9.9 4.4 16.0 11 4.3 16.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MAD PF05557.13 CDI76302.1 - 0.00086 17.8 37.1 0.00086 17.8 37.1 2.4 2 0 0 2 2 2 1 Mitotic checkpoint protein CENP-F_leu_zip PF10473.9 CDI76302.1 - 0.0029 17.6 14.3 0.0029 17.6 14.3 5.0 3 1 0 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 CDI76302.1 - 0.0046 17.0 22.2 0.011 15.8 0.2 4.4 2 2 2 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_GP20 PF06810.11 CDI76302.1 - 0.006 16.4 12.1 0.006 16.4 12.1 6.5 2 2 4 6 6 6 2 Phage minor structural protein GP20 HALZ PF02183.18 CDI76302.1 - 0.0093 16.2 1.8 0.0093 16.2 1.8 5.5 7 0 0 7 7 6 1 Homeobox associated leucine zipper FH2 PF02181.23 CDI76302.1 - 0.44 9.6 37.0 0.14 11.2 5.9 3.6 2 2 1 3 3 3 0 Formin Homology 2 Domain ApoO PF09769.9 CDI76302.1 - 1.3 9.0 14.0 3.1 7.8 1.1 4.0 2 2 2 4 4 4 0 Apolipoprotein O FlaC_arch PF05377.11 CDI76302.1 - 2.8 8.4 39.0 0.15 12.5 1.2 6.4 6 2 1 7 7 7 0 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.11 CDI76302.1 - 3.9 6.2 62.3 0.74 8.6 38.2 3.0 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Filament PF00038.21 CDI76302.1 - 6.6 6.2 67.6 2.3 7.7 42.3 2.7 2 1 1 3 3 3 0 Intermediate filament protein BLOC1_2 PF10046.9 CDI76302.1 - 7.9 6.9 46.3 0.32 11.3 10.7 5.5 4 3 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HEAT_2 PF13646.6 CDI76304.1 - 6.3e-08 32.9 9.9 1.8e-05 25.0 0.5 5.5 2 2 3 5 5 5 2 HEAT repeats HEAT_PBS PF03130.16 CDI76304.1 - 2.6e-05 24.5 30.5 0.28 12.0 0.0 7.9 6 1 0 6 6 6 3 PBS lyase HEAT-like repeat HEAT PF02985.22 CDI76304.1 - 0.001 19.1 8.6 7.1 7.2 0.0 6.2 5 1 0 5 5 5 2 HEAT repeat Cohesin_HEAT PF12765.7 CDI76304.1 - 0.031 14.6 0.2 0.53 10.6 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 CDI76304.1 - 0.036 14.1 1.1 0.34 10.9 0.1 2.9 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RNA_polI_A14 PF08203.11 CDI76304.1 - 2.1 9.1 4.1 2.9 8.7 0.0 3.2 4 0 0 4 4 4 0 Yeast RNA polymerase I subunit RPA14 Pex16 PF08610.10 CDI76306.1 - 2.7e-32 112.2 0.3 5.7e-32 111.2 0.3 1.4 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) TFIIA PF03153.13 CDI76306.1 - 0.19 11.7 9.1 0.32 11.0 9.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PARP PF00644.20 CDI76307.1 - 4.8e-11 42.6 0.0 4.3e-06 26.5 0.0 2.6 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain MA3 PF02847.17 CDI76308.1 - 3.8e-29 100.9 1.6 1.2e-09 38.1 0.0 3.2 3 0 0 3 3 3 3 MA3 domain Lipase_3 PF01764.25 CDI76310.1 - 1.8e-16 60.3 0.0 3e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CDI76310.1 - 0.0019 17.5 0.0 0.0041 16.4 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Cutinase PF01083.22 CDI76310.1 - 0.087 12.8 0.0 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Cutinase CutA1 PF03091.15 CDI76311.1 - 2.3e-35 120.4 1.3 2.8e-35 120.1 1.3 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein SseB_C PF14581.6 CDI76311.1 - 0.0019 18.3 0.1 0.0023 18.0 0.1 1.2 1 0 0 1 1 1 1 SseB protein C-terminal domain DZF PF07528.14 CDI76311.1 - 0.0049 16.5 0.3 0.0059 16.3 0.3 1.1 1 0 0 1 1 1 1 DZF domain AAT PF03417.16 CDI76311.1 - 0.0059 16.3 0.0 0.0068 16.1 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Arg_repressor_C PF02863.18 CDI76311.1 - 0.067 13.1 0.2 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Arginine repressor, C-terminal domain AsnC_trans_reg PF01037.21 CDI76311.1 - 0.11 12.5 0.4 0.48 10.4 0.1 1.9 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain DUF1514 PF07438.11 CDI76311.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) vATP-synt_E PF01991.18 CDI76312.1 - 7.1e-58 195.3 1.6 8.8e-58 195.0 1.6 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4239 PF14023.6 CDI76312.1 - 0.0084 15.9 5.2 0.031 14.0 4.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4239) IL13 PF03487.13 CDI76312.1 - 0.045 13.5 1.6 0.065 13.0 0.5 1.8 2 0 0 2 2 2 0 Interleukin-13 Helicase_PWI PF18149.1 CDI76312.1 - 0.048 13.8 5.3 0.042 14.0 3.5 1.7 2 0 0 2 2 2 0 N-terminal helicase PWI domain CemA PF03040.14 CDI76312.1 - 0.94 9.4 6.1 1.4 8.8 5.8 1.4 1 1 0 1 1 1 0 CemA family PDCD2_C PF04194.13 CDI76313.1 - 5.6e-36 124.2 0.1 8.7e-36 123.6 0.1 1.4 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Lar_restr_allev PF14354.6 CDI76313.1 - 0.02 15.3 0.2 0.02 15.3 0.2 2.6 3 1 0 3 3 3 0 Restriction alleviation protein Lar Kelch_3 PF13415.6 CDI76314.1 - 2.9e-17 62.5 1.8 5.2e-07 29.8 0.1 5.2 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI76314.1 - 1.5e-16 60.0 0.6 0.0036 17.3 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 CDI76314.1 - 3.5e-14 52.5 5.1 9.6e-06 25.5 0.0 5.7 4 1 1 5 5 5 3 Galactose oxidase, central domain HATPase_c_3 PF13589.6 CDI76314.1 - 1.5e-09 37.8 0.0 2.9e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_1 PF01344.25 CDI76314.1 - 5.6e-05 22.6 0.3 1.9 8.1 0.0 4.1 4 0 0 4 4 4 2 Kelch motif HATPase_c PF02518.26 CDI76314.1 - 0.00011 22.7 0.0 0.00027 21.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_6 PF13964.6 CDI76314.1 - 0.0015 18.7 3.1 0.092 13.1 0.1 4.1 2 2 3 5 5 5 1 Kelch motif Ribosomal_S3Ae PF01015.18 CDI76315.1 - 5.4e-90 300.4 0.1 6.6e-90 300.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 CDI76315.1 - 0.19 11.3 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Kelch_4 PF13418.6 CDI76318.1 - 1.4e-35 121.0 8.5 1e-08 35.0 0.0 7.0 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI76318.1 - 1.3e-26 92.1 4.7 3.9e-06 26.7 0.2 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 CDI76318.1 - 5.3e-25 86.8 2.6 1.5e-06 28.3 0.3 5.5 4 1 1 5 5 5 5 Kelch motif Kelch_3 PF13415.6 CDI76318.1 - 8.4e-25 86.5 8.4 1.9e-07 31.2 0.0 7.8 9 0 0 9 9 9 4 Galactose oxidase, central domain DUF4110 PF13422.6 CDI76318.1 - 2.4e-18 66.0 0.4 2.4e-18 66.0 0.4 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4110) Kelch_1 PF01344.25 CDI76318.1 - 1.2e-15 56.8 10.9 7.5e-05 22.2 0.1 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 CDI76318.1 - 6.7e-12 44.9 19.0 3.6e-05 23.5 0.1 6.9 6 2 0 6 6 6 4 Kelch motif PIEZO PF15917.5 CDI76318.1 - 0.14 11.6 2.7 0.38 10.2 2.7 1.7 1 0 0 1 1 1 0 Piezo CUE PF02845.16 CDI76319.1 - 0.012 15.3 0.0 0.033 13.9 0.0 1.7 1 0 0 1 1 1 0 CUE domain CS PF04969.16 CDI76320.1 - 0.00086 20.3 0.0 0.0014 19.6 0.0 1.3 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.11 CDI76320.1 - 0.015 15.6 0.1 0.031 14.6 0.1 1.6 1 0 0 1 1 1 0 Siah interacting protein, N terminal Ribosomal_S19 PF00203.21 CDI76321.1 - 2.4e-30 104.2 0.1 3.2e-30 103.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 DUF4381 PF14316.6 CDI76322.1 - 0.046 14.0 2.4 0.074 13.3 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) LRR_4 PF12799.7 CDI76323.1 - 9.1e-22 76.8 19.6 3.3e-07 30.5 3.0 5.5 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDI76323.1 - 6.1e-16 58.4 4.3 5e-06 26.1 0.0 2.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 CDI76323.1 - 2.7e-13 49.5 12.1 1.4e-07 31.2 1.4 4.6 1 1 3 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 CDI76323.1 - 2.1e-05 24.2 13.5 0.42 10.8 0.0 5.9 5 1 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 CDI76323.1 - 3.7e-05 23.7 15.8 4.6 8.2 0.0 7.1 4 1 2 6 6 6 2 Leucine Rich Repeat Surp PF01805.20 CDI76324.1 - 5.4e-09 35.9 0.1 1.3e-08 34.7 0.1 1.7 1 0 0 1 1 1 1 Surp module DRY_EERY PF09750.9 CDI76324.1 - 2.3e-08 34.4 0.8 2.3e-08 34.4 0.8 4.1 4 0 0 4 4 4 1 Alternative splicing regulator SHS2_Rpb7-N PF03876.17 CDI76325.1 - 6.3e-13 48.9 0.1 1e-12 48.2 0.1 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CDI76325.1 - 3.6e-07 30.4 0.0 6.6e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 CDI76325.1 - 0.096 12.9 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 polyprenyl_synt PF00348.17 CDI76326.1 - 6.6e-53 179.4 0.3 1.6e-30 106.1 0.2 3.6 3 1 0 3 3 3 3 Polyprenyl synthetase adh_short PF00106.25 CDI76328.1 - 4.1e-21 75.3 0.0 2.5e-18 66.3 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDI76328.1 - 1.8e-13 50.6 0.0 1.7e-12 47.4 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDI76328.1 - 1.4e-06 28.3 0.0 3.9e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 KR domain RimM PF01782.18 CDI76328.1 - 0.067 13.4 0.0 6.3 7.1 0.0 2.4 2 0 0 2 2 2 0 RimM N-terminal domain B-block_TFIIIC PF04182.12 CDI76329.1 - 4.6e-08 33.1 0.0 3.5e-07 30.3 0.0 2.3 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC DUF2681 PF10883.8 CDI76332.1 - 0.0019 18.6 4.3 0.006 17.0 4.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) FAM176 PF14851.6 CDI76332.1 - 0.0096 15.6 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 FAM176 family TNFR_16_TM PF18422.1 CDI76332.1 - 0.066 13.2 0.1 0.066 13.2 0.1 1.8 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain LapA_dom PF06305.11 CDI76332.1 - 0.32 10.9 2.3 0.68 9.8 2.3 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain HSP70 PF00012.20 CDI76334.1 - 8.5e-98 328.1 8.3 1.1e-97 327.7 8.3 1.1 1 0 0 1 1 1 1 Hsp70 protein Mod_r PF07200.13 CDI76334.1 - 0.017 15.3 11.7 0.042 13.9 11.7 1.6 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Tetraspanin PF00335.20 CDI76334.1 - 0.017 14.9 1.1 0.023 14.4 1.1 1.2 1 0 0 1 1 1 0 Tetraspanin family Seryl_tRNA_N PF02403.22 CDI76334.1 - 0.021 15.0 13.7 0.06 13.6 13.7 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HBS1_N PF08938.10 CDI76334.1 - 0.049 13.9 4.8 0.1 12.9 4.8 1.6 1 0 0 1 1 1 0 HBS1 N-terminus GBP_C PF02841.14 CDI76334.1 - 0.077 12.4 15.0 0.19 11.1 15.0 1.7 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Piezo_RRas_bdg PF12166.8 CDI76334.1 - 0.28 10.4 6.0 0.34 10.1 6.0 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DUF572 PF04502.13 CDI76334.1 - 0.63 9.6 16.9 0.91 9.1 16.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.9 CDI76334.1 - 0.85 8.1 21.3 1.4 7.4 21.3 1.3 1 0 0 1 1 1 0 Macoilin family TAF4 PF05236.14 CDI76334.1 - 2.3 7.9 24.0 0.042 13.6 15.3 2.1 1 1 2 3 3 3 0 Transcription initiation factor TFIID component TAF4 family Secretin_N_2 PF07655.13 CDI76334.1 - 2.4 8.7 21.7 7.3 7.2 21.7 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3439 PF11921.8 CDI76334.1 - 7.4 6.6 9.6 19 5.3 9.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Borrelia_P83 PF05262.11 CDI76336.1 - 0.00015 20.5 8.8 0.00017 20.3 8.8 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein DUF2828 PF11443.8 CDI76336.1 - 0.0061 14.7 7.6 0.0064 14.6 7.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) RskA PF10099.9 CDI76336.1 - 0.007 16.7 5.0 0.007 16.7 5.0 2.5 2 1 1 3 3 3 1 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI76336.1 - 0.022 13.2 0.0 0.023 13.2 0.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BORG_CEP PF14957.6 CDI76336.1 - 0.074 14.2 11.0 0.13 13.4 11.0 1.4 1 0 0 1 1 1 0 Cdc42 effector Shadoo PF14999.6 CDI76336.1 - 0.16 12.1 11.1 0.33 11.0 11.1 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective TFIIA PF03153.13 CDI76336.1 - 1.6 8.7 38.8 2.2 8.2 38.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1980 PF09323.10 CDI76336.1 - 5.7 6.8 15.8 73 3.2 15.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) Pex14_N PF04695.13 CDI76336.1 - 6.4 7.4 24.6 12 6.5 24.6 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMR1 PF08505.10 CDI76336.1 - 6.8 6.9 24.0 9.5 6.4 24.0 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein zf-C2HC_2 PF13913.6 CDI76337.1 - 1e-08 34.9 19.8 5.7e-06 26.1 7.1 2.6 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Transposase_21 PF02992.14 CDI76337.1 - 1.1 8.5 5.9 3.7 6.7 5.9 2.0 1 0 0 1 1 1 0 Transposase family tnp2 Mito_carr PF00153.27 CDI76338.1 - 0.00012 22.0 18.9 0.028 14.3 0.1 4.8 5 1 0 5 5 5 3 Mitochondrial carrier protein Spt20 PF12090.8 CDI76338.1 - 0.79 9.3 25.5 1.4 8.5 16.7 2.2 2 0 0 2 2 2 0 Spt20 family Kinesin PF00225.23 CDI76339.1 - 3.7e-50 170.7 0.2 3.7e-50 170.7 0.2 4.9 2 1 1 3 3 3 1 Kinesin motor domain FHA PF00498.26 CDI76339.1 - 3.9e-07 30.3 0.0 1e-06 29.0 0.0 1.8 1 0 0 1 1 1 1 FHA domain Kinesin_assoc PF16183.5 CDI76339.1 - 2.8e-06 27.6 0.1 2.8e-06 27.6 0.1 6.8 3 2 3 6 6 6 1 Kinesin-associated Ribosomal_60s PF00428.19 CDI76339.1 - 0.015 15.9 6.3 0.015 15.9 6.3 9.3 7 1 1 8 8 8 0 60s Acidic ribosomal protein SR-25 PF10500.9 CDI76340.1 - 0.0056 16.3 29.7 0.21 11.2 6.4 2.3 2 1 0 2 2 2 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI76340.1 - 0.006 16.9 17.8 0.042 14.1 17.8 2.1 1 1 0 1 1 1 1 Anti-sigma-K factor rskA DUF4407 PF14362.6 CDI76340.1 - 0.098 12.0 10.1 0.94 8.8 3.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 CDI76340.1 - 0.12 12.3 23.3 0.15 12.0 23.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCSAP PF15748.5 CDI76340.1 - 0.13 12.4 12.1 0.091 12.9 5.3 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated MCU PF04678.13 CDI76340.1 - 0.93 9.6 6.7 3.6 7.6 2.8 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter CPSF100_C PF13299.6 CDI76340.1 - 2.4 8.3 8.3 5.2 7.2 0.5 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal eIF3_subunit PF08597.10 CDI76340.1 - 4.5 7.1 12.0 9.6 6.0 4.4 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit IMUP PF15761.5 CDI76340.1 - 5.1 7.8 28.4 1.2 9.9 9.0 2.5 2 1 0 2 2 2 0 Immortalisation up-regulated protein Peptidase_S64 PF08192.11 CDI76340.1 - 5.6 5.3 15.1 7 5.0 15.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 BRF1 PF07741.13 CDI76340.1 - 8.9 6.7 12.8 3 8.2 1.4 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Peptidase_M48_N PF16491.5 CDI76342.1 - 3.7e-53 180.1 0.3 8.8e-53 178.9 0.0 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CDI76342.1 - 1.9e-41 142.0 0.0 1.9e-40 138.7 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M48 ATP_bind_1 PF03029.17 CDI76344.1 - 0.00026 20.8 5.5 0.022 14.6 0.8 3.2 2 1 2 4 4 4 2 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 CDI76344.1 - 0.00081 19.8 0.1 0.00081 19.8 0.1 2.7 3 0 0 3 3 2 1 AAA ATPase domain AAA_23 PF13476.6 CDI76344.1 - 0.0015 19.0 7.1 0.0036 17.8 7.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDI76344.1 - 0.0027 17.5 0.4 0.0027 17.5 0.4 3.4 2 2 2 4 4 1 1 AAA domain AAA_18 PF13238.6 CDI76344.1 - 0.0044 17.6 0.7 0.0099 16.4 0.1 1.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDI76344.1 - 0.0045 16.3 0.1 0.0099 15.2 0.1 1.5 1 0 0 1 1 1 1 Zeta toxin NB-ARC PF00931.22 CDI76344.1 - 0.0056 15.9 0.1 0.0056 15.9 0.1 1.6 2 0 0 2 2 2 1 NB-ARC domain MeaB PF03308.16 CDI76344.1 - 0.0095 14.9 0.1 0.37 9.7 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CDI76344.1 - 0.026 14.6 4.4 0.22 11.6 4.3 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 CDI76344.1 - 0.031 14.2 0.1 0.099 12.5 0.1 1.8 1 1 0 1 1 1 0 NTPase cobW PF02492.19 CDI76344.1 - 0.035 13.7 0.1 0.16 11.5 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDI76344.1 - 0.037 14.3 0.1 0.12 12.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 CDI76344.1 - 0.043 13.7 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.18 CDI76344.1 - 0.058 13.1 0.4 0.058 13.1 0.4 2.7 2 1 0 3 3 3 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 CDI76344.1 - 0.059 12.6 0.2 0.059 12.6 0.2 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATP_bind_2 PF03668.15 CDI76344.1 - 0.11 11.7 0.2 0.24 10.6 0.2 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family AAA_33 PF13671.6 CDI76344.1 - 0.18 12.0 2.2 0.18 11.9 0.2 2.1 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 CDI76344.1 - 0.21 10.8 1.2 0.68 9.2 1.2 1.8 1 1 0 1 1 1 0 Septin ATPase_2 PF01637.18 CDI76344.1 - 0.29 11.0 0.0 0.29 11.0 0.0 1.9 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea TFIIA PF03153.13 CDI76344.1 - 0.46 10.4 35.6 0.18 11.8 27.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_14 PF13173.6 CDI76344.1 - 1.9 8.5 0.0 1.9 8.5 0.0 3.1 4 0 0 4 4 3 0 AAA domain Dynamin_N PF00350.23 CDI76344.1 - 5.2 7.1 15.9 0.2 11.7 8.2 2.4 2 1 0 2 2 2 0 Dynamin family AAA PF00004.29 CDI76344.1 - 8.2 6.9 6.7 1.7 9.1 1.3 2.6 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) UPF0242 PF06785.11 CDI76345.1 - 1.9e-05 24.8 10.8 1.9e-05 24.8 10.8 4.6 4 1 1 5 5 5 1 Uncharacterised protein family (UPF0242) N-terminus LMBR1 PF04791.16 CDI76345.1 - 0.0014 17.6 7.4 0.0014 17.6 7.4 2.6 2 1 0 2 2 2 1 LMBR1-like membrane protein DUF2722 PF10846.8 CDI76345.1 - 0.0056 15.7 8.9 0.0056 15.7 8.9 5.0 4 2 1 5 5 5 1 Protein of unknown function (DUF2722) KicB PF03882.14 CDI76345.1 - 0.08 13.2 2.0 0.091 13.0 0.0 2.1 2 0 0 2 2 2 0 MukF winged-helix domain ETRAMP PF09716.10 CDI76345.1 - 4 7.6 0.0 4 7.6 0.0 4.7 4 1 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) Kinesin PF00225.23 CDI76346.1 - 4.8e-53 180.2 0.8 4.8e-53 180.2 0.8 1.9 2 0 0 2 2 2 1 Kinesin motor domain ESM4 PF15952.5 CDI76346.1 - 0.022 15.2 8.7 0.038 14.4 8.7 1.4 1 0 0 1 1 1 0 Enhancer of split M4 family SMBP PF16785.5 CDI76346.1 - 0.083 13.1 1.1 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 Small metal-binding protein NADH_Oxid_Nqo15 PF11497.8 CDI76346.1 - 0.14 12.2 0.2 0.35 10.9 0.1 1.7 2 0 0 2 2 2 0 NADH-quinone oxidoreductase chain 15 DUF89 PF01937.19 CDI76346.1 - 0.18 10.7 2.9 0.28 10.1 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 PHC2_SAM_assoc PF16616.5 CDI76346.1 - 0.21 12.4 6.6 0.42 11.4 6.6 1.4 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Presenilin PF01080.17 CDI76346.1 - 2.2 7.0 10.9 2.9 6.6 10.9 1.1 1 0 0 1 1 1 0 Presenilin Syntaxin-18_N PF10496.9 CDI76346.1 - 2.3 8.5 0.0 2.3 8.5 0.0 2.8 2 1 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Methyltransf_31 PF13847.6 CDI76350.1 - 9.8e-06 25.4 0.0 1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI76350.1 - 0.002 18.7 0.0 0.003 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI76350.1 - 0.014 16.1 0.0 0.026 15.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDI76350.1 - 0.017 15.0 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PcrB PF01884.17 CDI76350.1 - 0.12 11.9 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 PcrB family SLX9 PF15341.6 CDI76351.1 - 1.5e-10 41.6 2.2 1.5e-10 41.6 2.2 2.2 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 RRN9 PF10680.9 CDI76351.1 - 0.066 13.5 0.3 0.066 13.5 0.3 2.4 4 0 0 4 4 4 0 RNA polymerase I specific transcription initiation factor Exonuc_VII_L PF02601.15 CDI76352.1 - 6.1 6.3 18.7 11 5.4 18.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Chorion_2 PF03964.15 CDI76353.1 - 0.008 17.0 3.2 0.008 17.0 3.2 21.8 10 7 9 21 21 21 2 Chorion family 2 AP2 PF00847.20 CDI76355.1 - 0.059 13.6 0.7 0.48 10.7 0.2 2.6 2 0 0 2 2 2 0 AP2 domain EOS1 PF12326.8 CDI76356.1 - 0.22 11.5 6.7 0.23 11.4 6.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF502 PF04367.13 CDI76356.1 - 0.62 10.0 2.1 1.4 8.8 2.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF502) Sec62 PF03839.16 CDI76356.1 - 2.1 7.8 14.7 2.3 7.7 14.7 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 FAM176 PF14851.6 CDI76356.1 - 6.3 6.4 8.5 8.1 6.1 8.5 1.2 1 0 0 1 1 1 0 FAM176 family AIF_C PF14721.6 CDI76356.1 - 7.1 7.0 11.4 9.3 6.6 11.4 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Rxt3 PF08642.10 CDI76356.1 - 10 6.9 9.4 13 6.6 9.4 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 SUIM_assoc PF16619.5 CDI76357.1 - 0.0032 17.5 2.1 0.0032 17.5 2.1 3.4 2 2 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI76357.1 - 0.044 14.1 7.0 0.64 10.3 7.0 2.0 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI76357.1 - 0.27 11.2 35.1 0.39 10.6 35.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TEX33 PF15400.6 CDI76357.1 - 1.8 9.1 9.3 0.16 12.5 0.4 2.4 1 1 1 2 2 2 0 Testis-expressed sequence 33 protein family OrfB_Zn_ribbon PF07282.11 CDI76357.1 - 2 8.4 6.7 3.3 7.7 0.1 2.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain RR_TM4-6 PF06459.12 CDI76358.1 - 0.54 10.0 23.2 0.59 9.9 23.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TT_ORF1 PF02956.14 CDI76358.1 - 0.67 8.6 19.8 0.86 8.2 19.8 1.0 1 0 0 1 1 1 0 TT viral orf 1 DUF3141 PF11339.8 CDI76358.1 - 1 7.7 17.9 1 7.7 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) CCSAP PF15748.5 CDI76358.1 - 1.1 9.4 26.8 1.2 9.3 26.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SID-1_RNA_chan PF13965.6 CDI76358.1 - 1.3 7.3 6.5 1.6 7.0 6.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RIFIN PF02009.16 CDI76358.1 - 1.9 8.3 19.1 2.2 8.1 19.1 1.0 1 0 0 1 1 1 0 Rifin Presenilin PF01080.17 CDI76358.1 - 2.9 6.6 28.2 2.9 6.5 28.2 1.2 1 0 0 1 1 1 0 Presenilin Caldesmon PF02029.15 CDI76358.1 - 2.9 6.6 25.8 3.3 6.4 25.8 1.1 1 0 0 1 1 1 0 Caldesmon DUF1387 PF07139.11 CDI76358.1 - 3.6 7.2 23.6 3.9 7.1 23.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FAM60A PF15396.6 CDI76358.1 - 3.8 7.5 18.8 4.5 7.2 18.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Velvet PF11754.8 CDI76358.1 - 3.8 7.4 22.3 4.9 7.0 22.3 1.3 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 CDI76358.1 - 4.3 6.7 25.9 4.9 6.5 25.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin eIF-3_zeta PF05091.12 CDI76358.1 - 4.4 6.2 26.8 5.5 5.8 26.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SLC12 PF03522.15 CDI76358.1 - 4.9 6.1 24.2 4.9 6.1 24.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 BORG_CEP PF14957.6 CDI76358.1 - 5.2 8.3 15.9 7 7.8 15.9 1.4 1 0 0 1 1 1 0 Cdc42 effector DUF4746 PF15928.5 CDI76358.1 - 5.9 6.2 14.4 6.5 6.1 14.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 CDI76358.1 - 7.6 6.5 20.8 8.3 6.4 20.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2347 PF09804.9 CDI76358.1 - 7.9 6.0 16.8 8.7 5.8 16.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) MRP-S27 PF10037.9 CDI76358.1 - 9 5.0 27.4 9.9 4.9 27.4 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 SUIM_assoc PF16619.5 CDI76359.1 - 0.0028 17.7 42.8 0.18 11.9 5.0 4.8 4 0 0 4 4 4 3 Unstructured region C-term to UIM in Ataxin3 RCR PF12273.8 CDI76359.1 - 0.44 11.2 8.5 1.9 9.2 0.2 3.6 3 0 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red GREB1 PF15782.5 CDI76359.1 - 8 3.4 12.2 12 2.8 12.2 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Tfb2 PF03849.14 CDI76361.1 - 3.1e-41 141.5 2.4 8.1e-26 90.8 0.0 3.3 3 0 0 3 3 3 3 Transcription factor Tfb2 Tfb2_C PF18307.1 CDI76361.1 - 0.0019 18.6 0.4 0.0048 17.3 0.4 1.7 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain PNISR PF15996.5 CDI76361.1 - 0.12 12.6 18.9 0.042 14.1 6.3 3.0 3 0 0 3 3 3 0 Arginine/serine-rich protein PNISR EOS1 PF12326.8 CDI76361.1 - 2.5 8.0 6.5 0.73 9.7 1.0 2.4 2 1 0 2 2 2 0 N-glycosylation protein FancD2 PF14631.6 CDI76361.1 - 7.3 3.8 12.3 4.9 4.4 0.3 2.1 2 0 0 2 2 2 0 Fanconi anaemia protein FancD2 nuclease Ras PF00071.22 CDI76362.1 - 9.7e-52 174.8 0.4 1.2e-51 174.6 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI76362.1 - 2.7e-32 111.5 0.2 6.3e-32 110.3 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI76362.1 - 5.3e-11 42.3 0.0 7.5e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDI76362.1 - 8.9e-07 28.6 0.1 1.9e-06 27.6 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDI76362.1 - 0.00045 20.3 0.0 0.0006 19.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI76362.1 - 0.0082 16.1 0.7 1.8 8.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 CDI76362.1 - 0.026 13.9 0.0 0.043 13.2 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region TfuA PF07812.12 CDI76365.1 - 0.85 9.4 5.0 0.26 11.0 0.4 2.5 2 0 0 2 2 2 0 TfuA-like protein Exonuc_VII_L PF02601.15 CDI76365.1 - 1.3 8.5 69.8 1.6 8.2 29.8 3.3 3 0 0 3 3 3 0 Exonuclease VII, large subunit Otopetrin PF03189.13 CDI76366.1 - 0.13 11.0 2.6 0.25 10.1 2.6 1.4 1 0 0 1 1 1 0 Otopetrin Peptidase_S64 PF08192.11 CDI76366.1 - 0.35 9.3 8.1 0.42 9.1 8.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 TFIIA PF03153.13 CDI76366.1 - 0.75 9.7 29.6 0.91 9.5 29.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI76366.1 - 2.5 6.8 14.6 3.2 6.4 14.6 1.3 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 CDI76366.1 - 2.5 7.6 19.3 3.5 7.1 19.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI76366.1 - 2.7 6.9 11.0 3.2 6.7 11.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Suf PF05843.14 CDI76366.1 - 4.5 7.2 14.7 7.6 6.4 14.7 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4175 PF13779.6 CDI76366.1 - 5.4 4.8 35.8 7.2 4.4 35.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAT1 PF09770.9 CDI76366.1 - 6.8 4.8 24.4 7.7 4.6 24.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.12 CDI76366.1 - 7.4 5.4 16.0 9.7 5.0 16.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GREB1 PF15782.5 CDI76366.1 - 8.3 3.4 13.8 9.2 3.2 13.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HCMV_UL124 PF17609.2 CDI76367.1 - 0.16 12.2 9.7 0.27 11.4 1.4 2.2 2 0 0 2 2 2 0 Family of unknown function RskA PF10099.9 CDI76367.1 - 0.33 11.2 12.1 0.039 14.3 1.9 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA GREB1 PF15782.5 CDI76367.1 - 5.3 4.0 24.2 3 4.8 22.9 1.2 1 1 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2681 PF10883.8 CDI76367.1 - 9.4 6.7 20.0 6.4 7.3 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) RskA PF10099.9 CDI76368.1 - 0.15 12.3 17.9 0.19 12.0 17.9 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Pam16 PF03656.13 CDI76368.1 - 0.17 11.9 3.8 0.22 11.6 3.8 1.3 1 0 0 1 1 1 0 Pam16 DUF3597 PF12200.8 CDI76368.1 - 1.2 9.6 6.6 1.8 9.1 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Coilin_N PF15862.5 CDI76369.1 - 0.0023 17.7 0.0 0.0023 17.7 0.0 3.1 2 1 1 3 3 3 1 Coilin N-terminus zf-HIT PF04438.16 CDI76373.1 - 0.00094 19.0 18.9 0.0014 18.4 18.9 1.3 1 0 0 1 1 1 1 HIT zinc finger Caldesmon PF02029.15 CDI76373.1 - 1.3 7.8 42.9 2.5 6.7 42.9 1.5 1 0 0 1 1 1 0 Caldesmon PrmA PF06325.13 CDI76374.1 - 1.5e-10 40.9 0.3 1.5e-10 40.9 0.3 2.2 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDI76374.1 - 2.8e-09 37.6 1.7 5.9e-09 36.5 0.1 2.5 3 0 0 3 3 2 1 Methyltransferase domain MTS PF05175.14 CDI76374.1 - 7.7e-09 35.3 0.1 5.6e-08 32.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDI76374.1 - 6.1e-08 33.2 0.2 1.3e-06 28.9 0.0 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI76374.1 - 9.8e-08 31.9 1.1 1.8e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI76374.1 - 2e-06 27.8 0.0 2e-06 27.8 0.0 2.9 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDI76374.1 - 0.00043 20.3 0.1 0.00085 19.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDI76374.1 - 0.00062 19.5 0.1 0.00062 19.5 0.1 2.1 3 0 0 3 3 1 1 Conserved hypothetical protein 95 PCMT PF01135.19 CDI76374.1 - 0.00087 19.1 0.1 0.0026 17.6 0.1 1.7 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 CDI76374.1 - 0.0035 18.1 4.0 0.019 15.7 0.0 3.6 2 2 2 4 4 4 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDI76374.1 - 0.0048 16.3 0.0 0.0076 15.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 CDI76374.1 - 0.0055 15.7 0.0 0.0055 15.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) TehB PF03848.14 CDI76374.1 - 0.0059 16.0 0.0 0.0098 15.3 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB CMAS PF02353.20 CDI76374.1 - 0.0091 15.3 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 CDI76374.1 - 0.021 14.6 0.5 0.05 13.4 0.0 1.8 2 0 0 2 2 2 0 Lysine methyltransferase Methyltransf_32 PF13679.6 CDI76374.1 - 0.021 14.8 0.0 0.021 14.8 0.0 3.1 2 1 0 2 2 1 0 Methyltransferase domain Met_10 PF02475.16 CDI76374.1 - 0.03 14.1 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein DUF4638 PF15472.6 CDI76374.1 - 0.82 9.4 5.0 1.6 8.4 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) BRF1 PF07741.13 CDI76374.1 - 2.2 8.7 12.3 0.28 11.6 5.6 2.7 2 0 0 2 2 2 0 Brf1-like TBP-binding domain PCIF1_WW PF12237.8 CDI76375.1 - 3.9e-22 78.7 3.0 6.7e-20 71.4 1.1 3.5 3 1 0 3 3 3 2 Phosphorylated CTD interacting factor 1 WW domain Spt20 PF12090.8 CDI76375.1 - 0.0082 15.8 0.7 0.0082 15.8 0.7 9.4 10 0 0 10 10 10 6 Spt20 family RskA PF10099.9 CDI76375.1 - 0.81 9.9 0.0 0.81 9.9 0.0 10.8 3 2 5 10 10 10 0 Anti-sigma-K factor rskA DNA_pol_A_exo1 PF01612.20 CDI76378.1 - 1.5e-06 28.1 0.0 2.6e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease Apt1 PF10351.9 CDI76378.1 - 0.16 10.8 5.8 0.32 9.8 5.8 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain Apc15p PF05841.11 CDI76378.1 - 5.9 7.7 9.2 0.11 13.4 1.0 2.3 2 1 0 2 2 2 0 Apc15p protein MAR_sialic_bdg PF10564.9 CDI76379.1 - 1.4e-52 175.6 19.0 8e-27 93.1 2.8 3.2 3 0 0 3 3 3 3 Sialic-acid binding micronemal adhesive repeat MAR_sialic_bdg PF10564.9 CDI76380.1 - 3.5e-23 81.5 2.7 4.5e-23 81.1 2.7 1.1 1 0 0 1 1 1 1 Sialic-acid binding micronemal adhesive repeat E1_dh PF00676.20 CDI76381.1 - 5.1e-82 275.2 0.0 7.2e-82 274.7 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CDI76381.1 - 5.3e-11 42.5 0.2 5.3e-11 42.5 0.2 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CDI76381.1 - 9.4e-05 21.7 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_N PF00456.21 CDI76381.1 - 0.00013 21.1 0.1 0.00054 19.0 0.0 1.8 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Ocnus PF05005.15 CDI76382.1 - 1e-21 77.1 0.1 1.7e-21 76.4 0.1 1.3 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) TPR_21 PF09976.9 CDI76382.1 - 0.017 14.9 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain ARD PF03079.14 CDI76383.1 - 0.15 12.3 1.6 0.29 11.3 1.6 1.5 1 0 0 1 1 1 0 ARD/ARD' family DUF4746 PF15928.5 CDI76383.1 - 6.9 6.0 19.5 2.3 7.6 14.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Wyosine_form PF08608.12 CDI76384.1 - 4.5e-20 71.8 0.0 9.9e-20 70.7 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 CDI76384.1 - 7e-17 62.3 0.0 1.2e-16 61.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily TFIIA PF03153.13 CDI76384.1 - 0.011 15.8 25.0 0.34 10.9 12.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CMD PF02627.20 CDI76384.1 - 0.017 15.1 3.5 0.04 14.0 0.1 3.0 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family DNA_ligase_aden PF01653.18 CDI76385.1 - 3.7e-47 161.0 0.1 1.3e-14 54.1 0.0 7.0 6 1 1 7 7 7 6 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 CDI76385.1 - 3.2e-24 84.6 0.1 6.2e-24 83.7 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain 5_3_exonuc PF01367.20 CDI76385.1 - 0.17 12.5 0.0 0.61 10.7 0.0 2.0 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold B56 PF01603.20 CDI76386.1 - 3.2e-160 533.7 6.2 3.2e-160 533.7 6.2 2.2 3 0 0 3 3 3 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 CDI76386.1 - 0.12 12.2 5.0 0.091 12.7 0.4 2.8 3 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal EPL1 PF10513.9 CDI76386.1 - 0.29 11.5 10.7 0.43 10.9 0.1 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF2722 PF10846.8 CDI76386.1 - 1.1 8.1 25.9 0.14 11.1 7.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF2052 PF09747.9 CDI76386.1 - 1.9 8.6 20.1 2.1 8.4 1.9 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) TFIIA PF03153.13 CDI76386.1 - 2.6 7.9 36.8 5.4 6.9 36.8 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ANAPC_CDC26 PF10471.9 CDI76386.1 - 3 8.8 41.1 1.8 9.5 14.7 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 CDI76386.1 - 3.7 7.1 36.1 1.2 8.7 13.8 2.3 2 0 0 2 2 2 0 Spt20 family SAPS PF04499.15 CDI76386.1 - 4.8 5.9 8.2 11 4.7 8.2 1.6 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DDE_3 PF13358.6 CDI76387.1 - 5.1 6.8 7.7 0.68 9.7 1.6 2.3 2 0 0 2 2 2 0 DDE superfamily endonuclease DNA_pol_E_B PF04042.16 CDI76393.1 - 9.6e-26 90.4 0.1 2.2e-25 89.3 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DUF4179 PF13786.6 CDI76393.1 - 0.039 14.4 0.1 0.039 14.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Dehydrin PF00257.19 CDI76393.1 - 1.3 9.6 10.8 0.21 12.1 3.1 2.3 2 0 0 2 2 2 0 Dehydrin DUF3138 PF11336.8 CDI76393.1 - 6.6 5.2 28.2 0.89 8.1 14.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Suf PF05843.14 CDI76393.1 - 7 6.5 14.7 9.9 6.0 14.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SLATT_1 PF18181.1 CDI76393.1 - 7.1 6.6 11.9 5.7 6.9 6.7 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Spt20 PF12090.8 CDI76393.1 - 9 5.8 28.3 12 5.4 28.3 1.2 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI76393.1 - 10 6.4 39.3 4.1 7.7 24.4 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI76394.1 - 0.45 10.5 26.6 1.6 8.7 2.2 2.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Inhibitor_I42 PF09394.10 CDI76398.1 - 0.0078 16.6 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 FAM176 PF14851.6 CDI76398.1 - 0.037 13.7 0.0 0.049 13.3 0.0 1.3 1 1 0 1 1 1 0 FAM176 family RIFIN PF02009.16 CDI76400.1 - 4.8 7.0 11.7 7.1 6.4 2.4 2.2 2 0 0 2 2 2 0 Rifin BAF1_ABF1 PF04684.13 CDI76400.1 - 8 5.4 22.8 2.3 7.2 0.1 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Mito_carr PF00153.27 CDI76401.1 - 5.8e-08 32.6 3.6 3.8e-05 23.5 0.7 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein ArsB PF02040.15 CDI76401.1 - 0.083 12.2 0.2 0.094 12.0 0.2 1.1 1 0 0 1 1 1 0 Arsenical pump membrane protein HemX PF04375.14 CDI76403.1 - 0.0077 15.6 7.7 0.0077 15.6 7.7 2.1 3 0 0 3 3 3 1 HemX, putative uroporphyrinogen-III C-methyltransferase EphA2_TM PF14575.6 CDI76403.1 - 0.067 14.1 0.3 0.62 11.0 0.4 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 CDI76403.1 - 0.17 11.5 3.3 0.89 9.2 0.0 2.4 2 0 0 2 2 2 0 FAM176 family EPL1 PF10513.9 CDI76403.1 - 5.1 7.5 10.4 4.8 7.6 3.7 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Pex14_N PF04695.13 CDI76403.1 - 7.9 7.1 28.1 0.42 11.3 7.3 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hydrolase_4 PF12146.8 CDI76404.1 - 4.1e-18 65.5 0.1 5.7e-14 52.0 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI76404.1 - 2.2e-13 50.5 0.2 9e-08 32.1 0.1 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDI76404.1 - 5.8e-10 40.2 1.2 1.6e-08 35.4 0.2 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 CDI76404.1 - 9.6e-08 31.1 0.0 0.0042 15.8 0.0 2.2 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 CDI76404.1 - 3.3e-05 23.5 0.0 6.6e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CDI76404.1 - 3.6e-05 23.4 0.0 0.00012 21.7 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 CDI76404.1 - 0.00052 19.8 0.0 0.21 11.3 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CDI76404.1 - 0.0021 18.0 0.0 0.0041 17.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 CDI76404.1 - 0.0046 17.1 0.0 0.0081 16.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.16 CDI76404.1 - 0.0081 16.0 0.0 0.1 12.4 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 CDI76404.1 - 0.0086 15.7 0.0 0.022 14.3 0.0 1.5 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 CDI76404.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Lipase_3 PF01764.25 CDI76404.1 - 0.037 13.9 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 CDI76404.1 - 0.12 12.1 0.0 0.51 10.0 0.0 1.8 1 1 1 2 2 2 0 PGAP1-like protein DUF818 PF05677.12 CDI76404.1 - 0.24 10.3 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) TAFII55_N PF04658.13 CDI76405.1 - 5.3e-10 39.3 2.6 6.4e-09 35.7 0.0 3.7 3 1 0 3 3 3 1 TAFII55 protein conserved region ELH PF02323.15 CDI76405.1 - 0.26 10.6 0.0 0.26 10.6 0.0 3.2 3 0 0 3 3 3 0 Egg-laying hormone precursor Ras PF00071.22 CDI76407.1 - 0.0022 17.6 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI76407.1 - 0.023 14.9 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Hydrolase_4 PF12146.8 CDI76408.1 - 1.7e-13 50.4 0.0 4.8e-08 32.6 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI76408.1 - 1.5e-10 41.2 0.0 1.7e-05 24.6 0.0 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 CDI76408.1 - 7.9e-07 28.0 0.0 0.0052 15.5 0.1 2.9 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 CDI76408.1 - 5.8e-06 27.1 0.0 2.7e-05 24.9 0.0 1.9 1 1 2 3 3 3 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDI76408.1 - 2.2e-05 24.0 0.0 5.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDI76408.1 - 9.3e-05 22.1 0.0 0.00027 20.6 0.0 1.7 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CDI76408.1 - 0.00034 20.2 0.0 0.0018 17.8 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 CDI76408.1 - 0.00061 19.7 0.0 0.0012 18.8 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 CDI76408.1 - 0.00066 19.4 0.0 0.0023 17.7 0.0 1.8 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 CDI76408.1 - 0.0022 17.8 0.0 0.0094 15.8 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DUF818 PF05677.12 CDI76408.1 - 0.021 13.8 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.11 CDI76408.1 - 0.021 14.7 0.0 0.14 12.0 0.0 2.0 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal LRR_6 PF13516.6 CDI76409.1 - 0.13 12.4 0.8 71 3.8 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich repeat Coilin_N PF15862.5 CDI76411.1 - 0.004 17.0 5.3 0.0065 16.3 1.2 3.0 1 1 1 2 2 2 1 Coilin N-terminus Beta-lactamase PF00144.24 CDI76411.1 - 0.0074 15.6 0.2 0.014 14.7 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase Macoilin PF09726.9 CDI76416.1 - 0.00045 18.9 23.5 0.026 13.1 26.7 1.9 2 0 0 2 2 2 1 Macoilin family TFIIA PF03153.13 CDI76416.1 - 0.0079 16.2 19.2 0.0079 16.2 19.2 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI76416.1 - 0.018 15.6 3.8 0.018 15.6 3.8 5.2 5 1 0 5 5 5 0 60s Acidic ribosomal protein DUF572 PF04502.13 CDI76416.1 - 3.8 7.0 15.8 7.2 6.1 15.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) SAGA-Tad1 PF12767.7 CDI76416.1 - 4 7.1 16.2 7.4 6.2 16.2 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit ubiquitin PF00240.23 CDI76418.1 - 2.1e-17 62.6 0.1 2.8e-17 62.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDI76418.1 - 1.9e-06 27.6 0.0 2.4e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDI76418.1 - 0.0015 18.9 0.1 0.0042 17.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 CDI76418.1 - 0.01 16.4 0.0 0.014 15.9 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain CLP_protease PF00574.23 CDI76418.1 - 0.048 13.5 0.2 0.054 13.4 0.2 1.1 1 0 0 1 1 1 0 Clp protease TB2_DP1_HVA22 PF03134.19 CDI76420.1 - 2.6e-11 43.3 2.5 2.3e-10 40.2 1.4 2.1 1 1 1 2 2 2 2 TB2/DP1, HVA22 family DEAD PF00270.29 CDI76421.1 - 7.4e-40 136.6 0.0 7.4e-40 136.6 0.0 2.3 3 0 0 3 3 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI76421.1 - 2.5e-30 105.1 1.7 8.9e-30 103.3 0.5 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain tRNA-synt_1b PF00579.25 CDI76421.1 - 0.0023 17.3 0.1 0.0067 15.8 0.1 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Presenilin PF01080.17 CDI76421.1 - 0.0071 15.2 2.4 0.0086 14.9 2.4 1.2 1 0 0 1 1 1 1 Presenilin DUF2722 PF10846.8 CDI76421.1 - 0.023 13.6 17.7 0.033 13.1 17.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI76421.1 - 0.034 14.3 1.2 0.053 13.7 1.2 1.4 1 0 0 1 1 1 0 DDHD domain TPX2_importin PF12214.8 CDI76421.1 - 0.035 14.3 4.2 0.074 13.2 4.2 1.5 1 0 0 1 1 1 0 Cell cycle regulated microtubule associated protein SpoIIP PF07454.11 CDI76421.1 - 0.045 13.2 5.3 0.063 12.7 5.3 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CMS1 PF14617.6 CDI76421.1 - 0.2 10.9 0.0 0.2 10.9 0.0 3.0 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit TMEM51 PF15345.6 CDI76421.1 - 0.64 9.8 7.1 1 9.1 7.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Band_3_cyto PF07565.13 CDI76421.1 - 0.87 9.3 5.3 0.61 9.8 3.6 1.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Suf PF05843.14 CDI76421.1 - 5.6 6.9 14.5 11 5.9 14.5 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) AIF_C PF14721.6 CDI76421.1 - 6.2 7.2 11.1 12 6.3 11.1 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TERB2 PF15101.6 CDI76421.1 - 6.4 6.8 15.4 12 5.9 15.4 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RskA PF10099.9 CDI76422.1 - 0.0032 17.8 12.6 0.0032 17.8 12.6 40.2 12 9 19 31 31 31 5 Anti-sigma-K factor rskA DEAD PF00270.29 CDI76424.1 - 1.5e-11 44.4 1.2 5.8e-07 29.4 0.6 3.5 2 1 0 2 2 2 2 DEAD/DEAH box helicase SPX PF03105.19 CDI76424.1 - 4.8e-05 23.5 2.7 4.8e-05 23.5 2.7 2.2 2 0 0 2 2 2 2 SPX domain Velvet PF11754.8 CDI76424.1 - 0.031 14.2 9.1 0.012 15.6 3.0 2.2 2 0 0 2 2 2 0 Velvet factor Apt1 PF10351.9 CDI76424.1 - 0.067 12.0 24.2 0.01 14.7 12.1 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF908 PF06012.12 CDI76424.1 - 0.15 11.5 17.5 0.097 12.1 6.8 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Ecl1 PF12855.7 CDI76424.1 - 0.76 10.9 39.1 0.94 10.6 22.5 2.3 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins DUF1428 PF07237.11 CDI76425.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) SLC12 PF03522.15 CDI76427.1 - 0.013 14.5 31.7 0.014 14.5 31.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 AAA_11 PF13086.6 CDI76427.1 - 1.5 8.6 31.9 1.7 8.3 31.9 1.1 1 0 0 1 1 1 0 AAA domain Zip PF02535.22 CDI76427.1 - 2.4 7.3 23.6 2.8 7.1 23.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI76427.1 - 4.9 5.1 30.8 7.6 4.5 30.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Presenilin PF01080.17 CDI76427.1 - 8.3 5.1 45.8 9.8 4.8 45.8 1.0 1 0 0 1 1 1 0 Presenilin DUF3708 PF12501.8 CDI76427.1 - 9.8 5.9 7.3 14 5.4 7.3 1.3 1 1 0 1 1 1 0 Phosphate ATP-binding cassette transporter Radial_spoke PF04712.12 CDI76428.1 - 5.4e-74 249.9 22.5 1.4e-52 179.3 0.0 4.0 2 1 2 4 4 4 3 Radial spokehead-like protein Methyltr_RsmB-F PF01189.17 CDI76430.1 - 2.2e-16 60.1 11.6 2.2e-09 37.2 0.0 4.2 3 1 1 4 4 4 3 16S rRNA methyltransferase RsmB/F Methyltrans_SAM PF10672.9 CDI76430.1 - 0.016 14.4 0.1 0.32 10.1 0.1 2.4 2 0 0 2 2 2 0 S-adenosylmethionine-dependent methyltransferase Methyltransf_12 PF08242.12 CDI76430.1 - 0.019 15.7 1.9 1.3 9.9 0.7 2.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDI76430.1 - 0.13 13.0 4.0 5 7.8 0.0 3.2 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_25 PF13649.6 CDI76430.1 - 0.36 11.6 0.1 0.36 11.6 0.1 4.0 3 2 1 4 4 4 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDI76430.1 - 0.48 10.3 11.5 2.9 7.7 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain DUF3381 PF11861.8 CDI76430.1 - 0.81 9.5 20.2 0.092 12.5 12.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) AAA_23 PF13476.6 CDI76430.1 - 1.7 9.1 20.2 2 8.9 17.7 2.1 2 0 0 2 2 2 0 AAA domain FtsJ PF01728.19 CDI76430.1 - 1.9 8.6 12.7 2.3 8.3 3.1 3.0 2 1 0 2 2 2 0 FtsJ-like methyltransferase SpoIIIAH PF12685.7 CDI76430.1 - 4 7.2 44.3 2.7 7.8 5.5 2.8 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF2722 PF10846.8 CDI76431.1 - 0.011 14.7 0.1 0.011 14.7 0.1 3.1 2 1 1 3 3 2 0 Protein of unknown function (DUF2722) CclA_1 PF16942.5 CDI76431.1 - 0.16 12.3 3.9 0.46 10.8 3.9 1.8 1 0 0 1 1 1 0 Putative cyclic bacteriocin MMR1 PF08505.10 CDI76431.1 - 0.82 9.9 18.7 2.5 8.3 12.5 2.6 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Coilin_N PF15862.5 CDI76431.1 - 1.2 8.9 14.2 0.097 12.5 0.7 2.9 3 0 0 3 3 3 0 Coilin N-terminus DUF719 PF05334.13 CDI76431.1 - 2.1 8.5 9.0 8.6 6.5 4.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF719) MPM1 PF17234.2 CDI76431.1 - 2.2 8.5 9.5 18 5.5 6.4 2.5 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 CPSF100_C PF13299.6 CDI76431.1 - 2.8 8.1 10.1 5.5 7.2 4.9 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Med15 PF09606.10 CDI76431.1 - 5.1 5.7 44.4 0.39 9.4 26.3 2.5 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI76431.1 - 7.4 6.1 35.3 4.4 6.9 2.1 4.1 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein Shadoo PF14999.6 CDI76431.1 - 7.4 6.7 23.0 2.4 8.3 8.4 3.5 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective Peptidase_S49_N PF08496.10 CDI76431.1 - 8.6 6.4 9.4 22 5.1 6.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal UQ_con PF00179.26 CDI76434.1 - 3.6e-37 127.1 0.0 4.1e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI76434.1 - 0.002 17.8 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDI76434.1 - 0.0039 17.5 0.0 0.0058 16.9 0.0 1.3 1 0 0 1 1 1 1 RWD domain ASH PF15780.5 CDI76436.1 - 5.1e-06 26.6 2.1 0.061 13.5 0.0 4.5 4 1 1 5 5 5 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin RskA PF10099.9 CDI76436.1 - 4e-05 24.0 2.2 4e-05 24.0 2.2 2.6 2 1 1 3 3 3 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI76436.1 - 0.29 11.2 11.5 0.22 11.6 5.4 3.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SARAF PF06682.12 CDI76436.1 - 2 8.0 11.9 0.84 9.2 9.3 1.7 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Dus PF01207.17 CDI76437.1 - 4.9e-47 160.5 0.0 1.6e-28 99.7 0.0 2.1 1 1 0 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 CDI76437.1 - 4.7e-05 22.8 0.0 0.0016 17.7 0.0 2.1 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 CDI76437.1 - 0.0002 20.9 0.0 0.00038 20.0 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 CDI76437.1 - 0.0034 16.8 0.7 0.0051 16.2 0.7 1.3 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CDI76437.1 - 0.0034 16.4 0.1 0.0067 15.5 0.1 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain G3P_antiterm PF04309.12 CDI76437.1 - 0.004 16.6 0.0 0.0071 15.8 0.0 1.4 1 0 0 1 1 1 1 Glycerol-3-phosphate responsive antiterminator DUF3446 PF11928.8 CDI76437.1 - 0.29 11.5 10.6 1.9 8.8 8.2 2.7 2 1 0 2 2 2 0 Early growth response N-terminal domain Herpes_pp85 PF04637.12 CDI76437.1 - 2 6.7 4.4 2.8 6.3 4.4 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SR-25 PF10500.9 CDI76437.1 - 2.3 7.8 9.9 3.7 7.1 9.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 CDI76439.1 - 5.7e-27 94.7 0.2 3.1e-16 59.5 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76439.1 - 9.9e-16 57.8 0.0 3e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase RskA PF10099.9 CDI76439.1 - 0.0056 17.0 12.1 0.0056 17.0 12.1 9.5 4 3 2 6 6 6 1 Anti-sigma-K factor rskA Ribosomal_S2 PF00318.20 CDI76439.1 - 0.25 10.5 1.5 0.46 9.7 1.5 1.4 1 0 0 1 1 1 0 Ribosomal protein S2 APH PF01636.23 CDI76439.1 - 1.8 8.4 0.0 1.8 8.4 0.0 4.3 5 1 0 5 5 5 0 Phosphotransferase enzyme family SUIM_assoc PF16619.5 CDI76440.1 - 0.0083 16.2 8.2 0.0083 16.2 8.2 4.5 5 1 0 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 DUF1635 PF07795.11 CDI76440.1 - 0.88 9.4 19.0 0.051 13.4 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1635) Utp11 PF03998.13 CDI76441.1 - 4e-21 76.1 43.9 7.3e-21 75.2 43.9 1.5 1 1 0 1 1 1 1 Utp11 protein tRNA_int_endo PF01974.17 CDI76442.1 - 1.5e-10 41.0 0.0 6.3e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 tRNA intron endonuclease, catalytic C-terminal domain DUF4452 PF14618.6 CDI76442.1 - 0.0086 16.0 1.2 0.01 15.7 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) DUF3678 PF12435.8 CDI76442.1 - 0.13 11.7 0.0 0.13 11.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) adh_short PF00106.25 CDI76443.1 - 2.2e-18 66.4 0.5 4.3e-10 39.4 0.1 2.1 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 CDI76443.1 - 2e-07 31.1 0.2 1.9e-06 27.9 0.0 2.1 1 1 1 2 2 2 1 KR domain adh_short_C2 PF13561.6 CDI76443.1 - 2.1e-06 27.5 0.3 0.029 13.9 0.1 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CDI76443.1 - 0.00025 20.3 0.0 0.00033 19.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CDI76443.1 - 0.0043 17.0 0.0 0.0064 16.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 CDI76443.1 - 0.017 15.7 0.2 0.038 14.6 0.2 1.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 CDI76443.1 - 0.095 12.1 0.0 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CDI76443.1 - 0.11 12.5 0.1 0.17 12.0 0.1 1.4 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.23 CDI76443.1 - 0.16 12.0 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain zf-B_box PF00643.24 CDI76444.1 - 1.4e-09 38.0 9.4 6.7e-05 23.0 1.5 2.2 2 0 0 2 2 2 2 B-box zinc finger CEBP_ZZ PF16366.5 CDI76444.1 - 0.00085 19.5 3.9 0.00085 19.5 3.9 1.8 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain DUF3138 PF11336.8 CDI76444.1 - 9.8 4.7 7.4 13 4.2 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Peptidase_M14 PF00246.24 CDI76446.1 - 5.2e-28 98.7 0.0 5.2e-28 98.7 0.0 4.1 3 1 1 4 4 4 2 Zinc carboxypeptidase Pex14_N PF04695.13 CDI76446.1 - 1.8e-05 25.4 10.2 1.8e-05 25.4 10.2 8.3 6 3 0 6 6 6 3 Peroxisomal membrane anchor protein (Pex14p) conserved region RPOL_N PF14700.6 CDI76446.1 - 0.0025 17.3 1.1 0.0025 17.3 1.1 6.3 6 0 0 6 6 6 4 DNA-directed RNA polymerase N-terminal BAF1_ABF1 PF04684.13 CDI76446.1 - 3.6 6.6 89.2 0.59 9.1 22.6 5.1 5 0 0 5 5 5 0 BAF1 / ABF1 chromatin reorganising factor Pex19 PF04614.12 CDI76448.1 - 2.1 8.1 4.3 1.4 8.6 0.1 2.4 2 1 1 3 3 3 0 Pex19 protein family Mic1 PF07035.12 CDI76450.1 - 1.8e-05 24.5 5.2 0.0011 18.7 0.0 3.0 3 0 0 3 3 3 2 Colon cancer-associated protein Mic1-like DASH_Dam1 PF08653.10 CDI76451.1 - 0.093 12.5 0.2 17 5.3 0.0 2.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 Med3 PF11593.8 CDI76451.1 - 0.24 10.6 11.6 0.28 10.3 11.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FSA_C PF10479.9 CDI76451.1 - 3.5 5.6 4.8 4.1 5.4 4.8 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CCDC53 PF10152.9 CDI76451.1 - 3.7 8.0 5.2 5.6 7.4 4.7 1.5 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex MSP1_C PF07462.11 CDI76451.1 - 6.2 5.4 5.6 8.5 4.9 5.6 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus RAB3GAP2_N PF14655.6 CDI76452.1 - 1.5e-06 27.8 13.2 2.1e-05 24.0 1.8 3.1 3 0 0 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIIA PF03153.13 CDI76452.1 - 0.0028 17.7 8.5 0.0028 17.7 8.5 3.6 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 CDI76453.1 - 4.4 7.7 17.2 4.7 7.6 17.2 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex G6B PF15096.6 CDI76453.1 - 5.1 6.8 6.2 5.6 6.7 6.2 1.1 1 0 0 1 1 1 0 G6B family FAM60A PF15396.6 CDI76453.1 - 9.7 6.1 11.1 10 6.1 11.1 1.0 1 0 0 1 1 1 0 Protein Family FAM60A SR-25 PF10500.9 CDI76454.1 - 0.0012 18.5 0.8 0.0012 18.5 0.8 9.1 4 2 3 7 7 7 1 Nuclear RNA-splicing-associated protein MPM1 PF17234.2 CDI76454.1 - 0.0013 19.0 4.8 0.0013 19.0 4.8 10.5 5 2 0 5 5 5 2 Mitochondrial peculiar membrane protein 1 LON_substr_bdg PF02190.16 CDI76455.1 - 1.9e-16 60.6 0.0 9.5e-15 55.0 0.0 2.7 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain TFIIA PF03153.13 CDI76455.1 - 1.4e-05 25.3 58.8 0.0001 22.4 33.5 2.5 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 CDI76455.1 - 1.5 8.3 28.8 4.5 6.8 0.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) MMR1 PF08505.10 CDI76455.1 - 1.8 8.8 39.4 1.3 9.2 28.7 2.4 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI76455.1 - 2.9 7.4 41.7 0.91 9.0 27.8 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI76455.1 - 4.7 5.3 45.2 0.051 11.9 25.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SAGA-Tad1 PF12767.7 CDI76455.1 - 5.4 6.7 21.2 10 5.8 17.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit NPR3 PF03666.13 CDI76455.1 - 6.1 5.5 24.0 0.094 11.5 16.5 1.8 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 NAC PF01849.18 CDI76456.1 - 1.8e-20 72.6 0.5 2.9e-20 72.0 0.5 1.3 1 0 0 1 1 1 1 NAC domain SEEEED PF14797.6 CDI76456.1 - 0.018 15.2 9.9 0.034 14.3 9.9 1.4 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex RskA PF10099.9 CDI76456.1 - 0.79 10.0 10.6 0.28 11.4 6.8 1.8 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TraG-D_C PF12696.7 CDI76456.1 - 5.5 7.0 6.5 8 6.5 0.1 2.3 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG PGK PF00162.19 CDI76457.1 - 2.3e-146 487.6 2.5 2.6e-146 487.4 2.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase zf-CCCH PF00642.24 CDI76459.1 - 0.00041 20.2 7.5 0.043 13.7 1.5 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PA26 PF04636.13 CDI76459.1 - 0.00085 18.4 5.8 0.00085 18.4 5.8 3.9 3 1 1 4 4 4 1 PA26 p53-induced protein (sestrin) zf_CCCH_4 PF18345.1 CDI76459.1 - 2.1 8.5 6.9 0.73 10.0 1.0 2.5 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_2 PF14608.6 CDI76459.1 - 2.9 8.5 5.9 10 6.7 0.3 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger SUIM_assoc PF16619.5 CDI76464.1 - 0.0087 16.1 6.1 0.013 15.6 6.1 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF2967 PF11179.8 CDI76464.1 - 0.036 12.2 5.0 0.044 11.9 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF2722 PF10846.8 CDI76464.1 - 0.049 12.6 3.2 0.058 12.3 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI76464.1 - 0.12 12.0 9.2 0.16 11.5 9.2 1.2 1 0 0 1 1 1 0 Spt20 family TSA PF03249.13 CDI76464.1 - 0.19 10.4 5.4 0.25 10.1 5.4 1.1 1 0 0 1 1 1 0 Type specific antigen NAD_binding_4 PF07993.12 CDI76465.1 - 1.1e-52 178.7 0.0 8e-52 176.0 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CDI76465.1 - 2.1e-08 33.9 0.0 4.9e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDI76465.1 - 6.3e-07 28.7 0.1 6.2e-06 25.4 0.1 2.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2722 PF10846.8 CDI76465.1 - 0.00073 18.6 2.2 0.00074 18.6 0.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI76465.1 - 0.0011 18.7 5.4 0.0016 18.1 5.4 1.2 1 0 0 1 1 1 1 Spt20 family GDP_Man_Dehyd PF16363.5 CDI76465.1 - 0.011 15.2 5.6 0.017 14.5 1.3 2.5 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDI76465.1 - 0.011 14.9 1.2 1.9 7.6 0.1 2.9 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein Ciart PF15673.5 CDI76465.1 - 0.086 12.2 1.0 6.8 6.0 0.0 2.3 2 0 0 2 2 2 0 Circadian-associated transcriptional repressor SepSecS PF05889.13 CDI76467.1 - 7.1e-66 222.5 0.0 4.2e-61 206.8 0.0 2.7 1 1 1 2 2 2 2 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 CDI76467.1 - 0.097 11.9 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Sporozoite_P67 PF05642.11 CDI76468.1 - 0.0061 14.7 4.5 0.057 11.5 0.1 2.1 2 0 0 2 2 2 2 Sporozoite P67 surface antigen GREB1 PF15782.5 CDI76468.1 - 0.099 9.8 8.5 0.13 9.3 8.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pex14_N PF04695.13 CDI76468.1 - 0.11 13.2 22.0 3.5 8.3 19.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4179 PF13786.6 CDI76468.1 - 0.2 12.1 0.3 0.2 12.1 0.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) TFIIA PF03153.13 CDI76468.1 - 0.29 11.1 30.3 0.17 11.8 27.4 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2368 PF10166.9 CDI76468.1 - 0.38 10.4 11.6 1.1 8.8 11.6 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Velvet PF11754.8 CDI76468.1 - 2.9 7.8 13.3 30 4.4 12.2 2.1 2 0 0 2 2 2 0 Velvet factor TPPII_N PF12583.8 CDI76468.1 - 6.3 7.4 23.1 4.9 7.7 5.5 2.4 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal Suf PF05843.14 CDI76468.1 - 6.5 6.6 16.9 11 5.9 16.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 CDI76469.1 - 1 8.0 12.5 1.9 7.0 12.5 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ribosomal_60s PF00428.19 CDI76469.1 - 2.9 8.5 8.8 41 4.9 0.0 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Filamin PF00630.19 CDI76470.1 - 4.7e-18 65.9 0.0 2.3e-17 63.7 0.0 2.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat CSD PF00313.22 CDI76471.1 - 0.00058 19.7 0.1 0.003 17.4 0.0 2.0 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDI76471.1 - 0.19 11.4 0.3 0.51 10.1 0.2 1.8 1 1 1 2 2 2 0 Ribonuclease B OB domain RskA PF10099.9 CDI76472.1 - 3.7e-05 24.1 44.8 0.024 14.9 0.4 3.9 2 2 1 3 3 3 3 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI76472.1 - 0.0031 17.1 9.7 0.0031 17.1 9.7 4.0 3 1 0 3 3 3 2 Spt20 family DUF2722 PF10846.8 CDI76472.1 - 0.0056 15.7 8.4 0.0056 15.7 8.4 4.1 3 1 0 3 3 3 1 Protein of unknown function (DUF2722) MMS1_N PF10433.9 CDI76473.1 - 1.2e-137 459.5 0.0 2.7e-137 458.4 0.0 1.5 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CDI76473.1 - 3e-07 30.1 0.0 1.2e-06 28.1 0.0 2.1 2 1 1 3 3 3 1 CPSF A subunit region Bac_luciferase PF00296.20 CDI76475.1 - 0.017 14.5 6.4 0.081 12.3 0.2 2.2 2 0 0 2 2 2 0 Luciferase-like monooxygenase Adaptin_binding PF10199.9 CDI76475.1 - 0.036 14.7 0.9 0.056 14.0 0.9 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Ribosomal_60s PF00428.19 CDI76475.1 - 0.71 10.5 29.3 0.42 11.2 14.2 2.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein Shadoo PF14999.6 CDI76475.1 - 2.2 8.4 26.5 0.92 9.6 11.0 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Cyclin_N PF00134.23 CDI76477.1 - 0.0022 17.7 1.9 0.0022 17.7 1.9 5.0 5 0 0 5 5 5 1 Cyclin, N-terminal domain RskA PF10099.9 CDI76477.1 - 0.0029 17.9 3.5 0.0029 17.9 3.5 6.6 2 2 2 4 4 4 1 Anti-sigma-K factor rskA HTH_20 PF12840.7 CDI76477.1 - 0.02 14.9 0.2 0.11 12.5 0.2 2.3 1 0 0 1 1 1 0 Helix-turn-helix domain Phytase PF02333.15 CDI76477.1 - 0.13 11.2 1.0 0.27 10.1 1.0 1.5 1 0 0 1 1 1 0 Phytase Tudor-knot PF11717.8 CDI76478.1 - 0.16 11.9 2.1 0.53 10.2 2.1 1.9 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Hamartin PF04388.12 CDI76478.1 - 1.7 7.2 47.6 2.1 6.9 47.6 1.0 1 0 0 1 1 1 0 Hamartin protein ASD2 PF08687.11 CDI76479.1 - 0.87 9.1 5.7 0.94 9.0 5.7 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 CobT PF06213.12 CDI76479.1 - 0.87 8.9 5.2 0.9 8.9 5.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SPX PF03105.19 CDI76479.1 - 1.9 8.3 23.7 2.3 8.1 23.7 1.1 1 0 0 1 1 1 0 SPX domain Striatin PF08232.12 CDI76479.1 - 2.1 8.9 6.5 2.6 8.6 6.5 1.1 1 0 0 1 1 1 0 Striatin family GEMIN8 PF15348.6 CDI76479.1 - 2.8 8.2 10.3 2.9 8.1 10.3 1.0 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Presenilin PF01080.17 CDI76479.1 - 3.3 6.4 11.0 3.3 6.4 11.0 1.0 1 0 0 1 1 1 0 Presenilin ATG16 PF08614.11 CDI76479.1 - 4.3 7.5 6.7 5.7 7.1 6.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) AAR2 PF05282.11 CDI76481.1 - 0.0033 16.9 0.1 0.0033 16.9 0.1 4.4 1 1 3 4 4 4 2 AAR2 protein Macoilin PF09726.9 CDI76481.1 - 0.052 12.1 56.5 0.013 14.1 33.3 2.3 2 0 0 2 2 2 0 Macoilin family DUF2052 PF09747.9 CDI76481.1 - 6.7 6.8 43.8 0.3 11.2 10.2 3.1 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) RRM_1 PF00076.22 CDI76482.1 - 2e-17 62.8 0.1 3.6e-17 61.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 CDI76482.1 - 0.0031 17.6 5.0 0.0033 17.5 5.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SRP_SPB PF02978.19 CDI76482.1 - 0.0032 18.0 0.6 0.0096 16.5 0.6 1.7 1 0 0 1 1 1 1 Signal peptide binding domain Exosortase_EpsH PF09721.10 CDI76482.1 - 0.38 10.2 4.2 0.49 9.9 4.2 1.1 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) SpoU_methylase PF00588.19 CDI76484.1 - 5.3e-09 36.4 0.0 9.8e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family CH_2 PF06294.11 CDI76486.1 - 2.6e-15 56.3 0.1 1.3e-07 31.7 0.0 2.8 2 0 0 2 2 2 2 CH-like domain in sperm protein RskA PF10099.9 CDI76487.1 - 0.00013 22.3 0.9 0.00013 22.3 0.9 2.5 2 1 0 2 2 2 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI76487.1 - 0.00019 21.6 67.9 0.039 13.9 30.4 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Sulfotransfer_1 PF00685.27 CDI76487.1 - 0.00036 20.1 4.3 0.00036 20.1 4.3 1.9 2 0 0 2 2 2 1 Sulfotransferase domain DUF1682 PF07946.14 CDI76487.1 - 0.0053 16.0 2.0 0.0053 16.0 2.0 2.1 2 0 0 2 2 1 1 Protein of unknown function (DUF1682) DUF2076 PF09849.9 CDI76487.1 - 0.0058 16.7 14.8 0.0058 16.7 14.8 3.7 3 2 0 3 3 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CNDH2_C PF16858.5 CDI76487.1 - 0.06 13.2 28.9 0.36 10.7 11.9 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term BAF1_ABF1 PF04684.13 CDI76487.1 - 0.067 12.2 32.9 0.0094 15.1 21.7 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Med15 PF09606.10 CDI76487.1 - 2.2 6.9 53.9 1.8 7.1 27.7 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Radical_SAM_N PF08497.10 CDI76487.1 - 2.4 7.3 15.1 4.2 6.5 1.5 2.1 2 0 0 2 2 2 0 Radical SAM N-terminal Pinin_SDK_memA PF04696.13 CDI76487.1 - 2.5 8.2 47.5 1.2 9.1 20.2 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Connexin PF00029.19 CDI76487.1 - 4.1 7.1 24.5 0.14 11.9 6.4 3.1 3 0 0 3 3 3 0 Connexin Tfb2 PF03849.14 CDI76487.1 - 5.1 6.0 28.5 3.8 6.4 12.3 2.1 2 0 0 2 2 2 0 Transcription factor Tfb2 PepSY_TM PF03929.16 CDI76487.1 - 7 6.2 14.1 7.2 6.2 6.4 2.2 2 0 0 2 2 2 0 PepSY-associated TM region Utp14 PF04615.13 CDI76487.1 - 9.4 4.7 43.3 20 3.6 43.3 1.5 1 1 0 1 1 1 0 Utp14 protein O-antigen_lig PF13425.6 CDI76488.1 - 0.071 11.9 3.8 7.5 5.2 1.2 3.3 3 0 0 3 3 3 0 O-antigen ligase like membrane protein DnaJ PF00226.31 CDI76489.1 - 3.5e-11 43.1 0.0 4.1e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 DnaJ domain RskA PF10099.9 CDI76490.1 - 0.00011 22.5 16.9 0.069 13.4 0.1 2.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA AAA_24 PF13479.6 CDI76490.1 - 0.0029 17.4 0.0 0.0061 16.3 0.0 1.5 2 0 0 2 2 2 1 AAA domain Spt20 PF12090.8 CDI76490.1 - 0.004 16.8 5.3 0.004 16.8 5.3 1.7 2 0 0 2 2 2 1 Spt20 family DUF2828 PF11443.8 CDI76490.1 - 0.013 13.6 0.1 0.013 13.6 0.1 1.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) AAA_2 PF07724.14 CDI76490.1 - 0.037 14.2 0.1 0.076 13.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF5421 PF17458.2 CDI76490.1 - 0.82 9.0 8.1 1.6 8.0 8.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5421) DUF2722 PF10846.8 CDI76490.1 - 0.82 8.6 10.7 0.15 10.9 7.3 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) GN3L_Grn1 PF08701.11 CDI76490.1 - 3.1 8.0 18.2 0.84 9.8 3.1 3.2 2 1 1 3 3 3 0 GNL3L/Grn1 putative GTPase TFIIA PF03153.13 CDI76492.1 - 5.6 6.8 83.6 0.12 12.4 5.2 4.9 5 1 0 5 5 5 0 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.11 CDI76493.1 - 0.0013 16.9 12.6 0.0013 16.9 12.6 4.7 5 1 0 5 5 5 1 Sporozoite P67 surface antigen Spt20 PF12090.8 CDI76493.1 - 0.0026 17.4 29.0 0.0026 17.4 29.0 9.7 6 2 0 6 6 6 4 Spt20 family Utp14 PF04615.13 CDI76493.1 - 0.63 8.5 52.2 0.004 15.8 14.8 3.2 3 0 0 3 3 3 0 Utp14 protein SID-1_RNA_chan PF13965.6 CDI76493.1 - 5.5 5.3 20.4 2.5 6.4 9.1 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 SDA1 PF05285.12 CDI76493.1 - 6.2 6.2 37.8 0.047 13.1 6.1 3.4 3 0 0 3 3 3 0 SDA1 Cpn60_TCP1 PF00118.24 CDI76495.1 - 8.3e-43 146.7 0.4 9.3e-43 146.6 0.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PPTA PF01239.22 CDI76496.1 - 3.6e-16 58.3 11.8 2.8e-09 36.4 4.2 3.5 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat Pex14_N PF04695.13 CDI76496.1 - 0.0015 19.2 5.0 0.0063 17.2 1.9 2.2 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Pinin_SDK_memA PF04696.13 CDI76496.1 - 0.0026 17.8 11.4 0.0057 16.7 11.4 1.5 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region DUF2052 PF09747.9 CDI76496.1 - 0.0036 17.5 5.5 0.0036 17.5 5.5 1.5 2 0 0 2 2 1 1 Coiled-coil domain containing protein (DUF2052) CAF1 PF04857.20 CDI76496.1 - 0.0064 15.7 0.6 0.0068 15.6 0.6 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease Spt20 PF12090.8 CDI76496.1 - 0.01 15.5 14.0 0.02 14.5 14.0 1.5 1 0 0 1 1 1 0 Spt20 family AAA_23 PF13476.6 CDI76496.1 - 0.01 16.4 2.6 0.011 16.2 2.6 1.2 1 0 0 1 1 1 0 AAA domain DUF3464 PF11947.8 CDI76496.1 - 0.017 14.9 1.4 0.03 14.1 1.4 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 AKAP95 PF04988.12 CDI76496.1 - 0.022 15.0 2.1 0.032 14.4 2.1 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) FAM176 PF14851.6 CDI76496.1 - 0.024 14.3 1.3 0.024 14.3 1.3 1.6 2 0 0 2 2 1 0 FAM176 family PEX11 PF05648.14 CDI76496.1 - 0.033 13.7 2.2 0.058 12.9 2.2 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) FHIPEP PF00771.20 CDI76496.1 - 0.041 12.4 1.3 0.046 12.2 1.3 1.1 1 0 0 1 1 1 0 FHIPEP family EIIBC-GUT_N PF03612.14 CDI76496.1 - 0.042 13.6 2.7 0.068 12.9 2.7 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Lipase_GDSL PF00657.22 CDI76496.1 - 0.063 13.2 0.1 0.075 13.0 0.1 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase MDMPI_N PF11716.8 CDI76496.1 - 0.11 13.2 7.6 0.21 12.3 7.6 1.4 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain RBP_receptor PF14752.6 CDI76496.1 - 0.13 10.8 3.2 0.19 10.3 3.2 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor Spore_III_AF PF09581.10 CDI76496.1 - 0.16 12.0 6.9 0.29 11.1 6.9 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Ureide_permease PF07168.11 CDI76496.1 - 0.16 10.7 1.7 0.23 10.1 1.7 1.2 1 0 0 1 1 1 0 Ureide permease PBP_sp32 PF07222.12 CDI76496.1 - 0.17 11.3 11.4 0.32 10.4 11.4 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF3499 PF12005.8 CDI76496.1 - 0.19 12.3 4.2 0.38 11.3 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) OATP PF03137.20 CDI76496.1 - 0.21 9.8 1.1 0.33 9.2 1.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family OSTbeta PF15048.6 CDI76496.1 - 0.36 11.0 4.6 0.48 10.6 2.5 2.1 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein CPSF100_C PF13299.6 CDI76496.1 - 0.67 10.1 7.8 0.14 12.3 3.6 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal tRNA_synt_1c_R2 PF04557.15 CDI76496.1 - 0.69 10.9 7.5 0.14 13.1 3.8 1.7 2 0 0 2 2 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Sox_N PF12444.8 CDI76496.1 - 1.7 9.8 6.8 0.75 11.0 1.1 2.3 2 0 0 2 2 2 0 Sox developmental protein N terminal DUF775 PF05603.12 CDI76496.1 - 1.8 8.1 9.3 0.28 10.7 5.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF775) Conotoxin PF02950.17 CDI76496.1 - 2.3 9.3 4.9 3.2 8.8 2.4 2.4 2 0 0 2 2 2 0 Conotoxin Suf PF05843.14 CDI76496.1 - 2.4 8.1 15.5 0.65 9.9 11.6 1.7 1 1 0 2 2 2 0 Suppressor of forked protein (Suf) MMR1 PF08505.10 CDI76496.1 - 2.5 8.3 10.9 0.58 10.4 6.3 2.0 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Spore_coat_CotO PF14153.6 CDI76496.1 - 3.2 7.6 14.8 0.31 10.9 10.4 1.6 2 0 0 2 2 2 0 Spore coat protein CotO SET PF00856.28 CDI76496.1 - 4.4 7.7 9.6 19 5.6 4.7 2.1 1 1 1 2 2 2 0 SET domain FlaG PF03646.15 CDI76496.1 - 5.1 7.3 17.6 5 7.4 14.9 2.2 2 0 0 2 2 2 0 FlaG protein DUF2722 PF10846.8 CDI76496.1 - 6.8 5.5 20.5 0.36 9.7 14.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Pkinase PF00069.25 CDI76498.1 - 2.8e-71 240.0 0.0 2.2e-70 237.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76498.1 - 2.9e-33 115.3 0.0 2.9e-27 95.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI76498.1 - 2e-29 98.9 3.4 3.9e-07 29.2 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDI76498.1 - 4.5e-24 84.7 0.3 1.6e-10 41.3 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI76498.1 - 4.6e-23 79.1 0.4 3.3e-06 26.6 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CDI76498.1 - 2.2e-21 74.3 4.1 4.9e-06 25.8 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CDI76498.1 - 1.7e-18 66.2 6.7 1.6e-06 27.9 0.4 4.7 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 CDI76498.1 - 6.4e-06 26.1 0.4 0.026 14.5 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Kdo PF06293.14 CDI76498.1 - 2.2e-05 23.9 0.0 5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI76498.1 - 7.8e-05 22.7 0.0 0.015 15.2 0.0 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family SPARC_Ca_bdg PF10591.9 CDI76498.1 - 0.00014 22.1 0.0 0.042 14.2 0.0 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDI76498.1 - 0.0011 19.3 0.0 0.065 13.6 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain DUF2267 PF10025.9 CDI76498.1 - 0.0021 18.3 0.1 0.18 12.1 0.0 2.8 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2267) Kinase-like PF14531.6 CDI76498.1 - 0.0025 17.2 0.0 0.89 8.8 0.0 2.5 3 0 0 3 3 3 2 Kinase-like DUF1840 PF08895.11 CDI76499.1 - 0.36 11.2 7.6 0.45 10.9 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) TERB2 PF15101.6 CDI76499.1 - 0.93 9.5 5.7 0.99 9.4 5.7 1.0 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FlxA PF14282.6 CDI76499.1 - 4.7 7.3 28.7 6.5 6.8 28.6 1.3 1 1 0 1 1 1 0 FlxA-like protein DUF572 PF04502.13 CDI76500.1 - 0.5 10.0 16.4 0.29 10.7 4.9 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) SR-25 PF10500.9 CDI76500.1 - 4.2 6.9 35.8 2.3 7.8 12.7 2.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SOUL PF04832.12 CDI76501.1 - 9.3e-29 100.7 0.0 9.9e-20 71.4 0.0 2.3 2 1 0 2 2 2 2 SOUL heme-binding protein SSP160 PF06933.11 CDI76501.1 - 7.3e-05 21.2 9.8 8.2e-05 21.0 9.8 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 ORC6 PF05460.13 CDI76501.1 - 0.00033 20.1 0.1 0.0004 19.8 0.1 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) DUF3602 PF12223.8 CDI76501.1 - 0.034 14.8 6.1 0.064 13.9 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3602) ATF7IP_BD PF16788.5 CDI76501.1 - 0.046 13.8 1.1 0.61 10.1 3.3 1.8 2 0 0 2 2 2 0 ATF-interacting protein binding domain Sporozoite_P67 PF05642.11 CDI76501.1 - 0.053 11.6 6.8 0.063 11.4 6.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Med3 PF11593.8 CDI76501.1 - 0.2 10.8 3.1 0.27 10.4 3.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SprA-related PF12118.8 CDI76501.1 - 0.83 8.7 7.9 1.1 8.3 7.9 1.1 1 0 0 1 1 1 0 SprA-related family Macoilin PF09726.9 CDI76501.1 - 2.7 6.4 5.7 3.2 6.2 5.7 1.1 1 0 0 1 1 1 0 Macoilin family RRM_1 PF00076.22 CDI76502.1 - 3.3e-06 26.8 0.0 5.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sporozoite_P67 PF05642.11 CDI76502.1 - 0.0014 16.8 1.2 0.0016 16.6 1.2 1.2 1 0 0 1 1 1 1 Sporozoite P67 surface antigen Lipase_GDSL PF00657.22 CDI76502.1 - 0.055 13.4 3.5 0.29 11.1 0.4 2.2 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase Peptidase_S64 PF08192.11 CDI76502.1 - 0.38 9.2 23.7 0.52 8.7 23.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI76502.1 - 6 7.1 39.6 0.061 13.6 12.2 2.9 2 1 1 3 3 3 0 Anti-sigma-K factor rskA Senescence_reg PF04520.13 CDI76502.1 - 6.1 7.7 33.4 0.26 12.1 25.9 2.3 1 1 1 2 2 2 0 Senescence regulator XPG_I PF00867.18 CDI76504.1 - 9.6e-24 83.6 0.1 9.6e-24 83.6 0.1 4.4 4 0 0 4 4 4 1 XPG I-region HHH_2 PF12826.7 CDI76504.1 - 0.018 15.1 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 CDI76504.1 - 0.1 13.2 0.0 0.1 13.2 0.0 4.4 4 0 0 4 4 4 0 5'-3' exonuclease, C-terminal SAM fold DUF3824 PF12868.7 CDI76505.1 - 0.052 14.2 23.0 0.25 12.0 10.4 2.6 1 1 1 2 2 2 0 Domain of unknwon function (DUF3824) Chloroa_b-bind PF00504.21 CDI76505.1 - 0.052 14.1 0.9 0.068 13.7 0.9 1.2 1 0 0 1 1 1 0 Chlorophyll A-B binding protein RskA PF10099.9 CDI76505.1 - 0.15 12.4 30.8 0.79 10.0 10.2 2.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA PAP2 PF01569.21 CDI76505.1 - 0.72 9.6 2.3 0.48 10.2 0.2 1.7 1 1 1 2 2 2 0 PAP2 superfamily Trp_oprn_chp PF09534.10 CDI76505.1 - 2.2 8.1 14.9 1 9.1 12.6 1.6 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2434 PF10361.9 CDI76505.1 - 2.5 7.0 6.8 3.7 6.5 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) SR-25 PF10500.9 CDI76505.1 - 2.6 7.6 40.4 2.3 7.8 19.8 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein BAF1_ABF1 PF04684.13 CDI76505.1 - 4.1 6.3 33.2 16 4.4 33.4 1.6 1 1 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SOBP PF15279.6 CDI76505.1 - 9.9 6.7 36.0 12 6.4 36.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Sin_N PF04801.13 CDI76506.1 - 2.2e-129 432.4 42.5 3.7e-125 418.5 32.2 3.0 1 1 2 3 3 3 3 Sin-like protein conserved region MethyTransf_Reg PF10119.9 CDI76508.1 - 0.042 14.6 0.2 2.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Predicted methyltransferase regulatory domain Ribosomal_60s PF00428.19 CDI76508.1 - 1.7 9.3 26.8 20 5.9 0.2 2.6 2 1 0 2 2 2 0 60s Acidic ribosomal protein YabA PF06156.13 CDI76509.1 - 0.081 13.6 8.3 0.32 11.7 8.3 2.0 1 1 0 1 1 1 0 Initiation control protein YabA DUF4407 PF14362.6 CDI76509.1 - 0.29 10.4 8.5 0.42 9.9 8.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.11 CDI76509.1 - 1.9 8.3 9.4 0.87 9.4 7.0 1.6 2 0 0 2 2 2 0 Phage minor structural protein GP20 Jnk-SapK_ap_N PF09744.9 CDI76509.1 - 3 8.0 13.2 1.3 9.2 10.6 1.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF5340 PF17275.2 CDI76509.1 - 3.3 7.9 10.3 7.5 6.8 2.9 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5340) Uso1_p115_C PF04871.13 CDI76509.1 - 9.3 6.6 13.5 35 4.8 11.3 2.3 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region TFIIA PF03153.13 CDI76512.1 - 0.021 14.9 29.6 0.035 14.1 29.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TraG-D_C PF12696.7 CDI76512.1 - 0.029 14.3 8.4 0.55 10.2 0.1 2.5 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG DUF2052 PF09747.9 CDI76512.1 - 0.032 14.4 9.5 0.057 13.6 9.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CobT PF06213.12 CDI76512.1 - 0.23 10.8 22.0 0.036 13.5 17.9 1.7 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Raftlin PF15250.6 CDI76512.1 - 0.46 9.2 7.1 0.61 8.8 7.1 1.2 1 0 0 1 1 1 0 Raftlin RR_TM4-6 PF06459.12 CDI76512.1 - 0.89 9.3 9.2 1.3 8.7 9.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI76512.1 - 0.91 8.5 7.2 1.5 7.8 7.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 RIFIN PF02009.16 CDI76512.1 - 1.2 9.0 10.6 1.7 8.5 10.6 1.2 1 0 0 1 1 1 0 Rifin Rrn6 PF10214.9 CDI76512.1 - 1.4 7.3 23.4 1.8 7.0 23.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TMEM214 PF10151.9 CDI76512.1 - 2.7 6.4 8.1 3.8 5.9 8.1 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator SWI-SNF_Ssr4 PF08549.10 CDI76512.1 - 5.6 5.5 16.7 6.8 5.2 16.7 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Lin-8 PF03353.15 CDI76512.1 - 5.9 6.4 18.4 24 4.4 0.0 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF4746 PF15928.5 CDI76512.1 - 6 6.2 9.1 5.4 6.4 7.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI76512.1 - 6.1 4.6 7.4 8.5 4.2 7.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Paf1 PF03985.13 CDI76512.1 - 8.4 5.3 15.4 16 4.4 15.4 1.4 1 0 0 1 1 1 0 Paf1 ALMT PF11744.8 CDI76512.1 - 8.7 5.0 8.8 12 4.6 8.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF572 PF04502.13 CDI76513.1 - 0.3 10.7 9.6 0.1 12.2 6.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF572) Exonuc_VII_L PF02601.15 CDI76513.1 - 5.3 6.5 37.3 0.61 9.6 25.0 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit AARP2CN PF08142.12 CDI76514.1 - 3.4e-07 30.2 6.5 3.4e-07 30.2 6.5 3.8 3 1 0 3 3 3 1 AARP2CN (NUC121) domain AAA_16 PF13191.6 CDI76514.1 - 0.0008 19.8 0.0 0.0008 19.8 0.0 3.0 3 1 0 3 3 2 1 AAA ATPase domain AAA PF00004.29 CDI76514.1 - 0.00097 19.6 3.0 0.00098 19.6 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI76514.1 - 0.0014 18.9 0.1 0.015 15.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain GTP_EFTU PF00009.27 CDI76514.1 - 0.0021 17.6 7.2 0.0024 17.4 4.3 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 CDI76514.1 - 0.011 16.0 0.7 0.04 14.3 0.0 2.3 2 0 0 2 2 2 0 RNA helicase KAP_NTPase PF07693.14 CDI76514.1 - 0.021 14.1 0.0 0.021 14.1 0.0 2.7 2 1 0 2 2 1 0 KAP family P-loop domain MMR_HSR1 PF01926.23 CDI76514.1 - 0.031 14.4 0.2 0.19 11.8 0.0 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_25 PF13481.6 CDI76514.1 - 0.033 13.8 0.0 0.22 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDI76514.1 - 0.046 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 CDI76514.1 - 0.19 11.5 0.1 0.19 11.5 0.1 5.0 3 2 1 5 5 2 0 AAA domain RskA PF10099.9 CDI76514.1 - 0.22 11.8 25.8 0.046 14.0 2.6 4.0 3 1 0 3 3 3 0 Anti-sigma-K factor rskA AAA_18 PF13238.6 CDI76514.1 - 0.25 11.9 0.0 0.25 11.9 0.0 3.5 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.6 CDI76514.1 - 0.28 11.4 0.0 0.28 11.4 0.0 3.1 2 0 0 2 2 2 0 AAA domain Helicase_C PF00271.31 CDI76515.1 - 0.017 15.5 0.0 0.017 15.5 0.0 2.8 2 2 1 3 3 3 0 Helicase conserved C-terminal domain PAT1 PF09770.9 CDI76515.1 - 0.41 8.9 28.7 0.64 8.2 28.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI76515.1 - 2.1 6.2 9.9 2.7 5.8 9.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF572 PF04502.13 CDI76515.1 - 3.4 7.2 15.3 0.39 10.3 8.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) CEP19 PF14933.6 CDI76515.1 - 7.4 6.8 13.4 22 5.3 13.4 1.8 1 0 0 1 1 1 0 CEP19-like protein Activator_LAG-3 PF11498.8 CDI76516.1 - 0.00098 18.2 0.6 0.00098 18.2 0.6 5.0 5 1 0 5 5 5 3 Transcriptional activator LAG-3 BAF1_ABF1 PF04684.13 CDI76517.1 - 0.11 11.5 25.8 0.037 13.1 15.1 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor AP2 PF00847.20 CDI76518.1 - 2.4e-05 24.5 1.0 4.4e-05 23.6 1.0 1.5 1 0 0 1 1 1 1 AP2 domain TFIIA PF03153.13 CDI76518.1 - 0.046 13.7 16.0 0.056 13.4 16.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI76518.1 - 0.094 12.3 7.3 0.064 12.9 2.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Chromo PF00385.24 CDI76519.1 - 1.3e-09 37.8 0.0 3.7e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Spt20 PF12090.8 CDI76525.1 - 0.0012 18.5 11.0 0.0012 18.5 10.0 1.6 2 0 0 2 2 2 1 Spt20 family DUF2722 PF10846.8 CDI76525.1 - 0.0021 17.1 8.1 0.0026 16.8 8.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI76525.1 - 0.017 15.5 0.4 0.16 12.2 0.5 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI76525.1 - 0.018 16.0 0.0 0.041 14.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FHIPEP PF00771.20 CDI76525.1 - 0.029 12.8 1.0 0.042 12.3 1.0 1.1 1 0 0 1 1 1 0 FHIPEP family TFIIA PF03153.13 CDI76525.1 - 0.19 11.7 13.5 0.27 11.2 13.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CDI76525.1 - 0.27 11.0 7.8 0.66 9.8 7.8 1.7 1 0 0 1 1 1 0 Septum formation initiator SID-1_RNA_chan PF13965.6 CDI76526.1 - 0.025 13.0 11.5 0.028 12.8 11.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF726 PF05277.12 CDI76526.1 - 0.033 13.1 1.4 0.033 13.1 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) CLN3 PF02487.17 CDI76526.1 - 0.044 12.8 16.0 0.055 12.5 16.0 1.2 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 CDI76526.1 - 0.045 12.1 22.4 0.056 11.7 22.4 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI76526.1 - 0.056 13.3 28.8 0.063 13.1 28.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI76526.1 - 0.13 11.4 21.5 0.17 11.1 21.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 CDI76526.1 - 0.16 10.8 18.4 0.2 10.5 18.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) AF-4 PF05110.13 CDI76526.1 - 0.17 9.9 34.9 0.19 9.8 34.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM60A PF15396.6 CDI76526.1 - 0.18 11.8 21.0 0.2 11.6 21.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MMR1 PF08505.10 CDI76526.1 - 0.21 11.9 31.5 0.28 11.4 31.5 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SelP_N PF04592.14 CDI76526.1 - 0.21 11.0 36.2 0.31 10.4 36.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CDC27 PF09507.10 CDI76526.1 - 0.29 10.5 29.2 0.34 10.2 29.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AAA_11 PF13086.6 CDI76526.1 - 0.31 10.8 22.8 0.36 10.6 22.8 1.1 1 0 0 1 1 1 0 AAA domain DUF4746 PF15928.5 CDI76526.1 - 0.39 10.1 20.5 0.48 9.8 20.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF913 PF06025.12 CDI76526.1 - 0.4 9.6 17.4 0.48 9.3 17.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nucleoside_tran PF01733.18 CDI76526.1 - 0.46 9.8 6.4 0.59 9.5 6.4 1.1 1 0 0 1 1 1 0 Nucleoside transporter XRN_M PF17846.1 CDI76526.1 - 0.47 9.4 17.8 0.6 9.0 17.8 1.3 1 0 0 1 1 1 0 Xrn1 helical domain IHABP4_N PF16174.5 CDI76526.1 - 0.48 11.0 29.9 0.61 10.7 29.9 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Spore_coat_CotO PF14153.6 CDI76526.1 - 0.5 10.3 33.4 0.67 9.8 33.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO CCSAP PF15748.5 CDI76526.1 - 0.5 10.5 30.9 0.61 10.2 30.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Caldesmon PF02029.15 CDI76526.1 - 0.56 8.9 27.8 0.63 8.7 27.8 1.0 1 0 0 1 1 1 0 Caldesmon Nop53 PF07767.11 CDI76526.1 - 0.61 9.4 34.2 0.69 9.2 34.2 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) FancD2 PF14631.6 CDI76526.1 - 0.65 7.3 15.2 0.75 7.1 15.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PPP4R2 PF09184.11 CDI76526.1 - 0.74 9.3 20.2 0.83 9.2 20.2 1.0 1 0 0 1 1 1 0 PPP4R2 VIR_N PF15912.5 CDI76526.1 - 0.87 9.1 17.9 0.99 8.9 17.9 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal O-antigen_lig PF13425.6 CDI76526.1 - 0.87 8.3 11.5 0.96 8.2 11.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SART-1 PF03343.13 CDI76526.1 - 0.88 8.0 28.1 0.94 8.0 28.1 1.0 1 0 0 1 1 1 0 SART-1 family UPF0564 PF10595.9 CDI76526.1 - 0.93 8.5 35.6 1 8.3 35.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 Spem1 PF15670.5 CDI76526.1 - 0.94 9.0 21.5 1.2 8.6 21.5 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 DREPP PF05558.12 CDI76526.1 - 1 9.2 12.9 1.3 8.9 12.9 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Raftlin PF15250.6 CDI76526.1 - 1.1 8.0 23.8 1.2 7.9 23.8 1.0 1 0 0 1 1 1 0 Raftlin RPOL_N PF14700.6 CDI76526.1 - 1.1 8.6 28.6 1.3 8.3 28.6 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DUF2052 PF09747.9 CDI76526.1 - 1.2 9.2 26.5 1.4 9.0 26.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Dicty_REP PF05086.12 CDI76526.1 - 1.3 6.9 25.8 1.7 6.5 25.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Endostatin PF06482.11 CDI76526.1 - 1.4 8.4 26.9 1.6 8.1 26.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 CDI76526.1 - 1.4 7.9 29.1 1.5 7.8 29.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF5427 PF10310.9 CDI76526.1 - 1.4 7.8 30.1 2 7.3 30.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2828 PF11443.8 CDI76526.1 - 1.5 6.9 25.1 1.7 6.7 25.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 CDI76526.1 - 1.5 7.7 33.1 1.8 7.4 33.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI76526.1 - 1.7 8.6 22.0 2 8.4 22.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI76526.1 - 1.7 6.7 28.3 1.9 6.5 28.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sec62 PF03839.16 CDI76526.1 - 1.8 8.1 21.0 2.1 7.8 21.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 TFIIA PF03153.13 CDI76526.1 - 2 8.3 62.8 3 7.7 62.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ALMT PF11744.8 CDI76526.1 - 2 7.1 24.3 2.1 7.1 24.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S64 PF08192.11 CDI76526.1 - 2.1 6.7 21.4 2.2 6.6 21.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 PNISR PF15996.5 CDI76526.1 - 2.1 8.5 32.9 2.7 8.2 32.9 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 CDI76526.1 - 2.3 6.9 40.3 2.8 6.6 40.3 1.0 1 0 0 1 1 1 0 Presenilin Alpha_GJ PF03229.13 CDI76526.1 - 2.3 8.8 18.3 2.9 8.4 18.3 1.1 1 0 0 1 1 1 0 Alphavirus glycoprotein J DUF1387 PF07139.11 CDI76526.1 - 2.4 7.8 27.3 2.9 7.5 27.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) GBP_C PF02841.14 CDI76526.1 - 2.4 7.5 36.4 3 7.2 36.4 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Spc7_N PF15402.6 CDI76526.1 - 2.5 6.3 23.5 2.8 6.1 23.5 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 V_ATPase_I PF01496.19 CDI76526.1 - 2.6 5.9 29.1 3 5.7 29.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S15 PF02129.18 CDI76526.1 - 2.6 7.5 22.5 3.1 7.3 22.5 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) FapA PF03961.13 CDI76526.1 - 2.8 6.4 16.6 3.3 6.2 16.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A HCO3_cotransp PF00955.21 CDI76526.1 - 2.8 6.6 12.9 3.3 6.4 12.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4045 PF13254.6 CDI76526.1 - 2.9 7.4 29.3 3.3 7.3 29.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) AI-2E_transport PF01594.16 CDI76526.1 - 2.9 7.0 3.4 3.4 6.7 3.4 1.1 1 0 0 1 1 1 0 AI-2E family transporter Hamartin PF04388.12 CDI76526.1 - 3.1 6.3 27.7 3.4 6.2 27.7 1.0 1 0 0 1 1 1 0 Hamartin protein Membralin PF09746.9 CDI76526.1 - 3.3 6.6 18.7 3.7 6.5 18.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein BORG_CEP PF14957.6 CDI76526.1 - 3.4 8.9 19.9 4.3 8.5 19.9 1.2 1 0 0 1 1 1 0 Cdc42 effector Macoilin PF09726.9 CDI76526.1 - 3.4 6.1 27.2 4 5.9 27.2 1.0 1 0 0 1 1 1 0 Macoilin family DUF4569 PF15133.6 CDI76526.1 - 3.8 7.1 26.3 5.3 6.7 26.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF572 PF04502.13 CDI76526.1 - 4.1 6.9 28.9 4.9 6.7 28.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDK5_activator PF03261.15 CDI76526.1 - 4.8 6.6 23.6 5.2 6.5 23.6 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Paramyxo_ncap PF00973.19 CDI76526.1 - 5 5.9 23.8 5.7 5.7 23.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF5094 PF17015.5 CDI76526.1 - 5 7.2 21.7 6.6 6.8 21.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) SOBP PF15279.6 CDI76526.1 - 5.1 7.6 26.2 5.9 7.4 26.2 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Asp-B-Hydro_N PF05279.11 CDI76526.1 - 6.1 6.8 22.8 6.9 6.7 22.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CAC1F_C PF16885.5 CDI76526.1 - 6.2 6.4 23.1 7.1 6.2 23.1 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Pannexin_like PF12534.8 CDI76526.1 - 7.2 5.6 22.5 8.8 5.3 22.5 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DcuA_DcuB PF03605.14 CDI76526.1 - 7.9 5.3 17.5 15 4.3 17.5 1.5 1 1 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter TCP PF03634.13 CDI76526.1 - 8.3 7.0 36.1 10 6.7 36.1 1.1 1 0 0 1 1 1 0 TCP family transcription factor SAPS PF04499.15 CDI76526.1 - 8.6 5.0 24.0 9.6 4.9 24.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MIIP PF15734.5 CDI76526.1 - 9.3 5.6 26.6 11 5.4 26.6 1.0 1 0 0 1 1 1 0 Migration and invasion-inhibitory NPR3 PF03666.13 CDI76526.1 - 9.4 4.9 27.2 11 4.6 27.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PAT1 PF09770.9 CDI76526.1 - 9.9 4.3 47.8 12 4.0 47.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DDRGK PF09756.9 CDI76526.1 - 10 5.7 38.2 13 5.3 38.2 1.1 1 0 0 1 1 1 0 DDRGK domain zf-B_box PF00643.24 CDI76527.1 - 0.00037 20.6 6.2 0.00071 19.7 6.2 1.4 1 0 0 1 1 1 1 B-box zinc finger ABC2_membrane_2 PF12679.7 CDI76529.1 - 0.004 16.5 3.9 0.079 12.2 0.1 2.7 3 0 0 3 3 3 1 ABC-2 family transporter protein Connexin PF00029.19 CDI76529.1 - 0.0052 16.6 7.9 0.0052 16.6 7.9 2.4 3 0 0 3 3 2 1 Connexin Velvet PF11754.8 CDI76529.1 - 0.0055 16.7 16.8 0.064 13.2 11.6 2.2 2 0 0 2 2 2 1 Velvet factor PIP5K PF01504.18 CDI76529.1 - 0.017 14.3 15.1 0.14 11.4 10.1 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase SDA1 PF05285.12 CDI76529.1 - 0.019 14.4 33.3 0.31 10.4 0.6 2.1 2 0 0 2 2 2 0 SDA1 Allexi_40kDa PF05549.11 CDI76529.1 - 0.024 14.1 0.3 0.024 14.1 0.3 3.2 3 1 1 4 4 2 0 Allexivirus 40kDa protein SpoIIP PF07454.11 CDI76529.1 - 0.028 13.9 0.3 0.028 13.9 0.3 2.8 2 1 1 3 3 2 0 Stage II sporulation protein P (SpoIIP) EPL1 PF10513.9 CDI76529.1 - 0.037 14.4 0.5 0.037 14.4 0.5 2.9 2 1 0 2 2 1 0 Enhancer of polycomb-like SAPS PF04499.15 CDI76529.1 - 0.089 11.6 25.3 0.69 8.6 0.0 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein SOBP PF15279.6 CDI76529.1 - 0.2 12.2 21.7 1.2 9.7 11.5 2.3 2 0 0 2 2 2 0 Sine oculis-binding protein MecA PF05389.12 CDI76529.1 - 0.29 10.7 0.0 0.29 10.7 0.0 3.0 2 1 0 2 2 1 0 Negative regulator of genetic competence (MecA) OATP PF03137.20 CDI76529.1 - 0.3 9.3 10.9 1.4 7.1 1.3 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family BAF1_ABF1 PF04684.13 CDI76529.1 - 0.36 9.8 24.9 1.2 8.1 0.1 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor EOS1 PF12326.8 CDI76529.1 - 0.51 10.3 9.1 15 5.4 0.0 2.4 2 0 0 2 2 2 0 N-glycosylation protein CAC1F_C PF16885.5 CDI76529.1 - 0.85 9.2 23.0 2.3 7.8 1.9 2.3 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term DUF2828 PF11443.8 CDI76529.1 - 0.86 7.6 22.1 0.87 7.6 13.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Spem1 PF15670.5 CDI76529.1 - 1.1 8.8 18.0 9.6 5.7 13.6 2.3 2 0 0 2 2 2 0 Spermatid maturation protein 1 Spore_YhcN_YlaJ PF09580.10 CDI76529.1 - 1.1 9.3 0.0 1.1 9.3 0.0 2.5 2 1 0 2 2 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Peroxin-3 PF04882.12 CDI76529.1 - 1.4 7.8 29.4 1.7 7.6 17.9 2.3 2 0 0 2 2 2 0 Peroxin-3 Otopetrin PF03189.13 CDI76529.1 - 1.5 7.6 13.1 7.7 5.2 9.7 2.2 2 0 0 2 2 2 0 Otopetrin ThiD2 PF17792.1 CDI76529.1 - 1.5 9.3 18.8 0.39 11.2 1.0 2.5 2 0 0 2 2 2 0 ThiD2 family eIF-3_zeta PF05091.12 CDI76529.1 - 1.7 7.5 32.8 0.88 8.5 1.4 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF45 PF01863.17 CDI76529.1 - 1.8 8.6 19.8 6.6 6.7 10.8 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF45 Na_trans_assoc PF06512.13 CDI76529.1 - 2 8.6 22.0 2.9 8.1 0.5 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated Caldesmon PF02029.15 CDI76529.1 - 2.1 7.0 40.6 0.15 10.8 25.6 2.7 3 0 0 3 3 3 0 Caldesmon DUF2126 PF09899.9 CDI76529.1 - 2.2 6.2 17.0 5.5 4.9 0.2 2.2 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) SPX PF03105.19 CDI76529.1 - 2.4 8.0 24.0 6.3 6.6 0.2 2.6 3 0 0 3 3 3 0 SPX domain Presenilin PF01080.17 CDI76529.1 - 4.8 5.8 38.9 1.8 7.3 3.3 2.2 2 0 0 2 2 2 0 Presenilin Folate_carrier PF01770.18 CDI76529.1 - 5.5 5.6 17.1 0.9 8.2 1.4 2.5 2 0 0 2 2 2 0 Reduced folate carrier RRN3 PF05327.11 CDI76529.1 - 6.1 5.3 25.1 1.9 7.0 16.4 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Neur_chan_memb PF02932.16 CDI76529.1 - 7.8 6.5 24.0 5.8 6.9 1.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TT_ORF1 PF02956.14 CDI76529.1 - 8.4 4.9 12.5 0.94 8.1 4.8 2.0 2 0 0 2 2 2 0 TT viral orf 1 Hamartin PF04388.12 CDI76529.1 - 8.6 4.9 27.3 3.1 6.3 0.4 2.1 2 0 0 2 2 2 0 Hamartin protein SID-1_RNA_chan PF13965.6 CDI76529.1 - 8.8 4.6 14.8 16 3.8 10.3 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF3292 PF11696.8 CDI76529.1 - 9.8 4.4 25.5 4.5 5.5 3.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) HCO3_cotransp PF00955.21 CDI76529.1 - 9.9 4.9 10.3 0.36 9.6 2.2 2.0 2 0 0 2 2 2 0 HCO3- transporter family PNISR PF15996.5 CDI76529.1 - 9.9 6.4 50.5 3.2 8.0 35.0 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Methyltransf_16 PF10294.9 CDI76530.1 - 1.5e-11 44.4 0.0 1.2e-05 25.1 0.0 3.9 4 0 0 4 4 4 3 Lysine methyltransferase PAT1 PF09770.9 CDI76531.1 - 0.22 9.7 43.6 0.31 9.3 43.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Trp_oprn_chp PF09534.10 CDI76531.1 - 1.2 9.0 23.1 2.7 7.8 3.4 3.5 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4366 PF14283.6 CDI76531.1 - 1.5 8.9 21.0 1.4 8.9 2.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) DUF5427 PF10310.9 CDI76531.1 - 1.9 7.3 30.3 2.7 6.9 30.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SARAF PF06682.12 CDI76531.1 - 4.5 6.8 25.1 1.7 8.2 22.1 1.7 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Mob1_phocein PF03637.17 CDI76532.1 - 9.6e-13 48.5 0.7 2e-10 40.9 0.0 2.2 2 0 0 2 2 2 1 Mob1/phocein family RskA PF10099.9 CDI76532.1 - 0.00033 21.0 11.7 0.0021 18.4 3.6 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI76532.1 - 0.0011 19.9 6.9 0.13 13.3 1.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) RXLR PF16810.5 CDI76532.1 - 0.004 17.6 2.0 0.0052 17.2 0.1 1.9 1 1 1 2 2 2 1 RXLR phytopathogen effector protein, Avirulence activity Folliculin PF11704.8 CDI76532.1 - 0.0071 16.3 10.3 0.016 15.1 1.2 2.2 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport BIRC6 PF12356.8 CDI76532.1 - 0.03 13.8 1.8 0.04 13.3 0.4 1.8 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 Presenilin PF01080.17 CDI76532.1 - 0.035 12.9 6.9 0.052 12.3 6.9 1.2 1 0 0 1 1 1 0 Presenilin DUF5327 PF17261.2 CDI76532.1 - 0.04 14.6 14.3 0.67 10.7 2.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5327) BPA_C PF18040.1 CDI76532.1 - 0.042 13.8 0.2 0.25 11.3 0.0 2.0 2 0 0 2 2 2 0 beta porphyranase A C-terminal G0-G1_switch_2 PF15103.6 CDI76532.1 - 0.062 13.7 9.7 1.5 9.3 1.1 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 TERB2 PF15101.6 CDI76532.1 - 1.1 9.3 16.6 0.31 11.1 1.2 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 FHIPEP PF00771.20 CDI76532.1 - 1.2 7.6 6.7 0.81 8.1 0.7 2.0 2 0 0 2 2 2 0 FHIPEP family DUF5066 PF16728.5 CDI76532.1 - 1.6 8.0 5.8 0.18 11.1 1.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5066) DUF2269 PF10027.9 CDI76532.1 - 1.7 8.7 4.2 0.4 10.7 0.6 1.7 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) EIIBC-GUT_N PF03612.14 CDI76532.1 - 1.7 8.3 8.6 2.9 7.6 0.9 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AAA_23 PF13476.6 CDI76532.1 - 1.8 9.0 13.2 4.3 7.8 13.3 1.4 1 1 0 1 1 1 0 AAA domain TFIIA PF03153.13 CDI76532.1 - 2.1 8.3 33.0 0.23 11.4 8.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI76532.1 - 2.2 8.0 7.6 8.8 6.0 0.9 2.1 2 0 0 2 2 2 0 Connexin EPL1 PF10513.9 CDI76532.1 - 3.3 8.1 14.2 0.69 10.3 0.4 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like RED_N PF07808.13 CDI76532.1 - 3.3 7.2 17.1 1 8.9 7.1 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region DUF2721 PF11026.8 CDI76532.1 - 4.2 7.3 5.6 0.73 9.7 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) CPSF100_C PF13299.6 CDI76532.1 - 4.4 7.5 13.9 2.1 8.5 0.6 2.4 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal EOS1 PF12326.8 CDI76532.1 - 7 6.5 6.8 21 5.0 1.4 2.2 2 0 0 2 2 2 0 N-glycosylation protein DUF5421 PF17458.2 CDI76532.1 - 7.6 5.8 20.0 0.4 10.0 3.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5421) ATAD4 PF15321.6 CDI76532.1 - 8.2 7.8 9.4 29 6.1 3.0 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Hus1 PF04005.12 CDI76533.1 - 1e-10 41.2 0.1 7e-08 31.9 0.0 2.1 1 1 1 2 2 2 2 Hus1-like protein GCP_C_terminal PF04130.13 CDI76534.1 - 4.1e-24 85.6 4.8 4.1e-24 85.6 4.8 2.4 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal TerC PF03741.16 CDI76534.1 - 0.042 13.5 0.0 2.5 7.8 0.0 3.3 3 0 0 3 3 3 0 Integral membrane protein TerC family DUF2722 PF10846.8 CDI76535.1 - 0.0011 18.0 4.0 0.0011 18.0 4.0 5.3 3 1 2 5 5 5 2 Protein of unknown function (DUF2722) Sin_N PF04801.13 CDI76535.1 - 0.0011 18.2 4.2 0.0011 18.2 4.2 3.0 3 1 0 3 3 3 1 Sin-like protein conserved region VHS PF00790.19 CDI76535.1 - 0.0052 16.6 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 VHS domain K_channel_TID PF07941.11 CDI76535.1 - 0.015 15.8 6.8 0.015 15.8 6.8 11.0 8 3 3 11 11 11 0 Potassium channel Kv1.4 tandem inactivation domain SAGA-Tad1 PF12767.7 CDI76535.1 - 8.2 6.1 29.4 2.5 7.8 4.2 3.5 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit Nop14 PF04147.12 CDI76536.1 - 0.16 10.2 22.2 0.24 9.6 22.2 1.3 1 0 0 1 1 1 0 Nop14-like family SET PF00856.28 CDI76536.1 - 0.21 11.9 6.5 0.57 10.5 0.0 2.6 2 1 0 2 2 2 0 SET domain SDA1 PF05285.12 CDI76536.1 - 2.1 7.7 26.6 3.3 7.0 26.6 1.3 1 0 0 1 1 1 0 SDA1 MT PF12777.7 CDI76537.1 - 0.42 9.6 5.0 6 5.8 0.3 2.2 1 1 1 2 2 2 0 Microtubule-binding stalk of dynein motor DUF4551 PF15087.6 CDI76537.1 - 4.2 6.1 17.0 5.6 5.7 17.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF2681 PF10883.8 CDI76539.1 - 0.022 15.1 0.1 0.022 15.1 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) MAS20 PF02064.15 CDI76539.1 - 0.14 12.3 4.9 0.19 11.8 0.0 2.6 2 0 0 2 2 2 0 MAS20 protein import receptor Draxin PF15550.6 CDI76539.1 - 4.8 7.0 9.1 0.74 9.6 0.1 2.5 3 0 0 3 3 3 0 Draxin Wtap PF17098.5 CDI76540.1 - 4e-44 150.3 0.0 1.6e-43 148.3 0.0 1.8 2 0 0 2 2 2 1 WTAP/Mum2p family ATG16 PF08614.11 CDI76540.1 - 0.0026 18.0 14.7 0.0026 18.0 14.7 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF4795 PF16043.5 CDI76540.1 - 0.095 12.3 4.0 0.08 12.5 2.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) GAS PF13851.6 CDI76540.1 - 0.1 11.9 10.6 0.28 10.5 10.6 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 CDI76540.1 - 0.29 11.8 6.8 0.21 12.3 1.7 2.8 1 1 1 2 2 2 0 Initiation control protein YabA GIT_CC PF16559.5 CDI76540.1 - 0.6 10.0 6.0 2.7 7.9 0.9 3.1 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.11 CDI76540.1 - 0.61 8.9 9.7 1.3 7.8 9.7 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Phage_GP20 PF06810.11 CDI76540.1 - 1.6 8.5 10.4 2.3 8.0 0.4 2.8 1 1 2 3 3 3 0 Phage minor structural protein GP20 NYD-SP28_assoc PF14775.6 CDI76540.1 - 1.7 8.8 8.4 1.2 9.3 0.2 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain CCDC-167 PF15188.6 CDI76540.1 - 2 8.8 6.6 6 7.3 3.6 2.7 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 PT PF04886.12 CDI76540.1 - 5.3 6.7 10.6 0.076 12.6 3.0 2.0 2 0 0 2 2 2 0 PT repeat NUC173 PF08161.12 CDI76541.1 - 7.1e-17 61.7 0.1 7.1e-17 61.7 0.1 4.3 5 0 0 5 5 5 1 NUC173 domain Vpu PF00558.19 CDI76541.1 - 0.44 10.4 2.1 0.88 9.4 1.1 2.1 1 1 0 1 1 1 0 Vpu protein DUF3458_C PF17432.2 CDI76542.1 - 3.4e-82 276.4 0.4 4.8e-82 275.9 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 CDI76542.1 - 6.8e-45 153.3 0.1 1.1e-44 152.6 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 CDI76542.1 - 5.3e-19 68.5 0.0 9.7e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 CDI76542.1 - 1.8e-10 41.3 0.0 2.9e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 CDI76542.1 - 0.042 14.3 2.1 0.91 9.9 2.1 2.7 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Hydrolase_4 PF12146.8 CDI76543.1 - 0.00049 19.4 0.2 0.085 12.1 0.0 2.9 1 1 0 2 2 2 2 Serine aminopeptidase, S33 GET2 PF08690.10 CDI76544.1 - 0.031 13.9 0.2 0.031 13.9 0.2 3.0 3 0 0 3 3 3 0 GET complex subunit GET2 Lactamase_B_2 PF12706.7 CDI76545.1 - 3.4e-07 30.0 0.0 4.7e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Macoilin PF09726.9 CDI76546.1 - 0.048 12.2 38.6 0.052 12.1 38.6 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI76546.1 - 0.2 11.6 55.0 0.25 11.3 55.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI76546.1 - 0.7 8.1 41.9 0.71 8.1 41.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RAP1 PF07218.11 CDI76546.1 - 0.97 7.6 17.4 1.1 7.5 17.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Lin-8 PF03353.15 CDI76546.1 - 1.1 8.7 41.2 1.4 8.4 41.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI76546.1 - 1.9 5.5 42.4 2.2 5.3 42.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S64 PF08192.11 CDI76546.1 - 3.1 6.2 39.2 3.6 6.0 39.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 Herpes_pp85 PF04637.12 CDI76546.1 - 5 5.4 13.7 5.9 5.2 13.7 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Cwf_Cwc_15 PF04889.12 CDI76546.1 - 5.5 6.7 34.9 7.1 6.3 34.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DDRGK PF09756.9 CDI76546.1 - 5.6 6.5 34.8 8.4 5.9 34.8 1.3 1 0 0 1 1 1 0 DDRGK domain Apt1 PF10351.9 CDI76546.1 - 5.7 5.7 36.3 8 5.2 36.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain CNDH2_C PF16858.5 CDI76546.1 - 6 6.6 30.1 7.3 6.4 30.1 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SPX PF03105.19 CDI76546.1 - 6.1 6.6 40.6 6.8 6.5 40.6 1.0 1 0 0 1 1 1 0 SPX domain Plasmodium_Vir PF05795.11 CDI76546.1 - 8.5 5.7 25.7 13 5.1 25.7 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Lactamase_B_4 PF13691.6 CDI76547.1 - 6.9e-06 25.7 0.0 1.8e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 tRNase Z endonuclease SUIM_assoc PF16619.5 CDI76547.1 - 0.0028 17.7 4.9 0.0028 17.7 4.9 2.2 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 N-SET PF11764.8 CDI76547.1 - 0.034 14.2 1.4 0.034 14.2 1.4 2.3 3 0 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component N TFIIA PF03153.13 CDI76547.1 - 0.2 11.6 7.6 0.26 11.2 7.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 CDI76547.1 - 2.8 6.4 9.3 3.7 6.0 9.3 1.1 1 0 0 1 1 1 0 Utp14 protein SOG2 PF10428.9 CDI76547.1 - 5.6 6.1 18.6 7.6 5.6 18.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF1645 PF07816.11 CDI76547.1 - 8.2 7.0 16.6 0.21 12.1 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1645) SPX PF03105.19 CDI76549.1 - 0.0002 21.4 5.1 0.00032 20.8 5.1 1.4 1 1 0 1 1 1 1 SPX domain Band_3_cyto PF07565.13 CDI76549.1 - 0.11 12.3 10.3 0.18 11.6 10.3 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Otopetrin PF03189.13 CDI76549.1 - 0.12 11.1 1.7 0.12 11.1 1.7 1.2 1 0 0 1 1 1 0 Otopetrin DUF3446 PF11928.8 CDI76549.1 - 0.16 12.3 13.1 0.19 12.0 5.8 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain CDC45 PF02724.14 CDI76549.1 - 0.21 9.8 10.2 0.33 9.2 10.2 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.13 CDI76549.1 - 0.55 10.2 35.3 0.88 9.5 35.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OATP PF03137.20 CDI76549.1 - 0.82 7.9 5.8 1.2 7.4 5.8 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SR-25 PF10500.9 CDI76549.1 - 2.1 7.9 25.0 0.13 11.8 5.2 2.7 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI76549.1 - 2.1 7.0 20.1 1.4 7.6 18.6 1.4 2 0 0 2 2 2 0 Presenilin SpoIIP PF07454.11 CDI76549.1 - 2.4 7.5 13.9 3.6 7.0 13.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spore_coat_CotO PF14153.6 CDI76549.1 - 4.5 7.2 23.9 7.2 6.5 23.9 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF4228 PF14009.6 CDI76549.1 - 4.6 7.6 11.6 13 6.2 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) NARP1 PF12569.8 CDI76549.1 - 6.8 5.5 14.7 9.1 5.1 14.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 XRN_M PF17846.1 CDI76549.1 - 7.6 5.4 10.1 11 4.9 10.1 1.1 1 0 0 1 1 1 0 Xrn1 helical domain SLC12 PF03522.15 CDI76549.1 - 8 5.4 16.5 12 4.8 16.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI76549.1 - 8.7 4.5 28.7 11 4.1 28.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF913 PF06025.12 CDI76549.1 - 8.8 5.2 11.2 14 4.5 10.6 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) TFIIA PF03153.13 CDI76550.1 - 4.5e-05 23.6 34.7 4.5e-05 23.6 34.7 14.6 8 2 1 13 13 13 6 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI76550.1 - 0.0047 17.6 26.2 0.0047 17.6 26.2 21.3 16 7 4 21 21 21 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI76550.1 - 0.013 14.5 0.1 0.013 14.5 0.1 19.8 17 3 1 18 18 18 0 Protein of unknown function (DUF2722) SPX PF03105.19 CDI76550.1 - 0.037 14.0 0.0 0.037 14.0 0.0 13.6 7 3 2 9 9 9 0 SPX domain MEF2_binding PF09047.10 CDI76551.1 - 0.5 10.2 9.8 0.89 9.4 0.7 4.3 1 1 2 3 3 3 0 MEF2 binding GYF_2 PF14237.6 CDI76553.1 - 0.0065 16.3 0.0 0.024 14.4 0.0 2.0 1 0 0 1 1 1 1 GYF domain 2 DUF936 PF06075.12 CDI76553.1 - 4.1 6.2 30.8 0.15 10.9 23.0 1.9 2 0 0 2 2 2 0 Plant protein of unknown function (DUF936) ThiF PF00899.21 CDI76554.1 - 1.2e-44 152.5 0.3 3.4e-44 151.0 0.0 2.0 2 1 0 2 2 2 1 ThiF family Shikimate_DH PF01488.20 CDI76554.1 - 0.047 13.8 0.0 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Rhodanese PF00581.20 CDI76554.1 - 0.17 12.5 0.0 2.3 8.8 0.0 2.5 1 1 0 1 1 1 0 Rhodanese-like domain DUF4614 PF15391.6 CDI76554.1 - 0.37 10.8 5.5 0.58 10.1 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) ANAPC_CDC26 PF10471.9 CDI76554.1 - 5.7 7.8 6.1 5.2 8.0 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Presenilin PF01080.17 CDI76555.1 - 0.0027 16.5 10.2 0.13 11.0 0.2 2.1 2 0 0 2 2 2 2 Presenilin Spt20 PF12090.8 CDI76555.1 - 0.0082 15.8 14.9 0.0082 15.8 14.9 2.3 2 0 0 2 2 2 1 Spt20 family Cupin_8 PF13621.6 CDI76555.1 - 0.033 13.9 0.1 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 Cupin-like domain SOG2 PF10428.9 CDI76555.1 - 0.047 12.9 21.2 0.067 12.4 15.0 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein EPL1 PF10513.9 CDI76555.1 - 0.1 12.9 9.8 0.75 10.2 2.5 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Ndc1_Nup PF09531.10 CDI76555.1 - 0.44 9.2 16.5 1.6 7.3 0.9 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 CDI76555.1 - 0.66 9.8 26.4 2.7 7.8 0.5 2.1 2 0 0 2 2 2 0 SPX domain Neur_chan_memb PF02932.16 CDI76555.1 - 1.8 8.5 8.5 2 8.4 0.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI76555.1 - 2.3 7.3 8.2 5 6.1 8.2 1.5 1 0 0 1 1 1 0 Drosophila roughex protein CTU2 PF10288.9 CDI76555.1 - 3.6 7.8 15.5 1.1 9.5 3.5 2.5 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 SARAF PF06682.12 CDI76555.1 - 4.4 6.9 17.3 8.8 5.9 0.3 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis AUDH_Cupin PF18637.1 CDI76556.1 - 0.35 10.9 6.3 0.64 10.0 6.3 1.4 1 0 0 1 1 1 0 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain Dsh_C PF12316.8 CDI76559.1 - 0.00068 20.1 15.1 0.00068 20.1 15.1 2.6 2 1 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal Herpes_capsid PF06112.11 CDI76559.1 - 0.0087 16.1 3.2 0.0087 16.1 3.2 4.0 4 1 0 4 4 4 1 Gammaherpesvirus capsid protein Ribosomal_S2 PF00318.20 CDI76559.1 - 0.11 11.8 0.0 0.11 11.8 0.0 3.1 4 1 0 4 4 4 0 Ribosomal protein S2 SR-25 PF10500.9 CDI76559.1 - 6.4 6.3 64.6 0.58 9.7 30.5 3.1 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein CTP_transf_like PF01467.26 CDI76561.1 - 3.4e-12 46.8 6.6 4.9e-09 36.5 6.5 2.7 1 1 0 1 1 1 1 Cytidylyltransferase-like Presenilin PF01080.17 CDI76561.1 - 0.0027 16.5 9.6 0.0027 16.5 9.6 2.1 2 1 0 2 2 2 1 Presenilin Tankyrase_bdg_C PF15327.6 CDI76561.1 - 0.0056 17.2 0.3 0.0056 17.2 0.3 2.5 2 0 0 2 2 2 1 Tankyrase binding protein C terminal domain BAF1_ABF1 PF04684.13 CDI76561.1 - 0.013 14.6 9.6 0.012 14.7 4.0 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DUF913 PF06025.12 CDI76561.1 - 0.025 13.5 6.6 0.019 14.0 3.8 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SLC12 PF03522.15 CDI76561.1 - 0.034 13.2 12.3 0.062 12.3 10.1 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Tim54 PF11711.8 CDI76561.1 - 0.15 10.8 12.2 0.54 9.0 9.3 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 CDI76561.1 - 0.19 11.8 14.2 0.56 10.2 9.6 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI76561.1 - 0.2 9.9 10.4 0.018 13.4 5.3 1.7 2 0 0 2 2 2 0 CDC45-like protein O-antigen_lig PF13425.6 CDI76561.1 - 0.29 9.9 4.7 0.43 9.3 4.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2722 PF10846.8 CDI76561.1 - 0.79 8.6 0.0 0.79 8.6 0.0 3.3 2 2 1 3 3 1 0 Protein of unknown function (DUF2722) Membralin PF09746.9 CDI76561.1 - 1.3 8.0 5.6 2.3 7.2 5.6 1.4 1 0 0 1 1 1 0 Tumour-associated protein NPR3 PF03666.13 CDI76561.1 - 1.5 7.5 13.6 0.18 10.5 8.7 1.9 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CCDC53 PF10152.9 CDI76561.1 - 2.4 8.6 25.4 17 5.8 19.3 2.6 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex SpoIIP PF07454.11 CDI76561.1 - 3.1 7.2 15.1 0.29 10.5 10.2 1.8 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Lin-8 PF03353.15 CDI76561.1 - 4.7 6.7 27.2 5 6.6 0.4 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Peptidase_S49_N PF08496.10 CDI76561.1 - 6 6.9 11.6 0.95 9.5 6.5 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 CDI76561.1 - 6.5 5.0 5.3 6.9 5.0 2.5 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI76561.1 - 6.6 5.7 11.0 0.81 8.7 6.7 1.6 2 0 0 2 2 2 0 CLN3 protein LAM_C PF12544.8 CDI76561.1 - 8.3 6.6 9.2 76 3.5 0.0 2.4 2 0 0 2 2 2 0 Lysine-2,3-aminomutase Pro_CA PF00484.19 CDI76561.1 - 9.9 6.4 10.2 6.5 7.0 0.1 2.5 2 0 0 2 2 2 0 Carbonic anhydrase Ldh_1_C PF02866.18 CDI76562.1 - 0.008 16.1 0.8 0.008 16.1 0.8 2.7 2 1 1 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Spt20 PF12090.8 CDI76562.1 - 0.014 15.0 2.2 0.014 15.0 2.2 4.7 2 1 1 3 3 3 0 Spt20 family DUF702 PF05142.12 CDI76562.1 - 0.016 15.7 0.8 0.016 15.7 0.8 4.3 2 1 0 2 2 2 0 Domain of unknown function (DUF702) Ribosomal_60s PF00428.19 CDI76562.1 - 0.75 10.4 24.7 2.4 8.8 8.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Asp-B-Hydro_N PF05279.11 CDI76562.1 - 6.2 6.8 19.5 4 7.4 12.5 2.4 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region RskA PF10099.9 CDI76563.1 - 1.9e-05 25.0 0.0 1.9e-05 25.0 0.0 2.1 1 1 1 2 2 2 1 Anti-sigma-K factor rskA N6_N4_Mtase PF01555.18 CDI76563.1 - 0.0016 18.2 0.0 0.0023 17.7 0.0 1.4 1 1 0 1 1 1 1 DNA methylase DUF2428 PF10350.9 CDI76563.1 - 0.073 12.3 8.2 0.13 11.5 8.2 1.4 1 1 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) UMP1 PF05348.11 CDI76563.1 - 0.83 9.9 14.6 1 9.6 4.4 2.3 2 0 0 2 2 2 0 Proteasome maturation factor UMP1 Peptidase_S49_N PF08496.10 CDI76563.1 - 0.95 9.5 9.5 0.075 13.1 0.5 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal CLN3 PF02487.17 CDI76563.1 - 4.8 6.1 6.0 5.7 5.9 6.0 1.3 1 0 0 1 1 1 0 CLN3 protein RtcB PF01139.17 CDI76564.1 - 4.4e-116 388.4 0.9 7.5e-103 344.9 0.0 5.2 4 2 1 5 5 5 2 tRNA-splicing ligase RtcB SpoIIIAH PF12685.7 CDI76565.1 - 0.082 12.7 7.6 0.1 12.4 7.6 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Zip PF02535.22 CDI76565.1 - 0.26 10.4 2.9 0.3 10.3 2.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI76565.1 - 0.36 9.6 7.9 0.38 9.5 7.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DMAP_binding PF06464.11 CDI76565.1 - 0.37 11.6 4.9 0.6 10.9 4.9 1.3 1 0 0 1 1 1 0 DMAP1-binding Domain Presenilin PF01080.17 CDI76565.1 - 0.37 9.5 6.4 0.44 9.3 6.4 1.1 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 CDI76565.1 - 0.42 8.9 9.5 0.42 8.9 9.5 1.0 1 0 0 1 1 1 0 Menin Apt1 PF10351.9 CDI76565.1 - 0.53 9.1 17.6 0.57 9.0 17.6 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI76565.1 - 0.69 8.4 21.6 0.71 8.4 21.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF1180 PF06679.12 CDI76565.1 - 0.88 10.0 6.0 1.2 9.6 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) GEMIN8 PF15348.6 CDI76565.1 - 1.2 9.4 7.1 1.3 9.3 7.1 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Peroxin-3 PF04882.12 CDI76565.1 - 1.6 7.6 10.3 1.7 7.5 10.3 1.1 1 0 0 1 1 1 0 Peroxin-3 YMF19 PF02326.15 CDI76565.1 - 2.1 9.2 4.7 3.8 8.4 4.7 1.5 1 1 0 1 1 1 0 Plant ATP synthase F0 DUF5423 PF17461.2 CDI76565.1 - 2.1 7.1 19.8 2.5 6.9 19.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) SPX PF03105.19 CDI76565.1 - 2.6 7.8 16.4 2.8 7.8 16.4 1.1 1 0 0 1 1 1 0 SPX domain Sec3_C PF09763.9 CDI76565.1 - 2.7 6.2 8.8 2.7 6.3 8.8 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 RAP1 PF07218.11 CDI76565.1 - 3.4 5.8 27.7 4.1 5.6 27.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ashwin PF15323.6 CDI76565.1 - 6.3 6.8 14.9 7.7 6.5 14.9 1.2 1 0 0 1 1 1 0 Developmental protein PP2C_C PF07830.13 CDI76566.1 - 0.021 15.3 0.4 1.3 9.5 0.0 3.9 4 0 0 4 4 4 0 Protein serine/threonine phosphatase 2C, C-terminal domain GCV_T PF01571.21 CDI76567.1 - 1.6e-05 24.5 0.0 0.09 12.1 0.0 3.2 3 0 0 3 3 3 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CDI76567.1 - 0.0035 17.2 0.0 0.0083 16.0 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Nrap_D5 PF17406.2 CDI76568.1 - 0.0077 16.0 0.5 0.011 15.5 0.5 1.2 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 DUF3499 PF12005.8 CDI76568.1 - 0.011 16.3 0.3 0.014 16.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) Med15 PF09606.10 CDI76568.1 - 0.014 14.1 15.3 0.015 14.0 15.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal N1221 PF07923.13 CDI76568.1 - 0.016 14.4 1.6 0.018 14.2 1.6 1.1 1 0 0 1 1 1 0 N1221-like protein STAC2_u1 PF16664.5 CDI76568.1 - 0.028 14.9 0.3 0.037 14.5 0.3 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Herpes_UL3 PF03369.13 CDI76568.1 - 0.039 14.5 0.9 0.047 14.2 0.9 1.2 1 0 0 1 1 1 0 Herpesvirus UL3 protein Spt20 PF12090.8 CDI76568.1 - 0.048 13.3 15.8 0.053 13.1 15.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI76568.1 - 0.074 14.0 2.2 0.084 13.8 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CsiV PF10972.8 CDI76568.1 - 0.081 12.6 5.2 0.1 12.3 5.2 1.1 1 0 0 1 1 1 0 Peptidoglycan-binding protein, CsiV DUF2722 PF10846.8 CDI76568.1 - 0.082 11.8 12.3 0.1 11.5 12.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) UPF0560 PF10577.9 CDI76568.1 - 0.12 10.8 4.3 0.11 11.0 4.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CrgA PF06781.12 CDI76568.1 - 0.13 12.3 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 Cell division protein CrgA Med3 PF11593.8 CDI76568.1 - 0.17 11.0 14.7 0.21 10.8 14.7 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TFIIA PF03153.13 CDI76568.1 - 0.21 11.6 13.6 0.22 11.5 13.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RAB3GAP2_N PF14655.6 CDI76568.1 - 1.4 8.1 8.8 1.8 7.7 8.6 1.2 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF5408 PF17402.2 CDI76570.1 - 0.047 13.6 2.8 0.08 12.8 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5408) Serinc PF03348.15 CDI76572.1 - 2.9e-05 23.2 0.7 3.2e-05 23.1 0.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) TFIIA PF03153.13 CDI76572.1 - 0.00019 21.6 24.2 0.0002 21.5 24.2 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI76572.1 - 0.0015 19.2 14.9 0.0023 18.6 14.9 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_S49_N PF08496.10 CDI76572.1 - 0.0044 17.1 4.0 0.0057 16.7 4.0 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal PIEZO PF15917.5 CDI76572.1 - 0.0058 16.1 10.1 0.0073 15.8 10.1 1.2 1 0 0 1 1 1 1 Piezo CCDC53 PF10152.9 CDI76572.1 - 0.0082 16.6 5.0 0.01 16.2 5.0 1.3 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Suf PF05843.14 CDI76572.1 - 0.0088 16.1 7.2 0.0093 16.0 7.2 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Connexin PF00029.19 CDI76572.1 - 0.0096 15.7 1.1 0.011 15.4 1.1 1.2 1 0 0 1 1 1 1 Connexin Neur_chan_memb PF02932.16 CDI76572.1 - 0.0098 16.0 1.7 0.011 15.8 1.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region NEMP PF10225.9 CDI76572.1 - 0.011 15.4 3.5 0.014 15.0 3.5 1.1 1 0 0 1 1 1 0 NEMP family IgaA PF07095.11 CDI76572.1 - 0.015 13.3 2.4 0.015 13.3 2.4 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA SARAF PF06682.12 CDI76572.1 - 0.016 14.9 6.6 0.02 14.6 6.6 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF1980 PF09323.10 CDI76572.1 - 0.017 15.1 1.8 0.023 14.6 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) FHIPEP PF00771.20 CDI76572.1 - 0.019 13.5 2.9 0.024 13.1 2.9 1.1 1 0 0 1 1 1 0 FHIPEP family DDHD PF02862.17 CDI76572.1 - 0.022 14.9 3.0 0.025 14.8 3.0 1.2 1 0 0 1 1 1 0 DDHD domain Velvet PF11754.8 CDI76572.1 - 0.024 14.6 5.6 0.029 14.3 5.6 1.1 1 0 0 1 1 1 0 Velvet factor CPSF100_C PF13299.6 CDI76572.1 - 0.03 14.5 2.5 0.037 14.2 2.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SID-1_RNA_chan PF13965.6 CDI76572.1 - 0.037 12.5 0.2 0.042 12.3 0.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Calc_CGRP_IAPP PF00214.19 CDI76572.1 - 0.042 14.2 3.8 0.057 13.8 3.8 1.3 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family Presenilin PF01080.17 CDI76572.1 - 0.043 12.6 9.0 0.052 12.3 9.0 1.1 1 0 0 1 1 1 0 Presenilin FPN1 PF06963.12 CDI76572.1 - 0.044 12.4 2.2 0.057 12.0 2.2 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) PAT1 PF09770.9 CDI76572.1 - 0.048 12.0 15.8 0.052 11.8 15.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Prok-JAB PF14464.6 CDI76572.1 - 0.061 13.1 2.5 0.1 12.4 2.5 1.4 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain DUF4834 PF16118.5 CDI76572.1 - 0.065 14.2 11.5 0.15 13.1 11.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) CSG2 PF16965.5 CDI76572.1 - 0.069 12.1 0.4 0.081 11.9 0.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator HemX PF04375.14 CDI76572.1 - 0.095 12.0 23.8 0.11 11.7 23.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase V_ATPase_I PF01496.19 CDI76572.1 - 0.12 10.3 5.0 0.14 10.1 5.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peroxin-13_N PF04088.13 CDI76572.1 - 0.12 12.6 2.5 0.17 12.2 2.5 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region SpoIIP PF07454.11 CDI76572.1 - 0.13 11.7 5.8 0.15 11.5 5.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Jak1_Phl PF17887.1 CDI76572.1 - 0.16 12.0 8.3 0.22 11.5 8.3 1.2 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain XRN_N PF03159.18 CDI76572.1 - 0.18 11.2 6.0 0.21 11.0 6.0 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus CLN3 PF02487.17 CDI76572.1 - 0.2 10.7 2.9 0.24 10.4 2.9 1.1 1 0 0 1 1 1 0 CLN3 protein Spore_coat_CotO PF14153.6 CDI76572.1 - 0.26 11.2 12.2 0.32 10.9 12.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO FliP PF00813.20 CDI76572.1 - 0.26 11.1 2.5 0.31 10.9 2.5 1.1 1 0 0 1 1 1 0 FliP family DUF4446 PF14584.6 CDI76572.1 - 0.27 11.2 1.4 0.45 10.5 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Folliculin PF11704.8 CDI76572.1 - 0.31 10.9 7.5 0.47 10.3 7.5 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Baculo_PP31 PF05311.11 CDI76572.1 - 0.32 10.4 6.6 0.4 10.1 6.6 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) EOS1 PF12326.8 CDI76572.1 - 0.34 10.8 1.7 0.43 10.5 1.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF2232 PF09991.9 CDI76572.1 - 0.41 9.8 3.0 0.57 9.3 3.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) OATP PF03137.20 CDI76572.1 - 0.41 8.9 1.6 0.54 8.5 1.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4569 PF15133.6 CDI76572.1 - 0.47 10.1 8.9 0.56 9.9 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Gastrin PF00918.17 CDI76572.1 - 0.47 11.4 7.9 0.9 10.5 7.9 1.5 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Exonuc_VII_L PF02601.15 CDI76572.1 - 0.49 9.9 13.4 0.63 9.6 13.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit eIF-3_zeta PF05091.12 CDI76572.1 - 0.55 9.1 15.2 0.65 8.9 15.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CBP_BcsG PF11658.8 CDI76572.1 - 0.59 8.5 8.2 0.75 8.1 8.2 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Ctr PF04145.15 CDI76572.1 - 0.82 10.3 9.9 0.36 11.4 7.5 1.5 1 1 0 2 2 1 0 Ctr copper transporter family AIF_C PF14721.6 CDI76572.1 - 0.91 9.9 5.9 1.4 9.3 5.9 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TERB2 PF15101.6 CDI76572.1 - 1.3 9.0 14.5 1.6 8.7 14.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Roughex PF06020.11 CDI76572.1 - 1.5 7.8 10.4 2 7.4 10.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein BAF1_ABF1 PF04684.13 CDI76572.1 - 1.8 7.5 12.1 2.4 7.1 12.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor OAD_gamma PF04277.13 CDI76572.1 - 2.2 9.0 11.8 2.1 9.0 8.1 2.4 2 1 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain FAM199X PF15814.5 CDI76572.1 - 2.9 6.9 5.1 3.3 6.7 5.1 1.3 1 0 0 1 1 1 0 Protein family FAM199X BRF1 PF07741.13 CDI76572.1 - 3.2 8.2 10.8 4.8 7.6 10.8 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF2722 PF10846.8 CDI76572.1 - 3.4 6.5 25.9 4.7 6.0 25.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Herpes_UL32 PF06070.11 CDI76572.1 - 3.6 5.2 15.8 4.7 4.8 15.8 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 RR_TM4-6 PF06459.12 CDI76572.1 - 3.9 7.2 10.2 5 6.9 10.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 JSRP PF15312.6 CDI76572.1 - 7.6 6.5 6.4 29 4.7 6.4 2.2 1 1 0 1 1 1 0 Junctional sarcoplasmic reticulum protein DUF3450 PF11932.8 CDI76572.1 - 8.8 5.5 26.7 12 5.1 26.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) EIIBC-GUT_N PF03612.14 CDI76572.1 - 9.5 5.9 9.1 13 5.4 9.1 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PAP2_C PF14360.6 CDI76573.1 - 4.5e-07 30.3 2.7 9.4e-07 29.3 2.7 1.5 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF2722 PF10846.8 CDI76575.1 - 0.00017 20.7 1.8 0.00027 20.0 1.8 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) Secretin_N_2 PF07655.13 CDI76575.1 - 0.45 11.1 12.1 3.8 8.1 9.1 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain DUF4834 PF16118.5 CDI76575.1 - 0.51 11.3 4.4 0.58 11.1 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Rrn6 PF10214.9 CDI76575.1 - 6.1 5.2 13.1 1.7 7.0 3.4 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor GTP_EFTU_D3 PF03143.17 CDI76579.1 - 1.3e-25 89.9 0.0 1.8e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDI76579.1 - 0.038 14.4 0.1 0.08 13.3 0.1 1.5 1 0 0 1 1 1 0 Elongation factor Tu domain 2 HAUS-augmin3 PF14932.6 CDI76580.1 - 0.00028 20.6 8.0 0.00037 20.2 8.0 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 SUIM_assoc PF16619.5 CDI76580.1 - 0.22 11.6 5.2 0.63 10.1 5.2 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SPG4 PF17325.2 CDI76580.1 - 0.5 11.5 8.6 0.087 13.9 4.7 1.7 2 0 0 2 2 2 0 Stationary phase protein 4 Integrase_H2C2 PF17921.1 CDI76581.1 - 6.7e-13 48.5 0.1 1.3e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 CDI76581.1 - 9.9e-13 48.3 0.3 1.8e-12 47.5 0.3 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDI76581.1 - 4.8e-05 23.5 0.2 0.00032 20.9 0.0 2.2 3 0 0 3 3 3 1 Integrase core domain RT_RNaseH_2 PF17919.1 CDI76581.1 - 0.00012 22.0 0.0 0.00024 21.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI76582.1 - 2.2e-06 27.3 0.0 3.4e-06 26.7 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 CDI76583.1 - 7.2e-29 99.4 0.1 5.1e-15 55.0 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI76583.1 - 4e-06 26.9 0.0 0.031 14.4 0.0 3.1 2 2 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 CDI76583.1 - 0.018 14.7 0.1 0.46 10.2 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Chorein_N PF12624.7 CDI76585.1 - 1.3e-18 67.2 4.5 3.6e-18 65.8 0.0 2.7 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 CDI76585.1 - 1.4e-10 41.4 0.0 5.1e-09 36.3 0.0 2.5 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal SUIM_assoc PF16619.5 CDI76585.1 - 2.9 8.0 23.3 0.12 12.4 7.5 3.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Kinesin PF00225.23 CDI76586.1 - 2.7e-65 220.5 2.1 5.4e-63 212.9 0.1 3.4 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CDI76586.1 - 0.00024 21.1 1.8 0.0043 17.0 0.1 2.9 2 1 0 2 2 2 1 Microtubule binding RA PF00788.23 CDI76586.1 - 0.021 15.5 0.7 0.059 14.0 0.7 1.8 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain BURP PF03181.15 CDI76587.1 - 0.62 9.6 3.6 0.71 9.4 3.6 1.1 1 0 0 1 1 1 0 BURP domain PPP4R2 PF09184.11 CDI76587.1 - 2.5 7.6 12.5 2.7 7.5 12.5 1.1 1 0 0 1 1 1 0 PPP4R2 Apt1 PF10351.9 CDI76587.1 - 7.9 5.2 21.2 11 4.7 21.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4794 PF16042.5 CDI76588.1 - 0.04 14.9 2.0 0.2 12.7 2.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4794) zn-ribbon_14 PF16503.5 CDI76589.1 - 3.9e-08 32.7 3.9 3.9e-08 32.7 3.9 3.4 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 CDI76589.1 - 1.5e-07 31.4 0.0 8.5e-07 28.9 0.0 2.1 1 1 0 1 1 1 1 PP-loop family Pex14_N PF04695.13 CDI76589.1 - 9.3 6.9 20.4 0.43 11.2 0.8 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C2H2_4 PF13894.6 CDI76591.1 - 9.6e-06 26.0 4.3 0.044 14.6 0.6 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger DDHD PF02862.17 CDI76591.1 - 0.0005 20.3 4.0 0.00062 20.0 4.0 1.1 1 0 0 1 1 1 1 DDHD domain zf-C2H2_jaz PF12171.8 CDI76591.1 - 0.0017 18.6 0.4 0.0017 18.6 0.4 2.1 2 0 0 2 2 1 1 Zinc-finger double-stranded RNA-binding Ctr PF04145.15 CDI76591.1 - 0.0039 17.8 3.4 0.0053 17.4 3.4 1.2 1 0 0 1 1 1 1 Ctr copper transporter family CAF1 PF04857.20 CDI76591.1 - 0.0044 16.2 1.1 0.005 16.0 1.1 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease CDC45 PF02724.14 CDI76591.1 - 0.0044 15.4 9.3 0.0054 15.1 9.3 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF5308 PF17233.2 CDI76591.1 - 0.0072 16.6 2.6 0.0096 16.2 2.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5308) DUF913 PF06025.12 CDI76591.1 - 0.0087 15.1 6.3 0.012 14.7 6.3 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Pex14_N PF04695.13 CDI76591.1 - 0.0098 16.6 15.3 0.0098 16.6 15.3 1.8 2 1 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.8 CDI76591.1 - 0.014 14.2 12.8 0.02 13.7 12.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MecA PF05389.12 CDI76591.1 - 0.015 14.9 8.0 0.025 14.2 8.0 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF2126 PF09899.9 CDI76591.1 - 0.017 13.3 6.0 0.02 13.0 6.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) EPL1 PF10513.9 CDI76591.1 - 0.017 15.5 10.1 0.025 15.0 10.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Suf PF05843.14 CDI76591.1 - 0.022 14.8 10.6 0.026 14.5 10.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TMEM51 PF15345.6 CDI76591.1 - 0.022 14.6 9.3 0.033 14.0 9.3 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 eIF-3_zeta PF05091.12 CDI76591.1 - 0.022 13.8 15.6 0.027 13.5 15.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_11 PF13086.6 CDI76591.1 - 0.023 14.5 11.5 0.033 14.0 11.5 1.2 1 0 0 1 1 1 0 AAA domain SLC12 PF03522.15 CDI76591.1 - 0.023 13.7 11.4 0.028 13.4 11.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 LicD PF04991.13 CDI76591.1 - 0.024 14.8 4.9 0.03 14.4 4.9 1.1 1 0 0 1 1 1 0 LicD family CPSF100_C PF13299.6 CDI76591.1 - 0.027 14.6 9.6 0.04 14.1 9.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CCDC53 PF10152.9 CDI76591.1 - 0.031 14.7 11.4 0.06 13.8 11.4 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DAG_kinase_N PF14513.6 CDI76591.1 - 0.033 14.4 13.2 0.049 13.8 13.2 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus NPR3 PF03666.13 CDI76591.1 - 0.035 12.9 14.0 0.047 12.5 14.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2 PF00096.26 CDI76591.1 - 0.036 14.5 4.3 1.2 9.8 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Band_3_cyto PF07565.13 CDI76591.1 - 0.047 13.5 7.5 0.059 13.2 7.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI76591.1 - 0.055 13.5 9.1 0.073 13.1 9.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SET PF00856.28 CDI76591.1 - 0.055 13.8 0.6 0.08 13.3 0.6 1.3 1 0 0 1 1 1 0 SET domain RR_TM4-6 PF06459.12 CDI76591.1 - 0.058 13.2 20.1 0.082 12.7 20.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 CDI76591.1 - 0.06 10.5 7.9 0.067 10.3 7.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4746 PF15928.5 CDI76591.1 - 0.06 12.8 10.5 0.079 12.4 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RP-C_C PF11800.8 CDI76591.1 - 0.068 13.3 10.7 0.091 12.8 10.7 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region ALMT PF11744.8 CDI76591.1 - 0.069 12.0 10.2 0.08 11.8 10.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2722 PF10846.8 CDI76591.1 - 0.076 11.9 20.1 0.11 11.4 20.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Afi1 PF07792.12 CDI76591.1 - 0.081 13.4 10.7 0.12 12.8 10.7 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TERB2 PF15101.6 CDI76591.1 - 0.082 13.0 18.0 0.13 12.3 18.0 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 LAP1C PF05609.12 CDI76591.1 - 0.11 11.6 13.0 0.14 11.3 13.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) V_ATPase_I PF01496.19 CDI76591.1 - 0.17 9.7 17.6 0.23 9.3 17.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 CDI76591.1 - 0.19 10.9 6.8 0.3 10.2 6.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter LIM_bind PF01803.16 CDI76591.1 - 0.19 11.2 9.3 0.32 10.5 9.3 1.3 1 0 0 1 1 1 0 LIM-domain binding protein tRNA-synt_2c PF01411.19 CDI76591.1 - 0.2 10.1 7.6 0.26 9.8 7.6 1.1 1 0 0 1 1 1 0 tRNA synthetases class II (A) SpoVR PF04293.13 CDI76591.1 - 0.24 10.1 11.3 0.32 9.6 11.3 1.1 1 0 0 1 1 1 0 SpoVR like protein SAPS PF04499.15 CDI76591.1 - 0.24 10.2 9.4 0.3 9.8 9.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MAJIN PF15077.6 CDI76591.1 - 0.24 11.2 10.1 0.37 10.6 10.1 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein AAA_23 PF13476.6 CDI76591.1 - 0.31 11.5 21.9 0.41 11.1 21.9 1.2 1 0 0 1 1 1 0 AAA domain FancD2 PF14631.6 CDI76591.1 - 0.33 8.3 10.3 0.4 8.0 10.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease SID-1_RNA_chan PF13965.6 CDI76591.1 - 0.35 9.2 2.9 0.39 9.1 2.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 XRN_M PF17846.1 CDI76591.1 - 0.36 9.7 13.2 0.48 9.3 13.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Atg14 PF10186.9 CDI76591.1 - 0.36 9.9 16.2 0.47 9.5 16.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EOS1 PF12326.8 CDI76591.1 - 0.37 10.7 5.1 0.59 10.0 5.1 1.4 1 0 0 1 1 1 0 N-glycosylation protein NARP1 PF12569.8 CDI76591.1 - 0.38 9.6 23.2 0.52 9.2 23.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2052 PF09747.9 CDI76591.1 - 0.38 10.8 18.0 0.52 10.4 18.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) BORG_CEP PF14957.6 CDI76591.1 - 0.38 11.9 7.6 0.76 11.0 7.6 1.5 1 0 0 1 1 1 0 Cdc42 effector PAT1 PF09770.9 CDI76591.1 - 0.41 8.9 19.6 0.49 8.6 19.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2828 PF11443.8 CDI76591.1 - 0.46 8.5 16.7 0.61 8.1 16.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 CDI76591.1 - 0.46 10.2 13.6 0.66 9.7 13.6 1.2 1 0 0 1 1 1 0 Connexin PA26 PF04636.13 CDI76591.1 - 0.51 9.2 9.5 0.65 8.9 9.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) ABC2_membrane_2 PF12679.7 CDI76591.1 - 0.54 9.5 1.4 0.71 9.1 1.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein PPL5 PF18168.1 CDI76591.1 - 0.69 9.2 12.3 0.97 8.7 12.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Fmp27 PF10344.9 CDI76591.1 - 0.86 7.6 12.4 1.1 7.2 12.4 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Kei1 PF08552.11 CDI76591.1 - 0.87 9.4 9.2 1.3 8.9 9.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CSG2 PF16965.5 CDI76591.1 - 0.89 8.4 9.0 1.2 8.0 9.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Coilin_N PF15862.5 CDI76591.1 - 0.93 9.3 22.2 1.9 8.3 22.2 1.5 1 0 0 1 1 1 0 Coilin N-terminus Presenilin PF01080.17 CDI76591.1 - 0.95 8.2 19.8 1.5 7.5 19.8 1.2 1 0 0 1 1 1 0 Presenilin DUF2151 PF10221.9 CDI76591.1 - 1.1 7.8 11.9 1.4 7.5 11.9 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator MMM1 PF10296.9 CDI76591.1 - 1.1 8.2 10.7 1.6 7.7 10.7 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF2370 PF10176.9 CDI76591.1 - 1.2 8.8 5.8 1.6 8.3 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) FAM60A PF15396.6 CDI76591.1 - 1.2 9.1 16.0 1.8 8.5 16.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Dicty_REP PF05086.12 CDI76591.1 - 1.3 6.9 8.1 1.5 6.7 8.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4175 PF13779.6 CDI76591.1 - 1.5 6.6 27.2 2 6.2 27.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CRT10 PF08728.10 CDI76591.1 - 1.6 6.8 7.0 1.9 6.5 7.0 1.0 1 0 0 1 1 1 0 CRT10 SpoIIP PF07454.11 CDI76591.1 - 1.8 8.0 21.3 2.4 7.6 21.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF3_subunit PF08597.10 CDI76591.1 - 1.8 8.4 25.6 2.6 7.9 25.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Cellulose_synt PF03552.14 CDI76591.1 - 2 6.8 6.2 2.6 6.4 6.2 1.1 1 0 0 1 1 1 0 Cellulose synthase Hydin_ADK PF17213.3 CDI76591.1 - 2.1 8.6 9.6 3.4 7.9 9.6 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain HSP70 PF00012.20 CDI76591.1 - 2.3 6.3 14.3 3 5.9 14.3 1.0 1 0 0 1 1 1 0 Hsp70 protein TAF4 PF05236.14 CDI76591.1 - 2.5 7.8 22.9 3.5 7.3 22.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family LMBR1 PF04791.16 CDI76591.1 - 2.7 6.8 11.3 3.4 6.5 11.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein MMU163 PF17119.5 CDI76591.1 - 2.8 7.0 9.0 3.9 6.6 9.0 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis MMR1 PF08505.10 CDI76591.1 - 3 8.1 17.7 4.7 7.4 17.7 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DcuA_DcuB PF03605.14 CDI76591.1 - 3 6.6 4.2 4.3 6.1 4.2 1.2 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF3492 PF11997.8 CDI76591.1 - 3.1 7.5 6.6 4.5 6.9 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Serinc PF03348.15 CDI76591.1 - 3.4 6.5 9.7 4.8 6.0 9.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Rrn6 PF10214.9 CDI76591.1 - 3.9 5.9 16.0 5 5.5 16.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor UPF0560 PF10577.9 CDI76591.1 - 4.3 5.7 16.8 5.9 5.3 16.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Spore_coat_CotO PF14153.6 CDI76591.1 - 4.3 7.2 26.0 6.7 6.6 26.0 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF4834 PF16118.5 CDI76591.1 - 4.4 8.3 16.7 9 7.3 16.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Hid1 PF12722.7 CDI76591.1 - 4.5 5.3 13.4 5.7 4.9 13.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gti1_Pac2 PF09729.9 CDI76591.1 - 4.8 7.2 15.7 7.1 6.7 15.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Het-C PF07217.11 CDI76591.1 - 4.8 5.6 10.9 6.3 5.2 10.9 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Membralin PF09746.9 CDI76591.1 - 5.7 5.9 10.9 7.6 5.5 10.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein DDRGK PF09756.9 CDI76591.1 - 5.9 6.4 35.8 8 6.0 35.8 1.1 1 0 0 1 1 1 0 DDRGK domain Folliculin PF11704.8 CDI76591.1 - 6 6.7 12.2 10 5.9 12.2 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport OATP PF03137.20 CDI76591.1 - 6.4 4.9 8.6 8.8 4.5 8.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4775 PF16001.5 CDI76591.1 - 6.8 6.0 21.7 11 5.3 21.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Nucleoside_tran PF01733.18 CDI76591.1 - 6.9 6.0 5.8 9.6 5.5 5.8 1.1 1 0 0 1 1 1 0 Nucleoside transporter DUF4407 PF14362.6 CDI76591.1 - 7.6 5.8 17.1 10 5.3 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HCO3_cotransp PF00955.21 CDI76591.1 - 8.1 5.1 5.1 11 4.7 5.1 1.1 1 0 0 1 1 1 0 HCO3- transporter family Ureide_permease PF07168.11 CDI76591.1 - 8.3 5.1 9.1 12 4.6 9.1 1.2 1 0 0 1 1 1 0 Ureide permease PIP5K PF01504.18 CDI76591.1 - 9.3 5.4 13.0 14 4.8 13.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase FemAB PF02388.16 CDI76591.1 - 9.8 4.9 19.7 5.5 5.8 18.0 1.3 2 0 0 2 2 1 0 FemAB family Ribosomal_60s PF00428.19 CDI76593.1 - 0.0098 16.5 10.6 0.14 12.8 0.2 2.7 2 0 0 2 2 2 2 60s Acidic ribosomal protein Arabinose_trans PF04602.12 CDI76593.1 - 0.026 13.4 4.9 0.044 12.6 1.5 2.0 2 0 0 2 2 2 0 Mycobacterial cell wall arabinan synthesis protein Spt20 PF12090.8 CDI76593.1 - 0.63 9.6 17.5 3.1 7.3 0.1 2.2 2 0 0 2 2 2 0 Spt20 family SNF2_N PF00176.23 CDI76594.1 - 0.00018 20.4 0.6 0.0056 15.4 0.0 2.8 3 0 0 3 3 3 1 SNF2 family N-terminal domain DUF4667 PF15700.5 CDI76594.1 - 0.0021 18.2 1.8 0.0021 18.2 1.8 4.9 3 1 0 4 4 4 1 Domain of unknown function (DUF4667) SPX PF03105.19 CDI76594.1 - 0.22 11.4 29.2 0.42 10.5 6.1 3.3 3 0 0 3 3 3 0 SPX domain SKIP_SNW PF02731.15 CDI76594.1 - 0.94 9.1 6.5 1.7 8.3 6.5 1.3 1 0 0 1 1 1 0 SKIP/SNW domain Roughex PF06020.11 CDI76594.1 - 5 6.1 7.0 11 5.1 7.0 1.5 1 0 0 1 1 1 0 Drosophila roughex protein DUF2722 PF10846.8 CDI76595.1 - 0.00022 20.3 1.6 0.00022 20.3 1.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) HHH PF00633.23 CDI76595.1 - 0.074 13.0 0.1 2 8.5 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF4834 PF16118.5 CDI76595.1 - 6.8 7.7 5.5 1.3 10.0 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF3292 PF11696.8 CDI76595.1 - 9.8 4.4 12.5 0.27 9.6 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) CemA PF03040.14 CDI76596.1 - 0.29 11.0 1.2 0.54 10.2 1.2 1.3 1 0 0 1 1 1 0 CemA family Gly_transf_sug PF04488.15 CDI76598.1 - 2.7e-07 31.1 0.0 8.1e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TFIIA PF03153.13 CDI76598.1 - 0.0027 17.8 13.7 0.0027 17.8 13.7 4.8 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76598.1 - 0.0055 16.3 6.5 0.0055 16.3 6.5 5.3 4 1 0 4 4 4 1 Spt20 family Connexin PF00029.19 CDI76598.1 - 7.6 6.2 9.0 2.6 7.7 0.0 3.4 3 0 0 3 3 3 0 Connexin Spt20 PF12090.8 CDI76600.1 - 1.6e-05 24.7 47.4 0.00037 20.2 19.2 2.1 2 0 0 2 2 2 2 Spt20 family TFIIA PF03153.13 CDI76600.1 - 3.7e-05 23.9 42.2 0.012 15.6 22.8 2.0 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit HNOBA PF07701.14 CDI76600.1 - 0.00025 20.6 1.7 0.026 14.0 0.0 2.2 2 0 0 2 2 2 1 Heme NO binding associated BCDHK_Adom3 PF10436.9 CDI76600.1 - 0.00037 20.4 0.0 0.00037 20.4 0.0 2.4 3 0 0 3 3 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF2722 PF10846.8 CDI76600.1 - 0.0021 17.1 7.7 0.0021 17.1 7.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Miff PF05644.11 CDI76600.1 - 0.0041 16.8 7.2 0.0041 16.8 7.2 2.1 2 0 0 2 2 2 1 Mitochondrial and peroxisomal fission factor Mff CNDH2_C PF16858.5 CDI76600.1 - 0.0059 16.5 13.1 0.049 13.5 5.9 2.0 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term MMR1 PF08505.10 CDI76600.1 - 0.018 15.4 9.7 0.018 15.4 9.7 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein MecA PF05389.12 CDI76600.1 - 0.026 14.2 9.4 0.3 10.7 3.2 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) FAM176 PF14851.6 CDI76600.1 - 0.075 12.7 14.8 1.9 8.1 0.3 2.2 2 0 0 2 2 2 0 FAM176 family MMM1 PF10296.9 CDI76600.1 - 0.085 11.9 0.1 0.085 11.9 0.1 2.1 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 Pex14_N PF04695.13 CDI76600.1 - 0.091 13.4 30.0 0.3 11.7 14.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI76600.1 - 0.12 12.8 17.9 1 9.8 1.3 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like PTPRCAP PF15713.5 CDI76600.1 - 0.15 12.4 18.2 0.49 10.7 9.3 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated TMEM51 PF15345.6 CDI76600.1 - 0.16 11.8 24.7 0.12 12.1 4.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 FAM220 PF15487.6 CDI76600.1 - 0.18 11.4 11.9 0.04 13.6 6.0 2.0 2 0 0 2 2 2 0 FAM220 family Neur_chan_memb PF02932.16 CDI76600.1 - 0.2 11.7 12.9 0.58 10.2 5.4 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 CDI76600.1 - 0.23 10.9 17.4 0.29 10.5 7.3 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 CDI76600.1 - 0.23 11.5 27.1 1.5 8.9 13.1 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI76600.1 - 0.28 10.1 22.8 0.82 8.6 10.5 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAT1 PF06391.13 CDI76600.1 - 0.33 10.8 23.4 1.4 8.7 10.2 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 BORG_CEP PF14957.6 CDI76600.1 - 0.34 12.1 11.5 3.5 8.8 6.3 2.3 2 0 0 2 2 2 0 Cdc42 effector Suf PF05843.14 CDI76600.1 - 0.35 10.8 22.1 1.3 9.0 4.9 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Apc15p PF05841.11 CDI76600.1 - 0.38 11.6 26.6 1.4 9.7 13.6 2.3 2 0 0 2 2 2 0 Apc15p protein DUF4770 PF15994.5 CDI76600.1 - 0.38 11.0 19.5 0.96 9.7 7.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Tim54 PF11711.8 CDI76600.1 - 0.43 9.3 14.4 0.55 9.0 5.9 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 RLL PF10036.9 CDI76600.1 - 0.55 10.0 22.9 1.8 8.4 4.5 2.1 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein DUF1266 PF06889.11 CDI76600.1 - 0.55 10.3 10.4 1.4 9.0 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) AF-4 PF05110.13 CDI76600.1 - 0.57 8.2 23.0 0.53 8.3 13.1 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF719 PF05334.13 CDI76600.1 - 0.62 10.2 12.5 5.2 7.2 5.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) CPSF100_C PF13299.6 CDI76600.1 - 0.66 10.1 16.4 2.2 8.4 9.4 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM91_C PF14648.6 CDI76600.1 - 0.69 8.7 7.0 0.54 9.0 1.1 2.0 2 0 0 2 2 2 0 FAM91 C-terminus RPA43_OB PF17875.1 CDI76600.1 - 0.72 10.5 12.1 1.6 9.3 0.1 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF4471 PF14740.6 CDI76600.1 - 0.83 8.8 11.1 3 7.0 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF913 PF06025.12 CDI76600.1 - 0.85 8.5 10.4 0.85 8.5 6.2 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF2235 PF09994.9 CDI76600.1 - 0.9 8.8 6.6 8.9 5.6 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) eIF_4EBP PF05456.11 CDI76600.1 - 1 9.3 15.0 2.1 8.3 2.0 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) SLC12 PF03522.15 CDI76600.1 - 1.4 7.9 16.6 1.1 8.2 8.0 2.0 2 0 0 2 2 2 0 Solute carrier family 12 DUF4820 PF16091.5 CDI76600.1 - 1.5 8.1 15.5 0.94 8.8 5.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF702 PF05142.12 CDI76600.1 - 1.7 9.1 23.2 4 7.9 3.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Peptidase_S49_N PF08496.10 CDI76600.1 - 1.7 8.7 16.3 4.1 7.5 3.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Pannexin_like PF12534.8 CDI76600.1 - 1.7 7.6 14.3 1.6 7.8 3.5 2.2 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 PNISR PF15996.5 CDI76600.1 - 1.8 8.8 24.8 0.039 14.2 7.4 2.3 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF5352 PF17303.2 CDI76600.1 - 1.9 8.3 9.6 0.7 9.7 2.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5352) Band_3_cyto PF07565.13 CDI76600.1 - 1.9 8.2 16.6 3.4 7.4 7.3 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM60A PF15396.6 CDI76600.1 - 2.1 8.3 14.3 5.5 6.9 5.6 2.2 2 0 0 2 2 2 0 Protein Family FAM60A MPM1 PF17234.2 CDI76600.1 - 3 8.1 21.9 2.7 8.2 2.9 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 CTNNB1_binding PF08347.11 CDI76600.1 - 3.4 7.8 14.3 8.8 6.5 6.1 2.2 2 0 0 2 2 2 0 N-terminal CTNNB1 binding Connexin PF00029.19 CDI76600.1 - 3.5 7.3 13.4 11 5.7 7.2 2.1 2 0 0 2 2 2 0 Connexin BRF1 PF07741.13 CDI76600.1 - 3.5 8.0 18.2 5.4 7.4 1.4 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain UPF0560 PF10577.9 CDI76600.1 - 3.5 6.0 29.0 1.1 7.6 5.6 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 CDC45 PF02724.14 CDI76600.1 - 3.8 5.7 14.9 4 5.6 7.7 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF3807 PF12720.7 CDI76600.1 - 4.1 7.6 28.5 0.78 10.0 13.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF5327 PF17261.2 CDI76600.1 - 4.2 8.2 25.6 2.3 9.0 9.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5327) DUF1764 PF08576.10 CDI76600.1 - 4.3 8.3 16.2 5.5 8.0 6.4 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Hydin_ADK PF17213.3 CDI76600.1 - 4.4 7.5 15.3 6.5 7.0 6.3 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Afi1 PF07792.12 CDI76600.1 - 4.5 7.8 18.1 0.96 9.9 6.9 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ATAD4 PF15321.6 CDI76600.1 - 5.1 8.5 13.3 18 6.8 0.5 2.4 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 DUF2052 PF09747.9 CDI76600.1 - 5.3 7.1 22.4 0.58 10.3 9.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CLN3 PF02487.17 CDI76600.1 - 5.5 5.9 13.8 6.6 5.7 6.5 2.1 2 0 0 2 2 2 0 CLN3 protein Pet20 PF08692.10 CDI76600.1 - 6.2 7.6 9.6 6 7.6 2.9 2.2 2 0 0 2 2 2 0 Mitochondrial protein Pet20 PH_4 PF15404.6 CDI76600.1 - 6.7 6.5 13.4 3.1 7.6 0.5 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Ctr PF04145.15 CDI76600.1 - 6.9 7.3 11.4 21 5.7 5.2 2.2 2 0 0 2 2 2 0 Ctr copper transporter family RIC3 PF15361.6 CDI76600.1 - 7.5 6.9 10.5 14 6.1 4.0 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 PDDEXK_6 PF04720.12 CDI76600.1 - 7.6 6.4 18.5 2 8.3 10.6 2.1 2 0 0 2 2 2 0 PDDEXK-like family of unknown function MDM10 PF12519.8 CDI76600.1 - 7.7 5.3 12.5 14 4.4 7.1 2.0 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 ABC2_membrane_2 PF12679.7 CDI76600.1 - 8.1 5.6 8.2 2.1 7.6 1.3 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF966 PF06136.13 CDI76600.1 - 8.2 6.0 18.0 3.6 7.2 10.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF966) DUF4746 PF15928.5 CDI76600.1 - 8.4 5.7 13.1 0.63 9.4 3.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Slu7 PF11708.8 CDI76600.1 - 8.7 6.0 21.1 5.3 6.7 1.6 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor Folate_carrier PF01770.18 CDI76600.1 - 9.8 4.8 16.2 1.3 7.7 3.0 2.1 2 0 0 2 2 2 0 Reduced folate carrier CTU2 PF10288.9 CDI76600.1 - 9.9 6.4 20.6 11 6.3 6.2 2.3 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 HATPase_c PF02518.26 CDI76601.1 - 8.3e-07 29.5 0.0 0.00082 19.9 0.0 3.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TFIIA PF03153.13 CDI76601.1 - 0.024 14.7 19.5 0.031 14.3 19.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI76601.1 - 0.047 12.5 4.5 0.055 12.2 4.5 1.1 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI76601.1 - 0.082 12.5 21.4 0.13 11.9 21.4 1.3 1 0 0 1 1 1 0 Spt20 family AIF_C PF14721.6 CDI76601.1 - 0.14 12.5 3.2 0.29 11.5 3.2 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RPA43_OB PF17875.1 CDI76601.1 - 0.16 12.6 4.2 0.27 11.9 4.2 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I G0-G1_switch_2 PF15103.6 CDI76601.1 - 0.18 12.3 6.6 37 4.8 0.0 2.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 DHHW PF14286.6 CDI76601.1 - 0.23 10.7 1.7 0.34 10.2 1.7 1.2 1 0 0 1 1 1 0 DHHW protein Ureide_permease PF07168.11 CDI76601.1 - 0.29 9.8 1.1 0.45 9.2 1.1 1.2 1 0 0 1 1 1 0 Ureide permease eIF-3_zeta PF05091.12 CDI76601.1 - 0.54 9.2 8.6 0.76 8.7 8.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) UPF0560 PF10577.9 CDI76601.1 - 0.61 8.5 11.3 0.9 8.0 11.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SpoIIP PF07454.11 CDI76601.1 - 0.62 9.5 7.9 0.9 8.9 7.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI76601.1 - 0.8 9.9 6.8 1.4 9.1 6.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 CDI76601.1 - 1.4 8.6 4.3 2.5 7.8 4.3 1.3 1 0 0 1 1 1 0 Connexin TERB2 PF15101.6 CDI76601.1 - 2.3 8.2 10.6 4.1 7.4 10.6 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2722 PF10846.8 CDI76601.1 - 2.8 6.8 22.3 4.6 6.1 22.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) EIIBC-GUT_N PF03612.14 CDI76601.1 - 2.9 7.6 6.3 5.1 6.8 6.3 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MDM31_MDM32 PF08118.11 CDI76601.1 - 3.3 6.3 6.9 4.6 5.8 6.9 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FAM176 PF14851.6 CDI76601.1 - 4.7 6.9 7.7 8.5 6.0 7.7 1.3 1 0 0 1 1 1 0 FAM176 family Roughex PF06020.11 CDI76601.1 - 4.9 6.1 8.7 8.1 5.4 8.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein V_ATPase_I PF01496.19 CDI76601.1 - 5.6 4.8 7.7 8.1 4.2 7.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Activator_LAG-3 PF11498.8 CDI76601.1 - 5.7 5.8 26.5 9.9 5.0 26.5 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3464 PF11947.8 CDI76601.1 - 6.8 6.4 10.2 12 5.6 10.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DivIC PF04977.15 CDI76601.1 - 9.8 6.0 13.0 18 5.2 13.0 1.3 1 0 0 1 1 1 0 Septum formation initiator Btz PF09405.10 CDI76603.1 - 1.8e-10 41.2 11.7 1.8e-10 41.2 11.7 2.2 2 1 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding DUF4407 PF14362.6 CDI76603.1 - 0.02 14.2 3.6 0.027 13.8 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LAP1C PF05609.12 CDI76603.1 - 9.6 5.2 8.7 13 4.8 8.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) OCRE PF17780.1 CDI76604.1 - 0.00012 22.0 0.6 0.00025 21.0 0.6 1.5 1 0 0 1 1 1 1 OCRE domain zinc_ribbon_2 PF13240.6 CDI76604.1 - 0.24 11.1 2.5 1.1 9.1 2.5 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Vps36-NZF-N PF16988.5 CDI76604.1 - 1.8 8.0 10.6 0.063 12.7 2.1 3.1 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF2722 PF10846.8 CDI76605.1 - 2.3e-06 26.8 18.2 0.00049 19.2 1.9 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) HNOBA PF07701.14 CDI76605.1 - 0.044 13.2 3.5 4.4 6.7 0.1 2.6 2 0 0 2 2 2 0 Heme NO binding associated EOS1 PF12326.8 CDI76605.1 - 0.16 11.9 3.2 5.5 6.9 0.4 2.7 2 0 0 2 2 2 0 N-glycosylation protein DNApol_Exo PF18136.1 CDI76605.1 - 4.8 6.2 12.1 1.3 8.1 0.8 2.5 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain RNA_pol_Rbc25 PF08292.12 CDI76605.1 - 4.9 7.4 11.6 2.8 8.2 0.2 3.1 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 GMP_synt_C PF00958.22 CDI76609.1 - 7e-43 144.6 0.0 1e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 GMP synthase C terminal domain RNA_pol_L PF01193.24 CDI76610.1 - 2.8e-10 39.5 0.0 3.5e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 CDI76610.1 - 6e-07 29.8 0.0 9.4e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain DUF4533 PF15047.6 CDI76611.1 - 0.13 11.9 5.1 0.072 12.6 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4533) PhoU PF01895.19 CDI76611.1 - 0.53 10.8 3.9 29 5.2 0.1 3.7 3 0 0 3 3 3 0 PhoU domain Halogen_Hydrol PF10112.9 CDI76611.1 - 1.9 8.5 5.2 21 5.1 0.3 3.4 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein RskA PF10099.9 CDI76613.1 - 0.0013 19.0 5.9 0.0013 19.0 5.9 4.3 1 1 2 3 3 3 1 Anti-sigma-K factor rskA CLN3 PF02487.17 CDI76613.1 - 0.37 9.8 6.7 0.2 10.7 3.0 2.2 3 0 0 3 3 3 0 CLN3 protein PIP5K PF01504.18 CDI76613.1 - 6.5 5.9 7.0 0.48 9.6 2.0 1.6 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Transformer PF06495.11 CDI76619.1 - 0.011 15.9 3.5 0.022 14.9 3.5 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein Suf PF05843.14 CDI76619.1 - 0.028 14.4 8.4 0.055 13.4 8.4 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4667 PF15700.5 CDI76619.1 - 0.15 12.1 9.8 0.34 11.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) DUF1645 PF07816.11 CDI76619.1 - 2.4 8.7 19.7 0.052 14.1 1.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1645) Neur_chan_memb PF02932.16 CDI76619.1 - 3.3 7.7 5.8 7.8 6.5 5.8 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region JUPITER PF17054.5 CDI76619.1 - 3.4 7.1 6.5 8.4 5.7 6.5 1.7 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Sec62 PF03839.16 CDI76621.1 - 0.0021 17.6 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 EXS PF03124.14 CDI76623.1 - 1.1e-29 103.9 14.2 1.4e-28 100.2 14.2 2.1 1 1 0 1 1 1 1 EXS family SPX PF03105.19 CDI76623.1 - 1.6e-15 57.9 5.4 2.2e-15 57.5 5.4 1.2 1 0 0 1 1 1 1 SPX domain TFIIA PF03153.13 CDI76623.1 - 0.026 14.5 14.3 0.036 14.1 14.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Polysacc_synt_2 PF02719.15 CDI76623.1 - 0.052 12.7 0.4 0.083 12.0 0.4 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Fringe PF02434.16 CDI76624.1 - 8.5e-20 71.2 0.4 5.1e-10 39.2 0.0 3.3 2 1 0 2 2 2 2 Fringe-like DUF1357 PF07094.11 CDI76624.1 - 0.11 12.6 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1357) DUF5341 PF17276.2 CDI76624.1 - 0.16 12.1 0.5 0.29 11.3 0.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5341) SR-25 PF10500.9 CDI76624.1 - 0.17 11.5 4.6 0.35 10.4 4.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI76624.1 - 0.21 11.9 4.3 0.62 10.3 4.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF755) TFIIA PF03153.13 CDI76625.1 - 0.0015 18.6 44.0 0.41 10.6 12.7 3.4 2 1 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76625.1 - 0.035 13.7 31.7 0.089 12.4 4.9 3.3 3 0 0 3 3 3 0 Spt20 family Cwf_Cwc_15 PF04889.12 CDI76625.1 - 0.043 13.6 8.0 0.11 12.3 2.3 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein LMF1 PF06762.14 CDI76626.1 - 4.6e-23 82.0 0.0 6.1e-22 78.3 0.0 1.9 1 1 0 1 1 1 1 Lipase maturation factor Spt20 PF12090.8 CDI76626.1 - 0.0016 18.1 1.3 0.0016 18.1 1.3 2.1 2 0 0 2 2 2 1 Spt20 family SUIM_assoc PF16619.5 CDI76626.1 - 0.003 17.6 14.2 0.39 10.8 9.7 2.5 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 DoxX PF07681.12 CDI76626.1 - 0.0093 16.5 2.4 0.0093 16.5 2.4 2.0 2 0 0 2 2 2 1 DoxX ANAPC_CDC26 PF10471.9 CDI76626.1 - 0.035 14.9 12.4 0.3 11.9 4.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Cyt_c_ox_IV PF12270.8 CDI76626.1 - 0.055 13.6 3.6 0.097 12.8 3.1 1.6 1 1 1 2 2 2 0 Cytochrome c oxidase subunit IV EphA2_TM PF14575.6 CDI76626.1 - 0.1 13.5 0.0 0.1 13.5 0.0 2.1 3 0 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2722 PF10846.8 CDI76626.1 - 0.25 10.3 5.9 0.072 12.0 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Inj_translocase PF16928.5 CDI76626.1 - 0.31 10.5 11.6 0.79 9.1 4.7 2.2 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome tRNA_anti-like PF12869.7 CDI76626.1 - 0.46 10.1 2.8 1.6 8.3 3.1 1.6 2 0 0 2 2 2 0 tRNA_anti-like YajC PF02699.15 CDI76626.1 - 1.3 9.0 11.3 0.22 11.4 3.4 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit TFIIA PF03153.13 CDI76626.1 - 2.4 8.1 10.8 3 7.7 5.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit FTZ PF03867.14 CDI76626.1 - 7.1 6.1 12.8 0.37 10.3 6.8 1.7 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region DivIC PF04977.15 CDI76626.1 - 9.2 6.1 10.9 0.85 9.4 5.3 1.9 2 0 0 2 2 2 0 Septum formation initiator MID_MedPIWI PF18296.1 CDI76627.1 - 2 8.2 7.4 3.2 7.5 7.4 1.4 1 1 0 1 1 1 0 MID domain of medPIWI Peptidase_S64 PF08192.11 CDI76627.1 - 2.5 6.5 6.2 2.9 6.3 6.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 FSA_C PF10479.9 CDI76627.1 - 6.3 4.8 20.1 7.4 4.6 20.1 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus zf-RanBP PF00641.18 CDI76628.1 - 1.5e-06 27.4 5.2 1.5e-06 27.4 5.2 2.6 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Phostensin PF13914.6 CDI76628.1 - 0.22 12.2 0.1 0.22 12.2 0.1 4.3 4 2 1 5 5 5 0 Phostensin PP1-binding and SH3-binding region Dynamin_M PF01031.20 CDI76629.1 - 4.4e-79 265.7 0.3 5.8e-78 262.0 0.0 2.6 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 CDI76629.1 - 2.8e-48 164.2 0.1 1e-47 162.3 0.0 2.0 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 CDI76629.1 - 3e-15 56.1 0.0 1.1e-14 54.4 0.0 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CDI76629.1 - 0.0011 19.1 0.0 0.003 17.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4726 PF15855.5 CDI76629.1 - 0.015 15.5 1.2 0.015 15.5 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4726) SipA PF09052.10 CDI76629.1 - 0.058 13.0 0.2 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 SipA N-terminal domain MPM1 PF17234.2 CDI76629.1 - 2.3 8.5 7.1 0.079 13.2 0.5 1.8 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 PEN-2 PF10251.9 CDI76631.1 - 0.0012 19.2 0.8 0.022 15.2 0.1 2.6 1 1 1 2 2 2 1 Presenilin enhancer-2 subunit of gamma secretase SieB PF14163.6 CDI76631.1 - 0.29 10.6 17.0 1.2 8.6 16.7 2.1 1 1 0 1 1 1 0 Super-infection exclusion protein B SID-1_RNA_chan PF13965.6 CDI76631.1 - 0.87 7.9 9.6 0.16 10.3 6.3 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 IPK PF03770.16 CDI76635.1 - 7.6e-26 91.2 0.1 6e-15 55.6 0.0 3.8 3 2 0 3 3 3 2 Inositol polyphosphate kinase SPX PF03105.19 CDI76635.1 - 8.2 6.2 0.0 8.2 6.2 0.0 3.6 2 1 1 3 3 3 0 SPX domain GHL13 PF14883.6 CDI76637.1 - 0.041 12.9 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 LRR19-TM PF15176.6 CDI76639.1 - 0.74 9.8 5.5 2.4 8.2 5.5 1.8 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain FAM76 PF16046.5 CDI76639.1 - 1.1 8.5 19.9 3.2 7.0 19.9 1.8 1 0 0 1 1 1 0 FAM76 protein eIF-3_zeta PF05091.12 CDI76639.1 - 5.5 5.8 16.7 10 5.0 16.7 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SelR PF01641.18 CDI76640.1 - 6e-23 81.2 0.0 7.4e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 SelR domain Pyr_redox_2 PF07992.14 CDI76642.1 - 3.2e-37 128.4 0.0 4.3e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDI76642.1 - 6.8e-22 77.8 0.2 3.3e-14 53.1 0.1 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDI76642.1 - 2.6e-14 53.5 0.0 5.9e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI76642.1 - 8e-09 35.2 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CDI76642.1 - 0.0091 15.4 0.0 0.032 13.6 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.6 CDI76642.1 - 0.029 13.5 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) AP2 PF00847.20 CDI76643.1 - 7.3e-05 22.9 2.9 7.3e-05 22.9 2.9 2.9 2 0 0 2 2 2 1 AP2 domain DnaJ-X PF14308.6 CDI76644.1 - 6.3e-42 143.4 25.1 1.6e-22 80.0 9.1 3.6 2 1 1 3 3 3 2 X-domain of DnaJ-containing DnaJ PF00226.31 CDI76644.1 - 7.1e-25 86.9 1.7 1.1e-24 86.3 0.5 2.0 2 0 0 2 2 2 1 DnaJ domain ATG_C PF09333.11 CDI76644.1 - 2.3e-07 31.0 0.0 2.3e-07 31.0 0.0 3.8 4 1 1 5 5 5 1 Autophagy-related protein C terminal domain DUF755 PF05501.11 CDI76644.1 - 0.0021 18.3 7.4 0.0021 18.3 7.4 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI76644.1 - 0.0024 17.5 5.2 0.0024 17.5 5.2 3.8 4 0 0 4 4 4 2 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 CDI76644.1 - 0.042 14.7 0.9 0.042 14.7 0.9 6.3 4 2 2 6 6 6 0 Chorion family 2 Inhibitor_I71 PF12628.7 CDI76644.1 - 0.23 11.3 1.0 0.66 9.8 1.0 1.8 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Mito_carr PF00153.27 CDI76644.1 - 0.31 11.0 2.2 2.6 8.0 0.1 2.8 2 0 0 2 2 2 0 Mitochondrial carrier protein LUC7 PF03194.15 CDI76645.1 - 5e-63 213.1 7.8 5e-63 213.1 7.8 1.3 1 1 0 1 1 1 1 LUC7 N_terminus PRP38_assoc PF12871.7 CDI76645.1 - 0.024 15.2 31.7 0.024 15.2 31.7 3.1 2 1 1 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term NPV_P10 PF05531.12 CDI76645.1 - 0.031 14.7 2.1 6.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein IML1 PF12257.8 CDI76645.1 - 0.3 10.2 0.8 1.9 7.5 0.4 2.1 1 1 1 2 2 2 0 Vacuolar membrane-associated protein Iml1 DASH_Dad4 PF08650.10 CDI76645.1 - 0.38 10.8 0.1 0.38 10.8 0.1 2.6 2 1 1 3 3 3 0 DASH complex subunit Dad4 MnmE_helical PF12631.7 CDI76645.1 - 1 9.5 6.7 1.6 8.8 6.7 1.2 1 0 0 1 1 1 0 MnmE helical domain HSCB_C PF07743.13 CDI76645.1 - 1 9.9 13.6 0.11 13.0 4.1 3.2 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain Microtub_bind PF13931.6 CDI76645.1 - 1.5 9.2 10.6 1.9 8.9 1.5 2.2 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding FlgN PF05130.12 CDI76645.1 - 2 8.9 15.3 2.9 8.4 0.2 3.2 2 1 1 3 3 3 0 FlgN protein EMP24_GP25L PF01105.24 CDI76645.1 - 6.8 6.6 7.2 2.4e+02 1.5 7.2 2.7 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Cpn60_TCP1 PF00118.24 CDI76646.1 - 2.3e-147 491.6 6.3 2.7e-147 491.4 6.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3883 PF13020.6 CDI76647.1 - 1e-08 35.1 0.0 4.1e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3883) U1snRNP70_N PF12220.8 CDI76647.1 - 3.3 8.4 12.5 43 4.8 0.2 3.9 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal BT1 PF03092.16 CDI76648.1 - 1.3e-76 258.0 19.7 2.8e-53 181.0 13.4 2.0 1 1 1 2 2 2 2 BT1 family DUF2722 PF10846.8 CDI76649.1 - 0.00022 20.3 6.8 0.00022 20.3 6.8 15.8 8 6 3 12 12 12 2 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI76649.1 - 0.0019 18.9 5.1 0.0019 18.9 5.1 16.3 6 3 4 12 12 12 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Connexin PF00029.19 CDI76649.1 - 0.0022 17.8 0.6 0.0022 17.8 0.6 9.0 7 2 0 7 7 7 1 Connexin Apt1 PF10351.9 CDI76649.1 - 0.035 13.0 0.0 0.035 13.0 0.0 10.5 6 4 1 7 7 7 0 Golgi-body localisation protein domain RskA PF10099.9 CDI76649.1 - 7.2 6.9 0.0 0.62 10.3 11.6 19.2 2 2 10 14 14 14 0 Anti-sigma-K factor rskA MCM_N PF14551.6 CDI76651.1 - 4.1e-07 30.5 0.3 4.1e-07 30.5 0.3 1.7 2 1 0 2 2 2 1 MCM N-terminal domain HAGH_C PF16123.5 CDI76651.1 - 0.047 14.2 0.5 0.11 13.0 0.5 1.6 1 0 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus DUF2870 PF11069.8 CDI76651.1 - 2.7 8.5 7.1 0.28 11.6 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) MAS20 PF02064.15 CDI76651.1 - 5.3 7.2 10.6 9.1 6.4 6.0 2.4 1 1 1 2 2 2 0 MAS20 protein import receptor SR-25 PF10500.9 CDI76652.1 - 7.1 6.2 25.3 0.062 12.9 10.6 3.3 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein DUF89 PF01937.19 CDI76653.1 - 1.5e-26 93.2 0.0 1.2e-25 90.3 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function DUF89 TFIIA PF03153.13 CDI76653.1 - 0.0048 16.9 9.9 0.006 16.6 9.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit AP1AR PF15745.5 CDI76653.1 - 0.0051 16.5 0.9 0.0072 16.0 0.9 1.1 1 0 0 1 1 1 1 AP-1 complex-associated regulatory protein Spt20 PF12090.8 CDI76653.1 - 0.0076 15.9 13.6 0.011 15.4 13.6 1.2 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI76653.1 - 0.015 14.3 11.3 0.019 13.9 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RskA PF10099.9 CDI76653.1 - 0.09 13.1 9.7 0.26 11.6 9.6 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI76653.1 - 0.15 10.6 5.0 0.21 10.1 5.0 1.1 1 0 0 1 1 1 0 Macoilin family RBM39linker PF15519.6 CDI76653.1 - 0.18 12.9 4.5 0.35 12.0 4.5 1.4 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Folate_carrier PF01770.18 CDI76653.1 - 0.67 8.6 2.9 0.63 8.7 2.1 1.3 1 1 0 1 1 1 0 Reduced folate carrier Presenilin PF01080.17 CDI76653.1 - 1.1 7.9 4.8 1.6 7.4 4.8 1.2 1 0 0 1 1 1 0 Presenilin Med3 PF11593.8 CDI76653.1 - 2.7 7.1 14.6 0.15 11.2 8.7 1.9 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Orf78 PF06024.12 CDI76653.1 - 4.8 7.6 6.0 50 4.3 0.0 2.2 1 1 0 2 2 2 0 Orf78 (ac78) Conotoxin PF02950.17 CDI76653.1 - 5.3 8.1 6.5 6.1 7.9 2.6 2.5 2 0 0 2 2 2 0 Conotoxin Med15 PF09606.10 CDI76653.1 - 8.9 4.9 21.3 0.014 14.1 9.2 1.9 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF5304 PF17230.2 CDI76653.1 - 9.6 6.4 10.2 8.5 6.6 8.4 1.8 2 1 0 2 2 1 0 Family of unknown function (DUF5304) Histone_H2A_C PF16211.5 CDI76659.1 - 5.1e-19 67.7 0.3 5.1e-19 67.7 0.3 1.8 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 CDI76659.1 - 3.4e-15 56.6 0.0 4.4e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDI76659.1 - 6.9e-05 23.1 0.0 9.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDI76660.1 - 1.2e-54 184.2 1.4 1.3e-54 184.0 1.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDI76660.1 - 0.00024 21.7 0.9 0.00029 21.4 0.9 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDI76660.1 - 0.00039 20.5 0.1 0.00072 19.6 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDI76660.1 - 0.00046 20.5 0.0 0.00069 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDI76660.1 - 0.0065 16.7 0.5 0.01 16.1 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDI76660.1 - 0.016 15.3 0.1 0.027 14.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit TUSC2 PF15000.6 CDI76661.1 - 0.00013 22.2 0.0 0.00014 22.1 0.0 1.1 1 0 0 1 1 1 1 Tumour suppressor candidate 2 PGA2 PF07543.12 CDI76661.1 - 0.03 14.3 0.1 0.031 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 Spt20 PF12090.8 CDI76661.1 - 0.42 10.2 5.6 0.41 10.2 5.6 1.1 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 CDI76661.1 - 2.2 8.4 12.6 3.6 7.7 12.1 1.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pyr_redox_2 PF07992.14 CDI76662.1 - 6.9e-30 104.3 0.0 8.9e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDI76662.1 - 8.5e-06 26.3 0.0 0.0031 18.1 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDI76662.1 - 0.014 15.8 0.0 0.59 10.6 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CDI76662.1 - 0.12 11.6 0.0 1.2 8.3 0.0 2.3 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase MAM33 PF02330.16 CDI76663.1 - 3e-10 40.4 2.2 3e-10 40.4 2.2 2.7 1 1 1 2 2 2 1 Mitochondrial glycoprotein RskA PF10099.9 CDI76663.1 - 0.015 15.6 6.9 0.042 14.1 3.8 2.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI76663.1 - 0.021 14.4 9.5 0.027 14.1 9.5 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI76663.1 - 0.027 14.5 10.9 0.029 14.4 10.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YceG PF02618.16 CDI76663.1 - 0.036 13.6 1.3 0.048 13.2 1.3 1.2 1 0 0 1 1 1 0 YceG-like family DUF2802 PF10975.8 CDI76663.1 - 0.13 12.4 8.9 0.23 11.6 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) NUDIX PF00293.28 CDI76664.1 - 3.5e-11 43.3 0.0 5.5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain TFIIA PF03153.13 CDI76664.1 - 0.011 15.8 20.9 0.011 15.7 20.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI76664.1 - 0.43 9.2 26.4 0.49 9.0 26.4 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ribosomal_60s PF00428.19 CDI76664.1 - 0.93 10.1 15.9 1.5 9.4 7.1 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Coilin_N PF15862.5 CDI76664.1 - 1.4 8.7 9.6 2.1 8.1 9.6 1.4 1 0 0 1 1 1 0 Coilin N-terminus Suf PF05843.14 CDI76664.1 - 2.2 8.2 12.7 2.5 8.0 12.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pkinase PF00069.25 CDI76672.1 - 2.3e-23 82.9 0.5 8.1e-15 54.9 0.0 5.1 5 1 1 6 6 6 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76672.1 - 5.9e-11 42.2 0.3 5.4e-07 29.1 0.2 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase Ribosomal_60s PF00428.19 CDI76673.1 - 0.0051 17.4 10.7 0.0051 17.4 10.7 8.0 6 2 0 6 6 6 2 60s Acidic ribosomal protein PH_2 PF08458.10 CDI76673.1 - 0.17 12.2 0.0 0.61 10.5 0.0 1.9 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PRA1 PF03208.19 CDI76675.1 - 0.9 9.2 4.6 1.3 8.7 4.6 1.2 1 0 0 1 1 1 0 PRA1 family protein Peptidase_M20 PF01546.28 CDI76676.1 - 1.4e-14 54.3 0.0 4.9e-07 29.6 0.0 3.6 3 1 0 3 3 3 2 Peptidase family M20/M25/M40 WD40 PF00400.32 CDI76676.1 - 3.6e-07 30.8 12.9 0.19 12.7 0.9 6.3 5 1 0 5 5 5 3 WD domain, G-beta repeat M20_dimer PF07687.14 CDI76676.1 - 0.00021 21.1 0.0 0.0006 19.7 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain CKS PF01111.19 CDI76677.1 - 4.8e-21 74.8 0.0 1.1e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit RXT2_N PF08595.11 CDI76677.1 - 0.77 9.8 5.0 0.13 12.3 0.8 1.8 2 0 0 2 2 2 0 RXT2-like, N-terminal MFMR_assoc PF16596.5 CDI76677.1 - 0.97 9.9 5.9 0.34 11.4 1.4 2.5 2 0 0 2 2 2 0 Disordered region downstream of MFMR ALIX_LYPXL_bnd PF13949.6 CDI76679.1 - 0.33 10.2 5.0 0.056 12.7 0.8 1.8 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV DUF641 PF04859.12 CDI76680.1 - 0.084 13.2 0.6 0.24 11.8 0.6 1.7 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Shugoshin_N PF07558.11 CDI76680.1 - 0.13 12.2 1.5 0.3 11.0 1.5 1.7 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Meis_PKNOX_N PF16493.5 CDI76681.1 - 0.073 13.4 0.0 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 A_deaminase PF00962.22 CDI76682.1 - 8.9e-52 176.4 0.0 9.8e-52 176.3 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF3854 PF12965.7 CDI76684.1 - 0.5 10.3 0.0 0.5 10.3 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3854) tRNA-synt_2c PF01411.19 CDI76688.1 - 7.9e-186 618.8 0.0 5.5e-185 616.0 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CDI76688.1 - 7.2e-17 61.2 0.0 1.6e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CDI76688.1 - 8.6e-05 23.0 2.1 0.00022 21.6 2.1 1.7 1 0 0 1 1 1 1 DHHA1 domain RRM_1 PF00076.22 CDI76689.1 - 5.1e-27 93.5 0.1 2.8e-15 55.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI76689.1 - 4e-06 26.9 0.2 0.0022 18.1 0.1 2.7 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDI76689.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif B12-binding PF02310.19 CDI76689.1 - 0.076 13.1 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 B12 binding domain MMR_HSR1 PF01926.23 CDI76691.1 - 0.15 12.2 0.0 0.49 10.5 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDI76691.1 - 0.2 11.7 0.0 1 9.4 0.0 2.1 2 0 0 2 2 2 0 Dynamin family BSD PF03909.17 CDI76692.1 - 0.0023 17.9 0.3 0.0046 16.9 0.3 1.5 1 0 0 1 1 1 1 BSD domain WD40 PF00400.32 CDI76696.1 - 0.00012 22.8 1.6 3.5 8.6 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat SopA_C PF13979.6 CDI76697.1 - 0.0052 16.5 0.1 0.17 11.6 0.0 2.2 2 0 0 2 2 2 2 SopA-like catalytic domain Rad51 PF08423.11 CDI76698.1 - 3.9e-18 65.6 0.1 1.1e-17 64.2 0.0 1.7 1 1 1 2 2 2 1 Rad51 DEK_C PF08766.11 CDI76699.1 - 1.5e-05 24.8 2.4 2.8e-05 24.0 2.4 1.5 1 0 0 1 1 1 1 DEK C terminal domain PhageMin_Tail PF10145.9 CDI76699.1 - 0.02 14.7 0.6 0.029 14.2 0.6 1.3 1 0 0 1 1 1 0 Phage-related minor tail protein Nucleopor_Nup85 PF07575.13 CDI76699.1 - 0.023 13.3 0.5 0.025 13.2 0.5 1.1 1 0 0 1 1 1 0 Nup85 Nucleoporin DUF4611 PF15387.6 CDI76699.1 - 0.42 10.9 10.9 0.66 10.2 10.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) Sigma70_ner PF04546.13 CDI76699.1 - 0.98 9.3 11.7 0.93 9.3 10.7 1.5 1 1 0 1 1 1 0 Sigma-70, non-essential region Dicty_REP PF05086.12 CDI76699.1 - 2.9 5.8 7.7 3.7 5.4 7.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Vfa1 PF08432.10 CDI76699.1 - 4.4 7.6 10.0 5.7 7.2 10.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1645 PF07816.11 CDI76701.1 - 0.011 16.4 7.1 0.011 16.4 7.1 7.3 6 2 2 8 8 8 0 Protein of unknown function (DUF1645) DUF3006 PF11213.8 CDI76701.1 - 2.8 8.2 4.4 0.71 10.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) AP2 PF00847.20 CDI76705.1 - 1.1e-10 41.6 1.3 1.1e-10 41.6 1.3 3.1 4 0 0 4 4 4 1 AP2 domain PA26 PF04636.13 CDI76705.1 - 4.6 6.1 11.9 6.1 5.7 0.3 2.6 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF5523 PF17661.1 CDI76705.1 - 8.6 6.0 16.6 1.8 8.2 2.4 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5523) AAA_23 PF13476.6 CDI76707.1 - 0.0021 18.6 3.2 0.0037 17.8 3.2 1.5 1 0 0 1 1 1 1 AAA domain SR-25 PF10500.9 CDI76707.1 - 0.0091 15.6 9.2 0.0091 15.6 9.2 5.2 4 2 1 5 5 5 2 Nuclear RNA-splicing-associated protein ABC2_membrane_2 PF12679.7 CDI76707.1 - 0.14 11.5 7.5 0.028 13.7 0.5 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 CDI76707.1 - 1.7 7.6 4.5 3.1 6.8 4.5 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein F-box PF00646.33 CDI76707.1 - 3.9 7.5 8.3 10 6.1 8.3 1.7 1 0 0 1 1 1 0 F-box domain TFIIA PF03153.13 CDI76707.1 - 6 6.8 51.1 0.61 10.0 32.5 2.7 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit FAP PF07174.11 CDI76708.1 - 0.25 10.8 11.2 0.28 10.6 11.2 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) ATG_C PF09333.11 CDI76708.1 - 0.25 11.7 5.5 0.35 11.2 5.5 1.2 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain DUF4813 PF16072.5 CDI76708.1 - 1.2 8.7 16.9 1.5 8.5 16.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) AAA PF00004.29 CDI76710.1 - 3.7e-15 56.5 1.2 8.1e-15 55.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI76710.1 - 3.2e-06 26.8 0.3 0.09 12.6 0.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain AAA_33 PF13671.6 CDI76710.1 - 0.041 14.1 0.0 0.041 14.1 0.0 4.6 5 2 0 5 5 5 0 AAA domain AAA_17 PF13207.6 CDI76710.1 - 0.06 13.8 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 CDI76710.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.4 2 0 0 2 2 2 0 Cytidylate kinase EB1 PF03271.17 CDI76712.1 - 1.6e-12 47.4 0.0 3.1e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 CDI76712.1 - 2e-05 24.7 0.3 3e-05 24.2 0.3 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF1932 PF09130.11 CDI76713.1 - 0.017 15.1 1.0 0.9 9.6 0.2 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1932) zf-CCCH PF00642.24 CDI76714.1 - 2e-10 40.3 20.8 0.0011 18.8 4.0 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI76714.1 - 3.7e-08 33.2 26.1 0.00018 21.4 3.7 3.7 3 1 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 CDI76714.1 - 0.00019 21.2 20.5 0.013 15.3 4.3 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CDI76714.1 - 0.00021 21.5 14.9 0.00076 19.7 3.6 3.7 2 1 1 3 3 3 2 Zinc-finger containing family Torus PF16131.5 CDI76714.1 - 0.00027 21.6 1.9 0.00027 21.6 1.9 5.6 3 1 2 5 5 5 3 Torus domain zf-CCCH_2 PF14608.6 CDI76714.1 - 6.8 7.3 19.9 3.2 8.4 1.3 3.5 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger U-box PF04564.15 CDI76718.1 - 1e-13 51.2 0.1 4.4e-13 49.2 0.0 2.1 2 0 0 2 2 2 1 U-box domain TPR_1 PF00515.28 CDI76718.1 - 8.8e-12 44.3 5.1 6.2e-05 22.6 0.4 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDI76718.1 - 2.3e-10 39.7 6.5 0.00032 20.6 0.8 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDI76718.1 - 1.3e-06 28.2 1.9 0.021 15.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI76718.1 - 5.5e-06 26.9 6.2 7.5e-05 23.3 1.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDI76718.1 - 2.6e-05 24.4 5.2 0.051 13.9 0.3 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI76718.1 - 3.8e-05 23.8 0.8 6.9e-05 23.0 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDI76718.1 - 4.4e-05 23.1 3.3 0.13 12.0 0.5 2.8 1 1 2 3 3 3 2 TPR repeat TPR_9 PF13371.6 CDI76718.1 - 0.0008 19.5 0.2 0.0008 19.5 0.2 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-NOSIP PF15906.5 CDI76718.1 - 0.024 14.8 0.0 0.068 13.3 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_19 PF14559.6 CDI76718.1 - 0.061 13.8 2.9 0.08 13.5 0.9 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDI76718.1 - 0.18 12.2 0.2 34 5.1 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDI76718.1 - 0.22 11.7 3.2 67 3.9 0.2 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI76718.1 - 0.23 12.4 4.3 23 6.1 0.0 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat ubiquitin PF00240.23 CDI76719.1 - 2.6e-34 116.8 0.3 3.6e-34 116.3 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CDI76719.1 - 5.9e-30 102.9 11.2 9e-30 102.3 11.2 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CDI76719.1 - 6.8e-17 61.1 0.5 1e-16 60.5 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDI76719.1 - 3.3e-06 27.5 0.1 1.2e-05 25.7 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDI76719.1 - 0.004 17.1 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CDI76719.1 - 0.011 16.1 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDI76719.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CDI76719.1 - 0.025 14.6 0.8 5.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 CDI76719.1 - 0.044 14.4 0.0 0.053 14.1 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Surface_antigen PF11054.8 CDI76720.1 - 2.4e-32 112.5 5.2 4.2e-32 111.8 5.2 1.3 1 1 0 1 1 1 1 Sporozoite TA4 surface antigen FAD_binding_4 PF01565.23 CDI76721.1 - 1.9e-33 115.1 0.2 3.1e-33 114.5 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 CDI76721.1 - 1.2e-29 103.7 0.0 1e-28 100.6 0.0 2.0 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain PARG_cat PF05028.14 CDI76722.1 - 1.1e-09 38.0 0.0 1.9e-09 37.3 0.0 1.3 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) SNARE_assoc PF09335.11 CDI76723.1 - 2.1e-15 57.3 6.0 2.1e-15 57.3 6.0 2.6 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF3087 PF11286.8 CDI76723.1 - 0.23 10.9 1.9 0.25 10.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Abhydrolase_9_N PF15420.6 CDI76723.1 - 6.8 6.6 11.0 0.56 10.2 4.8 2.3 2 2 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus EMG1 PF03587.14 CDI76724.1 - 1.8e-62 210.5 0.1 2.2e-62 210.2 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Antistasin PF02822.14 CDI76725.1 - 0.52 11.0 5.4 0.8 10.4 5.4 1.3 1 0 0 1 1 1 0 Antistasin family Asp-B-Hydro_N PF05279.11 CDI76725.1 - 2.6 8.0 40.3 3.5 7.6 40.3 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CRAL_TRIO PF00650.20 CDI76726.1 - 1.3e-05 24.9 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain STAS PF01740.21 CDI76726.1 - 0.18 11.4 0.0 0.5 10.0 0.0 1.7 2 0 0 2 2 2 0 STAS domain DUF4533 PF15047.6 CDI76726.1 - 0.21 11.1 0.0 3.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4533) DUF4064 PF13273.6 CDI76727.1 - 0.006 16.8 0.8 1.4 9.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4064) FixS PF03597.15 CDI76727.1 - 0.12 12.1 0.7 0.33 10.7 0.7 1.6 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type zf-RING_2 PF13639.6 CDI76728.1 - 7.4e-09 35.8 12.4 7.4e-09 35.8 12.4 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 CDI76728.1 - 2.2e-06 27.9 8.3 2.2e-06 27.9 8.3 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDI76728.1 - 1.2e-05 24.9 1.0 1.2e-05 24.9 1.0 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI76728.1 - 2.7e-05 23.9 12.4 5.1e-05 23.0 11.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI76728.1 - 0.0013 18.5 7.1 0.0013 18.5 7.1 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI76728.1 - 0.0029 17.6 3.4 0.0029 17.6 3.4 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDI76728.1 - 0.012 15.5 8.9 0.012 15.5 8.9 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI76728.1 - 0.012 15.5 10.2 0.012 15.5 10.2 2.1 2 0 0 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDI76728.1 - 0.066 12.8 10.2 0.16 11.6 10.2 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDI76728.1 - 0.09 12.8 5.3 0.19 11.8 5.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger CDC48_2 PF02933.17 CDI76728.1 - 0.13 12.0 0.3 2.1 8.2 0.0 2.7 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 zf-RING_4 PF14570.6 CDI76728.1 - 1.4 8.7 5.5 3.9 7.4 5.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Eapp_C PF10238.9 CDI76728.1 - 9.8 6.2 9.4 1.9 8.5 4.5 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein PARG_cat PF05028.14 CDI76729.1 - 3.6e-79 266.5 0.0 5.2e-79 266.0 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Radial_spoke_3 PF06098.11 CDI76731.1 - 3.3e-10 39.7 10.6 5.4e-10 39.0 10.6 1.2 1 0 0 1 1 1 1 Radial spoke protein 3 RE_BstXI PF09552.10 CDI76731.1 - 0.0029 16.9 1.4 0.74 8.9 0.0 2.2 2 0 0 2 2 2 2 BstXI restriction endonuclease KOG2701 PF09762.9 CDI76731.1 - 0.073 13.3 1.9 0.13 12.5 1.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) FAM178 PF14816.6 CDI76731.1 - 0.12 11.4 5.4 0.17 10.9 5.4 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 TRM13 PF05206.14 CDI76733.1 - 3.8e-20 72.5 0.2 1.5e-07 31.2 0.0 5.0 4 1 1 5 5 5 3 Methyltransferase TRM13 zf-U11-48K PF05253.12 CDI76733.1 - 9e-06 25.5 0.1 1.8e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger DUF775 PF05603.12 CDI76733.1 - 0.21 11.1 1.0 0.52 9.8 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Vac14_Fig4_bd PF11916.8 CDI76734.1 - 3.1e-39 134.5 0.0 1.2e-38 132.6 0.0 2.0 1 1 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 CDI76734.1 - 3.3e-12 46.9 0.1 5.4e-11 42.9 0.0 2.9 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 CDI76734.1 - 0.0074 16.5 0.1 3.9 8.0 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat PPR PF01535.20 CDI76735.1 - 1.2e-09 37.8 6.2 0.017 15.4 0.1 6.3 7 0 0 7 7 7 2 PPR repeat PPR_2 PF13041.6 CDI76735.1 - 2e-09 37.5 0.1 5.7e-05 23.2 0.0 4.6 4 1 1 5 5 5 2 PPR repeat family PPR_long PF17177.4 CDI76735.1 - 1.4e-07 31.1 0.0 1.4e-07 31.1 0.0 3.5 3 2 1 4 4 4 1 Pentacotripeptide-repeat region of PRORP DcuA_DcuB PF03605.14 CDI76735.1 - 0.012 14.6 2.8 0.027 13.4 2.8 1.6 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter TPR_3 PF07720.12 CDI76735.1 - 0.034 14.2 1.6 0.29 11.2 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI76735.1 - 0.88 9.8 6.3 3.2 8.1 0.2 4.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDI76735.1 - 4.1 7.6 10.7 0.25 11.5 0.3 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat SF3A2 PF16835.5 CDI76736.1 - 1.1e-35 121.8 0.0 1.7e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CDI76736.1 - 3.3e-07 30.5 1.4 6.1e-07 29.6 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 CDI76736.1 - 0.0082 16.1 0.1 0.013 15.4 0.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Glyoxalase PF00903.25 CDI76737.1 - 1.5e-10 41.4 0.0 4e-08 33.5 0.0 2.9 3 0 0 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDI76737.1 - 0.016 15.5 0.1 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily eIF-3_zeta PF05091.12 CDI76742.1 - 0.75 8.7 19.8 1.1 8.2 19.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI76742.1 - 2.7 8.0 10.1 5 7.1 10.1 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 CDI76742.1 - 7.7 4.6 35.7 10 4.2 35.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hydin_ADK PF17213.3 CDI76742.1 - 7.8 6.7 9.4 15 5.8 9.4 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain FtsJ PF01728.19 CDI76744.1 - 1e-18 68.1 0.0 4.4e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 FtsJ-like methyltransferase SUIM_assoc PF16619.5 CDI76744.1 - 0.007 16.4 0.8 0.007 16.4 0.8 6.3 6 1 0 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 Ctr PF04145.15 CDI76744.1 - 1.8 9.1 3.7 1 9.9 0.2 2.4 3 0 0 3 3 3 0 Ctr copper transporter family Mito_carr PF00153.27 CDI76745.1 - 1.3e-58 194.9 5.1 5.7e-24 83.9 0.4 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein AAA PF00004.29 CDI76746.1 - 1.1e-05 25.8 0.0 3e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 CDI76746.1 - 0.0046 17.1 0.0 0.0046 17.1 0.0 2.4 2 0 0 2 2 2 1 AAA lid domain NACHT PF05729.12 CDI76746.1 - 0.065 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 CDI76746.1 - 0.19 12.1 3.1 1.3 9.4 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain FERM_F1 PF18379.1 CDI76746.1 - 0.2 11.7 0.0 0.51 10.4 0.0 1.6 1 0 0 1 1 1 0 FERM F1 ubiquitin-like domain DUF1645 PF07816.11 CDI76746.1 - 3.4 8.2 29.8 0.025 15.2 9.7 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI76746.1 - 4.1 6.9 11.3 9.4 5.8 11.3 1.7 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI76746.1 - 8 6.3 23.4 3.6 7.5 11.6 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit NolX PF05819.11 CDI76746.1 - 9.8 5.4 17.9 21 4.3 17.9 1.5 1 0 0 1 1 1 0 NolX protein CDC50 PF03381.15 CDI76747.1 - 9.8e-17 61.4 0.0 2.1e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family RR_TM4-6 PF06459.12 CDI76748.1 - 0.068 13.0 29.7 0.084 12.7 29.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI76748.1 - 0.21 9.8 47.9 0.26 9.5 47.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI76748.1 - 0.31 8.1 33.4 0.34 8.0 33.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CAC1F_C PF16885.5 CDI76748.1 - 0.35 10.5 25.0 0.43 10.2 25.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term RIFIN PF02009.16 CDI76748.1 - 0.45 10.3 20.6 0.52 10.2 20.6 1.1 1 0 0 1 1 1 0 Rifin DUF5427 PF10310.9 CDI76748.1 - 0.47 9.3 29.7 0.66 8.9 29.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Macoilin PF09726.9 CDI76748.1 - 0.86 8.1 26.5 1.1 7.7 26.5 1.1 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 CDI76748.1 - 1.1 8.3 30.4 1.4 7.9 30.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CDI76748.1 - 3.3 6.4 22.6 5.1 5.8 22.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4045 PF13254.6 CDI76748.1 - 3.4 7.2 27.1 4.8 6.7 27.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CDK5_activator PF03261.15 CDI76748.1 - 4.4 6.8 29.0 5.1 6.5 29.0 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF1387 PF07139.11 CDI76748.1 - 7.2 6.3 32.1 9.4 5.9 32.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CCSAP PF15748.5 CDI76748.1 - 8.4 6.5 39.9 11 6.1 39.9 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PIP5K PF01504.18 CDI76756.1 - 1.8e-40 138.9 0.5 3.2e-40 138.1 0.5 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.32 CDI76756.1 - 0.00017 20.9 1.6 0.00033 20.0 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDI76756.1 - 0.0017 18.8 0.0 0.0059 17.0 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI76756.1 - 0.0063 16.3 0.1 0.033 14.1 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain GvpK PF05121.12 CDI76756.1 - 0.49 10.5 3.9 1.5 9.0 3.9 1.7 1 0 0 1 1 1 0 Gas vesicle protein K RRM_1 PF00076.22 CDI76757.1 - 1.8e-36 123.8 0.2 7.2e-14 51.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 CDI76757.1 - 9.8e-06 26.6 0.1 9.8e-06 26.6 0.1 2.7 2 0 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 CDI76757.1 - 1.1e-05 25.2 0.0 0.14 12.0 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 CDI76757.1 - 0.028 14.5 0.0 6.5 6.9 0.0 2.8 2 0 0 2 2 2 0 RNA binding motif DUF1866 PF08952.11 CDI76757.1 - 0.037 13.9 0.0 0.094 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) DbpA PF03880.15 CDI76757.1 - 0.2 11.7 0.9 21 5.2 0.0 3.4 3 0 0 3 3 3 0 DbpA RNA binding domain AAA_11 PF13086.6 CDI76759.1 - 8.3e-53 179.8 11.8 4.9e-29 101.9 0.9 4.5 4 1 1 5 5 5 3 AAA domain AAA_12 PF13087.6 CDI76759.1 - 3.5e-36 124.7 0.0 2.5e-20 72.9 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 CDI76759.1 - 1.8e-10 40.9 1.8 8.9e-05 22.3 0.1 3.0 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 CDI76759.1 - 3.3e-10 40.5 0.0 0.0015 18.8 0.0 2.8 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 CDI76759.1 - 0.0013 18.6 0.1 0.04 13.7 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CDI76759.1 - 0.016 14.8 0.2 2.5 7.5 0.1 3.1 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_29 PF13555.6 CDI76759.1 - 0.085 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 CDI76759.1 - 0.2 12.1 0.1 0.47 10.9 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI76759.1 - 0.42 11.0 4.2 0.37 11.2 0.2 3.0 3 1 1 4 4 4 0 AAA ATPase domain PNTB PF02233.16 CDI76761.1 - 1.4e-178 594.6 21.6 1.4e-178 594.6 21.6 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CDI76761.1 - 8.5e-67 224.6 0.5 2e-66 223.3 0.5 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDI76761.1 - 1.1e-29 103.4 0.0 2.3e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CDI76761.1 - 3.3e-20 72.3 6.4 3.3e-20 72.3 6.4 4.6 4 1 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 CDI76761.1 - 3.5e-06 26.5 0.4 0.079 12.3 0.2 2.4 1 1 1 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 CDI76761.1 - 0.0059 16.3 0.5 0.094 12.5 0.1 3.0 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain GIDA PF01134.22 CDI76761.1 - 1.5 7.8 4.0 0.48 9.4 1.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A NUDE_C PF04880.13 CDI76762.1 - 0.0031 18.0 3.6 0.0031 18.0 3.6 4.1 4 1 1 5 5 5 1 NUDE protein, C-terminal conserved region DUF1828 PF08861.10 CDI76762.1 - 0.057 13.7 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF1828 NYN_YacP PF05991.11 CDI76762.1 - 3.8 7.4 5.8 2.1 8.3 0.1 2.8 2 0 0 2 2 2 0 YacP-like NYN domain MIF4G_like_2 PF09090.11 CDI76762.1 - 8.5 5.8 10.2 0.17 11.3 1.4 2.6 2 0 0 2 2 2 0 MIF4G like SNF2_N PF00176.23 CDI76763.1 - 6.5e-43 146.8 0.2 9.5e-34 116.6 0.2 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI76763.1 - 2e-17 63.5 0.0 2e-17 63.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI76763.1 - 4.2e-09 36.6 0.5 1.9e-08 34.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDI76763.1 - 0.0013 18.5 0.0 0.0013 18.5 0.0 1.8 2 0 0 2 2 1 1 DEAD/DEAH box helicase PAP_RNA-bind PF04926.15 CDI76763.1 - 0.73 9.4 5.6 2.1 8.0 5.6 1.7 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain TFIIA PF03153.13 CDI76763.1 - 0.89 9.5 31.8 0.031 14.3 23.2 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CNDH2_C PF16858.5 CDI76763.1 - 0.92 9.3 13.7 0.65 9.8 9.0 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Peptidase_S49_N PF08496.10 CDI76763.1 - 1.2 9.2 6.8 0.68 10.0 4.6 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4746 PF15928.5 CDI76763.1 - 1.7 8.0 5.2 3.7 6.9 5.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ALMT PF11744.8 CDI76763.1 - 1.8 7.3 7.3 9.8 4.9 7.5 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Connexin PF00029.19 CDI76763.1 - 1.8 8.2 3.5 4.6 6.9 3.5 1.7 1 0 0 1 1 1 0 Connexin Peptidase_U57 PF05582.12 CDI76763.1 - 1.9 7.7 6.5 3.4 6.9 6.5 1.3 1 0 0 1 1 1 0 YabG peptidase U57 SpoIIP PF07454.11 CDI76763.1 - 4.4 6.7 10.1 10 5.5 10.1 1.6 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RRM_1 PF00076.22 CDI76767.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spt20 PF12090.8 CDI76768.1 - 0.00017 21.3 7.4 0.00017 21.3 7.4 2.1 2 0 0 2 2 2 1 Spt20 family p25-alpha PF05517.12 CDI76768.1 - 0.0035 17.5 0.1 0.0035 17.5 0.1 2.0 2 0 0 2 2 2 1 p25-alpha Caskin-Pro-rich PF16907.5 CDI76768.1 - 0.092 13.3 0.3 0.092 13.3 0.3 2.2 2 0 0 2 2 2 0 Proline rich region of Caskin proteins Androgen_recep PF02166.16 CDI76768.1 - 0.32 9.8 12.7 0.15 10.9 9.6 1.9 2 0 0 2 2 2 0 Androgen receptor ILVD_EDD PF00920.21 CDI76768.1 - 0.34 9.5 2.0 0.58 8.7 2.0 1.3 1 0 0 1 1 1 0 Dehydratase family SARAF PF06682.12 CDI76768.1 - 0.61 9.7 6.2 2.3 7.8 0.6 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis PA26 PF04636.13 CDI76768.1 - 0.79 8.6 9.5 3 6.7 0.2 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF4834 PF16118.5 CDI76768.1 - 0.8 10.7 13.2 0.14 13.2 3.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CPSF100_C PF13299.6 CDI76768.1 - 0.89 9.7 13.2 0.73 10.0 0.4 2.4 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SLC12 PF03522.15 CDI76768.1 - 1.2 8.1 6.8 3.4 6.6 0.4 2.1 2 0 0 2 2 2 0 Solute carrier family 12 ANAPC_CDC26 PF10471.9 CDI76768.1 - 2.2 9.2 23.7 1.8 9.5 13.9 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 BAT2_N PF07001.11 CDI76768.1 - 2.4 8.6 10.9 0.62 10.5 1.9 2.3 2 1 0 2 2 2 0 BAT2 N-terminus DUF2722 PF10846.8 CDI76768.1 - 2.7 6.8 20.6 0.19 10.7 12.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI76768.1 - 3.6 7.5 25.6 0.66 9.9 12.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 CDI76768.1 - 7 5.7 13.9 11 5.0 13.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SpoIIP PF07454.11 CDI76768.1 - 7.6 5.9 11.6 0.5 9.8 0.8 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF5327 PF17261.2 CDI76768.1 - 10 7.0 20.4 0.99 10.2 4.0 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5327) SUIM_assoc PF16619.5 CDI76771.1 - 0.0023 18.0 11.9 0.012 15.7 3.1 4.0 4 0 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 FHA PF00498.26 CDI76771.1 - 0.007 16.7 0.1 0.012 15.9 0.1 1.4 1 0 0 1 1 1 1 FHA domain DUF3040 PF11239.8 CDI76771.1 - 0.064 13.5 0.4 0.064 13.5 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) NCOA_u2 PF16665.5 CDI76771.1 - 0.63 10.4 3.6 4.2 7.7 0.5 2.3 2 0 0 2 2 2 0 Unstructured region on nuclear receptor coactivator protein Spt20 PF12090.8 CDI76771.1 - 1.8 8.1 20.5 1.9 8.0 2.2 2.6 3 0 0 3 3 3 0 Spt20 family DUF2722 PF10846.8 CDI76771.1 - 2 7.3 11.5 1.7 7.5 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) RskA PF10099.9 CDI76771.1 - 9.7 6.4 50.9 7.5 6.8 16.3 2.5 1 1 0 2 2 2 0 Anti-sigma-K factor rskA RRM_1 PF00076.22 CDI76772.1 - 0.011 15.5 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI76772.1 - 0.029 14.2 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif SARAF PF06682.12 CDI76772.1 - 2.6 7.6 25.2 0.15 11.7 10.5 2.5 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Lyase_8 PF02278.18 CDI76772.1 - 4.6 6.6 6.8 0.51 9.8 2.0 1.7 2 0 0 2 2 2 0 Polysaccharide lyase family 8, super-sandwich domain FAM184 PF15665.5 CDI76774.1 - 0.0029 17.4 36.1 0.0029 17.4 36.1 5.4 1 1 3 5 5 5 1 Family with sequence similarity 184, A and B DUF3800 PF12686.7 CDI76774.1 - 0.14 12.8 0.0 15 6.3 0.0 3.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Utp14 PF04615.13 CDI76775.1 - 0.34 9.4 38.0 0.0041 15.8 4.5 4.2 3 1 0 3 3 3 0 Utp14 protein SID-1_RNA_chan PF13965.6 CDI76775.1 - 2.2 6.6 9.8 0.78 8.1 3.0 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF2722 PF10846.8 CDI76776.1 - 0.0034 16.4 0.0 0.0034 16.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF3464 PF11947.8 CDI76776.1 - 0.018 14.8 1.5 0.49 10.1 0.0 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 ALG11_N PF15924.5 CDI76778.1 - 1e-19 71.5 0.6 2e-07 31.3 0.1 4.5 4 0 0 4 4 4 3 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CDI76778.1 - 7.8e-10 38.5 0.2 4.5e-06 26.3 0.1 2.7 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDI76778.1 - 0.0002 21.8 3.0 0.00059 20.3 0.5 2.8 2 1 1 3 3 3 1 Glycosyl transferases group 1 Miga PF10265.9 CDI76778.1 - 0.0082 15.2 16.2 0.011 14.8 2.7 2.7 2 0 0 2 2 2 2 Mitoguardin Mem_trans PF03547.18 CDI76778.1 - 0.069 11.5 0.3 2.5 6.4 0.0 2.2 2 0 0 2 2 2 0 Membrane transport protein Tim54 PF11711.8 CDI76778.1 - 0.22 10.3 18.7 0.69 8.6 4.0 2.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 CDI76778.1 - 0.24 10.3 15.6 0.58 9.1 3.6 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) TMEM223 PF14640.6 CDI76778.1 - 0.89 9.7 8.8 3 8.0 0.3 3.7 3 0 0 3 3 3 0 Transmembrane protein 223 CLN3 PF02487.17 CDI76778.1 - 1 8.3 20.6 0.97 8.4 3.2 3.3 3 0 0 3 3 3 0 CLN3 protein DUF4781 PF16013.5 CDI76778.1 - 2.8 6.7 0.0 2.8 6.7 0.0 3.6 4 0 0 4 4 3 0 Domain of unknown function (DUF4781) CDC45 PF02724.14 CDI76778.1 - 5.1 5.3 25.1 0.29 9.4 4.6 2.3 2 0 0 2 2 2 0 CDC45-like protein CBFD_NFYB_HMF PF00808.23 CDI76779.1 - 5.4e-06 26.6 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDI76779.1 - 0.00039 20.8 0.1 0.00039 20.8 0.1 4.8 4 1 0 4 4 4 1 Core histone H2A/H2B/H3/H4 DUF572 PF04502.13 CDI76779.1 - 6.7 6.2 53.6 0.21 11.1 10.8 4.1 4 0 0 4 4 4 0 Family of unknown function (DUF572) Arm PF00514.23 CDI76780.1 - 1.8e-80 262.8 25.1 6e-14 51.5 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDI76780.1 - 9.8e-20 70.7 22.9 1.7e-07 31.6 0.0 7.0 6 3 2 8 8 7 3 HEAT-like repeat Arm_3 PF16186.5 CDI76780.1 - 1.8e-15 56.2 0.0 9.3e-15 53.9 0.1 2.1 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_2 PF13646.6 CDI76780.1 - 2.1e-15 56.9 8.3 2.3e-05 24.7 0.0 5.4 3 1 5 8 8 6 5 HEAT repeats HEAT PF02985.22 CDI76780.1 - 1.3e-12 46.8 7.4 0.00021 21.3 0.0 7.8 8 0 0 8 8 8 2 HEAT repeat NopRA1 PF16201.5 CDI76780.1 - 1.1e-05 25.1 0.0 0.4 10.2 0.0 4.2 2 1 2 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 V-ATPase_H_C PF11698.8 CDI76780.1 - 9.1e-05 22.5 0.0 6.6 6.9 0.0 3.7 4 0 0 4 4 4 2 V-ATPase subunit H Atx10homo_assoc PF09759.9 CDI76780.1 - 0.00017 21.6 0.0 0.22 11.5 0.0 2.7 2 0 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain RICTOR_V PF14668.6 CDI76780.1 - 0.00053 20.2 1.0 0.57 10.5 0.1 4.3 4 2 2 6 6 6 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 CDI76780.1 - 0.00076 19.0 0.0 0.22 10.9 0.0 2.3 1 1 1 2 2 2 2 Armadillo-like Adaptin_N PF01602.20 CDI76780.1 - 0.0052 15.4 0.0 1.2 7.6 0.0 3.0 1 1 0 2 2 2 1 Adaptin N terminal region HEAT_PBS PF03130.16 CDI76780.1 - 0.0058 17.2 7.6 0.42 11.4 0.0 6.2 8 0 0 8 8 5 1 PBS lyase HEAT-like repeat Gcn1_N PF12074.8 CDI76780.1 - 0.049 12.9 0.0 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DUF5557 PF17712.1 CDI76780.1 - 0.084 12.8 0.1 0.78 9.7 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5557) UNC45-central PF11701.8 CDI76780.1 - 0.1 12.6 0.5 34 4.4 0.1 3.3 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central SOBP PF15279.6 CDI76781.1 - 0.0023 18.6 30.4 0.0025 18.5 30.4 1.1 1 0 0 1 1 1 1 Sine oculis-binding protein LAP1C PF05609.12 CDI76781.1 - 0.0088 15.2 36.6 0.01 15.0 36.6 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Nop53 PF07767.11 CDI76781.1 - 0.011 15.2 47.8 0.014 14.8 47.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PAT1 PF09770.9 CDI76781.1 - 0.014 13.7 45.1 0.019 13.3 45.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI76781.1 - 0.015 12.5 37.0 0.017 12.3 37.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PI3K_1B_p101 PF10486.9 CDI76781.1 - 1.5 6.5 31.7 1.8 6.2 31.7 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MCM_bind PF09739.9 CDI76781.1 - 3.2 6.1 40.7 0.5 8.8 27.7 2.0 1 1 1 2 2 2 0 Mini-chromosome maintenance replisome factor LMBR1 PF04791.16 CDI76781.1 - 3.9 6.3 22.5 5.1 5.9 22.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Hamartin PF04388.12 CDI76781.1 - 4.6 5.8 37.4 5.7 5.5 37.4 1.1 1 0 0 1 1 1 0 Hamartin protein Dicty_REP PF05086.12 CDI76781.1 - 4.8 5.0 27.3 6.4 4.6 27.3 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CDK5_activator PF03261.15 CDI76781.1 - 5 6.6 36.9 6.3 6.2 36.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Caldesmon PF02029.15 CDI76781.1 - 5.9 5.5 49.7 7.4 5.2 49.7 1.0 1 0 0 1 1 1 0 Caldesmon GET2 PF08690.10 CDI76781.1 - 7.6 6.1 34.4 10 5.6 34.4 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 BLM10_mid PF16507.5 CDI76782.1 - 4e-09 35.7 0.0 8.8e-06 24.6 0.0 2.9 2 1 0 2 2 2 2 Proteasome-substrate-size regulator, mid region DUF2722 PF10846.8 CDI76782.1 - 0.00012 21.2 9.6 0.033 13.1 0.9 3.1 3 1 0 3 3 3 2 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI76782.1 - 0.0005 20.1 29.4 0.01 15.9 4.0 4.7 5 0 0 5 5 5 3 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI76782.1 - 0.00097 19.5 10.5 0.00097 19.5 10.5 6.1 4 1 2 6 6 6 2 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI76782.1 - 0.1 12.6 27.5 0.2 11.6 9.0 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI76782.1 - 3.2 8.8 12.2 1.1 10.3 0.3 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI76782.1 - 6.5 6.3 34.5 0.17 11.4 6.8 3.2 3 0 0 3 3 3 0 Spt20 family RCC1 PF00415.18 CDI76785.1 - 1.2e-21 77.1 12.6 1.5e-13 51.2 0.5 3.6 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI76785.1 - 2.9e-10 39.7 16.6 3.7e-05 23.4 3.0 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 CDI76785.1 - 0.03 14.1 0.0 2.5 7.7 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split DUF4602 PF15375.6 CDI76787.1 - 0.018 15.3 4.5 6.5 7.1 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4602) Mac PF12464.8 CDI76787.1 - 0.05 13.8 0.8 0.11 12.8 0.8 1.6 1 0 0 1 1 1 0 Maltose acetyltransferase PID PF00640.23 CDI76787.1 - 0.16 12.0 2.6 0.34 10.9 2.6 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) FUSC PF04632.12 CDI76787.1 - 0.18 10.3 10.9 0.31 9.5 10.9 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family NTP_transf_5 PF14907.6 CDI76787.1 - 0.97 9.0 6.8 1.3 8.6 6.8 1.1 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase DUF3391 PF11871.8 CDI76787.1 - 3.2 8.3 9.7 5.5 7.5 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) SNF2_N PF00176.23 CDI76791.1 - 2.9e-30 105.2 28.1 2.2e-29 102.3 28.1 2.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CDI76791.1 - 4.1e-06 26.7 6.3 4.1e-06 26.7 6.3 3.0 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_2 PF13639.6 CDI76791.1 - 4.4e-06 26.9 8.5 4.4e-06 26.9 8.5 3.8 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_4 PF15227.6 CDI76791.1 - 0.00064 19.8 5.1 0.00064 19.8 5.1 3.7 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CDI76791.1 - 0.0034 17.2 5.6 0.0034 17.2 5.6 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI76791.1 - 0.0035 17.2 6.3 0.0035 17.2 6.3 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DBR1 PF05011.13 CDI76794.1 - 6.6e-08 33.1 0.0 9.8e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain EF1_GNE PF00736.19 CDI76795.1 - 1.7e-31 108.2 3.3 1.7e-31 108.2 3.3 1.8 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain DUF1828 PF08861.10 CDI76795.1 - 0.21 11.9 1.7 5.7 7.3 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF1828 DUF5406 PF17400.2 CDI76795.1 - 0.6 10.5 6.7 0.2 12.1 0.9 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5406) PBP1_TM PF14812.6 CDI76795.1 - 4.5 7.7 10.8 2.1 8.8 3.9 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MCM_bind PF09739.9 CDI76796.1 - 1.9e-06 26.7 1.8 1.9e-06 26.7 1.8 3.4 1 1 2 3 3 3 2 Mini-chromosome maintenance replisome factor SUIM_assoc PF16619.5 CDI76796.1 - 8.8e-05 22.5 41.2 0.087 12.9 2.4 4.0 3 1 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 RPN1_RPN2_N PF17781.1 CDI76796.1 - 0.074 12.5 0.1 0.074 12.5 0.1 2.6 2 1 1 3 3 3 0 RPN1/RPN2 N-terminal domain DUF4484 PF14831.6 CDI76796.1 - 0.11 12.5 13.0 0.24 11.4 13.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4484) DUF2722 PF10846.8 CDI76796.1 - 5 6.0 34.5 0.73 8.7 7.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Sec62 PF03839.16 CDI76796.1 - 5.8 6.4 6.6 20 4.6 4.0 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 NTF2 PF02136.20 CDI76797.1 - 1.9e-30 105.9 0.0 2.2e-30 105.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 CDI76797.1 - 0.0011 18.9 0.0 0.0012 18.8 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 SnoaL_2 PF12680.7 CDI76797.1 - 0.041 14.5 0.0 0.044 14.4 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF4440 PF14534.6 CDI76797.1 - 0.096 13.1 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) NapD PF03927.13 CDI76797.1 - 0.15 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 NapD protein Fumble PF03630.14 CDI76800.1 - 1.4e-57 195.4 0.0 2.9e-40 138.5 0.0 2.3 1 1 1 2 2 2 2 Fumble Pkinase PF00069.25 CDI76801.1 - 2.4e-07 30.4 0.0 0.00013 21.4 0.0 3.7 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76801.1 - 0.013 14.8 4.6 1.2 8.4 0.0 3.0 3 0 0 3 3 3 0 Protein tyrosine kinase Na_trans_assoc PF06512.13 CDI76803.1 - 0.32 11.3 17.8 0.33 11.2 15.4 2.0 2 0 0 2 2 2 0 Sodium ion transport-associated Hid1 PF12722.7 CDI76803.1 - 0.49 8.5 21.9 0.61 8.1 21.9 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V_ATPase_I PF01496.19 CDI76803.1 - 0.84 7.5 19.3 1.1 7.1 19.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI76803.1 - 0.99 8.4 15.4 1.7 7.6 15.4 1.4 1 0 0 1 1 1 0 CLN3 protein PPP4R2 PF09184.11 CDI76803.1 - 5.2 6.6 23.1 0.43 10.1 18.9 1.5 2 0 0 2 2 2 0 PPP4R2 SID-1_RNA_chan PF13965.6 CDI76803.1 - 5.5 5.3 8.7 6.7 5.0 8.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NPR3 PF03666.13 CDI76803.1 - 7.4 5.2 22.4 10 4.8 22.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 WBS_methylT PF12589.8 CDI76804.1 - 1.2e-11 45.2 8.0 1.2e-11 45.2 8.0 2.3 2 0 0 2 2 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CDI76804.1 - 1.3e-05 25.7 0.0 0.0002 22.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI76804.1 - 0.00016 22.3 0.0 0.0016 19.1 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain TPMT PF05724.11 CDI76804.1 - 0.044 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 CDI76804.1 - 0.057 13.2 0.0 0.12 12.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Spt20 PF12090.8 CDI76805.1 - 2.1e-07 30.8 70.0 0.0013 18.4 11.7 4.5 4 0 0 4 4 4 4 Spt20 family RskA PF10099.9 CDI76805.1 - 0.00062 20.1 25.0 0.002 18.4 5.7 5.7 3 2 2 5 5 5 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI76805.1 - 0.0054 16.4 9.4 0.0054 16.4 9.4 6.3 3 2 3 7 7 7 2 Nuclear RNA-splicing-associated protein ParA PF10609.9 CDI76806.1 - 1.1e-77 260.9 0.0 1.8e-77 260.1 0.0 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDI76806.1 - 6.6e-11 42.4 0.0 1.3e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDI76806.1 - 8e-10 38.9 0.1 7.7e-09 35.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 CDI76806.1 - 5.4e-06 26.1 2.4 1.4e-05 24.7 0.0 2.6 2 1 0 2 2 2 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 CDI76806.1 - 2.1e-05 23.8 3.2 0.00011 21.6 0.1 2.8 3 0 0 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 CDI76806.1 - 7.7e-05 22.1 0.0 0.00049 19.5 0.0 2.3 2 1 0 2 2 2 1 ATPase MipZ RsgA_GTPase PF03193.16 CDI76806.1 - 0.00079 19.4 1.1 0.0033 17.4 0.1 2.4 3 0 0 3 3 2 1 RsgA GTPase Spt20 PF12090.8 CDI76806.1 - 0.0028 17.3 10.1 0.0028 17.3 10.1 1.7 2 0 0 2 2 2 1 Spt20 family NB-ARC PF00931.22 CDI76806.1 - 0.0041 16.3 2.2 0.0043 16.3 0.2 1.9 2 0 0 2 2 2 1 NB-ARC domain TFIIA PF03153.13 CDI76806.1 - 0.0071 16.4 6.9 0.0071 16.4 6.9 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit MeaB PF03308.16 CDI76806.1 - 0.0095 14.9 1.0 0.02 13.9 0.0 1.9 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB LapA_dom PF06305.11 CDI76806.1 - 0.01 15.6 0.6 0.019 14.8 0.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain AAA_25 PF13481.6 CDI76806.1 - 0.015 14.8 0.1 0.051 13.2 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_26 PF13500.6 CDI76806.1 - 0.017 15.0 1.3 0.1 12.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF2722 PF10846.8 CDI76806.1 - 0.021 13.8 7.5 0.038 12.9 7.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) APS_kinase PF01583.20 CDI76806.1 - 0.03 14.2 0.0 0.062 13.2 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 CDI76806.1 - 0.041 14.4 0.2 0.12 12.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain EphA2_TM PF14575.6 CDI76806.1 - 0.042 14.7 0.3 0.095 13.6 0.3 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Galanin PF01296.18 CDI76806.1 - 0.048 13.7 0.2 0.13 12.3 0.2 1.8 1 0 0 1 1 1 0 Galanin DUF2489 PF10675.9 CDI76806.1 - 0.078 12.9 6.8 0.19 11.7 6.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) Plasmodium_Vir PF05795.11 CDI76806.1 - 0.08 12.4 0.2 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TsaE PF02367.17 CDI76806.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KTI12 PF08433.10 CDI76806.1 - 0.22 10.9 1.7 0.44 9.9 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 CDI76806.1 - 0.23 11.4 0.6 0.54 10.2 0.2 1.8 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.6 CDI76806.1 - 0.41 10.3 0.1 0.41 10.3 0.1 1.9 2 0 0 2 2 2 0 AAA domain Herpes_DNAp_acc PF04929.12 CDI76806.1 - 0.57 9.1 3.3 0.95 8.4 3.3 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CcmD PF04995.14 CDI76806.1 - 1.4 9.0 4.2 4.4 7.5 4.2 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF4834 PF16118.5 CDI76806.1 - 1.5 9.8 4.2 0.6 11.1 0.8 2.1 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) DUF2681 PF10883.8 CDI76806.1 - 1.8 9.0 14.9 0.82 10.1 8.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) COG4 PF08318.12 CDI76807.1 - 3e-10 39.7 0.5 3e-10 39.7 0.5 4.3 3 1 2 5 5 5 2 COG4 transport protein SPX PF03105.19 CDI76807.1 - 2.5e-06 27.7 5.7 2.5e-06 27.7 5.7 3.3 1 1 0 3 3 3 1 SPX domain DciA PF05258.12 CDI76807.1 - 6.6 7.2 14.2 0.091 13.2 1.1 4.3 3 1 0 3 3 3 0 Dna[CI] antecedent, DciA TSP_1 PF00090.19 CDI76808.1 - 9.3e-08 32.2 6.8 9.3e-08 32.2 6.8 5.1 5 0 0 5 5 5 3 Thrombospondin type 1 domain DUF4527 PF15030.6 CDI76810.1 - 0.0085 15.6 0.1 0.0088 15.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4527) Form_Nir_trans PF01226.17 CDI76813.1 - 2e-44 151.7 8.6 2.8e-44 151.3 8.6 1.2 1 0 0 1 1 1 1 Formate/nitrite transporter LANC_like PF05147.13 CDI76815.1 - 2.3e-25 88.9 0.6 1.4e-11 43.6 0.0 4.0 4 0 0 4 4 4 3 Lanthionine synthetase C-like protein PknG_rubred PF16919.5 CDI76816.1 - 0.055 13.6 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain EF-hand_9 PF14658.6 CDI76816.1 - 0.11 12.8 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain GRIN_C PF15235.6 CDI76817.1 - 0.19 11.9 7.7 0.34 11.1 7.7 1.5 1 0 0 1 1 1 0 G protein-regulated inducer of neurite outgrowth C-terminus LepA_C PF06421.12 CDI76818.1 - 0.039 14.1 1.2 0.052 13.7 1.2 1.3 1 1 0 1 1 1 0 GTP-binding protein LepA C-terminus DUF4728 PF15860.5 CDI76819.1 - 0.037 14.7 5.5 0.19 12.4 2.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) SHMT PF00464.19 CDI76820.1 - 2.4e-165 550.0 0.0 3e-165 549.7 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 CDI76820.1 - 0.013 14.9 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family PI3_PI4_kinase PF00454.27 CDI76821.1 - 8.3e-33 114.2 0.0 1.3e-32 113.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Phage_head_fibr PF11133.8 CDI76822.1 - 0.11 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Head fiber protein RPN1_RPN2_N PF17781.1 CDI76823.1 - 6.4e-114 380.5 0.3 1e-113 379.8 0.3 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CDI76823.1 - 8.5e-27 93.0 0.1 1.7e-26 92.0 0.1 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CDI76823.1 - 4.9e-12 45.6 37.0 0.00027 21.2 0.2 8.7 9 0 0 9 9 9 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CDI76823.1 - 0.13 12.7 0.1 0.13 12.7 0.1 4.4 4 1 0 4 4 4 0 HEAT repeats Mucin PF01456.17 CDI76823.1 - 9.3 6.2 19.4 0.24 11.4 1.7 2.8 3 0 0 3 3 3 0 Mucin-like glycoprotein ThiF PF00899.21 CDI76824.1 - 1e-49 169.1 0.0 6.3e-48 163.3 0.0 2.2 2 0 0 2 2 2 1 ThiF family UBA_e1_thiolCys PF10585.9 CDI76824.1 - 1.1e-48 166.4 6.2 1.1e-48 166.4 6.2 3.5 3 1 0 3 3 3 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 CDI76824.1 - 6.1e-19 68.0 0.1 1.2e-18 67.0 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 CDI76824.1 - 3e-08 33.7 1.1 1.4e-07 31.6 1.1 2.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle DUF2722 PF10846.8 CDI76824.1 - 0.00024 20.2 1.8 0.00024 20.2 1.8 4.1 4 1 0 4 4 3 1 Protein of unknown function (DUF2722) DUF1840 PF08895.11 CDI76824.1 - 0.031 14.6 1.1 0.031 14.6 1.1 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) DUF3439 PF11921.8 CDI76824.1 - 0.072 13.1 4.0 0.25 11.3 4.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) EBP50_C PF09007.11 CDI76824.1 - 0.08 13.9 21.3 6.6 7.7 6.6 4.4 4 0 0 4 4 4 0 EBP50, C-terminal Suf PF05843.14 CDI76824.1 - 0.24 11.4 19.9 0.9 9.5 0.6 3.9 4 0 0 4 4 4 0 Suppressor of forked protein (Suf) Methyltransf_12 PF08242.12 CDI76824.1 - 0.83 10.4 3.1 19 6.1 0.1 2.8 2 0 0 2 2 2 0 Methyltransferase domain SURF1 PF02104.15 CDI76824.1 - 1.8 8.8 6.0 0.66 10.2 0.7 2.8 3 0 0 3 3 3 0 SURF1 family Presenilin PF01080.17 CDI76824.1 - 8.6 5.0 31.8 0.0045 15.8 7.2 2.7 2 1 0 2 2 1 0 Presenilin IMUP PF15761.5 CDI76824.1 - 8.8 7.1 17.1 25 5.6 9.0 2.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein PSCyt3 PF07627.11 CDI76824.1 - 8.8 6.7 7.0 4.1 7.7 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) WRNPLPNID PF15017.6 CDI76824.1 - 9 7.3 34.3 1.5 9.8 11.3 4.2 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box Guanylate_cyc PF00211.20 CDI76825.1 - 9e-37 126.5 0.0 1.5e-36 125.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Shisa PF13908.6 CDI76830.1 - 0.042 14.1 0.6 0.067 13.4 0.6 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Orf78 PF06024.12 CDI76830.1 - 0.21 11.9 0.0 0.39 11.1 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF4551 PF15087.6 CDI76832.1 - 0.49 9.2 32.3 0.53 9.1 32.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF2722 PF10846.8 CDI76833.1 - 6.9e-05 22.0 6.4 6.9e-05 22.0 6.4 7.1 5 2 1 6 6 6 1 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI76833.1 - 0.00043 20.7 37.7 0.36 11.2 3.3 6.9 7 1 0 7 7 7 2 Enhancer of polycomb-like Spt20 PF12090.8 CDI76833.1 - 0.00077 19.1 8.7 0.00077 19.1 8.7 7.9 7 1 0 7 7 7 1 Spt20 family TMEM51 PF15345.6 CDI76833.1 - 0.0025 17.7 0.3 0.0025 17.7 0.3 6.5 7 1 0 7 7 7 2 Transmembrane protein 51 SprA-related PF12118.8 CDI76833.1 - 0.0041 16.3 6.9 0.0041 16.3 6.9 7.9 8 2 1 9 9 9 1 SprA-related family Plasmodium_Vir PF05795.11 CDI76833.1 - 0.083 12.3 0.1 0.083 12.3 0.1 3.7 3 1 0 3 3 3 0 Plasmodium vivax Vir protein N6_N4_Mtase PF01555.18 CDI76833.1 - 0.2 11.4 0.0 47 3.6 0.0 3.7 3 2 0 3 3 3 0 DNA methylase DcuA_DcuB PF03605.14 CDI76833.1 - 0.26 10.2 0.0 0.26 10.2 0.0 4.1 5 0 0 5 5 5 0 Anaerobic c4-dicarboxylate membrane transporter OATP PF03137.20 CDI76833.1 - 4.3 5.5 22.8 0.36 9.1 0.0 4.4 5 0 0 5 5 5 0 Organic Anion Transporter Polypeptide (OATP) family FAM176 PF14851.6 CDI76833.1 - 9 5.9 32.8 2.8 7.6 1.1 6.2 6 0 0 6 6 6 0 FAM176 family DUF2729 PF10870.8 CDI76834.1 - 1e-07 31.7 0.2 0.019 14.8 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2729) Peroxin-3 PF04882.12 CDI76834.1 - 0.0045 16.0 1.9 0.0045 16.0 1.9 2.0 2 0 0 2 2 2 1 Peroxin-3 Methyltranf_PUA PF13636.6 CDI76834.1 - 0.032 14.2 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 RNA-binding PUA-like domain of methyltransferase RsmF zf-RING_2 PF13639.6 CDI76834.1 - 0.13 12.6 13.6 2.5 8.5 2.9 3.1 2 2 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 CDI76834.1 - 0.17 11.8 10.7 5.7 6.9 1.3 3.9 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SPX PF03105.19 CDI76834.1 - 0.18 11.7 13.4 0.26 11.1 13.4 1.3 1 0 0 1 1 1 0 SPX domain REC114-like PF15165.6 CDI76834.1 - 0.26 11.0 11.1 1.5 8.5 3.8 2.4 2 1 0 3 3 3 0 Meiotic recombination protein REC114-like DUF4171 PF13775.6 CDI76834.1 - 0.48 10.9 33.8 0.3 11.5 12.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) Presenilin PF01080.17 CDI76834.1 - 1.1 8.0 6.7 1.3 7.8 6.7 1.2 1 0 0 1 1 1 0 Presenilin EBP50_C PF09007.11 CDI76834.1 - 7.6 7.5 14.3 3.1 8.8 3.1 2.3 2 0 0 2 2 2 0 EBP50, C-terminal DUF1980 PF09323.10 CDI76834.1 - 7.6 6.4 5.8 0.95 9.4 0.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) zf-C3HC4_2 PF13923.6 CDI76834.1 - 9.8 6.1 17.6 53 3.8 5.0 4.0 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-met PF12874.7 CDI76835.1 - 2.3e-08 34.1 3.5 3e-05 24.3 0.7 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 CDI76835.1 - 5.1e-08 32.9 3.7 0.0035 17.7 0.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CDI76835.1 - 1.3e-07 31.7 4.1 3.6e-06 27.1 1.5 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CDI76835.1 - 1.4e-07 31.8 4.1 0.0072 17.1 0.2 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDI76835.1 - 2.9e-06 27.1 5.1 0.0025 17.8 0.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CDI76835.1 - 6e-06 26.5 14.5 0.0069 16.7 1.1 3.8 3 1 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-MYST PF17772.1 CDI76835.1 - 0.012 15.2 0.2 0.027 14.1 0.2 1.6 1 0 0 1 1 1 0 MYST family zinc finger domain zf-DBF PF07535.12 CDI76835.1 - 0.38 10.9 4.1 0.42 10.8 1.5 2.2 2 0 0 2 2 2 0 DBF zinc finger Kinesin PF00225.23 CDI76836.1 - 1.9e-65 221.0 0.0 7.1e-41 140.2 0.0 2.6 2 1 0 2 2 2 2 Kinesin motor domain Solute_trans_a PF03619.16 CDI76836.1 - 6.3e-28 98.0 10.3 4.9e-14 52.5 0.4 3.2 3 0 0 3 3 3 3 Organic solute transporter Ostalpha Microtub_bd PF16796.5 CDI76836.1 - 7.6e-12 45.4 0.0 2.6e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 Microtubule binding SUIM_assoc PF16619.5 CDI76836.1 - 0.23 11.6 20.6 0.71 10.0 5.0 3.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Aha1_N PF09229.11 CDI76839.1 - 4.4e-13 49.6 0.0 1.2e-12 48.2 0.0 1.8 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal TPR_2 PF07719.17 CDI76839.1 - 1.2e-09 37.6 2.2 0.092 12.9 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDI76839.1 - 1.4e-08 34.2 1.9 0.036 13.9 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDI76839.1 - 4.5e-06 26.2 9.8 0.015 14.9 0.8 4.3 3 1 1 4 4 4 2 TPR repeat TPR_9 PF13371.6 CDI76839.1 - 9.9e-06 25.6 1.2 2.4e-05 24.4 0.5 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI76839.1 - 0.00054 20.6 5.9 0.3 12.0 0.7 4.1 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDI76839.1 - 0.00059 20.3 6.7 0.00092 19.7 2.6 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI76839.1 - 0.0011 19.5 8.4 0.0065 17.1 1.5 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDI76839.1 - 0.0016 18.9 4.1 1.8 9.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI76839.1 - 0.002 18.2 1.1 1.7 8.7 0.0 3.2 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 CDI76839.1 - 0.0059 16.7 1.7 0.098 12.7 0.1 3.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 CDI76839.1 - 0.057 13.7 2.7 11 6.4 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 CDI76839.1 - 0.11 12.8 6.8 0.07 13.5 3.5 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI76839.1 - 0.24 11.7 3.0 1.3 9.3 1.8 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4530 PF15039.6 CDI76839.1 - 0.24 11.5 4.0 0.28 11.3 2.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4530) TPR_8 PF13181.6 CDI76839.1 - 0.38 11.1 2.1 2.4 8.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF755 PF05501.11 CDI76839.1 - 1.5 9.1 12.2 3.6 7.9 12.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) MPM1 PF17234.2 CDI76839.1 - 5.9 7.1 8.4 12 6.1 8.4 1.5 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SR-25 PF10500.9 CDI76839.1 - 7.1 6.2 20.3 5.9 6.4 18.2 1.8 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Trehalose_PPase PF02358.16 CDI76840.1 - 1.2e-27 96.6 0.0 1.6e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Trehalose-phosphatase AAA_8 PF12780.7 CDI76842.1 - 5.6e-87 291.4 0.0 1.4e-86 290.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.7 CDI76842.1 - 1.6e-59 201.7 18.1 6.2e-59 199.7 17.5 1.9 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_lid_1 PF17857.1 CDI76842.1 - 1.3e-25 89.5 0.2 2.8e-25 88.4 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_7 PF12775.7 CDI76842.1 - 2.4e-23 82.6 0.1 1.8e-22 79.8 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region SKA2 PF16740.5 CDI76842.1 - 0.002 17.9 1.7 0.002 17.9 1.7 3.0 2 1 1 3 3 3 1 Spindle and kinetochore-associated protein 2 DUF4446 PF14584.6 CDI76842.1 - 0.032 14.2 0.9 0.032 14.2 0.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) INCA1 PF15142.6 CDI76842.1 - 0.21 11.6 1.1 0.46 10.5 1.1 1.5 1 0 0 1 1 1 0 INCA1 DUF573 PF04504.14 CDI76842.1 - 0.28 11.9 2.1 0.42 11.3 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function, DUF573 EspB PF05802.11 CDI76842.1 - 0.72 9.8 11.8 0.51 10.3 0.2 2.4 2 0 0 2 2 2 0 Enterobacterial EspB protein Muted PF14942.6 CDI76842.1 - 0.88 9.9 21.7 0.56 10.5 6.2 2.7 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein NPV_P10 PF05531.12 CDI76842.1 - 1.2 9.7 7.0 0.34 11.4 0.4 3.4 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 CDI76842.1 - 1.2 9.4 11.1 2.1 8.6 0.9 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 CDI76842.1 - 1.3 9.2 12.9 1 9.5 2.7 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Noelin-1 PF12308.8 CDI76842.1 - 1.3 9.0 3.8 1.5 8.9 0.8 2.6 2 0 0 2 2 2 0 Neurogenesis glycoprotein DUF4407 PF14362.6 CDI76842.1 - 2 7.7 19.8 2.8 7.2 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CHASE3 PF05227.13 CDI76842.1 - 2.3 8.1 18.3 0.53 10.2 10.1 2.6 2 0 0 2 2 2 0 CHASE3 domain FapA PF03961.13 CDI76842.1 - 3.3 6.2 11.1 1.2 7.7 1.2 2.9 3 0 0 3 3 3 0 Flagellar Assembly Protein A ISG65-75 PF11727.8 CDI76842.1 - 4 6.6 24.3 0.65 9.2 12.0 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein Phage_GP20 PF06810.11 CDI76842.1 - 4.3 7.1 23.3 4.1 7.2 3.7 2.8 2 1 0 2 2 2 0 Phage minor structural protein GP20 Cep57_CLD_2 PF14197.6 CDI76842.1 - 4.3 7.5 10.5 0.28 11.3 1.1 3.1 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Occludin_ELL PF07303.13 CDI76842.1 - 4.6 8.0 7.0 4.7 8.0 0.3 3.8 3 1 1 4 4 3 0 Occludin homology domain PK PF00224.21 CDI76844.1 - 4.7e-71 239.5 0.0 6.1e-32 110.9 0.2 3.2 3 0 0 3 3 3 3 Pyruvate kinase, barrel domain PK_C PF02887.16 CDI76844.1 - 2.3e-12 47.2 0.7 4.8e-11 42.9 0.0 3.1 2 1 0 2 2 2 1 Pyruvate kinase, alpha/beta domain DUF2722 PF10846.8 CDI76844.1 - 0.0012 17.9 13.8 0.0099 14.9 2.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Androgen_recep PF02166.16 CDI76844.1 - 0.0018 17.2 3.6 0.0018 17.2 3.6 3.7 4 0 0 4 4 2 2 Androgen receptor RskA PF10099.9 CDI76844.1 - 0.031 14.6 0.7 0.031 14.6 0.7 4.1 3 2 0 3 3 2 0 Anti-sigma-K factor rskA EPL1 PF10513.9 CDI76844.1 - 0.19 12.1 5.0 7.2 7.0 0.9 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like Suf PF05843.14 CDI76844.1 - 1.4 8.8 6.7 7.9 6.4 0.6 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CDI76844.1 - 1.6 8.3 33.3 0.21 11.1 11.6 2.2 2 0 0 2 2 2 0 Spt20 family DUF3371 PF11851.8 CDI76844.1 - 1.7 9.7 11.7 11 7.2 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) Spore_III_AF PF09581.10 CDI76844.1 - 3.6 7.6 9.2 3.6 7.6 3.4 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) SARAF PF06682.12 CDI76844.1 - 4.2 6.9 6.5 2.9 7.5 1.5 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis eIF_4EBP PF05456.11 CDI76844.1 - 9.5 6.2 9.6 9.8 6.2 1.3 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) PCRF PF03462.18 CDI76846.1 - 3.3e-31 108.7 11.5 3.3e-31 108.7 11.5 3.3 2 2 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CDI76846.1 - 1.4e-29 102.4 2.3 1.4e-29 102.4 2.3 5.0 5 1 0 6 6 6 1 RF-1 domain EOS1 PF12326.8 CDI76846.1 - 0.84 9.5 0.0 0.84 9.5 0.0 2.7 2 1 0 2 2 2 0 N-glycosylation protein Aldedh PF00171.22 CDI76847.1 - 0.00031 19.4 5.8 0.0014 17.2 0.0 2.9 3 0 0 3 3 3 3 Aldehyde dehydrogenase family zf-CCCH PF00642.24 CDI76848.1 - 2.5e-08 33.6 21.1 2.1e-06 27.5 2.9 3.8 3 1 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDI76848.1 - 2.4e-07 30.4 2.5 2.4e-07 30.4 2.5 3.8 4 1 0 4 4 4 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CDI76848.1 - 1.4e-05 24.9 4.4 1.4e-05 24.9 4.4 4.7 5 0 0 5 5 5 1 Zinc finger domain zf-C3H1 PF10650.9 CDI76848.1 - 0.00039 20.1 8.5 0.84 9.4 0.5 3.6 3 0 0 3 3 3 3 Putative zinc-finger domain zf-CCCH_2 PF14608.6 CDI76848.1 - 0.0024 18.3 17.0 0.098 13.2 2.4 3.8 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CDI76848.1 - 0.031 15.0 12.3 0.06 14.1 2.7 2.8 1 1 2 3 3 3 0 Torus domain zf-CCCH_3 PF15663.5 CDI76848.1 - 0.25 11.6 7.0 1.5 9.1 3.7 2.4 2 0 0 2 2 2 0 Zinc-finger containing family Spt20 PF12090.8 CDI76849.1 - 0.0031 17.2 2.3 0.0031 17.2 2.3 9.4 4 3 2 6 6 6 1 Spt20 family SR-25 PF10500.9 CDI76851.1 - 0.0024 17.5 10.2 0.0024 17.5 10.2 4.3 2 1 2 4 4 4 1 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI76853.1 - 0.0064 16.5 2.9 0.0064 16.5 2.9 8.5 10 0 0 10 10 10 5 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI76853.1 - 0.012 15.2 2.6 0.012 15.2 2.6 6.3 5 1 0 5 5 5 0 Spt20 family RskA PF10099.9 CDI76854.1 - 0.0015 18.8 7.6 0.0015 18.8 7.6 9.3 1 1 5 6 6 6 3 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI76854.1 - 0.0025 17.5 11.7 0.0025 17.5 11.7 7.5 3 2 4 7 7 7 1 Nuclear RNA-splicing-associated protein GRA6 PF05084.13 CDI76854.1 - 0.0033 17.4 4.2 0.0033 17.4 4.2 5.1 3 1 3 6 6 6 1 Granule antigen protein (GRA6) SUIM_assoc PF16619.5 CDI76855.1 - 0.0013 18.8 0.8 0.0013 18.8 0.8 5.7 1 1 4 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 DUF2339 PF10101.9 CDI76855.1 - 0.054 12.1 9.9 0.062 11.9 9.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) GREB1 PF15782.5 CDI76855.1 - 1.8 5.6 30.2 2.1 5.3 30.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDK5_activator PF03261.15 CDI76855.1 - 5.1 6.5 18.4 6.8 6.1 18.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF5523 PF17661.1 CDI76855.1 - 8 6.1 36.3 1.7 8.3 29.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) LAP1C PF05609.12 CDI76856.1 - 0.044 12.9 27.2 0.056 12.5 27.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SOG2 PF10428.9 CDI76856.1 - 0.1 11.8 38.0 0.14 11.3 38.0 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 CDI76856.1 - 0.11 11.2 30.2 0.12 11.1 30.2 1.1 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI76856.1 - 0.78 6.8 34.0 0.94 6.5 34.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S64 PF08192.11 CDI76856.1 - 2.2 6.7 35.4 2.9 6.3 35.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 SRP-alpha_N PF04086.13 CDI76856.1 - 2.2 8.1 33.7 3.6 7.4 33.7 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 CDI76856.1 - 3.3 7.5 22.3 5 6.9 22.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI76856.1 - 6.3 4.9 22.2 8.4 4.5 22.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF966 PF06136.13 CDI76857.1 - 1.9 8.1 34.8 2.8 7.6 34.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) LAP1C PF05609.12 CDI76857.1 - 2 7.4 43.9 2.4 7.1 43.9 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ribosomal_60s PF00428.19 CDI76857.1 - 2.2 8.9 10.4 1 10.0 7.7 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Acyl_transf_3 PF01757.22 CDI76858.1 - 0.38 9.7 11.8 0.15 11.1 8.7 1.8 2 0 0 2 2 2 0 Acyltransferase family NAP PF00956.18 CDI76859.1 - 1.3e-06 27.8 0.2 1.3e-06 27.8 0.2 6.1 2 1 0 2 2 2 1 Nucleosome assembly protein (NAP) RXLR PF16810.5 CDI76859.1 - 0.0013 19.2 3.6 0.0013 19.2 3.6 6.2 2 1 0 2 2 2 1 RXLR phytopathogen effector protein, Avirulence activity FAM60A PF15396.6 CDI76861.1 - 4.8 7.1 33.4 5.3 7.0 33.4 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF4746 PF15928.5 CDI76861.1 - 5.9 6.2 27.9 7.4 5.9 27.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI76861.1 - 8.8 5.0 46.3 9.6 4.9 46.3 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CDI76861.1 - 9.1 4.9 37.5 9.8 4.8 37.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3729 PF12526.8 CDI76861.1 - 9.6 7.8 12.2 17 7.0 12.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3729) RskA PF10099.9 CDI76862.1 - 4.3e-05 23.9 23.3 4.3e-05 23.9 23.3 2.4 2 1 1 3 3 3 1 Anti-sigma-K factor rskA EIF4E-T PF10477.9 CDI76862.1 - 0.0055 15.6 6.6 0.006 15.5 6.6 1.0 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF2722 PF10846.8 CDI76862.1 - 0.011 14.7 6.3 0.014 14.3 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI76862.1 - 0.011 15.8 19.1 0.012 15.6 19.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Astro_capsid_N PF03115.14 CDI76862.1 - 0.042 12.5 3.4 0.069 11.8 3.4 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DDE_1 PF03184.19 CDI76862.1 - 0.09 12.4 0.8 0.14 11.8 0.8 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease PSI_PsaF PF02507.15 CDI76862.1 - 0.11 12.4 3.5 0.21 11.4 3.5 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Calc_CGRP_IAPP PF00214.19 CDI76862.1 - 1.3 9.4 4.7 3.1 8.2 4.7 1.6 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family DUF4179 PF13786.6 CDI76862.1 - 7.5 7.1 8.3 0.56 10.7 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Macoilin PF09726.9 CDI76864.1 - 3.6e-08 32.5 29.0 3.6e-08 32.5 29.0 2.4 2 1 0 2 2 2 1 Macoilin family Ribosomal_S10 PF00338.22 CDI76864.1 - 1.4e-06 28.4 0.6 1.4e-06 28.4 0.6 2.5 3 1 0 3 3 3 1 Ribosomal protein S10p/S20e SOBP PF15279.6 CDI76864.1 - 0.32 11.6 60.3 1.5 9.3 22.9 3.3 3 0 0 3 3 3 0 Sine oculis-binding protein Utp14 PF04615.13 CDI76864.1 - 0.61 8.6 43.7 0.1 11.1 29.0 2.1 2 0 0 2 2 2 0 Utp14 protein RNA_pol_Rpc4 PF05132.14 CDI76866.1 - 8.4e-08 32.8 0.0 8.4e-08 32.8 0.0 6.9 4 2 0 4 4 4 1 RNA polymerase III RPC4 Utp14 PF04615.13 CDI76866.1 - 2.8 6.4 45.9 1.1 7.8 43.4 1.5 1 1 0 1 1 1 0 Utp14 protein NPL4 PF05021.15 CDI76868.1 - 3.7e-11 42.9 0.0 9.4e-10 38.3 0.0 2.7 1 1 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 CDI76868.1 - 2.7e-05 24.3 0.0 6.5e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Macoilin PF09726.9 CDI76868.1 - 2.3 6.6 7.2 4.5 5.7 7.2 1.5 1 0 0 1 1 1 0 Macoilin family C_GCAxxG_C_C PF09719.10 CDI76869.1 - 0.15 12.3 3.6 0.18 12.1 3.6 1.1 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) CD20 PF04103.15 CDI76869.1 - 0.37 10.9 0.9 0.49 10.5 0.9 1.3 1 0 0 1 1 1 0 CD20-like family DUF4820 PF16091.5 CDI76869.1 - 0.45 9.8 16.0 0.56 9.5 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) FHIPEP PF00771.20 CDI76869.1 - 0.54 8.7 12.7 0.68 8.3 12.7 1.3 1 0 0 1 1 1 0 FHIPEP family SID-1_RNA_chan PF13965.6 CDI76869.1 - 1.4 7.3 10.5 1.4 7.2 10.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ureide_permease PF07168.11 CDI76869.1 - 1.6 7.4 11.6 1.7 7.3 11.6 1.0 1 0 0 1 1 1 0 Ureide permease Connexin PF00029.19 CDI76869.1 - 1.8 8.3 17.0 1.8 8.2 17.0 1.0 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 CDI76869.1 - 1.8 8.2 14.3 2 8.1 14.3 1.1 1 0 0 1 1 1 0 FAM176 family R_equi_Vir PF05526.11 CDI76869.1 - 1.9 8.3 14.9 2.2 8.1 14.9 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein BAF1_ABF1 PF04684.13 CDI76869.1 - 2.7 7.0 23.4 3 6.8 23.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RPN2_C PF18004.1 CDI76869.1 - 3.1 7.7 23.1 3.3 7.6 23.1 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SelP_N PF04592.14 CDI76869.1 - 3.9 6.8 21.0 4 6.8 21.0 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AIF_C PF14721.6 CDI76869.1 - 4.8 7.5 18.5 5.7 7.3 18.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DcuA_DcuB PF03605.14 CDI76869.1 - 4.9 5.9 9.1 5.7 5.7 9.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter HemX PF04375.14 CDI76869.1 - 5.1 6.3 37.5 5.4 6.2 37.5 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase G0-G1_switch_2 PF15103.6 CDI76869.1 - 5.1 7.6 16.0 6.6 7.2 16.0 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 OATP PF03137.20 CDI76869.1 - 5.3 5.2 12.4 5.6 5.1 12.4 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SspB PF04386.13 CDI76869.1 - 6.7 6.6 19.9 7.1 6.5 19.9 1.0 1 0 0 1 1 1 0 Stringent starvation protein B Trp_oprn_chp PF09534.10 CDI76869.1 - 6.8 6.4 12.7 12 5.6 12.7 1.6 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SpoIIP PF07454.11 CDI76869.1 - 6.9 6.0 25.2 7.3 6.0 25.2 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Serinc PF03348.15 CDI76869.1 - 6.9 5.5 15.9 7.2 5.4 15.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) O-antigen_lig PF13425.6 CDI76869.1 - 7.1 5.3 11.7 7.4 5.2 11.7 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein YABBY PF04690.13 CDI76869.1 - 7.4 7.1 17.0 7.3 7.1 17.0 1.1 1 0 0 1 1 1 0 YABBY protein CDC45 PF02724.14 CDI76869.1 - 8.2 4.6 17.7 8.2 4.6 17.7 1.0 1 0 0 1 1 1 0 CDC45-like protein NEMP PF10225.9 CDI76869.1 - 8.6 6.0 8.6 9.1 5.9 8.6 1.0 1 0 0 1 1 1 0 NEMP family Paf1 PF03985.13 CDI76869.1 - 10 5.0 27.3 11 4.9 27.3 1.0 1 0 0 1 1 1 0 Paf1 KR PF08659.10 CDI76870.1 - 1.6e-51 174.8 0.0 1.8e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CDI76870.1 - 5.6e-09 35.9 0.0 7.2e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDI76870.1 - 6.6e-09 35.5 0.0 8.9e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CDI76870.1 - 0.07 12.6 0.0 0.081 12.4 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CDI76871.1 - 2.4e-54 184.2 0.0 4e-54 183.5 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Sulfotransfer_3 PF13469.6 CDI76871.1 - 2.1e-43 149.2 0.1 5.1e-43 148.0 0.1 1.7 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 CDI76871.1 - 3.3e-17 62.8 0.2 7.4e-17 61.7 0.2 1.6 1 1 0 1 1 1 1 Sulfotransferase domain PP-binding PF00550.25 CDI76871.1 - 1.4e-11 44.6 0.0 4.8e-11 42.8 0.0 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 CDI76871.1 - 3.9e-08 33.1 0.0 6.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sulfotransfer_4 PF17784.1 CDI76871.1 - 0.00023 21.1 0.3 0.0057 16.5 0.1 3.0 3 0 0 3 3 3 1 Sulfotransferase domain DUF1331 PF07048.11 CDI76871.1 - 0.11 12.2 0.2 0.79 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1331) IMCp PF12314.8 CDI76872.1 - 5e-26 90.8 62.0 9.5e-26 89.9 40.8 5.7 3 2 2 5 5 5 2 Inner membrane complex protein IMCp PF12314.8 CDI76873.1 - 8.9e-31 106.1 92.0 6.5e-19 68.0 39.2 4.3 1 1 2 3 3 3 3 Inner membrane complex protein LSM PF01423.22 CDI76874.1 - 4.3e-15 55.2 0.8 7.6e-15 54.4 0.8 1.4 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDI76874.1 - 0.081 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 Hfq protein AT_hook PF02178.19 CDI76876.1 - 1.3 9.2 5.1 3.2 7.9 5.1 1.7 1 0 0 1 1 1 0 AT hook motif Nucleoside_tran PF01733.18 CDI76877.1 - 1.6e-07 31.0 2.6 2.3e-07 30.5 2.6 1.1 1 0 0 1 1 1 1 Nucleoside transporter EMP24_GP25L PF01105.24 CDI76877.1 - 0.3 11.0 2.0 0.64 9.9 2.0 1.5 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Dynactin_p22 PF07426.11 CDI76880.1 - 0.014 15.3 0.8 0.019 14.8 0.8 1.2 1 0 0 1 1 1 0 Dynactin subunit p22 LRR_2 PF07723.13 CDI76880.1 - 0.33 11.7 1.7 45 4.9 0.1 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat zf-CCCH PF00642.24 CDI76882.1 - 0.005 16.7 0.6 0.005 16.7 0.6 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI76882.1 - 0.29 11.3 3.0 0.11 12.6 0.3 1.8 2 0 0 2 2 2 0 Zinc finger domain TFIIA PF03153.13 CDI76885.1 - 0.0051 16.9 27.8 0.0051 16.9 27.8 6.1 3 1 2 5 5 5 1 Transcription factor IIA, alpha/beta subunit CAP PF00188.26 CDI76888.1 - 0.0012 19.7 0.1 0.0018 19.1 0.1 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Calc_CGRP_IAPP PF00214.19 CDI76888.1 - 0.044 14.1 0.2 0.13 12.6 0.2 2.0 1 1 0 1 1 1 0 Calcitonin / CGRP / IAPP family Surface_antigen PF11054.8 CDI76889.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen DUF3527 PF12043.8 CDI76891.1 - 2.4 7.6 10.5 4.3 6.8 10.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) GREB1 PF15782.5 CDI76891.1 - 7.8 3.5 18.8 11 3.0 18.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Prok-RING_1 PF14446.6 CDI76892.1 - 0.0023 17.8 5.6 0.0023 17.8 5.6 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 SPX PF03105.19 CDI76892.1 - 0.68 9.8 15.8 1.3 8.9 5.3 2.8 2 1 0 2 2 2 0 SPX domain Syja_N PF02383.18 CDI76893.1 - 3.1e-44 151.6 0.1 3.4e-41 141.6 0.0 3.7 3 1 0 3 3 3 2 SacI homology domain PIP5K PF01504.18 CDI76893.1 - 2.5 7.3 5.4 5.9 6.0 0.6 2.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase PX PF00787.24 CDI76895.1 - 5.2e-15 55.4 0.0 1.5e-14 53.9 0.0 1.8 1 0 0 1 1 1 1 PX domain RskA PF10099.9 CDI76895.1 - 0.0031 17.8 25.5 0.0031 17.8 25.5 8.2 2 2 4 6 6 6 2 Anti-sigma-K factor rskA Ras PF00071.22 CDI76896.1 - 1.1e-09 38.2 0.0 1.3e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CDI76896.1 - 1.1e-07 32.1 0.0 0.0057 16.9 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CDI76896.1 - 0.015 14.8 0.0 0.039 13.5 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDI76896.1 - 0.028 14.5 0.0 0.12 12.5 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 CDI76896.1 - 0.06 13.5 0.0 0.26 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Methyltransf_25 PF13649.6 CDI76897.1 - 9.9e-06 26.2 0.0 1.9e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI76897.1 - 0.0025 17.6 0.0 0.0034 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI76897.1 - 0.015 16.0 0.0 0.024 15.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDI76897.1 - 0.065 13.9 0.0 0.095 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDI76897.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Macoilin PF09726.9 CDI76898.1 - 3.5e-06 25.9 11.7 4.6e-06 25.5 11.7 1.1 1 0 0 1 1 1 1 Macoilin family SR-25 PF10500.9 CDI76898.1 - 0.096 12.3 51.0 0.15 11.7 28.3 2.5 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Ndc1_Nup PF09531.10 CDI76898.1 - 1.1 7.9 13.2 1.6 7.3 13.2 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 CDI76898.1 - 1.6 6.9 13.7 3.1 6.0 13.7 1.5 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 CDI76899.1 - 3.2e-30 105.4 0.0 1.7e-16 60.4 0.0 4.0 3 2 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI76899.1 - 2.1e-09 37.1 0.0 0.0036 16.6 0.0 3.7 3 0 0 3 3 3 3 Protein tyrosine kinase Pox_Ag35 PF03286.14 CDI76899.1 - 1.8 8.3 8.0 4 7.2 8.0 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein ThiF PF00899.21 CDI76900.1 - 1.8e-06 27.5 0.2 1e-05 25.0 0.2 2.2 1 1 0 1 1 1 1 ThiF family PAT1 PF09770.9 CDI76900.1 - 0.002 16.5 33.9 0.0032 15.8 33.9 1.5 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.10 CDI76900.1 - 0.0027 16.5 44.8 0.0045 15.8 44.8 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4667 PF15700.5 CDI76900.1 - 0.014 15.5 0.2 0.014 15.5 0.2 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4667) DASH_Spc19 PF08287.11 CDI76900.1 - 0.22 11.4 0.0 0.22 11.4 0.0 3.9 3 2 0 3 3 3 0 Spc19 Exonuc_VII_L PF02601.15 CDI76900.1 - 0.41 10.2 26.8 0.86 9.1 21.9 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF5523 PF17661.1 CDI76900.1 - 0.77 9.4 34.5 0.028 14.1 27.6 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Presenilin PF01080.17 CDI76900.1 - 2.1 7.0 46.8 0.078 11.7 31.7 3.0 3 0 0 3 3 3 0 Presenilin FAM60A PF15396.6 CDI76900.1 - 3.2 7.7 34.1 0.45 10.5 19.6 3.2 3 0 0 3 3 3 0 Protein Family FAM60A Cullin_binding PF03556.15 CDI76901.1 - 3e-22 79.3 0.5 1.4e-14 54.5 0.1 2.4 2 0 0 2 2 2 2 Cullin binding UBA_4 PF14555.6 CDI76901.1 - 2.3e-10 40.1 0.1 5.7e-10 38.8 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain CDC27 PF09507.10 CDI76901.1 - 0.0016 17.9 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 PBP_like_2 PF12849.7 CDI76901.1 - 0.009 15.7 0.3 0.015 15.0 0.3 1.4 1 0 0 1 1 1 1 PBP superfamily domain TAP_C PF03943.13 CDI76901.1 - 0.016 14.9 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 TAP C-terminal domain DUF1296 PF06972.11 CDI76901.1 - 0.021 14.9 0.1 0.61 10.3 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1296) RskA PF10099.9 CDI76901.1 - 2 8.7 16.0 1.8 8.8 8.1 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA IQ PF00612.27 CDI76902.1 - 0.0032 17.1 0.2 0.0094 15.7 0.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Hydrolase_3 PF08282.12 CDI76904.1 - 7.7e-42 143.8 0.0 9.2e-42 143.5 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDI76904.1 - 1.1e-06 28.3 0.0 8.2e-05 22.3 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDI76904.1 - 0.023 15.0 0.0 3.7 7.8 0.0 2.7 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase PFK PF00365.20 CDI76905.1 - 2.1e-54 184.8 0.0 4.8e-34 118.0 0.0 3.2 3 0 0 3 3 3 3 Phosphofructokinase GYF PF02213.16 CDI76906.1 - 2.7e-11 42.9 4.6 2.3e-10 40.0 5.1 2.2 2 0 0 2 2 2 1 GYF domain SARAF PF06682.12 CDI76906.1 - 0.29 10.7 0.0 0.29 10.7 0.0 12.7 5 3 5 11 11 11 0 SOCE-associated regulatory factor of calcium homoeostasis Metallophos PF00149.28 CDI76907.1 - 0.034 14.6 0.0 0.035 14.6 0.0 1.1 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase P22_CoatProtein PF11651.8 CDI76908.1 - 0.0098 14.5 0.4 0.015 13.9 0.4 1.2 1 0 0 1 1 1 1 P22 coat protein - gene protein 5 SR-25 PF10500.9 CDI76909.1 - 0.00028 20.6 2.4 0.00028 20.6 2.4 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein GET2 PF08690.10 CDI76909.1 - 0.016 14.9 3.6 0.41 10.3 0.3 2.3 2 0 0 2 2 2 0 GET complex subunit GET2 NUDIX PF00293.28 CDI76909.1 - 0.024 14.7 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 NUDIX domain AF-4 PF05110.13 CDI76909.1 - 2.5 6.1 10.4 0.1 10.7 4.3 1.7 2 0 0 2 2 2 0 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI76909.1 - 2.6 8.0 15.4 0.84 9.6 4.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Metallophos PF00149.28 CDI76910.1 - 4.6e-29 102.4 0.0 6.8e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_5 PF13854.6 CDI76910.1 - 8.7e-05 22.4 0.0 0.00034 20.5 0.0 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 CDI76910.1 - 0.00035 20.1 0.5 0.033 13.8 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 CDI76910.1 - 0.0099 15.8 0.1 0.047 13.7 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 CDI76910.1 - 0.033 14.2 0.5 0.53 10.3 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain TFIIA PF03153.13 CDI76910.1 - 0.078 13.0 17.0 0.12 12.3 17.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Kelch_6 PF13964.6 CDI76910.1 - 0.16 12.3 0.6 1.7 9.1 0.0 2.6 3 0 0 3 3 3 0 Kelch motif Spt20 PF12090.8 CDI76910.1 - 8.4 5.9 19.4 15 5.1 19.4 1.3 1 0 0 1 1 1 0 Spt20 family WD40 PF00400.32 CDI76911.1 - 7.9e-28 96.1 13.0 2.7e-08 34.3 0.3 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI76911.1 - 2.4e-07 31.0 0.1 0.42 10.9 0.0 5.0 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDI76911.1 - 0.0074 15.0 0.1 5.6 5.5 0.0 3.3 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDI76911.1 - 0.15 11.0 0.3 0.64 8.9 0.2 1.9 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_S9 PF00326.21 CDI76912.1 - 9.6e-09 35.0 1.2 2.7e-06 27.0 0.0 3.0 3 0 0 3 3 3 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDI76912.1 - 1.4e-08 34.3 0.5 7e-05 22.2 0.1 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI76912.1 - 2.6e-06 27.3 0.3 0.00057 19.6 0.2 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDI76912.1 - 0.00017 22.3 0.1 0.00034 21.3 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CDI76912.1 - 0.0012 18.7 0.1 0.011 15.6 0.1 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 CDI76912.1 - 0.032 14.3 0.1 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 TAP-like protein FSH1 PF03959.13 CDI76912.1 - 0.039 13.6 0.2 0.15 11.7 0.0 1.9 1 1 1 2 2 2 0 Serine hydrolase (FSH1) DUF818 PF05677.12 CDI76912.1 - 0.042 12.8 0.1 0.082 11.8 0.1 1.4 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Pyrid_oxidase_2 PF13883.6 CDI76912.1 - 0.067 13.1 0.5 0.097 12.6 0.5 1.2 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Pkinase PF00069.25 CDI76913.1 - 5.1e-12 45.7 0.0 5.1e-12 45.7 0.0 2.8 4 0 0 4 4 4 1 Protein kinase domain DNA_methylase PF00145.17 CDI76913.1 - 7.5 5.8 16.0 0.83 8.9 11.4 1.7 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase DHHC PF01529.20 CDI76915.1 - 0.0034 17.5 5.3 0.0034 17.5 5.3 1.9 1 1 1 2 2 2 1 DHHC palmitoyltransferase DPM3 PF08285.11 CDI76915.1 - 6.3 7.1 8.9 5.7 7.2 4.9 2.3 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) START PF01852.19 CDI76917.1 - 2.3e-05 23.9 0.0 4.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 START domain PsbQ PF05757.11 CDI76917.1 - 0.037 13.8 13.0 0.85 9.3 3.2 2.9 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) TP_methylase PF00590.20 CDI76919.1 - 4.6e-24 85.6 0.1 8.8e-24 84.6 0.1 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UQ_con PF00179.26 CDI76920.1 - 1.3e-47 160.9 0.1 1.5e-47 160.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI76920.1 - 0.00067 19.4 0.0 0.00075 19.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDI76920.1 - 0.0068 16.7 0.0 0.0089 16.3 0.0 1.2 1 0 0 1 1 1 1 RWD domain Rhomboid PF01694.22 CDI76923.1 - 3e-14 53.3 5.3 3e-14 53.3 5.3 1.5 2 0 0 2 2 2 1 Rhomboid family DUF3533 PF12051.8 CDI76923.1 - 0.18 10.7 3.1 0.23 10.3 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) CoaE PF01121.20 CDI76925.1 - 2.1e-48 164.3 0.0 2.7e-48 164.0 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_28 PF13521.6 CDI76925.1 - 6.1e-05 23.3 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDI76925.1 - 0.0089 16.6 0.1 0.034 14.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain DUF2374 PF09574.10 CDI76925.1 - 0.33 10.8 0.0 0.33 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) APG5 PF04106.12 CDI76928.1 - 1.6e-47 162.1 0.0 2e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 TFIIA PF03153.13 CDI76929.1 - 0.16 11.9 15.9 0.12 12.3 8.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76929.1 - 5.6 6.5 17.1 0.96 9.0 6.1 2.3 2 0 0 2 2 2 0 Spt20 family ACPS PF01648.20 CDI76938.1 - 2.2e-17 63.2 0.0 2.7e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily WD40 PF00400.32 CDI76940.1 - 7.3e-11 42.5 6.8 1.3e-05 25.9 0.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI76940.1 - 1.8e-09 37.7 0.1 4.7e-05 23.6 0.1 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDI76940.1 - 0.011 14.4 0.8 0.043 12.5 0.3 2.1 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDI76940.1 - 0.88 8.5 5.5 3.6 6.4 5.1 2.3 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2722 PF10846.8 CDI76942.1 - 0.0013 17.7 2.9 0.0013 17.7 2.9 3.7 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) PQQ_3 PF13570.6 CDI76942.1 - 0.007 16.8 1.4 3.8 8.1 0.3 3.8 2 1 0 2 2 2 2 PQQ-like domain Spt20 PF12090.8 CDI76942.1 - 0.015 14.9 9.0 0.015 14.9 9.0 4.0 4 1 0 4 4 4 0 Spt20 family WD40 PF00400.32 CDI76942.1 - 0.029 15.3 0.1 10 7.2 0.1 3.3 2 0 0 2 2 2 0 WD domain, G-beta repeat WD40 PF00400.32 CDI76944.1 - 2.7e-05 24.8 5.8 0.26 12.2 0.4 4.4 4 1 0 4 4 4 2 WD domain, G-beta repeat Shadoo PF14999.6 CDI76944.1 - 0.012 15.7 7.2 0.02 15.0 7.2 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Dehydrin PF00257.19 CDI76944.1 - 0.047 14.2 2.1 0.073 13.6 2.1 1.3 1 0 0 1 1 1 0 Dehydrin Nup160 PF11715.8 CDI76944.1 - 0.59 8.7 5.9 6.9 5.2 1.8 2.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SR-25 PF10500.9 CDI76944.1 - 0.63 9.6 5.9 0.84 9.2 5.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Kelch_1 PF01344.25 CDI76951.1 - 8.5e-17 60.5 0.3 2.8e-08 33.2 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 CDI76951.1 - 4.7e-11 42.5 1.8 5.8e-07 29.4 0.1 2.3 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI76951.1 - 5.1e-11 42.1 1.7 3.9e-05 23.5 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 CDI76951.1 - 2.2e-10 40.5 3.6 0.00074 19.7 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI76951.1 - 1.1e-09 38.2 0.8 7.2e-05 22.9 0.1 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_5 PF13854.6 CDI76951.1 - 5.5e-09 35.8 0.4 0.0027 17.7 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Presenilin PF01080.17 CDI76951.1 - 0.00035 19.5 9.9 0.00035 19.5 9.9 1.1 1 0 0 1 1 1 1 Presenilin Ndc1_Nup PF09531.10 CDI76951.1 - 5.1 5.7 14.2 5.4 5.6 14.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RAMP4 PF06624.12 CDI76955.1 - 1.6e-15 56.9 0.7 2.4e-15 56.3 0.2 1.5 2 0 0 2 2 2 1 Ribosome associated membrane protein RAMP4 PA26 PF04636.13 CDI76955.1 - 0.044 12.7 0.0 0.05 12.5 0.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) LEM PF03020.15 CDI76955.1 - 0.22 11.1 0.3 20 4.8 0.0 2.5 2 0 0 2 2 2 0 LEM domain Avl9 PF09794.9 CDI76956.1 - 5.2e-15 55.0 0.0 7.9e-14 51.1 0.0 2.3 1 1 0 1 1 1 1 Transport protein Avl9 DENN PF02141.21 CDI76956.1 - 0.0044 17.0 0.3 0.027 14.4 0.1 2.2 2 0 0 2 2 2 1 DENN (AEX-3) domain SPA PF08616.10 CDI76956.1 - 0.0067 16.4 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 1 Stabilization of polarity axis MORN PF02493.20 CDI76957.1 - 7.8e-26 88.4 37.0 0.00017 21.2 0.3 9.2 10 0 0 10 10 10 7 MORN repeat eIF3_p135 PF12807.7 CDI76958.1 - 5.3e-06 26.6 0.7 1.9e-05 24.8 0.0 2.3 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 DSPc PF00782.20 CDI76959.1 - 1.4e-20 73.4 0.0 5.8e-17 61.8 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDI76959.1 - 0.023 14.3 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Gelsolin PF00626.22 CDI76959.1 - 0.068 13.1 2.3 0.12 12.2 0.0 2.8 3 0 0 3 3 3 0 Gelsolin repeat AAA_12 PF13087.6 CDI76960.1 - 3.2e-50 170.5 0.0 9.4e-50 169.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CDI76960.1 - 1.7e-39 136.2 1.8 1.2e-26 94.0 0.0 3.1 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 CDI76960.1 - 7.6e-07 29.0 0.0 3.7e-06 26.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDI76960.1 - 2e-06 28.2 0.2 9.8e-06 26.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain dsrm PF00035.26 CDI76960.1 - 0.00082 20.0 0.8 0.44 11.3 0.0 3.0 2 0 0 2 2 2 1 Double-stranded RNA binding motif PIF1 PF05970.14 CDI76960.1 - 0.0013 18.0 0.0 0.15 11.2 0.0 2.3 2 0 0 2 2 2 1 PIF1-like helicase ResIII PF04851.15 CDI76960.1 - 0.049 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 CDI76960.1 - 0.088 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 CDI76960.1 - 0.12 12.3 0.0 0.39 10.6 0.0 1.8 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 CDI76960.1 - 0.27 10.4 2.2 14 4.8 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) G-patch PF01585.23 CDI76961.1 - 1.2e-14 54.0 1.1 2.1e-14 53.1 1.1 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDI76961.1 - 0.00036 20.6 0.4 0.0011 19.0 0.4 1.8 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 CDI76961.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CBP4 PF07960.11 CDI76961.1 - 0.087 12.7 0.4 0.087 12.7 0.4 1.7 2 0 0 2 2 2 0 CBP4 AAA_lid_7 PF17867.1 CDI76962.1 - 0.0092 16.2 0.1 0.046 13.9 0.0 2.1 2 1 0 2 2 2 1 Midasin AAA lid domain COPI_assoc PF08507.10 CDI76963.1 - 5.3e-08 33.0 3.9 6.8e-08 32.6 3.9 1.1 1 0 0 1 1 1 1 COPI associated protein DUF4064 PF13273.6 CDI76965.1 - 2.8 8.3 4.9 30 5.0 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) FAM199X PF15814.5 CDI76966.1 - 0.13 11.3 1.6 0.14 11.2 1.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X Adeno_PV PF03910.13 CDI76966.1 - 0.95 8.1 3.8 0.94 8.1 3.8 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV DUF1633 PF07794.11 CDI76966.1 - 6.8 4.7 8.0 7.9 4.5 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Ribosomal_L22 PF00237.19 CDI76968.1 - 1.2e-10 41.6 0.2 1.6e-10 41.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e zf-RING_2 PF13639.6 CDI76969.1 - 4.2e-07 30.2 8.1 6.3e-06 26.4 4.1 2.6 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 CDI76969.1 - 2.3e-06 27.8 2.7 2.8e-06 27.5 0.9 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDI76969.1 - 3.2e-05 23.7 8.6 9.4e-05 22.2 3.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI76969.1 - 0.0031 17.3 7.8 0.014 15.3 3.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI76969.1 - 0.0054 16.7 5.2 0.0075 16.2 2.1 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CDI76969.1 - 0.044 13.8 1.7 0.1 12.7 1.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CDI76969.1 - 0.046 13.8 8.4 0.38 10.8 5.3 3.3 2 1 0 2 2 2 0 RING-type zinc-finger zf-RING_11 PF17123.5 CDI76969.1 - 0.075 12.8 3.7 0.87 9.4 1.4 2.6 2 0 0 2 2 2 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 CDI76969.1 - 0.14 11.8 2.3 0.39 10.4 2.3 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Protamine_P2 PF00841.19 CDI76969.1 - 0.22 12.1 9.6 0.41 11.2 9.6 1.3 1 0 0 1 1 1 0 Sperm histone P2 zf-C3HC4_3 PF13920.6 CDI76969.1 - 0.3 11.0 8.4 0.6 10.0 3.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDI76969.1 - 0.43 10.5 11.6 0.06 13.2 5.3 2.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDI76969.1 - 0.77 10.0 6.9 0.66 10.2 2.7 2.8 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DDHD PF02862.17 CDI76969.1 - 1.2 9.3 13.4 1.9 8.6 0.6 2.8 3 0 0 3 3 3 0 DDHD domain RskA PF10099.9 CDI76970.1 - 0.00091 19.6 0.4 0.00099 19.4 0.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA RCR PF12273.8 CDI76970.1 - 0.0024 18.5 1.6 0.0033 18.1 1.6 1.4 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Coilin_N PF15862.5 CDI76970.1 - 0.0036 17.1 4.7 0.0036 17.1 4.7 1.4 2 0 0 2 2 2 1 Coilin N-terminus DUF4834 PF16118.5 CDI76970.1 - 0.014 16.3 6.7 0.016 16.1 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI76970.1 - 0.019 14.6 27.9 0.023 14.3 27.9 1.1 1 0 0 1 1 1 0 Spt20 family Acetyltransf_1 PF00583.25 CDI76970.1 - 0.033 14.4 0.0 0.05 13.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family CPSF100_C PF13299.6 CDI76970.1 - 0.05 13.8 4.1 0.057 13.6 4.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EOS1 PF12326.8 CDI76970.1 - 0.061 13.2 0.4 0.065 13.2 0.4 1.1 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 CDI76970.1 - 0.19 11.8 0.9 0.16 12.0 0.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 CDI76970.1 - 0.2 11.6 22.2 0.21 11.5 22.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI76970.1 - 0.41 10.4 3.7 0.43 10.3 3.7 1.2 1 0 0 1 1 1 0 Connexin SpoIIP PF07454.11 CDI76970.1 - 0.68 9.3 8.5 0.75 9.2 8.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI76970.1 - 2.8 6.6 9.9 3.8 6.2 9.9 1.2 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 CDI76970.1 - 3.8 6.8 9.4 4.8 6.4 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3408 PF11888.8 CDI76970.1 - 5.4 7.2 13.8 7.1 6.8 13.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) TERB2 PF15101.6 CDI76970.1 - 6.1 6.8 13.7 7.6 6.5 13.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI76970.1 - 7.1 5.5 17.2 4.1 6.3 15.8 1.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1980 PF09323.10 CDI76970.1 - 7.2 6.5 8.4 9.4 6.1 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Presenilin PF01080.17 CDI76971.1 - 0.34 9.6 14.0 0.38 9.5 14.0 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 CDI76971.1 - 0.44 9.0 12.6 0.56 8.6 12.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 CDI76971.1 - 0.84 8.6 14.3 0.88 8.5 14.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sin_N PF04801.13 CDI76971.1 - 3.1 6.9 27.1 4.1 6.5 27.1 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Membralin PF09746.9 CDI76971.1 - 3.5 6.6 9.3 3.8 6.5 9.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein MIIP PF15734.5 CDI76971.1 - 3.7 6.9 11.7 4.5 6.6 11.7 1.1 1 0 0 1 1 1 0 Migration and invasion-inhibitory ALMT PF11744.8 CDI76971.1 - 5.8 5.6 9.1 6.4 5.5 9.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Exonuc_VII_L PF02601.15 CDI76971.1 - 6.9 6.1 18.6 9.4 5.7 18.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Otopetrin PF03189.13 CDI76971.1 - 8.6 5.1 7.5 9.7 4.9 7.5 1.1 1 0 0 1 1 1 0 Otopetrin MDM10 PF12519.8 CDI76971.1 - 9.7 4.9 11.3 12 4.6 11.3 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PAT1 PF09770.9 CDI76971.1 - 10 4.3 36.2 12 4.0 36.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SR-25 PF10500.9 CDI76973.1 - 0.071 12.7 16.0 0.097 12.3 16.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Vfa1 PF08432.10 CDI76973.1 - 0.31 11.3 27.2 0.35 11.2 27.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 BAF1_ABF1 PF04684.13 CDI76973.1 - 0.44 9.5 18.7 0.47 9.4 18.7 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor NOA36 PF06524.12 CDI76973.1 - 0.64 9.3 23.0 0.72 9.1 23.0 1.0 1 0 0 1 1 1 0 NOA36 protein Spt20 PF12090.8 CDI76973.1 - 0.69 9.5 26.1 0.79 9.3 26.1 1.1 1 0 0 1 1 1 0 Spt20 family Slu7 PF11708.8 CDI76973.1 - 1.4 8.6 24.1 1.5 8.5 24.1 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor GP67 PF17634.2 CDI76973.1 - 1.7 9.2 20.9 2.2 8.7 20.9 1.3 1 0 0 1 1 1 0 Gene product 67 Macoilin PF09726.9 CDI76973.1 - 3 6.3 12.7 3.3 6.2 12.7 1.1 1 0 0 1 1 1 0 Macoilin family Nucleo_P87 PF07267.11 CDI76973.1 - 4.9 5.9 16.0 5.2 5.8 16.0 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC27 PF09507.10 CDI76973.1 - 5.5 6.3 26.3 7.5 5.8 26.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4746 PF15928.5 CDI76973.1 - 9 5.6 18.4 9.8 5.5 18.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4834 PF16118.5 CDI76974.1 - 0.55 11.2 0.0 0.55 11.2 0.0 9.3 8 2 1 9 9 9 0 Domain of unknown function (DUF4834) FAM104 PF15434.6 CDI76974.1 - 6.8 7.3 0.0 6.8 7.3 0.0 10.0 7 2 3 10 10 10 0 Family 104 ANAPC4_WD40 PF12894.7 CDI76976.1 - 1.9e-06 28.0 0.1 0.0087 16.3 0.0 4.1 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI76976.1 - 1.5e-05 25.6 4.2 0.058 14.3 0.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat SUIM_assoc PF16619.5 CDI76976.1 - 0.0017 18.4 0.3 0.0017 18.4 0.3 8.0 7 1 0 7 7 7 3 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI76976.1 - 0.0055 16.8 76.9 0.29 11.1 2.3 5.3 5 0 0 5 5 5 5 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI76976.1 - 0.0065 16.1 4.0 0.0065 16.1 4.0 5.8 5 1 0 5 5 5 4 Spt20 family RRM_1 PF00076.22 CDI76977.1 - 4.7e-05 23.1 0.1 0.00021 21.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDHD PF02862.17 CDI76977.1 - 0.014 15.6 0.1 0.014 15.6 0.1 7.1 4 3 0 4 4 4 0 DDHD domain SAPS PF04499.15 CDI76978.1 - 0.0044 15.9 10.1 0.0044 15.9 10.1 2.2 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein SLC12 PF03522.15 CDI76978.1 - 0.99 8.4 43.3 1.1 8.1 16.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 LAP1C PF05609.12 CDI76978.1 - 1 8.3 38.9 0.63 9.1 10.9 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) AAA_11 PF13086.6 CDI76978.1 - 5.4 6.7 33.2 4.4 7.0 17.2 2.2 2 0 0 2 2 2 0 AAA domain Peptidase_S64 PF08192.11 CDI76978.1 - 9.1 4.6 51.2 1.3 7.5 14.8 2.1 2 0 0 2 2 2 0 Peptidase family S64 adh_short PF00106.25 CDI76979.1 - 1.2e-17 64.0 14.5 2.3e-12 46.8 0.3 4.0 3 2 0 4 4 4 3 short chain dehydrogenase adh_short_C2 PF13561.6 CDI76979.1 - 2.9e-07 30.3 0.6 2.9e-07 30.3 0.6 3.6 2 1 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase SPX PF03105.19 CDI76979.1 - 7.9e-05 22.7 0.0 7.9e-05 22.7 0.0 2.9 1 1 0 2 2 2 1 SPX domain FHIPEP PF00771.20 CDI76979.1 - 1.4 7.2 9.1 0.48 8.8 1.6 2.3 2 0 0 2 2 2 0 FHIPEP family Consortin_C PF15281.6 CDI76979.1 - 2.9 7.9 6.6 1.5 8.8 0.1 3.1 3 0 0 3 3 3 0 Consortin C-terminus Peptidase_S49_N PF08496.10 CDI76979.1 - 4.1 7.4 15.9 1.6 8.8 2.0 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PAT1 PF09770.9 CDI76979.1 - 4.5 5.4 26.3 2.6 6.2 10.3 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Orf78 PF06024.12 CDI76979.1 - 7.5 6.9 20.7 6.9 7.0 0.3 5.1 5 0 0 5 5 5 0 Orf78 (ac78) SpoIIP PF07454.11 CDI76979.1 - 8.2 5.8 20.0 0.52 9.7 4.1 3.2 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) PIP5K PF01504.18 CDI76980.1 - 0.24 10.6 0.0 0.24 10.6 0.0 5.6 6 0 0 6 6 6 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF3792 PF12670.7 CDI76980.1 - 0.92 9.7 5.8 3.2 7.9 5.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) SUIM_assoc PF16619.5 CDI76981.1 - 0.00021 21.3 0.2 0.00032 20.7 0.2 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI76981.1 - 0.0049 17.2 10.7 0.0049 17.2 10.7 4.2 2 2 1 3 3 3 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI76981.1 - 0.18 11.4 10.4 0.28 10.8 10.4 1.3 1 0 0 1 1 1 0 Spt20 family Macoilin PF09726.9 CDI76981.1 - 6.8 5.1 11.5 13 4.2 11.5 1.4 1 0 0 1 1 1 0 Macoilin family FAM199X PF15814.5 CDI76982.1 - 0.048 12.7 18.5 0.065 12.3 18.5 1.2 1 0 0 1 1 1 0 Protein family FAM199X RAP1 PF07218.11 CDI76982.1 - 0.13 10.5 17.6 0.16 10.2 17.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) GREB1 PF15782.5 CDI76982.1 - 0.33 8.0 11.5 0.42 7.7 11.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CCDC106 PF15794.5 CDI76982.1 - 0.72 9.5 15.5 0.94 9.1 15.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Period_C PF12114.8 CDI76982.1 - 1.4 8.4 20.0 2.1 7.9 20.0 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Zip PF02535.22 CDI76982.1 - 1.7 7.7 5.0 2.2 7.4 5.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 CDI76982.1 - 2.6 8.0 5.0 3.1 7.8 5.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI76982.1 - 2.7 6.7 11.8 3.4 6.3 11.8 1.1 1 0 0 1 1 1 0 Presenilin CCDC53 PF10152.9 CDI76982.1 - 4.6 7.7 9.7 6.2 7.2 9.7 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Ribonuc_red_lgC PF02867.15 CDI76984.1 - 5.1e-81 272.8 0.0 2e-55 188.3 0.0 2.3 1 1 1 2 2 2 2 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CDI76984.1 - 6.8e-22 77.3 0.1 2e-21 75.8 0.0 1.9 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CDI76984.1 - 2.3e-10 40.9 0.0 4.6e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 ATP cone domain Vps23_core PF09454.10 CDI76984.1 - 0.035 14.0 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 Vps23 core domain Apt1 PF10351.9 CDI76984.1 - 0.62 8.8 18.7 1.7 7.4 3.9 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI76984.1 - 5 5.6 23.4 3.6 6.0 8.6 2.1 2 0 0 2 2 2 0 Macoilin family Ribosomal_L19e PF01280.20 CDI76986.1 - 5e-54 182.3 22.6 5.6e-54 182.1 12.4 2.9 1 1 1 2 2 2 1 Ribosomal protein L19e DUF4358 PF14270.6 CDI76986.1 - 0.13 12.6 3.2 0.2 12.0 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4358) YhzD PF14120.6 CDI76986.1 - 1.8 8.7 4.8 0.89 9.7 1.8 2.0 2 0 0 2 2 2 0 YhzD-like protein Rsc14 PF08586.10 CDI76989.1 - 0.53 11.1 3.0 1 10.2 3.0 1.4 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit TFIIA PF03153.13 CDI76990.1 - 0.012 15.6 20.5 0.017 15.2 20.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ELM2 PF01448.24 CDI76990.1 - 0.13 13.0 0.3 0.13 13.0 0.3 2.4 3 1 0 3 3 3 0 ELM2 domain PP2C PF00481.21 CDI76994.1 - 8.2e-17 61.7 12.7 1.3e-07 31.5 0.0 5.4 6 0 0 6 6 6 3 Protein phosphatase 2C S1 PF00575.23 CDI76995.1 - 3.8e-07 30.3 0.0 0.028 14.7 0.0 3.4 2 1 1 3 3 3 2 S1 RNA binding domain RAP1 PF07218.11 CDI76995.1 - 8.3 4.5 11.5 14 3.8 11.5 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.9 CDI76996.1 - 0.00081 18.4 9.8 0.00081 18.4 9.8 5.2 4 1 0 5 5 5 1 Golgi-body localisation protein domain BAF1_ABF1 PF04684.13 CDI76996.1 - 0.0041 16.2 4.0 0.0041 16.2 4.0 4.7 3 2 1 4 4 4 2 BAF1 / ABF1 chromatin reorganising factor NARP1 PF12569.8 CDI76996.1 - 3.1 6.6 31.6 5.1 5.9 11.3 2.7 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Pro_isomerase PF00160.21 CDI76997.1 - 1.4e-32 113.1 1.1 3.6e-32 111.8 0.0 2.1 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SUIM_assoc PF16619.5 CDI76997.1 - 0.017 15.2 5.2 0.017 15.2 5.2 3.9 2 1 0 2 2 1 0 Unstructured region C-term to UIM in Ataxin3 BORG_CEP PF14957.6 CDI76997.1 - 0.38 11.9 9.2 1.1 10.5 1.1 3.2 3 0 0 3 3 3 0 Cdc42 effector EPL1 PF10513.9 CDI76997.1 - 0.72 10.2 14.1 1.4 9.3 3.7 3.2 3 0 0 3 3 3 0 Enhancer of polycomb-like DUF2380 PF09533.10 CDI76997.1 - 1.7 8.2 8.9 0.04 13.5 1.6 2.1 2 0 0 2 2 1 0 Predicted lipoprotein of unknown function (DUF2380) Pex14_N PF04695.13 CDI76997.1 - 2.8 8.6 29.2 0.28 11.8 8.4 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RskA PF10099.9 CDI76997.1 - 2.9 8.1 34.5 1.9 8.8 16.3 3.2 3 0 0 3 3 3 0 Anti-sigma-K factor rskA LIM_bind PF01803.16 CDI76997.1 - 4.3 6.8 14.0 1.4 8.4 0.6 2.6 3 0 0 3 3 3 0 LIM-domain binding protein DUF4834 PF16118.5 CDI76997.1 - 5.3 8.1 18.7 14 6.8 0.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF4770 PF15994.5 CDI76997.1 - 6.9 6.9 20.2 2.7 8.2 2.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) STAC2_u1 PF16664.5 CDI76997.1 - 6.9 7.1 13.7 0.4 11.1 1.7 3.3 3 0 0 3 3 3 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 MSP1_C PF07462.11 CDI76997.1 - 7.3 5.2 13.4 4.9 5.7 9.7 2.0 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus Pyr_redox_2 PF07992.14 CDI76998.1 - 1.7e-45 155.5 0.3 1.3e-43 149.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDI76998.1 - 3.8e-23 81.8 1.3 4.7e-22 78.3 0.1 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDI76998.1 - 7.7e-15 55.2 0.0 2.9e-14 53.4 0.0 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CDI76998.1 - 6.8e-05 22.8 0.7 0.00063 19.7 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDI76998.1 - 0.00013 21.4 1.1 0.0016 17.8 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CDI76998.1 - 0.0015 17.8 11.6 0.0058 16.0 0.0 2.7 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CDI76998.1 - 0.0027 17.3 0.2 0.0027 17.3 0.2 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.22 CDI76998.1 - 0.0028 16.8 10.0 0.041 13.0 2.0 2.9 3 0 0 3 3 3 2 Glucose inhibited division protein A K_oxygenase PF13434.6 CDI76998.1 - 0.01 15.0 0.1 0.15 11.2 0.1 2.2 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CDI76998.1 - 0.079 13.2 0.1 0.079 13.2 0.1 3.3 2 1 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CDI76998.1 - 2.2 7.3 6.3 0.15 11.1 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Spt20 PF12090.8 CDI76998.1 - 3.7 7.1 7.0 6.6 6.3 7.0 1.3 1 0 0 1 1 1 0 Spt20 family KH_1 PF00013.29 CDI76999.1 - 1.2e-23 82.7 0.0 3.7e-07 29.9 0.0 4.4 4 0 0 4 4 4 3 KH domain Tmemb_9 PF05434.11 CDI76999.1 - 0.014 15.3 3.7 0.027 14.4 3.7 1.4 1 0 0 1 1 1 0 TMEM9 DUF2207 PF09972.9 CDI76999.1 - 0.21 10.3 0.3 0.29 9.9 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4175 PF13779.6 CDI76999.1 - 1.1 7.1 3.2 1.9 6.3 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Shisa PF13908.6 CDI76999.1 - 2 8.6 4.6 4.8 7.4 4.6 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ECSCR PF15820.5 CDI76999.1 - 3.6 7.5 10.2 8.1 6.3 10.2 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF2244 PF10003.9 CDI76999.1 - 3.6 7.3 10.7 13 5.5 9.4 2.3 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Baculo_11_kDa PF06143.11 CDI76999.1 - 6.6 6.4 10.7 15 5.2 10.7 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family Pkinase PF00069.25 CDI77000.1 - 3.4e-80 269.2 0.0 5e-80 268.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77000.1 - 1.6e-36 125.9 0.0 2.3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI77000.1 - 3e-10 38.9 4.0 0.00022 20.5 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 CDI77000.1 - 3.3e-09 37.1 0.7 0.00021 21.6 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 CDI77000.1 - 1.2e-06 28.2 2.9 0.0078 16.0 0.1 3.9 4 0 0 4 4 4 1 EF-hand domain pair Pkinase_fungal PF17667.1 CDI77000.1 - 2.3e-06 26.7 0.0 4.4e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDI77000.1 - 2.3e-05 23.8 0.0 4.2e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Kinase-like EF-hand_5 PF13202.6 CDI77000.1 - 0.0002 20.7 1.4 0.15 11.6 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CDI77000.1 - 0.00031 20.4 1.0 0.5 10.4 0.1 3.8 3 0 0 3 3 3 1 EF-hand domain APH PF01636.23 CDI77000.1 - 0.00035 20.6 0.0 0.0008 19.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDI77000.1 - 0.024 14.0 0.0 0.053 12.9 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NRBF2 PF08961.10 CDI77001.1 - 0.0083 15.8 15.5 0.13 11.9 1.0 3.1 1 1 1 3 3 3 2 Nuclear receptor-binding factor 2, autophagy regulator DegS PF05384.11 CDI77001.1 - 0.015 14.8 10.4 0.026 14.0 3.7 2.4 2 0 0 2 2 2 0 Sensor protein DegS GIT1_C PF12205.8 CDI77001.1 - 0.029 14.5 3.9 0.63 10.2 0.3 2.5 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF4407 PF14362.6 CDI77001.1 - 0.13 11.5 8.9 1.5 8.1 8.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2855 PF11017.8 CDI77001.1 - 0.16 11.7 0.5 0.29 10.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) WXG100 PF06013.12 CDI77001.1 - 0.18 12.1 2.2 2.3 8.5 0.2 2.7 2 0 0 2 2 2 0 Proteins of 100 residues with WXG BLOC1_2 PF10046.9 CDI77001.1 - 0.31 11.3 8.6 0.98 9.8 1.3 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LPD5 PF18799.1 CDI77001.1 - 0.46 10.9 4.8 0.16 12.4 0.7 2.1 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 5 DUF4208 PF13907.6 CDI77001.1 - 0.84 10.1 4.5 2.2 8.8 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) V_ATPase_I PF01496.19 CDI77001.1 - 1.1 7.1 4.8 0.68 7.8 0.1 2.0 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family TSC22 PF01166.18 CDI77001.1 - 1.4 9.3 8.0 0.085 13.2 1.1 2.5 2 1 0 2 2 2 0 TSC-22/dip/bun family HALZ PF02183.18 CDI77001.1 - 1.5 9.1 8.8 1.8 8.8 0.2 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper BRE1 PF08647.11 CDI77001.1 - 1.9 8.6 13.0 4.6 7.4 3.1 3.3 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 CDI77001.1 - 2 9.1 7.0 4.2 8.1 0.2 3.0 2 1 0 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 CDI77001.1 - 2.3 8.7 17.5 0.27 11.7 1.6 3.8 2 1 0 2 2 2 0 Cell division protein ZapB LPP PF04728.13 CDI77001.1 - 2.5 8.6 9.6 0.17 12.3 2.1 2.8 4 0 0 4 4 3 0 Lipoprotein leucine-zipper TMF_DNA_bd PF12329.8 CDI77001.1 - 3.7 7.6 14.7 2.9 8.0 0.9 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Arm PF00514.23 CDI77002.1 - 0.0047 16.9 0.3 0.026 14.6 0.0 2.3 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat DUF4471 PF14740.6 CDI77009.1 - 0.01 15.1 2.5 0.012 14.8 2.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) FAM222A PF15258.6 CDI77009.1 - 0.027 13.6 5.5 0.032 13.4 5.5 1.1 1 0 0 1 1 1 0 Protein family of FAM222A RR_TM4-6 PF06459.12 CDI77009.1 - 2.3 8.0 10.8 3.1 7.6 10.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rrn6 PF10214.9 CDI77009.1 - 3.5 6.0 13.3 4.2 5.7 13.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor NEMP PF10225.9 CDI77009.1 - 3.6 7.2 6.0 5.4 6.6 6.0 1.3 1 0 0 1 1 1 0 NEMP family Exonuc_VII_L PF02601.15 CDI77009.1 - 5.2 6.5 13.0 6.8 6.2 13.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Band_3_cyto PF07565.13 CDI77009.1 - 5.7 6.7 10.8 8.4 6.1 10.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TPR_11 PF13414.6 CDI77012.1 - 0.009 15.7 0.7 0.042 13.5 0.0 2.2 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.28 CDI77012.1 - 0.048 13.5 1.1 0.075 12.9 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_33 PF13671.6 CDI77013.1 - 0.00021 21.5 0.1 0.00091 19.4 0.2 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CDI77013.1 - 0.00054 20.0 0.1 0.001 19.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDI77013.1 - 0.00056 20.3 0.0 0.003 18.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MCM_bind PF09739.9 CDI77013.1 - 0.0013 17.3 3.9 0.003 16.1 3.9 1.6 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor AAA_22 PF13401.6 CDI77013.1 - 0.0016 18.7 0.0 0.0046 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 CDI77013.1 - 0.0029 17.7 2.8 0.67 10.1 0.1 3.3 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_18 PF13238.6 CDI77013.1 - 0.0039 17.7 0.0 0.0091 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Presenilin PF01080.17 CDI77013.1 - 0.004 16.0 5.4 0.004 16.0 5.4 2.6 3 0 0 3 3 3 1 Presenilin 6PF2K PF01591.18 CDI77013.1 - 0.0058 16.0 0.0 0.93 8.8 0.0 2.4 2 0 0 2 2 2 1 6-phosphofructo-2-kinase RuvB_N PF05496.12 CDI77013.1 - 0.0094 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDI77013.1 - 0.01 15.3 0.0 0.029 13.8 0.0 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CDI77013.1 - 0.013 15.9 4.3 0.023 15.1 0.7 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 CDI77013.1 - 0.042 14.1 0.2 0.13 12.5 0.0 1.7 1 1 1 2 2 2 0 AAA domain SOG2 PF10428.9 CDI77013.1 - 0.066 12.4 33.7 0.066 12.4 29.3 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein AAA_17 PF13207.6 CDI77013.1 - 0.076 13.4 0.5 0.29 11.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDI77013.1 - 0.094 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Filament_head PF04732.14 CDI77013.1 - 0.11 13.4 43.8 0.16 12.9 15.4 3.7 3 0 0 3 3 3 0 Intermediate filament head (DNA binding) region DUF1387 PF07139.11 CDI77013.1 - 0.11 12.2 0.0 0.11 12.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1387) AAA_7 PF12775.7 CDI77013.1 - 0.15 11.6 0.0 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Utp14 PF04615.13 CDI77013.1 - 0.16 10.5 13.8 0.0078 14.8 7.3 2.0 2 0 0 2 2 2 0 Utp14 protein Pex14_N PF04695.13 CDI77013.1 - 1.9 9.2 32.6 0.47 11.1 5.2 4.9 4 1 1 5 5 5 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SDA1 PF05285.12 CDI77013.1 - 2.1 7.7 17.9 0.1 12.0 10.6 2.1 2 0 0 2 2 2 0 SDA1 CCSAP PF15748.5 CDI77013.1 - 4.8 7.3 34.1 2.2 8.4 17.9 3.3 3 0 0 3 3 3 0 Centriole, cilia and spindle-associated Peptidase_S64 PF08192.11 CDI77013.1 - 5.4 5.4 26.5 0.017 13.7 14.7 2.3 3 0 0 3 3 3 0 Peptidase family S64 DNA_pol_B PF00136.21 CDI77016.1 - 8.8e-61 206.0 0.0 1.2e-60 205.6 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDI77016.1 - 4.3e-09 36.0 0.0 6.7e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 CDI77016.1 - 0.008 15.1 0.0 0.086 11.7 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DUF501 PF04417.12 CDI77020.1 - 3.8e-13 49.4 6.2 8.9e-08 32.0 0.0 3.3 3 1 1 4 4 4 2 Protein of unknown function (DUF501) RAP PF08373.10 CDI77022.1 - 6.1e-08 32.6 0.0 1.1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 RAP domain LptF_LptG PF03739.14 CDI77023.1 - 0.27 10.0 1.0 0.5 9.2 1.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG FAM35_C PF15793.5 CDI77025.1 - 0.063 12.7 0.1 15 5.0 0.0 2.4 2 0 0 2 2 2 0 Protein family FAM35, C-terminal Actin PF00022.19 CDI77026.1 - 1.1e-47 162.6 1.3 1.4e-34 119.4 1.9 3.4 2 2 0 2 2 2 2 Actin SUIM_assoc PF16619.5 CDI77026.1 - 0.086 12.9 19.4 1.1 9.3 0.5 4.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF1676 PF07898.13 CDI77026.1 - 0.3 11.1 0.0 0.3 11.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) ERCC4 PF02732.15 CDI77027.1 - 6.6e-13 49.2 9.1 9.1e-13 48.7 0.0 4.1 4 0 0 4 4 4 1 ERCC4 domain DUF2722 PF10846.8 CDI77027.1 - 0.00026 20.1 3.3 0.00026 20.1 3.3 5.4 5 0 0 5 5 5 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI77027.1 - 0.0019 18.3 82.7 0.027 14.5 22.2 5.3 5 0 0 5 5 5 4 Transcription factor IIA, alpha/beta subunit DUF4366 PF14283.6 CDI77027.1 - 1.3 9.0 15.3 0.65 10.0 0.1 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4366) Apt1 PF10351.9 CDI77027.1 - 3.5 6.4 31.3 0.54 9.0 3.1 4.1 4 0 0 4 4 4 0 Golgi-body localisation protein domain EPL1 PF10513.9 CDI77027.1 - 5.9 7.3 30.7 3.4 8.0 3.8 5.0 4 1 0 4 4 4 0 Enhancer of polycomb-like PBP1_TM PF14812.6 CDI77028.1 - 0.014 15.7 1.1 0.014 15.7 1.1 3.8 4 1 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2417 PF10329.9 CDI77028.1 - 0.15 11.4 0.0 0.15 11.4 0.0 2.7 4 0 0 4 4 4 0 Region of unknown function (DUF2417) OAD_gamma PF04277.13 CDI77029.1 - 0.0075 16.8 4.5 0.18 12.4 2.2 3.0 2 1 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain PepSY_TM PF03929.16 CDI77029.1 - 0.01 15.5 0.3 0.019 14.7 0.3 1.4 1 0 0 1 1 1 0 PepSY-associated TM region DUF2207 PF09972.9 CDI77029.1 - 0.12 11.1 0.9 0.21 10.3 0.1 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) FAM176 PF14851.6 CDI77029.1 - 0.14 11.8 1.3 0.3 10.7 0.0 2.0 2 1 1 3 3 3 0 FAM176 family TFIIE-A_C PF11521.8 CDI77029.1 - 3.8 7.9 9.6 0.24 11.7 2.0 2.4 2 1 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha SUIM_assoc PF16619.5 CDI77029.1 - 7.4 6.7 19.3 0.57 10.3 0.9 3.3 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 ASF1_hist_chap PF04729.13 CDI77030.1 - 7.3e-61 204.6 0.0 1.1e-60 204.1 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone DDHD PF02862.17 CDI77030.1 - 0.6 10.2 5.5 7.4 6.7 0.0 2.3 2 0 0 2 2 2 0 DDHD domain RskA PF10099.9 CDI77031.1 - 0.00027 21.3 0.0 0.00027 21.3 0.0 12.3 5 3 5 10 10 10 2 Anti-sigma-K factor rskA BCNT PF07572.12 CDI77032.1 - 1.4e-08 34.7 0.3 2.5e-08 33.9 0.3 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development RIFIN PF02009.16 CDI77032.1 - 1.7 8.4 12.4 2.2 8.1 12.4 1.1 1 0 0 1 1 1 0 Rifin NAM-associated PF14303.6 CDI77033.1 - 0.0016 19.2 0.0 0.0033 18.1 0.0 1.6 1 1 0 1 1 1 1 No apical meristem-associated C-terminal domain Macoilin PF09726.9 CDI77033.1 - 0.74 8.3 5.0 0.87 8.1 5.0 1.1 1 0 0 1 1 1 0 Macoilin family AAA_9 PF12781.7 CDI77035.1 - 1.1e-20 73.8 1.0 1.1e-20 73.8 1.0 2.4 2 0 0 2 2 2 1 ATP-binding dynein motor region Ldi PF18566.1 CDI77035.1 - 0.25 10.8 6.4 0.49 9.8 6.4 1.6 1 1 0 1 1 1 0 Linalool dehydratase/isomerase DUF2573 PF10835.8 CDI77035.1 - 0.25 11.7 2.8 1.1 9.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2573) FAM150 PF15129.6 CDI77035.1 - 8.3 6.6 7.3 20 5.4 7.3 1.6 1 0 0 1 1 1 0 FAM150 family PEPCK_ATP PF01293.20 CDI77036.1 - 1.6e-156 521.6 0.0 1.8e-156 521.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 CDI77036.1 - 0.016 15.6 0.0 0.036 14.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CDI77036.1 - 0.079 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDI77036.1 - 0.2 11.5 0.4 0.41 10.4 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ChaC PF04752.12 CDI77038.1 - 4.9 7.2 5.6 0.61 10.1 0.4 2.1 2 1 0 2 2 2 0 ChaC-like protein Pro-rich PF15240.6 CDI77040.1 - 0.0075 16.6 0.0 0.0075 16.6 0.0 4.8 3 2 1 4 4 4 1 Proline-rich RRM_1 PF00076.22 CDI77046.1 - 1.9e-31 107.7 0.8 1.8e-16 59.7 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4551 PF15087.6 CDI77046.1 - 2.1 7.1 7.9 3.7 6.3 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) ChAPs PF09295.10 CDI77048.1 - 9.8e-23 80.8 0.0 9.8e-23 80.8 0.0 2.8 3 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 CDI77048.1 - 0.064 14.1 7.0 0.055 14.3 1.5 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Macoilin PF09726.9 CDI77051.1 - 0.013 14.1 2.2 0.017 13.7 2.2 1.2 1 0 0 1 1 1 0 Macoilin family DUF1635 PF07795.11 CDI77051.1 - 7.5 6.3 6.9 5.9 6.7 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) SUIM_assoc PF16619.5 CDI77053.1 - 0.0034 17.4 1.6 0.0034 17.4 1.6 2.6 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI77053.1 - 0.0046 16.6 0.4 0.0046 16.6 0.4 1.7 2 0 0 2 2 2 1 Spt20 family Roughex PF06020.11 CDI77053.1 - 8.1 5.4 5.4 16 4.5 5.4 1.4 1 0 0 1 1 1 0 Drosophila roughex protein PHO4 PF01384.20 CDI77054.1 - 1.1 8.2 5.7 0.089 11.8 0.3 1.8 3 0 0 3 3 3 0 Phosphate transporter family Spt20 PF12090.8 CDI77055.1 - 0.017 14.7 3.9 0.026 14.2 3.9 1.2 1 0 0 1 1 1 0 Spt20 family RRM_1 PF00076.22 CDI77055.1 - 0.022 14.6 0.0 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3384 PF11864.8 CDI77055.1 - 0.094 11.6 0.1 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) Lin-8 PF03353.15 CDI77055.1 - 0.36 10.3 3.3 0.55 9.7 3.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Pheromone PF08015.11 CDI77055.1 - 0.45 11.6 7.1 0.32 12.1 2.1 3.3 3 0 0 3 3 3 0 Fungal mating-type pheromone Apt1 PF10351.9 CDI77055.1 - 2.1 7.1 10.1 0.41 9.4 5.5 1.8 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI77055.1 - 2.6 6.7 4.0 4.1 6.1 4.0 1.3 1 0 0 1 1 1 0 Presenilin SNARE PF05739.19 CDI77056.1 - 0.032 14.2 0.1 0.032 14.2 0.1 2.5 2 0 0 2 2 2 0 SNARE domain DUF572 PF04502.13 CDI77056.1 - 0.47 10.0 16.2 0.07 12.7 12.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF572) SieB PF14163.6 CDI77056.1 - 3.8 7.0 6.7 0.43 10.1 0.9 2.3 2 0 0 2 2 2 0 Super-infection exclusion protein B LSM PF01423.22 CDI77057.1 - 0.00017 21.2 0.3 0.0003 20.4 0.3 1.4 1 1 0 1 1 1 1 LSM domain Pox_F12L PF03337.13 CDI77057.1 - 0.043 12.0 0.0 0.053 11.7 0.0 1.0 1 0 0 1 1 1 0 Poxvirus F12L protein DAGK_acc PF00609.19 CDI77058.1 - 2.3e-18 67.0 0.0 3.4e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 CDI77058.1 - 0.0015 18.2 0.0 0.0029 17.2 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pannexin_like PF12534.8 CDI77059.1 - 0.96 8.5 3.7 1.3 8.0 3.7 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 FancD2 PF14631.6 CDI77059.1 - 1.5 6.1 6.9 2.1 5.7 6.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Band_3_cyto PF07565.13 CDI77059.1 - 2.6 7.8 8.7 3.6 7.3 8.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Bul1_N PF04425.12 CDI77059.1 - 3.9 6.1 8.6 5.3 5.7 8.6 1.0 1 0 0 1 1 1 0 Bul1 N terminus Spt20 PF12090.8 CDI77059.1 - 4.1 6.9 23.2 6.1 6.4 23.2 1.2 1 0 0 1 1 1 0 Spt20 family Connexin PF00029.19 CDI77059.1 - 4.4 7.0 4.2 6.2 6.5 4.2 1.1 1 0 0 1 1 1 0 Connexin MFS_1 PF07690.16 CDI77061.1 - 8.8e-15 54.5 16.4 1.5e-14 53.7 16.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDI77061.1 - 0.0014 17.6 9.9 0.0028 16.6 0.0 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter CDK2AP PF09806.9 CDI77061.1 - 0.068 13.2 2.5 7.6 6.5 0.1 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein AIF-MLS PF14962.6 CDI77061.1 - 0.22 11.5 0.7 0.41 10.6 0.7 1.3 1 0 0 1 1 1 0 Mitochondria Localisation Sequence TMEM51 PF15345.6 CDI77061.1 - 0.8 9.5 2.7 0.8 9.5 0.1 2.0 2 0 0 2 2 2 0 Transmembrane protein 51 SUIM_assoc PF16619.5 CDI77061.1 - 1.4 9.1 22.4 3.9 7.6 6.6 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 E_Pc_C PF06752.12 CDI77061.1 - 3 7.9 20.5 4.6 7.3 5.8 2.2 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus DUF31 PF01732.16 CDI77062.1 - 0.0055 16.3 7.4 0.013 15.1 7.0 1.9 1 1 0 1 1 1 1 Putative peptidase (DUF31) Sec34 PF04136.15 CDI77062.1 - 0.0087 15.9 10.7 0.0087 15.9 10.7 3.7 3 1 0 3 3 3 1 Sec34-like family CCDC53 PF10152.9 CDI77062.1 - 0.012 16.0 1.0 0.012 16.0 1.0 3.3 2 1 0 3 3 3 0 Subunit CCDC53 of WASH complex MKT1_N PF12247.8 CDI77062.1 - 0.21 12.0 0.2 0.21 12.0 0.2 2.4 3 0 0 3 3 3 0 Temperature dependent protein affecting M2 dsRNA replication Spt20 PF12090.8 CDI77063.1 - 2.5e-05 24.0 59.2 0.0061 16.2 37.4 2.3 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI77063.1 - 3.2e-05 24.3 3.1 3.2e-05 24.3 3.1 2.9 2 2 0 2 2 2 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI77063.1 - 0.032 13.2 54.5 0.024 13.6 23.9 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 eIF-3_zeta PF05091.12 CDI77063.1 - 0.049 12.6 30.7 0.051 12.6 18.7 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC27 PF09507.10 CDI77063.1 - 0.49 9.7 43.4 0.31 10.4 35.8 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 ABC2_membrane_2 PF12679.7 CDI77063.1 - 2 7.6 4.4 7.1 5.8 0.8 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein 7tm_1 PF00001.21 CDI77063.1 - 2.2 7.5 6.6 1.4 8.2 2.0 2.2 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) PAT1 PF09770.9 CDI77063.1 - 2.5 6.3 36.3 1.2 7.4 21.0 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 MDM10 PF12519.8 CDI77063.1 - 5.3 5.8 26.7 11 4.8 22.1 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 AF-4 PF05110.13 CDI77063.1 - 5.3 5.0 45.5 3.3 5.7 3.4 2.3 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF4050 PF13259.6 CDI77063.1 - 5.6 7.2 28.5 8.4 6.7 21.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) CNDH2_C PF16858.5 CDI77063.1 - 8.4 6.2 34.8 9.3 6.0 26.2 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term XRN_M PF17846.1 CDI77063.1 - 9.8 5.0 30.2 7.9 5.3 23.7 2.2 2 0 0 2 2 2 0 Xrn1 helical domain Pkinase PF00069.25 CDI77065.1 - 0.00012 21.6 0.0 0.00012 21.6 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain eIF3_subunit PF08597.10 CDI77065.1 - 0.0024 17.8 13.3 0.0035 17.3 13.3 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit SR-25 PF10500.9 CDI77065.1 - 0.054 13.1 16.0 0.078 12.6 16.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CDI77065.1 - 0.082 10.0 10.6 0.092 9.9 10.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Zip PF02535.22 CDI77065.1 - 0.14 11.3 1.8 0.14 11.3 1.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Borrelia_P83 PF05262.11 CDI77065.1 - 0.19 10.2 16.0 0.23 9.9 16.0 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Hydin_ADK PF17213.3 CDI77065.1 - 0.19 12.0 9.5 0.26 11.5 9.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 CDI77065.1 - 0.66 8.7 13.3 0.75 8.5 13.3 1.1 1 0 0 1 1 1 0 Presenilin DDRGK PF09756.9 CDI77065.1 - 0.86 9.2 20.8 1 8.9 20.8 1.1 1 0 0 1 1 1 0 DDRGK domain TFIIA PF03153.13 CDI77065.1 - 0.9 9.5 24.3 1.2 9.1 24.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Bud13 PF09736.9 CDI77065.1 - 0.91 9.9 18.0 1.3 9.5 18.0 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex AF-4 PF05110.13 CDI77065.1 - 1.1 7.3 17.0 1.3 7.0 17.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF3292 PF11696.8 CDI77065.1 - 1.4 7.2 7.2 1.7 7.0 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) MDM10 PF12519.8 CDI77065.1 - 1.8 7.4 8.0 2.1 7.1 8.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Lin-8 PF03353.15 CDI77065.1 - 2.3 7.7 16.0 2.9 7.4 16.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 CDI77065.1 - 2.3 7.1 10.5 2.8 6.9 10.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Dicty_REP PF05086.12 CDI77065.1 - 2.4 6.0 5.4 2.8 5.8 5.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PA26 PF04636.13 CDI77065.1 - 3.9 6.3 9.0 4.8 6.0 9.0 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Macoilin PF09726.9 CDI77065.1 - 4 5.9 11.9 5.2 5.5 11.9 1.2 1 0 0 1 1 1 0 Macoilin family Activator_LAG-3 PF11498.8 CDI77065.1 - 4.8 6.0 34.1 6.1 5.7 34.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Neur_chan_memb PF02932.16 CDI77065.1 - 5.2 7.1 9.0 6.3 6.8 9.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S64 PF08192.11 CDI77065.1 - 5.8 5.3 13.0 6.9 5.0 13.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 NPR3 PF03666.13 CDI77065.1 - 6.4 5.5 13.3 7.3 5.3 13.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 CDI77065.1 - 6.4 6.5 15.0 8.4 6.1 15.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 CDI77065.1 - 9 5.2 16.1 12 4.7 16.1 1.2 1 0 0 1 1 1 0 Paf1 Ndc1_Nup PF09531.10 CDI77065.1 - 9.1 4.8 9.7 11 4.5 9.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HEAT_EZ PF13513.6 CDI77068.1 - 5.3e-11 42.8 22.9 2.1e-06 28.1 0.3 9.1 7 2 2 9 9 9 3 HEAT-like repeat HEAT PF02985.22 CDI77068.1 - 1e-06 28.4 17.4 0.0021 18.2 0.0 8.0 7 1 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 CDI77068.1 - 0.00052 20.4 19.6 0.2 12.1 0.0 6.9 5 2 0 6 6 6 3 HEAT repeats Importin_rep_4 PF18808.1 CDI77068.1 - 0.1 12.9 0.0 1.2 9.4 0.0 3.0 3 0 0 3 3 3 0 Importin repeat Arm PF00514.23 CDI77068.1 - 3.6 7.8 7.4 5 7.3 0.5 4.9 4 1 0 4 4 4 0 Armadillo/beta-catenin-like repeat Tim44 PF04280.15 CDI77069.1 - 1.9e-13 50.7 0.0 1.9e-13 50.7 0.0 2.0 2 0 0 2 2 2 1 Tim44-like domain RskA PF10099.9 CDI77069.1 - 4.2 7.6 25.6 0.12 12.6 8.1 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DFRP_C PF16543.5 CDI77069.1 - 9.8 6.7 12.7 1.5 9.4 6.7 2.3 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 RRM_1 PF00076.22 CDI77071.1 - 3.6e-13 49.1 0.0 1.2e-12 47.5 0.0 1.7 1 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI77071.1 - 0.00018 21.5 0.0 0.00044 20.3 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif Vps54 PF07928.12 CDI77072.1 - 2.7e-20 73.2 1.9 2.7e-20 73.2 1.9 6.7 8 2 0 8 8 8 1 Vps54-like protein Ribosomal_60s PF00428.19 CDI77073.1 - 0.67 10.6 8.9 1.6 9.4 8.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein RskA PF10099.9 CDI77074.1 - 0.00012 22.4 3.2 0.00012 22.4 3.2 4.8 2 2 2 4 4 4 1 Anti-sigma-K factor rskA RMI2 PF16100.5 CDI77074.1 - 0.00068 19.5 2.6 0.014 15.2 0.4 2.8 2 1 1 3 3 3 1 RecQ-mediated genome instability protein 2 SUIM_assoc PF16619.5 CDI77074.1 - 0.014 15.5 4.9 0.014 15.5 4.9 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Ank_2 PF12796.7 CDI77075.1 - 2.8e-08 34.2 0.1 5.9e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI77075.1 - 5.2e-08 33.3 0.1 0.0001 22.8 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI77075.1 - 4.6e-07 30.0 0.1 1.2e-06 28.7 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 CDI77075.1 - 6e-06 26.5 0.1 0.0029 18.0 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CDI77075.1 - 0.0023 18.3 0.0 0.0088 16.5 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat KGK PF08872.10 CDI77075.1 - 0.18 12.3 1.2 3.5 8.1 0.3 2.3 2 0 0 2 2 2 0 KGK domain Spt20 PF12090.8 CDI77075.1 - 6.3 6.3 31.4 0.015 14.9 4.9 3.2 3 0 0 3 3 3 0 Spt20 family BOP1NT PF08145.12 CDI77078.1 - 2.7e-47 161.9 4.0 2.7e-47 161.9 4.0 1.7 2 0 0 2 2 2 1 BOP1NT (NUC169) domain Dehydrin PF00257.19 CDI77078.1 - 0.0036 17.9 1.7 0.0036 17.9 1.7 2.5 3 0 0 3 3 3 1 Dehydrin SR-25 PF10500.9 CDI77078.1 - 0.016 14.8 2.0 0.016 14.8 2.0 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Menin PF05053.13 CDI77078.1 - 0.15 10.4 10.5 0.25 9.6 10.5 1.2 1 0 0 1 1 1 0 Menin BRF1 PF07741.13 CDI77078.1 - 0.2 12.0 4.3 4.9 7.6 0.1 2.7 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Suf PF05843.14 CDI77078.1 - 0.53 10.2 7.8 1.1 9.2 7.8 1.5 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4533 PF15047.6 CDI77078.1 - 0.84 9.2 4.1 0.62 9.6 2.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4533) DUF2052 PF09747.9 CDI77079.1 - 0.4 10.8 26.6 0.48 10.5 26.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Draxin PF15550.6 CDI77079.1 - 0.43 10.4 20.6 0.51 10.2 20.6 1.0 1 0 0 1 1 1 0 Draxin Med5 PF08689.10 CDI77079.1 - 0.88 7.3 15.2 0.96 7.2 15.2 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 Otopetrin PF03189.13 CDI77079.1 - 0.92 8.3 16.2 1.1 8.0 16.2 1.1 1 0 0 1 1 1 0 Otopetrin Presenilin PF01080.17 CDI77079.1 - 1 8.1 31.3 1.2 7.8 31.3 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI77079.1 - 2 8.4 24.9 2.1 8.3 24.9 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Rtf2 PF04641.12 CDI77079.1 - 2.1 7.6 25.1 2.7 7.3 25.1 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 CDI77079.1 - 3 7.6 30.6 3.6 7.3 30.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 CDI77079.1 - 3.3 5.7 23.8 4 5.4 23.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Zip PF02535.22 CDI77079.1 - 3.6 6.7 20.7 4.1 6.5 20.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 CDI77079.1 - 3.8 6.5 18.7 5.5 5.9 18.7 1.3 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 CDI77079.1 - 3.9 5.7 26.2 4.3 5.5 26.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4775 PF16001.5 CDI77079.1 - 4.6 6.6 20.1 5.1 6.4 20.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) ALMT PF11744.8 CDI77079.1 - 4.7 5.9 23.0 5.3 5.8 23.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CCSAP PF15748.5 CDI77079.1 - 4.7 7.3 30.5 5.4 7.1 30.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated V_ATPase_I PF01496.19 CDI77079.1 - 4.9 4.9 25.2 6.4 4.6 25.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S64 PF08192.11 CDI77079.1 - 5.4 5.4 26.6 5.9 5.2 26.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4746 PF15928.5 CDI77079.1 - 6.1 6.2 21.7 6.9 6.0 21.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4638 PF15472.6 CDI77079.1 - 6.7 6.4 22.3 9.8 5.8 22.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SLC12 PF03522.15 CDI77079.1 - 8.6 5.3 29.1 10 5.0 29.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 eIF-1a PF01176.19 CDI77080.1 - 3e-08 33.3 0.2 4.3e-08 32.9 0.2 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Serglycin PF04360.12 CDI77080.1 - 0.012 15.6 0.6 0.014 15.4 0.6 1.3 1 0 0 1 1 1 0 Serglycin TMEM247 PF15444.6 CDI77080.1 - 0.027 14.5 1.6 0.027 14.5 1.6 1.1 1 0 0 1 1 1 0 Transmembrane protein 247 RskA PF10099.9 CDI77084.1 - 0.00019 21.8 0.0 0.00019 21.8 0.0 13.1 3 2 6 10 10 10 3 Anti-sigma-K factor rskA RabGAP-TBC PF00566.18 CDI77084.1 - 0.057 13.1 0.0 0.057 13.1 0.0 6.3 7 0 0 7 7 7 0 Rab-GTPase-TBC domain Pyrid_oxidase_2 PF13883.6 CDI77084.1 - 1.6 8.6 4.5 2.1 8.3 0.2 2.6 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase DUF21 PF01595.20 CDI77084.1 - 8.2 6.1 9.5 2.8 7.6 0.4 3.7 3 0 0 3 3 3 0 Cyclin M transmembrane N-terminal domain FH2 PF02181.23 CDI77086.1 - 6.1e-16 58.5 11.7 1.9e-09 37.2 1.8 4.6 4 1 2 6 6 6 2 Formin Homology 2 Domain ANAPC_CDC26 PF10471.9 CDI77087.1 - 0.0078 17.0 6.9 0.0096 16.7 6.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Chorion_2 PF03964.15 CDI77087.1 - 0.012 16.4 3.5 0.015 16.1 3.5 1.1 1 0 0 1 1 1 0 Chorion family 2 Ribosomal_60s PF00428.19 CDI77087.1 - 0.28 11.8 5.6 0.3 11.7 5.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Spt20 PF12090.8 CDI77087.1 - 0.53 9.8 5.9 0.51 9.9 5.9 1.0 1 0 0 1 1 1 0 Spt20 family Dicty_REP PF05086.12 CDI77088.1 - 0.81 7.6 9.6 1.2 7.0 9.6 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SRP54 PF00448.22 CDI77089.1 - 8.2e-75 250.7 0.1 1.7e-74 249.7 0.0 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CDI77089.1 - 1.2e-29 102.8 0.2 1.2e-29 102.8 0.2 2.6 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 CDI77089.1 - 3e-13 49.8 0.5 4.8e-12 45.9 0.2 2.8 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain cobW PF02492.19 CDI77089.1 - 2.6e-06 27.2 0.3 3.3e-05 23.6 0.1 2.7 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDI77089.1 - 6.9e-06 26.3 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI77089.1 - 5.5e-05 23.6 0.0 0.00028 21.3 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDI77089.1 - 0.00045 20.0 0.0 0.0022 17.7 0.0 2.2 1 0 0 1 1 1 1 AAA domain DUF4310 PF14187.6 CDI77089.1 - 0.00071 19.3 0.2 0.0014 18.3 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4310) Zeta_toxin PF06414.12 CDI77089.1 - 0.002 17.4 0.0 0.004 16.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 CDI77089.1 - 0.0044 17.5 0.9 0.026 14.9 0.1 2.7 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 CDI77089.1 - 0.0046 16.4 2.1 0.83 9.1 0.0 2.7 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit CbiA PF01656.23 CDI77089.1 - 0.0062 16.6 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Methyltransf_24 PF13578.6 CDI77089.1 - 0.01 16.8 0.1 0.025 15.6 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain ResIII PF04851.15 CDI77089.1 - 0.012 15.6 0.5 0.11 12.6 0.5 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit MeaB PF03308.16 CDI77089.1 - 0.016 14.2 0.4 0.12 11.3 0.0 2.4 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 CDI77089.1 - 0.026 14.8 1.5 0.085 13.1 0.1 2.7 3 1 0 3 3 3 0 AAA domain APS_kinase PF01583.20 CDI77089.1 - 0.055 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase DRE2_N PF16803.5 CDI77089.1 - 0.077 13.2 0.1 6.5 7.0 0.0 2.7 3 0 0 3 3 2 0 Fe-S cluster assembly protein DRE2 N-terminus MobB PF03205.14 CDI77089.1 - 0.13 12.2 0.0 0.51 10.2 0.0 2.1 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DpnI_C PF17726.1 CDI77089.1 - 0.14 12.3 0.8 0.56 10.4 0.0 2.2 2 0 0 2 2 2 0 Dam-replacing HTH domain MMR_HSR1 PF01926.23 CDI77089.1 - 0.14 12.2 0.5 1.2 9.3 0.2 2.6 2 1 0 2 2 1 0 50S ribosome-binding GTPase IMUP PF15761.5 CDI77089.1 - 0.16 12.7 10.1 0.34 11.6 10.1 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein AAA_23 PF13476.6 CDI77089.1 - 0.2 12.2 1.0 1.5 9.3 0.0 2.4 3 0 0 3 3 2 0 AAA domain RAP1 PF07218.11 CDI77089.1 - 0.53 8.5 2.8 0.76 8.0 2.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.9 CDI77089.1 - 0.62 9.6 9.7 0.23 11.0 6.8 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein eIF-3_zeta PF05091.12 CDI77090.1 - 1.9 7.4 14.7 0.19 10.6 7.6 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI77090.1 - 2.7 7.9 63.8 5.4 6.9 37.1 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Brix PF04427.18 CDI77091.1 - 5.1e-14 52.8 0.0 9.6e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Brix domain Collagen PF01391.18 CDI77093.1 - 5.9e-05 22.7 48.6 5.9e-05 22.7 48.6 2.2 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Apt1 PF10351.9 CDI77093.1 - 2.2 7.0 4.1 3.3 6.5 4.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Spt20 PF12090.8 CDI77094.1 - 0.0029 17.3 22.9 0.0041 16.8 22.9 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI77094.1 - 0.0032 17.5 18.9 0.0037 17.3 18.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI77094.1 - 0.053 14.2 16.4 0.082 13.6 16.4 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.8 CDI77094.1 - 0.076 11.8 8.4 0.096 11.4 8.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC27 PF09507.10 CDI77094.1 - 0.13 11.6 13.7 0.16 11.3 13.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Plasmodium_Vir PF05795.11 CDI77094.1 - 0.2 11.0 5.2 0.27 10.6 5.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PAT1 PF09770.9 CDI77094.1 - 0.41 8.9 18.7 0.5 8.6 18.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 CDI77094.1 - 0.68 9.3 9.2 0.94 8.9 9.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI77094.1 - 0.72 8.6 9.9 0.83 8.3 9.9 1.1 1 0 0 1 1 1 0 Presenilin Polyoma_coat2 PF00761.20 CDI77094.1 - 0.77 9.4 8.7 8.1 6.1 0.0 2.1 2 0 0 2 2 2 0 Polyomavirus coat protein DUF4407 PF14362.6 CDI77094.1 - 0.94 8.8 3.8 1.3 8.3 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 CDI77094.1 - 1.2 7.4 7.1 1.5 7.0 7.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.10 CDI77094.1 - 1.2 7.8 8.6 1.4 7.5 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup eIF-3_zeta PF05091.12 CDI77094.1 - 1.5 7.7 9.5 2 7.3 9.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SLC12 PF03522.15 CDI77094.1 - 1.8 7.5 6.8 2.5 7.0 6.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CobT PF06213.12 CDI77094.1 - 3.1 7.1 17.4 4.3 6.6 17.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CDI77094.1 - 3.3 7.9 8.0 7.3 6.7 7.7 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI77094.1 - 4.3 7.3 5.9 5.8 6.9 5.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDI77094.1 - 4.8 6.9 13.4 6.5 6.5 13.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1180 PF06679.12 CDI77094.1 - 6.1 7.2 7.1 10 6.5 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) TERB2 PF15101.6 CDI77094.1 - 7.7 6.5 12.3 12 5.8 12.3 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2722 PF10846.8 CDI77096.1 - 0.00052 19.1 9.0 0.00052 19.1 9.0 3.8 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) DUF411 PF04214.13 CDI77096.1 - 0.0035 17.3 0.0 5.6 7.0 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function, DUF SPX PF03105.19 CDI77096.1 - 0.93 9.3 24.4 1.9 8.3 24.4 1.5 1 0 0 1 1 1 0 SPX domain Androgen_recep PF02166.16 CDI77097.1 - 1.2e-05 24.3 2.6 1.2e-05 24.3 2.6 6.7 5 1 2 7 7 7 2 Androgen receptor HOOK PF05622.12 CDI77097.1 - 0.00039 18.7 24.4 0.00039 18.7 24.4 2.5 3 0 0 3 3 3 1 HOOK protein Mod_r PF07200.13 CDI77097.1 - 0.0024 18.0 7.9 0.0024 18.0 7.9 4.8 5 1 0 5 5 5 2 Modifier of rudimentary (Mod(r)) protein FlxA PF14282.6 CDI77097.1 - 0.0056 16.6 15.7 0.0056 16.6 15.7 6.4 6 1 0 6 6 6 1 FlxA-like protein SR-25 PF10500.9 CDI77099.1 - 0.012 15.2 5.4 0.012 15.2 5.4 4.5 4 1 0 4 4 4 0 Nuclear RNA-splicing-associated protein HGTP_anticodon2 PF12745.7 CDI77100.1 - 0.28 10.6 8.8 0.3 10.6 8.8 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs ALMT PF11744.8 CDI77100.1 - 8.7 5.1 10.2 9.8 4.9 10.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PNISR PF15996.5 CDI77100.1 - 9.3 6.5 8.4 10 6.4 8.4 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR UPF0564 PF10595.9 CDI77101.1 - 0.0045 16.1 3.8 0.0045 16.1 3.8 2.9 3 0 0 3 3 3 1 Uncharacterised protein family UPF0564 DUF2207 PF09972.9 CDI77101.1 - 0.14 10.9 3.1 1.2 7.8 0.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) BAF1_ABF1 PF04684.13 CDI77101.1 - 1.8 7.5 41.9 0.19 10.7 21.1 2.3 1 1 1 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DUF4746 PF15928.5 CDI77101.1 - 2.1 7.7 19.1 0.94 8.8 6.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) PRP3 PF08572.10 CDI77101.1 - 3.4 7.3 30.8 0.9 9.2 14.4 2.3 2 0 0 2 2 2 0 pre-mRNA processing factor 3 (PRP3) PAT1 PF09770.9 CDI77101.1 - 6.9 4.8 44.1 3.8 5.7 27.7 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RRM_1 PF00076.22 CDI77102.1 - 1.4e-39 133.7 0.0 8.3e-11 41.6 0.1 6.7 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 CDI77102.1 - 2.6e-10 40.1 0.0 2.6e-10 40.1 0.0 4.8 5 1 1 6 6 6 1 Protein kinase domain LRR_8 PF13855.6 CDI77102.1 - 3.5e-07 29.9 12.1 0.032 14.0 2.3 4.5 3 1 1 4 4 4 3 Leucine rich repeat RRM_5 PF13893.6 CDI77102.1 - 0.00012 21.7 0.8 0.0065 16.1 0.0 4.0 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI77102.1 - 0.001 18.9 0.9 0.28 11.1 0.0 4.1 4 0 0 4 4 4 1 Occluded RNA-recognition motif LRR_4 PF12799.7 CDI77102.1 - 0.0024 18.2 22.3 0.12 12.8 0.5 5.1 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) RskA PF10099.9 CDI77102.1 - 0.0088 16.4 0.0 0.0088 16.4 0.0 12.8 5 3 4 9 9 9 2 Anti-sigma-K factor rskA PAP1 PF08601.10 CDI77102.1 - 3.1 7.4 0.0 3.1 7.4 0.0 8.8 5 3 2 8 8 8 0 Transcription factor PAP1 FAM76 PF16046.5 CDI77103.1 - 1 8.7 6.7 1.4 8.2 6.7 1.1 1 0 0 1 1 1 0 FAM76 protein Sec3_C PF09763.9 CDI77103.1 - 1.3 7.3 6.7 1.6 7.0 6.7 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 Apt1 PF10351.9 CDI77103.1 - 1.8 7.4 12.1 2.2 7.0 12.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC45 PF02724.14 CDI77103.1 - 6.9 4.8 12.9 8.5 4.5 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RAP1 PF07218.11 CDI77103.1 - 9.6 4.3 7.8 12 4.1 7.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hid1 PF12722.7 CDI77103.1 - 9.9 4.1 9.1 11 4.0 9.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DctM PF06808.12 CDI77104.1 - 0.00027 19.9 0.4 0.00042 19.3 0.4 1.2 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component PT PF04886.12 CDI77104.1 - 0.012 15.1 30.4 0.038 13.5 24.1 2.9 2 1 0 2 2 2 0 PT repeat Cyt_bd_oxida_II PF02322.15 CDI77104.1 - 0.026 13.9 1.3 0.04 13.3 1.3 1.3 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II Wzy_C PF04932.15 CDI77104.1 - 0.15 11.7 0.7 0.31 10.6 0.7 1.5 1 0 0 1 1 1 0 O-Antigen ligase DUF4131 PF13567.6 CDI77104.1 - 8.4 6.0 6.9 4 7.1 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) FAM176 PF14851.6 CDI77106.1 - 0.035 13.8 17.0 0.73 9.5 0.6 4.1 4 0 0 4 4 4 0 FAM176 family FAM60A PF15396.6 CDI77106.1 - 0.1 12.6 21.2 1.9 8.5 1.8 3.9 4 0 0 4 4 4 0 Protein Family FAM60A Connexin PF00029.19 CDI77106.1 - 0.24 11.1 21.0 1.6 8.5 2.9 3.5 3 0 0 3 3 3 0 Connexin FAM76 PF16046.5 CDI77106.1 - 2.4 7.5 34.7 3.5 6.9 6.9 3.5 3 0 0 3 3 3 0 FAM76 protein SpoIIP PF07454.11 CDI77106.1 - 3.6 6.9 30.5 1 8.7 1.4 3.5 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Peroxin-13_N PF04088.13 CDI77106.1 - 4.1 7.7 19.4 1.3 9.3 0.7 4.5 4 0 0 4 4 4 0 Peroxin 13, N-terminal region CAF1 PF04857.20 CDI77106.1 - 4.2 6.4 18.5 1.5 7.9 0.1 3.3 3 0 0 3 3 3 0 CAF1 family ribonuclease CSG2 PF16965.5 CDI77106.1 - 7.6 5.4 15.4 2.9 6.7 0.2 3.3 3 0 0 3 3 3 0 Ceramide synthase regulator SR-25 PF10500.9 CDI77107.1 - 0.0077 15.9 20.3 0.0077 15.9 20.3 2.8 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein Methyltransf_34 PF11312.8 CDI77107.1 - 0.87 8.8 20.2 1.7 7.8 20.1 1.4 1 1 0 1 1 1 0 Putative SAM-dependent methyltransferase SelP_N PF04592.14 CDI77107.1 - 4.9 6.5 18.9 13 5.2 18.9 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF5523 PF17661.1 CDI77107.1 - 8.2 6.0 21.1 2.3 7.8 12.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) NAC PF01849.18 CDI77108.1 - 1.6e-16 60.0 0.0 3.9e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 NAC domain PGM_PMM_II PF02879.16 CDI77108.1 - 0.041 14.5 0.4 6.8 7.4 0.1 2.1 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DUF755 PF05501.11 CDI77110.1 - 0.028 14.7 31.7 0.028 14.7 31.7 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF755) Med24_N PF11277.8 CDI77110.1 - 0.15 10.1 25.6 0.19 9.7 25.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Clat_adaptor_s PF01217.20 CDI77111.1 - 9.1e-47 158.6 1.8 8.7e-45 152.1 1.8 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain gerPA PF10676.9 CDI77116.1 - 2.4 8.4 4.6 0.89 9.8 1.1 2.1 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF BUD22 PF09073.10 CDI77117.1 - 0.0038 16.6 36.9 0.0045 16.4 18.7 2.1 2 0 0 2 2 2 2 BUD22 NOA36 PF06524.12 CDI77117.1 - 2.2 7.5 30.5 0.13 11.6 16.9 2.5 2 0 0 2 2 2 0 NOA36 protein Kringle PF00051.18 CDI77118.1 - 3.2e-11 43.4 3.8 7.3e-11 42.2 3.8 1.6 1 0 0 1 1 1 1 Kringle domain MAR_sialic_bdg PF10564.9 CDI77118.1 - 1.1e-06 28.6 0.9 0.007 16.4 0.2 2.6 1 1 1 2 2 2 2 Sialic-acid binding micronemal adhesive repeat PDCD2_C PF04194.13 CDI77119.1 - 8.7e-08 32.4 0.0 8.7e-08 32.4 0.0 3.2 4 0 0 4 4 4 1 Programmed cell death protein 2, C-terminal putative domain RskA PF10099.9 CDI77119.1 - 0.0078 16.5 29.0 0.19 12.0 0.0 4.2 2 2 0 2 2 2 1 Anti-sigma-K factor rskA DUF677 PF05055.12 CDI77119.1 - 0.61 8.9 3.9 1.4 7.7 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF677) SDA1 PF05285.12 CDI77120.1 - 1.6e-37 129.8 22.8 1.6e-37 129.8 22.8 2.9 2 1 1 3 3 3 1 SDA1 NUC130_3NT PF08158.12 CDI77120.1 - 0.00063 20.0 13.0 0.0021 18.3 0.5 4.4 5 0 0 5 5 5 2 NUC130/3NT domain Cyt-b5 PF00173.28 CDI77121.1 - 3.2e-17 62.4 0.0 4.9e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AF-4 PF05110.13 CDI77121.1 - 0.0005 18.3 17.8 0.00059 18.1 17.8 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein EPL1 PF10513.9 CDI77121.1 - 0.047 14.1 0.5 0.072 13.5 0.5 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like CCSAP PF15748.5 CDI77121.1 - 0.82 9.8 9.0 1.3 9.2 9.0 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TFIIA PF03153.13 CDI77121.1 - 2.7 7.9 13.9 3.7 7.5 13.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 CDI77121.1 - 2.8 6.5 8.5 3.1 6.4 8.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 CDI77121.1 - 5.1 5.7 5.9 6.2 5.5 5.9 1.2 1 0 0 1 1 1 0 Presenilin DSPc PF00782.20 CDI77122.1 - 6.4e-16 58.4 0.0 1.4e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF4744 PF15918.5 CDI77122.1 - 0.21 12.4 7.1 0.12 13.3 3.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4744) PepSY_TM PF03929.16 CDI77122.1 - 1.6 8.3 8.8 3.1 7.4 0.4 3.3 3 0 0 3 3 3 0 PepSY-associated TM region CSG2 PF16965.5 CDI77123.1 - 0.013 14.5 0.5 0.22 10.4 0.1 2.0 1 1 1 2 2 2 0 Ceramide synthase regulator DUF747 PF05346.11 CDI77123.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic membrane protein family DUF2207 PF09972.9 CDI77123.1 - 0.17 10.6 0.0 0.22 10.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1418 PF07214.12 CDI77123.1 - 0.32 10.9 1.7 0.83 9.6 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF4666 PF15697.5 CDI77123.1 - 2.1 9.1 5.9 0.82 10.4 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) SR-25 PF10500.9 CDI77124.1 - 0.078 12.6 5.1 0.081 12.5 5.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Activator_LAG-3 PF11498.8 CDI77126.1 - 0.028 13.4 13.1 0.043 12.8 13.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI77126.1 - 0.03 13.9 9.5 0.036 13.7 9.5 1.1 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI77126.1 - 0.14 11.1 5.9 0.17 10.8 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Med3 PF11593.8 CDI77126.1 - 3.6 6.7 9.7 5 6.2 9.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RIBIOP_C PF04950.12 CDI77129.1 - 5.6e-44 150.7 0.1 5.6e-44 150.7 0.1 2.1 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Glyco_hydro_4 PF02056.16 CDI77129.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase Presenilin PF01080.17 CDI77129.1 - 9.2 4.9 7.5 11 4.6 7.5 1.1 1 0 0 1 1 1 0 Presenilin HAD PF12710.7 CDI77130.1 - 0.064 13.7 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Spt20 PF12090.8 CDI77130.1 - 0.56 9.8 10.4 0.85 9.2 10.4 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI77130.1 - 0.71 9.8 12.7 1.2 9.1 12.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4551 PF15087.6 CDI77130.1 - 4 6.1 10.4 5.9 5.6 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DNA_pol_A_exo1 PF01612.20 CDI77135.1 - 1.8e-11 44.1 1.4 1.4e-10 41.1 0.1 2.1 2 0 0 2 2 2 1 3'-5' exonuclease DUF3316 PF11777.8 CDI77135.1 - 0.015 15.4 2.5 0.1 12.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3316) TFIIA PF03153.13 CDI77135.1 - 2.9 7.8 6.9 3.5 7.5 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI77136.1 - 2.8e-06 26.4 15.0 2.9e-06 26.3 15.0 1.2 1 0 0 1 1 1 1 Presenilin HCO3_cotransp PF00955.21 CDI77136.1 - 9e-05 21.5 3.7 0.00012 21.1 3.7 1.1 1 0 0 1 1 1 1 HCO3- transporter family Zip PF02535.22 CDI77136.1 - 0.00018 20.8 7.8 0.00021 20.7 7.8 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter NPR3 PF03666.13 CDI77136.1 - 0.00024 20.1 12.9 0.00027 19.9 12.9 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 PTPRCAP PF15713.5 CDI77136.1 - 0.00051 20.4 18.7 0.00083 19.7 18.7 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated PAT1 PF09770.9 CDI77136.1 - 0.00059 18.3 34.2 0.00067 18.1 34.2 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF4050 PF13259.6 CDI77136.1 - 0.0029 18.0 11.4 0.0039 17.5 11.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4050) GREB1 PF15782.5 CDI77136.1 - 0.0039 14.4 18.5 0.004 14.4 18.5 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Otopetrin PF03189.13 CDI77136.1 - 0.0059 15.5 9.6 0.006 15.5 9.6 1.1 1 0 0 1 1 1 1 Otopetrin CCSAP PF15748.5 CDI77136.1 - 0.0074 16.5 23.6 0.009 16.2 23.6 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated SpoIIP PF07454.11 CDI77136.1 - 0.01 15.3 17.1 0.015 14.8 17.1 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM60A PF15396.6 CDI77136.1 - 0.014 15.5 15.9 0.018 15.1 15.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Endostatin PF06482.11 CDI77136.1 - 0.018 14.5 20.4 0.021 14.3 20.4 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF913 PF06025.12 CDI77136.1 - 0.019 14.0 9.8 0.024 13.6 9.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 CDI77136.1 - 0.024 13.0 16.5 0.027 12.8 16.5 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI77136.1 - 0.024 13.7 21.1 0.027 13.5 21.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Tim54 PF11711.8 CDI77136.1 - 0.039 12.8 14.3 0.052 12.3 14.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5523 PF17661.1 CDI77136.1 - 0.049 13.3 19.4 0.07 12.8 19.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) BORG_CEP PF14957.6 CDI77136.1 - 0.061 14.5 12.6 0.091 13.9 12.6 1.5 1 0 0 1 1 1 0 Cdc42 effector DUF4045 PF13254.6 CDI77136.1 - 0.07 12.8 17.8 0.078 12.6 17.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF2052 PF09747.9 CDI77136.1 - 0.071 13.2 20.7 0.11 12.7 20.7 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 CDI77136.1 - 0.073 12.9 23.1 0.097 12.5 23.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Lin-8 PF03353.15 CDI77136.1 - 0.079 12.5 25.3 0.097 12.2 25.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 CDI77136.1 - 0.085 12.9 20.9 0.1 12.6 20.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 CDI77136.1 - 0.12 11.0 12.7 0.12 11.0 12.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spore_coat_CotO PF14153.6 CDI77136.1 - 0.13 12.2 27.4 0.18 11.7 27.4 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Velvet PF11754.8 CDI77136.1 - 0.16 11.9 21.3 0.22 11.4 21.3 1.2 1 0 0 1 1 1 0 Velvet factor GPCR_chapero_1 PF11904.8 CDI77136.1 - 0.17 11.3 15.0 0.2 11.1 15.0 1.1 1 0 0 1 1 1 0 GPCR-chaperone V_ATPase_I PF01496.19 CDI77136.1 - 0.24 9.3 25.1 0.29 9.0 25.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2370 PF10176.9 CDI77136.1 - 0.28 10.8 11.8 0.39 10.3 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4638 PF15472.6 CDI77136.1 - 0.3 10.8 17.3 0.38 10.4 17.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) FemAB PF02388.16 CDI77136.1 - 0.32 9.8 20.5 0.44 9.4 20.5 1.2 1 0 0 1 1 1 0 FemAB family PIP5K PF01504.18 CDI77136.1 - 0.33 10.1 16.4 0.51 9.5 16.4 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Membralin PF09746.9 CDI77136.1 - 0.4 9.7 13.4 0.47 9.4 13.4 1.2 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 CDI77136.1 - 0.45 9.3 20.8 0.58 8.9 20.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S64 PF08192.11 CDI77136.1 - 0.5 8.8 19.4 0.64 8.4 19.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 AF-4 PF05110.13 CDI77136.1 - 0.55 8.3 29.4 0.59 8.2 29.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein eIF3_subunit PF08597.10 CDI77136.1 - 0.66 9.8 19.2 0.91 9.4 19.2 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit VIT1 PF01988.19 CDI77136.1 - 0.74 9.6 7.7 1.1 9.1 7.7 1.3 1 0 0 1 1 1 0 VIT family Serinc PF03348.15 CDI77136.1 - 1 8.2 15.9 1.4 7.8 15.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Exonuc_VII_L PF02601.15 CDI77136.1 - 1.1 8.7 25.8 1.4 8.5 25.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Kei1 PF08552.11 CDI77136.1 - 1.8 8.4 17.3 3.1 7.6 17.3 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 eIF-3_zeta PF05091.12 CDI77136.1 - 1.9 7.4 34.3 2.5 7.0 34.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPP4R2 PF09184.11 CDI77136.1 - 2 7.9 14.0 2.7 7.5 14.0 1.1 1 0 0 1 1 1 0 PPP4R2 Paramyxo_ncap PF00973.19 CDI77136.1 - 2.2 7.1 17.1 2.6 6.9 17.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein LAP1C PF05609.12 CDI77136.1 - 2.3 7.2 26.7 2.8 7.0 26.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) AAA_11 PF13086.6 CDI77136.1 - 2.4 7.9 26.5 3.4 7.4 26.5 1.2 1 0 0 1 1 1 0 AAA domain Vac7 PF12751.7 CDI77136.1 - 2.9 7.2 16.7 3.6 6.9 16.7 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 DUF2347 PF09804.9 CDI77136.1 - 3 7.4 11.7 4.1 6.9 11.7 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) AUX_IAA PF02309.16 CDI77136.1 - 3.5 7.4 15.9 4.8 7.0 15.9 1.3 1 0 0 1 1 1 0 AUX/IAA family Afi1 PF07792.12 CDI77136.1 - 3.6 8.1 21.2 7.3 7.1 21.2 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2126 PF09899.9 CDI77136.1 - 3.7 5.5 17.3 5.1 5.1 17.3 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Rrn6 PF10214.9 CDI77136.1 - 4.3 5.7 28.2 4.5 5.6 28.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Gti1_Pac2 PF09729.9 CDI77136.1 - 4.6 7.3 23.8 7.1 6.7 23.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family SID-1_RNA_chan PF13965.6 CDI77136.1 - 4.8 5.5 12.2 5.9 5.2 12.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4746 PF15928.5 CDI77136.1 - 5.7 6.3 18.7 8.1 5.8 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDRGK PF09756.9 CDI77136.1 - 6 6.4 34.0 9.6 5.8 34.0 1.4 1 0 0 1 1 1 0 DDRGK domain TRAP_alpha PF03896.16 CDI77136.1 - 6.7 5.8 12.2 1.6 7.8 8.3 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Cellulose_synt PF03552.14 CDI77136.1 - 7.5 4.9 10.5 9.4 4.6 10.5 1.1 1 0 0 1 1 1 0 Cellulose synthase Hid1 PF12722.7 CDI77136.1 - 7.7 4.5 26.5 9.9 4.1 26.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TAF4 PF05236.14 CDI77136.1 - 8.1 6.1 27.3 19 4.9 27.3 1.7 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family XRN_M PF17846.1 CDI77136.1 - 8.5 5.2 19.4 11 4.9 19.4 1.1 1 0 0 1 1 1 0 Xrn1 helical domain CAF1 PF04857.20 CDI77136.1 - 8.7 5.4 16.8 12 5.0 16.8 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease DUF853 PF05872.12 CDI77136.1 - 8.9 4.8 15.9 13 4.2 15.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DSPn PF14671.6 CDI77137.1 - 3.9e-46 157.0 0.1 1.1e-45 155.6 0.1 1.8 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 CDI77137.1 - 3.2e-09 36.7 0.0 6.3e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDI77137.1 - 0.0014 18.3 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CDI77137.1 - 0.0029 17.7 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate SR-25 PF10500.9 CDI77137.1 - 0.08 12.6 21.8 0.03 14.0 11.5 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Methyltrans_SAM PF10672.9 CDI77138.1 - 8.9e-09 34.9 0.0 2.4e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 S-adenosylmethionine-dependent methyltransferase MTS PF05175.14 CDI77138.1 - 5.7e-08 32.5 0.1 0.00061 19.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase small domain PUA_3 PF17785.1 CDI77138.1 - 0.00078 19.2 0.0 0.0024 17.7 0.0 1.8 1 1 0 1 1 1 1 PUA-like domain Methyltransf_25 PF13649.6 CDI77138.1 - 0.00091 19.9 0.0 0.005 17.5 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI77138.1 - 0.0013 18.5 0.0 0.69 9.7 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Cons_hypoth95 PF03602.15 CDI77138.1 - 0.0028 17.3 0.2 1.4 8.6 0.3 2.3 2 0 0 2 2 2 2 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 CDI77138.1 - 0.0031 17.5 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDI77138.1 - 0.015 14.7 0.1 0.027 13.8 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CDI77138.1 - 0.091 12.1 0.0 10 5.4 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family N6-adenineMlase PF10237.9 CDI77138.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Pkinase PF00069.25 CDI77139.1 - 5e-34 117.9 0.0 7.7e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77139.1 - 5.2e-24 84.9 0.0 7.8e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDI77139.1 - 0.0039 17.1 0.0 0.0084 16.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Exo_endo_phos PF03372.23 CDI77140.1 - 8.7e-07 28.7 0.0 2.1e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family IMPDH PF00478.25 CDI77143.1 - 3e-126 421.1 5.0 3.8e-126 420.7 5.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CDI77143.1 - 1e-11 45.1 0.1 0.0003 21.2 0.0 2.8 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 CDI77143.1 - 1e-09 37.9 2.7 1.1e-09 37.8 1.3 1.8 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 CDI77143.1 - 1.3e-09 37.9 7.0 5.7e-06 25.9 5.3 2.9 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 CDI77143.1 - 1.5e-05 24.6 2.4 0.00015 21.3 2.4 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein NanE PF04131.14 CDI77143.1 - 0.0017 17.5 1.7 0.23 10.6 1.7 2.8 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.14 CDI77143.1 - 0.0023 17.3 1.1 0.0045 16.3 1.1 1.5 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 CDI77143.1 - 0.0076 15.6 1.3 0.033 13.5 0.9 2.2 2 0 0 2 2 2 1 Thiamine monophosphate synthase DUF561 PF04481.12 CDI77143.1 - 0.032 13.4 0.8 0.36 10.0 0.5 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF561) G3P_antiterm PF04309.12 CDI77143.1 - 0.047 13.1 0.7 0.93 8.9 0.1 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator IGPS PF00218.21 CDI77143.1 - 0.13 11.4 0.1 3.2 6.8 0.0 2.4 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase NAD_binding_7 PF13241.6 CDI77143.1 - 0.16 12.4 0.7 16 6.0 0.1 2.5 1 1 1 2 2 2 0 Putative NAD(P)-binding CTP_transf_like PF01467.26 CDI77147.1 - 0.0047 17.1 0.0 0.031 14.5 0.0 2.4 3 0 0 3 3 3 1 Cytidylyltransferase-like FAD_syn PF06574.12 CDI77147.1 - 0.076 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 FAD synthetase FlgN PF05130.12 CDI77147.1 - 3.1 8.3 6.5 6 7.4 1.4 2.7 2 0 0 2 2 2 0 FlgN protein NTP_transf_3 PF12804.7 CDI77148.1 - 6.2e-13 49.4 0.0 1.4e-12 48.2 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDI77148.1 - 2e-11 44.0 0.0 3.3e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 CDI77148.1 - 0.00038 19.5 0.1 0.00059 18.9 0.1 1.3 1 0 0 1 1 1 1 L-fucokinase Hexapep PF00132.24 CDI77148.1 - 0.0028 17.3 0.1 0.072 12.8 0.1 2.6 1 1 2 3 3 3 1 Bacterial transferase hexapeptide (six repeats) CTP_transf_3 PF02348.19 CDI77148.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase TPR_14 PF13428.6 CDI77149.1 - 0.0083 16.9 1.7 0.0083 16.9 1.7 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI77149.1 - 0.014 15.5 0.3 0.052 13.7 0.3 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat GMC_oxred_N PF00732.19 CDI77149.1 - 0.23 10.8 3.9 0.38 10.1 3.9 1.2 1 0 0 1 1 1 0 GMC oxidoreductase LRR_4 PF12799.7 CDI77151.1 - 1.2e-15 57.4 13.3 2.2e-06 27.9 0.7 5.3 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI77151.1 - 2.1e-14 53.0 12.3 8.8e-06 25.4 0.5 5.2 4 1 1 5 5 5 4 Leucine rich repeat LRR_9 PF14580.6 CDI77151.1 - 1.5e-07 31.1 1.8 0.00046 19.7 0.4 2.4 1 1 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 CDI77151.1 - 8.3e-05 22.3 8.8 0.64 10.2 0.0 6.4 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.33 CDI77151.1 - 0.21 12.2 13.7 5.4 8.0 0.1 6.2 6 2 0 6 6 6 0 Leucine Rich Repeat MSC PF09402.10 CDI77152.1 - 8.7e-12 45.1 3.2 8.7e-12 45.1 3.2 1.3 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain Guanylate_cyc PF00211.20 CDI77153.1 - 2e-17 63.4 1.1 4.9e-17 62.2 0.2 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.31 CDI77153.1 - 1.9e-06 27.3 5.6 1.9e-06 27.3 5.6 1.8 2 0 0 2 2 2 1 Ion transport protein PSII PF00421.19 CDI77153.1 - 0.019 13.6 1.2 0.04 12.6 1.2 1.5 1 0 0 1 1 1 0 Photosystem II protein DUF1635 PF07795.11 CDI77155.1 - 0.0044 16.9 5.5 0.0044 16.9 5.5 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF1635) zinc_ribbon_2 PF13240.6 CDI77157.1 - 0.58 10.0 4.6 3 7.7 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Neisseria_TspB PF05616.13 CDI77157.1 - 1.5 7.2 8.9 0.1 11.1 2.7 1.9 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein TFIIA PF03153.13 CDI77157.1 - 4.9 7.0 40.6 0.054 13.5 17.6 2.5 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ank_4 PF13637.6 CDI77159.1 - 1.5e-09 38.2 0.1 5.8e-08 33.1 0.1 2.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI77159.1 - 6e-09 36.4 0.0 9.8e-09 35.7 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI77159.1 - 2e-08 33.8 0.1 0.033 14.7 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CDI77159.1 - 5.9e-08 32.8 0.0 5.3e-05 23.4 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CDI77159.1 - 4e-07 30.2 0.2 0.0053 17.1 0.5 3.2 3 0 0 3 3 3 2 Ankyrin repeat SAE2 PF08573.10 CDI77161.1 - 6.2e-08 33.7 9.0 6.2e-08 33.7 9.0 7.7 6 2 4 10 10 10 1 DNA repair protein endonuclease SAE2/CtIP C-terminus AP2 PF00847.20 CDI77162.1 - 5.8e-10 39.2 0.3 4.4e-09 36.4 0.3 2.7 1 0 0 1 1 1 1 AP2 domain MtN3_slv PF03083.16 CDI77163.1 - 9e-33 112.2 8.0 2.9e-18 65.7 0.6 2.4 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 CDI77163.1 - 0.00071 19.6 0.4 1.4 9.0 0.0 2.6 2 0 0 2 2 2 2 Lipid A Biosynthesis N-terminal domain SUIM_assoc PF16619.5 CDI77163.1 - 0.033 14.3 4.7 0.096 12.8 4.7 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI77163.1 - 0.11 12.5 26.9 0.15 12.0 26.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI77163.1 - 0.21 11.2 11.3 0.37 10.4 11.3 1.4 1 0 0 1 1 1 0 Spt20 family Phostensin_N PF13916.6 CDI77163.1 - 4.3 7.7 9.6 0.35 11.2 4.1 2.1 1 1 1 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DUF966 PF06136.13 CDI77163.1 - 9.1 5.9 12.5 19 4.9 12.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF966) zf-HC5HC2H_2 PF13832.6 CDI77165.1 - 4e-07 30.2 20.4 1.3e-06 28.6 18.8 6.4 6 1 0 6 6 6 2 PHD-zinc-finger like domain PHD_2 PF13831.6 CDI77165.1 - 4.7e-07 29.3 16.8 3.7e-05 23.2 1.0 3.9 4 0 0 4 4 4 2 PHD-finger PHD PF00628.29 CDI77165.1 - 4.6e-05 23.2 9.4 4.6e-05 23.2 9.4 4.9 4 0 0 4 4 4 2 PHD-finger CPSF100_C PF13299.6 CDI77165.1 - 0.069 13.3 0.1 0.069 13.3 0.1 13.1 11 4 2 15 15 15 0 Cleavage and polyadenylation factor 2 C-terminal TUDOR_5 PF18359.1 CDI77165.1 - 0.12 12.1 0.5 0.26 11.0 0.5 1.5 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain 1 DUF4834 PF16118.5 CDI77166.1 - 0.013 16.4 1.2 0.013 16.4 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI77166.1 - 0.021 14.9 18.7 0.023 14.7 18.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 CDI77166.1 - 0.14 11.5 2.8 0.14 11.5 2.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Folate_carrier PF01770.18 CDI77166.1 - 0.36 9.5 1.0 0.4 9.4 1.0 1.2 1 0 0 1 1 1 0 Reduced folate carrier Lin-8 PF03353.15 CDI77166.1 - 0.88 9.1 14.6 1.1 8.8 14.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI77166.1 - 1 8.1 13.2 1.2 7.9 13.2 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Myosin_head PF00063.21 CDI77167.1 - 1.4e-173 578.8 0.0 1.9e-173 578.3 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Dynein_light PF01221.18 CDI77167.1 - 0.0024 18.1 0.0 0.0092 16.3 0.0 2.0 1 0 0 1 1 1 1 Dynein light chain type 1 AAA_16 PF13191.6 CDI77167.1 - 0.017 15.5 2.7 0.093 13.1 0.0 3.0 4 0 0 4 4 4 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDI77167.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase TRF PF08558.10 CDI77167.1 - 0.97 9.0 5.3 5.8 6.4 0.0 2.9 3 0 0 3 3 3 0 Telomere repeat binding factor (TRF) FTZ PF03867.14 CDI77168.1 - 3.8 7.0 11.6 1.4 8.4 1.3 2.7 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Gal4_dimer PF03902.13 CDI77170.1 - 0.033 14.4 0.8 0.086 13.0 0.8 1.8 1 0 0 1 1 1 0 Gal4-like dimerisation domain Tnp_22_trimer PF17489.2 CDI77170.1 - 0.092 12.7 0.3 0.19 11.8 0.3 1.5 1 0 0 1 1 1 0 L1 transposable element trimerization domain GshA PF08886.11 CDI77170.1 - 0.1 11.2 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase SICA_alpha PF12887.7 CDI77173.1 - 0.012 15.5 0.0 0.045 13.6 0.0 2.0 1 0 0 1 1 1 0 SICA extracellular alpha domain POX PF07526.11 CDI77174.1 - 2.1 8.9 5.0 0.88 10.1 1.8 2.1 1 1 1 2 2 2 0 Associated with HOX Spt20 PF12090.8 CDI77177.1 - 0.007 16.0 10.1 0.007 16.0 10.1 4.7 4 1 1 5 5 5 1 Spt20 family Methyltransf_32 PF13679.6 CDI77177.1 - 0.2 11.6 0.0 0.2 11.6 0.0 4.0 3 1 1 4 4 4 0 Methyltransferase domain PCI PF01399.27 CDI77178.1 - 4.8e-09 36.7 0.0 1.2e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 PCI domain SUIM_assoc PF16619.5 CDI77178.1 - 0.0002 21.3 7.3 0.00064 19.7 0.5 2.6 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 SAC3_GANP PF03399.16 CDI77178.1 - 0.00069 19.1 0.2 0.0013 18.2 0.2 1.3 1 0 0 1 1 1 1 SAC3/GANP family TPR_2 PF07719.17 CDI77178.1 - 0.11 12.7 3.2 1.7 8.9 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat UNC80 PF15778.5 CDI77178.1 - 0.21 11.2 1.7 1.2 8.7 0.9 2.2 2 0 0 2 2 2 0 Cation channel complex component UNC80 TPR_7 PF13176.6 CDI77178.1 - 0.22 11.6 4.9 20 5.5 0.4 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TFIIA PF03153.13 CDI77178.1 - 1.7 8.6 12.3 1.9 8.4 5.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RVP_2 PF08284.11 CDI77180.1 - 4.4e-08 33.0 0.0 6.4e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI77180.1 - 1.8e-05 25.2 0.0 6.2e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI77180.1 - 0.00071 20.1 0.0 0.0015 19.0 0.0 1.7 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Pam16 PF03656.13 CDI77180.1 - 0.12 12.4 0.0 0.95 9.5 0.0 2.0 2 0 0 2 2 2 0 Pam16 SR-25 PF10500.9 CDI77181.1 - 0.0052 16.4 26.0 0.0052 16.4 26.0 4.5 3 2 1 4 4 4 1 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 CDI77181.1 - 1.7 7.1 41.3 0.16 10.5 6.0 2.1 2 0 0 2 2 2 0 Utp14 protein Hamartin PF04388.12 CDI77181.1 - 1.9 7.0 39.9 0.043 12.5 6.2 2.3 2 0 0 2 2 2 0 Hamartin protein AAA_23 PF13476.6 CDI77181.1 - 9.2 6.7 27.2 1.5 9.3 9.8 2.3 2 0 0 2 2 2 0 AAA domain DUF4175 PF13779.6 CDI77181.1 - 9.2 4.0 52.4 0.0067 14.4 14.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) IF4E PF01652.18 CDI77182.1 - 0.14 12.0 0.9 0.75 9.6 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic initiation factor 4E DUF155 PF02582.14 CDI77184.1 - 3.5e-11 43.5 0.0 5.2e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Tic110 PF16940.5 CDI77184.1 - 2.6 6.4 16.0 3.7 5.9 16.0 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Pkinase PF00069.25 CDI77186.1 - 4.7e-30 104.8 0.0 1e-29 103.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77186.1 - 3.2e-11 43.0 0.0 5.5e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TFIIA PF03153.13 CDI77186.1 - 0.00093 19.3 17.5 0.0012 18.9 17.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pkinase_fungal PF17667.1 CDI77186.1 - 0.34 9.6 0.0 0.34 9.6 0.0 2.4 2 1 0 2 2 2 0 Fungal protein kinase DUF4048 PF13257.6 CDI77186.1 - 4.3 7.1 18.2 1.2 8.9 4.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4048) BAF1_ABF1 PF04684.13 CDI77186.1 - 6.5 5.7 16.8 0.98 8.4 3.0 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor CCSAP PF15748.5 CDI77187.1 - 0.0051 17.0 10.1 0.0051 17.0 10.1 2.1 1 1 1 2 2 2 1 Centriole, cilia and spindle-associated ANAPC_CDC26 PF10471.9 CDI77187.1 - 0.03 15.1 36.3 0.62 10.9 13.8 4.2 4 0 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 SR-25 PF10500.9 CDI77187.1 - 1 8.9 25.5 4.6 6.8 4.9 2.5 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Peroxin-13_N PF04088.13 CDI77187.1 - 4.5 7.5 6.7 1.3 9.3 0.9 2.7 3 0 0 3 3 3 0 Peroxin 13, N-terminal region DivIC PF04977.15 CDI77187.1 - 8.9 6.2 21.2 5.2 6.9 8.5 3.1 3 0 0 3 3 3 0 Septum formation initiator CLN3 PF02487.17 CDI77187.1 - 9.8 5.1 6.9 1.9 7.4 2.9 1.7 2 0 0 2 2 2 0 CLN3 protein AAA_23 PF13476.6 CDI77188.1 - 0.062 13.8 0.0 0.062 13.8 0.0 17.9 10 5 3 13 13 13 0 AAA domain Syntaxin-6_N PF09177.11 CDI77189.1 - 0.0021 18.6 2.5 0.0021 18.6 2.5 2.8 3 0 0 3 3 3 1 Syntaxin 6, N-terminal Ribosomal_60s PF00428.19 CDI77189.1 - 0.016 15.7 3.6 0.016 15.7 3.6 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Synaptobrevin PF00957.21 CDI77189.1 - 0.24 11.2 0.1 0.24 11.2 0.1 2.1 2 0 0 2 2 2 0 Synaptobrevin CorA PF01544.18 CDI77189.1 - 0.75 9.0 11.0 0.53 9.6 5.6 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.12 CDI77189.1 - 1 9.4 13.0 0.14 12.2 2.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Cytochrom_B562 PF07361.11 CDI77189.1 - 1.8 9.3 15.1 0.27 11.9 0.5 3.4 3 1 0 3 3 3 0 Cytochrome b562 DUF16 PF01519.16 CDI77189.1 - 7 7.2 20.5 1.2 9.7 2.2 3.2 2 1 1 3 3 3 0 Protein of unknown function DUF16 Pkinase PF00069.25 CDI77191.1 - 4.1e-67 226.3 0.0 5e-67 226.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77191.1 - 7.3e-40 136.9 0.1 1.2e-39 136.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 CDI77191.1 - 8.5e-17 61.4 0.2 3.4e-07 30.6 0.0 3.9 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI77191.1 - 6.3e-16 56.7 1.0 6.1e-06 25.4 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 CDI77191.1 - 2.1e-14 53.1 0.5 4.8e-06 26.3 0.1 4.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI77191.1 - 3.4e-14 51.5 1.8 0.00013 21.6 0.1 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDI77191.1 - 6.1e-12 44.5 0.8 4.8e-05 22.7 0.1 4.3 4 0 0 4 4 4 2 EF hand Kdo PF06293.14 CDI77191.1 - 1.4e-06 27.8 0.0 2.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDI77191.1 - 3.7e-06 26.5 0.0 5.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDI77191.1 - 0.0012 18.8 0.0 0.2 11.6 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDI77191.1 - 0.051 13.2 0.1 0.093 12.3 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF789 PF05623.12 CDI77192.1 - 9.8e-31 107.5 0.0 9.8e-31 107.5 0.0 8.2 7 3 0 7 7 7 1 Protein of unknown function (DUF789) Pex14_N PF04695.13 CDI77193.1 - 3.1e-05 24.7 6.0 5.3e-05 23.9 6.0 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region ANXA2R PF15721.5 CDI77193.1 - 0.0014 19.2 6.6 0.0031 18.1 6.6 1.5 1 0 0 1 1 1 1 Annexin-2 receptor Hid1 PF12722.7 CDI77193.1 - 0.0031 15.7 3.4 0.0034 15.6 3.4 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Spt20 PF12090.8 CDI77193.1 - 0.0031 17.2 20.2 0.0048 16.6 20.2 1.2 1 0 0 1 1 1 1 Spt20 family Lin-8 PF03353.15 CDI77193.1 - 0.0078 15.8 10.9 0.012 15.2 10.9 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI77193.1 - 0.011 14.1 8.2 0.013 13.8 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI77193.1 - 0.02 13.7 10.3 0.026 13.3 10.3 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 CDI77193.1 - 0.021 14.4 1.4 0.033 13.7 1.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Plasmodium_Vir PF05795.11 CDI77193.1 - 0.028 13.9 3.1 0.039 13.4 3.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TMEM52 PF14979.6 CDI77193.1 - 0.083 12.8 1.3 0.095 12.6 0.0 1.7 2 0 0 2 2 1 0 Transmembrane 52 Tim54 PF11711.8 CDI77193.1 - 0.093 11.5 6.3 0.14 10.9 6.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2722 PF10846.8 CDI77193.1 - 0.15 11.0 17.5 0.22 10.4 17.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Connexin PF00029.19 CDI77193.1 - 0.15 11.8 1.8 0.22 11.2 1.8 1.3 1 0 0 1 1 1 0 Connexin OATP PF03137.20 CDI77193.1 - 0.19 10.0 0.6 0.26 9.5 0.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SprA-related PF12118.8 CDI77193.1 - 0.21 10.7 21.4 0.31 10.1 21.4 1.1 1 0 0 1 1 1 0 SprA-related family TFIIA PF03153.13 CDI77193.1 - 0.23 11.4 21.1 0.35 10.8 21.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI77193.1 - 0.25 10.5 2.8 0.44 9.7 2.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CCSAP PF15748.5 CDI77193.1 - 0.35 11.0 17.9 0.14 12.4 15.4 1.5 2 0 0 2 2 1 0 Centriole, cilia and spindle-associated RNA_pol_Rbc25 PF08292.12 CDI77193.1 - 0.43 10.8 6.4 0.95 9.7 6.4 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Roughex PF06020.11 CDI77193.1 - 0.49 9.4 18.7 0.86 8.6 18.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Paf1 PF03985.13 CDI77193.1 - 0.57 9.1 15.8 0.73 8.8 15.8 1.2 1 0 0 1 1 1 0 Paf1 Ndc1_Nup PF09531.10 CDI77193.1 - 0.61 8.7 3.6 0.81 8.3 3.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Band_3_cyto PF07565.13 CDI77193.1 - 0.65 9.8 7.5 0.96 9.2 7.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Peptidase_S64 PF08192.11 CDI77193.1 - 0.78 8.2 6.5 0.96 7.9 6.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Suf PF05843.14 CDI77193.1 - 1.1 9.2 8.5 1.4 8.8 8.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CPSF100_C PF13299.6 CDI77193.1 - 1.3 9.2 10.6 2.3 8.4 10.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI77193.1 - 1.4 7.8 11.0 1.9 7.4 11.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI77193.1 - 1.6 8.7 7.4 3 7.9 7.4 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.12 CDI77193.1 - 1.7 7.5 6.7 2.3 7.1 6.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GREB1 PF15782.5 CDI77193.1 - 1.8 5.6 6.6 2.2 5.3 6.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Coilin_N PF15862.5 CDI77193.1 - 1.9 8.3 13.5 3.2 7.5 13.5 1.4 1 0 0 1 1 1 0 Coilin N-terminus SLC12 PF03522.15 CDI77193.1 - 2.5 7.0 11.7 3.6 6.5 11.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 CDI77193.1 - 2.7 6.7 10.2 3.4 6.3 10.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein EphA2_TM PF14575.6 CDI77193.1 - 2.8 8.9 4.2 53 4.8 0.0 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TERB2 PF15101.6 CDI77193.1 - 2.9 7.9 11.7 4.3 7.3 11.7 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TP53IP5 PF15331.6 CDI77193.1 - 3.2 7.8 8.0 5.3 7.1 8.0 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4834 PF16118.5 CDI77193.1 - 3.7 8.6 10.7 8.6 7.4 10.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PBP_sp32 PF07222.12 CDI77193.1 - 4.4 6.7 16.7 7.5 5.9 16.7 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4407 PF14362.6 CDI77193.1 - 5.2 6.3 8.4 7.3 5.9 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Gti1_Pac2 PF09729.9 CDI77193.1 - 5.2 7.1 9.4 12 5.9 9.4 1.6 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3292 PF11696.8 CDI77193.1 - 5.3 5.3 7.8 7.1 4.9 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) FAM60A PF15396.6 CDI77193.1 - 8 6.4 7.8 12 5.8 7.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI77193.1 - 8.3 6.1 14.8 13 5.5 14.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Androgen_recep PF02166.16 CDI77193.1 - 9 5.0 21.4 14 4.4 21.4 1.3 1 0 0 1 1 1 0 Androgen receptor SR-25 PF10500.9 CDI77194.1 - 0.017 14.8 9.2 0.022 14.4 9.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI77194.1 - 0.073 13.7 9.5 0.11 13.1 7.9 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3446 PF11928.8 CDI77194.1 - 0.44 10.9 12.3 0.57 10.5 6.8 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Herpes_pp85 PF04637.12 CDI77194.1 - 0.79 8.1 2.3 1.1 7.6 2.3 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Chorion_2 PF03964.15 CDI77194.1 - 5.1 8.0 18.4 1.4 9.8 4.8 2.2 1 1 1 2 2 2 0 Chorion family 2 WD40 PF00400.32 CDI77195.1 - 0.0027 18.5 5.9 0.6 11.1 5.9 3.0 1 1 0 1 1 1 1 WD domain, G-beta repeat DUF2722 PF10846.8 CDI77195.1 - 0.0058 15.6 7.3 0.0058 15.6 7.3 3.3 3 1 0 3 3 2 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI77195.1 - 0.0078 16.5 6.3 0.0078 16.5 6.3 4.4 2 2 2 4 4 2 1 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI77195.1 - 0.017 14.1 33.0 0.014 14.4 13.2 2.5 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Ribosomal_60s PF00428.19 CDI77195.1 - 0.021 15.4 3.4 0.021 15.4 3.4 4.6 3 1 1 4 4 3 0 60s Acidic ribosomal protein RNase_H2_suC PF08615.11 CDI77195.1 - 0.047 13.9 0.5 4.1 7.6 0.2 2.4 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) CDV3 PF15359.6 CDI77195.1 - 0.92 10.0 10.3 5.5 7.5 1.5 2.6 2 1 0 2 2 2 0 Carnitine deficiency-associated protein 3 EphA2_TM PF14575.6 CDI77195.1 - 1 10.3 3.3 17 6.4 1.7 2.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Roughex PF06020.11 CDI77195.1 - 2.7 7.0 14.4 0.27 10.3 2.8 2.5 2 0 0 2 2 2 0 Drosophila roughex protein Presenilin PF01080.17 CDI77195.1 - 4.8 5.8 17.2 5.3 5.7 1.4 2.2 2 0 0 2 2 2 0 Presenilin Suf PF05843.14 CDI77195.1 - 8.9 6.2 21.1 0.5 10.3 6.5 2.7 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) EF-hand_13 PF17958.1 CDI77199.1 - 5.3e-11 42.2 0.0 1.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 CDI77199.1 - 4.1e-07 30.4 1.3 0.13 12.7 0.5 3.8 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI77199.1 - 0.00025 20.7 0.2 0.13 12.3 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 CDI77199.1 - 0.021 14.4 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 0 EF hand PKS_DE PF18369.1 CDI77199.1 - 0.53 10.9 4.9 0.84 10.3 0.8 2.5 2 0 0 2 2 2 0 Polyketide synthase dimerisation element domain Hydrolase_3 PF08282.12 CDI77200.1 - 2.8e-30 105.9 0.0 5.7e-19 68.9 0.0 2.0 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDI77200.1 - 2.5e-05 24.7 0.1 0.029 14.6 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDI77200.1 - 0.0041 16.7 0.0 0.47 9.9 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Rsa3 PF14615.6 CDI77201.1 - 0.08 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosome-assembly protein 3 DivIC PF04977.15 CDI77202.1 - 0.56 10.0 9.5 0.089 12.6 3.6 2.3 1 1 1 2 2 2 0 Septum formation initiator Spc7_C2 PF15577.6 CDI77203.1 - 0.025 14.6 0.1 0.053 13.6 0.1 1.5 1 0 0 1 1 1 0 Spc7_C2 ACDC PF14733.6 CDI77207.1 - 7.6e-17 61.4 0.1 7.6e-17 61.4 0.1 2.1 2 0 0 2 2 2 1 AP2-coincident C-terminal AP2 PF00847.20 CDI77207.1 - 1.4e-09 38.0 0.3 1.4e-09 38.0 0.3 2.7 3 0 0 3 3 3 1 AP2 domain APOBEC1 PF18769.1 CDI77209.1 - 0.11 12.7 0.8 0.32 11.3 0.1 2.1 2 0 0 2 2 2 0 APOBEC1 DDHD PF02862.17 CDI77209.1 - 0.93 9.6 9.1 0.14 12.3 0.7 3.2 3 0 0 3 3 3 0 DDHD domain DUF719 PF05334.13 CDI77209.1 - 3.1 7.9 7.0 0.2 11.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF719) AAA_33 PF13671.6 CDI77209.1 - 9.3 6.4 7.4 1.3 9.2 0.3 3.1 2 1 1 3 3 3 0 AAA domain CHD5 PF04420.14 CDI77210.1 - 0.39 10.6 1.3 8.8 6.2 0.0 2.3 2 0 0 2 2 2 0 CHD5-like protein Vps16_C PF04840.12 CDI77212.1 - 1.8e-30 106.1 1.1 6e-29 101.1 1.1 2.4 1 1 0 1 1 1 1 Vps16, C-terminal region DUF2547 PF10818.8 CDI77212.1 - 0.055 14.4 1.7 0.21 12.5 1.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2547) ANTH PF07651.16 CDI77212.1 - 0.11 11.4 0.6 0.55 9.2 0.1 2.1 2 0 0 2 2 2 0 ANTH domain DHR-2 PF06920.13 CDI77212.1 - 0.3 9.7 1.9 0.97 8.0 0.2 2.0 2 0 0 2 2 2 0 Dock homology region 2 Lipase_3 PF01764.25 CDI77214.1 - 3.8e-10 39.8 0.1 7.5e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 CDI77214.1 - 0.0091 15.6 0.1 0.016 14.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) DUF676 PF05057.14 CDI77214.1 - 0.091 12.3 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) SelP_N PF04592.14 CDI77214.1 - 1.5 8.2 12.6 2.4 7.5 12.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Fe-S_biosyn PF01521.20 CDI77215.1 - 1.1e-07 32.1 0.0 0.00013 22.1 0.0 2.6 2 1 0 2 2 2 2 Iron-sulphur cluster biosynthesis DUF4603 PF15376.6 CDI77215.1 - 0.37 8.1 1.5 0.45 7.9 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) NDK PF00334.19 CDI77216.1 - 1.6e-28 99.4 0.0 1.5e-25 89.8 0.0 2.2 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.12 CDI77216.1 - 0.00036 20.3 0.0 0.00066 19.5 0.0 1.4 1 0 0 1 1 1 1 DUF1126 PH-like domain DUF4147 PF13660.6 CDI77216.1 - 0.003 17.1 1.3 0.0049 16.4 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) AAA_5 PF07728.14 CDI77217.1 - 1.9e-94 313.0 0.0 9.9e-13 48.3 0.0 11.8 11 0 0 11 11 11 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CDI77217.1 - 8.5e-28 96.7 6.8 6.9e-12 45.5 0.0 4.8 3 0 0 3 3 3 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 CDI77217.1 - 5.9e-19 68.1 0.0 1.9e-18 66.5 0.0 2.0 1 0 0 1 1 1 1 Midasin AAA lid domain AAA PF00004.29 CDI77217.1 - 6.1e-18 65.5 0.0 0.0094 16.4 0.0 6.5 5 0 0 5 5 5 5 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI77217.1 - 8.3e-14 52.0 1.3 0.083 13.2 0.0 8.2 6 0 0 6 6 6 3 AAA domain AAA_3 PF07726.11 CDI77217.1 - 1.6e-13 50.6 0.0 0.0046 16.8 0.0 7.4 8 0 0 8 8 8 3 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 CDI77217.1 - 5.2e-13 49.1 0.0 0.00023 21.2 0.0 6.5 5 0 0 5 5 5 2 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 CDI77217.1 - 1e-11 44.7 0.0 0.055 13.0 0.0 5.6 5 0 0 5 5 5 3 P-loop containing dynein motor region TsaE PF02367.17 CDI77217.1 - 1e-10 41.7 3.2 0.78 9.8 0.1 6.1 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CDI77217.1 - 1.4e-07 32.2 0.0 0.98 10.0 0.0 7.0 6 0 0 6 6 6 1 AAA domain AAA_33 PF13671.6 CDI77217.1 - 1.4e-07 31.7 28.8 0.0011 19.1 0.6 8.3 7 1 1 8 8 5 3 AAA domain Mg_chelatase PF01078.21 CDI77217.1 - 1.1e-05 25.0 2.6 0.086 12.2 0.0 5.6 6 0 0 6 6 6 1 Magnesium chelatase, subunit ChlI AAA_8 PF12780.7 CDI77217.1 - 2.2e-05 23.9 0.0 0.085 12.2 0.0 4.8 5 0 0 5 5 5 1 P-loop containing dynein motor region D4 RNA_helicase PF00910.22 CDI77217.1 - 2.3e-05 24.8 0.0 20 5.6 0.0 5.4 5 0 0 5 5 5 0 RNA helicase NACHT PF05729.12 CDI77217.1 - 3e-05 24.0 2.5 0.85 9.5 0.0 6.8 5 0 0 5 5 5 1 NACHT domain AAA_6 PF12774.7 CDI77217.1 - 0.00014 20.9 0.0 1.4 7.8 0.0 4.7 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region AAA_16 PF13191.6 CDI77217.1 - 0.00016 22.1 4.7 0.0015 18.9 0.6 18.4 16 7 3 19 19 11 4 AAA ATPase domain RuvB_N PF05496.12 CDI77217.1 - 0.00066 19.5 0.2 18 5.0 0.0 5.4 6 0 0 6 6 6 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 CDI77217.1 - 0.00096 19.1 0.6 3 7.7 0.0 4.5 5 0 0 5 5 5 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 CDI77217.1 - 0.015 15.0 0.0 0.51 10.0 0.0 3.5 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase zf-RING_2 PF13639.6 CDI77218.1 - 2.3e-07 31.0 13.0 2.3e-07 31.0 13.0 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDI77218.1 - 2.5e-06 27.1 5.2 2.5e-06 27.1 5.2 2.3 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI77218.1 - 6.7e-05 22.6 11.6 6.7e-05 22.6 11.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDI77218.1 - 0.00021 21.5 10.0 0.00021 21.5 10.0 3.4 4 0 0 4 4 4 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDI77218.1 - 0.00027 20.9 6.2 0.00027 20.9 6.2 3.3 2 1 1 3 3 3 1 RING-type zinc-finger Eapp_C PF10238.9 CDI77218.1 - 0.01 15.9 4.1 0.01 15.9 4.1 6.7 6 1 1 8 8 8 0 E2F-associated phosphoprotein zf-C3HC4 PF00097.25 CDI77218.1 - 0.012 15.5 12.9 0.012 15.5 12.9 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RSB_motif PF16294.5 CDI77218.1 - 0.018 15.3 4.9 0.018 15.3 4.9 6.4 8 0 0 8 8 8 0 RNSP1-SAP18 binding (RSB) motif SUIM_assoc PF16619.5 CDI77218.1 - 0.23 11.5 0.0 0.23 11.5 0.0 11.4 7 4 2 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 PTR2 PF00854.21 CDI77218.1 - 0.43 9.4 1.3 19 3.9 0.2 2.5 2 0 0 2 2 2 0 POT family SARAF PF06682.12 CDI77219.1 - 0.00027 20.7 14.7 0.0024 17.6 10.8 2.2 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis RCC1 PF00415.18 CDI77219.1 - 0.0007 20.2 0.0 0.0017 19.0 0.0 1.6 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat Zip PF02535.22 CDI77219.1 - 0.018 14.3 1.8 1.6 7.8 0.0 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter DUF908 PF06012.12 CDI77219.1 - 0.02 14.4 3.7 0.049 13.0 3.7 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) ORC_WH_C PF18137.1 CDI77219.1 - 0.025 14.6 4.9 0.066 13.3 4.9 1.7 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Connexin PF00029.19 CDI77219.1 - 0.12 12.2 1.0 0.21 11.3 1.0 1.3 1 0 0 1 1 1 0 Connexin PIP5K PF01504.18 CDI77219.1 - 0.13 11.4 1.3 0.2 10.8 1.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Presenilin PF01080.17 CDI77219.1 - 0.19 10.5 6.1 0.31 9.8 6.1 1.2 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI77219.1 - 0.56 8.1 6.0 0.82 7.5 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI77219.1 - 0.59 8.2 4.0 0.85 7.7 4.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CDI77219.1 - 1.3 9.0 3.2 2.7 8.0 3.2 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DAG_kinase_N PF14513.6 CDI77219.1 - 1.7 8.8 8.9 4.4 7.5 8.9 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus CDC45 PF02724.14 CDI77219.1 - 2.2 6.5 5.7 3.3 5.9 5.7 1.2 1 0 0 1 1 1 0 CDC45-like protein PAT1 PF09770.9 CDI77219.1 - 4.8 5.3 22.4 0.55 8.4 17.6 1.6 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 CDI77219.1 - 5.8 6.6 6.7 9.7 5.9 6.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RED_N PF07808.13 CDI77219.1 - 6.9 6.2 10.9 16 4.9 10.9 1.6 1 0 0 1 1 1 0 RED-like protein N-terminal region SLC12 PF03522.15 CDI77219.1 - 9.4 5.1 7.8 15 4.5 7.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FliD_N PF02465.18 CDI77226.1 - 0.012 16.3 4.2 0.024 15.3 4.2 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus TERB2 PF15101.6 CDI77226.1 - 0.014 15.5 5.9 0.023 14.7 5.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TORC_N PF12884.7 CDI77226.1 - 0.035 14.9 4.4 0.035 14.9 4.4 1.9 2 0 0 2 2 1 0 Transducer of regulated CREB activity, N terminus HECT PF00632.25 CDI77226.1 - 0.035 13.6 2.1 0.055 12.9 2.1 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) DUF2722 PF10846.8 CDI77226.1 - 0.038 13.0 8.3 0.05 12.6 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Het-C PF07217.11 CDI77226.1 - 0.067 11.7 1.8 0.099 11.2 1.8 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Spt20 PF12090.8 CDI77226.1 - 0.15 11.6 14.7 0.062 12.9 11.5 1.8 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI77226.1 - 0.21 11.5 11.9 0.31 11.0 11.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPT16 PF08644.11 CDI77226.1 - 0.32 11.2 5.0 0.7 10.1 5.0 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) PP_kinase_N PF13089.6 CDI77226.1 - 0.69 10.3 12.7 0.18 12.2 0.4 2.5 1 1 1 2 2 2 0 Polyphosphate kinase N-terminal domain GvpL_GvpF PF06386.11 CDI77226.1 - 1.1 9.1 8.8 0.99 9.3 7.2 1.8 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF CTU2 PF10288.9 CDI77226.1 - 1.5 9.1 9.8 2.9 8.2 9.8 1.6 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF4407 PF14362.6 CDI77226.1 - 1.5 8.1 9.0 2.9 7.2 9.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Allexi_40kDa PF05549.11 CDI77226.1 - 3 7.3 6.2 3.4 7.1 4.9 1.7 1 1 0 1 1 1 0 Allexivirus 40kDa protein GN3L_Grn1 PF08701.11 CDI77226.1 - 4.5 7.5 12.4 15 5.8 12.4 1.8 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase DUF4570 PF15134.6 CDI77226.1 - 4.9 7.2 15.5 12 5.9 14.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) PACT_coil_coil PF10495.9 CDI77226.1 - 5.7 7.6 9.1 13 6.5 0.1 2.4 2 0 0 2 2 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein FapA PF03961.13 CDI77226.1 - 7.9 5.0 9.4 10 4.6 9.2 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A baeRF_family10 PF18854.1 CDI77226.1 - 8.8 6.6 10.0 3.5e+02 1.4 10.0 2.4 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 ABC_tran PF00005.27 CDI77227.1 - 2.4e-25 89.6 0.0 9.7e-24 84.4 0.0 2.6 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CDI77227.1 - 3.7e-06 27.0 0.0 0.05 13.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CDI77227.1 - 0.0043 16.6 0.0 0.0088 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI77227.1 - 0.0089 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDI77227.1 - 0.013 16.0 1.4 0.56 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CDI77227.1 - 0.036 14.1 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CDI77227.1 - 0.047 13.0 0.0 0.094 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 CDI77227.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase TFIIA PF03153.13 CDI77227.1 - 6.1 6.7 12.6 1.1 9.2 8.9 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ABC_tran PF00005.27 CDI77228.1 - 2.6e-15 57.1 0.0 1.8e-13 51.2 0.0 3.4 2 1 0 2 2 2 1 ABC transporter TFIIA PF03153.13 CDI77228.1 - 0.00016 21.8 14.8 0.00016 21.8 14.8 4.8 4 2 0 4 4 2 1 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI77228.1 - 0.00017 20.3 1.9 0.00037 19.1 1.9 1.5 1 0 0 1 1 1 1 FHIPEP family AAA_29 PF13555.6 CDI77228.1 - 0.0059 16.3 2.3 0.0093 15.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain Otopetrin PF03189.13 CDI77228.1 - 0.0094 14.8 0.0 0.023 13.6 0.0 1.5 1 1 0 1 1 1 1 Otopetrin Dynamin_N PF00350.23 CDI77228.1 - 0.034 14.2 6.4 0.44 10.6 0.2 2.6 2 0 0 2 2 2 0 Dynamin family RsgA_GTPase PF03193.16 CDI77228.1 - 0.049 13.5 0.0 0.049 13.5 0.0 1.7 2 0 0 2 2 1 0 RsgA GTPase Connexin PF00029.19 CDI77228.1 - 0.23 11.2 2.4 0.16 11.7 0.3 1.8 2 0 0 2 2 2 0 Connexin AAA_23 PF13476.6 CDI77228.1 - 0.32 11.5 13.1 11 6.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 CDI77228.1 - 0.37 10.4 5.0 1 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain FAM176 PF14851.6 CDI77228.1 - 7.9 6.1 8.9 4.2 7.0 4.2 2.7 2 0 0 2 2 2 0 FAM176 family HNOBA PF07701.14 CDI77228.1 - 9.6 5.6 10.8 25 4.2 8.6 2.2 2 0 0 2 2 2 0 Heme NO binding associated Aldo_ket_red PF00248.21 CDI77229.1 - 2.7e-09 36.7 1.3 6.4e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 Aldo/keto reductase family DDHD PF02862.17 CDI77229.1 - 0.00049 20.3 2.6 0.00049 20.3 2.6 2.2 2 0 0 2 2 2 1 DDHD domain SpoIIP PF07454.11 CDI77229.1 - 0.0059 16.1 10.4 0.0059 16.1 10.4 1.8 2 0 0 2 2 2 1 Stage II sporulation protein P (SpoIIP) EPL1 PF10513.9 CDI77229.1 - 0.0065 16.9 7.4 0.0065 16.9 7.4 2.5 3 0 0 3 3 3 1 Enhancer of polycomb-like Otopetrin PF03189.13 CDI77229.1 - 0.1 11.4 1.8 0.16 10.7 1.8 1.2 1 0 0 1 1 1 0 Otopetrin UPF0565 PF10561.9 CDI77229.1 - 0.18 11.0 5.4 0.069 12.3 0.6 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Velvet PF11754.8 CDI77229.1 - 0.23 11.3 15.9 0.038 13.9 9.1 2.3 2 0 0 2 2 2 0 Velvet factor DUF2347 PF09804.9 CDI77229.1 - 0.29 10.7 7.5 0.52 9.9 7.5 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Cellulose_synt PF03552.14 CDI77229.1 - 0.7 8.3 1.3 1.1 7.7 1.3 1.2 1 0 0 1 1 1 0 Cellulose synthase DUF3408 PF11888.8 CDI77229.1 - 0.72 10.0 13.8 2.4 8.3 13.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Zip PF02535.22 CDI77229.1 - 1.1 8.4 4.4 2.1 7.5 4.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter eIF-3_zeta PF05091.12 CDI77229.1 - 4.4 6.2 25.9 0.85 8.5 19.3 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FancD2 PF14631.6 CDI77229.1 - 7.2 3.9 11.4 10 3.4 11.4 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RskA PF10099.9 CDI77231.1 - 0.0027 18.0 10.9 0.0027 18.0 10.9 15.3 4 3 4 9 9 9 2 Anti-sigma-K factor rskA SPX PF03105.19 CDI77231.1 - 0.0052 16.8 1.6 0.0052 16.8 1.6 5.6 5 1 0 5 5 5 2 SPX domain TAN PF11640.8 CDI77231.1 - 0.11 12.6 2.7 2 8.6 0.1 3.0 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair SPX PF03105.19 CDI77232.1 - 0.053 13.4 25.7 0.42 10.5 5.7 2.5 2 0 0 2 2 2 0 SPX domain Lin-8 PF03353.15 CDI77232.1 - 0.46 10.0 29.3 0.14 11.7 13.3 2.6 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist Raftlin PF15250.6 CDI77232.1 - 2.3 6.9 15.1 0.43 9.3 6.1 2.4 2 0 0 2 2 2 0 Raftlin GAGA_bind PF06217.12 CDI77232.1 - 3 8.0 14.5 2.2 8.5 9.4 2.7 3 0 0 3 3 3 0 GAGA binding protein-like family Abhydrolase_1 PF00561.20 CDI77232.1 - 8.9 5.9 10.8 5 6.7 0.0 3.4 3 0 0 3 3 3 0 alpha/beta hydrolase fold SUIM_assoc PF16619.5 CDI77233.1 - 0.0075 16.3 0.8 0.0075 16.3 0.8 2.7 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L12_N PF16320.5 CDI77233.1 - 0.035 13.8 0.2 0.035 13.8 0.2 3.3 2 1 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain ADK_lid PF05191.14 CDI77233.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Adenylate kinase, active site lid TFIIA PF03153.13 CDI77233.1 - 2.1 8.2 23.5 3.3 7.6 8.0 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI77233.1 - 6.7 6.3 25.8 0.45 10.1 6.2 2.1 2 0 0 2 2 2 0 Spt20 family DUF4667 PF15700.5 CDI77234.1 - 0.0057 16.8 1.5 0.0057 16.8 1.5 7.0 3 2 2 5 5 5 1 Domain of unknown function (DUF4667) UTP25 PF06862.12 CDI77235.1 - 1.3e-35 123.1 5.8 1.2e-30 106.8 2.0 2.5 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Activator_LAG-3 PF11498.8 CDI77237.1 - 1.3e-05 24.3 2.6 1.3e-05 24.3 2.6 4.0 4 0 0 4 4 4 2 Transcriptional activator LAG-3 PPP4R2 PF09184.11 CDI77237.1 - 1.6 8.2 15.5 1.1 8.8 3.7 2.8 2 0 0 2 2 2 0 PPP4R2 Dynein_light PF01221.18 CDI77240.1 - 1.7e-39 134.0 0.4 1.7e-39 134.0 0.4 1.8 2 0 0 2 2 2 1 Dynein light chain type 1 MBF1 PF08523.10 CDI77241.1 - 2.6e-19 69.5 1.9 2.6e-19 69.5 1.9 1.8 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 CDI77241.1 - 8.8e-15 54.5 0.2 1.4e-14 53.8 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDI77241.1 - 5.9e-08 32.9 0.0 1.1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDI77241.1 - 1.7e-07 31.2 0.0 3.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDI77241.1 - 0.0041 17.5 0.0 0.0081 16.6 0.0 1.4 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_38 PF13936.6 CDI77241.1 - 0.0076 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CDI77241.1 - 0.013 15.4 0.2 0.038 13.9 0.1 1.8 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_25 PF13413.6 CDI77241.1 - 0.033 14.1 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain LCD1 PF09798.9 CDI77241.1 - 0.11 11.0 0.3 0.1 11.1 0.3 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein HTH_24 PF13412.6 CDI77241.1 - 0.14 11.8 0.0 0.31 10.6 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding UPF0203 PF05254.12 CDI77242.1 - 0.00093 19.4 2.2 0.0014 18.9 2.2 1.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX6B PF02297.17 CDI77242.1 - 0.0072 16.5 2.3 0.0091 16.2 2.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb UCR_hinge PF02320.16 CDI77242.1 - 0.3 11.3 8.2 0.43 10.8 1.8 2.1 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Transketolase_N PF00456.21 CDI77243.1 - 4e-125 417.2 0.4 4.4e-91 305.3 0.0 2.3 2 0 0 2 2 2 2 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CDI77243.1 - 1.4e-37 129.1 0.0 2.3e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDI77243.1 - 0.00053 19.9 0.0 0.0014 18.5 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CDI77243.1 - 0.0074 15.5 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase ACDC PF14733.6 CDI77244.1 - 1.8e-21 76.3 1.3 3.2e-21 75.5 1.3 1.4 1 0 0 1 1 1 1 AP2-coincident C-terminal Dicty_REP PF05086.12 CDI77244.1 - 0.11 10.5 0.0 0.14 10.1 0.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Clathrin_propel PF01394.20 CDI77244.1 - 0.21 12.0 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Clathrin propeller repeat Ribosomal_S17 PF00366.20 CDI77245.1 - 3.6e-13 49.4 0.1 5.7e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 His_Phos_1 PF00300.22 CDI77246.1 - 7.4e-43 146.5 3.3 6.9e-29 100.9 0.1 2.4 2 1 1 3 3 3 2 Histidine phosphatase superfamily (branch 1) Med3 PF11593.8 CDI77246.1 - 0.02 14.1 1.3 0.025 13.8 1.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Adeno_PV PF03910.13 CDI77246.1 - 0.33 9.6 3.3 0.47 9.1 3.3 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Ribosomal_S17e PF00833.18 CDI77247.1 - 5.3e-60 200.7 1.8 6e-60 200.5 1.8 1.0 1 0 0 1 1 1 1 Ribosomal S17 SpoIIE PF07228.12 CDI77248.1 - 3.4e-11 43.4 4.2 0.0084 16.0 0.1 4.0 3 0 0 3 3 3 3 Stage II sporulation protein E (SpoIIE) Rad60-SLD PF11976.8 CDI77249.1 - 3.1e-23 81.4 0.0 3.8e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDI77249.1 - 1.9e-10 40.3 0.0 2.4e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family UBX PF00789.20 CDI77249.1 - 0.13 12.5 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 UBX domain zf-CSL PF05207.13 CDI77250.1 - 2.2e-07 30.5 0.0 5.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 CSL zinc finger RMI1_N PF08585.12 CDI77250.1 - 9.6e-05 22.2 3.0 9.6e-05 22.2 3.0 2.1 2 1 1 3 3 3 1 RecQ mediated genome instability protein Adaptin_binding PF10199.9 CDI77250.1 - 0.57 10.8 7.5 2.8 8.6 3.9 3.0 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 SUIM_assoc PF16619.5 CDI77250.1 - 6.3 6.9 24.6 0.46 10.6 6.5 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 V-ATPase_G PF03179.15 CDI77252.1 - 1.4e-24 86.6 8.2 1.6e-24 86.4 8.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit HrpE PF06188.12 CDI77252.1 - 0.076 12.9 2.4 0.15 11.9 2.4 1.4 1 1 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E ATP-synt_B PF00430.18 CDI77252.1 - 0.079 13.0 10.5 0.066 13.3 9.1 1.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) PEP-utilisers_N PF05524.13 CDI77252.1 - 0.58 10.3 5.6 0.85 9.8 5.6 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal WD40 PF00400.32 CDI77254.1 - 1.8e-09 38.0 7.6 0.051 14.5 0.1 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_4 PF16300.5 CDI77256.1 - 5.3e-19 67.8 0.0 1e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 CDI77256.1 - 6.1e-10 39.5 0.2 1e-06 29.4 0.0 3.5 3 0 0 3 3 2 1 WD domain, G-beta repeat DUF1899 PF08953.11 CDI77256.1 - 1.3e-06 28.2 0.0 2.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) DUF812 PF05667.11 CDI77256.1 - 0.00038 19.5 12.3 0.00051 19.1 12.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Shugoshin_N PF07558.11 CDI77256.1 - 0.0065 16.3 5.1 0.1 12.5 0.5 3.1 1 1 1 2 2 2 1 Shugoshin N-terminal coiled-coil region ANAPC4_WD40 PF12894.7 CDI77256.1 - 0.0069 16.7 0.0 9.1 6.7 0.0 3.9 3 1 1 4 4 3 0 Anaphase-promoting complex subunit 4 WD40 domain Baculo_PEP_C PF04513.12 CDI77256.1 - 0.017 15.2 5.6 0.037 14.1 4.7 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.9 CDI77256.1 - 0.022 15.1 17.2 0.67 10.3 5.6 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Exonuc_VII_L PF02601.15 CDI77256.1 - 0.047 13.3 6.5 0.069 12.7 6.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TolA_bind_tri PF16331.5 CDI77256.1 - 0.047 13.8 18.8 0.71 10.0 2.0 2.8 1 1 1 3 3 3 0 TolA binding protein trimerisation ABC_tran_CTD PF16326.5 CDI77256.1 - 0.097 12.9 26.8 0.19 12.0 11.9 4.1 1 1 3 4 4 4 0 ABC transporter C-terminal domain DUF4407 PF14362.6 CDI77256.1 - 0.14 11.5 13.0 0.25 10.6 13.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pkip-1 PF06878.11 CDI77256.1 - 0.15 12.2 7.6 0.33 11.1 2.2 2.7 3 0 0 3 3 3 0 Pkip-1 protein Phage_GP20 PF06810.11 CDI77256.1 - 0.17 11.7 19.1 0.74 9.6 16.8 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 Ge1_WD40 PF16529.5 CDI77256.1 - 0.18 10.8 0.0 1.8 7.4 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Jnk-SapK_ap_N PF09744.9 CDI77256.1 - 0.2 11.9 25.2 0.42 10.8 5.1 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Atg14 PF10186.9 CDI77256.1 - 0.21 10.6 16.3 0.31 10.1 16.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Leu_zip PF15294.6 CDI77256.1 - 0.33 10.4 18.2 1.6 8.2 18.0 1.8 1 1 1 2 2 2 0 Leucine zipper V_ATPase_I PF01496.19 CDI77256.1 - 0.47 8.3 10.1 0.64 7.9 10.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.7 CDI77256.1 - 0.58 10.3 26.9 2.1 8.5 17.2 2.2 1 1 1 2 2 2 0 Tropomyosin like DUF4140 PF13600.6 CDI77256.1 - 1.1 9.7 19.1 0.29 11.6 9.0 2.8 2 1 1 3 3 1 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.10 CDI77256.1 - 1.9 8.6 13.3 0.88 9.7 6.8 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RPW8 PF05659.11 CDI77256.1 - 2.5 7.8 7.9 4.5 7.0 1.9 2.3 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Lebercilin PF15619.6 CDI77256.1 - 2.9 7.5 25.5 8.2 6.0 25.5 1.7 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.12 CDI77256.1 - 3.8 7.6 27.9 11 6.0 17.0 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein MCC-bdg_PDZ PF10506.9 CDI77256.1 - 4.8 7.3 12.1 7.1 6.7 1.5 3.2 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Taxilin PF09728.9 CDI77256.1 - 4.9 6.2 23.2 0.36 10.0 12.3 2.0 1 1 1 2 2 2 0 Myosin-like coiled-coil protein GAS PF13851.6 CDI77256.1 - 5.6 6.3 24.6 22 4.3 24.0 2.1 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fmp27_WPPW PF10359.9 CDI77256.1 - 6.3 5.5 11.0 9.7 4.9 11.0 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Herpes_UL6 PF01763.16 CDI77256.1 - 7.8 4.9 9.1 17 3.7 9.1 1.5 1 1 0 1 1 1 0 Herpesvirus UL6 like PRP1_N PF06424.12 CDI77258.1 - 8.1e-51 172.3 9.3 4e-43 147.3 0.7 3.2 3 0 0 3 3 3 2 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CDI77258.1 - 8.5e-28 94.7 30.5 0.0011 19.6 0.5 14.6 6 3 9 15 15 15 8 Tetratricopeptide repeat TPR_19 PF14559.6 CDI77258.1 - 5.7e-18 65.2 15.1 0.001 19.5 0.3 9.0 6 3 3 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDI77258.1 - 1.7e-07 31.8 14.1 0.00029 21.4 0.0 8.2 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI77258.1 - 1.1e-06 28.2 12.6 5.3 7.4 0.2 9.9 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI77258.1 - 3.8e-06 26.7 1.7 13 6.3 0.0 7.9 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI77258.1 - 6.4e-05 22.5 0.0 1.8 8.3 0.0 4.7 5 0 0 5 5 5 2 TPR repeat Suf PF05843.14 CDI77258.1 - 7.8e-05 22.8 0.0 8.9 6.2 0.1 4.9 3 3 0 3 3 3 1 Suppressor of forked protein (Suf) TPR_17 PF13431.6 CDI77258.1 - 0.00012 22.2 7.1 0.42 11.1 0.0 8.5 12 3 2 14 14 9 1 Tetratricopeptide repeat ChAPs PF09295.10 CDI77258.1 - 0.00077 18.6 7.8 0.054 12.5 0.1 4.0 2 1 1 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 CDI77258.1 - 0.0013 18.9 7.2 0.45 10.8 0.4 5.1 4 2 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDI77258.1 - 0.0047 17.2 11.4 1.5 9.2 0.1 6.6 7 1 0 7 7 7 1 Tetratricopeptide repeat DUF3808 PF10300.9 CDI77258.1 - 0.0092 14.8 1.9 0.69 8.6 0.1 3.9 4 1 1 5 5 5 1 Protein of unknown function (DUF3808) TPR_9 PF13371.6 CDI77258.1 - 0.012 15.8 7.9 0.88 9.8 0.1 5.4 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDI77258.1 - 0.042 13.6 16.1 0.075 12.7 5.5 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain SCAN PF02023.17 CDI77258.1 - 0.33 10.8 4.1 3.9 7.4 0.1 3.9 2 1 1 3 3 3 0 SCAN domain TPR_1 PF00515.28 CDI77258.1 - 0.4 10.6 1.7 3.6 7.6 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat Tho2 PF11262.8 CDI77258.1 - 1.5 8.0 4.4 0.96 8.6 1.4 2.2 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 TPR_6 PF13174.6 CDI77258.1 - 4.2 8.2 18.9 33 5.4 0.0 7.7 9 0 0 9 9 8 0 Tetratricopeptide repeat Sec1 PF00995.23 CDI77261.1 - 5.4e-63 214.1 0.0 2e-62 212.3 0.0 1.9 1 1 0 1 1 1 1 Sec1 family TFIIA PF03153.13 CDI77261.1 - 0.028 14.4 22.4 0.55 10.2 3.4 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI77261.1 - 2.3 7.1 12.7 0.25 10.2 1.9 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Ephrin_rec_like PF07699.13 CDI77263.1 - 1.2e-21 76.2 97.0 1e-07 31.6 4.6 9.2 10 0 0 10 10 10 6 Putative ephrin-receptor like PAN_4 PF14295.6 CDI77263.1 - 0.0035 17.2 0.2 0.027 14.4 0.2 2.6 1 0 0 1 1 1 1 PAN domain Uso1_p115_C PF04871.13 CDI77263.1 - 0.019 15.4 3.1 0.041 14.3 3.1 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region HALZ PF02183.18 CDI77263.1 - 0.089 13.0 0.9 0.19 12.0 0.9 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper He_PIG PF05345.12 CDI77263.1 - 0.31 11.3 2.1 1 9.6 0.3 2.8 2 0 0 2 2 2 0 Putative Ig domain Amino_oxidase PF01593.24 CDI77264.1 - 2.6e-34 119.3 5.6 4.1e-25 89.0 0.0 3.3 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI77264.1 - 1.2e-12 47.8 0.2 3.6e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDI77264.1 - 4.3e-06 26.1 3.8 8.2e-06 25.1 3.8 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDI77264.1 - 5.1e-06 26.3 0.0 1.2e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDI77264.1 - 7.3e-06 25.4 0.2 1.4e-05 24.5 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDI77264.1 - 2.1e-05 24.1 0.6 2.1e-05 24.1 0.6 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CDI77264.1 - 0.00022 20.6 0.4 0.00045 19.6 0.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDI77264.1 - 0.0008 18.7 0.3 0.0016 17.7 0.3 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CDI77264.1 - 0.0012 19.3 0.2 0.0029 18.1 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDI77264.1 - 0.0051 15.6 0.8 0.0051 15.6 0.8 2.3 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CDI77264.1 - 0.0074 15.4 2.1 0.013 14.6 2.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Tam41_Mmp37 PF09139.11 CDI77264.1 - 1.6 8.1 3.5 3.2 7.1 3.5 1.4 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial OTU PF02338.19 CDI77265.1 - 0.00082 19.9 2.4 0.002 18.6 0.0 2.5 2 1 0 2 2 2 1 OTU-like cysteine protease TFIIA PF03153.13 CDI77265.1 - 0.002 18.2 8.0 0.0026 17.9 8.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI77265.1 - 1.6 8.3 8.5 2.5 7.7 8.5 1.3 1 0 0 1 1 1 0 Spt20 family PseudoU_synth_2 PF00849.22 CDI77266.1 - 6.1e-23 81.7 0.1 6.1e-23 81.7 0.1 3.2 3 0 0 3 3 3 1 RNA pseudouridylate synthase AMPK1_CBM PF16561.5 CDI77268.1 - 4.6e-18 65.2 0.0 1.1e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase TFIIA PF03153.13 CDI77268.1 - 0.014 15.4 10.3 0.018 15.1 10.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCDC24 PF15669.5 CDI77268.1 - 0.036 14.0 6.8 0.057 13.3 6.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Spt20 PF12090.8 CDI77268.1 - 0.11 12.1 10.6 0.16 11.6 10.6 1.2 1 0 0 1 1 1 0 Spt20 family Macoilin PF09726.9 CDI77268.1 - 0.11 11.0 11.2 0.15 10.6 11.2 1.1 1 0 0 1 1 1 0 Macoilin family TAF4 PF05236.14 CDI77268.1 - 0.14 11.9 9.9 0.2 11.4 9.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Presenilin PF01080.17 CDI77268.1 - 0.28 9.9 4.9 0.32 9.7 4.9 1.1 1 0 0 1 1 1 0 Presenilin DUF572 PF04502.13 CDI77268.1 - 0.46 10.1 6.2 0.56 9.8 6.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lin-8 PF03353.15 CDI77268.1 - 0.63 9.5 6.9 0.94 9.0 6.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI77268.1 - 0.65 8.8 10.2 0.83 8.4 10.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sporozoite_P67 PF05642.11 CDI77268.1 - 0.68 7.9 8.0 0.9 7.5 8.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MPM1 PF17234.2 CDI77268.1 - 0.91 9.8 9.1 1.4 9.1 9.1 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 HSD3 PF15244.6 CDI77268.1 - 1.4 8.4 13.4 1.9 7.9 13.4 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 Hid1 PF12722.7 CDI77268.1 - 1.4 7.0 6.3 1.6 6.8 6.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Smg8_Smg9 PF10220.9 CDI77268.1 - 6 5.1 8.5 7.6 4.7 8.5 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Miga PF10265.9 CDI77268.1 - 8.1 5.3 11.4 11 4.9 11.4 1.1 1 0 0 1 1 1 0 Mitoguardin Metal_resist PF13801.6 CDI77270.1 - 0.0083 16.3 11.3 0.0083 16.3 11.3 6.4 4 3 3 7 7 7 1 Heavy-metal resistance Enolase_N PF03952.16 CDI77270.1 - 0.023 14.9 0.1 0.023 14.9 0.1 2.9 3 1 0 3 3 3 0 Enolase, N-terminal domain DUF2274 PF10038.9 CDI77270.1 - 0.041 14.3 1.1 0.2 12.1 1.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) Peptidase_M3_N PF08439.10 CDI77270.1 - 0.12 12.7 0.8 0.38 11.0 0.8 1.8 1 0 0 1 1 1 0 Oligopeptidase F Apolipoprotein PF01442.18 CDI77270.1 - 0.34 10.8 50.6 3.7 7.4 6.0 3.4 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1266 PF06889.11 CDI77270.1 - 1.9 8.5 14.2 0.25 11.4 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1266) Bax1-I PF01027.20 CDI77271.1 - 0.00024 21.0 4.8 0.00031 20.6 4.8 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2981 PF11200.8 CDI77271.1 - 0.43 10.3 2.6 0.6 9.8 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF3487 PF11990.8 CDI77271.1 - 0.46 10.4 4.3 0.73 9.7 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Pkinase PF00069.25 CDI77273.1 - 2.4e-60 204.1 0.0 3.2e-60 203.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77273.1 - 4.2e-31 108.2 0.0 6.4e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI77273.1 - 8e-08 31.9 0.0 1.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDI77273.1 - 0.001 18.5 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI77273.1 - 0.0049 16.8 0.4 0.021 14.8 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDI77273.1 - 0.013 14.5 0.0 0.013 14.5 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 CDI77273.1 - 0.05 13.1 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL YukC PF10140.9 CDI77273.1 - 0.097 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC AdenylateSensor PF16579.5 CDI77273.1 - 0.12 12.8 0.2 6.9 7.2 0.0 3.3 1 1 2 3 3 3 0 Adenylate sensor of SNF1-like protein kinase Choline_kinase PF01633.20 CDI77273.1 - 0.22 11.1 0.1 0.41 10.2 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Spt20 PF12090.8 CDI77273.1 - 0.27 10.8 5.3 0.42 10.2 5.3 1.3 1 0 0 1 1 1 0 Spt20 family Porphobil_deam PF01379.20 CDI77274.1 - 4.3e-45 153.7 9.0 8.4e-42 143.0 9.0 3.5 1 1 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CDI77274.1 - 2e-11 44.1 0.1 1.3e-10 41.5 0.1 2.4 1 1 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Spt20 PF12090.8 CDI77274.1 - 0.00067 19.3 9.9 0.00067 19.3 9.9 3.2 3 1 0 3 3 3 1 Spt20 family DUF2722 PF10846.8 CDI77274.1 - 0.0089 15.0 9.9 0.0089 15.0 9.9 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) cwf18 PF08315.12 CDI77274.1 - 0.047 14.4 1.2 0.047 14.4 1.2 3.0 4 0 0 4 4 4 0 cwf18 pre-mRNA splicing factor EIF4E-T PF10477.9 CDI77274.1 - 0.72 8.6 10.5 0.08 11.8 3.6 2.2 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4834 PF16118.5 CDI77274.1 - 2.6 9.1 5.9 6.2 7.9 3.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Glyco_transf_5 PF08323.11 CDI77275.1 - 8.5e-31 107.5 0.0 2.9e-30 105.8 0.0 1.9 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CDI77275.1 - 1.3e-06 28.0 0.1 5.9e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 ELO PF01151.18 CDI77277.1 - 2.6e-11 43.5 0.6 3.4e-11 43.1 0.6 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family YMF19 PF02326.15 CDI77277.1 - 0.035 14.9 0.6 0.23 12.3 0.1 2.3 2 0 0 2 2 2 0 Plant ATP synthase F0 DUF4834 PF16118.5 CDI77277.1 - 0.099 13.6 0.1 0.17 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.22 CDI77277.1 - 0.14 11.4 2.1 0.1 11.8 0.4 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter PI3_PI4_kinase PF00454.27 CDI77278.1 - 7.3e-10 39.1 0.0 8.8e-09 35.5 0.0 2.3 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CDI77278.1 - 0.0049 16.6 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 FATC domain E1-E2_ATPase PF00122.20 CDI77279.1 - 7.8e-15 54.9 0.0 1.9e-14 53.6 0.0 4.2 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 CDI77279.1 - 5.1e-11 43.2 0.0 1.1e-08 35.6 0.2 6.7 6 1 0 6 6 6 2 haloacid dehalogenase-like hydrolase AF-4 PF05110.13 CDI77280.1 - 0.029 12.5 9.4 0.027 12.6 9.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 CDI77280.1 - 0.072 11.6 2.2 0.089 11.3 2.2 1.2 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 CDI77280.1 - 0.25 11.9 2.5 0.39 11.3 2.5 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein SUZ PF12752.7 CDI77280.1 - 2.9 8.7 9.4 4.9 8.0 3.2 3.3 3 1 0 3 3 3 0 SUZ domain Myosin_head PF00063.21 CDI77282.1 - 1.1e-150 503.1 13.3 1.8e-86 290.9 6.5 4.0 4 0 0 4 4 4 4 Myosin head (motor domain) Peptidase_M9_N PF08453.10 CDI77282.1 - 0.011 15.4 4.8 0.5 10.1 0.0 2.5 2 0 0 2 2 2 0 Peptidase family M9 N-terminal SR-25 PF10500.9 CDI77282.1 - 0.034 13.7 37.6 0.27 10.8 14.4 3.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein DUF1645 PF07816.11 CDI77282.1 - 1.1 9.8 18.5 1.6 9.2 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1645) Activator_LAG-3 PF11498.8 CDI77282.1 - 2.5 6.9 36.2 0.83 8.6 20.5 2.7 2 0 0 2 2 2 0 Transcriptional activator LAG-3 SUZ PF12752.7 CDI77282.1 - 3 8.7 12.0 1 10.2 0.5 3.7 3 0 0 3 3 3 0 SUZ domain SelK_SelG PF10961.8 CDI77282.1 - 7.9 7.2 10.7 0.4 11.3 0.1 3.4 4 0 0 4 4 4 0 Selenoprotein SelK_SelG AF-4 PF05110.13 CDI77282.1 - 8.4 4.3 30.6 0.045 11.8 14.1 2.4 2 0 0 2 2 2 0 AF-4 proto-oncoprotein RskA PF10099.9 CDI77284.1 - 0.15 12.3 16.4 0.25 11.6 7.8 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA V_ATPase_I PF01496.19 CDI77285.1 - 1.4 6.7 5.9 1.8 6.4 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI77285.1 - 8.6 5.3 6.9 13 4.7 6.9 1.2 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI77285.1 - 8.9 6.3 7.8 11 6.0 4.3 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SUIM_assoc PF16619.5 CDI77285.1 - 9.7 6.3 29.6 2.1e+03 -1.1 0.5 4.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Peptidase_C97 PF05903.14 CDI77286.1 - 3.4e-06 27.0 0.0 5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF2353 PF09789.9 CDI77286.1 - 0.049 13.0 15.7 0.068 12.5 15.7 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) LURAP PF14854.6 CDI77286.1 - 0.11 12.4 5.1 0.17 11.8 5.1 1.3 1 0 0 1 1 1 0 Leucine rich adaptor protein GREB1 PF15782.5 CDI77286.1 - 1.2 6.1 10.9 1.5 5.8 10.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Plasmodium_Vir PF05795.11 CDI77286.1 - 1.4 8.3 5.8 1.8 7.9 5.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TFIIA PF03153.13 CDI77286.1 - 1.4 8.9 22.2 1.8 8.5 22.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRP-alpha_N PF04086.13 CDI77286.1 - 3.4 7.5 14.4 4.8 7.0 14.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Atg14 PF10186.9 CDI77286.1 - 4.3 6.3 20.5 5.8 5.9 20.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 K_oxygenase PF13434.6 CDI77286.1 - 5.3 6.1 10.6 7.4 5.6 10.6 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FUSC PF04632.12 CDI77286.1 - 6.7 5.1 10.3 10 4.5 10.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Peptidase_C97 PF05903.14 CDI77287.1 - 5.6e-15 55.5 0.0 7.7e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF4179 PF13786.6 CDI77288.1 - 0.14 12.6 2.1 15 6.2 1.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) ETRAMP PF09716.10 CDI77288.1 - 0.48 10.5 0.0 0.48 10.5 0.0 3.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) NiFeSe_Hases PF00374.19 CDI77289.1 - 0.023 13.6 0.7 0.039 12.8 0.7 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase DUF4647 PF15504.6 CDI77289.1 - 0.06 12.4 6.6 0.096 11.8 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Band_3_cyto PF07565.13 CDI77289.1 - 0.36 10.6 2.7 0.71 9.6 2.7 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TERB2 PF15101.6 CDI77289.1 - 0.79 9.7 9.2 1.9 8.5 9.2 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Exostosin PF03016.15 CDI77289.1 - 1.1 8.4 7.1 0.14 11.3 1.0 2.2 2 0 0 2 2 2 0 Exostosin family Pannexin_like PF12534.8 CDI77289.1 - 1.6 7.8 3.9 3 6.8 3.9 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DDHD PF02862.17 CDI77289.1 - 2.5 8.2 6.8 0.21 11.7 0.9 2.1 3 0 0 3 3 3 0 DDHD domain Presenilin PF01080.17 CDI77289.1 - 7.9 5.1 9.0 15 4.2 9.0 1.4 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CDI77290.1 - 0.0007 18.3 20.3 0.0007 18.3 20.3 3.8 2 1 0 2 2 2 1 Macoilin family Lin-8 PF03353.15 CDI77290.1 - 4.4 6.8 43.6 0.18 11.4 24.1 3.5 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist Neurensin PF14927.6 CDI77291.1 - 0.0087 15.8 0.0 0.0092 15.7 0.0 1.2 1 0 0 1 1 1 1 Neurensin DUF624 PF04854.14 CDI77291.1 - 0.043 13.9 0.1 0.053 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF624 DUF2371 PF10177.9 CDI77291.1 - 0.12 12.5 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) LD_cluster3 PF18180.1 CDI77292.1 - 0.15 11.6 0.0 18 4.9 0.0 2.1 2 0 0 2 2 2 0 SLOG cluster3 family SR-25 PF10500.9 CDI77294.1 - 0.36 10.4 31.7 3 7.4 16.3 3.2 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein BES1_N PF05687.13 CDI77294.1 - 2.8 8.3 13.8 1.7 9.0 0.6 3.0 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal DUF5560 PF17715.1 CDI77295.1 - 0.19 11.2 4.0 0.18 11.3 4.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5560) Spt20 PF12090.8 CDI77296.1 - 0.0038 16.9 24.4 0.0038 16.9 24.4 1.8 2 0 0 2 2 2 1 Spt20 family Apt1 PF10351.9 CDI77296.1 - 0.056 12.3 9.4 0.035 13.0 7.2 1.7 2 0 0 2 2 2 0 Golgi-body localisation protein domain RAP1 PF07218.11 CDI77296.1 - 1.1 7.4 17.6 1.2 7.4 6.4 2.0 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) DUF1635 PF07795.11 CDI77296.1 - 1.5 8.7 14.7 2.8 7.7 14.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Lin-8 PF03353.15 CDI77296.1 - 7.6 6.0 18.3 13 5.2 18.3 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Dicty_REP PF05086.12 CDI77296.1 - 8.4 4.2 12.3 12 3.7 12.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PCI PF01399.27 CDI77298.1 - 2.3e-16 60.2 3.8 8.5e-16 58.4 0.1 2.4 2 0 0 2 2 2 1 PCI domain RPN6_N PF18055.1 CDI77298.1 - 8.2e-15 55.2 0.0 6.2e-14 52.4 0.0 2.5 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain DUF410 PF04190.13 CDI77298.1 - 0.0038 17.1 2.9 0.016 15.1 0.0 2.7 3 1 0 3 3 3 1 Protein of unknown function (DUF410) RPN6_C_helix PF18503.1 CDI77298.1 - 0.014 15.1 0.3 0.029 14.1 0.3 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain CASP_C PF08172.12 CDI77298.1 - 3 7.1 8.8 2.2 7.6 0.6 2.3 2 0 0 2 2 2 0 CASP C terminal Di19_C PF14571.6 CDI77299.1 - 0.0069 16.9 1.9 0.01 16.4 1.9 1.1 1 0 0 1 1 1 1 Stress-induced protein Di19, C-terminal TERB2 PF15101.6 CDI77299.1 - 0.0097 16.0 4.1 0.0097 16.0 4.1 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 DUF2722 PF10846.8 CDI77299.1 - 0.014 14.3 15.1 0.015 14.3 15.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2407 PF10302.9 CDI77299.1 - 0.015 15.8 4.1 0.02 15.4 4.1 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain SpoIIP PF07454.11 CDI77299.1 - 0.025 14.0 2.1 0.022 14.2 2.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4628 PF15429.6 CDI77299.1 - 0.025 14.3 2.8 0.025 14.3 2.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) NARP1 PF12569.8 CDI77299.1 - 0.041 12.8 4.5 0.044 12.7 4.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Med15 PF09606.10 CDI77299.1 - 0.044 12.5 15.1 0.043 12.5 15.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2227 PF09988.9 CDI77299.1 - 0.05 13.5 0.4 0.056 13.3 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) TFIIA PF03153.13 CDI77299.1 - 0.061 13.3 16.2 0.061 13.3 16.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI77299.1 - 0.083 11.4 2.1 0.087 11.3 2.1 1.0 1 0 0 1 1 1 0 FHIPEP family Presenilin PF01080.17 CDI77299.1 - 0.1 11.4 3.2 0.11 11.2 3.2 1.0 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 CDI77299.1 - 0.16 11.7 3.7 0.19 11.5 3.7 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 V_ATPase_I PF01496.19 CDI77299.1 - 0.16 9.9 3.3 0.17 9.7 3.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Suf PF05843.14 CDI77299.1 - 0.18 11.8 7.6 0.19 11.7 7.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EIIBC-GUT_N PF03612.14 CDI77299.1 - 0.3 10.8 3.7 0.35 10.6 3.7 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DcuA_DcuB PF03605.14 CDI77299.1 - 0.3 9.9 0.5 0.32 9.8 0.5 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF775 PF05603.12 CDI77299.1 - 0.31 10.5 5.7 0.32 10.5 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF4834 PF16118.5 CDI77299.1 - 0.33 11.9 7.7 0.41 11.6 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) VIT1 PF01988.19 CDI77299.1 - 0.8 9.5 3.4 0.92 9.3 3.4 1.1 1 0 0 1 1 1 0 VIT family USP8_interact PF08941.10 CDI77299.1 - 0.9 9.3 10.6 1.1 9.0 10.6 1.1 1 0 0 1 1 1 0 USP8 interacting CobT PF06213.12 CDI77299.1 - 1.1 8.6 11.6 1.4 8.3 11.6 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TMEM51 PF15345.6 CDI77299.1 - 1.1 9.0 10.5 1.3 8.8 10.5 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Rpp20 PF12328.8 CDI77299.1 - 1.8 8.5 7.6 2.2 8.3 7.6 1.1 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P 60KD_IMP PF02096.20 CDI77299.1 - 1.8 8.4 9.1 2.1 8.2 9.1 1.1 1 0 0 1 1 1 0 60Kd inner membrane protein MscS_TM PF12794.7 CDI77299.1 - 1.8 7.3 7.2 2.1 7.1 7.2 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 EMC3_TMCO1 PF01956.16 CDI77299.1 - 2.1 8.0 6.4 2.3 7.9 6.4 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF4175 PF13779.6 CDI77299.1 - 2.3 6.0 19.0 2.4 5.9 19.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Roughex PF06020.11 CDI77299.1 - 2.4 7.2 10.9 2.4 7.2 10.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 CDI77299.1 - 5.3 6.6 27.6 6.6 6.3 27.6 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI77299.1 - 6.5 5.1 12.4 7 5.0 12.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 NOG1_N PF17835.1 CDI77300.1 - 1.7e-36 125.6 0.1 2.1e-36 125.3 0.1 1.0 1 0 0 1 1 1 1 NOG1 N-terminal helical domain MMR_HSR1 PF01926.23 CDI77300.1 - 3.7e-05 23.8 0.0 8.9e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDI77300.1 - 0.099 12.7 0.1 0.38 10.8 0.0 1.9 2 0 0 2 2 2 0 Dynamin family Vps16_N PF04841.13 CDI77302.1 - 7.1e-06 25.0 0.1 7.1e-06 25.0 0.1 1.0 1 0 0 1 1 1 1 Vps16, N-terminal region PNP_UDP_1 PF01048.20 CDI77303.1 - 3.3e-20 72.4 0.0 3.8e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Holin_2-3 PF13272.6 CDI77304.1 - 0.63 10.4 5.4 14 6.0 0.4 2.9 2 0 0 2 2 2 0 Putative 2/3 transmembrane domain holin CCSAP PF15748.5 CDI77305.1 - 0.23 11.6 36.6 0.3 11.2 36.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Endostatin PF06482.11 CDI77305.1 - 0.78 9.2 27.6 0.93 8.9 27.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RR_TM4-6 PF06459.12 CDI77305.1 - 0.88 9.3 23.7 1.1 9.0 23.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI77305.1 - 1 9.5 24.5 1.3 9.1 24.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) AF-4 PF05110.13 CDI77305.1 - 1.4 6.9 37.3 1.5 6.8 37.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein eIF-3_zeta PF05091.12 CDI77305.1 - 1.4 7.8 28.3 1.6 7.7 28.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4746 PF15928.5 CDI77305.1 - 1.4 8.2 15.2 1.7 8.0 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Asp-B-Hydro_N PF05279.11 CDI77305.1 - 1.6 8.7 15.2 1.7 8.6 15.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SR-25 PF10500.9 CDI77305.1 - 1.7 8.2 35.6 5.4 6.6 35.7 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein CLN3 PF02487.17 CDI77305.1 - 2.3 7.2 14.7 2.6 7.0 14.7 1.3 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 CDI77305.1 - 2.6 7.5 17.9 3.1 7.2 17.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 CAC1F_C PF16885.5 CDI77305.1 - 2.8 7.5 23.2 3.3 7.3 23.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF3381 PF11861.8 CDI77305.1 - 3.5 7.4 24.1 4.6 7.0 24.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Presenilin PF01080.17 CDI77305.1 - 3.6 6.3 32.2 4 6.1 32.2 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 CDI77305.1 - 3.9 5.8 23.6 4.8 5.5 23.6 1.2 1 0 0 1 1 1 0 Peptidase family S64 DDRGK PF09756.9 CDI77305.1 - 3.9 7.0 29.4 5.6 6.5 29.4 1.2 1 0 0 1 1 1 0 DDRGK domain DUF853 PF05872.12 CDI77305.1 - 4.4 5.8 14.5 5 5.6 14.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) TCP PF03634.13 CDI77305.1 - 4.5 7.8 33.5 6 7.4 33.5 1.2 1 0 0 1 1 1 0 TCP family transcription factor PA26 PF04636.13 CDI77305.1 - 4.9 6.0 19.6 6.8 5.5 19.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Ten_N PF06484.12 CDI77305.1 - 5.2 6.8 25.5 5.6 6.7 25.5 1.0 1 0 0 1 1 1 0 Teneurin Intracellular Region DUF4661 PF15576.6 CDI77305.1 - 5.7 6.8 11.5 6.8 6.5 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) BPL_N PF09825.9 CDI77305.1 - 6.5 5.7 16.4 7.8 5.5 16.4 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal SpoIIP PF07454.11 CDI77305.1 - 8.6 5.7 27.7 12 5.3 27.7 1.3 1 1 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI77307.1 - 0.0085 16.1 24.6 0.012 15.6 24.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI77307.1 - 1.5 8.3 13.3 2.2 7.8 13.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 CDI77307.1 - 2.8 6.1 16.2 3.3 5.9 16.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MCM PF00493.23 CDI77314.1 - 1.7e-82 275.9 0.0 3.4e-82 274.9 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDI77314.1 - 9.4e-21 74.0 1.4 3.7e-20 72.1 1.4 2.0 1 1 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 CDI77314.1 - 1.2e-06 28.0 0.1 0.00067 19.1 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDI77314.1 - 0.00052 19.9 0.4 0.0053 16.6 0.0 3.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) SF1-HH PF16275.5 CDI77314.1 - 0.005 17.2 3.5 0.012 16.0 3.5 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain AAA_5 PF07728.14 CDI77314.1 - 0.0063 16.5 0.0 0.016 15.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDI77314.1 - 0.048 13.4 0.0 1.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain E7 PF00527.18 CDI77314.1 - 0.44 10.8 2.8 1.4 9.2 0.4 2.7 2 0 0 2 2 2 0 E7 protein, Early protein RskA PF10099.9 CDI77314.1 - 4 7.7 44.8 0.43 10.9 9.4 5.2 5 0 0 5 5 5 0 Anti-sigma-K factor rskA Cwf_Cwc_15 PF04889.12 CDI77315.1 - 0.00012 21.9 10.1 0.00015 21.6 10.1 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DcuA_DcuB PF03605.14 CDI77315.1 - 0.014 14.4 0.2 0.014 14.4 0.2 1.6 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Presenilin PF01080.17 CDI77315.1 - 0.25 10.1 16.8 0.33 9.7 16.8 1.1 1 0 0 1 1 1 0 Presenilin Pinin_SDK_memA PF04696.13 CDI77315.1 - 2.2 8.3 24.3 0.53 10.3 10.8 2.1 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region SR-25 PF10500.9 CDI77315.1 - 4.2 6.9 21.6 25 4.4 21.6 1.9 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peroxin-13_N PF04088.13 CDI77315.1 - 6.9 6.9 11.5 1.7 8.9 2.1 2.1 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Kei1 PF08552.11 CDI77315.1 - 8.7 6.2 13.7 0.78 9.6 2.2 2.1 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Coilin_N PF15862.5 CDI77315.1 - 8.9 6.1 22.5 0.71 9.7 7.1 2.1 2 0 0 2 2 2 0 Coilin N-terminus ketoacyl-synt PF00109.26 CDI77317.1 - 1.8e-42 145.7 0.4 1.8e-42 145.7 0.4 5.9 5 0 0 5 5 5 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 CDI77317.1 - 6.3e-40 137.1 0.0 3.2e-24 85.3 0.0 3.2 2 1 0 2 2 2 2 AMP-binding enzyme Ketoacyl-synt_C PF02801.22 CDI77317.1 - 1.4e-18 67.0 2.0 4.4e-15 55.7 0.2 5.1 4 0 0 4 4 4 2 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDI77317.1 - 1.1e-06 28.9 0.1 1.3e-05 25.5 0.2 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site DUF840 PF05801.11 CDI77317.1 - 0.095 12.8 0.9 0.57 10.3 0.9 2.4 1 0 0 1 1 1 0 Lagovirus protein of unknown function (DUF840) DUF4746 PF15928.5 CDI77317.1 - 8.8 5.7 7.4 68 2.7 7.4 2.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DEAD PF00270.29 CDI77319.1 - 5.8e-13 49.0 18.6 2.1e-07 30.9 1.0 3.9 3 1 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI77319.1 - 1.6e-10 41.3 3.5 6.4e-10 39.4 0.0 3.9 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Macoilin PF09726.9 CDI77319.1 - 0.00059 18.5 4.5 0.00059 18.5 4.5 4.7 3 1 0 4 4 4 1 Macoilin family DUF4667 PF15700.5 CDI77319.1 - 0.00095 19.3 6.9 0.00095 19.3 6.9 5.6 3 1 0 4 4 4 1 Domain of unknown function (DUF4667) SPX PF03105.19 CDI77319.1 - 0.0087 16.0 5.4 0.0087 16.0 5.4 5.0 2 1 2 4 4 4 1 SPX domain INSIG PF07281.12 CDI77319.1 - 6.6 6.3 10.3 1.4 8.5 3.1 3.5 3 1 0 3 3 3 0 Insulin-induced protein (INSIG) Baculo_PP31 PF05311.11 CDI77320.1 - 0.028 13.9 6.7 0.054 13.0 6.7 1.6 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SID-1_RNA_chan PF13965.6 CDI77320.1 - 0.23 9.8 3.4 0.29 9.5 3.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI77320.1 - 0.3 8.9 18.0 0.5 8.2 18.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 CDI77320.1 - 0.5 10.1 12.5 0.059 13.2 7.9 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain eIF-3_zeta PF05091.12 CDI77320.1 - 0.59 9.0 17.8 0.9 8.4 17.8 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC45 PF02724.14 CDI77320.1 - 0.61 8.3 19.8 0.0085 14.4 12.3 1.7 2 0 0 2 2 2 0 CDC45-like protein CLN3 PF02487.17 CDI77320.1 - 0.8 8.7 11.8 2.2 7.2 11.8 1.7 1 0 0 1 1 1 0 CLN3 protein DUF2151 PF10221.9 CDI77320.1 - 0.82 8.2 10.0 1.4 7.4 10.0 1.4 1 0 0 1 1 1 0 Cell cycle and development regulator ALMT PF11744.8 CDI77320.1 - 2.3 7.0 17.2 5.6 5.7 17.2 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 CDI77320.1 - 3.2 6.9 11.0 7.5 5.7 11.0 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 CDI77320.1 - 6.6 5.6 9.1 11 4.8 9.1 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator SpoIIP PF07454.11 CDI77320.1 - 6.7 6.1 24.1 0.11 12.0 16.1 2.1 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Nop14 PF04147.12 CDI77320.1 - 8.1 4.5 28.4 0.35 9.0 17.4 2.3 2 0 0 2 2 2 0 Nop14-like family Adap_comp_sub PF00928.21 CDI77323.1 - 1.3e-25 90.3 0.0 1.5e-25 90.1 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family SNF2_N PF00176.23 CDI77325.1 - 2.3e-64 217.3 4.5 2.3e-64 217.3 4.5 2.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI77325.1 - 1.1e-10 41.8 0.1 5.3e-10 39.6 0.1 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_25 PF13481.6 CDI77325.1 - 0.064 12.8 0.4 0.2 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain zf-HC2 PF13490.6 CDI77327.1 - 0.36 11.1 2.2 0.79 10.0 2.2 1.6 1 0 0 1 1 1 0 Putative zinc-finger Ubiq_cyt_C_chap PF03981.12 CDI77328.1 - 2.4 8.3 9.9 1.8 8.6 0.2 2.5 2 1 0 2 2 2 0 Ubiquinol-cytochrome C chaperone mRNA_triPase PF02940.15 CDI77329.1 - 2.4e-13 50.3 0.0 4.7e-07 29.8 0.0 3.8 2 2 0 2 2 2 2 mRNA capping enzyme, beta chain DUF5308 PF17233.2 CDI77330.1 - 0.017 15.3 7.7 0.025 14.8 7.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF2722 PF10846.8 CDI77330.1 - 0.034 13.1 16.6 0.032 13.2 16.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4719 PF15843.5 CDI77330.1 - 0.33 11.1 4.6 0.38 10.8 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) Spt20 PF12090.8 CDI77330.1 - 0.34 10.5 29.2 0.014 15.0 24.1 1.3 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI77330.1 - 0.43 10.5 22.8 0.41 10.6 22.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF702 PF05142.12 CDI77330.1 - 0.45 11.0 7.6 0.51 10.8 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) EPL1 PF10513.9 CDI77330.1 - 0.57 10.6 7.1 0.58 10.5 7.1 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Tristanin_u2 PF16638.5 CDI77330.1 - 1.7 9.5 12.4 2.4 9.0 12.4 1.2 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Fig1 PF12351.8 CDI77330.1 - 2.5 8.0 5.8 3 7.7 5.8 1.1 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 DUF4175 PF13779.6 CDI77330.1 - 3.1 5.6 18.2 2.9 5.7 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Roughex PF06020.11 CDI77330.1 - 3.6 6.6 12.4 4.7 6.2 12.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI77330.1 - 5.7 6.7 9.6 7.4 6.3 9.6 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_M22 PF00814.25 CDI77331.1 - 2.2e-20 73.5 28.1 2.7e-07 30.6 0.1 6.8 7 1 0 7 7 7 6 Glycoprotease family Tim54 PF11711.8 CDI77331.1 - 0.36 9.6 36.2 0.037 12.8 10.8 4.2 4 0 0 4 4 4 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 CDI77331.1 - 0.4 9.4 53.8 0.043 12.6 15.6 4.4 4 0 0 4 4 4 0 Presenilin SpoIIIAH PF12685.7 CDI77331.1 - 0.88 9.4 40.8 0.022 14.6 3.4 4.6 4 0 0 4 4 4 0 SpoIIIAH-like protein CLN3 PF02487.17 CDI77331.1 - 1.3 8.0 32.9 0.33 9.9 2.3 4.3 4 0 0 4 4 4 0 CLN3 protein Motile_Sperm PF00635.26 CDI77332.1 - 2.5e-20 72.4 0.0 3.9e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain SR-25 PF10500.9 CDI77332.1 - 0.0064 16.1 5.0 0.0095 15.6 5.0 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Med26_C PF15693.5 CDI77332.1 - 0.068 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal DAO PF01266.24 CDI77333.1 - 8.8e-08 32.1 1.1 1.3e-07 31.5 0.0 1.7 2 1 0 2 2 2 1 FAD dependent oxidoreductase UCH PF00443.29 CDI77336.1 - 2.6e-19 69.7 14.6 1.2e-11 44.6 0.0 4.3 4 0 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase Activator_LAG-3 PF11498.8 CDI77338.1 - 0.65 8.9 19.4 0.022 13.8 8.4 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF4834 PF16118.5 CDI77339.1 - 0.02 15.9 1.5 0.02 15.9 1.5 4.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Arm PF00514.23 CDI77339.1 - 0.023 14.8 0.1 0.35 11.0 0.0 2.7 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat DUF3306 PF11748.8 CDI77339.1 - 0.056 14.3 1.0 0.056 14.3 1.0 4.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) RICTOR_N PF14664.6 CDI77339.1 - 0.2 10.6 13.3 0.34 9.8 0.7 2.9 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term SMYLE_N PF18615.1 CDI77339.1 - 0.75 9.3 29.9 0.019 14.6 1.7 2.1 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Fumerase_C PF05683.12 CDI77340.1 - 9.9e-77 256.9 0.0 1.1e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Fumarase C-terminus Zip PF02535.22 CDI77342.1 - 1.4 8.1 31.0 1.7 7.8 31.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Aa_trans PF01490.18 CDI77342.1 - 2.7 6.6 4.2 2.9 6.5 4.1 1.2 1 1 0 1 1 1 0 Transmembrane amino acid transporter protein ALMT PF11744.8 CDI77342.1 - 9.9 4.9 32.2 10 4.8 32.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF702 PF05142.12 CDI77343.1 - 0.0078 16.7 1.9 0.012 16.1 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF702) CNDH2_C PF16858.5 CDI77343.1 - 0.034 14.0 7.4 0.039 13.8 7.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term NPR3 PF03666.13 CDI77343.1 - 0.036 12.9 4.1 0.035 12.9 4.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BNIP3 PF06553.12 CDI77343.1 - 0.044 13.4 9.0 0.05 13.3 9.0 1.1 1 0 0 1 1 1 0 BNIP3 DUF2722 PF10846.8 CDI77343.1 - 0.053 12.5 9.7 0.07 12.1 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI77343.1 - 0.055 12.2 4.5 0.056 12.2 4.5 1.2 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI77343.1 - 0.11 12.5 3.4 0.12 12.3 3.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A BUD22 PF09073.10 CDI77343.1 - 0.12 11.7 13.0 0.14 11.5 13.0 1.1 1 0 0 1 1 1 0 BUD22 PPL5 PF18168.1 CDI77343.1 - 0.12 11.7 5.4 0.13 11.5 5.4 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Herpes_env PF01673.18 CDI77343.1 - 0.14 11.0 1.2 0.15 11.0 1.2 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein DDHD PF02862.17 CDI77343.1 - 0.15 12.2 3.0 0.17 12.0 3.0 1.2 1 0 0 1 1 1 0 DDHD domain Dsh_C PF12316.8 CDI77343.1 - 0.17 12.3 6.5 0.21 12.0 6.5 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF913 PF06025.12 CDI77343.1 - 0.21 10.5 3.3 0.23 10.4 3.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 CDI77343.1 - 0.28 10.6 7.0 0.33 10.3 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPP4R2 PF09184.11 CDI77343.1 - 0.34 10.4 8.7 0.4 10.2 8.7 1.2 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 CDI77343.1 - 0.99 8.7 7.4 1.5 8.1 7.4 1.3 1 0 0 1 1 1 0 NOA36 protein TT_ORF2 PF02957.15 CDI77343.1 - 1 10.3 7.1 0.16 12.9 3.6 1.5 2 0 0 2 2 1 0 TT viral ORF2 Afi1 PF07792.12 CDI77343.1 - 1 9.8 9.1 0.69 10.4 7.6 1.5 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SLC12 PF03522.15 CDI77343.1 - 1.1 8.2 6.1 1.2 8.1 6.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Nucleo_P87 PF07267.11 CDI77343.1 - 2.5 6.8 9.6 3.7 6.3 9.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Fmp27 PF10344.9 CDI77343.1 - 2.9 5.9 6.2 3.6 5.6 6.2 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 DUF4366 PF14283.6 CDI77343.1 - 3.2 7.8 9.1 9.2 6.3 9.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DNA_pol_phi PF04931.13 CDI77343.1 - 3.8 5.5 15.8 4.7 5.2 15.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4834 PF16118.5 CDI77343.1 - 4.6 8.3 6.1 9.9 7.2 6.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Hid1 PF12722.7 CDI77343.1 - 5.8 4.9 7.5 5.9 4.9 7.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V_ATPase_I PF01496.19 CDI77343.1 - 7.7 4.3 7.1 9.3 4.0 7.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SUIM_assoc PF16619.5 CDI77345.1 - 0.0031 17.6 14.4 0.055 13.5 0.0 2.9 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI77345.1 - 0.1 12.2 12.1 0.34 10.5 5.3 2.1 2 0 0 2 2 2 0 Spt20 family QWRF PF04484.12 CDI77345.1 - 0.16 11.7 11.2 0.052 13.3 6.3 2.0 2 0 0 2 2 2 0 QWRF family Hamartin PF04388.12 CDI77345.1 - 0.16 10.6 4.6 0.18 10.4 4.6 1.0 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 CDI77345.1 - 0.58 9.7 9.5 0.15 11.6 4.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4820 PF16091.5 CDI77345.1 - 1.7 8.0 5.3 1.6 8.0 2.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF2722 PF10846.8 CDI77345.1 - 1.8 7.4 14.7 1.9 7.3 7.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) ECH_1 PF00378.20 CDI77347.1 - 3.7e-15 55.9 0.0 3.7e-15 55.9 0.0 2.1 1 1 1 2 2 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDI77347.1 - 0.00045 19.8 13.5 0.0054 16.3 13.4 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF4820 PF16091.5 CDI77347.1 - 0.0047 16.3 8.5 0.0061 16.0 8.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) SID-1_RNA_chan PF13965.6 CDI77347.1 - 0.0094 14.4 0.3 0.0094 14.4 0.3 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Velvet PF11754.8 CDI77347.1 - 0.028 14.4 13.3 0.033 14.1 13.3 1.1 1 0 0 1 1 1 0 Velvet factor Ureide_permease PF07168.11 CDI77347.1 - 0.043 12.6 3.7 0.055 12.2 3.7 1.1 1 0 0 1 1 1 0 Ureide permease TFIIA PF03153.13 CDI77347.1 - 0.094 12.7 37.3 0.11 12.5 37.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Coilin_N PF15862.5 CDI77347.1 - 0.096 12.5 12.7 0.15 11.8 12.7 1.4 1 0 0 1 1 1 0 Coilin N-terminus RNA_pol_Rbc25 PF08292.12 CDI77347.1 - 0.1 12.8 8.1 0.17 12.1 8.1 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 PAT1 PF09770.9 CDI77347.1 - 0.12 10.6 24.6 0.13 10.5 24.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.12 CDI77347.1 - 0.17 10.8 18.9 0.19 10.7 18.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ctr PF04145.15 CDI77347.1 - 0.18 12.4 5.9 0.28 11.8 5.9 1.3 1 0 0 1 1 1 0 Ctr copper transporter family DDHD PF02862.17 CDI77347.1 - 0.24 11.5 13.3 0.32 11.1 13.3 1.2 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 CDI77347.1 - 0.26 10.2 8.0 0.31 10.0 8.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Suf PF05843.14 CDI77347.1 - 0.3 11.0 16.6 0.39 10.7 16.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CLN3 PF02487.17 CDI77347.1 - 0.37 9.8 11.7 0.45 9.5 11.7 1.1 1 0 0 1 1 1 0 CLN3 protein RPOL_N PF14700.6 CDI77347.1 - 0.41 10.0 21.0 0.57 9.5 21.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DUF2828 PF11443.8 CDI77347.1 - 0.6 8.1 15.7 0.75 7.8 15.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CobT PF06213.12 CDI77347.1 - 0.72 9.2 22.6 0.97 8.8 22.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pex14_N PF04695.13 CDI77347.1 - 0.77 10.4 25.3 1.1 9.9 25.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EOS1 PF12326.8 CDI77347.1 - 0.86 9.5 8.8 1.2 9.0 8.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein CPSF100_C PF13299.6 CDI77347.1 - 1.1 9.4 12.9 1.5 8.9 12.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI77347.1 - 1.2 9.2 11.1 1.3 9.0 11.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI77347.1 - 1.2 7.9 13.0 1.3 7.7 13.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI77347.1 - 1.4 7.8 15.6 1.7 7.6 15.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TERB2 PF15101.6 CDI77347.1 - 1.5 8.8 26.1 2.2 8.3 26.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NEMP PF10225.9 CDI77347.1 - 1.5 8.4 8.3 2.1 8.0 8.3 1.2 1 0 0 1 1 1 0 NEMP family Gti1_Pac2 PF09729.9 CDI77347.1 - 1.7 8.7 13.1 2.2 8.4 13.1 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Folate_carrier PF01770.18 CDI77347.1 - 1.8 7.2 8.0 2.3 6.9 8.0 1.2 1 0 0 1 1 1 0 Reduced folate carrier EIIBC-GUT_N PF03612.14 CDI77347.1 - 1.8 8.2 14.7 2.7 7.7 14.7 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RR_TM4-6 PF06459.12 CDI77347.1 - 2 8.2 18.8 2.4 7.9 18.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AIF_C PF14721.6 CDI77347.1 - 2 8.8 12.8 3 8.2 12.8 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Serinc PF03348.15 CDI77347.1 - 2 7.2 8.3 2.8 6.8 8.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 CDI77347.1 - 2.4 6.8 21.1 2.8 6.6 21.1 1.1 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 CDI77347.1 - 2.5 7.8 15.3 3.5 7.3 15.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MCU PF04678.13 CDI77347.1 - 2.5 8.2 11.7 3.5 7.7 11.7 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Hid1 PF12722.7 CDI77347.1 - 2.5 6.1 15.4 2.9 5.9 15.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YABBY PF04690.13 CDI77347.1 - 2.6 8.6 13.0 3.7 8.1 13.0 1.2 1 0 0 1 1 1 0 YABBY protein SpoIIP PF07454.11 CDI77347.1 - 2.6 7.4 20.0 3.7 6.9 20.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM60A PF15396.6 CDI77347.1 - 2.8 7.9 13.2 3.5 7.6 13.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF4407 PF14362.6 CDI77347.1 - 3 7.1 18.2 3.5 6.9 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med15 PF09606.10 CDI77347.1 - 3 6.4 35.5 4.5 5.8 35.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Asp-B-Hydro_N PF05279.11 CDI77347.1 - 4.9 7.2 15.8 6.1 6.8 15.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3533 PF12051.8 CDI77347.1 - 5 6.0 11.3 6.5 5.6 11.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) HCO3_cotransp PF00955.21 CDI77347.1 - 5.2 5.8 7.9 6.2 5.5 7.9 1.1 1 0 0 1 1 1 0 HCO3- transporter family Hydin_ADK PF17213.3 CDI77347.1 - 6.6 7.0 13.0 11 6.2 13.0 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain LMBR1 PF04791.16 CDI77347.1 - 6.8 5.5 8.2 7.1 5.4 8.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein G0-G1_switch_2 PF15103.6 CDI77347.1 - 9.3 6.7 12.6 16 6.0 12.6 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 V-ATPase_C PF03223.15 CDI77348.1 - 7.5e-91 305.3 0.0 8.2e-91 305.2 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DEAD PF00270.29 CDI77349.1 - 1.7e-50 171.2 0.0 2.9e-50 170.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI77349.1 - 7.5e-34 116.4 0.0 2.2e-33 114.9 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain UTP25 PF06862.12 CDI77349.1 - 0.0059 15.4 0.0 0.017 13.9 0.0 1.8 2 1 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 CDI77349.1 - 0.063 13.6 0.0 1.9 8.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain SUIM_assoc PF16619.5 CDI77349.1 - 0.34 11.0 7.2 0.83 9.8 7.2 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CDV3 PF15359.6 CDI77349.1 - 0.48 10.9 4.8 0.35 11.4 2.3 1.8 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Ssl1 PF04056.14 CDI77351.1 - 3.3e-28 98.8 0.1 1.2e-27 97.0 0.1 1.9 1 1 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 CDI77351.1 - 9.8e-06 26.2 2.5 1.1e-05 26.1 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain TFIIA PF03153.13 CDI77351.1 - 0.0003 20.9 21.7 0.00035 20.7 21.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI77351.1 - 0.033 14.6 7.4 0.045 14.1 7.4 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CDI77351.1 - 0.1 11.6 8.1 0.12 11.3 8.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ndc1_Nup PF09531.10 CDI77351.1 - 0.11 11.2 6.0 0.11 11.2 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAT1 PF06391.13 CDI77351.1 - 0.13 12.0 16.5 0.21 11.4 16.5 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Sec62 PF03839.16 CDI77351.1 - 0.55 9.7 8.4 0.67 9.4 8.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Orf78 PF06024.12 CDI77351.1 - 0.6 10.5 6.1 1.1 9.6 6.1 1.5 1 0 0 1 1 1 0 Orf78 (ac78) FCP1_C PF09309.10 CDI77351.1 - 0.75 9.6 12.6 1.1 9.1 12.6 1.2 1 0 0 1 1 1 0 FCP1, C-terminal DUF702 PF05142.12 CDI77351.1 - 0.86 10.1 9.7 1.4 9.4 9.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Tfb4 PF03850.14 CDI77351.1 - 1 8.8 11.1 2.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Transcription factor Tfb4 TMEM51 PF15345.6 CDI77351.1 - 1.4 8.7 11.5 1.8 8.4 11.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 SLC12 PF03522.15 CDI77351.1 - 2.6 7.0 11.4 3.1 6.7 11.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CIAPIN1 PF05093.13 CDI77351.1 - 2.8 8.5 7.4 9.1 6.9 7.4 1.9 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis SpoIIP PF07454.11 CDI77351.1 - 3.3 7.1 10.8 4.4 6.7 10.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2722 PF10846.8 CDI77351.1 - 3.9 6.3 31.6 5.8 5.7 31.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI77351.1 - 5.2 5.7 14.7 6.8 5.3 14.7 1.2 1 0 0 1 1 1 0 Presenilin MPM1 PF17234.2 CDI77351.1 - 5.7 7.2 14.5 9.7 6.4 14.5 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 EIIBC-GUT_N PF03612.14 CDI77351.1 - 6 6.6 12.7 9.9 5.9 12.7 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Connexin PF00029.19 CDI77351.1 - 7.3 6.3 6.4 11 5.8 6.4 1.3 1 0 0 1 1 1 0 Connexin Spt20 PF12090.8 CDI77351.1 - 8.6 5.9 41.6 81 2.7 41.5 2.0 2 0 0 2 2 2 0 Spt20 family PAP_central PF04928.17 CDI77351.1 - 9.1 5.2 9.8 13 4.6 9.8 1.2 1 0 0 1 1 1 0 Poly(A) polymerase central domain Hid1 PF12722.7 CDI77351.1 - 9.1 4.3 10.2 10 4.1 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PepSY_TM_like_2 PF16357.5 CDI77351.1 - 9.2 6.2 8.2 14 5.5 8.2 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like Adaptin_N PF01602.20 CDI77352.1 - 1.5e-43 149.2 0.0 1.5e-43 149.2 0.0 1.8 2 0 0 2 2 1 1 Adaptin N terminal region B2-adapt-app_C PF09066.10 CDI77352.1 - 2.3e-12 47.0 0.2 2.3e-12 47.0 0.2 2.9 2 1 1 3 3 1 1 Beta2-adaptin appendage, C-terminal sub-domain Lin-8 PF03353.15 CDI77352.1 - 2e-05 24.3 18.8 0.01 15.5 8.0 2.1 2 0 0 2 2 2 2 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI77352.1 - 0.00015 21.9 37.0 0.031 14.3 24.1 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI77352.1 - 0.00073 19.8 12.0 0.026 14.7 5.0 2.3 2 0 0 2 2 2 2 DDHD domain Serinc PF03348.15 CDI77352.1 - 0.0011 18.0 5.3 0.028 13.4 1.3 2.2 2 0 0 2 2 2 1 Serine incorporator (Serinc) CSG2 PF16965.5 CDI77352.1 - 0.0023 16.9 3.4 0.0023 16.9 3.4 2.1 2 0 0 2 2 2 1 Ceramide synthase regulator EBP50_C PF09007.11 CDI77352.1 - 0.0038 18.2 18.7 0.14 13.2 5.7 2.4 2 0 0 2 2 2 2 EBP50, C-terminal Presenilin PF01080.17 CDI77352.1 - 0.0044 15.9 20.3 0.013 14.3 9.9 2.2 2 0 0 2 2 2 2 Presenilin Velvet PF11754.8 CDI77352.1 - 0.0049 16.8 11.5 0.012 15.6 4.2 2.3 2 0 0 2 2 2 1 Velvet factor SARAF PF06682.12 CDI77352.1 - 0.0082 15.8 11.2 0.034 13.8 3.2 2.2 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis EOS1 PF12326.8 CDI77352.1 - 0.018 15.0 7.9 0.1 12.5 3.7 2.4 2 0 0 2 2 2 0 N-glycosylation protein HEAT_2 PF13646.6 CDI77352.1 - 0.019 15.3 0.5 0.94 9.9 0.3 3.0 1 1 1 2 2 2 0 HEAT repeats BORG_CEP PF14957.6 CDI77352.1 - 0.025 15.7 11.6 0.31 12.2 2.2 2.4 2 0 0 2 2 2 0 Cdc42 effector DUF3295 PF11702.8 CDI77352.1 - 0.027 13.9 23.0 0.017 14.5 7.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) RR_TM4-6 PF06459.12 CDI77352.1 - 0.035 13.9 14.5 0.11 12.3 7.7 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 7tm_1 PF00001.21 CDI77352.1 - 0.047 13.0 1.0 0.11 11.8 0.4 1.9 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF572 PF04502.13 CDI77352.1 - 0.058 13.0 16.7 0.6 9.7 1.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) LAP1C PF05609.12 CDI77352.1 - 0.074 12.1 21.9 0.037 13.1 11.4 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) SID-1_RNA_chan PF13965.6 CDI77352.1 - 0.11 10.9 7.3 0.21 10.0 3.1 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 TCP PF03634.13 CDI77352.1 - 0.21 12.1 23.1 0.61 10.6 12.6 2.3 2 0 0 2 2 2 0 TCP family transcription factor MMR1 PF08505.10 CDI77352.1 - 0.25 11.6 25.5 1.3 9.3 3.5 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Exonuc_VII_L PF02601.15 CDI77352.1 - 0.27 10.8 16.4 2.5 7.6 10.1 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit CCDC53 PF10152.9 CDI77352.1 - 0.27 11.6 19.8 0.76 10.2 10.8 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex CCSAP PF15748.5 CDI77352.1 - 0.37 10.9 23.2 0.86 9.7 11.0 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SURF6 PF04935.12 CDI77352.1 - 0.4 10.4 27.6 0.84 9.4 16.2 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 DUF3801 PF12687.7 CDI77352.1 - 0.46 10.5 22.9 1.1 9.3 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) DUF3371 PF11851.8 CDI77352.1 - 0.47 11.6 21.4 0.55 11.3 9.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) Ctr PF04145.15 CDI77352.1 - 0.52 10.9 12.3 2 9.0 5.6 2.5 2 0 0 2 2 2 0 Ctr copper transporter family DUF913 PF06025.12 CDI77352.1 - 0.71 8.8 11.8 0.22 10.4 3.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF1387 PF07139.11 CDI77352.1 - 0.76 9.4 25.0 0.18 11.5 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) RPOL_N PF14700.6 CDI77352.1 - 0.77 9.1 21.0 1.4 8.3 14.5 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal GAGA_bind PF06217.12 CDI77352.1 - 0.95 9.7 14.4 0.9 9.8 8.2 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family DUF853 PF05872.12 CDI77352.1 - 1 7.8 15.8 7 5.1 0.0 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) Neur_chan_memb PF02932.16 CDI77352.1 - 1.1 9.3 16.2 5.9 6.9 0.3 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Apt1 PF10351.9 CDI77352.1 - 1.1 8.0 17.1 0.39 9.5 3.1 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain EPL1 PF10513.9 CDI77352.1 - 1.2 9.5 20.6 2 8.8 10.7 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Connexin PF00029.19 CDI77352.1 - 1.2 8.8 13.9 0.24 11.1 6.2 2.2 2 0 0 2 2 2 0 Connexin RNA_pol_Rpc4 PF05132.14 CDI77352.1 - 1.5 9.3 18.5 0.61 10.5 7.6 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Paf1 PF03985.13 CDI77352.1 - 1.6 7.7 24.5 0.22 10.5 9.6 2.1 2 0 0 2 2 2 0 Paf1 SpoIIP PF07454.11 CDI77352.1 - 1.8 8.0 19.2 1.2 8.5 10.7 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) GPCR_chapero_1 PF11904.8 CDI77352.1 - 2.2 7.6 11.0 1.7 8.0 5.0 2.2 2 0 0 2 2 2 0 GPCR-chaperone Pex14_N PF04695.13 CDI77352.1 - 2.3 8.9 31.3 0.56 10.8 17.0 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BAF1_ABF1 PF04684.13 CDI77352.1 - 2.4 7.1 19.4 4.4 6.2 12.7 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor SR-25 PF10500.9 CDI77352.1 - 2.8 7.5 28.7 0.3 10.7 9.6 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4407 PF14362.6 CDI77352.1 - 2.9 7.2 20.9 4.9 6.4 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PPP4R2 PF09184.11 CDI77352.1 - 2.9 7.4 11.5 1.6 8.2 3.7 2.2 2 0 0 2 2 2 0 PPP4R2 SPX PF03105.19 CDI77352.1 - 3.1 7.6 23.3 1.5 8.7 6.3 2.1 2 0 0 2 2 2 0 SPX domain PepSY_TM PF03929.16 CDI77352.1 - 3.7 7.1 10.2 9.4 5.8 4.0 2.3 2 0 0 2 2 2 0 PepSY-associated TM region DUF4820 PF16091.5 CDI77352.1 - 4.4 6.6 20.2 3.9 6.8 10.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) eIF-3_zeta PF05091.12 CDI77352.1 - 4.4 6.2 25.9 1.5 7.7 15.3 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2464 PF10240.9 CDI77352.1 - 4.7 6.7 14.6 6.8 6.2 7.1 2.2 2 0 0 2 2 2 0 Multivesicular body subunit 12 Otopetrin PF03189.13 CDI77352.1 - 5 5.8 10.7 0.69 8.7 3.8 2.0 2 0 0 2 2 2 0 Otopetrin GREB1 PF15782.5 CDI77352.1 - 5.7 3.9 18.9 0.5 7.4 6.8 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer RP-C_C PF11800.8 CDI77352.1 - 6 6.9 21.6 0.29 11.2 8.3 2.5 2 0 0 2 2 2 0 Replication protein C C-terminal region V_ATPase_I PF01496.19 CDI77352.1 - 6.3 4.6 20.3 0.81 7.5 10.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF3807 PF12720.7 CDI77352.1 - 6.5 7.0 32.0 1.2 9.4 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) ALMT PF11744.8 CDI77352.1 - 6.8 5.4 17.2 0.64 8.8 7.7 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter NEMP PF10225.9 CDI77352.1 - 6.9 6.3 11.2 8.4 6.0 0.5 2.5 2 0 0 2 2 2 0 NEMP family Zip PF02535.22 CDI77352.1 - 7.4 5.7 6.7 4.3 6.5 1.6 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Scs3p PF10261.9 CDI77352.1 - 7.6 6.0 9.7 0.61 9.5 3.8 1.9 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM PIP5K PF01504.18 CDI77352.1 - 7.7 5.7 14.7 1 8.5 6.6 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Peroxin-13_N PF04088.13 CDI77352.1 - 7.7 6.8 14.8 16 5.7 9.7 2.8 2 1 0 2 2 2 0 Peroxin 13, N-terminal region DUF2052 PF09747.9 CDI77352.1 - 7.9 6.6 21.4 13 5.9 0.8 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CLN3 PF02487.17 CDI77352.1 - 8.9 5.2 15.5 0.25 10.4 5.3 2.2 2 0 0 2 2 2 0 CLN3 protein Hydin_ADK PF17213.3 CDI77352.1 - 9.5 6.4 27.6 0.62 10.3 7.4 2.7 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain Adaptin_N PF01602.20 CDI77353.1 - 8.3e-50 169.8 5.5 5.6e-26 91.2 0.5 2.0 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 CDI77353.1 - 8.1e-34 117.0 1.6 1.1e-33 116.6 0.4 1.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CDI77353.1 - 4.4e-10 38.9 0.9 0.0028 17.7 0.1 3.9 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 CDI77353.1 - 1.3e-09 38.4 3.1 1.2e-06 28.8 0.2 3.1 3 2 1 4 4 4 2 HEAT repeats CLASP_N PF12348.8 CDI77353.1 - 0.034 13.7 0.4 1.6 8.2 0.0 2.6 2 1 1 3 3 3 0 CLASP N terminal RTP1_C1 PF10363.9 CDI77353.1 - 0.077 13.2 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 SIN1_PH PF16979.5 CDI77353.1 - 0.086 13.1 0.0 0.3 11.4 0.0 1.8 1 1 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology HEAT_EZ PF13513.6 CDI77353.1 - 2.5 8.7 9.7 1.9 9.1 0.1 3.8 3 1 0 3 3 3 0 HEAT-like repeat DUF5523 PF17661.1 CDI77354.1 - 0.0041 16.8 14.7 0.0041 16.8 14.7 2.8 4 0 0 4 4 4 1 Family of unknown function (DUF5523) GEMIN8 PF15348.6 CDI77354.1 - 0.0074 16.6 13.3 0.0074 16.6 13.3 3.0 4 0 0 4 4 4 1 Gemini of Cajal bodies-associated protein 8 NARP1 PF12569.8 CDI77354.1 - 1.4 7.8 18.5 2.5 6.9 18.5 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SID-1_RNA_chan PF13965.6 CDI77354.1 - 1.6 7.0 15.4 0.042 12.3 3.0 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Cellulose_synt PF03552.14 CDI77354.1 - 1.9 6.8 7.6 3.7 5.9 7.6 1.4 1 0 0 1 1 1 0 Cellulose synthase BUD22 PF09073.10 CDI77354.1 - 5.3 6.3 45.0 22 4.3 44.9 2.1 1 1 0 1 1 1 0 BUD22 DUF4695 PF15766.5 CDI77355.1 - 0.48 10.7 2.9 0.57 10.4 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4695) Prefoldin PF02996.17 CDI77355.1 - 1.1 9.2 3.5 26 4.8 0.0 2.7 2 1 1 3 3 3 0 Prefoldin subunit Mog1 PF04603.12 CDI77356.1 - 2.2e-24 86.4 0.0 2.9e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Ran-interacting Mog1 protein ubiquitin PF00240.23 CDI77358.1 - 1.3e-11 44.1 0.0 1.6e-07 30.9 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 CDI77358.1 - 0.0029 17.4 0.2 0.0074 16.1 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CDI77358.1 - 0.0044 17.0 0.5 0.71 10.0 0.1 3.3 2 2 0 2 2 2 1 Ubiquitin-like domain YukD PF08817.10 CDI77358.1 - 0.064 14.0 0.1 0.62 10.8 0.0 2.2 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD MSC PF09402.10 CDI77358.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain UN_NPL4 PF11543.8 CDI77358.1 - 0.17 12.4 0.0 0.63 10.6 0.0 2.0 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 IMCp PF12314.8 CDI77359.1 - 1.1e-25 89.7 50.0 2.7e-25 88.5 17.1 3.6 2 1 2 4 4 4 3 Inner membrane complex protein Clathrin PF00637.20 CDI77360.1 - 2e-06 27.8 0.4 6.8e-06 26.0 0.1 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.8 CDI77360.1 - 0.00014 22.1 0.1 0.00033 20.8 0.1 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal AsnA PF03590.15 CDI77361.1 - 1.2e-84 283.6 0.0 1.5e-84 283.3 0.0 1.1 1 0 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.20 CDI77361.1 - 0.17 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Dabb PF07876.12 CDI77362.1 - 2.5e-21 76.1 0.4 2.9e-21 75.9 0.4 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Ribosomal_L24e PF01246.20 CDI77363.1 - 2.4e-24 85.3 0.6 5.7e-24 84.1 0.6 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e DUF775 PF05603.12 CDI77363.1 - 0.024 14.2 0.2 0.027 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Trigger_C PF05698.14 CDI77364.1 - 2.9e-12 46.9 17.6 2.9e-12 46.9 17.6 1.7 2 0 0 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus EXS PF03124.14 CDI77365.1 - 7.4e-09 35.4 0.2 8.8e-09 35.1 0.2 1.1 1 0 0 1 1 1 1 EXS family 2-oxoacid_dh PF00198.23 CDI77366.1 - 4.8e-67 225.8 0.0 6.1e-67 225.5 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDI77366.1 - 4.7e-19 68.0 1.0 8.5e-19 67.2 1.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CDI77366.1 - 1.6e-16 60.3 2.7 9.4e-16 57.9 1.3 2.6 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CDI77366.1 - 8.8e-07 28.7 0.1 3.4e-06 26.8 0.2 2.0 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDI77366.1 - 4.1e-05 22.9 0.0 9.9e-05 21.6 0.0 1.6 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 CDI77366.1 - 0.038 13.9 0.1 0.076 12.9 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein PTS_EIIA_1 PF00358.20 CDI77366.1 - 0.11 12.2 0.0 0.47 10.2 0.0 1.9 1 1 1 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 DUF2428 PF10350.9 CDI77368.1 - 3.3e-12 46.3 3.6 3.3e-12 46.3 3.6 5.1 4 1 0 4 4 4 2 Putative death-receptor fusion protein (DUF2428) Sec23_trunk PF04811.15 CDI77369.1 - 1.5e-55 188.5 0.0 2.1e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDI77369.1 - 1.2e-30 106.1 0.1 1.7e-29 102.4 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CDI77369.1 - 3.7e-24 84.5 0.5 7.1e-24 83.6 0.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDI77369.1 - 1.4e-13 50.6 3.2 2.9e-13 49.6 3.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CDI77369.1 - 2.6e-12 46.5 0.0 7.8e-12 44.9 0.0 1.8 1 1 0 1 1 1 1 Gelsolin repeat Rad51 PF08423.11 CDI77370.1 - 1.3e-113 378.5 0.3 3.4e-59 200.2 0.0 2.5 3 0 0 3 3 3 2 Rad51 RecA PF00154.21 CDI77370.1 - 1.7e-07 31.0 0.0 0.00036 20.1 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_25 PF13481.6 CDI77370.1 - 2.6e-06 27.2 0.0 3.8e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CDI77370.1 - 0.00034 20.0 0.0 0.0016 17.8 0.0 2.0 2 0 0 2 2 2 1 KaiC HHH_5 PF14520.6 CDI77370.1 - 0.0016 19.0 0.3 0.0047 17.5 0.3 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain PP2C PF00481.21 CDI77371.1 - 8.6e-47 159.9 0.0 8.6e-47 159.9 0.0 3.2 2 1 1 4 4 4 1 Protein phosphatase 2C Utp14 PF04615.13 CDI77371.1 - 0.051 12.2 45.6 0.081 11.5 45.6 1.3 1 0 0 1 1 1 0 Utp14 protein MAP65_ASE1 PF03999.12 CDI77371.1 - 0.75 8.4 24.3 0.026 13.3 18.0 1.7 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) ubiquitin PF00240.23 CDI77374.1 - 0.014 15.2 0.0 0.031 14.0 0.0 1.5 2 0 0 2 2 2 0 Ubiquitin family DUF4131 PF13567.6 CDI77374.1 - 0.25 11.0 3.7 0.48 10.0 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Coatomer_WDAD PF04053.14 CDI77375.1 - 0.00015 21.0 11.1 0.0022 17.1 0.6 4.5 5 0 0 5 5 5 2 Coatomer WD associated region TPR_1 PF00515.28 CDI77375.1 - 0.089 12.7 0.7 44 4.1 0.1 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI77375.1 - 0.47 10.7 18.7 1.7 8.9 0.3 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat DZR PF12773.7 CDI77375.1 - 4.3 7.4 10.9 2.8 8.1 0.4 3.6 3 0 0 3 3 3 0 Double zinc ribbon TPR_7 PF13176.6 CDI77375.1 - 9 6.6 7.5 7.8 6.8 0.3 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat RMI1_N PF08585.12 CDI77376.1 - 1.5e-14 54.3 0.0 1.7e-13 50.8 0.0 2.2 1 1 0 1 1 1 1 RecQ mediated genome instability protein DUF1926 PF09095.11 CDI77376.1 - 0.2 11.2 0.0 0.29 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1926) Voldacs PF03517.13 CDI77377.1 - 4.5e-13 49.5 0.3 5.7e-13 49.2 0.3 1.1 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Lipase_3 PF01764.25 CDI77378.1 - 5.1e-13 49.1 0.0 9e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Phage_Coat_A PF05357.13 CDI77381.1 - 0.28 11.0 1.5 18 5.2 0.0 2.4 2 0 0 2 2 2 0 Phage Coat Protein A 4HB_MCP_1 PF12729.7 CDI77381.1 - 1.3 8.6 7.6 2 7.9 4.9 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction LCD1 PF09798.9 CDI77381.1 - 1.3 7.4 11.1 1.8 6.9 11.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein BRE1 PF08647.11 CDI77381.1 - 2.5 8.2 22.1 0.12 12.5 4.6 3.5 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase SR-25 PF10500.9 CDI77382.1 - 0.016 14.9 32.6 0.024 14.3 32.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDI77382.1 - 0.22 11.2 20.5 0.3 10.8 20.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Nucleo_P87 PF07267.11 CDI77382.1 - 0.26 10.1 12.7 0.3 9.9 12.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Zip PF02535.22 CDI77382.1 - 0.32 10.2 6.5 0.35 10.0 6.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter GAGA_bind PF06217.12 CDI77382.1 - 0.33 11.2 13.4 0.42 10.9 13.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family EOS1 PF12326.8 CDI77382.1 - 0.52 10.2 7.3 0.73 9.7 7.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF4407 PF14362.6 CDI77382.1 - 0.96 8.7 7.1 1.1 8.6 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 CDI77382.1 - 1.1 7.5 21.9 1.3 7.2 21.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI77382.1 - 1.2 9.2 7.9 1.4 8.9 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MID_MedPIWI PF18296.1 CDI77382.1 - 1.4 8.6 10.6 1.8 8.3 10.6 1.1 1 0 0 1 1 1 0 MID domain of medPIWI RR_TM4-6 PF06459.12 CDI77382.1 - 1.6 8.5 18.8 2 8.2 18.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_pol_Rpc4 PF05132.14 CDI77382.1 - 2.4 8.6 11.2 3.7 8.0 11.2 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_11 PF13086.6 CDI77382.1 - 3 7.5 14.4 3.9 7.2 14.4 1.2 1 0 0 1 1 1 0 AAA domain Med19 PF10278.9 CDI77382.1 - 3.9 7.4 32.9 1.1 9.2 29.8 1.5 1 1 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF913 PF06025.12 CDI77382.1 - 4.1 6.3 9.1 4.8 6.1 9.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Dsh_C PF12316.8 CDI77382.1 - 5.5 7.3 12.2 7.2 7.0 12.2 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Vfa1 PF08432.10 CDI77382.1 - 6.2 7.1 28.1 11 6.3 28.1 1.4 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Glyco_transf_43 PF03360.16 CDI77383.1 - 0.15 11.8 4.0 0.3 10.9 4.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 43 V_ATPase_I PF01496.19 CDI77383.1 - 0.38 8.6 10.7 0.36 8.7 8.7 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family MAT1 PF06391.13 CDI77383.1 - 0.6 9.9 22.8 0.065 13.0 17.7 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Membralin PF09746.9 CDI77383.1 - 0.77 8.7 6.0 1.2 8.1 6.0 1.4 1 0 0 1 1 1 0 Tumour-associated protein LMBR1 PF04791.16 CDI77383.1 - 6.5 5.5 6.7 0.8 8.5 2.4 1.6 2 0 0 2 2 2 0 LMBR1-like membrane protein AP3D1 PF06375.11 CDI77384.1 - 0.01 16.1 4.0 0.01 16.1 4.0 2.4 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 SUIM_assoc PF16619.5 CDI77384.1 - 2.9 8.0 36.2 2.2 8.4 14.2 4.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 SWIRM-assoc_2 PF16496.5 CDI77384.1 - 3.9 6.2 11.4 0.23 10.3 5.8 1.8 2 0 0 2 2 2 0 SWIRM-associated domain at the N-terminal SIN1 PF05422.12 CDI77384.1 - 5.3 7.6 17.9 1.6 9.3 7.3 3.2 3 0 0 3 3 3 0 Stress-activated map kinase interacting protein 1 (SIN1) CDC27 PF09507.10 CDI77384.1 - 5.5 6.3 44.4 14 5.0 43.9 2.1 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 AP2 PF00847.20 CDI77387.1 - 0.00015 21.9 0.6 0.00015 21.9 0.6 4.0 4 0 0 4 4 4 1 AP2 domain Apt1 PF10351.9 CDI77388.1 - 0.49 9.2 19.0 0.57 9.0 19.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI77388.1 - 0.97 8.1 6.0 1.1 7.9 6.0 1.1 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 CDI77388.1 - 1.9 8.3 19.0 2.3 8.0 19.0 1.1 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 CDI77388.1 - 2.1 5.4 13.3 2.3 5.2 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Raftlin PF15250.6 CDI77388.1 - 4.6 5.9 7.6 5.6 5.6 7.6 1.0 1 0 0 1 1 1 0 Raftlin AAA_16 PF13191.6 CDI77390.1 - 4.7e-06 27.1 2.1 4.7e-06 27.1 2.1 3.5 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 CDI77390.1 - 1.9e-05 25.0 0.8 5e-05 23.6 0.2 2.0 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CDI77390.1 - 0.007 15.8 0.1 0.048 13.1 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein ORC4_C PF14629.6 CDI77390.1 - 0.02 14.3 0.1 0.047 13.1 0.0 1.7 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus T2SSE PF00437.20 CDI77390.1 - 0.044 12.8 0.0 0.088 11.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2890 PF11081.8 CDI77390.1 - 0.44 10.6 5.1 0.55 10.3 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Troponin PF00992.20 CDI77390.1 - 1.4 9.2 7.0 0.32 11.3 1.6 2.2 2 0 0 2 2 2 0 Troponin YchF-GTPase_C PF06071.13 CDI77391.1 - 2.2e-30 104.7 0.4 8.1e-30 102.9 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CDI77391.1 - 6.3e-21 74.6 0.0 4.5e-20 71.8 0.0 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI77391.1 - 3.6e-06 26.6 0.0 1.2e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B GvpL_GvpF PF06386.11 CDI77391.1 - 0.097 12.6 7.2 0.095 12.6 0.7 2.1 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF SUIM_assoc PF16619.5 CDI77391.1 - 0.4 10.8 12.3 0.033 14.3 6.5 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 CRIC_ras_sig PF10534.9 CDI77391.1 - 1.1 9.5 6.6 0.18 12.0 0.3 2.3 2 0 0 2 2 2 0 Connector enhancer of kinase suppressor of ras Spt20 PF12090.8 CDI77391.1 - 3.4 7.2 10.5 0.12 12.0 4.1 1.7 2 0 0 2 2 2 0 Spt20 family Pkinase PF00069.25 CDI77392.1 - 2.9e-73 246.5 0.0 4.6e-73 245.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77392.1 - 4.7e-36 124.4 0.0 7.9e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDI77392.1 - 8.4e-05 22.6 0.0 8.4e-05 22.6 0.0 3.0 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDI77392.1 - 0.00022 20.7 0.2 0.001 18.5 0.0 2.1 2 1 1 3 3 3 1 Kinase-like Kdo PF06293.14 CDI77392.1 - 0.0012 18.3 0.1 0.003 16.9 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDI77392.1 - 0.0078 15.2 5.4 0.0087 15.0 0.1 2.6 2 0 0 2 2 2 1 Haspin like kinase domain Choline_kinase PF01633.20 CDI77392.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Atg14 PF10186.9 CDI77395.1 - 0.0036 16.4 7.6 0.0036 16.4 7.6 3.1 1 1 2 3 3 3 2 Vacuolar sorting 38 and autophagy-related subunit 14 WD40_alt PF14077.6 CDI77395.1 - 0.013 15.3 13.6 0.64 9.9 4.8 3.9 3 1 1 4 4 4 0 Alternative WD40 repeat motif DUF2808 PF10989.8 CDI77395.1 - 0.1 12.6 0.1 0.1 12.6 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2808) HIP1_clath_bdg PF16515.5 CDI77395.1 - 9.5 6.9 66.4 0.15 12.7 5.7 4.8 2 1 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 M16C_assoc PF08367.11 CDI77397.1 - 2.2e-25 89.2 0.0 4.5e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 CDI77397.1 - 2.8e-15 56.8 0.0 1.5e-12 47.9 0.0 3.4 2 2 1 3 3 3 2 Peptidase M16 inactive domain GST_C_2 PF13410.6 CDI77397.1 - 0.16 12.0 0.0 6.6 6.8 0.0 2.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain CTNNBL PF08216.11 CDI77399.1 - 2.5e-14 53.3 0.7 3.6e-14 52.8 0.7 1.2 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Herpes_U30 PF04523.13 CDI77399.1 - 0.09 10.7 0.2 0.11 10.4 0.2 1.1 1 0 0 1 1 1 0 Herpes virus tegument protein U30 RRM_occluded PF16842.5 CDI77399.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif SHS2_FTSA PF02491.20 CDI77399.1 - 0.28 11.6 1.3 1 9.8 0.4 2.0 1 1 1 2 2 2 0 SHS2 domain inserted in FTSA U3_snoRNA_assoc PF08297.11 CDI77400.1 - 0.0076 16.9 2.7 0.0091 16.7 2.7 1.1 1 0 0 1 1 1 1 U3 snoRNA associated DUF1151 PF06625.11 CDI77400.1 - 0.35 10.8 20.2 0.42 10.6 20.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) DUF2464 PF10240.9 CDI77400.1 - 0.59 9.6 7.1 0.64 9.5 7.1 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 RHH_8 PF17723.1 CDI77400.1 - 0.71 10.1 6.2 0.89 9.7 6.2 1.1 1 0 0 1 1 1 0 Ribbon-Helix-Helix transcriptional regulator family PRC2_HTH_1 PF18118.1 CDI77400.1 - 0.75 10.6 6.5 0.95 10.3 6.5 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Pex14_N PF04695.13 CDI77400.1 - 0.76 10.4 18.2 0.89 10.2 18.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF775 PF05603.12 CDI77400.1 - 2.3 7.7 13.4 2.8 7.4 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Connexin PF00029.19 CDI77400.1 - 3 7.6 6.7 3.3 7.4 6.7 1.1 1 0 0 1 1 1 0 Connexin EPL1 PF10513.9 CDI77400.1 - 3.2 8.1 12.6 3.8 7.9 12.6 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Gti1_Pac2 PF09729.9 CDI77400.1 - 3.3 7.8 9.3 3.5 7.7 9.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family OATP PF03137.20 CDI77400.1 - 4 5.6 5.4 4.5 5.5 5.4 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FAM60A PF15396.6 CDI77400.1 - 4.3 7.3 7.8 4.5 7.2 7.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.13 CDI77400.1 - 4.4 7.0 11.6 4.9 6.9 11.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Hydin_ADK PF17213.3 CDI77400.1 - 4.9 7.4 10.5 6 7.1 10.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Zip PF02535.22 CDI77400.1 - 5.1 6.2 5.7 5.6 6.1 5.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 CDI77400.1 - 5.1 6.5 8.3 5 6.6 8.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PAT1 PF09770.9 CDI77400.1 - 6.1 5.0 22.4 6 5.0 22.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF1980 PF09323.10 CDI77400.1 - 6.8 6.6 10.1 7.5 6.4 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Presenilin PF01080.17 CDI77400.1 - 6.9 5.3 13.3 7.6 5.2 13.3 1.0 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 CDI77400.1 - 7 5.4 9.6 6.9 5.4 9.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PepSY_TM PF03929.16 CDI77400.1 - 7.9 6.1 7.1 8.8 5.9 7.1 1.1 1 0 0 1 1 1 0 PepSY-associated TM region FliP PF00813.20 CDI77400.1 - 8.4 6.2 6.9 9.9 6.0 6.9 1.0 1 0 0 1 1 1 0 FliP family CSG2 PF16965.5 CDI77400.1 - 8.8 5.2 7.6 9.9 5.0 7.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Kei1 PF08552.11 CDI77400.1 - 9.4 6.1 7.9 11 5.9 7.9 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Spt20 PF12090.8 CDI77401.1 - 0.01 15.5 6.5 0.01 15.5 6.5 2.1 2 0 0 2 2 2 0 Spt20 family CHCH PF06747.13 CDI77401.1 - 0.062 13.5 5.8 0.39 10.9 0.1 2.4 1 1 1 2 2 2 0 CHCH domain SPX PF03105.19 CDI77401.1 - 0.12 12.3 18.0 0.18 11.7 18.0 1.3 1 0 0 1 1 1 0 SPX domain Rubella_E2 PF05749.11 CDI77401.1 - 0.57 9.6 5.9 0.18 11.3 0.6 2.0 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 TFIIA PF03153.13 CDI77401.1 - 5.7 6.8 18.3 12 5.8 18.4 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI77402.1 - 0.022 15.0 0.0 0.022 15.0 0.0 15.5 6 4 4 11 11 11 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI77404.1 - 9.2e-06 24.9 19.3 0.0098 14.9 0.2 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) Hira PF07569.11 CDI77404.1 - 0.0074 16.0 0.0 0.0074 16.0 0.0 2.3 2 0 0 2 2 2 1 TUP1-like enhancer of split COX14 PF14880.6 CDI77404.1 - 0.018 14.9 0.7 0.018 14.9 0.7 2.8 3 0 0 3 3 3 0 Cytochrome oxidase c assembly BSMAP PF12280.8 CDI77404.1 - 0.062 13.5 0.3 0.062 13.5 0.3 2.7 3 0 0 3 3 3 0 Brain specific membrane anchored protein RAB3GAP2_N PF14655.6 CDI77404.1 - 0.22 10.7 11.1 1.1 8.4 0.1 2.9 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIIA PF03153.13 CDI77404.1 - 0.52 10.2 63.9 0.096 12.7 7.3 3.3 2 1 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit EIIBC-GUT_N PF03612.14 CDI77404.1 - 1.7 8.4 8.1 14 5.4 1.9 2.9 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus GT87 PF09594.10 CDI77404.1 - 3.5 7.3 32.9 0.061 13.0 5.2 4.2 3 1 0 3 3 3 0 Glycosyltransferase family 87 SR-25 PF10500.9 CDI77405.1 - 7.9e-05 22.4 57.9 0.0064 16.1 25.2 2.6 1 1 2 3 3 3 2 Nuclear RNA-splicing-associated protein BCIP PF13862.6 CDI77405.1 - 0.72 9.6 13.0 0.18 11.5 2.3 2.4 2 0 0 2 2 2 0 p21-C-terminal region-binding protein AAA_23 PF13476.6 CDI77405.1 - 1.1 9.7 19.3 0.19 12.2 1.7 2.3 2 0 0 2 2 2 0 AAA domain DUF4278 PF14105.6 CDI77405.1 - 5.5 7.5 10.3 0.32 11.4 3.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4278) rRNA_processing PF08524.11 CDI77405.1 - 5.8 6.9 47.2 0.29 11.1 15.0 2.8 3 0 0 3 3 3 0 rRNA processing Sad1_UNC PF07738.13 CDI77407.1 - 1.3e-21 77.0 0.0 2e-11 44.0 0.0 2.6 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal Tweety PF04906.13 CDI77407.1 - 0.019 13.7 0.9 0.077 11.7 0.0 1.9 1 1 1 2 2 2 0 Tweety LAGLIDADG_2 PF03161.13 CDI77407.1 - 0.031 14.3 0.0 0.031 14.3 0.0 2.5 3 0 0 3 3 3 0 LAGLIDADG DNA endonuclease family Med15 PF09606.10 CDI77407.1 - 0.039 12.6 41.9 0.0039 16.0 25.5 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1091 PF06477.13 CDI77407.1 - 0.083 13.4 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) 7tm_7 PF08395.12 CDI77407.1 - 1.2 8.2 4.5 2.3 7.3 4.5 1.4 1 0 0 1 1 1 0 7tm Chemosensory receptor DUF2408 PF10303.9 CDI77407.1 - 1.4 9.5 14.7 0.27 11.8 8.8 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) Prominin PF05478.11 CDI77407.1 - 2.5 6.0 9.0 3.7 5.4 9.0 1.2 1 0 0 1 1 1 0 Prominin BAF1_ABF1 PF04684.13 CDI77407.1 - 4 6.4 20.0 0.52 9.3 10.2 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor UPF0242 PF06785.11 CDI77407.1 - 5.9 6.9 26.3 0.81 9.8 5.5 2.9 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus LRR_6 PF13516.6 CDI77408.1 - 4.7e-06 26.2 0.5 0.013 15.5 0.0 3.9 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 CDI77408.1 - 0.081 13.4 0.3 0.2 12.1 0.1 1.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDI77408.1 - 2 9.3 4.9 27 5.8 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat DUF4710 PF15828.5 CDI77409.1 - 0.034 14.3 1.1 0.034 14.3 1.1 4.3 4 1 0 5 5 5 0 Domain of unknown function (DUF4710) tRNA-synt_2 PF00152.20 CDI77412.1 - 6.8e-21 74.7 0.1 6e-20 71.6 0.0 2.7 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) Utp14 PF04615.13 CDI77412.1 - 3.1e-08 32.7 27.0 4.6e-07 28.8 27.1 2.7 1 1 0 1 1 1 1 Utp14 protein tRNA_anti-codon PF01336.25 CDI77412.1 - 0.0018 18.2 0.1 0.17 11.9 0.0 2.6 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain HATPase_c_5 PF14501.6 CDI77412.1 - 0.15 11.9 1.2 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 GHKL domain KASH PF10541.9 CDI77412.1 - 3.9 7.8 6.8 6.4 7.1 2.2 2.8 2 0 0 2 2 2 0 Nuclear envelope localisation domain Clathrin_lg_ch PF01086.17 CDI77413.1 - 0.00029 21.0 50.9 0.00074 19.6 50.6 2.0 1 1 0 1 1 1 1 Clathrin light chain NAD_binding_5 PF07994.12 CDI77413.1 - 5 6.4 16.0 0.53 9.6 6.7 2.2 1 1 0 2 2 2 0 Myo-inositol-1-phosphate synthase MCM PF00493.23 CDI77414.1 - 3.4e-79 265.1 0.0 5.8e-79 264.3 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDI77414.1 - 8.6e-25 87.0 0.5 8.6e-25 87.0 0.5 1.8 2 0 0 2 2 2 1 MCM AAA-lid domain MCM6_C PF18263.1 CDI77414.1 - 2.8e-11 43.6 0.2 2.2e-10 40.8 0.0 2.5 3 0 0 3 3 3 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 CDI77414.1 - 1.4e-05 24.6 0.0 4.4e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDI77414.1 - 0.0021 18.1 0.0 0.012 15.6 0.0 2.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDI77414.1 - 0.015 15.2 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2057 PF09829.9 CDI77414.1 - 4.3 7.4 11.2 24 5.0 6.4 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) MCM_N PF14551.6 CDI77415.1 - 6e-08 33.2 0.0 8.3e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 MCM N-terminal domain Pkinase PF00069.25 CDI77416.1 - 2.1e-13 50.2 0.0 3.4e-08 33.2 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 CDI77416.1 - 3.3e-10 39.7 0.0 0.0019 17.6 0.0 3.2 3 0 0 3 3 3 3 Kinase-like Pkinase_Tyr PF07714.17 CDI77416.1 - 0.00073 18.9 0.0 0.036 13.4 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pex14_N PF04695.13 CDI77416.1 - 0.13 12.9 16.4 0.12 13.0 4.3 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MOZ_SAS PF01853.18 CDI77418.1 - 5e-44 150.1 0.0 2.3e-26 92.5 0.0 2.2 2 0 0 2 2 2 2 MOZ/SAS family zf-MYST PF17772.1 CDI77418.1 - 5.6e-21 73.9 0.6 2.7e-20 71.7 0.4 2.1 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDI77418.1 - 1.6e-08 34.3 0.2 8.1e-07 28.8 0.1 2.6 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain TAF4 PF05236.14 CDI77418.1 - 0.089 12.5 0.0 0.089 12.5 0.0 3.8 3 2 0 3 3 3 0 Transcription initiation factor TFIID component TAF4 family DUF4590 PF15257.6 CDI77418.1 - 0.19 11.7 0.8 0.46 10.4 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4590) RskA PF10099.9 CDI77418.1 - 0.23 11.7 35.6 0.05 13.9 14.9 3.2 3 0 0 3 3 3 0 Anti-sigma-K factor rskA ParD_like PF11903.8 CDI77418.1 - 2.3 8.4 6.3 0.52 10.4 0.6 2.5 2 0 0 2 2 2 0 ParD-like antitoxin of type II bacterial toxin-antitoxin system Pkinase PF00069.25 CDI77419.1 - 1.7e-20 73.5 0.0 2.1e-19 69.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI77419.1 - 1.4e-10 40.9 0.0 1.6e-09 37.5 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI77419.1 - 3e-08 33.3 0.0 6.4e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase GYF PF02213.16 CDI77420.1 - 2.4e-12 46.3 0.0 4.8e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 GYF domain ORC5_C PF14630.6 CDI77422.1 - 0.09 12.3 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus Ribosomal_60s PF00428.19 CDI77422.1 - 1.3 9.6 9.0 0.51 11.0 4.9 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein MMR_HSR1 PF01926.23 CDI77425.1 - 3.7e-16 59.2 0.0 1.5e-13 50.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI77425.1 - 1.6e-08 34.3 0.0 4.9e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDI77425.1 - 8.5e-05 22.5 0.1 0.027 14.4 0.3 2.7 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDI77425.1 - 0.0008 19.5 4.5 0.6 10.1 0.1 3.6 3 1 0 4 4 4 2 Dynamin family AAA_16 PF13191.6 CDI77425.1 - 0.0033 17.8 0.4 0.0033 17.8 0.4 2.8 2 2 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 CDI77425.1 - 0.0067 16.0 0.0 0.2 11.2 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 CDI77425.1 - 0.064 12.2 0.4 0.14 11.1 0.4 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PDZ_3 PF17815.1 CDI77426.1 - 1.1e-27 96.6 0.2 7.5e-27 94.0 0.1 2.1 2 0 0 2 2 2 1 PDZ domain Trypsin_2 PF13365.6 CDI77426.1 - 2e-18 67.7 1.1 4.2e-18 66.7 1.1 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDI77426.1 - 8.3e-12 45.4 0.2 1.6e-11 44.4 0.2 1.4 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 CDI77426.1 - 2.6e-05 24.4 0.1 0.0002 21.6 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 CDI77426.1 - 0.0062 16.4 1.3 0.17 11.8 0.6 3.3 2 1 0 2 2 2 1 PDZ domain Peptidase_S46 PF10459.9 CDI77426.1 - 0.69 8.5 2.1 0.35 9.5 0.1 1.5 2 0 0 2 2 2 0 Peptidase S46 FAM91_C PF14648.6 CDI77427.1 - 8 5.2 9.7 16 4.2 9.7 1.4 1 0 0 1 1 1 0 FAM91 C-terminus DUF2870 PF11069.8 CDI77429.1 - 5.4e-22 78.0 0.2 1.4e-21 76.7 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) RNA_pol_Rpb4 PF03874.16 CDI77431.1 - 7.4e-06 26.3 0.0 1.5e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb4 CBF PF03914.17 CDI77433.1 - 4.9e-15 56.0 0.3 4.9e-15 56.0 0.3 2.8 2 1 0 2 2 2 1 CBF/Mak21 family DUF4834 PF16118.5 CDI77433.1 - 0.081 13.9 2.6 2.3 9.3 1.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) MAS20 PF02064.15 CDI77433.1 - 0.098 12.8 5.4 1 9.4 0.2 3.5 3 0 0 3 3 3 0 MAS20 protein import receptor PBP1_TM PF14812.6 CDI77433.1 - 0.27 11.6 1.7 1 9.8 0.4 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleo_P87 PF07267.11 CDI77433.1 - 1.1 8.0 6.6 2 7.2 6.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Sporozoite_P67 PF05642.11 CDI77433.1 - 3 5.8 9.9 0.97 7.4 5.1 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Glycos_transf_2 PF00535.26 CDI77434.1 - 1e-18 67.8 0.0 2e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDI77434.1 - 3.3e-08 33.8 0.1 1.1e-07 32.2 0.1 1.8 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 CDI77434.1 - 3.9e-05 23.7 0.0 7.2e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDI77434.1 - 0.0001 21.9 0.1 0.00022 20.8 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 CDI77434.1 - 0.00035 21.2 0.4 0.0015 19.2 0.0 2.3 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 CDI77434.1 - 0.0011 18.5 0.0 0.0032 17.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Secretin_N_2 PF07655.13 CDI77434.1 - 0.011 16.2 8.9 0.027 15.0 8.9 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain SR-25 PF10500.9 CDI77434.1 - 0.08 12.5 14.4 0.14 11.8 14.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RPA43_OB PF17875.1 CDI77434.1 - 0.085 13.5 1.0 0.4 11.3 0.0 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF4614 PF15391.6 CDI77434.1 - 0.12 12.3 4.4 0.21 11.6 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.9 CDI77434.1 - 3.2 6.2 8.2 5.5 5.4 8.2 1.3 1 0 0 1 1 1 0 Macoilin family eIF2A PF08662.11 CDI77435.1 - 4.9e-33 114.6 0.0 3.9e-30 105.2 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 CDI77435.1 - 0.036 14.3 0.0 0.27 11.6 0.0 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nudc_N PF14050.6 CDI77436.1 - 4e-20 71.6 0.0 8.1e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 CDI77436.1 - 0.0063 17.5 1.2 1.9 9.6 0.0 2.6 3 0 0 3 3 3 1 CS domain Dehydrin PF00257.19 CDI77436.1 - 0.013 16.1 8.8 0.013 16.1 8.8 3.0 3 0 0 3 3 3 0 Dehydrin tRNA_synt_1c_R2 PF04557.15 CDI77436.1 - 0.19 12.6 10.3 1.8 9.5 0.0 4.2 3 1 1 4 4 4 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 ODV-E18 PF10717.9 CDI77436.1 - 0.33 10.9 1.5 0.79 9.6 1.5 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 CNDH2_N PF06278.11 CDI77436.1 - 2.3 8.5 9.3 7.7 6.8 2.3 2.7 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal RAP1 PF07218.11 CDI77436.1 - 2.6 6.2 8.2 3.7 5.7 8.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Kelch_4 PF13418.6 CDI77437.1 - 1e-36 124.7 2.3 1.3e-08 34.7 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI77437.1 - 5.1e-33 112.7 1.4 6.1e-06 26.4 0.0 6.9 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI77437.1 - 1.4e-24 85.5 0.2 6.9e-06 25.9 0.0 6.9 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 CDI77437.1 - 6.1e-23 80.3 0.4 0.0025 18.1 0.4 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 CDI77437.1 - 7.5e-19 67.1 0.8 0.0059 16.2 0.3 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 CDI77437.1 - 1.1e-12 47.3 5.0 0.15 12.1 0.0 6.8 6 2 0 6 6 6 2 Kelch motif APG6_N PF17675.1 CDI77437.1 - 0.0003 21.3 10.2 0.00062 20.3 10.2 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region BLOC1_2 PF10046.9 CDI77437.1 - 0.0014 18.8 12.7 0.0022 18.2 11.6 1.8 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.8 CDI77437.1 - 0.0076 15.6 11.4 0.0076 15.6 11.4 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3450) DASH_Duo1 PF08651.10 CDI77437.1 - 0.0078 16.0 8.3 0.022 14.5 2.2 2.6 1 1 1 2 2 2 1 DASH complex subunit Duo1 ADIP PF11559.8 CDI77437.1 - 0.0079 16.3 10.2 0.0079 16.3 10.2 1.8 2 0 0 2 2 1 1 Afadin- and alpha -actinin-Binding TMPIT PF07851.13 CDI77437.1 - 0.01 15.1 9.6 0.018 14.3 9.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein Laminin_II PF06009.12 CDI77437.1 - 0.022 14.8 16.1 0.041 13.9 7.5 2.3 1 1 1 2 2 2 0 Laminin Domain II GAS PF13851.6 CDI77437.1 - 0.023 14.1 13.2 0.036 13.4 13.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Laminin_I PF06008.14 CDI77437.1 - 0.033 13.9 15.2 0.056 13.1 15.2 1.3 1 0 0 1 1 1 0 Laminin Domain I UPF0242 PF06785.11 CDI77437.1 - 0.034 14.3 8.0 0.054 13.6 8.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF489 PF04356.12 CDI77437.1 - 0.042 13.9 4.4 0.067 13.2 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) AAA_13 PF13166.6 CDI77437.1 - 0.042 12.5 10.0 0.072 11.7 10.0 1.3 1 0 0 1 1 1 0 AAA domain EzrA PF06160.12 CDI77437.1 - 0.05 11.8 10.2 0.071 11.3 10.2 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF1664 PF07889.12 CDI77437.1 - 0.063 13.3 11.6 0.24 11.4 11.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDI77437.1 - 0.076 13.3 13.1 0.15 12.4 5.9 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TMCO5 PF14992.6 CDI77437.1 - 0.087 12.4 8.8 0.13 11.8 8.8 1.2 1 0 0 1 1 1 0 TMCO5 family MCPsignal PF00015.21 CDI77437.1 - 0.098 12.5 13.3 0.1 12.4 11.3 2.0 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ran-binding PF05508.11 CDI77437.1 - 0.099 11.6 11.1 0.15 11.0 11.1 1.1 1 0 0 1 1 1 0 RanGTP-binding protein CCDC144C PF14915.6 CDI77437.1 - 0.11 11.6 13.8 0.19 10.8 13.8 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DASH_Hsk3 PF08227.11 CDI77437.1 - 0.13 12.7 5.4 1.6 9.1 3.8 2.5 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Spc7 PF08317.11 CDI77437.1 - 0.19 10.6 14.6 0.29 10.0 14.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Lebercilin PF15619.6 CDI77437.1 - 0.19 11.4 12.9 0.37 10.4 12.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF16 PF01519.16 CDI77437.1 - 0.25 11.8 8.8 0.48 10.9 8.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 FapA PF03961.13 CDI77437.1 - 0.27 9.8 6.5 0.39 9.3 6.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Vps53_N PF04100.12 CDI77437.1 - 0.31 10.0 10.0 0.48 9.3 10.0 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal CheZ PF04344.13 CDI77437.1 - 0.66 9.9 10.6 1.1 9.1 10.6 1.2 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Syntaxin-6_N PF09177.11 CDI77437.1 - 0.68 10.5 8.4 2.5 8.7 7.0 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4559 PF15112.6 CDI77437.1 - 0.79 9.3 9.6 1.2 8.7 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) ATPase PF06745.13 CDI77437.1 - 0.93 8.8 4.2 1.6 8.0 4.2 1.3 1 0 0 1 1 1 0 KaiC DHR10 PF18595.1 CDI77437.1 - 1.1 9.3 15.5 2.4 8.2 14.9 1.7 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain TBK1_CCD1 PF18394.1 CDI77437.1 - 1.4 8.4 10.6 0.2 11.2 1.7 2.1 1 1 1 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 Seryl_tRNA_N PF02403.22 CDI77437.1 - 1.7 8.9 14.4 1.5 9.1 9.3 2.4 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF2730 PF10805.8 CDI77437.1 - 1.8 8.7 6.2 1.9 8.6 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF4201 PF13870.6 CDI77437.1 - 1.9 8.2 13.2 7.5 6.3 13.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF3584 PF12128.8 CDI77437.1 - 2 5.8 14.4 3 5.2 14.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) 60KD_IMP PF02096.20 CDI77437.1 - 2.5 8.0 6.0 0.58 10.0 2.1 1.8 2 0 0 2 2 2 0 60Kd inner membrane protein Fez1 PF06818.15 CDI77437.1 - 3.2 8.1 14.8 0.74 10.2 8.9 2.1 2 0 0 2 2 2 0 Fez1 BAF1_ABF1 PF04684.13 CDI77437.1 - 3.3 6.6 19.0 3.7 6.5 2.6 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor DUF724 PF05266.14 CDI77437.1 - 3.4 7.5 12.3 6.8 6.5 12.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Nup88 PF10168.9 CDI77437.1 - 3.9 5.2 12.6 5.6 4.6 12.6 1.1 1 0 0 1 1 1 0 Nuclear pore component Hormone_1 PF00103.20 CDI77437.1 - 4.2 7.0 8.3 0.7 9.6 0.9 2.3 1 1 1 2 2 2 0 Somatotropin hormone family LMBR1 PF04791.16 CDI77437.1 - 4.4 6.1 7.3 6.3 5.6 7.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein NPV_P10 PF05531.12 CDI77437.1 - 5.1 7.6 12.8 1.4e+02 3.0 12.8 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.11 CDI77437.1 - 6 7.0 11.5 5.6 7.1 3.3 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Occludin_ELL PF07303.13 CDI77437.1 - 6.8 7.5 8.7 5.6 7.8 2.6 2.2 1 1 1 2 2 2 0 Occludin homology domain ZapB PF06005.12 CDI77437.1 - 6.9 7.2 13.0 12 6.4 0.9 2.7 1 1 1 2 2 2 0 Cell division protein ZapB CLZ PF16526.5 CDI77437.1 - 7.8 6.9 11.9 2.6 8.5 0.3 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HAUS6_N PF14661.6 CDI77437.1 - 8.9 5.8 12.0 34 3.9 12.0 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus cNMP_binding PF00027.29 CDI77438.1 - 2e-10 40.6 3.0 1.5e-06 28.1 0.1 3.8 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain DUF2339 PF10101.9 CDI77438.1 - 0.00012 20.9 9.5 0.00012 20.9 9.5 2.8 2 1 0 2 2 2 1 Predicted membrane protein (DUF2339) Pex14_N PF04695.13 CDI77438.1 - 0.0021 18.7 20.3 0.0021 18.7 20.3 15.0 4 3 5 9 9 9 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RskA PF10099.9 CDI77438.1 - 0.16 12.2 0.0 0.024 14.9 13.6 18.0 1 1 14 16 16 16 0 Anti-sigma-K factor rskA Hen1_Lam_C PF18441.1 CDI77440.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Hen1 La-motif C-terminal domain DUF4667 PF15700.5 CDI77442.1 - 0.0058 16.8 2.6 0.0079 16.3 2.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) AAA_16 PF13191.6 CDI77442.1 - 0.011 16.1 0.1 0.011 16.1 0.1 2.5 2 0 0 2 2 2 0 AAA ATPase domain SR-25 PF10500.9 CDI77442.1 - 0.02 14.5 12.0 0.02 14.5 12.0 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AAA_22 PF13401.6 CDI77442.1 - 0.02 15.1 0.1 0.19 12.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDI77442.1 - 0.029 14.6 0.0 0.029 14.6 0.0 2.9 2 1 0 2 2 1 0 AAA domain Roc PF08477.13 CDI77442.1 - 0.073 13.3 0.0 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ERM PF00769.19 CDI77442.1 - 0.078 12.8 11.2 0.13 12.0 11.2 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SRPRB PF09439.10 CDI77442.1 - 0.079 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DLIC PF05783.11 CDI77442.1 - 0.085 11.7 0.0 0.085 11.7 0.0 3.6 2 1 2 4 4 3 0 Dynein light intermediate chain (DLIC) SPX PF03105.19 CDI77442.1 - 0.092 12.7 3.9 0.13 12.2 3.9 1.2 1 0 0 1 1 1 0 SPX domain AAA_18 PF13238.6 CDI77442.1 - 0.13 12.8 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain YjbH PF06082.11 CDI77442.1 - 0.69 8.7 2.6 0.94 8.2 2.6 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Metallophos PF00149.28 CDI77443.1 - 3e-05 24.6 0.0 0.00085 19.9 0.0 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDI77443.1 - 0.0014 18.8 0.1 3.9 7.6 0.0 3.0 3 0 0 3 3 3 2 Calcineurin-like phosphoesterase superfamily domain PUB PF09409.10 CDI77444.1 - 3.2e-26 91.1 0.0 8.2e-26 89.8 0.0 1.7 1 0 0 1 1 1 1 PUB domain UBA PF00627.31 CDI77444.1 - 0.024 14.6 0.1 0.069 13.1 0.1 1.8 1 0 0 1 1 1 0 UBA/TS-N domain Big_3_3 PF13750.6 CDI77444.1 - 0.029 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) DUF2624 PF11116.8 CDI77444.1 - 0.051 14.5 2.2 0.098 13.6 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2624) MCM3AP_GANP PF16769.5 CDI77444.1 - 0.12 10.7 11.9 0.2 9.8 11.9 1.3 1 0 0 1 1 1 0 MCM3AP domain of GANP DUF2785 PF10978.8 CDI77444.1 - 2.3 8.0 8.5 13 5.5 5.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2785) V_ATPase_I PF01496.19 CDI77444.1 - 3.4 5.5 9.0 4.5 5.1 9.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 CDI77444.1 - 4 6.9 15.9 2.4 7.6 14.5 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF5401 PF17380.2 CDI77444.1 - 4.9 5.1 27.0 7.2 4.5 27.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) APG6 PF04111.12 CDI77447.1 - 8.4e-26 91.0 0.0 2.4e-22 79.8 0.0 2.7 1 1 1 2 2 2 2 Apg6 BARA domain APG6_N PF17675.1 CDI77447.1 - 1.2e-09 38.8 5.1 1.2e-09 38.8 5.1 2.1 2 0 0 2 2 2 1 Apg6 coiled-coil region AAA_13 PF13166.6 CDI77447.1 - 0.6 8.7 2.1 0.81 8.2 2.1 1.1 1 0 0 1 1 1 0 AAA domain Ctr PF04145.15 CDI77448.1 - 3.5e-09 37.4 0.0 3.5e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Ribosomal_S15 PF00312.22 CDI77450.1 - 2.7e-22 78.8 2.3 5.2e-22 77.9 2.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 Ank_2 PF12796.7 CDI77451.1 - 3.8e-44 149.2 4.4 7.2e-15 55.3 0.0 4.6 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI77451.1 - 3.6e-31 106.8 8.8 3.7e-11 43.0 0.3 6.5 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 CDI77451.1 - 2.9e-28 97.0 8.9 0.0023 18.3 0.0 7.6 7 0 0 7 7 7 7 Ankyrin repeat Ank_3 PF13606.6 CDI77451.1 - 3e-27 91.6 5.0 0.0029 18.0 0.0 8.7 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 CDI77451.1 - 3.7e-27 94.3 3.8 4.7e-09 36.6 0.5 6.9 4 2 3 7 7 7 5 Ankyrin repeats (many copies) TPR_2 PF07719.17 CDI77451.1 - 0.0025 17.8 5.8 0.54 10.5 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat UQ_con PF00179.26 CDI77452.1 - 5.2e-52 175.2 0.0 6.4e-52 174.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI77452.1 - 0.00094 18.9 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDI77452.1 - 0.028 14.7 0.0 0.044 14.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain SUIM_assoc PF16619.5 CDI77453.1 - 3e-06 27.2 17.9 0.074 13.1 0.0 6.7 5 1 1 6 6 4 1 Unstructured region C-term to UIM in Ataxin3 DUF5102 PF17104.5 CDI77453.1 - 0.021 14.9 5.4 0.067 13.2 5.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) DUF2722 PF10846.8 CDI77453.1 - 0.076 12.0 18.2 0.023 13.7 9.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF913 PF06025.12 CDI77453.1 - 0.62 9.0 2.1 1.9 7.4 0.5 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Pex14_N PF04695.13 CDI77453.1 - 1.2 9.7 20.5 0.26 11.9 7.9 4.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FHIPEP PF00771.20 CDI77453.1 - 1.6 7.1 5.2 4.2 5.7 0.1 2.2 2 0 0 2 2 2 0 FHIPEP family SpoIIP PF07454.11 CDI77453.1 - 2.7 7.4 8.0 2.8 7.3 5.3 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF719 PF05334.13 CDI77453.1 - 5.5 7.2 7.4 8.5 6.5 2.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF719) FAM176 PF14851.6 CDI77453.1 - 7 6.3 6.3 26 4.5 3.5 2.7 2 0 0 2 2 2 0 FAM176 family Neur_chan_memb PF02932.16 CDI77453.1 - 7.1 6.6 6.2 5.6 7.0 1.4 2.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Suf PF05843.14 CDI77453.1 - 7.6 6.4 15.9 4.6 7.1 8.1 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI77453.1 - 8 5.3 8.7 2.8 6.8 3.9 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Tub PF01167.18 CDI77454.1 - 2.3e-10 40.6 4.6 1.3e-07 31.6 4.6 3.2 1 1 0 1 1 1 1 Tub family eIF_4EBP PF05456.11 CDI77454.1 - 0.058 13.3 2.1 0.23 11.4 0.4 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) SAM35 PF10806.8 CDI77454.1 - 0.62 10.3 5.5 0.58 10.4 3.1 2.1 2 0 0 2 2 2 0 SAM35, subunit of SAM coomplex DUF4834 PF16118.5 CDI77454.1 - 1.1 10.3 6.9 0.62 11.1 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 CDI77454.1 - 2.5 8.1 8.0 0.16 12.0 1.3 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RNA_pol_Rbc25 PF08292.12 CDI77454.1 - 3.9 7.7 6.1 0.86 9.8 1.0 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 RskA PF10099.9 CDI77455.1 - 0.00015 22.1 3.9 0.00015 22.1 3.9 2.2 1 1 1 2 2 1 1 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI77455.1 - 0.0041 17.8 31.3 0.17 12.5 1.8 2.1 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Amnionless PF14828.6 CDI77455.1 - 0.017 14.0 8.7 0.019 13.8 8.7 1.1 1 0 0 1 1 1 0 Amnionless SID-1_RNA_chan PF13965.6 CDI77455.1 - 0.018 13.5 4.9 0.023 13.1 4.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PPP4R2 PF09184.11 CDI77455.1 - 0.021 14.4 5.3 0.028 14.0 5.3 1.1 1 0 0 1 1 1 0 PPP4R2 RPOL_N PF14700.6 CDI77455.1 - 0.034 13.6 20.4 0.24 10.7 6.3 2.1 1 1 1 2 2 2 0 DNA-directed RNA polymerase N-terminal FA_hydroxylase PF04116.13 CDI77455.1 - 0.052 13.9 0.2 0.085 13.2 0.2 1.3 1 0 0 1 1 1 0 Fatty acid hydroxylase superfamily SPX PF03105.19 CDI77455.1 - 0.06 13.3 14.6 0.076 12.9 14.6 1.1 1 0 0 1 1 1 0 SPX domain RR_TM4-6 PF06459.12 CDI77455.1 - 0.12 12.2 18.7 0.54 10.0 8.2 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RAP1 PF07218.11 CDI77455.1 - 0.21 9.8 5.8 0.25 9.6 5.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Spt20 PF12090.8 CDI77455.1 - 0.41 10.2 42.4 0.98 9.0 18.5 2.2 2 0 0 2 2 2 0 Spt20 family CaM_binding PF07839.11 CDI77455.1 - 0.53 11.0 14.8 0.12 13.1 6.5 2.2 2 0 0 2 2 2 0 Plant calmodulin-binding domain DUF4820 PF16091.5 CDI77455.1 - 0.68 9.3 18.5 1.1 8.6 6.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF4064 PF13273.6 CDI77455.1 - 1.1 9.6 3.3 2.5 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF3381 PF11861.8 CDI77455.1 - 1.1 9.0 21.7 1.1 9.0 11.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Sod_Fe_N PF00081.22 CDI77455.1 - 1.2 9.7 9.6 0.14 12.7 4.2 2.1 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, alpha-hairpin domain VKG_Carbox PF05090.14 CDI77455.1 - 1.2 7.9 7.4 1.6 7.4 7.4 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase SART-1 PF03343.13 CDI77455.1 - 1.9 6.9 21.3 2.4 6.6 21.3 1.1 1 0 0 1 1 1 0 SART-1 family EMC3_TMCO1 PF01956.16 CDI77455.1 - 2.6 7.8 10.4 0.51 10.0 2.7 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF4366 PF14283.6 CDI77455.1 - 3.7 7.6 15.4 21 5.2 10.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Band_3_cyto PF07565.13 CDI77455.1 - 3.8 7.2 15.7 4.3 7.1 2.9 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF2207 PF09972.9 CDI77455.1 - 4.3 6.0 6.2 0.5 9.1 0.6 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4746 PF15928.5 CDI77455.1 - 6.8 6.0 15.3 3.4 7.0 4.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) POPLD PF08170.12 CDI77455.1 - 7.6 6.9 7.9 5.9 7.3 2.7 2.3 2 0 0 2 2 2 0 POPLD (NUC188) domain DUF4834 PF16118.5 CDI77455.1 - 7.7 7.6 27.5 0.072 14.1 5.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) MPM1 PF17234.2 CDI77455.1 - 8 6.7 19.8 11 6.3 4.5 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4199 PF13858.6 CDI77455.1 - 8.1 6.8 8.7 10 6.5 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF5597 PF18120.1 CDI77458.1 - 0.15 12.2 2.8 0.5 10.5 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5597) Hydrolase_4 PF12146.8 CDI77459.1 - 7.2e-05 22.2 6.9 0.13 11.5 0.0 4.2 3 2 2 5 5 5 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI77459.1 - 0.0013 18.5 0.1 0.081 12.5 0.0 2.6 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDI77459.1 - 0.045 13.2 0.0 0.15 11.5 0.0 2.0 1 1 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 CDI77459.1 - 0.09 12.6 0.2 1.6 8.5 0.0 2.3 1 1 0 2 2 2 0 Phospholipase/Carboxylesterase Asp2 PF16929.5 CDI77459.1 - 0.28 10.1 0.9 0.37 9.7 0.0 1.5 2 0 0 2 2 2 0 Accessory Sec system GspB-transporter TFIIA PF03153.13 CDI77459.1 - 5.3 6.9 63.7 0.11 12.5 10.9 3.3 2 1 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit TFIIA PF03153.13 CDI77460.1 - 0.13 12.3 12.9 0.16 11.9 12.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CAML PF14963.6 CDI77460.1 - 0.55 10.3 6.3 0.053 13.6 1.0 1.8 1 1 1 2 2 2 0 Calcium signal-modulating cyclophilin ligand PAT1 PF09770.9 CDI77460.1 - 2 6.6 11.2 2.4 6.3 11.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WDCP PF15390.6 CDI77460.1 - 2.9 6.2 5.3 3.9 5.7 5.3 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Presenilin PF01080.17 CDI77460.1 - 7.6 5.2 5.3 10 4.8 5.3 1.3 1 0 0 1 1 1 0 Presenilin ADK PF00406.22 CDI77461.1 - 4.5e-32 111.2 0.0 5.3e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 CDI77461.1 - 2.4e-18 65.8 0.2 4.4e-17 61.7 0.1 2.5 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.6 CDI77461.1 - 5e-13 49.7 0.1 3.5e-12 46.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain Hydin_ADK PF17213.3 CDI77461.1 - 0.0001 22.6 0.0 0.00022 21.6 0.0 1.5 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 CDI77461.1 - 0.041 14.1 0.0 0.12 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain Sec1 PF00995.23 CDI77461.1 - 0.059 12.6 0.0 0.068 12.4 0.0 1.1 1 0 0 1 1 1 0 Sec1 family PAP2 PF01569.21 CDI77462.1 - 0.00025 20.8 0.6 0.0016 18.2 0.0 2.2 2 0 0 2 2 2 1 PAP2 superfamily Saf_2TM PF18303.1 CDI77462.1 - 0.034 13.7 0.4 0.083 12.5 0.4 1.6 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain UPF0114 PF03350.16 CDI77462.1 - 0.52 10.5 3.4 0.17 12.1 0.2 1.9 2 1 0 2 2 2 0 Uncharacterized protein family, UPF0114 PAP2 PF01569.21 CDI77463.1 - 1.4e-21 76.6 1.1 1.4e-21 76.6 1.1 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CDI77463.1 - 0.14 12.7 0.4 0.14 12.7 0.4 3.6 4 0 0 4 4 4 0 PAP2 superfamily C-terminal PDZ_6 PF17820.1 CDI77465.1 - 4.4e-05 23.3 0.1 0.00024 20.9 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDI77465.1 - 7.4e-05 23.0 0.0 0.00016 22.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDI77465.1 - 0.031 14.6 0.0 0.093 13.1 0.0 1.8 1 0 0 1 1 1 0 PDZ domain GLYCAM-1 PF05242.11 CDI77466.1 - 0.053 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) ALMT PF11744.8 CDI77466.1 - 0.11 11.3 1.0 0.14 10.9 1.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NYD-SP28_assoc PF14775.6 CDI77466.1 - 0.17 12.0 0.3 0.42 10.7 0.3 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain Cdh1_DBD_1 PF18196.1 CDI77467.1 - 3e-05 24.3 1.1 3e-05 24.3 1.1 2.4 3 0 0 3 3 3 1 Chromodomain helicase DNA-binding domain 1 DUF5327 PF17261.2 CDI77467.1 - 0.19 12.5 9.1 0.81 10.5 0.3 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5327) CDH1_2_SANT_HL1 PF18375.1 CDI77467.1 - 0.85 10.3 5.5 0.23 12.2 1.0 2.3 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Spt20 PF12090.8 CDI77467.1 - 1.9 8.0 13.5 0.61 9.7 7.7 2.4 2 0 0 2 2 2 0 Spt20 family NBD_C PF17042.5 CDI77468.1 - 0.26 11.8 5.0 0.38 11.3 5.0 1.2 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain RskA PF10099.9 CDI77468.1 - 5.5 7.2 16.8 7.3 6.8 16.8 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI77469.1 - 0.11 13.0 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Transformer PF06495.11 CDI77473.1 - 0.18 11.9 9.8 0.27 11.3 9.8 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein SOBP PF15279.6 CDI77473.1 - 5.4 7.5 11.2 7.2 7.1 11.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein HAD PF12710.7 CDI77474.1 - 0.00039 20.9 4.0 0.088 13.2 0.1 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Pex14_N PF04695.13 CDI77474.1 - 0.00093 19.9 12.6 0.00093 19.9 12.6 4.9 4 1 0 4 4 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Hydrolase_3 PF08282.12 CDI77474.1 - 0.038 13.7 8.9 0.52 10.0 7.9 2.7 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDI77474.1 - 0.07 13.4 15.3 0.016 15.5 7.3 3.1 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase SPT16 PF08644.11 CDI77474.1 - 1.2 9.3 6.7 2.5 8.3 6.7 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) MCU PF04678.13 CDI77474.1 - 1.4 9.0 8.1 3.4 7.8 8.1 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Peptidase_S49_N PF08496.10 CDI77474.1 - 1.6 8.8 8.5 2.9 7.9 8.5 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Tim54 PF11711.8 CDI77474.1 - 1.7 7.3 13.0 0.058 12.2 6.2 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 TFB6 PF17110.5 CDI77474.1 - 1.9 8.2 5.5 4.5 7.0 5.5 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PepSY_TM PF03929.16 CDI77474.1 - 2.9 7.5 8.2 3.2 7.3 3.6 2.5 2 0 0 2 2 2 0 PepSY-associated TM region PAT1 PF09770.9 CDI77474.1 - 3.7 5.7 20.7 6.1 5.0 20.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MRP-S27 PF10037.9 CDI77474.1 - 3.8 6.3 15.2 5.2 5.8 15.2 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 GNAT_acetyltr_2 PF13718.6 CDI77474.1 - 5.5 6.3 9.8 13 5.1 9.8 1.6 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Connexin PF00029.19 CDI77474.1 - 5.6 6.7 10.8 21 4.8 9.2 2.3 2 0 0 2 2 2 0 Connexin DUF3292 PF11696.8 CDI77474.1 - 7.1 4.9 11.8 12 4.1 11.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DDRGK PF09756.9 CDI77474.1 - 8.9 5.9 19.8 15 5.1 19.8 1.2 1 0 0 1 1 1 0 DDRGK domain TFIIA PF03153.13 CDI77475.1 - 0.00058 20.0 34.7 0.00058 20.0 34.7 8.9 4 3 2 7 7 7 1 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI77476.1 - 0.22 10.3 7.1 4.9 5.9 7.1 2.0 1 1 0 1 1 1 0 Golgi-body localisation protein domain Exonuc_VII_L PF02601.15 CDI77477.1 - 2.8 7.4 27.7 1.3 8.5 2.2 3.3 2 1 1 3 3 3 0 Exonuclease VII, large subunit RAP1 PF07218.11 CDI77477.1 - 4.7 5.4 13.2 9.1 4.4 13.2 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ArfGap PF01412.18 CDI77478.1 - 2.3e-11 43.8 4.8 3.6e-08 33.5 0.0 3.5 2 1 1 3 3 3 2 Putative GTPase activating protein for Arf TFIIA PF03153.13 CDI77478.1 - 0.0028 17.7 28.2 0.0042 17.1 28.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI77478.1 - 0.34 9.4 16.1 0.46 9.0 16.1 1.1 1 0 0 1 1 1 0 Macoilin family DUF1387 PF07139.11 CDI77478.1 - 3.1 7.5 14.0 4.5 6.9 14.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SLC12 PF03522.15 CDI77478.1 - 5.6 5.9 8.0 7.3 5.5 8.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 V_ATPase_I PF01496.19 CDI77478.1 - 5.7 4.7 6.1 7.4 4.4 6.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family E1-E2_ATPase PF00122.20 CDI77479.1 - 4.5e-22 78.5 0.2 4.5e-22 78.5 0.2 3.3 4 0 0 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 CDI77479.1 - 4.9e-18 66.2 0.0 3.8e-12 46.9 0.0 4.7 4 1 0 4 4 4 2 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDI77479.1 - 2.5e-10 40.7 0.0 5.6e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CDI77479.1 - 0.013 15.2 0.0 3.4 7.3 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Zea_mays_MuDR PF05928.11 CDI77479.1 - 1.9 8.1 3.3 2.6 7.7 2.0 1.8 2 0 0 2 2 2 0 Zea mays MURB-like protein (MuDR) Virul_fac_BrkB PF03631.15 CDI77480.1 - 0.0036 17.0 1.5 0.0036 17.0 1.5 3.3 4 0 0 4 4 4 1 Virulence factor BrkB SUR7 PF06687.12 CDI77480.1 - 0.011 15.4 0.9 0.011 15.4 0.9 2.9 3 0 0 3 3 3 0 SUR7/PalI family Wzy_C PF04932.15 CDI77480.1 - 0.06 13.0 3.4 0.27 10.9 0.1 2.6 3 0 0 3 3 3 0 O-Antigen ligase Orthopox_B11R PF07033.11 CDI77480.1 - 0.16 11.8 0.3 0.43 10.4 0.3 1.7 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Plasmod_dom_1 PF09715.10 CDI77480.1 - 0.41 10.8 1.9 1.3 9.1 0.1 2.7 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) PalH PF08733.10 CDI77480.1 - 3.4 6.6 5.4 20 4.1 0.0 2.6 3 0 0 3 3 3 0 PalH/RIM21 DUF2207 PF09972.9 CDI77480.1 - 5.1 5.8 11.1 0.3 9.8 0.1 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DEAD PF00270.29 CDI77481.1 - 1.7e-25 89.8 0.0 2.5e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI77481.1 - 1.7e-12 47.6 0.0 3.8e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDI77481.1 - 0.0089 16.3 0.0 0.059 13.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain Abhydrolase_6 PF12697.7 CDI77482.1 - 1.3e-18 68.4 0.1 2.2e-18 67.7 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDI77482.1 - 1.2e-07 31.3 0.3 3.2e-06 26.6 0.3 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI77482.1 - 1.8e-05 24.5 0.0 3.8e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CDI77482.1 - 0.00038 20.2 0.0 0.00053 19.8 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.20 CDI77482.1 - 0.027 14.6 0.0 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 Thioesterase domain Abhydrolase_5 PF12695.7 CDI77482.1 - 0.033 14.0 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 CDI77482.1 - 0.039 13.8 0.1 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 3) Dynein_C PF18199.1 CDI77483.1 - 1.5e-57 195.1 0.0 2.4e-56 191.2 0.0 2.2 1 1 1 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 CDI77483.1 - 6.1e-55 185.7 6.3 9e-55 185.2 5.6 1.6 2 0 0 2 2 2 1 ATP-binding dynein motor region Dynein_heavy PF03028.15 CDI77483.1 - 2e-21 76.3 0.0 1.2e-18 67.4 0.0 2.9 2 0 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 CDI77483.1 - 1.7e-17 63.7 0.0 5e-17 62.2 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain MT PF12777.7 CDI77484.1 - 1.5e-74 251.1 13.6 2e-74 250.7 13.6 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.7 CDI77484.1 - 2e-65 220.7 0.0 5.1e-57 193.2 0.0 2.6 1 1 1 2 2 2 2 P-loop containing dynein motor region D4 AAA_7 PF12775.7 CDI77484.1 - 3.9e-35 121.0 1.0 2.2e-29 102.3 0.2 2.4 1 1 1 2 2 2 2 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 CDI77484.1 - 6e-20 71.6 2.5 2.3e-19 69.7 2.5 2.1 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 CDI77484.1 - 3.1e-07 30.5 0.0 7.2e-05 22.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 CDI77484.1 - 0.00012 22.3 0.0 0.00041 20.5 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain DUF1327 PF07041.11 CDI77484.1 - 0.063 13.3 0.0 0.28 11.2 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1327) UPF0242 PF06785.11 CDI77484.1 - 0.07 13.2 14.4 0.32 11.1 6.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TPK_catalytic PF04263.16 CDI77484.1 - 0.16 12.0 0.1 9.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain Spc7 PF08317.11 CDI77484.1 - 0.4 9.5 22.6 0.018 13.9 1.2 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2347 PF09804.9 CDI77484.1 - 0.49 9.9 2.3 0.49 9.9 0.3 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) Sec34 PF04136.15 CDI77484.1 - 0.57 10.1 7.4 5.4 6.9 0.4 3.0 2 1 0 2 2 2 0 Sec34-like family DUF3450 PF11932.8 CDI77484.1 - 0.59 9.4 20.0 0.41 9.9 3.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Orbi_VP5 PF00901.17 CDI77484.1 - 0.97 7.7 5.5 0.17 10.2 0.6 1.9 2 0 0 2 2 2 0 Orbivirus outer capsid protein VP5 DUF1664 PF07889.12 CDI77484.1 - 1.6 8.8 12.8 5.5 7.0 0.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 CDI77484.1 - 2.1 8.4 19.6 0.019 15.0 1.8 3.3 2 1 1 3 3 3 0 Laminin Domain II DUF948 PF06103.11 CDI77484.1 - 4.1 7.7 9.7 2.2 8.6 0.3 3.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) CENP-H PF05837.12 CDI77484.1 - 7.4 7.0 18.4 7.2 7.1 2.4 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) AAA_6 PF12774.7 CDI77485.1 - 2.6e-135 450.6 0.1 1.8e-94 316.4 0.0 2.1 2 0 0 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_5 PF07728.14 CDI77485.1 - 5.2e-10 39.4 0.0 9.7e-07 28.9 0.0 3.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI77485.1 - 1.1e-05 26.0 0.1 0.36 11.4 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 CDI77485.1 - 0.00012 22.5 0.3 0.082 13.3 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI77485.1 - 0.0013 19.2 0.1 2.4 8.5 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_7 PF12775.7 CDI77485.1 - 0.0015 18.1 0.1 0.23 11.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 CDI77485.1 - 0.0017 18.6 0.0 2.3 8.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CDI77485.1 - 0.0041 17.3 0.2 2.4 8.3 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CDI77485.1 - 0.0047 16.7 0.3 1.4 8.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDI77485.1 - 0.0069 16.8 0.0 1.6 9.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Cytidylate_kin PF02224.18 CDI77485.1 - 0.032 13.9 0.5 4.2 7.1 0.0 2.8 3 0 0 3 3 3 0 Cytidylate kinase ATP_bind_1 PF03029.17 CDI77485.1 - 0.054 13.3 1.4 1.5 8.5 0.1 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 CDI77485.1 - 0.069 12.4 0.1 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin KTI12 PF08433.10 CDI77485.1 - 0.089 12.2 0.0 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 MeaB PF03308.16 CDI77485.1 - 0.14 11.1 0.0 0.3 10.0 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 CDI77485.1 - 0.22 11.8 0.3 10 6.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain DHC_N2 PF08393.13 CDI77486.1 - 2.1e-10 40.3 8.5 1.3e-09 37.7 1.4 2.9 1 1 2 3 3 3 2 Dynein heavy chain, N-terminal region 2 TIG PF01833.24 CDI77486.1 - 2.8e-06 27.3 0.6 5.2e-06 26.5 0.6 1.5 1 0 0 1 1 1 1 IPT/TIG domain Filamin PF00630.19 CDI77486.1 - 0.00075 20.3 0.0 0.0016 19.3 0.0 1.6 1 1 0 1 1 1 1 Filamin/ABP280 repeat FANCI_S3 PF14677.6 CDI77486.1 - 0.012 15.3 0.1 0.036 13.8 0.1 1.7 1 0 0 1 1 1 0 FANCI solenoid 3 NPV_P10 PF05531.12 CDI77486.1 - 0.021 15.3 8.6 10 6.7 0.7 4.5 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein Neuropep_like PF15161.6 CDI77486.1 - 0.066 12.9 0.2 0.42 10.3 0.1 2.5 2 1 0 2 2 2 0 Neuropeptide-like Syntaxin_2 PF14523.6 CDI77486.1 - 0.13 12.6 3.2 1.2 9.5 0.0 3.3 2 1 1 3 3 3 0 Syntaxin-like protein Cep57_CLD_2 PF14197.6 CDI77486.1 - 0.51 10.5 7.5 0.29 11.2 4.0 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF4094 PF13334.6 CDI77486.1 - 0.93 10.0 5.9 0.27 11.7 0.3 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF2203 PF09969.9 CDI77486.1 - 9.3 7.0 7.6 7.1 7.4 0.4 3.3 1 1 3 4 4 4 0 Uncharacterized conserved protein (DUF2203) Med21 PF11221.8 CDI77490.1 - 4.6e-11 43.2 0.1 5.8e-11 42.8 0.1 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex AIRS_C PF02769.22 CDI77490.1 - 0.024 14.7 0.3 0.29 11.2 0.0 2.0 1 1 1 2 2 2 0 AIR synthase related protein, C-terminal domain UPF0184 PF03670.13 CDI77490.1 - 0.031 14.6 0.2 0.043 14.2 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) GCN5L1 PF06320.13 CDI77490.1 - 0.034 14.3 0.9 0.048 13.8 0.9 1.1 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) APG6_N PF17675.1 CDI77490.1 - 0.055 14.0 2.0 0.07 13.7 2.0 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region MCPsignal PF00015.21 CDI77490.1 - 0.055 13.3 4.1 0.075 12.9 4.1 1.1 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CREPT PF16566.5 CDI77490.1 - 0.06 13.5 0.3 0.085 13.0 0.3 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Clavanin PF05452.11 CDI77490.1 - 0.21 11.8 0.0 6.1 7.1 0.0 2.2 2 0 0 2 2 2 0 Clavanin DUF3606 PF12244.8 CDI77490.1 - 0.28 11.1 3.2 0.34 10.9 2.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) MMR_HSR1 PF01926.23 CDI77491.1 - 1.6e-12 47.5 0.0 5.9e-12 45.7 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI77491.1 - 0.00051 19.6 0.0 0.00088 18.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CDI77491.1 - 0.0026 17.1 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 AIG1 family Pkinase PF00069.25 CDI77493.1 - 7.7e-48 163.1 0.0 1.1e-47 162.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77493.1 - 4.9e-42 144.0 0.0 6.7e-42 143.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI77493.1 - 0.013 14.3 1.3 2.8 6.6 0.8 2.3 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 CDI77493.1 - 0.018 14.0 0.3 0.031 13.2 0.3 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 CDI77493.1 - 0.027 14.1 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CDI77493.1 - 0.05 13.5 0.0 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Actin PF00022.19 CDI77494.1 - 5.3e-144 479.8 0.0 2.3e-143 477.7 0.0 1.7 1 1 0 1 1 1 1 Actin AP2 PF00847.20 CDI77495.1 - 9.2e-18 64.2 7.2 1.6e-07 31.5 0.4 3.7 3 0 0 3 3 3 3 AP2 domain AP2 PF00847.20 CDI77496.1 - 7.5e-08 32.5 3.1 0.0065 16.7 0.8 2.4 2 0 0 2 2 2 2 AP2 domain LRR_6 PF13516.6 CDI77497.1 - 9.6e-09 34.6 0.5 1.2 9.4 0.0 4.6 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 CDI77497.1 - 0.0079 16.6 0.5 0.54 10.8 0.2 2.9 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDI77497.1 - 0.17 12.6 0.2 52 5.0 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat ABC_tran PF00005.27 CDI77498.1 - 7.7e-32 110.7 0.1 2.2e-30 106.0 0.1 2.4 1 1 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDI77498.1 - 7e-14 52.1 0.7 5.4e-12 45.9 0.5 2.3 1 1 1 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 CDI77498.1 - 3.5e-09 36.4 0.0 2e-07 30.7 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDI77498.1 - 8.6e-06 26.1 0.1 0.016 15.5 0.1 2.8 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDI77498.1 - 0.0011 19.4 9.5 0.012 16.0 9.2 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDI77498.1 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 CDI77498.1 - 0.0071 16.8 0.1 4.4 7.7 0.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDI77498.1 - 0.0073 15.9 0.3 1.4 8.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDI77498.1 - 0.01 15.6 4.8 1.6 8.4 4.8 2.8 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 CDI77498.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Zeta_toxin PF06414.12 CDI77498.1 - 0.028 13.7 0.0 0.028 13.7 0.0 2.4 3 0 0 3 3 3 0 Zeta toxin Rad17 PF03215.15 CDI77498.1 - 0.039 13.9 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_14 PF13173.6 CDI77498.1 - 0.072 13.1 0.0 1 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDI77498.1 - 0.1 12.5 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 1 0 RsgA GTPase IstB_IS21 PF01695.17 CDI77498.1 - 0.1 12.3 0.0 10 5.8 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_21 PF13304.6 CDI77498.1 - 0.11 12.3 0.0 2.7 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 CDI77498.1 - 0.11 12.5 0.0 0.37 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2722 PF10846.8 CDI77498.1 - 0.11 11.4 13.5 0.19 10.6 13.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) AAA_24 PF13479.6 CDI77498.1 - 0.14 11.8 0.2 0.59 9.8 0.0 2.0 2 1 1 3 3 2 0 AAA domain AAA_23 PF13476.6 CDI77498.1 - 0.21 12.0 7.0 3.1 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fmp27_SW PF10305.9 CDI77498.1 - 0.22 12.3 4.1 0.47 11.2 4.1 1.4 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF702 PF05142.12 CDI77498.1 - 0.51 10.8 5.5 1.3 9.5 5.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Cytidylate_kin PF02224.18 CDI77498.1 - 1.2 8.8 7.2 5.7 6.6 6.7 2.0 1 1 1 2 2 1 0 Cytidylate kinase SbcCD_C PF13558.6 CDI77498.1 - 4.5 7.6 6.0 0.54 10.5 0.4 2.4 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit TFIIA PF03153.13 CDI77498.1 - 4.9 7.0 21.2 0.21 11.5 14.6 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_33 PF13671.6 CDI77498.1 - 6.1 7.0 8.1 81 3.4 8.1 2.3 1 1 0 1 1 1 0 AAA domain RR_TM4-6 PF06459.12 CDI77499.1 - 0.025 14.4 17.6 0.031 14.1 17.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CDI77499.1 - 0.042 13.5 20.4 0.063 12.9 20.4 1.4 1 0 0 1 1 1 0 Spt20 family DUF1387 PF07139.11 CDI77499.1 - 0.53 10.0 13.1 0.69 9.6 13.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) eIF-3_zeta PF05091.12 CDI77499.1 - 0.74 8.7 14.2 0.97 8.3 14.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GNT-I PF03071.15 CDI77499.1 - 0.81 8.4 3.9 1 8.1 3.9 1.1 1 0 0 1 1 1 0 GNT-I family Hid1 PF12722.7 CDI77499.1 - 0.85 7.7 11.6 0.82 7.7 11.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Endostatin PF06482.11 CDI77499.1 - 0.91 8.9 9.2 1.2 8.6 9.2 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Plasmodium_Vir PF05795.11 CDI77499.1 - 1.4 8.3 5.9 1.7 7.9 5.9 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Mitofilin PF09731.9 CDI77499.1 - 2.1 7.1 30.2 2.5 6.8 30.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Band_3_cyto PF07565.13 CDI77499.1 - 3.2 7.5 11.1 4.7 6.9 11.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI77499.1 - 3.4 7.6 12.3 4.8 7.2 12.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 CDI77499.1 - 4.1 7.1 6.1 6.3 6.5 6.1 1.3 1 0 0 1 1 1 0 Connexin SOBP PF15279.6 CDI77499.1 - 4.3 7.9 16.2 5.5 7.5 16.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI77499.1 - 5.3 5.2 20.7 5.9 5.0 20.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 CDI77499.1 - 5.8 5.6 9.8 7.2 5.3 9.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Macoilin PF09726.9 CDI77499.1 - 6.1 5.3 12.1 6.8 5.1 12.1 1.2 1 0 0 1 1 1 0 Macoilin family DUF2981 PF11200.8 CDI77499.1 - 7.7 6.2 10.8 10 5.8 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) HATPase_c PF02518.26 CDI77501.1 - 0.00015 22.2 0.0 0.0007 20.1 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_carr PF00153.27 CDI77502.1 - 0.34 10.8 2.2 1 9.3 0.0 3.1 2 0 0 2 2 2 0 Mitochondrial carrier protein ApbA PF02558.16 CDI77503.1 - 0.00047 19.8 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Hydrolase PF00702.26 CDI77504.1 - 7.7e-17 62.3 2.5 1.3e-05 25.6 0.0 4.8 4 0 0 4 4 4 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI77504.1 - 1.9e-07 30.8 0.1 0.00097 18.7 0.0 3.2 1 1 1 2 2 2 2 E1-E2 ATPase DUF4834 PF16118.5 CDI77504.1 - 0.00039 21.3 2.4 0.00039 21.3 2.4 9.3 11 0 0 11 11 11 1 Domain of unknown function (DUF4834) ERF PF04404.12 CDI77504.1 - 0.00091 19.1 4.6 0.00091 19.1 4.6 5.3 7 0 0 7 7 7 1 ERF superfamily SPX PF03105.19 CDI77504.1 - 0.0017 18.4 0.0 0.0017 18.4 0.0 5.0 2 2 0 2 2 2 1 SPX domain NAM-associated PF14303.6 CDI77504.1 - 0.036 14.8 0.0 0.036 14.8 0.0 6.4 7 2 0 7 7 7 0 No apical meristem-associated C-terminal domain HAD PF12710.7 CDI77504.1 - 0.05 14.0 0.4 7.2 7.0 0.0 2.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Arginase PF00491.21 CDI77504.1 - 1.4 8.4 4.5 5.2 6.5 0.0 3.1 2 1 1 3 3 3 0 Arginase family RskA PF10099.9 CDI77504.1 - 2 8.7 0.0 2 8.7 0.0 9.9 6 3 3 10 10 10 0 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI77504.1 - 7.8 4.8 22.3 0.12 10.8 0.1 3.6 5 0 0 5 5 5 0 dsRNA-gated channel SID-1 EF-hand_1 PF00036.32 CDI77505.1 - 1.3e-28 96.3 9.1 4.2e-05 22.8 0.3 6.6 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 CDI77505.1 - 7.5e-26 90.4 9.3 2.2e-09 37.6 0.6 3.8 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 CDI77505.1 - 1e-24 84.9 8.9 4.4e-05 22.8 0.1 6.6 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.6 CDI77505.1 - 5e-24 82.1 4.9 0.00044 20.0 0.0 6.3 6 0 0 6 6 6 5 EF-hand domain SPARC_Ca_bdg PF10591.9 CDI77505.1 - 4.4e-11 43.1 8.0 0.018 15.4 0.2 3.6 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 CDI77505.1 - 9e-11 41.5 7.2 0.028 14.3 0.1 5.7 5 1 0 5 5 5 4 EF-hand domain pair Arg_decarbox_C PF17944.1 CDI77505.1 - 0.0017 18.9 1.4 0.76 10.4 0.1 3.5 3 0 0 3 3 3 1 Arginine decarboxylase C-terminal helical extension Dockerin_1 PF00404.18 CDI77505.1 - 0.0018 18.4 1.8 0.8 9.9 0.1 3.5 2 2 1 3 3 3 1 Dockerin type I domain Unstab_antitox PF09720.10 CDI77505.1 - 0.008 16.2 0.1 0.008 16.2 0.1 3.3 4 1 1 5 5 4 1 Putative addiction module component EF-hand_4 PF12763.7 CDI77505.1 - 0.011 15.7 7.0 0.7 9.9 0.0 4.1 2 1 2 5 5 5 0 Cytoskeletal-regulatory complex EF hand MscS_porin PF12795.7 CDI77505.1 - 0.035 13.6 0.3 0.071 12.6 0.3 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain O-FucT PF10250.9 CDI77505.1 - 0.041 13.6 0.4 0.041 13.6 0.4 1.9 2 1 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase TAFH PF07531.14 CDI77505.1 - 0.056 13.6 0.5 2.4 8.3 0.1 2.5 2 0 0 2 2 2 0 NHR1 homology to TAF DUF3145 PF11343.8 CDI77505.1 - 0.07 12.7 0.9 0.21 11.1 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3145) Rx_N PF18052.1 CDI77505.1 - 0.089 13.1 1.0 0.28 11.5 0.1 2.2 2 0 0 2 2 2 0 Rx N-terminal domain DUF3349 PF11829.8 CDI77505.1 - 0.65 10.8 4.1 9.2 7.1 0.2 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF3349) Iron_permease PF04120.12 CDI77505.1 - 0.85 9.4 5.4 2.3 8.0 0.5 2.5 2 1 0 2 2 2 0 Low affinity iron permease YtkA PF13115.6 CDI77505.1 - 2.3 8.9 6.2 1.1 9.9 0.4 2.9 2 1 2 4 4 4 0 YtkA-like Cas_csx3 PF09620.10 CDI77506.1 - 0.054 13.4 0.0 3 7.8 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_csx3) PAS_4 PF08448.10 CDI77506.1 - 0.092 13.0 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 PAS fold DUF3954 PF13128.6 CDI77506.1 - 0.13 12.0 1.0 0.2 11.5 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) Aldo_ket_red PF00248.21 CDI77507.1 - 2.1e-32 112.5 0.0 5.3e-27 94.8 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family SUIM_assoc PF16619.5 CDI77507.1 - 0.00051 20.1 2.3 0.0014 18.6 2.3 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Ank_4 PF13637.6 CDI77509.1 - 1.7e-14 54.0 1.8 5.7e-06 26.8 0.0 3.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI77509.1 - 1.7e-14 54.1 0.3 1.4e-08 35.2 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CDI77509.1 - 3e-12 46.4 0.2 7.7e-06 26.1 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 CDI77509.1 - 1.5e-11 43.4 2.4 1.2e-05 25.3 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CDI77509.1 - 5.6e-10 39.3 0.5 3.2e-05 24.1 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) RskA PF10099.9 CDI77509.1 - 0.29 11.4 6.8 0.76 10.0 6.8 1.7 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF3446 PF11928.8 CDI77509.1 - 0.56 10.5 12.3 0.064 13.6 3.4 2.9 3 0 0 3 3 3 0 Early growth response N-terminal domain Spt20 PF12090.8 CDI77509.1 - 3.6 7.1 9.4 6 6.4 9.4 1.3 1 0 0 1 1 1 0 Spt20 family IMUP PF15761.5 CDI77511.1 - 0.046 14.4 4.3 0.046 14.4 4.3 1.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein TFIIA PF03153.13 CDI77511.1 - 0.056 13.4 8.8 0.074 13.0 8.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3880 PF12996.7 CDI77511.1 - 0.1 12.7 0.5 0.33 11.1 0.1 2.0 2 0 0 2 2 2 0 DUF based on E. rectale Gene description (DUF3880) Dehydrin PF00257.19 CDI77511.1 - 0.13 12.8 1.8 2 9.0 0.1 2.3 2 0 0 2 2 2 0 Dehydrin RskA PF10099.9 CDI77512.1 - 0.00037 20.8 1.8 0.00037 20.8 1.8 7.9 1 1 3 5 5 5 1 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI77513.1 - 2.5e-05 24.5 32.2 0.00094 19.3 16.2 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 CDI77513.1 - 9.1e-05 21.5 29.1 0.00026 20.0 10.1 3.2 3 0 0 3 3 3 3 Androgen receptor SDA1 PF05285.12 CDI77513.1 - 0.0025 17.3 8.9 0.0025 17.3 8.9 1.5 2 0 0 2 2 2 1 SDA1 LAP1C PF05609.12 CDI77513.1 - 7.9 5.4 28.6 0.29 10.2 18.9 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_C2 PF00648.21 CDI77514.1 - 5.5e-29 101.1 0.0 1.7e-26 92.9 0.0 3.2 2 1 0 2 2 2 2 Calpain family cysteine protease Apt1 PF10351.9 CDI77514.1 - 0.88 8.4 31.8 0.074 11.9 14.4 3.2 3 0 0 3 3 3 0 Golgi-body localisation protein domain DDHD PF02862.17 CDI77514.1 - 2.6 8.1 24.5 0.96 9.6 1.8 3.7 3 0 0 3 3 3 0 DDHD domain SpoIIP PF07454.11 CDI77514.1 - 2.8 7.3 18.0 4.7 6.6 2.3 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RPA43_OB PF17875.1 CDI77514.1 - 7.6 7.2 10.6 13 6.4 2.8 2.8 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I NodS PF05401.11 CDI77515.1 - 0.089 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) PhyH PF05721.13 CDI77516.1 - 5.6e-07 30.0 0.0 2.3e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.16 CDI77516.1 - 0.036 13.9 0.0 0.16 11.7 0.0 2.1 1 1 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family Gram_pos_anchor PF00746.21 CDI77516.1 - 1.3 9.1 3.7 3 7.9 3.7 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DNA_pol_B PF00136.21 CDI77517.1 - 1.1e-50 172.7 0.0 1.8e-50 172.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.6 CDI77517.1 - 5.8e-07 29.9 5.3 5.8e-07 29.9 5.3 3.8 3 0 0 3 3 3 1 C4-type zinc-finger of DNA polymerase delta MRAP PF15183.6 CDI77518.1 - 0.1 12.6 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Mago-bind PF09282.10 CDI77518.1 - 0.26 11.2 2.0 19 5.2 0.4 2.4 2 0 0 2 2 2 0 Mago binding TRPM_tetra PF16519.5 CDI77519.1 - 0.14 12.3 2.1 0.21 11.7 0.1 2.3 3 0 0 3 3 3 0 Tetramerisation domain of TRPM DUF45 PF01863.17 CDI77520.1 - 0.00017 21.7 0.0 0.00017 21.7 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function DUF45 WLM PF08325.10 CDI77520.1 - 0.026 14.6 0.2 0.026 14.6 0.2 2.2 2 0 0 2 2 2 0 WLM domain Mito_carr PF00153.27 CDI77521.1 - 5.7e-54 180.0 2.2 1.4e-22 79.4 0.0 4.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Ndc1_Nup PF09531.10 CDI77521.1 - 0.086 11.5 0.4 0.13 10.9 0.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-C2H2_2 PF12756.7 CDI77523.1 - 2.6e-18 66.2 1.5 2.6e-18 66.2 1.5 2.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) eIF-3c_N PF05470.12 CDI77523.1 - 0.031 12.6 0.7 0.043 12.1 0.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Spore_coat_CotO PF14153.6 CDI77523.1 - 0.23 11.4 6.7 2.5 8.0 0.9 2.3 2 0 0 2 2 2 0 Spore coat protein CotO AMP-binding PF00501.28 CDI77524.1 - 2.2e-17 62.8 0.0 8.3e-15 54.3 0.0 3.6 2 1 0 2 2 2 2 AMP-binding enzyme PKD_channel PF08016.12 CDI77525.1 - 1.5e-16 60.1 16.3 4.5e-08 32.2 10.5 3.4 3 0 0 3 3 3 3 Polycystin cation channel Kinesin PF00225.23 CDI77526.1 - 1.9e-85 286.7 0.0 2e-43 148.6 0.1 2.4 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 CDI77526.1 - 3.4e-20 72.5 0.0 1.1e-19 70.9 0.0 1.9 1 1 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 CDI77526.1 - 6.9e-06 26.3 10.8 0.003 17.7 0.7 3.4 2 1 1 3 3 3 2 Kinesin-associated KIF1B PF12423.8 CDI77526.1 - 7.4e-06 26.3 0.1 3.8e-05 24.0 0.0 2.3 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.26 CDI77526.1 - 0.1 12.9 0.0 0.39 11.1 0.0 2.0 1 0 0 1 1 1 0 FHA domain V_ATPase_I PF01496.19 CDI77526.1 - 3.2 5.6 5.1 6.2 4.6 5.1 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Stealth_CR3 PF17102.5 CDI77526.1 - 5.2 7.0 4.9 46 4.0 0.7 3.1 2 1 1 3 3 3 0 Stealth protein CR3, conserved region 3 TSNAXIP1_N PF15739.5 CDI77527.1 - 0.03 14.7 1.0 0.094 13.1 0.0 2.3 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Macoilin PF09726.9 CDI77527.1 - 0.18 10.3 18.4 0.27 9.7 18.3 1.3 1 1 0 1 1 1 0 Macoilin family SOBP PF15279.6 CDI77527.1 - 4.5 7.8 13.7 1.4 9.5 7.7 2.0 2 0 0 2 2 2 0 Sine oculis-binding protein Shisa PF13908.6 CDI77527.1 - 9.7 6.4 10.0 2.5 8.3 5.5 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Mg_trans_NIPA PF05653.14 CDI77530.1 - 5.1e-22 78.3 7.1 7.7e-22 77.7 7.1 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CDI77530.1 - 3.2e-05 24.1 5.1 3.2e-05 24.1 5.1 3.0 2 2 0 2 2 2 1 EamA-like transporter family Spt20 PF12090.8 CDI77530.1 - 4.1 7.0 13.5 0.69 9.5 9.2 1.7 2 0 0 2 2 2 0 Spt20 family ERO1 PF04137.15 CDI77532.1 - 2.7e-28 99.2 6.8 2.7e-28 99.2 6.8 3.5 2 2 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) SNF2_N PF00176.23 CDI77532.1 - 1.2 7.7 7.9 0.026 13.3 0.7 1.8 2 0 0 2 2 2 0 SNF2 family N-terminal domain RskA PF10099.9 CDI77533.1 - 0.0012 19.1 2.5 0.0012 19.1 2.5 21.1 4 3 11 17 17 17 2 Anti-sigma-K factor rskA ArsA_ATPase PF02374.15 CDI77534.1 - 1e-53 182.5 0.5 7.9e-39 133.6 0.0 2.1 1 1 1 2 2 2 2 Anion-transporting ATPase Med25_VWA PF11265.8 CDI77534.1 - 0.033 14.0 0.0 0.071 12.9 0.0 1.5 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A CS PF04969.16 CDI77535.1 - 0.00012 23.0 0.0 0.0039 18.2 0.0 2.4 1 1 0 1 1 1 1 CS domain SR-25 PF10500.9 CDI77535.1 - 0.013 15.2 5.3 0.013 15.2 5.3 5.0 5 1 0 5 5 5 0 Nuclear RNA-splicing-associated protein CDC37_N PF03234.14 CDI77535.1 - 0.044 14.7 2.0 0.044 14.7 2.0 5.3 5 1 0 5 5 5 0 Cdc37 N terminal kinase binding TatD_DNase PF01026.21 CDI77535.1 - 0.16 11.3 8.8 1.1 8.5 3.9 3.0 2 1 0 2 2 2 0 TatD related DNase PIG-L PF02585.17 CDI77536.1 - 2.8e-20 73.3 1.0 1.2e-19 71.2 0.0 2.4 3 0 0 3 3 2 1 GlcNAc-PI de-N-acetylase Presenilin PF01080.17 CDI77536.1 - 0.0019 17.0 10.9 0.0026 16.6 1.1 2.3 2 1 0 2 2 2 1 Presenilin Adaptin_binding PF10199.9 CDI77536.1 - 0.0028 18.3 6.9 0.95 10.1 0.6 3.0 3 0 0 3 3 3 2 Alpha and gamma adaptin binding protein p34 DUF2722 PF10846.8 CDI77536.1 - 0.0097 14.9 18.1 0.022 13.7 0.9 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) Peptidase_S49_N PF08496.10 CDI77536.1 - 0.017 15.1 1.7 0.017 15.1 1.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SpoIIP PF07454.11 CDI77536.1 - 0.032 13.7 11.0 0.4 10.1 1.3 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) CCDC53 PF10152.9 CDI77536.1 - 0.068 13.6 11.5 1.9 8.9 0.4 3.1 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex AAA_23 PF13476.6 CDI77536.1 - 0.069 13.7 14.7 0.14 12.7 0.2 2.2 2 0 0 2 2 2 0 AAA domain Kei1 PF08552.11 CDI77536.1 - 0.097 12.5 0.0 0.097 12.5 0.0 3.4 4 0 0 4 4 4 0 Inositolphosphorylceramide synthase subunit Kei1 TRAP_alpha PF03896.16 CDI77536.1 - 0.11 11.7 6.8 1.1 8.5 0.9 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 CDI77536.1 - 0.15 11.8 7.9 0.72 9.6 0.7 2.3 2 0 0 2 2 2 0 Connexin CSG2 PF16965.5 CDI77536.1 - 0.19 10.6 3.8 1.7 7.5 0.1 2.4 3 0 0 3 3 3 0 Ceramide synthase regulator Saw1 PF11561.8 CDI77536.1 - 0.26 10.8 0.0 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 Single strand annealing-weakened 1 Serinc PF03348.15 CDI77536.1 - 0.37 9.6 6.0 0.78 8.6 0.4 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) Eapp_C PF10238.9 CDI77536.1 - 0.42 10.7 20.5 0.12 12.5 4.8 2.8 3 0 0 3 3 3 0 E2F-associated phosphoprotein V_ATPase_I PF01496.19 CDI77536.1 - 0.48 8.3 11.1 0.22 9.4 1.0 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Pex14_N PF04695.13 CDI77536.1 - 0.97 10.1 20.0 2.7 8.6 0.6 3.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI77536.1 - 1.6 9.1 16.7 0.3 11.5 1.1 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 CDI77536.1 - 2.7 8.0 15.0 1.9 8.5 4.0 2.7 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PIG-S PF10510.9 CDI77536.1 - 3.9 6.2 9.4 1.3 7.8 1.4 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein DUF4834 PF16118.5 CDI77536.1 - 5.5 8.0 19.1 0.26 12.3 0.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Zip PF02535.22 CDI77536.1 - 5.6 6.1 12.3 2.5 7.2 1.0 2.9 3 0 0 3 3 3 0 ZIP Zinc transporter Peroxin-13_N PF04088.13 CDI77536.1 - 7.1 6.9 8.3 7.5 6.8 0.5 2.7 3 0 0 3 3 3 0 Peroxin 13, N-terminal region DUF2347 PF09804.9 CDI77536.1 - 7.7 6.0 7.9 6.6 6.2 1.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2347) MAS20 PF02064.15 CDI77536.1 - 7.9 6.6 20.9 9.4 6.3 9.4 2.5 2 0 0 2 2 2 0 MAS20 protein import receptor BCAS2 PF05700.11 CDI77537.1 - 4.9e-44 150.5 4.9 4.9e-44 150.5 4.9 2.9 4 0 0 4 4 4 1 Breast carcinoma amplified sequence 2 (BCAS2) Ribosomal_L16 PF00252.18 CDI77538.1 - 2.7e-41 140.6 0.0 3.4e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e AAA_16 PF13191.6 CDI77539.1 - 0.0038 17.6 0.0 0.0084 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CDI77539.1 - 0.0065 17.0 0.1 0.011 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDI77539.1 - 0.007 16.8 0.2 0.022 15.2 0.2 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 CDI77539.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 CDI77539.1 - 0.014 15.7 0.0 0.022 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDI77539.1 - 0.017 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDI77539.1 - 0.017 15.6 0.4 0.035 14.6 0.4 1.4 1 0 0 1 1 1 0 ABC transporter SRP54 PF00448.22 CDI77539.1 - 0.018 14.6 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Rad17 PF03215.15 CDI77539.1 - 0.019 14.9 0.1 0.031 14.2 0.1 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain NTPase_1 PF03266.15 CDI77539.1 - 0.019 14.9 0.3 0.041 13.8 0.2 1.5 2 0 0 2 2 2 0 NTPase AAA_28 PF13521.6 CDI77539.1 - 0.033 14.4 0.7 0.072 13.3 0.7 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDI77539.1 - 0.044 14.3 1.7 0.047 14.2 0.2 1.7 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDI77539.1 - 0.053 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 CDI77539.1 - 0.066 12.4 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 CDI77539.1 - 0.071 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 CDI77539.1 - 0.075 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 NACHT domain MobB PF03205.14 CDI77539.1 - 0.083 12.8 0.2 0.33 10.8 0.1 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CoaE PF01121.20 CDI77539.1 - 0.087 12.5 0.5 0.29 10.8 0.6 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase ATPase_2 PF01637.18 CDI77539.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Fer4_15 PF13459.6 CDI77539.1 - 0.11 13.2 0.0 0.26 12.0 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain AAA_33 PF13671.6 CDI77539.1 - 0.14 12.3 0.1 0.33 11.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 CDI77539.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain KAP_NTPase PF07693.14 CDI77539.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain cobW PF02492.19 CDI77539.1 - 0.2 11.3 0.1 0.34 10.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_M20 PF01546.28 CDI77540.1 - 2.1e-26 92.9 0.1 3.4e-26 92.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDI77540.1 - 1e-10 41.5 0.0 2.2e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M16 PF00675.20 CDI77546.1 - 7e-47 159.1 0.0 1.4e-46 158.2 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDI77546.1 - 3.6e-31 108.6 0.0 1e-30 107.1 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain zf-trcl PF13451.6 CDI77546.1 - 0.078 12.9 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Probable zinc-ribbon domain Hydrolase_4 PF12146.8 CDI77547.1 - 1.4e-13 50.7 6.1 4.2e-12 45.9 0.0 3.4 3 1 0 4 4 4 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI77547.1 - 1.5e-07 31.4 6.2 5.7e-06 26.2 0.3 3.1 2 1 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDI77547.1 - 6.6e-07 30.2 3.7 6.6e-07 30.2 3.7 3.2 2 2 0 3 3 3 1 Alpha/beta hydrolase family FSH1 PF03959.13 CDI77547.1 - 0.00023 20.9 0.0 0.00064 19.4 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) UIM PF02809.20 CDI77547.1 - 0.012 15.4 0.8 0.028 14.3 0.8 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif TFIIA PF03153.13 CDI77547.1 - 0.1 12.5 16.0 0.15 12.0 16.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI77547.1 - 0.28 10.8 34.2 0.86 9.2 3.6 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI77547.1 - 2 8.5 12.0 1.8 8.7 5.6 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Actin PF00022.19 CDI77548.1 - 2.5e-44 151.5 0.0 9.3e-41 139.8 0.0 2.7 1 1 0 1 1 1 1 Actin DiSB-ORF2_chro PF16506.5 CDI77548.1 - 0.15 12.1 1.5 2.4 8.2 0.0 2.6 2 0 0 2 2 2 0 Putative virion glycoprotein of insect viruses Mito_fiss_reg PF05308.11 CDI77549.1 - 1.4 8.9 4.7 1.4 8.9 4.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator PHD_2 PF13831.6 CDI77550.1 - 4.6e-06 26.1 8.8 0.0013 18.2 0.9 4.0 3 0 0 3 3 3 2 PHD-finger Prok-RING_1 PF14446.6 CDI77550.1 - 2.6e-05 24.1 3.5 0.018 15.0 0.8 3.1 2 0 0 2 2 2 2 Prokaryotic RING finger family 1 Dehydrin PF00257.19 CDI77550.1 - 0.04 14.5 0.0 0.04 14.5 0.0 19.4 9 4 3 15 15 15 0 Dehydrin PHD PF00628.29 CDI77550.1 - 0.075 12.9 0.0 0.0086 15.9 1.6 5.6 6 0 0 6 6 6 0 PHD-finger NFACT-R_2 PF18297.1 CDI77550.1 - 0.75 10.0 5.7 0.15 12.2 0.2 2.8 2 0 0 2 2 2 0 NFACT protein RNA binding domain DUF2722 PF10846.8 CDI77551.1 - 0.0013 17.8 11.0 0.0013 17.8 11.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI77551.1 - 0.014 15.7 13.8 0.014 15.7 13.8 4.3 1 1 2 3 3 1 0 Anti-sigma-K factor rskA DUF4471 PF14740.6 CDI77551.1 - 0.42 9.8 6.9 0.24 10.6 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) HNOBA PF07701.14 CDI77551.1 - 0.75 9.2 9.6 3.3 7.1 1.1 2.3 2 0 0 2 2 2 0 Heme NO binding associated PA26 PF04636.13 CDI77551.1 - 1.6 7.6 12.8 0.92 8.4 5.8 2.0 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Connexin PF00029.19 CDI77551.1 - 1.9 8.2 9.0 5.5 6.7 4.2 2.2 2 0 0 2 2 2 0 Connexin Hamartin PF04388.12 CDI77551.1 - 4.1 5.9 18.6 4.7 5.8 18.6 1.1 1 0 0 1 1 1 0 Hamartin protein LMBR1 PF04791.16 CDI77551.1 - 4.2 6.2 3.8 5 5.9 3.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Merozoite_SPAM PF07133.11 CDI77551.1 - 5.3 7.0 25.9 4.2 7.3 11.9 2.2 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Pet20 PF08692.10 CDI77551.1 - 6.8 7.4 7.7 13 6.5 0.4 2.3 2 0 0 2 2 2 0 Mitochondrial protein Pet20 BSP_II PF05432.11 CDI77551.1 - 7.4 6.2 24.6 2.8 7.6 3.8 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SOG2 PF10428.9 CDI77553.1 - 0.19 10.9 5.6 0.23 10.7 5.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2981 PF11200.8 CDI77553.1 - 0.39 10.4 2.3 0.51 10.0 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Med15 PF09606.10 CDI77554.1 - 0.01 14.6 15.8 0.013 14.3 15.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TPR_14 PF13428.6 CDI77554.1 - 0.012 16.4 5.0 1.2 10.1 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat HHH_8 PF14716.6 CDI77554.1 - 0.02 15.2 0.6 0.038 14.4 0.6 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF935 PF06074.12 CDI77554.1 - 0.047 12.4 7.0 0.072 11.8 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF935) Fmp27_WPPW PF10359.9 CDI77554.1 - 0.056 12.3 9.9 0.07 12.0 9.9 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SPX PF03105.19 CDI77554.1 - 0.14 12.1 15.6 0.22 11.4 15.6 1.2 1 0 0 1 1 1 0 SPX domain FPN1 PF06963.12 CDI77554.1 - 0.29 9.6 3.5 0.54 8.8 3.5 1.4 1 0 0 1 1 1 0 Ferroportin1 (FPN1) MGC-24 PF05283.11 CDI77554.1 - 0.53 10.7 11.5 0.23 11.9 9.3 1.5 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin RapH_N PF18801.1 CDI77554.1 - 0.71 10.0 4.5 1.1 9.4 2.0 2.1 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal XRN_M PF17846.1 CDI77554.1 - 0.76 8.7 7.4 0.13 11.2 3.5 1.5 2 0 0 2 2 2 0 Xrn1 helical domain ANAPC_CDC26 PF10471.9 CDI77554.1 - 0.8 10.6 24.4 1.8 9.4 1.7 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DUF1003 PF06210.11 CDI77554.1 - 1.4 9.1 7.9 2.6 8.2 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Jnk-SapK_ap_N PF09744.9 CDI77554.1 - 3.6 7.8 20.4 3.8 7.7 19.3 1.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 CDI77554.1 - 4.2 6.6 9.1 5.1 6.4 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Kei1 PF08552.11 CDI77554.1 - 5.7 6.8 7.0 5.9 6.7 0.2 2.1 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 TPPII_N PF12583.8 CDI77554.1 - 9.5 6.8 12.0 22 5.6 12.0 1.5 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Syntaxin PF00804.25 CDI77555.1 - 2.5e-07 30.6 11.1 2e-05 24.4 11.1 2.1 1 1 0 1 1 1 1 Syntaxin HMW1C_N PF18071.1 CDI77555.1 - 0.0097 15.7 0.2 0.021 14.6 0.2 1.5 1 0 0 1 1 1 1 HMW1C N-terminal DnaJ PF00226.31 CDI77555.1 - 0.15 12.2 3.5 15 5.8 0.1 3.6 4 0 0 4 4 4 0 DnaJ domain Syntaxin_2 PF14523.6 CDI77555.1 - 0.22 11.9 6.7 0.16 12.4 4.4 1.9 2 0 0 2 2 2 0 Syntaxin-like protein Exonuc_VII_L PF02601.15 CDI77557.1 - 1.6 8.3 28.9 2.1 7.9 28.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TFIIA PF03153.13 CDI77557.1 - 4.9 7.1 60.6 7 6.5 60.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mem_trans PF03547.18 CDI77557.1 - 8.6 4.6 9.1 15 3.9 9.1 1.3 1 0 0 1 1 1 0 Membrane transport protein eIF2A PF08662.11 CDI77559.1 - 2.6e-28 99.2 4.7 4.1e-25 88.8 1.1 2.8 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CDI77559.1 - 0.0001 22.0 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SR-25 PF10500.9 CDI77560.1 - 4.5e-05 23.2 7.6 4.5e-05 23.2 7.6 16.1 9 4 5 15 15 15 4 Nuclear RNA-splicing-associated protein Cullin PF00888.22 CDI77560.1 - 0.0012 17.6 53.1 3.1 6.3 0.0 6.6 4 1 1 5 5 5 5 Cullin family eIF-3_zeta PF05091.12 CDI77561.1 - 3.3e-44 151.8 0.9 8.6e-30 104.2 0.1 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ATP_bind_1 PF03029.17 CDI77562.1 - 1.1e-55 189.1 0.0 2.6e-55 187.8 0.0 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 CDI77562.1 - 5.8e-05 23.5 0.0 5.8e-05 23.5 0.0 3.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 CDI77562.1 - 9.6e-05 22.9 0.4 0.002 18.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CDI77562.1 - 0.00043 20.0 0.0 0.0014 18.3 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDI77562.1 - 0.00084 19.6 0.0 0.0023 18.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDI77562.1 - 0.0009 19.2 0.0 0.0031 17.4 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 CDI77562.1 - 0.0055 16.5 0.0 0.051 13.3 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 CDI77562.1 - 0.019 15.0 0.0 0.06 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDI77562.1 - 0.051 14.0 0.0 0.18 12.2 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDI77562.1 - 0.12 11.9 0.0 0.32 10.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase PF00069.25 CDI77563.1 - 3e-17 62.9 0.0 2.3e-16 60.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77563.1 - 2.3e-07 30.4 0.0 4.3e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase CCDC53 PF10152.9 CDI77563.1 - 0.69 10.3 3.5 1.7 9.1 3.5 1.6 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Pkinase PF00069.25 CDI77564.1 - 1.9e-15 57.0 0.0 3.2e-14 52.9 0.0 2.8 2 1 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CDI77564.1 - 4.6e-07 29.4 0.5 1.9e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_Tyr PF07714.17 CDI77564.1 - 5.5e-05 22.6 0.2 0.00036 19.9 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CDI77564.1 - 0.00038 19.9 1.9 0.0025 17.2 0.0 2.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI77564.1 - 0.0043 17.0 1.4 0.0043 17.0 1.4 4.0 2 2 1 3 3 3 1 Phosphotransferase enzyme family FPN1 PF06963.12 CDI77564.1 - 0.12 10.9 0.0 0.26 9.8 0.0 1.5 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Pkinase_fungal PF17667.1 CDI77564.1 - 0.15 10.8 0.4 0.39 9.4 0.4 1.9 1 1 0 1 1 1 0 Fungal protein kinase BAF1_ABF1 PF04684.13 CDI77568.1 - 0.17 10.9 33.1 0.23 10.5 33.1 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SRP-alpha_N PF04086.13 CDI77568.1 - 1.1 9.1 33.4 1.5 8.7 33.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal BSP_II PF05432.11 CDI77568.1 - 2.8 7.6 32.4 4.1 7.0 32.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Glyco_hydro_31 PF01055.26 CDI77569.1 - 9.6e-60 203.0 0.0 5.6e-58 197.2 0.0 5.2 5 2 1 6 6 6 2 Glycosyl hydrolases family 31 DUF5110 PF17137.4 CDI77569.1 - 1.6e-06 28.3 0.0 4.4e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Gal_mutarotas_2 PF13802.6 CDI77569.1 - 2.7e-05 24.4 0.0 6.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Galactose mutarotase-like AF-4 PF05110.13 CDI77570.1 - 2 6.4 36.6 3.6 5.5 36.6 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein eIF-3_zeta PF05091.12 CDI77571.1 - 5.6 5.8 13.6 8.5 5.2 13.6 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Membralin PF09746.9 CDI77571.1 - 8.7 5.3 7.7 13 4.6 7.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein Spt20 PF12090.8 CDI77572.1 - 2.2 7.8 9.6 0.89 9.1 4.6 2.3 2 0 0 2 2 2 0 Spt20 family PAP1 PF08601.10 CDI77575.1 - 0.0033 17.2 7.1 0.0033 17.2 7.1 8.7 7 3 0 9 9 9 1 Transcription factor PAP1 DUF3371 PF11851.8 CDI77575.1 - 0.013 16.6 0.8 0.013 16.6 0.8 12.4 9 6 0 10 10 10 0 Domain of unknown function (DUF3371) Spore_YhcN_YlaJ PF09580.10 CDI77575.1 - 0.14 12.2 7.9 2.2 8.4 1.4 3.6 2 1 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Parvo_coat PF00740.18 CDI77577.1 - 1.3 7.6 11.0 1.5 7.4 11.0 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP2 tRNA-synt_2 PF00152.20 CDI77579.1 - 1.5e-68 231.2 0.0 2.2e-68 230.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CDI77579.1 - 0.0026 17.3 0.3 2.4 7.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Cohesin_HEAT PF12765.7 CDI77581.1 - 0.035 14.4 0.3 2.2 8.6 0.0 3.1 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion RICTOR_N PF14664.6 CDI77582.1 - 2.4e-05 23.5 13.1 0.025 13.6 0.7 4.7 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 CDI77582.1 - 0.023 14.5 0.1 0.069 12.9 0.0 1.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain DUF4667 PF15700.5 CDI77582.1 - 0.63 10.1 0.0 0.63 10.1 0.0 10.8 7 3 1 10 10 10 0 Domain of unknown function (DUF4667) CbiG_mid PF11761.8 CDI77583.1 - 0.32 11.1 2.4 2.2 8.5 0.2 3.8 2 0 0 2 2 2 0 Cobalamin biosynthesis central region ATP-synt_ab_C PF00306.27 CDI77586.1 - 1.6e-35 122.2 2.1 1.1e-34 119.4 2.1 1.8 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ABC1 PF03109.16 CDI77587.1 - 2e-25 89.3 0.0 5.2e-25 87.9 0.0 1.8 1 0 0 1 1 1 1 ABC1 family Activator_LAG-3 PF11498.8 CDI77588.1 - 0.0015 17.6 4.1 0.0015 17.6 4.1 9.7 8 3 2 10 10 10 2 Transcriptional activator LAG-3 ISN1 PF06437.11 CDI77591.1 - 3.6e-34 118.4 0.0 3.6e-34 118.4 0.0 1.5 2 0 0 2 2 1 1 IMP-specific 5'-nucleotidase DUF2722 PF10846.8 CDI77591.1 - 0.00036 19.6 8.0 0.00036 19.6 8.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI77591.1 - 0.013 15.8 5.9 0.18 12.2 1.2 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like AA_kinase PF00696.28 CDI77591.1 - 0.24 10.9 0.1 0.24 10.9 0.1 2.1 2 1 0 2 2 2 0 Amino acid kinase family Otopetrin PF03189.13 CDI77591.1 - 0.33 9.7 1.1 0.51 9.1 1.1 1.3 1 0 0 1 1 1 0 Otopetrin FragX_IP PF05994.11 CDI77591.1 - 0.34 8.9 1.6 0.5 8.4 1.6 1.2 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family TFIIA PF03153.13 CDI77591.1 - 0.54 10.2 34.6 1.5 8.7 3.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit E7 PF00527.18 CDI77591.1 - 0.9 9.8 6.1 2.6 8.3 0.9 2.6 2 0 0 2 2 2 0 E7 protein, Early protein EOS1 PF12326.8 CDI77591.1 - 2.1 8.2 7.0 13 5.6 0.0 2.2 2 0 0 2 2 2 0 N-glycosylation protein Ufd2P_core PF10408.9 CDI77591.1 - 4.6 5.7 10.6 5.3 5.5 0.9 2.1 2 0 0 2 2 2 0 Ubiquitin elongating factor core Tim54 PF11711.8 CDI77591.1 - 4.8 5.9 11.7 1.9 7.2 0.2 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Band_3_cyto PF07565.13 CDI77591.1 - 7.8 6.2 7.9 2 8.1 2.3 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain adh_short PF00106.25 CDI77593.1 - 0.00022 20.7 2.4 0.07 12.6 0.1 2.5 2 1 0 2 2 2 2 short chain dehydrogenase RAP1 PF07218.11 CDI77593.1 - 0.96 7.6 11.9 1.3 7.3 11.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RT_RNaseH_2 PF17919.1 CDI77594.1 - 1.1e-27 96.0 0.0 2.1e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI77594.1 - 4.2e-27 94.5 0.0 7.6e-27 93.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDI77594.1 - 7.9e-05 22.3 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TFIIA PF03153.13 CDI77600.1 - 0.051 13.6 57.8 0.026 14.5 33.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 CDI77600.1 - 0.17 12.8 0.2 0.17 12.8 0.2 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4228 PF14009.6 CDI77600.1 - 1.4 9.2 19.7 2.3 8.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Bacteriocin_IIc PF10439.9 CDI77600.1 - 2.3 8.4 22.6 3.8 7.7 22.6 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide RR_TM4-6 PF06459.12 CDI77600.1 - 9.1 6.0 30.1 2.5 7.8 2.0 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Epimerase PF01370.21 CDI77601.1 - 1.2e-31 110.0 0.0 5.6e-26 91.5 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDI77601.1 - 3.3e-05 23.4 0.0 0.00014 21.3 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDI77601.1 - 5.4e-05 22.4 0.0 8.5e-05 21.8 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDI77601.1 - 0.0013 17.9 0.1 0.0027 16.9 0.0 1.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Tup_N PF08581.10 CDI77602.1 - 0.011 16.1 7.9 0.011 16.1 7.9 3.6 3 0 0 3 3 3 0 Tup N-terminal Phage_GP20 PF06810.11 CDI77602.1 - 5 6.9 24.1 0.37 10.6 6.4 4.2 3 1 1 4 4 4 0 Phage minor structural protein GP20 FapA PF03961.13 CDI77602.1 - 6 5.4 17.6 1.1 7.8 0.1 2.7 2 1 1 3 3 3 0 Flagellar Assembly Protein A BRCT_3 PF18428.1 CDI77603.1 - 0.0022 18.1 0.0 0.41 10.7 0.0 3.6 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDI77603.1 - 0.025 15.0 0.0 2.1 8.8 0.0 2.9 3 0 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CDI77603.1 - 0.042 14.2 0.4 1.5 9.3 0.0 3.1 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain TIP49 PF06068.13 CDI77604.1 - 1.1e-104 350.5 5.0 8.5e-53 179.8 0.4 3.1 1 1 2 3 3 3 3 TIP49 P-loop domain TIP49_C PF17856.1 CDI77604.1 - 1.1e-19 70.4 0.1 7.4e-19 67.7 0.0 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CDI77604.1 - 0.0018 18.7 0.1 0.0049 17.3 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI77604.1 - 0.0064 16.3 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 CDI77604.1 - 0.021 14.4 0.2 0.063 12.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDI77604.1 - 0.052 13.5 0.1 0.095 12.7 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE gag-asp_proteas PF13975.6 CDI77605.1 - 0.029 14.9 0.0 0.095 13.3 0.0 1.9 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDI77605.1 - 0.053 14.2 0.0 0.18 12.5 0.0 1.8 2 0 0 2 2 2 0 Aspartyl protease RVP PF00077.20 CDI77605.1 - 0.14 12.5 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Med15 PF09606.10 CDI77606.1 - 0.00057 18.7 64.5 0.00057 18.7 64.5 4.9 2 1 2 4 4 4 1 ARC105 or Med15 subunit of Mediator complex non-fungal RskA PF10099.9 CDI77607.1 - 0.034 14.5 12.8 0.026 14.8 11.4 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Glt_symporter PF03616.14 CDI77607.1 - 0.14 10.8 0.2 0.23 10.1 0.2 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter FHIPEP PF00771.20 CDI77607.1 - 0.36 9.3 2.7 0.65 8.4 2.7 1.3 1 0 0 1 1 1 0 FHIPEP family RskA PF10099.9 CDI77608.1 - 0.025 14.9 1.6 0.025 14.9 1.6 4.2 2 1 2 4 4 4 0 Anti-sigma-K factor rskA LCD1 PF09798.9 CDI77608.1 - 0.28 9.7 25.7 49 2.2 25.7 2.4 1 1 0 1 1 1 0 DNA damage checkpoint protein DUF4422 PF14393.6 CDI77608.1 - 7.5 6.3 8.7 0.31 10.8 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4422) TFIIA PF03153.13 CDI77609.1 - 3.4e-06 27.3 7.6 2.1e-05 24.8 6.7 2.2 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI77609.1 - 0.74 9.9 17.9 0.081 13.0 4.9 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Radial_spoke_3 PF06098.11 CDI77609.1 - 6.8 5.9 9.6 0.56 9.4 1.7 2.1 2 0 0 2 2 2 0 Radial spoke protein 3 RskA PF10099.9 CDI77610.1 - 4.5e-07 30.4 8.5 7.8e-07 29.6 8.5 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA SpoVR PF04293.13 CDI77610.1 - 0.005 15.6 3.5 0.0056 15.4 3.5 1.1 1 0 0 1 1 1 1 SpoVR like protein DUF4834 PF16118.5 CDI77610.1 - 0.07 14.1 4.7 0.13 13.2 4.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI77610.1 - 0.18 10.6 3.8 0.19 10.4 3.8 1.1 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI77610.1 - 0.27 10.8 23.4 0.41 10.2 23.4 1.2 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI77610.1 - 0.6 8.5 11.9 0.74 8.2 11.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2722 PF10846.8 CDI77610.1 - 1 8.2 20.9 1.9 7.3 20.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RBM39linker PF15519.6 CDI77610.1 - 1.7 9.8 14.6 2.2 9.4 1.7 2.2 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Coilin_N PF15862.5 CDI77610.1 - 2.3 8.0 10.8 3.6 7.4 10.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus DUF3464 PF11947.8 CDI77610.1 - 5.3 6.8 8.9 12 5.6 6.5 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 dCMP_cyt_deam_2 PF08211.12 CDI77612.1 - 4.8e-12 46.2 8.3 4.8e-12 46.2 8.3 3.1 3 1 0 3 3 3 2 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 PF00383.23 CDI77612.1 - 2.8e-06 27.1 10.4 0.0015 18.3 4.7 2.8 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Band_3_cyto PF07565.13 CDI77612.1 - 0.037 13.8 2.7 0.046 13.5 2.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Stn1 PF10451.9 CDI77612.1 - 0.089 11.7 1.7 0.13 11.2 1.7 1.2 1 0 0 1 1 1 0 Telomere regulation protein Stn1 Imm5 PF14423.6 CDI77612.1 - 0.33 11.2 0.1 0.33 11.2 0.1 2.1 3 0 0 3 3 3 0 Immunity protein Imm5 V_ATPase_I PF01496.19 CDI77612.1 - 0.39 8.6 4.2 0.48 8.3 4.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spore_YhcN_YlaJ PF09580.10 CDI77612.1 - 0.99 9.5 4.9 1.9 8.5 4.9 1.4 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) TFIIA PF03153.13 CDI77612.1 - 5 7.0 26.3 0.44 10.5 21.8 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Adaptin_N PF01602.20 CDI77613.1 - 1.1e-31 110.1 24.7 3.9e-26 91.7 1.7 6.3 4 2 1 5 5 5 4 Adaptin N terminal region Cnd1 PF12717.7 CDI77613.1 - 0.0024 17.9 0.5 0.0024 17.9 0.5 3.6 4 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 gerPA PF10676.9 CDI77613.1 - 1.1 9.6 3.5 3.7 7.9 0.2 2.8 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF HicB_lk_antitox PF15919.5 CDI77614.1 - 0.13 12.4 1.4 0.15 12.2 1.4 1.2 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system BAF1_ABF1 PF04684.13 CDI77614.1 - 0.18 10.8 13.9 0.2 10.7 13.9 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor P5-ATPase PF12409.8 CDI77614.1 - 0.22 11.6 5.2 0.24 11.5 5.2 1.0 1 0 0 1 1 1 0 P5-type ATPase cation transporter Pex14_N PF04695.13 CDI77614.1 - 0.58 10.8 22.5 0.58 10.8 22.5 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SelP_N PF04592.14 CDI77614.1 - 0.65 9.4 14.4 0.7 9.2 14.4 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Velvet PF11754.8 CDI77614.1 - 1 9.3 12.5 0.99 9.3 12.5 1.0 1 0 0 1 1 1 0 Velvet factor Bac_luciferase PF00296.20 CDI77614.1 - 1 8.7 8.1 1.1 8.6 8.1 1.0 1 0 0 1 1 1 0 Luciferase-like monooxygenase HNOBA PF07701.14 CDI77614.1 - 1.2 8.5 13.6 1.3 8.4 13.6 1.1 1 0 0 1 1 1 0 Heme NO binding associated RNA_pol_Rpc4 PF05132.14 CDI77614.1 - 1.4 9.4 15.8 1.5 9.2 15.8 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 CDI77614.1 - 1.4 7.6 17.7 1.5 7.5 17.7 1.0 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CDI77614.1 - 1.4 8.3 16.3 1.5 8.3 16.3 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) NARP1 PF12569.8 CDI77614.1 - 1.4 7.7 17.5 1.5 7.7 17.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AIF_C PF14721.6 CDI77614.1 - 1.4 9.2 12.3 1.8 8.9 12.3 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Peptidase_S49_N PF08496.10 CDI77614.1 - 1.4 8.9 14.3 1.6 8.8 14.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Methyltransf_32 PF13679.6 CDI77614.1 - 1.5 8.8 12.5 1.6 8.7 12.5 1.0 1 0 0 1 1 1 0 Methyltransferase domain Pal1 PF08316.11 CDI77614.1 - 1.5 9.6 7.6 1.7 9.4 7.6 1.1 1 0 0 1 1 1 0 Pal1 cell morphology protein Peptidase_U57 PF05582.12 CDI77614.1 - 2 7.6 12.2 2.2 7.5 12.2 1.0 1 0 0 1 1 1 0 YabG peptidase U57 DUF4228 PF14009.6 CDI77614.1 - 2 8.8 9.2 2.1 8.7 9.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF4820 PF16091.5 CDI77614.1 - 2 7.7 11.4 2.3 7.5 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Eapp_C PF10238.9 CDI77614.1 - 2.1 8.4 15.0 2.4 8.2 15.0 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Nop53 PF07767.11 CDI77614.1 - 2.2 7.6 22.7 2.5 7.4 22.7 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF1764 PF08576.10 CDI77614.1 - 2.4 9.1 14.0 2.8 8.9 14.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TFIIA PF03153.13 CDI77614.1 - 2.4 8.1 35.9 2.4 8.0 35.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Baculo_PP31 PF05311.11 CDI77614.1 - 2.7 7.4 14.1 2.9 7.3 14.1 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Ureide_permease PF07168.11 CDI77614.1 - 2.8 6.6 8.5 2.9 6.5 8.5 1.0 1 0 0 1 1 1 0 Ureide permease Tim54 PF11711.8 CDI77614.1 - 3 6.5 14.7 3.2 6.4 14.7 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 CDI77614.1 - 3 7.8 11.5 3.2 7.8 11.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI77614.1 - 3.1 7.8 19.6 3.5 7.6 19.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Suf PF05843.14 CDI77614.1 - 3.2 7.7 18.0 3.5 7.5 18.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Coilin_N PF15862.5 CDI77614.1 - 3.4 7.5 19.8 4.4 7.1 19.8 1.2 1 0 0 1 1 1 0 Coilin N-terminus Band_3_cyto PF07565.13 CDI77614.1 - 3.4 7.4 13.5 3.9 7.2 13.5 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MDM31_MDM32 PF08118.11 CDI77614.1 - 3.5 6.2 11.3 3.5 6.2 11.3 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins RR_TM4-6 PF06459.12 CDI77614.1 - 3.6 7.3 17.8 4 7.2 17.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI77614.1 - 3.7 5.7 14.2 4.1 5.6 14.2 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 CDI77614.1 - 3.7 7.5 11.3 3.9 7.4 11.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A FHIPEP PF00771.20 CDI77614.1 - 3.7 5.9 9.3 3.3 6.1 9.3 1.1 1 0 0 1 1 1 0 FHIPEP family R_equi_Vir PF05526.11 CDI77614.1 - 3.8 7.3 9.3 4.5 7.1 9.3 1.0 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Rxt3 PF08642.10 CDI77614.1 - 3.9 8.3 8.8 4.5 8.1 8.8 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Sec62 PF03839.16 CDI77614.1 - 3.9 6.9 11.9 4.1 6.9 11.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 EIIBC-GUT_N PF03612.14 CDI77614.1 - 4.1 7.1 15.2 4.5 7.0 15.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Connexin PF00029.19 CDI77614.1 - 4.2 7.1 12.9 4.3 7.0 12.9 1.0 1 0 0 1 1 1 0 Connexin CobT PF06213.12 CDI77614.1 - 4.2 6.7 23.5 4.9 6.5 23.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3408 PF11888.8 CDI77614.1 - 4.3 7.5 16.1 5 7.3 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF4638 PF15472.6 CDI77614.1 - 4.9 6.8 12.4 4.9 6.8 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Rtf2 PF04641.12 CDI77614.1 - 4.9 6.4 15.8 5.5 6.3 15.8 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2828 PF11443.8 CDI77614.1 - 5.1 5.0 14.6 5.4 5.0 14.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) EOS1 PF12326.8 CDI77614.1 - 5.2 7.0 9.2 5.8 6.8 9.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein Spt20 PF12090.8 CDI77614.1 - 5.4 6.5 37.0 7.2 6.1 37.0 1.3 1 0 0 1 1 1 0 Spt20 family MAJIN PF15077.6 CDI77614.1 - 5.7 6.7 9.8 6.2 6.5 9.8 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein DDHD PF02862.17 CDI77614.1 - 5.8 7.0 15.4 6.4 6.9 15.4 1.0 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.6 CDI77614.1 - 6 7.0 15.8 6.7 6.9 15.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal G0-G1_switch_2 PF15103.6 CDI77614.1 - 6.1 7.3 11.9 8.3 6.9 11.9 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 CSG2 PF16965.5 CDI77614.1 - 6.3 5.6 9.4 6.8 5.5 9.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator PAT1 PF09770.9 CDI77614.1 - 6.6 4.9 24.0 7 4.8 24.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3464 PF11947.8 CDI77614.1 - 6.8 6.4 16.1 7.9 6.2 16.1 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 eIF-3_zeta PF05091.12 CDI77614.1 - 7.1 5.5 20.0 7.5 5.4 20.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pannexin_like PF12534.8 CDI77614.1 - 7.2 5.6 10.8 7.5 5.5 10.8 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 eIF3_subunit PF08597.10 CDI77614.1 - 7.5 6.4 21.3 8.4 6.2 21.3 1.0 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Gti1_Pac2 PF09729.9 CDI77614.1 - 7.5 6.6 13.3 8.5 6.4 13.3 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family NPR3 PF03666.13 CDI77614.1 - 8.2 5.1 15.0 9 5.0 15.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1980 PF09323.10 CDI77614.1 - 8.3 6.3 12.2 8.8 6.2 12.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CTU2 PF10288.9 CDI77614.1 - 8.3 6.7 14.1 11 6.3 14.1 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 V_ATPase_I PF01496.19 CDI77614.1 - 8.8 4.1 16.0 8.7 4.1 16.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2126 PF09899.9 CDI77614.1 - 9.1 4.2 13.1 9.2 4.2 13.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Peroxin-13_N PF04088.13 CDI77614.1 - 9.7 6.5 9.2 11 6.2 9.2 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM176 PF14851.6 CDI77614.1 - 9.9 5.8 11.1 11 5.6 11.1 1.1 1 0 0 1 1 1 0 FAM176 family SR-25 PF10500.9 CDI77615.1 - 1.7e-06 27.8 8.6 2.6e-06 27.2 8.6 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI77615.1 - 0.00052 20.1 24.9 0.00077 19.6 24.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SOBP PF15279.6 CDI77615.1 - 0.012 16.3 14.2 0.015 15.9 14.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Suf PF05843.14 CDI77615.1 - 0.021 14.8 16.6 0.027 14.4 16.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) eIF-3_zeta PF05091.12 CDI77615.1 - 0.025 13.6 6.6 0.031 13.3 6.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Utp14 PF04615.13 CDI77615.1 - 0.057 12.0 12.0 0.067 11.8 12.0 1.0 1 0 0 1 1 1 0 Utp14 protein Spore_YhcN_YlaJ PF09580.10 CDI77615.1 - 0.26 11.4 9.2 0.36 10.9 9.2 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Hydin_ADK PF17213.3 CDI77615.1 - 0.27 11.5 15.0 0.45 10.8 15.0 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Ndc1_Nup PF09531.10 CDI77615.1 - 0.69 8.5 21.0 0.83 8.3 21.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NifQ PF04891.12 CDI77615.1 - 0.75 10.1 7.5 0.15 12.4 3.4 1.8 1 1 0 2 2 2 0 NifQ DUF572 PF04502.13 CDI77615.1 - 0.89 9.1 13.6 1.4 8.5 13.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) FAM60A PF15396.6 CDI77615.1 - 1.1 9.3 10.3 1.5 8.8 10.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A PA26 PF04636.13 CDI77615.1 - 1.1 8.1 8.2 1.4 7.8 8.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PIP5K PF01504.18 CDI77615.1 - 1.1 8.4 7.3 1.5 8.0 7.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Presenilin PF01080.17 CDI77615.1 - 1.3 7.7 18.7 1.7 7.3 18.7 1.2 1 0 0 1 1 1 0 Presenilin XRCC4 PF06632.12 CDI77615.1 - 1.3 7.8 10.9 1.8 7.4 10.9 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SLC12 PF03522.15 CDI77615.1 - 1.5 7.8 12.1 2 7.3 12.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Med15 PF09606.10 CDI77615.1 - 1.7 7.3 29.9 2.7 6.6 29.9 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3295 PF11702.8 CDI77615.1 - 3.4 6.9 22.9 4.5 6.5 22.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Peptidase_S64 PF08192.11 CDI77615.1 - 3.9 5.8 13.2 5.1 5.5 13.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.7 CDI77615.1 - 4.3 5.3 15.8 5 5.1 15.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DivIC PF04977.15 CDI77615.1 - 4.6 7.1 14.5 8.4 6.3 14.5 1.4 1 0 0 1 1 1 0 Septum formation initiator GREB1 PF15782.5 CDI77615.1 - 4.8 4.2 18.4 6 3.8 18.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 CDI77615.1 - 4.8 6.3 21.3 7.8 5.6 21.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SMYLE_N PF18615.1 CDI77615.1 - 5.7 6.4 13.3 8.3 5.9 13.3 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CKS PF01111.19 CDI77617.1 - 1.5e-12 47.5 0.0 8.9e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Cyclin-dependent kinase regulatory subunit TFIIA PF03153.13 CDI77617.1 - 0.002 18.2 35.0 0.002 18.2 35.0 3.9 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 CDI77617.1 - 1 8.1 26.1 0.15 10.9 6.2 3.2 3 0 0 3 3 3 0 Golgi-body localisation protein domain Suf PF05843.14 CDI77617.1 - 1.4 8.8 21.6 0.022 14.7 10.9 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PAT1 PF09770.9 CDI77617.1 - 6.2 4.9 28.9 0.094 11.0 21.2 1.8 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Ribosomal_L15e PF00827.17 CDI77618.1 - 6.7e-87 290.2 10.1 7.6e-87 290.0 10.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 Trp_oprn_chp PF09534.10 CDI77619.1 - 0.0057 16.5 1.4 0.0065 16.3 1.4 1.0 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3824 PF12868.7 CDI77619.1 - 0.05 14.3 1.1 0.064 13.9 1.1 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Methyltransf_12 PF08242.12 CDI77621.1 - 2.9e-10 40.8 0.5 7.2e-07 29.9 0.0 3.1 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 CDI77621.1 - 4e-07 30.6 6.6 2e-05 25.2 0.1 3.2 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_23 PF13489.6 CDI77621.1 - 1.1e-06 28.5 0.2 8.1e-06 25.8 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDI77621.1 - 4.7e-05 23.0 0.1 0.00012 21.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDI77621.1 - 0.00021 21.9 0.8 0.19 12.4 0.0 3.2 3 0 0 3 3 3 1 Methyltransferase domain RskA PF10099.9 CDI77621.1 - 0.0018 18.6 1.5 0.0018 18.6 1.5 3.2 1 1 2 3 3 3 1 Anti-sigma-K factor rskA Methyltransf_31 PF13847.6 CDI77621.1 - 0.0076 16.1 0.2 0.025 14.4 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Spt20 PF12090.8 CDI77621.1 - 0.07 12.7 11.7 0.12 12.0 11.7 1.3 1 0 0 1 1 1 0 Spt20 family Methyltransf_2 PF00891.18 CDI77621.1 - 0.12 11.6 0.1 0.34 10.2 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain RAB3GAP2_N PF14655.6 CDI77621.1 - 0.31 10.3 4.3 0.5 9.6 4.3 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus MscS_TM PF12794.7 CDI77621.1 - 1.7 7.4 5.4 3.6 6.4 5.4 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Presenilin PF01080.17 CDI77621.1 - 1.7 7.3 3.8 2.8 6.6 3.8 1.3 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI77621.1 - 3.8 6.3 13.2 0.58 9.0 7.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SPX PF03105.19 CDI77621.1 - 4.2 7.2 8.7 18 5.1 0.2 2.0 2 0 0 2 2 2 0 SPX domain ANAPC_CDC26 PF10471.9 CDI77621.1 - 5.9 7.8 16.7 1.6 9.6 12.6 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 PTPRCAP PF15713.5 CDI77621.1 - 9.4 6.5 19.5 0.89 9.8 14.2 2.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF3273 PF11677.8 CDI77623.1 - 4.2e-103 344.3 7.4 4.9e-103 344.1 7.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) SR-25 PF10500.9 CDI77625.1 - 0.0015 18.2 12.3 0.0015 18.2 12.3 3.2 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Exo_endo_phos PF03372.23 CDI77625.1 - 0.0077 15.8 0.0 0.025 14.1 0.0 1.9 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family EamA PF00892.20 CDI77626.1 - 0.0018 18.4 8.7 0.0018 18.4 8.7 3.0 3 0 0 3 3 3 1 EamA-like transporter family Presenilin PF01080.17 CDI77626.1 - 0.0055 15.5 1.3 0.0099 14.7 1.3 1.4 1 0 0 1 1 1 1 Presenilin SAGA-Tad1 PF12767.7 CDI77626.1 - 0.53 10.0 5.1 0.83 9.3 5.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit CCDC53 PF10152.9 CDI77626.1 - 7.3 7.0 16.6 0.15 12.4 1.4 2.9 1 1 1 2 2 2 0 Subunit CCDC53 of WASH complex DUF4805 PF16063.5 CDI77627.1 - 0.014 14.8 8.2 0.016 14.5 8.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) DUF2052 PF09747.9 CDI77627.1 - 1.1 9.3 13.0 1.3 9.1 13.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PAT1 PF09770.9 CDI77627.1 - 3.7 5.7 21.6 4.3 5.5 21.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Band_3_cyto PF07565.13 CDI77627.1 - 6.3 6.5 10.8 8.1 6.2 10.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF1180 PF06679.12 CDI77627.1 - 6.9 7.1 10.2 2 8.8 6.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) RR_TM4-6 PF06459.12 CDI77627.1 - 7.2 6.3 10.8 8.4 6.1 10.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI77627.1 - 8.3 6.4 10.0 10 6.1 10.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DNA_primase_S PF01896.19 CDI77629.1 - 4.1e-41 141.0 0.0 8.6e-41 139.9 0.0 1.5 1 1 0 1 1 1 1 DNA primase small subunit XTBD PF11952.8 CDI77629.1 - 0.094 12.5 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD tRNA-synt_1 PF00133.22 CDI77630.1 - 3.6e-192 639.8 0.0 3.6e-192 639.8 0.0 1.5 2 0 0 2 2 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDI77630.1 - 1.3e-23 83.6 0.1 3.4e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDI77630.1 - 7.4e-19 67.8 0.1 2.6e-07 29.7 0.0 3.5 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CDI77630.1 - 6.6e-05 22.4 0.0 6.6e-05 22.4 0.0 2.2 3 0 0 3 3 2 1 tRNA synthetases class I (C) catalytic domain DDHD PF02862.17 CDI77630.1 - 0.021 15.0 3.0 0.048 13.8 3.0 1.6 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.10 CDI77630.1 - 0.022 13.5 27.8 0.04 12.6 27.8 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal VIT1 PF01988.19 CDI77630.1 - 1.2 9.0 6.9 6.9 6.5 5.9 2.3 2 0 0 2 2 2 0 VIT family ATP11 PF06644.11 CDI77630.1 - 1.4 8.7 18.4 0.86 9.3 15.9 1.8 2 0 0 2 2 2 0 ATP11 protein eIF-3_zeta PF05091.12 CDI77630.1 - 1.5 7.7 16.3 2.4 7.0 16.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ndc1_Nup PF09531.10 CDI77630.1 - 1.7 7.2 8.9 3.1 6.4 8.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 CDI77630.1 - 2.2 8.9 25.5 4.7 7.9 25.5 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI77630.1 - 2.9 7.8 39.2 0.081 12.9 32.7 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Gti1_Pac2 PF09729.9 CDI77630.1 - 3.5 7.7 10.2 8.6 6.4 10.2 1.6 1 0 0 1 1 1 0 Gti1/Pac2 family EPL1 PF10513.9 CDI77630.1 - 6.9 7.0 12.9 17 5.7 12.9 1.6 1 0 0 1 1 1 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 CDI77630.1 - 7 6.6 11.8 37 4.3 10.2 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI77630.1 - 7.3 5.2 16.8 12 4.5 16.8 1.2 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.10 CDI77631.1 - 3.7e-05 23.3 0.3 3.7e-05 23.3 0.3 13.0 12 3 1 13 13 13 4 BUD22 Zip PF02535.22 CDI77637.1 - 5.1 6.2 12.6 18 4.4 12.6 1.9 1 0 0 1 1 1 0 ZIP Zinc transporter Drc1-Sld2 PF11719.8 CDI77639.1 - 0.0065 16.1 1.0 0.0065 16.1 1.0 1.7 1 1 1 2 2 2 1 DNA replication and checkpoint protein DivIVA PF05103.13 CDI77639.1 - 2 8.5 5.9 0.85 9.7 0.5 2.8 3 0 0 3 3 3 0 DivIVA protein AAA PF00004.29 CDI77641.1 - 7.3e-21 75.0 0.0 1e-20 74.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDI77641.1 - 0.00059 19.8 0.0 0.0018 18.2 0.0 1.9 1 1 1 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 CDI77641.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA+ lid domain WD40 PF00400.32 CDI77644.1 - 1.5e-07 31.9 8.1 0.016 16.1 0.8 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat OmpH PF03938.14 CDI77644.1 - 0.029 14.7 3.8 0.049 14.0 3.8 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ANAPC4_WD40 PF12894.7 CDI77644.1 - 0.045 14.0 0.1 2.7 8.4 0.2 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain FliD_N PF02465.18 CDI77644.1 - 0.35 11.6 2.8 1 10.1 2.8 1.9 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus TYW3 PF02676.14 CDI77645.1 - 1.9e-37 128.7 4.9 1.9e-37 128.7 4.9 4.0 3 1 0 3 3 3 1 Methyltransferase TYW3 Met_10 PF02475.16 CDI77645.1 - 1e-15 58.0 0.0 2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 CDI77645.1 - 0.0005 19.6 0.3 0.0018 17.8 0.3 2.0 1 0 0 1 1 1 1 Methyltransferase small domain DUF1168 PF06658.12 CDI77645.1 - 0.0062 16.4 2.2 0.0062 16.4 2.2 5.0 5 0 0 5 5 5 1 Protein of unknown function (DUF1168) Methyltransf_25 PF13649.6 CDI77645.1 - 0.12 13.1 0.9 0.69 10.7 0.9 2.4 1 0 0 1 1 1 0 Methyltransferase domain eIF-3_zeta PF05091.12 CDI77645.1 - 1.5 7.7 25.0 0.23 10.4 10.6 3.3 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_23 PF13476.6 CDI77647.1 - 9.9e-11 42.5 66.3 9.9e-11 42.5 66.3 9.9 1 1 3 4 4 4 1 AAA domain SMC_N PF02463.19 CDI77647.1 - 7.7e-10 38.6 11.6 5.3e-06 26.0 0.0 5.2 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDI77647.1 - 5.7e-09 36.2 0.0 0.00063 19.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDI77647.1 - 2.9e-07 30.5 0.0 2.9e-07 30.5 0.0 5.1 2 2 2 4 4 4 1 AAA ATPase domain ABC_tran PF00005.27 CDI77647.1 - 0.00049 20.6 0.0 0.00049 20.6 0.0 9.0 4 2 2 6 6 6 2 ABC transporter AAA_29 PF13555.6 CDI77647.1 - 0.0021 17.8 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad50_zn_hook PF04423.14 CDI77647.1 - 0.0089 15.8 0.1 0.0089 15.8 0.1 5.2 6 0 0 6 6 6 1 Rad50 zinc hook motif GTP_EFTU PF00009.27 CDI77647.1 - 0.29 10.6 0.0 0.29 10.6 0.0 5.7 3 2 0 3 3 3 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDI77647.1 - 0.43 10.5 0.0 0.43 10.5 0.0 5.5 5 1 1 7 7 7 0 RsgA GTPase Pkinase PF00069.25 CDI77648.1 - 4e-21 75.6 0.0 1.7e-19 70.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CDI77648.1 - 5.2e-10 39.1 0.0 1.1e-07 31.5 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Pkinase_Tyr PF07714.17 CDI77648.1 - 4e-08 32.9 0.0 1.6e-07 30.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI77648.1 - 0.027 13.8 0.4 0.068 12.5 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI77648.1 - 0.033 14.1 4.8 0.093 12.6 0.1 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF4775 PF16001.5 CDI77648.1 - 0.045 13.2 11.2 0.063 12.7 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) LRR_4 PF12799.7 CDI77649.1 - 1e-09 38.5 10.0 3.4e-05 24.1 1.3 4.3 2 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI77649.1 - 1.8e-08 34.0 7.8 2.6e-05 23.9 1.6 3.4 1 1 3 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 CDI77649.1 - 1.2e-06 28.2 8.2 1.3e-05 24.8 6.9 2.7 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 CDI77649.1 - 3e-05 23.7 0.3 0.25 11.5 0.1 4.2 4 0 0 4 4 4 1 Leucine Rich repeat EIF4E-T PF10477.9 CDI77649.1 - 0.0045 15.9 3.6 0.0051 15.7 3.6 1.1 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E LRR_1 PF00560.33 CDI77649.1 - 0.44 11.3 12.5 9.6 7.2 2.1 5.4 5 1 0 5 5 4 0 Leucine Rich Repeat Spt20 PF12090.8 CDI77649.1 - 1.3 8.6 20.8 1.9 8.1 20.8 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI77649.1 - 1.9 8.4 19.9 2.5 8.0 19.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5421 PF17458.2 CDI77649.1 - 1.9 7.8 10.8 2.5 7.4 10.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) FTZ PF03867.14 CDI77649.1 - 2 7.9 9.1 2.8 7.4 9.1 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DUF2722 PF10846.8 CDI77649.1 - 6.9 5.5 17.1 9.4 5.1 17.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI77649.1 - 7 5.5 31.2 9.8 5.0 31.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI77651.1 - 0.095 12.3 24.6 0.13 11.9 24.6 1.4 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CDI77651.1 - 0.26 10.0 11.3 0.27 9.9 11.3 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI77651.1 - 0.46 8.7 12.5 0.5 8.6 12.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2924 PF11149.8 CDI77651.1 - 0.48 10.8 5.2 1 9.8 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) Lin-8 PF03353.15 CDI77651.1 - 0.75 9.3 14.4 0.85 9.1 14.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SpoIIP PF07454.11 CDI77651.1 - 0.77 9.2 11.7 0.9 8.9 11.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDRGK PF09756.9 CDI77651.1 - 2.4 7.7 16.3 2.8 7.5 16.3 1.1 1 0 0 1 1 1 0 DDRGK domain Plasmodium_Vir PF05795.11 CDI77651.1 - 2.4 7.5 9.4 3.2 7.1 9.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CPSF100_C PF13299.6 CDI77651.1 - 2.4 8.3 9.2 5.1 7.3 9.2 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Pes-10 PF07149.11 CDI77651.1 - 3.2 6.7 9.6 3.6 6.5 9.6 1.1 1 0 0 1 1 1 0 Pes-10 PAT1 PF09770.9 CDI77651.1 - 4.1 5.5 15.9 4.2 5.5 15.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI77651.1 - 4.1 6.3 9.4 4.5 6.2 9.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI77651.1 - 4.8 7.2 6.3 5.6 6.9 6.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Apt1 PF10351.9 CDI77651.1 - 4.9 5.9 10.0 5.3 5.8 10.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 CDI77651.1 - 6 6.7 18.9 7 6.4 18.9 1.1 1 0 0 1 1 1 0 SPX domain GOLD_2 PF13897.6 CDI77651.1 - 6.5 7.3 5.7 9.3 6.7 5.7 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Peptidase_S64 PF08192.11 CDI77651.1 - 7.2 5.0 11.5 7.4 4.9 11.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF913 PF06025.12 CDI77651.1 - 7.3 5.5 7.7 8.7 5.2 7.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ORC_WH_C PF18137.1 CDI77651.1 - 8.6 6.4 12.4 17 5.5 12.4 1.6 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal PP2C PF00481.21 CDI77655.1 - 1.1e-30 107.2 0.7 3.6e-22 79.2 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C DUF1645 PF07816.11 CDI77655.1 - 3e-05 24.7 7.2 5.1e-05 23.9 7.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) DUF755 PF05501.11 CDI77655.1 - 0.00012 22.3 23.9 0.00019 21.7 23.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF755) EPL1 PF10513.9 CDI77655.1 - 0.00098 19.5 3.4 0.0012 19.2 3.4 1.1 1 0 0 1 1 1 1 Enhancer of polycomb-like DUF1635 PF07795.11 CDI77655.1 - 0.0021 18.0 14.1 0.003 17.4 14.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) TFIIA PF03153.13 CDI77655.1 - 0.0022 18.0 15.4 0.0028 17.7 15.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 CDI77655.1 - 0.0023 17.6 13.3 0.0035 17.0 13.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Lin-8 PF03353.15 CDI77655.1 - 0.0039 16.8 11.2 0.0048 16.5 11.2 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI77655.1 - 0.0069 15.2 5.2 0.008 15.0 5.2 1.1 1 0 0 1 1 1 1 Presenilin Centro_C10orf90 PF17730.1 CDI77655.1 - 0.011 14.5 10.8 0.014 14.2 10.8 1.1 1 0 0 1 1 1 0 Centrosomal C10orf90 MMR1 PF08505.10 CDI77655.1 - 0.029 14.7 11.8 0.042 14.1 11.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Med15 PF09606.10 CDI77655.1 - 0.037 12.7 15.3 0.047 12.4 15.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CPSF100_C PF13299.6 CDI77655.1 - 0.041 14.1 3.9 0.058 13.6 3.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Menin PF05053.13 CDI77655.1 - 0.041 12.3 3.6 0.054 11.9 3.6 1.0 1 0 0 1 1 1 0 Menin GREB1 PF15782.5 CDI77655.1 - 0.047 10.8 11.2 0.056 10.6 11.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PP2C_2 PF13672.6 CDI77655.1 - 0.057 13.0 2.0 0.85 9.2 2.0 2.1 1 1 0 1 1 1 0 Protein phosphatase 2C AF-4 PF05110.13 CDI77655.1 - 0.071 11.2 17.1 0.09 10.9 17.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein NEMP PF10225.9 CDI77655.1 - 0.079 12.6 2.0 0.11 12.2 2.0 1.2 1 0 0 1 1 1 0 NEMP family DUF4175 PF13779.6 CDI77655.1 - 0.1 10.5 11.5 0.11 10.3 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Cwf_Cwc_15 PF04889.12 CDI77655.1 - 0.12 12.1 9.4 0.16 11.7 9.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RR_TM4-6 PF06459.12 CDI77655.1 - 0.13 12.1 6.4 0.16 11.8 6.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CDI77655.1 - 0.14 11.8 24.9 0.19 11.3 24.9 1.1 1 0 0 1 1 1 0 Spt20 family MCU PF04678.13 CDI77655.1 - 0.14 12.3 2.5 0.19 11.8 2.5 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF4692 PF15763.5 CDI77655.1 - 0.17 12.3 6.5 0.25 11.8 6.5 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Macoilin PF09726.9 CDI77655.1 - 0.18 10.3 8.0 0.22 10.0 8.0 1.1 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 CDI77655.1 - 0.23 9.2 8.4 0.28 8.9 8.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Apt1 PF10351.9 CDI77655.1 - 0.3 9.9 10.0 0.36 9.6 10.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF2722 PF10846.8 CDI77655.1 - 0.34 9.8 23.6 0.48 9.3 23.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TERB2 PF15101.6 CDI77655.1 - 0.39 10.7 9.4 0.6 10.1 9.4 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PRC2_HTH_1 PF18118.1 CDI77655.1 - 0.45 11.3 8.1 0.85 10.5 8.1 1.5 1 1 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain DUF908 PF06012.12 CDI77655.1 - 0.58 9.5 11.6 0.77 9.1 11.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CLN3 PF02487.17 CDI77655.1 - 0.71 8.9 3.9 0.9 8.5 3.9 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4718 PF15842.5 CDI77655.1 - 0.97 9.2 7.3 1.5 8.6 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) ALMT PF11744.8 CDI77655.1 - 1.1 8.1 11.3 1.4 7.6 11.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 CDI77655.1 - 1.2 9.1 4.6 1.6 8.8 4.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MPM1 PF17234.2 CDI77655.1 - 1.3 9.3 12.7 1.8 8.8 12.7 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Plasmodium_Vir PF05795.11 CDI77655.1 - 1.5 8.1 8.1 2 7.8 8.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Mem_trans PF03547.18 CDI77655.1 - 1.6 7.0 6.7 2.2 6.6 6.7 1.1 1 0 0 1 1 1 0 Membrane transport protein Roughex PF06020.11 CDI77655.1 - 2.1 7.3 14.1 3 6.9 14.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein ANAPC_CDC26 PF10471.9 CDI77655.1 - 2.3 9.1 25.9 4.6 8.1 25.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 CobT PF06213.12 CDI77655.1 - 2.3 7.5 15.8 3.4 7.0 15.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4407 PF14362.6 CDI77655.1 - 2.6 7.3 9.8 3.6 6.9 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDK2AP PF09806.9 CDI77655.1 - 2.8 7.9 13.4 4.1 7.4 13.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Connexin PF00029.19 CDI77655.1 - 3.1 7.5 4.2 4.3 7.0 4.2 1.2 1 0 0 1 1 1 0 Connexin Ndc1_Nup PF09531.10 CDI77655.1 - 3.2 6.3 11.7 4.2 5.9 11.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Allexi_40kDa PF05549.11 CDI77655.1 - 3.6 7.0 7.8 5.2 6.5 7.8 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein SLC12 PF03522.15 CDI77655.1 - 4 6.4 11.5 5.1 6.0 11.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SWIB PF02201.18 CDI77656.1 - 3.9e-16 58.7 0.0 7.1e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain SR-25 PF10500.9 CDI77657.1 - 0.094 12.3 17.8 0.16 11.6 17.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDI77657.1 - 4.3 7.7 16.2 30 5.0 12.0 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain ORC6 PF05460.13 CDI77657.1 - 7.2 5.8 10.2 10 5.3 10.2 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) RskA PF10099.9 CDI77658.1 - 0.001 19.4 0.9 0.001 19.4 0.9 6.5 2 2 1 4 4 4 2 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI77658.1 - 0.019 15.4 7.5 0.019 15.4 7.5 12.8 10 2 0 10 10 10 0 Potassium channel Kv1.4 tandem inactivation domain Spt20 PF12090.8 CDI77660.1 - 4e-05 23.3 22.0 4e-05 23.3 22.0 2.0 2 0 0 2 2 2 1 Spt20 family EPL1 PF10513.9 CDI77660.1 - 0.0048 17.3 12.4 0.0094 16.3 12.1 1.7 2 0 0 2 2 2 1 Enhancer of polycomb-like PAT1 PF09770.9 CDI77660.1 - 0.005 15.2 15.9 0.0063 14.9 15.9 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 eIF-3_zeta PF05091.12 CDI77660.1 - 0.0076 15.3 13.4 0.01 14.9 13.4 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hid1 PF12722.7 CDI77660.1 - 0.023 12.9 9.9 0.028 12.6 9.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GTA_holin_3TM PF11351.8 CDI77660.1 - 0.034 14.7 4.6 0.034 14.7 4.6 2.3 3 0 0 3 3 1 0 Holin of 3TMs, for gene-transfer release FAM76 PF16046.5 CDI77660.1 - 0.045 13.1 11.4 0.071 12.5 11.4 1.3 1 0 0 1 1 1 0 FAM76 protein Suf PF05843.14 CDI77660.1 - 0.057 13.4 8.7 0.12 12.4 8.7 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI77660.1 - 0.059 12.1 11.5 0.079 11.7 11.5 1.2 1 0 0 1 1 1 0 Presenilin MMR1 PF08505.10 CDI77660.1 - 0.062 13.6 11.9 0.12 12.6 11.9 1.6 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Macoilin PF09726.9 CDI77660.1 - 0.29 9.7 17.9 0.49 8.9 17.9 1.3 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 CDI77660.1 - 0.51 9.3 9.6 0.71 8.8 9.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CCDC53 PF10152.9 CDI77660.1 - 0.55 10.6 15.1 0.7 10.3 8.6 2.6 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TERB2 PF15101.6 CDI77660.1 - 0.55 10.3 14.5 0.25 11.4 11.9 1.7 2 0 0 2 2 2 0 Telomere-associated protein TERB2 MDM10 PF12519.8 CDI77660.1 - 0.64 8.8 7.8 0.87 8.4 7.8 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Otopetrin PF03189.13 CDI77660.1 - 0.66 8.7 3.2 0.85 8.4 3.2 1.1 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 CDI77660.1 - 0.85 8.8 14.4 1.4 8.0 14.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI77660.1 - 0.99 7.4 10.3 1.3 7.0 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RR_TM4-6 PF06459.12 CDI77660.1 - 1.9 8.2 11.3 3.1 7.6 11.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI77660.1 - 2.9 6.8 6.6 4.3 6.3 6.6 1.2 1 0 0 1 1 1 0 CLN3 protein SelP_N PF04592.14 CDI77660.1 - 4.2 6.7 26.9 7.6 5.9 26.9 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1764 PF08576.10 CDI77660.1 - 4.3 8.3 10.0 11 6.9 10.0 1.7 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Neur_chan_memb PF02932.16 CDI77660.1 - 4.5 7.3 11.2 9.4 6.2 11.2 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CPSF100_C PF13299.6 CDI77660.1 - 5.9 7.1 9.6 13 6.0 9.6 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 CDI77660.1 - 6.3 4.6 14.8 8.8 4.1 14.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI77660.1 - 9 6.0 11.3 13 5.4 11.3 1.2 1 0 0 1 1 1 0 Connexin Ribosomal_S8e PF01201.22 CDI77661.1 - 5.2e-53 178.9 0.2 6.2e-53 178.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e SUKH-4 PF14435.6 CDI77662.1 - 0.05 13.6 0.2 0.082 13.0 0.2 1.3 1 0 0 1 1 1 0 SUKH-4 immunity protein eIF_4EBP PF05456.11 CDI77662.1 - 0.052 13.5 0.6 0.12 12.4 0.6 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Ferlin_C PF16165.5 CDI77662.1 - 0.054 13.4 0.3 0.082 12.9 0.3 1.2 1 0 0 1 1 1 0 Ferlin C-terminus Med3 PF11593.8 CDI77662.1 - 0.076 12.2 4.3 0.12 11.5 4.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4834 PF16118.5 CDI77662.1 - 0.47 11.5 4.4 0.43 11.6 2.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Band_7 PF01145.25 CDI77662.1 - 1 9.4 8.6 1.4 8.9 8.6 1.2 1 0 0 1 1 1 0 SPFH domain / Band 7 family SUIM_assoc PF16619.5 CDI77662.1 - 1.7 8.8 17.8 0.047 13.7 9.6 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI77662.1 - 3.8 7.1 15.6 0.48 10.0 11.6 1.4 2 0 0 2 2 2 0 Spt20 family DUF3123 PF11321.8 CDI77664.1 - 0.0032 18.1 10.5 0.0063 17.2 0.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3123) Ribosomal_60s PF00428.19 CDI77664.1 - 0.0064 17.0 13.8 0.0064 17.0 13.8 3.2 3 1 0 3 3 3 1 60s Acidic ribosomal protein SR-25 PF10500.9 CDI77664.1 - 0.013 15.1 15.1 0.013 15.1 15.1 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2721 PF11026.8 CDI77664.1 - 0.071 13.0 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) GCOM2 PF15328.6 CDI77664.1 - 0.17 12.3 11.1 0.18 12.2 10.6 1.3 1 1 0 1 1 1 0 Putative GRINL1B complex locus protein 2 BUD22 PF09073.10 CDI77664.1 - 0.24 10.7 10.3 0.29 10.4 10.3 1.1 1 0 0 1 1 1 0 BUD22 DUF3446 PF11928.8 CDI77664.1 - 0.31 11.4 15.6 1.4 9.2 12.0 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain GREB1 PF15782.5 CDI77664.1 - 0.55 7.3 6.4 0.59 7.2 6.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer IMUP PF15761.5 CDI77664.1 - 1.4 9.6 16.6 0.34 11.6 11.8 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF3399 PF11879.8 CDI77664.1 - 9.2 6.7 13.8 19 5.7 13.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3399) DUF3484 PF11983.8 CDI77665.1 - 9 7.5 0.0 9 7.5 0.0 9.2 2 1 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch DNA_pol_A_exo1 PF01612.20 CDI77666.1 - 6.8e-09 35.7 0.0 1.1e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease DUF4216 PF13952.6 CDI77666.1 - 0.12 12.8 0.0 6.1 7.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4216) NdhL PF10716.9 CDI77667.1 - 0.014 15.4 2.1 0.024 14.6 2.1 1.3 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit Dehydrin PF00257.19 CDI77667.1 - 0.068 13.7 3.2 0.089 13.3 3.2 1.1 1 0 0 1 1 1 0 Dehydrin PrpF PF04303.13 CDI77667.1 - 0.072 12.0 0.7 0.1 11.6 0.7 1.1 1 0 0 1 1 1 0 PrpF protein FSA_C PF10479.9 CDI77667.1 - 0.45 8.6 6.0 0.6 8.2 6.0 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF2057 PF09829.9 CDI77667.1 - 1.3 9.1 4.9 1.9 8.6 4.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Peptidase_M17 PF00883.21 CDI77668.1 - 9.8e-114 379.8 4.8 9.8e-114 379.8 4.8 2.4 2 0 0 2 2 2 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDI77668.1 - 2e-08 34.2 0.0 2e-08 34.2 0.0 4.6 3 1 1 4 4 4 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_C48 PF02902.19 CDI77669.1 - 1.7e-27 96.7 0.0 5.1e-27 95.1 0.0 1.8 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain NAM-associated PF14303.6 CDI77669.1 - 4.9e-06 27.4 0.0 4.9e-06 27.4 0.0 8.9 4 2 3 7 7 7 1 No apical meristem-associated C-terminal domain DUF86 PF01934.17 CDI77670.1 - 0.069 13.0 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF86 JAKMIP_CC3 PF16034.5 CDI77671.1 - 0.094 12.7 0.2 0.12 12.3 0.2 1.2 1 0 0 1 1 1 0 JAKMIP CC3 domain IMUP PF15761.5 CDI77672.1 - 0.0072 17.0 3.9 0.0072 17.0 3.9 6.9 5 2 2 7 7 7 2 Immortalisation up-regulated protein AKAP95 PF04988.12 CDI77672.1 - 0.22 11.8 1.8 6.1 7.0 0.1 2.4 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) DUF4179 PF13786.6 CDI77672.1 - 0.32 11.5 14.1 1.9 9.0 3.0 4.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4179) GDA1_CD39 PF01150.17 CDI77673.1 - 5.1e-29 101.2 0.1 4.9e-21 74.9 0.1 2.7 3 0 0 3 3 3 2 GDA1/CD39 (nucleoside phosphatase) family PIN_9 PF18477.1 CDI77673.1 - 5.2 7.4 5.4 1.7 9.0 0.6 2.3 2 0 0 2 2 2 0 PIN like domain Tir_receptor_C PF07489.11 CDI77674.1 - 0.0015 18.6 2.9 0.0026 17.8 2.9 1.3 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) C-terminus STI1 PF17830.1 CDI77674.1 - 0.013 15.4 0.3 0.028 14.3 0.3 1.6 1 0 0 1 1 1 0 STI1 domain SR-25 PF10500.9 CDI77674.1 - 0.19 11.3 11.6 0.28 10.7 11.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 CDI77674.1 - 3.9 5.4 9.8 5.2 5.0 9.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Med15 PF09606.10 CDI77675.1 - 0.63 8.7 20.8 0.63 8.7 20.8 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Androgen_recep PF02166.16 CDI77675.1 - 6 5.6 15.6 5.5 5.7 15.6 1.2 1 0 0 1 1 1 0 Androgen receptor TFIIA PF03153.13 CDI77675.1 - 7.1 6.5 20.5 7.2 6.5 20.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ABC_ATPase PF09818.9 CDI77676.1 - 9.7e-178 591.5 0.0 1.3e-177 591.1 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 CDI77676.1 - 0.00043 20.8 0.0 0.00067 20.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI77676.1 - 0.07 12.9 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Exo_endo_phos PF03372.23 CDI77677.1 - 1.3e-11 44.5 0.0 2.3e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TFIIS_C PF01096.18 CDI77677.1 - 8.3e-06 25.6 3.7 1.8e-05 24.5 0.1 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 CDI77677.1 - 0.042 14.0 4.2 2.6 8.3 0.0 3.6 3 0 0 3 3 3 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.13 CDI77677.1 - 3.5 7.4 7.8 0.58 9.9 0.1 3.2 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_2 PF13240.6 CDI77677.1 - 3.8 7.4 6.3 51 3.8 0.2 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Kelch_3 PF13415.6 CDI77678.1 - 7.5e-25 86.7 9.9 1.9e-09 37.6 0.5 5.3 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI77678.1 - 8.5e-23 79.9 3.3 3.5e-05 23.7 0.0 4.8 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 CDI77678.1 - 1.1e-22 79.7 7.2 7.7e-06 25.8 0.7 4.7 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI77678.1 - 7.6e-14 51.1 16.5 0.00095 19.1 1.9 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 CDI77678.1 - 3.4e-12 45.8 15.2 0.0021 17.6 0.2 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 CDI77678.1 - 4.2e-12 45.9 15.2 6.6e-06 26.2 0.6 4.8 2 1 3 5 5 5 3 Kelch motif Yuri_gagarin PF15934.5 CDI77678.1 - 0.0027 17.6 0.3 0.0037 17.1 0.3 1.1 1 0 0 1 1 1 1 Yuri gagarin DUF4678 PF15727.5 CDI77678.1 - 0.0057 16.0 0.1 0.0083 15.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4678) DUF241 PF03087.14 CDI77678.1 - 0.031 14.1 0.0 0.043 13.6 0.0 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function Prefoldin_2 PF01920.20 CDI77678.1 - 0.051 13.5 0.1 0.098 12.6 0.1 1.4 1 0 0 1 1 1 0 Prefoldin subunit DUF601 PF04642.12 CDI77678.1 - 0.092 12.2 0.5 0.13 11.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 adh_short PF00106.25 CDI77679.1 - 4.1e-10 39.4 0.0 1e-09 38.1 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDI77679.1 - 5.3e-08 32.7 0.0 2e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDI77679.1 - 0.00029 20.8 0.1 0.0019 18.2 0.0 2.0 2 0 0 2 2 2 1 KR domain TTc_toxin_rep PF18807.1 CDI77679.1 - 0.003 17.3 0.0 0.019 14.7 0.0 2.3 3 0 0 3 3 3 1 Tripartite Tc toxins repeat ORC2 PF04084.14 CDI77680.1 - 5.8e-27 94.5 0.0 8.3e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 TraT PF05818.12 CDI77681.1 - 4.6 6.9 9.8 0.06 13.0 1.1 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein TMA7 PF09072.10 CDI77682.1 - 1.8e-07 31.9 18.5 2.8e-07 31.3 18.5 1.3 1 1 0 1 1 1 1 Translation machinery associated TMA7 C2 PF00168.30 CDI77683.1 - 1.7e-19 70.0 0.0 1e-06 29.0 0.0 4.8 4 0 0 4 4 4 4 C2 domain Ferlin_C PF16165.5 CDI77683.1 - 0.04 13.9 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Ferlin C-terminus SF3b1 PF08920.10 CDI77684.1 - 2.6e-26 92.4 19.7 6.3e-24 84.7 4.9 4.1 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT PF02985.22 CDI77684.1 - 6.9e-09 35.2 6.7 1.3 9.5 0.1 8.2 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.6 CDI77684.1 - 7.6e-06 26.3 8.5 0.29 11.7 0.0 6.7 8 1 1 9 9 8 2 HEAT-like repeat UME PF08064.13 CDI77684.1 - 1.9e-05 24.5 0.7 10 6.1 0.0 5.3 5 1 0 5 5 5 2 UME (NUC010) domain Adaptin_N PF01602.20 CDI77684.1 - 0.00012 20.8 0.4 0.2 10.1 0.0 3.7 3 1 1 4 4 4 2 Adaptin N terminal region HEAT_2 PF13646.6 CDI77684.1 - 0.00034 20.9 19.1 0.19 12.1 0.1 7.7 6 2 4 10 10 10 3 HEAT repeats NUC173 PF08161.12 CDI77684.1 - 0.01 15.5 0.0 3.7 7.1 0.0 4.1 3 1 0 4 4 4 0 NUC173 domain Bep_C_terminal PF17841.1 CDI77684.1 - 0.023 14.9 2.1 0.073 13.3 2.1 1.8 1 0 0 1 1 1 0 BID domain of Bartonella effector protein (Bep) CLASP_N PF12348.8 CDI77684.1 - 0.025 14.2 0.1 1.1 8.7 0.0 2.6 2 0 0 2 2 2 0 CLASP N terminal Arm PF00514.23 CDI77684.1 - 0.072 13.2 3.3 72 3.6 0.0 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat PsbH PF00737.20 CDI77684.1 - 6.3 6.6 6.9 7.3 6.4 0.6 3.0 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein Myb_DNA-binding PF00249.31 CDI77685.1 - 2.7e-08 33.8 3.4 0.0067 16.6 0.1 4.5 4 0 0 4 4 4 3 Myb-like DNA-binding domain ECM1 PF05782.11 CDI77686.1 - 0.34 9.8 2.0 0.47 9.3 2.0 1.2 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) CDC45 PF02724.14 CDI77686.1 - 0.77 8.0 6.0 0.94 7.7 6.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Med3 PF11593.8 CDI77686.1 - 0.9 8.7 8.6 1.1 8.4 8.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal NPR3 PF03666.13 CDI77687.1 - 0.28 9.9 11.1 0.38 9.5 11.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 CDI77687.1 - 1.1 8.0 24.8 1.5 7.6 24.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Zip PF02535.22 CDI77687.1 - 2.1 7.5 8.0 3 7.0 8.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI77687.1 - 8.2 5.1 14.3 15 4.3 14.3 1.3 1 0 0 1 1 1 0 Presenilin SOG2 PF10428.9 CDI77689.1 - 0.23 10.6 15.4 0.29 10.3 15.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3464 PF11947.8 CDI77689.1 - 0.34 10.7 3.8 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 AF-4 PF05110.13 CDI77690.1 - 0.86 7.6 9.3 1.1 7.3 9.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IMUP PF15761.5 CDI77690.1 - 1.5 9.5 15.7 3.6 8.3 15.7 1.7 1 1 0 1 1 1 0 Immortalisation up-regulated protein TRAPP PF04051.16 CDI77691.1 - 2.3e-13 50.1 0.0 3.8e-12 46.2 0.0 2.0 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4614 PF15391.6 CDI77691.1 - 0.032 14.2 15.2 0.04 13.9 15.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 CDI77691.1 - 0.032 13.1 11.0 0.031 13.2 11.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF913 PF06025.12 CDI77691.1 - 0.035 13.1 4.9 0.053 12.5 4.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Macoilin PF09726.9 CDI77691.1 - 0.13 10.7 17.7 0.14 10.7 17.7 1.0 1 0 0 1 1 1 0 Macoilin family NPR3 PF03666.13 CDI77691.1 - 0.19 10.5 7.2 0.2 10.4 7.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SPX PF03105.19 CDI77691.1 - 0.72 9.7 13.4 0.79 9.6 13.4 1.1 1 0 0 1 1 1 0 SPX domain DUF3827 PF12877.7 CDI77691.1 - 0.98 7.7 12.5 1.1 7.6 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) NAM-associated PF14303.6 CDI77691.1 - 1.1 10.0 9.3 1.3 9.7 9.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Neur_chan_memb PF02932.16 CDI77691.1 - 1.4 9.0 4.6 1.7 8.6 4.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Miga PF10265.9 CDI77691.1 - 2.5 7.0 10.4 2.7 6.8 10.4 1.1 1 0 0 1 1 1 0 Mitoguardin Zip PF02535.22 CDI77691.1 - 2.7 7.1 5.0 3.1 6.9 5.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI77691.1 - 3.7 6.2 9.0 4.6 5.9 9.0 1.1 1 0 0 1 1 1 0 Presenilin Sec3_C PF09763.9 CDI77691.1 - 4.8 5.4 8.6 6 5.1 8.6 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 FAM117 PF15388.6 CDI77691.1 - 6.7 6.0 17.1 9.2 5.6 17.1 1.1 1 0 0 1 1 1 0 Protein Family FAM117 Tmemb_cc2 PF10267.9 CDI77691.1 - 9.7 5.2 9.1 11 5.1 9.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RskA PF10099.9 CDI77692.1 - 0.0012 19.2 2.2 0.0012 19.2 2.2 3.2 2 1 1 3 3 3 2 Anti-sigma-K factor rskA TFIIF_alpha PF05793.12 CDI77692.1 - 0.031 12.9 38.7 0.042 12.4 38.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 CDI77692.1 - 0.15 11.5 33.0 0.24 10.8 33.0 1.3 1 0 0 1 1 1 0 SDA1 SPX PF03105.19 CDI77692.1 - 0.38 10.6 36.4 0.8 9.6 36.4 1.5 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 CDI77692.1 - 1.5 5.8 33.9 1.9 5.5 33.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 CDI77692.1 - 2.8 7.5 31.2 4.7 6.7 31.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Asp-B-Hydro_N PF05279.11 CDI77692.1 - 8.3 6.4 23.8 12 5.8 23.8 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4746 PF15928.5 CDI77692.1 - 9.6 5.5 20.1 15 4.9 20.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SPRY PF00622.28 CDI77694.1 - 3.3e-05 24.0 0.0 6.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 SPRY domain DUF5343 PF17278.2 CDI77694.1 - 0.12 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5343) EMP24_GP25L PF01105.24 CDI77695.1 - 3.9e-30 105.1 0.0 4.8e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 CDI77698.1 - 0.14 10.3 0.9 0.25 9.5 0.9 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA SHE3 PF17078.5 CDI77698.1 - 0.14 11.8 0.1 0.26 11.0 0.1 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 SR-25 PF10500.9 CDI77699.1 - 0.0047 16.6 7.1 0.0047 16.6 7.1 3.0 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein 7tm_7 PF08395.12 CDI77699.1 - 0.69 9.1 0.0 0.69 9.1 0.0 2.4 2 1 1 3 3 3 0 7tm Chemosensory receptor WBP-1 PF11669.8 CDI77699.1 - 1.1 10.0 4.9 2.6 8.7 1.0 2.6 2 0 0 2 2 2 0 WW domain-binding protein 1 SPX PF03105.19 CDI77699.1 - 1.2 8.9 10.3 1.3 8.8 0.2 2.3 2 0 0 2 2 2 0 SPX domain RcpC PF16976.5 CDI77699.1 - 2 8.5 10.9 26 4.9 1.6 3.7 3 0 0 3 3 3 0 Flp pilus assembly protein RcpC/CpaB DEAD PF00270.29 CDI77700.1 - 1.7e-34 119.1 0.0 6e-34 117.3 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI77700.1 - 1.4e-25 89.8 0.0 1.2e-24 86.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI77700.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDI77700.1 - 0.057 12.6 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase GUCT PF08152.12 CDI77700.1 - 0.13 12.5 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 GUCT (NUC152) domain Hist_deacetyl PF00850.19 CDI77701.1 - 2.2e-76 257.3 0.0 5e-76 256.1 0.0 1.6 1 1 0 1 1 1 1 Histone deacetylase domain DnaJ PF00226.31 CDI77702.1 - 4.7e-26 90.7 1.2 9.3e-26 89.7 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain Thiolase_N PF00108.23 CDI77704.1 - 2.3e-68 230.4 0.4 4.6e-68 229.4 0.1 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDI77704.1 - 7.1e-50 167.8 0.3 7.1e-50 167.8 0.3 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDI77704.1 - 3.1e-06 26.9 1.6 7.7e-06 25.7 1.5 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 CDI77704.1 - 0.088 13.0 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ZapB PF06005.12 CDI77707.1 - 0.0065 16.9 0.1 0.0065 16.9 0.1 3.6 2 1 0 2 2 2 1 Cell division protein ZapB DcuC PF03606.15 CDI77709.1 - 0.00092 17.8 0.6 0.0019 16.7 0.6 1.5 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier DnaJ PF00226.31 CDI77709.1 - 0.0032 17.6 0.1 0.0078 16.3 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain RskA PF10099.9 CDI77709.1 - 0.41 10.9 54.7 0.036 14.4 21.4 4.8 1 1 3 4 4 4 0 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI77710.1 - 1.4e-06 28.1 4.4 1.4e-06 28.1 4.4 4.4 4 2 1 5 5 5 2 Nuclear RNA-splicing-associated protein Dehydrin PF00257.19 CDI77710.1 - 0.68 10.5 0.0 0.68 10.5 0.0 5.0 5 1 0 5 5 5 0 Dehydrin DUF4539 PF15072.6 CDI77711.1 - 1.8e-06 27.9 0.1 5.6e-06 26.3 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4539) DUF2722 PF10846.8 CDI77711.1 - 0.0029 16.6 8.8 0.0029 16.6 8.8 5.0 2 1 3 5 5 5 1 Protein of unknown function (DUF2722) Rib_5-P_isom_A PF06026.14 CDI77712.1 - 1.7e-48 164.5 0.1 2.3e-24 85.9 0.0 3.9 1 1 1 2 2 2 2 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) NHL PF01436.21 CDI77712.1 - 0.00064 19.6 0.5 3.7 7.8 0.0 3.4 3 0 0 3 3 3 2 NHL repeat DUF4766 PF15973.5 CDI77712.1 - 0.0097 16.5 0.1 6.8 7.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4766) Rhabdo_M1 PF03342.13 CDI77712.1 - 0.086 12.2 0.0 14 5.0 0.0 2.1 2 0 0 2 2 2 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) IFRD PF05004.13 CDI77712.1 - 0.088 11.9 0.0 10 5.1 0.0 2.1 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TetR_C_6 PF13977.6 CDI77712.1 - 0.12 12.6 0.3 23 5.2 0.0 2.3 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal Dynein_attach_N PF15867.5 CDI77713.1 - 5.4e-12 45.5 0.2 1.1e-11 44.5 0.2 1.4 1 0 0 1 1 1 1 Dynein attachment factor N-terminus RPAP3_C PF13877.6 CDI77713.1 - 2.6e-05 24.7 0.0 0.00016 22.1 0.0 2.2 3 0 0 3 3 3 1 Potential Monad-binding region of RPAP3 Macoilin PF09726.9 CDI77713.1 - 0.021 13.4 20.7 0.071 11.7 0.6 2.4 2 0 0 2 2 2 0 Macoilin family SOBP PF15279.6 CDI77713.1 - 0.31 11.6 12.3 0.64 10.6 12.3 1.6 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4614 PF15391.6 CDI77713.1 - 2.4 8.2 26.4 4.5 7.2 13.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) AF-4 PF05110.13 CDI77713.1 - 2.6 6.0 42.7 0.39 8.8 12.2 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein tRNA-synt_2 PF00152.20 CDI77715.1 - 3.1e-50 171.0 0.0 4.9e-34 117.8 0.0 3.2 1 1 1 2 2 2 2 tRNA synthetases class II (D, K and N) DUF2722 PF10846.8 CDI77715.1 - 1e-08 34.6 22.1 0.0033 16.5 0.0 4.3 3 2 0 3 3 3 1 Protein of unknown function (DUF2722) AAA_23 PF13476.6 CDI77715.1 - 0.0042 17.6 5.2 0.046 14.2 0.6 2.5 2 0 0 2 2 2 1 AAA domain Spt20 PF12090.8 CDI77715.1 - 0.0091 15.6 1.6 0.0091 15.6 1.6 4.1 3 1 0 3 3 3 1 Spt20 family tRNA_anti-codon PF01336.25 CDI77715.1 - 0.012 15.5 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RNase_H2_suC PF08615.11 CDI77715.1 - 0.041 14.0 3.8 1.7 8.8 0.0 2.7 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) EIIBC-GUT_N PF03612.14 CDI77715.1 - 2.6 7.7 11.5 9.6 5.9 6.5 2.7 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus eIF-3_zeta PF05091.12 CDI77715.1 - 8.1 5.3 16.0 2 7.3 9.2 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) G0-G1_switch_2 PF15103.6 CDI77715.1 - 9.7 6.7 9.0 15 6.1 3.2 2.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 Aminotran_5 PF00266.19 CDI77716.1 - 7.5e-51 173.2 1.9 1.1e-19 70.7 0.1 3.3 1 1 2 3 3 3 3 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CDI77716.1 - 9e-05 21.9 0.1 9e-05 21.9 0.1 3.2 4 0 0 4 4 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 CDI77716.1 - 0.0017 17.1 0.1 0.004 15.9 0.1 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain FAM222A PF15258.6 CDI77716.1 - 0.11 11.6 26.5 0.012 14.8 15.4 2.3 2 0 0 2 2 2 0 Protein family of FAM222A Med15 PF09606.10 CDI77716.1 - 0.13 10.9 38.4 0.071 11.8 26.5 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal HCO3_cotransp PF00955.21 CDI77716.1 - 0.16 10.8 0.2 0.24 10.2 0.2 1.2 1 0 0 1 1 1 0 HCO3- transporter family Gti1_Pac2 PF09729.9 CDI77716.1 - 0.17 12.0 8.2 0.2 11.7 5.3 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family EPL1 PF10513.9 CDI77716.1 - 0.2 12.0 11.8 1.2 9.5 9.4 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Presenilin PF01080.17 CDI77716.1 - 0.29 9.9 16.0 0.068 11.9 10.8 2.0 2 0 0 2 2 2 0 Presenilin DUF2052 PF09747.9 CDI77716.1 - 0.32 11.1 17.5 1.2 9.2 14.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Dicty_REP PF05086.12 CDI77716.1 - 0.33 8.9 2.4 0.44 8.5 2.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SpoIIP PF07454.11 CDI77716.1 - 0.34 10.3 12.6 0.013 15.0 5.3 1.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CDI77716.1 - 0.43 9.5 6.3 0.36 9.8 4.5 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Radial_spoke_3 PF06098.11 CDI77716.1 - 0.59 9.4 24.5 0.045 13.0 15.8 2.3 2 0 0 2 2 2 0 Radial spoke protein 3 CPSF100_C PF13299.6 CDI77716.1 - 0.82 9.8 12.5 0.13 12.4 5.8 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Band_3_cyto PF07565.13 CDI77716.1 - 1.1 9.1 14.1 8.3 6.1 12.1 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Ndc1_Nup PF09531.10 CDI77716.1 - 2 7.0 9.1 0.29 9.8 3.5 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup eIF-3_zeta PF05091.12 CDI77716.1 - 2 7.3 23.0 0.13 11.2 14.8 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pex14_N PF04695.13 CDI77716.1 - 2.3 8.8 31.3 0.19 12.4 18.3 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.9 CDI77716.1 - 2.4 6.3 29.4 1.5 7.0 22.5 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 UPF0564 PF10595.9 CDI77716.1 - 2.7 7.0 30.3 0.033 13.2 16.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 SID-1_RNA_chan PF13965.6 CDI77716.1 - 3.3 6.0 4.7 5.4 5.3 4.7 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PIEZO PF15917.5 CDI77716.1 - 5.7 6.4 26.0 19 4.6 20.6 2.2 2 0 0 2 2 2 0 Piezo CSG2 PF16965.5 CDI77716.1 - 8 5.3 6.4 15 4.4 6.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 CDI77716.1 - 8.8 6.1 17.7 1.5 8.6 12.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF702 PF05142.12 CDI77716.1 - 9.9 6.6 24.9 7 7.1 15.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF2722 PF10846.8 CDI77717.1 - 0.0012 17.9 0.7 0.0012 17.9 0.7 12.3 5 3 7 12 12 12 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI77717.1 - 0.0013 19.1 0.1 0.0013 19.1 0.1 9.8 2 2 3 6 6 6 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI77717.1 - 0.0025 17.8 1.0 0.0025 17.8 1.0 19.5 10 6 4 14 14 14 1 Unstructured region C-term to UIM in Ataxin3 MSP1_C PF07462.11 CDI77718.1 - 0.95 8.1 5.7 1 8.0 5.7 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus TAF6_C PF07571.13 CDI77723.1 - 3.1e-06 27.4 0.2 3.1e-06 27.4 0.2 2.7 3 0 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain TFIIA PF03153.13 CDI77723.1 - 0.004 17.2 64.5 0.075 13.0 29.6 3.2 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit TAF PF02969.17 CDI77723.1 - 0.057 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) NBP1 PF08537.10 CDI77723.1 - 1.4 8.2 23.5 0.66 9.3 5.4 3.2 3 0 0 3 3 3 0 Fungal Nap binding protein NBP1 Secretin_N_2 PF07655.13 CDI77723.1 - 1.4 9.5 13.6 0.32 11.6 0.6 2.8 3 0 0 3 3 3 0 Secretin N-terminal domain DUF572 PF04502.13 CDI77723.1 - 2.7 7.5 29.3 0.79 9.3 6.3 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF572) Holin_2-3 PF13272.6 CDI77724.1 - 0.11 12.8 0.2 0.11 12.8 0.2 2.4 3 1 0 3 3 3 0 Putative 2/3 transmembrane domain holin TFB6 PF17110.5 CDI77724.1 - 0.33 10.7 5.2 0.79 9.5 0.7 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH SID-1_RNA_chan PF13965.6 CDI77724.1 - 0.34 9.3 3.6 0.48 8.8 3.3 1.4 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 PmbA_TldD PF01523.16 CDI77724.1 - 3.4 7.5 6.8 4.7 7.0 6.8 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase Suf PF05843.14 CDI77724.1 - 6.9 6.6 26.6 1.4 8.8 10.3 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Sin_N PF04801.13 CDI77725.1 - 5e-06 26.0 16.6 5e-06 26.0 16.6 4.6 2 2 3 5 5 5 1 Sin-like protein conserved region DUF2722 PF10846.8 CDI77725.1 - 0.0043 16.1 4.1 0.0043 16.1 4.1 8.5 6 3 1 7 7 7 1 Protein of unknown function (DUF2722) Tau95_N PF17682.1 CDI77725.1 - 0.035 14.3 0.8 0.035 14.3 0.8 4.5 5 1 0 5 5 5 0 Tau95 Triple barrel domain O-antigen_lig PF13425.6 CDI77725.1 - 3.2 6.5 5.5 4.3 6.0 3.5 2.0 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF3458_C PF17432.2 CDI77726.1 - 4.5e-33 115.0 0.2 5.1e-33 114.8 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats TFIIA PF03153.13 CDI77727.1 - 2.8e-07 30.9 40.5 2.8e-07 30.9 40.5 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI77727.1 - 8.8e-06 25.5 8.7 9.9e-06 25.3 8.7 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit Peptidase_M1_N PF17900.1 CDI77727.1 - 4.2e-05 23.8 19.5 0.025 14.8 19.5 2.5 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Velvet PF11754.8 CDI77727.1 - 8.4e-05 22.6 20.9 0.00087 19.3 13.1 2.3 2 0 0 2 2 2 2 Velvet factor TCP PF03634.13 CDI77727.1 - 0.00018 22.1 14.4 0.00018 22.1 14.4 2.4 2 0 0 2 2 2 1 TCP family transcription factor SID-1_RNA_chan PF13965.6 CDI77727.1 - 0.00099 17.6 5.8 0.00099 17.6 5.8 1.6 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 CRT10 PF08728.10 CDI77727.1 - 0.001 17.3 7.6 0.0014 16.9 7.6 1.3 1 0 0 1 1 1 1 CRT10 SPX PF03105.19 CDI77727.1 - 0.0013 18.8 28.0 0.0026 17.8 28.0 1.4 1 0 0 1 1 1 1 SPX domain RskA PF10099.9 CDI77727.1 - 0.0035 17.6 21.0 6.7 7.0 21.0 2.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Peptidase_M1 PF01433.20 CDI77727.1 - 0.014 15.0 0.0 0.014 15.0 0.0 2.4 2 0 0 2 2 1 0 Peptidase family M1 domain Spore_coat_CotO PF14153.6 CDI77727.1 - 0.046 13.6 39.5 8.3 6.3 0.0 2.2 2 0 0 2 2 2 0 Spore coat protein CotO PAT1 PF09770.9 CDI77727.1 - 0.073 11.3 42.6 0.1 10.9 42.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Endostatin PF06482.11 CDI77727.1 - 0.1 12.1 23.9 0.034 13.6 19.5 2.0 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 CDI77727.1 - 0.1 11.6 29.8 0.19 10.7 29.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 CDI77727.1 - 0.17 10.9 16.5 0.059 12.4 13.6 1.6 2 0 0 2 2 2 0 Tumour-associated protein Otopetrin PF03189.13 CDI77727.1 - 0.31 9.8 13.7 0.57 8.9 13.7 1.4 1 0 0 1 1 1 0 Otopetrin Apt1 PF10351.9 CDI77727.1 - 0.32 9.8 32.4 0.26 10.1 15.5 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain MCM_bind PF09739.9 CDI77727.1 - 0.34 9.3 26.7 0.58 8.5 26.7 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF913 PF06025.12 CDI77727.1 - 0.38 9.7 19.1 0.37 9.7 13.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Ureide_permease PF07168.11 CDI77727.1 - 0.41 9.3 9.3 1.1 8.0 9.3 1.6 1 0 0 1 1 1 0 Ureide permease Tim54 PF11711.8 CDI77727.1 - 0.43 9.3 23.3 0.84 8.4 23.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 UPF0565 PF10561.9 CDI77727.1 - 0.59 9.3 12.8 1 8.5 12.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Presenilin PF01080.17 CDI77727.1 - 0.76 8.5 39.9 0.024 13.4 31.3 2.1 2 0 0 2 2 2 0 Presenilin GAGA_bind PF06217.12 CDI77727.1 - 1.1 9.5 24.2 1.7 8.9 24.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4638 PF15472.6 CDI77727.1 - 2.5 7.7 26.0 4.8 6.8 26.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Pkinase_fungal PF17667.1 CDI77727.1 - 4 6.1 19.1 7.1 5.3 16.3 2.0 2 0 0 2 2 2 0 Fungal protein kinase DUF4746 PF15928.5 CDI77727.1 - 4.3 6.7 22.4 7.5 5.9 22.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF572 PF04502.13 CDI77727.1 - 4.6 6.8 33.0 0.011 15.3 20.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF2052 PF09747.9 CDI77727.1 - 5.7 7.0 31.0 9.8 6.2 31.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LicD PF04991.13 CDI77727.1 - 6.3 6.9 14.4 10 6.2 14.4 1.2 1 0 0 1 1 1 0 LicD family RR_TM4-6 PF06459.12 CDI77727.1 - 7.1 6.4 37.1 12 5.6 37.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CBP_BcsG PF11658.8 CDI77727.1 - 7.3 4.9 18.6 13 4.0 18.6 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG PTPRCAP PF15713.5 CDI77727.1 - 9 6.6 29.6 23 5.2 29.6 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Neur_chan_memb PF02932.16 CDI77727.1 - 9.4 6.2 27.7 1.6 8.8 22.8 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 CDI77729.1 - 2 7.1 27.3 2.3 6.9 27.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_M16_M PF16187.5 CDI77730.1 - 2.6e-27 95.8 0.2 2.6e-27 95.8 0.2 2.9 4 0 0 4 4 4 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 CDI77730.1 - 2.2e-11 44.1 5.2 1.1e-08 35.3 0.0 3.5 2 1 0 2 2 2 2 Peptidase M16 inactive domain RNA_pol_Rpc4 PF05132.14 CDI77730.1 - 0.16 12.4 24.7 0.68 10.3 3.9 3.8 3 0 0 3 3 3 0 RNA polymerase III RPC4 SSP160 PF06933.11 CDI77730.1 - 3.3 5.8 13.7 5.5 5.1 13.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Spt20 PF12090.8 CDI77733.1 - 0.0015 18.2 8.5 0.0015 18.2 8.5 4.7 5 1 0 5 5 5 3 Spt20 family FAST_1 PF06743.15 CDI77733.1 - 0.72 9.8 4.5 0.91 9.5 0.5 3.0 2 1 1 3 3 3 0 FAST kinase-like protein, subdomain 1 Rxt3 PF08642.10 CDI77733.1 - 3 8.6 5.3 1.3 9.8 0.4 2.9 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 F-protein PF00469.20 CDI77733.1 - 9.9 5.7 10.4 1.4 8.4 4.3 2.4 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef SNF2_N PF00176.23 CDI77734.1 - 1.5e-60 204.8 6.0 1.5e-58 198.3 4.2 3.5 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI77734.1 - 1e-19 70.9 0.0 6.5e-18 65.1 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI77734.1 - 2.2e-08 34.3 0.0 2.2e-08 34.3 0.0 2.9 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDI77734.1 - 8.8e-06 25.6 0.2 3.6e-05 23.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase SR-25 PF10500.9 CDI77736.1 - 0.00093 18.9 16.4 0.00099 18.8 16.4 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI77736.1 - 0.067 13.9 12.7 0.1 13.3 12.7 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein HGTP_anticodon2 PF12745.7 CDI77736.1 - 0.48 9.9 7.1 0.53 9.8 7.1 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Pox_A12 PF04651.13 CDI77736.1 - 0.59 10.2 10.1 0.76 9.8 10.1 1.1 1 0 0 1 1 1 0 Poxvirus A12 protein RAP1 PF07218.11 CDI77736.1 - 9.6 4.3 8.5 9.3 4.4 8.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Suf PF05843.14 CDI77737.1 - 4.1 7.3 5.2 5.5 6.9 5.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TPR_2 PF07719.17 CDI77738.1 - 0.003 17.6 1.4 0.24 11.6 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat RRM_1 PF00076.22 CDI77739.1 - 9.9e-16 57.3 0.0 1.4e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Str_synth PF03088.16 CDI77740.1 - 2.3e-07 30.8 0.0 4.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Strictosidine synthase SGL PF08450.12 CDI77740.1 - 5.3e-05 22.9 0.0 0.00025 20.7 0.0 1.9 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region UvrD_C PF13361.6 CDI77740.1 - 0.0012 18.3 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain RskA PF10099.9 CDI77740.1 - 1.5 9.1 15.6 6.5 7.0 8.4 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA AAA_23 PF13476.6 CDI77740.1 - 2.5 8.6 20.8 3.8 8.0 20.8 1.2 1 0 0 1 1 1 0 AAA domain Thioredoxin_4 PF13462.6 CDI77740.1 - 2.6 8.2 9.2 5.2 7.2 9.2 1.4 1 0 0 1 1 1 0 Thioredoxin FapA PF03961.13 CDI77740.1 - 8 4.9 10.6 11 4.5 10.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Methyltransf_25 PF13649.6 CDI77742.1 - 3.8e-20 72.4 0.0 2.1e-19 70.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI77742.1 - 4.9e-20 72.0 0.0 3e-19 69.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI77742.1 - 7.8e-17 61.6 0.0 1.3e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI77742.1 - 1.6e-15 57.2 0.0 2.7e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDI77742.1 - 2.5e-12 46.6 0.0 3.8e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CDI77742.1 - 1.2e-11 44.4 0.0 7.1e-09 35.3 0.0 2.3 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CDI77742.1 - 6e-11 43.0 0.0 2.4e-10 41.0 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CDI77742.1 - 5.1e-07 29.4 0.0 1.1e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CDI77742.1 - 0.00039 20.2 0.0 0.0015 18.3 0.0 1.9 3 0 0 3 3 3 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 CDI77742.1 - 0.00042 19.7 0.0 0.00064 19.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain CheR PF01739.18 CDI77742.1 - 0.0005 19.6 0.0 0.04 13.4 0.0 2.2 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_PK PF05891.12 CDI77742.1 - 0.0011 18.5 0.0 0.025 14.1 0.0 2.0 1 1 1 2 2 2 2 AdoMet dependent proline di-methyltransferase FtsJ PF01728.19 CDI77742.1 - 0.0014 18.8 0.0 0.0082 16.3 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CDI77742.1 - 0.0085 15.6 0.1 0.037 13.5 0.0 1.9 2 1 0 2 2 2 1 Putative methyltransferase TehB PF03848.14 CDI77742.1 - 0.011 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 CDI77742.1 - 0.011 14.7 0.0 0.019 13.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) NodS PF05401.11 CDI77742.1 - 0.024 14.3 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) DOT1 PF08123.13 CDI77742.1 - 0.027 14.0 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 RrnaAD PF00398.20 CDI77742.1 - 0.028 13.5 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PrmA PF06325.13 CDI77742.1 - 0.073 12.5 1.2 0.097 12.0 0.2 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_5 PF01795.19 CDI77742.1 - 0.1 12.1 0.0 0.76 9.2 0.0 2.1 2 0 0 2 2 2 0 MraW methylase family Peptidase_S66 PF02016.15 CDI77742.1 - 0.22 11.6 0.6 2.7 8.1 0.1 2.5 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain F5_F8_type_C PF00754.25 CDI77743.1 - 1.5e-06 28.4 0.0 0.024 14.7 0.0 3.5 3 1 0 3 3 3 2 F5/8 type C domain EcpB_C PF18649.1 CDI77743.1 - 0.0067 16.4 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 EcpB C-terminal domain LCCL PF03815.19 CDI77744.1 - 7.4e-13 48.4 0.1 1.2e-12 47.8 0.1 1.3 1 0 0 1 1 1 1 LCCL domain Rxt3 PF08642.10 CDI77744.1 - 0.032 15.0 0.1 0.11 13.3 0.1 2.0 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Plasmid_stab_B PF10784.9 CDI77744.1 - 0.067 13.0 0.3 0.14 12.0 0.3 1.5 1 0 0 1 1 1 0 Plasmid stability protein Ribosomal_60s PF00428.19 CDI77744.1 - 2.1 9.0 11.3 5.2 7.7 3.6 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Mitofilin PF09731.9 CDI77745.1 - 0.0022 16.9 29.9 0.0022 16.9 29.9 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein TFIIA PF03153.13 CDI77745.1 - 0.046 13.7 41.3 0.055 13.5 41.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI77745.1 - 0.9 7.7 31.5 0.98 7.6 31.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 CDI77745.1 - 1.4 7.5 20.8 1.5 7.4 20.8 1.1 1 0 0 1 1 1 0 Hamartin protein Fmp27_WPPW PF10359.9 CDI77745.1 - 2.1 7.1 25.6 2.8 6.7 25.6 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain LMBR1 PF04791.16 CDI77745.1 - 5 5.9 10.0 5.9 5.7 10.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Asp-B-Hydro_N PF05279.11 CDI77745.1 - 7.8 6.5 40.7 10 6.1 40.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Borrelia_P83 PF05262.11 CDI77745.1 - 7.8 4.9 34.8 8.7 4.7 34.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein ACOX PF01756.19 CDI77746.1 - 6.1e-39 133.4 0.3 6.1e-39 133.4 0.3 1.4 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 CDI77746.1 - 0.0018 18.5 0.6 0.27 11.5 0.0 2.8 2 1 1 3 3 3 2 Acyl-CoA dehydrogenase, C-terminal domain TFIIA PF03153.13 CDI77747.1 - 0.25 11.3 4.4 0.43 10.5 4.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI77748.1 - 0.26 11.2 17.3 1.2 9.0 7.7 4.0 4 0 0 4 4 4 0 SPX domain Condensin2nSMC PF12422.8 CDI77748.1 - 0.59 10.3 2.5 3.5 7.8 0.0 2.9 3 0 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit SMC_N PF02463.19 CDI77751.1 - 0.00012 21.6 0.1 0.00014 21.4 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CDI77751.1 - 0.056 13.7 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Thioredoxin PF00085.20 CDI77753.1 - 3.1e-09 36.7 0.0 3.4e-06 27.0 0.0 3.1 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 CDI77753.1 - 2.1e-07 31.0 3.7 0.0014 18.5 2.5 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDI77753.1 - 3.7e-05 24.1 0.0 0.36 11.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDI77753.1 - 0.00011 22.4 0.3 0.69 10.3 0.1 3.4 3 1 0 3 3 3 2 Thioredoxin-like OST3_OST6 PF04756.13 CDI77753.1 - 0.00084 18.8 1.3 0.2 11.0 0.6 2.3 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family AlaDh_PNT_C PF01262.21 CDI77754.1 - 2e-74 249.5 0.2 2.6e-74 249.1 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDI77754.1 - 4.3e-36 124.2 0.1 1.1e-20 74.3 0.1 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 CDI77754.1 - 3.3e-06 26.6 0.0 3.5e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 CDI77754.1 - 0.00028 21.4 0.1 0.00058 20.4 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDI77754.1 - 0.00057 19.2 0.1 0.00077 18.8 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CDI77754.1 - 0.001 19.1 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CDI77754.1 - 0.0012 19.2 0.1 0.0025 18.2 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding GIDA PF01134.22 CDI77754.1 - 0.0026 16.9 0.1 0.0038 16.4 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 CDI77754.1 - 0.0072 15.1 1.2 0.01 14.6 1.2 1.1 1 0 0 1 1 1 1 HI0933-like protein 3HCDH_N PF02737.18 CDI77754.1 - 0.014 15.3 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CDI77754.1 - 0.022 15.0 3.1 0.17 12.1 1.1 2.7 3 0 0 3 3 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDI77754.1 - 0.025 14.2 2.3 0.052 13.1 2.3 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDI77754.1 - 0.025 13.7 3.7 0.038 13.1 3.7 1.2 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 CDI77754.1 - 0.035 13.7 0.5 0.11 12.0 0.7 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CDI77754.1 - 0.059 13.6 0.3 0.31 11.3 0.2 2.1 2 0 0 2 2 2 0 TrkA-N domain FAD_oxidored PF12831.7 CDI77754.1 - 0.086 12.2 3.8 0.12 11.7 3.8 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDI77754.1 - 0.12 11.6 1.5 0.22 10.7 1.5 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 CDI77754.1 - 0.26 10.5 0.4 0.44 9.8 0.4 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 CDI77754.1 - 0.44 9.8 5.3 18 4.6 0.0 2.7 2 1 1 3 3 3 0 ThiF family ACP_syn_III PF08545.10 CDI77756.1 - 4.6e-24 84.1 2.9 5.2e-24 83.9 0.4 2.4 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 CDI77756.1 - 1.8e-21 76.1 3.6 3.4e-11 43.2 0.1 3.4 2 1 1 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Spt20 PF12090.8 CDI77756.1 - 0.007 16.0 1.2 0.0098 15.5 1.2 1.3 1 0 0 1 1 1 1 Spt20 family Pex14_N PF04695.13 CDI77756.1 - 0.0084 16.8 0.2 0.019 15.6 0.1 1.7 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SUIM_assoc PF16619.5 CDI77756.1 - 0.016 15.2 5.9 0.032 14.3 5.9 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Roughex PF06020.11 CDI77756.1 - 0.28 10.2 0.9 0.59 9.2 1.2 1.4 2 0 0 2 2 2 0 Drosophila roughex protein Med3 PF11593.8 CDI77756.1 - 1.8 7.7 7.7 3.1 6.9 7.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PGM_PMM_I PF02878.16 CDI77757.1 - 4.2e-39 133.4 0.0 1.2e-38 132.0 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CDI77757.1 - 3.1e-20 72.7 0.0 1.4e-19 70.6 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CDI77757.1 - 1e-06 28.9 0.0 2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Peripla_BP_4 PF13407.6 CDI77757.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein domain PDEase_I_N PF08499.12 CDI77757.1 - 0.32 10.9 1.3 0.62 9.9 0.2 2.1 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal Pkinase PF00069.25 CDI77758.1 - 4.3e-15 55.8 11.5 1.7e-07 30.9 0.1 5.0 3 1 0 3 3 3 2 Protein kinase domain DUF913 PF06025.12 CDI77758.1 - 0.0015 17.6 5.2 0.0015 17.6 5.2 8.3 4 2 0 4 4 4 2 Domain of Unknown Function (DUF913) Suf PF05843.14 CDI77758.1 - 0.0025 17.8 16.1 0.0025 17.8 16.1 9.0 4 3 1 5 5 5 1 Suppressor of forked protein (Suf) Pkinase_Tyr PF07714.17 CDI77758.1 - 0.004 16.5 10.0 0.17 11.1 0.3 3.3 3 0 0 3 3 3 2 Protein tyrosine kinase FA_desaturase PF00487.24 CDI77758.1 - 0.14 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Fatty acid desaturase LptF_LptG PF03739.14 CDI77758.1 - 3.1 6.5 4.7 7.6 5.3 4.7 1.7 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Peptidase_C12 PF01088.21 CDI77759.1 - 2.9e-43 148.1 2.5 8e-39 133.6 0.2 2.5 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 CDI77759.1 - 8.1e-18 64.1 3.8 8.1e-18 64.1 3.8 2.4 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolases Apc15p PF05841.11 CDI77759.1 - 0.64 10.8 7.6 0.21 12.4 1.5 2.3 2 0 0 2 2 2 0 Apc15p protein RAP1 PF07218.11 CDI77759.1 - 5.3 5.2 9.0 0.13 10.5 2.4 1.6 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) CCSAP PF15748.5 CDI77759.1 - 10 6.2 14.9 2.1 8.4 4.4 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Plasmodium_Vir PF05795.11 CDI77761.1 - 0.00048 19.7 0.7 0.00048 19.7 0.7 2.1 1 1 1 2 2 2 1 Plasmodium vivax Vir protein Borrelia_P83 PF05262.11 CDI77761.1 - 0.0026 16.3 23.3 0.0028 16.2 23.3 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein PNISR PF15996.5 CDI77761.1 - 0.0082 16.4 38.9 0.0082 16.4 38.9 1.6 2 0 0 2 2 2 1 Arginine/serine-rich protein PNISR SOG2 PF10428.9 CDI77761.1 - 0.021 14.0 23.6 0.085 12.0 15.0 2.0 2 0 0 2 2 2 0 RAM signalling pathway protein DUF1180 PF06679.12 CDI77761.1 - 0.059 13.8 0.5 0.059 13.8 0.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) vATP-synt_E PF01991.18 CDI77762.1 - 0.84 9.0 5.4 1.2 8.5 5.4 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Ank_3 PF13606.6 CDI77763.1 - 1.8e-05 24.7 0.0 0.32 11.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat SUIM_assoc PF16619.5 CDI77763.1 - 0.00082 19.4 25.5 0.0045 17.0 3.6 3.6 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 Ank_2 PF12796.7 CDI77763.1 - 0.001 19.6 0.0 0.0021 18.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI77763.1 - 0.0089 16.6 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) GxGYxYP_C PF14323.6 CDI77763.1 - 0.2 11.5 2.0 0.19 11.5 0.9 1.5 1 1 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain TFIIA PF03153.13 CDI77763.1 - 0.23 11.4 30.9 0.34 10.9 30.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MMR1 PF08505.10 CDI77763.1 - 0.44 10.8 14.0 0.73 10.1 14.0 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein BAF1_ABF1 PF04684.13 CDI77763.1 - 0.5 9.4 12.4 0.74 8.8 12.4 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CSG2 PF16965.5 CDI77763.1 - 0.54 9.1 1.9 0.67 8.8 1.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PAT1 PF09770.9 CDI77763.1 - 1.1 7.4 21.6 1.1 7.4 21.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Herpes_capsid PF06112.11 CDI77763.1 - 1.6 8.7 17.0 2.7 8.0 17.0 1.3 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein DUF572 PF04502.13 CDI77763.1 - 2.3 7.7 13.0 3.3 7.2 13.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lin-8 PF03353.15 CDI77763.1 - 3 7.3 14.6 4.7 6.7 14.6 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Hid1 PF12722.7 CDI77763.1 - 3.2 5.8 13.2 4 5.5 13.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI77763.1 - 3.9 4.5 13.2 3.9 4.5 13.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer V_ATPase_I PF01496.19 CDI77763.1 - 6.8 4.5 8.2 8.4 4.2 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PH_5 PF15405.6 CDI77764.1 - 0.028 14.5 0.6 0.028 14.5 0.6 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain RAP1 PF07218.11 CDI77764.1 - 3.2 5.9 11.9 3.7 5.7 11.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SSP160 PF06933.11 CDI77764.1 - 3.6 5.7 20.1 4.8 5.3 20.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SAP18 PF06487.12 CDI77765.1 - 7e-21 74.9 0.0 7e-21 74.9 0.0 3.2 2 1 0 2 2 2 1 Sin3 associated polypeptide p18 (SAP18) Phage_holin_3_3 PF16083.5 CDI77765.1 - 0.95 9.6 4.5 2.3 8.4 3.4 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III PP2C PF00481.21 CDI77766.1 - 5.1e-60 203.3 0.3 5.1e-60 203.3 0.3 3.3 4 1 0 4 4 4 1 Protein phosphatase 2C SPX PF03105.19 CDI77766.1 - 0.001 19.1 0.0 0.001 19.1 0.0 10.1 4 3 2 7 7 7 2 SPX domain DUF2722 PF10846.8 CDI77766.1 - 0.001 18.1 14.4 0.001 18.1 14.4 10.6 8 2 1 10 10 10 2 Protein of unknown function (DUF2722) Neur_chan_memb PF02932.16 CDI77767.1 - 8.1e-05 22.8 3.7 8.1e-05 22.8 3.7 6.4 4 1 1 5 5 5 2 Neurotransmitter-gated ion-channel transmembrane region DUF2722 PF10846.8 CDI77767.1 - 0.0011 18.1 14.6 0.0011 18.1 14.6 10.3 8 2 2 10 10 10 4 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI77767.1 - 0.0017 17.4 57.5 0.0017 17.4 57.5 6.7 6 0 0 6 6 6 1 Transcriptional activator LAG-3 Sugar_tr PF00083.24 CDI77767.1 - 0.0033 16.4 0.1 0.0033 16.4 0.1 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter RNA_pol_Rpc4 PF05132.14 CDI77767.1 - 0.0044 17.5 1.4 0.0044 17.5 1.4 10.6 7 3 4 11 11 11 1 RNA polymerase III RPC4 OATP PF03137.20 CDI77767.1 - 0.013 13.8 0.1 0.013 13.8 0.1 9.0 6 2 2 8 8 8 0 Organic Anion Transporter Polypeptide (OATP) family RskA PF10099.9 CDI77767.1 - 0.058 13.7 0.0 0.039 14.3 10.6 14.4 3 3 5 10 10 10 0 Anti-sigma-K factor rskA BLOC1_2 PF10046.9 CDI77769.1 - 0.055 13.8 5.1 2.7 8.3 0.4 3.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ArdA PF07275.11 CDI77769.1 - 0.11 13.1 4.8 7.2 7.2 0.0 3.0 3 0 0 3 3 3 0 Antirestriction protein (ArdA) Nucleoporin_FG PF13634.6 CDI77770.1 - 5.7e-08 33.5 32.9 5.7e-08 33.5 32.9 11.0 8 1 3 11 11 11 3 Nucleoporin FG repeat region CBF PF03914.17 CDI77771.1 - 2.2e-11 44.1 0.5 2.2e-11 44.1 0.5 7.3 8 2 0 8 8 8 1 CBF/Mak21 family DUF4834 PF16118.5 CDI77771.1 - 8.5e-05 23.4 2.4 8.5e-05 23.4 2.4 21.0 19 6 1 20 20 20 1 Domain of unknown function (DUF4834) RskA PF10099.9 CDI77771.1 - 0.00019 21.8 5.3 0.00019 21.8 5.3 20.3 8 5 6 17 17 17 5 Anti-sigma-K factor rskA COPI_assoc PF08507.10 CDI77771.1 - 0.23 11.5 0.1 0.92 9.6 0.1 2.0 1 0 0 1 1 1 0 COPI associated protein DUF2207 PF09972.9 CDI77771.1 - 4.5 5.9 4.6 3.9 6.1 0.1 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) RskA PF10099.9 CDI77772.1 - 4.7 7.5 0.0 4.7 7.5 0.0 12.5 2 1 6 9 9 9 0 Anti-sigma-K factor rskA PAP1 PF08601.10 CDI77773.1 - 4.3e-06 26.7 6.4 5.1e-06 26.5 6.4 1.2 1 0 0 1 1 1 1 Transcription factor PAP1 PRP3 PF08572.10 CDI77773.1 - 0.0031 17.3 0.6 0.0045 16.8 0.6 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) Apt1 PF10351.9 CDI77773.1 - 0.028 13.3 13.5 0.035 13.0 13.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 CDI77773.1 - 0.18 11.0 16.5 0.21 10.7 16.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein ANAPC1 PF12859.7 CDI77773.1 - 0.24 12.0 4.8 0.39 11.3 4.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 Nucleo_P87 PF07267.11 CDI77773.1 - 0.32 9.8 4.1 0.38 9.6 4.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM76 PF16046.5 CDI77773.1 - 0.33 10.3 9.8 0.42 9.9 9.8 1.1 1 0 0 1 1 1 0 FAM76 protein Macoilin PF09726.9 CDI77773.1 - 0.34 9.4 14.9 0.45 9.0 14.9 1.2 1 0 0 1 1 1 0 Macoilin family Tmemb_cc2 PF10267.9 CDI77773.1 - 0.62 9.1 8.5 0.73 8.9 8.5 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SRP-alpha_N PF04086.13 CDI77773.1 - 1.1 9.1 14.0 1.3 8.9 14.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TMA7 PF09072.10 CDI77773.1 - 1.7 9.6 0.0 1.7 9.6 0.0 2.9 3 1 0 3 3 3 0 Translation machinery associated TMA7 ZapB PF06005.12 CDI77773.1 - 2.2 8.8 8.2 0.14 12.6 2.5 1.9 2 0 0 2 2 2 0 Cell division protein ZapB GREB1 PF15782.5 CDI77773.1 - 2.4 5.2 10.1 2.4 5.1 10.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3807 PF12720.7 CDI77773.1 - 3.6 7.8 11.6 1.9 8.7 3.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF1075 PF06388.11 CDI77773.1 - 4.8 7.3 7.9 4.7 7.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1075) Ndc1_Nup PF09531.10 CDI77773.1 - 4.9 5.7 13.4 6.2 5.4 13.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SR-25 PF10500.9 CDI77773.1 - 6.1 6.4 38.6 22 4.5 38.4 1.8 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Peptidase_S64 PF08192.11 CDI77773.1 - 7.3 4.9 10.9 8.7 4.7 10.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 Miga PF10265.9 CDI77773.1 - 7.9 5.3 11.5 11 4.9 11.5 1.1 1 0 0 1 1 1 0 Mitoguardin SSP160 PF06933.11 CDI77773.1 - 9.3 4.3 22.3 12 4.0 22.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Radical_SAM PF04055.21 CDI77774.1 - 1.4e-08 35.3 0.0 2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 CDI77774.1 - 9.9e-07 29.2 0.0 3.7e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family TFIIA PF03153.13 CDI77776.1 - 0.01 15.9 18.4 0.017 15.1 18.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI77776.1 - 0.032 14.3 31.5 0.073 13.1 0.1 4.0 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Tim54 PF11711.8 CDI77776.1 - 0.17 10.6 2.3 0.59 8.9 0.2 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Lin-8 PF03353.15 CDI77776.1 - 5.6 6.4 15.3 0.092 12.3 5.4 2.0 1 1 1 2 2 2 0 Ras-mediated vulval-induction antagonist zf-Tim10_DDP PF02953.15 CDI77777.1 - 7.4e-12 44.7 2.2 9.8e-12 44.3 1.6 1.6 1 1 0 1 1 1 1 Tim10/DDP family zinc finger LRR_4 PF12799.7 CDI77778.1 - 5.6e-07 29.8 16.9 2e-05 24.9 3.5 3.0 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI77778.1 - 2.1e-05 24.2 21.0 0.0011 18.7 2.7 3.1 1 1 3 4 4 4 3 Leucine rich repeat PIP5K PF01504.18 CDI77778.1 - 0.0011 18.3 5.0 0.0011 18.3 5.0 2.3 3 1 0 3 3 3 1 Phosphatidylinositol-4-phosphate 5-Kinase LRR_9 PF14580.6 CDI77778.1 - 0.0012 18.3 2.0 0.0012 18.3 2.0 1.9 1 1 0 1 1 1 1 Leucine-rich repeat TCP PF03634.13 CDI77778.1 - 0.015 15.9 13.0 0.015 15.9 13.0 3.5 2 1 0 2 2 1 0 TCP family transcription factor SID-1_RNA_chan PF13965.6 CDI77778.1 - 0.25 9.7 5.2 0.41 9.0 5.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LRR_6 PF13516.6 CDI77778.1 - 0.26 11.5 3.1 1.3 9.3 0.1 3.2 3 0 0 3 3 3 0 Leucine Rich repeat Pkinase_fungal PF17667.1 CDI77778.1 - 1.8 7.3 14.7 0.066 12.0 7.7 2.0 2 0 0 2 2 2 0 Fungal protein kinase Folate_carrier PF01770.18 CDI77778.1 - 2.6 6.7 8.9 7.2 5.2 8.9 1.8 1 0 0 1 1 1 0 Reduced folate carrier Peptidase_S8 PF00082.22 CDI77778.1 - 5.2 6.2 11.8 0.025 13.8 1.5 2.3 2 0 0 2 2 2 0 Subtilase family HCO3_cotransp PF00955.21 CDI77778.1 - 8.3 5.1 11.1 14 4.3 11.1 1.3 1 0 0 1 1 1 0 HCO3- transporter family Spt20 PF12090.8 CDI77779.1 - 0.004 16.8 16.0 0.004 16.8 16.0 6.8 6 1 1 7 7 7 1 Spt20 family Metallophos PF00149.28 CDI77780.1 - 8.8e-12 46.0 0.0 1.4e-11 45.3 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SUIM_assoc PF16619.5 CDI77780.1 - 0.00028 20.9 0.0 0.00069 19.6 0.0 1.7 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI77780.1 - 0.016 14.9 12.6 0.024 14.3 12.6 1.2 1 0 0 1 1 1 0 Spt20 family CBP_BcsG PF11658.8 CDI77780.1 - 0.098 11.0 1.8 0.15 10.4 1.8 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG SUIM_assoc PF16619.5 CDI77783.1 - 0.12 12.4 26.5 0.85 9.7 9.1 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 THRAP3_BCLAF1 PF15440.6 CDI77783.1 - 0.34 9.9 7.3 0.37 9.7 7.3 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family V_ATPase_I PF01496.19 CDI77783.1 - 0.43 8.4 7.5 0.48 8.3 7.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4045 PF13254.6 CDI77783.1 - 6 6.4 12.8 7.3 6.1 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) USP8_interact PF08941.10 CDI77783.1 - 6.3 6.6 10.6 0.19 11.6 2.1 2.0 2 0 0 2 2 2 0 USP8 interacting Pkinase PF00069.25 CDI77785.1 - 1.6e-51 175.2 0.1 7e-23 81.3 0.0 4.0 2 1 2 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77785.1 - 7.2e-22 77.9 3.7 2.9e-15 56.3 0.1 3.8 3 2 0 3 3 3 3 Protein tyrosine kinase DUF3824 PF12868.7 CDI77785.1 - 0.0055 17.4 12.5 0.0055 17.4 12.5 7.5 5 3 3 8 8 8 1 Domain of unknwon function (DUF3824) TERB2 PF15101.6 CDI77785.1 - 0.01 15.9 7.5 0.01 15.9 7.5 4.2 3 1 2 5 5 5 0 Telomere-associated protein TERB2 TCP PF03634.13 CDI77785.1 - 0.07 13.7 31.6 0.94 10.0 5.1 3.7 3 0 0 3 3 3 0 TCP family transcription factor SR-25 PF10500.9 CDI77785.1 - 3.1 7.3 38.8 6.4 6.3 20.6 3.3 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein SpoIIP PF07454.11 CDI77785.1 - 4.5 6.7 26.7 5.9 6.3 13.5 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI77785.1 - 9.8 5.1 32.2 6.3 5.7 8.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 zinc_ribbon_2 PF13240.6 CDI77786.1 - 0.042 13.6 0.9 0.072 12.8 0.9 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DUF35_N PF12172.8 CDI77786.1 - 1.8 8.5 7.5 2.1 8.3 2.4 2.7 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) POP1 PF06978.11 CDI77787.1 - 3.5e-24 86.0 14.5 6.9e-15 55.6 0.2 6.6 6 1 1 7 7 7 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 CDI77787.1 - 1.5e-19 70.1 0.0 1.5e-19 70.1 0.0 5.8 6 1 1 7 7 7 1 POPLD (NUC188) domain SR-25 PF10500.9 CDI77787.1 - 0.0015 18.2 12.5 0.0015 18.2 12.5 8.6 8 0 0 8 8 8 4 Nuclear RNA-splicing-associated protein DcuC PF03606.15 CDI77787.1 - 0.0044 15.5 0.5 0.0044 15.5 0.5 2.3 3 0 0 3 3 3 1 C4-dicarboxylate anaerobic carrier ETRAMP PF09716.10 CDI77787.1 - 1.4 9.0 0.0 1.4 9.0 0.0 6.3 8 0 0 8 8 8 0 Malarial early transcribed membrane protein (ETRAMP) HU-CCDC81_bac_2 PF18175.1 CDI77789.1 - 0.13 12.1 0.6 0.23 11.3 0.1 1.6 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 UQ_con PF00179.26 CDI77790.1 - 2.9e-17 62.6 0.0 4.9e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 CDI77790.1 - 0.019 14.6 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 SOBP PF15279.6 CDI77791.1 - 2.3 8.8 16.6 2.7 8.5 16.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein NST1 PF13945.6 CDI77791.1 - 3.2 7.8 21.2 0.24 11.5 15.5 1.8 1 1 1 2 2 2 0 Salt tolerance down-regulator FAM176 PF14851.6 CDI77791.1 - 3.7 7.2 6.6 7.6 6.2 6.6 1.5 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI77791.1 - 3.7 7.2 8.7 6.3 6.5 8.7 1.3 1 0 0 1 1 1 0 Connexin EMC3_TMCO1 PF01956.16 CDI77791.1 - 7.8 6.2 6.5 10 5.8 6.5 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RNase_P_p30 PF01876.16 CDI77792.1 - 1.9e-20 73.3 0.3 1.5e-16 60.6 0.3 3.7 3 1 0 3 3 3 2 RNase P subunit p30 OsmC PF02566.19 CDI77792.1 - 4.7 7.7 0.0 4.7 7.7 0.0 5.0 5 1 1 6 6 6 0 OsmC-like protein DEAD PF00270.29 CDI77793.1 - 3.8e-34 118.0 8.5 3.8e-34 118.0 8.5 3.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI77793.1 - 3e-20 72.6 5.3 3.9e-19 69.0 0.0 3.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDI77793.1 - 1.7e-10 40.9 0.1 5.6e-10 39.3 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) TFIIA PF03153.13 CDI77793.1 - 0.0049 16.9 19.4 0.0049 16.9 19.4 5.7 4 1 1 5 5 5 3 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 CDI77794.1 - 2.5e-05 24.1 15.3 3.5e-05 23.6 15.3 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Spt20 PF12090.8 CDI77794.1 - 0.0062 16.2 14.1 0.0062 16.2 14.1 3.5 2 1 0 2 2 2 1 Spt20 family Rtf2 PF04641.12 CDI77794.1 - 0.042 13.2 26.2 0.06 12.7 26.2 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Utp14 PF04615.13 CDI77794.1 - 0.24 9.9 22.9 0.31 9.6 22.9 1.1 1 0 0 1 1 1 0 Utp14 protein Ric8 PF10165.9 CDI77794.1 - 5.3 6.0 31.5 1.6 7.7 4.4 2.1 1 1 1 2 2 2 0 Guanine nucleotide exchange factor synembryn Methyltransf_23 PF13489.6 CDI77795.1 - 4.9e-10 39.5 0.0 4.9e-10 39.5 0.0 2.8 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI77795.1 - 2e-07 31.6 1.7 4.4e-05 24.1 0.7 3.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI77795.1 - 1.3e-05 25.7 3.4 0.13 13.0 0.3 3.2 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 CDI77795.1 - 0.00037 21.2 4.7 0.0063 17.2 0.3 3.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI77795.1 - 0.0011 18.8 16.3 0.002 18.0 0.1 3.9 4 0 0 4 4 4 2 Methyltransferase domain FtsJ PF01728.19 CDI77795.1 - 0.006 16.7 2.9 0.0074 16.4 0.1 2.5 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_24 PF13578.6 CDI77795.1 - 0.25 12.4 2.5 4.2 8.4 2.5 3.0 1 1 0 1 1 1 0 Methyltransferase domain Rxt3 PF08642.10 CDI77795.1 - 5.3 7.8 12.5 3.3 8.5 1.8 3.9 4 0 0 4 4 4 0 Histone deacetylation protein Rxt3 DUF2407 PF10302.9 CDI77797.1 - 0.0041 17.7 0.8 0.0041 17.7 0.8 2.2 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain RsmJ PF04378.13 CDI77797.1 - 0.097 11.9 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ eIF-3_zeta PF05091.12 CDI77797.1 - 0.41 9.6 6.6 0.056 12.4 2.7 1.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4578 PF15147.6 CDI77797.1 - 10 7.1 18.4 0.086 13.7 3.9 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4578) eIF3g PF12353.8 CDI77798.1 - 3.2e-12 46.9 4.3 3.2e-12 46.9 4.3 2.7 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G Menin PF05053.13 CDI77798.1 - 0.0034 15.8 6.5 0.004 15.6 6.5 1.1 1 0 0 1 1 1 1 Menin Macoilin PF09726.9 CDI77798.1 - 0.006 15.2 16.6 0.0075 14.9 16.6 1.0 1 0 0 1 1 1 1 Macoilin family DUF2407_C PF13373.6 CDI77798.1 - 0.092 12.9 0.3 0.18 12.0 0.3 1.5 1 0 0 1 1 1 0 DUF2407 C-terminal domain QWRF PF04484.12 CDI77798.1 - 1.3 8.7 15.4 1.8 8.2 15.4 1.1 1 0 0 1 1 1 0 QWRF family DUF4692 PF15763.5 CDI77799.1 - 0.025 15.1 1.1 0.031 14.7 1.1 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) TFIIA PF03153.13 CDI77800.1 - 0.005 16.9 35.3 0.005 16.9 35.3 5.1 3 2 0 4 4 4 1 Transcription factor IIA, alpha/beta subunit CPSF73-100_C PF11718.8 CDI77800.1 - 0.37 10.3 4.7 3 7.3 0.0 2.8 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Swi6_N PF18530.1 CDI77800.1 - 2.2 8.5 4.0 5.4 7.2 4.0 1.6 1 0 0 1 1 1 0 Swi6 N-terminal domain V_ATPase_I PF01496.19 CDI77800.1 - 9 4.1 9.8 17 3.1 9.8 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RPA43_OB PF17875.1 CDI77800.1 - 10 6.8 9.0 45 4.7 4.9 3.1 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I DA1-like PF12315.8 CDI77801.1 - 3.6e-11 42.8 8.3 8.4e-09 35.1 8.3 2.9 1 1 0 1 1 1 1 Protein DA1 LIM PF00412.22 CDI77801.1 - 0.0021 18.3 34.1 0.019 15.2 0.4 5.2 5 1 1 6 6 6 4 LIM domain EF-hand_7 PF13499.6 CDI77802.1 - 4.2e-08 33.5 0.1 1.2e-07 32.1 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CDI77802.1 - 7.8e-06 25.1 1.4 0.1 12.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CDI77802.1 - 8.4e-05 22.2 1.3 0.12 12.3 0.2 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 CDI77802.1 - 0.038 13.8 0.2 0.12 12.3 0.1 1.8 1 1 1 2 2 2 0 EF-hand domain pair SPX PF03105.19 CDI77803.1 - 9.1e-05 22.5 1.6 9.1e-05 22.5 1.6 8.1 3 1 3 6 6 6 2 SPX domain PHD PF00628.29 CDI77803.1 - 0.00077 19.3 8.1 0.0052 16.6 5.6 3.2 2 0 0 2 2 2 1 PHD-finger Pex14_N PF04695.13 CDI77803.1 - 0.088 13.5 0.2 0.088 13.5 0.2 12.1 7 2 3 10 10 10 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zf_RING PF16744.5 CDI77803.1 - 0.64 10.2 5.9 0.29 11.3 0.9 3.1 2 0 0 2 2 2 0 KIAA1045 RING finger Med15 PF09606.10 CDI77804.1 - 0.048 12.4 95.7 0.029 13.1 28.3 2.1 1 1 1 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal zf-MIZ PF02891.20 CDI77805.1 - 5.4e-07 29.3 7.1 2.6e-05 23.9 0.0 3.3 3 0 0 3 3 3 2 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 CDI77805.1 - 1.1 9.1 5.1 9.6 6.1 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RskA PF10099.9 CDI77810.1 - 0.12 12.6 4.6 0.13 12.6 4.6 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Conotoxin PF02950.17 CDI77810.1 - 0.32 12.0 5.8 0.47 11.5 5.8 1.3 1 0 0 1 1 1 0 Conotoxin DUF5061 PF16587.5 CDI77810.1 - 0.35 10.9 7.3 0.57 10.3 7.3 1.4 1 1 0 1 1 1 0 17 kDa common-antigen outer membrane protein FAM176 PF14851.6 CDI77810.1 - 0.39 10.4 5.3 0.44 10.2 5.3 1.1 1 0 0 1 1 1 0 FAM176 family DUF4834 PF16118.5 CDI77810.1 - 0.88 10.6 11.7 0.87 10.6 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI77810.1 - 1.2 8.7 29.2 1.1 8.8 29.2 1.0 1 0 0 1 1 1 0 Spt20 family Renin_r PF07850.14 CDI77810.1 - 2.5 8.8 4.5 3.1 8.5 4.5 1.1 1 0 0 1 1 1 0 Renin receptor-like protein eIF-3_zeta PF05091.12 CDI77810.1 - 4.1 6.3 14.1 4.4 6.2 14.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI77810.1 - 4.4 6.0 10.7 4.4 6.0 10.7 1.0 1 0 0 1 1 1 0 Presenilin AMA-1 PF02430.15 CDI77811.1 - 5e-35 121.4 0.1 1.9e-20 73.3 0.0 3.1 1 1 2 3 3 3 3 Apical membrane antigen 1 DUF755 PF05501.11 CDI77812.1 - 0.0081 16.4 20.4 0.0081 16.4 20.4 6.7 6 0 0 6 6 6 2 Domain of unknown function (DUF755) Auxin_inducible PF02519.14 CDI77812.1 - 1.2 9.3 6.0 2.2 8.5 1.9 3.0 1 1 1 2 2 2 0 Auxin responsive protein Sec7 PF01369.20 CDI77813.1 - 4.6e-46 156.8 0.0 6.7e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain RabGAP-TBC PF00566.18 CDI77813.1 - 2.7e-33 115.5 0.9 2.1e-32 112.5 1.0 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Sulfate_transp PF00916.20 CDI77814.1 - 1.9e-66 224.4 16.6 3.5e-35 121.5 4.9 2.2 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 CDI77814.1 - 2.8e-17 62.4 0.0 4.5e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CDI77814.1 - 0.013 15.8 0.0 0.039 14.3 0.0 1.9 1 0 0 1 1 1 0 STAS domain UL41A PF17591.2 CDI77814.1 - 0.29 11.2 2.8 3.8 7.7 0.0 3.5 3 0 0 3 3 3 0 Herpesvirus UL41A zf-MIZ PF02891.20 CDI77815.1 - 4.9e-17 61.4 3.7 1.9e-16 59.5 3.7 2.1 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 CDI77815.1 - 1.1e-08 34.6 0.0 2.1e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 SAP domain PHD_2 PF13831.6 CDI77815.1 - 0.0078 15.7 0.1 0.0078 15.7 0.1 2.9 3 1 0 3 3 3 1 PHD-finger PHD PF00628.29 CDI77815.1 - 0.16 11.9 12.0 0.65 9.9 2.5 3.2 2 1 0 2 2 2 0 PHD-finger Bro-N PF02498.17 CDI77815.1 - 5.5 7.7 6.7 1.2 9.9 1.3 2.8 2 0 0 2 2 2 0 BRO family, N-terminal domain OmpH PF03938.14 CDI77817.1 - 0.00088 19.6 7.4 0.00088 19.6 7.4 1.8 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Apolipoprotein PF01442.18 CDI77817.1 - 0.0015 18.5 8.5 0.0026 17.7 8.5 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 CDI77817.1 - 0.0036 16.9 3.8 0.0042 16.7 3.8 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF4763 PF15960.5 CDI77817.1 - 0.025 13.9 13.1 0.041 13.2 13.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Prominin PF05478.11 CDI77817.1 - 0.053 11.5 0.9 0.066 11.2 0.9 1.1 1 0 0 1 1 1 0 Prominin Mitofilin PF09731.9 CDI77817.1 - 0.097 11.5 10.7 0.13 11.1 10.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Spc7 PF08317.11 CDI77817.1 - 0.11 11.3 6.7 0.16 10.8 6.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FapA PF03961.13 CDI77817.1 - 0.26 9.9 2.1 0.34 9.5 2.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SKIP_SNW PF02731.15 CDI77817.1 - 0.34 10.6 5.5 0.62 9.7 4.9 1.7 1 1 1 2 2 2 0 SKIP/SNW domain YlqD PF11068.8 CDI77817.1 - 1.1 9.6 12.4 2.4 8.5 12.4 1.6 1 0 0 1 1 1 0 YlqD protein SKA2 PF16740.5 CDI77817.1 - 1.5 8.6 12.4 2.2 8.1 10.6 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 ATP-synt_B PF00430.18 CDI77817.1 - 7.4 6.7 10.7 1.4 9.0 6.5 1.9 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Aminotran_1_2 PF00155.21 CDI77817.1 - 8 5.5 5.6 15 4.6 4.1 1.9 1 1 1 2 2 2 0 Aminotransferase class I and II Nop PF01798.18 CDI77818.1 - 3.1e-51 174.1 0.6 7e-51 172.9 0.2 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CDI77818.1 - 6.1e-16 59.4 6.2 9.9e-16 58.8 4.7 2.2 2 0 0 2 2 2 1 Prp31 C terminal domain DUF1053 PF06327.14 CDI77818.1 - 1.5 9.4 3.7 7.3 7.2 0.3 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1053) DUF515 PF04415.12 CDI77819.1 - 9.2 4.5 19.8 4.7 5.5 9.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF515) TFIIA PF03153.13 CDI77821.1 - 7.7 6.4 22.1 9.4 6.1 22.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4647 PF15504.6 CDI77821.1 - 8.5 5.4 23.2 9.7 5.2 23.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF2076 PF09849.9 CDI77822.1 - 0.0025 17.9 32.5 0.0025 17.9 32.5 7.0 5 1 3 8 8 8 1 Uncharacterized protein conserved in bacteria (DUF2076) Plasmodium_Vir PF05795.11 CDI77823.1 - 0.027 13.9 9.0 0.034 13.6 9.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein BUD22 PF09073.10 CDI77823.1 - 0.036 13.4 20.7 0.053 12.9 20.7 1.2 1 0 0 1 1 1 0 BUD22 EF-1_beta_acid PF10587.9 CDI77823.1 - 0.063 13.7 4.0 0.063 13.7 4.0 3.5 4 1 0 4 4 4 0 Eukaryotic elongation factor 1 beta central acidic region DUF572 PF04502.13 CDI77823.1 - 0.11 12.1 20.1 0.15 11.7 20.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Med15 PF09606.10 CDI77823.1 - 0.11 11.1 30.3 0.13 10.9 30.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI77823.1 - 0.26 11.3 31.5 0.45 10.4 31.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI77823.1 - 3 7.2 8.2 4.7 6.5 8.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HemX PF04375.14 CDI77823.1 - 6 6.1 31.1 12 5.1 31.1 1.5 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Nop25 PF09805.9 CDI77824.1 - 0.021 15.3 3.2 0.023 15.2 3.2 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Menin PF05053.13 CDI77824.1 - 5 5.4 16.5 6.9 4.9 16.5 1.3 1 0 0 1 1 1 0 Menin WD40 PF00400.32 CDI77825.1 - 4.6e-17 62.1 1.2 0.00069 20.4 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat Prp19 PF08606.11 CDI77825.1 - 3.7e-13 49.3 4.7 6.9e-13 48.4 4.7 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 CDI77825.1 - 1.1e-05 25.6 0.0 0.062 13.6 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1635 PF07795.11 CDI77825.1 - 0.00081 19.3 4.0 0.0015 18.4 4.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1635) TBCA PF02970.16 CDI77825.1 - 0.036 14.4 0.2 0.069 13.5 0.2 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A Det1 PF09737.9 CDI77825.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 De-etiolated protein 1 Det1 PPC PF04151.15 CDI77825.1 - 0.14 13.3 0.6 0.14 13.3 0.6 2.3 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain SSP160 PF06933.11 CDI77826.1 - 1.1e-06 27.2 18.2 1.1e-06 27.2 18.2 3.2 3 0 0 3 3 3 2 Special lobe-specific silk protein SSP160 PAT1 PF09770.9 CDI77826.1 - 0.097 10.9 32.7 0.13 10.6 32.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Utp14 PF04615.13 CDI77826.1 - 0.66 8.5 22.1 1.3 7.5 22.1 1.5 1 0 0 1 1 1 0 Utp14 protein DUF4770 PF15994.5 CDI77826.1 - 0.71 10.1 21.7 0.19 12.0 10.7 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) Pinin_SDK_memA PF04696.13 CDI77826.1 - 1.6 8.8 33.7 0.42 10.7 24.3 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region DUF1764 PF08576.10 CDI77826.1 - 3.3 8.7 19.2 12 6.8 11.2 4.0 4 0 0 4 4 4 0 Eukaryotic protein of unknown function (DUF1764) Peptidase_S49_N PF08496.10 CDI77826.1 - 7 6.7 13.7 10 6.1 11.1 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Connexin PF00029.19 CDI77826.1 - 7.1 6.3 13.4 4.1 7.1 9.3 2.4 3 0 0 3 3 3 0 Connexin MAS20 PF02064.15 CDI77826.1 - 7.6 6.6 32.1 0.28 11.3 0.6 3.3 3 0 0 3 3 3 0 MAS20 protein import receptor D123 PF07065.14 CDI77826.1 - 8.8 5.4 23.1 0.62 9.2 10.9 3.2 3 0 0 3 3 3 0 D123 ubiquitin PF00240.23 CDI77828.1 - 6.1e-42 141.2 1.2 7.3e-35 118.6 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 CDI77828.1 - 7.8e-19 67.3 0.3 9.7e-17 60.6 0.4 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDI77828.1 - 2e-07 31.3 0.2 1.4e-05 25.4 0.1 2.7 2 1 0 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDI77828.1 - 0.0017 18.2 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 CDI77828.1 - 0.0022 18.0 0.7 4.3 7.5 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 CDI77828.1 - 0.0028 18.0 0.1 0.0033 17.8 0.1 1.3 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDI77828.1 - 0.0033 17.5 0.0 0.01 16.0 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Sde2_N_Ubi PF13019.6 CDI77828.1 - 0.032 14.1 0.1 0.29 11.0 0.0 1.9 1 1 1 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain DUF2407 PF10302.9 CDI77828.1 - 0.039 14.5 0.0 0.054 14.0 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain HMG_box PF00505.19 CDI77829.1 - 2.2e-14 53.6 2.8 6.6e-14 52.1 2.8 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDI77829.1 - 2.4e-05 24.9 2.6 0.00011 22.7 2.6 2.2 1 0 0 1 1 1 1 HMG-box domain MASE4 PF17158.4 CDI77831.1 - 0.054 12.8 0.4 0.27 10.5 0.4 2.2 1 0 0 1 1 1 0 Membrane-associated sensor, integral membrane domain SARAF PF06682.12 CDI77832.1 - 9.6 5.7 60.5 1.6 8.3 9.2 3.5 3 1 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis SLIDE PF09111.10 CDI77834.1 - 9.4e-11 41.7 0.0 2.2e-10 40.5 0.0 1.6 2 0 0 2 2 2 1 SLIDE gerPA PF10676.9 CDI77834.1 - 1.3 9.3 6.8 0.79 10.0 3.6 2.4 1 1 1 2 2 2 0 Spore germination protein gerPA/gerPF SOBP PF15279.6 CDI77834.1 - 5.5 7.5 12.2 8.8 6.8 12.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Macoilin PF09726.9 CDI77834.1 - 8.6 4.8 7.5 15 4.0 7.5 1.4 1 0 0 1 1 1 0 Macoilin family SNF2_N PF00176.23 CDI77835.1 - 7.6e-56 189.3 2.1 7.6e-56 189.3 2.1 2.8 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 CDI77835.1 - 5.1e-08 33.1 2.1 5.1e-08 33.1 2.1 3.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDI77835.1 - 4.2e-06 27.1 0.0 2.7e-05 24.5 0.0 2.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_11 PF13086.6 CDI77835.1 - 6.6e-05 22.8 5.8 6.6e-05 22.8 5.8 4.1 3 1 0 3 3 3 1 AAA domain Presenilin PF01080.17 CDI77835.1 - 0.00017 20.5 16.9 0.00017 20.5 16.9 3.1 3 0 0 3 3 3 1 Presenilin TFIIA PF03153.13 CDI77835.1 - 0.018 15.1 68.6 0.032 14.2 25.3 3.3 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit DUF2052 PF09747.9 CDI77835.1 - 0.049 13.7 57.3 0.021 14.9 20.0 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) DDHD PF02862.17 CDI77835.1 - 0.067 13.3 27.6 0.35 11.0 1.4 3.5 3 0 0 3 3 3 0 DDHD domain PDEase_I PF00233.19 CDI77836.1 - 1.8e-63 214.4 0.3 2.2e-63 214.2 0.3 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 CDI77836.1 - 0.058 13.6 0.8 0.15 12.3 0.8 2.0 1 1 0 1 1 1 0 HD domain Glutaredoxin PF00462.24 CDI77838.1 - 1.8e-17 63.3 0.0 4.8e-17 61.9 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin PCI PF01399.27 CDI77840.1 - 5.3e-22 78.3 0.1 1.8e-21 76.6 0.1 2.0 1 0 0 1 1 1 1 PCI domain Rpn3_C PF08375.11 CDI77840.1 - 1.4e-11 44.6 0.1 1.4e-11 44.6 0.1 4.2 3 1 1 4 4 4 2 Proteasome regulatory subunit C-terminal RskA PF10099.9 CDI77840.1 - 3.7e-05 24.1 7.3 0.19 12.0 4.1 2.8 1 1 1 2 2 2 2 Anti-sigma-K factor rskA Secretin_N_2 PF07655.13 CDI77840.1 - 0.002 18.7 1.2 0.002 18.7 1.2 3.7 3 1 1 4 4 4 1 Secretin N-terminal domain Pox_J1 PF03338.15 CDI77840.1 - 0.061 13.2 0.1 0.59 10.0 0.0 2.3 2 0 0 2 2 2 0 Poxvirus J1 protein TPR_2 PF07719.17 CDI77840.1 - 0.16 12.2 1.9 1 9.6 1.9 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2433 PF10360.9 CDI77840.1 - 0.34 11.0 3.1 0.36 10.9 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2433) DUF3446 PF11928.8 CDI77841.1 - 3.1 8.2 6.5 19 5.7 4.1 2.9 2 1 0 2 2 2 0 Early growth response N-terminal domain DUF2722 PF10846.8 CDI77842.1 - 0.0028 16.7 3.9 0.0028 16.7 3.9 9.2 7 3 1 9 9 9 2 Protein of unknown function (DUF2722) RAP1 PF07218.11 CDI77842.1 - 4.4 5.5 5.4 7.8 4.6 5.4 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RsgA_GTPase PF03193.16 CDI77843.1 - 0.00014 21.9 0.1 0.0004 20.3 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CDI77843.1 - 0.00089 19.7 0.3 0.0018 18.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDI77843.1 - 0.017 15.4 0.0 0.049 13.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CDI77843.1 - 0.021 14.7 0.1 0.033 14.1 0.1 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 CDI77843.1 - 0.041 13.6 0.8 0.082 12.6 0.1 1.7 1 1 1 2 2 2 0 AAA domain NACHT PF05729.12 CDI77843.1 - 0.046 13.6 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 CDI77843.1 - 0.051 14.1 0.0 0.082 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDI77843.1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNase_H PF00075.24 CDI77844.1 - 2.2e-29 102.5 0.6 2.9e-26 92.4 0.6 3.0 1 1 0 1 1 1 1 RNase H Ribosomal_60s PF00428.19 CDI77844.1 - 0.2 12.3 29.8 0.24 12.0 9.3 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein CbiD PF01888.17 CDI77844.1 - 3.5 6.8 10.2 21 4.3 10.0 2.0 1 1 1 2 2 2 0 CbiD Rotamase_2 PF13145.6 CDI77844.1 - 6.9 7.5 10.7 2 9.2 2.6 2.2 2 0 0 2 2 2 0 PPIC-type PPIASE domain Beta-Casp PF10996.8 CDI77849.1 - 1.3e-20 73.7 0.0 9.2e-20 71.0 0.0 2.4 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 CDI77849.1 - 3.2e-18 65.4 0.0 7.6e-18 64.2 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain CPSF73-100_C PF11718.8 CDI77849.1 - 1.1e-07 31.7 2.1 1.1e-07 31.7 2.1 2.8 2 1 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_6 PF16661.5 CDI77849.1 - 9.3e-05 21.9 0.0 0.00022 20.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 CDI77849.1 - 0.00014 21.2 0.0 0.00028 20.2 0.0 1.4 1 0 0 1 1 1 1 Putative beta-lactamase-like family DRMBL PF07522.14 CDI77849.1 - 0.0015 18.7 0.0 0.0042 17.2 0.0 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Peptidase_S64 PF08192.11 CDI77849.1 - 7.7 4.9 14.0 0.35 9.3 3.8 2.1 2 0 0 2 2 2 0 Peptidase family S64 SAC3_GANP PF03399.16 CDI77850.1 - 2.5e-10 40.2 7.6 2.5e-10 40.2 7.6 4.3 4 1 0 4 4 4 1 SAC3/GANP family RskA PF10099.9 CDI77851.1 - 0.0017 18.7 21.1 0.0017 18.7 21.1 6.7 3 2 2 5 5 5 2 Anti-sigma-K factor rskA Zip PF02535.22 CDI77851.1 - 0.0061 15.8 4.8 0.0061 15.8 4.8 3.2 3 0 0 3 3 3 2 ZIP Zinc transporter SAGA-Tad1 PF12767.7 CDI77851.1 - 1 9.1 46.5 0.08 12.7 12.6 3.3 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit SLC12 PF03522.15 CDI77851.1 - 5.9 5.8 51.4 0.045 12.8 18.3 3.2 3 0 0 3 3 3 0 Solute carrier family 12 RskA PF10099.9 CDI77852.1 - 0.0076 16.6 6.9 0.0076 16.6 6.9 14.5 4 3 3 8 8 8 3 Anti-sigma-K factor rskA K_channel_TID PF07941.11 CDI77853.1 - 0.017 15.6 2.0 0.017 15.6 2.0 6.1 3 2 2 5 5 5 0 Potassium channel Kv1.4 tandem inactivation domain Peptidase_C48 PF02902.19 CDI77854.1 - 5.2e-33 114.7 0.0 9.6e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF2722 PF10846.8 CDI77854.1 - 0.04 12.9 4.9 0.075 12.0 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI77854.1 - 0.12 11.3 16.3 0.096 11.6 12.4 2.1 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Sipho_Gp157 PF05565.11 CDI77855.1 - 0.0054 16.8 0.1 0.0086 16.1 0.1 1.3 1 0 0 1 1 1 1 Siphovirus Gp157 TMF_DNA_bd PF12329.8 CDI77855.1 - 0.073 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding LST1 PF05083.13 CDI77855.1 - 0.087 13.1 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 LST-1 protein DUF1635 PF07795.11 CDI77856.1 - 0.21 11.4 4.5 0.52 10.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) PDEase_I PF00233.19 CDI77857.1 - 5.1e-23 82.0 1.1 5.1e-22 78.8 0.0 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase DUF3907 PF13047.6 CDI77857.1 - 0.026 14.5 0.2 0.04 13.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) TFIIA PF03153.13 CDI77857.1 - 0.63 10.0 23.7 0.75 9.7 23.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OmpH PF03938.14 CDI77857.1 - 0.67 10.3 14.7 1.1 9.7 14.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DDHD PF02862.17 CDI77857.1 - 3.1 7.9 10.7 4.3 7.4 10.7 1.2 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 CDI77857.1 - 3.3 7.7 5.7 4.4 7.3 5.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI77857.1 - 8.1 5.2 10.5 9.3 4.9 10.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SUIM_assoc PF16619.5 CDI77858.1 - 5.1e-05 23.3 22.5 0.0046 17.0 1.8 3.6 3 0 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 STAC2_u1 PF16664.5 CDI77858.1 - 0.037 14.5 2.5 0.04 14.4 0.3 2.1 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF2722 PF10846.8 CDI77858.1 - 3.9 6.3 17.4 0.071 12.0 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Suf PF05843.14 CDI77858.1 - 4.8 7.1 11.3 0.28 11.1 0.3 2.8 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) RskA PF10099.9 CDI77858.1 - 6.8 6.9 26.7 0.066 13.5 7.3 3.3 2 1 1 3 3 3 0 Anti-sigma-K factor rskA GTP_EFTU PF00009.27 CDI77859.1 - 2.4e-23 82.7 0.1 2.9e-22 79.2 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.11 CDI77859.1 - 1e-17 64.2 0.3 2.7e-17 62.8 0.0 1.8 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 CDI77859.1 - 4.3e-11 43.0 1.7 5.4e-11 42.7 0.3 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDI77859.1 - 0.0046 17.0 0.0 0.0089 16.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI77859.1 - 0.036 14.0 0.2 0.21 11.4 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase SpoIIP PF07454.11 CDI77860.1 - 5.3 6.4 28.5 0.82 9.1 7.5 4.2 4 0 0 4 4 4 0 Stage II sporulation protein P (SpoIIP) Methyltransf_25 PF13649.6 CDI77861.1 - 0.11 13.2 3.6 0.46 11.2 0.1 3.6 3 1 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDI77861.1 - 0.55 11.0 0.0 0.55 11.0 0.0 3.2 4 0 0 4 4 4 0 Methyltransferase domain RRM_1 PF00076.22 CDI77862.1 - 1.2e-17 63.5 0.0 2.4e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI77862.1 - 0.003 17.5 0.0 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 CDI77862.1 - 0.0087 15.7 0.0 0.27 10.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Radical_SAM PF04055.21 CDI77863.1 - 5.9e-08 33.3 0.4 2.9e-06 27.8 0.4 3.0 1 1 1 2 2 2 1 Radical SAM superfamily PAT1 PF09770.9 CDI77863.1 - 0.0022 16.4 32.6 0.0022 16.4 32.6 3.6 3 1 0 3 3 3 1 Topoisomerase II-associated protein PAT1 HemN_C PF06969.16 CDI77863.1 - 0.003 17.6 1.4 0.011 15.8 0.0 2.8 2 0 0 2 2 2 1 HemN C-terminal domain RskA PF10099.9 CDI77863.1 - 0.0057 17.0 0.0 0.0057 17.0 0.0 6.8 4 3 1 5 5 5 3 Anti-sigma-K factor rskA BUD22 PF09073.10 CDI77863.1 - 0.0068 15.8 33.7 0.0071 15.7 6.4 3.4 3 0 0 3 3 3 2 BUD22 Ribosomal_60s PF00428.19 CDI77863.1 - 0.019 15.6 3.3 0.019 15.6 3.3 7.8 6 1 0 6 6 6 0 60s Acidic ribosomal protein Lin-8 PF03353.15 CDI77863.1 - 0.15 11.6 69.4 0.025 14.1 15.7 4.2 4 0 0 4 4 4 0 Ras-mediated vulval-induction antagonist Peptidase_S64 PF08192.11 CDI77863.1 - 0.47 8.9 50.9 0.12 10.9 16.2 3.3 3 0 0 3 3 3 0 Peptidase family S64 SID-1_RNA_chan PF13965.6 CDI77863.1 - 9.5 4.5 21.6 0.29 9.5 6.0 3.1 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 Ribosomal_L3 PF00297.22 CDI77864.1 - 3e-173 576.0 3.5 3.4e-173 575.8 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 SGS PF05002.15 CDI77865.1 - 1.4e-28 98.8 0.6 1.4e-28 98.8 0.6 1.8 2 0 0 2 2 2 1 SGS domain CS PF04969.16 CDI77865.1 - 7.4e-12 46.1 1.5 7.4e-12 46.1 1.5 1.5 2 0 0 2 2 2 1 CS domain Mt_ATP-synt_D PF05873.12 CDI77865.1 - 0.016 15.1 2.7 0.018 14.9 1.1 1.8 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) DUF4834 PF16118.5 CDI77866.1 - 0.00034 21.5 0.2 0.00069 20.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) GpcrRhopsn4 PF10192.9 CDI77866.1 - 0.00055 19.4 0.0 0.0009 18.7 0.0 1.3 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain RskA PF10099.9 CDI77866.1 - 0.002 18.5 1.5 0.0027 18.0 0.7 1.5 1 1 0 1 1 1 1 Anti-sigma-K factor rskA TraT PF05818.12 CDI77866.1 - 0.0025 17.6 0.3 0.0042 16.8 0.3 1.4 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein DUF2391 PF09622.10 CDI77866.1 - 0.0027 17.1 0.5 0.17 11.2 0.2 2.3 2 0 0 2 2 2 1 Putative integral membrane protein (DUF2391) FHIPEP PF00771.20 CDI77866.1 - 0.036 12.5 0.7 0.053 12.0 0.7 1.2 1 0 0 1 1 1 0 FHIPEP family Spt20 PF12090.8 CDI77866.1 - 0.079 12.6 23.1 0.12 11.9 23.1 1.2 1 0 0 1 1 1 0 Spt20 family DivIC PF04977.15 CDI77866.1 - 0.12 12.1 9.1 0.29 10.9 9.1 1.7 1 0 0 1 1 1 0 Septum formation initiator DNApol_Exo PF18136.1 CDI77866.1 - 0.16 11.1 3.4 0.25 10.5 3.4 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain SUIM_assoc PF16619.5 CDI77866.1 - 0.22 11.6 24.1 1.9e+02 2.2 24.1 2.6 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Med15 PF09606.10 CDI77866.1 - 0.25 10.0 19.7 0.38 9.4 19.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI77866.1 - 0.63 10.0 19.8 1 9.3 19.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI77866.1 - 1.2 9.1 9.2 1.7 8.6 9.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3682 PF12446.8 CDI77866.1 - 2 8.9 14.9 4.2 7.9 14.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) OATP PF03137.20 CDI77866.1 - 5.6 5.1 9.5 1.1e+02 0.8 9.5 2.0 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Exo_endo_phos PF03372.23 CDI77867.1 - 1.5e-06 27.9 0.0 4.2e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TFIIA PF03153.13 CDI77867.1 - 0.0005 20.2 44.7 0.0005 20.2 44.7 2.8 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI77867.1 - 0.23 9.9 6.3 0.27 9.7 2.6 2.0 2 0 0 2 2 2 0 FHIPEP family V_ATPase_I PF01496.19 CDI77867.1 - 7.6 4.3 14.3 15 3.4 14.3 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LRR_9 PF14580.6 CDI77868.1 - 3.1e-09 36.6 4.0 5.8e-09 35.7 4.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 CDI77868.1 - 0.0047 16.7 4.4 0.011 15.5 4.4 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 CDI77868.1 - 0.0071 16.7 7.6 0.041 14.3 1.3 2.4 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) DoxX_3 PF13781.6 CDI77868.1 - 0.056 14.1 0.4 0.056 14.1 0.4 2.3 2 0 0 2 2 2 0 DoxX-like family LRR_6 PF13516.6 CDI77868.1 - 0.49 10.6 1.7 25 5.2 0.1 2.5 2 0 0 2 2 2 0 Leucine Rich repeat PP2C PF00481.21 CDI77870.1 - 2.9e-25 89.4 1.6 1.2e-24 87.4 1.6 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C SR-25 PF10500.9 CDI77870.1 - 0.012 15.2 8.5 0.012 15.2 8.5 4.5 5 0 0 5 5 5 0 Nuclear RNA-splicing-associated protein Phostensin_N PF13916.6 CDI77871.1 - 0.03 14.6 0.6 0.03 14.6 0.6 11.2 8 2 3 11 11 11 0 PP1-regulatory protein, Phostensin N-terminal DUF4179 PF13786.6 CDI77871.1 - 4.9 7.7 30.6 1.2 9.7 0.3 6.1 6 1 0 6 6 6 0 Domain of unknown function (DUF4179) Pkinase PF00069.25 CDI77872.1 - 1.4e-20 73.8 5.6 1.4e-11 44.3 0.0 3.2 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77872.1 - 3.7e-15 55.9 2.3 4.6e-09 35.9 0.0 2.6 2 1 1 3 3 3 2 Protein tyrosine kinase DUF4834 PF16118.5 CDI77872.1 - 0.00041 21.3 13.5 0.017 16.1 0.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Sporozoite_P67 PF05642.11 CDI77872.1 - 0.0008 17.6 14.8 0.0011 17.2 14.8 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen Spt20 PF12090.8 CDI77872.1 - 0.0025 17.5 41.9 0.044 13.4 12.3 2.1 2 0 0 2 2 2 2 Spt20 family Haspin_kinase PF12330.8 CDI77872.1 - 0.0036 16.3 0.2 0.0036 16.3 0.2 2.6 3 1 0 3 3 2 1 Haspin like kinase domain Macoilin PF09726.9 CDI77872.1 - 0.008 14.8 17.5 0.012 14.2 3.4 2.1 2 0 0 2 2 2 2 Macoilin family Coilin_N PF15862.5 CDI77872.1 - 0.017 14.9 0.6 0.017 14.9 0.6 2.3 2 0 0 2 2 2 0 Coilin N-terminus MID_MedPIWI PF18296.1 CDI77872.1 - 0.029 14.1 0.5 0.029 14.1 0.5 2.4 2 0 0 2 2 2 0 MID domain of medPIWI PhdYeFM_antitox PF02604.19 CDI77872.1 - 0.036 13.9 0.0 0.036 13.9 0.0 2.2 3 0 0 3 3 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system TFIIA PF03153.13 CDI77872.1 - 0.049 13.6 40.2 0.56 10.1 19.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI77872.1 - 0.07 13.5 17.4 0.84 10.0 3.0 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like FAM60A PF15396.6 CDI77872.1 - 0.14 12.2 12.2 0.83 9.6 1.2 2.3 2 0 0 2 2 2 0 Protein Family FAM60A U1snRNP70_N PF12220.8 CDI77872.1 - 0.2 12.3 8.3 1.4 9.6 0.3 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SpoIIP PF07454.11 CDI77872.1 - 0.34 10.3 14.2 0.48 9.8 1.3 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI77872.1 - 0.39 9.7 13.6 1.5 7.7 1.1 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Band_3_cyto PF07565.13 CDI77872.1 - 0.49 10.1 15.7 0.31 10.8 0.9 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CTU2 PF10288.9 CDI77872.1 - 0.51 10.6 20.1 0.44 10.8 1.7 2.5 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Spore_III_AF PF09581.10 CDI77872.1 - 0.54 10.3 9.2 1.9 8.5 1.6 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) Neur_chan_memb PF02932.16 CDI77872.1 - 0.54 10.3 13.0 1.7 8.6 0.5 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4820 PF16091.5 CDI77872.1 - 0.61 9.4 15.8 0.36 10.2 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) EOS1 PF12326.8 CDI77872.1 - 0.7 9.8 7.8 2.7 7.9 0.5 2.3 2 0 0 2 2 2 0 N-glycosylation protein RLL PF10036.9 CDI77872.1 - 0.75 9.6 16.5 2 8.2 2.4 2.2 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein SURF2 PF05477.11 CDI77872.1 - 0.81 9.3 13.2 0.35 10.5 4.3 2.1 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Apt1 PF10351.9 CDI77872.1 - 0.88 8.3 16.4 0.62 8.9 2.2 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF3807 PF12720.7 CDI77872.1 - 1 9.6 24.0 2.2 8.5 4.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) SPX PF03105.19 CDI77872.1 - 1.3 8.9 25.8 0.053 13.4 7.9 2.1 2 0 0 2 2 2 0 SPX domain Ctr PF04145.15 CDI77872.1 - 1.3 9.6 9.9 2.5 8.7 0.5 2.4 2 0 0 2 2 2 0 Ctr copper transporter family RIFIN PF02009.16 CDI77872.1 - 1.6 8.6 15.2 8.8 6.1 0.1 2.1 2 0 0 2 2 2 0 Rifin Eapp_C PF10238.9 CDI77872.1 - 1.6 8.8 17.1 0.91 9.6 1.3 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein BAF1_ABF1 PF04684.13 CDI77872.1 - 1.9 7.4 21.6 0.52 9.3 1.9 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor CPSF100_C PF13299.6 CDI77872.1 - 1.9 8.6 17.8 1.4 9.0 1.7 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 CDI77872.1 - 2 7.3 13.3 0.59 9.0 0.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Baculo_PP31 PF05311.11 CDI77872.1 - 2.2 7.7 13.9 0.41 10.1 1.2 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Peroxin-13_N PF04088.13 CDI77872.1 - 2.2 8.5 6.3 6 7.1 0.1 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region DUF2052 PF09747.9 CDI77872.1 - 2.2 8.3 15.8 5.6 7.0 1.7 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Rxt3 PF08642.10 CDI77872.1 - 3.2 8.5 9.3 9.3 7.0 0.9 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF572 PF04502.13 CDI77872.1 - 3.5 7.2 17.6 1.6 8.3 1.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) NST1 PF13945.6 CDI77872.1 - 3.7 7.6 26.5 3.3 7.8 13.4 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator Spem1 PF15670.5 CDI77872.1 - 3.8 7.0 12.5 1.7 8.2 0.9 2.4 2 0 0 2 2 2 0 Spermatid maturation protein 1 Gti1_Pac2 PF09729.9 CDI77872.1 - 4.3 7.4 17.1 1.8 8.6 1.3 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family TERB2 PF15101.6 CDI77872.1 - 5.2 7.1 25.7 6.9 6.7 11.9 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 APH PF01636.23 CDI77872.1 - 6 6.7 12.0 0.24 11.3 5.0 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family EFTUD2 PF16004.5 CDI77872.1 - 8.2 7.0 18.9 3.3 8.3 4.9 2.3 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF1645 PF07816.11 CDI77872.1 - 9.7 6.7 22.5 3.7 8.1 6.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Mitofilin PF09731.9 CDI77872.1 - 10 4.8 27.6 6.8 5.4 15.1 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein BLOC1_2 PF10046.9 CDI77873.1 - 1.7 9.0 21.1 0.047 14.0 4.1 3.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Hydrolase_4 PF12146.8 CDI77875.1 - 0.0012 18.2 0.0 0.4 9.9 0.0 3.2 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI77875.1 - 0.015 15.0 0.6 0.15 11.7 0.0 2.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 CDI77875.1 - 0.052 13.4 0.0 0.052 13.4 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 3) Cpn10 PF00166.21 CDI77882.1 - 2.7e-43 145.9 0.6 6.4e-21 74.2 0.1 2.1 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit Cupin_3 PF05899.12 CDI77882.1 - 0.013 15.2 0.1 0.77 9.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Na_H_Exchanger PF00999.21 CDI77883.1 - 3.5e-45 154.4 39.8 5.5e-45 153.8 39.8 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RIFIN PF02009.16 CDI77883.1 - 0.65 9.8 0.0 0.65 9.8 0.0 2.3 1 1 1 2 2 2 0 Rifin Apt1 PF10351.9 CDI77883.1 - 1.1 8.1 17.0 0.054 12.4 8.0 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain TFIIA PF03153.13 CDI77883.1 - 3.7 7.4 30.0 0.63 10.0 16.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI77883.1 - 4.7 5.7 19.2 0.053 12.1 8.2 2.4 2 0 0 2 2 2 0 Macoilin family Presenilin PF01080.17 CDI77883.1 - 7.8 5.1 16.2 0.27 10.0 1.4 2.8 3 0 0 3 3 3 0 Presenilin PAXIP1_C PF15364.6 CDI77884.1 - 0.047 14.0 0.0 0.066 13.5 0.0 1.2 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein RSN1_TM PF13967.6 CDI77884.1 - 0.048 13.4 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport MFS_1 PF07690.16 CDI77884.1 - 0.083 11.8 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF3357 PF11837.8 CDI77884.1 - 0.2 12.2 0.2 0.47 10.9 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Apt1 PF10351.9 CDI77886.1 - 4.7 5.9 19.3 3.5 6.4 8.7 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain HrpB1_HrpK PF09613.10 CDI77888.1 - 0.0018 17.9 0.0 0.96 9.1 0.1 2.3 2 0 0 2 2 2 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_14 PF13428.6 CDI77888.1 - 0.014 16.1 1.7 3.3 8.8 0.3 3.1 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDI77888.1 - 0.043 14.4 5.6 0.47 11.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC2_membrane_2 PF12679.7 CDI77891.1 - 0.047 13.0 0.0 1.2 8.4 0.0 2.9 2 1 0 2 2 2 0 ABC-2 family transporter protein Tmem26 PF09772.9 CDI77891.1 - 0.34 10.2 6.2 0.71 9.2 6.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 26 PAT1 PF09770.9 CDI77891.1 - 0.46 8.7 31.1 0.013 13.8 18.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 CDI77891.1 - 4.1 6.3 14.7 0.12 11.3 8.2 1.6 2 0 0 2 2 2 0 Solute carrier family 12 GWT1 PF06423.12 CDI77891.1 - 5.9 7.0 6.9 1.6e+02 2.3 5.6 2.6 2 1 0 2 2 2 0 GWT1 GRIP PF01465.20 CDI77892.1 - 8e-12 44.9 0.9 8e-12 44.9 0.9 2.7 2 0 0 2 2 2 1 GRIP domain PRIMA1 PF16101.5 CDI77892.1 - 0.96 9.5 5.9 3.2 7.8 5.9 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Stk19 PF10494.9 CDI77893.1 - 5.5e-06 26.2 0.3 5.5e-06 26.2 0.3 3.2 3 1 0 3 3 3 1 Serine-threonine protein kinase 19 DUF755 PF05501.11 CDI77893.1 - 0.0011 19.3 21.2 0.0011 19.3 21.2 8.0 6 3 3 9 9 9 2 Domain of unknown function (DUF755) RskA PF10099.9 CDI77893.1 - 0.027 14.7 0.6 0.027 14.7 0.6 8.1 5 3 2 7 7 7 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI77893.1 - 2.4 8.3 0.0 2.4 8.3 0.0 12.5 6 2 3 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 DUF1645 PF07816.11 CDI77895.1 - 0.011 16.3 0.2 0.011 16.3 0.2 6.1 5 1 0 5 5 5 0 Protein of unknown function (DUF1645) DUF3112 PF11309.8 CDI77895.1 - 0.26 10.7 0.2 0.61 9.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) EcKinase PF02958.20 CDI77895.1 - 2.8 7.2 5.5 0.22 10.8 0.4 1.7 2 0 0 2 2 2 0 Ecdysteroid kinase ESM4 PF15952.5 CDI77895.1 - 3.4 8.0 11.2 0.044 14.2 1.6 2.6 3 0 0 3 3 3 0 Enhancer of split M4 family Lip_prot_lig_C PF10437.9 CDI77896.1 - 0.00014 21.7 0.0 0.00043 20.2 0.0 1.8 2 0 0 2 2 2 1 Bacterial lipoate protein ligase C-terminus Androgen_recep PF02166.16 CDI77896.1 - 5.4 5.7 6.5 8.3 5.1 6.5 1.2 1 0 0 1 1 1 0 Androgen receptor SR-25 PF10500.9 CDI77897.1 - 0.00021 21.0 9.1 0.00021 21.0 9.1 3.5 2 1 2 4 4 4 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI77897.1 - 0.014 15.7 13.5 0.014 15.7 13.5 4.0 3 1 1 4 4 4 0 Anti-sigma-K factor rskA FAM76 PF16046.5 CDI77897.1 - 0.089 12.1 38.1 0.33 10.3 12.5 2.2 2 0 0 2 2 2 0 FAM76 protein YdjM PF04307.14 CDI77897.1 - 0.2 11.0 0.0 0.44 9.8 0.0 1.5 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase RskA PF10099.9 CDI77899.1 - 3.9e-05 24.0 0.4 3.9e-05 24.0 0.4 9.1 2 1 5 7 7 7 2 Anti-sigma-K factor rskA Adaptin_binding PF10199.9 CDI77899.1 - 0.17 12.5 0.0 0.17 12.5 0.0 7.5 3 3 2 5 5 5 0 Alpha and gamma adaptin binding protein p34 Pkinase_Tyr PF07714.17 CDI77900.1 - 0.00036 19.9 0.1 0.00064 19.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDI77900.1 - 0.0021 17.5 0.0 0.0026 17.2 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain MdcG PF10620.9 CDI77900.1 - 0.12 12.2 2.3 0.3 10.9 2.3 1.8 1 1 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG TEX13 PF15186.6 CDI77900.1 - 0.81 9.4 6.0 1.2 8.9 6.0 1.3 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family TLP-20 PF06088.11 CDI77901.1 - 0.0061 16.5 11.3 0.012 15.5 11.3 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) SLC12 PF03522.15 CDI77901.1 - 0.11 11.5 9.5 0.12 11.4 9.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sporozoite_P67 PF05642.11 CDI77901.1 - 0.17 9.9 12.1 0.19 9.8 12.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 CDI77901.1 - 0.24 10.7 19.6 0.33 10.2 19.6 1.2 1 0 0 1 1 1 0 NOA36 protein FmiP_Thoc5 PF09766.9 CDI77901.1 - 0.26 10.5 15.7 0.36 10.1 15.7 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Vfa1 PF08432.10 CDI77901.1 - 0.44 10.8 17.7 0.57 10.5 17.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 CDI77901.1 - 0.99 7.6 23.6 1.2 7.4 23.6 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI77901.1 - 1.7 8.4 15.7 2 8.2 15.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI77901.1 - 1.7 8.6 12.4 2.3 8.2 12.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DNA_pol_phi PF04931.13 CDI77901.1 - 3.4 5.7 21.1 3.4 5.7 21.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 CDI77901.1 - 4.1 6.5 11.0 5.8 6.0 11.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF913 PF06025.12 CDI77901.1 - 7.3 5.5 9.2 8.9 5.2 9.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 CDI77901.1 - 7.5 5.7 12.9 8.1 5.6 12.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MFS_1 PF07690.16 CDI77902.1 - 4.3e-10 39.1 21.9 1.2e-07 31.0 24.0 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily EMC3_TMCO1 PF01956.16 CDI77902.1 - 0.04 13.6 0.7 0.58 9.9 0.0 2.4 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Carb_anhydrase PF00194.21 CDI77903.1 - 6.8e-22 78.2 2.4 1.4e-13 51.0 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic-type carbonic anhydrase SMC_ScpB PF04079.16 CDI77903.1 - 0.013 15.2 0.0 0.039 13.6 0.0 1.7 2 0 0 2 2 2 0 Segregation and condensation complex subunit ScpB Cytochrome_C7 PF14522.6 CDI77904.1 - 8.6 6.4 8.8 2.6 8.1 0.1 3.6 2 1 1 3 3 3 0 Cytochrome c7 and related cytochrome c Rep_fac-A_3 PF08661.11 CDI77905.1 - 1.7e-09 38.0 0.0 1.9e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 DUF150_C PF17384.2 CDI77905.1 - 0.034 14.3 1.0 0.38 10.9 0.1 2.2 2 0 0 2 2 2 0 RimP C-terminal SH3 domain tRNA_Me_trans PF03054.16 CDI77906.1 - 2.1e-76 257.0 0.0 7.5e-69 232.2 0.0 2.6 2 1 0 2 2 2 2 tRNA methyl transferase SufE PF02657.15 CDI77906.1 - 0.016 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 Fe-S metabolism associated domain ThiI PF02568.14 CDI77906.1 - 0.022 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Glyco_hydro_9 PF00759.19 CDI77906.1 - 1.1 8.6 3.2 2.6 7.4 3.2 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 UPF0176_N PF17773.1 CDI77907.1 - 1.6e-19 70.1 0.0 3.6e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Methyltransf_3 PF01596.17 CDI77907.1 - 5.3e-19 68.2 0.0 1.9e-10 40.3 0.0 3.0 2 1 0 2 2 2 2 O-methyltransferase Rhodanese PF00581.20 CDI77907.1 - 1.6e-10 41.4 0.0 3.4e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_24 PF13578.6 CDI77907.1 - 1.8e-07 32.1 0.0 5.8e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain RCC1_2 PF13540.6 CDI77909.1 - 6.8e-06 25.7 7.9 0.67 9.8 0.1 5.2 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat DUF2722 PF10846.8 CDI77909.1 - 0.0007 18.7 10.9 0.019 14.0 10.9 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI77909.1 - 0.012 15.8 1.9 0.02 15.0 1.9 1.4 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CDI77909.1 - 0.013 14.3 6.8 0.017 13.9 6.8 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI77909.1 - 0.039 13.2 2.9 0.049 12.8 2.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 CDI77909.1 - 0.15 10.6 6.0 0.2 10.2 6.0 1.1 1 0 0 1 1 1 0 Macoilin family Pex14_N PF04695.13 CDI77909.1 - 0.19 12.4 13.6 0.43 11.2 13.6 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MDM10 PF12519.8 CDI77909.1 - 0.34 9.7 7.6 0.6 8.9 7.6 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TERB2 PF15101.6 CDI77909.1 - 0.42 10.6 14.4 0.71 9.9 14.4 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TFIIA PF03153.13 CDI77909.1 - 1.7 8.6 27.0 2.6 7.9 27.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Gti1_Pac2 PF09729.9 CDI77909.1 - 4.5 7.3 10.2 9 6.3 10.2 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family PAT1 PF09770.9 CDI77909.1 - 5.3 5.2 19.4 8 4.6 19.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RCC1 PF00415.18 CDI77909.1 - 5.9 7.6 6.3 33 5.2 0.7 3.3 3 0 0 3 3 2 0 Regulator of chromosome condensation (RCC1) repeat EPL1 PF10513.9 CDI77909.1 - 6.5 7.1 13.4 11 6.4 13.4 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Connexin PF00029.19 CDI77909.1 - 7 6.3 10.5 9.9 5.8 10.5 1.2 1 0 0 1 1 1 0 Connexin Borrelia_P83 PF05262.11 CDI77909.1 - 7.3 5.0 18.6 10 4.5 18.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SLC12 PF03522.15 CDI77909.1 - 9.7 5.1 11.7 13 4.6 11.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sporozoite_P67 PF05642.11 CDI77911.1 - 0.00024 19.4 12.5 0.00024 19.4 12.5 12.3 4 3 1 7 7 7 2 Sporozoite P67 surface antigen Exonuc_VII_L PF02601.15 CDI77911.1 - 0.088 12.4 0.0 0.083 12.4 21.5 13.8 9 3 1 11 11 11 0 Exonuclease VII, large subunit ANAPC1 PF12859.7 CDI77912.1 - 0.21 12.2 7.4 0.98 10.0 7.4 2.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 MAP70 PF07058.11 CDI77912.1 - 9.2 4.9 14.4 19 3.9 14.4 1.4 1 0 0 1 1 1 0 Microtubule-associated protein 70 IMP2_N PF18590.1 CDI77914.1 - 7e-17 61.8 0.0 1.8e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain DUF3584 PF12128.8 CDI77914.1 - 0.0018 15.9 4.8 0.0018 15.9 4.8 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3584) Hemagglutinin PF00509.18 CDI77914.1 - 0.073 11.5 1.2 0.12 10.7 1.2 1.2 1 0 0 1 1 1 0 Haemagglutinin Macoilin PF09726.9 CDI77914.1 - 0.14 10.6 38.4 0.16 10.5 15.0 2.3 2 0 0 2 2 2 0 Macoilin family DUF4446 PF14584.6 CDI77914.1 - 0.18 11.8 0.2 0.18 11.8 0.2 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF4446) HlyD_2 PF12700.7 CDI77914.1 - 0.61 8.8 4.2 0.087 11.5 0.2 1.5 2 0 0 2 2 2 0 HlyD family secretion protein Secretin_N_2 PF07655.13 CDI77914.1 - 1.7 9.2 28.3 0.38 11.3 12.4 3.0 3 0 0 3 3 3 0 Secretin N-terminal domain Mucin PF01456.17 CDI77915.1 - 0.00014 21.8 10.8 0.00014 21.8 10.8 4.9 3 2 0 3 3 3 1 Mucin-like glycoprotein DUF4647 PF15504.6 CDI77918.1 - 0.12 11.5 8.2 0.2 10.7 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF4834 PF16118.5 CDI77918.1 - 3.5 8.7 6.6 17 6.5 6.6 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Kazal_2 PF07648.15 CDI77919.1 - 2.8e-08 33.8 2.5 1.8e-07 31.2 2.5 2.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 CDI77919.1 - 6.9e-05 22.8 0.8 6.9e-05 22.8 0.8 2.5 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain DUF3439 PF11921.8 CDI77919.1 - 0.0017 18.3 12.6 0.0022 18.0 8.7 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) CAML PF14963.6 CDI77920.1 - 0.053 13.6 0.7 0.89 9.6 0.1 2.2 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Synaptobrevin PF00957.21 CDI77921.1 - 2.2e-20 72.2 2.1 4.1e-19 68.2 2.1 2.1 1 1 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CDI77921.1 - 1.7e-19 69.6 0.1 2.8e-19 68.9 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_UL49_5 PF05702.11 CDI77923.1 - 0.026 14.6 0.0 0.067 13.3 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL49.5 envelope/tegument protein B PF02216.16 CDI77925.1 - 0.068 13.2 2.4 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 B domain Exonuc_VII_L PF02601.15 CDI77928.1 - 0.0015 18.2 17.2 0.0016 18.1 17.2 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit MAJIN PF15077.6 CDI77928.1 - 0.081 12.7 12.0 0.11 12.2 12.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Velvet PF11754.8 CDI77928.1 - 0.094 12.6 22.1 0.17 11.8 22.1 1.4 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 CDI77928.1 - 0.11 11.9 20.8 0.15 11.5 20.8 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CCSAP PF15748.5 CDI77928.1 - 0.23 11.6 24.0 0.41 10.8 24.0 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated eIF-3_zeta PF05091.12 CDI77928.1 - 0.29 10.1 26.4 0.53 9.2 26.4 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI77928.1 - 0.73 8.5 28.1 1 8.1 28.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 CDI77928.1 - 1.8 8.1 19.2 2.8 7.5 19.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SLC12 PF03522.15 CDI77928.1 - 2 7.4 26.2 2.6 7.0 26.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Lin-8 PF03353.15 CDI77928.1 - 2.1 7.8 26.8 3.1 7.3 26.8 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDK5_activator PF03261.15 CDI77928.1 - 2.8 7.4 22.9 3.6 7.0 22.9 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein V_ATPase_I PF01496.19 CDI77928.1 - 3.6 5.4 25.9 4.5 5.1 25.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI77928.1 - 3.9 5.6 49.7 5.3 5.2 49.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FAM60A PF15396.6 CDI77928.1 - 4.1 7.4 20.8 6.3 6.7 20.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.13 CDI77928.1 - 4.7 6.9 25.2 7.7 6.2 25.2 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MMR1 PF08505.10 CDI77928.1 - 4.9 7.4 28.9 8.3 6.6 28.9 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF2052 PF09747.9 CDI77928.1 - 5.9 7.0 24.5 11 6.1 24.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Suf PF05843.14 CDI77928.1 - 7.3 6.5 32.8 13 5.6 32.8 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.12 CDI77928.1 - 8.1 6.2 24.0 15 5.3 24.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI77928.1 - 8.8 5.4 17.9 13 4.9 17.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 CDI77928.1 - 9.3 5.2 16.7 16 4.4 16.7 1.4 1 0 0 1 1 1 0 CLN3 protein Aminotran_5 PF00266.19 CDI77929.1 - 3.4e-12 46.0 7.2 0.015 14.3 0.0 5.1 5 0 0 5 5 5 4 Aminotransferase class-V ATP_bind_3 PF01171.20 CDI77929.1 - 3.3e-08 33.5 0.1 1.5e-07 31.3 0.1 2.1 1 0 0 1 1 1 1 PP-loop family SR-25 PF10500.9 CDI77929.1 - 2.4e-06 27.4 31.7 2.4e-06 27.4 31.7 10.7 10 2 1 11 11 11 3 Nuclear RNA-splicing-associated protein Suf PF05843.14 CDI77929.1 - 0.0044 17.1 3.4 0.0044 17.1 3.4 6.8 7 2 1 8 8 8 1 Suppressor of forked protein (Suf) MecA PF05389.12 CDI77929.1 - 2.6 7.6 26.9 0.46 10.1 1.1 4.5 4 0 0 4 4 4 0 Negative regulator of genetic competence (MecA) GTP1_OBG PF01018.22 CDI77930.1 - 1.6e-21 76.5 0.3 1.6e-21 76.5 0.3 2.1 2 0 0 2 2 1 1 GTP1/OBG MMR_HSR1 PF01926.23 CDI77930.1 - 7.3e-13 48.6 0.6 1.8e-12 47.3 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 CDI77930.1 - 0.018 14.8 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FeoB_N PF02421.18 CDI77930.1 - 0.045 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 CDI77930.1 - 0.046 13.8 15.1 0.32 11.0 15.1 2.4 1 1 0 1 1 1 0 Dynamin family Caldesmon PF02029.15 CDI77930.1 - 0.59 8.8 36.4 0.0056 15.5 27.6 1.8 2 0 0 2 2 2 0 Caldesmon DDHD PF02862.17 CDI77930.1 - 0.71 10.0 25.6 0.054 13.7 15.7 2.5 2 0 0 2 2 2 0 DDHD domain BAF1_ABF1 PF04684.13 CDI77930.1 - 0.84 8.6 32.6 0.018 14.2 15.7 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor AAA_23 PF13476.6 CDI77930.1 - 0.96 9.9 0.0 0.96 9.9 0.0 3.6 3 1 0 3 3 2 0 AAA domain Presenilin PF01080.17 CDI77930.1 - 1.1 7.9 39.4 0.018 13.8 24.7 2.2 2 0 0 2 2 2 0 Presenilin Apt1 PF10351.9 CDI77930.1 - 1.4 7.6 30.1 0.056 12.3 11.6 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Band_3_cyto PF07565.13 CDI77930.1 - 4 7.2 31.2 0.34 10.7 22.2 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF2828 PF11443.8 CDI77930.1 - 5.3 5.0 23.6 10 4.1 23.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CRAL_TRIO PF00650.20 CDI77932.1 - 2.3e-12 46.9 0.1 3e-12 46.6 0.1 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain Kinase-like PF14531.6 CDI77933.1 - 1.7e-09 37.4 0.0 2.6e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI77933.1 - 7.5e-08 32.1 0.0 1.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77933.1 - 0.0007 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Tubulin PF00091.25 CDI77934.1 - 3.2e-68 229.8 0.0 6.1e-68 228.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDI77934.1 - 3e-42 143.8 0.0 4.5e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CDI77934.1 - 0.00028 21.2 0.0 0.00073 19.8 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 CDI77934.1 - 0.0053 16.0 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 CDI77934.1 - 0.0066 16.2 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain DUF202 PF02656.15 CDI77935.1 - 0.16 12.4 0.3 0.16 12.4 0.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) COX14 PF14880.6 CDI77935.1 - 0.2 11.5 0.0 0.54 10.1 0.0 1.7 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF2981 PF11200.8 CDI77935.1 - 4 7.1 5.5 6.1 6.5 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) CXCL17 PF15211.6 CDI77936.1 - 0.0073 17.0 0.5 0.025 15.3 0.5 1.9 1 0 0 1 1 1 1 VEGF co-regulated chemokine 1 Vac_Fusion PF02346.16 CDI77936.1 - 0.036 13.7 0.1 0.11 12.1 0.1 1.8 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 Hydrolase PF00702.26 CDI77937.1 - 0.00021 21.6 0.1 0.0018 18.6 0.2 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mcl1_mid PF12341.8 CDI77938.1 - 1.7e-17 63.7 0.0 1.9e-16 60.3 0.0 2.3 1 1 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region LRR_8 PF13855.6 CDI77939.1 - 2.7e-06 27.1 0.0 1.2e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 CDI77939.1 - 2.4e-05 24.6 0.7 0.2 12.2 0.0 3.8 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) Spt20 PF12090.8 CDI77939.1 - 1.6 8.3 7.1 3.6 7.1 7.1 1.5 1 0 0 1 1 1 0 Spt20 family adh_short PF00106.25 CDI77940.1 - 1.2e-09 37.9 0.6 1.6e-09 37.5 0.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDI77940.1 - 1.9e-07 31.2 0.4 2.9e-07 30.6 0.4 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CDI77940.1 - 0.0029 17.2 0.5 0.0051 16.4 0.5 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDI77940.1 - 0.023 14.1 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_19 PF04672.12 CDI77940.1 - 0.027 14.0 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 S-adenosyl methyltransferase Polysacc_synt_2 PF02719.15 CDI77940.1 - 0.036 13.2 0.0 0.045 12.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF4191 PF13829.6 CDI77940.1 - 0.044 13.1 1.4 0.065 12.6 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) YjeF_N PF03853.15 CDI77940.1 - 0.076 12.9 0.1 0.095 12.6 0.1 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Phage_holin_3_6 PF07332.11 CDI77940.1 - 0.082 12.9 2.8 0.22 11.6 2.8 1.7 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DFP PF04127.15 CDI77940.1 - 0.15 11.9 0.5 0.33 10.8 0.3 1.7 1 1 1 2 2 2 0 DNA / pantothenate metabolism flavoprotein UBA_4 PF14555.6 CDI77943.1 - 1.5e-06 27.9 0.0 2.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 CDI77943.1 - 4.4e-06 26.8 0.2 1.2e-05 25.4 0.2 1.7 1 0 0 1 1 1 1 Thioredoxin-like ABC_membrane PF00664.23 CDI77944.1 - 7.6e-79 265.2 2.1 6.3e-47 160.5 0.3 2.9 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDI77944.1 - 1.7e-48 164.6 0.0 8.3e-34 117.0 0.0 3.3 2 1 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 CDI77944.1 - 5.5e-09 36.6 0.2 0.004 17.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 CDI77944.1 - 3e-07 30.8 0.1 0.038 14.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CDI77944.1 - 4.5e-07 29.9 0.0 0.041 13.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CDI77944.1 - 5.5e-07 29.2 0.0 0.033 13.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CDI77944.1 - 6.1e-07 29.8 0.2 0.02 15.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDI77944.1 - 6.4e-07 29.3 0.6 0.00053 19.8 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CDI77944.1 - 1.5e-06 27.9 0.4 0.035 13.6 0.0 3.3 3 0 0 3 3 3 2 P-loop containing dynein motor region SMC_N PF02463.19 CDI77944.1 - 1.7e-06 27.7 0.7 0.0014 18.1 0.0 3.1 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDI77944.1 - 2.3e-06 27.6 0.0 0.0097 15.7 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CDI77944.1 - 2.8e-06 27.0 0.0 0.43 10.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 CDI77944.1 - 4.8e-06 27.0 0.0 0.0042 17.5 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDI77944.1 - 1.8e-05 24.8 0.1 0.12 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 CDI77944.1 - 6.2e-05 23.0 0.0 0.27 11.0 0.0 2.9 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 CDI77944.1 - 6.8e-05 22.2 0.1 0.16 11.1 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Zeta_toxin PF06414.12 CDI77944.1 - 0.00031 20.1 0.0 0.17 11.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Rad17 PF03215.15 CDI77944.1 - 0.00038 20.4 0.1 0.65 9.9 0.1 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain MMR_HSR1 PF01926.23 CDI77944.1 - 0.00054 20.0 0.1 1.1 9.4 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_24 PF13479.6 CDI77944.1 - 0.00075 19.3 0.0 0.08 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 CDI77944.1 - 0.001 18.8 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 CDI77944.1 - 0.0011 18.2 0.0 0.4 9.8 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain PRK PF00485.18 CDI77944.1 - 0.0015 18.3 0.3 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 CDI77944.1 - 0.0015 19.1 0.0 1.9 9.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDI77944.1 - 0.0021 18.6 0.2 3.7 8.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDI77944.1 - 0.0053 17.1 0.1 4.4 7.7 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.6 CDI77944.1 - 0.0069 16.8 0.6 3.3 8.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain Viral_helicase1 PF01443.18 CDI77944.1 - 0.0082 15.9 1.0 2.8 7.6 0.1 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ABC_ATPase PF09818.9 CDI77944.1 - 0.0087 14.9 0.1 0.37 9.5 0.1 2.3 2 0 0 2 2 2 1 Predicted ATPase of the ABC class NTPase_1 PF03266.15 CDI77944.1 - 0.009 15.9 1.3 2.1 8.2 0.5 3.1 2 1 0 2 2 2 1 NTPase AAA_14 PF13173.6 CDI77944.1 - 0.0098 15.9 0.2 6.4 6.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CDI77944.1 - 0.011 14.9 0.1 2.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TniB PF05621.11 CDI77944.1 - 0.014 14.8 0.1 6.2 6.2 0.0 2.9 3 0 0 3 3 3 0 Bacterial TniB protein FeoB_N PF02421.18 CDI77944.1 - 0.016 14.8 0.1 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_33 PF13671.6 CDI77944.1 - 0.02 15.1 0.6 5.1 7.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain NACHT PF05729.12 CDI77944.1 - 0.022 14.7 1.7 5.3 6.9 0.1 2.9 3 0 0 3 3 3 0 NACHT domain IstB_IS21 PF01695.17 CDI77944.1 - 0.024 14.4 0.2 5.4 6.7 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein Roc PF08477.13 CDI77944.1 - 0.034 14.4 0.3 11 6.3 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 CDI77944.1 - 0.046 14.1 0.1 2.7 8.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDI77944.1 - 0.08 12.7 0.4 15 5.3 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Guanylate_kin PF00625.21 CDI77944.1 - 0.098 12.3 0.2 7.5 6.2 0.0 2.8 3 0 0 3 3 3 0 Guanylate kinase Ploopntkinase3 PF18751.1 CDI77944.1 - 0.1 12.5 0.0 6.6 6.6 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Ras PF00071.22 CDI77944.1 - 0.11 12.1 0.3 14 5.2 0.0 2.4 2 0 0 2 2 2 0 Ras family KAP_NTPase PF07693.14 CDI77944.1 - 0.11 11.8 0.0 3 7.0 0.0 2.4 2 1 1 3 3 3 0 KAP family P-loop domain CoaE PF01121.20 CDI77944.1 - 0.11 12.1 0.2 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Dephospho-CoA kinase ATPase PF06745.13 CDI77944.1 - 0.15 11.4 1.9 7 5.9 0.0 2.6 3 0 0 3 3 2 0 KaiC Spt20 PF12090.8 CDI77945.1 - 0.00013 21.7 12.9 0.00013 21.7 12.9 9.9 7 2 2 9 9 9 4 Spt20 family RskA PF10099.9 CDI77945.1 - 0.0037 17.6 16.3 0.0037 17.6 16.3 13.1 3 2 5 8 8 8 2 Anti-sigma-K factor rskA RskA PF10099.9 CDI77946.1 - 0.00096 19.5 0.3 0.00096 19.5 0.3 11.3 6 3 3 9 9 9 2 Anti-sigma-K factor rskA zf-RING_UBOX PF13445.6 CDI77947.1 - 1.2e-05 25.3 6.5 1.2e-05 25.3 6.5 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI77947.1 - 0.00035 20.5 5.6 0.00035 20.5 5.6 3.7 5 0 0 5 5 5 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDI77947.1 - 0.003 17.4 5.8 0.003 17.4 5.8 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) DUF2722 PF10846.8 CDI77947.1 - 0.0041 16.1 5.2 0.0041 16.1 5.2 6.7 7 0 0 7 7 7 3 Protein of unknown function (DUF2722) zf-RING_2 PF13639.6 CDI77947.1 - 0.0051 17.1 8.3 0.0051 17.1 8.3 3.4 4 0 0 4 4 4 1 Ring finger domain CPBP PF02517.16 CDI77947.1 - 0.79 10.1 3.8 11 6.4 0.6 3.7 3 0 0 3 3 3 0 CPBP intramembrane metalloprotease G0-G1_switch_2 PF15103.6 CDI77947.1 - 1.6 9.2 0.0 1.6 9.2 0.0 7.3 7 0 0 7 7 7 0 G0/G1 switch protein 2 GvpH PF05455.11 CDI77948.1 - 0.58 10.2 5.5 3.2 7.8 5.5 2.3 1 0 0 1 1 1 0 GvpH BRCT PF00533.26 CDI77949.1 - 4.4e-12 46.2 0.0 9.3e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-met PF12874.7 CDI77950.1 - 0.14 12.6 0.5 0.3 11.5 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDI77950.1 - 0.14 12.5 1.6 0.26 11.6 1.6 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Kelch_6 PF13964.6 CDI77951.1 - 1.8e-11 43.9 4.4 0.00085 19.5 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 CDI77951.1 - 2.4e-08 33.8 0.2 0.0074 16.3 0.1 4.5 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 CDI77951.1 - 5.6e-07 29.1 5.4 0.00095 18.7 0.3 4.2 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 CDI77951.1 - 1.1e-05 25.3 10.3 0.081 12.9 0.6 5.1 3 1 1 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI77951.1 - 4.3e-05 23.3 8.8 0.00023 21.0 0.0 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 CDI77951.1 - 0.00069 19.8 0.1 0.00069 19.8 0.1 5.6 6 1 0 6 6 6 1 Galactose oxidase, central domain Spt20 PF12090.8 CDI77951.1 - 0.0024 17.5 22.9 0.0024 17.5 22.9 6.0 6 1 0 6 6 6 1 Spt20 family PSD3 PF07626.11 CDI77952.1 - 0.047 14.2 1.5 0.56 10.7 1.5 3.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) HHH_8 PF14716.6 CDI77953.1 - 0.031 14.6 0.4 0.068 13.5 0.4 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_9 PF17674.1 CDI77953.1 - 1.4 9.9 4.2 1.1 10.2 0.5 2.6 2 1 0 2 2 2 0 HHH domain RskA PF10099.9 CDI77953.1 - 1.6 9.0 18.6 1.3e+02 2.8 18.6 2.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI77953.1 - 3.8 8.2 17.6 0.49 11.0 8.3 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region WD40 PF00400.32 CDI77956.1 - 4.4e-06 27.3 4.0 0.0039 18.0 0.1 3.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Ribosomal_60s PF00428.19 CDI77956.1 - 0.36 11.4 10.5 1.4 9.5 0.2 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein IMUP PF15761.5 CDI77956.1 - 7.7 7.3 28.6 0.59 10.9 2.4 3.9 4 0 0 4 4 4 0 Immortalisation up-regulated protein Chorion_2 PF03964.15 CDI77956.1 - 8.3 7.3 23.8 23 5.9 1.5 4.2 4 0 0 4 4 4 0 Chorion family 2 DUF4357 PF14267.6 CDI77956.1 - 9.1 6.3 7.8 1.3 9.0 0.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) HECT PF00632.25 CDI77957.1 - 2e-42 145.8 0.0 9.8e-42 143.5 0.0 2.1 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.6 CDI77957.1 - 1.7e-07 31.5 0.0 0.00073 19.7 0.0 3.0 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Glycoprot_B_PH1 PF17416.2 CDI77957.1 - 0.19 11.3 0.7 0.51 9.9 0.7 1.7 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B CDC37_N PF03234.14 CDI77958.1 - 0.32 11.9 5.8 0.49 11.3 0.5 2.9 3 0 0 3 3 3 0 Cdc37 N terminal kinase binding Hormone_2 PF00123.20 CDI77959.1 - 0.064 13.2 0.0 1.5 8.8 0.0 2.9 2 0 0 2 2 2 0 Peptide hormone Macoilin PF09726.9 CDI77961.1 - 0.77 8.2 19.2 0.96 7.9 19.2 1.0 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CDI77961.1 - 0.87 9.4 14.4 0.93 9.3 14.4 1.0 1 0 0 1 1 1 0 SPX domain SRP-alpha_N PF04086.13 CDI77961.1 - 3.9 7.3 13.1 5 7.0 13.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TFIIA PF03153.13 CDI77961.1 - 4.1 7.3 15.3 4.6 7.1 15.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SWI-SNF_Ssr4 PF08549.10 CDI77961.1 - 4.5 5.8 12.3 4.9 5.7 12.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Miga PF10265.9 CDI77961.1 - 5.5 5.9 13.1 6.5 5.6 13.1 1.1 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 CDI77961.1 - 5.7 5.6 9.9 8.9 5.0 9.9 1.2 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 CDI77961.1 - 7.4 5.3 15.1 8 5.2 15.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RskA PF10099.9 CDI77963.1 - 0.031 14.6 0.6 0.031 14.6 0.6 8.4 1 1 3 4 4 4 0 Anti-sigma-K factor rskA XhlA PF10779.9 CDI77965.1 - 0.26 11.5 7.8 9.5 6.5 2.6 3.7 2 0 0 2 2 2 0 Haemolysin XhlA Exonuc_VII_L PF02601.15 CDI77966.1 - 0.014 15.0 8.5 0.017 14.7 8.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec23_trunk PF04811.15 CDI77966.1 - 1.3 8.6 9.5 1.9 8.0 9.5 1.3 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain FliP PF00813.20 CDI77966.1 - 1.5 8.7 12.2 0.33 10.8 8.5 1.8 1 1 0 1 1 1 0 FliP family V_ATPase_I PF01496.19 CDI77966.1 - 2.1 6.2 10.8 2.6 5.9 10.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.6 CDI77966.1 - 2.7 8.4 16.0 3.6 8.0 16.0 1.2 1 0 0 1 1 1 0 AAA domain DUF4484 PF14831.6 CDI77966.1 - 4.1 7.4 10.8 0.52 10.3 6.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Orf78 PF06024.12 CDI77966.1 - 4.6 7.6 0.0 4.6 7.6 0.0 2.6 2 1 0 2 2 2 0 Orf78 (ac78) Hexokinase_1 PF00349.21 CDI77967.1 - 6.2e-16 58.9 0.0 7.4e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CDI77967.1 - 1.6e-08 34.2 0.1 2.2e-08 33.9 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Alpha-amylase PF00128.24 CDI77969.1 - 1.3e-14 54.6 0.0 1.4e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain RRM_1 PF00076.22 CDI77972.1 - 4e-25 87.4 0.0 6.7e-16 57.9 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI77972.1 - 0.0013 18.5 0.0 19 5.2 0.0 4.0 3 1 0 3 3 3 3 Occluded RNA-recognition motif RRM_7 PF16367.5 CDI77972.1 - 0.18 12.0 0.0 1.4 9.0 0.0 2.4 3 0 0 3 3 3 0 RNA recognition motif Abi_C PF14355.6 CDI77973.1 - 0.11 12.7 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Abortive infection C-terminus PRTase_1 PF11202.8 CDI77974.1 - 0.013 14.7 0.1 0.023 13.9 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) NAD_binding_1 PF00175.21 CDI77975.1 - 2.1e-16 60.5 0.0 3.3e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CDI77975.1 - 0.18 12.2 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Pkinase PF00069.25 CDI77976.1 - 1.9e-59 201.2 1.8 9e-36 123.6 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI77976.1 - 1.6e-26 93.2 4.4 1.8e-18 66.7 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Draxin PF15550.6 CDI77976.1 - 0.21 11.4 11.9 0.12 12.2 8.9 2.1 2 0 0 2 2 2 0 Draxin Kinase-like PF14531.6 CDI77976.1 - 0.42 9.9 0.0 0.42 9.9 0.0 3.5 4 0 0 4 4 4 0 Kinase-like RIO1 PF01163.22 CDI77976.1 - 6.8 6.2 8.3 3.1 7.4 0.0 2.3 2 0 0 2 2 2 0 RIO1 family DUF2722 PF10846.8 CDI77978.1 - 0.00055 19.0 5.1 1.2 8.0 0.1 3.2 3 0 0 3 3 3 3 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI77978.1 - 0.0035 17.0 17.4 0.077 12.6 0.3 3.1 3 0 0 3 3 3 3 Spt20 family Vert_HS_TF PF06546.11 CDI77978.1 - 0.024 14.3 0.2 0.024 14.3 0.2 2.0 2 0 0 2 2 2 0 Vertebrate heat shock transcription factor TFIIA PF03153.13 CDI77978.1 - 0.14 12.1 14.0 2 8.4 0.4 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit FTZ PF03867.14 CDI77978.1 - 3.1 7.3 10.6 1.8 8.0 0.4 3.4 3 0 0 3 3 3 0 Fushi tarazu (FTZ), N-terminal region LEA_3 PF03242.13 CDI77979.1 - 0.0041 17.8 1.2 0.0041 17.8 1.2 10.0 14 0 0 14 14 14 1 Late embryogenesis abundant protein S_locus_glycop PF00954.20 CDI77979.1 - 0.02 15.4 2.0 0.068 13.7 0.6 2.6 2 0 0 2 2 2 0 S-locus glycoprotein domain ACDC PF14733.6 CDI77980.1 - 3e-07 30.7 0.0 0.0037 17.5 0.0 2.7 2 0 0 2 2 2 2 AP2-coincident C-terminal Sporozoite_P67 PF05642.11 CDI77980.1 - 5.2e-05 21.6 16.5 5.2e-05 21.6 16.5 2.8 3 0 0 3 3 3 1 Sporozoite P67 surface antigen AAA_23 PF13476.6 CDI77981.1 - 0.016 15.7 4.6 0.02 15.4 4.6 1.2 1 0 0 1 1 1 0 AAA domain CdvA PF18822.1 CDI77981.1 - 0.019 14.8 3.3 0.03 14.2 3.3 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain DUF5320 PF17253.2 CDI77981.1 - 0.062 14.4 1.8 0.062 14.4 1.8 2.7 1 1 2 3 3 3 0 Family of unknown function (DUF5320) Mit_KHE1 PF10173.9 CDI77981.1 - 0.17 12.0 0.7 0.29 11.2 0.7 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related TSC22 PF01166.18 CDI77981.1 - 5.7 7.3 7.6 13 6.2 7.6 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family CLPTM1 PF05602.12 CDI77982.1 - 1.3e-22 80.4 0.2 1.8e-22 80.0 0.2 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) AMO PF02461.16 CDI77982.1 - 0.0014 18.5 0.8 0.002 18.0 0.8 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase MITF_TFEB_C_3_N PF15951.5 CDI77983.1 - 0.037 14.7 8.3 0.037 14.7 8.3 3.8 3 2 0 3 3 3 0 MITF/TFEB/TFEC/TFE3 N-terminus MACPF PF01823.19 CDI77983.1 - 0.1 12.7 6.3 2.7 8.0 4.0 2.3 2 1 0 2 2 2 0 MAC/Perforin domain TFIIA PF03153.13 CDI77983.1 - 1 9.3 52.7 4.4 7.2 52.9 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LMBR1 PF04791.16 CDI77983.1 - 1.5 7.6 3.0 1.9 7.3 3.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CCDC106 PF15794.5 CDI77983.1 - 3.1 7.5 45.0 0.05 13.3 9.5 3.0 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 106 PGA2 PF07543.12 CDI77983.1 - 9.9 6.1 21.9 1.7 8.6 2.8 3.1 3 0 0 3 3 3 0 Protein trafficking PGA2 Ribosomal_L17 PF01196.19 CDI77987.1 - 3e-20 72.9 0.2 4.8e-20 72.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 DUF2722 PF10846.8 CDI77990.1 - 0.0013 17.8 2.1 0.0013 17.8 2.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF2914 PF11141.8 CDI77990.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) Pex14_N PF04695.13 CDI77990.1 - 0.14 12.8 18.0 0.034 14.8 6.6 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI77990.1 - 0.17 12.2 0.0 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like AFT PF08731.11 CDI77990.1 - 0.71 10.3 5.6 0.088 13.2 0.7 1.9 2 0 0 2 2 2 0 Transcription factor AFT Herpes_UL32 PF06070.11 CDI77990.1 - 2.3 5.8 8.5 3.6 5.2 8.5 1.2 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 TFIIA PF03153.13 CDI77990.1 - 3.5 7.5 35.3 0.8 9.6 18.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI77990.1 - 5.8 6.9 5.3 3.7 7.6 1.3 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RskA PF10099.9 CDI77990.1 - 8.9 6.6 26.5 0.043 14.1 13.2 2.8 1 1 1 2 2 2 0 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI77991.1 - 0.006 16.2 6.8 0.006 16.2 6.8 5.6 4 1 2 6 6 6 2 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI77991.1 - 0.069 13.1 91.4 0.095 12.7 21.6 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Otopetrin PF03189.13 CDI77991.1 - 0.46 9.2 0.0 0.46 9.2 0.0 2.9 2 2 0 2 2 2 0 Otopetrin EF-hand_7 PF13499.6 CDI77992.1 - 1.3e-13 51.2 0.0 6.6e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI77992.1 - 4.1e-12 44.7 0.0 9.7e-07 27.9 0.0 3.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 CDI77992.1 - 7e-12 44.3 0.1 1.4e-06 27.8 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDI77992.1 - 7.6e-07 28.4 0.0 0.00064 19.1 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI77992.1 - 8e-06 25.6 0.0 1 9.2 0.0 3.9 2 1 1 3 3 3 2 EF-hand domain pair DDHD PF02862.17 CDI77992.1 - 0.00064 19.9 5.1 0.00089 19.5 5.1 1.3 1 0 0 1 1 1 1 DDHD domain DUF5580 PF17743.1 CDI77992.1 - 0.0022 16.6 3.3 0.0022 16.6 3.3 1.5 1 1 1 2 2 2 1 Family of unknown function (DUF5580) EF-hand_9 PF14658.6 CDI77992.1 - 0.0034 17.7 0.0 0.015 15.6 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain TFIIA PF03153.13 CDI77992.1 - 0.006 16.6 28.7 0.0079 16.2 28.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI77992.1 - 0.01 16.1 22.4 0.13 12.5 12.1 2.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI77992.1 - 0.02 15.4 0.2 1.1 9.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Excalibur PF05901.11 CDI77992.1 - 0.022 15.3 0.0 0.31 11.7 0.0 2.7 2 1 0 2 2 2 0 Excalibur calcium-binding domain Caleosin PF05042.13 CDI77992.1 - 0.035 14.0 0.0 0.42 10.5 0.0 2.6 3 1 1 4 4 4 0 Caleosin related protein Gastrin PF00918.17 CDI77992.1 - 0.14 13.2 9.4 0.34 11.9 9.4 1.7 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Presenilin PF01080.17 CDI77992.1 - 0.67 8.7 9.9 0.78 8.4 9.9 1.1 1 0 0 1 1 1 0 Presenilin DUF4148 PF13663.6 CDI77992.1 - 1.1 9.5 16.6 5.2 7.3 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) PAT1 PF09770.9 CDI77992.1 - 1.4 7.1 22.8 1.6 6.9 22.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ribosomal_60s PF00428.19 CDI77992.1 - 1.4 9.6 16.3 3 8.5 6.7 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Exonuc_VII_L PF02601.15 CDI77992.1 - 1.7 8.1 17.1 0.24 10.9 13.6 1.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit Peptidase_S15 PF02129.18 CDI77992.1 - 1.9 8.0 13.8 2.9 7.4 13.8 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) TERB2 PF15101.6 CDI77992.1 - 2.6 8.0 12.4 4.1 7.4 12.4 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MCU PF04678.13 CDI77992.1 - 3.7 7.6 8.3 8.2 6.5 8.3 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Pex14_N PF04695.13 CDI77992.1 - 8 7.1 22.9 14 6.3 22.9 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TMF_TATA_bd PF12325.8 CDI77996.1 - 0.0019 18.4 2.0 0.0019 18.4 2.0 1.7 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding Lzipper-MIP1 PF14389.6 CDI77996.1 - 0.016 15.5 0.4 0.016 15.5 0.4 1.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 FlxA PF14282.6 CDI77996.1 - 0.027 14.5 4.1 0.027 14.5 4.1 2.7 2 1 0 2 2 2 0 FlxA-like protein DUF4674 PF15719.5 CDI77996.1 - 0.12 12.4 8.1 0.16 12.0 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) GT87 PF09594.10 CDI77996.1 - 0.21 11.3 6.0 0.28 10.9 6.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 87 Peptidase_S64 PF08192.11 CDI77996.1 - 0.24 9.9 8.9 0.29 9.6 8.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3450 PF11932.8 CDI77996.1 - 0.31 10.3 16.2 0.59 9.4 6.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SPX PF03105.19 CDI77996.1 - 0.77 9.6 15.5 0.95 9.3 15.5 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI77996.1 - 0.92 8.3 12.3 1.1 8.0 12.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 CDI77996.1 - 1.2 8.7 38.3 2.8 7.5 16.8 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI77996.1 - 2.7 8.3 29.1 4.4 7.6 12.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) CHDCT2 PF08074.11 CDI77996.1 - 2.7 8.1 5.8 7.4 6.7 5.8 1.8 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain Dehydrin PF00257.19 CDI77996.1 - 4.1 7.9 30.8 0.51 10.9 11.7 2.2 1 1 1 2 2 2 0 Dehydrin SR-25 PF10500.9 CDI77998.1 - 1.5 8.4 14.5 2.2 7.8 14.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sporozoite_P67 PF05642.11 CDI77998.1 - 2.9 5.8 8.4 3.8 5.5 8.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Period_C PF12114.8 CDI77998.1 - 6.4 6.3 11.8 8.3 5.9 11.8 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region FAM199X PF15814.5 CDI77999.1 - 0.0064 15.6 9.1 0.0064 15.6 9.1 4.8 3 1 2 5 5 5 1 Protein family FAM199X Spt20 PF12090.8 CDI77999.1 - 0.0069 16.0 8.7 0.0069 16.0 8.7 3.5 3 1 0 3 3 3 2 Spt20 family DUF2722 PF10846.8 CDI77999.1 - 5.4 5.8 39.9 0.015 14.2 7.9 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) DUF1180 PF06679.12 CDI78000.1 - 0.0029 18.1 0.4 0.0029 18.1 0.4 11.0 7 4 3 11 11 11 2 Protein of unknown function (DUF1180) Phostensin_N PF13916.6 CDI78000.1 - 4 7.8 9.9 12 6.4 1.0 3.4 3 0 0 3 3 3 0 PP1-regulatory protein, Phostensin N-terminal RVT_1 PF00078.27 CDI78002.1 - 0.00026 20.6 0.0 0.0004 20.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exotox-A_cataly PF09009.10 CDI78003.1 - 0.2 11.4 0.0 0.26 11.0 0.0 1.1 1 0 0 1 1 1 0 Exotoxin A catalytic GREB1 PF15782.5 CDI78005.1 - 0.29 8.2 0.1 0.3 8.2 0.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI78006.1 - 1.3 8.9 43.7 0.0088 16.1 5.6 4.4 4 0 0 4 4 4 0 Transcription factor IIA, alpha/beta subunit PAM2 PF07145.15 CDI78007.1 - 0.0004 19.9 1.1 6.5 6.7 0.0 3.6 3 0 0 3 3 3 2 Ataxin-2 C-terminal region TFIIA PF03153.13 CDI78007.1 - 0.00099 19.2 15.7 0.00099 19.2 15.7 4.9 2 1 2 4 4 4 1 Transcription factor IIA, alpha/beta subunit MLANA PF14991.6 CDI78007.1 - 2.2 8.6 6.8 9 6.6 6.8 2.1 1 0 0 1 1 1 0 Protein melan-A DUF3533 PF12051.8 CDI78007.1 - 2.9 6.7 6.2 5.7 5.8 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) SID-1_RNA_chan PF13965.6 CDI78007.1 - 6 5.2 7.1 22 3.3 4.3 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 RRN3 PF05327.11 CDI78007.1 - 9.5 4.6 18.7 0.052 12.1 4.8 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 ATP_bind_3 PF01171.20 CDI78010.1 - 9.5e-30 103.7 0.6 1.5e-24 86.8 0.1 3.7 2 1 0 2 2 2 2 PP-loop family Hemolysin_N PF12563.8 CDI78010.1 - 0.0021 17.7 0.1 0.009 15.6 0.1 2.1 1 0 0 1 1 1 1 Hemolytic toxin N terminal NDUF_B12 PF08122.12 CDI78010.1 - 0.026 14.6 0.1 0.32 11.1 0.0 3.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family TLD PF07534.16 CDI78011.1 - 1e-20 74.4 0.2 2e-20 73.4 0.2 1.4 1 0 0 1 1 1 1 TLD E7 PF00527.18 CDI78011.1 - 4.3 7.6 12.8 2.7 8.3 5.1 3.3 3 0 0 3 3 3 0 E7 protein, Early protein MitMem_reg PF13012.6 CDI78012.1 - 5.9e-33 113.6 0.7 9.5e-33 113.0 0.7 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CDI78012.1 - 1.2e-24 86.5 0.6 2.8e-24 85.3 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Actin PF00022.19 CDI78013.1 - 1.7e-19 69.7 0.0 2.3e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Actin TAF4 PF05236.14 CDI78013.1 - 0.033 13.9 4.1 0.056 13.2 4.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family TFIIA PF03153.13 CDI78013.1 - 0.066 13.2 7.4 0.092 12.7 7.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BSP_II PF05432.11 CDI78013.1 - 0.08 12.6 2.8 0.12 12.1 2.8 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2722 PF10846.8 CDI78013.1 - 0.15 10.9 4.8 0.21 10.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Peptidase_S15 PF02129.18 CDI78013.1 - 0.16 11.5 4.4 0.34 10.5 4.4 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SUIM_assoc PF16619.5 CDI78013.1 - 0.19 11.8 8.6 0.5 10.5 8.6 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spore_coat_CotO PF14153.6 CDI78013.1 - 0.9 9.4 8.2 1.4 8.9 8.2 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Roughex PF06020.11 CDI78013.1 - 3.8 6.5 9.7 6 5.9 9.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF1180 PF06679.12 CDI78013.1 - 6.3 7.2 7.6 14 6.1 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Spt20 PF12090.8 CDI78013.1 - 6.4 6.3 11.6 11 5.5 11.6 1.3 1 0 0 1 1 1 0 Spt20 family Peptidase_M1_N PF17900.1 CDI78014.1 - 0.0031 17.7 0.0 0.0031 17.7 0.0 2.5 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain PAP1 PF08601.10 CDI78016.1 - 0.0096 15.7 31.8 0.011 15.5 31.8 1.0 1 0 0 1 1 1 1 Transcription factor PAP1 DUF936 PF06075.12 CDI78016.1 - 0.039 12.9 19.3 0.045 12.7 19.3 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Macoilin PF09726.9 CDI78016.1 - 0.042 12.4 21.5 0.059 11.9 21.5 1.2 1 0 0 1 1 1 0 Macoilin family Utp14 PF04615.13 CDI78016.1 - 0.51 8.9 18.2 0.57 8.7 18.2 1.0 1 0 0 1 1 1 0 Utp14 protein SPX PF03105.19 CDI78016.1 - 0.85 9.5 30.1 1.1 9.1 30.1 1.0 1 0 0 1 1 1 0 SPX domain EFTUD2 PF16004.5 CDI78016.1 - 0.89 10.2 10.0 3.9 8.1 1.5 2.3 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus CytochromB561_N PF09786.9 CDI78016.1 - 3.7 6.4 22.8 4.6 6.1 22.8 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal ABC_tran_Xtn PF12848.7 CDI78016.1 - 7.4 6.7 16.6 6.6 6.8 6.7 2.3 2 0 0 2 2 2 0 ABC transporter Striatin PF08232.12 CDI78017.1 - 0.012 16.2 1.3 0.012 16.2 1.3 2.8 2 1 0 2 2 2 0 Striatin family SPX PF03105.19 CDI78017.1 - 0.09 12.7 32.7 0.17 11.8 2.1 2.0 2 0 0 2 2 2 0 SPX domain DUF4667 PF15700.5 CDI78017.1 - 1.3 9.0 36.6 0.36 10.9 5.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Nop25 PF09805.9 CDI78017.1 - 1.8 9.1 15.3 6.8 7.2 0.2 2.2 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) DUF1635 PF07795.11 CDI78017.1 - 2.5 7.9 25.7 0.83 9.5 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF5523 PF17661.1 CDI78017.1 - 2.8 7.6 14.3 1.1 8.9 11.7 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5523) Spt20 PF12090.8 CDI78017.1 - 6.4 6.3 41.0 0.23 11.0 26.5 2.1 2 0 0 2 2 2 0 Spt20 family Pepsin-I3 PF06394.13 CDI78018.1 - 0.12 12.6 1.0 0.26 11.5 1.0 1.5 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain DUF1180 PF06679.12 CDI78018.1 - 1.1 9.7 13.7 0.034 14.5 7.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) HVSL PF09749.9 CDI78019.1 - 2.9e-14 53.1 18.9 1.4e-13 50.8 14.3 3.2 1 1 1 2 2 2 2 Uncharacterised conserved protein SPX PF03105.19 CDI78019.1 - 0.00016 21.7 5.1 0.00016 21.7 5.1 2.5 1 1 1 2 2 2 1 SPX domain SLC12 PF03522.15 CDI78019.1 - 4.3 6.2 22.2 1.9 7.4 4.0 2.4 2 0 0 2 2 2 0 Solute carrier family 12 PMI_typeI PF01238.21 CDI78020.1 - 8.8e-44 150.2 23.3 6.5e-23 81.5 8.5 4.4 1 1 2 3 3 3 2 Phosphomannose isomerase type I RR_TM4-6 PF06459.12 CDI78020.1 - 0.0053 16.6 6.2 0.0053 16.6 6.2 4.4 4 0 0 4 4 4 1 Ryanodine Receptor TM 4-6 Cupin_3 PF05899.12 CDI78020.1 - 0.17 11.6 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF861) TOM13 PF08219.11 CDI78020.1 - 0.28 11.2 0.1 0.28 11.2 0.1 5.2 5 2 2 7 7 7 0 Outer membrane protein TOM13 Oxidored_q6 PF01058.22 CDI78020.1 - 0.53 10.1 3.5 0.89 9.4 0.0 3.0 3 1 0 3 3 3 0 NADH ubiquinone oxidoreductase, 20 Kd subunit X PF00739.19 CDI78020.1 - 1.5 8.9 5.0 0.66 10.1 0.6 2.4 2 0 0 2 2 2 0 Trans-activation protein X SARAF PF06682.12 CDI78020.1 - 2.4 7.7 37.7 0.16 11.6 11.6 3.8 3 1 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis CRT-like PF08627.10 CDI78021.1 - 5.1e-09 35.5 0.9 8.8e-07 28.2 0.1 2.1 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like TFIIA PF03153.13 CDI78021.1 - 0.0076 16.3 34.4 0.0076 16.3 34.4 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 CDI78021.1 - 0.03 13.5 11.0 1.4 8.1 0.2 2.7 2 0 0 2 2 2 0 ZIP Zinc transporter AMP-binding PF00501.28 CDI78021.1 - 0.045 12.4 0.8 0.077 11.6 0.8 1.3 1 0 0 1 1 1 0 AMP-binding enzyme V_ATPase_I PF01496.19 CDI78021.1 - 0.2 9.6 8.4 0.36 8.7 8.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NEMP PF10225.9 CDI78021.1 - 0.4 10.3 5.7 0.9 9.2 5.7 1.6 1 0 0 1 1 1 0 NEMP family EamA PF00892.20 CDI78021.1 - 0.78 9.9 13.8 0.096 12.9 9.3 1.8 2 0 0 2 2 2 0 EamA-like transporter family DUF2052 PF09747.9 CDI78021.1 - 1.6 8.8 18.6 3.8 7.6 18.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Roughex PF06020.11 CDI78021.1 - 2.1 7.3 17.3 4.3 6.3 17.3 1.5 1 0 0 1 1 1 0 Drosophila roughex protein PAT1 PF09770.9 CDI78021.1 - 3.5 5.8 23.3 4.9 5.3 23.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PA26 PF04636.13 CDI78021.1 - 5.6 5.8 9.0 10 4.9 9.0 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FHIPEP PF00771.20 CDI78021.1 - 7.6 4.9 8.6 0.59 8.5 3.8 1.5 2 0 0 2 2 2 0 FHIPEP family eIF-3_zeta PF05091.12 CDI78021.1 - 9.2 5.1 15.2 14 4.5 15.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SUIM_assoc PF16619.5 CDI78022.1 - 0.013 15.6 1.4 0.013 15.6 1.4 7.6 4 3 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 SUIM_assoc PF16619.5 CDI78023.1 - 0.043 13.9 4.0 0.065 13.3 4.0 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 ATP-synt_ab PF00006.25 CDI78026.1 - 8.1e-66 221.7 0.0 1.2e-65 221.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDI78026.1 - 7.4e-10 39.2 0.1 1.4e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain SR-25 PF10500.9 CDI78027.1 - 0.027 14.1 4.1 1.1 8.8 0.4 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDI78027.1 - 0.044 14.1 11.7 0.23 11.8 4.1 2.6 2 1 0 2 2 2 0 Early growth response N-terminal domain Spt20 PF12090.8 CDI78027.1 - 0.69 9.5 6.3 0.36 10.4 3.1 2.0 2 0 0 2 2 2 0 Spt20 family IMUP PF15761.5 CDI78027.1 - 0.97 10.2 7.8 11 6.8 0.6 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF1645 PF07816.11 CDI78028.1 - 0.0019 18.8 0.3 0.0019 18.8 0.3 8.1 6 4 1 7 7 7 2 Protein of unknown function (DUF1645) Memo PF01875.17 CDI78030.1 - 2.3e-31 109.0 0.0 1.5e-22 80.1 0.0 2.0 1 1 1 2 2 2 2 Memo-like protein ECR1_N PF14382.6 CDI78031.1 - 2.8e-08 33.4 0.3 4.8e-08 32.7 0.3 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region TCP PF03634.13 CDI78035.1 - 0.0027 18.3 8.8 0.0027 18.3 8.8 3.9 3 1 0 4 4 4 1 TCP family transcription factor Connexin PF00029.19 CDI78035.1 - 0.0065 16.3 1.9 0.0065 16.3 1.9 2.8 3 0 0 3 3 3 1 Connexin DUF4746 PF15928.5 CDI78035.1 - 0.0072 15.8 5.1 0.0072 15.8 5.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4746) Spt20 PF12090.8 CDI78035.1 - 0.052 13.2 74.1 0.11 12.1 35.1 3.4 3 0 0 3 3 3 0 Spt20 family HNOBA PF07701.14 CDI78035.1 - 0.17 11.3 9.6 0.05 13.0 0.3 3.0 3 0 0 3 3 3 0 Heme NO binding associated Afi1 PF07792.12 CDI78035.1 - 0.2 12.1 18.2 0.51 10.8 7.5 3.2 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MAM33 PF02330.16 CDI78035.1 - 0.37 10.7 20.2 6 6.8 8.1 3.3 3 0 0 3 3 3 0 Mitochondrial glycoprotein Rrp15p PF07890.12 CDI78035.1 - 0.55 10.6 25.3 0.03 14.7 5.3 3.8 3 0 0 3 3 3 0 Rrp15p SpoIIP PF07454.11 CDI78035.1 - 0.57 9.6 27.5 0.053 13.0 9.2 3.1 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Rxt3 PF08642.10 CDI78035.1 - 0.73 10.6 13.7 0.45 11.3 2.3 3.6 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 DUF4770 PF15994.5 CDI78035.1 - 0.76 10.0 26.0 0.2 11.9 9.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) SID-1_RNA_chan PF13965.6 CDI78035.1 - 1.4 7.3 5.3 0.33 9.3 1.0 1.9 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF719 PF05334.13 CDI78035.1 - 1.5 9.0 21.3 8.4 6.5 8.3 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF719) PRC2_HTH_1 PF18118.1 CDI78035.1 - 2 9.2 18.6 8.4 7.3 0.1 3.6 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Ureide_permease PF07168.11 CDI78035.1 - 2.1 7.0 9.3 0.59 8.8 1.0 2.5 2 0 0 2 2 2 0 Ureide permease DUF1764 PF08576.10 CDI78035.1 - 2.9 8.8 23.0 1.4 9.9 7.4 3.6 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) DUF4471 PF14740.6 CDI78035.1 - 4.2 6.5 14.6 3.5 6.7 6.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) DUF5523 PF17661.1 CDI78035.1 - 4.9 6.8 29.9 0.19 11.4 10.4 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5523) RPA43_OB PF17875.1 CDI78035.1 - 5.9 7.5 19.3 0.82 10.3 4.5 3.5 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I ART-PolyVal PF18760.1 CDI78035.1 - 6.1 7.9 14.7 0.35 11.9 2.4 2.9 3 0 0 3 3 3 0 ADP-Ribosyltransferase in polyvalent proteins TFIIA PF03153.13 CDI78036.1 - 0.28 11.1 17.0 0.3 11.0 17.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI78036.1 - 0.48 8.9 23.6 0.48 8.9 23.6 1.0 1 0 0 1 1 1 0 Macoilin family Androgen_recep PF02166.16 CDI78036.1 - 0.75 8.6 13.9 0.9 8.3 13.9 1.3 1 0 0 1 1 1 0 Androgen receptor NST1 PF13945.6 CDI78036.1 - 1.5 8.9 22.7 1.7 8.8 22.7 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator PGA2 PF07543.12 CDI78036.1 - 2.4 8.1 6.3 3.1 7.8 6.3 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 MAP65_ASE1 PF03999.12 CDI78036.1 - 3.1 6.4 15.6 3.2 6.3 15.6 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Plasmodium_Vir PF05795.11 CDI78036.1 - 3.8 6.8 16.1 4.2 6.7 16.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Presenilin PF01080.17 CDI78036.1 - 4.8 5.8 16.8 4.6 5.9 16.8 1.0 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 CDI78036.1 - 7.1 6.4 23.9 7.5 6.4 23.9 1.0 1 0 0 1 1 1 0 SPX domain MMU163 PF17119.5 CDI78036.1 - 7.4 5.6 11.1 9.6 5.3 11.1 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Roughex PF06020.11 CDI78036.1 - 9.3 5.2 8.7 9.6 5.2 8.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein PI3K_1B_p101 PF10486.9 CDI78036.1 - 9.7 3.8 14.4 10 3.8 14.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GF_recep_IV PF14843.6 CDI78038.1 - 0.18 11.6 8.7 2.5 7.9 1.0 2.3 2 0 0 2 2 2 0 Growth factor receptor domain IV ADK PF00406.22 CDI78039.1 - 4.6e-30 104.7 0.0 8.4e-14 51.9 0.0 2.5 2 0 0 2 2 2 2 Adenylate kinase EF_TS PF00889.19 CDI78039.1 - 6.2e-26 91.3 0.1 6.4e-25 88.0 0.1 2.6 1 1 0 1 1 1 1 Elongation factor TS AAA_17 PF13207.6 CDI78039.1 - 4.7e-21 75.6 4.9 5.6e-09 36.5 0.0 4.3 5 0 0 5 5 5 2 AAA domain AAA_18 PF13238.6 CDI78039.1 - 1.2e-05 25.8 2.1 0.18 12.3 0.0 3.3 4 0 0 4 4 4 2 AAA domain Cytidylate_kin2 PF13189.6 CDI78039.1 - 0.072 13.2 0.0 6.5 6.9 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase-like family Thymidylate_kin PF02223.17 CDI78039.1 - 1.2 8.8 0.0 1.2 8.8 0.0 3.4 3 1 0 3 3 3 0 Thymidylate kinase UPF0054 PF02130.17 CDI78040.1 - 0.018 14.9 0.5 0.033 14.0 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein family UPF0054 Syntaxin PF00804.25 CDI78040.1 - 0.082 12.6 17.3 0.49 10.0 6.8 2.2 1 1 1 2 2 2 0 Syntaxin JIP_LZII PF16471.5 CDI78040.1 - 0.082 13.1 7.0 0.11 12.7 1.7 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II USP8_interact PF08941.10 CDI78040.1 - 0.096 12.5 8.0 6.6 6.5 0.0 3.1 2 1 1 3 3 3 0 USP8 interacting Occludin_ELL PF07303.13 CDI78040.1 - 0.19 12.5 12.1 2.8 8.7 4.8 3.1 1 1 1 2 2 2 0 Occludin homology domain DUF948 PF06103.11 CDI78040.1 - 0.32 11.3 2.6 2.6 8.4 2.6 2.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) EspB PF05802.11 CDI78040.1 - 0.32 10.9 14.5 1.1 9.2 4.0 2.3 1 1 1 2 2 2 0 Enterobacterial EspB protein V_ATPase_I PF01496.19 CDI78040.1 - 0.72 7.7 11.9 0.83 7.5 11.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LRRC37AB_C PF14914.6 CDI78040.1 - 0.9 9.4 6.8 0.097 12.6 0.7 2.0 1 1 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain DUF1664 PF07889.12 CDI78040.1 - 0.94 9.5 5.1 0.65 10.1 3.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 CDI78040.1 - 1.3 7.8 23.0 0.035 13.0 10.6 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein WDCP PF15390.6 CDI78040.1 - 1.9 6.8 9.8 2.5 6.4 9.8 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SlyX PF04102.12 CDI78040.1 - 2.3 8.9 17.2 0.39 11.4 0.5 4.0 4 1 1 5 5 4 0 SlyX DUF4349 PF14257.6 CDI78040.1 - 2.5 7.5 12.6 2.3 7.6 7.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) Snapin_Pallidin PF14712.6 CDI78040.1 - 3.9 8.0 13.8 0.31 11.5 7.8 2.2 2 2 0 2 2 2 0 Snapin/Pallidin TMF_DNA_bd PF12329.8 CDI78040.1 - 5.8 7.0 20.7 0.24 11.4 3.3 4.0 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding FUSC PF04632.12 CDI78040.1 - 6.4 5.2 9.7 7.6 4.9 9.3 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF2721 PF11026.8 CDI78040.1 - 6.6 6.6 6.3 6 6.8 1.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) CorA PF01544.18 CDI78040.1 - 7.8 5.7 11.0 3.5 6.8 6.8 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Cgr1 PF03879.14 CDI78041.1 - 0.0038 17.6 24.5 0.0071 16.7 24.5 1.4 1 0 0 1 1 1 1 Cgr1 family RNA_polI_A34 PF08208.11 CDI78041.1 - 0.0051 16.9 11.6 0.0097 16.0 11.6 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 AAA_11 PF13086.6 CDI78041.1 - 0.35 10.6 10.4 0.52 10.0 10.4 1.2 1 0 0 1 1 1 0 AAA domain DUF4578 PF15147.6 CDI78041.1 - 0.49 11.3 8.8 0.11 13.4 5.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Hid1 PF12722.7 CDI78041.1 - 1.7 6.6 6.4 2.1 6.4 6.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GIY-YIG PF01541.24 CDI78041.1 - 1.9 8.8 5.1 16 5.8 5.1 2.1 1 1 0 1 1 1 0 GIY-YIG catalytic domain DUF2058 PF09831.9 CDI78041.1 - 2 8.5 18.2 3.5 7.8 18.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Borrelia_P83 PF05262.11 CDI78041.1 - 7.7 4.9 14.5 10 4.5 14.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1993 PF09351.10 CDI78042.1 - 0.028 14.6 4.4 0.04 14.1 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) FlaC_arch PF05377.11 CDI78042.1 - 0.48 10.8 9.7 3 8.3 0.2 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) 5_nucleotid PF05761.14 CDI78042.1 - 0.52 9.1 7.3 0.61 8.9 7.3 1.1 1 0 0 1 1 1 0 5' nucleotidase family Atg14 PF10186.9 CDI78042.1 - 0.73 8.9 18.2 1 8.4 18.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Effector_1 PF04518.12 CDI78042.1 - 0.88 8.6 7.8 10 5.1 7.7 2.0 1 1 0 1 1 1 0 Effector from type III secretion system Spot_14 PF07084.12 CDI78042.1 - 1.2 9.3 8.1 1.1 9.4 7.0 1.5 1 1 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 Exonuc_VII_L PF02601.15 CDI78042.1 - 1.7 8.2 13.0 2.2 7.8 13.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4472 PF14739.6 CDI78042.1 - 1.8 9.3 23.6 1.3 9.8 7.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) DUF932 PF06067.11 CDI78042.1 - 2 8.2 8.8 4.5 7.0 8.9 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF932) BRICHOS PF04089.14 CDI78042.1 - 2.6 8.4 5.6 2.3 8.5 3.7 2.0 1 1 1 2 2 2 0 BRICHOS domain YabA PF06156.13 CDI78042.1 - 2.7 8.7 14.6 12 6.6 1.0 2.3 1 1 1 2 2 2 0 Initiation control protein YabA DUF1664 PF07889.12 CDI78042.1 - 2.8 8.0 12.3 13 5.9 6.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 CDI78042.1 - 2.9 8.1 27.4 2.1 8.5 18.0 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 CDI78042.1 - 3.2 7.0 11.7 4.6 6.5 11.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DHR10 PF18595.1 CDI78042.1 - 3.7 7.6 31.7 0.4 10.8 0.7 3.1 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain DUF2721 PF11026.8 CDI78042.1 - 3.9 7.4 8.8 9.4 6.1 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) Bacillus_HBL PF05791.11 CDI78042.1 - 5.7 6.7 8.9 2.2 8.1 0.3 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Fib_alpha PF08702.10 CDI78042.1 - 7.6 6.7 11.8 5.7 7.1 0.6 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family LNS2 PF08235.13 CDI78044.1 - 5.8e-85 284.3 0.0 8.4e-85 283.8 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_mid PF16876.5 CDI78044.1 - 2.2e-20 72.6 0.0 3.8e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Lipin_N PF04571.14 CDI78044.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 lipin, N-terminal conserved region EF-hand_1 PF00036.32 CDI78045.1 - 6e-15 53.6 0.8 2.4e-07 29.8 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CDI78045.1 - 7.4e-15 53.6 2.6 3.3e-07 29.7 0.2 3.5 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 CDI78045.1 - 1.5e-14 54.2 0.6 9.9e-08 32.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 CDI78045.1 - 1.1e-12 48.1 0.0 1.6e-08 34.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDI78045.1 - 2.8e-09 36.0 0.3 0.0001 21.6 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI78045.1 - 3.3e-06 26.8 1.7 0.00096 18.9 0.3 3.1 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_14 PF17959.1 CDI78045.1 - 0.025 14.9 0.0 8.5 6.8 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Spt20 PF12090.8 CDI78047.1 - 0.026 14.2 0.2 0.026 14.2 0.2 2.8 3 0 0 3 3 3 0 Spt20 family DUF2722 PF10846.8 CDI78047.1 - 0.046 12.7 0.1 0.046 12.7 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDI78047.1 - 2.2 7.2 28.1 0.96 8.3 12.7 2.7 3 0 0 3 3 3 0 Transcriptional activator LAG-3 SUIM_assoc PF16619.5 CDI78047.1 - 6 7.0 31.6 0.22 11.6 5.6 3.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 MPP6 PF10175.9 CDI78047.1 - 8.5 6.9 9.4 1.3 9.5 0.1 2.8 3 0 0 3 3 3 0 M-phase phosphoprotein 6 zf-CCCH PF00642.24 CDI78048.1 - 2.9e-08 33.4 17.1 5.1e-06 26.3 0.8 4.0 3 1 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI78048.1 - 2.1e-06 27.6 13.8 0.025 14.6 0.5 3.8 3 0 0 3 3 3 3 Zinc finger domain Torus PF16131.5 CDI78048.1 - 2.2e-05 25.1 5.5 0.069 13.9 0.0 3.3 2 1 0 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 CDI78048.1 - 0.056 13.3 0.9 0.056 13.3 0.9 3.8 3 1 0 3 3 3 0 CCCH-type zinc finger Robl_LC7 PF03259.17 CDI78048.1 - 0.11 12.2 1.7 0.42 10.4 1.7 2.0 1 0 0 1 1 1 0 Roadblock/LC7 domain MucB_RseB_C PF17188.4 CDI78048.1 - 0.14 12.4 0.1 0.32 11.2 0.1 1.7 1 0 0 1 1 1 0 MucB/RseB C-terminal domain zf-CCCH_3 PF15663.5 CDI78048.1 - 0.45 10.8 8.5 0.19 11.9 3.8 2.5 2 0 0 2 2 2 0 Zinc-finger containing family IQ PF00612.27 CDI78049.1 - 0.0004 19.9 0.2 0.0016 18.0 0.0 2.2 2 0 0 2 2 2 1 IQ calmodulin-binding motif BT1 PF03092.16 CDI78051.1 - 3.9e-64 216.8 24.5 1.3e-52 178.7 14.0 2.1 1 1 1 2 2 2 2 BT1 family LRR_4 PF12799.7 CDI78053.1 - 0.002 18.5 0.1 0.0079 16.6 0.0 2.0 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI78053.1 - 0.17 11.7 1.1 1.9 8.3 0.2 2.3 1 1 1 2 2 2 0 Leucine rich repeat LRR_1 PF00560.33 CDI78053.1 - 2.5 9.0 6.1 13 6.8 0.2 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat Acyltransferase PF01553.21 CDI78055.1 - 2.4e-17 62.8 0.0 3.9e-10 39.5 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase SR-25 PF10500.9 CDI78055.1 - 0.69 9.5 7.0 1.2 8.7 7.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PIH1 PF08190.12 CDI78056.1 - 2e-05 24.2 0.2 0.00075 19.0 0.0 3.5 4 0 0 4 4 4 2 PIH1 N-terminal domain TFIIA PF03153.13 CDI78057.1 - 2.2 8.2 18.4 2.6 7.9 18.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PepSY_2 PF13670.6 CDI78058.1 - 5.5 7.1 5.9 15 5.7 5.9 1.7 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain TRAPPC9-Trs120 PF08626.11 CDI78059.1 - 1.2e-14 52.7 2.9 1.9e-09 35.5 0.0 4.3 5 1 0 5 5 5 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit YojJ PF10372.9 CDI78060.1 - 0.02 15.0 3.2 0.23 11.6 0.7 2.9 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF4746 PF15928.5 CDI78061.1 - 0.0083 15.6 15.2 0.0083 15.6 15.2 4.4 2 2 1 3 3 3 1 Domain of unknown function (DUF4746) Phosphonate-bd PF12974.7 CDI78063.1 - 0.07 12.7 0.2 0.25 10.9 0.2 1.9 1 1 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein SPX PF03105.19 CDI78063.1 - 8.4 6.2 17.0 30 4.4 12.2 2.3 2 0 0 2 2 2 0 SPX domain Apt1 PF10351.9 CDI78063.1 - 8.5 5.1 17.2 3.3 6.4 9.2 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain TFIIA PF03153.13 CDI78064.1 - 0.013 15.5 8.2 0.017 15.2 8.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM247 PF15444.6 CDI78064.1 - 0.22 11.6 2.2 0.34 10.9 2.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 SUIM_assoc PF16619.5 CDI78065.1 - 0.0097 15.9 0.0 0.0097 15.9 0.0 13.2 12 3 1 13 13 13 4 Unstructured region C-term to UIM in Ataxin3 Dehalogenase PF13486.6 CDI78065.1 - 0.71 9.2 3.5 4.9 6.4 0.1 3.0 2 0 0 2 2 2 0 Reductive dehalogenase subunit Brix PF04427.18 CDI78066.1 - 1.2e-30 107.0 0.0 2.5e-30 106.0 0.0 1.5 2 0 0 2 2 2 1 Brix domain TFIIA PF03153.13 CDI78066.1 - 0.67 9.9 24.0 1.1 9.1 24.0 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_10 PF05971.12 CDI78070.1 - 4.1e-58 197.1 7.0 1e-40 140.0 0.2 4.4 3 1 1 4 4 4 3 RNA methyltransferase MTS PF05175.14 CDI78070.1 - 0.061 12.9 0.0 0.061 12.9 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_25 PF13649.6 CDI78070.1 - 0.18 12.5 1.2 0.53 11.0 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain DUF4769 PF15992.5 CDI78070.1 - 4.2 7.1 10.8 0.44 10.3 3.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4769) RskA PF10099.9 CDI78071.1 - 0.015 15.6 8.9 0.015 15.6 8.9 4.9 2 2 2 5 5 5 0 Anti-sigma-K factor rskA DUF4148 PF13663.6 CDI78071.1 - 0.27 11.4 0.1 0.27 11.4 0.1 6.0 4 2 0 4 4 4 0 Domain of unknown function (DUF4148) STIMATE PF12400.8 CDI78072.1 - 3.8e-33 114.7 3.2 4.8e-33 114.4 3.2 1.1 1 0 0 1 1 1 1 STIMATE family DUF3523 PF12037.8 CDI78073.1 - 3.6e-29 101.9 14.3 4.1e-29 101.8 14.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) Wbp11 PF09429.10 CDI78073.1 - 1 9.8 13.8 1.1 9.7 0.1 2.1 1 1 1 2 2 2 0 WW domain binding protein 11 Uteroglobin PF01099.17 CDI78074.1 - 0.18 12.2 1.1 14 6.1 1.0 2.3 2 0 0 2 2 2 0 Uteroglobin family HECT PF00632.25 CDI78075.1 - 1.2e-31 110.4 0.0 3.4e-29 102.3 0.0 2.3 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) SR-25 PF10500.9 CDI78076.1 - 0.0026 17.4 5.4 0.0026 17.4 5.4 11.9 11 2 3 14 14 14 2 Nuclear RNA-splicing-associated protein AKAP7_NLS PF10469.9 CDI78079.1 - 8.8e-38 130.3 0.2 6.6e-37 127.4 0.1 2.3 2 1 0 2 2 2 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 CDI78079.1 - 0.0051 16.7 2.2 0.01 15.7 0.5 2.2 2 1 0 2 2 2 1 2'-5' RNA ligase superfamily TFIIA PF03153.13 CDI78079.1 - 0.0073 16.4 16.2 0.1 12.6 5.7 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI78079.1 - 0.011 15.7 1.1 0.011 15.7 1.1 3.4 3 1 0 3 3 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4228 PF14009.6 CDI78079.1 - 0.042 14.2 5.2 0.37 11.2 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Spt20 PF12090.8 CDI78079.1 - 0.079 12.6 19.0 0.069 12.7 7.1 2.3 2 0 0 2 2 2 0 Spt20 family FAM53 PF15242.6 CDI78079.1 - 0.27 11.0 6.7 0.04 13.7 1.6 2.1 3 0 0 3 3 3 0 Family of FAM53 ig PF00047.25 CDI78079.1 - 0.36 11.0 1.6 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Med3 PF11593.8 CDI78079.1 - 0.77 8.9 13.1 0.78 8.9 6.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal MPM1 PF17234.2 CDI78079.1 - 2.4 8.4 11.1 10 6.3 0.7 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 ARF7EP_C PF14949.6 CDI78079.1 - 6 7.5 8.2 20 5.9 0.9 2.4 2 0 0 2 2 2 0 ARF7 effector protein C-terminus DUF2052 PF09747.9 CDI78080.1 - 7.4 6.6 24.8 0.4 10.8 8.9 2.8 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) OTU PF02338.19 CDI78081.1 - 1.8e-07 31.7 0.0 3.9e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 OTU-like cysteine protease TFIIA PF03153.13 CDI78081.1 - 0.073 13.1 6.5 0.082 12.9 6.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LHH PF14411.6 CDI78081.1 - 0.21 11.8 0.9 0.7 10.1 0.0 2.0 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH Spt20 PF12090.8 CDI78082.1 - 0.0017 18.0 6.4 0.0017 18.0 6.4 4.2 3 1 0 3 3 3 1 Spt20 family DUF2722 PF10846.8 CDI78082.1 - 0.47 9.3 41.9 0.24 10.3 4.2 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) Mito_carr PF00153.27 CDI78083.1 - 2.8e-12 46.4 13.8 1e-05 25.3 0.1 4.7 2 1 1 3 3 3 2 Mitochondrial carrier protein DUF755 PF05501.11 CDI78083.1 - 0.012 15.9 9.8 0.012 15.9 9.8 5.3 4 1 1 5 5 5 0 Domain of unknown function (DUF755) Cwf_Cwc_15 PF04889.12 CDI78083.1 - 0.14 11.8 0.1 0.14 11.8 0.1 3.1 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein DUF3446 PF11928.8 CDI78083.1 - 0.49 10.7 25.8 0.037 14.3 6.0 3.8 3 1 0 3 3 3 0 Early growth response N-terminal domain FB_lectin PF07367.11 CDI78083.1 - 5 7.1 6.0 0.35 10.8 0.8 1.8 2 0 0 2 2 2 0 Fungal fruit body lectin DUF4667 PF15700.5 CDI78083.1 - 8.7 6.4 23.4 0.67 10.0 1.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) RskA PF10099.9 CDI78084.1 - 0.0029 17.9 16.7 0.0029 17.9 16.7 10.0 4 3 4 8 8 5 2 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI78084.1 - 0.18 12.8 0.0 0.18 12.8 0.0 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) Neur_chan_memb PF02932.16 CDI78084.1 - 0.33 11.0 19.4 2.5 8.1 0.5 3.3 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region MID_MedPIWI PF18296.1 CDI78084.1 - 0.35 10.6 23.3 0.91 9.3 7.8 4.1 4 0 0 4 4 4 0 MID domain of medPIWI V_ATPase_I PF01496.19 CDI78084.1 - 0.47 8.3 21.8 0.077 10.9 0.2 2.7 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI78084.1 - 1.9 6.6 43.9 0.45 8.7 24.3 3.2 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CDI78084.1 - 2.5 6.4 4.6 11 4.3 2.6 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF1980 PF09323.10 CDI78084.1 - 2.9 7.8 20.5 0.59 10.0 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) Peptidase_S49_N PF08496.10 CDI78084.1 - 4.1 7.4 25.7 0.89 9.6 9.6 3.5 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DUF572 PF04502.13 CDI78084.1 - 4.7 6.7 22.0 3.6 7.1 8.5 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF572) SpoIIIAH PF12685.7 CDI78084.1 - 5.5 6.8 35.5 0.19 11.5 2.0 4.8 5 0 0 5 5 5 0 SpoIIIAH-like protein BORG_CEP PF14957.6 CDI78084.1 - 6.4 8.0 20.9 12 7.1 6.8 4.1 4 0 0 4 4 4 0 Cdc42 effector Iso_dh PF00180.20 CDI78085.1 - 2.3e-20 73.0 0.0 2.4e-20 73.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-C2HC5 PF06221.13 CDI78086.1 - 0.014 15.4 4.7 0.037 14.0 4.7 1.8 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type V-SNARE_C PF12352.8 CDI78087.1 - 0.00096 19.4 0.5 0.002 18.4 0.5 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 CDI78087.1 - 0.019 15.3 0.3 0.034 14.5 0.3 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DUF2721 PF11026.8 CDI78087.1 - 0.03 14.2 2.6 0.034 14.1 1.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) RskA PF10099.9 CDI78088.1 - 0.0011 19.3 0.0 0.0011 19.3 0.0 6.4 2 2 1 3 3 3 1 Anti-sigma-K factor rskA DUF809 PF05663.11 CDI78088.1 - 8.5 6.5 8.1 17 5.5 8.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF809) CBS PF00571.28 CDI78089.1 - 2.4e-07 31.1 1.2 7.6e-05 23.1 0.1 2.9 3 0 0 3 3 3 1 CBS domain Thg1C PF14413.6 CDI78089.1 - 0.15 12.2 6.2 1.3 9.2 2.1 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain RMP PF14996.6 CDI78089.1 - 0.18 12.0 6.2 1 9.6 0.2 2.2 2 0 0 2 2 2 0 Retinal Maintenance DUF572 PF04502.13 CDI78089.1 - 0.26 10.9 7.3 0.4 10.3 7.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Methyltransf_34 PF11312.8 CDI78089.1 - 0.27 10.4 8.1 0.42 9.8 8.1 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase eIF3g PF12353.8 CDI78089.1 - 0.51 10.7 4.8 4.3 7.7 1.9 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G IHABP4_N PF16174.5 CDI78089.1 - 0.9 10.1 18.2 1.5 9.4 18.2 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal Peroxin-3 PF04882.12 CDI78089.1 - 1.3 8.0 13.5 1.8 7.5 13.5 1.1 1 0 0 1 1 1 0 Peroxin-3 PAT1 PF09770.9 CDI78089.1 - 2.2 6.4 20.7 3 6.0 20.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SAPS PF04499.15 CDI78089.1 - 2.3 6.9 9.1 3 6.5 9.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 CDI78089.1 - 2.4 7.9 14.3 4.1 7.1 14.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 CDI78089.1 - 2.5 7.1 16.8 3.6 6.6 16.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PAS PF00989.25 CDI78089.1 - 2.5 8.1 6.2 1.3 9.0 0.2 2.3 2 0 0 2 2 2 0 PAS fold Draxin PF15550.6 CDI78089.1 - 3 7.6 10.6 4.1 7.2 10.6 1.1 1 0 0 1 1 1 0 Draxin Hid1 PF12722.7 CDI78089.1 - 3.7 5.5 9.7 5.7 4.9 9.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nitroreductase PF00881.24 CDI78089.1 - 4.8 7.2 15.4 3 7.9 4.9 2.4 1 1 1 2 2 2 0 Nitroreductase family GREB1 PF15782.5 CDI78089.1 - 5.4 4.0 12.7 6.7 3.7 12.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cytochrome_C7 PF14522.6 CDI78089.1 - 8.1 6.5 9.5 0.47 10.5 1.7 2.4 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Ndc1_Nup PF09531.10 CDI78089.1 - 8.4 4.9 10.7 12 4.5 10.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.14 CDI78089.1 - 8.9 6.2 17.1 16 5.4 17.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DS PF01916.17 CDI78091.1 - 1.3e-79 267.5 0.0 2e-45 155.3 0.0 2.7 1 1 1 2 2 2 2 Deoxyhypusine synthase MPM1 PF17234.2 CDI78091.1 - 0.027 14.7 2.2 0.027 14.7 2.2 2.7 2 1 1 3 3 3 0 Mitochondrial peculiar membrane protein 1 Presenilin PF01080.17 CDI78091.1 - 0.039 12.7 8.4 0.091 11.5 8.4 1.6 1 0 0 1 1 1 0 Presenilin DUF494 PF04361.13 CDI78091.1 - 0.62 9.9 3.2 0.84 9.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF494) V_ATPase_I PF01496.19 CDI78091.1 - 0.63 7.9 5.8 0.93 7.3 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family XRN_M PF17846.1 CDI78091.1 - 1.9 7.4 6.9 3.2 6.6 6.9 1.3 1 0 0 1 1 1 0 Xrn1 helical domain SLC12 PF03522.15 CDI78091.1 - 2.6 6.9 9.2 4.5 6.2 9.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Pex14_N PF04695.13 CDI78091.1 - 5.1 7.7 27.5 0.027 15.1 6.2 3.9 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4820 PF16091.5 CDI78091.1 - 9 5.6 11.2 24 4.2 11.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) AAA PF00004.29 CDI78092.1 - 7.9e-73 243.1 0.4 7.5e-45 152.6 0.0 5.0 3 1 1 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI78092.1 - 3.2e-14 52.5 5.9 2.7e-09 36.7 0.1 2.9 3 0 0 3 3 2 2 AAA+ lid domain RuvB_N PF05496.12 CDI78092.1 - 1.5e-08 34.6 0.0 0.0035 17.1 0.0 3.4 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDI78092.1 - 8.1e-07 29.1 0.0 0.077 13.0 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDI78092.1 - 3.9e-06 27.1 4.8 0.27 11.4 0.0 5.6 4 1 0 4 4 3 2 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 CDI78092.1 - 1.4e-05 25.4 0.0 0.093 13.1 0.0 3.0 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 CDI78092.1 - 2.4e-05 23.8 0.8 0.23 10.8 0.0 3.4 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 CDI78092.1 - 5e-05 22.6 0.9 0.53 9.4 0.0 3.7 3 0 0 3 3 3 1 Protein of unknown function (DUF815) TIP49 PF06068.13 CDI78092.1 - 5.8e-05 22.5 0.0 0.0078 15.5 0.0 2.4 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 CDI78092.1 - 7.6e-05 22.5 1.7 0.093 12.5 0.0 3.6 4 0 0 4 4 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 CDI78092.1 - 0.00015 21.8 0.0 1.9 8.5 0.0 3.9 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CDI78092.1 - 0.00027 21.4 15.4 0.00051 20.5 13.2 6.7 4 3 2 6 6 5 2 AAA ATPase domain AAA_19 PF13245.6 CDI78092.1 - 0.0008 19.8 6.7 0.054 13.8 5.5 3.5 2 1 0 2 2 2 1 AAA domain RskA PF10099.9 CDI78092.1 - 0.00086 19.6 8.8 0.00086 19.6 8.8 9.6 4 3 1 5 5 1 1 Anti-sigma-K factor rskA AAA_3 PF07726.11 CDI78092.1 - 0.00091 19.1 0.0 0.59 10.0 0.0 3.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CDI78092.1 - 0.0015 18.5 0.0 0.44 10.4 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 CDI78092.1 - 0.0015 18.1 0.0 0.82 9.2 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 CDI78092.1 - 0.0037 17.5 23.3 0.02 15.2 0.5 6.4 4 2 2 7 7 6 2 AAA domain DUF2722 PF10846.8 CDI78092.1 - 0.004 16.2 9.3 0.004 16.2 9.3 8.9 6 3 1 7 7 2 2 Protein of unknown function (DUF2722) Bac_DnaA PF00308.18 CDI78092.1 - 0.0042 17.0 0.1 0.17 11.7 0.0 2.9 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_25 PF13481.6 CDI78092.1 - 0.0046 16.6 0.1 15 5.1 0.0 3.7 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 CDI78092.1 - 0.012 15.6 0.0 3.5 7.5 0.0 3.4 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CDI78092.1 - 0.012 15.6 0.0 3.5 7.7 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 CDI78092.1 - 0.028 13.8 0.0 33 3.7 0.0 3.4 3 0 0 3 3 3 0 KaiC AAA_18 PF13238.6 CDI78092.1 - 0.037 14.6 1.5 0.6 10.7 0.0 3.4 4 0 0 4 4 2 0 AAA domain AAA_24 PF13479.6 CDI78092.1 - 0.043 13.6 0.0 0.043 13.6 0.0 3.3 4 0 0 4 4 2 0 AAA domain AAA_33 PF13671.6 CDI78092.1 - 4 7.6 36.1 0.45 10.7 1.1 5.8 5 2 1 6 6 5 0 AAA domain SR-25 PF10500.9 CDI78093.1 - 0.017 14.7 7.2 0.023 14.3 7.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4680 PF15730.5 CDI78093.1 - 0.46 10.8 5.1 0.8 10.0 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) CDC45 PF02724.14 CDI78094.1 - 0.0011 17.4 8.6 0.0011 17.4 8.6 6.0 5 1 1 7 7 7 1 CDC45-like protein Gar1 PF04410.14 CDI78094.1 - 0.0021 17.8 0.1 0.0021 17.8 0.1 4.1 3 1 1 4 4 4 1 Gar1/Naf1 RNA binding region SpoIIIAH PF12685.7 CDI78094.1 - 0.021 14.7 0.1 0.021 14.7 0.1 9.8 7 5 1 8 8 8 0 SpoIIIAH-like protein SUIM_assoc PF16619.5 CDI78095.1 - 0.0007 19.6 0.3 1.1 9.4 0.0 2.6 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Dimer_Tnp_hAT PF05699.14 CDI78095.1 - 0.091 12.6 0.5 3.1 7.7 0.2 2.5 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Drc1-Sld2 PF11719.8 CDI78096.1 - 5.6 6.4 48.8 0.74 9.3 8.4 3.1 2 1 1 3 3 3 0 DNA replication and checkpoint protein O-antigen_lig PF13425.6 CDI78098.1 - 0.042 12.6 0.0 0.25 10.1 0.0 1.9 2 0 0 2 2 2 0 O-antigen ligase like membrane protein V_ATPase_I PF01496.19 CDI78098.1 - 0.86 7.4 9.4 1.8 6.4 0.3 2.8 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family PHO4 PF01384.20 CDI78101.1 - 0.027 13.5 6.4 0.045 12.8 6.4 1.3 1 0 0 1 1 1 0 Phosphate transporter family DUF4257 PF14074.6 CDI78101.1 - 1.8 8.8 6.5 7.2 6.9 0.6 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF4257) DUF2613 PF11021.8 CDI78101.1 - 5 7.3 5.8 6.7 6.9 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) DUF3382 PF11862.8 CDI78101.1 - 10 6.5 13.6 7.7 6.9 0.1 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3382) TFIIA PF03153.13 CDI78102.1 - 0.19 11.7 34.4 0.059 13.4 4.9 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Myosin_head PF00063.21 CDI78104.1 - 7.2e-35 120.3 0.2 3.7e-22 78.4 0.0 2.4 2 1 0 2 2 2 2 Myosin head (motor domain) AAA_22 PF13401.6 CDI78104.1 - 0.034 14.4 0.2 0.12 12.6 0.2 2.0 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDI78104.1 - 0.04 13.2 0.0 0.1 11.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 CDI78104.1 - 0.16 11.9 0.1 0.39 10.7 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CDI78104.1 - 0.61 10.5 4.7 0.71 10.2 0.3 2.8 1 1 2 3 3 3 0 AAA ATPase domain Presenilin PF01080.17 CDI78109.1 - 0.12 11.1 43.5 0.16 10.7 43.5 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI78109.1 - 0.46 8.7 35.7 0.54 8.5 35.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PNISR PF15996.5 CDI78109.1 - 1.1 9.5 45.1 1.2 9.4 45.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4045 PF13254.6 CDI78109.1 - 2.2 7.8 34.7 2.6 7.6 34.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ALMT PF11744.8 CDI78109.1 - 3 6.6 32.2 3.6 6.3 32.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_11 PF13086.6 CDI78109.1 - 3.2 7.5 36.2 4.9 6.8 36.2 1.3 1 0 0 1 1 1 0 AAA domain SRP-alpha_N PF04086.13 CDI78109.1 - 3.2 7.6 34.0 4.1 7.3 34.0 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal LAP1C PF05609.12 CDI78109.1 - 3.5 6.6 42.2 4.4 6.3 42.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF572 PF04502.13 CDI78109.1 - 4.7 6.7 34.4 5.8 6.4 34.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SLC12 PF03522.15 CDI78109.1 - 7.4 5.5 43.4 8.2 5.3 43.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sec1 PF00995.23 CDI78112.1 - 2.1e-48 165.9 30.1 2.6e-24 86.4 12.0 3.0 1 1 2 3 3 3 3 Sec1 family Glyco_trans_4_3 PF12000.8 CDI78112.1 - 0.15 11.7 3.8 2.2 7.9 0.7 2.7 2 1 0 2 2 2 0 Glycosyl transferase family 4 group Oxygenase-NA PF09859.9 CDI78114.1 - 0.068 12.7 0.0 0.61 9.6 0.0 2.2 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA SPOC PF07744.13 CDI78114.1 - 0.1 12.5 0.0 1.5 8.7 0.0 2.4 3 0 0 3 3 3 0 SPOC domain RP1-2 PF12042.8 CDI78117.1 - 0.02 14.8 1.4 0.038 13.9 1.4 1.4 1 0 0 1 1 1 0 Tubuliform egg casing silk strands structural domain Mt_ATP-synt_B PF05405.14 CDI78117.1 - 0.061 13.0 1.1 0.31 10.6 0.1 2.3 3 0 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) AP2 PF00847.20 CDI78123.1 - 0.023 14.9 0.0 0.023 14.9 0.0 4.3 5 0 0 5 5 5 0 AP2 domain DDHD PF02862.17 CDI78123.1 - 0.055 13.6 3.2 0.46 10.6 1.1 2.3 2 0 0 2 2 2 0 DDHD domain DUF5427 PF10310.9 CDI78123.1 - 3.8 6.4 19.5 0.24 10.3 8.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Presenilin PF01080.17 CDI78123.1 - 4.5 5.9 14.2 0.039 12.7 1.4 2.1 2 0 0 2 2 2 0 Presenilin Spt20 PF12090.8 CDI78123.1 - 4.5 6.8 38.2 0.44 10.1 18.6 2.5 2 0 0 2 2 2 0 Spt20 family EPL1 PF10513.9 CDI78123.1 - 6.8 7.1 14.5 7.5 6.9 6.2 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like TERB2 PF15101.6 CDI78123.1 - 9.7 6.2 18.5 0.88 9.6 7.2 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 tRNA_lig_CPD PF08302.11 CDI78125.1 - 0.37 10.2 4.4 0.94 8.9 0.0 2.4 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain DAGK_acc PF00609.19 CDI78126.1 - 3.5e-15 56.7 0.4 1.5e-12 48.1 0.3 2.3 1 1 1 2 2 2 2 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 CDI78126.1 - 4.3e-15 55.4 0.0 1.6e-14 53.6 0.0 1.9 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ycf4 PF02392.16 CDI78126.1 - 0.091 12.3 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Ycf4 Pkinase_Tyr PF07714.17 CDI78128.1 - 3.2e-49 167.5 0.0 7.2e-46 156.6 0.0 3.5 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 CDI78128.1 - 6.1e-48 163.5 0.0 6.9e-46 156.8 0.0 3.6 3 1 0 3 3 3 1 Protein kinase domain MORN PF02493.20 CDI78128.1 - 2.8e-06 26.9 24.8 0.00082 19.1 1.8 4.7 4 0 0 4 4 4 2 MORN repeat SAM_1 PF00536.30 CDI78128.1 - 0.00061 20.2 0.3 0.0012 19.2 0.3 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDI78128.1 - 0.00079 19.5 0.2 0.0016 18.5 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1754 PF08555.10 CDI78129.1 - 8.2e-05 23.3 22.7 5.1 8.0 22.7 2.6 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Pex16 PF08610.10 CDI78129.1 - 0.094 11.9 2.0 0.14 11.3 2.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Bcl-2_BAD PF10514.9 CDI78129.1 - 0.17 12.4 6.3 0.26 11.8 6.3 1.3 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD Neur_chan_memb PF02932.16 CDI78129.1 - 6.3 6.8 4.8 8.8 6.3 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Bax1-I PF01027.20 CDI78130.1 - 9.1e-32 110.6 22.0 1.1e-31 110.3 22.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF1980 PF09323.10 CDI78130.1 - 0.76 9.7 3.9 0.45 10.4 1.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) CwfJ_C_2 PF04676.14 CDI78131.1 - 1.9e-19 70.3 0.0 1.9e-19 70.3 0.0 2.2 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 CDI78131.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 AP3D1 PF06375.11 CDI78131.1 - 0.0071 16.6 7.5 0.0071 16.6 7.5 2.9 3 0 0 3 3 3 1 AP-3 complex subunit delta-1 ATPase PF06745.13 CDI78131.1 - 0.053 12.9 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 KaiC Macoilin PF09726.9 CDI78131.1 - 0.52 8.8 37.7 0.3 9.6 18.8 2.4 2 0 0 2 2 2 0 Macoilin family APC_15aa PF05972.11 CDI78131.1 - 1.4 9.3 4.5 0.35 11.2 1.3 1.8 2 0 0 2 2 2 0 APC 15 residue motif Peptidase_S49_N PF08496.10 CDI78131.1 - 2.1 8.4 6.1 7.6 6.6 6.1 1.9 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RskA PF10099.9 CDI78132.1 - 0.0013 19.1 9.7 0.0013 19.1 9.7 12.6 2 2 6 8 8 8 1 Anti-sigma-K factor rskA Caldesmon PF02029.15 CDI78133.1 - 0.15 10.8 27.7 0.25 10.1 27.7 1.3 1 0 0 1 1 1 0 Caldesmon MPM1 PF17234.2 CDI78133.1 - 0.18 12.1 31.8 0.59 10.4 10.2 3.0 3 0 0 3 3 3 0 Mitochondrial peculiar membrane protein 1 YfhO PF09586.10 CDI78133.1 - 0.56 8.4 11.4 0.9 7.7 11.4 1.4 1 0 0 1 1 1 0 Bacterial membrane protein YfhO LMBR1 PF04791.16 CDI78133.1 - 0.62 8.9 14.0 0.056 12.4 2.4 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein CPSF100_C PF13299.6 CDI78133.1 - 1.5 9.0 22.4 0.18 12.0 3.0 2.8 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal FAM76 PF16046.5 CDI78133.1 - 1.8 7.8 33.3 1.4 8.2 11.6 2.1 2 0 0 2 2 2 0 FAM76 protein DUF913 PF06025.12 CDI78133.1 - 2.7 6.9 16.5 3.3 6.6 5.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PAT1 PF09770.9 CDI78133.1 - 2.9 6.1 52.4 0.064 11.5 12.9 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SpoIIIAH PF12685.7 CDI78133.1 - 3 7.6 22.7 0.1 12.4 16.7 1.7 2 0 0 2 2 2 0 SpoIIIAH-like protein CD20 PF04103.15 CDI78133.1 - 3 7.9 0.0 3 7.9 0.0 2.7 3 1 0 3 3 3 0 CD20-like family MCM3AP_GANP PF16769.5 CDI78133.1 - 6.8 4.8 34.0 0.44 8.7 9.9 2.1 2 0 0 2 2 2 0 MCM3AP domain of GANP DUF1943 PF09172.11 CDI78133.1 - 8.1 5.6 17.9 0.65 9.2 5.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) MFS_1 PF07690.16 CDI78137.1 - 1.8e-16 60.0 21.6 1.2e-15 57.3 21.2 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily UPF0060 PF02694.15 CDI78137.1 - 0.011 15.9 1.1 0.011 15.9 1.1 3.5 3 1 1 4 4 4 0 Uncharacterised BCR, YnfA/UPF0060 family PulG PF11773.8 CDI78137.1 - 0.12 12.2 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin DAD PF02109.16 CDI78137.1 - 0.45 10.8 8.2 0.2 12.0 4.3 2.5 2 1 0 2 2 2 0 DAD family NEMP PF10225.9 CDI78137.1 - 7.3 6.2 15.9 0.067 12.8 6.9 2.1 2 0 0 2 2 2 0 NEMP family TMEM100 PF16311.5 CDI78137.1 - 8.8 5.9 5.4 1.4 8.5 0.0 2.4 3 0 0 3 3 3 0 Transmembrane protein 100 DUF4148 PF13663.6 CDI78140.1 - 4.2 7.6 26.9 3.6 7.8 1.1 6.2 6 0 0 6 6 6 0 Domain of unknown function (DUF4148) Ribosomal_L27A PF00828.19 CDI78141.1 - 4e-06 27.5 0.0 1e-05 26.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF2722 PF10846.8 CDI78141.1 - 0.0059 15.6 2.4 0.0059 15.6 2.4 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF2722) ABC2_membrane_3 PF12698.7 CDI78141.1 - 0.0062 15.7 0.1 0.012 14.7 0.1 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein MecA PF05389.12 CDI78141.1 - 0.14 11.7 11.1 0.2 11.3 0.5 2.7 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) CNDH2_C PF16858.5 CDI78141.1 - 0.82 9.5 21.3 0.033 14.1 8.0 2.8 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Lig_chan PF00060.26 CDI78141.1 - 1.2 9.0 6.8 0.49 10.2 0.4 2.4 2 0 0 2 2 2 0 Ligand-gated ion channel LMBR1 PF04791.16 CDI78141.1 - 1.6 7.5 7.5 0.37 9.6 1.2 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF1645 PF07816.11 CDI78141.1 - 1.7 9.2 18.4 9.2 6.8 14.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1645) AAA_23 PF13476.6 CDI78141.1 - 2.1 8.8 21.3 0.94 9.9 6.9 3.1 3 0 0 3 3 3 0 AAA domain DUF1644 PF07800.12 CDI78141.1 - 2.1 8.4 13.6 0.32 11.1 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1644) RPA43_OB PF17875.1 CDI78141.1 - 3.1 8.5 7.8 3.9 8.1 0.2 3.0 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I Connexin PF00029.19 CDI78141.1 - 3.4 7.4 11.8 0.36 10.6 1.6 2.5 3 0 0 3 3 3 0 Connexin Peroxin-13_N PF04088.13 CDI78141.1 - 8.5 6.6 14.7 0.82 9.9 2.6 3.0 3 0 0 3 3 3 0 Peroxin 13, N-terminal region RICTOR_N PF14664.6 CDI78141.1 - 8.8 5.2 9.3 2.6 7.0 1.1 2.3 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Exo_endo_phos PF03372.23 CDI78142.1 - 9e-12 45.0 0.0 2.4e-11 43.6 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DAHP_synth_2 PF01474.16 CDI78146.1 - 2.1e-40 138.6 0.0 2.8e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Class-II DAHP synthetase family DAHP_synth_2 PF01474.16 CDI78147.1 - 3.2e-36 124.8 0.0 3.7e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Thioredoxin PF00085.20 CDI78148.1 - 1.2e-06 28.4 0.0 2.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDI78148.1 - 0.07 13.6 0.6 0.14 12.6 0.1 1.8 2 1 0 2 2 2 0 Thioredoxin-like domain DUF2052 PF09747.9 CDI78149.1 - 2.1e-05 24.7 3.4 2.1e-05 24.7 3.4 4.7 4 1 0 4 4 4 1 Coiled-coil domain containing protein (DUF2052) DUF2722 PF10846.8 CDI78149.1 - 0.00011 21.4 22.7 0.00029 19.9 7.7 7.2 5 2 2 7 7 7 3 Protein of unknown function (DUF2722) RskA PF10099.9 CDI78149.1 - 0.00037 20.8 6.8 0.00037 20.8 6.8 10.4 3 2 5 9 9 9 1 Anti-sigma-K factor rskA FHA PF00498.26 CDI78149.1 - 0.00037 20.8 0.0 0.001 19.4 0.0 1.7 1 0 0 1 1 1 1 FHA domain Gti1_Pac2 PF09729.9 CDI78149.1 - 0.004 17.3 1.7 0.004 17.3 1.7 4.8 3 1 0 3 3 3 1 Gti1/Pac2 family Presenilin PF01080.17 CDI78149.1 - 0.021 13.6 73.0 0.022 13.6 19.3 4.3 4 0 0 4 4 4 0 Presenilin Eapp_C PF10238.9 CDI78149.1 - 0.095 12.8 57.9 0.36 10.9 2.8 6.7 6 0 0 6 6 6 0 E2F-associated phosphoprotein N6_N4_Mtase PF01555.18 CDI78149.1 - 0.13 12.0 0.0 67 3.1 0.0 3.6 4 2 0 4 4 4 0 DNA methylase SLC12 PF03522.15 CDI78149.1 - 4.9 6.1 62.7 0.64 9.0 10.6 4.1 4 0 0 4 4 4 0 Solute carrier family 12 ATP-synt PF00231.19 CDI78150.1 - 1.9e-48 165.6 0.1 3.5e-13 49.9 0.0 4.0 1 1 3 4 4 4 4 ATP synthase DUF3669 PF12417.8 CDI78150.1 - 0.036 14.3 0.1 15 5.8 0.0 2.4 2 0 0 2 2 2 0 Zinc finger protein S19 PF06756.11 CDI78150.1 - 0.054 13.4 0.2 13 5.8 0.0 2.3 2 0 0 2 2 2 0 Chorion protein S19 C-terminal Brr6_like_C_C PF10104.9 CDI78150.1 - 0.066 13.0 0.0 14 5.5 0.0 2.3 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain DUF2922 PF11148.8 CDI78150.1 - 0.067 12.9 0.1 14 5.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) TFIIA PF03153.13 CDI78151.1 - 0.0018 18.3 7.0 0.0018 18.3 7.0 2.8 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit XRN_N PF03159.18 CDI78151.1 - 0.0043 16.5 1.5 0.0043 16.5 1.5 2.7 2 1 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus ATP11 PF06644.11 CDI78151.1 - 0.012 15.5 3.1 0.012 15.5 3.1 3.7 3 1 0 3 3 3 0 ATP11 protein Utp14 PF04615.13 CDI78151.1 - 0.046 12.3 24.9 0.092 11.3 25.0 1.3 1 1 0 1 1 1 0 Utp14 protein SLC12 PF03522.15 CDI78151.1 - 0.61 9.0 25.5 0.98 8.4 1.4 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Caldesmon PF02029.15 CDI78151.1 - 4.1 6.1 36.6 4.3 6.0 22.6 2.1 2 0 0 2 2 2 0 Caldesmon CRAL_TRIO PF00650.20 CDI78151.1 - 5.9 6.6 7.7 0.18 11.5 0.3 2.2 2 1 0 2 2 2 0 CRAL/TRIO domain SART-1 PF03343.13 CDI78151.1 - 9 4.7 35.1 1.6 7.2 5.7 2.1 2 0 0 2 2 2 0 SART-1 family SUIM_assoc PF16619.5 CDI78152.1 - 0.00072 19.6 1.2 0.00072 19.6 1.2 4.3 2 1 2 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 Sld5 PF05916.11 CDI78152.1 - 0.0079 16.6 0.7 0.0079 16.6 0.7 2.8 2 2 1 3 3 3 1 GINS complex protein Afi1 PF07792.12 CDI78152.1 - 0.077 13.5 13.9 0.72 10.3 11.2 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking LMBR1 PF04791.16 CDI78152.1 - 0.66 8.8 6.4 0.7 8.7 6.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Pex14_N PF04695.13 CDI78152.1 - 2.9 8.5 27.8 10 6.7 23.6 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pal1 PF08316.11 CDI78152.1 - 5.7 7.7 9.6 71 4.2 9.4 2.1 2 0 0 2 2 2 0 Pal1 cell morphology protein SAE2 PF08573.10 CDI78152.1 - 6 8.0 21.7 1.6 9.9 1.9 2.3 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Exo_endo_phos PF03372.23 CDI78153.1 - 0.016 14.7 1.2 0.053 13.0 0.0 2.6 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family SUIM_assoc PF16619.5 CDI78153.1 - 0.033 14.2 0.0 0.033 14.2 0.0 18.2 7 6 1 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 EBP50_C PF09007.11 CDI78154.1 - 0.024 15.6 0.2 0.88 10.6 0.0 2.1 2 0 0 2 2 2 0 EBP50, C-terminal CDP-OH_P_transf PF01066.21 CDI78155.1 - 9e-09 36.0 2.7 3e-08 34.3 2.7 2.0 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase TFIIA PF03153.13 CDI78155.1 - 0.006 16.6 33.3 0.006 16.6 33.3 3.2 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 CDI78155.1 - 1.7 7.2 11.9 2.7 6.6 11.9 1.2 1 0 0 1 1 1 0 Hamartin protein SpoIIP PF07454.11 CDI78155.1 - 1.9 7.9 6.3 2.7 7.4 6.3 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 CDI78155.1 - 3.3 7.3 29.9 0.25 10.9 21.8 2.2 2 0 0 2 2 2 0 Spt20 family Neur_chan_memb PF02932.16 CDI78155.1 - 4 7.4 6.0 9.1 6.3 6.0 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2722 PF10846.8 CDI78155.1 - 5 6.0 19.4 0.05 12.6 11.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) KH_1 PF00013.29 CDI78156.1 - 1.3e-30 105.0 2.6 1.4e-14 53.7 0.3 3.3 3 0 0 3 3 3 2 KH domain KH_2 PF07650.17 CDI78156.1 - 6.7e-09 35.5 0.3 0.00029 20.6 0.1 2.8 3 0 0 3 3 3 2 KH domain Spt20 PF12090.8 CDI78156.1 - 3e-05 23.7 21.7 3e-05 23.7 21.7 2.2 2 0 0 2 2 2 1 Spt20 family KH_4 PF13083.6 CDI78156.1 - 0.00039 20.2 0.5 0.3 11.0 0.2 3.3 3 0 0 3 3 3 1 KH domain KH_5 PF13184.6 CDI78156.1 - 0.0016 18.5 1.2 1.1 9.4 0.4 2.5 2 0 0 2 2 2 1 NusA-like KH domain TERB2 PF15101.6 CDI78156.1 - 0.0026 17.8 8.5 0.0026 17.8 8.5 2.2 2 0 0 2 2 2 1 Telomere-associated protein TERB2 MMR1 PF08505.10 CDI78156.1 - 0.0037 17.6 10.0 0.0037 17.6 10.0 2.2 2 0 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein RskA PF10099.9 CDI78156.1 - 0.017 15.4 15.7 0.42 10.9 4.7 2.5 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI78156.1 - 0.025 15.3 11.2 0.025 15.3 11.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 CDI78156.1 - 0.027 15.4 13.5 0.35 11.9 10.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EOS1 PF12326.8 CDI78156.1 - 0.029 14.3 2.2 0.052 13.5 1.1 1.8 2 0 0 2 2 2 0 N-glycosylation protein INSIG PF07281.12 CDI78156.1 - 0.089 12.4 0.4 0.35 10.5 0.2 2.0 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) SpoIIP PF07454.11 CDI78156.1 - 0.099 12.1 9.9 0.021 14.3 5.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Rxt3 PF08642.10 CDI78156.1 - 0.22 12.3 4.4 0.88 10.3 3.3 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 EPL1 PF10513.9 CDI78156.1 - 0.24 11.7 14.1 0.094 13.1 8.0 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF4366 PF14283.6 CDI78156.1 - 0.25 11.4 6.7 0.29 11.2 5.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) PRC2_HTH_1 PF18118.1 CDI78156.1 - 0.29 12.0 10.4 0.084 13.7 6.2 2.0 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain DUF2407 PF10302.9 CDI78156.1 - 0.31 11.6 3.5 2 9.0 1.9 2.5 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Cytochrom_B558a PF05038.13 CDI78156.1 - 0.4 10.2 4.0 2 8.0 2.8 2.2 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit CAML PF14963.6 CDI78156.1 - 1.1 9.3 4.2 1.9 8.5 4.2 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand PepSY_TM PF03929.16 CDI78156.1 - 1.3 8.6 6.7 0.74 9.4 3.6 1.9 2 0 0 2 2 2 0 PepSY-associated TM region SLC12 PF03522.15 CDI78156.1 - 1.5 7.8 11.1 0.69 8.9 8.3 1.7 2 0 0 2 2 2 0 Solute carrier family 12 DUF4770 PF15994.5 CDI78156.1 - 1.8 8.8 16.4 0.25 11.6 8.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Auxin_canalis PF05703.11 CDI78156.1 - 1.9 8.3 10.5 0.079 12.9 5.0 1.5 2 0 0 2 2 1 0 Auxin canalisation FAM176 PF14851.6 CDI78156.1 - 2 8.1 5.2 4.8 6.8 4.2 2.0 2 0 0 2 2 2 0 FAM176 family DUF3464 PF11947.8 CDI78156.1 - 2 8.1 13.5 17 5.2 11.8 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 eIF-3_zeta PF05091.12 CDI78156.1 - 2.1 7.2 14.1 0.47 9.4 9.2 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) HA2 PF04408.23 CDI78156.1 - 2.6 8.4 5.6 4.9 7.5 2.2 2.4 2 1 0 2 2 2 0 Helicase associated domain (HA2) HNOBA PF07701.14 CDI78156.1 - 2.8 7.3 11.9 0.046 13.1 2.6 2.0 2 0 0 2 2 2 0 Heme NO binding associated Dicty_REP PF05086.12 CDI78156.1 - 3.3 5.6 6.3 4.5 5.1 6.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein V_ATPase_I PF01496.19 CDI78156.1 - 3.4 5.5 9.3 0.24 9.2 4.2 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PTPRCAP PF15713.5 CDI78156.1 - 3.5 7.9 16.3 0.045 14.0 7.0 2.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF702 PF05142.12 CDI78156.1 - 3.5 8.1 16.6 0.69 10.4 7.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF702) CNDH2_N PF06278.11 CDI78156.1 - 3.6 7.8 11.9 2 8.6 6.1 2.5 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF1980 PF09323.10 CDI78156.1 - 4 7.3 7.5 2.6 7.9 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Conotoxin PF02950.17 CDI78156.1 - 5.1 8.2 8.2 32 5.6 4.5 2.6 2 0 0 2 2 2 0 Conotoxin Peptidase_S64 PF08192.11 CDI78156.1 - 5.7 5.3 13.0 2.3 6.6 7.9 2.0 2 0 0 2 2 2 0 Peptidase family S64 OATP PF03137.20 CDI78156.1 - 6.1 5.0 7.5 0.4 8.9 2.5 1.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family LIM_bind PF01803.16 CDI78156.1 - 6.7 6.2 13.7 3.9 6.9 8.8 2.1 2 0 0 2 2 2 0 LIM-domain binding protein Lin-8 PF03353.15 CDI78156.1 - 7.2 6.1 18.8 0.38 10.3 10.9 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DASH_Spc34 PF08657.10 CDI78156.1 - 7.3 6.3 16.9 0.93 9.2 10.8 2.1 2 0 0 2 2 2 0 DASH complex subunit Spc34 MPM1 PF17234.2 CDI78156.1 - 7.5 6.8 17.7 1.9 8.7 10.9 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Connexin PF00029.19 CDI78156.1 - 7.6 6.2 8.3 1.7 8.4 4.5 1.7 2 0 0 2 2 2 0 Connexin DUF1387 PF07139.11 CDI78156.1 - 8.2 6.1 16.2 0.064 13.0 7.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) Eapp_C PF10238.9 CDI78156.1 - 9.7 6.3 13.1 1.6 8.8 7.4 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein RNR_Alpha PF17975.1 CDI78156.1 - 9.9 6.7 7.6 0.48 11.0 1.1 2.0 2 0 0 2 2 1 0 Ribonucleotide reductase alpha domain PIP5K PF01504.18 CDI78157.1 - 1.4e-60 204.9 0.0 1.6e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DsbC_N PF10411.9 CDI78157.1 - 0.031 13.7 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus CDC45 PF02724.14 CDI78158.1 - 1.3 7.2 20.8 2.1 6.6 0.9 2.4 2 0 0 2 2 2 0 CDC45-like protein BRICHOS PF04089.14 CDI78158.1 - 1.4 9.2 0.0 1.4 9.2 0.0 4.8 4 1 0 4 4 4 0 BRICHOS domain PIG-U PF06728.13 CDI78159.1 - 1.2e-32 113.5 6.1 2.5e-21 76.2 3.9 2.2 1 1 1 2 2 2 2 GPI transamidase subunit PIG-U Connexin PF00029.19 CDI78159.1 - 8.3e-05 22.5 0.8 0.00078 19.3 0.0 2.2 2 0 0 2 2 2 1 Connexin DUF1616 PF07760.11 CDI78159.1 - 0.0036 16.8 2.2 0.13 11.7 0.3 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1616) DDHD PF02862.17 CDI78159.1 - 0.0041 17.3 1.6 0.01 16.0 0.1 1.9 2 0 0 2 2 2 1 DDHD domain baeRF_family10 PF18854.1 CDI78159.1 - 0.0077 16.5 4.5 0.0077 16.5 4.5 1.7 2 0 0 2 2 1 1 Bacterial archaeo-eukaryotic release factor family 10 DUF2207 PF09972.9 CDI78159.1 - 0.0096 14.7 0.0 0.017 13.9 0.0 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Velvet PF11754.8 CDI78159.1 - 0.011 15.7 0.5 0.011 15.7 0.5 2.0 2 0 0 2 2 2 0 Velvet factor Pex14_N PF04695.13 CDI78159.1 - 0.011 16.4 7.2 0.011 16.4 7.2 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMU163 PF17119.5 CDI78159.1 - 0.19 10.8 1.3 0.43 9.7 1.3 1.5 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis EMC3_TMCO1 PF01956.16 CDI78159.1 - 0.35 10.6 4.6 0.63 9.8 0.1 2.4 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Ureide_permease PF07168.11 CDI78159.1 - 0.62 8.7 9.1 6.4 5.4 0.0 2.5 2 1 0 2 2 2 0 Ureide permease Peptidase_S49_N PF08496.10 CDI78159.1 - 0.7 9.9 10.2 0.21 11.6 3.3 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FAM199X PF15814.5 CDI78159.1 - 0.75 8.8 12.7 8.9 5.3 0.0 2.6 2 1 0 2 2 2 0 Protein family FAM199X MCU PF04678.13 CDI78159.1 - 0.85 9.7 10.1 2 8.5 3.8 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Presenilin PF01080.17 CDI78159.1 - 1.5 7.5 9.6 0.09 11.5 3.1 2.1 2 0 0 2 2 2 0 Presenilin DUF1980 PF09323.10 CDI78159.1 - 2 8.3 6.3 16 5.4 3.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) ExbD PF02472.16 CDI78159.1 - 2.4 8.3 7.9 0.18 12.0 2.0 2.0 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR Neur_chan_memb PF02932.16 CDI78159.1 - 2.7 8.0 6.5 0.45 10.5 1.1 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CemA PF03040.14 CDI78159.1 - 3.3 7.6 7.3 2.7 7.9 2.7 2.2 2 0 0 2 2 2 0 CemA family OmpH PF03938.14 CDI78159.1 - 3.7 7.9 42.4 0.14 12.5 21.2 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TFIIA PF03153.13 CDI78159.1 - 3.9 7.4 38.3 0.31 11.0 20.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AIF_C PF14721.6 CDI78159.1 - 4 7.8 6.3 0.63 10.4 0.9 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Peptidase_S15 PF02129.18 CDI78159.1 - 4.5 6.8 9.2 1.1 8.8 3.6 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) SprA-related PF12118.8 CDI78159.1 - 5 6.2 24.2 0.048 12.8 10.3 2.2 2 0 0 2 2 2 0 SprA-related family TERB2 PF15101.6 CDI78159.1 - 6 6.9 20.4 9.7 6.2 12.1 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4834 PF16118.5 CDI78159.1 - 6.5 7.8 12.3 2.6 9.0 4.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Band_3_cyto PF07565.13 CDI78159.1 - 8.6 6.1 10.5 0.25 11.1 2.4 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Exonuc_VII_L PF02601.15 CDI78159.1 - 8.9 5.8 16.6 8.1 5.9 7.3 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit RskA PF10099.9 CDI78159.1 - 9 6.5 28.2 9.4 6.5 6.0 3.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI78160.1 - 0.00093 19.5 9.0 0.00093 19.5 9.0 13.6 4 3 6 10 10 10 4 Anti-sigma-K factor rskA RskA PF10099.9 CDI78161.1 - 0.0007 19.9 7.8 0.0007 19.9 7.8 5.8 2 2 2 5 5 5 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI78161.1 - 0.015 14.9 2.7 0.015 14.9 2.7 3.4 2 1 0 3 3 3 0 Spt20 family Conotoxin PF02950.17 CDI78161.1 - 0.033 15.2 2.4 0.033 15.2 2.4 5.2 4 1 1 5 5 5 0 Conotoxin Med15 PF09606.10 CDI78161.1 - 0.033 12.9 31.7 0.3 9.7 19.1 2.5 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Arif-1 PF06770.11 CDI78161.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) TFIIA PF03153.13 CDI78161.1 - 0.17 11.8 47.5 0.15 12.0 8.0 2.6 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Peptidase_M41 PF01434.18 CDI78162.1 - 6.3e-37 127.3 2.1 8.7e-36 123.6 2.1 2.5 1 1 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CDI78162.1 - 8.7e-26 90.9 0.0 9.8e-25 87.5 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI78162.1 - 1.2e-05 25.0 0.2 3.6e-05 23.5 0.2 1.8 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CDI78162.1 - 0.015 15.1 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 CDI78162.1 - 0.068 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain NTP_transf_3 PF12804.7 CDI78162.1 - 0.36 11.2 0.1 0.36 11.2 0.1 4.8 5 1 0 5 5 5 0 MobA-like NTP transferase domain AP2 PF00847.20 CDI78163.1 - 7.5e-05 22.9 2.5 7.5e-05 22.9 2.5 2.2 2 0 0 2 2 2 1 AP2 domain zf-CCCH PF00642.24 CDI78164.1 - 1.2e-07 31.4 14.4 0.00015 21.5 3.0 3.6 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDI78164.1 - 0.00014 21.5 8.9 0.0076 16.0 3.1 2.8 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 CDI78164.1 - 0.00098 19.8 0.0 0.00098 19.8 0.0 5.6 5 1 0 5 5 5 2 Torus domain zf_CCCH_4 PF18345.1 CDI78164.1 - 0.0013 18.7 18.0 0.0036 17.3 1.6 3.6 4 1 0 4 4 4 2 Zinc finger domain zf-CCCH_3 PF15663.5 CDI78164.1 - 1.1 9.5 13.8 0.092 13.0 0.5 3.9 2 1 1 3 3 3 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 CDI78164.1 - 2.7 8.6 7.2 6 7.5 1.7 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Hist_deacetyl PF00850.19 CDI78165.1 - 2e-41 142.5 0.0 3.1e-40 138.6 0.0 2.7 2 1 1 3 3 3 1 Histone deacetylase domain Ank_2 PF12796.7 CDI78165.1 - 7.1e-10 39.3 1.8 2.1e-06 28.2 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI78165.1 - 8.4e-09 35.8 2.4 0.00032 21.2 0.3 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI78165.1 - 8.5e-09 35.5 1.0 7.2e-07 29.4 0.3 3.2 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI78165.1 - 1.3e-06 28.2 3.8 0.078 13.6 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CDI78165.1 - 0.00037 20.8 13.9 0.0015 18.9 0.8 4.3 4 0 0 4 4 4 2 Ankyrin repeat RAP PF08373.10 CDI78166.1 - 0.019 15.0 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 RAP domain DEAD PF00270.29 CDI78167.1 - 5.4e-21 75.1 1.3 6.6e-19 68.4 0.0 3.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI78167.1 - 1.5e-13 51.0 1.4 3.4e-13 49.9 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Androgen_recep PF02166.16 CDI78167.1 - 0.0036 16.2 10.6 0.0036 16.2 10.6 7.4 5 2 1 7 7 7 1 Androgen receptor AAA_22 PF13401.6 CDI78167.1 - 0.15 12.4 3.8 8.5 6.7 0.0 3.8 3 1 1 4 4 4 0 AAA domain RGS12_us1 PF16613.5 CDI78167.1 - 1.9 8.8 7.2 2.4 8.5 1.3 2.6 2 0 0 2 2 2 0 Unstructured region of RGS12 FAM60A PF15396.6 CDI78167.1 - 3.3 7.7 21.4 0.44 10.5 1.3 3.2 3 0 0 3 3 3 0 Protein Family FAM60A NAM-associated PF14303.6 CDI78168.1 - 0.0021 18.8 0.5 0.0021 18.8 0.5 9.0 6 3 2 8 8 8 1 No apical meristem-associated C-terminal domain UbiA PF01040.18 CDI78169.1 - 6.6e-08 32.2 0.4 6.6e-08 32.2 0.4 2.9 1 1 1 3 3 3 1 UbiA prenyltransferase family RAP1 PF07218.11 CDI78169.1 - 2 6.6 8.3 2.7 6.1 8.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ANAPC_CDC26 PF10471.9 CDI78170.1 - 0.00034 21.4 4.2 0.00034 21.4 4.2 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex APC subunit CDC26 Lin-8 PF03353.15 CDI78170.1 - 0.0033 17.0 8.0 0.0044 16.6 8.0 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI78170.1 - 0.011 15.7 10.6 0.013 15.4 10.6 1.0 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI78170.1 - 0.044 12.6 8.2 0.059 12.2 8.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PorA PF11271.8 CDI78170.1 - 0.096 12.0 2.4 0.13 11.5 2.4 1.1 1 0 0 1 1 1 0 Porin PorA Exonuc_VII_L PF02601.15 CDI78170.1 - 0.32 10.5 8.5 0.42 10.1 8.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Folliculin PF11704.8 CDI78170.1 - 0.36 10.7 7.2 0.089 12.7 3.8 1.7 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport RAP1 PF07218.11 CDI78170.1 - 4.5 5.4 6.2 4.7 5.4 6.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) EI24 PF07264.11 CDI78171.1 - 8.3e-07 29.4 0.3 0.018 15.3 0.0 2.4 2 0 0 2 2 2 2 Etoposide-induced protein 2.4 (EI24) DUF2367 PF10164.9 CDI78171.1 - 0.05 14.1 0.2 0.05 14.1 0.2 7.5 5 2 1 7 7 7 0 Uncharacterized conserved protein (DUF2367) Plasmodium_Vir PF05795.11 CDI78171.1 - 0.13 11.6 0.0 0.13 11.6 0.0 4.0 3 2 0 3 3 3 0 Plasmodium vivax Vir protein Herpes_pp85 PF04637.12 CDI78171.1 - 1.7 7.0 5.0 2.8 6.3 5.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Slu7 PF11708.8 CDI78173.1 - 6.9e-92 308.0 54.1 5.3e-90 301.8 44.5 3.6 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor Dicty_REP PF05086.12 CDI78173.1 - 6.2 4.7 8.3 10 4.0 8.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SIR2 PF02146.17 CDI78174.1 - 1.8e-28 99.7 0.0 2.5e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CDI78174.1 - 0.00052 19.8 0.0 0.00078 19.2 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain GMC_oxred_N PF00732.19 CDI78176.1 - 5.2e-18 65.4 0.1 1.8e-08 34.1 0.0 2.6 3 0 0 3 3 3 2 GMC oxidoreductase GMC_oxred_C PF05199.13 CDI78176.1 - 1.3e-08 35.5 0.0 0.00068 20.2 0.0 2.6 2 0 0 2 2 2 2 GMC oxidoreductase GIDA PF01134.22 CDI78176.1 - 0.00013 21.1 1.5 0.00024 20.3 1.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDI78176.1 - 0.00014 21.1 1.6 0.00025 20.2 1.6 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CDI78176.1 - 0.0002 21.5 0.9 0.00052 20.2 0.9 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CDI78176.1 - 0.00031 19.6 0.3 0.00047 19.0 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CDI78176.1 - 0.0012 18.2 1.1 0.0027 17.0 1.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDI78176.1 - 0.0018 17.7 0.9 0.0033 16.8 0.9 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDI78176.1 - 0.0019 17.5 0.1 0.0035 16.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDI78176.1 - 0.0024 17.5 0.3 0.0024 17.5 0.3 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDI78176.1 - 0.007 16.9 0.3 0.022 15.3 0.1 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI78176.1 - 0.021 14.1 0.4 0.18 11.0 0.5 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 CDI78176.1 - 0.031 12.8 0.0 0.053 12.0 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor Thi4 PF01946.17 CDI78176.1 - 0.043 13.1 0.2 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 CDI78176.1 - 0.053 12.6 0.4 0.11 11.5 0.4 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Utp11 PF03998.13 CDI78177.1 - 5.1 6.9 29.4 2.7 7.8 20.4 2.3 2 0 0 2 2 2 0 Utp11 protein Ribosomal_L22 PF00237.19 CDI78178.1 - 2.4e-20 72.7 0.1 3.2e-20 72.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e ELFV_dehydrog_N PF02812.18 CDI78179.1 - 8.6e-41 138.9 0.0 1.6e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 CDI78179.1 - 1.5e-25 90.3 0.2 2.1e-25 89.9 0.2 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.6 CDI78179.1 - 0.0028 18.0 0.1 0.0046 17.4 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding ThiF PF00899.21 CDI78179.1 - 0.042 13.2 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 ThiF family AdoHcyase_NAD PF00670.21 CDI78179.1 - 0.11 12.5 0.2 0.22 11.6 0.2 1.4 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain PGK PF00162.19 CDI78180.1 - 3.4e-122 408.0 0.1 8.4e-122 406.8 0.0 1.7 2 1 0 2 2 2 1 Phosphoglycerate kinase SR-25 PF10500.9 CDI78180.1 - 0.001 18.7 4.1 0.0023 17.6 4.1 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI78180.1 - 0.0027 17.8 12.5 0.0027 17.8 12.5 1.5 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit zf-CCHC_3 PF13917.6 CDI78181.1 - 1.1e-16 60.5 4.1 1.1e-16 60.5 4.1 2.1 2 0 0 2 2 2 1 Zinc knuckle SR-25 PF10500.9 CDI78181.1 - 0.00088 19.0 45.0 0.00088 19.0 45.0 7.0 2 1 4 7 7 7 2 Nuclear RNA-splicing-associated protein Tuberin PF03542.16 CDI78181.1 - 0.34 10.0 0.0 0.34 10.0 0.0 2.6 3 0 0 3 3 3 0 Tuberin Bestrophin PF01062.21 CDI78181.1 - 4.5 6.6 6.1 2.3 7.5 0.0 3.1 3 1 1 4 4 4 0 Bestrophin, RFP-TM, chloride channel Chorein_N PF12624.7 CDI78182.1 - 8.3e-07 29.1 0.2 8.3e-07 29.1 0.2 15.1 21 0 0 21 21 21 1 N-terminal region of Chorein or VPS13 WD40 PF00400.32 CDI78183.1 - 3.8e-23 81.3 36.0 0.00016 22.4 0.1 11.7 11 2 0 11 11 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78183.1 - 3.9e-08 33.5 0.3 14 6.0 0.0 7.4 5 1 2 8 8 7 0 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CDI78183.1 - 0.00074 19.8 0.1 0.0024 18.1 0.1 1.9 1 0 0 1 1 1 1 Dip2/Utp12 Family RskA PF10099.9 CDI78183.1 - 0.012 15.9 91.1 0.15 12.3 2.4 7.8 5 2 1 6 6 6 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI78183.1 - 0.027 13.4 0.2 0.027 13.4 0.2 5.6 5 1 1 6 6 5 0 Protein of unknown function (DUF2722) WD40_like PF17005.5 CDI78183.1 - 0.051 12.9 0.0 0.44 9.8 0.0 2.4 3 0 0 3 3 3 0 WD40-like domain Otopetrin PF03189.13 CDI78183.1 - 0.057 12.2 0.0 1 8.1 0.0 2.6 1 1 0 1 1 1 0 Otopetrin TFIIA PF03153.13 CDI78183.1 - 0.4 10.6 59.9 0.021 14.8 17.9 4.7 4 1 0 4 4 4 0 Transcription factor IIA, alpha/beta subunit SpoIIIAH PF12685.7 CDI78183.1 - 1.5 8.6 33.6 0.089 12.6 4.0 4.3 4 0 0 4 4 4 0 SpoIIIAH-like protein Connexin PF00029.19 CDI78183.1 - 2.8 7.6 17.3 11 5.7 0.0 3.5 3 0 0 3 3 3 0 Connexin EOS1 PF12326.8 CDI78183.1 - 3.4 7.6 7.4 10 6.0 1.0 3.4 3 0 0 3 3 3 0 N-glycosylation protein Serinc PF03348.15 CDI78183.1 - 4 6.3 7.7 0.61 9.0 0.2 2.9 3 0 0 3 3 3 0 Serine incorporator (Serinc) Zip PF02535.22 CDI78183.1 - 6.7 5.8 8.8 43 3.2 4.3 3.1 3 0 0 3 3 3 0 ZIP Zinc transporter Androgen_recep PF02166.16 CDI78184.1 - 0.0055 15.6 5.3 0.0055 15.6 5.3 3.7 2 1 2 4 4 4 1 Androgen receptor RTC PF01137.21 CDI78184.1 - 0.0059 15.8 0.1 0.0065 15.7 0.1 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 CDI78184.1 - 0.0069 16.9 7.3 0.085 13.4 7.3 2.7 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DUF4834 PF16118.5 CDI78184.1 - 0.015 16.2 1.0 0.015 16.2 1.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) FAM60A PF15396.6 CDI78184.1 - 0.1 12.6 0.4 0.49 10.4 0.4 2.0 1 1 0 1 1 1 0 Protein Family FAM60A Spt20 PF12090.8 CDI78184.1 - 0.24 11.0 18.7 0.4 10.3 11.8 2.2 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI78184.1 - 1.6 8.6 25.8 3.1 7.7 25.8 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4820 PF16091.5 CDI78184.1 - 4.5 6.6 7.4 0.88 8.9 0.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) Thioredoxin_8 PF13905.6 CDI78185.1 - 2e-13 50.5 0.0 3.2e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like PI3_PI4_kinase PF00454.27 CDI78186.1 - 5.6e-39 134.5 0.2 1.2e-38 133.4 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CDI78186.1 - 1.8e-09 37.3 0.1 2.3e-07 30.4 0.0 2.9 3 0 0 3 3 3 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) SPX PF03105.19 CDI78186.1 - 5.6e-05 23.2 15.3 5.6e-05 23.2 15.3 7.1 4 2 1 5 5 5 2 SPX domain Apt1 PF10351.9 CDI78186.1 - 0.00047 19.2 12.4 0.00047 19.2 12.4 5.7 4 2 0 4 4 4 1 Golgi-body localisation protein domain PI3K_C2 PF00792.24 CDI78186.1 - 0.0089 15.9 0.0 0.0089 15.9 0.0 3.5 4 0 0 4 4 4 1 Phosphoinositide 3-kinase C2 Lactamase_B_2 PF12706.7 CDI78187.1 - 6.5e-26 91.1 7.7 1.1e-19 70.7 0.1 3.1 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDI78187.1 - 1.9e-07 31.1 3.3 6.1e-06 26.2 0.0 2.9 3 0 0 3 3 3 2 Beta-lactamase superfamily domain TFIIA PF03153.13 CDI78187.1 - 0.0024 18.0 15.4 0.0024 18.0 15.4 4.7 3 2 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Lactamase_B PF00753.27 CDI78187.1 - 0.0045 17.0 0.2 0.013 15.6 0.2 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF913 PF06025.12 CDI78188.1 - 0.22 10.5 13.7 0.3 10.0 13.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Smg8_Smg9 PF10220.9 CDI78188.1 - 0.4 8.9 24.8 0.45 8.8 24.8 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Presenilin PF01080.17 CDI78188.1 - 2.6 6.7 32.5 2.8 6.6 32.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 CDI78188.1 - 2.6 7.6 22.1 2.7 7.5 22.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) MDFI PF15316.6 CDI78188.1 - 3.2 7.8 17.7 3.6 7.6 17.7 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Endostatin PF06482.11 CDI78188.1 - 8.8 5.7 25.3 12 5.2 25.3 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CNDH2_C PF16858.5 CDI78188.1 - 9.6 6.0 28.9 12 5.7 28.9 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SPX PF03105.19 CDI78189.1 - 5.6 6.8 9.5 6.9 6.5 9.5 1.1 1 0 0 1 1 1 0 SPX domain DUF908 PF06012.12 CDI78190.1 - 0.00015 21.3 2.4 0.00018 21.0 2.4 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) SPX PF03105.19 CDI78190.1 - 0.00028 20.9 10.8 0.0003 20.8 10.8 1.2 1 0 0 1 1 1 1 SPX domain EFG_IV PF03764.18 CDI78190.1 - 0.064 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G, domain IV Sec3_C PF09763.9 CDI78190.1 - 0.38 9.1 7.7 0.44 8.9 7.7 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 SpoIIIAH PF12685.7 CDI78190.1 - 1.6 8.5 8.8 2 8.2 8.8 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein NPR3 PF03666.13 CDI78190.1 - 2.7 6.7 10.3 4.1 6.1 10.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 CDI78190.1 - 5.6 5.7 28.2 18 4.0 27.7 1.8 2 0 0 2 2 2 0 Golgi-body localisation protein domain SSP160 PF06933.11 CDI78190.1 - 8.7 4.4 40.7 11 4.1 40.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RskA PF10099.9 CDI78192.1 - 4.7e-05 23.8 1.2 4.7e-05 23.8 1.2 40.8 9 8 19 28 28 28 1 Anti-sigma-K factor rskA DUF3474 PF11960.8 CDI78193.1 - 7.4 6.8 7.3 2.2 8.5 2.1 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF3474) DFRP_C PF16543.5 CDI78193.1 - 8.1 7.0 9.3 15 6.2 6.5 2.5 2 1 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 SURF6 PF04935.12 CDI78194.1 - 5.5 6.7 24.5 0.11 12.3 3.2 3.4 3 0 0 3 3 3 0 Surfeit locus protein 6 RPN2_C PF18004.1 CDI78195.1 - 1.4 8.8 25.8 2.4 8.1 25.8 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CobT PF06213.12 CDI78195.1 - 2.1 7.6 38.1 2.8 7.3 38.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 CDI78195.1 - 3.2 7.0 19.0 4 6.7 19.0 1.1 1 0 0 1 1 1 0 NOA36 protein Paf1 PF03985.13 CDI78195.1 - 3.4 6.6 37.6 3.8 6.4 37.6 1.0 1 0 0 1 1 1 0 Paf1 Pox_Ag35 PF03286.14 CDI78195.1 - 4.9 6.9 23.6 5.8 6.6 23.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF5523 PF17661.1 CDI78195.1 - 5.4 6.6 30.2 7.6 6.1 30.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SpoIIP PF07454.11 CDI78195.1 - 6.2 6.2 28.0 8.7 5.7 28.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pal1 PF08316.11 CDI78195.1 - 9.6 7.0 13.0 13 6.6 13.0 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein Pkinase PF00069.25 CDI78198.1 - 4.5e-08 32.8 0.1 8.6e-08 31.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 CDI78198.1 - 6.4e-05 22.4 0.7 0.00012 21.5 0.7 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 CDI78198.1 - 0.0087 15.4 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-bind_6 PF13921.6 CDI78199.1 - 1.3e-05 25.3 1.2 2.3e-05 24.6 1.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CDI78199.1 - 0.00016 21.8 0.4 0.00027 21.1 0.4 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CDI78199.1 - 0.00019 21.6 1.1 0.00033 20.8 1.1 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.8 CDI78199.1 - 0.11 12.6 0.2 0.15 12.2 0.2 1.2 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain CCDC24 PF15669.5 CDI78200.1 - 0.023 14.6 0.3 0.049 13.5 0.3 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family HHH_4 PF14490.6 CDI78200.1 - 0.21 11.6 0.0 0.52 10.3 0.0 1.6 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain Ribosomal_L22 PF00237.19 CDI78201.1 - 3.9e-05 23.8 0.0 0.00019 21.6 0.0 2.2 2 1 0 2 2 2 1 Ribosomal protein L22p/L17e K_channel_TID PF07941.11 CDI78201.1 - 0.12 12.8 2.3 0.25 11.8 2.3 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF5421 PF17458.2 CDI78201.1 - 0.17 11.2 1.3 0.25 10.7 1.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5421) TFIIF_beta PF02270.15 CDI78202.1 - 0.0012 18.9 0.1 0.0027 17.8 0.1 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain THOC7 PF05615.13 CDI78202.1 - 0.0017 18.7 0.3 0.0019 18.4 0.3 1.1 1 0 0 1 1 1 1 Tho complex subunit 7 RPA_C PF08784.11 CDI78202.1 - 0.021 15.5 0.1 0.058 14.1 0.0 1.8 2 0 0 2 2 2 0 Replication protein A C terminal TIMELESS PF04821.14 CDI78203.1 - 0.063 12.5 0.1 0.077 12.3 0.1 1.1 1 0 0 1 1 1 0 Timeless protein BRI3BP PF14965.6 CDI78203.1 - 0.15 11.5 0.9 0.25 10.8 0.9 1.3 1 0 0 1 1 1 0 Negative regulator of p53/TP53 AAA_16 PF13191.6 CDI78205.1 - 3.2e-07 30.9 0.3 1.9e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CDI78205.1 - 0.018 15.5 0.0 0.076 13.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CDI78205.1 - 0.033 14.1 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CDI78205.1 - 0.06 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 CDI78205.1 - 0.11 12.4 0.0 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 CDI78205.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 CDI78205.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 CDI78206.1 - 2.5e-25 89.2 0.0 4e-24 85.3 0.0 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDI78206.1 - 2e-06 27.9 3.0 8.4e-06 25.9 0.0 2.3 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 CDI78206.1 - 0.01 15.2 0.8 0.025 13.9 0.8 1.5 1 1 0 1 1 1 0 SecA DEAD-like domain DDHD PF02862.17 CDI78206.1 - 0.022 14.9 8.1 0.043 14.0 8.1 1.5 1 0 0 1 1 1 0 DDHD domain GREB1 PF15782.5 CDI78206.1 - 0.19 8.8 15.3 0.26 8.4 15.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer EPL1 PF10513.9 CDI78206.1 - 0.2 12.1 13.9 0.37 11.2 13.9 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like CCSAP PF15748.5 CDI78206.1 - 0.45 10.6 26.5 0.66 10.1 26.5 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF2052 PF09747.9 CDI78206.1 - 0.52 10.4 22.3 0.88 9.7 22.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TFIIA PF03153.13 CDI78206.1 - 1.1 9.2 35.9 2.1 8.3 35.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI78206.1 - 1.2 8.6 20.1 1.6 8.2 20.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Band_3_cyto PF07565.13 CDI78206.1 - 1.2 8.8 9.9 1.9 8.2 9.9 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RR_TM4-6 PF06459.12 CDI78206.1 - 1.4 8.7 25.3 2.2 8.0 25.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI78206.1 - 1.6 6.9 25.5 2 6.6 25.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4746 PF15928.5 CDI78206.1 - 1.6 8.1 12.5 2.6 7.4 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SOBP PF15279.6 CDI78206.1 - 2.3 8.8 14.3 3.4 8.2 14.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DDRGK PF09756.9 CDI78206.1 - 2.4 7.7 23.5 3.8 7.1 23.5 1.2 1 0 0 1 1 1 0 DDRGK domain Hid1 PF12722.7 CDI78206.1 - 3.3 5.7 17.9 4.3 5.3 17.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI78206.1 - 3.6 6.3 24.7 5.8 5.6 24.7 1.3 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI78206.1 - 4.8 7.1 15.3 7.6 6.5 15.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Sec62 PF03839.16 CDI78206.1 - 5.7 6.4 12.3 9 5.7 12.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 CDI78206.1 - 6.1 5.6 11.4 8 5.2 11.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI78206.1 - 6.1 5.0 20.6 8.6 4.5 20.6 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI78206.1 - 7.3 5.5 16.9 9.9 5.1 16.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 CDI78206.1 - 7.9 5.3 15.6 12 4.7 15.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) XRN_M PF17846.1 CDI78206.1 - 9 5.1 12.4 15 4.4 12.4 1.3 1 0 0 1 1 1 0 Xrn1 helical domain NPR3 PF03666.13 CDI78206.1 - 9.2 4.9 18.5 13 4.5 18.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CNDH2_C PF16858.5 CDI78207.1 - 0.0032 17.4 12.0 0.0032 17.4 12.0 4.6 4 0 0 4 4 4 3 Condensin II complex subunit CAP-H2 or CNDH2, C-term PepSY_TM PF03929.16 CDI78207.1 - 0.02 14.6 1.0 0.02 14.6 1.0 7.5 2 1 0 2 2 2 0 PepSY-associated TM region WD40 PF00400.32 CDI78208.1 - 6.8e-58 191.3 11.3 1.6e-09 38.2 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78208.1 - 3.9e-22 78.3 0.0 0.00042 20.6 0.0 5.4 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDI78208.1 - 2.4e-05 23.5 0.0 0.92 8.4 0.0 4.1 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 CDI78208.1 - 7.5e-05 23.2 0.0 0.00013 22.4 0.0 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 CDI78208.1 - 0.00011 22.1 0.0 0.16 11.8 0.0 2.5 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 CDI78208.1 - 0.0093 14.9 2.8 8.1 5.3 0.0 3.8 3 1 1 4 4 4 2 Partner and localizer of BRCA2 WD40 domain T4BSS_DotI_IcmL PF11393.8 CDI78208.1 - 0.01 15.3 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component Nup160 PF11715.8 CDI78208.1 - 0.048 12.3 8.9 0.18 10.4 0.0 4.3 4 1 0 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.5 CDI78208.1 - 0.14 11.4 0.0 40 3.4 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain SR-25 PF10500.9 CDI78208.1 - 0.59 9.7 32.6 0.63 9.6 8.7 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein EF-hand_4 PF12763.7 CDI78209.1 - 1.3e-11 44.4 0.0 9.8e-06 25.5 0.0 2.9 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 CDI78209.1 - 0.0036 16.8 0.0 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDI78209.1 - 0.0083 16.6 0.0 0.044 14.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI78209.1 - 0.091 12.7 0.0 0.33 11.0 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain CLAMP PF14769.6 CDI78210.1 - 7.3e-15 55.2 0.1 1.3e-14 54.5 0.1 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 Pro_isomerase PF00160.21 CDI78211.1 - 3.9e-28 98.7 0.0 1.8e-27 96.5 0.0 1.9 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med3 PF11593.8 CDI78211.1 - 0.00091 18.5 8.2 0.0012 18.1 8.2 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal RskA PF10099.9 CDI78211.1 - 1.3 9.3 18.2 0.27 11.5 1.8 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA BRO1 PF03097.18 CDI78213.1 - 1.3e-18 67.0 0.2 1.6e-16 60.2 2.6 4.2 4 1 0 4 4 4 2 BRO1-like domain PIN_9 PF18477.1 CDI78213.1 - 0.54 10.6 2.5 2.4 8.5 0.4 3.0 2 0 0 2 2 2 0 PIN like domain DUF572 PF04502.13 CDI78214.1 - 1 8.9 11.1 1.8 8.1 11.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Stm1_N PF09598.10 CDI78214.1 - 5.5 7.9 13.6 1.5 9.7 4.3 3.3 3 0 0 3 3 3 0 Stm1 NOG1_N PF17835.1 CDI78215.1 - 0.0036 17.3 0.0 0.019 14.9 0.0 1.9 2 0 0 2 2 2 1 NOG1 N-terminal helical domain DUF4778 PF16008.5 CDI78217.1 - 0.31 11.1 9.8 1 9.3 9.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) ALMT PF11744.8 CDI78217.1 - 2 7.1 6.5 4.9 5.9 6.5 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter ORC_WH_C PF18137.1 CDI78217.1 - 3.6 7.6 8.9 0.72 9.9 3.6 2.7 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal RR_TM4-6 PF06459.12 CDI78217.1 - 6.8 6.4 9.6 31 4.2 9.6 2.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 CDI78217.1 - 9.8 6.7 8.9 2.1 8.8 4.4 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Cwf_Cwc_15 PF04889.12 CDI78218.1 - 0.061 13.0 28.3 0.069 12.9 28.3 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Trypan_PARP PF05887.11 CDI78218.1 - 0.86 9.6 3.6 1 9.3 3.6 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ureide_permease PF07168.11 CDI78218.1 - 2.7 6.7 15.0 3.1 6.4 15.0 1.1 1 0 0 1 1 1 0 Ureide permease Pox_Ag35 PF03286.14 CDI78218.1 - 6.7 6.5 23.5 8.1 6.2 23.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SR-25 PF10500.9 CDI78219.1 - 0.005 16.5 19.0 0.005 16.5 19.0 3.5 4 1 1 5 5 5 1 Nuclear RNA-splicing-associated protein ORC3_N PF07034.11 CDI78219.1 - 0.18 10.9 6.5 2.5 7.1 0.1 2.7 3 0 0 3 3 3 0 Origin recognition complex (ORC) subunit 3 N-terminus PriA_C PF18074.1 CDI78219.1 - 0.23 12.3 0.0 0.23 12.3 0.0 3.5 4 1 1 5 5 5 0 Primosomal protein N C-terminal domain DUF4834 PF16118.5 CDI78219.1 - 3.7 8.6 10.4 5.2 8.1 0.5 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Ank_5 PF13857.6 CDI78220.1 - 0.00017 21.8 8.0 0.039 14.3 0.7 4.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) LRR_8 PF13855.6 CDI78220.1 - 0.00023 20.9 11.0 0.0003 20.5 7.0 2.7 2 1 0 2 2 2 1 Leucine rich repeat Velvet PF11754.8 CDI78220.1 - 0.00084 19.4 0.1 0.00084 19.4 0.1 12.9 5 4 2 9 9 9 1 Velvet factor Ank_2 PF12796.7 CDI78220.1 - 0.001 19.6 20.7 0.0024 18.4 0.1 6.4 7 0 0 7 7 7 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI78220.1 - 0.0029 18.1 17.2 0.0046 17.5 0.1 6.4 7 0 0 7 7 7 1 Ankyrin repeats (many copies) PIP5K PF01504.18 CDI78220.1 - 6.8 5.8 0.0 0.44 9.7 2.1 9.3 7 3 0 7 7 7 0 Phosphatidylinositol-4-phosphate 5-Kinase Menin PF05053.13 CDI78221.1 - 1.4 7.2 11.9 1.4 7.2 11.9 1.0 1 0 0 1 1 1 0 Menin Erv26 PF04148.13 CDI78224.1 - 0.0066 16.3 2.8 0.0066 16.3 2.8 2.8 2 1 0 2 2 2 1 Transmembrane adaptor Erv26 FAM176 PF14851.6 CDI78224.1 - 0.015 15.0 6.2 0.015 15.0 6.2 4.0 2 2 1 3 3 3 0 FAM176 family Ni_hydr_CYTB PF01292.20 CDI78224.1 - 0.16 11.6 0.5 7.6 6.1 0.1 2.5 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 TALPID3 PF15324.6 CDI78225.1 - 1.1 6.9 3.2 1.4 6.5 3.2 1.1 1 0 0 1 1 1 0 Hedgehog signalling target TFIIA PF03153.13 CDI78227.1 - 0.00062 19.9 15.5 0.00062 19.9 15.5 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit bMG10 PF17973.1 CDI78227.1 - 0.0044 17.2 0.9 0.01 16.1 0.9 1.5 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain AAA_lid_2 PF17863.1 CDI78227.1 - 0.042 13.7 0.3 0.11 12.4 0.3 1.7 1 0 0 1 1 1 0 AAA lid domain PepSY_TM PF03929.16 CDI78227.1 - 0.06 13.0 1.7 0.086 12.5 1.7 1.3 1 0 0 1 1 1 0 PepSY-associated TM region AAA_23 PF13476.6 CDI78227.1 - 0.074 13.6 16.2 0.2 12.1 5.4 2.1 2 0 0 2 2 2 0 AAA domain PIP5K PF01504.18 CDI78227.1 - 0.17 11.1 5.4 0.24 10.6 5.1 1.5 1 1 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase RNA_pol_Rpb1_5 PF04998.17 CDI78227.1 - 0.22 10.9 3.4 0.4 10.1 3.4 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 MCU PF04678.13 CDI78227.1 - 0.28 11.2 11.4 0.16 12.1 2.4 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter RskA PF10099.9 CDI78227.1 - 0.56 10.5 8.2 0.025 14.9 2.4 1.8 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI78227.1 - 1 8.2 31.3 0.013 14.5 15.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI78227.1 - 2.2 8.6 11.1 0.22 11.9 2.8 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like GBP_C PF02841.14 CDI78227.1 - 2.2 7.6 22.1 0.14 11.6 7.5 2.2 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Orf78 PF06024.12 CDI78227.1 - 2.3 8.6 4.4 0.89 9.9 0.5 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Spore_III_AF PF09581.10 CDI78227.1 - 2.7 8.0 11.3 0.19 11.7 3.9 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) SprA-related PF12118.8 CDI78227.1 - 4.3 6.4 27.3 0.011 14.9 13.0 2.1 2 0 0 2 2 2 0 SprA-related family CTU2 PF10288.9 CDI78227.1 - 5.7 7.2 12.9 7.5 6.8 8.3 2.5 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Med15 PF09606.10 CDI78227.1 - 5.8 5.5 29.7 0.019 13.7 15.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal ALMT PF11744.8 CDI78227.1 - 7.4 5.3 12.2 0.24 10.2 4.3 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter G0-G1_switch_2 PF15103.6 CDI78227.1 - 8.4 6.9 10.5 2.2 8.7 3.9 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 SRP14 PF02290.15 CDI78228.1 - 4.7e-17 62.1 0.0 4.7e-17 62.1 0.0 2.2 1 1 1 2 2 1 1 Signal recognition particle 14kD protein EOS1 PF12326.8 CDI78228.1 - 0.85 9.5 3.2 0.78 9.7 3.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein Peptidase_S49_N PF08496.10 CDI78228.1 - 0.97 9.5 10.0 1.4 9.0 10.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EIIBC-GUT_N PF03612.14 CDI78228.1 - 1.2 8.9 7.6 1.4 8.6 7.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Spt20 PF12090.8 CDI78228.1 - 1.3 8.5 18.8 1.7 8.2 18.8 1.1 1 0 0 1 1 1 0 Spt20 family Neur_chan_memb PF02932.16 CDI78228.1 - 1.5 8.8 5.0 1.5 8.8 5.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI78228.1 - 2.6 6.7 9.7 2.6 6.7 9.7 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI78228.1 - 2.7 6.6 6.5 2.7 6.6 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Connexin PF00029.19 CDI78228.1 - 3 7.5 6.1 3.3 7.4 6.1 1.3 1 0 0 1 1 1 0 Connexin PBP_sp32 PF07222.12 CDI78228.1 - 3.6 7.0 12.7 4.6 6.6 12.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TMEM214 PF10151.9 CDI78228.1 - 4.4 5.7 12.2 5.2 5.4 12.2 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator UCH PF00443.29 CDI78229.1 - 6.8e-39 133.9 0.0 3.9e-38 131.4 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CDI78229.1 - 5.6e-12 45.8 0.0 7.7e-11 42.2 0.0 2.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 CDI78229.1 - 1.3e-10 40.9 10.3 1.4e-05 24.9 0.0 3.4 3 0 0 3 3 3 2 UBA/TS-N domain UCH_1 PF13423.6 CDI78229.1 - 7.2e-05 22.5 4.0 0.039 13.5 0.0 3.3 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Dis3l2_C_term PF17877.1 CDI78229.1 - 0.084 13.2 0.1 0.2 12.0 0.1 1.6 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal Peptidase_A17 PF05380.13 CDI78230.1 - 0.29 11.1 7.0 0.86 9.6 2.2 2.5 1 1 1 2 2 2 0 Pao retrotransposon peptidase Exonuc_VII_L PF02601.15 CDI78230.1 - 0.72 9.4 6.7 0.93 9.0 6.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MeaB PF03308.16 CDI78230.1 - 0.81 8.6 5.0 1.1 8.1 5.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2362 PF10154.9 CDI78230.1 - 0.91 8.4 11.9 1.2 8.0 11.9 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Retrotrans_gag PF03732.17 CDI78230.1 - 1.1 9.6 11.5 1.7 8.9 9.3 2.3 2 1 1 3 3 3 0 Retrotransposon gag protein AAA_6 PF12774.7 CDI78231.1 - 5.3e-98 328.0 0.0 4.8e-64 216.4 0.0 3.6 2 1 1 3 3 3 3 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI78231.1 - 4.7e-73 246.6 5.8 3.4e-48 164.7 0.0 3.4 3 0 0 3 3 3 2 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 CDI78231.1 - 8.8e-36 123.1 0.0 4.6e-32 111.0 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_lid_1 PF17857.1 CDI78231.1 - 5.8e-16 58.5 0.1 1.8e-15 57.0 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 CDI78231.1 - 5.9e-13 49.0 0.0 1.9e-12 47.4 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 CDI78231.1 - 5.1e-12 46.0 0.0 4.6e-07 29.9 0.0 4.8 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI78231.1 - 2.7e-06 27.9 0.0 0.081 13.3 0.0 4.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 CDI78231.1 - 4.1e-06 27.4 0.1 0.016 15.7 0.0 4.2 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 CDI78231.1 - 2.4e-05 24.7 0.2 1.3 9.4 0.0 4.3 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 CDI78231.1 - 0.00023 21.0 0.1 0.36 10.5 0.1 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 CDI78231.1 - 0.0014 18.4 0.3 0.071 12.9 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 CDI78231.1 - 0.0014 18.9 0.2 0.61 10.3 0.0 4.3 4 0 0 4 4 4 1 AAA domain AAA_33 PF13671.6 CDI78231.1 - 0.0043 17.2 0.1 0.41 10.8 0.0 3.1 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.23 CDI78231.1 - 0.0043 17.1 0.0 0.029 14.5 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CDI78231.1 - 0.0084 16.4 0.3 1.4 9.2 0.0 3.8 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 CDI78231.1 - 0.013 15.4 1.8 3.3 7.6 0.0 3.8 3 1 0 3 3 2 0 NACHT domain Mg_chelatase PF01078.21 CDI78231.1 - 0.02 14.3 2.0 0.17 11.2 0.1 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CDI78231.1 - 0.022 14.3 0.3 0.36 10.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 CDI78231.1 - 0.025 14.5 0.1 0.17 11.8 0.0 2.4 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 AAA_30 PF13604.6 CDI78231.1 - 0.03 14.0 2.1 0.72 9.5 0.1 3.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CDI78231.1 - 0.034 14.5 0.3 4.2 7.7 0.0 3.7 3 0 0 3 3 2 0 AAA domain ABC_tran PF00005.27 CDI78231.1 - 0.035 14.6 0.2 0.26 11.8 0.0 2.6 3 0 0 3 3 1 0 ABC transporter Dynamin_M PF01031.20 CDI78231.1 - 0.044 13.0 1.9 0.11 11.7 1.2 2.0 2 0 0 2 2 2 0 Dynamin central region PTS_IIA PF02255.16 CDI78231.1 - 0.045 13.8 0.6 0.15 12.1 0.6 1.9 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit DegS PF05384.11 CDI78231.1 - 0.051 13.1 4.2 0.19 11.2 4.2 2.0 1 0 0 1 1 1 0 Sensor protein DegS Zeta_toxin PF06414.12 CDI78231.1 - 0.091 12.0 0.3 0.68 9.2 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.9 CDI78231.1 - 0.096 11.9 0.1 2 7.5 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 CDI78231.1 - 0.12 12.8 0.1 4.2 7.8 0.0 3.1 3 0 0 3 3 2 0 RNA helicase TsaE PF02367.17 CDI78231.1 - 0.15 12.1 0.3 3.5 7.7 0.0 3.2 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE UPF0149 PF03695.13 CDI78231.1 - 0.37 11.0 6.6 0.31 11.3 0.3 3.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) DUF948 PF06103.11 CDI78231.1 - 0.79 10.0 2.9 2.9 8.2 1.2 3.0 2 0 0 2 2 1 0 Bacterial protein of unknown function (DUF948) DegQ PF08181.11 CDI78231.1 - 1.9 8.6 4.9 0.67 10.1 0.2 2.7 3 0 0 3 3 2 0 DegQ (SacQ) family AAA_9 PF12781.7 CDI78232.1 - 7.7e-55 185.4 2.7 2.1e-52 177.4 0.0 2.8 3 0 0 3 3 3 2 ATP-binding dynein motor region Dynein_C PF18199.1 CDI78232.1 - 1.7e-50 172.0 0.5 2.6e-48 164.8 0.1 2.4 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 CDI78232.1 - 7.5e-39 132.5 0.2 1.2e-37 128.7 0.0 2.7 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 CDI78232.1 - 3.3e-38 131.6 4.8 3.3e-38 131.6 4.8 1.7 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 CDI78232.1 - 1.9e-37 128.6 0.0 3.8e-37 127.6 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain HrpB7 PF09486.10 CDI78232.1 - 0.00014 22.2 3.1 0.00014 22.2 3.1 3.0 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB7) DHR10 PF18595.1 CDI78232.1 - 0.00027 21.0 6.0 0.00027 21.0 6.0 2.8 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain CorA PF01544.18 CDI78232.1 - 0.017 14.4 0.5 0.017 14.4 0.5 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Fez1 PF06818.15 CDI78232.1 - 0.028 14.9 2.2 0.12 12.8 2.2 2.0 1 0 0 1 1 1 0 Fez1 UPF0242 PF06785.11 CDI78232.1 - 0.053 13.6 1.8 0.095 12.8 0.8 1.9 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus Sugarporin_N PF11471.8 CDI78232.1 - 0.14 12.1 2.3 1.1 9.2 0.3 3.1 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension Sec8_exocyst PF04048.14 CDI78232.1 - 0.23 11.3 6.1 0.2 11.5 0.2 3.2 3 1 1 4 4 3 0 Sec8 exocyst complex component specific domain BST2 PF16716.5 CDI78232.1 - 0.44 11.2 7.1 1.8 9.2 7.1 2.1 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 FadA PF09403.10 CDI78232.1 - 0.66 10.5 10.8 6.8 7.2 2.6 3.3 2 1 0 2 2 2 0 Adhesion protein FadA ATG16 PF08614.11 CDI78232.1 - 1.5 9.0 12.2 0.014 15.6 3.4 2.0 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) DUF745 PF05335.13 CDI78232.1 - 1.6 8.4 12.4 0.11 12.2 3.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Spc7 PF08317.11 CDI78232.1 - 3.2 6.5 14.7 0.031 13.1 4.6 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein PMEI PF04043.15 CDI78232.1 - 6.7 7.0 6.5 29 5.0 0.6 2.6 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor DegT_DnrJ_EryC1 PF01041.17 CDI78233.1 - 3e-16 59.7 0.0 1.8e-14 53.8 0.0 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3054 PF11255.8 CDI78233.1 - 0.31 11.6 1.3 0.97 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) WW PF00397.26 CDI78234.1 - 1.3e-07 31.5 1.0 3.1e-07 30.3 1.0 1.6 1 0 0 1 1 1 1 WW domain Glyco_hyd_101C PF17451.2 CDI78234.1 - 0.00098 19.4 0.9 0.0039 17.5 0.9 2.0 1 0 0 1 1 1 1 Glycosyl hydrolase 101 beta sandwich domain ABC_tran PF00005.27 CDI78235.1 - 6.2e-22 78.6 0.0 1e-21 77.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CDI78235.1 - 1.8e-10 40.6 3.3 2e-05 24.1 0.7 2.5 2 0 0 2 2 2 2 ABC-2 type transporter RsgA_GTPase PF03193.16 CDI78235.1 - 0.00019 21.4 0.1 0.00034 20.6 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDI78235.1 - 0.0065 16.2 0.1 0.016 15.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDI78235.1 - 0.01 15.9 0.1 0.018 15.1 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 CDI78235.1 - 0.026 14.1 1.0 0.049 13.2 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDI78235.1 - 0.033 14.6 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 CDI78235.1 - 0.095 13.2 0.0 0.15 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 CDI78235.1 - 0.21 11.6 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 Dynamin family IstB_IS21 PF01695.17 CDI78235.1 - 0.28 10.9 0.7 13 5.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Macscav_rec PF03523.13 CDI78236.1 - 0.082 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Macrophage scavenger receptor SURF1 PF02104.15 CDI78237.1 - 2.6e-27 96.2 0.0 2.9e-17 63.5 0.0 2.7 2 1 0 2 2 2 2 SURF1 family EFTUD2 PF16004.5 CDI78237.1 - 0.025 15.1 4.4 0.87 10.2 0.0 3.2 3 0 0 3 3 3 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus TB2_DP1_HVA22 PF03134.19 CDI78238.1 - 4.3e-14 52.2 3.4 6.5e-14 51.6 3.4 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Cpn60_TCP1 PF00118.24 CDI78239.1 - 3.3e-129 431.7 8.0 2.5e-128 428.8 8.0 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family RhodobacterPufX PF11511.8 CDI78239.1 - 0.02 14.5 2.1 0.067 12.8 1.8 2.0 2 0 0 2 2 2 0 Intrinsic membrane protein PufX B12-binding PF02310.19 CDI78239.1 - 0.094 12.8 0.2 0.36 10.9 0.2 2.0 2 0 0 2 2 2 0 B12 binding domain EOS1 PF12326.8 CDI78240.1 - 0.039 13.9 3.7 3.7 7.5 0.2 2.8 3 0 0 3 3 3 0 N-glycosylation protein Neurokinin_B PF03823.14 CDI78240.1 - 0.36 10.9 0.1 0.36 10.9 0.1 3.0 2 0 0 2 2 2 0 Neurokinin B SID-1_RNA_chan PF13965.6 CDI78240.1 - 0.43 8.9 3.0 2.6 6.3 0.2 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI78240.1 - 3.4 6.5 7.4 9.3 5.1 0.2 2.4 2 0 0 2 2 2 0 Serine incorporator (Serinc) BORG_CEP PF14957.6 CDI78240.1 - 3.8 8.7 14.9 0.53 11.4 1.6 3.1 3 0 0 3 3 3 0 Cdc42 effector DUF2464 PF10240.9 CDI78240.1 - 4.2 6.8 8.0 4.8 6.7 0.9 2.4 2 0 0 2 2 2 0 Multivesicular body subunit 12 CLN3 PF02487.17 CDI78240.1 - 5.3 6.0 16.1 0.36 9.8 2.9 2.5 2 0 0 2 2 2 0 CLN3 protein ATP-synt_I PF03899.15 CDI78240.1 - 6.8 7.1 6.5 0.95 9.9 1.6 2.1 2 0 0 2 2 2 0 ATP synthase I chain Metallophos PF00149.28 CDI78241.1 - 2e-10 41.6 0.2 3.9e-10 40.6 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPR_2 PF13041.6 CDI78242.1 - 4.1e-51 171.0 1.6 6.5e-11 42.3 0.0 8.8 5 3 4 9 9 9 8 PPR repeat family PPR_3 PF13812.6 CDI78242.1 - 4.8e-26 90.6 1.4 3.9e-07 30.1 0.0 7.2 6 1 2 8 8 8 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 CDI78242.1 - 1.9e-25 88.2 5.1 7.1e-05 22.4 0.0 9.4 10 0 0 10 10 10 6 PPR repeat PPR PF01535.20 CDI78242.1 - 6.4e-24 82.5 16.3 4.8e-05 23.3 0.0 10.2 11 0 0 11 11 11 6 PPR repeat PPR_long PF17177.4 CDI78242.1 - 3.9e-10 39.5 16.3 0.0014 18.0 0.2 6.4 3 2 3 6 6 6 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 CDI78242.1 - 0.0003 20.6 0.0 0.3 11.0 0.0 4.0 4 1 1 5 5 5 1 Mitochondrial ATPase expression HCNGP PF07818.13 CDI78243.1 - 4.1e-13 49.8 0.0 1e-12 48.5 0.0 1.7 1 0 0 1 1 1 1 HCNGP-like protein Peptidase_C1 PF00112.23 CDI78244.1 - 3.8e-32 112.2 6.6 1.8e-29 103.4 1.2 4.7 1 1 2 3 3 3 2 Papain family cysteine protease CathepsinC_exc PF08773.11 CDI78244.1 - 2.5e-06 27.8 0.2 2.5e-06 27.8 0.2 3.1 2 2 0 2 2 2 1 Cathepsin C exclusion domain Propeptide_C1 PF08127.13 CDI78244.1 - 0.042 13.7 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Peptidase family C1 propeptide V_ATPase_I PF01496.19 CDI78244.1 - 0.49 8.2 17.3 0.67 7.8 17.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI78244.1 - 4.8 5.2 18.0 6.7 4.7 18.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 CDI78244.1 - 5.1 5.9 10.4 7.4 5.3 10.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.12 CDI78244.1 - 7 6.4 22.0 15 5.3 22.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CDI78244.1 - 8.8 5.0 18.5 14 4.3 18.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PAN_1 PF00024.26 CDI78245.1 - 0.69 9.9 6.8 0.087 12.8 1.6 2.2 2 0 0 2 2 2 0 PAN domain CLN3 PF02487.17 CDI78245.1 - 0.76 8.8 8.2 1.1 8.3 8.2 1.2 1 0 0 1 1 1 0 CLN3 protein LMBR1 PF04791.16 CDI78245.1 - 2.5 6.9 6.4 4.1 6.2 6.4 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 CDI78245.1 - 4.9 6.6 28.7 0.99 8.9 23.9 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit Neur_chan_memb PF02932.16 CDI78245.1 - 7.4 6.6 10.1 16 5.4 10.1 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DcpS_C PF11969.8 CDI78246.1 - 2.1e-06 28.2 0.0 0.0003 21.3 0.0 2.5 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding Rad50_zn_hook PF04423.14 CDI78246.1 - 0.027 14.3 0.3 0.91 9.4 0.0 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif Ribosomal_60s PF00428.19 CDI78246.1 - 4.3 8.0 8.6 12 6.6 8.6 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Macoilin PF09726.9 CDI78247.1 - 0.1 11.1 14.0 0.13 10.8 14.0 1.1 1 0 0 1 1 1 0 Macoilin family Nuc_sug_transp PF04142.15 CDI78249.1 - 3.5e-99 331.9 11.7 4.3e-99 331.6 11.7 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 CDI78249.1 - 9.3e-06 25.1 3.8 1.9e-05 24.1 3.8 1.5 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 CDI78249.1 - 3.4e-05 24.0 31.4 0.0019 18.4 10.7 2.7 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 CDI78249.1 - 3.4e-05 22.9 2.4 3.4e-05 22.9 2.4 1.6 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 CDI78249.1 - 8.6e-05 21.9 9.9 0.00054 19.3 8.3 2.5 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.6 CDI78249.1 - 0.00027 20.6 7.4 0.0015 18.2 7.4 2.2 1 1 0 1 1 1 1 Putative multidrug resistance efflux transporter TPT PF03151.16 CDI78249.1 - 0.082 12.2 7.3 0.27 10.5 2.0 2.7 1 1 1 2 2 2 0 Triose-phosphate Transporter family LCCL PF03815.19 CDI78250.1 - 5.4e-31 106.6 0.3 4.9e-17 61.8 0.0 2.2 1 1 1 2 2 2 2 LCCL domain TFIIA PF03153.13 CDI78251.1 - 4.1 7.3 6.5 4.3 7.2 6.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LCCL PF03815.19 CDI78252.1 - 1.6e-10 40.9 0.0 4e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 LCCL domain SRCR PF00530.18 CDI78252.1 - 2.6e-09 37.5 3.2 8.3e-09 35.9 0.5 2.7 2 1 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 CDI78252.1 - 2.1e-05 25.0 0.8 6.5e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Ribosomal_L32e PF01655.18 CDI78253.1 - 4.8e-46 155.6 0.4 8.1e-46 154.9 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L32 Pkinase PF00069.25 CDI78254.1 - 1.7e-35 122.7 0.0 4.8e-33 114.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78254.1 - 4.7e-20 72.0 0.0 7e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI78254.1 - 1.9e-07 30.7 0.0 3.7e-07 29.7 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDI78254.1 - 2.7e-06 26.4 0.0 3.8e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI78254.1 - 0.00015 21.8 0.5 0.0005 20.1 0.1 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDI78254.1 - 0.044 12.7 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CDI78254.1 - 0.093 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDI78254.1 - 0.096 12.3 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase MMR_HSR1 PF01926.23 CDI78256.1 - 1.5e-14 54.1 0.0 3.3e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI78256.1 - 2.3e-05 24.4 0.0 0.073 13.0 0.0 2.7 3 0 0 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 CDI78256.1 - 0.0016 18.0 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDI78256.1 - 0.004 16.7 0.0 0.76 9.3 0.0 2.6 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDI78256.1 - 0.012 15.6 0.0 0.14 12.2 0.1 2.7 3 0 0 3 3 3 0 Dynamin family GNAT_like PF18407.1 CDI78256.1 - 1 9.8 6.7 0.94 9.9 3.2 2.8 2 0 0 2 2 2 0 GCN5-related N-acetyltransferase like domain ASFV_J13L PF05568.11 CDI78258.1 - 0.19 11.5 1.4 0.45 10.3 1.4 1.7 1 0 0 1 1 1 0 African swine fever virus J13L protein EB PF01683.18 CDI78260.1 - 3.5 8.0 16.3 1.3 9.3 0.4 4.1 4 0 0 4 4 4 0 EB module AIF_C PF14721.6 CDI78262.1 - 0.031 14.6 8.8 0.035 14.5 8.8 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SelP_N PF04592.14 CDI78262.1 - 0.04 13.3 19.7 0.041 13.3 19.7 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PTPRCAP PF15713.5 CDI78262.1 - 0.07 13.4 12.7 0.08 13.2 12.7 1.0 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CPSF100_C PF13299.6 CDI78262.1 - 0.12 12.5 9.8 0.13 12.5 9.8 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Orf78 PF06024.12 CDI78262.1 - 0.13 12.6 5.5 0.17 12.2 5.5 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Folate_carrier PF01770.18 CDI78262.1 - 0.18 10.5 8.8 0.18 10.5 8.8 1.0 1 0 0 1 1 1 0 Reduced folate carrier EIIBC-GUT_N PF03612.14 CDI78262.1 - 0.21 11.3 11.2 0.22 11.2 11.2 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5523 PF17661.1 CDI78262.1 - 0.26 11.0 11.9 0.26 10.9 11.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Peroxin-13_N PF04088.13 CDI78262.1 - 0.28 11.4 5.6 0.29 11.4 5.6 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region RR_TM4-6 PF06459.12 CDI78262.1 - 0.38 10.6 12.8 0.36 10.6 12.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 CDI78262.1 - 0.42 10.3 7.2 0.46 10.1 7.2 1.1 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 CDI78262.1 - 0.42 9.3 14.8 0.45 9.2 14.8 1.0 1 0 0 1 1 1 0 Presenilin PIP5K PF01504.18 CDI78262.1 - 0.45 9.7 11.0 0.5 9.6 11.0 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase CbtA PF09490.10 CDI78262.1 - 0.49 10.1 7.4 0.53 10.0 7.4 1.0 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) SpoIIP PF07454.11 CDI78262.1 - 0.54 9.7 12.9 0.54 9.7 12.9 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI78262.1 - 0.54 9.0 10.1 0.58 8.9 10.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MDM31_MDM32 PF08118.11 CDI78262.1 - 0.55 8.8 10.5 0.56 8.8 10.5 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Connexin PF00029.19 CDI78262.1 - 0.61 9.8 11.4 0.6 9.8 11.4 1.0 1 0 0 1 1 1 0 Connexin Glt_symporter PF03616.14 CDI78262.1 - 0.77 8.4 4.1 0.79 8.3 4.1 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Pex14_N PF04695.13 CDI78262.1 - 0.8 10.4 21.3 0.88 10.2 21.3 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CCDC53 PF10152.9 CDI78262.1 - 0.85 10.0 12.6 0.91 9.9 12.6 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Zip PF02535.22 CDI78262.1 - 0.87 8.7 12.7 0.91 8.7 12.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter dsRBD2 PF17842.1 CDI78262.1 - 0.88 9.8 8.5 0.94 9.7 8.5 1.1 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 V_ATPase_I PF01496.19 CDI78262.1 - 0.92 7.3 14.9 0.9 7.4 14.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_U57 PF05582.12 CDI78262.1 - 1.1 8.5 9.3 1.2 8.4 9.3 1.0 1 0 0 1 1 1 0 YabG peptidase U57 BRF1 PF07741.13 CDI78262.1 - 1.2 9.5 10.0 1.5 9.2 10.0 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain OATP PF03137.20 CDI78262.1 - 1.4 7.1 8.2 1.4 7.1 8.2 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TFB6 PF17110.5 CDI78262.1 - 1.5 8.5 7.8 1.7 8.4 7.8 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH EPL1 PF10513.9 CDI78262.1 - 1.7 9.0 16.0 2.1 8.7 16.0 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF2828 PF11443.8 CDI78262.1 - 1.8 6.6 13.0 1.8 6.6 13.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDHD PF02862.17 CDI78262.1 - 1.8 8.7 12.8 2 8.5 12.8 1.0 1 0 0 1 1 1 0 DDHD domain Nucleoside_tran PF01733.18 CDI78262.1 - 1.8 7.9 7.1 1.9 7.8 7.1 1.0 1 0 0 1 1 1 0 Nucleoside transporter Gti1_Pac2 PF09729.9 CDI78262.1 - 1.9 8.6 11.2 2 8.5 11.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3464 PF11947.8 CDI78262.1 - 1.9 8.2 12.1 2.2 8.0 12.1 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 FAM60A PF15396.6 CDI78262.1 - 2.3 8.2 10.8 2.5 8.1 10.8 1.0 1 0 0 1 1 1 0 Protein Family FAM60A CobT PF06213.12 CDI78262.1 - 2.4 7.5 18.2 2.7 7.3 18.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CSG2 PF16965.5 CDI78262.1 - 2.4 7.0 8.6 2.5 7.0 8.6 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Ureide_permease PF07168.11 CDI78262.1 - 2.6 6.7 7.5 2.8 6.6 7.5 1.0 1 0 0 1 1 1 0 Ureide permease DUF2464 PF10240.9 CDI78262.1 - 2.7 7.5 9.2 2.6 7.6 9.2 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 Band_3_cyto PF07565.13 CDI78262.1 - 2.9 7.6 15.2 2.9 7.6 15.2 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Baculo_PP31 PF05311.11 CDI78262.1 - 2.9 7.3 12.8 3.1 7.2 12.8 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Velvet PF11754.8 CDI78262.1 - 3.2 7.6 14.3 3.4 7.5 14.3 1.0 1 0 0 1 1 1 0 Velvet factor CLN3 PF02487.17 CDI78262.1 - 3.3 6.7 11.7 3.2 6.7 11.7 1.0 1 0 0 1 1 1 0 CLN3 protein ORC_WH_C PF18137.1 CDI78262.1 - 3.5 7.7 12.8 4.1 7.5 12.8 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Neur_chan_memb PF02932.16 CDI78262.1 - 3.8 7.5 12.6 4 7.4 12.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI78262.1 - 4 6.2 11.7 4.1 6.1 11.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter EOS1 PF12326.8 CDI78262.1 - 4.2 7.3 8.2 4.7 7.1 8.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein HCO3_cotransp PF00955.21 CDI78262.1 - 4.5 6.0 6.6 4.3 6.0 6.6 1.0 1 0 0 1 1 1 0 HCO3- transporter family Sec62 PF03839.16 CDI78262.1 - 4.5 6.7 10.7 4.9 6.6 10.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 eIF-3_zeta PF05091.12 CDI78262.1 - 4.8 6.0 17.6 5 6.0 17.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MDM10 PF12519.8 CDI78262.1 - 5.3 5.8 11.7 5.6 5.7 11.7 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2126 PF09899.9 CDI78262.1 - 5.8 4.9 11.7 5.7 4.9 11.7 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Kei1 PF08552.11 CDI78262.1 - 6.4 6.6 10.2 6.6 6.6 10.2 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 YABBY PF04690.13 CDI78262.1 - 6.4 7.3 14.4 7.2 7.2 14.4 1.1 1 0 0 1 1 1 0 YABBY protein DUF3112 PF11309.8 CDI78262.1 - 7.3 6.0 6.3 7.9 5.9 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Coilin_N PF15862.5 CDI78262.1 - 7.4 6.4 15.6 11 5.9 15.6 1.3 1 0 0 1 1 1 0 Coilin N-terminus Otopetrin PF03189.13 CDI78262.1 - 8.9 5.0 11.9 8.6 5.1 11.9 1.0 1 0 0 1 1 1 0 Otopetrin NicO PF03824.16 CDI78262.1 - 9.2 5.5 10.0 10 5.4 10.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein MMR1 PF08505.10 CDI78262.1 - 9.9 6.4 19.8 11 6.2 19.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SIR2 PF02146.17 CDI78263.1 - 4.1e-06 26.9 8.1 0.015 15.3 0.0 4.0 3 1 1 4 4 4 3 Sir2 family Presenilin PF01080.17 CDI78263.1 - 2.2 7.0 30.8 0.013 14.3 12.1 3.0 3 1 0 3 3 3 0 Presenilin AF-4 PF05110.13 CDI78265.1 - 0.00016 20.0 41.4 0.00016 20.0 41.4 6.1 4 1 1 6 6 6 1 AF-4 proto-oncoprotein SR-25 PF10500.9 CDI78265.1 - 0.0021 17.7 28.9 0.0021 17.7 28.9 9.9 9 3 1 10 10 10 3 Nuclear RNA-splicing-associated protein Rav1p_C PF12234.8 CDI78267.1 - 1.3e-17 63.5 0.4 6.1e-16 58.0 0.7 5.4 6 0 0 6 6 6 4 RAVE protein 1 C terminal BAF1_ABF1 PF04684.13 CDI78268.1 - 1.6 7.7 12.9 5.3 6.0 11.5 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor SAPS PF04499.15 CDI78268.1 - 7.2 5.3 6.9 47 2.6 6.6 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Surface_antigen PF11054.8 CDI78270.1 - 0.06 13.0 0.1 0.064 12.9 0.1 1.1 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI78271.1 - 2.2e-39 135.6 4.6 3.3e-39 135.0 4.6 1.2 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen BMC PF00936.19 CDI78271.1 - 0.0085 16.1 1.7 0.026 14.5 0.0 2.6 3 0 0 3 3 3 1 BMC domain Asp_protease PF09668.10 CDI78272.1 - 3.1e-50 169.1 0.0 4.5e-50 168.6 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI78272.1 - 3.1e-20 72.5 0.0 2.7e-19 69.5 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDI78272.1 - 1.4e-09 38.4 0.0 8e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 Aspartyl protease ubiquitin PF00240.23 CDI78272.1 - 5.8e-09 35.6 0.0 1.8e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family RVP_2 PF08284.11 CDI78272.1 - 7.8e-06 25.7 0.0 2.3e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 CDI78272.1 - 0.0013 18.5 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PLC-beta_C PF08703.10 CDI78272.1 - 0.0062 16.5 1.0 0.01 15.8 1.0 1.3 1 0 0 1 1 1 1 PLC-beta C terminal RVP PF00077.20 CDI78272.1 - 0.0088 16.3 0.0 0.026 14.8 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease DUF853 PF05872.12 CDI78273.1 - 0.22 10.1 0.0 0.33 9.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) TSP_1 PF00090.19 CDI78273.1 - 0.36 11.1 9.1 0.047 13.9 3.1 2.7 2 0 0 2 2 2 0 Thrombospondin type 1 domain ENTH PF01417.20 CDI78274.1 - 2.2e-26 92.4 0.0 3.1e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 CDI78274.1 - 0.27 10.2 0.0 0.43 9.5 0.0 1.2 1 0 0 1 1 1 0 ANTH domain V_ATPase_I PF01496.19 CDI78277.1 - 2.6e-235 783.1 0.1 1.2e-192 642.1 6.9 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family SAM_KSR1 PF13543.6 CDI78277.1 - 2.1 8.5 4.5 3.5 7.8 0.3 2.7 3 0 0 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 ISK_Channel PF02060.15 CDI78277.1 - 4 7.2 9.5 0.6 9.8 0.9 3.0 2 0 0 2 2 2 0 Slow voltage-gated potassium channel zf-RING_10 PF16685.5 CDI78278.1 - 0.013 15.6 8.1 0.026 14.6 8.1 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_3 PF13920.6 CDI78278.1 - 0.032 14.1 12.2 0.058 13.3 12.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI78278.1 - 0.054 13.5 11.2 0.18 11.8 11.3 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDI78278.1 - 0.14 12.1 13.9 0.28 11.0 13.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI78278.1 - 0.18 12.2 13.4 0.35 11.3 13.4 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 CDI78278.1 - 3.5 7.7 8.9 8.6 6.5 8.9 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDI78278.1 - 8.3 6.7 10.2 24 5.2 10.2 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING PP2C PF00481.21 CDI78279.1 - 8.6e-06 25.6 0.1 2.6e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 Protein phosphatase 2C Chorismate_synt PF01264.21 CDI78279.1 - 0.001 17.9 2.2 0.0014 17.4 2.2 1.2 1 0 0 1 1 1 1 Chorismate synthase Apt1 PF10351.9 CDI78279.1 - 4.9 5.9 5.1 6.5 5.5 5.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Secretin_N_2 PF07655.13 CDI78279.1 - 7.2 7.2 13.5 12 6.5 13.5 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Epimerase PF01370.21 CDI78281.1 - 6.8e-22 78.1 0.0 8.1e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDI78281.1 - 3e-21 76.2 0.0 4.9e-21 75.5 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDI78281.1 - 0.00085 18.5 0.0 0.00098 18.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDI78281.1 - 0.084 12.0 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein RSRP PF17069.5 CDI78283.1 - 2.4 7.6 17.6 4.6 6.7 17.6 1.4 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Peptidase_S64 PF08192.11 CDI78283.1 - 2.5 6.5 4.3 3 6.2 4.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 CDI78283.1 - 3.9 6.2 8.5 4.5 6.0 8.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI78283.1 - 4.6 6.7 16.3 7.9 5.9 16.3 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CPW_WPC PF09717.10 CDI78285.1 - 2.1e-12 47.8 8.2 3e-05 24.9 1.8 3.6 2 1 0 2 2 2 2 Plasmodium falciparum domain of unknown function (CPW_WPC) SUIM_assoc PF16619.5 CDI78285.1 - 0.0025 17.8 10.3 0.019 15.0 0.2 2.4 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI78285.1 - 0.52 9.9 9.0 1.7 8.2 1.2 2.0 2 0 0 2 2 2 0 Spt20 family zf-rbx1 PF12678.7 CDI78285.1 - 0.84 10.0 5.2 13 6.2 0.1 2.4 2 0 0 2 2 2 0 RING-H2 zinc finger domain Inj_translocase PF16928.5 CDI78285.1 - 5.9 6.3 12.3 2.2 7.7 3.5 2.1 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome SLBP_RNA_bind PF15247.6 CDI78286.1 - 7.2e-19 67.7 2.3 7.2e-19 67.7 2.3 3.2 3 1 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain SR-25 PF10500.9 CDI78286.1 - 0.0006 19.5 16.9 0.0006 19.5 16.9 3.7 4 0 0 4 4 4 1 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDI78286.1 - 3.1 8.2 30.7 1.8 8.9 8.2 3.9 3 0 0 3 3 3 0 Early growth response N-terminal domain GBP PF02263.19 CDI78288.1 - 1.5e-10 40.8 1.2 1.5e-10 40.8 1.2 3.3 3 1 0 3 3 2 1 Guanylate-binding protein, N-terminal domain TFIIA PF03153.13 CDI78288.1 - 0.0028 17.7 59.0 0.077 13.0 14.0 3.5 3 1 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit ABC2_membrane_2 PF12679.7 CDI78288.1 - 0.0083 15.4 0.3 0.0083 15.4 0.3 2.4 3 0 0 3 3 3 1 ABC-2 family transporter protein DUF2723 PF11028.8 CDI78288.1 - 0.086 12.8 0.1 0.086 12.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2723) US22 PF02393.16 CDI78288.1 - 0.11 12.7 0.3 4.4 7.6 0.0 2.6 2 0 0 2 2 2 0 US22 like RPA43_OB PF17875.1 CDI78288.1 - 0.58 10.8 6.6 0.62 10.7 1.2 3.1 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I Velvet PF11754.8 CDI78288.1 - 0.6 10.0 21.5 0.28 11.1 2.1 4.0 3 1 0 3 3 3 0 Velvet factor PIP5K PF01504.18 CDI78288.1 - 2.1 7.5 11.1 2.3 7.4 6.3 2.4 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase OATP PF03137.20 CDI78288.1 - 2.2 6.5 4.9 2 6.6 1.7 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family FAM176 PF14851.6 CDI78288.1 - 3.4 7.3 12.4 0.041 13.5 0.7 3.0 3 1 1 4 4 4 0 FAM176 family REF PF05755.12 CDI78288.1 - 7.3 6.3 9.2 23 4.7 2.9 3.0 2 1 0 2 2 2 0 Rubber elongation factor protein (REF) RskA PF10099.9 CDI78293.1 - 0.0066 16.8 2.2 0.0066 16.8 2.2 11.0 3 3 5 9 9 9 2 Anti-sigma-K factor rskA Ribosom_S30AE_C PF16321.5 CDI78293.1 - 0.28 10.9 0.2 0.54 10.0 0.2 1.4 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus SOG2 PF10428.9 CDI78294.1 - 1.7 7.7 10.2 2.4 7.3 10.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Gar1 PF04410.14 CDI78295.1 - 1.9e-23 82.9 0.0 4.4e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region RPN13_C PF16550.5 CDI78295.1 - 4.4e-11 42.9 3.6 4.4e-11 42.9 3.6 2.7 2 1 0 2 2 2 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 CDI78295.1 - 5.5e-09 36.4 0.0 1.1e-08 35.5 0.0 1.6 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Activator_LAG-3 PF11498.8 CDI78295.1 - 0.006 15.6 5.6 0.006 15.6 5.6 2.2 2 0 0 2 2 2 1 Transcriptional activator LAG-3 RTTN_N PF14726.6 CDI78295.1 - 1.9 9.3 5.7 4.9 8.0 0.1 2.5 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning GHMP_kinases_N PF00288.26 CDI78295.1 - 8.4 6.7 11.5 0.051 13.8 2.2 2.1 2 0 0 2 2 2 0 GHMP kinases N terminal domain UCH PF00443.29 CDI78297.1 - 2.8e-32 112.2 4.6 3.1e-32 112.1 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDI78297.1 - 5.4e-16 59.1 8.3 1.3e-12 47.9 0.0 3.9 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase RNase_H2_suC PF08615.11 CDI78297.1 - 0.0039 17.4 0.4 0.013 15.7 0.4 1.9 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Tau95_N PF17682.1 CDI78297.1 - 0.88 9.8 7.9 0.53 10.5 4.3 2.6 2 0 0 2 2 2 0 Tau95 Triple barrel domain Peroxin-13_N PF04088.13 CDI78297.1 - 1.7 8.9 13.4 0.13 12.5 4.5 3.4 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Dala_Dala_lig_N PF01820.21 CDI78297.1 - 3.7 8.1 5.4 18 5.9 1.4 2.9 2 1 0 2 2 2 0 D-ala D-ala ligase N-terminus Secretin_N_2 PF07655.13 CDI78297.1 - 4.6 7.9 13.4 11 6.6 6.0 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain MFS_1 PF07690.16 CDI78298.1 - 6.8e-22 77.9 41.9 2.8e-19 69.2 18.7 3.3 1 1 1 3 3 3 3 Major Facilitator Superfamily OATP PF03137.20 CDI78298.1 - 1.1e-19 70.1 0.6 7.2e-16 57.6 0.0 2.8 1 1 2 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 CDI78298.1 - 3.7e-05 22.8 0.0 3.7e-05 22.8 0.0 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter Vut_1 PF02592.15 CDI78298.1 - 0.0051 17.2 0.3 0.0051 17.2 0.3 3.2 3 1 1 4 4 4 1 Putative vitamin uptake transporter Phage_holin_2_3 PF16080.5 CDI78298.1 - 0.25 11.1 0.0 0.25 11.1 0.0 2.7 3 0 0 3 3 3 0 Bacteriophage holin family HP1 TFIIA PF03153.13 CDI78298.1 - 4.9 7.1 25.2 0.6 10.0 13.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit S4 PF01479.25 CDI78299.1 - 2.2e-12 46.5 0.4 2.2e-12 46.5 0.4 2.1 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 CDI78299.1 - 3.2e-06 28.0 1.2 5e-06 27.3 0.8 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DOT1 PF08123.13 CDI78300.1 - 5.1e-05 22.9 0.0 8.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 DmpG_comm PF07836.11 CDI78300.1 - 0.12 12.0 0.4 0.64 9.6 0.1 2.2 2 0 0 2 2 2 0 DmpG-like communication domain EGF_2 PF07974.13 CDI78301.1 - 2.4e-24 85.4 181.0 3e-05 24.3 12.3 11.2 9 2 2 11 11 11 9 EGF-like domain hEGF PF12661.7 CDI78301.1 - 7.2e-13 48.6 119.5 0.0068 17.0 7.2 11.8 11 0 0 11 11 11 9 Human growth factor-like EGF EGF PF00008.27 CDI78301.1 - 0.0016 18.7 46.0 0.0065 16.8 8.7 10.6 9 2 1 10 10 10 5 EGF-like domain EF-hand_9 PF14658.6 CDI78304.1 - 0.065 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Ank_2 PF12796.7 CDI78305.1 - 2.4e-38 130.6 0.3 2.9e-13 50.2 0.1 5.7 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI78305.1 - 3.3e-29 100.9 0.1 1.4e-05 25.6 0.0 7.4 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI78305.1 - 2e-27 94.9 4.4 0.00013 22.2 0.0 7.3 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI78305.1 - 6.2e-26 87.6 0.6 0.032 14.8 0.0 9.9 10 0 0 10 10 10 6 Ankyrin repeat Ank PF00023.30 CDI78305.1 - 3.3e-19 68.4 1.7 0.08 13.4 0.0 10.0 11 0 0 11 11 11 5 Ankyrin repeat TFIIA PF03153.13 CDI78305.1 - 6.2 6.7 24.6 1.8 8.5 8.9 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI78305.1 - 7.1 7.1 10.0 1.8 9.0 3.5 2.5 2 0 0 2 2 2 0 AAA domain 5_nucleotid_C PF02872.18 CDI78306.1 - 3.6e-37 128.0 0.0 8.9e-37 126.7 0.0 1.7 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CDI78306.1 - 7e-06 26.7 0.8 9.3e-05 23.0 0.8 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DASH_Dad4 PF08650.10 CDI78307.1 - 0.041 13.9 0.4 0.095 12.7 0.4 1.5 1 0 0 1 1 1 0 DASH complex subunit Dad4 DUF2203 PF09969.9 CDI78307.1 - 0.25 12.1 3.3 1.8 9.3 1.7 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) FapA PF03961.13 CDI78307.1 - 0.54 8.8 1.0 0.81 8.2 1.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Not3 PF04065.15 CDI78307.1 - 0.66 9.4 7.5 1.1 8.6 7.5 1.2 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component ELO PF01151.18 CDI78308.1 - 0.015 14.8 1.7 0.038 13.5 1.7 1.7 1 0 0 1 1 1 0 GNS1/SUR4 family Ytca PF17090.5 CDI78308.1 - 0.6 10.7 4.7 1 9.9 0.2 2.9 2 0 0 2 2 2 0 Uncharacterised protein family Fcf1 PF04900.12 CDI78309.1 - 4.2e-27 94.4 1.3 5.5e-27 94.1 0.1 1.7 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 CDI78309.1 - 1.6e-09 38.0 2.3 2.3e-09 37.6 0.2 2.2 2 1 0 2 2 2 1 PIN like domain SWI-SNF_Ssr4 PF08549.10 CDI78310.1 - 0.029 13.1 1.7 0.033 12.9 1.7 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Sec3_C_2 PF15278.6 CDI78310.1 - 0.068 13.5 0.1 0.13 12.7 0.1 1.3 1 0 0 1 1 1 0 Sec3 exocyst complex subunit LRR19-TM PF15176.6 CDI78310.1 - 0.15 12.0 0.1 0.26 11.3 0.1 1.5 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain CODH_A_N PF18537.1 CDI78311.1 - 0.021 14.8 0.1 0.063 13.3 0.0 1.8 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain Macoilin PF09726.9 CDI78311.1 - 0.04 12.5 10.2 0.048 12.2 10.2 1.0 1 0 0 1 1 1 0 Macoilin family DUF745 PF05335.13 CDI78311.1 - 0.12 12.1 12.2 0.6 9.8 2.7 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Lectin_N PF03954.14 CDI78311.1 - 0.18 11.6 4.0 4 7.2 4.0 2.3 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain SPACA9 PF15120.6 CDI78311.1 - 0.56 10.0 7.7 1.6 8.5 4.9 2.6 1 1 1 2 2 2 0 Sperm acrosome-associated protein 9 DUF334 PF03904.13 CDI78311.1 - 2.2 7.8 7.9 4.8 6.7 7.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF334) TMPIT PF07851.13 CDI78311.1 - 4.5 6.4 6.7 6.1 6.0 6.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 CDI78311.1 - 7.3 6.6 18.5 73 3.4 18.5 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ApoLp-III PF07464.11 CDI78314.1 - 0.86 9.7 7.9 6.3 6.9 1.3 2.8 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) SET PF00856.28 CDI78314.1 - 1 9.7 4.1 9.4 6.6 0.0 3.8 3 1 0 3 3 3 0 SET domain Ank_2 PF12796.7 CDI78315.1 - 3.2e-15 56.5 0.2 5.9e-07 30.0 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI78315.1 - 2.3e-13 50.3 4.9 0.021 15.4 0.1 5.3 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI78315.1 - 1.4e-11 44.4 0.9 0.85 10.0 0.0 5.7 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 CDI78315.1 - 3.3e-07 30.4 2.9 0.14 12.7 0.2 5.6 6 0 0 6 6 6 2 Ankyrin repeat Ank_3 PF13606.6 CDI78315.1 - 6.6e-06 26.1 0.6 0.39 11.4 0.1 5.6 6 0 0 6 6 6 1 Ankyrin repeat TraT PF05818.12 CDI78317.1 - 0.016 14.9 0.6 0.016 14.9 0.6 3.5 4 1 0 4 4 4 0 Enterobacterial TraT complement resistance protein Lact-deh-memb PF09330.11 CDI78317.1 - 0.05 12.9 0.2 0.29 10.4 0.1 2.0 2 0 0 2 2 2 0 D-lactate dehydrogenase, membrane binding Adap_comp_sub PF00928.21 CDI78319.1 - 1.3e-62 211.6 0.0 3.8e-52 177.3 0.0 2.4 1 1 1 2 2 2 2 Adaptor complexes medium subunit family PGDH_C PF16896.5 CDI78319.1 - 0.094 12.7 0.0 0.23 11.4 0.0 1.6 2 0 0 2 2 2 0 Phosphogluconate dehydrogenase (decarboxylating) C-term PCI PF01399.27 CDI78322.1 - 1e-15 58.1 0.5 1.7e-14 54.2 0.0 2.6 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 CDI78322.1 - 1.2e-08 34.9 0.2 3.5e-08 33.4 0.2 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Not3 PF04065.15 CDI78322.1 - 0.038 13.4 3.5 0.2 11.1 0.3 2.5 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Rep_3 PF01051.21 CDI78322.1 - 0.92 9.3 4.2 1.1 9.0 2.9 1.7 2 0 0 2 2 2 0 Initiator Replication protein PIGA PF08288.12 CDI78323.1 - 2e-38 130.9 3.7 2e-38 130.9 3.7 1.8 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CDI78323.1 - 1.7e-23 83.5 5.4 3.2e-23 82.6 5.4 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CDI78323.1 - 1e-10 41.4 0.0 2e-10 40.5 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDI78323.1 - 1.1e-10 42.2 0.1 1.3e-09 38.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CDI78323.1 - 5.5e-10 39.8 0.1 1.3e-09 38.5 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 CDI78323.1 - 1.2e-06 28.6 1.1 1.9e-06 27.9 1.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CDI78323.1 - 6.9e-06 26.4 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 CKS PF01111.19 CDI78324.1 - 5.4e-22 77.8 0.6 1.5e-21 76.5 0.0 2.1 3 0 0 3 3 3 1 Cyclin-dependent kinase regulatory subunit Mur_ligase_M PF08245.12 CDI78324.1 - 0.037 14.0 0.0 8.4 6.3 0.0 2.3 2 0 0 2 2 2 0 Mur ligase middle domain Macro PF01661.21 CDI78324.1 - 0.043 13.8 0.0 15 5.7 0.0 2.6 2 1 0 2 2 2 0 Macro domain PaRep2b PF07775.11 CDI78324.1 - 0.13 10.7 0.4 9.4 4.6 0.0 2.0 2 0 0 2 2 2 0 PaRep2b protein HTH_16 PF12645.7 CDI78324.1 - 0.19 11.8 0.3 32 4.7 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Borrelia_rep PF03183.13 CDI78324.1 - 1.8 8.7 3.7 38 4.5 0.3 2.4 2 0 0 2 2 2 0 Borrelia repeat protein Ribosomal_60s PF00428.19 CDI78325.1 - 0.066 13.8 9.0 0.11 13.1 9.0 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Presenilin PF01080.17 CDI78325.1 - 0.15 10.8 0.6 0.18 10.5 0.6 1.1 1 0 0 1 1 1 0 Presenilin DUF3138 PF11336.8 CDI78325.1 - 7.8 5.0 8.6 9.4 4.7 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TT_ORF2 PF02957.15 CDI78325.1 - 9.7 7.1 12.0 1.6 9.7 2.2 2.3 1 1 1 2 2 2 0 TT viral ORF2 DUF2227 PF09988.9 CDI78326.1 - 0.15 11.9 1.0 0.61 9.9 1.0 2.0 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) WD40 PF00400.32 CDI78328.1 - 4.9e-17 62.0 16.3 0.00023 21.9 0.4 7.7 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78328.1 - 9.9e-07 29.0 0.0 0.88 9.9 0.0 5.7 7 0 0 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2722 PF10846.8 CDI78328.1 - 0.00091 18.3 4.6 0.00091 18.3 4.6 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI78328.1 - 0.0032 17.1 20.7 0.01 15.5 10.9 2.5 3 0 0 3 3 3 2 Spt20 family Nup160 PF11715.8 CDI78328.1 - 0.0089 14.7 0.2 0.015 13.9 0.2 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDI78328.1 - 0.056 12.4 0.3 0.12 11.3 0.3 1.6 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TMEM247 PF15444.6 CDI78328.1 - 0.13 12.3 7.6 0.031 14.3 4.0 1.8 2 0 0 2 2 2 0 Transmembrane protein 247 LCE PF14672.6 CDI78328.1 - 0.24 12.0 0.1 0.24 12.0 0.1 6.6 7 0 0 7 7 6 0 Late cornified envelope Med15 PF09606.10 CDI78328.1 - 0.57 8.8 21.8 0.97 8.0 21.8 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.14 CDI78328.1 - 0.93 9.4 5.8 1.6 8.6 5.8 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RLL PF10036.9 CDI78328.1 - 4.8 7.0 11.0 0.49 10.2 4.4 2.0 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein DUF4667 PF15700.5 CDI78330.1 - 4.6e-06 26.9 7.1 0.037 14.1 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4667) DUF1645 PF07816.11 CDI78330.1 - 0.0045 17.6 8.0 0.16 12.5 2.3 3.0 2 1 0 2 2 2 2 Protein of unknown function (DUF1645) Secretin_N_2 PF07655.13 CDI78330.1 - 0.28 11.7 21.3 2.1 8.9 2.9 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Lin-8 PF03353.15 CDI78330.1 - 0.86 9.1 6.6 0.81 9.2 2.8 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist AF-4 PF05110.13 CDI78330.1 - 1.3 7.0 19.5 0.097 10.8 9.3 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein YfhO PF09586.10 CDI78330.1 - 2.4 6.3 4.4 0.65 8.2 0.6 1.7 2 0 0 2 2 2 0 Bacterial membrane protein YfhO TFIIA PF03153.13 CDI78330.1 - 6.7 6.6 44.9 0.14 12.1 22.5 3.2 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Rhomboid PF01694.22 CDI78331.1 - 2.1e-25 89.5 14.3 2.1e-25 89.5 14.3 2.2 2 0 0 2 2 2 1 Rhomboid family RCC1 PF00415.18 CDI78331.1 - 6.2e-10 39.5 5.7 1.7e-05 25.3 0.3 5.7 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat DUF2722 PF10846.8 CDI78331.1 - 0.0039 16.2 0.6 0.0039 16.2 0.6 4.2 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) RCC1_2 PF13540.6 CDI78331.1 - 0.012 15.4 23.5 0.013 15.2 0.1 6.3 7 0 0 7 7 7 0 Regulator of chromosome condensation (RCC1) repeat TFIIA PF03153.13 CDI78331.1 - 0.2 11.6 48.5 0.16 12.0 4.2 3.3 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI78331.1 - 0.61 9.9 17.5 0.89 9.4 6.6 2.5 2 0 0 2 2 2 0 SPX domain Hydin_ADK PF17213.3 CDI78331.1 - 3.7 7.8 17.3 11 6.3 0.0 3.9 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Apt1 PF10351.9 CDI78331.1 - 4 6.2 10.7 1.7 7.4 4.0 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain U3_snoRNA_assoc PF08297.11 CDI78331.1 - 4.2 8.1 7.7 51 4.7 0.0 3.0 2 0 0 2 2 2 0 U3 snoRNA associated eIF-3_zeta PF05091.12 CDI78331.1 - 6.3 5.6 16.2 1.8 7.4 8.3 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Corona_nucleoca PF00937.18 CDI78334.1 - 0.32 10.0 9.8 0.4 9.7 9.8 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Apt1 PF10351.9 CDI78334.1 - 0.45 9.3 7.6 0.5 9.2 7.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 CDI78334.1 - 1.5 8.6 9.7 1.9 8.3 9.7 1.1 1 0 0 1 1 1 0 SPX domain SET PF00856.28 CDI78335.1 - 2e-18 67.4 0.0 2e-18 67.4 0.0 7.1 4 2 1 7 7 7 1 SET domain Orf78 PF06024.12 CDI78335.1 - 1.8 8.9 0.0 1.8 8.9 0.0 6.3 6 1 1 7 7 7 0 Orf78 (ac78) AMP-binding PF00501.28 CDI78338.1 - 3.3e-18 65.5 0.0 4.7e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Hep_59 PF07052.11 CDI78340.1 - 1.4e-20 74.0 2.8 1.4e-20 74.0 2.8 2.5 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 DUF456 PF04306.13 CDI78341.1 - 0.012 15.8 4.7 0.034 14.4 4.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF456) DUF5316 PF17247.2 CDI78341.1 - 0.057 13.4 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5316) Romo1 PF10247.9 CDI78341.1 - 0.32 11.4 4.2 0.92 9.9 4.2 1.8 1 1 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF3685 PF12452.8 CDI78341.1 - 0.51 10.0 3.7 0.28 10.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3685) DUF1269 PF06897.12 CDI78341.1 - 0.72 10.2 8.9 0.74 10.1 6.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Gly-zipper_YMGG PF13441.6 CDI78341.1 - 1.1 9.0 29.1 6.2 6.6 29.1 2.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper YscJ_FliF_C PF08345.11 CDI78341.1 - 2.1 8.7 9.7 0.13 12.6 0.4 3.3 3 0 0 3 3 3 0 Flagellar M-ring protein C-terminal Bacteriocin_IIc PF10439.9 CDI78341.1 - 8.3 6.6 23.1 28 4.9 23.1 1.9 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Hamartin PF04388.12 CDI78343.1 - 4.4 5.8 11.2 5.1 5.6 11.2 1.2 1 0 0 1 1 1 0 Hamartin protein Autophagy_act_C PF03987.15 CDI78345.1 - 1.6e-21 76.7 0.2 2.5e-21 76.0 0.2 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_N PF03986.13 CDI78345.1 - 2e-14 53.7 0.1 3.2e-14 53.1 0.1 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 CDI78345.1 - 1.1e-12 47.2 2.4 1.8e-12 46.5 2.4 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal DUF5378 PF17349.2 CDI78346.1 - 0.034 13.5 0.1 0.043 13.2 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) DUF5367 PF17329.2 CDI78346.1 - 0.055 13.6 0.5 0.11 12.7 0.1 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5367) DUF2631 PF10939.8 CDI78346.1 - 0.37 10.7 1.3 2.4 8.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2631) Allantoicase PF03561.15 CDI78347.1 - 0.14 12.1 0.0 0.14 12.1 0.0 6.1 5 3 2 7 7 7 0 Allantoicase repeat ISAV_HA PF06215.11 CDI78348.1 - 0.15 11.2 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin JAB PF01398.21 CDI78349.1 - 3.2e-23 81.9 0.3 1.1e-22 80.2 0.3 1.9 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CDI78349.1 - 0.0002 21.1 0.1 0.00059 19.6 0.1 1.8 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain Ribosomal_S26e PF01283.19 CDI78350.1 - 8.8e-49 164.4 5.6 1e-48 164.2 5.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.7 CDI78350.1 - 0.016 15.7 1.3 0.04 14.5 1.3 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain PK PF00224.21 CDI78351.1 - 7e-146 485.6 0.7 9.4e-146 485.1 0.7 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDI78351.1 - 2.9e-31 108.1 0.4 7.8e-31 106.7 0.4 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CDI78351.1 - 0.0034 16.5 0.7 0.011 14.9 0.1 2.2 2 1 1 3 3 3 1 HpcH/HpaI aldolase/citrate lyase family Vps8 PF12816.7 CDI78351.1 - 0.041 13.4 0.1 0.071 12.6 0.1 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Dor1 PF04124.12 CDI78352.1 - 7.6e-11 41.3 0.6 2e-10 39.9 0.2 1.8 2 0 0 2 2 2 1 Dor1-like family Exo84_C PF16528.5 CDI78352.1 - 0.0015 18.3 0.0 0.0045 16.8 0.0 1.7 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Sec1 PF00995.23 CDI78353.1 - 1.1e-27 97.5 0.9 3e-22 79.6 0.2 2.9 1 1 1 2 2 2 2 Sec1 family SPOUT_MTase PF02590.17 CDI78353.1 - 0.0031 17.5 0.1 0.034 14.1 0.0 2.2 2 0 0 2 2 2 1 Predicted SPOUT methyltransferase DUF1573 PF07610.11 CDI78354.1 - 5.2e-05 23.2 0.0 0.00013 22.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1573) DSPc PF00782.20 CDI78355.1 - 1.3e-23 83.3 0.0 2e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDI78355.1 - 0.0027 17.9 0.5 0.0066 16.6 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 CDI78355.1 - 0.0031 17.1 0.0 0.0054 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Zn_Tnp_IS91 PF14319.6 CDI78355.1 - 0.079 13.0 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Transposase zinc-binding domain Proteasome PF00227.26 CDI78356.1 - 3.1e-59 199.7 0.0 3.8e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDI78356.1 - 2e-13 49.8 0.2 3.4e-13 49.0 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GM_CSF PF01109.17 CDI78356.1 - 0.017 15.3 0.1 0.042 14.0 0.0 1.7 2 0 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor EF-hand_8 PF13833.6 CDI78357.1 - 6.4e-32 109.2 5.5 3.7e-16 58.7 0.6 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 CDI78357.1 - 4e-31 104.2 5.8 1.7e-09 36.5 0.7 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 CDI78357.1 - 7.9e-28 96.7 0.6 3.6e-17 62.6 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CDI78357.1 - 1.5e-19 68.5 3.0 1.8e-05 24.0 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDI78357.1 - 1.6e-19 68.1 3.0 4.2e-08 32.5 0.0 4.4 4 1 0 4 4 4 3 EF-hand domain EF-hand_9 PF14658.6 CDI78357.1 - 7.6e-11 42.2 0.1 8.5e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDI78357.1 - 1e-07 31.9 0.2 0.00026 20.9 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 CDI78357.1 - 2.1e-05 24.5 0.0 0.033 14.2 0.0 2.4 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 CDI78357.1 - 3.2e-05 24.7 0.0 0.00059 20.7 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 CDI78357.1 - 8.8e-05 22.8 0.0 0.011 16.1 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_Rpb4 PF03874.16 CDI78357.1 - 0.0026 18.1 0.7 1.4 9.3 0.2 2.3 2 0 0 2 2 2 2 RNA polymerase Rpb4 DUF1103 PF06513.11 CDI78357.1 - 0.0036 16.9 0.6 0.0047 16.6 0.6 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Dockerin_1 PF00404.18 CDI78357.1 - 0.011 15.9 3.3 0.12 12.6 0.6 2.5 1 1 2 3 3 3 0 Dockerin type I domain EFhand_Ca_insen PF08726.10 CDI78357.1 - 0.013 15.6 0.1 0.03 14.4 0.0 1.8 2 1 0 2 2 2 0 Ca2+ insensitive EF hand SurA_N_2 PF13623.6 CDI78357.1 - 0.015 15.1 0.4 0.66 9.8 0.1 2.1 1 1 1 2 2 2 0 SurA N-terminal domain YqeY PF09424.10 CDI78357.1 - 0.031 14.4 0.2 0.083 13.0 0.2 1.7 1 1 1 2 2 2 0 Yqey-like protein TetR_C_7 PF14246.6 CDI78357.1 - 0.044 13.8 0.0 4.2 7.4 0.0 2.3 2 1 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain DUF5580 PF17743.1 CDI78357.1 - 0.053 12.1 0.0 0.054 12.0 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) FGAR-AT_linker PF18072.1 CDI78357.1 - 0.062 13.8 0.2 1.9 9.1 0.0 2.4 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain Poly_export PF02563.16 CDI78357.1 - 0.16 12.2 0.0 3.8 7.8 0.0 2.3 1 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein Ribosomal_S10 PF00338.22 CDI78358.1 - 1.4e-07 31.6 0.1 1.1e-05 25.5 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein S10p/S20e DUF1922 PF09082.10 CDI78358.1 - 0.077 13.3 0.0 0.13 12.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1922) TPR_5 PF12688.7 CDI78358.1 - 0.13 12.5 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Tetratrico peptide repeat Ribosomal_L35Ae PF01247.18 CDI78359.1 - 5.4e-44 148.3 0.3 6.6e-44 148.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CDI78359.1 - 0.051 13.8 0.1 5.3 7.3 0.0 2.3 2 0 0 2 2 2 0 RimM N-terminal domain OMPdecase PF00215.24 CDI78360.1 - 6.7e-10 38.9 0.0 3.1e-07 30.2 0.0 2.5 1 1 1 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family HEAT PF02985.22 CDI78360.1 - 1.3e-06 28.2 25.1 0.04 14.2 0.1 9.0 9 1 0 9 9 9 2 HEAT repeat HEAT_EZ PF13513.6 CDI78360.1 - 6.8e-06 26.5 0.8 6.8e-06 26.5 0.8 7.6 8 1 1 9 9 9 1 HEAT-like repeat MMS19_C PF12460.8 CDI78360.1 - 0.00056 19.1 0.1 1.4 7.9 0.0 4.0 4 1 1 5 5 5 2 RNAPII transcription regulator C-terminal IBN_N PF03810.19 CDI78360.1 - 0.0008 19.3 0.6 0.0044 16.9 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 CDI78360.1 - 0.031 14.6 23.8 0.52 10.7 0.4 7.4 6 2 1 7 7 7 0 HEAT repeats PEARLI-4 PF05278.12 CDI78360.1 - 0.11 12.1 0.4 0.49 10.0 0.2 2.1 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) UME PF08064.13 CDI78360.1 - 0.97 9.4 3.3 42 4.1 0.0 4.3 5 0 0 5 5 5 0 UME (NUC010) domain Cohesin_HEAT PF12765.7 CDI78360.1 - 5.9 7.3 8.2 34 4.9 0.1 3.8 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CwfJ_C_1 PF04677.15 CDI78361.1 - 3.1e-26 91.7 0.0 5.4e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 RRM_1 PF00076.22 CDI78361.1 - 7.4e-08 32.1 0.0 1.7e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CwfJ_C_2 PF04676.14 CDI78361.1 - 5.6e-07 30.4 0.0 5.6e-07 30.4 0.0 3.0 3 0 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 SUIM_assoc PF16619.5 CDI78361.1 - 0.00052 20.0 25.7 0.049 13.7 4.0 4.1 3 0 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 Ank_4 PF13637.6 CDI78362.1 - 2.2e-26 91.9 2.4 1.8e-08 34.7 0.1 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI78362.1 - 6.9e-25 87.5 0.0 4.4e-11 43.2 0.0 3.5 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 CDI78362.1 - 1.4e-19 69.5 9.3 0.0046 17.3 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 CDI78362.1 - 5.8e-18 63.1 1.0 0.047 14.2 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat RNA_GG_bind PF10258.9 CDI78362.1 - 4.4e-15 55.5 0.0 1.1e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 PHAX RNA-binding domain Ank_5 PF13857.6 CDI78362.1 - 1.8e-11 44.0 4.3 0.18 12.2 0.0 5.2 3 1 2 5 5 5 5 Ankyrin repeats (many copies) B9-C2 PF07162.11 CDI78363.1 - 1.8e-16 60.8 0.0 1.8e-16 60.8 0.0 1.9 2 1 0 2 2 2 1 Ciliary basal body-associated, B9 protein SPX PF03105.19 CDI78363.1 - 5.9e-06 26.4 10.9 7.1e-06 26.2 10.9 1.0 1 0 0 1 1 1 1 SPX domain Pex14_N PF04695.13 CDI78363.1 - 0.0083 16.8 6.0 0.0083 16.8 6.0 2.2 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2722 PF10846.8 CDI78363.1 - 0.0094 14.9 12.2 0.0094 14.9 12.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) 5-FTHF_cyc-lig PF01812.20 CDI78363.1 - 0.031 14.1 0.7 0.048 13.5 0.7 1.2 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family TFIIA PF03153.13 CDI78363.1 - 0.096 12.7 23.3 0.2 11.6 18.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI78363.1 - 0.69 9.4 16.8 1.6 8.2 6.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 CDI78363.1 - 1.1 8.1 18.5 0.18 10.7 10.4 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI78363.1 - 1.6 7.4 19.5 0.35 9.6 2.7 2.0 2 0 0 2 2 2 0 Presenilin DUF908 PF06012.12 CDI78363.1 - 4 6.8 19.0 0.33 10.3 5.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Kei1 PF08552.11 CDI78363.1 - 4.6 7.1 9.9 4.6 7.1 0.9 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF913 PF06025.12 CDI78363.1 - 4.6 6.1 10.8 1.3 7.9 1.0 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 CDI78363.1 - 5.8 6.6 7.0 1.9 8.2 0.8 2.1 2 0 0 2 2 2 0 Connexin MID_MedPIWI PF18296.1 CDI78363.1 - 9.1 6.0 19.2 1.3 8.7 5.5 2.2 2 0 0 2 2 2 0 MID domain of medPIWI AP2 PF00847.20 CDI78364.1 - 1.9e-20 72.8 1.2 1.1e-09 38.4 0.0 3.8 2 0 0 2 2 2 2 AP2 domain NAM-associated PF14303.6 CDI78365.1 - 0.0065 17.2 0.0 0.0065 17.2 0.0 4.4 3 1 2 5 5 5 1 No apical meristem-associated C-terminal domain Robl_LC7 PF03259.17 CDI78365.1 - 0.3 10.9 0.0 0.3 10.9 0.0 2.2 1 1 1 2 2 2 0 Roadblock/LC7 domain Apt1 PF10351.9 CDI78365.1 - 1.3 7.8 42.3 0.17 10.7 23.8 2.5 2 0 0 2 2 2 0 Golgi-body localisation protein domain Spt20 PF12090.8 CDI78366.1 - 0.042 13.5 8.7 0.049 13.2 8.7 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI78366.1 - 1 9.3 19.4 1.3 8.9 19.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TFIIA PF03153.13 CDI78367.1 - 6e-06 26.5 66.3 0.00015 21.9 36.7 2.8 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit tRNA-synt_2b PF00587.25 CDI78367.1 - 0.02 14.9 0.0 0.57 10.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 CDI78367.1 - 0.056 12.9 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Sin_N PF04801.13 CDI78367.1 - 0.071 12.3 29.0 0.0096 15.2 19.7 2.5 2 0 0 2 2 2 0 Sin-like protein conserved region CNDH2_C PF16858.5 CDI78367.1 - 0.57 10.0 19.2 0.62 9.9 13.1 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF1980 PF09323.10 CDI78367.1 - 2.1 8.2 10.1 2.2 8.1 6.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Peptidase_S64 PF08192.11 CDI78367.1 - 5 5.5 25.9 0.59 8.5 20.4 2.1 2 0 0 2 2 2 0 Peptidase family S64 DUF2370 PF10176.9 CDI78367.1 - 5.5 6.6 8.5 0.52 9.9 3.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) PAT1 PF09770.9 CDI78367.1 - 8.4 4.5 44.8 0.011 14.0 25.6 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Adaptin_N PF01602.20 CDI78368.1 - 3.6e-15 55.5 0.0 4.3e-15 55.3 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 CDI78368.1 - 0.13 12.7 0.1 0.65 10.4 0.1 2.1 2 1 1 3 3 3 0 HEAT repeats Cse1 PF08506.10 CDI78369.1 - 6.1e-37 127.3 7.7 1.9e-17 63.2 0.0 4.3 3 1 0 4 4 4 3 Cse1 CAS_CSE1 PF03378.15 CDI78369.1 - 1.5e-30 106.1 3.4 1.5e-30 106.1 3.4 3.0 2 2 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 CDI78369.1 - 2.9e-09 36.7 0.4 2.9e-09 36.7 0.4 4.9 7 0 0 7 7 7 1 Importin-beta N-terminal domain DUF3769 PF12600.8 CDI78370.1 - 0.042 12.7 0.3 0.066 12.1 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3769) TFIIA PF03153.13 CDI78370.1 - 3.8 7.4 54.9 2.2 8.2 39.9 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SRP_TPR_like PF17004.5 CDI78371.1 - 0.0008 19.4 1.9 0.0012 18.9 0.3 2.2 2 1 0 2 2 2 1 Putative TPR-like repeat SUIM_assoc PF16619.5 CDI78371.1 - 0.017 15.2 2.0 0.017 15.2 2.0 5.5 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 ACP_syn_III_C PF08541.10 CDI78371.1 - 0.049 13.8 0.5 11 6.3 0.1 2.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DUF3997 PF13162.6 CDI78371.1 - 0.21 11.9 5.3 0.14 12.5 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3997) TPR_14 PF13428.6 CDI78371.1 - 8.6 7.5 36.3 8.1 7.6 4.3 6.5 5 1 1 6 6 6 0 Tetratricopeptide repeat Spore_coat_CotO PF14153.6 CDI78376.1 - 1.9 8.4 9.3 2.2 8.2 9.3 1.0 1 0 0 1 1 1 0 Spore coat protein CotO TPR_7 PF13176.6 CDI78377.1 - 0.015 15.3 9.7 8.8 6.6 0.1 6.4 5 1 0 5 5 5 0 Tetratricopeptide repeat SPX PF03105.19 CDI78377.1 - 0.036 14.0 7.8 0.07 13.0 7.8 1.6 1 0 0 1 1 1 0 SPX domain TPR_1 PF00515.28 CDI78377.1 - 0.036 13.9 12.5 5.7 6.9 0.9 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI78377.1 - 0.059 13.6 13.1 0.67 10.3 0.4 7.0 6 3 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI78377.1 - 0.1 12.3 10.3 8.2 6.2 0.2 5.3 5 1 1 6 6 6 0 TPR repeat DUF572 PF04502.13 CDI78377.1 - 2.5 7.6 8.4 0.52 9.9 4.9 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF572) zf-C4pol PF14260.6 CDI78377.1 - 9.8 6.7 6.8 3.3 8.2 0.6 2.7 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta CRPV_capsid PF08762.10 CDI78378.1 - 0.0015 18.2 0.4 0.0041 16.8 0.4 1.7 1 0 0 1 1 1 1 CRPV capsid protein like RNA_capsid PF03035.14 CDI78378.1 - 1.8 8.5 4.4 0.34 10.9 0.7 1.6 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein PTPS PF01242.19 CDI78379.1 - 8.2e-16 58.1 1.9 6.4e-14 52.0 1.9 2.5 1 1 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase GAGA_bind PF06217.12 CDI78379.1 - 0.0027 18.0 8.0 0.0027 18.0 8.0 3.1 2 1 0 2 2 2 1 GAGA binding protein-like family NPR3 PF03666.13 CDI78379.1 - 0.0046 15.8 15.0 0.0046 15.8 15.0 3.1 3 0 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF4746 PF15928.5 CDI78379.1 - 0.0074 15.8 11.3 0.0074 15.8 11.3 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4746) Afi1 PF07792.12 CDI78379.1 - 0.01 16.3 14.0 0.01 16.3 14.0 3.4 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking AAA_11 PF13086.6 CDI78379.1 - 0.011 15.5 14.2 0.011 15.5 14.2 3.1 2 1 0 2 2 2 0 AAA domain Lin-8 PF03353.15 CDI78379.1 - 0.8 9.2 62.1 0.025 14.1 24.0 3.2 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist zf-RING_2 PF13639.6 CDI78380.1 - 6e-10 39.3 11.6 6e-10 39.3 11.6 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 CDI78380.1 - 1.3e-06 28.6 15.1 6.2e-06 26.4 15.1 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDI78380.1 - 2.7e-05 24.1 3.1 6.1e-05 23.0 3.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CDI78380.1 - 3.5e-05 23.5 10.8 3.5e-05 23.5 10.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDI78380.1 - 0.00013 22.1 4.8 0.00032 20.8 4.8 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain RskA PF10099.9 CDI78380.1 - 0.00016 22.1 6.1 0.00016 22.1 6.1 5.1 2 1 2 4 4 2 1 Anti-sigma-K factor rskA zinc_ribbon_9 PF14369.6 CDI78380.1 - 0.00026 21.2 0.2 0.00026 21.2 0.2 3.3 3 1 0 3 3 2 1 zinc-ribbon zf-RING_UBOX PF13445.6 CDI78380.1 - 0.0017 18.3 8.7 0.0017 18.3 8.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDI78380.1 - 0.0049 16.7 11.2 0.0049 16.7 11.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDI78380.1 - 0.0055 16.4 13.0 0.01 15.6 13.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger 60KD_IMP PF02096.20 CDI78380.1 - 0.16 11.9 0.1 0.16 11.9 0.1 1.9 2 0 0 2 2 1 0 60Kd inner membrane protein TF_Zn_Ribbon PF08271.12 CDI78380.1 - 0.57 9.7 3.9 0.21 11.1 0.2 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding zf-C3HC4_3 PF13920.6 CDI78380.1 - 1.6 8.6 13.9 0.16 11.8 7.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI78380.1 - 2.8 8.0 16.7 0.5 10.4 9.8 2.5 2 0 0 2 2 2 0 zinc-RING finger domain DZR PF12773.7 CDI78380.1 - 7.8 6.6 10.9 19 5.4 0.3 3.3 2 1 1 3 3 3 0 Double zinc ribbon TTL PF03133.15 CDI78381.1 - 2e-26 92.8 0.0 2e-26 92.8 0.0 5.0 6 1 0 6 6 6 2 Tubulin-tyrosine ligase family Myb_DNA-binding PF00249.31 CDI78382.1 - 6.7e-08 32.6 0.0 1.5e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SR-25 PF10500.9 CDI78382.1 - 0.00013 21.7 6.8 0.00013 21.7 6.8 11.0 10 2 1 11 11 11 2 Nuclear RNA-splicing-associated protein Activator_LAG-3 PF11498.8 CDI78382.1 - 0.001 18.2 5.1 0.001 18.2 5.1 7.2 4 2 2 6 6 6 1 Transcriptional activator LAG-3 AP2 PF00847.20 CDI78382.1 - 6.6 7.1 8.3 2.3 8.5 0.0 4.7 3 0 0 3 3 3 0 AP2 domain UBA PF00627.31 CDI78383.1 - 7.1e-10 38.6 0.8 2.6e-09 36.8 0.8 2.1 1 0 0 1 1 1 1 UBA/TS-N domain Peptidase_C97 PF05903.14 CDI78383.1 - 1.3e-06 28.3 0.0 0.032 14.0 0.0 2.4 1 1 1 2 2 2 2 PPPDE putative peptidase domain PUB PF09409.10 CDI78383.1 - 1.2e-05 25.2 0.0 8.9e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 PUB domain Get5_bdg PF16843.5 CDI78383.1 - 0.022 14.2 0.3 12 5.5 0.5 2.7 3 0 0 3 3 3 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein MG2 PF01835.19 CDI78383.1 - 0.11 12.9 0.5 0.11 12.9 0.5 2.8 4 0 0 4 4 4 0 MG2 domain Mannitol_dh_C PF08125.13 CDI78383.1 - 0.44 10.0 4.4 0.54 9.7 0.6 2.2 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain Aldedh PF00171.22 CDI78384.1 - 3.9e-113 378.4 0.5 3.8e-112 375.1 0.0 3.0 2 1 0 2 2 2 1 Aldehyde dehydrogenase family DNA_methylase PF00145.17 CDI78385.1 - 2.3e-21 76.5 12.5 1e-10 41.5 0.0 4.4 4 1 0 4 4 4 4 C-5 cytosine-specific DNA methylase SUIM_assoc PF16619.5 CDI78385.1 - 0.55 10.3 57.8 0.27 11.3 5.3 4.7 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF4710 PF15828.5 CDI78385.1 - 9.9 6.4 12.5 2.4 8.3 0.2 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4710) PHD PF00628.29 CDI78386.1 - 1.2e-11 44.4 4.2 1.2e-11 44.4 4.2 2.9 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 CDI78386.1 - 5.5e-07 29.8 11.9 5.5e-07 29.8 11.9 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDI78386.1 - 2.1e-05 24.3 8.6 2.1e-05 24.3 8.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI78386.1 - 0.00056 19.7 11.7 0.00056 19.7 11.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDI78386.1 - 0.00079 19.7 12.5 0.0073 16.6 7.0 3.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain PHD_2 PF13831.6 CDI78386.1 - 0.00099 18.6 1.1 0.0024 17.4 1.1 1.7 1 0 0 1 1 1 1 PHD-finger Prok-RING_4 PF14447.6 CDI78386.1 - 0.0019 18.0 10.0 0.0019 18.0 10.0 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CDI78386.1 - 0.0048 16.7 11.5 0.0048 16.7 11.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI78386.1 - 0.0083 16.1 9.6 0.0083 16.1 9.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Baculo_IE-1 PF05290.11 CDI78386.1 - 0.0092 15.9 3.3 0.025 14.5 3.3 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) SR-25 PF10500.9 CDI78387.1 - 0.0019 17.8 52.5 0.0019 17.8 52.5 3.5 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein Spore_GerAC PF05504.11 CDI78387.1 - 0.039 14.2 4.1 0.059 13.6 4.1 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Utp14 PF04615.13 CDI78387.1 - 0.17 10.4 37.2 0.21 10.1 37.2 1.1 1 0 0 1 1 1 0 Utp14 protein TFIIA PF03153.13 CDI78387.1 - 1.5 8.7 25.9 1.9 8.4 25.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_S8 PF00082.22 CDI78388.1 - 9.8e-13 48.0 12.2 9.8e-13 48.0 12.2 2.4 1 1 1 2 2 2 1 Subtilase family PolyA_pol PF01743.20 CDI78389.1 - 1.3e-08 35.3 0.0 5.3e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Poly A polymerase head domain Spt20 PF12090.8 CDI78389.1 - 1 8.9 19.5 0.24 11.0 2.8 2.6 3 0 0 3 3 3 0 Spt20 family MSA-2c PF12238.8 CDI78389.1 - 9.1 6.2 8.5 22 5.0 3.2 2.4 2 0 0 2 2 2 0 Merozoite surface antigen 2c Cpn60_TCP1 PF00118.24 CDI78392.1 - 9.3e-144 479.7 11.3 1.7e-143 478.8 11.3 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_60s PF00428.19 CDI78392.1 - 7.3 7.3 21.4 0.18 12.4 7.1 3.1 3 0 0 3 3 3 0 60s Acidic ribosomal protein UNC-50 PF05216.13 CDI78393.1 - 1.9e-21 76.7 0.0 2.6e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 UNC-50 family PIG-F PF06699.11 CDI78393.1 - 0.0067 16.6 1.4 0.011 15.9 1.4 1.3 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Mannitol_dh_C PF08125.13 CDI78394.1 - 4.2e-59 200.0 0.0 8.4e-59 199.0 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 CDI78394.1 - 5.2e-23 81.9 0.0 4.7e-22 78.8 0.0 2.3 1 1 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Ribosomal_60s PF00428.19 CDI78394.1 - 0.098 13.3 0.2 0.098 13.3 0.2 4.3 3 1 0 4 4 4 0 60s Acidic ribosomal protein KH_1 PF00013.29 CDI78395.1 - 8.4e-39 131.2 0.8 2.3e-09 37.0 0.1 6.2 5 1 0 5 5 5 4 KH domain KH_2 PF07650.17 CDI78395.1 - 5.5e-08 32.5 0.4 0.9 9.4 0.0 4.3 4 0 0 4 4 4 3 KH domain KH_5 PF13184.6 CDI78395.1 - 3.1e-05 24.0 0.4 0.29 11.2 0.0 3.6 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 CDI78395.1 - 0.16 12.0 0.0 2.2 8.3 0.0 2.7 4 0 0 4 4 4 0 KH-like RNA-binding domain Noc2 PF03715.13 CDI78396.1 - 4.7e-23 81.9 0.1 4.7e-23 81.9 0.1 1.9 2 0 0 2 2 2 1 Noc2p family SUIM_assoc PF16619.5 CDI78396.1 - 0.017 15.1 1.2 0.017 15.1 1.2 8.6 7 2 0 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 DUF4829 PF16111.5 CDI78396.1 - 9.5 7.0 11.1 2.1 9.1 7.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4829) RskA PF10099.9 CDI78397.1 - 4.6e-05 23.8 1.5 4.6e-05 23.8 1.5 19.6 2 2 8 12 12 12 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI78397.1 - 0.0016 18.1 7.2 0.0016 18.1 7.2 14.6 10 3 3 14 14 14 3 Nuclear RNA-splicing-associated protein CNOT1_CAF1_bind PF16415.5 CDI78400.1 - 5.3e-65 218.9 3.1 4e-50 170.3 0.2 2.5 2 0 0 2 2 2 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 CDI78400.1 - 4.3e-50 169.4 1.8 4.3e-50 169.4 1.8 5.4 7 0 0 7 7 7 1 Domain of unknown function (DUF3819) Not1 PF04054.15 CDI78400.1 - 1.2e-23 83.7 6.6 2.2e-20 72.9 0.6 3.9 3 0 0 3 3 3 2 CCR4-Not complex component, Not1 CNOT1_TTP_bind PF16417.5 CDI78400.1 - 4.4e-08 32.5 0.0 4.4e-08 32.5 0.0 7.8 8 1 0 8 8 8 1 CCR4-NOT transcription complex subunit 1 TTP binding domain Spt20 PF12090.8 CDI78400.1 - 0.0016 18.1 10.8 0.0016 18.1 10.8 9.6 8 2 0 8 8 8 2 Spt20 family Pex14_N PF04695.13 CDI78400.1 - 0.0053 17.4 11.3 0.0053 17.4 11.3 13.2 12 2 0 12 12 12 3 Peroxisomal membrane anchor protein (Pex14p) conserved region Arv1 PF04161.13 CDI78401.1 - 2.1e-36 126.1 6.1 4.2e-32 112.0 0.1 3.3 3 1 0 3 3 3 2 Arv1-like family BatD PF13584.6 CDI78401.1 - 0.00097 18.1 1.8 0.00097 18.1 1.8 2.6 3 0 0 3 3 3 1 Oxygen tolerance DUF4228 PF14009.6 CDI78401.1 - 0.0048 17.3 2.0 0.0048 17.3 2.0 3.6 2 2 1 3 3 3 1 Domain of unknown function (DUF4228) DUF2681 PF10883.8 CDI78401.1 - 0.0085 16.5 0.1 0.0085 16.5 0.1 5.2 6 0 0 6 6 6 1 Protein of unknown function (DUF2681) Nudix_N_2 PF14803.6 CDI78401.1 - 0.02 14.8 5.1 0.054 13.4 3.8 2.4 1 1 1 2 2 2 0 Nudix N-terminal Suf PF05843.14 CDI78401.1 - 0.054 13.5 15.7 1.1 9.1 4.1 3.1 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) RskA PF10099.9 CDI78401.1 - 0.075 13.3 0.1 0.075 13.3 0.1 6.2 2 1 2 5 5 5 0 Anti-sigma-K factor rskA TLC PF03219.14 CDI78401.1 - 0.091 11.5 0.3 0.17 10.6 0.3 1.3 1 0 0 1 1 1 0 TLC ATP/ADP transporter BBS2_N PF14781.6 CDI78401.1 - 0.51 10.3 3.9 29 4.6 0.2 3.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal Peroxin-3 PF04882.12 CDI78401.1 - 0.63 9.0 8.7 41 3.0 8.7 2.5 1 1 0 1 1 1 0 Peroxin-3 Sec7_N PF12783.7 CDI78402.1 - 1.4e-10 41.3 6.2 1.4e-10 41.3 6.2 3.1 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal MFS_1_like PF12832.7 CDI78402.1 - 0.16 10.8 0.5 0.63 8.8 0.3 2.1 2 0 0 2 2 2 0 MFS_1 like family CSN8_PSD8_EIF3K PF10075.9 CDI78403.1 - 1.7e-12 47.6 0.0 2.9e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family DUF1645 PF07816.11 CDI78404.1 - 0.0003 21.4 10.6 0.0003 21.4 10.6 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1645) Herpes_capsid PF06112.11 CDI78404.1 - 0.017 15.2 7.1 0.056 13.5 7.1 1.9 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Sdh5 PF03937.16 CDI78404.1 - 0.074 13.0 1.0 0.19 11.7 1.0 1.7 1 0 0 1 1 1 0 Flavinator of succinate dehydrogenase SCAI PF12070.8 CDI78404.1 - 1 8.2 16.7 0.027 13.3 4.0 2.3 2 1 0 2 2 2 0 Protein SCAI SPX PF03105.19 CDI78404.1 - 3.8 7.3 16.6 1.4 8.7 13.8 1.7 2 0 0 2 2 2 0 SPX domain SLC12 PF03522.15 CDI78404.1 - 9.7 5.1 20.7 1.4 7.8 15.9 1.9 2 0 0 2 2 2 0 Solute carrier family 12 PTS_2-RNA PF01885.16 CDI78405.1 - 2.8e-61 206.7 1.1 9.6e-61 205.0 0.0 2.5 2 1 0 2 2 2 1 RNA 2'-phosphotransferase, Tpt1 / KptA family MecA PF05389.12 CDI78405.1 - 0.37 10.4 14.3 4.5 6.8 0.1 3.3 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) Caldesmon PF02029.15 CDI78405.1 - 0.44 9.3 27.8 0.33 9.7 10.2 3.2 3 0 0 3 3 3 0 Caldesmon AAA_23 PF13476.6 CDI78405.1 - 4.8 7.6 33.8 3.1 8.2 10.7 3.4 3 0 0 3 3 3 0 AAA domain PRT_C PF08372.10 CDI78406.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal SUIM_assoc PF16619.5 CDI78407.1 - 0.014 15.5 9.3 0.014 15.5 9.3 10.6 7 2 2 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 Vps26 PF03643.15 CDI78408.1 - 1.6e-66 224.1 0.8 1.9e-66 223.9 0.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Coilin_N PF15862.5 CDI78410.1 - 2.2 8.1 14.1 0.073 12.9 1.9 2.7 1 1 1 2 2 2 0 Coilin N-terminus ASH PF15780.5 CDI78411.1 - 6.1e-09 36.0 0.1 0.0019 18.3 0.0 3.3 3 0 0 3 3 3 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 CDI78411.1 - 1.9e-06 28.1 0.4 8.4e-06 26.0 0.1 2.4 2 1 0 2 2 2 1 Transmembrane protein 131-like PapD-like PF14874.6 CDI78411.1 - 0.007 16.5 0.2 9.4 6.5 0.0 3.8 4 0 0 4 4 4 1 Flagellar-associated PapD-like Motile_Sperm PF00635.26 CDI78411.1 - 0.012 15.5 0.1 0.28 11.1 0.0 2.5 2 0 0 2 2 2 0 MSP (Major sperm protein) domain BCDHK_Adom3 PF10436.9 CDI78413.1 - 0.0052 16.6 0.1 0.014 15.2 0.1 1.8 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase WD40 PF00400.32 CDI78414.1 - 3.9e-16 59.1 14.7 0.012 16.5 0.7 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat SPX PF03105.19 CDI78414.1 - 0.00062 19.8 9.1 0.00083 19.4 9.1 1.1 1 0 0 1 1 1 1 SPX domain Gmad1 PF10647.9 CDI78414.1 - 0.019 14.7 0.7 0.019 14.7 0.7 3.0 3 1 0 4 4 4 0 Lipoprotein LpqB beta-propeller domain Macoilin PF09726.9 CDI78414.1 - 0.028 13.0 11.5 0.043 12.4 11.5 1.3 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI78414.1 - 0.44 9.3 1.3 0.6 8.8 1.3 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI78414.1 - 0.5 9.2 14.3 0.67 8.7 14.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Miga PF10265.9 CDI78414.1 - 1.9 7.4 11.3 2.7 6.8 11.3 1.1 1 0 0 1 1 1 0 Mitoguardin TauE PF01925.19 CDI78415.1 - 6e-06 26.1 8.9 6e-06 26.1 8.9 3.5 3 1 1 4 4 4 1 Sulfite exporter TauE/SafE SPX PF03105.19 CDI78416.1 - 0.0029 17.6 1.1 0.0029 17.6 1.1 4.7 2 1 0 2 2 2 1 SPX domain Neur_chan_memb PF02932.16 CDI78417.1 - 1.5 8.9 5.4 1.4 8.9 5.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region E3_UFM1_ligase PF09743.9 CDI78418.1 - 1e-19 71.3 0.0 1e-19 71.3 0.0 2.7 3 1 1 4 4 4 1 E3 UFM1-protein ligase 1 VWA_2 PF13519.6 CDI78418.1 - 0.0027 18.3 0.1 0.0027 18.3 0.1 3.3 3 0 0 3 3 3 1 von Willebrand factor type A domain RR_TM4-6 PF06459.12 CDI78418.1 - 2.1 8.1 10.5 5 6.9 10.5 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI78418.1 - 2.2 6.3 5.4 3.3 5.7 5.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 CDI78418.1 - 3.3 6.8 8.8 9.9 5.3 7.4 1.8 1 1 0 2 2 2 0 ZIP Zinc transporter DUF2722 PF10846.8 CDI78419.1 - 0.00094 18.2 20.9 0.00094 18.2 20.9 4.1 2 2 0 2 2 1 1 Protein of unknown function (DUF2722) Lin-8 PF03353.15 CDI78419.1 - 0.0013 18.3 5.1 0.0013 18.3 5.1 2.3 2 0 0 2 2 2 1 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDI78419.1 - 0.003 17.6 61.3 0.16 12.0 22.9 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI78419.1 - 0.0042 15.9 4.6 0.0042 15.9 4.6 2.4 2 0 0 2 2 2 1 Presenilin GNAT_acetyltr_2 PF13718.6 CDI78419.1 - 0.017 14.5 1.0 0.017 14.5 1.0 2.5 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Otopetrin PF03189.13 CDI78419.1 - 0.019 13.8 0.0 0.057 12.2 0.0 1.8 1 1 0 1 1 1 0 Otopetrin SUIM_assoc PF16619.5 CDI78419.1 - 0.079 13.0 0.0 0.079 13.0 0.0 7.1 2 2 1 4 4 1 0 Unstructured region C-term to UIM in Ataxin3 Sin_N PF04801.13 CDI78419.1 - 0.092 11.9 37.7 0.083 12.1 8.9 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region Usp PF00582.26 CDI78419.1 - 0.11 13.0 0.4 0.11 13.0 0.4 3.7 3 1 0 3 3 2 0 Universal stress protein family FAM60A PF15396.6 CDI78419.1 - 0.29 11.1 13.0 0.098 12.6 0.3 2.6 2 0 0 2 2 2 0 Protein Family FAM60A DUF3402 PF11882.8 CDI78419.1 - 0.5 9.4 16.1 0.12 11.4 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) PAT1 PF09770.9 CDI78419.1 - 0.51 8.5 41.4 0.066 11.5 16.9 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TRM13 PF05206.14 CDI78419.1 - 1.1 8.7 10.5 1 8.8 2.4 2.4 2 0 0 2 2 2 0 Methyltransferase TRM13 Connexin PF00029.19 CDI78419.1 - 1.2 8.9 14.4 0.18 11.5 2.6 2.3 2 0 0 2 2 2 0 Connexin RIFIN PF02009.16 CDI78419.1 - 2 8.3 17.1 0.086 12.7 4.0 2.3 2 0 0 2 2 2 0 Rifin LAP1C PF05609.12 CDI78419.1 - 2 7.4 25.4 0.038 13.1 5.6 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Scs3p PF10261.9 CDI78419.1 - 2.5 7.6 10.0 0.067 12.7 1.3 2.2 2 0 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF89 PF01937.19 CDI78419.1 - 2.6 6.9 6.7 0.22 10.5 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF89 FHIPEP PF00771.20 CDI78419.1 - 3 6.2 11.5 0.48 8.8 1.7 2.3 2 0 0 2 2 2 0 FHIPEP family SID-1_RNA_chan PF13965.6 CDI78419.1 - 3.8 5.8 10.7 0.23 9.8 1.0 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 EOS1 PF12326.8 CDI78419.1 - 5 7.0 9.6 0.79 9.6 1.3 2.7 2 1 0 2 2 2 0 N-glycosylation protein Methyltransf_5 PF01795.19 CDI78420.1 - 5e-41 141.2 0.2 2.8e-20 73.1 1.4 3.7 3 1 0 3 3 3 3 MraW methylase family SUIM_assoc PF16619.5 CDI78420.1 - 0.034 14.2 19.1 0.28 11.3 4.1 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 NPR3 PF03666.13 CDI78420.1 - 0.039 12.8 0.4 0.059 12.2 0.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Herpes_U59 PF04529.12 CDI78420.1 - 0.039 13.0 0.2 0.059 12.4 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus U59 protein DndB PF14072.6 CDI78420.1 - 0.15 11.3 0.4 0.21 10.7 0.4 1.1 1 0 0 1 1 1 0 DNA-sulfur modification-associated TFIIA PF03153.13 CDI78420.1 - 0.48 10.4 14.4 2 8.3 3.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI78420.1 - 3.7 7.1 12.9 4 7.0 0.5 2.2 2 0 0 2 2 2 0 Spt20 family WD40 PF00400.32 CDI78421.1 - 0.0032 18.3 0.0 0.009 16.8 0.0 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat RMI1_N PF08585.12 CDI78422.1 - 2.7e-15 56.7 1.4 1.1e-12 48.2 0.6 2.8 2 1 0 2 2 2 1 RecQ mediated genome instability protein SR-25 PF10500.9 CDI78422.1 - 8.1 6.0 13.2 21 4.6 13.2 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMS PF00817.20 CDI78423.1 - 1.2e-11 44.8 0.0 7e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 impB/mucB/samB family IMS_C PF11799.8 CDI78423.1 - 6.6e-05 23.6 0.0 0.00012 22.8 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Spt20 PF12090.8 CDI78423.1 - 3.1 7.4 12.1 5.2 6.6 12.1 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI78423.1 - 8.1 6.3 12.4 2.8 7.9 9.4 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Caldesmon PF02029.15 CDI78424.1 - 3.8e-08 32.5 15.9 3.8e-08 32.5 15.9 5.9 5 1 0 5 5 5 1 Caldesmon Spem1 PF15670.5 CDI78425.1 - 0.11 12.0 11.6 0.2 11.2 11.6 1.4 1 0 0 1 1 1 0 Spermatid maturation protein 1 DUF2956 PF11169.8 CDI78425.1 - 0.37 11.0 14.6 0.32 11.2 9.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) PGA2 PF07543.12 CDI78425.1 - 0.39 10.7 11.2 0.15 12.1 0.7 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 FoP_duplication PF13865.6 CDI78425.1 - 1.1 9.8 13.4 0.3 11.7 9.4 2.0 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 NAM-associated PF14303.6 CDI78425.1 - 2.5 8.8 25.5 0.51 11.0 10.5 2.1 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain RSRP PF17069.5 CDI78425.1 - 3.9 6.9 35.8 0.17 11.4 30.0 1.6 2 0 0 2 2 2 0 Arginine/Serine-Rich protein 1 Codanin-1_C PF15296.6 CDI78425.1 - 5.7 7.0 14.9 0.9 9.6 9.6 2.1 2 0 0 2 2 2 0 Codanin-1 C-terminus Eapp_C PF10238.9 CDI78425.1 - 7.5 6.6 11.6 4.3 7.4 6.2 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein CCDC106 PF15794.5 CDI78425.1 - 7.6 6.2 20.8 0.78 9.4 13.6 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 PPP4R2 PF09184.11 CDI78425.1 - 9.4 5.7 17.4 0.6 9.7 12.0 1.7 1 1 1 2 2 2 0 PPP4R2 TTL PF03133.15 CDI78426.1 - 7.9e-31 107.3 1.3 6e-17 61.7 1.2 8.5 9 1 1 10 10 10 3 Tubulin-tyrosine ligase family RskA PF10099.9 CDI78426.1 - 0.0036 17.6 0.8 0.0036 17.6 0.8 30.7 12 8 10 25 25 25 6 Anti-sigma-K factor rskA NLE PF08154.12 CDI78427.1 - 2.8e-17 63.0 0.2 4.9e-17 62.2 0.2 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 CDI78427.1 - 5.2e-15 55.6 9.3 0.031 15.2 0.2 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78427.1 - 0.00011 22.4 0.1 2.3 8.6 0.0 4.1 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDI78427.1 - 0.00044 19.0 0.0 0.16 10.6 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Pkinase PF00069.25 CDI78431.1 - 1.8e-14 53.8 0.0 1.5e-10 40.9 0.0 4.1 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78431.1 - 0.0098 15.2 0.0 0.44 9.8 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase RAB3GAP2_N PF14655.6 CDI78431.1 - 0.63 9.2 5.4 0.15 11.3 0.1 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus SUIM_assoc PF16619.5 CDI78431.1 - 9.1 6.4 42.9 2.8 8.0 8.0 5.7 6 0 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 zf-C2HC_2 PF13913.6 CDI78432.1 - 3.4e-10 39.6 10.6 1.8e-05 24.5 0.2 3.5 3 0 0 3 3 3 3 zinc-finger of a C2HC-type zf-ACC PF17848.1 CDI78432.1 - 0.0062 16.6 6.3 0.021 14.9 0.5 2.8 3 0 0 3 3 3 1 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 CDI78432.1 - 0.008 15.8 1.3 3.8 7.2 0.2 3.2 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger PyrI_C PF02748.15 CDI78432.1 - 0.014 15.2 1.0 0.23 11.4 0.6 2.4 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf_C2HC_14 PF18574.1 CDI78432.1 - 0.069 13.0 0.3 0.069 13.0 0.3 1.8 2 0 0 2 2 1 0 C2HC Zing finger domain Sgf11 PF08209.11 CDI78432.1 - 0.078 12.6 8.2 0.11 12.1 1.2 3.1 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-C2H2_4 PF13894.6 CDI78432.1 - 0.085 13.7 8.7 7.6 7.7 0.6 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger DUF2318 PF10080.9 CDI78432.1 - 0.13 12.4 4.6 6.2 7.0 0.0 3.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2318) PRP21_like_P PF12230.8 CDI78432.1 - 0.19 11.6 0.4 0.4 10.5 0.3 1.6 1 1 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein FAM76 PF16046.5 CDI78432.1 - 0.4 10.0 10.9 0.88 8.9 4.6 2.1 2 0 0 2 2 2 0 FAM76 protein Nudix_N_2 PF14803.6 CDI78432.1 - 0.58 10.1 5.3 23 5.0 0.1 3.6 3 0 0 3 3 3 0 Nudix N-terminal zf-TRAF_2 PF15965.5 CDI78432.1 - 0.73 10.3 6.4 1.1 9.8 2.7 2.2 2 0 0 2 2 2 0 TRAF-like zinc-finger zf-MYND PF01753.18 CDI78432.1 - 1.6 8.9 7.8 1.7 8.8 2.8 2.7 2 1 0 2 2 2 0 MYND finger zinc-ribbons_6 PF07191.12 CDI78432.1 - 2.2 8.3 6.7 2.6 8.1 3.7 2.2 2 0 0 2 2 2 0 zinc-ribbons DUF4524 PF15025.6 CDI78432.1 - 3.3 7.4 4.8 3.8 7.2 0.2 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4524) OrfB_Zn_ribbon PF07282.11 CDI78432.1 - 3.3 7.7 5.8 12 5.9 0.3 3.2 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 CDI78432.1 - 7.7 6.7 11.5 8.9 6.5 0.5 3.4 2 1 1 3 3 3 0 Zinc ribbon domain Dehydrin PF00257.19 CDI78432.1 - 9 6.8 6.7 5.5 7.5 0.2 2.2 2 0 0 2 2 2 0 Dehydrin Adaptin_N PF01602.20 CDI78433.1 - 1.6e-72 244.8 6.7 2.2e-67 227.8 3.5 2.0 2 0 0 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 CDI78433.1 - 5.8e-13 49.1 0.0 5.8e-13 49.1 0.0 2.4 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 CDI78433.1 - 0.0008 19.5 0.2 0.19 11.8 0.1 3.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDI78433.1 - 0.0055 17.1 19.0 0.07 13.5 0.5 5.4 4 2 1 5 5 5 2 HEAT repeats FANCI_S2 PF14676.6 CDI78433.1 - 0.72 10.1 3.9 0.95 9.8 0.6 2.5 2 0 0 2 2 2 0 FANCI solenoid 2 HEAT PF02985.22 CDI78433.1 - 4.6 7.8 10.3 8.5 6.9 0.2 5.8 6 0 0 6 6 6 0 HEAT repeat DIM1 PF02966.16 CDI78434.1 - 2.2e-66 221.7 0.5 2.4e-66 221.5 0.5 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CDI78434.1 - 0.0027 17.7 0.1 0.0036 17.3 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin TFIIA PF03153.13 CDI78435.1 - 0.0002 21.5 19.3 0.00023 21.3 19.3 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DNA_photolyase PF00875.18 CDI78435.1 - 0.00032 20.8 0.0 0.00032 20.8 0.0 2.4 2 0 0 2 2 2 1 DNA photolyase Exonuc_VII_L PF02601.15 CDI78435.1 - 0.00083 19.0 10.0 0.0012 18.5 10.0 1.4 1 0 0 1 1 1 1 Exonuclease VII, large subunit SR-25 PF10500.9 CDI78435.1 - 0.0016 18.1 14.5 0.0028 17.3 14.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4746 PF15928.5 CDI78435.1 - 0.025 14.0 7.8 0.04 13.3 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Fmp27_WPPW PF10359.9 CDI78435.1 - 0.12 11.2 14.5 0.17 10.7 14.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain V_ATPase_I PF01496.19 CDI78435.1 - 0.3 8.9 10.7 0.43 8.4 10.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 CDI78435.1 - 0.43 9.1 16.2 0.64 8.6 16.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 CDI78435.1 - 0.53 9.6 15.2 0.98 8.7 15.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCSAP PF15748.5 CDI78435.1 - 0.75 9.9 17.1 1.3 9.2 17.1 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF3552 PF12072.8 CDI78435.1 - 0.93 8.9 32.3 2.2 7.7 32.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) SOBP PF15279.6 CDI78435.1 - 1.8 9.1 13.1 2.7 8.5 13.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein OmpH PF03938.14 CDI78435.1 - 3.1 8.1 46.0 8.6 6.7 46.0 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Neur_chan_memb PF02932.16 CDI78435.1 - 5.2 7.0 8.0 9.6 6.2 8.0 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HemX PF04375.14 CDI78435.1 - 6.2 6.0 38.0 12 5.1 38.0 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TCP PF03634.13 CDI78435.1 - 7.3 7.1 18.0 17 5.9 18.0 1.5 1 0 0 1 1 1 0 TCP family transcription factor HSP70 PF00012.20 CDI78435.1 - 9.7 4.2 12.2 16 3.5 12.2 1.2 1 0 0 1 1 1 0 Hsp70 protein eIF-3c_N PF05470.12 CDI78436.1 - 6.2e-71 239.5 19.3 2.8e-69 234.0 19.3 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Nop14 PF04147.12 CDI78436.1 - 0.73 8.0 37.2 0.013 13.8 29.8 1.7 2 0 0 2 2 2 0 Nop14-like family zf-U1 PF06220.12 CDI78439.1 - 1.7e-17 62.9 1.5 2.3e-17 62.4 1.5 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.7 CDI78439.1 - 5.1 7.6 5.2 66 4.1 5.2 2.2 1 1 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDI78439.1 - 6.1 7.3 5.7 0.62 10.4 1.3 1.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Prefoldin_2 PF01920.20 CDI78441.1 - 1.8e-05 24.7 3.7 4.2e-05 23.4 3.7 1.6 1 1 0 1 1 1 1 Prefoldin subunit Methyltransf_16 PF10294.9 CDI78442.1 - 9.9e-18 64.5 0.2 4.4e-17 62.3 0.2 2.0 1 1 0 1 1 1 1 Lysine methyltransferase Ank_2 PF12796.7 CDI78442.1 - 5.4e-13 49.3 1.6 4.2e-11 43.3 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI78442.1 - 1.3e-11 44.8 1.6 2.9e-10 40.5 0.3 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 CDI78442.1 - 5.3e-11 42.5 0.6 3.7e-06 27.1 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CDI78442.1 - 4.8e-10 38.8 0.9 0.00013 22.1 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CDI78442.1 - 7e-09 35.8 3.2 6.7e-08 32.7 0.3 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Methyltransf_23 PF13489.6 CDI78442.1 - 1.1e-08 35.1 2.2 1.8e-08 34.4 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI78442.1 - 0.0025 18.5 0.2 0.025 15.3 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CDI78442.1 - 0.0032 16.9 0.0 0.0032 16.9 0.0 2.5 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CDI78442.1 - 0.0051 16.6 0.4 0.028 14.2 0.4 2.3 1 1 0 1 1 1 1 Methyltransferase domain SUIM_assoc PF16619.5 CDI78442.1 - 0.013 15.6 25.8 0.38 10.8 2.5 3.7 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 MTS PF05175.14 CDI78442.1 - 0.044 13.3 0.0 0.044 13.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain RAB3GAP2_N PF14655.6 CDI78442.1 - 0.96 8.6 7.3 2.7 7.2 3.0 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus ANAPC_CDC26 PF10471.9 CDI78442.1 - 4.2 8.3 27.4 4.3 8.2 0.8 4.5 4 0 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 DUF3391 PF11871.8 CDI78443.1 - 0.073 13.6 6.0 0.13 12.8 6.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Cellulose_synt PF03552.14 CDI78444.1 - 4.5 5.6 8.3 0.25 9.8 2.8 1.6 2 0 0 2 2 2 0 Cellulose synthase Mito_carr PF00153.27 CDI78445.1 - 1.8e-11 43.8 6.8 7.5e-08 32.2 1.2 4.2 3 2 1 4 4 4 2 Mitochondrial carrier protein Exonuc_VII_L PF02601.15 CDI78445.1 - 1.4e-06 28.1 2.5 2.3e-06 27.4 2.5 1.4 1 0 0 1 1 1 1 Exonuclease VII, large subunit FapA PF03961.13 CDI78445.1 - 0.0031 16.2 5.7 0.0041 15.8 5.7 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A DDE_Tnp_ISAZ013 PF07592.11 CDI78445.1 - 0.22 10.5 10.7 0.33 9.9 10.7 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DUF2130 PF09903.9 CDI78445.1 - 0.33 10.2 13.2 0.53 9.5 13.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) CLN3 PF02487.17 CDI78445.1 - 0.37 9.8 3.7 0.6 9.1 3.7 1.3 1 0 0 1 1 1 0 CLN3 protein HemX PF04375.14 CDI78445.1 - 0.88 8.8 39.3 0.15 11.3 35.4 1.6 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase FAM60A PF15396.6 CDI78445.1 - 2.5 8.0 15.9 0.24 11.4 11.0 1.6 2 0 0 2 2 2 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 CDI78445.1 - 3.2 6.0 4.2 4.3 5.6 4.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Phage_GPO PF05929.11 CDI78445.1 - 8.9 5.8 21.2 16 5.0 21.2 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase IMUP PF15761.5 CDI78445.1 - 9.1 7.0 16.6 9.1 7.0 10.2 2.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein Metallophos PF00149.28 CDI78446.1 - 8.6e-13 49.2 0.3 3.4e-08 34.2 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Mre11_DNA_bind PF04152.14 CDI78446.1 - 1.8e-12 47.9 0.8 1.1e-06 29.0 0.1 3.4 3 0 0 3 3 3 2 Mre11 DNA-binding presumed domain Metallophos_2 PF12850.7 CDI78446.1 - 0.00015 22.0 0.0 0.0016 18.6 0.0 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain SUIM_assoc PF16619.5 CDI78446.1 - 0.43 10.7 26.7 1.5 9.0 0.4 3.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2205 PF10224.9 CDI78447.1 - 0.0017 18.3 1.0 0.004 17.1 1.0 1.6 1 0 0 1 1 1 1 Short coiled-coil protein DUF2459 PF09601.10 CDI78447.1 - 0.18 11.6 0.3 0.33 10.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2459) SlyX PF04102.12 CDI78447.1 - 0.21 12.2 0.8 2.8 8.6 0.0 2.6 2 0 0 2 2 2 0 SlyX VPS11_C PF12451.8 CDI78447.1 - 0.24 11.6 1.1 9.1 6.6 0.1 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal Lebercilin PF15619.6 CDI78447.1 - 1.5 8.4 6.8 0.27 10.9 0.2 2.5 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Tymo_coat PF00983.18 CDI78448.1 - 0.041 13.7 0.1 0.1 12.4 0.1 1.6 1 1 0 1 1 1 0 Tymovirus coat protein WD40 PF00400.32 CDI78449.1 - 0.056 14.3 5.9 1e+02 4.0 0.0 5.7 6 0 0 6 6 6 0 WD domain, G-beta repeat DER1 PF04511.15 CDI78451.1 - 5.3e-44 150.4 14.5 6e-44 150.3 14.5 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 CDI78451.1 - 2.8e-06 27.4 15.3 4.4e-06 26.8 15.3 1.3 1 0 0 1 1 1 1 Rhomboid family Spt5_N PF11942.8 CDI78452.1 - 2.2 9.3 12.8 0.34 11.9 4.6 3.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Peptidase_S64 PF08192.11 CDI78452.1 - 5.3 5.4 14.1 3.4 6.0 1.1 2.6 2 0 0 2 2 2 0 Peptidase family S64 NOA36 PF06524.12 CDI78454.1 - 0.14 11.4 19.9 0.15 11.4 19.9 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CDI78454.1 - 0.26 9.3 29.5 0.27 9.3 29.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 CDI78454.1 - 0.33 10.3 24.5 0.33 10.4 24.5 1.0 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 CDI78454.1 - 0.36 10.2 23.7 0.37 10.1 23.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 CDI78454.1 - 0.4 9.9 16.7 0.44 9.7 16.7 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_polI_A34 PF08208.11 CDI78454.1 - 0.5 10.4 16.4 0.57 10.2 16.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RPN2_C PF18004.1 CDI78454.1 - 0.53 10.2 15.5 0.5 10.3 15.5 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FYDLN_acid PF09538.10 CDI78454.1 - 0.8 10.4 17.0 0.87 10.3 17.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF4820 PF16091.5 CDI78454.1 - 1 8.7 10.7 1 8.6 10.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RNA_pol_Rpc4 PF05132.14 CDI78454.1 - 1 9.8 9.3 1.1 9.7 9.3 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Paf1 PF03985.13 CDI78454.1 - 1.1 8.2 25.3 1.1 8.2 25.3 1.0 1 0 0 1 1 1 0 Paf1 SpoIIP PF07454.11 CDI78454.1 - 1.5 8.2 12.0 1.5 8.2 12.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EIIBC-GUT_N PF03612.14 CDI78454.1 - 1.9 8.2 6.9 1.9 8.2 6.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus BUD22 PF09073.10 CDI78454.1 - 1.9 7.8 20.1 1.8 7.8 20.1 1.0 1 0 0 1 1 1 0 BUD22 Connexin PF00029.19 CDI78454.1 - 2.5 7.8 7.4 2.4 7.9 7.4 1.1 1 0 0 1 1 1 0 Connexin Usp PF00582.26 CDI78454.1 - 2.5 8.6 9.9 2.8 8.4 9.9 1.2 1 0 0 1 1 1 0 Universal stress protein family AIF_C PF14721.6 CDI78454.1 - 2.8 8.3 7.9 2.9 8.3 7.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RNA_pol_3_Rpc31 PF11705.8 CDI78454.1 - 2.8 8.1 27.4 3.1 8.0 27.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CPSF100_C PF13299.6 CDI78454.1 - 3.1 8.0 12.2 3 8.0 12.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sigma70_ner PF04546.13 CDI78454.1 - 3.3 7.6 21.2 3.3 7.5 21.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 CDI78454.1 - 3.6 5.7 27.3 3.7 5.6 27.3 1.0 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 CDI78454.1 - 4.3 7.1 16.5 4.1 7.2 16.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CDI78454.1 - 4.6 5.9 10.0 4.2 6.0 10.0 1.0 1 0 0 1 1 1 0 Presenilin THOC2_N PF16134.5 CDI78454.1 - 4.7 5.7 10.8 4.3 5.8 10.8 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF4746 PF15928.5 CDI78454.1 - 5.4 6.3 22.6 5.8 6.2 22.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.17 CDI78454.1 - 5.7 7.0 6.8 5.5 7.1 6.8 1.0 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 CDI78454.1 - 7.4 4.4 9.9 6.8 4.5 9.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SspB PF04386.13 CDI78454.1 - 7.7 6.4 12.9 7.2 6.5 12.9 1.1 1 0 0 1 1 1 0 Stringent starvation protein B Spore_coat_CotO PF14153.6 CDI78454.1 - 8.8 6.2 19.7 8.4 6.3 19.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO CTU2 PF10288.9 CDI78454.1 - 9.5 6.5 8.7 10 6.4 8.7 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 RAB3GAP2_C PF14656.6 CDI78454.1 - 9.6 4.3 8.8 8.8 4.4 8.8 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Zip PF02535.22 CDI78454.1 - 9.8 5.3 7.4 9.5 5.3 7.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CPW_WPC PF09717.10 CDI78455.1 - 4.3e-08 34.0 0.0 5.5e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 Plasmodium falciparum domain of unknown function (CPW_WPC) cEGF PF12662.7 CDI78455.1 - 0.0025 17.7 0.2 0.0025 17.7 0.2 2.0 2 0 0 2 2 2 1 Complement Clr-like EGF-like FXa_inhibition PF14670.6 CDI78455.1 - 0.11 12.8 1.1 0.11 12.8 1.1 1.8 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Glyoxalase PF00903.25 CDI78456.1 - 2.2e-37 128.1 0.2 1.1e-17 64.4 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDI78456.1 - 4.4e-14 52.7 0.1 5.4e-06 26.6 0.0 3.2 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDI78456.1 - 1e-07 32.7 0.0 0.00043 21.0 0.0 2.7 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CDI78456.1 - 9.2e-06 25.6 0.6 1.7 8.6 0.0 4.2 4 1 1 5 5 5 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CDI78456.1 - 0.00095 19.3 0.0 1.2 9.3 0.0 2.8 1 1 1 2 2 2 2 Glyoxalase-like domain DUF3081 PF11280.8 CDI78456.1 - 0.0029 17.4 0.1 3.8 7.4 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF3081) CppA_N PF14506.6 CDI78456.1 - 0.0058 16.7 0.0 1.4 9.0 0.0 2.3 2 0 0 2 2 2 2 CppA N-terminal DUF5320 PF17253.2 CDI78457.1 - 3.1 8.9 6.6 10 7.2 1.4 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) MMR_HSR1_C PF08438.10 CDI78458.1 - 2.6e-10 40.9 0.0 7.3e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 GTPase of unknown function C-terminal TGS PF02824.21 CDI78458.1 - 8.4e-05 22.6 0.0 0.00063 19.7 0.0 2.2 2 0 0 2 2 2 1 TGS domain RNA_pol_Rpc82 PF05645.13 CDI78459.1 - 0.0049 16.7 0.4 2.2 8.0 0.1 2.6 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 DUF1360 PF07098.11 CDI78459.1 - 0.025 14.5 0.0 0.13 12.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) HTH_9 PF08221.11 CDI78459.1 - 0.16 12.1 1.4 13 6.0 0.0 2.9 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain RRM_1 PF00076.22 CDI78460.1 - 2.5e-39 132.9 0.0 5.6e-21 74.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDI78460.1 - 4.7e-08 32.7 0.0 0.0028 17.3 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI78460.1 - 0.00022 21.3 0.1 0.12 12.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 CDI78460.1 - 0.008 15.8 0.1 4.8 7.0 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease B OB domain Amino_oxidase PF01593.24 CDI78461.1 - 3.4e-25 89.3 20.4 5.1e-09 35.9 0.0 5.5 6 1 1 7 7 7 4 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI78461.1 - 1.9e-06 28.0 5.6 1.9e-06 28.0 5.6 3.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDI78461.1 - 1.7e-05 24.3 1.5 5.1e-05 22.6 1.5 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDI78461.1 - 0.0013 17.5 2.2 0.0013 17.5 2.2 2.7 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox PF00070.27 CDI78461.1 - 0.0016 19.0 2.6 0.0034 17.9 2.6 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDI78461.1 - 0.22 10.7 1.2 0.44 9.7 1.2 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CDI78461.1 - 5.8 6.1 7.1 0.35 10.1 1.3 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HisKA_3 PF07730.13 CDI78462.1 - 0.0091 16.5 0.2 0.1 13.1 0.1 2.5 2 0 0 2 2 2 1 Histidine kinase Gln-synt_C PF00120.24 CDI78462.1 - 0.19 10.7 0.5 0.31 10.0 0.5 1.3 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain Gp_dh_C PF02800.20 CDI78463.1 - 2.5e-67 225.4 0.0 3.2e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDI78463.1 - 2.6e-40 136.8 0.0 5.6e-40 135.8 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CDI78463.1 - 0.036 14.2 0.0 0.098 12.8 0.0 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF1474 PF07342.11 CDI78464.1 - 0.09 13.3 0.1 0.68 10.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) Vps54_N PF10475.9 CDI78464.1 - 0.27 10.5 4.0 0.28 10.4 0.9 2.5 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DUF5446 PF17522.2 CDI78464.1 - 0.92 9.7 4.1 5 7.4 0.1 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5446) FXMRP1_C_core PF12235.8 CDI78465.1 - 0.0049 17.5 9.0 0.0086 16.7 9.0 1.4 1 0 0 1 1 1 1 Fragile X-related 1 protein core C terminal Spt20 PF12090.8 CDI78465.1 - 0.026 14.2 3.2 0.026 14.1 3.2 1.1 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI78465.1 - 0.13 11.4 7.5 0.15 11.2 7.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein SAP130_C PF16014.5 CDI78465.1 - 0.2 10.7 12.8 0.24 10.5 12.8 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus TFIIA PF03153.13 CDI78465.1 - 1.2 9.1 12.3 1.6 8.7 12.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI78465.1 - 1.4 7.6 4.2 1.5 7.5 4.2 1.1 1 0 0 1 1 1 0 Presenilin Herpes_DNAp_acc PF04929.12 CDI78465.1 - 2 7.3 8.3 2.2 7.2 8.3 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Hid1 PF12722.7 CDI78465.1 - 9.7 4.2 5.4 10 4.1 5.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DDHD PF02862.17 CDI78466.1 - 3e-29 102.8 11.8 3e-29 102.8 11.8 4.6 2 2 1 3 3 3 1 DDHD domain Endonuc-BsobI PF09194.10 CDI78467.1 - 0.02 14.1 0.0 0.042 13.0 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease BsobI Bestrophin PF01062.21 CDI78467.1 - 0.27 10.6 2.3 0.93 8.8 2.3 1.9 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel INSIG PF07281.12 CDI78467.1 - 0.45 10.1 2.3 35 4.0 0.9 3.7 3 0 0 3 3 3 0 Insulin-induced protein (INSIG) DUF4259 PF14078.6 CDI78467.1 - 4 8.2 21.5 1 10.1 4.4 4.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4259) Mpp10 PF04006.12 CDI78468.1 - 1.1e-39 136.4 139.1 1e-27 96.9 12.4 4.3 2 1 2 4 4 4 3 Mpp10 protein DNA_primase_lrg PF04104.14 CDI78468.1 - 0.11 11.9 0.1 0.11 11.9 0.1 4.8 5 1 1 6 6 6 0 Eukaryotic and archaeal DNA primase, large subunit CCD48 PF15799.5 CDI78469.1 - 0.012 14.0 6.1 0.016 13.6 6.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 CT47 PF15623.6 CDI78469.1 - 0.038 13.8 9.8 0.049 13.5 9.8 1.2 1 0 0 1 1 1 0 Cancer/testis gene family 47 DUF2052 PF09747.9 CDI78469.1 - 0.082 13.0 0.2 0.12 12.5 0.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CCDC53 PF10152.9 CDI78469.1 - 0.33 11.4 1.4 0.49 10.8 1.4 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF3306 PF11748.8 CDI78469.1 - 0.43 11.5 3.9 0.72 10.7 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF775 PF05603.12 CDI78471.1 - 1.2 8.6 9.7 1.4 8.4 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FUSC PF04632.12 CDI78471.1 - 1.3 7.5 12.7 1.4 7.4 12.7 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Fmp27_WPPW PF10359.9 CDI78471.1 - 4.1 6.2 16.9 4.8 5.9 16.9 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DOR PF14839.6 CDI78471.1 - 9.2 6.1 18.3 10 6.0 18.3 1.0 1 0 0 1 1 1 0 DOR family Spt20 PF12090.8 CDI78472.1 - 0.19 11.3 20.9 0.23 11.1 20.9 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI78472.1 - 0.3 11.0 23.7 0.39 10.7 23.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop53 PF07767.11 CDI78472.1 - 0.52 9.7 18.5 0.62 9.4 18.5 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) eIF_4EBP PF05456.11 CDI78472.1 - 0.64 10.0 4.4 1.2 9.1 4.4 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) FAM199X PF15814.5 CDI78472.1 - 2.7 7.0 9.1 3.2 6.7 9.1 1.1 1 0 0 1 1 1 0 Protein family FAM199X GET2 PF08690.10 CDI78472.1 - 5.8 6.5 12.1 7.1 6.2 12.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4834 PF16118.5 CDI78472.1 - 6.7 7.7 10.2 10 7.1 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CDC45 PF02724.14 CDI78472.1 - 9.9 4.3 12.4 11 4.1 12.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_S9 PF00380.19 CDI78473.1 - 1.6e-18 67.3 0.2 1.9e-18 67.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13e PF01294.18 CDI78474.1 - 4e-75 251.6 9.0 5e-75 251.3 9.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e DSPc PF00782.20 CDI78476.1 - 1.6e-17 63.6 0.1 3.5e-17 62.4 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain SUIM_assoc PF16619.5 CDI78476.1 - 0.15 12.2 16.6 2.7 8.1 8.4 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI78476.1 - 2.1 7.9 14.8 0.88 9.1 2.0 2.5 2 0 0 2 2 2 0 Spt20 family Tautomerase PF01361.21 CDI78477.1 - 0.06 13.3 0.3 0.18 11.7 0.3 1.9 1 0 0 1 1 1 0 Tautomerase enzyme YajC PF02699.15 CDI78477.1 - 0.24 11.3 0.6 0.65 9.9 0.6 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit BTB PF00651.31 CDI78479.1 - 3.8e-08 33.5 0.1 8.5e-08 32.4 0.1 1.6 2 0 0 2 2 2 1 BTB/POZ domain Dus PF01207.17 CDI78480.1 - 2.5e-23 82.7 0.0 8.1e-20 71.1 0.0 3.2 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) DUF2102 PF09875.9 CDI78480.1 - 0.12 12.1 0.4 0.34 10.7 0.1 1.7 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2102) zf-FCS PF06467.14 CDI78481.1 - 0.44 10.5 2.2 0.39 10.7 0.2 2.0 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif RNase_J_C PF17770.1 CDI78481.1 - 1.1 10.4 3.5 2.8 9.1 1.7 2.7 2 1 0 3 3 3 0 Ribonuclease J C-terminal domain Met_10 PF02475.16 CDI78482.1 - 1e-26 93.9 0.0 1.2e-25 90.5 0.0 2.1 1 1 0 1 1 1 1 Met-10+ like-protein DUF4481 PF14800.6 CDI78482.1 - 0.69 9.3 3.9 1.4 8.3 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) DUF2526 PF10735.9 CDI78482.1 - 2.8 8.2 10.5 8.5 6.6 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2526) DUF3040 PF11239.8 CDI78483.1 - 0.0047 17.2 3.0 0.076 13.3 0.5 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3040) Med3 PF11593.8 CDI78483.1 - 0.16 11.1 0.2 0.32 10.1 0.2 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF1180 PF06679.12 CDI78483.1 - 0.24 11.8 1.8 0.49 10.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF5131 PF07505.11 CDI78483.1 - 0.5 9.8 4.0 0.25 10.7 1.3 1.8 2 1 1 3 3 3 0 Protein of unknown function (DUF5131) Snapin_Pallidin PF14712.6 CDI78483.1 - 1.4 9.3 5.3 4.4 7.8 0.1 2.9 3 0 0 3 3 3 0 Snapin/Pallidin IBN_N PF03810.19 CDI78487.1 - 5.6e-10 39.0 0.0 5.3e-09 35.9 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 CDI78487.1 - 1.8e-06 27.0 0.0 9.5e-06 24.7 0.0 2.2 2 0 0 2 2 2 1 Cse1 SUIM_assoc PF16619.5 CDI78487.1 - 0.026 14.6 11.4 0.047 13.8 2.7 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI78487.1 - 0.085 13.5 6.7 2.8 8.6 0.5 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein PatG_D PF18047.1 CDI78487.1 - 0.29 11.6 2.8 0.72 10.3 0.0 2.9 2 2 0 2 2 2 0 PatG Domain Xpo1 PF08389.12 CDI78487.1 - 3.6 7.6 11.8 0.073 13.1 2.0 3.1 3 1 0 3 3 3 0 Exportin 1-like protein Spt20 PF12090.8 CDI78487.1 - 5.1 6.6 12.1 2.8 7.5 7.6 2.3 2 0 0 2 2 2 0 Spt20 family LSM PF01423.22 CDI78488.1 - 2.5e-22 78.3 0.0 2.9e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDI78488.1 - 0.001 19.1 0.0 0.0013 18.8 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 CDI78488.1 - 0.05 13.3 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 Hfq protein RIO1 PF01163.22 CDI78490.1 - 1.9e-50 171.1 0.7 2.9e-24 85.7 0.0 3.0 2 1 0 2 2 2 2 RIO1 family TFIIA PF03153.13 CDI78490.1 - 0.00018 21.6 17.6 0.00018 21.6 17.6 2.6 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI78490.1 - 0.016 15.3 0.6 0.016 15.3 0.6 5.0 4 1 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 NAM-associated PF14303.6 CDI78490.1 - 0.022 15.5 10.4 0.022 15.5 10.4 5.8 5 1 1 6 6 6 0 No apical meristem-associated C-terminal domain DUF4050 PF13259.6 CDI78490.1 - 0.071 13.4 0.4 0.071 13.4 0.4 4.9 3 1 0 3 3 3 0 Protein of unknown function (DUF4050) APH PF01636.23 CDI78490.1 - 0.28 11.1 4.8 0.26 11.2 0.3 2.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF3446 PF11928.8 CDI78490.1 - 0.42 10.9 53.0 0.17 12.2 5.6 4.6 4 0 0 4 4 4 0 Early growth response N-terminal domain DUF2052 PF09747.9 CDI78490.1 - 0.8 9.8 38.1 1.6 8.8 0.9 4.2 4 0 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) SURF6 PF04935.12 CDI78491.1 - 5.2e-09 36.2 65.0 5.2e-09 36.2 65.0 3.5 1 1 2 3 3 3 1 Surfeit locus protein 6 TerD PF02342.18 CDI78492.1 - 1.9e-06 27.5 0.0 5.2e-06 26.1 0.0 1.8 1 1 0 1 1 1 1 TerD domain DEAD PF00270.29 CDI78494.1 - 1.4e-32 112.9 0.0 2.4e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI78494.1 - 2e-27 95.7 0.1 3.4e-26 91.8 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI78494.1 - 0.043 13.8 0.0 0.29 11.1 0.0 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Proteasome PF00227.26 CDI78495.1 - 3.8e-59 199.4 0.0 5.2e-59 198.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDI78495.1 - 1.6e-09 37.2 0.0 1.6e-09 37.2 0.0 2.4 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature RskA PF10099.9 CDI78498.1 - 0.00069 20.0 3.8 0.0045 17.3 0.3 33.6 11 9 11 26 26 26 7 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI78498.1 - 0.0036 16.3 0.6 0.0036 16.3 0.6 25.6 22 5 0 24 24 24 6 Protein of unknown function (DUF2722) Cytochrom_B_N_2 PF13631.6 CDI78498.1 - 0.93 9.5 2.7 9.3 6.2 0.1 3.6 3 0 0 3 3 3 0 Cytochrome b(N-terminal)/b6/petB zf-CW PF07496.15 CDI78499.1 - 4.7e-38 129.0 38.3 6.3e-13 48.5 5.2 3.6 3 0 0 3 3 3 3 CW-type Zinc Finger Amino_oxidase PF01593.24 CDI78499.1 - 9.6e-36 124.0 6.2 1.6e-19 70.5 0.5 3.7 3 1 1 4 4 4 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI78499.1 - 6e-05 23.2 3.6 6e-05 23.2 3.6 3.0 3 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDI78499.1 - 0.0016 17.7 0.1 0.0043 16.3 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDI78499.1 - 0.021 14.1 0.4 0.08 12.2 0.3 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 CDI78499.1 - 0.046 14.3 0.3 0.12 13.0 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI78499.1 - 0.073 12.3 1.0 0.14 11.4 1.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDI78499.1 - 0.25 10.0 9.8 0.056 12.1 0.2 2.8 2 0 0 2 2 2 0 HI0933-like protein Dynamin_M PF01031.20 CDI78500.1 - 3.1e-73 246.5 0.0 1.9e-72 243.9 0.0 2.1 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 CDI78500.1 - 1.7e-31 109.5 0.0 4e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CDI78500.1 - 5.9e-30 103.3 3.7 7.7e-30 102.9 2.0 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain T3SS_needle_E PF08988.10 CDI78500.1 - 0.04 14.1 2.7 2 8.6 0.1 2.9 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle TRAM_LAG1_CLN8 PF03798.16 CDI78502.1 - 1.6e-23 83.5 14.8 2.1e-23 83.1 14.8 1.1 1 0 0 1 1 1 1 TLC domain Pkinase PF00069.25 CDI78504.1 - 3.9e-32 111.7 0.0 5e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78504.1 - 2e-23 83.0 0.0 2.9e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI78504.1 - 1.6e-10 40.3 0.0 2.5e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI78504.1 - 0.00098 19.1 0.0 0.029 14.3 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family ABC1 PF03109.16 CDI78504.1 - 0.025 14.8 0.0 0.055 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Pox_ser-thr_kin PF05445.11 CDI78504.1 - 0.06 12.3 0.1 0.092 11.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Nsp1_C PF05064.13 CDI78505.1 - 3.5e-12 46.1 5.3 3.5e-12 46.1 5.3 1.9 2 1 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 CDI78505.1 - 1.1e-08 35.8 149.5 0.0088 16.9 31.9 6.8 1 1 3 5 5 4 1 Nucleoporin FG repeat region Exonuc_VII_L PF02601.15 CDI78505.1 - 0.067 12.7 6.5 0.13 11.8 6.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit PHM7_cyt PF14703.6 CDI78505.1 - 0.18 12.0 0.9 0.29 11.3 0.9 1.3 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF1664 PF07889.12 CDI78505.1 - 0.18 11.8 8.5 0.92 9.5 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Nup88 PF10168.9 CDI78505.1 - 0.44 8.3 9.7 0.6 7.8 9.7 1.0 1 0 0 1 1 1 0 Nuclear pore component TLE_N PF03920.15 CDI78505.1 - 0.86 9.7 5.4 0.59 10.2 3.6 1.6 1 1 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain V_ATPase_I PF01496.19 CDI78505.1 - 0.91 7.4 6.0 1.2 7.0 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ABC_tran_CTD PF16326.5 CDI78505.1 - 1.1 9.5 9.1 0.19 12.0 0.3 3.0 1 1 2 3 3 3 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 CDI78505.1 - 1.3 9.1 9.4 0.61 10.1 5.1 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 CDI78505.1 - 8.3 6.6 8.5 8.8 6.5 5.4 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Aconitase PF00330.20 CDI78506.1 - 1.4e-155 518.8 0.0 2.5e-144 481.7 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDI78506.1 - 3.7e-23 82.3 0.0 7.6e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain TSP_1 PF00090.19 CDI78509.1 - 2.3e-09 37.3 13.6 0.0014 18.8 1.3 5.0 3 0 0 3 3 3 3 Thrombospondin type 1 domain G-patch_2 PF12656.7 CDI78510.1 - 0.00042 20.4 0.0 0.00042 20.4 0.0 2.4 2 0 0 2 2 2 1 G-patch domain RAB3GAP2_N PF14655.6 CDI78510.1 - 0.0024 17.2 2.0 0.0024 17.2 2.0 1.7 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4834 PF16118.5 CDI78510.1 - 0.21 12.5 12.1 0.92 10.5 0.6 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Trypan_PARP PF05887.11 CDI78511.1 - 0.00039 20.4 0.1 0.00061 19.8 0.1 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) RNase_PH PF01138.21 CDI78511.1 - 0.0092 16.5 5.9 0.083 13.4 5.9 2.0 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF1645 PF07816.11 CDI78511.1 - 0.036 14.6 2.3 0.055 14.1 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Bud13 PF09736.9 CDI78511.1 - 0.086 13.2 5.8 0.069 13.5 4.5 1.4 1 1 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex NESP55 PF06390.12 CDI78511.1 - 0.13 11.8 11.1 0.18 11.4 11.1 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Ycf4 PF02392.16 CDI78511.1 - 5.3 6.6 6.0 2.6 7.6 0.7 2.2 1 1 0 2 2 2 0 Ycf4 PRR20 PF15708.5 CDI78513.1 - 0.00049 20.1 6.3 0.002 18.1 6.3 2.0 1 0 0 1 1 1 1 Proline-rich protein family 20 OSCP PF00213.18 CDI78514.1 - 0.0073 16.4 0.5 0.033 14.3 0.3 2.1 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit HTH_Tnp_Tc3_2 PF01498.18 CDI78514.1 - 0.18 12.0 0.4 0.71 10.2 0.1 2.0 2 0 0 2 2 2 0 Transposase DnaJ PF00226.31 CDI78515.1 - 7.7e-14 51.6 0.3 1.5e-13 50.6 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain TFIIA PF03153.13 CDI78516.1 - 0.0071 16.4 28.3 0.0089 16.1 28.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit 3-PAP PF12578.8 CDI78516.1 - 0.012 15.3 3.0 0.012 15.3 3.0 1.9 2 0 0 2 2 2 0 Myotubularin-associated protein tRNA-synt_1f PF01921.18 CDI78516.1 - 0.023 13.6 1.0 0.03 13.2 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (K) XRN_M PF17846.1 CDI78516.1 - 0.058 12.3 6.4 0.087 11.8 6.4 1.2 1 0 0 1 1 1 0 Xrn1 helical domain EMP24_GP25L PF01105.24 CDI78516.1 - 0.2 11.6 3.9 1.1 9.1 0.7 2.3 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Tsg PF04668.12 CDI78516.1 - 0.23 12.1 4.5 0.11 13.1 1.5 2.0 3 0 0 3 3 3 0 Twisted gastrulation (Tsg) protein conserved region 60KD_IMP PF02096.20 CDI78516.1 - 0.3 11.0 5.3 0.53 10.2 5.3 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein ABC2_membrane_3 PF12698.7 CDI78516.1 - 0.35 9.9 0.4 0.51 9.4 0.4 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3573 PF12097.8 CDI78516.1 - 0.46 9.3 3.1 0.62 8.8 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Striatin PF08232.12 CDI78516.1 - 0.59 10.7 14.7 0.22 12.1 11.8 1.7 2 0 0 2 2 2 0 Striatin family FlxA PF14282.6 CDI78516.1 - 0.96 9.5 42.0 0.04 13.9 30.2 3.1 3 0 0 3 3 3 0 FlxA-like protein Kinesin_assoc PF16183.5 CDI78516.1 - 1.4 9.1 7.9 0.61 10.2 4.6 1.9 2 0 0 2 2 2 0 Kinesin-associated TerB_C PF15615.6 CDI78516.1 - 7 6.9 21.3 13 6.1 17.5 2.6 1 1 1 2 2 2 0 TerB-C domain V_ATPase_I PF01496.19 CDI78516.1 - 7.8 4.3 8.5 10 3.9 8.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4179 PF13786.6 CDI78516.1 - 8.4 6.9 16.2 0.36 11.3 3.0 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4179) NYN_YacP PF05991.11 CDI78516.1 - 8.6 6.3 13.5 19 5.1 0.1 3.0 2 1 0 3 3 3 0 YacP-like NYN domain TTRAP PF14203.6 CDI78518.1 - 0.016 15.2 0.3 3.2 7.8 0.0 2.4 1 1 1 2 2 2 0 Putative tranposon-transfer assisting protein Ras PF00071.22 CDI78519.1 - 7e-08 32.2 0.0 9.7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI78519.1 - 1.5e-07 31.7 0.0 2e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CAP_N PF01213.19 CDI78519.1 - 0.62 9.5 5.9 0.29 10.6 2.4 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal NOA36 PF06524.12 CDI78519.1 - 4.4 6.6 14.5 6.3 6.0 14.5 1.3 1 0 0 1 1 1 0 NOA36 protein Ribosomal_60s PF00428.19 CDI78519.1 - 8.3 7.1 38.4 0.089 13.4 16.5 2.4 2 1 0 2 2 2 0 60s Acidic ribosomal protein 5_nucleotid_C PF02872.18 CDI78520.1 - 0.19 11.9 1.6 0.87 9.8 1.6 2.1 1 1 0 1 1 1 0 5'-nucleotidase, C-terminal domain CS PF04969.16 CDI78522.1 - 3e-06 28.1 0.1 4.4e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 CS domain COX4 PF02936.14 CDI78522.1 - 0.02 14.9 1.1 0.032 14.2 1.1 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV YEATS PF03366.16 CDI78523.1 - 0.001 19.0 17.1 17 5.5 0.0 8.6 7 2 0 8 8 8 1 YEATS family DUF608 PF04685.13 CDI78523.1 - 0.26 10.4 2.3 11 5.1 0.2 2.7 2 0 0 2 2 2 0 Glycosyl-hydrolase family 116, catalytic region TFIIS_M PF07500.14 CDI78523.1 - 0.37 11.3 8.8 5.6 7.5 0.1 4.5 4 1 1 5 5 5 0 Transcription factor S-II (TFIIS), central domain PepSY_2 PF13670.6 CDI78523.1 - 0.73 9.9 2.8 2 8.5 0.5 3.0 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Cas_Cmr5 PF09701.10 CDI78523.1 - 2 8.7 7.5 5.3 7.4 0.1 4.1 3 1 1 4 4 4 0 CRISPR-associated protein (Cas_Cmr5) Potassium_chann PF11404.8 CDI78523.1 - 3.2 7.6 9.5 2.6 7.9 0.4 4.8 5 0 0 5 5 5 0 Potassium voltage-gated channel DUF1168 PF06658.12 CDI78524.1 - 1.8e-22 79.6 23.1 1.8e-22 79.6 23.1 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1168) DUF2722 PF10846.8 CDI78525.1 - 0.00051 19.1 3.1 0.00051 19.1 3.1 11.2 7 3 1 8 8 8 2 Protein of unknown function (DUF2722) HEAT PF02985.22 CDI78525.1 - 0.00067 19.7 14.0 0.034 14.4 0.1 4.9 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 CDI78525.1 - 0.0015 18.6 0.1 0.012 15.6 0.1 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_binding PF10199.9 CDI78525.1 - 3.6 8.2 0.0 3.6 8.2 0.0 6.8 3 3 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 SpoIIE PF07228.12 CDI78526.1 - 0.001 19.0 1.0 0.0039 17.1 0.1 2.7 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CDI78526.1 - 0.0065 16.1 0.0 0.97 9.0 0.0 2.5 2 0 0 2 2 2 2 Protein phosphatase 2C CTP_transf_1 PF01148.20 CDI78527.1 - 4.9e-26 92.1 7.7 3e-25 89.5 6.4 2.6 2 1 0 2 2 2 1 Cytidylyltransferase family SprA-related PF12118.8 CDI78527.1 - 0.0017 17.6 13.0 0.0017 17.6 13.0 3.4 3 0 0 3 3 3 1 SprA-related family TFIIA PF03153.13 CDI78527.1 - 0.0028 17.7 19.4 0.0028 17.7 19.4 3.4 3 1 0 3 3 2 2 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 CDI78527.1 - 0.0043 17.1 10.8 0.0043 17.1 10.8 4.6 5 0 0 5 5 5 1 Uncharacterized protein conserved in bacteria (DUF2076) Trp_oprn_chp PF09534.10 CDI78527.1 - 0.029 14.2 30.3 0.11 12.2 6.3 4.4 4 0 0 4 4 4 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Otopetrin PF03189.13 CDI78527.1 - 0.071 11.9 0.0 6 5.6 0.0 2.3 2 1 0 2 2 2 0 Otopetrin CPSF100_C PF13299.6 CDI78527.1 - 0.091 12.9 13.5 0.8 9.9 1.4 3.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 CDI78527.1 - 0.1 12.6 9.5 3 7.9 2.2 3.0 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Apt1 PF10351.9 CDI78527.1 - 0.24 10.2 15.7 0.25 10.2 0.6 2.5 2 1 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI78527.1 - 2.9 6.6 23.2 0.63 8.7 5.7 3.1 3 0 0 3 3 3 0 Presenilin Tyrosinase PF00264.20 CDI78527.1 - 3 8.1 8.6 4.6 7.5 4.7 2.3 2 0 0 2 2 2 0 Common central domain of tyrosinase Connexin PF00029.19 CDI78527.1 - 4.7 6.9 9.2 7.7 6.2 0.4 2.5 3 0 0 3 3 3 0 Connexin DAG_kinase_N PF14513.6 CDI78527.1 - 5.8 7.1 19.3 7.6 6.7 5.2 3.1 3 0 0 3 3 3 0 Diacylglycerol kinase N-terminus DUF2370 PF10176.9 CDI78527.1 - 8.6 5.9 11.1 1.2 8.7 1.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2370) Helicase_C PF00271.31 CDI78528.1 - 1.6e-15 57.4 0.0 7.8e-15 55.2 0.0 2.2 1 1 1 2 2 2 1 Helicase conserved C-terminal domain Spt20 PF12090.8 CDI78528.1 - 0.34 10.5 40.6 1.2 8.6 13.4 2.4 2 0 0 2 2 2 0 Spt20 family Velvet PF11754.8 CDI78528.1 - 0.61 10.0 11.5 0.018 15.0 2.9 2.2 2 0 0 2 2 2 0 Velvet factor BAF1_ABF1 PF04684.13 CDI78528.1 - 3.7 6.5 20.1 0.17 10.9 8.6 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Vfa1 PF08432.10 CDI78528.1 - 5.2 7.4 16.4 1.7 8.9 9.3 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Activator_LAG-3 PF11498.8 CDI78528.1 - 5.7 5.8 49.1 0.31 10.0 25.6 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Pex14_N PF04695.13 CDI78528.1 - 7.9 7.1 30.1 2.8 8.6 15.4 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HRDC PF00570.23 CDI78529.1 - 0.00012 22.0 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 HRDC domain EF-hand_7 PF13499.6 CDI78530.1 - 7.3e-05 23.1 0.0 0.0072 16.8 0.0 3.8 3 1 1 4 4 4 2 EF-hand domain pair Coilin_N PF15862.5 CDI78530.1 - 0.0073 16.1 19.3 0.021 14.6 0.6 3.7 3 0 0 3 3 3 2 Coilin N-terminus Presenilin PF01080.17 CDI78530.1 - 0.027 13.2 21.4 0.12 11.1 0.6 3.1 3 0 0 3 3 3 0 Presenilin EPL1 PF10513.9 CDI78530.1 - 0.14 12.6 23.0 1.2 9.5 4.4 3.7 3 0 0 3 3 3 0 Enhancer of polycomb-like Spt20 PF12090.8 CDI78530.1 - 0.27 10.8 48.5 0.015 14.9 13.9 3.6 3 0 0 3 3 3 0 Spt20 family MecA PF05389.12 CDI78530.1 - 0.6 9.7 13.8 0.17 11.5 0.3 3.3 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) Pex14_N PF04695.13 CDI78530.1 - 0.93 10.1 40.1 0.035 14.8 2.0 4.1 3 1 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CPSF100_C PF13299.6 CDI78530.1 - 3.3 7.9 18.7 0.54 10.4 0.7 3.8 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal Ripply PF14998.6 CDI78530.1 - 4.6 8.0 12.2 5.8 7.6 5.1 3.0 2 0 0 2 2 2 0 Transcription Regulator POX PF07526.11 CDI78530.1 - 8.4 7.0 26.0 7.6 7.1 10.8 3.8 3 0 0 3 3 3 0 Associated with HOX Trp_oprn_chp PF09534.10 CDI78532.1 - 0.009 15.8 1.4 0.009 15.8 1.4 6.8 5 3 0 5 5 5 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PAF-AH_p_II PF03403.13 CDI78532.1 - 0.73 8.3 4.9 1.8 7.0 4.9 1.6 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II CAF1 PF04857.20 CDI78532.1 - 9.6 5.3 12.5 3 6.9 5.0 3.1 3 0 0 3 3 3 0 CAF1 family ribonuclease DUF755 PF05501.11 CDI78533.1 - 0.0042 17.4 8.7 0.0042 17.4 8.7 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF755) RAP PF08373.10 CDI78533.1 - 0.16 12.1 0.0 1.8 8.7 0.0 2.5 3 0 0 3 3 3 0 RAP domain PAN_1 PF00024.26 CDI78535.1 - 9.6e-63 208.1 76.5 6.1e-08 32.5 1.0 11.2 6 5 5 11 11 11 11 PAN domain PAN_4 PF14295.6 CDI78535.1 - 2.6e-46 155.3 63.0 3.7e-06 26.7 0.6 11.6 11 0 0 11 11 11 11 PAN domain PAN_2 PF08276.11 CDI78535.1 - 1e-12 47.9 73.3 0.0039 17.3 0.6 11.8 11 1 0 11 11 11 8 PAN-like domain Ras PF00071.22 CDI78537.1 - 8.4e-05 22.2 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 Ras family FixO PF02433.15 CDI78537.1 - 0.1 12.1 0.1 0.12 11.8 0.1 1.3 1 1 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO zf_C2H2_6 PF18450.1 CDI78538.1 - 0.26 11.1 3.2 0.58 9.9 3.2 1.5 1 0 0 1 1 1 0 Zinc Finger domain PAP_assoc PF03828.19 CDI78539.1 - 0.06 13.6 0.0 0.54 10.5 0.0 2.3 2 0 0 2 2 2 0 Cid1 family poly A polymerase Activator_LAG-3 PF11498.8 CDI78539.1 - 3.5 6.5 28.8 6.6 5.6 28.8 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CDC45 PF02724.14 CDI78540.1 - 0.011 14.0 0.6 0.012 13.9 0.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI78540.1 - 0.03 13.1 1.7 0.035 12.9 1.7 1.2 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI78540.1 - 0.036 12.9 4.5 0.043 12.7 4.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain GREB1 PF15782.5 CDI78540.1 - 0.14 9.2 4.6 0.15 9.1 4.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI78540.1 - 0.17 10.4 4.9 0.24 9.9 4.9 1.3 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 CDI78540.1 - 0.24 9.5 2.0 0.25 9.4 2.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Tim54 PF11711.8 CDI78540.1 - 0.32 9.7 2.3 0.54 9.0 2.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RAP1 PF07218.11 CDI78540.1 - 0.37 9.0 7.8 0.4 8.9 7.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.9 CDI78540.1 - 0.42 10.2 25.3 0.12 12.0 21.9 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Peptidase_S64 PF08192.11 CDI78540.1 - 0.64 8.4 3.4 0.67 8.4 3.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 PAP1 PF08601.10 CDI78540.1 - 0.65 9.7 11.7 0.94 9.1 11.7 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 LTV PF04180.14 CDI78540.1 - 1.1 8.9 10.5 1.7 8.3 10.5 1.2 1 0 0 1 1 1 0 Low temperature viability protein TFIIF_alpha PF05793.12 CDI78540.1 - 1.3 7.6 12.5 2.1 6.9 12.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BAF1_ABF1 PF04684.13 CDI78540.1 - 1.4 7.9 8.9 1.9 7.4 8.9 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RGS12_usC PF16612.5 CDI78540.1 - 1.7 9.1 14.9 1.3 9.5 13.0 1.7 1 1 1 2 2 2 0 C-terminal unstructured region of RGS12 RR_TM4-6 PF06459.12 CDI78540.1 - 3.4 7.4 14.0 0.98 9.2 10.8 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 CDI78540.1 - 9.4 6.3 17.0 2.2 8.3 12.7 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 LRR_4 PF12799.7 CDI78542.1 - 4.1e-35 119.2 47.9 9.6e-05 22.7 0.0 12.4 9 4 6 15 15 15 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI78542.1 - 3.1e-34 116.5 49.4 4.2e-06 26.4 0.1 9.6 9 1 1 10 10 10 8 Leucine rich repeat LRR_9 PF14580.6 CDI78542.1 - 5.4e-33 113.9 3.9 6.8e-12 45.2 0.0 6.6 5 1 1 6 6 6 5 Leucine-rich repeat LRR_6 PF13516.6 CDI78542.1 - 1.9e-05 24.3 32.4 1.2 9.4 0.0 11.0 12 0 0 12 12 12 5 Leucine Rich repeat LRR_1 PF00560.33 CDI78542.1 - 0.00044 20.4 33.2 2.8 8.8 0.0 12.7 13 0 0 13 13 13 2 Leucine Rich Repeat DUF5437 PF17505.2 CDI78542.1 - 6.3 6.9 6.3 32 4.6 1.6 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5437) PG_isomerase_N PF18353.1 CDI78543.1 - 0.021 15.2 0.3 0.021 15.2 0.3 2.1 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain Ocular_alb PF02101.15 CDI78543.1 - 2 7.3 8.5 0.34 9.8 2.4 2.1 2 0 0 2 2 2 0 Ocular albinism type 1 protein Spore_III_AB PF09548.10 CDI78543.1 - 4.5 7.4 8.0 9.3 6.3 8.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Macoilin PF09726.9 CDI78544.1 - 1.6 7.2 5.9 1.8 7.0 5.9 1.1 1 0 0 1 1 1 0 Macoilin family Roughex PF06020.11 CDI78544.1 - 2.4 7.2 9.5 3.2 6.8 9.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Herpes_LMP1 PF05297.11 CDI78544.1 - 5.8 6.0 14.0 8 5.5 14.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RAP1 PF07218.11 CDI78544.1 - 6.3 4.9 12.1 7 4.8 12.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FSA_C PF10479.9 CDI78544.1 - 10 4.1 9.7 11 4.0 9.7 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RskA PF10099.9 CDI78547.1 - 0.0028 18.0 12.8 0.0035 17.6 12.8 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Shadoo PF14999.6 CDI78547.1 - 0.28 11.3 4.3 0.34 11.0 4.3 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective TERB2 PF15101.6 CDI78547.1 - 0.64 10.0 14.2 0.64 10.0 14.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Connexin PF00029.19 CDI78547.1 - 0.86 9.3 4.1 0.8 9.4 4.1 1.1 1 0 0 1 1 1 0 Connexin Usp PF00582.26 CDI78547.1 - 0.89 10.1 7.2 2.7 8.5 7.2 1.7 1 1 0 1 1 1 0 Universal stress protein family Serinc PF03348.15 CDI78547.1 - 1.1 8.1 3.5 1 8.2 3.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4799 PF16056.5 CDI78547.1 - 3 6.9 11.8 3.1 6.9 11.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) Suf PF05843.14 CDI78547.1 - 3.4 7.6 13.8 3.2 7.6 13.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 CDI78547.1 - 3.4 8.7 11.5 5.2 8.1 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CDI78547.1 - 4.7 7.9 14.4 1.5 9.5 11.9 1.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Presenilin PF01080.17 CDI78547.1 - 4.8 5.8 11.7 4.8 5.8 11.7 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI78547.1 - 6.1 6.7 32.0 7 6.5 32.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MAJIN PF15077.6 CDI78547.1 - 6.9 6.4 10.1 7.6 6.2 10.1 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein CLN3 PF02487.17 CDI78547.1 - 7 5.6 4.9 7.8 5.4 4.9 1.1 1 0 0 1 1 1 0 CLN3 protein CLN3 PF02487.17 CDI78548.1 - 0.0062 15.6 6.0 0.068 12.2 3.2 2.9 2 0 0 2 2 2 1 CLN3 protein DUF4484 PF14831.6 CDI78548.1 - 0.029 14.4 11.6 0.79 9.7 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) DUF913 PF06025.12 CDI78548.1 - 0.085 11.8 9.5 0.29 10.1 6.3 2.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) DUF2052 PF09747.9 CDI78548.1 - 0.1 12.7 14.8 1.7 8.8 12.7 2.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF2370 PF10176.9 CDI78548.1 - 1.1 8.8 6.6 0.87 9.2 4.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) BORG_CEP PF14957.6 CDI78548.1 - 1.3 10.2 12.2 8.6 7.5 0.1 2.7 2 0 0 2 2 2 0 Cdc42 effector Zip PF02535.22 CDI78548.1 - 2.9 7.0 10.1 11 5.2 0.0 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter Afi1 PF07792.12 CDI78548.1 - 4.2 7.9 14.7 8.2 6.9 11.0 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Ctr PF04145.15 CDI78548.1 - 4.4 7.9 10.9 8.3 7.0 5.7 2.8 2 0 0 2 2 2 0 Ctr copper transporter family PIP5K PF01504.18 CDI78548.1 - 4.8 6.3 12.3 3.9 6.6 8.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2828 PF11443.8 CDI78548.1 - 5 5.1 13.0 0.44 8.6 7.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF2828) DUF4050 PF13259.6 CDI78548.1 - 5.5 7.3 21.2 8.3 6.7 13.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) Folliculin PF11704.8 CDI78548.1 - 8 6.3 16.9 38 4.1 12.4 2.8 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF3801 PF12687.7 CDI78548.1 - 8.5 6.4 18.1 22 5.1 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) DUF3597 PF12200.8 CDI78549.1 - 0.028 15.0 2.0 0.036 14.6 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DEC-1_N PF04625.13 CDI78549.1 - 0.091 11.8 3.7 0.089 11.8 3.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region IMCp PF12314.8 CDI78550.1 - 7.9e-17 61.3 51.8 1.2e-12 47.9 26.9 2.1 1 1 1 2 2 2 2 Inner membrane complex protein IMCp PF12314.8 CDI78551.1 - 3.1e-27 94.7 56.0 1.4e-25 89.4 38.9 2.3 1 1 1 2 2 2 2 Inner membrane complex protein STPPase_N PF16891.5 CDI78553.1 - 0.081 13.4 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain GHMP_kinases_N PF00288.26 CDI78554.1 - 0.0002 21.5 0.0 0.0002 21.5 0.0 7.3 7 1 1 8 8 8 1 GHMP kinases N terminal domain SPX PF03105.19 CDI78554.1 - 0.0037 17.2 14.2 0.0037 17.2 14.2 3.6 1 1 1 2 2 2 1 SPX domain DUF4449 PF14613.6 CDI78554.1 - 0.0081 16.3 0.3 0.0081 16.3 0.3 5.1 4 2 0 5 5 5 1 Protein of unknown function (DUF4449) RskA PF10099.9 CDI78554.1 - 0.018 15.4 0.4 0.018 15.4 0.4 7.6 3 3 3 6 6 6 0 Anti-sigma-K factor rskA Aminotran_5 PF00266.19 CDI78556.1 - 1.1e-18 67.4 0.0 2e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V SR-25 PF10500.9 CDI78556.1 - 7.5e-06 25.7 10.1 1e-05 25.3 10.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Band_3_cyto PF07565.13 CDI78556.1 - 0.064 13.0 6.7 0.1 12.4 6.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Corona_nucleoca PF00937.18 CDI78556.1 - 0.069 12.2 5.9 0.09 11.8 4.8 1.7 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein DUF2203 PF09969.9 CDI78556.1 - 0.078 13.7 2.4 0.2 12.4 2.4 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) IMUP PF15761.5 CDI78556.1 - 0.11 13.2 15.6 0.21 12.3 15.6 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Pinin_SDK_memA PF04696.13 CDI78556.1 - 0.5 10.4 9.3 0.83 9.7 9.3 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region POX PF07526.11 CDI78556.1 - 0.72 10.4 8.1 1.4 9.5 8.1 1.4 1 0 0 1 1 1 0 Associated with HOX Gti1_Pac2 PF09729.9 CDI78556.1 - 0.78 9.8 7.6 1.2 9.2 7.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family NMN_transporter PF04973.12 CDI78558.1 - 0.014 15.4 0.1 0.033 14.2 0.1 1.6 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter APC1_C PF18122.1 CDI78558.1 - 0.086 12.8 1.1 0.2 11.6 1.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain TFIIA PF03153.13 CDI78558.1 - 0.3 11.0 33.6 0.61 10.0 29.1 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Velvet PF11754.8 CDI78558.1 - 0.36 10.7 8.8 0.74 9.7 8.8 1.6 1 0 0 1 1 1 0 Velvet factor MFS_1 PF07690.16 CDI78558.1 - 0.4 9.5 16.6 1.8 7.4 1.1 2.2 2 0 0 2 2 2 0 Major Facilitator Superfamily DDHD PF02862.17 CDI78558.1 - 0.45 10.6 5.5 2.1 8.5 6.0 1.8 2 0 0 2 2 2 0 DDHD domain Neur_chan_memb PF02932.16 CDI78558.1 - 2.4 8.1 4.1 1.9 8.5 2.1 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Mus7 PF09462.10 CDI78558.1 - 5.5 5.7 10.8 7.6 5.3 10.8 1.2 1 0 0 1 1 1 0 Mus7/MMS22 family SARAF PF06682.12 CDI78558.1 - 5.5 6.5 9.8 2.4 7.7 0.0 2.5 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4083 PF13314.6 CDI78560.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) EphA2_TM PF14575.6 CDI78560.1 - 0.077 13.9 1.2 62 4.6 0.0 3.8 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 CDI78560.1 - 0.2 11.5 5.5 2.3 8.0 0.1 2.7 3 0 0 3 3 3 0 Transmembrane protein 51 DUF308 PF03729.13 CDI78560.1 - 0.36 11.2 7.3 0.27 11.6 2.8 2.8 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) CcmH PF03918.14 CDI78560.1 - 0.76 9.1 2.7 6.5 6.0 0.1 3.0 3 0 0 3 3 3 0 Cytochrome C biogenesis protein FeoB_associated PF12669.7 CDI78560.1 - 1.8 9.0 5.8 8.8 6.8 0.0 3.8 4 0 0 4 4 4 0 FeoB-associated Cys-rich membrane protein LapA_dom PF06305.11 CDI78560.1 - 7.7 6.4 8.2 10 6.0 0.1 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF501 PF04417.12 CDI78563.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF501) CCDC24 PF15669.5 CDI78563.1 - 0.79 9.6 3.8 0.32 10.8 0.2 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Peptidase_C58 PF03543.14 CDI78564.1 - 6.4 6.4 11.6 0.4 10.4 0.3 2.6 3 0 0 3 3 3 0 Yersinia/Haemophilus virulence surface antigen AAA_lid_4 PF17864.1 CDI78565.1 - 0.014 15.1 2.4 3.3 7.5 0.5 2.6 2 0 0 2 2 2 0 RuvB AAA lid domain DUF4477 PF14780.6 CDI78565.1 - 0.044 13.4 0.0 0.17 11.5 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) HEAT PF02985.22 CDI78565.1 - 7.3 7.1 8.9 51 4.5 0.0 5.4 5 0 0 5 5 5 0 HEAT repeat Coatomer_WDAD PF04053.14 CDI78566.1 - 0.012 14.7 0.3 0.012 14.7 0.3 1.8 2 0 0 2 2 2 0 Coatomer WD associated region ANAPC4_WD40 PF12894.7 CDI78566.1 - 0.023 15.0 0.0 0.3 11.4 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI78566.1 - 0.11 13.4 4.5 2.2 9.3 0.1 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat TPH PF13868.6 CDI78567.1 - 7.6e-07 28.0 78.9 7.6e-07 28.0 78.9 3.3 2 1 1 3 3 3 2 Trichohyalin-plectin-homology domain CLASP_N PF12348.8 CDI78568.1 - 0.045 13.3 6.2 0.36 10.3 0.4 3.9 2 1 1 4 4 4 0 CLASP N terminal FAP206 PF12018.8 CDI78570.1 - 3.4e-07 30.1 0.0 0.002 17.7 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function YHS PF04945.13 CDI78570.1 - 0.15 12.2 0.0 0.62 10.2 0.0 2.1 1 0 0 1 1 1 0 YHS domain AMA-1 PF02430.15 CDI78572.1 - 2.4e-66 224.6 0.0 5e-66 223.6 0.1 1.4 2 0 0 2 2 2 1 Apical membrane antigen 1 WD40 PF00400.32 CDI78573.1 - 1.1e-08 35.6 12.8 3e-05 24.7 0.1 5.0 4 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78573.1 - 0.007 16.6 0.0 4.1 7.8 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SfLAP PF11139.8 CDI78573.1 - 0.0085 15.6 13.6 0.021 14.3 13.6 1.6 1 0 0 1 1 1 1 Sap, sulfolipid-1-addressing protein RAB3GAP2_N PF14655.6 CDI78573.1 - 0.12 11.6 1.3 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Cyt_bd_oxida_II PF02322.15 CDI78573.1 - 0.73 9.1 10.9 1.3 8.3 10.9 1.3 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II DUF4205 PF13898.6 CDI78574.1 - 8.4e-31 107.2 0.1 8.4e-31 107.2 0.1 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4205) SUIM_assoc PF16619.5 CDI78574.1 - 0.02 15.0 2.2 0.02 15.0 2.2 4.9 3 2 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 FAM176 PF14851.6 CDI78574.1 - 0.76 9.4 6.5 1.6 8.4 0.1 2.5 2 0 0 2 2 2 0 FAM176 family Clr2 PF10383.9 CDI78574.1 - 1.1 10.0 3.5 0.73 10.6 0.2 2.2 2 0 0 2 2 2 0 Transcription-silencing protein Clr2 Macoilin PF09726.9 CDI78575.1 - 0.89 8.0 29.1 0.98 7.9 29.1 1.0 1 0 0 1 1 1 0 Macoilin family Roughex PF06020.11 CDI78575.1 - 1.2 8.1 10.3 1.4 8.0 10.3 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Zip PF02535.22 CDI78575.1 - 2.3 7.3 9.2 2.6 7.2 9.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CytochromB561_N PF09786.9 CDI78575.1 - 8.3 5.3 21.6 8.5 5.2 21.6 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal RskA PF10099.9 CDI78575.1 - 9.7 6.4 26.0 11 6.3 25.4 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI78576.1 - 0.0003 21.2 4.0 0.00042 20.6 4.0 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA BRF1 PF07741.13 CDI78576.1 - 0.11 12.9 0.2 0.18 12.2 0.2 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF4769 PF15992.5 CDI78576.1 - 0.28 11.0 7.1 0.4 10.4 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) RIFIN PF02009.16 CDI78576.1 - 5.7 6.7 18.5 9.1 6.1 18.5 1.3 1 0 0 1 1 1 0 Rifin Ribosomal_60s PF00428.19 CDI78576.1 - 6 7.5 13.4 0.19 12.3 6.2 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein MMR_HSR1 PF01926.23 CDI78577.1 - 2.5e-13 50.1 0.0 6.9e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 CDI78577.1 - 2.2e-11 43.6 15.9 1.7e-06 27.7 3.8 3.7 3 0 0 3 3 3 3 GTP1/OBG TFIIA PF03153.13 CDI78577.1 - 2.4e-05 24.5 62.8 0.0065 16.5 12.7 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit FeoB_N PF02421.18 CDI78577.1 - 2.6e-05 23.8 0.0 9.4e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Myticin-prepro PF10690.9 CDI78577.1 - 0.56 10.5 9.3 1.2 9.4 7.8 2.4 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel MecA PF05389.12 CDI78577.1 - 0.79 9.3 11.8 0.29 10.8 0.9 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) MCU PF04678.13 CDI78577.1 - 1.9 8.5 12.2 11 6.1 0.3 2.6 2 0 0 2 2 2 0 Mitochondrial calcium uniporter PH_4 PF15404.6 CDI78577.1 - 4.8 6.9 14.7 0.03 14.1 2.3 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain Spt20 PF12090.8 CDI78578.1 - 0.068 12.8 7.1 0.086 12.4 7.1 1.1 1 0 0 1 1 1 0 Spt20 family ImpA_N PF06812.12 CDI78578.1 - 0.07 13.2 3.2 0.16 12.1 3.2 1.6 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system tRNA_bind_2 PF13725.6 CDI78578.1 - 0.26 10.9 4.9 0.42 10.3 4.9 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain CRPA PF05745.11 CDI78578.1 - 0.38 10.8 1.5 0.72 9.9 1.5 1.4 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) DUF2448 PF10476.9 CDI78578.1 - 6 6.7 8.7 0.41 10.5 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) Ribosomal_L4 PF00573.22 CDI78579.1 - 7.4e-09 35.6 1.6 2.9e-06 27.1 0.3 2.8 1 1 2 3 3 3 2 Ribosomal protein L4/L1 family SPX PF03105.19 CDI78579.1 - 0.19 11.6 11.2 0.31 10.9 11.2 1.2 1 0 0 1 1 1 0 SPX domain Peptidase_S64 PF08192.11 CDI78579.1 - 0.22 10.0 7.0 0.29 9.6 7.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 CDI78579.1 - 0.91 8.3 9.2 1.2 7.9 9.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SUIM_assoc PF16619.5 CDI78581.1 - 0.01 15.9 2.1 0.01 15.9 2.1 5.5 4 1 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 HSP20 PF00011.21 CDI78582.1 - 9.2e-12 45.0 0.0 1.5e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDI78582.1 - 0.00011 21.6 0.1 0.00046 19.7 0.0 2.1 2 1 0 2 2 2 1 HSP20-like domain found in ArsA DUF2890 PF11081.8 CDI78585.1 - 0.021 15.0 2.1 0.021 15.0 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) OmpH PF03938.14 CDI78585.1 - 0.027 14.8 36.4 0.11 12.8 14.9 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Spot_14 PF07084.12 CDI78585.1 - 0.074 13.2 3.3 0.41 10.8 0.0 2.9 2 1 1 3 3 3 0 Thyroid hormone-inducible hepatic protein Spot 14 MCU PF04678.13 CDI78585.1 - 0.18 11.9 9.2 1 9.5 1.7 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Secretin_N_2 PF07655.13 CDI78585.1 - 0.77 10.3 12.3 5.9 7.5 2.4 2.7 2 1 0 2 2 2 0 Secretin N-terminal domain AAA_23 PF13476.6 CDI78585.1 - 0.88 10.0 9.3 4.8 7.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Ribosomal_60s PF00428.19 CDI78585.1 - 1.2 9.7 63.4 2.2 8.9 12.5 4.5 4 0 0 4 4 4 0 60s Acidic ribosomal protein Spt20 PF12090.8 CDI78585.1 - 1.5 8.4 38.4 2.6 7.6 23.2 2.5 2 0 0 2 2 2 0 Spt20 family Activator_LAG-3 PF11498.8 CDI78585.1 - 2 7.3 47.5 0.86 8.5 28.5 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 FPN1 PF06963.12 CDI78585.1 - 2.8 6.4 5.8 0.39 9.2 1.0 1.9 2 0 0 2 2 2 0 Ferroportin1 (FPN1) OATP PF03137.20 CDI78585.1 - 3.8 5.7 6.3 1.7 6.9 0.8 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TFIIA PF03153.13 CDI78586.1 - 0.00012 22.2 12.7 0.00016 21.8 12.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI78586.1 - 0.0004 20.4 21.2 0.00048 20.2 21.2 1.0 1 0 0 1 1 1 1 SPX domain RskA PF10099.9 CDI78586.1 - 0.012 15.9 0.9 0.017 15.4 0.9 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Med15 PF09606.10 CDI78586.1 - 0.018 13.8 15.6 0.022 13.5 15.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Sin_N PF04801.13 CDI78586.1 - 0.02 14.1 11.0 0.026 13.7 11.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Plasmodium_Vir PF05795.11 CDI78586.1 - 0.041 13.3 10.4 0.067 12.6 10.4 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MAP65_ASE1 PF03999.12 CDI78586.1 - 0.057 12.1 21.1 0.069 11.8 21.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DivIC PF04977.15 CDI78586.1 - 0.078 12.8 10.7 0.11 12.2 10.7 1.2 1 0 0 1 1 1 0 Septum formation initiator PAP1 PF08601.10 CDI78586.1 - 0.13 11.9 33.1 0.18 11.5 33.1 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Suf PF05843.14 CDI78586.1 - 0.75 9.7 17.3 0.11 12.4 5.6 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Amino_oxidase PF01593.24 CDI78587.1 - 6.6e-36 124.6 20.1 9e-18 64.8 0.0 4.8 3 2 1 4 4 4 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI78587.1 - 9.4e-15 54.6 5.0 1.9e-14 53.6 0.8 4.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDI78587.1 - 0.00073 20.1 0.2 0.012 16.2 0.4 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 CDI78587.1 - 0.0011 18.4 0.2 1 8.7 0.1 4.5 3 1 0 3 3 3 1 ThiF family Thi4 PF01946.17 CDI78587.1 - 0.0051 16.1 0.1 0.013 14.7 0.1 1.6 1 0 0 1 1 1 1 Thi4 family N6_N4_Mtase PF01555.18 CDI78589.1 - 0.0034 17.1 0.0 0.41 10.3 0.0 3.1 3 2 0 3 3 3 2 DNA methylase NifU PF01106.17 CDI78591.1 - 2.2e-16 59.8 1.4 1.8e-06 28.0 0.2 3.5 2 2 1 3 3 3 3 NifU-like domain PET PF06297.14 CDI78591.1 - 0.05 13.9 0.2 0.098 13.0 0.2 1.4 1 0 0 1 1 1 0 PET Domain TFIIA PF03153.13 CDI78591.1 - 0.13 12.3 3.8 0.15 12.0 3.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI78592.1 - 2.7e-07 30.8 62.0 0.0019 18.2 7.6 5.3 5 0 0 5 5 5 4 SPX domain FAM60A PF15396.6 CDI78592.1 - 0.0011 19.1 5.0 0.0011 19.1 5.0 5.9 6 1 1 7 7 7 1 Protein Family FAM60A Sporozoite_P67 PF05642.11 CDI78592.1 - 0.0013 16.9 4.6 0.0013 16.9 4.6 7.2 5 3 1 6 6 6 2 Sporozoite P67 surface antigen zf-RING_2 PF13639.6 CDI78593.1 - 0.0036 17.6 1.7 0.01 16.1 1.7 1.8 1 0 0 1 1 1 1 Ring finger domain RskA PF10099.9 CDI78593.1 - 0.015 15.6 0.3 0.015 15.6 0.3 27.7 12 7 10 22 22 22 0 Anti-sigma-K factor rskA Peptidase_S8 PF00082.22 CDI78596.1 - 4.7e-17 62.2 5.3 6.4e-17 61.8 5.3 1.2 1 0 0 1 1 1 1 Subtilase family Atrophin-1 PF03154.15 CDI78596.1 - 0.16 10.3 4.3 0.23 9.7 4.3 1.2 1 0 0 1 1 1 0 Atrophin-1 family TFIIF_alpha PF05793.12 CDI78597.1 - 1.6 7.2 12.9 3 6.3 12.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF883 PF05957.13 CDI78598.1 - 0.061 13.9 4.2 0.061 13.9 4.2 1.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) TetR_C_20 PF17925.1 CDI78599.1 - 0.41 11.0 7.8 0.68 10.3 7.8 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain CDC27 PF09507.10 CDI78599.1 - 0.82 9.0 29.9 1.1 8.5 29.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AFG1_ATPase PF03969.16 CDI78600.1 - 2.9e-44 151.5 0.0 4.2e-44 150.9 0.0 1.1 1 0 0 1 1 1 1 AFG1-like ATPase Pro-rich PF15240.6 CDI78600.1 - 0.017 15.4 19.9 0.03 14.6 19.9 1.4 1 0 0 1 1 1 0 Proline-rich DUF1674 PF07896.12 CDI78601.1 - 4.6e-07 30.2 7.9 2.2e-06 28.1 7.9 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) TFIIA PF03153.13 CDI78601.1 - 0.0006 19.9 20.3 0.00068 19.7 20.3 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI78601.1 - 0.065 12.2 16.1 0.11 11.4 16.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SPX PF03105.19 CDI78601.1 - 0.13 12.2 8.9 0.14 12.1 8.9 1.1 1 0 0 1 1 1 0 SPX domain eIF-3_zeta PF05091.12 CDI78601.1 - 0.15 11.0 3.8 0.16 10.9 3.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 CDI78601.1 - 0.61 9.9 7.2 0.84 9.4 7.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI78601.1 - 0.78 9.7 5.5 1.1 9.3 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SARAF PF06682.12 CDI78601.1 - 0.87 9.2 16.4 0.52 9.9 14.6 1.4 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Mlh1_C PF16413.5 CDI78601.1 - 1.1 8.6 6.4 1.9 7.8 6.4 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus GREB1 PF15782.5 CDI78601.1 - 1.2 6.2 6.3 1.3 6.1 6.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI78601.1 - 1.4 7.7 8.1 1.8 7.3 8.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI78601.1 - 1.5 9.8 9.3 2.2 9.3 7.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF3043 PF11241.8 CDI78601.1 - 2 8.4 4.3 3.6 7.6 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) SpoIIP PF07454.11 CDI78601.1 - 2.6 7.5 7.0 4.2 6.7 7.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 CDI78601.1 - 2.8 6.1 14.7 3.7 5.7 14.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3464 PF11947.8 CDI78601.1 - 3.2 7.5 9.9 32 4.2 8.7 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Hamartin PF04388.12 CDI78601.1 - 4.7 5.7 12.6 5.5 5.5 12.6 1.0 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 CDI78601.1 - 7.2 5.2 14.2 9 4.8 14.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 CDI78601.1 - 8.4 5.1 13.1 11 4.7 13.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SNARE PF05739.19 CDI78602.1 - 2.8e-06 27.2 0.7 9.4e-06 25.5 0.2 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 CDI78602.1 - 0.0051 16.5 3.4 0.011 15.4 1.4 2.2 2 1 0 2 2 2 1 Syntaxin DUF148 PF02520.17 CDI78602.1 - 0.019 15.1 3.6 0.33 11.1 0.5 2.5 2 1 0 2 2 2 0 Domain of unknown function DUF148 Turandot PF07240.11 CDI78602.1 - 0.035 14.1 0.1 3.5 7.7 0.0 2.6 1 1 1 2 2 2 0 Stress-inducible humoral factor Turandot DUF1043 PF06295.12 CDI78602.1 - 0.058 13.4 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) M20_dimer PF07687.14 CDI78602.1 - 0.075 13.0 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase dimerisation domain SKA2 PF16740.5 CDI78602.1 - 0.088 12.6 2.7 0.24 11.2 0.3 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Apolipoprotein PF01442.18 CDI78602.1 - 0.11 12.4 3.2 0.2 11.5 3.2 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain BNR_assoc_N PF14873.6 CDI78604.1 - 0.39 10.4 10.8 3.8 7.2 0.8 3.1 1 1 1 3 3 3 0 N-terminal domain of BNR-repeat neuraminidase tRNA-synt_1d PF00750.19 CDI78607.1 - 9.2e-117 389.9 0.0 1.2e-116 389.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CDI78607.1 - 2.3e-25 89.1 0.0 6.8e-25 87.6 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CDI78607.1 - 7.2e-14 52.1 0.0 2.5e-13 50.4 0.0 1.9 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1 PF00133.22 CDI78607.1 - 0.021 13.1 0.0 0.032 12.5 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CDI78607.1 - 0.024 14.0 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DapB_N PF01113.20 CDI78607.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus SUIM_assoc PF16619.5 CDI78608.1 - 0.014 15.5 6.7 0.014 15.5 6.7 3.5 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF5629 PF18629.1 CDI78608.1 - 0.031 14.8 0.1 0.031 14.8 0.1 2.9 4 0 0 4 4 4 0 Family of unknown function (DUF5629) Chorein_N PF12624.7 CDI78608.1 - 0.08 13.1 1.1 0.19 11.8 1.1 1.6 1 0 0 1 1 1 0 N-terminal region of Chorein or VPS13 Pox_A12 PF04651.13 CDI78608.1 - 1.5 8.8 8.5 0.28 11.2 3.7 2.0 2 0 0 2 2 2 0 Poxvirus A12 protein Chorion_2 PF03964.15 CDI78609.1 - 0.014 16.2 14.0 0.014 16.2 14.0 10.6 2 1 6 8 8 8 0 Chorion family 2 LSM PF01423.22 CDI78610.1 - 0.0022 17.6 0.0 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 LSM domain AF-4 PF05110.13 CDI78610.1 - 0.013 13.7 25.8 0.0044 15.2 7.8 2.3 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Secretin_N_2 PF07655.13 CDI78610.1 - 9.5 6.8 27.8 2.6 8.7 2.2 2.6 3 0 0 3 3 3 0 Secretin N-terminal domain SUIM_assoc PF16619.5 CDI78612.1 - 0.00014 21.9 4.2 0.00014 21.9 4.2 4.8 3 1 1 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 TraU PF06834.11 CDI78612.1 - 0.021 14.1 7.2 0.37 10.0 0.1 3.1 2 1 1 3 3 3 0 TraU protein ANAPC_CDC26 PF10471.9 CDI78612.1 - 0.029 15.2 15.0 0.029 15.2 15.0 3.7 4 0 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 BING4CT PF08149.11 CDI78612.1 - 0.23 11.3 0.1 0.23 11.3 0.1 2.0 2 0 0 2 2 2 0 BING4CT (NUC141) domain ORC_WH_C PF18137.1 CDI78612.1 - 0.33 11.0 12.0 0.77 9.8 3.9 2.3 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal GntP_permease PF02447.16 CDI78612.1 - 0.36 9.5 0.7 1.2 7.7 0.1 2.0 2 0 0 2 2 2 0 GntP family permease SRP9-21 PF05486.12 CDI78612.1 - 3.1 8.2 7.6 11 6.5 0.4 3.4 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) SARAF PF06682.12 CDI78612.1 - 3.7 7.1 22.6 0.5 10.0 6.3 2.5 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Orf78 PF06024.12 CDI78612.1 - 3.8 7.9 9.1 22 5.4 0.2 3.6 3 1 1 4 4 4 0 Orf78 (ac78) Rpp20 PF12328.8 CDI78613.1 - 0.011 15.7 1.1 0.011 15.7 1.1 6.8 8 1 0 8 8 8 0 Rpp20 subunit of nuclear RNase MRP and P CAF1 PF04857.20 CDI78614.1 - 1.1e-23 83.9 19.6 2.3e-16 59.9 11.3 2.8 3 0 0 3 3 3 2 CAF1 family ribonuclease NAM-associated PF14303.6 CDI78614.1 - 1.4e-11 45.4 7.5 0.002 18.9 0.0 4.7 2 1 1 3 3 3 2 No apical meristem-associated C-terminal domain SR-25 PF10500.9 CDI78614.1 - 0.00017 21.3 11.6 0.00017 21.3 11.6 4.9 3 2 2 5 5 4 1 Nuclear RNA-splicing-associated protein PIEZO PF15917.5 CDI78614.1 - 0.0032 17.0 15.4 0.0032 17.0 15.4 2.0 2 0 0 2 2 2 1 Piezo DUF5069 PF16798.5 CDI78614.1 - 0.14 12.3 8.2 0.37 11.0 8.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5069) FB_lectin PF07367.11 CDI78614.1 - 0.53 10.2 3.9 1.1 9.2 3.9 1.5 1 0 0 1 1 1 0 Fungal fruit body lectin Peptidase_S49_N PF08496.10 CDI78614.1 - 0.64 10.1 14.0 1.1e+02 2.8 15.5 2.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI78614.1 - 2 7.3 18.2 4.8 6.1 18.2 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MEIOC PF15189.6 CDI78614.1 - 3 7.5 14.1 7.9 6.1 14.1 1.7 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC LMBR1 PF04791.16 CDI78614.1 - 4.1 6.2 6.2 7.9 5.3 6.2 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Lin-8 PF03353.15 CDI78614.1 - 4.4 6.8 37.1 0.098 12.2 18.1 3.3 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist BUD22 PF09073.10 CDI78614.1 - 9 5.5 46.4 0.031 13.6 2.3 3.2 3 0 0 3 3 3 0 BUD22 Cwf_Cwc_15 PF04889.12 CDI78614.1 - 9.1 5.9 34.0 1.2 8.8 21.0 3.1 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.32 CDI78615.1 - 6.8e-07 29.9 0.0 0.031 15.1 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78615.1 - 0.00013 22.2 0.0 0.15 12.4 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain NUC205 PF08168.11 CDI78615.1 - 0.00047 19.6 2.4 0.51 9.9 2.3 2.6 2 0 0 2 2 2 2 NUC205 domain Dehydrin PF00257.19 CDI78615.1 - 0.21 12.1 14.2 0.046 14.3 6.2 2.2 2 0 0 2 2 2 0 Dehydrin SR-25 PF10500.9 CDI78615.1 - 1.2 8.8 12.3 2 8.0 12.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4813 PF16072.5 CDI78615.1 - 4.1 7.0 49.7 3 7.4 29.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4813) bZIP_1 PF00170.21 CDI78616.1 - 0.083 13.0 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor SUIM_assoc PF16619.5 CDI78617.1 - 0.014 15.4 5.0 0.014 15.4 5.0 9.7 6 3 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 DUF327 PF03885.13 CDI78618.1 - 0.0075 16.2 7.0 0.011 15.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF327) Androgen_recep PF02166.16 CDI78618.1 - 0.026 13.4 14.5 0.031 13.2 14.5 1.1 1 0 0 1 1 1 0 Androgen receptor SUIM_assoc PF16619.5 CDI78618.1 - 0.14 12.3 13.8 0.34 11.0 13.5 1.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PAPS_reduct PF01507.19 CDI78619.1 - 4.5e-16 59.4 8.5 2.6e-14 53.6 8.5 3.1 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF5308 PF17233.2 CDI78619.1 - 7.6e-05 23.0 1.3 7.6e-05 23.0 1.3 2.5 2 1 0 2 2 1 1 Family of unknown function (DUF5308) DUF4746 PF15928.5 CDI78619.1 - 0.00032 20.2 3.1 0.00041 19.9 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) FAM163 PF15069.6 CDI78619.1 - 0.00047 20.6 11.5 0.00047 20.6 11.5 1.9 2 1 0 2 2 1 1 FAM163 family DUF2828 PF11443.8 CDI78619.1 - 0.0034 15.5 11.1 0.0042 15.3 11.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) CDC45 PF02724.14 CDI78619.1 - 0.0048 15.2 7.3 0.0091 14.3 6.2 1.7 2 0 0 2 2 2 1 CDC45-like protein EPL1 PF10513.9 CDI78619.1 - 0.0065 16.9 10.7 0.0065 16.9 10.7 2.0 2 0 0 2 2 2 1 Enhancer of polycomb-like Hid1 PF12722.7 CDI78619.1 - 0.0079 14.4 6.6 0.01 14.0 6.6 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein EFTUD2 PF16004.5 CDI78619.1 - 0.0086 16.7 12.3 0.11 13.1 11.6 2.3 2 0 0 2 2 2 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Rrn6 PF10214.9 CDI78619.1 - 0.011 14.3 15.1 0.013 14.0 15.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF3464 PF11947.8 CDI78619.1 - 0.013 15.3 5.4 0.013 15.3 5.4 1.9 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 CSG2 PF16965.5 CDI78619.1 - 0.018 14.0 3.7 0.024 13.6 3.7 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator TCP PF03634.13 CDI78619.1 - 0.037 14.6 18.5 0.083 13.4 18.5 1.5 1 1 0 1 1 1 0 TCP family transcription factor BORG_CEP PF14957.6 CDI78619.1 - 0.06 14.5 8.1 0.091 13.9 5.7 2.0 2 0 0 2 2 2 0 Cdc42 effector CBP_BcsG PF11658.8 CDI78619.1 - 0.072 11.5 7.4 0.1 11.0 7.4 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Otopetrin PF03189.13 CDI78619.1 - 0.078 11.8 8.1 0.14 11.0 8.1 1.4 1 0 0 1 1 1 0 Otopetrin SID-1_RNA_chan PF13965.6 CDI78619.1 - 0.1 11.0 4.1 0.13 10.7 4.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 CDI78619.1 - 0.13 11.2 11.7 0.25 10.3 11.7 1.4 1 0 0 1 1 1 0 CLN3 protein PepSY_TM PF03929.16 CDI78619.1 - 0.25 11.0 8.1 1.3 8.6 4.4 2.2 2 0 0 2 2 2 0 PepSY-associated TM region EMC3_TMCO1 PF01956.16 CDI78619.1 - 0.34 10.6 7.3 0.64 9.7 7.3 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Peptidase_S64 PF08192.11 CDI78619.1 - 0.42 9.1 12.2 0.012 14.1 6.3 1.4 2 0 0 2 2 2 0 Peptidase family S64 Tim54 PF11711.8 CDI78619.1 - 0.42 9.3 12.6 0.91 8.2 12.6 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4045 PF13254.6 CDI78619.1 - 0.56 9.8 12.6 0.42 10.2 8.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) OATP PF03137.20 CDI78619.1 - 0.57 8.4 6.1 0.11 10.8 2.1 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family RIC3 PF15361.6 CDI78619.1 - 0.64 10.4 9.7 1 9.7 7.4 2.1 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 eIF-3_zeta PF05091.12 CDI78619.1 - 0.7 8.8 20.4 1.3 8.0 20.4 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Paramyxo_ncap PF00973.19 CDI78619.1 - 0.9 8.4 10.1 1.2 8.0 10.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Gti1_Pac2 PF09729.9 CDI78619.1 - 1.1 9.4 18.5 2 8.5 17.3 1.8 2 0 0 2 2 2 0 Gti1/Pac2 family DUF4050 PF13259.6 CDI78619.1 - 1.1 9.5 15.4 2.1 8.6 12.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) DUF2370 PF10176.9 CDI78619.1 - 1.2 8.7 7.3 2.4 7.8 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) HCO3_cotransp PF00955.21 CDI78619.1 - 1.3 7.7 5.3 1.9 7.2 5.3 1.2 1 0 0 1 1 1 0 HCO3- transporter family Connexin PF00029.19 CDI78619.1 - 1.4 8.6 15.6 2.6 7.8 14.6 1.8 2 0 0 2 2 2 0 Connexin Sec62 PF03839.16 CDI78619.1 - 1.8 8.0 15.4 3.5 7.1 15.4 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 TERB2 PF15101.6 CDI78619.1 - 2.1 8.3 23.0 0.29 11.2 18.0 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 V_ATPase_I PF01496.19 CDI78619.1 - 2.2 6.1 24.5 3.7 5.3 24.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LAP1C PF05609.12 CDI78619.1 - 2.5 7.1 21.9 0.26 10.3 17.4 1.5 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) EBP50_C PF09007.11 CDI78619.1 - 3.3 8.7 17.4 30 5.6 0.0 2.3 2 0 0 2 2 2 0 EBP50, C-terminal CCDC53 PF10152.9 CDI78619.1 - 5.6 7.4 24.5 0.044 14.2 11.6 2.8 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex FAM176 PF14851.6 CDI78619.1 - 6.3 6.5 10.9 3.9 7.1 8.8 1.7 2 0 0 2 2 2 0 FAM176 family DUF3381 PF11861.8 CDI78619.1 - 6.9 6.4 24.1 0.62 9.8 19.3 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF3381) Peptidase_U57 PF05582.12 CDI78619.1 - 7.5 5.7 12.3 12 5.1 12.3 1.2 1 0 0 1 1 1 0 YabG peptidase U57 TFB6 PF17110.5 CDI78619.1 - 7.7 6.2 10.9 19 5.0 10.9 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Peroxin-13_N PF04088.13 CDI78619.1 - 8.1 6.7 10.6 6.3 7.1 7.5 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Membralin PF09746.9 CDI78619.1 - 9 5.2 12.3 14 4.6 12.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF2126 PF09899.9 CDI78619.1 - 9.1 4.2 12.8 13 3.7 12.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) zf-HIT PF04438.16 CDI78620.1 - 0.00075 19.3 11.3 0.0012 18.6 11.3 1.3 1 0 0 1 1 1 1 HIT zinc finger Herpes_LMP1 PF05297.11 CDI78620.1 - 0.54 9.4 2.1 0.79 8.9 2.1 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF382 PF04037.13 CDI78621.1 - 0.0024 18.0 1.6 0.62 10.2 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF382) GHMP_kinases_C PF08544.13 CDI78621.1 - 0.029 14.7 0.0 0.75 10.2 0.0 2.6 2 0 0 2 2 2 0 GHMP kinases C terminal Interferon PF00143.19 CDI78621.1 - 0.17 12.1 3.4 7.5 6.7 0.2 2.4 2 0 0 2 2 2 0 Interferon alpha/beta domain CAAP1 PF15335.6 CDI78621.1 - 0.34 11.5 3.1 16 6.1 0.3 2.7 2 0 0 2 2 2 0 Caspase activity and apoptosis inhibitor 1 Lipoprotein_2 PF00921.17 CDI78621.1 - 0.43 10.1 4.0 0.41 10.1 0.2 2.0 2 0 0 2 2 2 0 Borrelia lipoprotein MA3 PF02847.17 CDI78622.1 - 3.7e-09 36.6 0.6 8.4e-09 35.4 0.6 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 CDI78622.1 - 4e-09 36.4 0.8 6.3e-09 35.8 0.0 1.7 2 0 0 2 2 2 1 MIF4G domain RskA PF10099.9 CDI78623.1 - 4.7e-06 27.0 1.6 4.7e-06 27.0 1.6 10.2 4 3 3 7 7 7 2 Anti-sigma-K factor rskA F-box-like PF12937.7 CDI78623.1 - 0.00022 21.0 3.5 0.00089 19.1 3.5 2.1 1 0 0 1 1 1 1 F-box-like Pex14_N PF04695.13 CDI78623.1 - 0.0086 16.7 15.1 0.0086 16.7 15.1 9.3 8 2 2 10 10 10 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Myb_DNA-binding PF00249.31 CDI78624.1 - 1.1e-05 25.5 0.8 2.1e-05 24.6 0.8 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain CDC24_OB1 PF17246.2 CDI78625.1 - 0.066 13.3 0.1 0.066 13.3 0.1 2.4 2 1 0 2 2 2 0 Cell division control protein 24, OB domain 1 Neurensin PF14927.6 CDI78625.1 - 0.084 12.6 0.2 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 Neurensin Mis14 PF08641.12 CDI78625.1 - 0.59 10.4 19.9 0.56 10.5 12.0 2.3 2 0 0 2 2 2 0 Kinetochore protein Mis14 like DUF3040 PF11239.8 CDI78625.1 - 0.82 10.0 4.1 0.96 9.8 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3040) RskA PF10099.9 CDI78625.1 - 2.2 8.5 31.9 0.51 10.6 15.9 3.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA GET2 PF08690.10 CDI78625.1 - 3.2 7.3 28.8 1.2 8.7 0.1 2.2 1 1 1 2 2 2 0 GET complex subunit GET2 Connexin PF00029.19 CDI78625.1 - 4.5 6.9 10.2 9.7 5.9 3.9 2.1 2 0 0 2 2 2 0 Connexin CAP_GLY PF01302.25 CDI78626.1 - 1.6e-10 40.8 0.2 8.5e-08 32.1 0.0 2.2 2 0 0 2 2 2 2 CAP-Gly domain DUF2859 PF11072.8 CDI78626.1 - 0.015 15.1 0.1 0.024 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) RXLR PF16810.5 CDI78626.1 - 0.043 14.2 0.9 0.043 14.2 0.9 2.0 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity RAB3GAP2_N PF14655.6 CDI78626.1 - 0.1 11.9 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Roughex PF06020.11 CDI78626.1 - 0.36 9.9 3.9 0.46 9.5 3.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein HAUS6_N PF14661.6 CDI78626.1 - 2.7 7.5 7.7 3.9 7.0 7.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF1874 PF08960.10 CDI78627.1 - 6.6 6.9 8.0 4.4 7.5 5.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1874) Glycos_transf_2 PF00535.26 CDI78628.1 - 2e-25 89.6 0.0 4.7e-25 88.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDI78628.1 - 3.7e-08 33.7 0.0 6.2e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 CDI78628.1 - 5.7e-06 25.9 1.3 1e-05 25.1 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 CDI78628.1 - 6.2e-05 23.0 0.0 0.00019 21.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 NTP_transf_3 PF12804.7 CDI78628.1 - 0.056 13.8 0.0 0.097 13.0 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain Glyco_transf_21 PF13506.6 CDI78628.1 - 0.061 12.8 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 DnaJ PF00226.31 CDI78629.1 - 8.9e-08 32.2 0.1 3.1e-06 27.2 0.0 2.4 2 0 0 2 2 2 1 DnaJ domain PAS PF00989.25 CDI78629.1 - 0.16 12.0 0.1 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 PAS fold Pkinase PF00069.25 CDI78630.1 - 3.4e-60 203.6 0.9 3.1e-52 177.6 0.4 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78630.1 - 1.5e-27 96.6 0.6 5.6e-22 78.3 0.2 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase McyA_C PF12593.8 CDI78630.1 - 0.00064 19.5 1.7 0.083 12.7 1.6 2.6 2 0 0 2 2 2 1 Microcystin synthetase C terminal Haspin_kinase PF12330.8 CDI78630.1 - 0.029 13.3 0.1 0.071 12.0 0.1 1.7 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CDI78630.1 - 0.029 14.3 0.0 0.029 14.3 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDI78630.1 - 0.036 12.9 0.3 1.4 7.6 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase PAT1 PF09770.9 CDI78630.1 - 5.7 5.1 11.9 8.3 4.5 11.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Metallophos PF00149.28 CDI78631.1 - 5.7e-05 23.7 0.0 9.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RecQ_Zn_bind PF16124.5 CDI78633.1 - 4.9e-09 36.8 1.1 4.9e-09 36.8 1.1 4.5 4 0 0 4 4 4 1 RecQ zinc-binding DUF4638 PF15472.6 CDI78633.1 - 0.016 15.0 0.2 0.016 15.0 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4638) NAD_binding_6 PF08030.12 CDI78633.1 - 0.029 14.5 0.0 0.12 12.4 0.0 2.1 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Mem_trans PF03547.18 CDI78633.1 - 0.39 9.1 6.5 2.7 6.3 0.2 3.0 3 0 0 3 3 3 0 Membrane transport protein SAPS PF04499.15 CDI78633.1 - 4.1 6.1 12.7 0.081 11.7 2.5 2.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Sin3_corepress PF08295.12 CDI78634.1 - 1.5e-23 82.7 0.2 5.4e-23 80.9 0.2 2.0 1 0 0 1 1 1 1 Sin3 family co-repressor Adaptin_binding PF10199.9 CDI78634.1 - 0.047 14.3 18.3 0.58 10.8 15.9 3.6 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 FERM_F2 PF18377.1 CDI78634.1 - 0.32 10.9 3.6 0.94 9.4 3.6 1.7 1 0 0 1 1 1 0 FERM F2 acyl-CoA binding protein-like domain DUF4407 PF14362.6 CDI78634.1 - 2.7 7.3 13.6 7.9 5.7 13.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_G_3 PF13385.6 CDI78635.1 - 2.1e-15 57.1 0.0 3.9e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 CDI78635.1 - 0.00066 20.3 0.1 0.0033 18.0 0.0 2.3 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.23 CDI78635.1 - 0.0031 17.7 0.0 0.0089 16.2 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain PI3_PI4_kinase PF00454.27 CDI78636.1 - 2.2e-31 109.6 0.0 1.1e-30 107.2 0.0 2.2 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CDI78636.1 - 2.6e-10 39.9 0.0 7.1e-10 38.5 0.0 1.8 1 0 0 1 1 1 1 FATC domain RskA PF10099.9 CDI78636.1 - 1.7 8.9 0.0 0.52 10.6 3.6 36.5 16 10 9 26 26 26 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI78637.1 - 0.0039 17.2 6.9 0.0039 17.2 6.9 8.1 5 2 2 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 KNOX2 PF03791.13 CDI78638.1 - 0.12 11.9 0.1 17 5.0 0.0 3.1 3 0 0 3 3 3 0 KNOX2 domain Adeno_PV PF03910.13 CDI78639.1 - 0.12 11.0 5.7 0.18 10.5 5.7 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV ALMT PF11744.8 CDI78639.1 - 1.6 7.5 5.3 2.2 7.0 5.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Phostensin PF13914.6 CDI78639.1 - 2.5 8.7 7.1 2.8 8.6 5.4 1.9 1 1 1 2 2 2 0 Phostensin PP1-binding and SH3-binding region Ribosomal_60s PF00428.19 CDI78639.1 - 3.8 8.2 10.6 1.4 9.6 8.0 1.6 1 1 1 2 2 2 0 60s Acidic ribosomal protein DUF4171 PF13775.6 CDI78640.1 - 0.0022 18.4 10.7 0.0022 18.4 10.7 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4171) Macoilin PF09726.9 CDI78640.1 - 3 6.3 37.3 0.75 8.3 25.4 2.1 2 0 0 2 2 2 0 Macoilin family AAA_16 PF13191.6 CDI78642.1 - 3.6e-05 24.2 0.1 4.4e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 CDI78642.1 - 0.0031 17.7 0.0 1.4 9.1 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI78642.1 - 0.19 11.2 0.0 3.6 7.0 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family Ribosomal_60s PF00428.19 CDI78642.1 - 0.82 10.3 12.4 2.4 8.8 12.4 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein Sugar_tr PF00083.24 CDI78643.1 - 2.5e-80 270.6 22.7 5e-80 269.6 22.7 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDI78643.1 - 2.7e-18 66.1 46.1 1.5e-16 60.3 33.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Lin-8 PF03353.15 CDI78643.1 - 1.9 7.9 22.3 3.3 7.2 22.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI78643.1 - 2.8 4.9 18.0 3.7 4.6 18.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FAM60A PF15396.6 CDI78643.1 - 4.7 7.2 12.5 10 6.1 12.5 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Neur_chan_memb PF02932.16 CDI78643.1 - 8.9 6.3 14.0 38 4.2 14.0 2.0 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region eIF-3_zeta PF05091.12 CDI78643.1 - 9.5 5.1 18.0 14 4.5 18.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDHD PF02862.17 CDI78645.1 - 9.2e-05 22.7 19.1 0.0024 18.1 7.8 2.1 2 0 0 2 2 2 2 DDHD domain TFIIA PF03153.13 CDI78645.1 - 0.00015 22.0 82.5 0.0091 16.0 51.5 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit SAPS PF04499.15 CDI78645.1 - 0.00041 19.3 8.3 0.0026 16.6 1.9 2.0 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein FAIM1 PF06905.13 CDI78645.1 - 0.012 15.3 0.0 0.012 15.3 0.0 1.7 2 0 0 2 2 1 0 Fas apoptotic inhibitory molecule (FAIM1) AF-4 PF05110.13 CDI78645.1 - 0.031 12.4 35.3 0.043 11.9 3.9 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein V_ATPase_I PF01496.19 CDI78645.1 - 0.19 9.6 33.2 0.074 11.0 18.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4746 PF15928.5 CDI78645.1 - 0.38 10.1 21.9 1.5 8.1 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CNDH2_C PF16858.5 CDI78645.1 - 0.62 9.9 30.9 1.8 8.3 5.8 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CCSAP PF15748.5 CDI78645.1 - 0.64 10.1 41.3 1.8 8.7 7.7 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SID-1_RNA_chan PF13965.6 CDI78645.1 - 0.68 8.3 8.4 1.2 7.4 2.9 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 MecA PF05389.12 CDI78645.1 - 0.76 9.4 21.9 0.16 11.6 0.6 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) BORG_CEP PF14957.6 CDI78645.1 - 0.85 10.8 23.6 2.7 9.1 3.9 2.4 2 0 0 2 2 2 0 Cdc42 effector SWI-SNF_Ssr4 PF08549.10 CDI78645.1 - 0.93 8.1 35.4 0.37 9.4 21.6 2.1 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) Neur_chan_memb PF02932.16 CDI78645.1 - 1 9.4 28.6 0.39 10.7 1.9 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF572 PF04502.13 CDI78645.1 - 1.8 8.1 29.7 1.2 8.6 15.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) MMR1 PF08505.10 CDI78645.1 - 2.9 8.1 42.2 4.9 7.4 8.7 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein SAGA-Tad1 PF12767.7 CDI78645.1 - 3.4 7.3 28.3 2.1 8.0 2.5 2.1 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF3807 PF12720.7 CDI78645.1 - 3.8 7.8 44.9 2.8 8.2 11.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Hamartin PF04388.12 CDI78645.1 - 3.8 6.1 28.1 2.4 6.7 2.9 2.0 2 0 0 2 2 2 0 Hamartin protein NPR3 PF03666.13 CDI78645.1 - 4 6.1 33.1 0.3 9.8 15.2 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4045 PF13254.6 CDI78645.1 - 4.7 6.8 33.4 4.2 6.9 19.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) DAG_kinase_N PF14513.6 CDI78645.1 - 4.9 7.3 30.1 0.82 9.9 1.5 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Presenilin PF01080.17 CDI78645.1 - 5.7 5.6 45.5 3.2 6.4 9.9 2.1 2 0 0 2 2 2 0 Presenilin Draxin PF15550.6 CDI78645.1 - 6.1 6.6 26.0 2 8.2 12.8 2.1 2 0 0 2 2 2 0 Draxin AbLIM_anchor PF16182.5 CDI78645.1 - 7.4 6.3 25.8 1.6 8.5 10.4 2.2 2 0 0 2 2 2 0 Putative adherens-junction anchoring region of AbLIM Endostatin PF06482.11 CDI78645.1 - 9.4 5.6 36.4 2.5 7.5 4.3 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF4207 PF13904.6 CDI78646.1 - 0.0068 16.1 8.6 0.0068 16.1 8.6 5.1 3 1 1 4 4 4 2 Domain of unknown function (DUF4207) zf-C3HC4_4 PF15227.6 CDI78649.1 - 8.3e-06 25.9 15.8 2.7e-05 24.2 15.8 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CDI78649.1 - 2.8e-05 24.3 15.6 5.4e-05 23.4 15.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CDI78649.1 - 0.00016 21.6 13.6 0.00048 20.1 13.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Mem_trans PF03547.18 CDI78649.1 - 0.0025 16.3 1.9 0.0025 16.3 1.9 2.2 2 0 0 2 2 2 1 Membrane transport protein zf-C3HC4 PF00097.25 CDI78649.1 - 0.006 16.4 15.7 0.012 15.5 15.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF755 PF05501.11 CDI78649.1 - 0.027 14.7 18.8 0.027 14.7 18.8 6.3 4 3 1 5 5 2 0 Domain of unknown function (DUF755) zf-C3HC4_3 PF13920.6 CDI78649.1 - 0.058 13.3 16.8 0.15 11.9 16.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MAP17 PF15807.5 CDI78649.1 - 0.063 13.5 0.1 0.063 13.5 0.1 3.6 3 1 0 3 3 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Prok-RING_4 PF14447.6 CDI78649.1 - 0.12 12.3 16.5 0.33 10.8 16.5 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CDI78649.1 - 0.15 12.0 17.7 2 8.3 17.7 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CPSF100_C PF13299.6 CDI78649.1 - 0.27 11.4 0.1 0.27 11.4 0.1 3.3 3 1 0 3 3 2 0 Cleavage and polyadenylation factor 2 C-terminal zf-rbx1 PF12678.7 CDI78649.1 - 0.28 11.5 18.0 1 9.7 18.0 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_14 PF17978.1 CDI78649.1 - 0.34 11.4 6.5 0.64 10.5 6.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 CDI78649.1 - 0.43 10.7 9.2 1.2 9.3 9.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 CDI78649.1 - 0.65 10.0 19.3 3.6 7.6 19.4 2.2 1 1 0 1 1 1 0 zinc-RING finger domain WW PF00397.26 CDI78650.1 - 2.6e-09 37.0 2.1 4.3e-09 36.3 2.1 1.4 1 0 0 1 1 1 1 WW domain Yip1 PF04893.17 CDI78650.1 - 2.3e-05 24.2 12.4 6.4e-05 22.7 12.3 1.9 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 CDI78650.1 - 0.0054 16.3 0.1 2.9 7.4 0.0 2.4 2 0 0 2 2 2 2 YIF1 BAF1_ABF1 PF04684.13 CDI78650.1 - 0.19 10.8 6.7 0.037 13.1 0.9 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Las1 PF04031.13 CDI78651.1 - 4.8e-43 146.9 0.3 4.8e-43 146.9 0.3 4.4 3 2 1 4 4 4 1 Las1-like RskA PF10099.9 CDI78651.1 - 0.00017 21.9 0.0 0.00017 21.9 0.0 11.5 4 3 3 10 10 10 1 Anti-sigma-K factor rskA Caldesmon PF02029.15 CDI78651.1 - 0.00019 20.3 3.2 0.00019 20.3 3.2 4.3 3 1 0 3 3 3 1 Caldesmon TFIIA PF03153.13 CDI78652.1 - 1.7e-08 34.9 47.5 0.00014 22.0 22.5 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI78652.1 - 0.00031 20.4 29.6 0.00031 20.4 29.6 3.3 2 1 0 2 2 1 1 Spt20 family SPX PF03105.19 CDI78652.1 - 0.0026 17.7 13.0 0.0026 17.7 13.0 2.1 2 0 0 2 2 2 1 SPX domain Plasmodium_Vir PF05795.11 CDI78652.1 - 0.0034 16.9 9.3 0.0034 16.9 9.3 2.3 2 1 0 2 2 1 1 Plasmodium vivax Vir protein N6_N4_Mtase PF01555.18 CDI78652.1 - 0.0047 16.7 2.4 1.7 8.3 0.0 2.3 2 0 0 2 2 2 2 DNA methylase GAGA_bind PF06217.12 CDI78652.1 - 0.011 16.0 8.6 0.011 16.0 8.6 2.7 2 1 1 3 3 3 0 GAGA binding protein-like family DUF3807 PF12720.7 CDI78652.1 - 0.012 15.9 21.0 0.012 15.9 21.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) BUD22 PF09073.10 CDI78652.1 - 0.043 13.1 42.2 0.48 9.7 18.1 2.2 2 0 0 2 2 2 0 BUD22 SLC12 PF03522.15 CDI78652.1 - 0.15 11.1 34.3 0.032 13.2 15.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 DUF572 PF04502.13 CDI78652.1 - 0.3 10.7 38.3 0.2 11.2 15.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) CNDH2_C PF16858.5 CDI78652.1 - 0.39 10.6 31.4 0.7 9.7 16.3 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DDRGK PF09756.9 CDI78652.1 - 0.63 9.6 41.4 0.045 13.3 18.6 2.3 2 0 0 2 2 2 0 DDRGK domain eIF-3_zeta PF05091.12 CDI78652.1 - 0.79 8.6 32.2 0.25 10.3 17.8 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CCDC84 PF14968.6 CDI78652.1 - 0.82 9.2 28.7 1.3 8.5 12.5 2.1 2 0 0 2 2 2 0 Coiled coil protein 84 DUF936 PF06075.12 CDI78652.1 - 1.2 7.9 38.3 0.46 9.3 13.1 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF936) Peptidase_U57 PF05582.12 CDI78652.1 - 1.3 8.2 20.8 0.069 12.4 9.5 2.3 2 0 0 2 2 2 0 YabG peptidase U57 SRP-alpha_N PF04086.13 CDI78652.1 - 1.3 8.8 46.4 0.57 10.1 20.1 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal MAP7 PF05672.11 CDI78652.1 - 2.2 8.0 53.1 0.14 11.8 27.1 2.9 3 0 0 3 3 3 0 MAP7 (E-MAP-115) family PAT1 PF09770.9 CDI78652.1 - 2.5 6.3 47.3 0.093 11.0 19.6 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 PIEZO PF15917.5 CDI78652.1 - 2.7 7.4 30.2 2.5 7.5 15.7 2.6 2 0 0 2 2 2 0 Piezo NARP1 PF12569.8 CDI78652.1 - 5.7 5.7 35.0 0.09 11.7 13.5 2.4 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 PIG-S PF10510.9 CDI78652.1 - 6.7 5.4 32.4 0.31 9.8 13.3 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein Peptidase_S64 PF08192.11 CDI78652.1 - 8.3 4.8 41.1 0.061 11.8 17.5 2.2 2 0 0 2 2 2 0 Peptidase family S64 SOG2 PF10428.9 CDI78652.1 - 9 5.4 42.2 0.089 12.0 11.2 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein Herpes_pp85 PF04637.12 CDI78654.1 - 4.8 5.5 10.5 1.9 6.8 3.2 2.3 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) BSP_II PF05432.11 CDI78654.1 - 6.9 6.3 28.4 0.039 13.6 19.3 1.9 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PhoLip_ATPase_C PF16212.5 CDI78655.1 - 7.1e-37 127.5 3.6 7.1e-37 127.5 3.6 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 CDI78655.1 - 2.5e-09 37.7 8.3 2.6e-06 27.9 1.0 3.9 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI78655.1 - 3.3e-08 33.5 0.0 5.7e-07 29.5 0.0 2.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDI78655.1 - 1.9e-07 30.8 0.3 9.4e-05 22.0 0.0 2.6 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase_3 PF08282.12 CDI78655.1 - 0.025 14.3 0.1 1.4 8.6 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 CDI78656.1 - 1.8e-13 50.1 31.4 2.5e-09 36.5 10.6 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDI78656.1 - 0.0069 15.3 16.2 0.051 12.4 0.0 3.8 2 2 2 4 4 4 2 Sugar (and other) transporter TRIQK PF15168.6 CDI78656.1 - 0.13 12.2 0.0 3.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family Methyltransf_8 PF05148.15 CDI78658.1 - 5.7e-57 193.1 0.0 9.5e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CDI78658.1 - 3.2e-05 24.5 0.4 0.0004 21.0 0.1 2.8 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI78658.1 - 0.00019 22.1 0.3 0.0063 17.2 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Sas10 PF09368.10 CDI78661.1 - 4.4e-22 78.3 9.6 4.4e-22 78.3 9.6 2.5 2 1 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CDI78661.1 - 9.9e-20 71.0 1.4 8e-19 68.1 1.4 2.7 1 0 0 1 1 1 1 Sas10/Utp3/C1D family RRM_1 PF00076.22 CDI78664.1 - 6.3e-16 58.0 0.0 1.1e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI78664.1 - 0.022 14.9 0.0 0.087 13.0 0.0 2.1 1 1 0 1 1 1 0 RNA recognition motif THRAP3_BCLAF1 PF15440.6 CDI78664.1 - 1.2 8.1 9.2 1.3 7.9 9.2 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Methyltransf_28 PF02636.17 CDI78670.1 - 8.1e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF4686 PF15742.5 CDI78670.1 - 0.25 10.4 6.8 0.56 9.3 6.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) Chorion_2 PF03964.15 CDI78671.1 - 0.00075 20.3 2.2 0.00075 20.3 2.2 5.9 5 1 1 6 6 6 1 Chorion family 2 Staphylokinase PF02821.16 CDI78671.1 - 0.022 15.2 0.3 0.36 11.3 0.0 2.4 2 0 0 2 2 2 0 Staphylokinase/Streptokinase family Transglut_core PF01841.19 CDI78671.1 - 0.036 14.5 0.2 0.17 12.3 0.2 2.2 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF1043 PF06295.12 CDI78672.1 - 0.038 14.0 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) RNase_PH PF01138.21 CDI78680.1 - 0.00036 21.0 3.6 0.0017 18.8 3.6 2.2 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF3446 PF11928.8 CDI78680.1 - 0.0038 17.5 41.4 0.14 12.4 7.4 3.4 3 0 0 3 3 3 3 Early growth response N-terminal domain Rotamase_2 PF13145.6 CDI78680.1 - 0.11 13.3 2.5 1 10.2 0.6 2.6 3 0 0 3 3 3 0 PPIC-type PPIASE domain SPX PF03105.19 CDI78680.1 - 0.25 11.2 10.4 0.48 10.3 10.4 1.4 1 1 0 1 1 1 0 SPX domain DUF4667 PF15700.5 CDI78680.1 - 0.31 11.1 0.1 0.31 11.1 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4667) Apt1 PF10351.9 CDI78680.1 - 0.37 9.6 9.6 10 4.8 10.2 2.0 1 1 0 1 1 1 0 Golgi-body localisation protein domain DUF1645 PF07816.11 CDI78680.1 - 0.94 10.0 24.1 2.1 8.9 2.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1645) SUZ PF12752.7 CDI78680.1 - 1.6 9.5 14.4 6.4 7.6 0.3 3.4 3 0 0 3 3 3 0 SUZ domain Dscam_C PF12355.8 CDI78680.1 - 2.8 8.9 18.2 3.3 8.7 2.7 3.3 3 0 0 3 3 3 0 Down syndrome cell adhesion molecule C terminal DUF4094 PF13334.6 CDI78681.1 - 0.0015 18.9 1.1 0.0028 18.0 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4094) SYS1 PF09801.9 CDI78681.1 - 0.1 12.7 0.2 0.1 12.7 0.2 2.0 2 1 0 2 2 2 0 Integral membrane protein S linking to the trans Golgi network tRNA_U5-meth_tr PF05958.11 CDI78682.1 - 0.00024 20.2 2.4 0.075 12.0 0.0 3.8 4 1 0 4 4 4 2 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 CDI78682.1 - 0.00056 19.7 0.0 0.00056 19.7 0.0 3.2 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI78682.1 - 0.00083 20.0 5.1 0.036 14.8 0.0 3.5 4 0 0 4 4 4 2 Methyltransferase domain MTS PF05175.14 CDI78682.1 - 0.0066 16.0 1.1 0.089 12.3 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase small domain Met_10 PF02475.16 CDI78682.1 - 0.026 14.3 0.0 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 Met-10+ like-protein Zip PF02535.22 CDI78682.1 - 0.033 13.4 0.0 0.033 13.4 0.0 3.9 5 0 0 5 5 5 0 ZIP Zinc transporter Methyltransf_15 PF09445.10 CDI78682.1 - 0.061 12.9 0.0 1.4 8.4 0.0 2.8 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 CDI78682.1 - 0.42 10.3 8.5 0.48 10.1 0.0 3.3 3 0 0 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Nuc_sug_transp PF04142.15 CDI78682.1 - 0.67 9.1 8.0 0.09 11.9 0.8 2.5 2 0 0 2 2 2 0 Nucleotide-sugar transporter DNA_pol_A PF00476.20 CDI78683.1 - 5.8e-67 226.4 0.0 7.4e-51 173.4 0.0 3.4 3 0 0 3 3 3 2 DNA polymerase family A Toprim_2 PF13155.6 CDI78683.1 - 4.5e-07 30.2 0.1 6.5e-06 26.5 0.0 3.2 2 0 0 2 2 2 1 Toprim-like DNA_pol_A_exo1 PF01612.20 CDI78683.1 - 5.5e-06 26.2 0.0 1.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 3'-5' exonuclease Toprim_4 PF13662.6 CDI78683.1 - 0.00098 19.5 0.0 0.0043 17.5 0.0 2.1 2 0 0 2 2 2 1 Toprim domain zf-CHC2 PF01807.20 CDI78683.1 - 0.0081 16.0 0.7 0.024 14.5 0.7 1.7 1 0 0 1 1 1 1 CHC2 zinc finger PQ-loop PF04193.14 CDI78687.1 - 8.1e-05 22.3 0.3 0.00018 21.2 0.3 1.7 1 0 0 1 1 1 1 PQ loop repeat Spt20 PF12090.8 CDI78687.1 - 0.0033 17.1 2.0 0.0042 16.7 2.0 1.1 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI78687.1 - 0.026 13.5 0.4 0.031 13.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI78687.1 - 0.1 12.7 8.6 0.18 11.9 8.6 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Gate PF07670.14 CDI78687.1 - 3.3 8.0 8.5 1.8 8.9 4.0 2.3 2 0 0 2 2 2 0 Nucleoside recognition Spt20 PF12090.8 CDI78688.1 - 0.011 15.4 4.0 0.011 15.4 4.0 5.1 3 1 2 5 5 5 0 Spt20 family FctA PF12892.7 CDI78688.1 - 6.5 7.6 0.0 6.5 7.6 0.0 4.0 4 1 1 5 5 5 0 Spy0128-like isopeptide containing domain Actin PF00022.19 CDI78689.1 - 1.3e-13 50.3 0.1 2.4e-12 46.2 0.1 2.7 1 1 0 1 1 1 1 Actin RskA PF10099.9 CDI78689.1 - 0.0016 18.8 4.5 0.77 10.0 2.3 2.9 3 1 0 3 3 3 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI78689.1 - 0.015 15.4 0.7 0.015 15.4 0.7 4.9 3 2 2 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 SPX PF03105.19 CDI78689.1 - 0.22 11.4 18.5 0.47 10.3 5.2 2.3 2 0 0 2 2 2 0 SPX domain BRF1 PF07741.13 CDI78689.1 - 1.5 9.2 13.2 7.2 7.0 3.0 3.4 3 0 0 3 3 3 0 Brf1-like TBP-binding domain RRF PF01765.19 CDI78690.1 - 1.2e-05 25.3 9.3 0.0011 18.9 0.3 4.9 3 2 1 4 4 4 2 Ribosome recycling factor BRCA2 PF00634.18 CDI78691.1 - 1.2e-27 95.2 1.9 0.0017 18.0 0.1 6.3 6 0 0 6 6 6 6 BRCA2 repeat BRCA-2_OB1 PF09103.10 CDI78691.1 - 5.8e-06 26.3 0.2 0.00032 20.6 0.0 4.1 3 0 0 3 3 3 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 ART-PolyVal PF18760.1 CDI78693.1 - 0.012 16.6 0.7 0.028 15.5 0.7 1.6 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins TRAP_alpha PF03896.16 CDI78693.1 - 0.33 10.1 5.2 0.68 9.1 5.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_pol_3_Rpc31 PF11705.8 CDI78693.1 - 1.3 9.2 10.0 3 8.0 10.0 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.5 CDI78693.1 - 4.9 6.5 12.4 11 5.3 12.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Macoilin PF09726.9 CDI78694.1 - 9.4e-05 21.2 7.4 0.00016 20.4 7.4 1.3 1 0 0 1 1 1 1 Macoilin family SPX PF03105.19 CDI78694.1 - 0.00077 19.5 2.5 0.0011 19.0 2.5 1.4 1 0 0 1 1 1 1 SPX domain Apt1 PF10351.9 CDI78694.1 - 0.036 12.9 6.0 0.053 12.4 6.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI78694.1 - 0.11 11.2 0.6 0.17 10.6 0.6 1.2 1 0 0 1 1 1 0 Presenilin TnsD PF15978.5 CDI78694.1 - 0.17 10.8 0.9 4.8 6.1 0.0 2.1 2 0 0 2 2 2 0 Tn7-like transposition protein D DUF1635 PF07795.11 CDI78694.1 - 1.6 8.5 7.1 3.9 7.3 7.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Miga PF10265.9 CDI78694.1 - 1.8 7.4 9.0 3.3 6.6 9.0 1.4 1 0 0 1 1 1 0 Mitoguardin CCDC106 PF15794.5 CDI78694.1 - 9 5.9 14.9 0.7 9.6 9.7 1.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Nop53 PF07767.11 CDI78695.1 - 0.051 13.0 7.2 0.076 12.4 7.2 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF4872 PF16169.5 CDI78696.1 - 0.026 14.3 0.8 0.41 10.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4872) DUF615 PF04751.14 CDI78697.1 - 0.0019 18.2 2.0 0.0029 17.6 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF615) HetR_C PF18460.1 CDI78697.1 - 0.021 14.7 0.7 0.048 13.6 0.7 1.6 1 1 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain Fib_alpha PF08702.10 CDI78697.1 - 0.29 11.3 1.6 0.47 10.6 1.6 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Strabismus PF06638.11 CDI78698.1 - 0.1 11.2 0.3 0.15 10.7 0.3 1.2 1 0 0 1 1 1 0 Strabismus protein DUF3486 PF11985.8 CDI78698.1 - 1.3 9.5 8.2 3.5 8.0 8.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3486) AF-4 PF05110.13 CDI78700.1 - 0.00027 19.2 21.4 0.00027 19.2 21.4 6.7 2 1 4 6 6 6 1 AF-4 proto-oncoprotein DUF1645 PF07816.11 CDI78700.1 - 0.017 15.7 10.5 0.017 15.7 10.5 7.2 3 1 2 5 5 5 0 Protein of unknown function (DUF1645) SUIM_assoc PF16619.5 CDI78701.1 - 0.00065 19.7 81.3 0.017 15.2 13.9 6.7 6 0 0 6 6 6 5 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI78703.1 - 0.054 13.8 0.0 0.054 13.8 0.0 10.6 2 2 6 8 8 8 0 Anti-sigma-K factor rskA PilN PF05137.13 CDI78703.1 - 0.16 12.1 2.9 0.21 11.8 0.9 2.3 2 1 0 2 2 2 0 Fimbrial assembly protein (PilN) Med3 PF11593.8 CDI78704.1 - 1.3 8.2 4.3 1.5 7.9 4.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SR-25 PF10500.9 CDI78704.1 - 2.5 7.6 12.0 3.3 7.3 12.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ANAPC_CDC26 PF10471.9 CDI78704.1 - 2.9 8.8 9.6 4.7 8.1 9.6 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Activator_LAG-3 PF11498.8 CDI78704.1 - 3.4 6.5 11.6 4.3 6.2 11.6 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI78704.1 - 6.1 6.4 9.6 7.6 6.1 9.6 1.1 1 0 0 1 1 1 0 Spt20 family Med15 PF09606.10 CDI78705.1 - 0.0018 17.1 34.4 0.0018 17.1 34.4 5.3 5 0 0 5 5 5 3 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI78705.1 - 0.0074 16.3 1.0 0.0074 16.3 1.0 6.0 5 1 0 5 5 5 3 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI78707.1 - 0.0015 18.5 7.2 0.0019 18.2 7.2 1.1 1 0 0 1 1 1 1 SPX domain DUF4692 PF15763.5 CDI78707.1 - 0.013 16.0 6.3 0.013 16.0 6.3 2.2 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) RP-C_C PF11800.8 CDI78707.1 - 0.016 15.3 7.9 0.028 14.5 7.9 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Sec3_C PF09763.9 CDI78707.1 - 0.1 11.0 1.2 0.097 11.0 1.2 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Apt1 PF10351.9 CDI78707.1 - 0.24 10.2 11.4 0.35 9.7 11.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 CDI78707.1 - 0.29 11.1 17.4 0.019 14.9 12.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Peptidase_S64 PF08192.11 CDI78707.1 - 1.4 7.3 7.8 1.7 7.0 7.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 ANAPC1 PF12859.7 CDI78707.1 - 7.6 7.1 16.6 3.9 8.0 14.0 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 Miga PF10265.9 CDI78707.1 - 9 5.1 10.0 14 4.5 10.0 1.4 1 0 0 1 1 1 0 Mitoguardin Suf PF05843.14 CDI78709.1 - 0.33 10.9 8.9 0.42 10.6 8.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 CDI78709.1 - 0.66 8.6 8.2 0.68 8.5 8.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TMEM215 PF15746.5 CDI78709.1 - 3.5 7.0 6.1 3.1 7.2 5.0 1.4 1 1 0 1 1 1 0 TMEM215 family PNP_UDP_1 PF01048.20 CDI78710.1 - 4.6e-24 85.0 0.1 5.4e-24 84.7 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Aldedh PF00171.22 CDI78711.1 - 1.7e-135 452.1 3.1 6.5e-122 407.4 1.4 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Peptidase_S58 PF03576.14 CDI78711.1 - 0.013 15.1 0.1 0.025 14.1 0.1 1.5 1 0 0 1 1 1 0 Peptidase family S58 LuxC PF05893.14 CDI78711.1 - 0.03 13.4 1.0 0.073 12.1 1.0 1.5 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) Chlam_vir PF05475.11 CDI78711.1 - 0.096 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Pgp3 C-terminal domain CLAG PF03805.13 CDI78712.1 - 0.00028 18.6 0.2 0.006 14.2 0.2 2.2 1 1 0 1 1 1 1 Cytoadherence-linked asexual protein Adeno_PIX PF03955.14 CDI78712.1 - 0.27 11.4 5.8 0.12 12.6 0.2 3.1 3 0 0 3 3 3 0 Adenovirus hexon-associated protein (IX) NPL PF17800.1 CDI78713.1 - 9.3e-09 35.8 0.0 9.3e-09 35.8 0.0 3.3 2 1 0 2 2 2 1 Nucleoplasmin-like domain Drc1-Sld2 PF11719.8 CDI78713.1 - 0.0092 15.6 36.8 0.012 15.2 36.8 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein Hamartin PF04388.12 CDI78713.1 - 3.6 6.1 13.1 3.7 6.1 13.1 1.1 1 0 0 1 1 1 0 Hamartin protein HA2 PF04408.23 CDI78714.1 - 1.1e-17 64.3 0.1 1.1e-17 64.3 0.1 6.5 6 0 0 6 6 6 1 Helicase associated domain (HA2) DPPIV_N PF00930.21 CDI78714.1 - 9.1e-16 57.5 1.5 1.4e-11 43.8 0.0 3.1 3 0 0 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CDI78714.1 - 2.4e-14 53.3 7.6 3.6e-07 29.9 0.0 3.3 3 0 0 3 3 3 2 Prolyl oligopeptidase family Helicase_C PF00271.31 CDI78714.1 - 1.2e-09 38.5 0.0 4.8e-09 36.6 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CDI78714.1 - 0.00045 20.5 0.5 0.023 15.0 0.0 3.6 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Myc_N PF01056.18 CDI78714.1 - 0.00076 19.5 10.3 0.00076 19.5 10.3 7.4 7 1 1 8 8 8 1 Myc amino-terminal region DUF4667 PF15700.5 CDI78714.1 - 0.0019 18.3 21.2 0.0019 18.3 21.2 10.2 7 3 1 9 9 9 3 Domain of unknown function (DUF4667) DUF2459 PF09601.10 CDI78714.1 - 0.026 14.3 0.5 0.11 12.3 0.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2459) Rep_fac_C PF08542.11 CDI78715.1 - 2.9e-10 40.4 0.0 8.2e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 CDI78715.1 - 0.00024 21.3 0.0 0.00048 20.4 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta2 PF13177.6 CDI78715.1 - 0.0043 16.9 0.5 0.0067 16.2 0.5 1.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.13 CDI78715.1 - 0.0068 16.2 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit FAM117 PF15388.6 CDI78715.1 - 0.015 14.7 3.8 0.02 14.4 3.8 1.2 1 0 0 1 1 1 0 Protein Family FAM117 Macoilin PF09726.9 CDI78715.1 - 0.13 10.8 2.5 0.16 10.5 2.5 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 CDI78715.1 - 2.3 6.4 5.8 2.9 6.1 5.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SprA-related PF12118.8 CDI78715.1 - 5.1 6.1 8.8 7.8 5.5 8.8 1.2 1 0 0 1 1 1 0 SprA-related family Chorein_N PF12624.7 CDI78716.1 - 2.4e-11 43.8 4.5 1.7e-09 37.8 0.0 2.9 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 CDI78716.1 - 1.4e-05 24.6 0.0 5e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 Myb_DNA-binding PF00249.31 CDI78717.1 - 1.6e-16 60.2 12.1 2e-12 47.1 1.1 2.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDI78717.1 - 2.4e-14 53.3 7.0 5.1e-13 49.0 2.5 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 CDI78717.1 - 0.0083 16.2 0.0 0.053 13.6 0.1 2.1 2 1 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_Cef PF11831.8 CDI78718.1 - 1.2e-18 67.5 4.5 1.2e-18 67.5 4.5 2.7 3 0 0 3 3 3 1 pre-mRNA splicing factor component TssC PF17541.2 CDI78718.1 - 0.056 12.3 0.3 0.11 11.3 0.3 1.4 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB DUF2532 PF10811.8 CDI78718.1 - 0.76 9.8 3.4 0.22 11.5 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2532) Kazal_1 PF00050.21 CDI78719.1 - 1.3e-21 76.3 36.6 2.2e-07 30.8 0.1 4.7 2 1 2 4 4 4 4 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 CDI78719.1 - 2.5e-19 69.1 44.3 7.1e-07 29.3 1.0 4.8 4 1 0 4 4 4 4 Kazal-type serine protease inhibitor domain Gamma-thionin PF00304.20 CDI78719.1 - 5.4 7.4 46.5 1.6 9.1 4.7 5.1 3 2 2 5 5 5 0 Gamma-thionin family Got1 PF04178.12 CDI78720.1 - 1.9e-31 108.8 20.0 2.7e-31 108.3 20.0 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family Lectin_leg-like PF03388.13 CDI78721.1 - 2.2e-12 46.8 0.3 7.8e-12 45.0 0.3 1.8 1 1 0 1 1 1 1 Legume-like lectin family Asn_synthase PF00733.21 CDI78722.1 - 2.2e-13 50.6 8.7 1.9e-05 24.5 0.1 3.2 2 1 1 3 3 3 3 Asparagine synthase NAD_synthase PF02540.17 CDI78722.1 - 0.23 10.5 0.4 0.35 9.9 0.4 1.2 1 0 0 1 1 1 0 NAD synthase AAA_12 PF13087.6 CDI78725.1 - 1.9e-36 125.6 0.0 1.1e-28 100.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDI78725.1 - 6e-08 32.6 0.2 5.4e-07 29.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CDI78725.1 - 6.3e-07 29.5 0.0 0.023 14.5 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 CDI78725.1 - 7.1e-05 23.2 0.0 0.00023 21.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDI78725.1 - 0.0007 19.4 0.0 1.2 8.8 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 CDI78725.1 - 0.027 14.9 0.1 0.027 14.9 0.1 3.3 4 2 0 4 4 4 0 AAA ATPase domain AAA_2 PF07724.14 CDI78726.1 - 3.7e-51 173.6 0.0 9.5e-50 169.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDI78726.1 - 2.1e-33 114.3 0.6 2.1e-33 114.3 0.6 2.7 3 0 0 3 3 2 1 AAA lid domain ClpB_D2-small PF10431.9 CDI78726.1 - 6.2e-20 71.1 1.1 2.5e-19 69.1 0.2 2.6 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDI78726.1 - 1.7e-19 70.5 0.0 8.6e-10 39.1 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Clp_N PF02861.20 CDI78726.1 - 1.3e-16 60.4 0.7 5.5e-09 36.0 0.2 3.5 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_5 PF07728.14 CDI78726.1 - 7.8e-12 45.4 0.0 2.3e-10 40.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDI78726.1 - 9.1e-07 28.7 0.0 8.4e-06 25.6 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 CDI78726.1 - 1.1e-05 25.5 0.0 0.042 13.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 CDI78726.1 - 9.1e-05 22.5 0.0 0.4 10.5 0.0 3.1 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea RuvB_N PF05496.12 CDI78726.1 - 9.6e-05 22.2 0.1 0.051 13.3 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDI78726.1 - 0.00012 22.3 1.9 0.0049 17.2 0.0 3.8 4 0 0 4 4 3 1 AAA domain AAA_7 PF12775.7 CDI78726.1 - 0.00089 18.8 0.0 0.0074 15.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region DNA_pol3_delta2 PF13177.6 CDI78726.1 - 0.0023 17.7 0.0 1.9 8.3 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase III, delta subunit AAA_18 PF13238.6 CDI78726.1 - 0.0034 17.9 0.4 0.027 15.0 0.0 2.7 2 1 1 3 3 3 1 AAA domain Zeta_toxin PF06414.12 CDI78726.1 - 0.0069 15.7 0.1 0.036 13.4 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.21 CDI78726.1 - 0.0078 15.6 0.2 2.3 7.5 0.0 3.2 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CDI78726.1 - 0.019 15.4 0.3 0.019 15.4 0.3 5.0 4 3 1 5 5 3 0 AAA ATPase domain T2SSE PF00437.20 CDI78726.1 - 0.021 13.9 0.0 0.052 12.6 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein Sulfatase_C PF14707.6 CDI78726.1 - 0.027 15.2 0.1 0.074 13.8 0.1 1.8 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase AAA_3 PF07726.11 CDI78726.1 - 0.044 13.6 0.0 0.37 10.7 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CDI78726.1 - 0.045 13.5 0.0 0.17 11.6 0.0 2.0 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 CDI78726.1 - 0.05 14.1 0.1 0.23 11.9 0.0 2.1 2 0 0 2 2 1 0 ABC transporter RsgA_GTPase PF03193.16 CDI78726.1 - 0.057 13.3 0.1 1.3 8.9 0.0 3.0 3 1 0 3 3 3 0 RsgA GTPase AAA_30 PF13604.6 CDI78726.1 - 0.062 13.0 0.0 0.33 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CDI78726.1 - 0.27 11.3 2.5 1.2 9.2 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain phage_tail_N PF08400.10 CDI78726.1 - 0.45 10.5 1.3 1.4 8.9 0.2 2.4 3 0 0 3 3 2 0 Prophage tail fibre N-terminal Fmp27_WPPW PF10359.9 CDI78726.1 - 0.74 8.6 4.5 1.2 7.9 4.5 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain EcoEI_R_C PF08463.10 CDI78726.1 - 2.1 8.5 9.5 1 9.5 2.5 3.3 3 0 0 3 3 3 0 EcoEI R protein C-terminal AAA_23 PF13476.6 CDI78726.1 - 9.6 6.7 0.0 9.6 6.7 0.0 3.0 2 1 0 2 2 1 0 AAA domain Coatomer_WDAD PF04053.14 CDI78727.1 - 6.2e-74 249.6 0.0 1.4e-73 248.5 0.0 1.6 1 1 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 CDI78727.1 - 4.2e-50 170.7 0.0 7.2e-50 169.9 0.0 1.3 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CDI78727.1 - 9.8e-38 127.5 18.4 2.3e-07 31.4 0.5 7.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78727.1 - 1.1e-12 48.0 0.0 4.4e-07 30.1 0.0 4.9 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain NRBF2_MIT PF17169.4 CDI78727.1 - 0.0086 16.3 0.5 0.023 14.9 0.5 1.6 1 0 0 1 1 1 1 MIT domain of nuclear receptor-binding factor 2 TPR_2 PF07719.17 CDI78727.1 - 0.01 15.9 2.5 5 7.5 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Nup160 PF11715.8 CDI78727.1 - 0.042 12.5 9.3 2.3 6.8 0.1 3.8 2 1 1 4 4 4 0 Nucleoporin Nup120/160 TPR_14 PF13428.6 CDI78727.1 - 2.3 9.2 8.3 51 5.1 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Efg1 PF10153.9 CDI78728.1 - 5.5e-06 26.7 16.0 1.3e-05 25.5 15.8 1.7 1 1 0 1 1 1 1 rRNA-processing protein Efg1 DUF1116 PF06545.11 CDI78728.1 - 0.05 13.1 0.1 0.11 12.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1116) DUF5401 PF17380.2 CDI78728.1 - 0.061 11.4 15.5 0.079 11.0 15.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Polysacc_deac_1 PF01522.21 CDI78728.1 - 0.54 10.2 3.0 0.44 10.5 1.2 1.6 2 0 0 2 2 2 0 Polysaccharide deacetylase Maf PF02545.14 CDI78729.1 - 3.4e-21 75.8 0.0 1.7e-10 41.0 0.0 2.8 2 1 0 2 2 2 2 Maf-like protein Zn-ribbon_8 PF09723.10 CDI78729.1 - 1.1 9.4 3.8 2.7 8.2 3.8 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DSPc PF00782.20 CDI78730.1 - 2.3e-06 27.5 0.0 4.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDI78730.1 - 0.0019 17.8 0.0 0.0049 16.5 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Glyco_trans_4_4 PF13579.6 CDI78730.1 - 0.034 14.6 2.1 0.086 13.3 2.1 1.7 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain NOC3p PF07540.11 CDI78732.1 - 4.2e-10 39.9 0.6 4.2e-10 39.9 0.6 4.0 5 0 0 5 5 5 1 Nucleolar complex-associated protein TFIIF_alpha PF05793.12 CDI78732.1 - 1.3 7.6 31.3 2.3 6.7 14.6 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Arm PF00514.23 CDI78733.1 - 3.8e-10 39.5 43.1 1.4e-05 25.0 1.0 8.2 8 0 0 8 8 8 5 Armadillo/beta-catenin-like repeat PRKCSH-like PF12999.7 CDI78734.1 - 0.13 12.1 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Cyclin PF08613.11 CDI78735.1 - 2.6e-08 34.4 31.4 2.6e-08 34.4 31.4 10.0 7 3 0 7 7 7 1 Cyclin Cwf_Cwc_15 PF04889.12 CDI78735.1 - 0.00086 19.1 32.3 0.00086 19.1 32.3 6.5 4 3 0 6 6 6 1 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 CDI78735.1 - 0.0024 17.5 8.8 0.0024 17.5 8.8 12.1 6 3 5 12 12 12 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI78736.1 - 0.0022 18.3 5.0 0.0022 18.3 5.0 40.9 9 6 19 29 29 29 7 Anti-sigma-K factor rskA DUF1418 PF07214.12 CDI78736.1 - 0.02 14.7 1.4 0.69 9.8 0.2 4.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) SNARE PF05739.19 CDI78736.1 - 0.062 13.3 0.2 0.35 10.9 0.2 2.4 1 0 0 1 1 1 0 SNARE domain Snf7 PF03357.21 CDI78737.1 - 6.4e-12 45.4 18.0 6.4e-12 45.4 18.0 2.9 2 1 1 3 3 3 1 Snf7 ADK PF00406.22 CDI78738.1 - 1.1e-19 71.1 0.0 2.6e-19 69.8 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDI78738.1 - 1.5e-16 61.0 0.1 1.9e-14 54.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain SUIM_assoc PF16619.5 CDI78738.1 - 0.00018 21.5 0.0 0.00018 21.5 0.0 5.1 4 2 1 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI78738.1 - 0.0012 18.9 14.7 0.0012 18.9 14.7 2.5 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Rad9 PF04139.13 CDI78738.1 - 0.011 15.1 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Rad9 Spore_YhcN_YlaJ PF09580.10 CDI78738.1 - 0.65 10.1 12.0 1.5 8.9 7.1 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF755 PF05501.11 CDI78740.1 - 0.0054 17.0 27.6 0.0054 17.0 27.6 6.6 6 1 0 6 6 6 1 Domain of unknown function (DUF755) LCD1 PF09798.9 CDI78740.1 - 0.006 15.2 2.8 0.083 11.4 2.8 2.3 1 1 0 1 1 1 1 DNA damage checkpoint protein AAA_23 PF13476.6 CDI78740.1 - 0.012 16.2 11.9 0.043 14.3 9.2 2.5 2 0 0 2 2 2 0 AAA domain RskA PF10099.9 CDI78740.1 - 0.35 11.1 48.6 0.37 11.1 13.8 4.2 3 1 0 4 4 4 0 Anti-sigma-K factor rskA Eapp_C PF10238.9 CDI78741.1 - 4.1e-08 33.4 7.2 4.1e-08 33.4 7.2 4.0 2 2 1 3 3 3 1 E2F-associated phosphoprotein Yippee-Mis18 PF03226.14 CDI78741.1 - 3.7 7.8 12.2 81 3.5 12.2 2.5 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LUC7 PF03194.15 CDI78741.1 - 4 7.0 29.8 0.19 11.4 23.8 1.8 2 0 0 2 2 2 0 LUC7 N_terminus SID-1_RNA_chan PF13965.6 CDI78742.1 - 0.013 13.9 26.7 0.024 13.1 6.0 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Hamartin PF04388.12 CDI78742.1 - 0.27 9.9 50.8 0.38 9.4 50.8 1.3 1 0 0 1 1 1 0 Hamartin protein DUF4776 PF16003.5 CDI78742.1 - 7.5 5.4 49.2 0.086 11.8 20.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) DEAD PF00270.29 CDI78743.1 - 1e-10 41.6 0.0 1.4e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2722 PF10846.8 CDI78744.1 - 0.0014 17.7 2.6 0.0016 17.5 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) UPF0560 PF10577.9 CDI78744.1 - 1.7 7.1 6.3 2.1 6.7 6.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 BRF1 PF07741.13 CDI78744.1 - 2.3 8.6 6.7 4.9 7.5 2.0 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Mpp10 PF04006.12 CDI78744.1 - 4.5 5.6 9.5 0.5 8.7 0.8 2.0 2 0 0 2 2 2 0 Mpp10 protein Ribosomal_60s PF00428.19 CDI78744.1 - 5.4 7.7 9.6 12 6.6 1.7 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein RBM39linker PF15519.6 CDI78744.1 - 9.6 7.4 8.6 4.4 8.5 3.2 2.6 3 0 0 3 3 3 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF4551 PF15087.6 CDI78745.1 - 2.6 6.8 27.7 4 6.1 27.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) PBP PF01161.20 CDI78746.1 - 0.00016 22.0 0.0 0.00027 21.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ecm29 PF13001.7 CDI78747.1 - 1.7e-09 36.9 4.9 0.0015 17.3 0.0 3.5 3 0 0 3 3 3 2 Proteasome stabiliser HEAT PF02985.22 CDI78747.1 - 0.028 14.7 18.8 0.09 13.1 0.0 6.9 6 0 0 6 6 6 0 HEAT repeat Cohesin_HEAT PF12765.7 CDI78747.1 - 0.063 13.6 0.1 0.19 12.1 0.1 1.8 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion Vac14_Fab1_bd PF12755.7 CDI78747.1 - 0.13 12.9 0.0 3.2 8.4 0.0 2.5 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CDI78747.1 - 0.43 11.1 0.0 0.43 11.1 0.0 9.6 10 0 0 10 10 10 0 HEAT-like repeat DTW PF03942.15 CDI78748.1 - 2.1e-21 76.6 8.2 1.6e-20 73.7 8.2 2.2 1 1 0 1 1 1 1 DTW domain Presenilin PF01080.17 CDI78748.1 - 0.28 9.9 10.5 0.51 9.0 2.0 2.1 2 0 0 2 2 2 0 Presenilin PT-VENN PF04829.13 CDI78748.1 - 0.37 10.9 7.9 0.21 11.7 2.8 2.5 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif DUF4512 PF14975.6 CDI78748.1 - 0.44 11.4 0.1 0.44 11.4 0.1 2.9 2 2 2 4 4 4 0 Domain of unknown function (DUF4512) Suf PF05843.14 CDI78748.1 - 0.99 9.3 13.2 1.2 9.0 5.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Lin-8 PF03353.15 CDI78748.1 - 4.6 6.7 9.7 7.4 6.0 0.8 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MDM10 PF12519.8 CDI78748.1 - 5 5.9 4.7 2.3 7.0 0.3 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 DUF21 PF01595.20 CDI78749.1 - 0.021 14.6 1.8 0.031 14.0 0.5 1.8 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain DUF2721 PF11026.8 CDI78749.1 - 0.03 14.2 0.9 0.058 13.3 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF1700 PF08006.11 CDI78749.1 - 0.077 12.5 0.3 0.11 12.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) TcpE PF12648.7 CDI78749.1 - 0.077 13.5 0.4 0.15 12.6 0.4 1.5 1 0 0 1 1 1 0 TcpE family UPF0016 PF01169.19 CDI78749.1 - 0.44 10.9 6.6 1.1 9.7 6.3 1.9 1 1 0 1 1 1 0 Uncharacterized protein family UPF0016 Phostensin_N PF13916.6 CDI78750.1 - 0.026 14.9 0.2 0.026 14.9 0.2 1.8 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal AF-4 PF05110.13 CDI78754.1 - 0.0027 15.9 10.3 0.0027 15.9 10.3 2.4 2 1 0 2 2 2 1 AF-4 proto-oncoprotein DUF3684 PF12449.8 CDI78754.1 - 0.035 11.9 1.4 0.077 10.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3684) TFIIA PF03153.13 CDI78754.1 - 0.21 11.6 24.9 0.13 12.3 11.9 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI78754.1 - 0.39 10.6 15.0 1.7 8.5 14.8 2.1 1 1 0 1 1 1 0 SPX domain Fungal_trans PF04082.18 CDI78754.1 - 0.65 9.0 4.6 2.4 7.1 4.6 2.1 1 1 0 1 1 1 0 Fungal specific transcription factor domain Spt20 PF12090.8 CDI78754.1 - 1.1 8.9 27.6 2.8 7.5 6.2 2.4 2 0 0 2 2 2 0 Spt20 family FAM176 PF14851.6 CDI78754.1 - 2.4 7.8 9.0 2 8.0 0.3 2.9 3 0 0 3 3 3 0 FAM176 family DUF4366 PF14283.6 CDI78754.1 - 3.7 7.6 13.5 0.15 12.1 1.3 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4366) Sec62 PF03839.16 CDI78754.1 - 6.8 6.1 7.1 3.2 7.2 1.8 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 RRM_1 PF00076.22 CDI78755.1 - 1.9e-08 34.0 0.0 3.7e-07 29.9 0.0 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CDI78755.1 - 0.0082 17.0 0.1 57 4.8 0.0 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat Glyoxalase_5 PF14696.6 CDI78755.1 - 0.22 11.7 1.1 0.57 10.4 0.1 2.2 2 0 0 2 2 2 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal G-patch PF01585.23 CDI78756.1 - 0.006 16.4 1.1 0.014 15.3 1.1 1.7 1 0 0 1 1 1 1 G-patch domain IMUP PF15761.5 CDI78756.1 - 0.017 15.8 0.4 0.017 15.8 0.4 7.9 7 1 1 8 8 8 0 Immortalisation up-regulated protein zf_CCCH_4 PF18345.1 CDI78756.1 - 0.038 14.1 0.6 0.085 12.9 0.6 1.7 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 CDI78756.1 - 0.098 12.6 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Cons_hypoth95 PF03602.15 CDI78757.1 - 2.2e-05 24.2 0.2 4.5e-05 23.2 0.2 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 CDI78757.1 - 3.3e-05 23.4 0.0 7.1e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CDI78757.1 - 0.00013 21.5 0.0 0.00029 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDI78757.1 - 0.00056 20.6 0.0 0.0023 18.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI78757.1 - 0.0086 15.9 0.2 0.016 15.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI78757.1 - 0.026 14.3 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 CDI78757.1 - 0.029 14.2 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 CDI78757.1 - 0.049 13.4 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_9 PF08003.11 CDI78757.1 - 0.087 11.7 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 CDI78757.1 - 0.13 13.0 0.0 0.34 11.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 CDI78757.1 - 0.14 11.6 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 AAA_12 PF13087.6 CDI78758.1 - 4.5e-40 137.4 0.0 4.5e-40 137.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain Chorion_2 PF03964.15 CDI78758.1 - 3.7 8.4 10.6 11 6.9 1.8 2.5 2 1 0 2 2 2 0 Chorion family 2 IMUP PF15761.5 CDI78758.1 - 4.3 8.1 11.2 0.09 13.5 2.0 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein Presenilin PF01080.17 CDI78758.1 - 8 5.1 6.3 12 4.5 6.3 1.3 1 0 0 1 1 1 0 Presenilin DAG_kinase_N PF14513.6 CDI78759.1 - 1.6 8.9 28.3 2.2 8.5 28.3 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Presenilin PF01080.17 CDI78759.1 - 2.7 6.7 41.9 2.7 6.7 41.9 1.0 1 0 0 1 1 1 0 Presenilin FGF-BP1 PF06473.12 CDI78759.1 - 3.6 7.4 37.4 6.2 6.6 37.4 1.4 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) ALMT PF11744.8 CDI78759.1 - 4.3 6.1 31.8 4.8 5.9 31.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 CDI78759.1 - 5.1 6.0 26.4 5.7 5.9 26.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein CCSAP PF15748.5 CDI78760.1 - 0.035 14.3 40.7 0.039 14.1 40.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Presenilin PF01080.17 CDI78760.1 - 0.11 11.3 37.0 0.13 11.0 37.0 1.1 1 0 0 1 1 1 0 Presenilin TP53IP5 PF15331.6 CDI78760.1 - 0.51 10.4 26.0 0.56 10.3 26.0 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Raftlin PF15250.6 CDI78760.1 - 0.66 8.6 27.4 0.72 8.5 27.4 1.0 1 0 0 1 1 1 0 Raftlin Dapper PF15268.6 CDI78760.1 - 3.3 6.5 41.3 3.5 6.4 41.3 1.0 1 0 0 1 1 1 0 Dapper RIFIN PF02009.16 CDI78760.1 - 7.6 6.3 18.0 8.8 6.1 18.0 1.1 1 0 0 1 1 1 0 Rifin XRN_M PF17846.1 CDI78760.1 - 8 5.3 21.7 9.4 5.1 21.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain VIR_N PF15912.5 CDI78760.1 - 8.1 6.0 20.0 12 5.4 20.0 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal UPF1_Zn_bind PF09416.10 CDI78761.1 - 9.3e-48 162.1 1.7 9.3e-48 162.1 1.7 2.7 2 1 1 3 3 3 1 RNA helicase (UPF2 interacting domain) SR-25 PF10500.9 CDI78761.1 - 0.0043 16.7 25.9 0.0043 16.7 25.9 3.5 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein PI3K_1B_p101 PF10486.9 CDI78761.1 - 0.91 7.2 25.8 1.6 6.4 25.8 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit AAA_23 PF13476.6 CDI78761.1 - 9 6.7 24.3 20 5.6 24.3 1.5 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 CDI78762.1 - 0.47 9.2 44.7 0.56 8.9 44.7 1.0 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 CDI78762.1 - 0.62 10.0 30.1 0.74 9.8 30.1 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF2052 PF09747.9 CDI78762.1 - 1.4 9.0 39.1 1.7 8.8 39.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Vfa1 PF08432.10 CDI78762.1 - 1.5 9.1 38.7 1.8 8.9 38.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 CDI78762.1 - 3.3 6.6 38.8 3.8 6.4 38.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 CDI78762.1 - 3.7 7.3 42.6 4.7 6.9 42.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3292 PF11696.8 CDI78762.1 - 4 5.7 25.5 5.4 5.3 25.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Raftlin PF15250.6 CDI78762.1 - 4.1 6.0 29.9 4.5 5.9 29.9 1.0 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.14 CDI78762.1 - 4.6 5.4 38.6 5.3 5.2 38.6 1.0 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 CDI78762.1 - 5.1 5.4 35.0 5.5 5.3 35.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF4045 PF13254.6 CDI78762.1 - 5.5 6.5 34.5 6.3 6.3 34.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Asp-B-Hydro_N PF05279.11 CDI78762.1 - 5.8 6.9 33.2 6.8 6.7 33.2 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Smg8_Smg9 PF10220.9 CDI78762.1 - 6.4 4.9 33.6 7.1 4.8 33.6 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Endostatin PF06482.11 CDI78762.1 - 6.4 6.1 34.9 8.7 5.7 34.9 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin PA26 PF04636.13 CDI78762.1 - 6.9 5.5 27.6 8.1 5.2 27.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Rtf2 PF04641.12 CDI78762.1 - 7 5.9 34.0 9.2 5.5 34.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger CCSAP PF15748.5 CDI78762.1 - 8.5 6.5 45.6 9.7 6.3 45.6 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Hid1 PF12722.7 CDI78762.1 - 8.5 4.4 35.9 9.6 4.2 35.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TSP_1 PF00090.19 CDI78763.1 - 6e-71 234.5 210.9 8.8e-13 48.3 3.4 17.6 18 1 0 18 18 18 13 Thrombospondin type 1 domain Notch PF00066.17 CDI78763.1 - 1.4e-09 38.3 49.5 6.6e-07 29.7 13.1 6.4 4 0 0 4 4 4 2 LNR domain ShK PF01549.24 CDI78763.1 - 0.44 11.1 74.6 0.066 13.8 0.5 13.6 11 0 0 11 11 11 0 ShK domain-like Arf PF00025.21 CDI78764.1 - 9.9e-19 67.4 0.0 7.5e-18 64.6 0.0 2.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDI78764.1 - 7.5e-07 29.4 0.0 1.7e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDI78764.1 - 3.4e-05 23.2 0.6 0.11 11.6 0.4 2.5 2 0 0 2 2 2 2 G-protein alpha subunit AAA_16 PF13191.6 CDI78764.1 - 0.00086 19.7 1.2 0.00086 19.7 1.2 3.1 1 1 1 2 2 2 1 AAA ATPase domain SRPRB PF09439.10 CDI78764.1 - 0.043 13.2 0.0 0.22 10.9 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Ras PF00071.22 CDI78764.1 - 0.045 13.3 0.1 0.21 11.2 0.1 1.9 1 1 0 1 1 1 0 Ras family AAA_18 PF13238.6 CDI78764.1 - 0.054 14.1 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDI78764.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 CDI78764.1 - 0.8 9.9 4.6 1.8 8.7 0.1 2.6 2 1 0 2 2 2 0 AAA domain YL1 PF05764.13 CDI78765.1 - 0.87 9.7 27.6 0.97 9.5 27.6 1.0 1 0 0 1 1 1 0 YL1 nuclear protein Sporozoite_P67 PF05642.11 CDI78765.1 - 1.9 6.5 16.9 2 6.4 16.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Merozoite_SPAM PF07133.11 CDI78765.1 - 2.8 7.9 25.7 2.9 7.9 25.7 1.0 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) TEX19 PF15553.6 CDI78765.1 - 4.4 7.2 10.7 4.7 7.1 10.7 1.2 1 0 0 1 1 1 0 Testis-expressed protein 19 Spt20 PF12090.8 CDI78765.1 - 4.9 6.7 12.8 5.5 6.5 12.8 1.0 1 0 0 1 1 1 0 Spt20 family Mpp10 PF04006.12 CDI78765.1 - 5.8 5.2 23.9 5.9 5.2 23.9 1.0 1 0 0 1 1 1 0 Mpp10 protein SDA1 PF05285.12 CDI78765.1 - 6.7 6.0 25.6 7.3 5.9 25.6 1.0 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 CDI78765.1 - 6.7 5.7 29.1 7.4 5.6 29.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Trypan_PARP PF05887.11 CDI78765.1 - 7.3 6.6 13.4 8.2 6.4 13.4 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.14 CDI78765.1 - 8.6 4.5 22.6 8.6 4.5 22.6 1.0 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.13 CDI78768.1 - 2.3e-07 31.2 75.8 0.00026 21.1 48.9 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI78768.1 - 1.4e-06 27.6 6.1 1.4e-06 27.6 6.1 3.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) SAGA-Tad1 PF12767.7 CDI78768.1 - 0.053 13.3 26.0 0.5 10.1 19.3 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Gti1_Pac2 PF09729.9 CDI78768.1 - 0.12 12.4 27.8 0.6 10.2 0.0 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family DUF4045 PF13254.6 CDI78768.1 - 0.82 9.3 29.8 1.8 8.1 20.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Neur_chan_memb PF02932.16 CDI78768.1 - 1.4 8.9 28.8 0.19 11.8 14.9 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3807 PF12720.7 CDI78768.1 - 1.7 8.9 50.7 0.026 14.8 27.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) RR_TM4-6 PF06459.12 CDI78768.1 - 2.3 8.0 42.2 0.062 13.1 23.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI78768.1 - 2.5 6.3 61.9 0.086 11.1 36.2 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Zip PF02535.22 CDI78768.1 - 6.7 5.8 22.6 16 4.6 0.2 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter tRNA-synt_2d PF01409.20 CDI78769.1 - 1.9e-22 80.0 0.0 1.8e-15 57.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Otopetrin PF03189.13 CDI78769.1 - 0.013 14.3 0.1 0.013 14.3 0.1 2.5 2 1 0 2 2 1 0 Otopetrin DUF572 PF04502.13 CDI78769.1 - 0.015 14.9 36.7 0.01 15.5 9.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) ABC2_membrane_2 PF12679.7 CDI78769.1 - 0.042 13.1 6.1 1.8 7.8 0.3 3.6 2 1 0 2 2 2 0 ABC-2 family transporter protein Mem_trans PF03547.18 CDI78769.1 - 0.46 8.8 0.0 0.46 8.8 0.0 2.6 3 0 0 3 3 2 0 Membrane transport protein AAA_11 PF13086.6 CDI78769.1 - 0.6 9.8 35.9 0.94 9.2 6.1 2.3 2 0 0 2 2 2 0 AAA domain DUF2052 PF09747.9 CDI78769.1 - 0.64 10.1 44.0 0.56 10.3 7.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RskA PF10099.9 CDI78769.1 - 0.85 9.9 83.5 0.17 12.1 4.1 5.5 2 1 1 4 4 2 0 Anti-sigma-K factor rskA SPX PF03105.19 CDI78769.1 - 1.3 8.9 34.3 1.7 8.5 10.5 2.3 2 0 0 2 2 2 0 SPX domain TT_ORF1 PF02956.14 CDI78769.1 - 1.8 7.1 28.1 2.3 6.8 11.7 2.1 2 0 0 2 2 2 0 TT viral orf 1 NPR3 PF03666.13 CDI78769.1 - 3.2 6.4 37.8 0.57 8.9 5.6 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SAGA-Tad1 PF12767.7 CDI78769.1 - 3.5 7.3 30.8 1.5 8.5 14.4 2.5 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit SpoIIIAH PF12685.7 CDI78769.1 - 3.7 7.3 35.6 0.91 9.3 16.2 2.5 2 1 0 2 2 2 0 SpoIIIAH-like protein DUF2151 PF10221.9 CDI78769.1 - 4.9 5.6 24.6 3.3 6.2 12.9 2.1 2 0 0 2 2 2 0 Cell cycle and development regulator CNDH2_C PF16858.5 CDI78769.1 - 5.4 6.8 39.3 5 6.9 9.9 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term IMUP PF15761.5 CDI78771.1 - 0.03 15.0 5.2 0.03 15.0 5.2 2.7 2 1 1 3 3 3 0 Immortalisation up-regulated protein SbcCD_C PF13558.6 CDI78771.1 - 1.5 9.1 8.3 0.12 12.6 0.7 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Med15 PF09606.10 CDI78771.1 - 2.9 6.5 65.9 3.4 6.2 65.9 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal VIR_N PF15912.5 CDI78771.1 - 7.8 6.0 23.1 0.043 13.4 5.4 2.4 3 0 0 3 3 3 0 Virilizer, N-terminal FabA PF07977.13 CDI78772.1 - 9.5e-14 51.2 0.0 1.1e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydrat_N PF13452.6 CDI78772.1 - 0.025 14.7 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase Cytochrom_C_asm PF01578.20 CDI78773.1 - 1.2 8.9 6.3 0.35 10.6 2.9 1.8 2 0 0 2 2 2 0 Cytochrome C assembly protein Ribosomal_60s PF00428.19 CDI78773.1 - 2.3 8.8 7.5 0.35 11.5 1.2 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein DEAD PF00270.29 CDI78774.1 - 1.6e-15 57.3 1.2 5.9e-10 39.2 0.0 3.4 2 1 1 3 3 3 2 DEAD/DEAH box helicase Sec63 PF02889.16 CDI78774.1 - 5.7e-09 35.5 0.2 1.2e-08 34.4 0.2 1.5 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 CDI78774.1 - 1e-08 35.5 0.0 5.2e-08 33.2 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI78774.1 - 2.2e-05 24.5 0.2 9.8e-05 22.4 0.0 2.1 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDI78774.1 - 3.3e-05 24.2 0.0 0.011 16.0 0.0 2.9 1 1 0 2 2 2 1 AAA domain Macoilin PF09726.9 CDI78774.1 - 0.5 8.9 22.6 0.8 8.2 22.6 1.3 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 CDI78774.1 - 5.6 6.5 39.1 0.51 9.9 22.3 2.5 2 0 0 2 2 2 0 Spt20 family Pkinase PF00069.25 CDI78775.1 - 6e-47 160.2 0.0 7.9e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78775.1 - 1.8e-19 70.1 0.0 1.6e-18 67.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDI78775.1 - 0.017 14.0 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CDI78775.1 - 0.019 14.3 0.1 0.039 13.3 0.0 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDI78775.1 - 0.038 12.8 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 CDI78776.1 - 0.00015 21.3 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SUIM_assoc PF16619.5 CDI78778.1 - 0.015 15.3 2.2 0.015 15.3 2.2 3.8 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2973 PF11189.8 CDI78778.1 - 0.61 10.2 0.0 0.61 10.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2973) Piezo_RRas_bdg PF12166.8 CDI78778.1 - 1.6 7.9 4.3 7.6 5.7 0.1 2.1 2 0 0 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain WDCP PF15390.6 CDI78778.1 - 1.6 7.0 7.9 0.69 8.2 5.5 1.4 1 1 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Nop14 PF04147.12 CDI78779.1 - 0.11 10.7 16.6 0.13 10.5 16.6 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 CDI78779.1 - 0.12 11.6 14.7 0.14 11.4 14.7 1.0 1 0 0 1 1 1 0 BUD22 PTPRCAP PF15713.5 CDI78779.1 - 0.26 11.6 16.5 0.32 11.3 16.5 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4307 PF14155.6 CDI78779.1 - 0.27 11.1 3.1 0.33 10.8 2.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) TRAP_alpha PF03896.16 CDI78779.1 - 0.34 10.1 8.1 0.51 9.5 8.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Mem_trans PF03547.18 CDI78779.1 - 0.47 8.8 2.8 0.6 8.4 2.8 1.1 1 0 0 1 1 1 0 Membrane transport protein RPN2_C PF18004.1 CDI78779.1 - 1.6 8.6 8.9 2.4 8.0 8.9 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 CDI78779.1 - 1.9 8.2 10.7 2.8 7.6 10.7 1.4 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.12 CDI78779.1 - 2.6 7.4 18.6 3.2 7.1 18.6 1.1 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 CDI78779.1 - 3.4 7.9 17.2 4.7 7.4 17.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Presenilin PF01080.17 CDI78779.1 - 3.5 6.3 6.0 4.1 6.1 6.0 1.1 1 0 0 1 1 1 0 Presenilin Myosin_head PF00063.21 CDI78780.1 - 1.8e-74 251.2 0.0 3.5e-52 177.6 0.0 2.5 2 1 1 3 3 3 2 Myosin head (motor domain) AAA_16 PF13191.6 CDI78780.1 - 0.00061 20.2 0.0 0.0012 19.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 CDI78780.1 - 0.011 15.0 0.1 0.02 14.2 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 CDI78780.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 CDI78780.1 - 0.013 16.0 0.0 0.019 15.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Septin PF00735.18 CDI78780.1 - 0.026 13.8 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Septin TsaE PF02367.17 CDI78780.1 - 0.027 14.4 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDI78780.1 - 0.063 13.7 0.0 0.14 12.5 0.0 1.7 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 CDI78780.1 - 0.14 11.9 0.3 0.25 11.0 0.3 1.4 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 CDI78781.1 - 5.1e-06 26.0 6.5 6.9e-06 25.6 6.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) FKBP_N PF01346.18 CDI78781.1 - 0.035 15.1 5.3 0.035 15.1 5.3 1.7 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase TFIIA PF03153.13 CDI78781.1 - 0.27 11.2 10.0 0.3 11.0 10.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5336 PF17270.2 CDI78781.1 - 0.77 9.4 3.9 11 5.6 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5336) Orf78 PF06024.12 CDI78781.1 - 0.97 9.8 5.7 1.1 9.6 0.2 2.3 2 0 0 2 2 2 0 Orf78 (ac78) DUF3675 PF12428.8 CDI78781.1 - 1.3 9.6 4.6 7.9 7.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) DUF2208 PF09973.9 CDI78781.1 - 2.4 7.7 5.3 2.9 7.5 1.9 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Ferlin_C PF16165.5 CDI78781.1 - 2.5 8.0 8.8 3.9 7.4 0.2 2.3 1 1 0 2 2 2 0 Ferlin C-terminus MTS PF05175.14 CDI78783.1 - 6.2e-07 29.1 0.0 0.48 10.0 0.0 3.1 3 0 0 3 3 3 3 Methyltransferase small domain Methyltransf_25 PF13649.6 CDI78783.1 - 0.022 15.5 0.0 0.81 10.4 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain Cons_hypoth95 PF03602.15 CDI78783.1 - 0.024 14.3 0.0 0.1 12.2 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical protein 95 TehB PF03848.14 CDI78783.1 - 0.24 10.8 0.0 0.37 10.2 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Sin_N PF04801.13 CDI78786.1 - 0.00044 19.6 17.6 0.00095 18.5 17.7 1.3 1 1 0 1 1 1 1 Sin-like protein conserved region SPX PF03105.19 CDI78786.1 - 0.0031 17.5 13.6 0.0049 16.9 13.6 1.2 1 0 0 1 1 1 1 SPX domain Spore_coat_CotO PF14153.6 CDI78786.1 - 0.0055 16.7 10.7 0.0055 16.7 10.7 2.2 2 0 0 2 2 2 1 Spore coat protein CotO Kei1 PF08552.11 CDI78786.1 - 0.008 16.1 0.2 0.008 16.1 0.2 2.7 3 0 0 3 3 3 1 Inositolphosphorylceramide synthase subunit Kei1 Neur_chan_memb PF02932.16 CDI78786.1 - 0.011 15.9 0.7 0.011 15.9 0.7 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region AUX_IAA PF02309.16 CDI78786.1 - 0.012 15.5 0.5 0.012 15.5 0.5 2.2 2 0 0 2 2 2 0 AUX/IAA family Plasmodium_Vir PF05795.11 CDI78786.1 - 0.016 14.7 3.8 0.025 14.0 3.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SUIM_assoc PF16619.5 CDI78786.1 - 0.018 15.1 0.9 0.018 15.1 0.9 3.9 2 1 1 3 3 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4834 PF16118.5 CDI78786.1 - 0.032 15.2 0.1 0.032 15.2 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) PA26 PF04636.13 CDI78786.1 - 0.074 12.0 12.4 0.017 14.1 6.2 2.0 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF702 PF05142.12 CDI78786.1 - 0.093 13.2 22.4 0.34 11.4 11.2 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF702) SpoIIIAH PF12685.7 CDI78786.1 - 0.096 12.5 13.9 1.9 8.2 8.0 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein Ctr PF04145.15 CDI78786.1 - 0.13 12.9 7.3 2.3 8.8 1.7 2.8 3 0 0 3 3 3 0 Ctr copper transporter family RNA_pol_Rpc4 PF05132.14 CDI78786.1 - 0.16 12.4 14.5 3.6 8.0 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 TFIIA PF03153.13 CDI78786.1 - 0.26 11.2 42.8 0.15 12.0 24.3 2.5 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit FGF-BP1 PF06473.12 CDI78786.1 - 0.36 10.6 21.8 2.1 8.1 1.0 2.3 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) CCDC53 PF10152.9 CDI78786.1 - 0.5 10.8 24.8 0.19 12.2 12.0 3.1 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex SARAF PF06682.12 CDI78786.1 - 0.63 9.6 19.9 2.3 7.8 11.0 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis YABBY PF04690.13 CDI78786.1 - 0.72 10.4 12.7 5.3 7.6 0.4 2.3 2 0 0 2 2 2 0 YABBY protein Tim54 PF11711.8 CDI78786.1 - 0.78 8.5 13.8 0.83 8.4 6.0 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Dicty_REP PF05086.12 CDI78786.1 - 1.1 7.2 7.2 1.5 6.7 7.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DNApol_Exo PF18136.1 CDI78786.1 - 1.1 8.3 14.3 0.93 8.6 6.9 2.2 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain Nha1_C PF08619.10 CDI78786.1 - 1.6 7.8 25.1 0.56 9.3 12.4 2.1 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus Otopetrin PF03189.13 CDI78786.1 - 2 7.1 5.0 3.3 6.4 5.0 1.3 1 0 0 1 1 1 0 Otopetrin DUF2828 PF11443.8 CDI78786.1 - 2 6.4 21.7 0.12 10.5 13.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF2052 PF09747.9 CDI78786.1 - 3.2 7.8 22.7 9.3 6.3 0.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DAG_kinase_N PF14513.6 CDI78786.1 - 4 7.6 22.0 0.27 11.4 10.5 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Miga PF10265.9 CDI78786.1 - 5.3 5.9 13.0 1.7 7.6 6.5 2.0 2 0 0 2 2 2 0 Mitoguardin V_ATPase_I PF01496.19 CDI78786.1 - 5.6 4.7 20.3 7.9 4.3 15.1 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 CDI78786.1 - 5.7 6.6 12.8 43 3.8 0.0 2.3 2 0 0 2 2 2 0 Connexin PXA PF02194.15 CDI78786.1 - 6.4 6.7 9.2 6.7 6.7 4.0 2.2 2 0 0 2 2 2 0 PXA domain PIP5K PF01504.18 CDI78786.1 - 6.4 5.9 14.1 0.56 9.4 5.3 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF908 PF06012.12 CDI78786.1 - 9.5 5.5 23.5 0.14 11.5 7.1 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) RabGAP-TBC PF00566.18 CDI78787.1 - 9.7e-06 25.4 0.2 0.0049 16.5 0.1 5.3 4 1 1 5 5 5 3 Rab-GTPase-TBC domain Otopetrin PF03189.13 CDI78787.1 - 0.0079 15.1 0.0 0.22 10.3 0.0 2.7 1 1 1 2 2 2 1 Otopetrin DUF3675 PF12428.8 CDI78787.1 - 0.04 14.5 0.1 0.04 14.5 0.1 4.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3675) SUIM_assoc PF16619.5 CDI78787.1 - 0.48 10.5 0.0 0.48 10.5 0.0 8.5 6 2 1 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 MecA PF05389.12 CDI78787.1 - 1.8 8.1 8.7 2.6 7.6 0.9 3.1 3 1 0 3 3 3 0 Negative regulator of genetic competence (MecA) Connexin PF00029.19 CDI78787.1 - 3.7 7.2 9.1 1.1 9.0 0.4 3.2 3 0 0 3 3 3 0 Connexin TGT PF01702.18 CDI78788.1 - 3.1e-32 112.1 4.9 2.3e-11 43.5 0.0 3.4 2 1 1 3 3 3 3 Queuine tRNA-ribosyltransferase zf-C3HC4_2 PF13923.6 CDI78788.1 - 4.7e-10 39.1 13.2 1.4e-09 37.6 13.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI78788.1 - 1.5e-09 37.6 8.3 1.5e-09 37.6 8.3 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI78788.1 - 1e-08 35.3 14.2 1e-08 35.3 14.2 2.7 3 0 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.6 CDI78788.1 - 4.1e-07 29.9 8.0 4.1e-07 29.9 8.0 2.7 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDI78788.1 - 1.5e-06 27.9 10.0 1.5e-06 27.9 10.0 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CDI78788.1 - 5.8e-06 26.1 11.2 5.8e-06 26.1 11.2 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI78788.1 - 3.9e-05 23.5 10.1 3.9e-05 23.5 10.1 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDI78788.1 - 0.00031 20.8 14.0 0.00051 20.2 11.7 2.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Sin_N PF04801.13 CDI78788.1 - 0.0022 17.3 7.8 0.0022 17.3 7.8 3.4 4 0 0 4 4 3 1 Sin-like protein conserved region zf-rbx1 PF12678.7 CDI78788.1 - 0.006 16.8 11.4 0.006 16.8 11.4 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-P11 PF03854.14 CDI78788.1 - 0.032 13.9 8.0 0.076 12.7 8.0 1.6 1 0 0 1 1 1 0 P-11 zinc finger eIF-3_zeta PF05091.12 CDI78788.1 - 0.035 13.1 12.6 0.077 12.0 2.1 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Pet20 PF08692.10 CDI78788.1 - 8.4 7.1 8.7 26 5.5 0.2 3.2 2 0 0 2 2 2 0 Mitochondrial protein Pet20 XRN_M PF17846.1 CDI78788.1 - 8.9 5.1 12.6 1.4 7.8 1.0 3.0 2 0 0 2 2 2 0 Xrn1 helical domain Utp14 PF04615.13 CDI78790.1 - 4.6e-64 217.3 171.9 1.6e-38 132.8 64.4 3.8 2 1 2 4 4 4 2 Utp14 protein RskA PF10099.9 CDI78790.1 - 4.3e-05 23.9 0.2 4.3e-05 23.9 0.2 11.4 1 1 7 9 9 9 3 Anti-sigma-K factor rskA Fip1 PF05182.13 CDI78790.1 - 0.00012 21.5 1.1 0.00033 20.1 1.1 1.8 1 0 0 1 1 1 1 Fip1 motif SUIM_assoc PF16619.5 CDI78790.1 - 0.01 15.9 6.3 0.01 15.9 6.3 16.8 9 5 2 11 11 11 0 Unstructured region C-term to UIM in Ataxin3 Chromo PF00385.24 CDI78791.1 - 5.1e-07 29.5 0.0 1.3e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-RING_7 PF02591.15 CDI78791.1 - 0.037 14.2 0.1 20 5.5 0.0 2.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain SBDS_C PF09377.10 CDI78792.1 - 4.1e-17 62.2 0.0 4.1e-17 62.2 0.0 2.7 3 0 0 3 3 3 1 SBDS protein C-terminal domain SBDS PF01172.18 CDI78792.1 - 0.0018 18.3 0.1 0.0083 16.2 0.0 2.1 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Reprolysin_3 PF13582.6 CDI78792.1 - 0.29 11.7 0.0 0.29 11.7 0.0 4.2 5 0 0 5 5 5 0 Metallo-peptidase family M12B Reprolysin-like GDI PF00996.18 CDI78794.1 - 9.4e-206 683.4 0.0 1.1e-205 683.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.24 CDI78794.1 - 0.027 13.8 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase DAO PF01266.24 CDI78794.1 - 0.054 13.1 0.0 0.097 12.2 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase PPR_2 PF13041.6 CDI78795.1 - 2.1e-35 120.7 0.0 7e-09 35.8 0.1 6.1 3 2 3 7 7 7 5 PPR repeat family PPR_3 PF13812.6 CDI78795.1 - 1.3e-25 89.3 0.0 3.9e-06 26.9 0.0 5.9 3 1 3 6 6 6 6 Pentatricopeptide repeat domain PPR_long PF17177.4 CDI78795.1 - 4.9e-25 88.2 20.6 2.5e-13 49.9 0.7 4.3 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 CDI78795.1 - 2.8e-19 68.0 6.2 0.0035 17.5 0.1 8.3 9 0 0 9 9 9 4 PPR repeat PPR_1 PF12854.7 CDI78795.1 - 8.7e-14 50.9 0.1 0.96 9.2 0.0 7.3 7 0 0 7 7 7 4 PPR repeat DUF572 PF04502.13 CDI78795.1 - 0.48 10.0 39.0 1.9 8.1 4.4 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF572) Glyco_hydro_36C PF16874.5 CDI78795.1 - 2.5 8.6 5.8 1.6 9.3 0.8 3.2 3 0 0 3 3 3 0 Glycosyl hydrolase family 36 C-terminal domain OTU PF02338.19 CDI78796.1 - 1.3e-19 70.9 0.0 3.4e-19 69.6 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease Asn_synthase PF00733.21 CDI78797.1 - 1.4e-63 215.7 0.0 9.6e-37 127.4 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CDI78797.1 - 1.7e-36 124.8 0.0 3e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDI78797.1 - 2.3e-27 95.8 0.0 3.7e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDI78797.1 - 2.9e-08 33.4 0.0 6.6e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein Torus PF16131.5 CDI78799.1 - 3.2e-31 108.2 0.5 3.2e-31 108.2 0.5 2.4 2 1 1 3 3 3 1 Torus domain RRM_1 PF00076.22 CDI78799.1 - 0.0014 18.4 0.0 0.0031 17.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CDI78799.1 - 0.12 12.5 8.7 0.29 11.3 8.7 1.7 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH_3 PF15663.5 CDI78799.1 - 0.21 11.8 2.6 0.23 11.7 0.9 1.9 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_4 PF18044.1 CDI78799.1 - 0.78 9.6 9.2 1.5 8.7 9.2 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger PNK3P PF08645.11 CDI78800.1 - 0.015 15.0 0.1 0.032 13.9 0.1 1.5 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase NIF PF03031.18 CDI78800.1 - 0.025 14.4 0.1 0.04 13.7 0.1 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase DUF2608 PF11019.8 CDI78800.1 - 0.2 11.1 0.7 0.38 10.2 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2608) MOLO1 PF17175.4 CDI78801.1 - 1.4e-26 92.9 0.0 2.3e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 DHHC PF01529.20 CDI78801.1 - 2.6e-16 60.0 3.3 5.1e-16 59.0 3.3 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase TPM_phosphatase PF04536.14 CDI78801.1 - 1.1e-05 25.5 0.0 4.2e-05 23.7 0.0 1.9 1 1 0 1 1 1 1 TPM domain Fcf2 PF08698.11 CDI78804.1 - 2e-10 40.9 0.0 2e-10 40.9 0.0 2.7 2 1 0 2 2 2 1 Fcf2 pre-rRNA processing DUF3169 PF11368.8 CDI78805.1 - 0.098 12.2 0.0 0.88 9.0 0.0 2.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DnaJ PF00226.31 CDI78807.1 - 2e-14 53.5 2.0 2.4e-14 53.2 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain Cyt-b5 PF00173.28 CDI78808.1 - 2.7e-23 81.9 0.1 3.6e-23 81.5 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PspB PF06667.12 CDI78808.1 - 0.071 13.2 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Phage shock protein B Thyroglobulin_1 PF00086.18 CDI78808.1 - 0.1 12.3 1.3 0.2 11.4 1.3 1.4 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat DEAD PF00270.29 CDI78809.1 - 1.2e-41 142.4 0.0 2e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI78809.1 - 4.7e-27 94.5 0.0 1e-26 93.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SecA_DEAD PF07517.14 CDI78809.1 - 0.042 13.1 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 SecA DEAD-like domain mIF3 PF14877.6 CDI78809.1 - 0.058 13.1 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial translation initiation factor cNMP_binding PF00027.29 CDI78810.1 - 7e-19 67.7 0.1 1.8e-18 66.3 0.0 1.7 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Sin_N PF04801.13 CDI78810.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region EF-hand_6 PF13405.6 CDI78811.1 - 4.6e-11 41.7 1.8 1.3e-07 30.9 0.1 4.2 4 1 1 5 5 5 1 EF-hand domain EF-hand_7 PF13499.6 CDI78811.1 - 5e-10 39.7 0.7 1.2e-06 28.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI78811.1 - 2.9e-09 35.8 2.9 2.9e-06 26.4 0.1 4.6 5 0 0 5 5 5 1 EF hand EF-hand_8 PF13833.6 CDI78811.1 - 9.5e-07 28.6 1.9 0.0008 19.2 0.2 3.3 2 2 1 3 3 3 3 EF-hand domain pair DUF3008 PF11450.8 CDI78811.1 - 0.0089 16.2 0.1 0.019 15.1 0.1 1.6 1 0 0 1 1 1 1 Protein of unknwon function (DUF3008) EF-hand_9 PF14658.6 CDI78811.1 - 0.038 14.3 0.0 0.096 13.0 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain EFhand_Ca_insen PF08726.10 CDI78811.1 - 0.061 13.4 0.0 0.24 11.5 0.0 2.1 1 1 1 2 2 2 0 Ca2+ insensitive EF hand LEM PF03020.15 CDI78811.1 - 0.12 12.0 0.2 0.89 9.2 0.2 2.1 2 0 0 2 2 2 0 LEM domain EF-hand_5 PF13202.6 CDI78811.1 - 0.12 11.9 2.9 4.2 7.0 0.1 3.3 3 0 0 3 3 3 0 EF hand EF-hand_14 PF17959.1 CDI78811.1 - 0.13 12.6 0.0 0.26 11.7 0.0 1.6 1 1 1 2 2 2 0 EF-hand domain V-SNARE PF05008.15 CDI78812.1 - 3.3e-07 30.6 0.4 3.3e-07 30.6 0.4 2.0 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Med21 PF11221.8 CDI78812.1 - 0.08 13.2 0.6 0.7 10.1 0.1 2.4 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Mito_carr PF00153.27 CDI78813.1 - 3.6e-10 39.6 2.6 3.1e-05 23.8 0.1 2.7 2 1 0 2 2 2 2 Mitochondrial carrier protein PrcB_C PF14343.6 CDI78813.1 - 0.1 12.7 0.0 2 8.6 0.0 2.3 2 0 0 2 2 2 0 PrcB C-terminal Ribosomal_S8 PF00410.19 CDI78814.1 - 6.6e-21 74.6 0.0 8.1e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 SLBP_RNA_bind PF15247.6 CDI78815.1 - 5.6e-23 80.8 1.6 1.1e-22 79.9 1.6 1.5 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain MIP PF00230.20 CDI78816.1 - 1.9e-19 70.3 14.0 4.8e-19 69.0 14.0 1.6 1 1 0 1 1 1 1 Major intrinsic protein FAM199X PF15814.5 CDI78817.1 - 2.2 7.3 16.3 2.4 7.1 16.3 1.0 1 0 0 1 1 1 0 Protein family FAM199X LMBR1 PF04791.16 CDI78817.1 - 5.6 5.8 6.4 6.8 5.5 6.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Sde2_N_Ubi PF13019.6 CDI78819.1 - 1.7e-12 47.5 0.3 1.7e-12 47.5 0.3 2.4 2 1 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain RAP1 PF07218.11 CDI78819.1 - 0.31 9.3 7.4 0.39 8.9 7.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Rotamase_2 PF13145.6 CDI78819.1 - 6.2 7.7 18.3 0.35 11.7 6.7 3.1 3 0 0 3 3 3 0 PPIC-type PPIASE domain NAM-associated PF14303.6 CDI78819.1 - 7.9 7.2 11.9 21 5.8 11.9 1.7 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain WD40 PF00400.32 CDI78820.1 - 3.9e-09 37.0 0.8 0.00046 20.9 0.4 4.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78820.1 - 0.045 14.1 0.0 2.6 8.4 0.0 3.1 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PTH2 PF01981.16 CDI78821.1 - 1.2e-11 44.9 0.1 2.1e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 MMR_HSR1 PF01926.23 CDI78821.1 - 1.7e-06 28.1 0.4 1.2e-05 25.3 0.2 2.3 2 1 1 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI78821.1 - 0.00046 19.8 0.1 0.0036 16.8 0.1 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDI78821.1 - 0.00096 19.1 0.0 0.44 10.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDI78821.1 - 0.0014 18.7 0.0 0.0025 17.9 0.0 1.4 1 0 0 1 1 1 1 Dynamin family GTP_EFTU PF00009.27 CDI78821.1 - 0.0034 16.9 0.0 11 5.5 0.1 3.2 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain TniB PF05621.11 CDI78821.1 - 0.0045 16.4 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein Roc PF08477.13 CDI78821.1 - 0.0081 16.4 0.0 0.16 12.2 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CDI78821.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CDI78821.1 - 0.09 13.3 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter MOLO1 PF17175.4 CDI78822.1 - 5.2e-25 87.9 0.0 7.4e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 CDI78822.1 - 1.6e-07 31.5 0.0 1.1e-06 28.8 0.0 2.0 1 1 0 1 1 1 1 TPM domain Tweety PF04906.13 CDI78823.1 - 0.17 10.5 12.8 0.16 10.6 10.8 1.8 1 1 1 2 2 2 0 Tweety DUF4400 PF14348.6 CDI78823.1 - 1.3 8.5 4.2 12 5.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4400) Presenilin PF01080.17 CDI78826.1 - 0.29 9.8 2.8 0.49 9.1 2.8 1.4 1 0 0 1 1 1 0 Presenilin UTP15_C PF09384.10 CDI78828.1 - 4.4e-13 49.2 0.1 4.4e-13 49.2 0.1 1.7 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.32 CDI78828.1 - 2.4e-07 31.3 6.9 0.0013 19.6 0.0 6.3 6 1 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI78828.1 - 1.4e-05 25.3 0.0 0.49 10.7 0.0 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SUIM_assoc PF16619.5 CDI78828.1 - 0.0087 16.1 18.4 0.059 13.5 2.5 2.7 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 AAA_23 PF13476.6 CDI78828.1 - 0.046 14.2 5.4 1.1 9.7 2.5 2.3 2 0 0 2 2 2 0 AAA domain TFIIA PF03153.13 CDI78828.1 - 0.17 11.8 15.0 1.6 8.7 7.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MFAP1 PF06991.11 CDI78828.1 - 1.3 8.8 7.3 0.13 12.1 2.3 1.7 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing PA26 PF04636.13 CDI78828.1 - 1.3 7.8 4.0 2.7 6.8 2.3 1.9 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Activator_LAG-3 PF11498.8 CDI78828.1 - 1.9 7.4 16.7 1.3 7.9 3.0 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI78828.1 - 7 6.2 19.4 3.5 7.2 1.3 2.3 2 0 0 2 2 2 0 Spt20 family Rotamase_2 PF13145.6 CDI78828.1 - 9.5 7.1 9.5 2 9.3 1.3 2.6 2 0 0 2 2 2 0 PPIC-type PPIASE domain Spt20 PF12090.8 CDI78829.1 - 0.0049 16.5 4.0 0.0049 16.5 4.0 3.2 3 0 0 3 3 3 2 Spt20 family SUIM_assoc PF16619.5 CDI78829.1 - 0.0059 16.7 40.7 0.048 13.7 0.7 3.6 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 DUF4131 PF13567.6 CDI78829.1 - 0.086 12.5 3.8 4 7.1 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Syntaxin-18_N PF10496.9 CDI78829.1 - 0.53 10.6 4.3 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus DUF4834 PF16118.5 CDI78829.1 - 1.1 10.2 17.2 1.7 9.7 0.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI78829.1 - 1.3 7.9 32.6 0.022 13.7 2.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Dpy-30 PF05186.13 CDI78830.1 - 5.9e-14 51.5 0.9 8.9e-14 50.9 0.9 1.3 1 0 0 1 1 1 1 Dpy-30 motif DNA_pol_A PF00476.20 CDI78831.1 - 8.4e-52 176.5 0.1 7.7e-32 110.8 0.0 3.7 2 1 1 3 3 3 2 DNA polymerase family A SUIM_assoc PF16619.5 CDI78831.1 - 0.27 11.3 0.0 0.27 11.3 0.0 6.2 2 2 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 EOS1 PF12326.8 CDI78831.1 - 0.41 10.5 1.6 39 4.1 5.5 2.2 2 0 0 2 2 2 0 N-glycosylation protein Exonuc_VII_L PF02601.15 CDI78831.1 - 0.45 10.0 14.3 0.9 9.0 14.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Neur_chan_memb PF02932.16 CDI78831.1 - 1.6 8.7 13.6 4.9 7.1 13.6 1.9 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2464 PF10240.9 CDI78831.1 - 4.2 6.9 11.8 10 5.6 11.8 1.5 1 0 0 1 1 1 0 Multivesicular body subunit 12 Lin-8 PF03353.15 CDI78831.1 - 6.4 6.2 22.3 14 5.1 22.3 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI78831.1 - 8.4 3.4 15.4 13 2.7 15.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Zip PF02535.22 CDI78831.1 - 9 5.4 9.4 19 4.3 9.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 CDI78831.1 - 9.2 5.1 9.9 20 4.0 9.9 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) tRNA-synt_1c_C PF03950.18 CDI78832.1 - 0.0025 17.7 1.0 0.014 15.2 1.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain RskA PF10099.9 CDI78833.1 - 0.00044 20.6 1.4 0.0006 20.2 1.4 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA FHIPEP PF00771.20 CDI78833.1 - 0.0013 17.3 0.9 0.0017 17.0 0.9 1.1 1 0 0 1 1 1 1 FHIPEP family V_ATPase_I PF01496.19 CDI78833.1 - 0.0023 15.9 0.4 0.0024 15.9 0.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CPSF100_C PF13299.6 CDI78833.1 - 0.0029 17.8 2.0 0.0047 17.1 2.0 1.4 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Ureide_permease PF07168.11 CDI78833.1 - 0.0031 16.3 1.7 0.0042 15.9 1.7 1.1 1 0 0 1 1 1 1 Ureide permease FAM176 PF14851.6 CDI78833.1 - 0.014 15.1 0.9 0.024 14.3 0.9 1.5 1 0 0 1 1 1 0 FAM176 family PA26 PF04636.13 CDI78833.1 - 0.022 13.7 1.2 0.027 13.4 1.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Connexin PF00029.19 CDI78833.1 - 0.023 14.5 0.4 0.032 14.0 0.4 1.2 1 0 0 1 1 1 0 Connexin TRAP_alpha PF03896.16 CDI78833.1 - 0.024 13.9 2.0 0.032 13.4 2.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit O-antigen_lig PF13425.6 CDI78833.1 - 0.029 13.1 0.0 0.039 12.8 0.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3742 PF12553.8 CDI78833.1 - 0.03 14.4 1.5 0.07 13.2 1.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3742) DDHD PF02862.17 CDI78833.1 - 0.033 14.3 0.8 0.039 14.1 0.8 1.2 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 CDI78833.1 - 0.04 13.0 0.2 0.048 12.7 0.2 1.1 1 0 0 1 1 1 0 CLN3 protein DUF1180 PF06679.12 CDI78833.1 - 0.048 14.1 0.6 0.048 14.1 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Serinc PF03348.15 CDI78833.1 - 0.068 12.1 0.2 0.084 11.8 0.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4820 PF16091.5 CDI78833.1 - 0.075 12.4 3.9 0.11 11.9 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Mem_trans PF03547.18 CDI78833.1 - 0.1 10.9 0.2 0.12 10.7 0.2 1.1 1 0 0 1 1 1 0 Membrane transport protein Neur_chan_memb PF02932.16 CDI78833.1 - 0.13 12.3 0.2 0.13 12.3 0.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spec3 PF15795.5 CDI78833.1 - 0.14 12.7 11.3 1.2e+02 3.3 11.3 2.3 1 1 0 1 1 1 0 Ectodermal ciliogenesis protein Git3 PF11710.8 CDI78833.1 - 0.14 11.9 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 SID-1_RNA_chan PF13965.6 CDI78833.1 - 0.16 10.4 0.2 0.18 10.1 0.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 CDI78833.1 - 0.2 12.6 6.9 0.44 11.5 6.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DREPP PF05558.12 CDI78833.1 - 0.21 11.4 4.2 0.32 10.8 4.2 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide DUF4770 PF15994.5 CDI78833.1 - 0.35 11.1 5.3 0.49 10.6 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RasGAP PF00616.19 CDI78833.1 - 0.79 9.4 8.7 1.1 9.0 8.7 1.2 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase SLC12 PF03522.15 CDI78833.1 - 0.85 8.6 6.3 1.1 8.2 6.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TFIIA PF03153.13 CDI78833.1 - 2.1 8.3 21.5 3.2 7.7 21.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.8 CDI78833.1 - 2.4 7.2 21.8 3.3 6.8 21.8 1.1 1 0 0 1 1 1 0 SprA-related family DUF2722 PF10846.8 CDI78833.1 - 3 6.7 19.8 4.3 6.2 19.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CobT PF06213.12 CDI78833.1 - 4.8 6.5 22.0 7.7 5.8 22.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 CDI78833.1 - 7.3 4.7 11.4 10 4.3 11.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 CDI78834.1 - 1.1 8.4 20.9 0.033 13.4 5.1 3.3 3 0 0 3 3 3 0 ZIP Zinc transporter SelP_N PF04592.14 CDI78834.1 - 2 7.8 33.5 0.26 10.7 28.7 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region RskA PF10099.9 CDI78836.1 - 6.8e-05 23.2 0.5 6.8e-05 23.2 0.5 4.5 2 2 1 3 3 3 2 Anti-sigma-K factor rskA Cellulose_synt PF03552.14 CDI78836.1 - 2.1 6.7 3.9 3.4 6.0 3.9 1.2 1 0 0 1 1 1 0 Cellulose synthase V_ATPase_I PF01496.19 CDI78836.1 - 4.5 5.1 8.1 7 4.4 8.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RHD3 PF05879.12 CDI78838.1 - 1.6e-102 344.0 4.8 2.5e-88 297.1 0.0 2.9 3 0 0 3 3 2 2 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 CDI78838.1 - 0.00032 20.8 8.3 0.00084 19.4 0.1 3.3 2 1 1 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 CDI78838.1 - 0.00053 20.0 0.1 0.0017 18.4 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase SPX PF03105.19 CDI78838.1 - 0.0014 18.6 18.0 0.11 12.3 2.2 2.2 2 0 0 2 2 2 2 SPX domain DUF4717 PF15838.5 CDI78838.1 - 0.0043 17.0 2.8 0.16 12.0 3.9 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4717) AAA_23 PF13476.6 CDI78838.1 - 0.0079 16.7 0.0 0.0079 16.7 0.0 3.5 4 0 0 4 4 3 1 AAA domain DDHD PF02862.17 CDI78838.1 - 0.0096 16.1 13.6 0.66 10.1 7.4 2.5 2 0 0 2 2 2 2 DDHD domain AAA_29 PF13555.6 CDI78838.1 - 0.089 12.5 0.1 0.22 11.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 CDI78838.1 - 0.094 12.9 0.0 0.094 12.9 0.0 3.1 3 0 0 3 3 2 0 AAA domain Cyt_c_ox_IV PF12270.8 CDI78838.1 - 0.2 11.8 0.0 0.2 11.8 0.0 2.5 2 0 0 2 2 1 0 Cytochrome c oxidase subunit IV Zip PF02535.22 CDI78838.1 - 0.59 9.3 11.3 2.6 7.2 0.5 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter Pkinase_fungal PF17667.1 CDI78838.1 - 0.81 8.4 10.2 3.8 6.2 0.3 2.2 2 0 0 2 2 2 0 Fungal protein kinase Presenilin PF01080.17 CDI78838.1 - 1.2 7.8 23.5 0.18 10.5 12.7 2.2 2 0 0 2 2 2 0 Presenilin Sec16 PF12932.7 CDI78838.1 - 1.7 9.3 6.6 7.7 7.1 6.6 2.2 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region DUF572 PF04502.13 CDI78838.1 - 2.8 7.5 24.3 4.5 6.8 12.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI78838.1 - 3.4 7.6 51.8 0.025 14.6 35.5 2.6 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI78838.1 - 3.8 7.5 17.1 11 5.9 0.2 2.4 2 0 0 2 2 2 0 Protein Family FAM60A Septin PF00735.18 CDI78838.1 - 4.2 6.6 6.7 0.48 9.6 0.2 2.4 2 0 0 2 2 2 0 Septin Plasmodium_Vir PF05795.11 CDI78838.1 - 5.7 6.2 9.9 5.6 6.3 0.3 2.3 2 0 0 2 2 2 0 Plasmodium vivax Vir protein MMR1 PF08505.10 CDI78838.1 - 6.3 7.0 26.3 3.2 8.0 14.6 3.1 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein Exonuc_VII_L PF02601.15 CDI78838.1 - 8.2 5.9 23.9 0.45 10.0 14.4 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit tRNA-synt_1 PF00133.22 CDI78840.1 - 5.6e-26 91.0 0.6 3.6e-10 38.7 0.0 5.4 4 1 1 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDI78840.1 - 1.3e-14 53.8 0.1 4.1e-05 22.5 0.0 4.0 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CDI78840.1 - 2e-11 44.1 0.2 6.8e-11 42.4 0.2 1.9 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA SR-25 PF10500.9 CDI78840.1 - 1e-05 25.3 14.4 1e-05 25.3 14.4 7.5 5 3 2 7 7 7 1 Nuclear RNA-splicing-associated protein Pex14_N PF04695.13 CDI78840.1 - 0.00061 20.5 8.9 0.00061 20.5 8.9 8.9 7 3 2 10 10 10 1 Peroxisomal membrane anchor protein (Pex14p) conserved region tRNA-synt_1_2 PF13603.6 CDI78840.1 - 0.0013 18.3 0.0 0.0045 16.5 0.0 1.9 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Zip PF02535.22 CDI78840.1 - 0.0061 15.8 0.1 0.0061 15.8 0.1 4.9 4 1 0 4 4 4 1 ZIP Zinc transporter DUF155 PF02582.14 CDI78842.1 - 1.7e-21 77.1 0.1 3e-21 76.3 0.0 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 WD40 PF00400.32 CDI78845.1 - 0.00071 20.3 2.8 18 6.4 0.2 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat GAS PF13851.6 CDI78846.1 - 9.3e-39 132.8 16.9 9.3e-39 132.8 16.9 3.3 2 1 0 3 3 3 1 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 CDI78846.1 - 5e-06 26.5 17.1 5e-06 26.5 17.1 3.4 3 1 1 4 4 4 1 Coiled-coil region of CCDC155 or KASH GCP_C_terminal PF04130.13 CDI78847.1 - 8.6e-11 41.9 5.9 6.5e-09 35.7 0.1 3.3 3 1 1 4 4 4 2 Gamma tubulin complex component C-terminal Isy1 PF06246.12 CDI78847.1 - 0.41 10.2 8.8 0.46 10.0 0.2 3.6 3 0 0 3 3 3 0 Isy1-like splicing family DUF2126 PF09899.9 CDI78848.1 - 0.6 8.1 10.8 0.5 8.4 10.8 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF1682 PF07946.14 CDI78848.1 - 0.68 9.1 12.2 0.72 9.0 12.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Serinc PF03348.15 CDI78848.1 - 0.92 8.4 12.1 1.2 7.9 12.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) FHIPEP PF00771.20 CDI78848.1 - 1.2 7.5 7.5 1.3 7.4 7.5 1.3 1 0 0 1 1 1 0 FHIPEP family CobT PF06213.12 CDI78848.1 - 2.8 7.3 31.5 0.63 9.4 25.9 1.9 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 CDI78848.1 - 3.7 7.4 56.4 4.6 7.1 56.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cellulose_synt PF03552.14 CDI78848.1 - 9.2 4.6 7.1 11 4.4 7.1 1.1 1 0 0 1 1 1 0 Cellulose synthase TPR_16 PF13432.6 CDI78849.1 - 1.6e-07 31.9 21.3 2.9e-05 24.6 7.1 16.6 16 4 3 19 19 19 6 Tetratricopeptide repeat TPR_2 PF07719.17 CDI78849.1 - 5.5e-07 29.2 33.8 0.00011 22.0 1.1 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDI78849.1 - 0.0068 16.2 0.3 0.0068 16.2 0.3 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI78849.1 - 0.27 12.2 0.0 0.27 12.2 0.0 15.0 15 2 2 17 17 17 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI78849.1 - 0.39 11.1 6.6 1.3 9.4 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TAXi_N PF14543.6 CDI78851.1 - 1.6e-09 38.2 1.5 1.6e-09 38.2 1.5 1.8 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TFIIA PF03153.13 CDI78851.1 - 0.0041 17.2 3.1 0.0053 16.8 3.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Asp PF00026.23 CDI78851.1 - 0.0062 16.0 0.1 0.0092 15.4 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease DUF755 PF05501.11 CDI78851.1 - 0.023 14.9 3.2 0.023 14.9 3.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) SIT PF15330.6 CDI78851.1 - 0.077 13.5 0.5 0.15 12.5 0.5 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF5470 PF17564.2 CDI78851.1 - 3.1 8.1 7.6 9.1 6.6 7.6 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5470) Ndc1_Nup PF09531.10 CDI78851.1 - 3.6 6.2 6.8 4.5 5.8 6.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RCC1_2 PF13540.6 CDI78852.1 - 9.1e-14 50.8 23.8 6.4e-06 25.8 0.0 7.0 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CDI78852.1 - 3.7e-13 49.9 18.9 6e-08 33.2 0.3 7.7 8 2 0 8 8 8 3 Regulator of chromosome condensation (RCC1) repeat Kelch_2 PF07646.15 CDI78852.1 - 0.35 10.9 3.2 12 6.0 0.0 3.7 3 0 0 3 3 3 0 Kelch motif Terminase_GpA PF05876.12 CDI78853.1 - 0.07 11.7 0.0 0.076 11.6 0.0 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) EamA PF00892.20 CDI78854.1 - 4.1e-06 27.0 4.7 4.1e-06 27.0 4.7 2.8 2 1 1 3 3 3 1 EamA-like transporter family Nuc_sug_transp PF04142.15 CDI78854.1 - 0.0066 15.7 0.4 0.017 14.3 0.4 1.6 1 1 0 1 1 1 1 Nucleotide-sugar transporter CRT-like PF08627.10 CDI78854.1 - 0.026 13.5 0.0 0.043 12.8 0.0 1.4 1 0 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 CDI78854.1 - 0.069 12.5 0.6 0.67 9.3 0.1 2.3 2 1 0 2 2 2 0 Triose-phosphate Transporter family MMPL PF03176.15 CDI78854.1 - 1.9 7.4 8.5 0.26 10.2 3.5 2.2 3 0 0 3 3 3 0 MMPL family Hexapep PF00132.24 CDI78856.1 - 0.00067 19.3 14.9 0.17 11.6 6.8 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 CDI78856.1 - 0.0059 14.8 2.4 0.0088 14.2 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) SPX PF03105.19 CDI78856.1 - 0.35 10.7 19.7 0.076 12.9 6.8 3.3 3 0 0 3 3 3 0 SPX domain Spt20 PF12090.8 CDI78856.1 - 3.9 7.0 23.6 1.4 8.5 5.1 3.4 3 0 0 3 3 3 0 Spt20 family Mito_carr PF00153.27 CDI78857.1 - 8.5e-09 35.2 2.1 4.6e-07 29.7 0.0 2.6 2 1 1 3 3 3 1 Mitochondrial carrier protein DUF2722 PF10846.8 CDI78857.1 - 0.025 13.5 13.7 0.027 13.4 13.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI78857.1 - 0.17 11.5 17.8 0.2 11.2 17.8 1.1 1 0 0 1 1 1 0 Spt20 family BCS1_N PF08740.11 CDI78857.1 - 0.21 11.5 3.7 0.27 11.2 3.7 1.1 1 0 0 1 1 1 0 BCS1 N terminal TFIIA PF03153.13 CDI78857.1 - 0.33 10.9 15.6 0.39 10.7 15.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3573 PF12097.8 CDI78857.1 - 0.58 8.9 3.1 0.64 8.8 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) 60KD_IMP PF02096.20 CDI78857.1 - 1 9.3 7.1 1.7 8.5 7.1 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein CHD5 PF04420.14 CDI78857.1 - 2.7 7.8 10.0 2.1 8.2 8.4 1.6 2 0 0 2 2 2 0 CHD5-like protein QueH PF02677.14 CDI78858.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH Peptidase_S8 PF00082.22 CDI78859.1 - 8.5e-18 64.6 0.1 8.5e-18 64.6 0.1 2.2 2 0 0 2 2 1 1 Subtilase family SUIM_assoc PF16619.5 CDI78859.1 - 0.0087 16.1 1.1 0.0087 16.1 1.1 7.7 4 2 3 7 7 3 3 Unstructured region C-term to UIM in Ataxin3 Velvet PF11754.8 CDI78859.1 - 0.036 14.0 25.9 0.63 9.9 9.3 2.4 2 0 0 2 2 2 0 Velvet factor SID-1_RNA_chan PF13965.6 CDI78859.1 - 0.18 10.2 11.8 0.28 9.5 1.4 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI78859.1 - 0.56 9.8 28.1 0.28 10.8 6.7 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF572) SAGA-Tad1 PF12767.7 CDI78859.1 - 1 9.1 26.5 2.1 8.0 10.9 2.6 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit AAA_11 PF13086.6 CDI78859.1 - 1.2 8.8 28.7 2.4 7.9 13.3 2.6 2 0 0 2 2 2 0 AAA domain Presenilin PF01080.17 CDI78859.1 - 1.3 7.7 44.9 2 7.1 15.0 2.4 2 0 0 2 2 2 0 Presenilin Serinc PF03348.15 CDI78859.1 - 1.4 7.8 16.0 1.3 7.9 3.1 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) POP1 PF06978.11 CDI78859.1 - 3.3 7.6 29.0 0.24 11.4 13.3 2.5 2 0 0 2 2 2 0 Ribonucleases P/MRP protein subunit POP1 DUF4045 PF13254.6 CDI78859.1 - 4.4 6.8 31.9 2.1 7.9 13.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) Na_trans_assoc PF06512.13 CDI78859.1 - 5.4 7.2 21.8 3.6 7.8 6.8 2.6 2 0 0 2 2 2 0 Sodium ion transport-associated Endostatin PF06482.11 CDI78859.1 - 9.2 5.6 29.9 9.8 5.5 13.4 2.5 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Rad54_N PF08658.10 CDI78860.1 - 0.024 14.8 1.9 0.024 14.8 1.9 3.4 3 0 0 3 3 3 0 Rad54 N terminal RskA PF10099.9 CDI78860.1 - 0.05 13.9 0.7 0.05 13.9 0.7 5.2 3 1 0 3 3 3 0 Anti-sigma-K factor rskA RPN2_C PF18004.1 CDI78860.1 - 5.1 7.0 21.8 5.5 6.9 8.1 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2681 PF10883.8 CDI78860.1 - 8.8 6.8 32.5 4.3 7.8 14.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) HemX PF04375.14 CDI78860.1 - 9.3 5.4 44.6 0.86 8.8 18.0 2.3 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase GILT PF03227.16 CDI78862.1 - 2.5e-20 72.7 0.1 8.7e-20 71.0 0.1 1.9 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) HECT PF00632.25 CDI78863.1 - 4.4e-52 177.5 0.0 7.8e-52 176.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4605 PF15378.6 CDI78864.1 - 0.035 14.0 0.5 0.081 12.8 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) Glycophorin_A PF01102.18 CDI78864.1 - 0.11 12.7 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A Nkap_C PF06047.11 CDI78866.1 - 1.9e-47 159.5 2.6 1.9e-47 159.5 2.6 2.5 3 0 0 3 3 3 1 NF-kappa-B-activating protein C-terminal domain IMUP PF15761.5 CDI78866.1 - 0.014 16.1 18.4 0.014 16.1 18.4 3.2 2 1 1 3 3 3 0 Immortalisation up-regulated protein RskA PF10099.9 CDI78866.1 - 0.023 15.0 22.8 0.2 11.9 1.5 2.5 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Collar PF07484.12 CDI78866.1 - 0.057 13.4 0.3 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 Phage Tail Collar Domain DUF3006 PF11213.8 CDI78866.1 - 0.079 13.2 4.1 0.16 12.2 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) DUF4887 PF16228.5 CDI78866.1 - 0.24 11.5 30.0 0.048 13.9 9.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4887) Utp14 PF04615.13 CDI78866.1 - 0.44 9.1 46.1 0.0025 16.5 37.8 1.3 2 0 0 2 2 2 0 Utp14 protein SBE2 PF17076.5 CDI78866.1 - 0.98 7.6 13.5 1.5 7.0 13.5 1.3 1 0 0 1 1 1 0 SBE2, cell-wall formation Orthopox_A36R PF05950.11 CDI78866.1 - 1.4 9.1 7.5 4.8 7.3 1.8 2.2 2 0 0 2 2 2 0 Orthopoxvirus A36R protein UPF0688 PF15772.5 CDI78866.1 - 5.3 7.2 32.7 1.6 9.0 14.5 2.5 2 0 0 2 2 2 0 UPF0688 family tRNA-synt_1b PF00579.25 CDI78867.1 - 1.5e-07 31.1 0.0 3.7e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_60s PF00428.19 CDI78867.1 - 0.0017 18.9 9.4 0.034 14.7 2.2 2.9 2 0 0 2 2 2 2 60s Acidic ribosomal protein Androgen_recep PF02166.16 CDI78867.1 - 0.0052 15.7 0.8 0.0052 15.7 0.8 2.4 3 0 0 3 3 3 1 Androgen receptor RskA PF10099.9 CDI78867.1 - 0.026 14.8 9.0 0.067 13.5 3.2 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF1180 PF06679.12 CDI78867.1 - 0.88 10.0 7.9 0.075 13.4 1.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) DUF2057 PF09829.9 CDI78867.1 - 1.6 8.8 6.8 4.5 7.4 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2057) HSP70 PF00012.20 CDI78868.1 - 7.8e-19 67.3 8.1 2.6e-06 25.9 0.0 4.7 2 1 2 4 4 4 3 Hsp70 protein Fis1_TPR_C PF14853.6 CDI78868.1 - 8.9e-05 22.5 3.0 0.00014 21.9 0.5 2.7 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 CDI78868.1 - 0.00022 21.3 3.8 0.0014 18.7 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI78868.1 - 0.0035 17.1 8.3 0.0088 15.8 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat ATG2_CAD PF13329.6 CDI78868.1 - 0.0078 16.0 0.6 0.19 11.4 0.0 2.5 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif PIP5K PF01504.18 CDI78868.1 - 0.015 14.5 0.3 0.046 12.9 0.0 1.9 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase RskA PF10099.9 CDI78868.1 - 0.016 15.5 28.3 4.5 7.5 1.9 4.9 1 1 3 4 4 4 0 Anti-sigma-K factor rskA PAXNEB PF05625.11 CDI78868.1 - 0.025 13.7 2.2 1.3 8.1 0.2 2.6 2 0 0 2 2 2 0 PAXNEB protein TPR_2 PF07719.17 CDI78868.1 - 0.03 14.4 0.2 0.03 14.4 0.2 5.5 5 1 0 6 6 6 0 Tetratricopeptide repeat DUF4834 PF16118.5 CDI78868.1 - 0.038 14.9 6.7 3.9 8.5 0.5 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) CitMHS_2 PF16980.5 CDI78868.1 - 0.26 9.9 0.0 0.46 9.1 0.0 1.3 1 0 0 1 1 1 0 Putative citrate transport TPR_11 PF13414.6 CDI78868.1 - 0.52 10.0 5.4 9.3 6.0 0.2 3.6 2 1 1 3 3 3 0 TPR repeat DUF979 PF06166.12 CDI78868.1 - 0.8 8.8 2.9 0.69 9.0 0.3 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF979) RAB3GAP2_N PF14655.6 CDI78868.1 - 0.82 8.9 8.0 0.57 9.4 0.1 2.8 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Rpp20 PF12328.8 CDI78868.1 - 3.3 7.7 9.3 18 5.3 0.1 4.2 4 0 0 4 4 4 0 Rpp20 subunit of nuclear RNase MRP and P NYAP_N PF15439.6 CDI78868.1 - 3.8 6.6 10.2 0.32 10.2 1.2 2.7 3 0 0 3 3 3 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter SARAF PF06682.12 CDI78868.1 - 5.4 6.6 9.0 2.7 7.6 0.1 2.6 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis RNA_pol_Rpc4 PF05132.14 CDI78869.1 - 0.087 13.2 0.0 0.087 13.2 0.0 3.9 2 1 1 3 3 3 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 CDI78869.1 - 2.5 8.2 6.8 0.35 11.1 0.5 2.5 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DEC-1_N PF04625.13 CDI78871.1 - 0.013 14.5 13.3 0.017 14.2 13.3 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF3292 PF11696.8 CDI78871.1 - 0.033 12.6 6.2 0.034 12.5 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) TMEM171 PF15471.6 CDI78871.1 - 0.32 9.9 5.8 0.48 9.4 5.8 1.4 1 1 0 1 1 1 0 Transmembrane protein family 171 Spt20 PF12090.8 CDI78871.1 - 0.88 9.1 12.1 1.2 8.7 12.1 1.3 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI78871.1 - 1.1 8.3 8.3 1.4 7.9 8.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein RskA PF10099.9 CDI78872.1 - 4.1e-05 24.0 1.0 4.1e-05 24.0 1.0 17.3 6 6 6 12 12 12 2 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI78875.1 - 0.54 10.8 5.2 1.3 9.5 5.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) Ribosomal_60s PF00428.19 CDI78875.1 - 1.5 9.5 10.8 2.4 8.8 10.8 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3446 PF11928.8 CDI78875.1 - 1.6 9.1 13.0 2.2 8.6 1.6 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Activator_LAG-3 PF11498.8 CDI78875.1 - 1.8 7.5 35.1 2.2 7.2 35.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Utp14 PF04615.13 CDI78876.1 - 3.9 5.9 29.0 5.8 5.4 29.0 1.2 1 0 0 1 1 1 0 Utp14 protein AAA_assoc PF14363.6 CDI78879.1 - 0.015 15.6 0.1 0.032 14.6 0.1 1.5 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA Radical_SAM_N PF08497.10 CDI78879.1 - 0.17 11.1 3.0 0.2 10.9 3.0 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal Perilipin PF03036.16 CDI78879.1 - 0.19 10.7 11.1 0.21 10.6 11.1 1.1 1 0 0 1 1 1 0 Perilipin family RNA_pol_3_Rpc31 PF11705.8 CDI78879.1 - 0.43 10.8 9.0 0.53 10.5 9.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Exonuc_VII_L PF02601.15 CDI78879.1 - 1 8.8 12.5 1.2 8.7 12.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 CDI78879.1 - 1.4 7.8 9.0 1.5 7.6 9.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 CDI78879.1 - 1.8 7.8 7.2 1.9 7.7 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 CDI78879.1 - 2.6 8.1 20.9 3.9 7.5 20.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HemX PF04375.14 CDI78879.1 - 3.3 6.9 21.0 4.2 6.5 21.0 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CSRNP_N PF16019.5 CDI78879.1 - 3.7 7.4 12.4 5.3 6.9 12.4 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF745 PF05335.13 CDI78879.1 - 4.1 7.1 15.0 4 7.1 13.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) V_ATPase_I PF01496.19 CDI78879.1 - 6.1 4.6 9.5 6.5 4.5 9.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Baculo_PP31 PF05311.11 CDI78881.1 - 2 7.9 7.1 3.2 7.2 7.1 1.5 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Plasmodium_Vir PF05795.11 CDI78881.1 - 2.4 7.5 4.9 4.7 6.5 4.9 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF1764 PF08576.10 CDI78881.1 - 7.5 7.5 9.6 19 6.2 9.6 1.7 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) GAGA_bind PF06217.12 CDI78882.1 - 0.16 12.2 20.3 0.25 11.6 20.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Kelch_5 PF13854.6 CDI78884.1 - 3.8e-10 39.5 0.0 3.1e-07 30.2 0.0 3.8 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 CDI78884.1 - 6.2e-08 32.5 0.9 0.0043 17.0 0.0 4.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI78884.1 - 5.9e-06 26.4 9.1 0.26 11.6 0.0 5.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI78884.1 - 3e-05 24.1 1.0 0.023 15.0 0.0 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 CDI78884.1 - 0.0026 17.3 0.3 0.24 11.0 0.0 3.6 3 0 0 3 3 3 1 Kelch motif UPF0203 PF05254.12 CDI78885.1 - 1.2e-16 60.7 1.3 1.8e-16 60.1 1.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Tmemb_cc2 PF10267.9 CDI78885.1 - 0.014 14.5 7.9 0.018 14.2 7.9 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Raftlin PF15250.6 CDI78885.1 - 0.38 9.4 4.9 0.45 9.2 4.9 1.0 1 0 0 1 1 1 0 Raftlin Ashwin PF15323.6 CDI78885.1 - 1.2 9.2 11.4 1.6 8.7 11.4 1.2 1 0 0 1 1 1 0 Developmental protein Menin PF05053.13 CDI78885.1 - 2.9 6.2 8.6 3.3 5.9 8.6 1.1 1 0 0 1 1 1 0 Menin SPX PF03105.19 CDI78885.1 - 2.9 7.7 12.9 3.2 7.6 12.9 1.1 1 0 0 1 1 1 0 SPX domain RAP1 PF07218.11 CDI78885.1 - 4.6 5.4 11.3 5.9 5.0 11.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Zip PF02535.22 CDI78885.1 - 5.1 6.2 4.3 5.5 6.1 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI78885.1 - 5.5 5.6 7.3 6.2 5.5 7.3 1.0 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CDI78885.1 - 7.6 4.5 7.8 8.7 4.3 7.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Apt1 PF10351.9 CDI78885.1 - 9.5 4.9 12.7 10 4.8 12.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-RING_2 PF13639.6 CDI78887.1 - 1.6e-11 44.4 8.9 1.6e-11 44.4 8.9 2.3 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDI78887.1 - 2.2e-08 33.8 8.2 6.2e-08 32.4 8.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDI78887.1 - 2.1e-06 27.4 8.5 5.9e-06 25.9 8.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 CDI78887.1 - 3.2e-06 27.0 6.6 8.2e-06 25.7 6.6 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CDI78887.1 - 6.4e-06 26.4 11.5 6.2e-05 23.2 11.5 2.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDI78887.1 - 0.00023 21.0 7.1 0.00023 21.0 7.1 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI78887.1 - 0.00026 20.8 7.4 0.00026 20.8 7.4 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDI78887.1 - 0.028 14.0 7.8 0.07 12.8 7.8 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDI78887.1 - 0.14 12.2 4.7 0.45 10.6 4.7 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CDI78887.1 - 0.6 10.2 11.4 0.24 11.4 7.8 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-P11 PF03854.14 CDI78887.1 - 4.3 7.1 8.6 1.3 8.7 5.0 2.1 2 1 0 2 2 2 0 P-11 zinc finger Prok-RING_4 PF14447.6 CDI78887.1 - 7 6.6 18.4 0.36 10.7 10.1 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 MOZ_SAS PF01853.18 CDI78888.1 - 3.6e-50 170.1 0.4 3e-48 163.8 0.1 2.8 2 1 0 2 2 2 1 MOZ/SAS family Tudor-knot PF11717.8 CDI78888.1 - 2.2e-10 40.2 0.0 1.3e-09 37.8 0.0 2.1 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CDI78888.1 - 0.0081 16.6 0.0 0.017 15.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PP2C PF00481.21 CDI78890.1 - 6.6e-35 121.0 0.0 4e-34 118.4 0.0 2.0 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI78890.1 - 0.0067 16.4 0.0 0.18 11.7 0.0 2.5 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) eIF-3_zeta PF05091.12 CDI78890.1 - 0.25 10.2 4.9 0.36 9.8 4.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) E1-E2_ATPase PF00122.20 CDI78892.1 - 1.7e-40 138.5 0.2 1.7e-40 138.5 0.2 2.4 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 CDI78892.1 - 1.1e-19 69.8 0.0 2.7e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 CDI78892.1 - 2e-16 60.9 4.8 1e-14 55.4 4.8 3.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI78892.1 - 4.1e-15 55.6 0.0 2.2e-14 53.3 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 CDI78892.1 - 4.6e-11 42.8 2.1 1.8e-10 40.8 0.0 2.5 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase_3 PF08282.12 CDI78892.1 - 0.0039 17.0 1.2 0.0065 16.2 0.6 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDI78892.1 - 0.014 15.8 0.0 0.037 14.4 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MAD PF05557.13 CDI78892.1 - 0.28 9.5 18.3 0.44 8.9 18.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein GAS PF13851.6 CDI78892.1 - 1.2 8.4 22.8 0.19 11.1 12.2 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Helo_like_N PF17111.5 CDI78892.1 - 1.7 8.0 7.9 2.6 7.3 7.0 1.8 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins FlxA PF14282.6 CDI78892.1 - 3.3 7.7 16.2 0.15 12.0 9.6 2.2 2 0 0 2 2 2 0 FlxA-like protein SpoIIM PF01944.17 CDI78892.1 - 6.4 6.8 12.4 1.5 8.8 0.0 3.6 4 0 0 4 4 4 0 Stage II sporulation protein M ATPase_gene1 PF09527.10 CDI78892.1 - 7.8 6.7 6.3 1.9 8.7 0.8 2.6 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter SR-25 PF10500.9 CDI78896.1 - 4.1e-06 26.6 16.1 4.1e-06 26.6 16.1 4.2 3 1 1 4 4 2 1 Nuclear RNA-splicing-associated protein WD40 PF00400.32 CDI78896.1 - 1.7e-05 25.4 0.3 0.027 15.3 0.1 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Apt1 PF10351.9 CDI78896.1 - 2.5e-05 23.4 27.9 0.0013 17.7 9.0 2.1 2 0 0 2 2 2 2 Golgi-body localisation protein domain SARAF PF06682.12 CDI78896.1 - 0.0017 18.1 0.0 0.0017 18.1 0.0 3.1 1 1 2 3 3 2 2 SOCE-associated regulatory factor of calcium homoeostasis GREB1 PF15782.5 CDI78896.1 - 0.0039 14.4 37.8 0.018 12.2 13.2 2.1 2 0 0 2 2 2 2 Gene regulated by oestrogen in breast cancer Zip PF02535.22 CDI78896.1 - 0.0053 16.0 2.8 0.0053 16.0 2.8 2.7 2 1 0 2 2 1 1 ZIP Zinc transporter Ndc1_Nup PF09531.10 CDI78896.1 - 0.0054 15.5 29.9 0.093 11.4 8.4 2.1 2 0 0 2 2 2 2 Nucleoporin protein Ndc1-Nup Ge1_WD40 PF16529.5 CDI78896.1 - 0.011 14.7 0.0 0.011 14.7 0.0 1.8 2 0 0 2 2 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SPX PF03105.19 CDI78896.1 - 0.011 15.6 35.7 0.074 13.0 15.8 2.3 2 0 0 2 2 2 0 SPX domain ANAPC4_WD40 PF12894.7 CDI78896.1 - 0.048 14.0 0.0 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Presenilin PF01080.17 CDI78896.1 - 1.2 7.8 43.0 1.3 7.7 9.8 2.1 2 0 0 2 2 2 0 Presenilin Peptidase_U57 PF05582.12 CDI78896.1 - 1.5 8.0 13.7 0.68 9.1 0.1 2.4 2 0 0 2 2 2 0 YabG peptidase U57 eIF3_subunit PF08597.10 CDI78896.1 - 2 8.3 24.9 1 9.2 10.4 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Cwf_Cwc_15 PF04889.12 CDI78896.1 - 2.5 7.8 32.4 0.22 11.2 14.1 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SpoVR PF04293.13 CDI78896.1 - 3.6 6.2 11.4 0.93 8.1 6.1 2.0 2 0 0 2 2 2 0 SpoVR like protein Nop14 PF04147.12 CDI78896.1 - 6 5.0 24.1 4.3 5.4 2.6 2.0 2 0 0 2 2 2 0 Nop14-like family DAG_kinase_N PF14513.6 CDI78896.1 - 6.3 7.0 33.5 4.6 7.4 7.8 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus MMR1 PF08505.10 CDI78896.1 - 8.7 6.5 48.8 1.2 9.3 22.9 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein CDC45 PF02724.14 CDI78896.1 - 9.7 4.3 25.1 3.8 5.7 0.7 2.2 2 0 0 2 2 2 0 CDC45-like protein D5_N PF08706.11 CDI78897.1 - 0.71 10.1 2.7 1.5 9.1 2.7 1.4 1 0 0 1 1 1 0 D5 N terminal like Antimicrobial_4 PF08024.11 CDI78898.1 - 0.91 9.7 8.8 93 3.2 0.2 4.7 4 0 0 4 4 4 0 Ant antimicrobial peptide Peptidase_Prp PF04327.12 CDI78901.1 - 4.6 7.6 8.9 1.5 9.1 1.1 4.0 3 0 0 3 3 3 0 Cysteine protease Prp SUIM_assoc PF16619.5 CDI78901.1 - 6.4 6.9 0.0 1.1 9.4 4.8 24.6 19 4 4 23 23 23 0 Unstructured region C-term to UIM in Ataxin3 Methyltransf_31 PF13847.6 CDI78906.1 - 1.4e-06 28.2 0.0 4.9e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI78906.1 - 2.1e-06 28.4 0.0 2.8e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI78906.1 - 4.5e-06 27.2 0.0 0.00015 22.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI78906.1 - 0.0002 22.0 0.0 0.00084 20.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain RskA PF10099.9 CDI78907.1 - 0.018 15.4 14.9 0.018 15.4 14.9 5.4 1 1 2 4 4 4 0 Anti-sigma-K factor rskA LRR_8 PF13855.6 CDI78908.1 - 2.8e-06 27.0 1.9 0.0072 16.1 0.1 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDI78908.1 - 3.1e-06 27.4 0.8 0.00068 20.0 0.9 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDI78908.1 - 0.00084 19.2 0.7 0.29 11.3 0.0 2.8 3 0 0 3 3 2 1 Leucine Rich repeat RskA PF10099.9 CDI78908.1 - 0.0016 18.7 4.9 0.0031 17.8 4.9 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA FHIPEP PF00771.20 CDI78908.1 - 0.013 14.0 1.6 0.016 13.7 1.6 1.0 1 0 0 1 1 1 0 FHIPEP family TFIIA PF03153.13 CDI78908.1 - 0.014 15.4 11.9 0.022 14.8 11.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI78908.1 - 0.27 9.4 11.4 0.36 9.1 11.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4407 PF14362.6 CDI78908.1 - 0.45 9.8 5.4 0.6 9.4 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TERB2 PF15101.6 CDI78908.1 - 0.91 9.5 6.7 1.4 8.9 6.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Ndc1_Nup PF09531.10 CDI78908.1 - 1.3 7.6 8.1 1.9 7.1 8.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup WRNPLPNID PF15017.6 CDI78908.1 - 1.4 9.8 10.8 3.4 8.6 1.9 3.2 3 1 0 3 3 3 0 Putative WW-binding domain and destruction box Suf PF05843.14 CDI78908.1 - 4.2 7.3 9.0 7.1 6.5 9.0 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI78908.1 - 8.3 5.1 8.4 12 4.5 8.4 1.3 1 0 0 1 1 1 0 Presenilin Med3 PF11593.8 CDI78908.1 - 8.5 5.4 19.3 13 4.8 19.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal GREB1 PF15782.5 CDI78909.1 - 5.4 4.0 36.4 6.1 3.8 36.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PNISR PF15996.5 CDI78909.1 - 7.4 6.8 49.6 9.5 6.4 49.6 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Pkinase PF00069.25 CDI78910.1 - 6.1e-19 68.4 9.9 8.3e-06 25.4 0.0 5.6 5 1 0 5 5 5 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78910.1 - 5.6e-05 22.6 0.0 5.6e-05 22.6 0.0 3.1 3 0 0 3 3 3 1 Protein tyrosine kinase EF-hand_7 PF13499.6 CDI78911.1 - 0.069 13.6 0.0 0.088 13.3 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair RskA PF10099.9 CDI78912.1 - 7.5e-05 23.1 4.9 7.5e-05 23.1 4.9 20.5 9 5 5 15 15 15 6 Anti-sigma-K factor rskA GTP_EFTU PF00009.27 CDI78914.1 - 2.8e-23 82.5 0.1 2.2e-22 79.5 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CDI78914.1 - 7.4e-09 35.7 0.1 4e-07 30.1 0.1 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 CDI78914.1 - 5.9e-05 23.1 0.0 0.00035 20.6 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CDI78914.1 - 0.02 14.6 0.2 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 CDI78914.1 - 0.029 14.4 0.0 0.27 11.3 0.0 2.1 2 0 0 2 2 2 0 Dynamin family Pkinase PF00069.25 CDI78916.1 - 2.2e-17 63.3 0.0 3.8e-17 62.5 0.0 4.1 2 2 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI78916.1 - 1.8e-07 30.7 0.0 1.8e-07 30.7 0.0 2.5 2 1 1 3 3 3 1 Protein tyrosine kinase Pex16 PF08610.10 CDI78916.1 - 0.051 12.7 7.5 0.1 11.7 7.5 1.6 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) CobT PF06213.12 CDI78916.1 - 0.32 10.3 62.1 0.1 12.0 9.3 3.4 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT SpoIIP PF07454.11 CDI78916.1 - 1.6 8.1 47.1 0.12 11.9 8.2 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) DUF4834 PF16118.5 CDI78916.1 - 6 7.9 51.7 0.53 11.3 8.5 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) COG2 PF06148.11 CDI78917.1 - 0.024 14.7 2.6 0.024 14.7 2.6 3.3 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Nha1_C PF08619.10 CDI78917.1 - 3.4 6.8 32.5 5 6.2 32.5 1.2 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Auxin_canalis PF05703.11 CDI78917.1 - 5.3 6.9 23.6 8.3 6.3 23.6 1.3 1 0 0 1 1 1 0 Auxin canalisation PAT1 PF09770.9 CDI78917.1 - 6.2 5.0 46.9 6.4 4.9 46.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CRT10 PF08728.10 CDI78917.1 - 7.6 4.6 18.3 7.8 4.5 18.3 1.0 1 0 0 1 1 1 0 CRT10 BAF1_ABF1 PF04684.13 CDI78917.1 - 8.8 5.3 29.5 11 5.0 29.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF1645 PF07816.11 CDI78918.1 - 0.15 12.6 20.2 0.17 12.4 20.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Spt20 PF12090.8 CDI78918.1 - 0.33 10.5 15.6 0.44 10.1 15.6 1.2 1 0 0 1 1 1 0 Spt20 family Macoilin PF09726.9 CDI78918.1 - 1.7 7.1 21.1 1.9 7.0 21.1 1.0 1 0 0 1 1 1 0 Macoilin family Roughex PF06020.11 CDI78918.1 - 1.8 7.6 8.9 1.8 7.6 8.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Apt1 PF10351.9 CDI78918.1 - 8.1 5.2 19.8 8.5 5.1 19.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain PT PF04886.12 CDI78919.1 - 0.0046 16.5 0.2 0.0046 16.5 0.2 4.1 3 0 0 3 3 3 1 PT repeat DUF3827 PF12877.7 CDI78919.1 - 0.68 8.2 7.8 0.99 7.7 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) BAF1_ABF1 PF04684.13 CDI78920.1 - 0.0064 15.6 8.5 0.0064 15.6 8.5 2.2 3 0 0 3 3 3 1 BAF1 / ABF1 chromatin reorganising factor SARAF PF06682.12 CDI78920.1 - 0.0086 15.8 8.9 0.0086 15.8 8.9 2.1 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Ureide_permease PF07168.11 CDI78920.1 - 0.046 12.5 3.8 0.1 11.3 3.8 1.6 1 0 0 1 1 1 0 Ureide permease CLN3 PF02487.17 CDI78920.1 - 0.048 12.7 4.8 0.084 11.9 4.8 1.4 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 CDI78920.1 - 0.079 12.7 4.4 0.14 11.9 4.4 1.4 1 0 0 1 1 1 0 Connexin Hid1 PF12722.7 CDI78920.1 - 0.12 10.5 6.0 0.15 10.2 6.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF913 PF06025.12 CDI78920.1 - 0.21 10.5 5.4 0.39 9.6 5.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Serinc PF03348.15 CDI78920.1 - 0.22 10.4 4.1 0.35 9.8 4.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) SpoVR PF04293.13 CDI78920.1 - 0.29 9.8 10.0 0.47 9.1 10.0 1.2 1 0 0 1 1 1 0 SpoVR like protein Peptidase_S64 PF08192.11 CDI78920.1 - 0.34 9.4 8.7 0.02 13.4 3.8 1.4 2 0 0 2 2 2 0 Peptidase family S64 SID-1_RNA_chan PF13965.6 CDI78920.1 - 0.35 9.2 2.2 0.48 8.8 2.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 O-antigen_lig PF13425.6 CDI78920.1 - 0.61 8.8 2.1 0.8 8.4 2.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PglZ PF08665.12 CDI78920.1 - 0.62 10.1 7.2 0.039 14.0 2.0 1.6 2 0 0 2 2 1 0 PglZ domain SLC12 PF03522.15 CDI78920.1 - 0.63 9.0 10.0 0.022 13.8 4.5 1.4 2 0 0 2 2 2 0 Solute carrier family 12 DUF4366 PF14283.6 CDI78920.1 - 0.79 9.8 9.4 0.71 9.9 4.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Neur_chan_memb PF02932.16 CDI78920.1 - 0.86 9.6 8.1 0.24 11.4 5.1 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ribonuc_P_40 PF08584.11 CDI78920.1 - 1.1 8.5 6.8 1.8 7.7 6.8 1.3 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit Presenilin PF01080.17 CDI78920.1 - 1.4 7.6 15.3 0.18 10.6 11.1 1.5 2 0 0 2 2 2 0 Presenilin FxsA PF04186.13 CDI78920.1 - 1.4 9.1 0.0 1.4 9.1 0.0 3.4 3 1 1 4 4 4 0 FxsA cytoplasmic membrane protein PIP5K PF01504.18 CDI78920.1 - 1.7 7.8 8.7 3.2 6.9 8.7 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Lin-8 PF03353.15 CDI78920.1 - 1.7 8.1 17.9 0.047 13.2 11.2 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Endostatin PF06482.11 CDI78920.1 - 1.8 8.0 12.5 0.52 9.7 8.7 1.8 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin DUF1980 PF09323.10 CDI78920.1 - 2 8.3 7.6 0.31 10.9 3.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) FAM60A PF15396.6 CDI78920.1 - 2 8.3 7.9 1.2 9.1 5.7 1.7 2 0 0 2 2 2 0 Protein Family FAM60A ALMT PF11744.8 CDI78920.1 - 5.4 5.7 9.9 9 5.0 9.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter VRR_NUC PF08774.11 CDI78921.1 - 1.1e-14 54.4 12.5 2.2e-14 53.4 4.1 4.0 2 1 0 2 2 2 1 VRR-NUC domain TFIIA PF03153.13 CDI78921.1 - 0.00017 21.7 25.5 0.00017 21.7 25.5 9.0 3 3 1 6 6 6 1 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI78921.1 - 0.0022 18.0 1.3 0.0022 18.0 1.3 17.8 15 2 2 17 17 17 5 Unstructured region C-term to UIM in Ataxin3 CNDH2_C PF16858.5 CDI78921.1 - 0.16 11.8 0.0 0.16 11.8 0.0 8.1 4 2 2 6 6 6 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Profilin PF00235.19 CDI78924.1 - 0.033 14.5 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 Profilin Ribosomal_S11 PF00411.19 CDI78925.1 - 2e-31 108.7 2.2 2.3e-31 108.4 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_S11 PF00411.19 CDI78927.1 - 2.4e-47 159.9 1.5 2.4e-47 159.9 1.5 1.7 2 0 0 2 2 2 1 Ribosomal protein S11 BKACE PF05853.12 CDI78927.1 - 0.026 13.8 0.2 0.026 13.8 0.2 1.5 2 0 0 2 2 2 0 beta-keto acid cleavage enzyme Pilus_CpaD PF09476.10 CDI78927.1 - 0.12 12.0 0.2 0.12 12.0 0.2 1.5 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF3720 PF12517.8 CDI78927.1 - 0.72 10.8 11.5 0.1 13.6 7.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3720) PI3_PI4_kinase PF00454.27 CDI78929.1 - 1.7e-23 83.7 0.0 4.3e-22 79.1 0.0 3.3 3 1 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CDI78929.1 - 6.6e-14 51.4 0.1 1.7e-13 50.2 0.1 1.8 1 0 0 1 1 1 1 FATC domain FRB_dom PF08771.11 CDI78929.1 - 0.049 14.1 0.0 0.049 14.1 0.0 5.0 3 1 0 3 3 3 0 FKBP12-rapamycin binding domain Peptidase_A22B PF04258.13 CDI78931.1 - 4.2e-71 239.8 7.8 4.2e-71 239.8 7.8 1.5 2 0 0 2 2 2 1 Signal peptide peptidase SPP PF06550.11 CDI78931.1 - 2.4 7.6 21.1 0.5 9.8 13.2 2.8 2 1 0 2 2 2 0 Signal-peptide peptidase, presenilin aspartyl protease HEAT PF02985.22 CDI78932.1 - 5e-13 48.1 14.4 0.0026 17.9 0.5 6.5 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 CDI78932.1 - 6.5e-07 29.7 0.5 6.5e-07 29.7 0.5 8.3 8 0 0 8 8 8 2 HEAT repeats Cnd1 PF12717.7 CDI78932.1 - 5.8e-05 23.2 0.0 0.047 13.7 0.0 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Pkinase PF00069.25 CDI78932.1 - 0.00057 19.3 0.0 0.00057 19.3 0.0 3.0 3 1 0 3 3 3 1 Protein kinase domain TFIIA PF03153.13 CDI78932.1 - 0.0047 17.0 10.5 0.0047 17.0 10.5 8.7 6 2 1 7 7 7 3 Transcription factor IIA, alpha/beta subunit Mem_trans PF03547.18 CDI78932.1 - 0.0065 14.9 8.4 0.081 11.3 0.1 3.6 3 0 0 3 3 3 1 Membrane transport protein DUF3385 PF11865.8 CDI78932.1 - 5.2 6.9 0.0 5.2 6.9 0.0 4.7 5 1 0 5 5 5 0 Domain of unknown function (DUF3385) DDHD PF02862.17 CDI78932.1 - 5.5 7.1 54.8 0.088 13.0 3.5 7.0 7 0 0 7 7 7 0 DDHD domain Connexin PF00029.19 CDI78932.1 - 6.5 6.4 40.6 0.0066 16.2 7.1 4.6 4 0 0 4 4 4 0 Connexin His_Phos_2 PF00328.22 CDI78935.1 - 1.5e-41 143.0 31.2 9.2e-27 94.4 0.1 6.5 5 1 1 6 6 6 5 Histidine phosphatase superfamily (branch 2) RimK PF08443.11 CDI78935.1 - 0.00015 21.4 0.0 0.00037 20.1 0.0 1.6 1 0 0 1 1 1 1 RimK-like ATP-grasp domain RskA PF10099.9 CDI78936.1 - 0.0042 17.4 5.9 0.0042 17.4 5.9 20.3 5 3 9 14 14 14 2 Anti-sigma-K factor rskA EamA PF00892.20 CDI78937.1 - 1.5e-05 25.2 37.2 2.2e-05 24.6 10.5 3.6 3 0 0 3 3 3 3 EamA-like transporter family DUF4834 PF16118.5 CDI78937.1 - 1.6 9.7 3.1 26 5.8 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) D123 PF07065.14 CDI78938.1 - 6.8e-14 51.7 0.8 6.8e-14 51.7 0.8 6.7 5 2 0 5 5 5 1 D123 Lin-8 PF03353.15 CDI78938.1 - 1.6e-06 27.9 10.7 1.6e-06 27.9 10.7 4.7 4 1 0 4 4 4 2 Ras-mediated vulval-induction antagonist SAPS PF04499.15 CDI78938.1 - 0.00061 18.7 11.9 0.00061 18.7 11.9 2.7 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein TCP PF03634.13 CDI78938.1 - 0.00069 20.2 14.0 0.00069 20.2 14.0 5.9 6 1 0 6 6 6 3 TCP family transcription factor RskA PF10099.9 CDI78938.1 - 0.0013 19.1 0.0 0.0013 19.1 0.0 7.2 4 3 1 6 6 6 1 Anti-sigma-K factor rskA CDC45 PF02724.14 CDI78938.1 - 0.0018 16.7 15.1 0.0018 16.7 15.1 3.5 4 0 0 4 4 4 1 CDC45-like protein SPX PF03105.19 CDI78938.1 - 0.0033 17.4 41.1 47 3.7 8.2 4.3 2 1 0 2 2 2 0 SPX domain RRM_1 PF00076.22 CDI78939.1 - 2.7e-24 84.8 0.2 3e-11 43.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI78939.1 - 3.5e-10 39.9 0.0 0.0015 18.6 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif zf-RING_UBOX PF13445.6 CDI78940.1 - 1.7e-07 31.1 12.3 6.6e-07 29.3 12.3 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDI78940.1 - 1.7e-06 27.7 13.3 5.3e-06 26.2 13.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI78940.1 - 2e-06 27.6 10.7 4.9e-06 26.3 10.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI78940.1 - 2.1e-06 28.0 12.9 7.1e-06 26.3 12.9 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 CDI78940.1 - 3.4e-06 27.1 14.6 3.4e-06 27.1 14.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CDI78940.1 - 1.3e-05 25.0 13.7 3.3e-05 23.6 13.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FHA PF00498.26 CDI78940.1 - 1.5e-05 25.2 0.0 0.00013 22.2 0.0 2.4 2 0 0 2 2 2 1 FHA domain Macoilin PF09726.9 CDI78940.1 - 0.00035 19.3 20.4 0.00035 19.3 20.4 4.3 4 1 0 4 4 3 1 Macoilin family Prok-RING_4 PF14447.6 CDI78940.1 - 0.0014 18.4 11.1 0.0014 18.4 11.1 2.9 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CDI78940.1 - 0.0023 17.7 3.0 0.0074 16.1 3.0 1.9 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CDI78940.1 - 0.0055 17.0 8.9 0.034 14.4 8.9 2.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CDI78940.1 - 0.0057 16.6 12.3 0.023 14.7 12.4 2.1 1 1 0 1 1 1 1 zinc-RING finger domain Rad50_zn_hook PF04423.14 CDI78940.1 - 0.066 13.1 0.2 0.2 11.5 0.2 1.8 1 0 0 1 1 1 0 Rad50 zinc hook motif U-box PF04564.15 CDI78940.1 - 0.072 13.3 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-RING_10 PF16685.5 CDI78940.1 - 0.11 12.6 9.5 0.23 11.6 9.5 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.8 CDI78940.1 - 0.18 11.7 5.4 0.4 10.5 5.4 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit SpoIIP PF07454.11 CDI78940.1 - 0.21 11.0 7.5 0.65 9.4 7.5 1.8 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3223 PF11523.8 CDI78941.1 - 3.4e-16 59.9 0.8 8.4e-16 58.6 0.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3223) La PF05383.17 CDI78941.1 - 2.9e-12 46.4 0.0 8.2e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 La domain baeRF_family3 PF18845.1 CDI78941.1 - 0.24 11.7 3.4 0.25 11.6 1.3 2.2 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 Retinal PF15449.6 CDI78942.1 - 4.6 4.9 9.5 6.3 4.5 9.5 1.1 1 0 0 1 1 1 0 Retinal protein SSDP PF04503.13 CDI78943.1 - 0.0011 19.4 1.6 0.0012 19.2 1.6 1.1 1 0 0 1 1 1 1 Single-stranded DNA binding protein, SSDP BAF1_ABF1 PF04684.13 CDI78943.1 - 0.27 10.2 6.2 0.4 9.7 6.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Suf PF05843.14 CDI78943.1 - 0.28 11.1 5.6 0.29 11.1 5.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI78943.1 - 0.5 10.3 21.8 0.59 10.1 21.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PsaN PF05479.11 CDI78943.1 - 1.2 9.3 8.1 1.3 9.2 7.6 1.3 1 1 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Spt20 PF12090.8 CDI78943.1 - 3.8 7.1 18.8 4.6 6.8 18.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF1180 PF06679.12 CDI78943.1 - 5.7 7.3 8.0 8.2 6.8 8.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) Presenilin PF01080.17 CDI78943.1 - 6.4 5.4 7.0 6.8 5.3 7.0 1.1 1 0 0 1 1 1 0 Presenilin zf-rbx1 PF12678.7 CDI78944.1 - 1.7e-08 34.6 2.8 4e-08 33.4 2.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDI78944.1 - 1.5e-05 25.2 6.0 1.5e-05 25.2 6.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 CDI78944.1 - 0.00017 21.6 0.6 0.00034 20.6 0.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 CDI78944.1 - 0.00074 19.3 0.9 0.0016 18.3 0.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI78944.1 - 0.00087 19.1 5.2 0.002 17.9 5.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI78944.1 - 0.0054 16.7 0.5 0.014 15.4 0.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI78944.1 - 0.013 15.4 2.3 0.034 14.1 2.3 1.7 1 0 0 1 1 1 0 zinc-RING finger domain SUIM_assoc PF16619.5 CDI78944.1 - 0.11 12.6 31.2 0.04 14.0 6.0 3.9 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 zf-RING_11 PF17123.5 CDI78944.1 - 2.5 7.9 9.6 0.04 13.7 2.4 1.7 2 0 0 2 2 2 0 RING-like zinc finger PGAP1 PF07819.13 CDI78946.1 - 5.9e-09 36.0 0.0 2.2e-08 34.1 0.0 2.0 1 0 0 1 1 1 1 PGAP1-like protein DUF2722 PF10846.8 CDI78946.1 - 0.00038 19.5 3.2 0.00038 19.5 3.2 10.0 9 2 0 9 9 9 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI78946.1 - 0.0044 16.7 2.5 0.0044 16.7 2.5 9.5 9 2 0 9 9 9 4 Spt20 family Dpy19 PF10034.9 CDI78946.1 - 5.5 5.1 8.0 2.1 6.5 0.1 2.8 3 0 0 3 3 3 0 Q-cell neuroblast polarisation DAP10 PF07213.11 CDI78947.1 - 0.033 14.1 2.8 1.6 8.7 0.0 2.9 3 0 0 3 3 3 0 DAP10 membrane protein Sensor_TM1 PF13755.6 CDI78947.1 - 0.3 10.8 1.0 94 2.8 0.0 3.1 3 0 0 3 3 3 0 Sensor N-terminal transmembrane domain Chorismate_synt PF01264.21 CDI78950.1 - 9.1e-61 205.4 0.0 4.4e-43 147.2 0.0 2.3 1 1 1 2 2 2 2 Chorismate synthase DUF2514 PF10721.9 CDI78950.1 - 0.38 10.8 32.3 1.8 8.5 24.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) SWI-SNF_Ssr4 PF08549.10 CDI78950.1 - 5.8 5.4 7.8 8.1 5.0 7.8 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RskA PF10099.9 CDI78950.1 - 6.5 7.0 29.3 3.2 8.0 0.2 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA YppG PF14179.6 CDI78951.1 - 1.9 9.2 20.5 0.16 12.7 15.0 2.1 2 0 0 2 2 2 0 YppG-like protein PAM2 PF07145.15 CDI78952.1 - 9e-05 21.9 1.4 0.00022 20.7 1.4 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region SUIM_assoc PF16619.5 CDI78952.1 - 0.0017 18.4 1.4 0.0017 18.4 1.4 11.5 7 2 2 9 9 9 2 Unstructured region C-term to UIM in Ataxin3 N6_N4_Mtase PF01555.18 CDI78952.1 - 0.0039 16.9 0.0 76 2.9 8.2 3.2 4 2 0 5 5 5 0 DNA methylase RskA PF10099.9 CDI78953.1 - 0.0035 17.7 1.9 0.0035 17.7 1.9 10.6 2 1 2 4 4 4 1 Anti-sigma-K factor rskA BHD_3 PF10405.9 CDI78957.1 - 1.2e-06 28.9 0.0 2.6e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 CDI78957.1 - 4.9e-06 26.3 0.1 4.9e-06 26.3 0.1 4.4 3 0 0 3 3 3 2 Rad4 transglutaminase-like domain DUF2722 PF10846.8 CDI78957.1 - 0.0016 17.4 9.3 0.0016 17.4 9.3 10.7 8 3 1 10 10 10 1 Protein of unknown function (DUF2722) Transglut_core PF01841.19 CDI78957.1 - 0.022 15.2 0.0 0.022 15.2 0.0 3.9 4 0 0 4 4 4 0 Transglutaminase-like superfamily RAP PF08373.10 CDI78958.1 - 0.00057 19.9 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 RAP domain Spt20 PF12090.8 CDI78958.1 - 0.0041 16.8 1.6 0.0041 16.8 1.6 9.3 7 1 1 8 8 8 4 Spt20 family Sec63 PF02889.16 CDI78959.1 - 4.8e-107 356.9 0.0 3.6e-43 147.6 0.0 4.0 2 2 0 3 3 3 3 Sec63 Brl domain DEAD PF00270.29 CDI78959.1 - 2.4e-17 63.2 0.1 3.6e-09 36.6 0.0 2.9 2 0 0 2 2 2 2 DEAD/DEAH box helicase UPF0086 PF01868.16 CDI78959.1 - 2.1e-07 30.7 0.0 4.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Helicase_C PF00271.31 CDI78959.1 - 7.7e-07 29.5 0.0 3.6e-05 24.1 0.0 3.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDI78959.1 - 1.9e-05 25.0 0.8 0.11 12.7 0.0 3.9 2 1 0 2 2 2 2 AAA domain ResIII PF04851.15 CDI78959.1 - 0.013 15.6 3.3 2.2 8.3 0.0 3.3 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit SAM_3 PF18016.1 CDI78959.1 - 0.029 14.2 1.9 4.6 7.1 0.1 3.1 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) DUF2235 PF09994.9 CDI78959.1 - 0.061 12.7 0.9 0.21 10.9 0.9 1.9 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF3997 PF13162.6 CDI78961.1 - 0.096 13.0 0.6 0.26 11.6 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3997) Methyltransf_15 PF09445.10 CDI78962.1 - 7.2e-10 38.7 1.4 2.9e-05 23.7 0.0 2.9 3 0 0 3 3 3 2 RNA cap guanine-N2 methyltransferase EPL1 PF10513.9 CDI78962.1 - 0.0022 18.4 10.3 0.42 11.0 4.2 3.3 3 1 0 3 3 3 1 Enhancer of polycomb-like TFIIA PF03153.13 CDI78962.1 - 0.0052 16.8 40.8 0.058 13.4 18.7 3.1 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI78962.1 - 0.0066 16.1 38.2 0.025 14.2 19.7 2.5 2 0 0 2 2 2 2 Spt20 family DDHD PF02862.17 CDI78962.1 - 0.52 10.4 13.1 2.9 8.0 1.4 3.3 3 0 0 3 3 3 0 DDHD domain MDD_C PF18376.1 CDI78962.1 - 0.59 9.8 2.3 0.94 9.2 0.1 2.1 2 0 0 2 2 2 0 Mevalonate 5-diphosphate decarboxylase C-terminal domain eIF_4EBP PF05456.11 CDI78962.1 - 1.6 8.7 9.9 6.9 6.6 2.5 2.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Ndc1_Nup PF09531.10 CDI78962.1 - 4.1 6.0 21.0 0.17 10.5 8.4 3.0 3 0 0 3 3 3 0 Nucleoporin protein Ndc1-Nup U1snRNP70_N PF12220.8 CDI78962.1 - 4.9 7.9 12.8 3.4 8.4 3.5 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4770 PF15994.5 CDI78962.1 - 6.3 7.0 16.5 1.4 9.1 5.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Sec62 PF03839.16 CDI78962.1 - 7.7 5.9 7.1 8.3 5.9 0.5 2.5 2 0 0 2 2 2 0 Translocation protein Sec62 AMA-1 PF02430.15 CDI78963.1 - 8.8e-06 24.9 0.1 1.1e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Apical membrane antigen 1 DUF4366 PF14283.6 CDI78963.1 - 0.0029 17.7 0.4 0.0051 16.9 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) DUF3042 PF11240.8 CDI78963.1 - 0.13 12.3 0.7 0.35 10.9 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) ETRAMP PF09716.10 CDI78963.1 - 0.77 9.9 5.0 0.1 12.7 0.7 1.9 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) COX2 PF00116.20 CDI78964.1 - 0.0026 17.6 0.4 0.0047 16.8 0.1 1.6 2 0 0 2 2 2 1 Cytochrome C oxidase subunit II, periplasmic domain zf-CCCH_4 PF18044.1 CDI78965.1 - 3.9 7.4 5.8 8.9 6.2 5.8 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger AMP-binding PF00501.28 CDI78967.1 - 1.6e-12 46.7 0.1 0.0001 21.1 0.0 3.3 3 0 0 3 3 3 3 AMP-binding enzyme tRNA-synt_2b PF00587.25 CDI78968.1 - 2.9e-13 50.2 0.0 3.6e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) WD40 PF00400.32 CDI78969.1 - 1.2e-05 25.9 3.1 0.0084 16.9 0.2 5.0 6 0 0 6 6 6 2 WD domain, G-beta repeat DHC_N1 PF08385.12 CDI78970.1 - 3.4e-105 352.8 16.9 1.6e-104 350.6 6.1 4.0 4 0 0 4 4 4 2 Dynein heavy chain, N-terminal region 1 Vps54 PF07928.12 CDI78970.1 - 0.081 13.4 0.2 1.3 9.5 0.0 3.0 2 0 0 2 2 2 0 Vps54-like protein RHH_4 PF13467.6 CDI78970.1 - 0.11 12.4 0.5 3.4 7.6 0.1 2.6 2 0 0 2 2 2 0 Ribbon-helix-helix domain Sec34 PF04136.15 CDI78970.1 - 0.16 11.8 10.5 1.3 8.9 0.1 4.2 4 0 0 4 4 4 0 Sec34-like family RecG_N PF17190.4 CDI78970.1 - 3.3 8.5 9.2 0.48 11.2 0.7 3.8 4 0 0 4 4 4 0 RecG N-terminal helical domain AAA_6 PF12774.7 CDI78971.1 - 3.3e-145 483.1 0.0 6.4e-145 482.2 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 CDI78971.1 - 4.7e-85 285.1 0.0 1.3e-84 283.6 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 DHC_N2 PF08393.13 CDI78971.1 - 4.8e-79 266.3 1.0 4.8e-79 266.3 1.0 3.4 4 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 CDI78971.1 - 1.8e-67 226.4 0.5 6.3e-61 205.0 0.0 3.7 3 0 0 3 3 3 2 P-loop containing dynein motor region Dynein_C PF18199.1 CDI78971.1 - 5.2e-55 186.8 0.0 5.5e-53 180.2 0.0 2.8 1 1 1 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 CDI78971.1 - 1.2e-51 175.8 9.6 1.9e-51 175.1 9.6 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 CDI78971.1 - 1.9e-48 164.3 0.0 4.1e-48 163.3 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_9 PF12781.7 CDI78971.1 - 3.1e-37 127.8 15.7 5.9e-32 110.6 0.2 3.6 2 1 1 3 3 2 2 ATP-binding dynein motor region AAA_5 PF07728.14 CDI78971.1 - 2.4e-22 79.4 0.0 2.8e-05 24.1 0.0 6.0 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDI78971.1 - 1.7e-17 63.7 2.0 2e-17 63.5 0.0 2.2 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI78971.1 - 3.8e-17 62.3 0.0 1.2e-16 60.7 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain Dynein_heavy PF03028.15 CDI78971.1 - 1.4e-11 44.5 0.0 5.8e-11 42.5 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 CDI78971.1 - 1.2e-06 28.8 0.9 0.47 10.7 0.0 4.5 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 CDI78971.1 - 6.6e-06 26.6 10.1 1.4 9.3 0.0 6.3 7 0 0 7 7 5 2 AAA ATPase domain AAA PF00004.29 CDI78971.1 - 5.4e-05 23.6 2.0 0.2 12.1 0.0 4.8 6 0 0 6 6 4 1 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 CDI78971.1 - 0.0034 16.8 0.1 1.8 7.8 0.0 3.2 3 0 0 3 3 3 1 FtsK/SpoIIIE family Sigma54_activat PF00158.26 CDI78971.1 - 0.0083 15.8 0.0 5.6 6.6 0.0 3.3 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_30 PF13604.6 CDI78971.1 - 0.0098 15.6 1.2 3.2 7.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDI78971.1 - 0.027 15.0 10.0 0.32 11.5 0.0 5.1 6 0 0 6 6 4 0 AAA domain AAA_28 PF13521.6 CDI78971.1 - 0.075 13.3 3.8 3.7 7.8 0.0 3.5 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 CDI78971.1 - 0.075 13.4 0.0 18 5.8 0.0 3.5 3 0 0 3 3 3 0 RNA helicase AAA_29 PF13555.6 CDI78971.1 - 0.097 12.4 0.5 13 5.6 0.0 3.5 3 0 0 3 3 3 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI78971.1 - 0.15 11.9 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase sCache_2 PF17200.4 CDI78971.1 - 0.28 11.0 1.2 1.2 9.0 1.2 2.1 1 0 0 1 1 1 0 Single Cache domain 2 Spc7 PF08317.11 CDI78971.1 - 0.55 9.1 26.6 0.041 12.8 7.0 3.0 3 0 0 3 3 3 0 Spc7 kinetochore protein AAA_13 PF13166.6 CDI78971.1 - 0.65 8.6 17.1 0.21 10.2 5.9 2.2 2 0 0 2 2 2 0 AAA domain DUF4407 PF14362.6 CDI78971.1 - 1.6 8.0 16.4 2.8 7.2 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) THOC7 PF05615.13 CDI78971.1 - 2.4 8.5 19.7 16 5.8 3.1 4.0 3 0 0 3 3 3 0 Tho complex subunit 7 RNA_pol_Rpb1_1 PF04997.12 CDI78971.1 - 8.3 5.6 7.7 3.5 6.9 0.0 3.1 3 0 0 3 3 3 0 RNA polymerase Rpb1, domain 1 Ran_BP1 PF00638.18 CDI78972.1 - 1.4e-37 128.7 3.1 1.4e-37 128.7 3.1 1.7 2 0 0 2 2 2 1 RanBP1 domain WH1 PF00568.23 CDI78972.1 - 0.014 15.3 3.2 0.053 13.5 3.2 1.8 1 1 0 1 1 1 0 WH1 domain NAD_binding_11 PF14833.6 CDI78973.1 - 7.2e-32 110.2 0.0 7.2e-32 110.2 0.0 2.2 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 CDI78973.1 - 4.1e-22 79.0 1.5 4.8e-08 33.3 0.0 3.3 1 1 2 3 3 3 3 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CDI78973.1 - 0.00035 21.1 1.0 0.21 12.2 0.1 2.6 1 1 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CDI78973.1 - 0.022 14.6 0.3 0.06 13.2 0.3 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Androgen_recep PF02166.16 CDI78973.1 - 0.03 13.2 10.8 0.046 12.6 10.8 1.2 1 0 0 1 1 1 0 Androgen receptor Ribosomal_60s PF00428.19 CDI78973.1 - 6.9 7.3 9.1 18 6.0 3.1 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF572 PF04502.13 CDI78974.1 - 0.27 10.8 27.5 0.36 10.4 27.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI78974.1 - 0.8 9.6 24.8 1.1 9.2 24.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Auto_anti-p27 PF06677.12 CDI78975.1 - 3.7e-16 59.0 3.0 7.1e-16 58.1 3.0 1.5 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF4551 PF15087.6 CDI78975.1 - 0.29 9.9 22.0 0.41 9.4 22.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RICTOR_N PF14664.6 CDI78975.1 - 0.53 9.2 12.1 0.061 12.3 2.5 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term TRAP_alpha PF03896.16 CDI78975.1 - 0.57 9.3 10.3 0.21 10.8 2.2 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit RXT2_N PF08595.11 CDI78975.1 - 0.84 9.6 15.2 1.9 8.5 5.1 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF2126 PF09899.9 CDI78975.1 - 0.95 7.5 12.5 0.86 7.6 0.6 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) ATP11 PF06644.11 CDI78975.1 - 1.1 8.9 28.2 0.43 10.3 12.8 2.1 2 0 0 2 2 2 0 ATP11 protein Caldesmon PF02029.15 CDI78975.1 - 2.8 6.6 30.7 3.4 6.3 30.7 1.0 1 0 0 1 1 1 0 Caldesmon DUF3537 PF12056.8 CDI78975.1 - 2.9 6.6 12.0 0.66 8.7 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) DUF4407 PF14362.6 CDI78975.1 - 3.5 6.9 30.5 5.8 6.2 30.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LAP1C PF05609.12 CDI78975.1 - 6.5 5.7 29.1 8.1 5.4 29.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF1943 PF09172.11 CDI78975.1 - 8.5 5.5 13.9 0.76 9.0 2.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) AP2 PF00847.20 CDI78976.1 - 2.5e-10 40.4 0.4 2.5e-10 40.4 0.4 2.5 2 0 0 2 2 2 1 AP2 domain DUF572 PF04502.13 CDI78977.1 - 0.0024 17.6 7.1 0.0034 17.1 7.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF572) Borrelia_orfA PF02414.15 CDI78977.1 - 0.055 13.1 2.6 0.086 12.5 2.6 1.2 1 0 0 1 1 1 0 Borrelia ORF-A UPF0489 PF12640.7 CDI78977.1 - 0.093 13.0 0.3 0.093 13.0 0.3 1.5 2 0 0 2 2 2 0 UPF0489 domain Glyco_transf_18 PF15024.6 CDI78977.1 - 0.29 9.7 4.6 0.5 8.9 4.6 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 18 Peptidase_C6 PF00851.18 CDI78977.1 - 5.8 5.7 9.2 8 5.3 9.2 1.0 1 0 0 1 1 1 0 Helper component proteinase Spt20 PF12090.8 CDI78978.1 - 0.0061 16.2 5.4 0.0061 16.2 5.4 9.5 5 3 3 8 8 8 1 Spt20 family Suf PF05843.14 CDI78979.1 - 0.026 14.5 3.0 0.032 14.2 3.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RskA PF10099.9 CDI78979.1 - 0.54 10.5 22.3 0.82 9.9 11.7 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI78979.1 - 1.1 8.2 19.5 1.7 7.5 18.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Tic110 PF16940.5 CDI78979.1 - 6.6 5.1 6.5 8.5 4.7 6.5 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter ANAPC_CDC26 PF10471.9 CDI78979.1 - 6.8 7.6 22.3 5.7 7.8 17.6 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 ubiquitin PF00240.23 CDI78983.1 - 7.1e-07 28.9 0.1 1.7e-06 27.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 CDI78983.1 - 4.2e-05 23.9 0.0 0.00022 21.6 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 CDI78983.1 - 0.033 14.0 0.1 0.15 11.9 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PI3K_rbd PF00794.18 CDI78983.1 - 0.12 12.6 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain UN_NPL4 PF11543.8 CDI78983.1 - 0.16 12.5 0.0 0.2 12.1 0.0 1.3 1 1 0 1 1 1 0 Nuclear pore localisation protein NPL4 WD40 PF00400.32 CDI78986.1 - 8.3e-17 61.3 19.1 9.5e-05 23.1 0.1 7.6 7 1 0 7 7 7 3 WD domain, G-beta repeat PRP4 PF08799.11 CDI78986.1 - 6.5e-12 44.8 1.2 1.7e-11 43.4 1.2 1.8 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 CDI78986.1 - 1.1e-05 25.6 0.0 0.46 10.8 0.0 3.6 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3232 PF11554.8 CDI78986.1 - 0.11 12.8 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3232) DUF4632 PF15451.6 CDI78987.1 - 0.44 10.6 0.1 0.44 10.6 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4632) WD40 PF00400.32 CDI78988.1 - 2.5e-07 31.3 6.0 0.00025 21.8 0.1 5.5 5 0 0 5 5 5 1 WD domain, G-beta repeat Bromodomain PF00439.25 CDI78988.1 - 5.1e-06 26.5 0.0 9.9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Citrate_synt PF00285.21 CDI78989.1 - 6.6e-25 87.9 0.0 9.2e-22 77.6 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 CDI78989.1 - 1.9e-06 27.8 0.0 6.7e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 CoA-ligase NFACT-R_1 PF05670.13 CDI78990.1 - 1.1e-25 90.4 0.0 1.2e-24 87.0 0.0 3.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-C PF11923.8 CDI78990.1 - 3e-14 52.8 0.2 3e-14 52.8 0.2 6.1 6 1 0 6 6 6 1 NFACT protein C-terminal domain FbpA PF05833.11 CDI78990.1 - 1.2e-12 47.4 0.0 1.2e-12 47.4 0.0 8.9 8 2 1 9 9 9 2 Fibronectin-binding protein A N-terminus (FbpA) DUF2339 PF10101.9 CDI78990.1 - 1.5e-05 23.8 28.4 1.5e-05 23.8 28.4 2.9 2 1 0 3 3 3 1 Predicted membrane protein (DUF2339) PRCC PF10253.9 CDI78990.1 - 0.0023 18.7 8.3 0.0023 18.7 8.3 12.2 5 3 2 8 8 8 1 Mitotic checkpoint regulator, MAD2B-interacting Otopetrin PF03189.13 CDI78990.1 - 0.5 9.1 0.0 0.5 9.1 0.0 7.1 5 3 0 5 5 5 0 Otopetrin SR-25 PF10500.9 CDI78991.1 - 0.0013 18.4 10.4 0.0013 18.4 10.4 7.1 6 2 2 8 8 8 2 Nuclear RNA-splicing-associated protein Dapper PF15268.6 CDI78991.1 - 0.0021 17.0 40.0 0.0021 17.0 40.0 4.2 4 0 0 4 4 4 1 Dapper DUF2722 PF10846.8 CDI78991.1 - 0.0086 15.1 0.0 0.0086 15.1 0.0 7.4 4 2 2 6 6 6 2 Protein of unknown function (DUF2722) CAF1 PF04857.20 CDI78991.1 - 5.8 6.0 0.0 5.8 6.0 0.0 4.0 3 2 0 3 3 3 0 CAF1 family ribonuclease Utp14 PF04615.13 CDI78991.1 - 7.7 5.0 65.6 0.48 8.9 3.9 4.0 4 0 0 4 4 4 0 Utp14 protein Sacchrp_dh_NADP PF03435.18 CDI78992.1 - 8.6e-09 35.7 0.0 1.9e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 CDI78992.1 - 0.004 16.6 0.1 2.1 7.8 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase Pox_MCEL PF03291.16 CDI78994.1 - 2e-24 86.3 0.0 4.2e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 CDI78994.1 - 6.8e-11 42.7 0.5 3.1e-10 40.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI78994.1 - 9.5e-10 38.5 0.1 9.5e-10 38.5 0.1 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI78994.1 - 2.9e-08 34.4 0.5 5.5e-07 30.3 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI78994.1 - 1.7e-06 28.6 0.0 6.8e-06 26.6 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI78994.1 - 0.00072 19.4 0.0 0.00072 19.4 0.0 3.2 3 1 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDI78994.1 - 0.0014 18.0 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CDI78994.1 - 0.002 17.5 0.0 0.002 17.5 0.0 2.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 CDI78994.1 - 0.0074 15.9 0.1 0.019 14.6 0.1 1.6 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TPMT PF05724.11 CDI78994.1 - 0.033 13.8 0.6 0.059 13.0 0.0 1.7 2 0 0 2 2 1 0 Thiopurine S-methyltransferase (TPMT) BNIP2 PF12496.8 CDI78994.1 - 0.054 13.9 1.3 0.23 11.9 1.3 2.1 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Methyltransf_9 PF08003.11 CDI78994.1 - 0.33 9.8 0.0 0.33 9.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) DUF2722 PF10846.8 CDI78994.1 - 1 8.2 26.0 0.78 8.6 13.7 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) DUF4820 PF16091.5 CDI78995.1 - 0.00043 19.7 4.8 0.00043 19.7 4.8 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4820) Spt20 PF12090.8 CDI78995.1 - 0.017 14.7 13.3 0.017 14.7 13.3 3.9 4 0 0 4 4 4 0 Spt20 family Sec16 PF12932.7 CDI78995.1 - 0.021 15.4 1.1 0.047 14.3 0.3 2.0 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region SUIM_assoc PF16619.5 CDI78995.1 - 0.025 14.6 4.6 0.025 14.6 4.6 5.0 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 CK_II_beta PF01214.18 CDI78995.1 - 0.12 12.2 1.3 0.67 9.8 0.4 2.3 2 1 0 2 2 2 0 Casein kinase II regulatory subunit Reprolysin_3 PF13582.6 CDI78995.1 - 0.34 11.4 0.0 0.34 11.4 0.0 3.3 3 1 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like DUF4179 PF13786.6 CDI78995.1 - 0.36 11.3 15.6 2.7 8.5 0.0 4.8 3 2 2 5 5 5 0 Domain of unknown function (DUF4179) V_ATPase_I PF01496.19 CDI78995.1 - 1.4 6.7 8.3 2.1 6.2 8.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SDA1 PF05285.12 CDI78995.1 - 7.3 5.9 13.6 24 4.2 4.4 3.1 2 1 0 2 2 2 0 SDA1 PFK PF00365.20 CDI78996.1 - 1.2e-39 136.3 3.1 7.8e-32 110.7 0.0 3.9 2 2 0 2 2 2 2 Phosphofructokinase Activator_LAG-3 PF11498.8 CDI78996.1 - 7.1 5.5 14.9 13 4.6 14.9 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 zf-CCCH_4 PF18044.1 CDI78997.1 - 0.0048 16.7 0.9 0.01 15.6 0.9 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CDI78997.1 - 0.0084 16.1 1.3 0.017 15.2 1.3 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 CDI78997.1 - 0.015 16.0 0.1 0.015 16.0 0.1 3.6 3 0 0 3 3 3 0 Torus domain Nuc_deoxyri_tr2 PF15891.5 CDI78997.1 - 0.063 13.6 0.3 0.063 13.6 0.3 2.5 2 1 0 2 2 1 0 Nucleoside 2-deoxyribosyltransferase like HMw1_D2 PF18254.1 CDI78997.1 - 0.12 12.8 0.1 0.25 11.7 0.1 1.5 1 0 0 1 1 1 0 HMW1 domain 2 zf-CCCH PF00642.24 CDI78997.1 - 0.91 9.5 5.7 0.42 10.6 2.4 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TFB6 PF17110.5 CDI78997.1 - 1 9.1 11.0 1.3 8.7 3.5 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Adenyl_cycl_N PF12633.7 CDI78997.1 - 1.6 8.6 20.7 1.5 8.6 9.7 2.2 2 0 0 2 2 2 0 Adenylate cyclase NT domain Band_3_cyto PF07565.13 CDI78997.1 - 1.9 8.2 25.7 1.1 9.0 15.3 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF1115 PF06544.12 CDI78997.1 - 2.1 8.5 10.9 2.8 8.0 4.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) eIF-3_zeta PF05091.12 CDI78997.1 - 2.8 6.8 27.3 1.9 7.4 14.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Connexin PF00029.19 CDI78997.1 - 3.4 7.4 13.6 7.2 6.3 6.6 2.4 2 0 0 2 2 2 0 Connexin Utp14 PF04615.13 CDI78997.1 - 8.5 4.8 31.3 12 4.3 31.3 1.3 1 0 0 1 1 1 0 Utp14 protein AAA_12 PF13087.6 CDI78999.1 - 2.2e-33 115.6 0.0 4.5e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDI78999.1 - 1.3e-15 57.9 2.1 1.6e-06 28.1 0.0 3.6 3 1 1 4 4 4 2 AAA domain AAA_30 PF13604.6 CDI78999.1 - 6.1e-08 32.6 0.0 2.9e-07 30.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDI78999.1 - 3e-07 30.4 0.1 0.36 10.5 0.0 3.5 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CDI78999.1 - 7.5e-06 26.3 0.0 1.8e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDI78999.1 - 0.024 14.5 0.7 0.12 12.2 0.7 2.3 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 CDI78999.1 - 0.17 12.1 0.0 0.56 10.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF4757 PF15949.5 CDI79000.1 - 0.0021 18.5 4.8 0.0028 18.2 4.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4757) QWRF PF04484.12 CDI79000.1 - 0.14 11.9 9.9 0.16 11.6 9.9 1.1 1 0 0 1 1 1 0 QWRF family Tmemb_cc2 PF10267.9 CDI79000.1 - 0.21 10.7 6.7 0.25 10.5 6.7 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TFIIA PF03153.13 CDI79000.1 - 0.99 9.3 7.3 1.3 8.9 7.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM199X PF15814.5 CDI79000.1 - 1.1 8.3 18.9 1.4 7.9 18.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X SprA-related PF12118.8 CDI79000.1 - 1.2 8.2 12.8 1.8 7.6 12.8 1.4 1 0 0 1 1 1 0 SprA-related family Macoilin PF09726.9 CDI79000.1 - 3.1 6.2 9.4 3.9 5.9 9.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF4342 PF14242.6 CDI79001.1 - 0.02 14.9 0.1 0.02 14.9 0.1 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4342) Cyt_bd_oxida_II PF02322.15 CDI79001.1 - 5.3 6.3 13.1 1.1 8.6 4.6 2.5 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II Spt20 PF12090.8 CDI79003.1 - 0.00021 21.0 5.9 0.00021 21.0 5.9 4.5 4 1 1 5 5 5 1 Spt20 family Hydrolase PF00702.26 CDI79003.1 - 0.00084 19.7 0.0 0.00084 19.7 0.0 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Bap31 PF05529.12 CDI79003.1 - 0.013 15.4 0.4 0.013 15.4 0.4 2.9 3 0 0 3 3 3 0 Bap31/Bap29 transmembrane region DUF2232 PF09991.9 CDI79004.1 - 0.15 11.2 2.3 0.23 10.6 2.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) GEMIN8 PF15348.6 CDI79004.1 - 3.5 7.9 29.4 0.19 12.0 13.0 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DUF2052 PF09747.9 CDI79006.1 - 0.56 10.3 22.3 0.61 10.2 12.8 3.2 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) SelP_N PF04592.14 CDI79006.1 - 1.6 8.1 26.6 0.038 13.4 16.7 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF913 PF06025.12 CDI79006.1 - 4.1 6.3 12.9 2.4 7.0 3.5 3.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) SART-1 PF03343.13 CDI79007.1 - 0.0046 15.6 9.6 0.0057 15.3 9.6 1.2 1 0 0 1 1 1 1 SART-1 family Afi1 PF07792.12 CDI79007.1 - 0.0057 17.1 3.7 0.01 16.3 3.7 1.4 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking PAT1 PF09770.9 CDI79007.1 - 0.0066 14.8 11.4 0.0067 14.8 11.4 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI79007.1 - 0.0078 16.3 25.9 0.011 15.8 25.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 CDI79007.1 - 0.0079 15.7 4.7 0.012 15.1 4.7 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 CDI79007.1 - 0.011 15.5 3.6 0.019 14.8 3.6 1.3 1 0 0 1 1 1 0 Connexin MDM10 PF12519.8 CDI79007.1 - 0.012 14.5 1.5 0.017 14.0 1.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4366 PF14283.6 CDI79007.1 - 0.024 14.7 4.2 0.024 14.7 4.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) TRAP_alpha PF03896.16 CDI79007.1 - 0.044 13.0 0.5 0.56 9.4 0.4 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Band_3_cyto PF07565.13 CDI79007.1 - 0.048 13.5 5.1 0.084 12.7 5.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain ETRAMP PF09716.10 CDI79007.1 - 0.061 13.4 0.0 0.65 10.1 0.0 2.4 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SpoVR PF04293.13 CDI79007.1 - 0.061 12.0 3.4 0.077 11.7 3.4 1.2 1 0 0 1 1 1 0 SpoVR like protein SLC12 PF03522.15 CDI79007.1 - 0.074 12.1 5.8 0.086 11.9 5.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 eIF-3_zeta PF05091.12 CDI79007.1 - 0.13 11.3 13.5 0.16 10.9 13.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4808 PF16066.5 CDI79007.1 - 0.13 12.8 6.8 0.08 13.5 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4808) SID-1_RNA_chan PF13965.6 CDI79007.1 - 0.14 10.5 0.3 0.18 10.2 0.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 CDI79007.1 - 0.22 10.3 3.0 0.28 10.0 3.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CSG2 PF16965.5 CDI79007.1 - 0.24 10.3 2.6 0.36 9.7 2.6 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator FAM176 PF14851.6 CDI79007.1 - 0.28 10.9 8.2 5 6.8 7.8 2.2 2 0 0 2 2 2 0 FAM176 family DUF2828 PF11443.8 CDI79007.1 - 0.41 8.7 11.3 0.61 8.1 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Baculo_PP31 PF05311.11 CDI79007.1 - 0.41 10.1 6.6 0.6 9.6 6.6 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) MAPEG PF01124.18 CDI79007.1 - 0.49 10.3 10.5 1.5 8.7 1.0 2.8 3 1 0 3 3 3 0 MAPEG family PPL5 PF18168.1 CDI79007.1 - 0.62 9.3 5.7 1.1 8.5 5.7 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF2126 PF09899.9 CDI79007.1 - 0.71 7.9 5.6 0.99 7.4 5.6 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CDC45 PF02724.14 CDI79007.1 - 1.1 7.5 12.8 1.7 6.9 12.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4064 PF13273.6 CDI79007.1 - 1.2 9.4 3.0 2.7 8.3 0.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) Gti1_Pac2 PF09729.9 CDI79007.1 - 1.4 9.0 8.6 0.42 10.7 5.6 1.6 2 0 0 2 2 2 0 Gti1/Pac2 family GWT1 PF06423.12 CDI79007.1 - 2.1 8.5 3.2 21 5.2 3.2 2.4 2 1 0 2 2 2 0 GWT1 NST1 PF13945.6 CDI79007.1 - 2.1 8.4 20.9 3.7 7.6 20.9 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Eapp_C PF10238.9 CDI79007.1 - 2.3 8.3 14.0 5.8 7.0 14.0 1.6 1 0 0 1 1 1 0 E2F-associated phosphoprotein RabGAP-TBC PF00566.18 CDI79007.1 - 2.8 7.6 7.9 3.8 7.1 7.9 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain SARAF PF06682.12 CDI79007.1 - 3.7 7.1 13.5 8.5 5.9 13.3 1.6 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis NPR3 PF03666.13 CDI79007.1 - 4 6.1 11.2 6.2 5.5 11.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HbrB PF08539.11 CDI79007.1 - 6.3 6.8 5.7 15 5.6 5.7 1.5 1 0 0 1 1 1 0 HbrB-like Membralin PF09746.9 CDI79007.1 - 6.3 5.7 5.0 12 4.8 5.0 1.4 1 0 0 1 1 1 0 Tumour-associated protein Peptidase_S15 PF02129.18 CDI79007.1 - 9.3 5.8 12.3 0.59 9.7 7.1 1.6 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) AAA_23 PF13476.6 CDI79008.1 - 0.013 16.0 1.2 0.013 16.0 1.2 2.4 2 0 0 2 2 2 0 AAA domain SR-25 PF10500.9 CDI79008.1 - 0.015 14.9 7.6 0.015 14.9 7.6 3.9 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein Gaa1 PF04114.14 CDI79008.1 - 0.037 13.1 0.5 0.067 12.2 0.5 1.4 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component DUF2407 PF10302.9 CDI79008.1 - 0.31 11.6 0.0 0.31 11.6 0.0 3.7 3 0 0 3 3 3 0 DUF2407 ubiquitin-like domain RskA PF10099.9 CDI79008.1 - 5 7.4 61.1 0.15 12.3 23.3 4.9 1 1 4 5 5 5 0 Anti-sigma-K factor rskA RabGAP-TBC PF00566.18 CDI79010.1 - 1.6e-39 135.8 10.9 1.8e-39 135.6 5.8 3.1 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF3972 PF13118.6 CDI79010.1 - 0.17 12.3 0.7 0.37 11.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Use1 PF09753.9 CDI79010.1 - 6.9 6.3 8.8 22 4.6 8.8 1.9 1 0 0 1 1 1 0 Membrane fusion protein Use1 RskA PF10099.9 CDI79011.1 - 0.0011 19.4 18.0 0.0011 19.4 18.0 3.4 2 1 0 2 2 2 1 Anti-sigma-K factor rskA DUF2339 PF10101.9 CDI79011.1 - 0.0012 17.5 3.8 0.12 10.9 0.0 2.0 2 0 0 2 2 2 2 Predicted membrane protein (DUF2339) SUIM_assoc PF16619.5 CDI79011.1 - 0.006 16.6 3.7 0.006 16.6 3.7 7.1 5 2 0 5 5 5 3 Unstructured region C-term to UIM in Ataxin3 CcmF_C PF16327.5 CDI79011.1 - 0.064 12.5 8.9 0.021 14.1 3.3 2.1 2 0 0 2 2 2 0 Cytochrome c-type biogenesis protein CcmF C-terminal DUF726 PF05277.12 CDI79011.1 - 8.3 5.2 7.9 0.88 8.4 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF726) HSP90 PF00183.18 CDI79012.1 - 4e-05 22.7 0.0 4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Hsp90 protein DNMT1-RFD PF12047.8 CDI79013.1 - 3.3e-06 27.2 0.0 6.9e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain Auxin_resp PF06507.13 CDI79013.1 - 0.00028 21.1 0.0 0.00087 19.5 0.0 1.9 1 0 0 1 1 1 1 Auxin response factor RskA PF10099.9 CDI79013.1 - 0.0025 18.2 0.0 0.0025 18.2 0.0 29.3 7 6 13 20 20 20 2 Anti-sigma-K factor rskA HECT PF00632.25 CDI79014.1 - 1.6e-20 73.8 0.0 1.7e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RskA PF10099.9 CDI79015.1 - 4.7e-13 49.8 2.3 6.6e-08 33.1 2.8 10.4 4 3 4 8 8 8 2 Anti-sigma-K factor rskA GYF PF02213.16 CDI79015.1 - 9.4e-13 47.6 1.5 2.5e-12 46.3 1.5 1.7 1 0 0 1 1 1 1 GYF domain SUIM_assoc PF16619.5 CDI79015.1 - 0.0024 17.9 0.7 0.0024 17.9 0.7 18.8 8 6 3 11 11 11 1 Unstructured region C-term to UIM in Ataxin3 DUF979 PF06166.12 CDI79015.1 - 0.095 11.8 0.1 0.095 11.8 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF979) IQ PF00612.27 CDI79016.1 - 0.00013 21.5 21.0 0.004 16.8 0.5 4.3 3 0 0 3 3 3 3 IQ calmodulin-binding motif Zip PF02535.22 CDI79016.1 - 3.3 6.8 16.5 0.26 10.5 1.7 2.6 2 0 0 2 2 2 0 ZIP Zinc transporter Med15 PF09606.10 CDI79017.1 - 7.6 5.1 112.7 9.6 4.8 112.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Myosin_head PF00063.21 CDI79018.1 - 4.5e-21 74.8 10.4 9.9e-10 37.3 7.9 4.1 2 2 1 3 3 3 2 Myosin head (motor domain) DUF2722 PF10846.8 CDI79018.1 - 2.6e-06 26.6 13.9 6.7e-06 25.3 2.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI79018.1 - 0.0024 17.9 1.8 0.0024 17.9 1.8 3.4 2 1 0 2 2 1 1 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI79018.1 - 0.0027 16.5 2.4 0.038 12.8 0.6 2.1 2 0 0 2 2 2 1 Presenilin AIM3 PF17096.5 CDI79018.1 - 0.016 16.1 1.2 0.13 13.2 0.2 2.2 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 MecA PF05389.12 CDI79018.1 - 0.035 13.7 4.1 0.23 11.0 1.5 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) MH2 PF03166.14 CDI79018.1 - 0.055 13.7 0.5 0.055 13.7 0.5 2.1 2 0 0 2 2 2 0 MH2 domain DUF3371 PF11851.8 CDI79018.1 - 0.058 14.5 7.4 2.3 9.3 3.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) BRF1 PF07741.13 CDI79018.1 - 0.069 13.5 6.9 0.77 10.1 1.0 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DUF3464 PF11947.8 CDI79018.1 - 0.088 12.6 6.5 0.17 11.7 1.1 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 EPL1 PF10513.9 CDI79018.1 - 0.092 13.1 6.3 0.25 11.7 1.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like CPSF100_C PF13299.6 CDI79018.1 - 0.098 12.8 7.3 0.15 12.2 1.8 2.5 3 0 0 3 3 2 0 Cleavage and polyadenylation factor 2 C-terminal Slu7 PF11708.8 CDI79018.1 - 0.12 12.1 10.3 0.028 14.2 2.9 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor Mlh1_C PF16413.5 CDI79018.1 - 0.12 11.7 7.4 0.13 11.6 2.3 2.2 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus EOS1 PF12326.8 CDI79018.1 - 0.16 11.9 0.8 2.1 8.3 0.3 2.1 2 0 0 2 2 2 0 N-glycosylation protein Pex14_N PF04695.13 CDI79018.1 - 0.16 12.6 18.2 0.075 13.7 2.0 3.2 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2235 PF09994.9 CDI79018.1 - 0.2 11.0 2.8 0.15 11.3 0.4 1.8 2 0 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Suf PF05843.14 CDI79018.1 - 0.22 11.5 12.7 0.48 10.4 4.6 2.4 3 0 0 3 3 2 0 Suppressor of forked protein (Suf) CTU2 PF10288.9 CDI79018.1 - 0.25 11.6 7.0 2.3 8.5 2.6 2.4 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 SpoIIP PF07454.11 CDI79018.1 - 0.27 10.7 7.1 0.32 10.4 2.5 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) KRAP_IP3R_bind PF14722.6 CDI79018.1 - 0.28 10.9 9.5 0.23 11.2 2.9 2.2 2 0 0 2 2 2 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Eapp_C PF10238.9 CDI79018.1 - 0.3 11.2 7.9 0.4 10.7 2.2 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein Spt20 PF12090.8 CDI79018.1 - 0.33 10.6 34.6 0.67 9.5 4.7 2.4 2 0 0 2 2 2 0 Spt20 family DUF702 PF05142.12 CDI79018.1 - 0.39 11.2 8.0 0.62 10.5 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF4834 PF16118.5 CDI79018.1 - 0.46 11.5 13.4 2.7 9.0 6.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FmdE PF02663.14 CDI79018.1 - 0.47 10.5 1.9 4.7 7.3 0.4 2.7 3 0 0 3 3 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon MAT1 PF06391.13 CDI79018.1 - 0.68 9.7 15.8 0.88 9.4 8.5 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 CRF1 PF10380.9 CDI79018.1 - 0.96 9.8 3.6 2 8.8 0.5 2.3 2 0 0 2 2 2 0 Transcription factor CRF1 V_ATPase_I PF01496.19 CDI79018.1 - 1 7.2 5.4 1.1 7.0 1.6 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RAB3GAP2_N PF14655.6 CDI79018.1 - 1.1 8.4 11.2 2.9 7.1 1.4 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4820 PF16091.5 CDI79018.1 - 1.3 8.3 8.6 2.3 7.5 3.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Orf78 PF06024.12 CDI79018.1 - 1.5 9.2 5.9 1.2 9.4 0.7 2.4 2 0 0 2 2 2 0 Orf78 (ac78) DUF775 PF05603.12 CDI79018.1 - 1.5 8.3 11.6 3.1 7.3 4.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF775) RR_TM4-6 PF06459.12 CDI79018.1 - 1.6 8.5 8.5 14 5.4 5.6 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI79018.1 - 1.8 7.6 3.7 1.9 7.4 0.6 2.0 2 0 0 2 2 2 0 CLN3 protein Mit_KHE1 PF10173.9 CDI79018.1 - 1.8 8.6 5.6 2.9 7.9 2.2 2.2 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related WBP-1 PF11669.8 CDI79018.1 - 2.3 8.9 4.9 19 6.0 0.9 2.4 2 0 0 2 2 2 0 WW domain-binding protein 1 DNApol_Exo PF18136.1 CDI79018.1 - 2.4 7.2 6.9 0.6 9.2 1.9 2.0 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain DnaJ-X PF14308.6 CDI79018.1 - 2.4 7.5 10.7 0.75 9.2 4.4 2.2 2 0 0 2 2 2 0 X-domain of DnaJ-containing RPA43_OB PF17875.1 CDI79018.1 - 2.6 8.7 6.5 1.6 9.3 1.3 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Conotoxin PF02950.17 CDI79018.1 - 3.1 8.9 7.9 7.1 7.7 1.8 2.6 2 0 0 2 2 2 0 Conotoxin ORC_WH_C PF18137.1 CDI79018.1 - 3.4 7.7 10.5 14 5.8 6.2 2.4 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Connexin PF00029.19 CDI79018.1 - 3.7 7.2 8.5 3 7.5 4.9 2.1 2 0 0 2 2 2 0 Connexin Sec62 PF03839.16 CDI79018.1 - 3.8 6.9 6.5 1.9 8.0 1.4 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 EIIBC-GUT_N PF03612.14 CDI79018.1 - 4.2 7.1 10.8 4.8 6.9 4.6 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus RNA_pol_Rbc25 PF08292.12 CDI79018.1 - 5.7 7.2 7.9 3 8.1 1.8 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 FYDLN_acid PF09538.10 CDI79018.1 - 5.9 7.6 11.7 1.3 9.8 1.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) TMEM51 PF15345.6 CDI79018.1 - 6.8 6.5 14.5 21 4.8 8.1 2.5 2 0 0 2 2 2 0 Transmembrane protein 51 DUF1280 PF06918.14 CDI79019.1 - 0.24 11.0 0.1 0.39 10.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) IF-2B PF01008.17 CDI79022.1 - 6e-12 45.4 2.6 1.5e-11 44.1 2.6 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family DDHD PF02862.17 CDI79022.1 - 0.00047 20.4 5.3 0.00054 20.2 5.3 1.1 1 0 0 1 1 1 1 DDHD domain Macoilin PF09726.9 CDI79022.1 - 0.0015 17.2 11.4 0.0017 17.0 11.4 1.0 1 0 0 1 1 1 1 Macoilin family RskA PF10099.9 CDI79022.1 - 0.0017 18.6 8.4 0.0023 18.2 8.4 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA AF-4 PF05110.13 CDI79022.1 - 0.0027 15.9 18.5 0.0031 15.7 18.5 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI79022.1 - 0.0032 17.5 29.7 0.0036 17.4 29.7 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 CDI79022.1 - 0.0034 16.8 38.1 0.0046 16.4 38.1 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Neur_chan_memb PF02932.16 CDI79022.1 - 0.0045 17.1 7.4 0.0052 16.9 7.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 CDI79022.1 - 0.015 15.3 10.8 0.016 15.2 10.8 1.1 1 0 0 1 1 1 0 Velvet factor Suf PF05843.14 CDI79022.1 - 0.021 14.8 10.7 0.024 14.6 10.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) GREB1 PF15782.5 CDI79022.1 - 0.022 11.9 11.4 0.024 11.8 11.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF5523 PF17661.1 CDI79022.1 - 0.023 14.4 4.9 0.027 14.2 4.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF5427 PF10310.9 CDI79022.1 - 0.026 13.5 13.8 0.031 13.3 13.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Spore_coat_CotO PF14153.6 CDI79022.1 - 0.027 14.4 15.1 0.031 14.2 15.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO DUF719 PF05334.13 CDI79022.1 - 0.036 14.3 7.2 0.045 13.9 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Tim54 PF11711.8 CDI79022.1 - 0.056 12.2 5.7 0.067 12.0 5.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 MCU PF04678.13 CDI79022.1 - 0.057 13.5 5.6 0.069 13.2 5.6 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter PAT1 PF09770.9 CDI79022.1 - 0.095 11.0 23.7 0.11 10.8 23.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.13 CDI79022.1 - 0.096 13.3 21.3 0.15 12.7 21.3 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4045 PF13254.6 CDI79022.1 - 0.099 12.3 9.9 0.11 12.1 9.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) RR_TM4-6 PF06459.12 CDI79022.1 - 0.1 12.4 12.1 0.13 12.1 12.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI79022.1 - 0.14 10.6 1.2 0.16 10.4 1.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ctr PF04145.15 CDI79022.1 - 0.16 12.6 3.2 0.22 12.1 3.2 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Ndc1_Nup PF09531.10 CDI79022.1 - 0.16 10.6 5.8 0.18 10.5 5.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_S49_N PF08496.10 CDI79022.1 - 0.17 12.0 6.9 0.22 11.6 6.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal eIF-3_zeta PF05091.12 CDI79022.1 - 0.22 10.4 13.4 0.25 10.3 13.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 CDI79022.1 - 0.23 11.5 8.8 0.29 11.1 8.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Endostatin PF06482.11 CDI79022.1 - 0.24 10.8 13.9 0.27 10.7 13.9 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin EIF4E-T PF10477.9 CDI79022.1 - 0.31 9.8 18.9 0.34 9.7 18.9 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E SAPS PF04499.15 CDI79022.1 - 0.31 9.8 8.9 0.36 9.6 8.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BAF1_ABF1 PF04684.13 CDI79022.1 - 0.32 10.0 17.5 0.4 9.7 17.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor VIR_N PF15912.5 CDI79022.1 - 0.39 10.3 7.5 0.58 9.7 7.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Presenilin PF01080.17 CDI79022.1 - 0.44 9.2 19.2 0.57 8.9 19.2 1.1 1 0 0 1 1 1 0 Presenilin NEMP PF10225.9 CDI79022.1 - 0.57 9.8 1.4 0.74 9.4 1.4 1.1 1 0 0 1 1 1 0 NEMP family Paf1 PF03985.13 CDI79022.1 - 0.73 8.8 13.2 0.91 8.4 13.2 1.0 1 0 0 1 1 1 0 Paf1 DUF4050 PF13259.6 CDI79022.1 - 0.74 10.1 10.5 1 9.6 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) SLC12 PF03522.15 CDI79022.1 - 0.83 8.6 12.3 0.95 8.4 12.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 GET2 PF08690.10 CDI79022.1 - 0.83 9.3 11.6 0.96 9.1 11.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Spem1 PF15670.5 CDI79022.1 - 0.92 9.0 15.2 1.1 8.8 15.2 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 Hydin_ADK PF17213.3 CDI79022.1 - 0.93 9.7 13.4 1.3 9.2 13.4 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF1387 PF07139.11 CDI79022.1 - 0.96 9.1 13.1 1.1 8.9 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Folate_carrier PF01770.18 CDI79022.1 - 1.1 8.0 6.4 1.3 7.7 6.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Serinc PF03348.15 CDI79022.1 - 1.1 8.1 6.1 1.3 7.9 6.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MMR1 PF08505.10 CDI79022.1 - 1.2 9.3 17.8 1.6 9.0 17.8 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CDK5_activator PF03261.15 CDI79022.1 - 1.4 8.4 10.8 1.6 8.2 10.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein FAM199X PF15814.5 CDI79022.1 - 1.5 7.8 5.8 1.8 7.5 5.8 1.1 1 0 0 1 1 1 0 Protein family FAM199X OATP PF03137.20 CDI79022.1 - 1.5 7.0 3.8 1.7 6.9 3.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family R_equi_Vir PF05526.11 CDI79022.1 - 1.8 8.4 9.1 2.8 7.8 9.1 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein TMEM174 PF15029.6 CDI79022.1 - 1.9 8.2 7.6 2.5 7.8 7.6 1.3 1 0 0 1 1 1 0 Transmembrane protein 174 NicO PF03824.16 CDI79022.1 - 2.1 7.6 12.8 2.9 7.2 12.8 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein CLN3 PF02487.17 CDI79022.1 - 2.1 7.3 8.1 2.5 7.0 8.1 1.2 1 0 0 1 1 1 0 CLN3 protein TCP PF03634.13 CDI79022.1 - 2.3 8.8 17.3 3.1 8.4 17.3 1.1 1 0 0 1 1 1 0 TCP family transcription factor Vac7 PF12751.7 CDI79022.1 - 2.5 7.4 14.7 3.1 7.1 14.7 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 MDM10 PF12519.8 CDI79022.1 - 3.5 6.4 10.7 4.2 6.1 10.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Zip PF02535.22 CDI79022.1 - 3.8 6.6 19.7 4.7 6.3 19.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter BORG_CEP PF14957.6 CDI79022.1 - 3.8 8.7 9.6 5.2 8.2 9.6 1.2 1 0 0 1 1 1 0 Cdc42 effector DUF4407 PF14362.6 CDI79022.1 - 4.1 6.7 13.3 5.3 6.3 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 CDI79022.1 - 4.2 5.4 12.8 4.7 5.2 12.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gti1_Pac2 PF09729.9 CDI79022.1 - 4.5 7.3 13.7 6 6.9 13.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF5385 PF17359.2 CDI79022.1 - 4.5 6.8 10.7 6.1 6.3 10.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) API5 PF05918.11 CDI79022.1 - 5.2 5.8 12.2 6.8 5.4 12.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Membralin PF09746.9 CDI79022.1 - 5.6 5.9 7.3 6.7 5.6 7.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Connexin PF00029.19 CDI79022.1 - 5.7 6.6 13.2 7.5 6.2 13.2 1.2 1 0 0 1 1 1 0 Connexin Band_3_cyto PF07565.13 CDI79022.1 - 6.7 6.4 15.8 8.3 6.1 15.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FAM176 PF14851.6 CDI79022.1 - 6.9 6.3 7.6 9.3 5.9 7.6 1.2 1 0 0 1 1 1 0 FAM176 family LMBR1 PF04791.16 CDI79022.1 - 7.3 5.4 5.6 8 5.2 5.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 CDI79023.1 - 4.3e-06 27.3 0.8 0.013 16.3 0.4 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat Ribosomal_60s PF00428.19 CDI79023.1 - 0.00071 20.1 8.0 0.00071 20.1 8.0 10.3 7 5 3 10 10 10 3 60s Acidic ribosomal protein FTZ PF03867.14 CDI79023.1 - 0.01 15.4 2.1 0.01 15.4 2.1 6.5 7 1 1 8 8 8 0 Fushi tarazu (FTZ), N-terminal region ANAPC4_WD40 PF12894.7 CDI79023.1 - 0.033 14.5 0.4 28 5.1 0.0 4.1 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PH_6 PF15406.6 CDI79023.1 - 2.2 8.6 0.0 2.2 8.6 0.0 4.0 4 1 1 5 5 5 0 Pleckstrin homology domain Activator_LAG-3 PF11498.8 CDI79024.1 - 3.3 6.6 131.2 0.24 10.3 23.7 3.2 3 0 0 3 3 3 0 Transcriptional activator LAG-3 DUF2555 PF10742.9 CDI79025.1 - 0.52 10.2 2.9 2.6 7.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2555) Sina PF03145.16 CDI79026.1 - 1.9e-19 70.4 4.3 4.5e-13 49.6 3.7 2.8 3 0 0 3 3 3 2 Seven in absentia protein family SR-25 PF10500.9 CDI79026.1 - 3.5e-05 23.5 8.9 3.5e-05 23.5 8.9 3.1 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 CDI79026.1 - 0.0038 18.0 7.8 0.0038 18.0 7.8 5.8 4 1 1 5 5 5 1 Chorion family 2 IMUP PF15761.5 CDI79026.1 - 0.014 16.1 9.1 0.014 16.1 9.1 4.0 4 1 1 5 5 5 0 Immortalisation up-regulated protein zf-TRAF PF02176.18 CDI79026.1 - 0.062 14.0 0.9 0.062 14.0 0.9 3.3 1 1 1 2 2 2 0 TRAF-type zinc finger Ribosomal_60s PF00428.19 CDI79026.1 - 0.1 13.2 0.1 0.1 13.2 0.1 6.0 4 1 0 4 4 4 0 60s Acidic ribosomal protein Macoilin PF09726.9 CDI79026.1 - 4.4 5.8 6.2 1.9 7.0 0.8 2.3 2 0 0 2 2 2 0 Macoilin family Spt20 PF12090.8 CDI79026.1 - 5.9 6.4 10.2 12 5.4 10.2 1.4 1 0 0 1 1 1 0 Spt20 family FixQ PF05545.11 CDI79028.1 - 0.6 10.1 2.8 1 9.4 0.1 2.4 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ GP67 PF17634.2 CDI79029.1 - 0.00014 22.2 14.2 0.00016 22.0 14.2 1.1 1 0 0 1 1 1 1 Gene product 67 DNA_pol_phi PF04931.13 CDI79029.1 - 0.0062 14.7 11.0 0.0062 14.7 11.0 1.1 1 0 0 1 1 1 1 DNA polymerase phi FAM176 PF14851.6 CDI79029.1 - 0.036 13.7 3.6 0.044 13.4 3.6 1.3 1 0 0 1 1 1 0 FAM176 family PPP4R2 PF09184.11 CDI79029.1 - 0.043 13.4 8.0 0.043 13.4 8.0 1.1 1 0 0 1 1 1 0 PPP4R2 DUF2722 PF10846.8 CDI79029.1 - 0.051 12.5 6.0 0.051 12.5 6.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) NOA36 PF06524.12 CDI79029.1 - 0.06 12.7 15.4 0.062 12.6 15.4 1.0 1 0 0 1 1 1 0 NOA36 protein TFB6 PF17110.5 CDI79029.1 - 0.071 12.9 3.2 0.07 12.9 3.2 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RXT2_N PF08595.11 CDI79029.1 - 0.072 13.1 5.9 0.079 13.0 5.9 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF1840 PF08895.11 CDI79029.1 - 0.11 12.8 0.4 0.12 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Sporozoite_P67 PF05642.11 CDI79029.1 - 0.12 10.5 5.6 0.11 10.5 5.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Rhabdo_ncap PF00945.18 CDI79029.1 - 0.28 10.0 4.8 0.27 10.1 4.8 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DUF2457 PF10446.9 CDI79029.1 - 0.55 9.3 18.9 0.54 9.4 18.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRN3 PF05327.11 CDI79029.1 - 0.69 8.4 8.2 0.64 8.5 8.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Astro_capsid_p PF12226.8 CDI79029.1 - 0.69 9.0 7.0 0.71 9.0 7.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 CDI79029.1 - 1.2 7.2 11.7 1.2 7.3 11.7 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CDI79029.1 - 1.3 7.2 10.4 1.2 7.4 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Dicty_REP PF05086.12 CDI79029.1 - 4.7 5.0 12.0 4.9 5.0 12.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Patched PF02460.18 CDI79030.1 - 2.2e-42 145.2 0.0 4.1e-37 127.7 0.1 2.2 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 CDI79030.1 - 1.6e-25 89.7 1.7 4.6e-25 88.3 1.7 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation SUIM_assoc PF16619.5 CDI79030.1 - 0.0023 18.0 6.0 0.0023 18.0 6.0 5.8 4 2 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 XRN_N PF03159.18 CDI79032.1 - 5.5e-50 170.0 0.4 9.6e-46 156.2 0.0 4.1 3 2 1 4 4 4 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDI79032.1 - 1.1e-42 146.5 2.3 9.9e-26 90.7 2.7 5.0 5 0 0 5 5 5 3 Xrn1 helical domain DUF2040 PF09745.9 CDI79033.1 - 9.8e-18 64.4 16.0 5.6e-16 58.7 5.2 4.1 4 0 0 4 4 4 2 Coiled-coil domain-containing protein 55 (DUF2040) RskA PF10099.9 CDI79033.1 - 0.0024 18.2 20.2 0.0024 18.2 20.2 3.2 3 1 0 3 3 3 2 Anti-sigma-K factor rskA RAB3GAP2_N PF14655.6 CDI79033.1 - 0.18 11.0 3.9 0.36 10.0 3.9 1.6 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF572 PF04502.13 CDI79033.1 - 1.3 8.6 25.1 1.8 8.1 16.5 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) TMEM208_SND2 PF05620.11 CDI79034.1 - 0.11 12.3 2.8 0.15 11.9 2.0 1.6 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 PTS_EIIC PF02378.18 CDI79034.1 - 0.75 8.8 4.3 9.2 5.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase system, EIIC FSA_C PF10479.9 CDI79034.1 - 1.2 7.2 4.2 1.7 6.7 4.2 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF4179 PF13786.6 CDI79034.1 - 7.7 7.1 10.5 27 5.3 3.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) tRNA-synt_1c PF00749.21 CDI79035.1 - 6.2e-82 275.0 0.4 2.9e-50 171.0 0.0 4.0 3 1 1 4 4 4 2 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CDI79035.1 - 5.2e-54 182.7 0.0 5.6e-49 166.4 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), anti-codon binding domain RNA_capsid PF03035.14 CDI79035.1 - 0.0078 16.2 6.5 1 9.3 0.6 2.6 2 0 0 2 2 2 2 Calicivirus putative RNA polymerase/capsid protein TAF1_subA PF14929.6 CDI79035.1 - 0.019 14.4 0.0 5.6 6.3 0.0 2.3 2 0 0 2 2 2 0 TAF RNA Polymerase I subunit A G0-G1_switch_2 PF15103.6 CDI79035.1 - 0.039 14.4 11.2 0.53 10.7 1.7 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 Eapp_C PF10238.9 CDI79035.1 - 0.29 11.2 11.5 1.5 8.9 1.9 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein GOLD_2 PF13897.6 CDI79035.1 - 5.9 7.4 6.5 1.9 9.0 0.3 2.5 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking DHH PF01368.20 CDI79036.1 - 0.22 11.8 0.0 0.22 11.8 0.0 2.4 2 1 1 3 3 3 0 DHH family TFIIA PF03153.13 CDI79036.1 - 0.43 10.5 8.8 0.57 10.1 8.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TBCA PF02970.16 CDI79037.1 - 6.3e-15 55.3 4.7 6.3e-15 55.3 4.7 2.6 2 1 1 3 3 3 1 Tubulin binding cofactor A DUF2722 PF10846.8 CDI79037.1 - 0.0063 15.5 6.5 0.0079 15.2 6.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) FSH1 PF03959.13 CDI79037.1 - 0.014 15.1 0.7 0.018 14.7 0.7 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PHC2_SAM_assoc PF16616.5 CDI79037.1 - 0.017 15.9 1.6 0.031 15.1 1.6 1.5 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 TFIIA PF03153.13 CDI79037.1 - 0.036 14.1 16.1 0.045 13.7 16.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI79037.1 - 0.083 13.0 4.0 0.1 12.7 4.0 1.2 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpb1_1 PF04997.12 CDI79037.1 - 0.084 12.2 0.3 0.084 12.2 0.3 2.0 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 1 CPSF100_C PF13299.6 CDI79037.1 - 0.15 12.2 6.5 0.27 11.4 6.5 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2052 PF09747.9 CDI79037.1 - 0.17 12.0 15.1 0.26 11.4 15.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 CDI79037.1 - 0.28 9.9 9.1 0.34 9.6 9.1 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI79037.1 - 0.51 10.4 5.4 0.59 10.2 5.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UBA PF00627.31 CDI79038.1 - 2.4e-22 78.4 9.2 8.6e-12 44.7 1.1 2.8 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 CDI79038.1 - 2.8e-22 78.2 8.3 2.8e-22 78.2 8.3 2.2 2 0 0 2 2 1 1 XPC-binding domain ubiquitin PF00240.23 CDI79038.1 - 1.9e-05 24.3 0.1 1.9e-05 24.3 0.1 1.6 2 0 0 2 2 1 1 Ubiquitin family DUF2722 PF10846.8 CDI79038.1 - 0.0018 17.3 4.0 0.0027 16.7 4.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Rad60-SLD_2 PF13881.6 CDI79038.1 - 0.1 12.7 0.0 0.1 12.7 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like WIYLD PF10440.9 CDI79038.1 - 0.12 12.2 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain Suf PF05843.14 CDI79038.1 - 0.19 11.7 8.7 0.043 13.8 5.5 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Dehydrin PF00257.19 CDI79038.1 - 0.26 11.8 13.2 0.89 10.1 5.5 2.3 2 0 0 2 2 2 0 Dehydrin DUF2407 PF10302.9 CDI79038.1 - 0.36 11.4 5.0 1.3 9.6 5.0 2.0 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Hamartin PF04388.12 CDI79038.1 - 1.4 7.5 6.7 0.98 8.0 5.1 1.5 2 0 0 2 2 2 0 Hamartin protein FAM196 PF15265.6 CDI79038.1 - 2.7 7.4 11.9 4.3 6.7 11.9 1.2 1 0 0 1 1 1 0 FAM196 family Presenilin PF01080.17 CDI79038.1 - 6.6 5.4 5.4 9.6 4.9 5.4 1.2 1 0 0 1 1 1 0 Presenilin PG_binding_3 PF09374.10 CDI79039.1 - 0.086 13.1 0.2 0.22 11.8 0.2 1.7 1 0 0 1 1 1 0 Predicted Peptidoglycan domain TERB2 PF15101.6 CDI79040.1 - 0.0013 18.8 1.0 0.0013 18.8 1.0 2.0 2 0 0 2 2 2 1 Telomere-associated protein TERB2 CDT1 PF08839.11 CDI79040.1 - 0.004 17.5 0.7 0.0069 16.7 0.7 1.4 1 0 0 1 1 1 1 DNA replication factor CDT1 like Spore_coat_CotO PF14153.6 CDI79040.1 - 0.021 14.8 2.1 0.021 14.8 2.1 3.2 3 1 0 3 3 1 0 Spore coat protein CotO TPR_8 PF13181.6 CDI79040.1 - 0.03 14.5 0.1 0.18 12.1 0.0 2.5 2 0 0 2 2 1 0 Tetratricopeptide repeat V_ATPase_I PF01496.19 CDI79040.1 - 0.065 11.2 1.9 0.1 10.5 1.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rxt3 PF08642.10 CDI79040.1 - 0.11 13.2 0.9 0.67 10.7 0.2 2.4 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Suf PF05843.14 CDI79040.1 - 0.27 11.2 16.8 0.073 13.0 6.6 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4199 PF13858.6 CDI79040.1 - 0.28 11.6 1.0 0.8 10.1 1.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) OATP PF03137.20 CDI79040.1 - 0.36 9.1 1.6 0.6 8.3 1.6 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Glucan_synthase PF02364.15 CDI79040.1 - 0.51 8.4 3.8 0.71 8.0 3.8 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase component FAM60A PF15396.6 CDI79040.1 - 0.53 10.2 5.2 14 5.6 4.3 2.2 2 0 0 2 2 2 0 Protein Family FAM60A MecA PF05389.12 CDI79040.1 - 0.64 9.6 7.7 0.048 13.3 2.3 1.8 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) EOS1 PF12326.8 CDI79040.1 - 0.76 9.7 2.9 4.4 7.2 3.9 1.7 1 1 0 1 1 1 0 N-glycosylation protein Spt20 PF12090.8 CDI79040.1 - 1.1 8.9 34.1 0.24 11.0 27.9 2.4 3 0 0 3 3 3 0 Spt20 family Tim54 PF11711.8 CDI79040.1 - 2.6 6.7 7.9 0.19 10.5 0.5 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Eapp_C PF10238.9 CDI79040.1 - 3.2 7.8 11.1 2 8.5 5.5 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF702 PF05142.12 CDI79040.1 - 4.6 7.7 9.6 2 8.9 3.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF1764 PF08576.10 CDI79040.1 - 4.8 8.1 11.3 0.38 11.7 3.9 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) EPL1 PF10513.9 CDI79040.1 - 5.7 7.3 13.8 7.2 7.0 9.9 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Ham1p_like PF01725.16 CDI79041.1 - 8.1e-19 68.3 0.0 1.3e-08 35.0 0.1 2.1 1 1 1 2 2 2 2 Ham1 family TRAPPC9-Trs120 PF08626.11 CDI79041.1 - 0.17 9.2 0.1 0.18 9.1 0.1 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit SR-25 PF10500.9 CDI79041.1 - 0.36 10.4 7.2 0.61 9.7 6.7 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 CDI79042.1 - 0.00023 19.9 6.8 0.00023 19.9 6.8 2.6 3 0 0 3 3 3 1 Macoilin family UPF0524 PF15823.5 CDI79042.1 - 0.076 12.4 0.1 0.076 12.4 0.1 3.0 3 0 0 3 3 3 0 UPF0524 of C3orf70 Dicty_REP PF05086.12 CDI79042.1 - 0.44 8.5 10.1 0.64 7.9 10.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Ribosomal_L7Ae PF01248.26 CDI79044.1 - 7.7e-25 86.5 0.3 9.9e-25 86.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CDI79044.1 - 0.014 15.3 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 CDI79044.1 - 0.091 12.8 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 TGT PF01702.18 CDI79045.1 - 8.5e-10 38.3 0.0 2.9e-09 36.6 0.0 2.0 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase WD40 PF00400.32 CDI79046.1 - 0.16 12.9 4.2 2.2 9.3 0.2 4.3 3 0 0 3 3 3 0 WD domain, G-beta repeat AP2 PF00847.20 CDI79047.1 - 1.5e-10 41.2 0.0 1.7e-09 37.8 0.0 3.0 1 0 0 1 1 1 1 AP2 domain DUF2920 PF11144.8 CDI79048.1 - 0.44 9.7 7.5 1.1 8.4 7.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) DUF2973 PF11189.8 CDI79048.1 - 4.9 7.3 19.5 0.9 9.7 3.4 4.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2973) Citrate_synt PF00285.21 CDI79049.1 - 1.4e-90 304.0 0.0 1.4e-90 304.0 0.0 2.2 2 1 0 2 2 2 1 Citrate synthase, C-terminal domain SR-25 PF10500.9 CDI79049.1 - 0.35 10.4 3.5 0.54 9.8 3.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TAF4 PF05236.14 CDI79049.1 - 0.63 9.7 3.8 0.98 9.1 3.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Rrn6 PF10214.9 CDI79049.1 - 3 6.2 4.3 4.2 5.7 4.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF515 PF04415.12 CDI79049.1 - 3.8 5.8 4.2 5.8 5.2 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DCX PF03607.17 CDI79050.1 - 5.9e-09 35.9 0.0 9e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Doublecortin RNase_Zc3h12a PF11977.8 CDI79051.1 - 1.8e-08 34.3 0.0 1.8e-08 34.3 0.0 2.9 3 0 0 3 3 3 1 Zc3h12a-like Ribonuclease NYN domain CopC PF04234.12 CDI79051.1 - 0.077 14.0 2.3 1.1 10.4 2.3 3.2 1 0 0 1 1 1 0 CopC domain Methyltr_RsmB-F PF01189.17 CDI79052.1 - 2.4e-39 135.1 0.1 4.8e-22 78.6 0.0 3.4 3 1 1 4 4 4 2 16S rRNA methyltransferase RsmB/F Hydrophob_seed PF14547.6 CDI79052.1 - 0.15 12.3 0.8 0.28 11.4 0.8 1.4 1 0 0 1 1 1 0 Hydrophobic seed protein Pkinase PF00069.25 CDI79054.1 - 3.3e-09 36.5 0.0 3.3e-09 36.5 0.0 4.5 3 1 0 3 3 3 2 Protein kinase domain BAF1_ABF1 PF04684.13 CDI79054.1 - 0.032 13.3 0.1 0.032 13.3 0.1 4.0 3 1 1 4 4 4 0 BAF1 / ABF1 chromatin reorganising factor FXa_inhibition PF14670.6 CDI79055.1 - 2.6e-32 110.8 58.6 9e-11 41.9 4.0 6.3 5 1 1 6 6 6 5 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDI79055.1 - 1.5e-31 107.9 50.5 3.7e-08 33.2 0.1 8.2 8 0 0 8 8 8 6 Complement Clr-like EGF-like EGF_CA PF07645.15 CDI79055.1 - 1.1e-21 76.8 70.4 4.2e-10 39.7 1.7 8.0 9 0 0 9 9 9 5 Calcium-binding EGF domain EGF PF00008.27 CDI79055.1 - 1.5e-14 54.0 52.5 0.00051 20.3 3.3 6.7 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.7 CDI79055.1 - 2.3e-11 43.9 44.0 0.0016 19.0 1.8 6.4 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_3 PF12947.7 CDI79055.1 - 6.4e-11 42.3 51.2 0.0017 18.5 0.2 6.9 6 0 0 6 6 6 4 EGF domain Plasmod_Pvs28 PF06247.11 CDI79055.1 - 0.0069 16.7 2.9 0.0069 16.7 2.9 6.4 6 2 1 7 7 7 3 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 CDI79055.1 - 0.0079 16.2 39.3 0.029 14.4 2.1 7.1 7 0 0 7 7 7 3 MSP1 EGF domain 1 RskA PF10099.9 CDI79055.1 - 0.15 12.3 0.0 0.15 12.3 0.0 8.1 2 2 3 5 5 5 0 Anti-sigma-K factor rskA DHC_N1 PF08385.12 CDI79056.1 - 2.9e-109 366.3 15.3 2.7e-59 201.3 6.5 3.1 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 1 Virul_Fac PF10139.9 CDI79056.1 - 0.013 13.7 6.9 0.023 13.0 5.3 2.1 2 0 0 2 2 2 0 Putative bacterial virulence factor HbrB PF08539.11 CDI79056.1 - 0.021 14.8 1.7 0.58 10.1 0.0 2.9 3 0 0 3 3 3 0 HbrB-like DUF4942 PF13708.6 CDI79056.1 - 0.07 13.1 0.1 0.57 10.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4942) SR-25 PF10500.9 CDI79056.1 - 0.14 11.7 14.8 1.1 8.8 5.4 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Syntaxin-18_N PF10496.9 CDI79056.1 - 0.77 10.1 5.4 21 5.5 0.2 4.5 4 0 0 4 4 4 0 SNARE-complex protein Syntaxin-18 N-terminus DUF4692 PF15763.5 CDI79056.1 - 1.9 8.9 8.0 4.3 7.8 1.2 2.9 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Med3 PF11593.8 CDI79056.1 - 2.2 7.4 37.4 0.62 9.2 30.6 3.1 3 1 1 4 4 4 0 Mediator complex subunit 3 fungal MID_MedPIWI PF18296.1 CDI79056.1 - 2.8 7.7 8.1 5 6.8 0.3 3.2 3 0 0 3 3 3 0 MID domain of medPIWI AAA_6 PF12774.7 CDI79057.1 - 2.2e-147 490.3 0.0 3.6e-147 489.6 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI79057.1 - 4.5e-79 266.4 7.2 8.2e-46 156.9 8.4 2.4 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 2 AAA_5 PF07728.14 CDI79057.1 - 5.5e-19 68.5 0.0 3.6e-10 40.0 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI79057.1 - 3.8e-05 24.3 0.3 0.088 13.3 0.0 3.5 4 0 0 4 4 4 2 AAA domain AAA_22 PF13401.6 CDI79057.1 - 0.0015 18.8 0.1 18 5.6 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA PF00004.29 CDI79057.1 - 0.0029 18.1 0.2 0.065 13.6 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CDI79057.1 - 0.0032 17.4 0.1 0.15 12.0 0.1 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 CDI79057.1 - 0.0064 16.2 0.2 3.2 7.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDI79057.1 - 0.0089 16.4 1.3 4.6 7.6 0.0 3.4 4 0 0 4 4 4 1 AAA ATPase domain RNA_helicase PF00910.22 CDI79057.1 - 0.021 15.2 0.1 13 6.2 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_7 PF12775.7 CDI79057.1 - 0.022 14.3 0.0 4 6.9 0.0 3.1 3 0 0 3 3 3 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 CDI79057.1 - 0.093 12.1 0.3 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Dynein_AAA_lid PF17852.1 CDI79058.1 - 6.2e-25 87.8 1.5 1.1e-24 86.9 1.5 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_7 PF12775.7 CDI79058.1 - 1.2e-09 37.9 0.1 4.4e-09 36.1 0.1 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 CDI79058.1 - 0.0007 20.1 0.1 0.0016 19.0 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CDI79058.1 - 0.0028 17.3 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 CDI79058.1 - 0.019 14.1 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) G-alpha PF00503.20 CDI79058.1 - 0.025 13.8 0.1 0.045 12.9 0.1 1.4 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 CDI79058.1 - 0.046 13.6 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 CDI79058.1 - 0.052 12.8 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 CDI79058.1 - 0.079 13.3 0.1 0.19 12.1 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CDI79058.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 CDI79058.1 - 0.19 11.6 0.2 0.42 10.4 0.2 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 CDI79058.1 - 0.28 11.7 0.4 0.65 10.5 0.4 1.6 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 CDI79063.1 - 0.0084 16.1 44.8 0.09 12.8 24.1 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Med19 PF10278.9 CDI79063.1 - 0.015 15.3 4.8 0.015 15.3 4.8 1.7 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 EPL1 PF10513.9 CDI79063.1 - 0.062 13.7 14.1 2.5 8.5 0.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like DDHD PF02862.17 CDI79063.1 - 0.071 13.3 7.9 3.4 7.8 4.3 2.3 2 0 0 2 2 2 0 DDHD domain EBP50_C PF09007.11 CDI79063.1 - 0.21 12.6 18.2 1.5 9.9 1.3 2.5 2 0 0 2 2 2 0 EBP50, C-terminal BORG_CEP PF14957.6 CDI79063.1 - 0.52 11.5 17.1 1.8 9.7 1.8 2.3 2 0 0 2 2 2 0 Cdc42 effector FAM60A PF15396.6 CDI79063.1 - 0.93 9.5 9.2 4.3 7.3 0.0 2.1 2 0 0 2 2 2 0 Protein Family FAM60A SPX PF03105.19 CDI79063.1 - 1.1 9.1 20.8 0.14 12.0 2.2 2.1 2 0 0 2 2 2 0 SPX domain Activator_LAG-3 PF11498.8 CDI79063.1 - 1.4 7.8 46.5 0.15 11.0 22.0 2.4 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI79063.1 - 1.7 8.2 49.1 1 8.9 13.3 2.3 2 0 0 2 2 2 0 Spt20 family Ecl1 PF12855.7 CDI79063.1 - 2.4 9.3 24.7 1.8 9.7 6.8 2.1 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins SR-25 PF10500.9 CDI79063.1 - 5.2 6.6 28.9 2.6 7.6 16.5 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1645 PF07816.11 CDI79063.1 - 5.8 7.5 19.5 2.3 8.8 8.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) CPSF100_C PF13299.6 CDI79063.1 - 6.1 7.0 14.0 13 5.9 7.6 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM199X PF15814.5 CDI79063.1 - 8.5 5.3 23.9 3.4 6.7 6.1 2.2 2 0 0 2 2 2 0 Protein family FAM199X Lin-8 PF03353.15 CDI79063.1 - 9.7 5.6 30.6 8.4 5.8 14.9 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SMC_N PF02463.19 CDI79064.1 - 0.0083 15.6 0.0 0.0083 15.6 0.0 2.4 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain UCH PF00443.29 CDI79064.1 - 0.027 14.0 0.0 0.027 14.0 0.0 2.7 2 1 1 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase DUF3458_C PF17432.2 CDI79065.1 - 6.3e-72 242.7 3.9 6.9e-72 242.5 3.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats ERAP1_C PF11838.8 CDI79065.1 - 0.026 14.1 0.3 0.11 12.0 0.1 1.8 1 1 0 1 1 1 0 ERAP1-like C-terminal domain Raf1_N PF18578.1 CDI79065.1 - 0.61 10.6 4.1 0.61 10.6 0.3 2.4 3 0 0 3 3 3 0 Rubisco accumulation factor 1 alpha helical domain Pkinase PF00069.25 CDI79066.1 - 5.5e-18 65.3 0.0 2.2e-07 30.5 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain EF-hand_1 PF00036.32 CDI79066.1 - 1.9e-08 33.3 0.0 0.011 15.3 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 CDI79066.1 - 2.6e-07 31.0 0.0 0.057 13.9 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI79066.1 - 6.5e-06 25.7 0.3 0.14 12.2 0.2 3.5 3 0 0 3 3 3 2 EF-hand domain Pkinase_Tyr PF07714.17 CDI79066.1 - 3.5e-05 23.2 0.5 0.37 10.0 0.2 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase EF-hand_5 PF13202.6 CDI79066.1 - 4.2e-05 22.8 0.1 0.2 11.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI79066.1 - 0.00033 20.4 0.1 0.095 12.6 0.1 3.4 3 0 0 3 3 3 1 EF-hand domain pair SOSSC PF15925.5 CDI79066.1 - 0.53 11.6 8.2 32 5.9 0.1 4.0 4 0 0 4 4 4 0 SOSS complex subunit C AAA PF00004.29 CDI79068.1 - 1.1e-77 258.9 0.0 4.8e-44 150.0 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI79068.1 - 1.5e-23 82.3 13.5 1.4e-13 50.4 0.6 3.4 3 1 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 CDI79068.1 - 2.3e-21 75.7 0.8 5.5e-21 74.5 0.8 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 CDI79068.1 - 6.8e-09 36.1 0.0 0.00049 20.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDI79068.1 - 3.1e-07 30.9 0.4 0.002 18.5 0.0 4.1 3 1 1 4 4 4 1 AAA ATPase domain Vps4_C PF09336.10 CDI79068.1 - 1e-06 28.6 0.1 0.00056 19.9 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 CDI79068.1 - 4.3e-06 26.6 0.1 0.00021 21.0 0.0 3.4 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain CDC48_2 PF02933.17 CDI79068.1 - 4.5e-05 23.2 0.0 0.00014 21.5 0.0 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 CDI79068.1 - 0.00013 22.3 0.0 0.16 12.2 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_25 PF13481.6 CDI79068.1 - 0.00019 21.1 0.1 0.87 9.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 CDI79068.1 - 0.00063 19.8 0.0 0.35 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CDI79068.1 - 0.0028 17.7 3.9 0.11 12.5 0.0 3.4 3 2 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDI79068.1 - 0.0056 16.9 0.0 0.019 15.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CDI79068.1 - 0.0078 15.6 0.0 2.7 7.3 0.0 2.3 2 0 0 2 2 2 1 KaiC RNA_helicase PF00910.22 CDI79068.1 - 0.008 16.5 0.0 0.021 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Viral_helicase1 PF01443.18 CDI79068.1 - 0.0096 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 CDI79068.1 - 0.015 14.7 0.1 0.04 13.3 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CDI79068.1 - 0.026 13.7 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 CDI79068.1 - 0.032 14.8 0.0 0.081 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDI79068.1 - 0.036 14.0 0.0 0.57 10.1 0.0 2.4 1 1 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 CDI79068.1 - 0.058 13.3 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDI79068.1 - 0.08 12.7 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 CDI79068.1 - 0.086 13.4 0.0 0.31 11.5 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CDI79068.1 - 0.14 11.6 0.0 0.38 10.2 0.0 1.6 2 0 0 2 2 1 0 P-loop containing dynein motor region UCH PF00443.29 CDI79069.1 - 2e-39 135.7 0.0 8e-35 120.6 0.0 4.1 4 2 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase ABC_tran PF00005.27 CDI79071.1 - 1.7e-45 154.9 1.0 4.7e-22 79.0 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 CDI79071.1 - 3.7e-18 65.3 0.7 3.7e-18 65.3 0.7 4.1 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.6 CDI79071.1 - 5.3e-18 65.9 10.2 2.2e-06 27.7 0.2 4.5 4 1 1 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDI79071.1 - 4.8e-10 39.3 5.0 0.00034 20.1 0.0 4.9 3 2 1 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDI79071.1 - 5.3e-07 29.3 0.8 0.017 14.8 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI79071.1 - 1.4e-06 28.3 0.4 0.037 13.9 0.2 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_33 PF13671.6 CDI79071.1 - 1.2e-05 25.5 0.1 0.065 13.4 0.0 3.2 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 CDI79071.1 - 2e-05 24.7 0.0 0.32 11.1 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 CDI79071.1 - 2.6e-05 24.8 6.4 0.012 16.1 0.0 5.1 6 0 0 6 6 5 1 AAA domain Dynamin_N PF00350.23 CDI79071.1 - 0.00022 21.3 7.1 0.09 12.8 0.0 3.9 4 0 0 4 4 4 2 Dynamin family AAA_28 PF13521.6 CDI79071.1 - 0.00025 21.3 6.8 0.027 14.7 0.1 3.5 4 0 0 4 4 3 2 AAA domain AAA_22 PF13401.6 CDI79071.1 - 0.00052 20.3 6.3 0.25 11.6 0.3 4.2 3 2 1 4 4 4 2 AAA domain NACHT PF05729.12 CDI79071.1 - 0.00078 19.4 0.2 1.3 8.9 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.6 CDI79071.1 - 0.00099 18.9 21.7 0.072 12.8 0.3 4.2 2 1 1 3 3 3 2 AAA ATPase domain AAA_24 PF13479.6 CDI79071.1 - 0.0045 16.7 0.2 1.9 8.2 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 CDI79071.1 - 0.0064 16.5 0.0 6.2 6.9 0.0 3.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDI79071.1 - 0.014 15.8 0.0 7.1 7.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 CDI79071.1 - 0.015 14.7 0.2 1.3 8.3 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Arf PF00025.21 CDI79071.1 - 0.015 14.8 0.1 0.71 9.3 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family MeaB PF03308.16 CDI79071.1 - 0.021 13.8 0.0 3.1 6.7 0.0 2.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_10 PF05176.14 CDI79071.1 - 0.043 13.1 0.2 0.043 13.1 0.2 1.9 2 0 0 2 2 2 0 ATP10 protein NB-ARC PF00931.22 CDI79071.1 - 0.045 12.9 0.0 5.7 6.0 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 CDI79071.1 - 0.059 13.9 0.1 0.059 13.9 0.1 4.8 3 2 0 4 4 3 0 AAA domain AAA_16 PF13191.6 CDI79071.1 - 0.076 13.4 6.1 4 7.8 0.0 3.4 3 1 0 3 3 2 0 AAA ATPase domain ATP-synt_ab PF00006.25 CDI79071.1 - 0.11 12.1 0.0 0.38 10.4 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.15 CDI79071.1 - 0.14 12.1 0.1 23 4.9 0.0 2.9 2 0 0 2 2 2 0 NTPase ATP_bind_1 PF03029.17 CDI79071.1 - 0.14 11.9 0.3 8.4 6.1 0.1 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Seryl_tRNA_N PF02403.22 CDI79071.1 - 0.18 12.0 0.0 0.18 12.0 0.0 3.8 4 0 0 4 4 2 0 Seryl-tRNA synthetase N-terminal domain DUF87 PF01935.17 CDI79071.1 - 4 7.5 8.6 2.9 7.9 0.1 3.5 2 1 1 3 3 3 0 Helicase HerA, central domain DUF1764 PF08576.10 CDI79071.1 - 9.2 7.2 10.2 4.1 8.4 3.9 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) PseudoU_synth_2 PF00849.22 CDI79072.1 - 0.00039 20.5 0.0 0.00094 19.3 0.0 1.7 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDI79072.1 - 0.0012 18.6 0.2 0.0025 17.5 0.0 1.7 2 0 0 2 2 2 1 S4 domain DUF755 PF05501.11 CDI79072.1 - 0.008 16.5 9.1 0.008 16.5 9.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI79072.1 - 1.7 8.2 20.3 2.7 7.5 20.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Alba PF01918.21 CDI79074.1 - 2.4e-16 59.3 0.1 3.5e-16 58.8 0.1 1.3 1 0 0 1 1 1 1 Alba FoP_duplication PF13865.6 CDI79074.1 - 0.018 15.6 3.7 0.041 14.4 3.7 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Rpp20 PF12328.8 CDI79074.1 - 0.031 14.2 1.5 0.046 13.7 0.1 2.0 2 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P MCM PF00493.23 CDI79075.1 - 2.1e-70 236.3 0.2 2.6e-69 232.7 0.2 2.1 1 1 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDI79075.1 - 6.1e-14 52.2 0.5 1.2e-13 51.2 0.5 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 CDI79075.1 - 8.1e-10 38.4 0.5 3.7e-09 36.3 0.5 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI MCM_OB PF17207.3 CDI79075.1 - 6.8e-07 29.2 0.3 0.003 17.4 0.2 2.5 1 1 1 2 2 2 2 MCM OB domain AAA_5 PF07728.14 CDI79075.1 - 4.7e-06 26.6 0.0 1.9e-05 24.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI79075.1 - 0.0049 17.3 0.2 0.0049 17.3 0.2 3.8 3 2 0 4 4 3 1 AAA ATPase domain AAA PF00004.29 CDI79075.1 - 0.0061 17.0 0.0 0.022 15.2 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDI79075.1 - 0.0091 15.7 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Sigma54_activat PF00158.26 CDI79075.1 - 0.01 15.6 0.5 0.029 14.1 0.5 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 CDI79075.1 - 0.02 14.8 0.0 0.15 11.9 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDI79075.1 - 0.051 12.7 0.1 0.13 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Roc PF08477.13 CDI79075.1 - 0.054 13.7 0.1 0.25 11.6 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 CDI79075.1 - 0.064 13.5 0.7 0.19 12.0 0.0 2.2 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDI79075.1 - 0.17 11.8 0.2 0.43 10.5 0.2 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 CDI79075.1 - 0.19 11.2 0.0 0.43 10.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SUIM_assoc PF16619.5 CDI79075.1 - 0.56 10.3 27.1 0.78 9.9 0.6 3.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 KCNQ2_u3 PF16642.5 CDI79075.1 - 3.1 8.9 6.7 29 5.7 0.1 3.5 3 0 0 3 3 3 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Spt20 PF12090.8 CDI79075.1 - 5.4 6.5 14.7 5.6 6.5 1.5 3.1 3 0 0 3 3 3 0 Spt20 family YajC PF02699.15 CDI79075.1 - 8.1 6.4 12.4 0.4 10.6 1.7 3.2 3 0 0 3 3 3 0 Preprotein translocase subunit DUF2722 PF10846.8 CDI79076.1 - 0.00095 18.2 9.0 0.00095 18.2 9.0 8.8 8 2 0 8 8 8 3 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI79076.1 - 0.0022 17.6 4.1 0.0022 17.6 4.1 6.7 5 2 1 6 6 6 3 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI79076.1 - 0.009 16.3 16.0 0.009 16.3 16.0 12.0 12 1 1 13 13 13 2 Domain of unknown function (DUF755) Amidohydro_1 PF01979.20 CDI79076.1 - 0.63 9.3 4.4 0.59 9.4 3.1 1.5 2 0 0 2 2 2 0 Amidohydrolase family UPF0054 PF02130.17 CDI79077.1 - 7.3e-12 45.2 0.0 5.1e-11 42.5 0.0 2.3 2 1 0 2 2 2 1 Uncharacterized protein family UPF0054 ACPS PF01648.20 CDI79077.1 - 1.7e-11 44.2 0.7 1.2e-08 35.1 0.0 2.9 2 1 1 3 3 3 2 4'-phosphopantetheinyl transferase superfamily DUF3446 PF11928.8 CDI79078.1 - 0.045 14.1 0.9 0.045 14.1 0.9 5.8 3 2 2 5 5 5 0 Early growth response N-terminal domain Med3 PF11593.8 CDI79078.1 - 1.5 7.9 37.9 0.39 9.8 1.3 3.2 3 0 0 3 3 3 0 Mediator complex subunit 3 fungal UCR_Fe-S_N PF10399.9 CDI79079.1 - 0.0025 17.1 1.4 0.0025 17.1 1.4 2.9 2 1 0 2 2 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Claudin_2 PF13903.6 CDI79079.1 - 0.006 16.4 0.1 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2157 PF09925.9 CDI79079.1 - 0.021 14.6 0.3 0.11 12.3 0.1 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) UCR_TM PF02921.14 CDI79079.1 - 0.025 15.1 9.5 0.2 12.1 0.0 3.0 3 0 0 3 3 3 0 Ubiquinol cytochrome reductase transmembrane region Spt20 PF12090.8 CDI79079.1 - 0.12 12.0 4.6 0.15 11.6 4.6 1.3 1 0 0 1 1 1 0 Spt20 family Trp_oprn_chp PF09534.10 CDI79079.1 - 0.15 11.9 19.4 5.5 6.7 19.4 2.0 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) UPF0093 PF03653.13 CDI79079.1 - 0.19 12.0 0.0 0.34 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0093) RIFIN PF02009.16 CDI79079.1 - 0.23 11.3 6.3 0.3 10.9 6.3 1.2 1 0 0 1 1 1 0 Rifin DUF677 PF05055.12 CDI79079.1 - 1.3 7.8 5.4 1 8.2 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF677) TFIIA PF03153.13 CDI79079.1 - 2.2 8.2 12.2 2.7 7.9 12.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPPK_C PF12555.8 CDI79079.1 - 2.4 8.3 14.4 6 7.0 4.3 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal LAMTOR PF15454.6 CDI79079.1 - 2.5 8.8 8.8 1.9 9.2 1.1 2.7 3 0 0 3 3 3 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Pex14_N PF04695.13 CDI79079.1 - 5.9 7.5 13.0 16 6.1 13.0 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 CDI79080.1 - 0.0078 15.8 18.4 0.0078 15.8 18.4 6.9 3 1 2 6 6 6 1 Nuclear RNA-splicing-associated protein rve PF00665.26 CDI79081.1 - 2.4e-10 40.6 0.0 4.2e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDI79081.1 - 0.012 15.4 0.1 0.023 14.4 0.1 1.5 1 0 0 1 1 1 0 Integrase core domain SecM PF06558.12 CDI79081.1 - 0.035 14.2 0.2 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Secretion monitor precursor protein (SecM) EF-hand_7 PF13499.6 CDI79082.1 - 2e-29 101.9 3.8 4.3e-09 36.7 0.1 4.8 4 0 0 4 4 4 4 EF-hand domain pair Metallophos PF00149.28 CDI79082.1 - 5.2e-22 79.3 0.3 1.1e-21 78.3 0.3 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 CDI79082.1 - 1.5e-17 61.7 11.6 0.00051 19.4 0.1 8.1 9 0 0 9 9 9 4 EF hand EF-hand_6 PF13405.6 CDI79082.1 - 2.9e-16 57.9 5.3 0.013 15.4 0.2 7.8 7 1 0 7 7 7 3 EF-hand domain EF-hand_8 PF13833.6 CDI79082.1 - 2.7e-14 52.8 10.8 2.2e-09 37.0 0.2 5.4 6 0 0 6 6 6 2 EF-hand domain pair CAP_GLY PF01302.25 CDI79082.1 - 3.4e-11 43.0 1.1 6.6e-11 42.1 1.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain PPP5 PF08321.12 CDI79082.1 - 1.5e-05 25.2 0.0 4.8e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region EF-hand_5 PF13202.6 CDI79082.1 - 8.6e-05 21.9 6.1 0.046 13.2 0.1 5.3 5 0 0 5 5 5 1 EF hand EF-hand_11 PF08976.11 CDI79082.1 - 0.00033 21.5 0.0 0.04 14.8 0.0 4.0 3 1 1 4 4 4 1 EF-hand domain Erf4 PF10256.9 CDI79082.1 - 0.12 12.4 0.3 0.74 9.9 0.0 2.4 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family EF-hand_4 PF12763.7 CDI79082.1 - 0.36 10.8 1.5 17 5.4 0.0 3.6 2 2 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand DUF4820 PF16091.5 CDI79083.1 - 8.3 5.7 25.4 0.2 11.0 9.8 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) ECH_2 PF16113.5 CDI79084.1 - 8.2e-23 81.4 0.1 2.3e-21 76.6 0.1 2.4 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase zf-met PF12874.7 CDI79085.1 - 9.5e-05 22.7 0.1 0.00017 21.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Hamartin PF04388.12 CDI79085.1 - 7.9 5.0 43.4 15 4.1 43.4 1.3 1 0 0 1 1 1 0 Hamartin protein Cyclin_C PF02984.19 CDI79087.1 - 1.9e-05 24.7 2.2 0.0045 17.1 0.0 3.8 3 0 0 3 3 3 1 Cyclin, C-terminal domain TFIIA PF03153.13 CDI79087.1 - 0.00023 21.3 13.2 0.0055 16.7 6.2 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI79087.1 - 0.024 13.3 15.5 0.19 10.4 8.1 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.14 CDI79087.1 - 0.042 13.8 7.8 0.05 13.6 2.5 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CDI79087.1 - 0.13 11.8 25.6 0.33 10.5 0.9 2.2 2 0 0 2 2 2 0 Spt20 family RAB3GAP2_N PF14655.6 CDI79087.1 - 0.54 9.5 5.6 7.8 5.6 1.7 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Mak10 PF04112.13 CDI79087.1 - 2.5 7.6 8.5 2 7.9 0.2 2.4 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase SR-25 PF10500.9 CDI79088.1 - 0.0025 17.4 5.7 0.0025 17.4 5.7 23.1 20 4 1 21 21 21 6 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI79088.1 - 0.005 16.9 0.3 0.005 16.9 0.3 15.6 5 4 4 12 12 12 3 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI79088.1 - 0.19 10.6 0.0 0.19 10.6 0.0 21.3 17 7 4 21 21 21 0 Protein of unknown function (DUF2722) FATC PF02260.20 CDI79091.1 - 0.00054 19.7 0.1 0.00093 19.0 0.1 1.4 1 0 0 1 1 1 1 FATC domain DUF4647 PF15504.6 CDI79091.1 - 0.0089 15.2 6.3 0.0089 15.2 6.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) SUIM_assoc PF16619.5 CDI79091.1 - 0.015 15.3 24.7 0.23 11.5 6.4 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF3379 PF11859.8 CDI79091.1 - 0.1 11.9 4.7 0.16 11.3 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) Presenilin PF01080.17 CDI79091.1 - 0.22 10.3 4.7 0.26 10.0 4.7 1.2 1 0 0 1 1 1 0 Presenilin MPM1 PF17234.2 CDI79091.1 - 0.27 11.5 7.7 2.2 8.5 1.4 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF3761 PF12587.8 CDI79091.1 - 0.72 10.3 4.0 0.25 11.8 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) YihI PF04220.12 CDI79091.1 - 0.83 9.4 11.3 7.8 6.2 11.3 2.0 1 1 0 1 1 1 0 Der GTPase activator (YihI) TFIIA PF03153.13 CDI79091.1 - 0.89 9.5 18.8 1.3 9.0 18.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Inj_translocase PF16928.5 CDI79091.1 - 8.9 5.7 18.6 2.4 7.6 6.0 2.1 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome zf-ANAPC11 PF12861.7 CDI79092.1 - 3.8e-22 78.2 5.7 5e-22 77.8 5.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CDI79092.1 - 1.7e-18 66.6 11.5 2.6e-18 66.1 11.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDI79092.1 - 4.8e-06 26.8 12.4 5.2e-05 23.5 12.4 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDI79092.1 - 8.2e-05 22.4 6.1 0.00016 21.5 6.1 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI79092.1 - 0.00014 21.7 9.5 0.00057 19.8 9.6 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDI79092.1 - 0.029 14.4 10.5 0.042 13.9 8.6 2.2 1 1 1 2 2 2 0 RING-type zinc-finger Pellino PF04710.14 CDI79092.1 - 0.048 12.3 0.2 0.056 12.1 0.2 1.2 1 0 0 1 1 1 0 Pellino zf-C3HC4_3 PF13920.6 CDI79092.1 - 0.054 13.4 10.2 1.1 9.2 10.2 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDI79092.1 - 0.12 12.6 9.2 14 5.9 9.2 2.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 CDI79092.1 - 0.27 11.4 5.7 0.61 10.3 3.0 2.3 2 0 0 2 2 2 0 RING-variant domain Prok-RING_4 PF14447.6 CDI79092.1 - 1.3 8.9 10.8 6.3 6.7 10.7 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 CDI79092.1 - 2.1 8.1 11.5 12 5.6 11.5 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HIT PF04438.16 CDI79092.1 - 2.8 7.9 9.6 0.45 10.4 4.8 2.0 2 0 0 2 2 2 0 HIT zinc finger RecR PF02132.15 CDI79092.1 - 4.7 6.9 7.4 4.7 6.8 3.3 2.3 2 0 0 2 2 2 0 RecR protein FYDLN_acid PF09538.10 CDI79092.1 - 6.5 7.5 9.1 0.14 12.9 2.4 1.6 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) zf-C3HC4_2 PF13923.6 CDI79092.1 - 7.4 6.5 16.6 3.6e+02 1.1 16.6 3.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDI79092.1 - 8.2 6.7 14.0 55 4.0 14.0 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 CDI79092.1 - 9.8 6.2 10.0 93 3.0 10.0 2.3 1 1 0 1 1 1 0 PHD-finger Cys_Met_Meta_PP PF01053.20 CDI79095.1 - 3.4e-115 384.6 0.0 1.7e-65 221.0 0.0 2.0 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDI79095.1 - 2e-06 27.4 0.0 5.3e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CDI79095.1 - 0.035 13.3 0.0 0.059 12.5 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II SUIM_assoc PF16619.5 CDI79097.1 - 0.063 13.4 5.6 0.19 11.8 5.6 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Rad60-SLD_2 PF13881.6 CDI79097.1 - 0.14 12.3 1.1 0.5 10.5 0.5 2.2 2 1 1 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like RuvX PF03652.15 CDI79098.1 - 8.4e-06 26.2 0.0 8.4e-06 26.2 0.0 4.0 4 1 0 4 4 3 2 Holliday junction resolvase Connexin PF00029.19 CDI79098.1 - 0.014 15.2 12.7 0.033 14.0 3.2 2.2 2 0 0 2 2 2 0 Connexin MDM10 PF12519.8 CDI79098.1 - 0.059 12.2 14.9 0.084 11.7 14.9 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PTPRCAP PF15713.5 CDI79098.1 - 0.064 13.5 24.5 0.071 13.4 2.5 2.8 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CSG2 PF16965.5 CDI79098.1 - 0.073 12.0 7.5 0.081 11.9 0.9 2.2 2 0 0 2 2 2 0 Ceramide synthase regulator Eapp_C PF10238.9 CDI79098.1 - 0.14 12.3 18.0 0.055 13.5 7.0 2.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 CDI79098.1 - 0.54 10.4 16.6 1.2 9.3 7.3 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal BatD PF13584.6 CDI79098.1 - 0.63 8.8 14.1 0.03 13.1 5.4 2.1 2 0 0 2 2 2 0 Oxygen tolerance AUX_IAA PF02309.16 CDI79098.1 - 0.93 9.3 13.7 0.26 11.1 9.9 1.8 1 1 1 2 2 2 0 AUX/IAA family B12D PF06522.11 CDI79098.1 - 0.96 9.3 0.0 0.96 9.3 0.0 2.6 2 0 0 2 2 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF2370 PF10176.9 CDI79098.1 - 2 8.0 8.8 0.64 9.6 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF4366 PF14283.6 CDI79098.1 - 2.7 8.0 8.3 4.1 7.4 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4471 PF14740.6 CDI79098.1 - 4.6 6.4 12.8 2.2 7.4 6.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) GOLD_2 PF13897.6 CDI79098.1 - 4.8 7.7 7.2 1.4e+02 2.9 0.0 3.1 3 0 0 3 3 3 0 Golgi-dynamics membrane-trafficking Nucleoside_tran PF01733.18 CDI79098.1 - 5.1 6.4 6.0 0.37 10.1 0.4 1.7 2 0 0 2 2 2 0 Nucleoside transporter DUF3043 PF11241.8 CDI79098.1 - 5.8 6.9 15.6 0.094 12.7 1.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3043) PBP1_TM PF14812.6 CDI79098.1 - 6.3 7.2 10.2 0.48 10.8 3.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM91_C PF14648.6 CDI79098.1 - 7.7 5.2 10.4 0.86 8.4 3.3 2.1 2 0 0 2 2 2 0 FAM91 C-terminus Pex2_Pex12 PF04757.14 CDI79099.1 - 7.9e-18 64.9 5.6 1.9e-17 63.6 5.6 1.6 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region DUF4471 PF14740.6 CDI79099.1 - 0.0025 17.1 3.9 0.0025 17.1 3.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4471) Zip PF02535.22 CDI79099.1 - 2.7 7.1 3.8 6.2 5.9 3.8 1.7 1 1 0 1 1 1 0 ZIP Zinc transporter GHMP_kinases_N PF00288.26 CDI79099.1 - 3.6 7.9 8.0 9.3 6.6 8.0 1.7 1 0 0 1 1 1 0 GHMP kinases N terminal domain Mg_trans_NIPA PF05653.14 CDI79100.1 - 8.8e-11 41.4 8.6 2e-07 30.5 0.7 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA Spt46 PF17734.1 CDI79100.1 - 0.074 12.9 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Spermatogenesis-associated protein 46 Sod_Fe_C PF02777.18 CDI79102.1 - 5.5e-19 68.2 0.1 1.1e-18 67.2 0.1 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDI79102.1 - 0.00022 21.7 0.0 0.00058 20.3 0.0 1.8 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain SUIM_assoc PF16619.5 CDI79102.1 - 0.04 14.0 4.6 0.079 13.0 4.6 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI79102.1 - 0.16 12.0 6.5 0.18 11.8 6.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NrsF PF06532.11 CDI79102.1 - 0.21 11.3 16.7 0.33 10.6 16.7 1.3 1 0 0 1 1 1 0 Negative regulator of sigma F DUF5585 PF17823.1 CDI79102.1 - 7.4 5.4 17.7 9.9 5.0 17.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5585) RskA PF10099.9 CDI79103.1 - 0.00064 20.1 2.5 0.00064 20.1 2.5 13.2 4 4 4 8 8 8 2 Anti-sigma-K factor rskA Sec62 PF03839.16 CDI79103.1 - 0.0018 17.9 0.0 0.0018 17.9 0.0 4.5 4 0 0 4 4 4 1 Translocation protein Sec62 DUF2249 PF10006.9 CDI79103.1 - 2.1 8.3 6.0 28 4.7 0.2 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2249) Ank_2 PF12796.7 CDI79105.1 - 6.5e-12 45.9 2.5 4.4e-07 30.4 0.6 3.3 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI79105.1 - 3.3e-07 30.4 6.5 0.006 16.9 0.1 4.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI79105.1 - 2.6e-06 27.8 6.4 0.00011 22.7 0.2 4.2 3 2 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI79105.1 - 3.4e-05 23.9 8.5 0.0099 16.3 0.2 5.9 7 0 0 7 7 6 1 Ankyrin repeat RLL PF10036.9 CDI79105.1 - 0.0048 16.8 4.2 0.011 15.7 4.2 1.6 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein TFIIA PF03153.13 CDI79105.1 - 0.073 13.1 17.6 0.13 12.2 17.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI79105.1 - 0.078 11.5 3.0 0.16 10.5 3.0 1.4 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 CDI79105.1 - 0.52 8.3 11.1 0.79 7.7 11.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Lin-8 PF03353.15 CDI79105.1 - 0.69 9.4 8.7 1 8.8 8.7 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Sporozoite_P67 PF05642.11 CDI79105.1 - 1.2 7.1 6.1 2.8 5.9 6.1 1.6 1 1 0 1 1 1 0 Sporozoite P67 surface antigen SUIM_assoc PF16619.5 CDI79105.1 - 1.8 8.7 26.8 3.4 7.8 11.4 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L10 PF00466.20 CDI79107.1 - 8.5e-12 45.1 0.4 1.2e-11 44.6 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Baculo_FP PF03258.14 CDI79107.1 - 0.018 15.2 0.4 0.035 14.3 0.4 1.4 1 0 0 1 1 1 0 Baculovirus FP protein Pkinase PF00069.25 CDI79108.1 - 1.3e-09 37.8 17.5 4.1e-06 26.4 0.0 6.0 7 0 0 7 7 7 3 Protein kinase domain SR-25 PF10500.9 CDI79108.1 - 0.0022 17.6 9.9 0.0022 17.6 9.9 16.5 12 5 2 16 16 16 3 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI79108.1 - 0.0045 17.3 20.1 0.0069 16.7 11.6 20.9 7 4 9 16 16 16 4 Anti-sigma-K factor rskA BT1 PF03092.16 CDI79108.1 - 0.024 12.9 0.9 0.21 9.7 0.0 2.8 2 0 0 2 2 2 0 BT1 family SR-25 PF10500.9 CDI79109.1 - 0.0067 16.1 5.8 0.0067 16.1 5.8 9.2 7 3 3 10 10 10 1 Nuclear RNA-splicing-associated protein Mito_carr PF00153.27 CDI79109.1 - 7.3 6.6 5.9 3.3 7.7 0.5 3.4 2 0 0 2 2 2 0 Mitochondrial carrier protein Pyr_redox_2 PF07992.14 CDI79110.1 - 1.6e-35 122.8 0.9 1.4e-31 109.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDI79110.1 - 1.2e-23 83.5 0.0 3.8e-23 81.8 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDI79110.1 - 1.3e-13 51.3 0.0 1.3e-13 51.3 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI79110.1 - 8.2e-08 31.9 2.9 1.6e-06 27.6 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CDI79110.1 - 0.00038 19.7 0.0 0.0013 17.9 0.0 1.8 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Proteasome PF00227.26 CDI79111.1 - 1.4e-22 80.1 0.1 1.6e-22 79.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Ribonuc_red_sm PF00268.21 CDI79112.1 - 3.1e-114 381.2 0.4 3.9e-114 380.8 0.4 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain BROMI PF14961.6 CDI79112.1 - 0.035 11.5 0.2 0.047 11.1 0.2 1.1 1 0 0 1 1 1 0 Broad-minded protein cobW PF02492.19 CDI79113.1 - 6.7e-35 120.3 0.2 1.3e-34 119.3 0.2 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CDI79113.1 - 8.2e-05 23.1 1.7 8.2e-05 23.1 1.7 2.4 2 2 0 2 2 1 1 AAA ATPase domain AAA_33 PF13671.6 CDI79113.1 - 0.00024 21.3 0.3 0.00091 19.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain SUIM_assoc PF16619.5 CDI79113.1 - 0.0031 17.6 18.6 0.0053 16.8 0.9 3.6 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 RsgA_GTPase PF03193.16 CDI79113.1 - 0.0043 17.0 1.8 1.5 8.7 0.1 2.8 2 1 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 CDI79113.1 - 0.0046 16.9 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 CDI79113.1 - 0.012 16.2 7.2 0.048 14.1 0.2 3.0 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 CDI79113.1 - 0.025 14.8 3.1 0.13 12.5 0.6 2.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDI79113.1 - 0.038 14.5 0.0 0.098 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDI79113.1 - 0.038 14.5 0.7 0.15 12.6 0.2 2.1 2 1 0 2 2 2 0 ABC transporter SET PF00856.28 CDI79113.1 - 0.043 14.2 5.9 3.2 8.1 4.0 3.1 2 1 0 2 2 2 0 SET domain LpoB PF13036.6 CDI79113.1 - 0.051 13.5 3.1 0.37 10.7 0.0 2.4 2 0 0 2 2 2 0 Peptidoglycan-synthase activator LpoB DUF4111 PF13427.6 CDI79113.1 - 0.12 12.6 0.4 0.12 12.6 0.4 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4111) AAA_14 PF13173.6 CDI79113.1 - 0.15 12.1 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF4123 PF13503.6 CDI79113.1 - 0.16 12.4 0.2 0.16 12.4 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4123) NACHT PF05729.12 CDI79113.1 - 3.2 7.7 8.8 0.28 11.1 1.6 2.6 3 1 1 4 4 2 0 NACHT domain Inj_translocase PF16928.5 CDI79113.1 - 4.8 6.6 14.8 1.1 8.7 1.2 2.7 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome Calc_CGRP_IAPP PF00214.19 CDI79113.1 - 6 7.3 19.7 1.1 9.7 4.0 3.2 3 0 0 3 3 3 0 Calcitonin / CGRP / IAPP family Ribosomal_60s PF00428.19 CDI79113.1 - 6.6 7.4 35.8 0.55 10.8 9.9 3.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein Spt20 PF12090.8 CDI79113.1 - 7.9 6.0 19.0 0.2 11.2 1.9 2.7 2 1 0 2 2 2 0 Spt20 family TPR_1 PF00515.28 CDI79114.1 - 1.5e-16 59.4 5.8 1.1e-05 25.0 0.1 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDI79114.1 - 8.2e-15 53.7 9.3 0.00042 20.2 0.2 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDI79114.1 - 1.5e-10 40.5 5.9 8.5e-05 22.2 0.3 5.3 3 2 3 6 6 6 3 TPR repeat TPR_8 PF13181.6 CDI79114.1 - 3.1e-08 33.2 1.6 0.0067 16.5 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDI79114.1 - 2.4e-07 30.6 6.1 0.012 15.9 0.3 5.4 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF1645 PF07816.11 CDI79114.1 - 0.00027 21.6 9.5 0.00027 21.6 9.5 7.1 6 3 0 6 6 6 1 Protein of unknown function (DUF1645) TPR_7 PF13176.6 CDI79114.1 - 0.0006 19.7 0.8 0.73 10.0 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI79114.1 - 0.011 16.5 0.2 0.12 13.3 0.1 14.5 17 2 1 18 18 18 0 Tetratricopeptide repeat Pet20 PF08692.10 CDI79114.1 - 0.24 12.1 0.0 0.24 12.1 0.0 5.7 5 2 0 5 5 5 0 Mitochondrial protein Pet20 ANAPC3 PF12895.7 CDI79114.1 - 2.6 8.3 12.5 0.52 10.6 0.0 4.1 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Questin_oxidase PF14027.6 CDI79115.1 - 0.049 13.2 1.0 0.16 11.5 0.0 2.1 2 0 0 2 2 2 0 Questin oxidase-like PAT1 PF09770.9 CDI79115.1 - 0.2 9.9 13.1 0.53 8.5 13.1 1.7 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Velvet PF11754.8 CDI79115.1 - 8.3 6.3 11.3 11 5.9 4.4 3.0 2 1 0 2 2 2 0 Velvet factor Molydop_binding PF01568.21 CDI79116.1 - 0.038 14.0 0.0 0.21 11.6 0.0 1.9 1 1 1 2 2 2 0 Molydopterin dinucleotide binding domain CDC48_N PF02359.18 CDI79116.1 - 0.047 13.9 0.0 2.8 8.2 0.0 2.2 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain Ribosomal_60s PF00428.19 CDI79118.1 - 2.9e-22 79.0 12.0 3.5e-22 78.8 12.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein VPS9 PF02204.18 CDI79121.1 - 1.8e-27 95.6 0.1 4.6e-27 94.3 0.0 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain CCSAP PF15748.5 CDI79122.1 - 5.1e-05 23.6 6.8 5.1e-05 23.6 6.8 5.4 5 0 0 5 5 5 1 Centriole, cilia and spindle-associated TCP PF03634.13 CDI79122.1 - 8.3e-05 23.2 8.8 8.3e-05 23.2 8.8 6.1 5 2 2 7 7 7 1 TCP family transcription factor Pkinase PF00069.25 CDI79122.1 - 0.00063 19.2 3.1 0.12 11.7 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain O-antigen_lig PF13425.6 CDI79122.1 - 0.0019 17.1 3.4 0.0019 17.1 0.7 2.1 2 0 0 2 2 2 1 O-antigen ligase like membrane protein SUIM_assoc PF16619.5 CDI79122.1 - 0.007 16.4 5.5 0.007 16.4 5.5 7.9 5 1 1 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 Zip PF02535.22 CDI79122.1 - 0.11 11.7 21.7 0.03 13.5 2.7 3.4 3 0 0 3 3 3 0 ZIP Zinc transporter Endostatin PF06482.11 CDI79122.1 - 0.35 10.3 27.8 0.064 12.7 7.7 3.5 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 CDI79122.1 - 0.59 8.2 39.4 0.019 13.2 8.6 3.2 3 0 0 3 3 3 0 High-temperature-induced dauer-formation protein NPR3 PF03666.13 CDI79122.1 - 0.72 8.6 40.4 0.032 13.0 10.9 3.3 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2852 PF11014.8 CDI79122.1 - 7.9 6.7 13.7 1.5 9.0 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2852) DUF2722 PF10846.8 CDI79124.1 - 3e-05 23.2 16.9 0.0072 15.3 3.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Hydin_ADK PF17213.3 CDI79124.1 - 0.0043 17.4 0.3 0.0043 17.4 0.3 4.0 5 0 0 5 5 4 1 Hydin Adenylate kinase-like domain TFIIA PF03153.13 CDI79124.1 - 0.006 16.6 12.6 0.006 16.6 12.6 4.2 4 0 0 4 4 4 2 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI79124.1 - 0.038 14.4 8.6 0.78 10.1 3.0 2.9 2 0 0 2 2 2 0 Enhancer of polycomb-like Afi1 PF07792.12 CDI79124.1 - 0.17 12.4 7.5 1.6 9.2 3.7 2.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking HNOBA PF07701.14 CDI79124.1 - 0.37 10.2 7.3 8.2 5.8 0.1 3.2 3 0 0 3 3 3 0 Heme NO binding associated SpoIIP PF07454.11 CDI79124.1 - 0.72 9.3 10.6 0.41 10.1 3.2 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Suf PF05843.14 CDI79124.1 - 1.2 9.1 15.3 3.4 7.6 2.4 2.9 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PIP5K PF01504.18 CDI79124.1 - 1.2 8.3 6.1 7.8 5.6 3.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Zip PF02535.22 CDI79124.1 - 2.3 7.4 6.1 1.8 7.7 2.9 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Presenilin PF01080.17 CDI79124.1 - 2.3 6.9 17.6 0.45 9.2 4.0 3.3 3 0 0 3 3 3 0 Presenilin Eapp_C PF10238.9 CDI79124.1 - 3.4 7.7 13.3 1.3 9.1 2.9 3.2 3 0 0 3 3 3 0 E2F-associated phosphoprotein MecA PF05389.12 CDI79124.1 - 4.5 6.8 7.3 17 4.9 0.1 2.5 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) YEATS PF03366.16 CDI79125.1 - 9.1e-08 32.0 0.0 2.1e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 YEATS family TFIIA PF03153.13 CDI79125.1 - 0.0054 16.8 43.1 0.0069 16.4 43.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit FAM220 PF15487.6 CDI79125.1 - 9.3 5.8 10.9 14 5.2 10.9 1.2 1 0 0 1 1 1 0 FAM220 family RNA_pol_A_bac PF01000.26 CDI79126.1 - 0.00013 22.3 0.0 0.00047 20.5 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RskA PF10099.9 CDI79126.1 - 0.003 17.9 0.0 0.003 17.9 0.0 5.7 3 2 1 4 4 2 1 Anti-sigma-K factor rskA Otopetrin PF03189.13 CDI79126.1 - 0.078 11.8 0.7 0.13 11.1 0.7 1.3 1 0 0 1 1 1 0 Otopetrin RNA_pol_L PF01193.24 CDI79126.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.5 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain GREB1 PF15782.5 CDI79126.1 - 0.15 9.2 10.4 0.24 8.5 10.4 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF913 PF06025.12 CDI79126.1 - 0.45 9.4 7.5 1.3 8.0 7.5 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI79126.1 - 0.46 8.8 3.6 0.71 8.2 3.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Bul1_N PF04425.12 CDI79126.1 - 0.54 9.0 13.1 0.97 8.1 13.1 1.3 1 0 0 1 1 1 0 Bul1 N terminus CLN3 PF02487.17 CDI79126.1 - 0.56 9.2 10.5 1.2 8.1 10.5 1.5 1 0 0 1 1 1 0 CLN3 protein Membralin PF09746.9 CDI79126.1 - 0.62 9.0 6.1 1.1 8.3 6.1 1.3 1 0 0 1 1 1 0 Tumour-associated protein Connexin PF00029.19 CDI79126.1 - 0.68 9.7 12.2 2 8.1 12.2 1.7 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 CDI79126.1 - 1 9.3 6.4 3 7.7 6.4 1.7 1 0 0 1 1 1 0 N-glycosylation protein FAM60A PF15396.6 CDI79126.1 - 1.1 9.3 15.0 0.29 11.1 10.8 2.2 2 0 0 2 2 2 0 Protein Family FAM60A LMBR1 PF04791.16 CDI79126.1 - 1.1 8.1 3.0 1.6 7.6 3.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2126 PF09899.9 CDI79126.1 - 2.8 5.9 12.8 6.3 4.7 12.8 1.5 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4471 PF14740.6 CDI79126.1 - 3.9 6.6 11.1 8.5 5.5 11.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) FemAB PF02388.16 CDI79126.1 - 4.5 6.0 16.7 12 4.7 16.7 1.6 1 0 0 1 1 1 0 FemAB family SLC12 PF03522.15 CDI79126.1 - 5.9 5.8 17.9 0.34 9.9 12.3 1.7 2 0 0 2 2 2 0 Solute carrier family 12 CDC45 PF02724.14 CDI79126.1 - 6.7 4.9 15.5 0.48 8.7 10.1 1.7 2 0 0 2 2 2 0 CDC45-like protein DUF1917 PF08939.10 CDI79126.1 - 7.4 6.4 17.9 17 5.2 16.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1917) CAF1 PF04857.20 CDI79126.1 - 7.9 5.5 14.0 39 3.3 11.0 2.8 3 0 0 3 3 3 0 CAF1 family ribonuclease DUF4638 PF15472.6 CDI79126.1 - 9 5.9 15.1 20 4.8 15.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF2370 PF10176.9 CDI79126.1 - 9.4 5.8 8.5 24 4.5 8.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) EIIBC-GUT_N PF03612.14 CDI79126.1 - 9.9 5.9 17.7 0.14 11.9 7.5 3.2 4 0 0 4 4 2 0 Sorbitol phosphotransferase enzyme II N-terminus Zip PF02535.22 CDI79126.1 - 10 5.3 7.3 27 3.9 7.3 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter SDA1 PF05285.12 CDI79127.1 - 0.0019 17.7 10.6 0.0022 17.5 10.6 1.0 1 0 0 1 1 1 1 SDA1 TFIIA PF03153.13 CDI79127.1 - 0.018 15.1 34.2 0.023 14.7 34.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 CDI79127.1 - 0.028 12.5 30.6 0.034 12.3 30.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SprA-related PF12118.8 CDI79127.1 - 0.038 13.1 34.4 0.055 12.6 34.4 1.2 1 0 0 1 1 1 0 SprA-related family Suf PF05843.14 CDI79127.1 - 0.057 13.4 19.9 0.074 13.0 19.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) NAM-associated PF14303.6 CDI79127.1 - 0.074 13.8 22.6 0.097 13.4 22.6 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain MAP70 PF07058.11 CDI79127.1 - 0.11 11.3 11.4 0.12 11.1 11.4 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Smg4_UPF3 PF03467.15 CDI79127.1 - 0.14 12.2 0.0 0.14 12.2 0.0 2.4 2 1 0 2 2 1 0 Smg-4/UPF3 family PA26 PF04636.13 CDI79127.1 - 0.16 10.9 14.0 0.19 10.6 14.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Rgp1 PF08737.10 CDI79127.1 - 0.22 10.7 15.9 0.24 10.5 15.9 1.1 1 0 0 1 1 1 0 Rgp1 DUF966 PF06136.13 CDI79127.1 - 0.22 11.2 22.6 0.25 11.0 22.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) LAP1C PF05609.12 CDI79127.1 - 0.27 10.3 21.2 0.31 10.1 21.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) eIF-3_zeta PF05091.12 CDI79127.1 - 0.27 10.2 17.7 0.3 10.0 17.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI79127.1 - 0.45 10.4 18.5 0.64 9.9 18.5 1.4 1 0 0 1 1 1 0 Velvet factor Exonuc_VII_L PF02601.15 CDI79127.1 - 0.71 9.4 16.4 0.76 9.3 16.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCSAP PF15748.5 CDI79127.1 - 0.72 10.0 28.6 0.96 9.6 28.6 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF853 PF05872.12 CDI79127.1 - 0.78 8.3 10.4 0.85 8.1 10.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Hamartin PF04388.12 CDI79127.1 - 0.78 8.3 20.6 0.89 8.1 20.6 1.1 1 0 0 1 1 1 0 Hamartin protein Corona_nucleoca PF00937.18 CDI79127.1 - 0.8 8.7 21.9 0.93 8.5 21.9 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF4407 PF14362.6 CDI79127.1 - 0.91 8.8 13.3 1.1 8.6 13.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 CDI79127.1 - 0.99 7.2 11.3 1.1 7.0 11.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI79127.1 - 1 9.2 18.7 1.3 8.8 18.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ureide_permease PF07168.11 CDI79127.1 - 1 8.1 7.5 1.7 7.3 7.5 1.3 1 0 0 1 1 1 0 Ureide permease SOG2 PF10428.9 CDI79127.1 - 1.2 8.3 25.5 1.3 8.1 25.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein PPP4R2 PF09184.11 CDI79127.1 - 1.2 8.6 16.6 1.5 8.3 16.6 1.1 1 0 0 1 1 1 0 PPP4R2 DUF572 PF04502.13 CDI79127.1 - 1.5 8.4 21.6 1.8 8.1 21.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) XRCC4 PF06632.12 CDI79127.1 - 1.7 7.4 17.7 2.2 7.0 17.7 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SOBP PF15279.6 CDI79127.1 - 1.7 9.2 25.7 2.1 8.9 25.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Peptidase_S64 PF08192.11 CDI79127.1 - 1.9 6.9 17.9 2.3 6.6 17.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Het-C PF07217.11 CDI79127.1 - 1.9 6.9 11.9 2.2 6.7 11.9 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C MCU PF04678.13 CDI79127.1 - 2.3 8.3 11.2 3.1 7.9 11.2 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter GREB1 PF15782.5 CDI79127.1 - 2.4 5.2 23.4 2.5 5.1 23.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 CDI79127.1 - 2.6 7.0 17.5 3 6.8 17.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI79127.1 - 3.6 5.8 17.4 4.3 5.5 17.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SR-25 PF10500.9 CDI79127.1 - 4 7.0 39.7 16 5.0 39.7 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med3 PF11593.8 CDI79127.1 - 4.2 6.5 36.4 8.2 5.5 36.4 1.5 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal Zip PF02535.22 CDI79127.1 - 4.2 6.5 10.4 5.2 6.2 10.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5427 PF10310.9 CDI79127.1 - 4.5 6.1 26.2 5.5 5.8 26.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Hid1 PF12722.7 CDI79127.1 - 5.1 5.1 23.1 5.4 5.0 23.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 CDI79127.1 - 7 5.2 24.0 9 4.9 24.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LMBR1 PF04791.16 CDI79127.1 - 9 5.1 10.8 9.8 4.9 10.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein MecA PF05389.12 CDI79128.1 - 0.019 14.6 8.3 0.19 11.3 5.5 2.7 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) TFIIA PF03153.13 CDI79128.1 - 0.075 13.0 66.7 11 5.9 52.5 2.3 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 CDI79128.1 - 0.47 9.8 26.2 0.83 8.9 11.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RskA PF10099.9 CDI79128.1 - 0.91 9.8 51.9 0.53 10.6 11.8 3.4 2 1 0 3 3 3 0 Anti-sigma-K factor rskA Peroxin-13_N PF04088.13 CDI79128.1 - 4 7.7 8.9 38 4.5 0.1 3.3 3 0 0 3 3 3 0 Peroxin 13, N-terminal region EOS1 PF12326.8 CDI79128.1 - 6.1 6.7 9.9 70 3.3 0.0 2.9 2 2 0 2 2 2 0 N-glycosylation protein zf-CCHC_3 PF13917.6 CDI79129.1 - 3.9e-05 23.5 0.3 3.9e-05 23.5 0.3 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 CDI79129.1 - 0.00029 20.8 1.1 0.00045 20.2 1.1 1.3 1 0 0 1 1 1 1 Zinc knuckle SR-25 PF10500.9 CDI79129.1 - 0.063 12.9 42.8 0.093 12.3 42.8 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Neur_chan_memb PF02932.16 CDI79129.1 - 0.38 10.8 6.8 0.46 10.5 6.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 CDI79129.1 - 0.54 10.2 5.0 0.59 10.0 5.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein Peroxin-3 PF04882.12 CDI79129.1 - 0.84 8.6 9.8 0.77 8.7 9.8 1.1 1 0 0 1 1 1 0 Peroxin-3 Presenilin PF01080.17 CDI79129.1 - 1.2 7.8 8.7 1.3 7.7 8.7 1.1 1 0 0 1 1 1 0 Presenilin RNA_polI_A34 PF08208.11 CDI79129.1 - 1.6 8.7 24.6 2.8 8.0 24.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 CDI79129.1 - 2.1 6.5 16.6 2.5 6.3 16.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3827 PF12877.7 CDI79129.1 - 3.9 5.7 13.0 4.2 5.6 13.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Apt1 PF10351.9 CDI79129.1 - 6.1 5.6 15.3 7.3 5.3 15.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4551 PF15087.6 CDI79129.1 - 7.2 5.3 13.7 7.6 5.2 13.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Sox_N PF12444.8 CDI79129.1 - 9.5 7.4 14.4 48 5.2 12.9 2.2 2 0 0 2 2 2 0 Sox developmental protein N terminal SARAF PF06682.12 CDI79130.1 - 1.3 8.6 8.5 1.9 8.0 8.5 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Pex14_N PF04695.13 CDI79131.1 - 0.00049 20.8 43.7 0.00049 20.8 43.7 9.3 5 3 1 6 6 6 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RskA PF10099.9 CDI79131.1 - 0.0026 18.1 8.0 0.0026 18.1 8.0 8.9 2 2 4 6 6 6 1 Anti-sigma-K factor rskA DUF494 PF04361.13 CDI79131.1 - 2.3 8.1 7.4 0.29 11.0 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF494) DNA_pol_B PF00136.21 CDI79132.1 - 5.8e-131 437.3 1.4 9e-131 436.7 1.4 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDI79132.1 - 2.2e-69 234.2 0.0 5e-69 233.0 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CDI79132.1 - 1.4e-17 63.9 6.0 3.7e-17 62.5 6.0 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 CDI79132.1 - 0.0081 15.1 0.1 0.028 13.3 0.0 1.7 1 1 1 2 2 2 1 DNA polymerase type B, organellar and viral zf-RING-like PF08746.11 CDI79132.1 - 8 6.9 10.5 2 8.8 0.4 2.8 3 0 0 3 3 3 0 RING-like domain Mito_carr PF00153.27 CDI79133.1 - 3.5e-52 174.3 0.1 1e-18 67.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Phage_holin_3_6 PF07332.11 CDI79134.1 - 0.16 12.0 3.5 0.18 11.9 1.0 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III RNB PF00773.19 CDI79136.1 - 0.077 12.3 0.4 0.15 11.4 0.4 1.4 1 0 0 1 1 1 0 RNB domain OTU PF02338.19 CDI79138.1 - 3.3e-16 59.9 0.0 6.2e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease ATG7_N PF16420.5 CDI79139.1 - 1e-20 74.6 1.8 5.4e-14 52.5 0.1 4.2 2 1 1 3 3 3 2 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus DUF2722 PF10846.8 CDI79140.1 - 7.4 5.4 12.8 5.8 5.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SRP9-21 PF05486.12 CDI79141.1 - 0.019 15.3 0.1 0.034 14.5 0.1 1.7 1 1 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) SR-25 PF10500.9 CDI79141.1 - 0.022 14.4 7.3 0.025 14.2 7.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI79141.1 - 0.55 10.9 9.4 1.1 10.0 9.4 1.6 1 1 0 1 1 1 0 Immortalisation up-regulated protein Frataxin_Cyay PF01491.16 CDI79142.1 - 2.6e-12 46.8 0.0 4.1e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Frataxin-like domain DUF3446 PF11928.8 CDI79142.1 - 0.033 14.5 5.1 0.033 14.5 5.1 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain Secretin_N_2 PF07655.13 CDI79142.1 - 0.4 11.3 10.8 0.1 13.2 7.7 1.5 2 0 0 2 2 2 0 Secretin N-terminal domain LZ_Tnp_IS66 PF13007.7 CDI79142.1 - 0.4 11.5 2.1 1.1 10.1 2.1 1.8 1 1 0 1 1 1 0 Transposase C of IS166 homeodomain AF-4 PF05110.13 CDI79142.1 - 0.5 8.4 12.7 0.64 8.0 12.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TraT PF05818.12 CDI79142.1 - 1.7 8.3 7.0 2.9 7.5 7.0 1.4 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein Sugar_tr PF00083.24 CDI79143.1 - 3.1e-86 290.0 22.8 3.6e-86 289.8 22.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDI79143.1 - 3.9e-36 124.7 56.2 5e-26 91.5 32.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDI79143.1 - 0.00091 17.6 3.0 0.00091 17.6 3.0 1.8 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Holin_SPP1 PF04688.13 CDI79143.1 - 5 7.4 7.3 6.1 7.1 1.8 3.2 2 0 0 2 2 2 0 SPP1 phage holin DUF5345 PF17280.2 CDI79143.1 - 7.4 6.6 6.2 3.2 7.8 0.6 3.1 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Nop14 PF04147.12 CDI79144.1 - 0.067 11.4 1.1 0.14 10.4 1.1 1.5 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 CDI79144.1 - 8.1 4.9 13.5 12 4.3 13.5 1.2 1 0 0 1 1 1 0 Macoilin family Clathrin PF00637.20 CDI79145.1 - 2.4e-170 559.2 21.9 7.2e-30 103.7 0.7 7.7 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 CDI79145.1 - 3.5e-27 94.1 0.1 1.6e-26 92.0 0.1 2.3 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.20 CDI79145.1 - 2.4e-09 37.1 0.0 1.2e-05 25.4 0.0 4.5 4 0 0 4 4 4 1 Clathrin propeller repeat Coatomer_WDAD PF04053.14 CDI79145.1 - 1.7e-05 24.1 6.1 0.36 9.8 0.0 3.7 4 0 0 4 4 4 3 Coatomer WD associated region TPR_1 PF00515.28 CDI79145.1 - 1.2 9.0 6.0 80 3.3 0.3 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat LSM PF01423.22 CDI79148.1 - 1e-19 70.0 0.0 1.2e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 CDI79148.1 - 0.017 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain NUDIX PF00293.28 CDI79149.1 - 0.00052 20.1 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain HydF_tetramer PF18133.1 CDI79149.1 - 0.056 13.2 0.2 0.097 12.4 0.2 1.3 1 0 0 1 1 1 0 Hydrogen maturase F tetramerization domain BRF1 PF07741.13 CDI79149.1 - 0.24 11.8 3.4 0.46 10.8 3.4 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain MRP-L46 PF11788.8 CDI79149.1 - 0.65 10.8 7.7 1.7 9.4 7.7 1.8 1 1 0 1 1 1 0 39S mitochondrial ribosomal protein L46 DEAD PF00270.29 CDI79150.1 - 5.2e-45 153.4 0.1 7.1e-45 152.9 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79150.1 - 3.1e-29 101.6 0.9 1.7e-28 99.2 0.3 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 CDI79150.1 - 0.0064 16.8 0.1 0.011 16.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 CDI79150.1 - 0.04 13.2 0.1 0.086 12.2 0.1 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit MMR_HSR1 PF01926.23 CDI79151.1 - 5e-31 107.1 0.0 4.4e-19 68.7 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 CDI79151.1 - 1.9e-26 92.2 0.0 5.1e-26 90.8 0.0 1.8 2 0 0 2 2 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 CDI79151.1 - 8.8e-13 48.1 0.0 1.4e-09 37.6 0.0 2.6 3 0 0 3 3 3 2 Ferrous iron transport protein B Dynamin_N PF00350.23 CDI79151.1 - 1e-10 41.9 0.3 0.0015 18.6 0.1 3.3 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 CDI79151.1 - 1.2e-10 41.3 0.1 0.00013 21.6 0.0 4.1 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 CDI79151.1 - 8.2e-08 31.8 0.1 8.8e-05 21.9 0.1 2.4 2 1 0 2 2 2 2 AIG1 family Gtr1_RagA PF04670.12 CDI79151.1 - 1.9e-05 24.2 0.0 0.016 14.5 0.0 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDI79151.1 - 4.8e-05 23.3 0.3 0.059 13.3 0.0 3.8 5 0 0 5 5 5 1 RsgA GTPase Roc PF08477.13 CDI79151.1 - 0.0013 18.9 0.0 0.0039 17.4 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI79151.1 - 0.011 15.2 0.2 0.15 11.5 0.1 2.5 2 1 0 2 2 2 0 ADP-ribosylation factor family Ras PF00071.22 CDI79151.1 - 0.011 15.3 0.0 0.06 12.9 0.0 2.2 2 1 0 2 2 2 0 Ras family Nuc_deoxyrib_tr PF05014.15 CDI79151.1 - 0.047 13.7 0.0 6.2 6.9 0.0 2.6 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase UPF0113 PF03657.13 CDI79152.1 - 4.6e-17 62.1 0.0 6.7e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain UPF0113_N PF17833.1 CDI79152.1 - 2.8e-10 40.6 0.1 4.7e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain Rota_NSP3 PF01665.16 CDI79153.1 - 0.2 10.7 0.5 0.3 10.2 0.5 1.1 1 0 0 1 1 1 0 Rotavirus non-structural protein NSP3 OmpH PF03938.14 CDI79153.1 - 0.39 11.0 6.3 0.71 10.2 6.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Pkinase PF00069.25 CDI79154.1 - 1e-44 152.9 0.0 2e-44 152.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79154.1 - 2.9e-27 95.6 0.0 4.9e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI79154.1 - 0.0029 16.4 0.0 0.0029 16.4 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 CDI79154.1 - 0.16 11.8 0.1 0.16 11.8 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Prenyltrans PF00432.21 CDI79156.1 - 1.2e-16 60.1 20.6 4.1e-09 36.0 0.1 6.6 7 0 0 7 7 7 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CDI79156.1 - 0.046 12.8 0.0 0.16 11.1 0.0 1.8 3 0 0 3 3 3 0 Squalene-hopene cyclase N-terminal domain CSD PF00313.22 CDI79158.1 - 3.1e-23 81.4 0.3 4.3e-23 80.9 0.3 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDI79158.1 - 0.0032 17.1 0.2 0.0067 16.1 0.2 1.6 1 1 0 1 1 1 1 Ribonuclease B OB domain PP2C PF00481.21 CDI79160.1 - 1.4e-25 90.4 0.1 5.1e-16 59.1 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 CDI79160.1 - 5e-05 23.3 0.0 0.00012 22.0 0.0 1.7 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CDI79160.1 - 0.00031 20.4 0.0 0.0023 17.6 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C Histone PF00125.24 CDI79165.1 - 2.6e-15 56.9 0.0 3e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 CDI79165.1 - 0.00031 21.2 0.0 0.00051 20.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 CDI79165.1 - 0.0023 18.2 0.1 0.0045 17.2 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone WD40_alt PF14077.6 CDI79170.1 - 0.16 11.8 0.3 27 4.7 0.0 2.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif Asp PF00026.23 CDI79171.1 - 2.2e-40 139.0 3.2 2.1e-24 86.5 0.0 2.5 2 1 1 3 3 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDI79171.1 - 6.9e-06 26.4 0.3 6.9e-06 26.4 0.3 2.6 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal Otopetrin PF03189.13 CDI79171.1 - 0.034 13.0 0.5 0.037 12.9 0.5 1.1 1 0 0 1 1 1 0 Otopetrin EPL1 PF10513.9 CDI79171.1 - 0.17 12.2 9.4 0.36 11.2 9.4 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like TFIIA PF03153.13 CDI79171.1 - 0.28 11.2 30.1 0.58 10.1 30.1 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI79171.1 - 0.77 10.4 17.7 0.31 11.7 14.7 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 PF09770.9 CDI79171.1 - 0.79 7.9 20.0 1.1 7.4 20.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sec62 PF03839.16 CDI79171.1 - 0.92 9.0 9.8 1.4 8.3 9.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 FAM60A PF15396.6 CDI79171.1 - 1.5 8.8 8.9 2.5 8.1 8.9 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 CDI79171.1 - 2 7.4 11.2 2.8 6.9 11.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4407 PF14362.6 CDI79171.1 - 2.1 7.6 10.8 4.7 6.5 10.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Band_3_cyto PF07565.13 CDI79171.1 - 2.2 8.0 13.8 3.7 7.3 13.8 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MMR1 PF08505.10 CDI79171.1 - 4.1 7.6 16.9 7.7 6.7 16.9 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF2126 PF09899.9 CDI79171.1 - 4.4 5.2 8.2 6.4 4.7 8.2 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Presenilin PF01080.17 CDI79171.1 - 6.2 5.5 17.1 9.4 4.9 17.1 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI79171.1 - 8.1 6.4 10.9 14 5.7 10.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 CDI79171.1 - 8.3 5.5 11.0 14 4.7 11.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter BORG_CEP PF14957.6 CDI79171.1 - 8.9 7.5 8.5 19 6.4 8.5 1.5 1 0 0 1 1 1 0 Cdc42 effector TMEM72 PF16054.5 CDI79172.1 - 0.22 11.2 8.9 0.069 12.8 2.0 2.2 2 0 0 2 2 2 0 Transmembrane protein family 72 PRELI PF04707.14 CDI79173.1 - 1.1e-33 116.2 0.0 1.9e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 PRELI-like family FXMRP1_C_core PF12235.8 CDI79173.1 - 0.14 12.8 0.2 0.14 12.8 0.2 1.9 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal SR-25 PF10500.9 CDI79173.1 - 0.67 9.5 14.3 0.015 14.9 5.7 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI79174.1 - 0.022 14.8 16.6 0.35 11.0 4.9 3.3 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 tRNA-synt_1b PF00579.25 CDI79176.1 - 4.3e-08 32.8 9.9 1.7e-07 30.8 6.7 2.7 3 0 0 3 3 3 1 tRNA synthetases class I (W and Y) S4 PF01479.25 CDI79176.1 - 3.1e-05 23.6 0.0 6.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 S4 domain Macoilin PF09726.9 CDI79176.1 - 0.00021 20.0 15.1 0.00021 20.0 15.1 2.1 2 0 0 2 2 2 2 Macoilin family BUD22 PF09073.10 CDI79176.1 - 0.00022 20.7 14.3 0.00022 20.7 14.3 2.2 2 0 0 2 2 2 1 BUD22 Lin-8 PF03353.15 CDI79176.1 - 0.004 16.8 28.5 0.004 16.8 28.5 2.3 2 0 0 2 2 2 1 Ras-mediated vulval-induction antagonist Peptidase_S64 PF08192.11 CDI79176.1 - 0.074 11.5 32.9 0.0054 15.3 22.9 2.1 2 0 0 2 2 2 0 Peptidase family S64 Ribosomal_L5e PF17144.4 CDI79176.1 - 0.14 12.2 2.7 0.55 10.2 2.7 2.1 1 1 0 1 1 1 0 Ribosomal large subunit proteins 60S L5, and 50S L18 GAGA_bind PF06217.12 CDI79176.1 - 3.3 7.9 23.4 12 6.0 19.0 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Ecl1 PF12855.7 CDI79176.1 - 4.5 8.4 32.5 2.4 9.3 24.4 2.4 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins Solute_trans_a PF03619.16 CDI79177.1 - 1.9e-29 103.0 4.0 1.3e-21 77.3 0.3 3.1 2 1 1 3 3 3 3 Organic solute transporter Ostalpha Ccdc124 PF06244.12 CDI79179.1 - 3.1e-32 111.8 28.0 2.9e-29 102.2 28.0 2.3 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 CDI79179.1 - 0.00019 21.8 0.3 0.00019 21.8 0.3 2.6 2 1 0 2 2 2 1 HMG (high mobility group) box CHDNT PF08073.12 CDI79179.1 - 0.0095 15.9 0.2 0.016 15.2 0.2 1.3 1 0 0 1 1 1 1 CHDNT (NUC034) domain Mem_trans PF03547.18 CDI79179.1 - 0.5 8.7 1.5 0.57 8.5 1.5 1.0 1 0 0 1 1 1 0 Membrane transport protein YABBY PF04690.13 CDI79179.1 - 1.4 9.4 13.0 42 4.6 13.0 2.3 1 1 0 1 1 1 0 YABBY protein SecD-TM1 PF13721.6 CDI79179.1 - 5.1 7.6 7.8 3.9 8.0 0.3 2.4 1 1 1 2 2 2 0 SecD export protein N-terminal TM region Golgin_A5 PF09787.9 CDI79180.1 - 0.17 11.3 25.6 0.018 14.5 18.7 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Spc7 PF08317.11 CDI79180.1 - 0.18 10.7 24.5 0.33 9.8 16.7 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 CDI79180.1 - 0.4 10.7 25.0 0.36 10.9 4.3 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 CDI79180.1 - 0.97 9.8 25.1 0.049 14.1 17.5 2.2 1 1 1 2 2 2 0 Fez1 DUF1216 PF06746.11 CDI79180.1 - 0.99 9.4 5.4 2.5 8.1 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) DUF641 PF04859.12 CDI79180.1 - 2.7 8.3 15.0 1.7 9.0 9.7 2.7 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Fzo_mitofusin PF04799.13 CDI79180.1 - 3.1 7.3 6.6 4.8 6.7 6.1 1.6 1 1 0 1 1 1 0 fzo-like conserved region DUF1664 PF07889.12 CDI79180.1 - 3.9 7.5 9.7 12 6.0 4.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 CDI79180.1 - 7.2 6.3 19.4 0.9 9.2 7.9 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) CREPT PF16566.5 CDI79180.1 - 7.9 6.6 13.3 0.46 10.6 7.8 1.8 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TSC22 PF01166.18 CDI79180.1 - 9.5 6.6 9.9 0.35 11.2 1.2 2.7 3 0 0 3 3 2 0 TSC-22/dip/bun family WD40 PF00400.32 CDI79181.1 - 8.1e-09 36.0 2.6 1e-05 26.1 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat MCU PF04678.13 CDI79181.1 - 8.3 6.5 5.3 17 5.5 5.3 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF2973 PF11189.8 CDI79182.1 - 1.4 9.0 5.5 0.71 10.0 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2973) STAC2_u1 PF16664.5 CDI79182.1 - 7 7.1 9.9 6.1 7.3 8.8 1.5 1 1 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 AP2 PF00847.20 CDI79183.1 - 3.6e-22 78.3 14.7 4.3e-10 39.7 2.6 5.3 3 0 0 3 3 3 3 AP2 domain ACDC PF14733.6 CDI79183.1 - 6.1e-07 29.7 0.9 5.5e-06 26.6 0.9 2.7 1 1 0 1 1 1 1 AP2-coincident C-terminal SMAP PF15477.6 CDI79183.1 - 3.9e-06 27.7 0.0 3.9e-06 27.7 0.0 10.6 11 1 0 11 11 11 1 Small acidic protein family RLL PF10036.9 CDI79185.1 - 3.2e-56 191.0 4.5 3.7e-56 190.8 4.5 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein DUF2722 PF10846.8 CDI79185.1 - 0.00023 20.2 6.3 0.00029 19.9 6.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF4778 PF16008.5 CDI79185.1 - 0.00043 20.5 1.6 0.00065 19.8 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4778) TFIIA PF03153.13 CDI79185.1 - 0.0026 17.8 10.0 0.0037 17.3 10.0 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI79185.1 - 0.022 14.9 0.3 0.025 14.8 0.3 1.3 1 0 0 1 1 1 0 DDHD domain Spt20 PF12090.8 CDI79185.1 - 0.032 13.8 16.8 0.059 13.0 16.8 1.4 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI79185.1 - 0.046 14.7 3.6 0.087 13.8 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TMEM51 PF15345.6 CDI79185.1 - 0.064 13.1 4.3 0.099 12.5 4.3 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 TERB2 PF15101.6 CDI79185.1 - 0.064 13.3 3.8 0.1 12.7 3.8 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 UPF0560 PF10577.9 CDI79185.1 - 0.13 10.8 9.4 0.17 10.4 9.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Suf PF05843.14 CDI79185.1 - 0.28 11.1 4.2 0.44 10.5 4.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RskA PF10099.9 CDI79185.1 - 0.35 11.1 35.4 0.18 12.1 19.3 2.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Orf78 PF06024.12 CDI79185.1 - 0.39 11.1 1.4 0.65 10.3 1.4 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Presenilin PF01080.17 CDI79185.1 - 0.66 8.7 2.9 0.84 8.3 2.9 1.1 1 0 0 1 1 1 0 Presenilin FTZ PF03867.14 CDI79185.1 - 0.73 9.3 6.7 1.5 8.3 6.7 1.4 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Pex14_N PF04695.13 CDI79185.1 - 1.2 9.8 13.5 0.14 12.8 8.9 1.8 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NARP1 PF12569.8 CDI79185.1 - 1.5 7.6 9.6 0.19 10.6 5.7 1.4 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 ORC_WH_C PF18137.1 CDI79185.1 - 1.6 8.8 7.2 3.6 7.6 7.2 1.6 1 1 0 1 1 1 0 Origin recognition complex winged helix C-terminal Roughex PF06020.11 CDI79185.1 - 1.7 7.7 8.4 2.3 7.3 8.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein WASH-7_C PF14746.6 CDI79185.1 - 1.7 8.3 6.2 2.9 7.6 6.2 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal PGM_PMM_I PF02878.16 CDI79186.1 - 2.3e-11 43.5 0.1 1.9e-06 27.6 0.0 2.9 3 0 0 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I RskA PF10099.9 CDI79186.1 - 4.5 7.5 48.5 6.7 7.0 11.0 5.0 2 1 1 3 3 3 0 Anti-sigma-K factor rskA PC_rep PF01851.22 CDI79190.1 - 4.2e-09 36.4 3.4 0.079 13.4 0.1 5.0 4 0 0 4 4 4 3 Proteasome/cyclosome repeat DUF2722 PF10846.8 CDI79190.1 - 0.00081 18.4 2.0 0.00081 18.4 2.0 14.8 12 2 0 12 12 12 7 Protein of unknown function (DUF2722) Dynein_AAA_lid PF17852.1 CDI79190.1 - 0.19 11.8 3.8 8.4 6.5 0.0 4.1 3 0 0 3 3 3 0 Dynein heavy chain AAA lid domain Spt20 PF12090.8 CDI79192.1 - 1.5e-05 24.7 13.1 1.5e-05 24.7 13.1 4.0 4 0 0 4 4 4 2 Spt20 family DUF2722 PF10846.8 CDI79192.1 - 0.0023 17.0 7.8 0.0023 17.0 7.8 4.2 3 1 0 3 3 3 1 Protein of unknown function (DUF2722) TPR_1 PF00515.28 CDI79192.1 - 0.093 12.6 2.9 12 5.9 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI79192.1 - 0.15 12.3 10.9 1.4 9.2 0.5 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat SR-25 PF10500.9 CDI79194.1 - 0.015 14.9 61.1 0.016 14.8 7.6 4.9 5 0 0 5 5 5 0 Nuclear RNA-splicing-associated protein GTP_EFTU PF00009.27 CDI79196.1 - 5.3e-24 84.8 0.0 2e-23 83.0 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDI79196.1 - 0.00014 21.9 0.0 0.0054 16.8 0.0 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase eIF3_subunit PF08597.10 CDI79196.1 - 0.00049 20.1 16.9 0.00049 20.1 16.9 2.4 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit Dynamin_N PF00350.23 CDI79196.1 - 0.0095 16.0 0.0 0.0095 16.0 0.0 3.6 3 1 1 4 4 4 1 Dynamin family TM_helix PF05552.12 CDI79196.1 - 0.018 15.0 0.2 0.041 13.9 0.2 1.6 1 0 0 1 1 1 0 Conserved TM helix RsgA_GTPase PF03193.16 CDI79196.1 - 0.042 13.8 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase V_ATPase_I PF01496.19 CDI79196.1 - 0.12 10.2 10.6 0.15 9.9 3.7 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Septin PF00735.18 CDI79196.1 - 0.25 10.6 0.1 0.25 10.6 0.1 2.0 2 0 0 2 2 2 0 Septin PAP2 PF01569.21 CDI79196.1 - 0.57 9.9 0.0 0.57 9.9 0.0 2.9 3 0 0 3 3 3 0 PAP2 superfamily DUF2722 PF10846.8 CDI79197.1 - 0.0045 16.0 0.3 0.0045 16.0 0.3 12.3 12 1 0 12 12 12 5 Protein of unknown function (DUF2722) Viral_Beta_CD PF04530.12 CDI79197.1 - 8.4 6.7 6.3 38 4.6 6.3 2.2 1 0 0 1 1 1 0 Viral Beta C/D like family MMS19_N PF14500.6 CDI79198.1 - 3.3e-30 105.5 0.6 3.3e-30 105.5 0.6 4.1 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 CDI79198.1 - 0.12 12.7 3.3 0.32 11.4 0.3 3.7 2 0 0 2 2 2 0 HEAT repeat RRM_1 PF00076.22 CDI79199.1 - 1.5e-14 53.5 0.1 4.3e-14 52.1 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CDI79199.1 - 0.0048 16.7 7.2 0.21 11.4 0.0 3.1 3 1 1 4 4 4 2 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 CDI79199.1 - 0.0065 16.3 0.0 0.023 14.5 0.0 1.9 1 0 0 1 1 1 1 Occluded RNA-recognition motif Roughex PF06020.11 CDI79199.1 - 3.9 6.5 18.2 0.12 11.4 9.0 2.0 2 0 0 2 2 2 0 Drosophila roughex protein OKR_DC_1 PF01276.20 CDI79200.1 - 4.8e-71 239.7 0.0 3.4e-53 180.9 0.0 2.2 2 0 0 2 2 2 2 Orn/Lys/Arg decarboxylase, major domain Spt20 PF12090.8 CDI79200.1 - 0.00016 21.3 2.3 0.00026 20.7 2.3 1.3 1 0 0 1 1 1 1 Spt20 family Beta_elim_lyase PF01212.21 CDI79200.1 - 0.00023 20.6 0.0 0.00043 19.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1_C PF03711.15 CDI79200.1 - 0.008 16.5 1.7 0.012 15.8 0.1 2.1 1 1 1 2 2 2 1 Orn/Lys/Arg decarboxylase, C-terminal domain ACAS_N PF16177.5 CDI79201.1 - 4.4e-14 52.1 1.4 7.4e-14 51.4 1.4 1.3 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus SUIM_assoc PF16619.5 CDI79201.1 - 0.0084 16.1 5.6 0.016 15.3 5.6 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 E1-E2_ATPase PF00122.20 CDI79202.1 - 1.5e-34 119.1 3.7 2e-34 118.7 0.1 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDI79202.1 - 3.1e-34 118.3 0.9 3.1e-34 118.3 0.9 3.9 5 1 0 5 5 5 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CDI79202.1 - 1.4e-16 61.5 0.1 6.1e-10 39.7 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI79202.1 - 1e-13 51.1 0.1 2.4e-13 50.0 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDI79202.1 - 2.1e-07 30.5 0.0 7.7e-07 28.7 0.0 2.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDI79202.1 - 0.00032 20.5 0.6 0.0018 18.1 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PAP_central PF04928.17 CDI79202.1 - 0.15 11.0 0.2 0.32 9.9 0.2 1.5 1 0 0 1 1 1 0 Poly(A) polymerase central domain MMtag PF10159.9 CDI79203.1 - 2.7e-18 66.0 1.9 2.7e-18 66.0 1.9 3.5 4 0 0 4 4 4 1 Multiple myeloma tumor-associated FUSC_2 PF13515.6 CDI79204.1 - 1.6e-09 37.9 15.1 1.6e-09 37.9 15.1 4.3 3 2 1 4 4 4 1 Fusaric acid resistance protein-like DUF1082 PF06449.11 CDI79204.1 - 0.082 12.7 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1082) F-box PF00646.33 CDI79205.1 - 0.024 14.5 0.0 0.45 10.5 0.0 2.7 2 0 0 2 2 2 0 F-box domain WD40 PF00400.32 CDI79205.1 - 0.25 12.3 4.7 4.8 8.2 0.2 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat Foie-gras_1 PF11817.8 CDI79206.1 - 1.1e-06 28.4 0.1 2.4e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 STT3 PF02516.14 CDI79207.1 - 4.2e-82 276.6 28.6 6.2e-82 276.1 28.6 1.2 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit MAP17 PF15807.5 CDI79207.1 - 0.41 10.9 1.8 0.97 9.7 1.8 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 BT1 PF03092.16 CDI79208.1 - 3.4e-58 197.2 16.6 9.1e-31 106.7 5.9 2.2 2 0 0 2 2 2 2 BT1 family MFS_1 PF07690.16 CDI79208.1 - 3.6e-15 55.8 33.4 4.9e-15 55.3 33.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5418 PF17439.2 CDI79208.1 - 0.033 14.3 1.6 0.092 12.8 1.6 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5418) IpaB_EvcA PF03278.13 CDI79208.1 - 0.13 11.9 0.3 0.24 11.1 0.3 1.3 1 0 0 1 1 1 0 IpaB/EvcA family DUF2273 PF10031.9 CDI79208.1 - 0.23 11.5 1.5 0.89 9.6 0.3 2.5 1 1 1 2 2 2 0 Small integral membrane protein (DUF2273) zf-CDGSH PF09360.10 CDI79209.1 - 1.4e-08 34.9 0.3 1.4e-08 34.9 0.3 1.7 2 0 0 2 2 2 1 Iron-binding zinc finger CDGSH type MMR_HSR1 PF01926.23 CDI79210.1 - 5.3e-18 65.2 0.2 2.7e-15 56.4 0.0 3.1 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CDI79210.1 - 9.5e-07 28.5 0.1 2.6e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDI79210.1 - 2.6e-06 27.4 0.0 0.0056 16.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDI79210.1 - 0.08 13.0 0.6 0.36 10.9 0.1 2.3 2 1 0 2 2 2 0 Dynamin family Med4 PF10018.9 CDI79211.1 - 0.0032 17.2 2.2 0.072 12.8 0.7 2.1 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 TelA PF05816.11 CDI79211.1 - 0.0051 15.9 0.5 0.0051 15.9 0.5 1.5 2 0 0 2 2 2 1 Toxic anion resistance protein (TelA) Sec2p PF06428.11 CDI79211.1 - 0.0056 16.6 1.9 0.0056 16.6 1.9 2.4 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p Phage_GP20 PF06810.11 CDI79211.1 - 0.029 14.2 3.2 0.038 13.8 0.3 2.0 2 0 0 2 2 2 0 Phage minor structural protein GP20 SKA1 PF07160.12 CDI79211.1 - 0.03 14.2 1.0 0.75 9.6 0.3 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 OmpH PF03938.14 CDI79211.1 - 0.047 14.0 7.2 0.058 13.7 2.5 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) PAH PF02671.21 CDI79211.1 - 0.063 13.4 0.2 0.12 12.6 0.2 1.5 1 0 0 1 1 1 0 Paired amphipathic helix repeat Jnk-SapK_ap_N PF09744.9 CDI79211.1 - 0.084 13.1 4.6 0.25 11.5 0.5 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 WHEP-TRS PF00458.20 CDI79211.1 - 0.11 12.6 2.8 0.19 11.9 2.8 1.3 1 0 0 1 1 1 0 WHEP-TRS domain Prefoldin_2 PF01920.20 CDI79211.1 - 0.13 12.2 5.6 0.45 10.5 2.2 2.4 2 0 0 2 2 2 0 Prefoldin subunit DUF536 PF04394.14 CDI79211.1 - 0.36 10.7 9.7 0.85 9.5 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function, DUF536 Exonuc_VII_L PF02601.15 CDI79211.1 - 0.7 9.4 4.7 1.1 8.7 4.7 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Prefoldin PF02996.17 CDI79211.1 - 0.79 9.7 5.4 13 5.7 1.4 2.3 2 0 0 2 2 2 0 Prefoldin subunit Csm1_N PF18504.1 CDI79211.1 - 8.4 6.8 8.4 3.3 8.1 4.1 2.4 2 1 0 2 2 2 0 Csm1 N-terminal domain Alpha-E PF04168.12 CDI79212.1 - 0.011 15.5 1.2 0.011 15.5 1.2 2.3 3 0 0 3 3 3 0 A predicted alpha-helical domain with a conserved ER motif. CREPT PF16566.5 CDI79212.1 - 0.038 14.2 7.8 0.13 12.5 7.8 1.8 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Plasmid_parti PF01672.16 CDI79212.1 - 0.31 11.7 3.6 2.7 8.7 2.7 2.5 3 0 0 3 3 3 0 Putative plasmid partition protein T7SS_ESX_EspC PF10824.8 CDI79212.1 - 0.49 10.9 12.0 3 8.4 0.0 2.9 2 1 1 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm FapA PF03961.13 CDI79212.1 - 0.52 8.9 4.4 1 7.9 4.4 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF334 PF03904.13 CDI79212.1 - 1.3 8.5 4.6 2.4 7.6 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Fib_alpha PF08702.10 CDI79212.1 - 1.7 8.8 7.8 1.4 9.0 3.4 2.6 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 CDI79212.1 - 2.5 7.2 4.4 4.3 6.5 4.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein AKNA PF12443.8 CDI79212.1 - 7.2 7.3 13.4 0.13 12.9 1.3 3.6 3 0 0 3 3 3 0 AT-hook-containing transcription factor Acetyltransf_1 PF00583.25 CDI79213.1 - 1.2e-07 32.0 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Bromodomain PF00439.25 CDI79213.1 - 1.2e-07 31.6 0.0 3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_10 PF13673.7 CDI79213.1 - 4.1e-06 26.8 0.0 9.2e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDI79213.1 - 9.7e-05 22.7 0.1 0.00022 21.6 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Bac_GH3_C PF18034.1 CDI79213.1 - 0.032 14.0 0.1 0.073 12.8 0.1 1.5 1 0 0 1 1 1 0 Bacterial Glycosyl hydrolase family 3 C-terminal domain FR47 PF08445.10 CDI79213.1 - 0.039 13.9 0.0 0.087 12.8 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 CDI79213.1 - 0.14 12.2 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain IMP2_N PF18590.1 CDI79214.1 - 2.8e-28 98.3 0.0 3.8e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain IMP2_C PF18591.1 CDI79214.1 - 3.9e-23 81.1 0.0 6e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) C-terminal domain CobT PF06213.12 CDI79216.1 - 0.002 17.5 12.8 0.002 17.5 12.8 7.7 7 2 0 7 7 7 3 Cobalamin biosynthesis protein CobT MORN PF02493.20 CDI79219.1 - 1.8e-46 153.3 61.5 7e-08 31.9 1.0 9.5 9 0 0 9 9 9 9 MORN repeat Dehydrin PF00257.19 CDI79219.1 - 0.039 14.5 0.8 0.039 14.5 0.8 4.8 3 2 1 4 4 4 0 Dehydrin DUF3048_C PF17479.2 CDI79219.1 - 1.9 8.9 11.1 35 4.8 0.2 3.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain Trp_oprn_chp PF09534.10 CDI79221.1 - 0.0029 17.4 1.8 0.0029 17.4 1.8 3.3 3 1 0 3 3 3 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI79221.1 - 0.013 15.8 11.5 0.013 15.8 11.5 3.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF3824 PF12868.7 CDI79221.1 - 0.017 15.8 4.9 0.017 15.8 4.9 4.4 4 0 0 4 4 4 0 Domain of unknwon function (DUF3824) SDF PF00375.18 CDI79221.1 - 0.091 11.8 1.2 0.097 11.7 0.0 1.5 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family Mito_carr PF00153.27 CDI79222.1 - 3.2e-37 126.3 9.4 6.7e-18 64.4 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Plasmodium_Vir PF05795.11 CDI79222.1 - 0.25 10.7 3.0 0.35 10.3 0.6 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Connexin PF00029.19 CDI79222.1 - 0.27 10.9 0.7 0.47 10.2 0.7 1.3 1 0 0 1 1 1 0 Connexin PAT1 PF09770.9 CDI79222.1 - 1.6 6.9 10.0 2.2 6.5 10.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PA26 PF04636.13 CDI79222.1 - 2 7.2 4.3 3.8 6.3 4.3 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF1180 PF06679.12 CDI79222.1 - 3.5 8.0 23.8 1.3 9.4 2.5 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) SR-25 PF10500.9 CDI79223.1 - 0.0022 17.7 30.2 0.0022 17.7 30.2 11.5 7 4 2 10 10 10 4 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI79223.1 - 0.016 15.3 0.0 0.016 15.3 0.0 21.9 13 7 4 17 17 17 0 Unstructured region C-term to UIM in Ataxin3 MORN PF02493.20 CDI79226.1 - 0.23 11.4 3.2 2 8.5 0.1 3.4 4 0 0 4 4 4 0 MORN repeat GTP1_OBG PF01018.22 CDI79227.1 - 2.2e-23 82.5 10.1 9.5e-21 74.0 10.1 2.3 1 1 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 CDI79227.1 - 0.00014 21.9 0.0 0.0006 19.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CDI79227.1 - 0.0025 17.3 0.1 0.0054 16.2 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDI79227.1 - 0.0034 17.0 0.1 0.12 11.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF1967 PF09269.11 CDI79227.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) G-alpha PF00503.20 CDI79227.1 - 0.074 12.2 0.0 0.19 10.9 0.0 1.5 2 0 0 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.17 CDI79227.1 - 0.16 11.8 0.3 0.84 9.4 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 CDI79227.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IMS PF00817.20 CDI79230.1 - 2.6e-39 134.6 0.1 7.6e-39 133.1 0.1 1.9 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CDI79230.1 - 2.2e-13 50.9 1.2 9.6e-13 48.9 1.2 2.0 1 1 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDI79230.1 - 0.00062 19.9 0.0 0.0014 18.8 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.8 CDI79230.1 - 0.16 12.2 0.0 0.75 10.1 0.0 2.1 1 0 0 1 1 1 0 Pathogenicity locus PTS_IIB PF02302.17 CDI79230.1 - 0.96 10.2 3.8 0.94 10.2 0.3 2.6 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit Folate_rec PF03024.14 CDI79231.1 - 1.1e-06 28.6 0.5 1.9e-06 27.9 0.5 1.3 1 0 0 1 1 1 1 Folate receptor family Synaphin PF05835.12 CDI79231.1 - 0.044 14.1 5.2 0.067 13.5 5.2 1.2 1 0 0 1 1 1 0 Synaphin protein DUF1828 PF08861.10 CDI79231.1 - 0.21 11.9 0.1 0.36 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF1828 MORN PF02493.20 CDI79233.1 - 7.1e-12 44.5 9.9 0.00045 19.9 0.0 5.5 5 0 0 5 5 5 4 MORN repeat AP2 PF00847.20 CDI79233.1 - 0.15 12.3 0.2 0.33 11.2 0.2 1.5 1 0 0 1 1 1 0 AP2 domain BTK PF00779.19 CDI79236.1 - 0.027 14.3 0.7 0.051 13.4 0.7 1.4 1 0 0 1 1 1 0 BTK motif Post_transc_reg PF13797.6 CDI79237.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Post-transcriptional regulator YodL PF14191.6 CDI79238.1 - 0.1 13.5 0.0 0.18 12.7 0.0 1.3 1 0 0 1 1 1 0 YodL-like NDK PF00334.19 CDI79239.1 - 5.8e-05 23.1 0.0 0.037 14.0 0.0 2.6 2 0 0 2 2 2 2 Nucleoside diphosphate kinase Activator_LAG-3 PF11498.8 CDI79241.1 - 0.32 9.9 17.4 0.4 9.6 17.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ATP-synt_Eps PF04627.13 CDI79242.1 - 1.2e-06 28.4 0.1 5.1e-06 26.4 0.1 2.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Surp PF01805.20 CDI79243.1 - 3.2e-14 52.6 0.1 6.4e-14 51.7 0.1 1.5 1 0 0 1 1 1 1 Surp module cwf21 PF08312.12 CDI79243.1 - 1.5e-12 47.5 4.5 1.5e-12 47.5 4.5 2.3 2 0 0 2 2 2 1 cwf21 domain RRM_1 PF00076.22 CDI79243.1 - 2.6e-05 24.0 0.0 7.7e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.8 CDI79243.1 - 0.0002 21.3 0.0 0.00042 20.3 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 Tubulin PF00091.25 CDI79244.1 - 6.9e-11 42.7 0.0 0.00011 22.5 0.0 2.3 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain E1-E2_ATPase PF00122.20 CDI79245.1 - 8.5e-40 136.2 0.8 2.3e-38 131.6 0.6 2.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDI79245.1 - 3.3e-19 70.0 0.1 7.3e-19 68.9 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDI79245.1 - 1.7e-07 30.8 0.3 3.9e-05 23.3 0.3 2.6 1 1 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CDI79245.1 - 3.5e-05 23.8 0.0 0.0001 22.3 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CDI79245.1 - 0.006 16.4 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.32 CDI79246.1 - 1.4e-13 49.3 0.0 1.5e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CDI79246.1 - 1.9e-13 50.6 0.0 4e-13 49.6 0.0 1.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI79246.1 - 5.3e-12 44.7 0.0 1e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDI79246.1 - 6.8e-09 34.8 0.0 6.1e-06 25.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI79246.1 - 4.4e-08 32.8 0.0 2.7e-05 23.9 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDI79246.1 - 0.00011 22.4 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 CDI79246.1 - 0.019 13.5 0.0 0.023 13.2 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_9 PF14658.6 CDI79246.1 - 0.088 13.1 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain EFhand_Ca_insen PF08726.10 CDI79246.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Ca2+ insensitive EF hand DUF3682 PF12446.8 CDI79248.1 - 1.3e-05 25.6 22.7 1.3e-05 25.6 22.7 15.4 11 3 4 15 15 15 2 Protein of unknown function (DUF3682) SR-25 PF10500.9 CDI79248.1 - 0.0045 16.6 5.0 0.0045 16.6 5.0 7.7 6 2 1 8 8 8 3 Nuclear RNA-splicing-associated protein EFTUD2 PF16004.5 CDI79249.1 - 0.076 13.6 12.6 0.097 13.3 12.6 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Ureide_permease PF07168.11 CDI79249.1 - 1 8.0 4.3 1.1 7.9 4.3 1.1 1 0 0 1 1 1 0 Ureide permease DUF4330 PF14221.6 CDI79249.1 - 3.3 7.9 6.5 3.6 7.8 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) O-antigen_lig PF13425.6 CDI79249.1 - 6.6 5.4 4.7 6.8 5.4 4.7 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RskA PF10099.9 CDI79249.1 - 7.5 6.8 22.6 2.5e+02 1.8 22.6 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Pkinase PF00069.25 CDI79250.1 - 1.6e-23 83.5 5.5 3e-17 62.9 0.0 5.7 4 2 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79250.1 - 2.9e-10 39.9 0.0 1.4e-07 31.1 0.0 3.3 3 0 0 3 3 3 2 Protein tyrosine kinase SRA PF18491.1 CDI79250.1 - 9.3 6.4 8.0 76 3.4 8.0 2.7 1 0 0 1 1 1 0 SET and RING associated domain Ribosomal_L21p PF00829.21 CDI79254.1 - 2.8e-17 62.8 0.0 3.6e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein AC_N PF16214.5 CDI79255.1 - 0.69 9.0 9.8 2.1 7.4 9.8 1.8 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region MSP1_C PF07462.11 CDI79255.1 - 2.1 7.0 7.3 4.7 5.8 7.3 1.5 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus R_equi_Vir PF05526.11 CDI79255.1 - 2.3 8.1 7.9 1.2 9.0 3.2 2.8 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein RAB3GAP2_N PF14655.6 CDI79256.1 - 0.12 11.6 1.4 0.21 10.8 1.4 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIIA PF03153.13 CDI79256.1 - 1.1 9.2 32.0 0.092 12.7 27.2 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit eIF_4EBP PF05456.11 CDI79256.1 - 5 7.1 8.8 4.1 7.4 6.2 2.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) THOC2_N PF16134.5 CDI79256.1 - 6.5 5.3 6.7 9.6 4.7 6.7 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Spt20 PF12090.8 CDI79256.1 - 6.6 6.3 24.8 0.33 10.5 18.3 2.0 3 0 0 3 3 3 0 Spt20 family MgsA_C PF12002.8 CDI79256.1 - 6.9 6.6 11.7 11 6.0 11.7 1.3 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal Apt1 PF10351.9 CDI79256.1 - 10 4.9 15.4 4.1 6.2 7.9 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Ank_2 PF12796.7 CDI79258.1 - 4.4e-09 36.8 0.1 0.00035 21.1 0.0 3.0 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI79258.1 - 5.7e-09 35.5 0.4 0.31 11.7 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 CDI79258.1 - 1.9e-05 25.1 0.9 1.8 9.2 0.0 4.9 3 2 2 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 CDI79258.1 - 3.3e-05 24.1 2.3 3.9 8.1 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CDI79258.1 - 0.028 14.8 2.2 8.5 6.8 0.0 4.0 3 1 1 4 4 4 0 Ankyrin repeats (many copies) CPBP PF02517.16 CDI79259.1 - 2e-06 28.1 1.2 2e-06 28.1 1.2 4.3 5 1 0 5 5 5 2 CPBP intramembrane metalloprotease DUF2722 PF10846.8 CDI79259.1 - 1.1 8.1 0.0 1.1 8.1 0.0 5.7 5 1 0 5 5 5 0 Protein of unknown function (DUF2722) RskA PF10099.9 CDI79261.1 - 0.16 12.3 13.9 0.2 11.9 13.9 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA IHABP4_N PF16174.5 CDI79261.1 - 0.36 11.4 5.0 0.54 10.8 5.0 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal SPX PF03105.19 CDI79261.1 - 1.3 8.8 10.2 1.6 8.6 10.2 1.0 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI79261.1 - 4.7 5.9 10.3 5 5.9 10.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Myc_N PF01056.18 CDI79261.1 - 4.8 7.0 11.2 5.4 6.8 11.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Macoilin PF09726.9 CDI79262.1 - 0.021 13.4 18.4 0.029 12.9 18.4 1.1 1 0 0 1 1 1 0 Macoilin family PAP1 PF08601.10 CDI79262.1 - 0.3 10.8 19.7 0.4 10.4 19.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SPX PF03105.19 CDI79262.1 - 4.6 7.1 18.8 6 6.7 18.8 1.1 1 0 0 1 1 1 0 SPX domain Filament_head PF04732.14 CDI79263.1 - 0.051 14.4 29.1 0.1 13.5 29.1 1.5 1 0 0 1 1 1 0 Intermediate filament head (DNA binding) region RskA PF10099.9 CDI79263.1 - 0.12 12.7 36.2 0.16 12.2 27.3 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI79263.1 - 0.12 12.3 26.3 0.14 12.1 26.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI79263.1 - 0.12 10.9 18.9 0.17 10.4 18.9 1.2 1 0 0 1 1 1 0 Macoilin family Herpes_glycop PF01528.16 CDI79263.1 - 5.4 5.8 10.3 7.7 5.3 10.3 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Secretin_N_2 PF07655.13 CDI79263.1 - 6.7 7.3 26.6 0.095 13.3 18.2 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain SUIM_assoc PF16619.5 CDI79264.1 - 0.025 14.7 0.5 0.025 14.7 0.5 7.6 7 1 0 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 EF-hand_1 PF00036.32 CDI79266.1 - 3.1e-06 26.3 0.5 0.008 15.7 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDI79266.1 - 2.7e-05 23.7 1.3 0.075 13.0 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain DUF2722 PF10846.8 CDI79266.1 - 0.00016 20.8 34.6 0.00035 19.7 11.1 3.2 3 0 0 3 3 3 3 Protein of unknown function (DUF2722) EF-hand_8 PF13833.6 CDI79266.1 - 0.00033 20.5 0.1 0.012 15.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair Spt20 PF12090.8 CDI79266.1 - 0.00035 20.3 43.8 0.031 13.9 16.3 3.3 3 0 0 3 3 3 3 Spt20 family EF-hand_7 PF13499.6 CDI79266.1 - 0.0052 17.2 0.1 0.027 14.9 0.1 2.1 1 1 0 1 1 1 1 EF-hand domain pair DUF374 PF04028.13 CDI79266.1 - 0.01 15.4 0.3 0.041 13.4 0.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF374) ANAPC_CDC26 PF10471.9 CDI79266.1 - 0.029 15.2 11.2 0.029 15.2 11.2 4.7 3 1 0 3 3 2 0 Anaphase-promoting complex APC subunit CDC26 Suf PF05843.14 CDI79266.1 - 0.3 11.0 25.6 0.35 10.8 5.2 3.2 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI79266.1 - 0.45 10.5 15.1 0.94 9.5 4.6 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SPX PF03105.19 CDI79266.1 - 0.93 9.3 25.1 49 3.7 25.1 2.4 1 1 0 1 1 1 0 SPX domain Mlf1IP PF10248.9 CDI79266.1 - 1.2 9.0 9.9 0.35 10.8 3.5 2.8 3 0 0 3 3 3 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein DUF2052 PF09747.9 CDI79266.1 - 2.9 8.0 15.2 2.1 8.4 1.0 3.0 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Rpp20 PF12328.8 CDI79266.1 - 2.9 7.9 17.2 2 8.3 2.7 3.6 3 0 0 3 3 3 0 Rpp20 subunit of nuclear RNase MRP and P Macoilin PF09726.9 CDI79266.1 - 3.9 5.9 30.6 1.4 7.4 16.8 2.4 2 1 0 2 2 2 0 Macoilin family Thg1C PF14413.6 CDI79266.1 - 4 7.6 10.3 1.9 8.6 1.5 3.0 3 0 0 3 3 3 0 Thg1 C terminal domain DUF979 PF06166.12 CDI79266.1 - 5.3 6.1 5.8 0.73 8.9 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF979) F-protein PF00469.20 CDI79266.1 - 8.9 5.8 10.2 7.2 6.1 0.5 2.9 3 0 0 3 3 3 0 Negative factor, (F-Protein) or Nef Glyco_hydro_19 PF00182.19 CDI79267.1 - 2.8e-08 34.0 0.0 4.7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Chitinase class I DUF2722 PF10846.8 CDI79267.1 - 2 7.3 12.1 3 6.7 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI79267.1 - 2.3 7.8 15.3 3.9 7.0 15.3 1.3 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 CDI79267.1 - 2.3 6.8 3.9 3 6.4 3.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 CDI79267.1 - 7 6.5 14.0 0.69 9.8 9.1 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PFU PF09070.11 CDI79268.1 - 1.7e-11 44.4 3.2 2e-11 44.1 0.1 2.6 2 1 0 2 2 2 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 CDI79268.1 - 8.1e-10 38.4 1.0 8.1e-10 38.4 1.0 3.3 3 1 1 4 4 4 2 PUL domain WD40 PF00400.32 CDI79268.1 - 4.6e-05 24.1 10.7 3 8.9 0.1 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF5327 PF17261.2 CDI79268.1 - 1.8 9.4 15.1 3 8.7 4.1 3.1 2 0 0 2 2 2 0 Family of unknown function (DUF5327) SR-25 PF10500.9 CDI79268.1 - 3.8 7.1 26.1 0.52 9.9 3.1 3.7 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein MitMem_reg PF13012.6 CDI79271.1 - 0.0044 17.4 0.2 0.025 15.0 0.0 2.3 2 1 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CDI79271.1 - 0.0048 16.9 1.3 0.007 16.3 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SdpA PF17418.2 CDI79271.1 - 0.073 12.9 3.9 1.5 8.7 3.5 2.5 2 0 0 2 2 2 0 Sporulation delaying protein SdpA Hydant_A_N PF05378.13 CDI79276.1 - 0.0071 16.1 1.9 0.038 13.7 0.3 2.1 1 1 1 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Tme5_EGF_like PF09064.10 CDI79279.1 - 0.12 12.3 0.8 0.25 11.2 0.8 1.5 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like ANAPC_CDC26 PF10471.9 CDI79279.1 - 2.3 9.1 9.3 6.7 7.6 5.2 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 RskA PF10099.9 CDI79280.1 - 0.01 16.1 17.0 0.01 16.1 17.0 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Ant_C PF05586.11 CDI79280.1 - 0.092 13.4 0.3 0.16 12.6 0.3 1.4 1 0 0 1 1 1 0 Anthrax receptor C-terminus region TFIIA PF03153.13 CDI79280.1 - 0.096 12.7 17.5 0.12 12.4 17.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_Rpc4 PF05132.14 CDI79280.1 - 2.6 8.5 12.5 2.2 8.7 1.3 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 Pkinase_Tyr PF07714.17 CDI79281.1 - 4.2e-32 111.5 0.0 2.8e-30 105.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDI79281.1 - 5.7e-32 111.1 0.0 1.3e-30 106.6 0.0 3.1 3 2 0 3 3 3 1 Protein kinase domain Activator_LAG-3 PF11498.8 CDI79281.1 - 0.004 16.2 0.1 0.004 16.2 0.1 4.6 4 0 0 4 4 4 1 Transcriptional activator LAG-3 Pkinase_fungal PF17667.1 CDI79281.1 - 0.022 13.5 0.0 0.022 13.5 0.0 4.7 6 1 0 6 6 6 0 Fungal protein kinase RAP PF08373.10 CDI79282.1 - 1.4e-12 47.5 0.0 3.7e-12 46.1 0.0 1.8 1 0 0 1 1 1 1 RAP domain CNDH2_C PF16858.5 CDI79282.1 - 0.0051 16.7 25.1 0.016 15.1 2.4 2.2 2 0 0 2 2 2 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term FAST_1 PF06743.15 CDI79282.1 - 0.01 15.7 1.0 22 5.1 0.0 4.0 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 SID-1_RNA_chan PF13965.6 CDI79282.1 - 0.034 12.6 7.9 0.72 8.2 2.3 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 TFIIA PF03153.13 CDI79282.1 - 0.035 14.1 66.1 0.028 14.4 29.4 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF913 PF06025.12 CDI79282.1 - 0.041 12.9 17.0 0.033 13.2 4.9 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 CDI79282.1 - 0.11 12.6 22.5 0.084 12.9 6.7 2.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDI79282.1 - 0.11 12.3 32.1 0.041 13.7 10.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TT_ORF1 PF02956.14 CDI79282.1 - 0.21 10.2 13.3 0.34 9.5 2.1 2.1 2 0 0 2 2 2 0 TT viral orf 1 Velvet PF11754.8 CDI79282.1 - 0.21 11.5 18.9 0.22 11.4 4.7 2.5 2 0 0 2 2 2 0 Velvet factor RNA_pol_Rpc4 PF05132.14 CDI79282.1 - 0.22 12.0 21.3 0.034 14.6 3.3 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 Presenilin PF01080.17 CDI79282.1 - 0.22 10.3 34.7 0.81 8.4 9.6 2.3 2 0 0 2 2 2 0 Presenilin HAUS6_N PF14661.6 CDI79282.1 - 0.32 10.5 34.4 0.96 9.0 9.8 2.4 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus CCDC53 PF10152.9 CDI79282.1 - 0.35 11.3 24.7 0.084 13.3 2.5 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Connexin PF00029.19 CDI79282.1 - 1.6 8.4 29.1 0.25 11.1 6.0 2.4 2 0 0 2 2 2 0 Connexin NARP1 PF12569.8 CDI79282.1 - 1.7 7.5 31.1 0.062 12.2 10.1 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Rtf2 PF04641.12 CDI79282.1 - 2.1 7.7 23.2 0.11 11.8 0.4 2.5 2 0 0 2 2 2 0 Rtf2 RING-finger Serinc PF03348.15 CDI79282.1 - 3.9 6.3 19.5 0.19 10.6 0.9 2.4 2 0 0 2 2 2 0 Serine incorporator (Serinc) TCP PF03634.13 CDI79282.1 - 4.3 7.9 31.5 2.1 8.9 7.4 3.0 3 0 0 3 3 3 0 TCP family transcription factor Cwf_Cwc_15 PF04889.12 CDI79282.1 - 4.6 6.9 33.4 0.25 11.1 12.3 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein OATP PF03137.20 CDI79282.1 - 6.1 5.0 14.4 0.16 10.2 0.1 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2464 PF10240.9 CDI79282.1 - 8.3 5.9 15.1 1.7 8.2 4.6 2.2 2 0 0 2 2 2 0 Multivesicular body subunit 12 PPL5 PF18168.1 CDI79282.1 - 8.8 5.5 21.6 4 6.6 5.3 2.3 2 0 0 2 2 2 0 Prim-pol family 5 Vfa1 PF08432.10 CDI79282.1 - 9.3 6.5 34.7 0.86 9.9 11.3 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Zip PF02535.22 CDI79282.1 - 9.9 5.3 16.6 0.3 10.3 1.4 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2989 PF11207.8 CDI79283.1 - 0.023 14.5 0.1 0.046 13.5 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2989) Cnl2_NKP2 PF09447.10 CDI79283.1 - 0.11 12.7 0.5 0.35 11.1 0.3 1.9 2 0 0 2 2 2 0 Cnl2/NKP2 family protein TPR_6 PF13174.6 CDI79284.1 - 0.0024 18.4 0.1 6.7 7.6 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat Mitofilin PF09731.9 CDI79284.1 - 0.0045 15.9 30.4 0.0063 15.4 30.4 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Shadoo PF14999.6 CDI79284.1 - 0.065 13.3 11.9 0.74 9.9 5.5 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective ABC2_membrane_2 PF12679.7 CDI79284.1 - 0.15 11.3 3.8 0.24 10.6 3.8 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF966 PF06136.13 CDI79284.1 - 0.16 11.7 31.3 0.13 11.9 27.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF966) SAPS PF04499.15 CDI79284.1 - 1 8.0 14.3 1.6 7.4 14.3 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PAT1 PF09770.9 CDI79284.1 - 1.7 6.8 32.0 2.3 6.4 32.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAP65_ASE1 PF03999.12 CDI79284.1 - 2.5 6.7 30.1 2.2 6.9 26.4 1.9 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) DUF4647 PF15504.6 CDI79284.1 - 4.8 6.2 24.9 7 5.6 24.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) DUF4746 PF15928.5 CDI79284.1 - 7.7 5.8 14.4 11 5.4 14.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FemAB PF02388.16 CDI79284.1 - 9.3 5.0 18.4 12 4.6 18.4 1.1 1 0 0 1 1 1 0 FemAB family Macoilin PF09726.9 CDI79284.1 - 9.3 4.7 32.4 6.5 5.2 27.9 2.1 2 0 0 2 2 2 0 Macoilin family Alg14 PF08660.11 CDI79286.1 - 9e-10 38.8 0.2 9e-10 38.8 0.2 3.3 3 1 1 4 4 2 1 Oligosaccharide biosynthesis protein Alg14 like Otopetrin PF03189.13 CDI79286.1 - 2e-06 26.9 4.1 2e-06 26.9 4.1 2.5 1 1 1 2 2 1 1 Otopetrin Presenilin PF01080.17 CDI79286.1 - 0.00035 19.5 0.9 0.00035 19.5 0.9 3.6 2 1 0 2 2 1 1 Presenilin IF3_N PF05198.16 CDI79286.1 - 0.00048 20.3 0.8 0.0022 18.2 0.0 2.7 2 1 0 2 2 1 1 Translation initiation factor IF-3, N-terminal domain Peroxin-13_N PF04088.13 CDI79286.1 - 0.00058 20.1 2.9 0.00058 20.1 2.9 4.8 4 1 0 4 4 3 1 Peroxin 13, N-terminal region CDC45 PF02724.14 CDI79286.1 - 0.00068 18.1 13.9 0.00068 18.1 13.9 3.0 3 0 0 3 3 3 1 CDC45-like protein CSG2 PF16965.5 CDI79286.1 - 0.00085 18.4 1.0 0.00085 18.4 1.0 3.8 3 1 1 4 4 4 1 Ceramide synthase regulator SpoIIP PF07454.11 CDI79286.1 - 0.0012 18.4 49.3 0.018 14.5 13.9 4.1 4 0 0 4 4 4 2 Stage II sporulation protein P (SpoIIP) Afi1 PF07792.12 CDI79286.1 - 0.0026 18.2 43.0 0.13 12.7 11.4 4.2 4 0 0 4 4 4 2 Docking domain of Afi1 for Arf3 in vesicle trafficking OATP PF03137.20 CDI79286.1 - 0.003 15.9 2.6 0.003 15.9 2.6 3.9 3 1 0 3 3 2 1 Organic Anion Transporter Polypeptide (OATP) family Eapp_C PF10238.9 CDI79286.1 - 0.0062 16.6 4.3 0.0062 16.6 4.3 4.7 4 1 0 4 4 3 1 E2F-associated phosphoprotein Connexin PF00029.19 CDI79286.1 - 0.0074 16.1 2.2 0.0074 16.1 2.2 4.1 3 1 0 4 4 4 1 Connexin Pox_Ag35 PF03286.14 CDI79286.1 - 0.0085 15.9 9.1 0.0085 15.9 9.1 3.7 4 0 0 4 4 4 1 Pox virus Ag35 surface protein GET2 PF08690.10 CDI79286.1 - 0.0091 15.7 6.6 0.0091 15.7 6.6 3.8 2 1 0 3 3 2 1 GET complex subunit GET2 NPR3 PF03666.13 CDI79286.1 - 0.0098 14.7 6.4 0.0098 14.7 6.4 3.9 3 1 0 3 3 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Gti1_Pac2 PF09729.9 CDI79286.1 - 0.011 15.9 9.6 0.011 15.9 9.6 3.5 3 1 0 3 3 2 0 Gti1/Pac2 family TCP PF03634.13 CDI79286.1 - 0.012 16.2 48.0 0.13 12.8 11.3 4.1 4 0 0 4 4 4 0 TCP family transcription factor MDM10 PF12519.8 CDI79286.1 - 0.013 14.3 0.8 0.013 14.3 0.8 3.3 3 1 0 3 3 2 0 Mitochondrial distribution and morphology protein 10 DUF5308 PF17233.2 CDI79286.1 - 0.019 15.2 0.8 0.019 15.2 0.8 4.5 2 1 0 2 2 1 0 Family of unknown function (DUF5308) DUF4471 PF14740.6 CDI79286.1 - 0.023 13.9 0.7 0.023 13.9 0.7 4.1 3 1 0 4 4 4 0 Domain of unknown function (DUF4471) SDA1 PF05285.12 CDI79286.1 - 0.036 13.5 45.5 0.024 14.1 7.6 3.1 3 0 0 3 3 3 0 SDA1 Renin_r PF07850.14 CDI79286.1 - 0.063 13.9 0.8 0.063 13.9 0.8 4.9 4 1 0 4 4 3 0 Renin receptor-like protein PIP5K PF01504.18 CDI79286.1 - 0.082 12.1 42.9 0.028 13.7 1.5 3.1 3 0 0 3 3 3 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4228 PF14009.6 CDI79286.1 - 0.12 12.8 0.1 0.12 12.8 0.1 4.1 2 1 0 2 2 1 0 Domain of unknown function (DUF4228) EFTUD2 PF16004.5 CDI79286.1 - 0.17 12.5 52.2 0.27 11.8 9.4 4.3 4 0 0 4 4 4 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF5523 PF17661.1 CDI79286.1 - 0.61 9.7 51.5 0.26 11.0 14.6 4.1 4 0 0 4 4 4 0 Family of unknown function (DUF5523) SARAF PF06682.12 CDI79286.1 - 0.7 9.5 42.3 1.4 8.5 0.0 4.1 2 1 1 4 4 3 0 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S64 PF08192.11 CDI79286.1 - 0.77 8.2 46.3 0.057 11.9 24.4 3.0 3 0 0 3 3 3 0 Peptidase family S64 DUF4366 PF14283.6 CDI79286.1 - 0.84 9.7 33.0 0.42 10.6 1.2 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4366) LAP1C PF05609.12 CDI79286.1 - 1.3 8.0 54.2 0.083 12.0 4.2 3.1 3 0 0 3 3 3 0 Lamina-associated polypeptide 1C (LAP1C) Ureide_permease PF07168.11 CDI79286.1 - 1.6 7.4 27.8 0.048 12.4 1.4 3.7 4 0 0 4 4 4 0 Ureide permease dsRBD2 PF17842.1 CDI79286.1 - 1.7 8.8 31.7 0.35 11.1 4.2 4.5 4 0 0 4 4 4 0 Double-stranded RNA binding domain 2 Senescence_reg PF04520.13 CDI79286.1 - 1.9 9.3 42.5 0.31 11.9 9.4 3.2 3 0 0 3 3 3 0 Senescence regulator PTPRCAP PF15713.5 CDI79286.1 - 1.9 8.7 59.3 0.31 11.3 19.9 4.2 4 0 0 4 4 4 0 Protein tyrosine phosphatase receptor type C-associated Tim54 PF11711.8 CDI79286.1 - 2.5 6.8 48.4 1.4 7.7 15.7 4.0 4 0 0 4 4 4 0 Inner membrane protein import complex subunit Tim54 DUF2370 PF10176.9 CDI79286.1 - 3.1 7.4 28.1 0.058 13.0 0.7 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2370) RNA_pol_Rpc4 PF05132.14 CDI79286.1 - 3.8 7.9 47.7 0.069 13.6 12.8 4.3 4 0 0 4 4 4 0 RNA polymerase III RPC4 Peptidase_S49_N PF08496.10 CDI79286.1 - 5.2 7.1 63.8 0.48 10.5 2.4 4.7 4 1 0 4 4 3 0 Peptidase family S49 N-terminal PCI PF01399.27 CDI79287.1 - 5.1e-12 46.2 0.2 9.2e-12 45.4 0.2 1.4 1 0 0 1 1 1 1 PCI domain Paf67 PF10255.9 CDI79287.1 - 0.034 13.2 1.2 0.042 12.8 1.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 SAPS PF04499.15 CDI79288.1 - 0.00024 20.1 11.8 0.00024 20.1 11.8 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein CDC45 PF02724.14 CDI79288.1 - 0.00028 19.3 18.3 0.00031 19.2 18.3 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF4746 PF15928.5 CDI79288.1 - 0.00033 20.2 10.1 0.00043 19.8 10.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI79288.1 - 0.0014 17.4 31.0 0.0018 17.1 31.0 1.1 1 0 0 1 1 1 1 Presenilin CLN3 PF02487.17 CDI79288.1 - 0.0034 16.5 12.6 0.0045 16.1 12.6 1.4 1 0 0 1 1 1 1 CLN3 protein DUF572 PF04502.13 CDI79288.1 - 0.0051 16.5 19.1 0.0059 16.3 19.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Zip PF02535.22 CDI79288.1 - 0.0082 15.4 10.5 0.01 15.1 10.5 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Dsh_C PF12316.8 CDI79288.1 - 0.0085 16.5 10.9 0.011 16.2 10.9 1.1 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal VIR_N PF15912.5 CDI79288.1 - 0.012 15.3 13.4 0.013 15.1 13.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal SID-1_RNA_chan PF13965.6 CDI79288.1 - 0.014 13.9 6.9 0.016 13.7 6.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CAC1F_C PF16885.5 CDI79288.1 - 0.015 15.0 17.0 0.018 14.7 17.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Exonuc_VII_L PF02601.15 CDI79288.1 - 0.016 14.8 19.3 0.017 14.7 19.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Dynactin_p62 PF05502.13 CDI79288.1 - 0.027 13.3 15.2 0.038 12.8 15.2 1.3 1 0 0 1 1 1 0 Dynactin p62 family FAM60A PF15396.6 CDI79288.1 - 0.027 14.5 21.0 0.034 14.1 21.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4661 PF15576.6 CDI79288.1 - 0.042 13.8 4.7 0.058 13.3 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) LMBR1 PF04791.16 CDI79288.1 - 0.043 12.7 10.7 0.044 12.7 10.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RR_TM4-6 PF06459.12 CDI79288.1 - 0.057 13.2 31.6 0.072 12.9 31.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pannexin_like PF12534.8 CDI79288.1 - 0.072 12.2 18.5 0.09 11.9 18.5 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF4569 PF15133.6 CDI79288.1 - 0.075 12.8 23.4 0.087 12.5 23.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Velvet PF11754.8 CDI79288.1 - 0.083 12.8 24.4 0.11 12.4 24.4 1.2 1 0 0 1 1 1 0 Velvet factor CCSAP PF15748.5 CDI79288.1 - 0.097 12.8 31.8 0.12 12.5 31.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Gti1_Pac2 PF09729.9 CDI79288.1 - 0.099 12.7 25.2 0.13 12.3 25.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Raftlin PF15250.6 CDI79288.1 - 0.13 11.0 21.5 0.15 10.8 21.5 1.0 1 0 0 1 1 1 0 Raftlin DUF4045 PF13254.6 CDI79288.1 - 0.16 11.6 25.0 0.2 11.3 25.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Pkinase_fungal PF17667.1 CDI79288.1 - 0.18 10.5 14.1 0.21 10.3 14.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF913 PF06025.12 CDI79288.1 - 0.19 10.7 17.2 0.25 10.3 17.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PAT1 PF09770.9 CDI79288.1 - 0.22 9.8 44.0 0.25 9.6 44.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2828 PF11443.8 CDI79288.1 - 0.26 9.3 28.3 0.34 8.9 28.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GAGA_bind PF06217.12 CDI79288.1 - 0.33 11.2 22.3 0.4 10.9 22.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4192 PF13830.6 CDI79288.1 - 0.37 10.8 7.0 0.49 10.4 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) SLC12 PF03522.15 CDI79288.1 - 0.43 9.5 31.0 0.53 9.3 31.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Med19 PF10278.9 CDI79288.1 - 0.48 10.3 17.2 0.58 10.1 17.2 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 BORG_CEP PF14957.6 CDI79288.1 - 0.49 11.6 18.4 0.69 11.1 18.4 1.3 1 0 0 1 1 1 0 Cdc42 effector Hamartin PF04388.12 CDI79288.1 - 0.52 8.9 27.0 0.62 8.7 27.0 1.0 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 CDI79288.1 - 0.58 9.2 27.9 0.69 8.9 27.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PA26 PF04636.13 CDI79288.1 - 0.74 8.7 20.8 0.88 8.4 20.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FapA PF03961.13 CDI79288.1 - 0.78 8.3 17.1 0.88 8.1 17.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ALMT PF11744.8 CDI79288.1 - 0.89 8.3 23.6 1.1 8.0 23.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Nop53 PF07767.11 CDI79288.1 - 0.93 8.8 38.8 1.1 8.5 38.8 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Ndc1_Nup PF09531.10 CDI79288.1 - 0.95 8.1 22.3 1.1 7.8 22.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Calici_coat_C PF08435.11 CDI79288.1 - 1.3 8.5 16.6 1.7 8.1 16.6 1.1 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal Cdh1_DBD_1 PF18196.1 CDI79288.1 - 1.3 9.3 15.9 2.3 8.6 15.9 1.4 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Neur_chan_memb PF02932.16 CDI79288.1 - 1.4 8.9 22.7 1.8 8.5 22.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Smg8_Smg9 PF10220.9 CDI79288.1 - 1.5 7.1 26.6 1.7 6.9 26.6 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF853 PF05872.12 CDI79288.1 - 1.5 7.3 17.1 2.2 6.8 17.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AF-4 PF05110.13 CDI79288.1 - 1.5 6.8 32.0 1.8 6.6 32.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDK5_activator PF03261.15 CDI79288.1 - 1.5 8.3 20.8 1.8 8.0 20.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF789 PF05623.12 CDI79288.1 - 1.6 8.4 19.3 2.1 8.0 19.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Membralin PF09746.9 CDI79288.1 - 1.6 7.6 18.6 2 7.4 18.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF1387 PF07139.11 CDI79288.1 - 1.7 8.3 29.1 2.1 8.0 29.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PTPlike_phytase PF14566.6 CDI79288.1 - 1.8 8.7 16.4 2.4 8.2 16.4 1.1 1 0 0 1 1 1 0 Inositol hexakisphosphate MMR1 PF08505.10 CDI79288.1 - 1.8 8.8 34.8 2.5 8.3 34.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI79288.1 - 1.8 8.0 34.9 2.2 7.7 34.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF908 PF06012.12 CDI79288.1 - 1.9 7.8 21.4 2.4 7.5 21.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CSG2 PF16965.5 CDI79288.1 - 1.9 7.3 15.2 3 6.7 15.2 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2151 PF10221.9 CDI79288.1 - 2.2 6.8 17.4 2.6 6.5 17.4 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator GREB1 PF15782.5 CDI79288.1 - 2.4 5.2 29.3 2.8 5.0 29.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MCM_bind PF09739.9 CDI79288.1 - 2.4 6.5 27.5 2.9 6.2 27.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF5524 PF17662.1 CDI79288.1 - 2.6 7.3 19.6 3.4 6.9 19.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5524) Dapper PF15268.6 CDI79288.1 - 2.7 6.7 31.8 3.2 6.5 31.8 1.0 1 0 0 1 1 1 0 Dapper Glyco_transf_41 PF13844.6 CDI79288.1 - 3.1 6.1 16.0 3.7 5.9 16.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 AAA_11 PF13086.6 CDI79288.1 - 3.2 7.5 28.1 3.9 7.2 28.1 1.1 1 0 0 1 1 1 0 AAA domain Vfa1 PF08432.10 CDI79288.1 - 3.2 8.0 32.9 4.4 7.6 32.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4228 PF14009.6 CDI79288.1 - 3.3 8.1 15.1 5.2 7.4 15.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF2981 PF11200.8 CDI79288.1 - 3.6 7.2 10.9 4.5 6.9 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF4337 PF14235.6 CDI79288.1 - 3.6 7.7 25.0 4.8 7.3 25.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Cellulose_synt PF03552.14 CDI79288.1 - 4 5.8 12.4 4.6 5.6 12.4 1.1 1 0 0 1 1 1 0 Cellulose synthase Rtf2 PF04641.12 CDI79288.1 - 4.4 6.6 28.4 5.5 6.3 28.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger NEMP PF10225.9 CDI79288.1 - 4.4 6.9 9.3 5.3 6.6 9.3 1.2 1 0 0 1 1 1 0 NEMP family PPL5 PF18168.1 CDI79288.1 - 4.5 6.5 21.5 6.9 5.9 21.5 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Hid1 PF12722.7 CDI79288.1 - 4.6 5.3 30.0 5.5 5.0 30.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Auxin_canalis PF05703.11 CDI79288.1 - 4.6 7.1 13.7 5.8 6.8 13.7 1.2 1 0 0 1 1 1 0 Auxin canalisation DUF3295 PF11702.8 CDI79288.1 - 6 6.1 30.6 7.6 5.8 30.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) NPR3 PF03666.13 CDI79288.1 - 6.7 5.4 32.0 8.5 5.0 32.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 tRNA-synt_2c PF01411.19 CDI79288.1 - 6.8 5.1 18.2 9.3 4.6 18.2 1.1 1 0 0 1 1 1 0 tRNA synthetases class II (A) ASC PF00858.24 CDI79288.1 - 6.8 5.5 18.1 7.9 5.3 18.1 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel GBP_C PF02841.14 CDI79288.1 - 7.3 5.9 42.0 10 5.4 42.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF5427 PF10310.9 CDI79288.1 - 7.6 5.4 36.3 10 4.9 36.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) eIF-3_zeta PF05091.12 CDI79288.1 - 7.8 5.3 39.4 11 4.8 39.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Asp-B-Hydro_N PF05279.11 CDI79288.1 - 7.9 6.5 24.7 10 6.1 24.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Otopetrin PF03189.13 CDI79288.1 - 7.9 5.2 18.7 9.4 4.9 18.7 1.1 1 0 0 1 1 1 0 Otopetrin Caldesmon PF02029.15 CDI79288.1 - 8 5.1 34.2 10 4.8 34.2 1.0 1 0 0 1 1 1 0 Caldesmon RskA PF10099.9 CDI79288.1 - 8.4 6.6 24.5 5e+03 -2.4 24.5 2.2 1 1 0 1 1 0 0 Anti-sigma-K factor rskA BPL_N PF09825.9 CDI79288.1 - 8.5 5.3 16.3 12 4.9 16.3 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Podoplanin PF05808.11 CDI79288.1 - 9.5 6.3 7.4 16 5.6 7.4 1.4 1 0 0 1 1 1 0 Podoplanin REPA_OB_2 PF16900.5 CDI79289.1 - 1.1e-09 38.1 0.0 2.4e-07 30.6 0.1 2.6 2 1 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 CDI79289.1 - 0.0012 18.8 0.0 0.13 12.3 0.0 2.6 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain TFIIA PF03153.13 CDI79289.1 - 0.0049 16.9 9.7 0.0058 16.7 9.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI79289.1 - 0.01 15.5 9.0 0.014 15.0 9.0 1.2 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI79289.1 - 0.058 12.3 7.5 0.077 11.9 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) AAA_23 PF13476.6 CDI79289.1 - 0.23 11.9 3.5 0.34 11.4 3.5 1.2 1 0 0 1 1 1 0 AAA domain Activator_LAG-3 PF11498.8 CDI79289.1 - 2.7 6.9 21.0 3.8 6.4 21.0 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 IMP2_N PF18590.1 CDI79290.1 - 9.8e-27 93.3 0.1 1.5e-26 92.7 0.1 1.3 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain IMP2_C PF18591.1 CDI79290.1 - 0.021 14.7 0.2 0.051 13.5 0.2 1.7 1 0 0 1 1 1 0 Immune Mapped Protein 2 (IMP2) C-terminal domain Biotin_lipoyl PF00364.22 CDI79291.1 - 1.2e-19 69.9 0.6 1.7e-19 69.4 0.6 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme S36_mt PF10937.8 CDI79291.1 - 7.5e-06 27.5 1.6 7.5e-06 27.5 1.6 3.6 3 2 0 3 3 3 1 Ribosomal protein S36, mitochondrial Biotin_lipoyl_2 PF13533.6 CDI79291.1 - 0.083 12.7 7.0 0.75 9.7 0.0 2.9 2 1 1 3 3 3 0 Biotin-lipoyl like tRNA-synt_1b PF00579.25 CDI79295.1 - 7.9e-33 114.0 0.2 7.6e-32 110.8 0.2 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) DASH_Dam1 PF08653.10 CDI79295.1 - 0.036 13.9 0.0 0.076 12.8 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Dam1 DEAD PF00270.29 CDI79296.1 - 1.2e-40 139.1 0.0 1.2e-40 139.1 0.0 2.9 3 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79296.1 - 9.8e-06 25.9 0.3 2.3e-05 24.7 0.3 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI79296.1 - 8.4e-05 22.6 0.9 0.012 15.6 0.0 3.4 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit SR-25 PF10500.9 CDI79296.1 - 0.038 13.6 12.1 0.35 10.4 2.9 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CMS1 PF14617.6 CDI79296.1 - 0.32 10.3 0.0 0.32 10.3 0.0 1.6 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF4228 PF14009.6 CDI79296.1 - 1.1 9.6 14.0 3 8.2 10.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) PAT1 PF09770.9 CDI79296.1 - 4.3 5.5 21.3 0.31 9.3 15.4 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Ephrin_rec_like PF07699.13 CDI79297.1 - 7.2e-11 41.7 358.9 2.6e-05 23.9 3.8 32.6 20 11 7 29 29 29 22 Putative ephrin-receptor like Metal_CEHH PF14455.6 CDI79299.1 - 0.14 11.7 0.1 0.36 10.4 0.1 1.6 1 0 0 1 1 1 0 Predicted metal binding domain DUF4986 PF16375.5 CDI79299.1 - 0.14 12.8 0.7 4 8.2 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function cNMP_binding PF00027.29 CDI79300.1 - 1.3e-11 44.4 0.0 1.9e-06 27.8 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Eryth_link_C PF16915.5 CDI79300.1 - 0.062 13.3 0.1 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Annelid erythrocruorin linker subunit C-terminus SUIM_assoc PF16619.5 CDI79301.1 - 0.0028 17.7 47.4 0.018 15.1 0.0 6.7 3 3 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Connexin PF00029.19 CDI79301.1 - 0.15 11.8 12.8 0.16 11.7 3.5 2.5 2 0 0 2 2 2 0 Connexin PepSY_TM_like_2 PF16357.5 CDI79301.1 - 0.16 12.0 1.3 0.49 10.3 1.3 1.8 1 0 0 1 1 1 0 Putative PepSY_TM-like Dpy-30 PF05186.13 CDI79301.1 - 0.51 10.1 0.1 0.51 10.1 0.1 3.1 4 0 0 4 4 4 0 Dpy-30 motif FHIPEP PF00771.20 CDI79301.1 - 2.4 6.5 8.7 0.22 9.9 1.2 2.3 2 0 0 2 2 2 0 FHIPEP family DUF1980 PF09323.10 CDI79301.1 - 4.9 7.0 11.6 7.6 6.4 3.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) DUF4471 PF14740.6 CDI79301.1 - 7.1 5.7 11.9 1.1 8.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) AIF_C PF14721.6 CDI79301.1 - 7.9 6.9 17.9 8.1 6.8 7.0 3.5 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CLN3 PF02487.17 CDI79301.1 - 8.2 5.4 12.2 1.4 7.9 3.8 2.3 2 0 0 2 2 2 0 CLN3 protein IMUP PF15761.5 CDI79303.1 - 5.9 7.6 16.1 6.2 7.6 14.5 1.8 1 1 1 2 2 2 0 Immortalisation up-regulated protein ANAPC1 PF12859.7 CDI79303.1 - 6.5 7.3 11.7 0.67 10.5 2.7 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 1 KHA PF11834.8 CDI79304.1 - 0.12 12.5 1.8 0.81 9.8 0.1 2.5 2 1 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel Proteasome PF00227.26 CDI79305.1 - 1.4e-45 155.2 0.2 2.3e-45 154.4 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit zf-C2H2_jaz PF12171.8 CDI79307.1 - 8.8e-05 22.7 1.4 0.00015 22.0 1.4 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDI79307.1 - 0.00014 22.2 1.8 0.00023 21.4 1.8 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 CDI79307.1 - 0.32 10.8 0.9 0.64 9.8 0.9 1.4 1 0 0 1 1 1 0 U1 zinc finger AP2 PF00847.20 CDI79311.1 - 0.00017 21.7 0.0 0.00017 21.7 0.0 2.9 2 0 0 2 2 2 1 AP2 domain RskA PF10099.9 CDI79311.1 - 0.0012 19.1 1.3 0.0012 19.1 1.3 11.3 2 2 3 8 8 8 3 Anti-sigma-K factor rskA zf-rbx1 PF12678.7 CDI79313.1 - 2.8e-07 30.7 2.5 5e-07 29.9 2.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDI79313.1 - 3.2e-07 30.6 2.0 4.3e-07 30.2 2.0 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDI79313.1 - 1.7e-05 24.6 1.6 2.6e-05 24.0 1.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI79313.1 - 7.5e-05 22.5 2.1 0.00011 21.9 2.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDI79313.1 - 0.00039 20.0 1.4 0.00058 19.4 1.4 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDI79313.1 - 0.0011 18.9 0.4 0.0017 18.4 0.4 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Ribosomal_60s PF00428.19 CDI79313.1 - 0.0018 18.8 0.6 0.0018 18.8 0.6 3.1 1 1 2 3 3 1 1 60s Acidic ribosomal protein zf-RING_UBOX PF13445.6 CDI79313.1 - 0.0029 17.6 0.7 0.0049 16.9 0.7 1.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 CDI79313.1 - 0.0032 17.2 0.2 0.0052 16.5 0.2 1.4 1 0 0 1 1 1 1 RING-like zinc finger FANCL_C PF11793.8 CDI79313.1 - 0.02 15.1 4.7 0.18 12.0 4.7 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Sgf11 PF08209.11 CDI79313.1 - 0.021 14.4 0.1 0.035 13.7 0.1 1.4 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) zf-RING_5 PF14634.6 CDI79313.1 - 0.045 13.7 1.2 0.066 13.2 1.2 1.2 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING-like PF08746.11 CDI79313.1 - 0.061 13.6 2.4 0.092 13.1 2.4 1.2 1 0 0 1 1 1 0 RING-like domain DUF116 PF01976.17 CDI79313.1 - 0.07 12.6 0.1 0.084 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF116 zf-C3HC4_3 PF13920.6 CDI79313.1 - 0.1 12.5 0.4 0.14 12.0 0.4 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CDI79313.1 - 0.28 11.3 2.0 0.48 10.6 2.0 1.3 1 0 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 CDI79313.1 - 0.49 10.5 3.1 1.1 9.4 3.1 1.5 1 1 0 1 1 1 0 Zinc-finger EMC3_TMCO1 PF01956.16 CDI79316.1 - 0.66 9.7 2.9 2 8.1 2.9 1.8 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Tmemb_9 PF05434.11 CDI79316.1 - 2 8.3 7.5 3.1 7.7 0.0 2.6 2 0 0 2 2 2 0 TMEM9 V_ATPase_I PF01496.19 CDI79316.1 - 2.6 5.9 6.7 4.4 5.1 6.7 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 CDI79316.1 - 3 7.3 14.9 5.9 6.4 14.9 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hamartin PF04388.12 CDI79316.1 - 5.2 5.6 18.8 6.8 5.2 18.8 1.2 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 CDI79316.1 - 8.4 4.9 18.0 0.74 8.4 13.3 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup EF-hand_8 PF13833.6 CDI79317.1 - 0.00039 20.2 0.1 0.00092 19.0 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 CDI79317.1 - 0.00058 19.2 0.2 0.0014 18.0 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDI79317.1 - 0.0017 18.8 0.8 0.0024 18.3 0.3 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CDI79317.1 - 0.0021 17.5 0.5 0.0053 16.2 0.5 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDI79317.1 - 0.021 14.7 0.2 0.16 12.0 0.2 2.4 2 0 0 2 2 2 0 EF-hand domain TPR_7 PF13176.6 CDI79318.1 - 0.046 13.8 0.8 0.49 10.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat HicB PF05534.12 CDI79318.1 - 0.19 11.6 0.3 0.19 11.6 0.3 2.2 2 0 0 2 2 2 0 HicB family UPF0565 PF10561.9 CDI79319.1 - 0.48 9.6 18.0 0.54 9.4 18.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 NPR3 PF03666.13 CDI79319.1 - 0.62 8.8 19.8 0.71 8.6 19.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 CDI79319.1 - 0.62 9.4 31.1 0.69 9.3 31.1 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 CDI79319.1 - 0.68 9.1 10.5 0.74 9.0 10.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1168 PF06658.12 CDI79319.1 - 0.72 9.7 25.9 0.9 9.4 25.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Scs3p PF10261.9 CDI79319.1 - 0.75 9.2 9.6 1 8.8 9.6 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2052 PF09747.9 CDI79319.1 - 1 9.4 23.2 1.2 9.2 23.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 CDI79319.1 - 1.3 8.8 22.6 1.4 8.6 22.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI79319.1 - 1.4 7.8 18.3 1.5 7.8 18.3 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2828 PF11443.8 CDI79319.1 - 1.6 6.8 23.1 1.8 6.6 23.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Rtf2 PF04641.12 CDI79319.1 - 1.8 7.8 19.8 2 7.7 19.8 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Afi1 PF07792.12 CDI79319.1 - 1.9 9.0 19.9 2.2 8.8 19.9 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CCDC53 PF10152.9 CDI79319.1 - 2.2 8.7 21.1 2.7 8.4 21.1 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PDCD7 PF16021.5 CDI79319.1 - 3.1 6.8 30.5 3.3 6.8 30.5 1.0 1 0 0 1 1 1 0 Programmed cell death protein 7 DUF4746 PF15928.5 CDI79319.1 - 3.3 7.1 19.6 3.9 6.8 19.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Velvet PF11754.8 CDI79319.1 - 3.4 7.5 20.8 3.7 7.4 20.8 1.0 1 0 0 1 1 1 0 Velvet factor Connexin PF00029.19 CDI79319.1 - 3.6 7.3 17.5 5 6.8 17.5 1.2 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 CDI79319.1 - 3.6 5.9 12.4 3.8 5.8 12.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 CDI79319.1 - 3.8 5.3 25.7 4.5 5.1 25.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PIP5K PF01504.18 CDI79319.1 - 3.9 6.6 18.0 4.4 6.5 18.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Tim54 PF11711.8 CDI79319.1 - 4.3 6.0 18.7 5.1 5.8 18.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM60A PF15396.6 CDI79319.1 - 5 7.1 19.2 5.7 6.9 19.2 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 CDI79319.1 - 5.1 5.8 28.4 6.1 5.5 28.4 1.0 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 CDI79319.1 - 6.1 6.2 23.1 8.1 5.8 23.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CDI79319.1 - 6.4 5.6 15.3 6.8 5.6 15.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CBP_BcsG PF11658.8 CDI79319.1 - 7.4 4.8 19.3 8.8 4.6 19.3 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG CSG2 PF16965.5 CDI79319.1 - 7.7 5.4 13.1 8.6 5.2 13.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator SLC12 PF03522.15 CDI79319.1 - 7.8 5.4 23.9 8.4 5.3 23.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Paf1 PF03985.13 CDI79319.1 - 8.5 5.3 25.8 9.7 5.1 25.8 1.0 1 0 0 1 1 1 0 Paf1 NARP1 PF12569.8 CDI79319.1 - 8.5 5.1 23.1 9.9 4.9 23.1 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Gti1_Pac2 PF09729.9 CDI79319.1 - 9 6.4 19.5 11 6.1 19.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Baculo_PP31 PF05311.11 CDI79319.1 - 9.5 5.6 19.8 13 5.2 19.8 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) TFIIA PF03153.13 CDI79320.1 - 0.012 15.6 5.8 0.012 15.6 5.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4106 PF13388.6 CDI79320.1 - 7.8 5.6 12.5 10 5.2 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Helicase_C PF00271.31 CDI79321.1 - 7.9e-12 45.5 0.1 1.1e-09 38.6 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI79321.1 - 1e-11 44.9 4.5 1e-11 44.9 4.5 3.1 3 1 0 3 3 3 1 DEAD/DEAH box helicase Sporozoite_P67 PF05642.11 CDI79321.1 - 0.00055 18.2 0.1 0.00055 18.2 0.1 6.5 3 3 1 4 4 4 1 Sporozoite P67 surface antigen SecA_DEAD PF07517.14 CDI79321.1 - 0.041 13.2 0.1 0.041 13.2 0.1 2.7 2 0 0 2 2 2 0 SecA DEAD-like domain Helicase_C PF00271.31 CDI79322.1 - 1.1e-16 61.1 0.3 6.4e-16 58.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3439 PF11921.8 CDI79322.1 - 0.008 16.1 4.5 0.022 14.7 0.6 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) DUF4770 PF15994.5 CDI79322.1 - 0.017 15.4 0.2 0.017 15.4 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) DUF4179 PF13786.6 CDI79322.1 - 0.84 10.2 8.6 2.8 8.5 0.5 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) RRM_5 PF13893.6 CDI79323.1 - 1.7e-29 102.0 0.1 6.4e-13 48.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 CDI79323.1 - 2.4e-23 81.7 0.0 3.4e-09 36.4 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 CDI79323.1 - 7.4e-11 42.1 0.5 1.6e-10 41.1 0.1 1.8 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 CDI79323.1 - 1.9e-06 27.7 0.0 0.099 12.5 0.0 3.0 3 0 0 3 3 3 2 Occluded RNA-recognition motif DUF2722 PF10846.8 CDI79323.1 - 0.0022 17.0 6.9 0.003 16.6 6.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Ribosomal_60s PF00428.19 CDI79323.1 - 0.044 14.4 3.2 0.044 14.4 3.2 3.0 4 0 0 4 4 2 0 60s Acidic ribosomal protein Suf PF05843.14 CDI79323.1 - 0.045 13.7 2.1 0.07 13.1 2.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Tox-WTIP PF15654.6 CDI79323.1 - 0.057 13.8 1.0 0.1 13.0 0.0 1.9 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif FAM60A PF15396.6 CDI79323.1 - 0.098 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A TFIIA PF03153.13 CDI79323.1 - 0.11 12.5 13.9 0.18 11.8 13.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Adeno_PIX PF03955.14 CDI79323.1 - 0.14 12.3 5.7 3.3 7.9 0.8 2.5 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) RskA PF10099.9 CDI79323.1 - 0.33 11.2 13.3 1 9.6 4.6 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Spc7_N PF15402.6 CDI79323.1 - 1.1 7.5 6.1 1.8 6.7 6.1 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 FTZ PF03867.14 CDI79323.1 - 2.3 7.7 9.5 4.4 6.8 9.5 1.4 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Chorion_S16 PF05836.12 CDI79323.1 - 6.7 7.0 9.2 0.5 10.6 1.4 2.5 2 0 0 2 2 2 0 Chorion protein S16 Skp1_POZ PF03931.15 CDI79325.1 - 1.3e-19 70.1 0.2 2.3e-19 69.3 0.2 1.4 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Skp1 PF01466.19 CDI79325.1 - 7.7e-19 67.5 0.1 2.9e-18 65.7 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain RNA_pol_Rpc34 PF05158.12 CDI79327.1 - 6.8e-25 88.2 0.3 2.5e-15 56.7 0.1 3.0 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit UBA_3 PF09288.10 CDI79327.1 - 0.061 13.1 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain m04gp34like PF12216.8 CDI79328.1 - 0.019 14.6 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Immune evasion protein Pilin_N PF07790.11 CDI79328.1 - 0.096 13.6 1.6 0.67 10.9 0.8 2.0 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal Tom5 PF10642.9 CDI79328.1 - 0.18 11.9 0.5 0.41 10.7 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase DUF3357 PF11837.8 CDI79328.1 - 0.3 11.5 2.8 0.39 11.2 0.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) Pro_isomerase PF00160.21 CDI79332.1 - 6.6e-36 124.0 0.1 7.1e-36 123.9 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CPBP PF02517.16 CDI79333.1 - 0.013 15.9 1.3 0.022 15.1 1.3 1.4 1 0 0 1 1 1 0 CPBP intramembrane metalloprotease GET2 PF08690.10 CDI79333.1 - 0.4 10.3 3.0 1.4 8.5 0.1 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 Bromodomain PF00439.25 CDI79334.1 - 3.1e-14 52.8 0.0 5.8e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain CbiD PF01888.17 CDI79336.1 - 0.11 11.8 0.1 0.11 11.8 0.1 2.0 2 0 0 2 2 2 0 CbiD Hydrolase_4 PF12146.8 CDI79338.1 - 1.2e-22 80.3 0.0 3.1e-15 56.1 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI79338.1 - 7e-13 48.8 0.1 5.5e-09 36.0 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDI79338.1 - 4.1e-09 36.2 0.0 8.4e-09 35.2 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CDI79338.1 - 1e-08 36.1 0.1 1.5e-07 32.3 0.0 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CDI79338.1 - 4.6e-08 33.0 0.1 0.0073 15.9 0.0 2.6 3 0 0 3 3 3 2 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CDI79338.1 - 4e-07 29.8 0.0 2.6e-06 27.2 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family AXE1 PF05448.12 CDI79338.1 - 5.1e-07 28.7 0.7 0.0018 17.0 0.1 2.2 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 CDI79338.1 - 0.0017 18.1 0.0 0.0053 16.4 0.0 1.8 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 CDI79338.1 - 0.0017 18.1 0.0 0.0049 16.7 0.0 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family BAAT_C PF08840.11 CDI79338.1 - 0.0025 17.8 0.0 0.028 14.3 0.0 2.0 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Thioesterase PF00975.20 CDI79338.1 - 0.0032 17.6 0.0 0.0054 16.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 CDI79338.1 - 0.0059 16.4 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein LIDHydrolase PF10230.9 CDI79338.1 - 0.0079 15.8 0.0 0.85 9.1 0.0 2.3 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 CDI79338.1 - 0.0082 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 CDI79338.1 - 0.013 14.5 0.0 0.2 10.6 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Lipase_3 PF01764.25 CDI79338.1 - 0.023 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 CDI79338.1 - 0.12 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 CDI79338.1 - 0.16 11.8 0.0 0.55 10.0 0.0 1.8 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Clat_adaptor_s PF01217.20 CDI79339.1 - 0.048 13.6 0.1 0.073 13.0 0.1 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Adap_comp_sub PF00928.21 CDI79339.1 - 0.07 12.5 0.0 0.15 11.4 0.0 1.5 1 1 0 1 1 1 0 Adaptor complexes medium subunit family HAUS5 PF14817.6 CDI79340.1 - 0.0048 15.7 33.9 0.009 14.8 33.9 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 TSGP1 PF07771.11 CDI79341.1 - 0.22 11.7 0.1 0.22 11.7 0.1 1.8 2 0 0 2 2 2 0 Tick salivary peptide group 1 FAM176 PF14851.6 CDI79341.1 - 3.2 7.4 4.7 1.5 8.5 0.1 2.5 3 0 0 3 3 3 0 FAM176 family SUIM_assoc PF16619.5 CDI79342.1 - 0.23 11.5 0.0 0.23 11.5 0.0 51.2 22 12 12 35 35 35 0 Unstructured region C-term to UIM in Ataxin3 GCP_C_terminal PF04130.13 CDI79343.1 - 1.9e-28 99.9 6.6 1.9e-28 99.9 6.6 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal AbbA_antirepres PF14156.6 CDI79345.1 - 0.078 12.9 2.0 0.14 12.0 2.0 1.4 1 0 0 1 1 1 0 Antirepressor AbbA Macoilin PF09726.9 CDI79345.1 - 2.6 6.5 16.0 3 6.3 16.0 1.0 1 0 0 1 1 1 0 Macoilin family Ribosomal_60s PF00428.19 CDI79345.1 - 5.2 7.7 15.8 3.4 8.3 13.1 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI79345.1 - 7.9 6.4 28.3 9.3 6.1 28.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GCP_N_terminal PF17681.1 CDI79347.1 - 9.4e-23 81.3 0.3 1.1e-22 81.0 0.3 1.0 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal CASP_C PF08172.12 CDI79347.1 - 0.011 15.1 0.1 0.013 14.9 0.1 1.2 1 0 0 1 1 1 0 CASP C terminal DUF2057 PF09829.9 CDI79347.1 - 0.17 12.0 2.0 0.24 11.5 2.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF3138 PF11336.8 CDI79347.1 - 1.1 7.7 6.9 1.2 7.7 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Pro_isomerase PF00160.21 CDI79350.1 - 1.5e-47 161.8 0.1 1.7e-47 161.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RabGAP-TBC PF00566.18 CDI79352.1 - 0.048 13.3 11.2 0.62 9.7 0.0 4.1 4 0 0 4 4 4 0 Rab-GTPase-TBC domain TERB2 PF15101.6 CDI79352.1 - 7.3 6.6 23.3 5.6 7.0 5.2 2.8 3 0 0 3 3 3 0 Telomere-associated protein TERB2 DUF1645 PF07816.11 CDI79352.1 - 9.1 6.8 46.9 0.31 11.6 16.3 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1645) Ribosomal_L26 PF16906.5 CDI79353.1 - 1.7e-33 114.9 3.4 2.2e-33 114.6 3.4 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CDI79353.1 - 4.4e-08 32.8 3.6 9.4e-08 31.8 3.6 1.6 1 0 0 1 1 1 1 KOW motif DUF2981 PF11200.8 CDI79354.1 - 9.3e-20 71.6 13.1 5.4e-09 36.3 3.1 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF2981) DUF4179 PF13786.6 CDI79355.1 - 5.1 7.6 0.0 4.4 7.9 0.3 6.4 4 2 1 5 5 5 0 Domain of unknown function (DUF4179) Presenilin PF01080.17 CDI79355.1 - 8 5.1 39.2 0.055 12.2 9.7 3.0 3 0 0 3 3 3 0 Presenilin DRIM PF07539.12 CDI79356.1 - 0.075 11.3 0.0 0.18 10.1 0.0 1.5 1 0 0 1 1 1 0 Down-regulated in metastasis Nucleoporin2 PF04096.14 CDI79357.1 - 1.4e-39 135.6 0.2 5e-39 133.8 0.0 2.1 2 0 0 2 2 2 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CDI79357.1 - 8.7e-29 100.2 333.8 7.5e-08 33.1 35.6 13.1 5 3 7 12 12 12 9 Nucleoporin FG repeat region Ribosomal_60s PF00428.19 CDI79360.1 - 0.072 13.7 6.5 0.12 12.9 6.5 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein ANAPC4_WD40 PF12894.7 CDI79361.1 - 0.00095 19.4 0.0 0.39 11.1 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI79361.1 - 0.0064 17.3 4.8 4.5 8.3 0.0 5.3 5 1 0 5 5 5 2 WD domain, G-beta repeat LOR PF04525.12 CDI79361.1 - 0.082 12.5 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 LURP-one-related RNA_pol_Rpb2_1 PF04563.15 CDI79363.1 - 5.3e-60 202.4 0.0 7.3e-60 201.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CDI79363.1 - 4.7e-48 163.3 0.0 8.3e-48 162.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_6 PF00562.28 CDI79363.1 - 7.8e-41 140.4 0.0 1.1e-40 139.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 CDI79363.1 - 2.5e-26 91.6 0.0 5.4e-26 90.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 CDI79363.1 - 1.2e-20 73.5 0.1 2.4e-20 72.6 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 CDI79363.1 - 1.6e-16 60.6 1.9 1.6e-16 60.6 1.9 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 Androgen_recep PF02166.16 CDI79363.1 - 0.41 9.4 3.7 0.66 8.8 3.7 1.2 1 0 0 1 1 1 0 Androgen receptor Peptidase_M16_C PF05193.21 CDI79366.1 - 0.0017 18.4 6.4 0.35 10.8 0.0 3.4 3 1 1 4 4 3 2 Peptidase M16 inactive domain EPL1 PF10513.9 CDI79366.1 - 0.048 14.1 17.1 0.14 12.5 4.2 3.3 4 0 0 4 4 3 0 Enhancer of polycomb-like MecA PF05389.12 CDI79366.1 - 0.063 12.9 12.0 0.057 13.1 4.4 2.6 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) CNDH2_C PF16858.5 CDI79366.1 - 0.086 12.7 18.2 0.095 12.6 10.8 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Pox_Ag35 PF03286.14 CDI79366.1 - 0.35 10.6 10.5 0.013 15.3 2.8 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein SpoIIP PF07454.11 CDI79366.1 - 0.35 10.3 15.6 0.74 9.2 9.7 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI79366.1 - 0.51 9.0 17.7 0.038 12.8 6.3 2.4 2 0 0 2 2 2 0 Presenilin DUF5523 PF17661.1 CDI79366.1 - 0.57 9.8 16.7 0.089 12.5 9.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) MAT1 PF06391.13 CDI79366.1 - 0.77 9.5 27.3 1.8 8.3 17.8 2.7 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 EOS1 PF12326.8 CDI79366.1 - 0.88 9.5 3.5 2.3 8.1 0.8 2.5 2 0 0 2 2 2 0 N-glycosylation protein Connexin PF00029.19 CDI79366.1 - 0.98 9.1 9.5 0.16 11.7 2.3 2.7 3 0 0 3 3 3 0 Connexin Rxt3 PF08642.10 CDI79366.1 - 1.5 9.6 11.9 5.9 7.7 0.2 3.2 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 OATP PF03137.20 CDI79366.1 - 2.2 6.5 10.2 1.5 7.1 4.3 2.9 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Baculo_PP31 PF05311.11 CDI79366.1 - 2.3 7.6 11.7 0.21 11.1 3.3 2.5 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Plasmodium_Vir PF05795.11 CDI79366.1 - 3 7.2 7.6 1.2 8.5 2.5 2.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Band_3_cyto PF07565.13 CDI79366.1 - 5.7 6.7 19.6 6.9 6.4 6.7 3.9 4 0 0 4 4 4 0 Band 3 cytoplasmic domain Eapp_C PF10238.9 CDI79366.1 - 7 6.7 16.3 1.3 9.1 7.4 2.7 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF5327 PF17261.2 CDI79366.1 - 7.3 7.4 25.8 0.33 11.7 8.8 3.8 4 0 0 4 4 4 0 Family of unknown function (DUF5327) SID-1_RNA_chan PF13965.6 CDI79366.1 - 8.2 4.7 7.4 1.2 7.5 2.7 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PPL5 PF18168.1 CDI79366.1 - 9.5 5.4 12.3 0.82 8.9 5.4 2.2 2 0 0 2 2 2 0 Prim-pol family 5 Ank_4 PF13637.6 CDI79367.1 - 1e-18 67.4 0.3 7.7e-12 45.5 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI79367.1 - 1.2e-15 57.4 0.1 8.7e-07 29.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI79367.1 - 1.6e-14 54.2 0.2 5.3e-14 52.6 0.1 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDI79367.1 - 1.6e-13 50.4 0.3 1.8e-05 24.9 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 CDI79367.1 - 7.8e-11 41.2 0.1 0.0027 18.1 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Pol_alpha_B_N PF08418.10 CDI79367.1 - 0.15 12.0 5.5 0.22 11.5 5.1 1.4 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal AFT PF08731.11 CDI79370.1 - 0.1 13.0 4.2 7.3 7.0 1.4 2.5 3 0 0 3 3 3 0 Transcription factor AFT Spt20 PF12090.8 CDI79370.1 - 0.16 11.5 21.6 0.019 14.6 16.8 1.8 2 0 0 2 2 2 0 Spt20 family Roughex PF06020.11 CDI79370.1 - 1 8.4 10.3 2.3 7.2 10.3 1.6 1 0 0 1 1 1 0 Drosophila roughex protein DUF2722 PF10846.8 CDI79371.1 - 9.3e-05 21.6 2.5 9.3e-05 21.6 2.5 8.6 4 3 2 6 6 6 1 Protein of unknown function (DUF2722) PRP1_N PF06424.12 CDI79371.1 - 0.0028 18.1 0.6 0.0028 18.1 0.6 5.3 4 1 0 4 4 4 2 PRP1 splicing factor, N-terminal Activator_LAG-3 PF11498.8 CDI79371.1 - 0.0047 16.0 10.5 0.0047 16.0 10.5 5.2 4 1 0 4 4 4 1 Transcriptional activator LAG-3 DUF2371 PF10177.9 CDI79371.1 - 0.36 11.0 0.0 0.36 11.0 0.0 5.2 5 1 0 5 5 5 0 Uncharacterised conserved protein (DUF2371) Apt1 PF10351.9 CDI79371.1 - 0.84 8.4 0.0 0.84 8.4 0.0 4.7 3 2 1 4 4 4 0 Golgi-body localisation protein domain OATP PF03137.20 CDI79372.1 - 0.0005 18.5 0.3 0.0014 17.0 0.2 1.7 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2681 PF10883.8 CDI79372.1 - 0.0031 17.9 0.4 0.0031 17.9 0.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2681) MFS_1_like PF12832.7 CDI79372.1 - 0.0049 15.8 0.0 0.047 12.5 0.0 2.1 1 1 1 2 2 2 1 MFS_1 like family Ctr PF04145.15 CDI79372.1 - 0.075 13.7 2.7 5.7 7.5 0.0 2.7 2 1 0 2 2 2 0 Ctr copper transporter family DUF4400 PF14348.6 CDI79372.1 - 0.1 12.1 5.5 0.076 12.5 2.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4400) DUF4614 PF15391.6 CDI79372.1 - 0.73 9.8 7.0 0.066 13.2 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) MFS_2 PF13347.6 CDI79372.1 - 1.7 7.1 14.8 2.2 6.7 12.5 2.2 2 1 0 2 2 2 0 MFS/sugar transport protein SET PF00856.28 CDI79373.1 - 0.061 13.7 0.0 0.078 13.4 0.0 1.2 1 0 0 1 1 1 0 SET domain Glyco_hydro_67N PF03648.14 CDI79373.1 - 0.066 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus NAPRTase_C PF17956.1 CDI79374.1 - 6.4e-27 94.2 0.0 9.4e-27 93.6 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 CDI79374.1 - 2.3e-09 37.3 0.0 9e-08 32.0 0.0 2.1 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family CPSF_A PF03178.15 CDI79376.1 - 2.1e-13 50.3 0.0 2.4e-10 40.2 0.0 2.3 2 0 0 2 2 2 2 CPSF A subunit region BP28CT PF08146.12 CDI79377.1 - 0.35 10.7 9.5 1.2 9.0 0.0 4.7 5 0 0 5 5 5 0 BP28CT (NUC211) domain eIF-6 PF01912.18 CDI79378.1 - 8.7e-76 253.7 0.1 1.3e-75 253.1 0.1 1.2 1 0 0 1 1 1 1 eIF-6 family MCM PF00493.23 CDI79379.1 - 2.5e-16 59.4 6.3 6e-10 38.6 0.3 3.6 2 1 1 3 3 3 3 MCM P-loop domain MCM_lid PF17855.1 CDI79379.1 - 1.6e-10 41.3 0.1 4e-10 40.0 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain G-alpha PF00503.20 CDI79379.1 - 0.013 14.7 0.3 0.061 12.5 0.3 1.9 2 0 0 2 2 2 0 G-protein alpha subunit RskA PF10099.9 CDI79382.1 - 0.0029 18.0 14.7 0.0029 18.0 14.7 12.1 2 2 4 8 8 8 1 Anti-sigma-K factor rskA zf-RanBP PF00641.18 CDI79383.1 - 0.021 14.2 31.3 0.39 10.1 13.1 2.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Pkinase PF00069.25 CDI79385.1 - 6.4e-08 32.3 0.0 1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79385.1 - 1.4e-05 24.5 0.0 2.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI79385.1 - 0.00069 19.0 0.0 0.00092 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AP2 PF00847.20 CDI79386.1 - 3.3e-06 27.2 2.4 0.0075 16.5 0.7 2.4 2 0 0 2 2 2 2 AP2 domain ProRS-C_1 PF09180.11 CDI79387.1 - 7.5e-20 70.9 0.0 1.8e-19 69.7 0.0 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 CDI79387.1 - 6.3e-19 67.9 0.0 3.6e-18 65.5 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CDI79387.1 - 1.1e-18 67.8 0.0 3.4e-18 66.2 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 CDI79387.1 - 2.8e-13 50.0 0.1 6.4e-09 35.9 0.1 2.4 1 1 1 2 2 2 2 Aminoacyl-tRNA editing domain Cas_Cas1 PF01867.16 CDI79387.1 - 0.0047 16.1 0.0 0.0086 15.2 0.0 1.3 1 0 0 1 1 1 1 CRISPR associated protein Cas1 Adenyl_cycl_N PF12633.7 CDI79388.1 - 0.0041 17.0 0.7 0.015 15.2 0.7 2.0 1 1 0 1 1 1 1 Adenylate cyclase NT domain RskA PF10099.9 CDI79388.1 - 0.019 15.2 0.0 0.019 15.2 0.0 8.1 2 1 4 8 8 8 0 Anti-sigma-K factor rskA FxsA PF04186.13 CDI79388.1 - 5.2 7.2 8.3 27 4.9 0.0 4.3 4 0 0 4 4 4 0 FxsA cytoplasmic membrane protein DUF726 PF05277.12 CDI79389.1 - 8.6e-104 347.1 2.2 3.7e-53 180.6 0.5 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF726) DUF1018 PF06252.12 CDI79389.1 - 3.9 8.5 15.9 0.15 13.0 2.9 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) Bromodomain PF00439.25 CDI79390.1 - 1.5e-30 105.1 0.0 2.8e-15 56.1 0.0 2.4 2 0 0 2 2 2 2 Bromodomain Rer1 PF03248.13 CDI79391.1 - 2e-61 206.7 2.4 2.5e-61 206.4 2.4 1.1 1 0 0 1 1 1 1 Rer1 family RBM1CTR PF08081.11 CDI79394.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 RBM1CTR (NUC064) family IPPT PF01715.17 CDI79400.1 - 2.3e-51 174.8 0.0 6.1e-26 91.6 0.0 2.3 1 1 1 2 2 2 2 IPP transferase HTH_17 PF12728.7 CDI79400.1 - 0.0076 16.4 0.1 0.033 14.4 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain AAA_33 PF13671.6 CDI79400.1 - 0.017 15.3 0.0 0.062 13.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain IPT PF01745.16 CDI79400.1 - 0.025 14.0 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA_16 PF13191.6 CDI79400.1 - 0.034 14.5 0.0 0.091 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.15 CDI79400.1 - 0.049 13.5 0.1 1.6 8.6 0.0 2.5 3 0 0 3 3 3 0 NTPase ATPase_2 PF01637.18 CDI79400.1 - 0.053 13.4 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CDI79400.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 CDI79400.1 - 0.18 11.2 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein TPK_catalytic PF04263.16 CDI79402.1 - 3.4e-31 107.8 0.0 1.1e-30 106.1 0.0 1.8 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 CDI79402.1 - 2.3e-14 52.9 0.0 4.3e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain SUIM_assoc PF16619.5 CDI79402.1 - 0.0023 17.9 2.2 0.0023 17.9 2.2 1.9 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF3464 PF11947.8 CDI79402.1 - 0.0029 17.4 2.2 0.028 14.2 0.1 2.2 2 0 0 2 2 2 1 Photosynthesis affected mutant 68 DUF702 PF05142.12 CDI79402.1 - 5.6 7.4 8.1 26 5.2 3.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) RhodobacterPufX PF11511.8 CDI79403.1 - 0.075 12.7 0.3 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Intrinsic membrane protein PufX AP2 PF00847.20 CDI79404.1 - 2e-09 37.5 0.2 1.1e-08 35.1 0.2 2.4 1 0 0 1 1 1 1 AP2 domain RskA PF10099.9 CDI79404.1 - 0.02 15.2 1.1 0.02 15.2 1.1 9.2 3 3 2 6 6 6 0 Anti-sigma-K factor rskA Tim54 PF11711.8 CDI79405.1 - 0.0013 17.6 2.3 0.0013 17.6 2.3 5.0 5 1 0 5 5 5 1 Inner membrane protein import complex subunit Tim54 PIP5K PF01504.18 CDI79405.1 - 0.062 12.5 28.0 0.33 10.1 9.2 5.1 5 0 0 5 5 5 0 Phosphatidylinositol-4-phosphate 5-Kinase GWT1 PF06423.12 CDI79405.1 - 4.2 7.5 4.3 35 4.5 0.8 4.2 3 0 0 3 3 3 0 GWT1 tRNA-synt_1e PF01406.19 CDI79406.1 - 9.2e-102 340.4 0.9 6.6e-67 226.0 0.1 2.8 2 2 1 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDI79406.1 - 3.8e-11 42.4 0.6 5.1e-05 22.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 CDI79406.1 - 0.0031 16.5 0.0 0.08 11.8 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (K) Med3 PF11593.8 CDI79406.1 - 0.0056 15.9 1.5 0.0056 15.9 1.5 2.3 3 0 0 3 3 3 1 Mediator complex subunit 3 fungal tRNA-synt_1 PF00133.22 CDI79406.1 - 0.01 14.1 0.0 0.054 11.7 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (I, L, M and V) Spt20 PF12090.8 CDI79406.1 - 0.14 11.7 18.2 0.31 10.6 18.2 1.6 1 0 0 1 1 1 0 Spt20 family PhoLip_ATPase_C PF16212.5 CDI79409.1 - 4.7e-61 206.7 13.6 8.9e-61 205.8 13.6 1.4 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDI79409.1 - 1e-22 79.6 0.6 1e-22 79.6 0.6 2.2 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDI79409.1 - 9.2e-09 35.9 7.3 8.5e-05 22.9 0.1 4.2 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI79409.1 - 0.00029 20.8 0.2 0.033 14.3 0.0 3.5 3 1 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CDI79409.1 - 0.0067 16.2 0.0 0.0067 16.2 0.0 2.9 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI79409.1 - 0.099 12.2 0.0 0.099 12.2 0.0 3.0 4 0 0 4 4 4 0 E1-E2 ATPase RskA PF10099.9 CDI79409.1 - 0.17 12.2 20.8 0.17 12.2 4.6 4.2 4 0 0 4 4 4 0 Anti-sigma-K factor rskA Velvet PF11754.8 CDI79409.1 - 0.63 9.9 14.0 0.22 11.4 1.8 3.6 4 0 0 4 4 4 0 Velvet factor RskA PF10099.9 CDI79410.1 - 0.0031 17.8 9.9 0.0031 17.8 9.9 8.0 2 2 4 6 6 6 4 Anti-sigma-K factor rskA DDHD PF02862.17 CDI79411.1 - 7.4e-05 23.0 15.9 0.054 13.6 10.5 3.6 3 0 0 3 3 3 2 DDHD domain TFIIA PF03153.13 CDI79411.1 - 0.00027 21.0 4.7 0.00027 21.0 4.7 4.1 2 1 0 3 3 2 1 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI79411.1 - 0.0009 18.8 9.4 0.0009 18.8 9.4 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 CDI79411.1 - 0.0014 18.7 17.0 0.25 11.4 11.1 3.3 3 0 0 3 3 3 2 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI79411.1 - 0.02 13.7 34.5 0.16 10.7 23.4 3.1 3 0 0 3 3 3 0 Presenilin SpoIIP PF07454.11 CDI79411.1 - 0.4 10.1 31.3 0.34 10.3 18.0 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Isy1 PF06246.12 CDI79411.1 - 0.89 9.1 25.5 5.7 6.4 0.0 3.4 3 0 0 3 3 3 0 Isy1-like splicing family SID-1_RNA_chan PF13965.6 CDI79411.1 - 1.1 7.6 11.8 2.9 6.2 7.9 2.7 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 LAP1C PF05609.12 CDI79411.1 - 1.1 8.2 30.5 0.3 10.1 19.0 3.2 3 0 0 3 3 3 0 Lamina-associated polypeptide 1C (LAP1C) TCP PF03634.13 CDI79411.1 - 1.3 9.6 34.7 3.9 8.0 0.1 3.7 4 0 0 4 4 4 0 TCP family transcription factor Connexin PF00029.19 CDI79411.1 - 1.8 8.3 25.7 6.2 6.5 14.0 3.5 3 0 0 3 3 3 0 Connexin SAPS PF04499.15 CDI79411.1 - 3 6.5 20.8 0.54 9.0 12.2 2.8 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein ESM4 PF15952.5 CDI79411.1 - 3.3 8.1 47.4 0.11 12.9 22.0 3.4 3 0 0 3 3 3 0 Enhancer of split M4 family Serinc PF03348.15 CDI79411.1 - 3.5 6.5 15.2 5.2 5.9 8.8 3.0 3 0 0 3 3 3 0 Serine incorporator (Serinc) DUF913 PF06025.12 CDI79411.1 - 3.9 6.3 18.3 7.4 5.4 14.6 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Lin-8 PF03353.15 CDI79411.1 - 4.1 6.9 39.6 0.032 13.8 19.5 3.4 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist ASD2 PF08687.11 CDI79411.1 - 5.7 6.4 38.4 0.3 10.6 21.9 3.5 3 0 0 3 3 3 0 Apx/Shroom domain ASD2 BORG_CEP PF14957.6 CDI79411.1 - 6.8 7.9 32.1 0.1 13.8 13.1 4.0 3 1 0 3 3 2 0 Cdc42 effector AAA_11 PF13086.6 CDI79411.1 - 8.6 6.1 31.2 1.4 8.6 19.1 3.2 3 0 0 3 3 3 0 AAA domain SF1-HH PF16275.5 CDI79412.1 - 4e-27 94.8 0.0 9.2e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 CDI79412.1 - 1.7e-09 37.4 0.1 3.1e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 CDI79412.1 - 2.6e-05 24.1 4.0 0.0073 16.3 0.5 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 CDI79412.1 - 0.001 19.0 1.9 0.42 10.6 0.4 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 CDI79412.1 - 0.0032 17.2 3.3 0.91 9.3 0.2 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-RING_9 PF13901.6 CDI79412.1 - 0.0041 17.1 1.0 0.007 16.4 1.0 1.2 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon zf-LSD1 PF06943.12 CDI79412.1 - 5.6 6.9 6.9 10 6.1 0.2 2.7 2 0 0 2 2 2 0 LSD1 zinc finger DUF1077 PF06417.12 CDI79414.1 - 5.4e-09 36.1 0.0 2.7e-08 33.8 0.0 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Spt20 PF12090.8 CDI79414.1 - 2.6e-05 24.0 23.6 2.6e-05 24.0 23.6 10.1 8 1 0 8 8 8 5 Spt20 family CNDH2_C PF16858.5 CDI79414.1 - 0.0055 16.6 2.9 0.0055 16.6 2.9 6.4 6 2 0 6 6 6 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term Pkinase PF00069.25 CDI79415.1 - 5.6e-38 130.8 0.1 6.7e-37 127.3 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79415.1 - 2.7e-16 59.6 0.1 1e-15 57.7 0.1 1.9 1 1 1 2 2 2 1 Protein tyrosine kinase TFIIA PF03153.13 CDI79415.1 - 0.0014 18.7 20.4 0.0016 18.5 20.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Kdo PF06293.14 CDI79415.1 - 0.0035 16.7 0.0 0.0035 16.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDI79415.1 - 0.013 14.3 0.1 0.013 14.3 0.1 2.1 1 1 0 2 2 1 0 Fungal protein kinase DDHD PF02862.17 CDI79415.1 - 0.028 14.6 1.7 0.035 14.3 1.7 1.3 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 CDI79415.1 - 0.029 12.7 11.7 0.03 12.6 11.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI79415.1 - 0.038 12.7 4.6 0.043 12.6 4.6 1.1 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDI79415.1 - 0.06 12.3 7.8 0.074 12.0 7.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) YrbL-PhoP_reg PF10707.9 CDI79415.1 - 0.07 12.6 7.3 3.5 7.1 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Tho2 PF11262.8 CDI79415.1 - 0.2 10.8 7.3 0.34 10.1 7.3 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Ndc1_Nup PF09531.10 CDI79415.1 - 0.21 10.3 2.4 0.23 10.1 2.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EIIBC-GUT_N PF03612.14 CDI79415.1 - 0.26 11.0 2.8 0.46 10.2 2.8 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus UPF0560 PF10577.9 CDI79415.1 - 0.37 9.2 10.2 0.46 8.9 10.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4834 PF16118.5 CDI79415.1 - 0.4 11.7 10.3 0.75 10.8 10.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Neur_chan_memb PF02932.16 CDI79415.1 - 0.41 10.7 1.0 0.44 10.6 1.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Baculo_PP31 PF05311.11 CDI79415.1 - 0.51 9.8 5.4 0.7 9.3 5.4 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) MDM10 PF12519.8 CDI79415.1 - 0.57 9.0 6.7 0.72 8.6 6.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SpoIIP PF07454.11 CDI79415.1 - 0.63 9.4 7.3 0.94 8.9 7.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI79415.1 - 0.99 8.4 3.9 1.4 7.9 3.9 1.2 1 0 0 1 1 1 0 CLN3 protein OATP PF03137.20 CDI79415.1 - 1 7.6 2.0 1.4 7.2 2.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FTA2 PF13095.6 CDI79415.1 - 1.6 8.3 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HD-ZIP_N PF04618.12 CDI79415.1 - 2.2 8.9 5.0 3.9 8.0 5.0 1.3 1 0 0 1 1 1 0 HD-ZIP protein N terminus Band_3_cyto PF07565.13 CDI79415.1 - 2.7 7.7 8.1 4 7.2 8.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Connexin PF00029.19 CDI79415.1 - 2.9 7.6 5.4 4.1 7.1 5.4 1.1 1 0 0 1 1 1 0 Connexin FlaG PF03646.15 CDI79415.1 - 5.2 7.3 15.9 11 6.3 15.9 1.5 1 0 0 1 1 1 0 FlaG protein Di19_C PF14571.6 CDI79415.1 - 7.9 7.1 10.7 15 6.2 10.7 1.4 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal DUF1980 PF09323.10 CDI79415.1 - 8.8 6.2 8.1 15 5.5 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Ras PF00071.22 CDI79417.1 - 6.2e-39 133.2 0.0 6.8e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI79417.1 - 1.2e-30 106.2 0.0 1.4e-30 106.0 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI79417.1 - 1.1e-10 41.3 0.0 1.1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDI79417.1 - 9.3e-05 22.5 0.0 0.00011 22.3 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDI79417.1 - 0.00097 18.6 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 CDI79417.1 - 0.0079 16.6 0.0 0.0079 16.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain ArgoMid PF16487.5 CDI79417.1 - 0.0087 16.3 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 Mid domain of argonaute RNA_helicase PF00910.22 CDI79417.1 - 0.0096 16.3 0.1 0.079 13.4 0.1 2.0 1 1 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 CDI79417.1 - 0.022 14.3 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 CDI79417.1 - 0.024 13.8 0.1 0.043 13.0 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 CDI79417.1 - 0.03 14.2 0.1 0.03 14.2 0.1 1.2 1 0 0 1 1 1 0 NTPase Septin PF00735.18 CDI79417.1 - 0.062 12.6 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 CDI79417.1 - 0.09 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CDI79417.1 - 0.097 12.9 0.1 0.21 11.8 0.1 1.5 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDI79417.1 - 0.12 12.5 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDI79417.1 - 0.13 12.3 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 CDI79417.1 - 0.14 12.1 0.1 0.18 11.7 0.1 1.2 1 0 0 1 1 1 0 NACHT domain DAP3 PF10236.9 CDI79417.1 - 0.14 11.3 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 TsaE PF02367.17 CDI79417.1 - 0.14 12.1 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 CDI79417.1 - 0.15 11.7 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 CDI79417.1 - 0.17 11.7 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 CDI79417.1 - 0.17 11.3 0.0 0.74 9.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein Suf PF05843.14 CDI79418.1 - 2.1e-05 24.7 24.4 0.087 12.8 0.0 5.7 4 2 2 6 6 6 2 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 CDI79418.1 - 2.6e-05 24.2 18.1 0.083 12.9 0.4 6.4 6 1 1 7 7 7 2 Mad3/BUB1 homology region 1 NRDE-2 PF08424.10 CDI79418.1 - 0.0012 18.1 0.7 0.0012 18.1 0.7 4.9 2 2 2 4 4 4 1 NRDE-2, necessary for RNA interference RPN7 PF10602.9 CDI79418.1 - 0.049 13.3 18.2 0.36 10.5 2.5 5.0 4 1 1 5 5 5 0 26S proteasome subunit RPN7 TPR_8 PF13181.6 CDI79418.1 - 0.19 12.0 15.6 2 8.8 0.2 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI79418.1 - 0.23 12.4 0.1 0.23 12.4 0.1 13.7 14 4 4 18 18 18 0 Tetratricopeptide repeat CKAP2_C PF15297.6 CDI79418.1 - 0.96 8.5 9.0 2.6 7.1 0.0 3.2 2 1 1 3 3 3 0 Cytoskeleton-associated protein 2 C-terminus TPR_1 PF00515.28 CDI79418.1 - 1 9.3 5.6 3.5 7.6 0.2 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF572 PF04502.13 CDI79418.1 - 2.9 7.4 7.7 5.6 6.5 7.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) TPR_2 PF07719.17 CDI79418.1 - 4.6 7.6 30.3 2.8 8.3 0.1 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat EF-hand_6 PF13405.6 CDI79419.1 - 2.5e-05 23.8 0.1 0.00011 21.8 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 CDI79419.1 - 0.00019 20.7 1.6 0.00027 20.3 0.6 1.7 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 CDI79419.1 - 0.00038 19.8 0.8 0.00083 18.7 0.8 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDI79419.1 - 0.0012 19.3 0.3 0.0017 18.8 0.3 1.4 1 1 0 1 1 1 1 EF-hand domain pair SNase PF00565.17 CDI79420.1 - 1.1e-11 45.2 0.5 4.4e-08 33.6 0.0 3.6 3 1 1 4 4 4 2 Staphylococcal nuclease homologue MAJIN PF15077.6 CDI79421.1 - 0.012 15.4 1.5 0.012 15.4 1.5 8.1 5 2 4 9 9 9 0 Membrane-anchored junction protein EF-hand_7 PF13499.6 CDI79422.1 - 1.6e-11 44.5 0.5 1.2e-05 25.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI79422.1 - 2.4e-10 39.5 5.5 0.00013 21.6 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDI79422.1 - 2.3e-08 33.0 6.2 0.0018 17.7 0.0 3.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 CDI79422.1 - 2.5e-05 24.0 2.2 0.2 11.5 0.0 3.3 2 1 1 3 3 3 3 EF-hand domain pair DUF1456 PF07308.13 CDI79422.1 - 0.022 15.1 0.2 3.4 8.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) EF-hand_9 PF14658.6 CDI79422.1 - 0.028 14.7 0.0 0.98 9.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain UxaC PF02614.14 CDI79422.1 - 0.049 12.5 0.2 0.53 9.1 0.0 1.9 2 0 0 2 2 2 0 Glucuronate isomerase EF-hand_5 PF13202.6 CDI79422.1 - 0.05 13.1 9.9 0.31 10.6 1.7 2.9 3 0 0 3 3 3 0 EF hand EF-hand_14 PF17959.1 CDI79422.1 - 0.067 13.5 0.3 1.7 9.0 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain Shadoo PF14999.6 CDI79422.1 - 0.092 12.8 12.5 0.17 12.0 12.5 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Tic110 PF16940.5 CDI79422.1 - 1 7.7 11.3 1.9 6.9 11.3 1.4 1 1 0 1 1 1 0 Chloroplast envelope transporter Macro PF01661.21 CDI79424.1 - 9.4e-05 22.4 2.9 0.0021 18.1 0.0 3.4 2 1 1 3 3 3 1 Macro domain SUIM_assoc PF16619.5 CDI79424.1 - 0.00053 20.0 5.7 0.00053 20.0 5.7 6.9 5 2 1 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI79424.1 - 0.013 14.3 8.6 0.16 10.7 2.8 2.4 2 0 0 2 2 2 0 Presenilin DUF2828 PF11443.8 CDI79424.1 - 0.15 10.2 8.6 3.7 5.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Bac_surface_Ag PF01103.23 CDI79426.1 - 1.2e-10 41.5 0.0 4.8e-10 39.4 0.0 1.9 1 1 0 1 1 1 1 Surface antigen DUF4667 PF15700.5 CDI79426.1 - 6.3 6.8 12.9 3.3 7.7 1.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) AAA PF00004.29 CDI79428.1 - 1.6e-51 174.2 0.0 1.1e-38 132.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI79428.1 - 1.9e-10 40.3 0.6 5.3e-10 39.0 0.6 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDI79428.1 - 2.8e-10 40.8 2.6 0.00029 21.2 0.0 3.2 3 1 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CDI79428.1 - 1.1e-09 38.4 0.1 0.001 19.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDI79428.1 - 1.6e-09 38.2 0.9 0.0032 17.7 0.1 4.2 2 2 0 3 3 3 1 AAA domain TIP49 PF06068.13 CDI79428.1 - 2.5e-08 33.5 0.0 0.0016 17.7 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 CDI79428.1 - 2.3e-07 31.4 0.0 0.015 15.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.12 CDI79428.1 - 2.5e-07 30.6 0.2 0.026 14.3 0.1 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDI79428.1 - 3.7e-07 29.7 0.1 0.014 14.8 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CDI79428.1 - 4.8e-07 29.8 0.4 0.019 14.9 0.0 3.8 3 1 0 3 3 3 2 NACHT domain CDC48_2 PF02933.17 CDI79428.1 - 2e-06 27.5 0.5 4e-05 23.3 0.1 2.5 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 CDI79428.1 - 2.1e-06 28.0 0.0 0.055 13.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 CDI79428.1 - 6e-06 26.3 0.1 0.047 13.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDI79428.1 - 6.8e-06 26.4 0.0 0.071 13.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.14 CDI79428.1 - 9.2e-06 25.9 0.0 0.0018 18.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CDI79428.1 - 2.7e-05 24.5 0.0 0.31 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDI79428.1 - 6e-05 22.9 0.1 0.18 11.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_24 PF13479.6 CDI79428.1 - 6.4e-05 22.8 0.0 0.051 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CDI79428.1 - 8.4e-05 22.1 0.1 0.032 13.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_3 PF07726.11 CDI79428.1 - 8.8e-05 22.4 0.0 0.65 9.9 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CDI79428.1 - 0.00017 21.9 0.1 0.52 10.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 CDI79428.1 - 0.0002 21.1 0.0 0.083 12.6 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 CDI79428.1 - 0.00022 20.9 0.0 0.72 9.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 CDI79428.1 - 0.00036 20.0 0.1 0.038 13.3 0.0 2.3 2 0 0 2 2 2 1 KaiC PhoH PF02562.16 CDI79428.1 - 0.00042 19.8 0.0 0.94 8.9 0.0 2.5 2 1 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.9 CDI79428.1 - 0.0005 19.4 0.0 0.66 9.1 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 CDI79428.1 - 0.00068 18.9 0.2 1.2 8.3 0.0 2.5 2 1 0 2 2 2 2 NB-ARC domain ATPase_2 PF01637.18 CDI79428.1 - 0.0011 18.9 0.2 1.7 8.5 0.2 3.7 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea ResIII PF04851.15 CDI79428.1 - 0.0012 18.8 0.0 2.2 8.3 0.0 2.5 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_14 PF13173.6 CDI79428.1 - 0.0014 18.7 0.0 0.64 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CDI79428.1 - 0.0015 19.0 0.2 0.12 12.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_11 PF13086.6 CDI79428.1 - 0.0016 18.2 0.0 0.61 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 CDI79428.1 - 0.0031 17.0 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 CDI79428.1 - 0.0038 16.5 0.5 0.38 10.0 0.1 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 CDI79428.1 - 0.0044 16.6 2.7 1.8 8.1 0.1 2.9 2 2 1 3 3 3 2 AAA domain AAA_17 PF13207.6 CDI79428.1 - 0.0048 17.3 0.2 2.5 8.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 CDI79428.1 - 0.011 14.9 0.0 0.23 10.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Rad17 PF03215.15 CDI79428.1 - 0.019 14.9 0.4 3.2 7.6 0.0 3.3 3 1 0 4 4 3 0 Rad17 P-loop domain NTPase_1 PF03266.15 CDI79428.1 - 0.021 14.8 0.0 8.5 6.3 0.0 2.5 2 0 0 2 2 2 0 NTPase Vps4_C PF09336.10 CDI79428.1 - 0.049 13.6 0.1 0.82 9.7 0.0 2.8 3 0 0 3 3 2 0 Vps4 C terminal oligomerisation domain AAA_29 PF13555.6 CDI79428.1 - 0.075 12.8 0.2 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain CPT PF07931.12 CDI79428.1 - 0.077 12.8 0.1 0.47 10.3 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 CDI79428.1 - 0.12 12.3 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase TniB PF05621.11 CDI79428.1 - 0.15 11.4 0.1 4.6 6.6 0.0 2.7 2 1 1 3 3 3 0 Bacterial TniB protein Viral_helicase1 PF01443.18 CDI79428.1 - 0.16 11.7 0.0 1.3 8.7 0.0 2.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase CbiA PF01656.23 CDI79428.1 - 0.49 10.5 1.7 27 4.8 0.1 2.6 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF4201 PF13870.6 CDI79430.1 - 7.1e-19 68.2 15.8 7.1e-19 68.2 15.8 4.7 3 1 0 4 4 4 1 Domain of unknown function (DUF4201) Ank_2 PF12796.7 CDI79430.1 - 3.9e-05 24.1 0.7 0.00023 21.7 0.1 2.5 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI79430.1 - 0.00037 21.0 0.7 0.96 10.1 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI79430.1 - 0.78 10.5 2.1 11 6.9 0.2 3.5 4 1 0 4 4 4 0 Ankyrin repeat Ank_2 PF12796.7 CDI79431.1 - 2e-30 105.2 16.4 7.9e-10 39.2 2.7 5.2 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank PF00023.30 CDI79431.1 - 3.9e-27 93.5 12.4 0.00019 21.8 0.0 7.9 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 CDI79431.1 - 3.6e-24 84.5 8.9 1.7e-09 37.8 0.1 6.0 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI79431.1 - 1.2e-22 79.9 6.5 1e-07 32.4 0.3 6.6 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI79431.1 - 4.8e-18 63.4 5.2 0.062 13.9 0.0 7.2 7 0 0 7 7 7 5 Ankyrin repeat Sushi PF00084.20 CDI79431.1 - 2.7e-07 31.1 0.1 5.2e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) AF-4 PF05110.13 CDI79431.1 - 3.1 5.8 68.8 4.2 5.3 68.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DnaJ PF00226.31 CDI79432.1 - 6.7e-20 71.0 0.4 1.4e-19 69.9 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 CDI79432.1 - 1.4e-15 57.1 0.1 2.1e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Sec63 Brl domain Vps55 PF04133.14 CDI79432.1 - 0.17 11.8 1.3 1.1 9.2 0.1 2.6 3 0 0 3 3 3 0 Vacuolar protein sorting 55 BTB PF00651.31 CDI79433.1 - 0.0019 18.4 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ribosomal_L27 PF01016.19 CDI79434.1 - 2.1e-12 46.9 0.5 8e-12 45.0 0.5 1.8 1 1 0 1 1 1 1 Ribosomal L27 protein Plasmodium_Vir PF05795.11 CDI79437.1 - 0.00086 18.8 1.7 0.00086 18.8 1.7 3.0 2 1 1 3 3 3 1 Plasmodium vivax Vir protein SPX PF03105.19 CDI79437.1 - 0.0049 16.8 15.5 0.0049 16.8 15.5 4.1 3 2 0 3 3 3 1 SPX domain 2OG-FeII_Oxy_2 PF13532.6 CDI79438.1 - 0.0022 18.2 0.1 0.025 14.8 0.1 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Virul_Fac PF10139.9 CDI79438.1 - 0.096 10.9 0.3 0.12 10.6 0.3 1.0 1 0 0 1 1 1 0 Putative bacterial virulence factor DUF1631 PF07793.11 CDI79438.1 - 1.9 6.8 6.6 2.6 6.3 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Med3 PF11593.8 CDI79438.1 - 3.1 6.9 10.2 4.1 6.5 10.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF1180 PF06679.12 CDI79438.1 - 6.5 7.1 8.6 9.4 6.6 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RNB PF00773.19 CDI79440.1 - 2.2e-32 112.7 6.3 1e-16 61.2 0.0 3.5 2 2 1 3 3 3 3 RNB domain Ribosomal_60s PF00428.19 CDI79440.1 - 4 8.1 30.8 0.46 11.1 9.4 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein Med15 PF09606.10 CDI79440.1 - 8.2 5.0 31.7 15 4.2 31.7 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4834 PF16118.5 CDI79440.1 - 8.9 7.3 11.4 4.2 8.4 2.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) RskA PF10099.9 CDI79441.1 - 3.2e-05 24.3 2.0 3.2e-05 24.3 2.0 4.4 2 1 1 3 3 2 2 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI79441.1 - 0.00044 19.9 10.8 0.00044 19.9 10.8 4.0 2 1 2 4 4 3 1 Nuclear RNA-splicing-associated protein Activator_LAG-3 PF11498.8 CDI79441.1 - 0.0057 15.7 59.0 0.086 11.8 20.0 2.4 2 0 0 2 2 2 2 Transcriptional activator LAG-3 Cwf_Cwc_15 PF04889.12 CDI79441.1 - 0.029 14.1 19.7 0.15 11.7 10.4 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CNDH2_C PF16858.5 CDI79441.1 - 0.034 14.0 19.9 0.14 12.1 7.9 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Caldesmon PF02029.15 CDI79441.1 - 0.047 12.5 22.5 0.0097 14.7 4.3 2.2 2 0 0 2 2 2 0 Caldesmon Pinin_SDK_memA PF04696.13 CDI79441.1 - 0.12 12.4 34.1 0.89 9.6 17.4 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region MMR1 PF08505.10 CDI79441.1 - 0.15 12.4 37.5 0.12 12.7 16.0 2.4 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Tetraspanin PF00335.20 CDI79441.1 - 0.17 11.6 2.3 0.24 11.1 2.3 1.2 1 0 0 1 1 1 0 Tetraspanin family Spt20 PF12090.8 CDI79441.1 - 0.19 11.3 69.7 1 9.0 37.5 2.6 2 0 0 2 2 2 0 Spt20 family MRP-S31 PF15433.6 CDI79441.1 - 0.21 11.3 18.6 0.39 10.3 7.3 2.4 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Connexin PF00029.19 CDI79441.1 - 0.21 11.3 15.7 0.97 9.1 7.6 2.3 2 0 0 2 2 2 0 Connexin MAT1 PF06391.13 CDI79441.1 - 0.23 11.3 24.3 0.34 10.7 11.5 2.4 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 eIF-3_zeta PF05091.12 CDI79441.1 - 0.49 9.3 30.6 0.51 9.3 5.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SAGA-Tad1 PF12767.7 CDI79441.1 - 0.89 9.2 22.5 1.3 8.7 9.8 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF4770 PF15994.5 CDI79441.1 - 0.98 9.6 24.7 3.2 8.0 12.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF2072 PF09845.9 CDI79441.1 - 1.1 9.6 16.3 3.3 8.0 0.9 2.4 2 0 0 2 2 2 0 Zn-ribbon containing protein FmiP_Thoc5 PF09766.9 CDI79441.1 - 1.1 8.4 28.7 0.3 10.3 13.2 2.1 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 RR_TM4-6 PF06459.12 CDI79441.1 - 1.8 8.3 28.7 4 7.2 5.0 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI79441.1 - 2.1 6.6 11.4 5.1 5.4 6.3 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 MecA PF05389.12 CDI79441.1 - 2.8 7.5 19.6 4.2 6.9 2.0 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) SLC12 PF03522.15 CDI79441.1 - 2.8 6.9 27.0 2.3 7.2 13.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 CLN3 PF02487.17 CDI79441.1 - 3.1 6.8 22.1 0.78 8.7 2.2 2.2 2 0 0 2 2 2 0 CLN3 protein Nop53 PF07767.11 CDI79441.1 - 3.7 6.9 31.1 0.21 11.0 4.3 2.3 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) XAP5 PF04921.14 CDI79441.1 - 3.8 7.3 19.6 5 6.9 7.3 2.4 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF719 PF05334.13 CDI79441.1 - 4.3 7.5 26.4 2.1 8.5 11.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF719) SpoIIP PF07454.11 CDI79441.1 - 4.3 6.7 29.4 0.95 8.9 15.1 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF5523 PF17661.1 CDI79441.1 - 4.6 6.9 26.1 6.1 6.4 12.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF4638 PF15472.6 CDI79441.1 - 5.1 6.8 20.3 0.93 9.2 9.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) FHIPEP PF00771.20 CDI79441.1 - 5.8 5.3 18.1 0.8 8.1 7.6 2.4 2 0 0 2 2 2 0 FHIPEP family AAA_23 PF13476.6 CDI79441.1 - 6.1 7.3 22.5 0.86 10.1 0.2 2.2 2 0 0 2 2 2 0 AAA domain DNA_pol_delta_4 PF04081.13 CDI79441.1 - 9 6.6 19.3 25 5.2 1.5 2.8 3 0 0 3 3 3 0 DNA polymerase delta, subunit 4 EIIBC-GUT_N PF03612.14 CDI79441.1 - 9 6.0 26.3 4.1 7.1 4.3 2.7 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus PA26 PF04636.13 CDI79441.1 - 9.1 5.1 23.8 5.9 5.7 5.6 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Peptidase_S64 PF08192.11 CDI79441.1 - 9.5 4.6 37.0 1.8 7.0 9.9 2.1 2 0 0 2 2 2 0 Peptidase family S64 ASD2 PF08687.11 CDI79441.1 - 9.6 5.7 28.6 4.1 6.9 7.4 2.4 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 RskA PF10099.9 CDI79443.1 - 9.9e-05 22.7 1.8 9.9e-05 22.7 1.8 8.9 2 2 4 6 6 6 3 Anti-sigma-K factor rskA AbrB PF05145.12 CDI79443.1 - 0.06 12.3 0.1 0.06 12.3 0.1 3.0 4 0 0 4 4 4 0 Transition state regulatory protein AbrB Apt1 PF10351.9 CDI79444.1 - 0.16 10.8 14.1 0.21 10.4 14.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI79444.1 - 1.4 7.3 9.3 1.8 6.9 9.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF2681 PF10883.8 CDI79444.1 - 1.9 9.0 8.7 0.21 12.0 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) SUIM_assoc PF16619.5 CDI79444.1 - 9.5 6.4 18.8 3.6 7.7 12.9 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 tRNA_bind PF01588.20 CDI79446.1 - 4.2e-23 81.3 0.0 9.2e-23 80.2 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.6 CDI79446.1 - 1.2e-06 28.6 0.0 3.2e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDI79446.1 - 0.00028 21.1 1.4 0.00083 19.5 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDI79446.1 - 0.00097 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Spt20 PF12090.8 CDI79446.1 - 0.0034 17.0 10.1 0.0052 16.4 10.1 1.2 1 0 0 1 1 1 1 Spt20 family FTZ PF03867.14 CDI79446.1 - 0.0036 16.9 3.1 0.0061 16.1 3.1 1.3 1 0 0 1 1 1 1 Fushi tarazu (FTZ), N-terminal region EPL1 PF10513.9 CDI79446.1 - 0.023 15.1 1.2 0.12 12.8 1.2 1.9 2 0 0 2 2 2 0 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CDI79446.1 - 0.044 12.8 4.6 0.054 12.5 4.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Mss4 PF04421.13 CDI79446.1 - 0.13 12.5 1.2 1.4 9.1 1.2 2.3 1 1 0 1 1 1 0 Mss4 protein FAM176 PF14851.6 CDI79446.1 - 0.14 11.8 1.3 0.26 10.9 1.3 1.4 1 0 0 1 1 1 0 FAM176 family RIFIN PF02009.16 CDI79446.1 - 0.29 11.0 3.9 0.41 10.5 3.9 1.2 1 0 0 1 1 1 0 Rifin Presenilin PF01080.17 CDI79446.1 - 0.88 8.3 5.2 1.2 7.9 5.2 1.2 1 0 0 1 1 1 0 Presenilin PRAP PF15314.6 CDI79446.1 - 0.89 10.1 5.3 28 5.3 0.0 3.1 3 0 0 3 3 3 0 Proline-rich acidic protein 1, pregnancy-specific uterine TraV PF09676.10 CDI79446.1 - 1.1 10.3 10.3 1.9 9.5 10.3 1.4 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) NARP1 PF12569.8 CDI79446.1 - 1.4 7.7 9.0 1.9 7.3 9.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.12 CDI79446.1 - 4.3 7.1 8.3 6.3 6.5 8.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ANAPC_CDC26 PF10471.9 CDI79446.1 - 8.7 7.3 16.2 19 6.2 16.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Prominin PF05478.11 CDI79447.1 - 1.7 6.5 11.6 3.1 5.6 11.6 1.3 1 0 0 1 1 1 0 Prominin Allexi_40kDa PF05549.11 CDI79447.1 - 7.3 6.0 10.6 5 6.6 8.6 1.8 1 1 0 1 1 1 0 Allexivirus 40kDa protein Hydrolase_4 PF12146.8 CDI79448.1 - 1.3e-15 57.4 0.2 3.3e-15 56.0 0.2 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDI79448.1 - 4e-08 34.1 0.0 5.3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDI79448.1 - 2.5e-07 30.4 0.0 0.00031 20.3 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CDI79448.1 - 5.1e-07 29.8 0.0 1e-06 28.7 0.0 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 CDI79448.1 - 5.6e-07 28.5 0.1 2.7e-05 23.0 0.0 2.5 3 0 0 3 3 3 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CDI79448.1 - 9.2e-07 28.6 0.0 0.00063 19.4 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CDI79448.1 - 1.5e-06 28.1 0.0 0.00098 18.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CDI79448.1 - 6.7e-06 25.9 0.0 9.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Lipase_3 PF01764.25 CDI79448.1 - 0.0021 17.9 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) FSH1 PF03959.13 CDI79448.1 - 0.0046 16.7 0.0 0.051 13.2 0.0 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 CDI79448.1 - 0.0089 16.0 0.1 1.8 8.4 0.0 2.2 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIP PF03583.14 CDI79448.1 - 0.0094 15.3 0.1 0.61 9.4 0.0 2.1 2 0 0 2 2 2 1 Secretory lipase DEAD PF00270.29 CDI79449.1 - 1.2e-14 54.4 0.0 7.3e-14 51.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDI79449.1 - 1.4e-08 35.0 0.2 1e-06 28.8 0.0 3.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SR-25 PF10500.9 CDI79449.1 - 0.0019 17.8 4.3 0.0019 17.8 4.3 5.1 4 2 1 5 5 5 1 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDI79449.1 - 0.65 10.3 27.9 0.48 10.7 2.9 4.4 4 0 0 4 4 4 0 Early growth response N-terminal domain RskA PF10099.9 CDI79449.1 - 5.8 7.2 35.7 0.23 11.7 0.5 5.5 6 1 0 6 6 6 0 Anti-sigma-K factor rskA Flagellar_rod PF05149.12 CDI79450.1 - 0.068 12.6 9.5 0.19 11.1 9.5 1.7 1 1 0 1 1 1 0 Paraflagellar rod protein DUF2203 PF09969.9 CDI79450.1 - 0.31 11.8 17.6 0.81 10.4 1.2 3.9 2 2 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) DUF3123 PF11321.8 CDI79450.1 - 0.41 11.3 0.1 0.41 11.3 0.1 4.1 3 1 0 4 4 4 0 Protein of unknown function (DUF3123) JIP_LZII PF16471.5 CDI79450.1 - 2.8 8.2 5.3 1.2 9.3 0.3 2.7 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II OmpH PF03938.14 CDI79450.1 - 9.4 6.6 23.0 3 8.2 10.4 3.3 2 1 2 4 4 4 0 Outer membrane protein (OmpH-like) AAA_11 PF13086.6 CDI79451.1 - 6.3e-61 206.4 5.0 6.3e-61 206.4 5.0 4.2 3 2 0 3 3 2 1 AAA domain AAA_12 PF13087.6 CDI79451.1 - 2.2e-55 187.4 0.0 6.4e-55 185.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDI79451.1 - 2.1e-07 31.4 0.1 1.3e-06 28.9 0.1 2.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDI79451.1 - 1.5e-05 24.8 9.9 0.77 9.4 0.0 4.8 5 0 0 5 5 5 3 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CDI79451.1 - 0.00063 19.8 0.0 0.0041 17.1 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDI79451.1 - 0.0012 19.2 0.5 0.0067 16.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CDI79451.1 - 0.0026 18.2 0.5 0.041 14.3 0.0 3.2 4 0 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) DUF4667 PF15700.5 CDI79451.1 - 0.004 17.3 3.3 0.004 17.3 3.3 4.5 4 2 0 4 4 1 1 Domain of unknown function (DUF4667) AAA_24 PF13479.6 CDI79451.1 - 0.0065 16.2 2.1 3.2 7.4 0.0 3.6 2 1 1 3 3 3 1 AAA domain CbiA PF01656.23 CDI79451.1 - 0.015 15.4 1.7 0.028 14.5 0.1 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain UvrD_C_2 PF13538.6 CDI79451.1 - 0.038 13.8 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_18 PF13238.6 CDI79451.1 - 0.17 12.5 0.4 1.2 9.6 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 CDI79451.1 - 0.28 11.3 6.7 0.34 11.1 2.8 3.3 2 1 0 2 2 2 0 AAA domain Tau95_N PF17682.1 CDI79451.1 - 0.84 9.8 0.0 0.84 9.8 0.0 4.5 4 1 0 4 4 3 0 Tau95 Triple barrel domain Nckap1 PF09735.9 CDI79451.1 - 6.2 4.6 7.0 10 3.9 7.0 1.2 1 0 0 1 1 1 0 Membrane-associated apoptosis protein SRP54 PF00448.22 CDI79452.1 - 5.5e-45 153.4 0.1 1.2e-44 152.3 0.1 1.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain B12-binding PF02310.19 CDI79452.1 - 0.05 13.7 0.0 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 B12 binding domain LRR_8 PF13855.6 CDI79454.1 - 0.00015 21.4 3.3 0.00067 19.4 0.9 2.5 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 CDI79454.1 - 0.0027 18.1 5.0 0.023 15.1 3.3 2.5 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) NST1 PF13945.6 CDI79455.1 - 0.022 14.9 15.3 0.025 14.7 15.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Spt20 PF12090.8 CDI79455.1 - 0.06 13.0 22.5 0.069 12.7 22.5 1.2 1 0 0 1 1 1 0 Spt20 family Acetyltransf_2 PF00797.17 CDI79455.1 - 0.062 13.1 2.6 0.062 13.1 2.6 1.1 1 0 0 1 1 1 0 N-acetyltransferase Hist_deacetyl PF00850.19 CDI79455.1 - 0.43 10.0 4.8 0.49 9.8 4.8 1.1 1 0 0 1 1 1 0 Histone deacetylase domain HD-ZIP_N PF04618.12 CDI79455.1 - 0.97 10.0 6.0 1.2 9.6 5.7 1.3 1 1 0 1 1 1 0 HD-ZIP protein N terminus TFIIA PF03153.13 CDI79455.1 - 1.1 9.1 26.4 1.4 8.9 26.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 CDI79455.1 - 1.6 8.1 9.6 1.8 7.9 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF572 PF04502.13 CDI79455.1 - 4.5 6.8 17.2 5.3 6.6 17.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) PCM1_C PF15717.5 CDI79455.1 - 8.3 5.0 16.1 9.1 4.8 16.1 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus SAGA-Tad1 PF12767.7 CDI79455.1 - 8.5 6.0 12.7 9.6 5.9 12.7 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF3807 PF12720.7 CDI79455.1 - 9.9 6.4 20.7 15 5.8 20.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SNF2_N PF00176.23 CDI79456.1 - 0.043 12.5 0.0 0.043 12.5 0.0 3.6 3 1 0 3 3 3 0 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI79457.1 - 3.3e-09 37.1 0.0 9.2e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2722 PF10846.8 CDI79460.1 - 0.012 14.6 3.5 0.025 13.5 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Phostensin_N PF13916.6 CDI79460.1 - 0.031 14.6 1.4 0.031 14.6 1.4 2.8 3 0 0 3 3 3 0 PP1-regulatory protein, Phostensin N-terminal WBP-1 PF11669.8 CDI79460.1 - 0.36 11.5 4.4 3.1 8.5 0.0 2.9 3 0 0 3 3 3 0 WW domain-binding protein 1 EphA2_TM PF14575.6 CDI79460.1 - 0.74 10.7 6.9 55 4.7 0.0 3.8 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Gaa1 PF04114.14 CDI79460.1 - 1.9 7.4 10.6 3.5 6.5 3.0 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component Sarcoglycan_2 PF05510.13 CDI79460.1 - 5.5 5.6 5.6 2.4 6.8 2.4 1.8 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon Cas_Cas7 PF05107.12 CDI79462.1 - 0.15 11.6 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 CRISPR-associated protein Cas7 DUF3843 PF12954.7 CDI79462.1 - 0.73 8.7 6.9 1 8.3 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3843) TFIIA PF03153.13 CDI79462.1 - 1.5 8.7 39.4 3.6 7.5 39.4 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI79462.1 - 3.9 6.1 7.9 6.5 5.4 7.9 1.3 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI79462.1 - 4.4 7.3 7.4 7.3 6.6 7.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PseudoU_synth_2 PF00849.22 CDI79464.1 - 8.7e-18 64.9 1.5 8.7e-18 64.9 1.5 3.7 4 0 0 4 4 4 1 RNA pseudouridylate synthase RrnaAD PF00398.20 CDI79464.1 - 2.3e-17 63.0 0.0 1.2e-15 57.3 0.0 2.5 1 1 1 2 2 2 1 Ribosomal RNA adenine dimethylase Utp14 PF04615.13 CDI79464.1 - 1.2e-06 27.4 12.4 1.2e-06 27.4 12.4 4.5 3 2 0 4 4 4 1 Utp14 protein Otopetrin PF03189.13 CDI79464.1 - 2.2e-06 26.8 20.4 0.37 9.6 0.0 5.0 3 1 1 4 4 4 3 Otopetrin DUF572 PF04502.13 CDI79464.1 - 0.0033 17.1 26.6 0.0033 17.1 26.6 5.0 3 1 1 4 4 4 1 Family of unknown function (DUF572) SpoIIIAH PF12685.7 CDI79464.1 - 0.01 15.7 0.9 0.01 15.7 0.9 7.1 4 2 0 4 4 4 0 SpoIIIAH-like protein Methyltransf_25 PF13649.6 CDI79464.1 - 0.035 14.8 0.1 0.41 11.4 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDI79464.1 - 0.038 13.8 0.0 0.038 13.8 0.0 6.8 6 3 0 7 7 7 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDI79464.1 - 0.064 13.9 0.0 0.78 10.4 0.0 3.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDI79464.1 - 5.4 7.8 0.0 5.4 7.8 0.0 5.5 8 1 0 8 8 8 0 Methyltransferase domain Thioredoxin_11 PF18078.1 CDI79467.1 - 0.076 13.1 0.7 0.076 13.1 0.7 2.4 3 0 0 3 3 3 0 Thioredoxin-like SNTX domain O-antigen_lig PF13425.6 CDI79467.1 - 4.4 6.0 4.2 21 3.7 4.2 1.8 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Peptidase_M1 PF01433.20 CDI79468.1 - 2.3e-12 46.9 0.0 3.2e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3336 PF11815.8 CDI79469.1 - 3.1e-09 36.7 0.2 3.1e-09 36.7 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Spt20 PF12090.8 CDI79469.1 - 7.7e-05 22.4 35.6 0.0009 18.9 0.8 2.8 2 0 0 2 2 2 2 Spt20 family Sporozoite_P67 PF05642.11 CDI79469.1 - 0.011 13.9 9.3 0.016 13.3 9.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2722 PF10846.8 CDI79469.1 - 0.022 13.7 0.3 0.022 13.7 0.3 2.5 2 1 0 2 2 1 0 Protein of unknown function (DUF2722) RLL PF10036.9 CDI79469.1 - 0.084 12.7 22.4 0.045 13.6 1.4 2.7 3 0 0 3 3 3 0 RNA transcription, translation and transport factor protein DUF4834 PF16118.5 CDI79469.1 - 0.12 13.3 0.1 0.12 13.3 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 CDI79469.1 - 0.14 11.2 0.0 0.14 11.2 0.0 2.2 2 0 0 2 2 2 0 CLN3 protein Connexin PF00029.19 CDI79469.1 - 2.5 7.8 9.6 16 5.1 0.0 2.4 2 0 0 2 2 2 0 Connexin Spore_YhcN_YlaJ PF09580.10 CDI79469.1 - 3.4 7.7 12.7 3.4 7.7 0.0 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Presenilin PF01080.17 CDI79469.1 - 4.2 6.0 18.9 5.8 5.6 0.1 2.4 2 0 0 2 2 2 0 Presenilin eIF-3_zeta PF05091.12 CDI79469.1 - 7 5.5 21.0 1.5 7.7 0.2 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) WBP-1 PF11669.8 CDI79469.1 - 8.1 7.1 14.4 0.64 10.7 0.4 2.7 2 0 0 2 2 2 0 WW domain-binding protein 1 Folate_carrier PF01770.18 CDI79469.1 - 8.6 5.0 8.6 6.8 5.3 0.0 2.3 2 0 0 2 2 2 0 Reduced folate carrier DALR_1 PF05746.15 CDI79471.1 - 1.2e-10 41.6 5.0 1.3e-10 41.4 0.1 3.3 2 1 0 2 2 2 1 DALR anticodon binding domain SR-25 PF10500.9 CDI79471.1 - 1.5e-05 24.7 12.7 1.5e-05 24.7 12.7 10.2 6 3 2 8 8 8 2 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI79471.1 - 2.4e-05 24.1 14.6 2.4e-05 24.1 14.6 9.5 6 3 1 7 7 7 3 Spt20 family tRNA-synt_1d PF00750.19 CDI79471.1 - 0.0023 16.9 3.9 0.0039 16.2 0.1 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (R) RskA PF10099.9 CDI79471.1 - 0.008 16.5 5.0 0.008 16.5 5.0 6.3 5 1 0 5 5 5 3 Anti-sigma-K factor rskA Caldesmon PF02029.15 CDI79471.1 - 0.044 12.6 0.0 0.044 12.6 0.0 5.7 4 1 0 6 6 6 0 Caldesmon PAP_assoc PF03828.19 CDI79474.1 - 3e-05 24.1 0.0 9.1e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDI79474.1 - 0.019 15.3 0.1 0.039 14.2 0.1 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF1676 PF07898.13 CDI79474.1 - 3.2 7.7 0.0 3.2 7.7 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1676) RskA PF10099.9 CDI79475.1 - 6e-05 23.4 10.1 6e-05 23.4 10.1 6.5 2 2 3 5 5 5 3 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI79475.1 - 0.023 15.4 6.7 0.023 15.4 6.7 6.4 2 1 4 6 6 6 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 CDI79475.1 - 0.49 11.4 0.1 0.49 11.4 0.1 6.8 3 1 1 5 5 5 0 Domain of unknown function (DUF4834) Peptidase_C1 PF00112.23 CDI79476.1 - 4.2e-63 213.3 26.7 1e-51 176.1 4.9 2.7 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 CDI79476.1 - 3e-10 40.4 0.2 6.7e-10 39.3 0.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ndc1_Nup PF09531.10 CDI79476.1 - 0.19 10.4 15.1 0.36 9.5 15.1 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 CDI79476.1 - 0.29 9.9 18.4 0.46 9.2 18.4 1.2 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 CDI79476.1 - 0.64 7.9 16.6 0.86 7.4 16.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI79476.1 - 0.82 7.9 37.2 1.2 7.4 37.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ASC PF00858.24 CDI79476.1 - 2 7.3 17.3 4.1 6.3 17.3 1.5 1 1 0 1 1 1 0 Amiloride-sensitive sodium channel SID-1_RNA_chan PF13965.6 CDI79476.1 - 3.8 5.8 5.9 6.2 5.1 5.9 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI79476.1 - 3.9 6.4 22.1 6.5 5.7 22.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 CDI79476.1 - 9.1 6.2 14.1 22 4.9 14.1 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Arm_3 PF16186.5 CDI79477.1 - 0.00046 19.7 0.0 0.00077 19.0 0.0 1.3 1 0 0 1 1 1 1 Atypical Arm repeat PT PF04886.12 CDI79479.1 - 5.6e-05 22.6 33.1 0.08 12.5 15.7 5.0 1 1 3 4 4 4 3 PT repeat Cyclase_polyket PF04673.12 CDI79480.1 - 0.099 12.9 0.6 0.32 11.3 0.6 1.9 1 0 0 1 1 1 0 Polyketide synthesis cyclase UPF0160 PF03690.13 CDI79481.1 - 5.8e-66 223.3 5.4 4.9e-29 102.0 0.2 4.3 3 2 1 4 4 4 4 Uncharacterised protein family (UPF0160) CENP-F_leu_zip PF10473.9 CDI79481.1 - 0.076 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TFIIA PF03153.13 CDI79482.1 - 0.00019 21.6 33.8 0.00019 21.6 33.8 4.3 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit PRCC PF10253.9 CDI79482.1 - 0.011 16.5 21.6 0.011 16.5 21.6 4.1 3 1 2 5 5 5 0 Mitotic checkpoint regulator, MAD2B-interacting AAA_23 PF13476.6 CDI79482.1 - 1.2 9.5 29.1 0.92 10.0 10.6 2.3 2 0 0 2 2 2 0 AAA domain CGI-121 PF08617.10 CDI79483.1 - 3.3e-15 56.6 6.2 1.9e-11 44.4 0.1 3.4 3 1 0 3 3 3 2 Kinase binding protein CGI-121 TFIIA PF03153.13 CDI79483.1 - 5.4e-06 26.7 25.7 5e-05 23.5 14.0 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 CDI79483.1 - 0.00064 18.7 7.7 0.00064 18.7 7.7 3.4 3 0 0 3 3 3 1 Androgen receptor NPR3 PF03666.13 CDI79483.1 - 0.00099 18.0 1.7 0.00099 18.0 1.7 2.0 3 0 0 3 3 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Miga PF10265.9 CDI79483.1 - 0.0016 17.5 7.0 0.0016 17.5 7.0 2.9 3 0 0 3 3 3 1 Mitoguardin Apt1 PF10351.9 CDI79483.1 - 0.0032 16.4 4.8 0.0032 16.4 4.8 2.5 3 0 0 3 3 3 1 Golgi-body localisation protein domain EPL1 PF10513.9 CDI79483.1 - 0.0037 17.7 2.8 0.0037 17.7 2.8 2.7 3 0 0 3 3 3 1 Enhancer of polycomb-like Band_3_cyto PF07565.13 CDI79483.1 - 0.076 12.8 9.5 0.039 13.8 4.1 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Spt20 PF12090.8 CDI79483.1 - 0.096 12.3 43.0 0.021 14.5 29.3 2.4 2 0 0 2 2 2 0 Spt20 family LicD PF04991.13 CDI79483.1 - 0.16 12.0 2.6 0.09 12.9 0.6 1.6 2 0 0 2 2 2 0 LicD family Tim54 PF11711.8 CDI79483.1 - 0.27 10.0 7.0 0.03 13.1 2.5 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Activator_LAG-3 PF11498.8 CDI79483.1 - 0.28 10.1 30.0 0.3 10.0 18.5 2.5 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Ribosomal_60s PF00428.19 CDI79483.1 - 0.44 11.2 7.1 0.96 10.1 7.1 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein PepSY_TM PF03929.16 CDI79483.1 - 0.56 9.8 2.3 1.2 8.7 0.2 2.1 2 0 0 2 2 2 0 PepSY-associated TM region BAF1_ABF1 PF04684.13 CDI79483.1 - 1.3 8.0 21.6 0.014 14.5 13.9 1.5 2 1 0 2 2 1 0 BAF1 / ABF1 chromatin reorganising factor Dicty_REP PF05086.12 CDI79483.1 - 4.7 5.1 13.8 7.8 4.3 13.8 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4366 PF14283.6 CDI79483.1 - 6.3 6.8 8.1 6.3 6.8 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF2681 PF10883.8 CDI79483.1 - 7.8 7.0 23.7 13 6.3 2.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) SLC12 PF03522.15 CDI79483.1 - 9.6 5.1 16.8 1.2 8.1 11.3 1.9 2 0 0 2 2 2 0 Solute carrier family 12 Pox_A_type_inc PF04508.12 CDI79487.1 - 0.016 15.0 0.3 0.061 13.2 0.3 2.1 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat TSC22 PF01166.18 CDI79487.1 - 0.037 14.3 0.3 0.11 12.8 0.3 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF2229 PF09989.9 CDI79487.1 - 1.7 8.3 4.1 3.5 7.2 4.1 1.5 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) CbiG_C PF01890.16 CDI79487.1 - 1.9 9.0 7.7 0.35 11.4 1.8 2.7 3 0 0 3 3 3 0 Cobalamin synthesis G C-terminus Porin_4 PF13609.6 CDI79488.1 - 0.024 14.4 0.2 0.032 14.0 0.2 1.2 1 0 0 1 1 1 0 Gram-negative porin Topoisom_bac PF01131.20 CDI79489.1 - 4.4e-24 85.3 0.2 7.1e-16 58.2 0.0 4.5 3 2 1 4 4 4 3 DNA topoisomerase Toprim PF01751.22 CDI79489.1 - 2.1e-07 31.1 0.0 4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Toprim domain Toprim_4 PF13662.6 CDI79489.1 - 0.06 13.8 0.0 0.22 12.0 0.0 2.0 2 0 0 2 2 2 0 Toprim domain Pkinase PF00069.25 CDI79490.1 - 2.9e-37 128.5 0.0 4.3e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79490.1 - 3.1e-20 72.6 0.0 4.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 CDI79490.1 - 7.7e-11 42.3 0.8 8.5e-06 26.1 0.0 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI79490.1 - 1.3e-08 34.1 1.4 0.0026 17.6 0.1 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 CDI79490.1 - 4.6e-08 32.8 2.5 7e-05 22.6 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI79490.1 - 8.5e-08 31.2 2.8 0.0028 17.1 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 CDI79490.1 - 1.2e-06 27.7 5.4 0.006 16.0 0.5 2.9 3 0 0 3 3 3 2 EF hand Kinase-like PF14531.6 CDI79490.1 - 1.7e-05 24.3 0.0 5.8e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like DUF1811 PF08838.10 CDI79493.1 - 1.3 9.3 3.2 0.57 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) Dcc1 PF09724.9 CDI79494.1 - 5.7e-12 45.6 0.5 6.2e-07 29.0 0.1 2.3 2 0 0 2 2 2 2 Sister chromatid cohesion protein Dcc1 Ctf8 PF09696.10 CDI79494.1 - 0.015 15.6 0.1 0.29 11.5 0.0 2.8 3 0 0 3 3 3 0 Ctf8 FAD_binding_3 PF01494.19 CDI79495.1 - 8.2e-25 87.8 8.6 3.1e-17 62.9 0.0 4.5 5 0 0 5 5 5 2 FAD binding domain Lycopene_cycl PF05834.12 CDI79495.1 - 3.8e-05 22.9 0.1 3.8e-05 22.9 0.1 3.1 4 0 0 4 4 4 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CDI79495.1 - 0.0012 19.1 1.1 0.0046 17.1 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDI79495.1 - 0.0012 18.5 0.0 0.0012 18.5 0.0 2.8 3 1 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDI79495.1 - 0.003 16.8 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDI79495.1 - 0.0044 16.3 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CDI79495.1 - 0.0076 15.0 1.7 0.011 14.4 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDI79495.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_1 PF00561.20 CDI79497.1 - 0.0089 15.7 0.0 0.0089 15.7 0.0 5.5 5 0 0 5 5 5 2 alpha/beta hydrolase fold Tex_YqgF PF16921.5 CDI79500.1 - 0.028 14.9 1.2 1.6 9.2 0.1 2.7 2 0 0 2 2 2 0 Tex protein YqgF-like domain UPF0564 PF10595.9 CDI79500.1 - 5.7 5.9 41.4 2.7 7.0 23.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 DUF2722 PF10846.8 CDI79501.1 - 0.00023 20.2 1.3 0.00032 19.8 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Nucleoporin_N PF08801.11 CDI79501.1 - 0.0046 15.8 0.0 0.011 14.6 0.0 1.5 1 1 0 1 1 1 1 Nup133 N terminal like TFIIA PF03153.13 CDI79501.1 - 0.045 13.8 7.2 0.068 13.2 7.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI79501.1 - 0.1 11.3 11.6 0.15 10.7 11.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CPSF73-100_C PF11718.8 CDI79501.1 - 0.12 11.9 0.2 0.17 11.4 0.2 1.2 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Sporozoite_P67 PF05642.11 CDI79501.1 - 0.23 9.5 4.6 0.31 9.1 4.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SelP_N PF04592.14 CDI79501.1 - 1.1 8.6 10.5 1.7 8.0 10.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1645 PF07816.11 CDI79501.1 - 1.4 9.5 11.1 3.9 8.0 10.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) DivIC PF04977.15 CDI79501.1 - 2.5 7.9 7.1 4.4 7.1 7.1 1.3 1 0 0 1 1 1 0 Septum formation initiator Spt20 PF12090.8 CDI79501.1 - 3.4 7.2 16.9 5.3 6.6 16.9 1.2 1 0 0 1 1 1 0 Spt20 family Di19_C PF14571.6 CDI79501.1 - 6.7 7.3 10.2 3.6 8.2 1.7 2.4 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal TPR_1 PF00515.28 CDI79502.1 - 2.5e-06 27.1 2.6 0.033 14.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI79502.1 - 6e-06 26.0 3.4 0.018 15.1 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDI79502.1 - 0.0026 18.2 0.1 0.0026 18.2 0.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI79502.1 - 0.0057 16.8 3.3 2.7 8.4 0.1 3.3 4 0 0 4 4 3 2 Tetratricopeptide repeat MIT PF04212.18 CDI79502.1 - 0.01 15.9 5.4 0.27 11.3 0.1 3.6 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 CDI79502.1 - 0.028 14.7 5.0 0.42 10.9 0.6 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI79502.1 - 0.031 14.0 2.3 0.77 9.5 0.2 3.1 2 1 0 2 2 2 0 TPR repeat TPR_7 PF13176.6 CDI79502.1 - 0.075 13.1 0.7 0.33 11.1 0.1 2.5 2 0 0 2 2 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI79502.1 - 0.089 13.0 1.4 0.38 11.0 0.3 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CDI79502.1 - 0.19 12.4 2.4 0.43 11.3 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat IMUP PF15761.5 CDI79502.1 - 0.58 10.9 6.2 1.7 9.3 6.2 1.8 1 0 0 1 1 1 0 Immortalisation up-regulated protein TPR_14 PF13428.6 CDI79502.1 - 0.76 10.8 5.8 4.1 8.5 0.2 4.0 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDI79502.1 - 1.2 9.9 8.5 11 6.9 0.1 4.2 4 1 0 4 4 3 0 Tetratricopeptide repeat Acyl-CoA_dh_1 PF00441.24 CDI79504.1 - 1e-15 58.2 0.1 1.1e-14 54.9 0.1 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF45 PF01863.17 CDI79505.1 - 0.015 15.4 4.2 0.026 14.6 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 DUF4411 PF14367.6 CDI79505.1 - 0.024 14.5 4.8 0.049 13.5 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Hamartin PF04388.12 CDI79505.1 - 0.027 13.1 20.1 0.044 12.5 20.1 1.3 1 0 0 1 1 1 0 Hamartin protein DUF1454 PF07305.12 CDI79505.1 - 0.19 11.1 4.1 0.38 10.2 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) His_Phos_1 PF00300.22 CDI79505.1 - 0.27 10.9 18.0 0.32 10.7 5.1 4.2 2 1 1 3 3 3 0 Histidine phosphatase superfamily (branch 1) TFIIA PF03153.13 CDI79505.1 - 0.49 10.3 35.9 0.034 14.2 27.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI79505.1 - 4.5 5.7 28.1 11 4.5 28.2 1.6 1 1 0 1 1 1 0 Macoilin family AAA_12 PF13087.6 CDI79506.1 - 3.7e-47 160.5 0.1 3.7e-47 160.5 0.1 6.1 8 0 0 8 8 8 2 AAA domain AAA_11 PF13086.6 CDI79506.1 - 8.8e-36 124.0 16.1 3.1e-20 73.1 15.8 14.7 11 4 1 12 12 12 2 AAA domain PTH2 PF01981.16 CDI79508.1 - 2.6e-16 60.0 7.1 4.9e-14 52.6 2.8 4.7 2 2 1 3 3 3 2 Peptidyl-tRNA hydrolase PTH2 Pex14_N PF04695.13 CDI79510.1 - 0.029 15.0 9.2 0.029 15.0 9.2 3.4 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI79510.1 - 0.064 13.3 52.4 0.68 9.9 21.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI79510.1 - 0.66 8.2 30.9 0.1 10.9 7.6 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RskA PF10099.9 CDI79510.1 - 1.2 9.4 51.7 0.037 14.3 3.8 5.2 1 1 3 4 4 4 0 Anti-sigma-K factor rskA DUF719 PF05334.13 CDI79510.1 - 3.7 7.7 16.0 0.41 10.8 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF719) MecA PF05389.12 CDI79510.1 - 7.6 6.1 12.4 1.4 8.5 2.8 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) TF_Zn_Ribbon PF08271.12 CDI79511.1 - 6e-07 28.9 0.2 6e-07 28.9 0.2 2.1 2 0 0 2 2 2 1 TFIIB zinc-binding TFIIB PF00382.19 CDI79511.1 - 2.5e-06 27.4 0.1 7.1e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 Transcription factor TFIIB repeat TFIIS_M PF07500.14 CDI79512.1 - 6.1e-25 87.9 0.3 9.9e-25 87.2 0.3 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CDI79512.1 - 6.8e-19 67.4 5.1 1.3e-18 66.6 5.1 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 CDI79512.1 - 2.7e-11 43.3 0.4 6.1e-11 42.2 0.4 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Macoilin PF09726.9 CDI79512.1 - 0.023 13.3 4.9 0.029 12.9 4.6 1.4 1 1 0 1 1 1 0 Macoilin family Elf1 PF05129.13 CDI79512.1 - 0.27 11.3 3.2 0.6 10.2 3.2 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like MMU163 PF17119.5 CDI79512.1 - 0.29 10.2 3.8 0.23 10.6 0.8 2.0 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis AF-4 PF05110.13 CDI79512.1 - 1.3 7.0 16.6 1.7 6.6 16.6 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Band_3_cyto PF07565.13 CDI79512.1 - 4.4 7.0 5.8 21 4.8 5.8 1.9 1 1 0 1 1 1 0 Band 3 cytoplasmic domain Pkinase PF00069.25 CDI79514.1 - 1.8e-51 175.0 0.0 6.8e-40 137.1 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79514.1 - 9.4e-19 67.7 0.0 3.2e-12 46.3 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDI79514.1 - 0.00012 21.5 0.1 0.00041 19.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like DUF4012 PF13196.6 CDI79514.1 - 0.15 12.5 0.4 0.46 11.0 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4012) Chorein_N PF12624.7 CDI79516.1 - 0.0051 16.9 0.0 0.0051 16.9 0.0 6.9 8 0 0 8 8 8 1 N-terminal region of Chorein or VPS13 FAM199X PF15814.5 CDI79517.1 - 9.3 5.2 9.4 9.8 5.1 9.4 1.3 1 0 0 1 1 1 0 Protein family FAM199X DUF2722 PF10846.8 CDI79518.1 - 2.4e-05 23.5 0.2 2.4e-05 23.5 0.2 7.9 6 2 1 7 7 7 3 Protein of unknown function (DUF2722) PRCC PF10253.9 CDI79518.1 - 0.00022 22.1 0.3 0.00022 22.1 0.3 7.8 6 3 1 7 7 7 1 Mitotic checkpoint regulator, MAD2B-interacting SR-25 PF10500.9 CDI79518.1 - 0.0043 16.7 0.8 0.0043 16.7 0.8 8.6 7 1 0 8 8 8 3 Nuclear RNA-splicing-associated protein HEAT PF02985.22 CDI79518.1 - 0.04 14.2 4.4 2.9 8.4 0.0 5.2 3 0 0 3 3 3 0 HEAT repeat RskA PF10099.9 CDI79518.1 - 0.15 12.3 0.1 0.15 12.3 0.1 13.0 8 4 0 9 9 9 0 Anti-sigma-K factor rskA Zip PF02535.22 CDI79518.1 - 0.52 9.5 9.8 7.9 5.6 1.4 4.5 4 0 0 4 4 4 0 ZIP Zinc transporter ORC_WH_C PF18137.1 CDI79518.1 - 4 7.5 35.8 0.4 10.7 0.1 5.6 5 0 0 5 5 5 0 Origin recognition complex winged helix C-terminal TPR_2 PF07719.17 CDI79519.1 - 1e-15 56.5 7.4 0.094 12.9 0.6 7.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDI79519.1 - 9.9e-13 47.6 0.0 4.8e-05 23.0 0.1 4.6 4 0 0 4 4 4 3 TPR repeat TPR_8 PF13181.6 CDI79519.1 - 4.8e-09 35.7 1.0 0.044 14.0 0.1 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI79519.1 - 9.1e-09 34.8 0.2 1.3 9.0 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI79519.1 - 1.3e-08 35.0 48.1 0.03 15.1 0.1 9.1 5 2 4 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDI79519.1 - 7.7e-06 25.9 1.4 2.9 8.5 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDI79519.1 - 1.4e-05 25.3 19.9 0.42 10.9 0.9 5.8 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDI79519.1 - 0.00082 20.0 20.7 0.0036 17.9 13.2 7.5 6 2 3 9 9 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDI79519.1 - 0.0016 18.4 3.6 0.59 10.3 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDI79519.1 - 0.0038 17.3 3.0 0.0038 17.3 3.0 5.5 6 0 0 6 6 4 3 Tetratricopeptide repeat TFIIA PF03153.13 CDI79519.1 - 0.0082 16.2 18.7 0.011 15.7 18.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SWI-SNF_Ssr4 PF08549.10 CDI79519.1 - 0.061 12.0 9.5 0.075 11.7 9.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TPR_19 PF14559.6 CDI79519.1 - 0.12 12.9 0.1 0.12 12.9 0.1 5.6 4 2 1 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDI79519.1 - 0.16 12.6 0.0 0.2 12.4 0.0 6.6 9 0 0 9 9 6 0 Tetratricopeptide repeat RIFIN PF02009.16 CDI79519.1 - 0.33 10.8 9.2 0.65 9.8 9.2 1.4 1 0 0 1 1 1 0 Rifin CCSAP PF15748.5 CDI79519.1 - 0.36 11.0 10.1 0.62 10.2 10.1 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF5427 PF10310.9 CDI79519.1 - 0.36 9.7 14.9 0.58 9.0 14.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SUIM_assoc PF16619.5 CDI79519.1 - 0.87 9.7 20.7 0.092 12.8 6.2 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Suf PF05843.14 CDI79519.1 - 2.5 8.0 0.0 2.5 8.0 0.0 2.7 2 1 0 2 2 1 0 Suppressor of forked protein (Suf) Pkinase_Tyr PF07714.17 CDI79525.1 - 0.0053 16.1 0.0 0.028 13.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 CDI79525.1 - 0.022 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain TPR_6 PF13174.6 CDI79525.1 - 0.21 12.3 0.4 1.1 10.0 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec63 PF02889.16 CDI79527.1 - 5.8e-140 464.8 0.0 8.3e-85 284.0 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CDI79527.1 - 1.1e-36 126.3 4.4 5.2e-25 88.2 0.1 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 CDI79527.1 - 3e-32 111.1 0.5 9.8e-32 109.4 0.5 2.0 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 CDI79527.1 - 4.6e-16 59.3 0.0 3.5e-13 49.9 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDI79527.1 - 1.3e-10 41.6 0.1 0.00011 22.4 0.1 4.0 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDI79527.1 - 0.00052 20.3 0.2 0.081 13.2 0.1 3.4 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CDI79527.1 - 0.12 12.8 0.0 0.6 10.5 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) YL1 PF05764.13 CDI79527.1 - 0.35 11.0 8.0 0.021 14.9 2.0 1.9 2 0 0 2 2 2 0 YL1 nuclear protein NOA36 PF06524.12 CDI79527.1 - 5.4 6.2 6.1 11 5.3 6.1 1.3 1 0 0 1 1 1 0 NOA36 protein LepA_C PF06421.12 CDI79530.1 - 1.7e-41 140.7 0.6 2.8e-41 140.0 0.6 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CDI79530.1 - 2.7e-11 43.3 0.0 1.4e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 Elongation factor G C-terminus Phage_HK97_TLTM PF06120.11 CDI79530.1 - 0.0015 17.8 0.0 0.0022 17.2 0.0 1.1 1 0 0 1 1 1 1 Tail length tape measure protein RF3_C PF16658.5 CDI79530.1 - 0.0039 17.0 0.0 0.0082 16.0 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_II PF14492.6 CDI79530.1 - 0.034 14.2 0.1 0.58 10.3 0.1 2.4 1 1 0 1 1 1 0 Elongation Factor G, domain II DUF667 PF05018.13 CDI79535.1 - 4.7e-31 107.9 0.0 5.7e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Penicil_amidase PF01804.18 CDI79539.1 - 3.1e-88 297.5 0.0 5.2e-50 171.1 0.0 3.6 1 1 2 3 3 3 3 Penicillin amidase zf-U1 PF06220.12 CDI79542.1 - 0.00031 20.5 0.5 0.00076 19.2 0.5 1.7 1 0 0 1 1 1 1 U1 zinc finger WW PF00397.26 CDI79542.1 - 0.095 12.8 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 WW domain Peptidase_M24 PF00557.24 CDI79545.1 - 4.8e-38 131.0 0.0 8.3e-38 130.2 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 CDI79545.1 - 1e-33 116.7 0.0 3.1e-32 111.9 0.0 2.9 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 CDI79545.1 - 1.5e-26 92.2 0.3 6.6e-26 90.2 0.0 2.1 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CDI79545.1 - 6e-19 69.0 0.1 1.8e-13 51.3 0.0 2.9 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain MSP1b PF03429.13 CDI79545.1 - 0.067 11.3 1.8 0.099 10.7 1.8 1.1 1 0 0 1 1 1 0 Major surface protein 1B FXa_inhibition PF14670.6 CDI79547.1 - 0.024 14.9 67.2 0.15 12.3 3.8 8.1 6 1 1 7 7 7 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDI79547.1 - 0.041 13.8 39.7 0.13 12.2 1.5 7.4 6 1 0 6 6 6 0 Complement Clr-like EGF-like EGF_3 PF12947.7 CDI79547.1 - 8.4 6.7 43.7 0.67 10.2 0.1 7.6 7 0 0 7 7 7 0 EGF domain ASH PF15780.5 CDI79549.1 - 2.2e-33 114.4 13.8 5.4e-05 23.3 0.0 14.3 16 0 0 16 16 16 6 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 CDI79549.1 - 5.2e-14 52.2 2.3 12 6.2 0.0 11.5 11 1 1 12 12 12 1 Flagellar-associated PapD-like DUF1573 PF07610.11 CDI79549.1 - 1.2e-10 41.3 0.0 4.1 7.5 0.0 10.7 11 2 0 11 11 11 1 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 CDI79549.1 - 1.1e-06 28.4 4.5 2.3 8.1 0.0 8.2 11 0 0 11 11 11 2 MSP (Major sperm protein) domain MYCBPAP PF14646.6 CDI79549.1 - 0.0001 21.4 0.0 1.3 7.9 0.0 4.0 3 1 1 4 4 4 2 MYCBP-associated protein family FixG_C PF11614.8 CDI79549.1 - 0.00043 20.5 0.0 0.73 10.1 0.0 4.6 5 0 0 5 5 5 1 IG-like fold at C-terminal of FixG, putative oxidoreductase TMEM131_like PF12371.8 CDI79549.1 - 0.0005 20.3 1.2 2.9 8.2 0.0 5.8 5 0 0 5 5 5 1 Transmembrane protein 131-like ATP-synt_C PF00137.21 CDI79550.1 - 6.6e-30 103.3 32.9 3.8e-16 59.2 10.6 2.4 3 0 0 3 3 3 2 ATP synthase subunit C G0-G1_switch_2 PF15103.6 CDI79550.1 - 0.17 12.3 0.1 0.3 11.5 0.1 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 IMCp PF12314.8 CDI79551.1 - 2.7e-24 85.3 22.6 2.7e-24 85.3 22.6 3.8 1 1 2 3 3 3 3 Inner membrane complex protein ParA PF10609.9 CDI79552.1 - 2.1e-66 223.9 0.0 5.5e-45 153.7 0.0 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 CDI79552.1 - 7e-16 58.2 0.0 2.1e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 CDI79552.1 - 1.9e-10 40.9 0.0 3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF971 PF06155.12 CDI79552.1 - 8.4e-07 29.5 0.0 1.8e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) AAA_31 PF13614.6 CDI79552.1 - 9.9e-07 28.8 0.1 1.8e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 CDI79552.1 - 6.9e-06 25.5 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 CDI79552.1 - 0.0046 16.2 0.4 0.2 10.8 0.1 2.3 2 0 0 2 2 2 1 Anion-transporting ATPase VirC1 PF07015.11 CDI79552.1 - 0.0069 15.7 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein APS_kinase PF01583.20 CDI79552.1 - 0.052 13.4 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Fer4_NifH PF00142.18 CDI79552.1 - 0.074 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 CDI79552.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop OTU PF02338.19 CDI79555.1 - 1.1e-10 42.1 0.0 1.7e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-RING_2 PF13639.6 CDI79556.1 - 3.5e-05 24.0 13.7 3.5e-05 24.0 13.7 2.9 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDI79556.1 - 0.00013 21.8 10.0 0.00013 21.8 10.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI79556.1 - 0.00028 20.7 14.2 0.00028 20.7 14.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI79556.1 - 0.0021 17.9 12.8 0.0021 17.9 12.8 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Sina PF03145.16 CDI79556.1 - 0.0025 17.8 2.3 0.0025 17.8 2.3 4.5 2 1 3 5 5 5 3 Seven in absentia protein family zf-C3HC4_4 PF15227.6 CDI79556.1 - 0.0055 16.8 12.5 0.024 14.8 12.5 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-TRAF PF02176.18 CDI79556.1 - 0.0067 17.1 12.4 0.03 15.0 6.3 3.9 2 1 3 5 5 5 2 TRAF-type zinc finger zf-RING_UBOX PF13445.6 CDI79556.1 - 0.012 15.6 13.5 0.012 15.6 13.5 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 CDI79556.1 - 0.012 15.7 5.2 0.012 15.7 5.2 2.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-TRAF_2 PF15965.5 CDI79556.1 - 0.48 10.9 22.3 0.088 13.3 3.5 3.2 1 1 2 3 3 3 0 TRAF-like zinc-finger Voltage_CLC PF00654.20 CDI79557.1 - 4.1e-31 108.5 34.9 3.5e-15 56.1 6.9 4.9 5 1 1 6 6 6 3 Voltage gated chloride channel zf-CCCH PF00642.24 CDI79558.1 - 1.5e-09 37.5 11.0 4.3e-07 29.7 1.2 3.4 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI79558.1 - 4.3e-07 29.8 16.5 0.00018 21.4 1.9 3.5 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 CDI79558.1 - 0.0034 17.1 1.6 0.0034 17.1 1.6 4.0 3 2 1 4 4 4 1 CCCH-type zinc finger Torus PF16131.5 CDI79558.1 - 0.057 14.1 0.2 0.057 14.1 0.2 3.2 3 0 0 3 3 3 0 Torus domain zf-CCCH_3 PF15663.5 CDI79558.1 - 0.57 10.4 7.5 8 6.7 3.1 2.6 1 1 1 2 2 2 0 Zinc-finger containing family Spt20 PF12090.8 CDI79558.1 - 0.99 9.0 8.8 1.5 8.4 8.8 1.2 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 CDI79558.1 - 1.4 9.1 13.7 4.4 7.4 13.7 2.1 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-CCCH_2 PF14608.6 CDI79558.1 - 3.1 8.4 17.2 3 8.4 0.9 3.8 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger HSD3 PF15244.6 CDI79559.1 - 5.7 6.3 10.7 8.4 5.8 10.7 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 Cir_N PF10197.9 CDI79560.1 - 3.5e-12 46.3 13.4 3.5e-12 46.3 13.4 3.8 2 1 1 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR BTK PF00779.19 CDI79560.1 - 0.38 10.6 3.5 5.7 6.8 0.9 2.6 2 0 0 2 2 2 0 BTK motif HSP70 PF00012.20 CDI79560.1 - 2.3 6.3 10.2 3.4 5.8 10.2 1.2 1 0 0 1 1 1 0 Hsp70 protein DEAD PF00270.29 CDI79561.1 - 4e-27 95.1 0.0 1.2e-26 93.6 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79561.1 - 7.9e-20 71.3 0.0 2e-19 70.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI79561.1 - 0.17 11.9 0.0 16 5.5 0.0 2.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SWIRM-assoc_2 PF16496.5 CDI79561.1 - 0.75 8.6 4.7 1.4 7.7 4.7 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal EF-hand_6 PF13405.6 CDI79562.1 - 7.2e-12 44.2 0.0 5.6e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CDI79562.1 - 9.4e-12 45.2 0.1 1.3e-05 25.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI79562.1 - 7.8e-11 40.7 0.0 0.00047 19.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 CDI79562.1 - 2.9e-06 27.5 0.0 0.058 13.7 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CDI79562.1 - 1.1e-05 25.1 0.0 0.065 13.1 0.0 3.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 CDI79562.1 - 0.00059 19.2 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 2 EF hand BRCT_2 PF16589.5 CDI79563.1 - 0.0003 21.1 0.0 0.00087 19.7 0.0 1.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain IBR PF01485.21 CDI79564.1 - 3.5e-18 65.6 29.5 2.4e-09 37.3 6.4 4.1 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain PPDK_N PF01326.19 CDI79565.1 - 1e-15 57.8 0.0 3.7e-14 52.7 0.0 3.2 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain DUF4355 PF14265.6 CDI79565.1 - 0.017 15.3 0.4 0.064 13.5 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) RPN13_C PF16550.5 CDI79565.1 - 0.073 13.3 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 UCH-binding domain Pro_isomerase PF00160.21 CDI79569.1 - 1.3e-27 97.1 0.0 7e-27 94.6 0.0 2.2 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CDI79569.1 - 8e-16 57.6 0.0 1.5e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CDI79569.1 - 0.013 15.6 0.5 0.013 15.6 0.5 2.1 2 0 0 2 2 2 0 RNA binding motif SUIM_assoc PF16619.5 CDI79569.1 - 0.99 9.5 26.0 0.1 12.7 5.0 3.3 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 IMP2_N PF18590.1 CDI79570.1 - 6.4e-27 93.9 0.9 1e-26 93.3 0.9 1.3 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain ATG22 PF11700.8 CDI79572.1 - 0.017 13.8 1.3 0.042 12.5 1.3 1.6 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Nmad2 PF18753.1 CDI79572.1 - 2.6 7.4 7.3 0.36 10.3 1.9 2.2 2 0 0 2 2 2 0 Nucleotide modification associated domain 2 EF-hand_6 PF13405.6 CDI79573.1 - 1.6e-06 27.6 0.1 4.2e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 CDI79573.1 - 6.8e-06 25.3 0.4 1.3e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDI79573.1 - 1.9e-05 25.0 0.1 4.3e-05 23.9 0.1 1.6 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 CDI79573.1 - 0.038 13.5 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_9 PF14658.6 CDI79573.1 - 0.045 14.1 0.0 0.096 13.0 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Adenine_glyco PF03352.13 CDI79573.1 - 0.22 11.3 0.0 0.35 10.6 0.0 1.4 1 1 0 1 1 1 0 Methyladenine glycosylase ABC_tran PF00005.27 CDI79574.1 - 9.4e-48 162.2 0.0 1.4e-25 90.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CDI79574.1 - 7.1e-22 78.0 29.3 6.4e-15 55.1 0.0 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CDI79574.1 - 2.1e-15 57.4 3.1 1.7e-07 31.4 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDI79574.1 - 8.9e-05 22.2 2.0 0.061 13.1 0.1 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain SMC_N PF02463.19 CDI79574.1 - 0.001 18.6 0.2 5.6 6.3 0.0 3.7 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDI79574.1 - 0.0031 17.4 0.7 0.018 14.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 CDI79574.1 - 0.0061 17.1 4.5 0.027 15.0 0.1 2.7 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 CDI79574.1 - 0.057 12.7 0.5 0.28 10.5 0.0 2.3 3 0 0 3 3 3 0 Zeta toxin AAA_30 PF13604.6 CDI79574.1 - 0.067 12.9 0.1 8.8 6.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CDI79574.1 - 0.094 13.0 0.0 6.9 7.0 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 CDI79574.1 - 0.22 11.6 3.0 0.45 10.6 0.3 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase MeaB PF03308.16 CDI79574.1 - 0.26 10.2 0.6 1.8 7.5 0.2 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 CDI79574.1 - 0.99 9.5 4.6 0.31 11.1 0.4 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain Wzy_C PF04932.15 CDI79575.1 - 0.26 10.9 5.6 0.084 12.5 2.6 1.7 1 1 1 2 2 2 0 O-Antigen ligase TMEM192 PF14802.6 CDI79576.1 - 2.5 7.1 4.5 5.7 6.0 4.5 1.7 1 1 0 1 1 1 0 TMEM192 family TFIIIC_sub6 PF10419.9 CDI79577.1 - 0.051 13.4 1.7 0.083 12.8 1.7 1.5 1 1 0 1 1 1 0 TFIIIC subunit triple barrel domain Exo_endo_phos PF03372.23 CDI79577.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Spt20 PF12090.8 CDI79579.1 - 0.061 12.9 0.1 0.061 12.9 0.1 5.5 4 1 0 4 4 4 0 Spt20 family YtxH PF12732.7 CDI79580.1 - 7.7e-05 23.2 19.8 1.5e+02 3.0 19.8 2.8 1 1 0 1 1 1 0 YtxH-like protein DUF883 PF05957.13 CDI79580.1 - 0.0053 17.3 20.0 0.31 11.7 3.2 2.9 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) LEA_4 PF02987.16 CDI79580.1 - 0.0088 16.1 29.9 0.032 14.3 4.5 4.1 2 1 2 4 4 4 2 Late embryogenesis abundant protein ApoO PF09769.9 CDI79580.1 - 0.026 14.5 1.7 1.3 8.9 0.3 2.3 1 1 1 2 2 2 0 Apolipoprotein O Apolipoprotein PF01442.18 CDI79580.1 - 0.14 12.0 12.4 0.38 10.6 12.4 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain AD PF09793.9 CDI79580.1 - 0.21 11.8 0.1 0.21 11.8 0.1 2.5 2 1 1 3 3 3 0 Anticodon-binding domain ApoLp-III PF07464.11 CDI79580.1 - 0.86 9.7 7.9 3 7.9 7.9 1.8 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Stomoxyn PF11585.8 CDI79580.1 - 4.2 7.4 9.0 2.7 8.1 0.2 3.0 2 1 1 3 3 3 0 Insect antimicrobial peptide, stomoxyn DNA_ligase_A_M PF01068.21 CDI79582.1 - 9.1e-22 77.7 0.0 2.9e-21 76.1 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 CDI79582.1 - 1e-06 29.2 0.0 3.8e-06 27.3 0.0 2.0 1 0 0 1 1 1 1 RNA ligase DNA_ligase_IV PF11411.8 CDI79582.1 - 1.6e-05 24.9 0.2 3.2e-05 23.9 0.2 1.5 1 0 0 1 1 1 1 DNA ligase IV SUIM_assoc PF16619.5 CDI79582.1 - 0.0029 17.6 1.6 0.0029 17.6 1.6 8.8 7 3 2 9 9 9 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI79582.1 - 0.017 14.8 89.7 0.13 11.8 8.8 5.0 4 0 0 4 4 4 0 Spt20 family BRCT PF00533.26 CDI79582.1 - 0.099 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDI79582.1 - 0.13 12.7 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Metallothio_11 PF02066.15 CDI79582.1 - 0.86 9.8 7.5 3.4 7.9 7.5 2.1 1 0 0 1 1 1 0 Metallothionein family 11 BSP_II PF05432.11 CDI79583.1 - 0.62 9.7 15.0 0.014 15.1 2.7 2.9 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) PCI PF01399.27 CDI79587.1 - 1.5e-11 44.7 0.1 8.4e-11 42.3 0.0 1.8 1 1 0 1 1 1 1 PCI domain PreAtp-grasp PF18604.1 CDI79587.1 - 0.055 13.1 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Pre ATP-grasp domain HTH_Mga PF08280.11 CDI79587.1 - 0.18 11.8 1.0 0.41 10.7 1.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain DUF5327 PF17261.2 CDI79588.1 - 0.0054 17.4 10.6 0.0076 17.0 10.6 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5327) Peptidase_S49_N PF08496.10 CDI79588.1 - 0.0081 16.2 5.7 0.01 15.9 5.7 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal FHIPEP PF00771.20 CDI79588.1 - 0.026 13.0 4.5 0.029 12.9 4.5 1.0 1 0 0 1 1 1 0 FHIPEP family ADP_ribosyl_GH PF03747.14 CDI79588.1 - 0.034 13.9 10.3 0.043 13.5 10.3 1.0 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase DUF719 PF05334.13 CDI79588.1 - 0.052 13.7 6.7 0.06 13.5 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) TFIIA PF03153.13 CDI79588.1 - 0.053 13.5 30.6 0.055 13.5 30.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI79588.1 - 0.072 12.7 28.9 0.086 12.4 28.9 1.1 1 0 0 1 1 1 0 Spt20 family Connexin PF00029.19 CDI79588.1 - 0.073 12.8 1.9 0.075 12.8 1.9 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 CDI79588.1 - 0.1 11.3 9.9 0.11 11.3 9.9 1.2 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 CDI79588.1 - 0.11 12.2 2.3 0.12 12.1 2.3 1.2 1 0 0 1 1 1 0 FAM176 family SID-1_RNA_chan PF13965.6 CDI79588.1 - 0.13 10.6 0.6 0.13 10.6 0.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3487 PF11990.8 CDI79588.1 - 0.15 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) SLC12 PF03522.15 CDI79588.1 - 0.19 10.7 6.3 0.17 10.9 6.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Activator_LAG-3 PF11498.8 CDI79588.1 - 0.19 10.6 31.3 0.25 10.3 31.3 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF1980 PF09323.10 CDI79588.1 - 0.21 11.5 2.0 0.25 11.3 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Peptidase_S15 PF02129.18 CDI79588.1 - 0.25 10.9 9.4 0.27 10.8 9.4 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) eIF-3_zeta PF05091.12 CDI79588.1 - 0.26 10.2 12.0 0.28 10.1 12.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EIIBC-GUT_N PF03612.14 CDI79588.1 - 0.33 10.7 4.4 0.35 10.6 4.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Ctr PF04145.15 CDI79588.1 - 0.35 11.5 3.2 0.4 11.3 3.2 1.2 1 0 0 1 1 1 0 Ctr copper transporter family CBP_BcsG PF11658.8 CDI79588.1 - 0.35 9.2 7.7 0.4 9.0 7.7 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG YppG PF14179.6 CDI79588.1 - 0.36 11.5 22.9 0.49 11.1 22.9 1.1 1 0 0 1 1 1 0 YppG-like protein UPF0560 PF10577.9 CDI79588.1 - 0.39 9.2 17.8 0.44 9.0 17.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Neur_chan_memb PF02932.16 CDI79588.1 - 0.47 10.5 6.2 0.45 10.5 6.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 CDI79588.1 - 0.54 10.4 7.6 0.58 10.3 7.6 1.1 1 0 0 1 1 1 0 DDHD domain Serinc PF03348.15 CDI79588.1 - 0.56 9.1 2.9 0.63 8.9 2.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) OATP PF03137.20 CDI79588.1 - 0.67 8.2 2.2 0.72 8.1 2.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Lin-8 PF03353.15 CDI79588.1 - 0.68 9.4 15.5 0.77 9.3 15.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TERB2 PF15101.6 CDI79588.1 - 0.88 9.6 15.0 1.1 9.3 15.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CPSF100_C PF13299.6 CDI79588.1 - 1.1 9.5 9.1 1.2 9.3 9.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Baculo_PP31 PF05311.11 CDI79588.1 - 1.4 8.3 8.4 1.6 8.2 8.4 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) RR_TM4-6 PF06459.12 CDI79588.1 - 1.8 8.3 10.7 1.9 8.3 10.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paramyxo_ncap PF00973.19 CDI79588.1 - 2 7.2 10.3 2.4 7.0 10.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PAT1 PF09770.9 CDI79588.1 - 2.4 6.3 20.2 2.4 6.3 20.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4834 PF16118.5 CDI79588.1 - 2.5 9.1 13.4 4 8.5 13.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Coilin_N PF15862.5 CDI79588.1 - 4.3 7.1 12.1 5.9 6.7 12.1 1.3 1 0 0 1 1 1 0 Coilin N-terminus ALMT PF11744.8 CDI79588.1 - 5.3 5.8 8.3 5.4 5.7 8.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2722 PF10846.8 CDI79588.1 - 6.3 5.6 26.5 8.2 5.3 26.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Peptidase_S64 PF08192.11 CDI79588.1 - 6.8 5.1 10.7 7.2 5.0 10.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 CDI79588.1 - 7.3 3.6 13.0 7.3 3.6 13.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MCU PF04678.13 CDI79588.1 - 8.2 6.5 9.8 10 6.2 9.8 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Roughex PF06020.11 CDI79588.1 - 8.5 5.4 12.0 10 5.1 12.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DivIC PF04977.15 CDI79588.1 - 8.7 6.2 15.4 14 5.5 15.4 1.4 1 0 0 1 1 1 0 Septum formation initiator V_ATPase_I PF01496.19 CDI79588.1 - 9.2 4.0 9.9 10 3.9 9.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BRF1 PF07741.13 CDI79588.1 - 9.3 6.7 12.6 13 6.2 12.6 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain SWIM PF04434.17 CDI79592.1 - 0.0029 17.2 0.4 0.0029 17.2 0.4 2.5 2 0 0 2 2 2 1 SWIM zinc finger AAA_23 PF13476.6 CDI79592.1 - 0.098 13.1 10.1 0.16 12.4 10.1 1.3 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.9 CDI79592.1 - 1.1 7.4 19.4 1.7 6.9 19.4 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOBP PF15279.6 CDI79592.1 - 2.6 8.6 20.6 4.2 7.9 20.6 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein SUIM_assoc PF16619.5 CDI79593.1 - 1 9.5 8.1 1 9.5 8.1 1.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI79596.1 - 3.1e-07 30.9 0.0 3.1e-07 30.9 0.0 7.9 4 3 2 7 7 7 3 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI79596.1 - 0.00027 20.7 75.2 0.052 13.1 10.8 5.4 5 0 0 5 5 5 4 Spt20 family RAP1 PF07218.11 CDI79596.1 - 0.01 14.2 0.2 0.01 14.2 0.2 3.2 3 0 0 3 3 3 0 Rhoptry-associated protein 1 (RAP-1) Sin_N PF04801.13 CDI79596.1 - 0.077 12.2 0.0 0.077 12.2 0.0 4.4 4 1 0 4 4 4 0 Sin-like protein conserved region SIR2_2 PF13289.6 CDI79596.1 - 0.27 11.3 3.4 0.69 10.0 0.0 3.0 3 0 0 3 3 3 0 SIR2-like domain Ferlin_C PF16165.5 CDI79596.1 - 3.8 7.4 4.9 8.7 6.3 1.3 2.9 3 0 0 3 3 3 0 Ferlin C-terminus N6_N4_Mtase PF01555.18 CDI79596.1 - 4.1 7.0 5.6 6.7 6.3 1.6 2.5 3 0 0 3 3 3 0 DNA methylase WBP-1 PF11669.8 CDI79596.1 - 5.5 7.7 21.2 2.7 8.7 0.4 5.3 5 0 0 5 5 5 0 WW domain-binding protein 1 O-antigen_lig PF13425.6 CDI79596.1 - 7.6 5.2 6.4 5.8 5.6 0.0 2.2 2 0 0 2 2 2 0 O-antigen ligase like membrane protein SUIM_assoc PF16619.5 CDI79597.1 - 0.0069 16.4 2.1 0.0069 16.4 2.1 14.0 10 3 2 12 12 12 4 Unstructured region C-term to UIM in Ataxin3 AdoMet_MTase PF07757.13 CDI79597.1 - 0.25 11.7 0.5 0.73 10.2 0.0 1.9 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase NOA36 PF06524.12 CDI79599.1 - 5.1 6.3 11.0 5.6 6.2 5.1 2.1 2 0 0 2 2 2 0 NOA36 protein FAM176 PF14851.6 CDI79599.1 - 8.1 6.1 16.3 6.9 6.3 5.8 2.3 2 0 0 2 2 2 0 FAM176 family Glycos_transf_2 PF00535.26 CDI79600.1 - 4.4e-26 91.7 0.0 7.4e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDI79600.1 - 4.6e-06 26.9 0.0 0.00038 20.7 0.0 2.5 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 CDI79600.1 - 2.8e-05 24.1 1.0 4.1e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDI79600.1 - 0.0001 21.9 1.0 0.00025 20.6 0.6 1.8 1 1 1 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDI79600.1 - 0.0026 17.3 0.0 0.011 15.3 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 TFIIF_alpha PF05793.12 CDI79600.1 - 5.2 5.6 22.7 8.4 4.9 22.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM196 PF15265.6 CDI79600.1 - 9.7 5.6 12.4 14 5.0 12.4 1.1 1 0 0 1 1 1 0 FAM196 family SUIM_assoc PF16619.5 CDI79601.1 - 0.017 15.2 2.9 0.017 15.2 2.9 7.9 5 2 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 CDI79602.1 - 8.7e-51 172.8 0.0 2e-50 171.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79602.1 - 1.8e-23 83.2 0.0 4.4e-23 81.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 CDI79602.1 - 0.0031 17.1 0.0 0.016 14.8 0.0 2.1 1 1 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 CDI79602.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3486 PF11985.8 CDI79603.1 - 0.048 14.1 5.9 1.1 9.6 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3486) DUF5106 PF17127.4 CDI79603.1 - 0.078 13.3 0.8 0.17 12.1 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5106) ubiquitin PF00240.23 CDI79604.1 - 1.5e-23 82.4 0.2 1.6e-23 82.2 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDI79604.1 - 2.2e-11 43.4 0.2 2.4e-11 43.3 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDI79604.1 - 0.00018 21.9 0.0 0.00018 21.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDI79604.1 - 0.001 19.0 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain MS_channel PF00924.18 CDI79605.1 - 2e-15 56.9 1.2 2e-15 56.9 1.2 3.1 2 1 0 2 2 2 1 Mechanosensitive ion channel Lin-8 PF03353.15 CDI79605.1 - 7 6.1 37.2 0.83 9.2 18.2 3.2 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist TIM PF00121.18 CDI79606.1 - 2.2e-85 285.9 2.9 9.5e-82 274.0 1.4 2.0 2 0 0 2 2 2 2 Triosephosphate isomerase RAP PF08373.10 CDI79608.1 - 0.0043 17.1 0.1 0.0043 17.1 0.1 3.2 4 0 0 4 4 4 2 RAP domain SUIM_assoc PF16619.5 CDI79609.1 - 0.0011 19.0 1.1 0.0012 18.9 1.1 1.3 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI79609.1 - 0.3 10.7 4.5 0.35 10.4 4.5 1.1 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI79609.1 - 0.32 10.2 8.4 0.36 10.0 8.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal COX14 PF14880.6 CDI79609.1 - 1.5 8.7 5.2 8.4 6.3 0.8 2.3 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Pyr_redox_2 PF07992.14 CDI79610.1 - 6e-18 65.1 7.0 1.5e-17 63.8 0.0 2.7 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDI79610.1 - 1.1e-09 38.7 0.1 2e-07 31.5 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDI79610.1 - 0.11 11.7 0.1 0.37 10.0 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 CDI79610.1 - 0.15 11.8 4.5 15 5.3 0.0 3.7 4 0 0 4 4 4 0 Thiamine pyrophosphate enzyme, central domain K_oxygenase PF13434.6 CDI79610.1 - 0.17 11.0 0.2 11 5.1 0.1 2.3 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CDI79610.1 - 0.3 11.3 7.2 0.81 10.0 0.0 4.1 4 0 0 4 4 4 0 NAD(P)-binding Rossmann-like domain SUIM_assoc PF16619.5 CDI79610.1 - 0.85 9.7 8.6 0.24 11.5 4.7 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4551 PF15087.6 CDI79611.1 - 0.0051 15.7 29.2 0.0059 15.5 29.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) Hid1 PF12722.7 CDI79611.1 - 0.035 12.3 32.3 0.046 11.8 32.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FliP PF00813.20 CDI79611.1 - 0.14 12.0 5.1 0.28 11.0 5.1 1.6 1 1 0 1 1 1 0 FliP family LAP1C PF05609.12 CDI79611.1 - 0.26 10.3 32.9 0.32 10.0 32.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) AF-4 PF05110.13 CDI79611.1 - 0.28 9.2 41.2 0.36 8.9 41.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Cas1_AcylT PF07779.12 CDI79611.1 - 1.9 7.3 4.0 1.3 7.9 0.3 2.2 1 1 1 2 2 2 0 10 TM Acyl Transferase domain found in Cas1p RAP1 PF07218.11 CDI79611.1 - 2.8 6.1 8.3 3.4 5.8 8.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDK5_activator PF03261.15 CDI79611.1 - 3.3 7.2 24.5 3.9 6.9 24.5 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF966 PF06136.13 CDI79611.1 - 3.9 7.1 30.6 4.8 6.8 30.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) SOBP PF15279.6 CDI79611.1 - 5.1 7.6 33.1 6.3 7.3 33.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein GREB1 PF15782.5 CDI79611.1 - 6.9 3.6 33.1 7.8 3.5 33.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI79611.1 - 8.2 4.6 44.9 12 4.1 44.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LptF_LptG PF03739.14 CDI79611.1 - 9.3 5.0 9.4 12 4.6 9.4 1.3 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG UCH PF00443.29 CDI79612.1 - 1.7e-37 129.3 0.0 5.5e-37 127.6 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDI79612.1 - 1.5e-14 54.3 0.0 6.2e-06 26.0 0.0 3.7 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase FliM PF02154.15 CDI79612.1 - 0.048 13.5 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM DUF3185 PF11381.8 CDI79613.1 - 0.027 14.5 2.4 0.065 13.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) Conotoxin PF02950.17 CDI79613.1 - 0.2 12.7 2.4 1 10.4 0.0 2.8 3 0 0 3 3 3 0 Conotoxin TctB PF07331.11 CDI79613.1 - 0.42 10.9 4.0 1.8 8.8 1.9 2.4 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family GDP_Man_Dehyd PF16363.5 CDI79614.1 - 1.9e-128 428.5 0.0 2.2e-128 428.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDI79614.1 - 1.5e-64 217.7 0.0 1.9e-64 217.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDI79614.1 - 1.8e-08 33.8 0.0 2.5e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDI79614.1 - 2.1e-05 23.8 0.0 3.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CDI79614.1 - 0.0042 16.7 0.1 0.0077 15.8 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family SUIM_assoc PF16619.5 CDI79616.1 - 0.0047 17.0 2.8 0.0047 17.0 2.8 4.8 4 1 1 5 5 5 3 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI79616.1 - 0.14 12.5 39.1 0.45 10.8 6.4 3.1 1 1 2 3 3 3 0 Anti-sigma-K factor rskA His_Phos_2 PF00328.22 CDI79617.1 - 1.3e-07 31.3 26.1 4e-05 23.1 0.0 4.2 4 0 0 4 4 4 3 Histidine phosphatase superfamily (branch 2) ELMO_CED12 PF04727.13 CDI79618.1 - 1e-13 51.8 0.1 2e-11 44.3 0.0 2.3 2 1 0 2 2 2 2 ELMO/CED-12 family GPHH PF16905.5 CDI79618.1 - 0.41 10.5 1.4 0.47 10.3 0.0 1.7 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Caldesmon PF02029.15 CDI79621.1 - 4.4 6.0 44.5 6.4 5.4 44.5 1.2 1 0 0 1 1 1 0 Caldesmon Sin_N PF04801.13 CDI79622.1 - 0.0015 17.9 2.4 0.0015 17.9 2.4 5.8 5 1 1 6 6 6 1 Sin-like protein conserved region Spt20 PF12090.8 CDI79622.1 - 0.0016 18.1 7.8 0.0016 18.1 7.8 8.2 7 2 0 7 7 7 3 Spt20 family SUIM_assoc PF16619.5 CDI79622.1 - 0.0056 16.7 2.1 0.0056 16.7 2.1 13.3 9 3 0 9 9 9 3 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI79622.1 - 0.051 13.9 0.0 0.051 13.9 0.0 10.9 4 3 5 10 10 10 0 Anti-sigma-K factor rskA PGP_phosphatase PF09419.10 CDI79622.1 - 0.1 12.2 0.1 0.43 10.2 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase SID-1_RNA_chan PF13965.6 CDI79622.1 - 0.62 8.4 7.9 1.6 7.1 0.4 3.2 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 Aminotran_5 PF00266.19 CDI79623.1 - 4.2e-38 131.3 0.0 5.8e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Pyridoxal_deC PF00282.19 CDI79623.1 - 0.0099 14.6 0.1 1.8 7.2 0.0 2.2 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain CoA_binding_2 PF13380.6 CDI79623.1 - 0.023 15.2 0.1 0.27 11.7 0.0 2.5 3 0 0 3 3 3 0 CoA binding domain DUF2722 PF10846.8 CDI79623.1 - 0.15 11.0 5.2 0.18 10.7 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI79623.1 - 0.16 11.5 8.3 0.23 11.1 8.3 1.2 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI79624.1 - 0.00012 22.4 3.6 0.00012 22.4 3.6 9.0 5 2 1 6 6 6 2 Anti-sigma-K factor rskA adh_short_C2 PF13561.6 CDI79625.1 - 6.9e-41 140.3 16.2 1e-32 113.6 0.0 3.7 4 0 0 4 4 4 3 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDI79625.1 - 1.1e-10 41.2 0.2 7.3e-09 35.4 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Enoyl_reductase PF12241.8 CDI79625.1 - 0.00028 20.3 0.2 0.17 11.2 0.0 2.3 1 1 1 2 2 2 2 Trans-2-enoyl-CoA reductase catalytic region SOG2 PF10428.9 CDI79625.1 - 0.1 11.8 12.2 1.2 8.3 7.9 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein TFIIA PF03153.13 CDI79625.1 - 9.4 6.1 13.0 0.53 10.2 2.2 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Es2 PF09751.9 CDI79626.1 - 2.2e-15 57.4 31.5 2.1e-09 37.7 4.6 7.0 4 2 2 6 6 6 4 Nuclear protein Es2 ORC5_C PF14630.6 CDI79627.1 - 9.8e-13 48.2 0.2 9.8e-13 48.2 0.2 4.1 4 1 0 4 4 4 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 CDI79627.1 - 1.6e-06 28.6 6.2 1.6e-06 28.6 6.2 4.5 3 2 1 4 4 4 1 AAA ATPase domain DUF2791 PF10923.8 CDI79627.1 - 0.00025 20.0 0.5 0.00025 20.0 0.5 1.6 2 0 0 2 2 2 1 P-loop Domain of unknown function (DUF2791) ABC_tran PF00005.27 CDI79627.1 - 0.00042 20.8 3.2 0.0011 19.5 0.1 2.4 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 CDI79627.1 - 0.042 14.1 2.6 0.054 13.8 0.4 2.3 2 1 0 2 2 2 0 AAA domain Spt20 PF12090.8 CDI79627.1 - 0.052 13.2 56.9 0.1 12.2 20.1 3.3 3 0 0 3 3 3 0 Spt20 family Otopetrin PF03189.13 CDI79627.1 - 0.091 11.6 0.0 0.8 8.5 0.0 2.2 1 1 0 1 1 1 0 Otopetrin EOS1 PF12326.8 CDI79627.1 - 1.9 8.4 5.3 23 4.8 1.9 2.6 2 1 0 2 2 2 0 N-glycosylation protein DEAD PF00270.29 CDI79628.1 - 6.8e-35 120.4 0.0 6.8e-35 120.4 0.0 2.3 3 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79628.1 - 2.9e-24 85.6 0.2 2e-23 82.8 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI79628.1 - 4.6e-06 26.7 4.8 5e-06 26.6 0.0 3.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CDI79628.1 - 0.013 15.9 0.0 0.013 15.9 0.0 4.1 5 0 0 5 5 5 0 AAA domain RskA PF10099.9 CDI79628.1 - 0.039 14.2 0.0 0.039 14.2 0.0 4.3 3 1 1 4 4 4 0 Anti-sigma-K factor rskA MecA PF05389.12 CDI79628.1 - 0.16 11.6 0.0 0.16 11.6 0.0 3.0 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) AAA_22 PF13401.6 CDI79628.1 - 0.25 11.6 0.1 0.25 11.6 0.1 5.5 3 1 2 5 5 5 0 AAA domain SWI2_SNF2 PF18766.1 CDI79628.1 - 0.48 10.1 0.0 0.48 10.1 0.0 3.9 4 0 0 4 4 4 0 SWI2/SNF2 ATPase Otopetrin PF03189.13 CDI79628.1 - 8.5 5.1 5.6 4.1 6.1 0.0 2.3 2 0 0 2 2 2 0 Otopetrin AP2 PF00847.20 CDI79629.1 - 1.2e-06 28.7 0.4 1.2e-06 28.7 0.4 3.0 4 0 0 4 4 4 1 AP2 domain TFIIA PF03153.13 CDI79629.1 - 0.48 10.4 14.5 0.77 9.7 14.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit His_Phos_1 PF00300.22 CDI79631.1 - 1.7e-38 132.3 0.0 2.7e-30 105.5 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) TAF6_C PF07571.13 CDI79631.1 - 0.097 13.0 0.0 0.33 11.3 0.0 1.9 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain DUF3549 PF12069.8 CDI79633.1 - 3.9 6.4 8.0 2.8 6.9 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3549) Ribosomal_S7 PF00177.21 CDI79635.1 - 2.3e-21 76.0 0.1 4.7e-21 75.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e CS PF04969.16 CDI79636.1 - 2.6e-07 31.6 0.0 5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 CS domain IMCp PF12314.8 CDI79637.1 - 1.9e-10 40.9 59.0 2.2e-08 34.3 36.9 3.2 1 1 2 3 3 3 3 Inner membrane complex protein SR-25 PF10500.9 CDI79638.1 - 1.9 8.0 27.0 0.47 10.0 5.7 2.2 1 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Muted PF14942.6 CDI79638.1 - 7.7 6.9 32.8 10 6.4 16.0 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein BRF1 PF07741.13 CDI79639.1 - 0.017 15.4 2.8 0.021 15.1 2.8 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain SUIM_assoc PF16619.5 CDI79639.1 - 0.024 14.7 11.1 0.032 14.3 11.1 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Macoilin PF09726.9 CDI79640.1 - 0.018 13.6 32.5 0.021 13.4 32.5 1.0 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI79640.1 - 0.028 14.4 21.7 0.032 14.2 21.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4647 PF15504.6 CDI79640.1 - 0.086 11.9 14.3 0.09 11.9 14.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Presenilin PF01080.17 CDI79640.1 - 0.33 9.7 20.8 0.38 9.5 20.8 1.1 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 CDI79640.1 - 0.53 10.5 20.0 0.61 10.3 20.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NST1 PF13945.6 CDI79640.1 - 0.65 10.1 29.7 0.94 9.6 29.7 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Pol_alpha_B_N PF08418.10 CDI79640.1 - 0.69 9.8 17.2 0.88 9.5 17.2 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal SPX PF03105.19 CDI79640.1 - 0.76 9.6 31.5 0.94 9.3 31.5 1.1 1 0 0 1 1 1 0 SPX domain Miga PF10265.9 CDI79640.1 - 0.83 8.6 25.0 1 8.3 25.0 1.0 1 0 0 1 1 1 0 Mitoguardin SLC12 PF03522.15 CDI79640.1 - 1.1 8.3 16.2 1.2 8.1 16.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 CDI79640.1 - 1.4 7.7 31.6 1.7 7.4 31.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PA26 PF04636.13 CDI79640.1 - 1.7 7.5 9.3 1.7 7.4 9.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sporozoite_P67 PF05642.11 CDI79640.1 - 2.1 6.3 22.8 2.4 6.1 22.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen XRN_M PF17846.1 CDI79640.1 - 2.3 7.1 7.6 2.5 6.9 7.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain PAT1 PF09770.9 CDI79640.1 - 3.1 6.0 14.0 3.4 5.8 14.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RHINO PF15319.6 CDI79640.1 - 4.2 7.3 19.2 6.2 6.8 19.2 1.3 1 0 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein Herpes_capsid PF06112.11 CDI79640.1 - 8.6 6.4 34.2 11 6.0 34.2 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein DUF4551 PF15087.6 CDI79640.1 - 8.6 5.1 24.0 9.4 4.9 24.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Plasmodium_Vir PF05795.11 CDI79640.1 - 8.7 5.6 17.6 10 5.4 17.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Membralin PF09746.9 CDI79640.1 - 9.1 5.2 6.6 11 5.0 6.6 1.2 1 0 0 1 1 1 0 Tumour-associated protein TFIIA PF03153.13 CDI79641.1 - 0.11 12.4 36.3 0.14 12.2 36.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI79641.1 - 3.7 5.7 21.8 3.6 5.7 21.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NARP1 PF12569.8 CDI79641.1 - 5.1 5.9 7.8 6.6 5.5 7.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SUIM_assoc PF16619.5 CDI79642.1 - 0.00089 19.3 0.0 0.00089 19.3 0.0 11.3 7 2 0 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 DUF4179 PF13786.6 CDI79642.1 - 0.27 11.7 0.1 0.27 11.7 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4179) O-antigen_lig PF13425.6 CDI79642.1 - 0.94 8.2 7.8 1.7 7.4 7.8 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SID-1_RNA_chan PF13965.6 CDI79642.1 - 6.1 5.1 8.6 11 4.3 8.6 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ORC3_N PF07034.11 CDI79643.1 - 1e-08 34.7 8.3 1e-08 34.7 8.3 5.2 4 1 0 4 4 4 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 CDI79643.1 - 0.00048 20.2 3.3 0.00048 20.2 3.3 6.4 5 1 1 6 6 6 1 Origin recognition complex winged helix C-terminal EGF_CA PF07645.15 CDI79644.1 - 8.1e-28 96.4 72.9 1.3e-10 41.3 8.0 5.7 5 0 0 5 5 5 5 Calcium-binding EGF domain cEGF PF12662.7 CDI79644.1 - 1.3e-13 50.5 36.3 0.00014 21.7 0.8 6.5 5 1 0 5 5 5 4 Complement Clr-like EGF-like EGF_3 PF12947.7 CDI79644.1 - 1.6e-12 47.4 73.1 3.9e-06 27.0 9.9 6.0 6 0 0 6 6 6 5 EGF domain EGF PF00008.27 CDI79644.1 - 1.4e-05 25.3 62.0 0.012 15.9 7.2 6.7 6 1 0 6 6 6 5 EGF-like domain EGF_MSP1_1 PF12946.7 CDI79644.1 - 0.0022 18.0 7.3 0.0022 18.0 7.3 5.2 4 1 2 6 6 6 2 MSP1 EGF domain 1 hEGF PF12661.7 CDI79644.1 - 0.0085 16.7 4.5 0.0085 16.7 4.5 7.4 7 0 0 7 7 7 2 Human growth factor-like EGF FXa_inhibition PF14670.6 CDI79644.1 - 0.01 16.1 66.1 0.072 13.4 8.3 5.8 5 0 0 5 5 5 0 Coagulation Factor Xa inhibitory site 14-3-3 PF00244.20 CDI79645.1 - 1.1e-98 329.1 7.4 1.3e-98 328.9 7.4 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 CDI79645.1 - 0.029 13.9 0.0 0.055 12.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase MKT1_N PF12247.8 CDI79645.1 - 0.11 12.8 1.3 0.27 11.6 0.1 2.3 2 1 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication FAM176 PF14851.6 CDI79646.1 - 0.17 11.5 0.0 0.43 10.2 0.0 1.6 1 0 0 1 1 1 0 FAM176 family DUF3693 PF12472.8 CDI79647.1 - 0.0089 15.7 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 Phage related protein Prefoldin PF02996.17 CDI79649.1 - 6.7e-21 74.4 4.8 9.9e-21 73.9 4.8 1.3 1 0 0 1 1 1 1 Prefoldin subunit eIF-4B PF06273.11 CDI79649.1 - 0.0044 16.1 0.8 0.0059 15.7 0.8 1.2 1 0 0 1 1 1 1 Plant specific eukaryotic initiation factor 4B CHDCT2 PF08074.11 CDI79649.1 - 0.17 12.0 2.5 1.8 8.7 0.1 2.2 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Nsp1_C PF05064.13 CDI79649.1 - 0.51 10.2 7.2 0.061 13.1 1.3 2.2 2 0 0 2 2 2 0 Nsp1-like C-terminal region TMPIT PF07851.13 CDI79649.1 - 0.52 9.5 7.0 0.58 9.3 0.1 2.0 2 0 0 2 2 2 0 TMPIT-like protein DUF1127 PF06568.11 CDI79649.1 - 4.5 7.1 6.7 11 5.8 0.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1127) TFIID_30kDa PF03540.13 CDI79650.1 - 0.00011 22.1 0.1 0.00034 20.5 0.1 1.9 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit NUP50 PF08911.11 CDI79651.1 - 0.0012 19.5 1.8 0.0049 17.5 1.8 2.2 1 0 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) zf-A20 PF01754.16 CDI79652.1 - 7.8e-11 41.7 7.3 7.8e-11 41.7 7.3 1.8 2 0 0 2 2 2 1 A20-like zinc finger Mpv17_PMP22 PF04117.12 CDI79653.1 - 0.0066 16.7 0.4 0.015 15.5 0.0 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family Connexin PF00029.19 CDI79653.1 - 0.012 15.4 4.5 0.2 11.4 0.2 2.2 2 0 0 2 2 2 0 Connexin DUF2500 PF10694.9 CDI79653.1 - 0.058 13.9 2.7 12 6.4 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) Bac_export_2 PF01312.19 CDI79653.1 - 0.091 12.0 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Cadherin_C_2 PF16492.5 CDI79653.1 - 0.2 12.4 4.2 1 10.1 0.2 2.7 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal SID-1_RNA_chan PF13965.6 CDI79653.1 - 0.43 8.9 2.7 1.3 7.3 0.6 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Spt20 PF12090.8 CDI79653.1 - 1.4 8.5 38.1 1.5 8.4 7.5 3.1 3 0 0 3 3 3 0 Spt20 family Suf PF05843.14 CDI79653.1 - 2.5 8.0 15.8 5.8 6.8 6.7 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Roughex PF06020.11 CDI79653.1 - 3 6.9 14.0 3.4 6.7 1.5 2.5 2 0 0 2 2 2 0 Drosophila roughex protein CLN3 PF02487.17 CDI79653.1 - 9.7 5.1 7.7 8 5.4 0.6 2.2 2 0 0 2 2 2 0 CLN3 protein LCCL PF03815.19 CDI79654.1 - 2e-19 69.5 0.2 2e-19 69.5 0.2 2.9 2 1 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.25 CDI79654.1 - 8.7e-15 55.0 5.7 1e-12 48.2 0.0 3.3 3 0 0 3 3 3 2 F5/8 type C domain COLFI PF01410.18 CDI79654.1 - 8.6e-05 21.9 0.0 0.00017 21.0 0.0 1.4 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_N PF00055.17 CDI79654.1 - 0.0048 16.5 0.0 0.021 14.4 0.0 2.1 1 1 1 2 2 2 1 Laminin N-terminal (Domain VI) Rxt3 PF08642.10 CDI79654.1 - 0.033 15.0 0.4 0.033 15.0 0.4 2.7 2 1 0 2 2 2 0 Histone deacetylation protein Rxt3 Fibrinogen_C PF00147.18 CDI79654.1 - 0.1 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain Macoilin PF09726.9 CDI79654.1 - 0.25 9.8 31.9 0.28 9.7 0.8 2.6 2 0 0 2 2 2 0 Macoilin family Apt1 PF10351.9 CDI79654.1 - 0.54 9.0 26.5 0.75 8.6 0.8 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Histone PF00125.24 CDI79655.1 - 2e-20 73.5 0.4 2.4e-20 73.2 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDI79655.1 - 5.8e-05 23.3 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CDI79655.1 - 0.00082 19.8 0.0 0.0012 19.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A ATG_C PF09333.11 CDI79657.1 - 4.5e-08 33.3 0.0 4.5e-08 33.3 0.0 3.1 4 0 0 4 4 4 1 Autophagy-related protein C terminal domain DUF2722 PF10846.8 CDI79657.1 - 1.8 7.4 15.6 0.23 10.3 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) Nucleoporin_FG PF13634.6 CDI79658.1 - 0.016 16.1 26.9 0.016 16.1 26.9 16.1 3 3 14 17 17 17 0 Nucleoporin FG repeat region DUF4238 PF14022.6 CDI79658.1 - 0.12 11.9 0.9 0.21 11.0 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) PITH PF06201.13 CDI79659.1 - 1.5e-18 67.4 0.0 2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain Sad1_UNC PF07738.13 CDI79659.1 - 0.17 11.9 0.0 0.47 10.5 0.0 1.9 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal DEAD PF00270.29 CDI79661.1 - 1.7e-17 63.8 0.1 2.5e-17 63.2 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDI79661.1 - 0.0086 16.1 0.3 0.019 15.0 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Spt20 PF12090.8 CDI79661.1 - 0.42 10.2 8.1 0.62 9.6 8.1 1.2 1 0 0 1 1 1 0 Spt20 family THOC2_N PF16134.5 CDI79661.1 - 1.8 7.1 7.0 2.7 6.5 7.0 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF515 PF04415.12 CDI79661.1 - 7.2 4.9 11.5 0.21 9.9 2.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF515) Presenilin PF01080.17 CDI79662.1 - 0.0068 15.2 7.7 0.0092 14.8 7.7 1.2 1 0 0 1 1 1 1 Presenilin Spt20 PF12090.8 CDI79662.1 - 0.015 14.9 21.4 0.015 14.9 21.4 2.4 3 0 0 3 3 3 0 Spt20 family MTP18 PF10558.9 CDI79662.1 - 0.022 14.7 1.1 0.36 10.8 0.4 2.2 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF1635 PF07795.11 CDI79662.1 - 0.047 13.6 24.9 0.23 11.3 7.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) SID-1_RNA_chan PF13965.6 CDI79662.1 - 0.098 11.1 4.0 0.14 10.5 4.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EcsC PF12787.7 CDI79662.1 - 0.21 11.2 4.2 0.076 12.7 0.7 1.9 2 0 0 2 2 2 0 EcsC protein family DUF572 PF04502.13 CDI79662.1 - 0.63 9.6 12.0 0.97 9.0 12.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SR-25 PF10500.9 CDI79662.1 - 0.67 9.5 35.7 0.59 9.7 15.7 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 CDI79662.1 - 1.3 9.2 16.6 1.9 8.6 16.6 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 CDI79662.1 - 2.3 7.1 9.4 3.6 6.5 9.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 CDI79662.1 - 2.5 7.7 9.1 0.34 10.6 3.7 1.9 2 0 0 2 2 2 0 FAM176 family CDK2AP PF09806.9 CDI79662.1 - 4.4 7.3 31.6 1.2 9.2 6.0 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein PNISR PF15996.5 CDI79662.1 - 6.2 7.0 14.7 1.5 9.0 7.7 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DEAD PF00270.29 CDI79663.1 - 3.1e-23 82.4 2.7 3.1e-23 82.4 2.7 4.0 3 1 1 4 4 4 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79663.1 - 2.6e-16 60.0 0.2 5.7e-14 52.4 0.0 3.8 2 1 1 3 3 3 1 Helicase conserved C-terminal domain RPN2_C PF18004.1 CDI79663.1 - 0.004 17.1 1.3 0.004 17.1 1.3 7.1 4 2 1 5 5 5 1 26S proteasome regulatory subunit RPN2 C-terminal domain Phage_integrase PF00589.22 CDI79665.1 - 2.3e-11 43.8 0.0 6e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Phage integrase family DZR PF12773.7 CDI79665.1 - 5.2e-05 23.2 0.5 0.00013 21.9 0.5 1.6 1 0 0 1 1 1 1 Double zinc ribbon SAP PF02037.27 CDI79665.1 - 6.2e-05 22.6 0.6 0.00016 21.3 0.6 1.7 1 0 0 1 1 1 1 SAP domain zinc_ribbon_2 PF13240.6 CDI79665.1 - 0.00015 21.4 1.0 0.0004 20.0 1.0 1.8 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 CDI79665.1 - 0.0003 21.5 0.4 0.0011 19.7 0.4 2.0 1 0 0 1 1 1 1 zinc-ribbon family PLATZ PF04640.14 CDI79665.1 - 0.0044 17.6 0.6 0.01 16.5 0.6 1.6 1 0 0 1 1 1 1 PLATZ transcription factor UPF0547 PF10571.9 CDI79665.1 - 0.097 12.8 2.1 0.26 11.4 2.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 DEAD PF00270.29 CDI79666.1 - 4.3e-30 104.8 0.3 4.3e-30 104.8 0.3 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79666.1 - 1.9e-20 73.2 0.0 5.9e-20 71.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI79666.1 - 0.0014 18.6 0.4 0.0068 16.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDI79666.1 - 0.0085 16.4 0.2 0.076 13.3 0.2 2.6 1 1 0 1 1 1 1 AAA domain SIS PF01380.22 CDI79666.1 - 0.067 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 SIS domain DARPP-32 PF05395.12 CDI79666.1 - 0.16 12.2 11.7 0.022 15.0 3.0 2.7 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 DUF2722 PF10846.8 CDI79667.1 - 7.6e-07 28.4 59.0 0.027 13.4 3.7 4.6 4 0 0 4 4 4 4 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI79667.1 - 0.00061 19.5 85.7 0.29 10.7 17.9 4.7 4 0 0 4 4 4 4 Spt20 family MRNIP PF15749.5 CDI79667.1 - 0.61 10.8 38.7 1.7 9.4 4.4 5.0 4 0 0 4 4 4 0 MRN-interacting protein Surface_antigen PF11054.8 CDI79668.1 - 1.7e-101 339.0 1.4 1.7e-101 339.0 1.4 1.9 2 0 0 2 2 2 1 Sporozoite TA4 surface antigen TssN PF17555.2 CDI79668.1 - 2.1 7.7 3.1 2.3 7.5 1.5 1.7 2 0 0 2 2 2 0 Type VI secretion system, TssN Surface_antigen PF11054.8 CDI79669.1 - 2e-114 381.4 5.1 2.2e-114 381.2 5.1 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI79670.1 - 9.3e-66 222.0 5.6 1.2e-65 221.6 5.6 1.1 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI79671.1 - 1.6e-118 394.7 0.6 1.8e-118 394.5 0.6 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI79672.1 - 1.8e-78 263.6 4.9 2e-78 263.4 4.9 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen GCD14 PF08704.10 CDI79673.1 - 7.8e-65 219.0 0.0 2.8e-41 141.8 0.0 2.4 2 1 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 CDI79673.1 - 1.4e-05 24.9 0.0 0.00011 22.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDI79673.1 - 0.00074 19.3 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CDI79673.1 - 0.022 15.4 0.0 0.053 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CDI79673.1 - 0.22 11.1 0.0 1.4 8.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Surface_antigen PF11054.8 CDI79674.1 - 3.7e-111 370.6 0.1 4.2e-111 370.4 0.1 1.0 1 0 0 1 1 1 1 Sporozoite TA4 surface antigen ABC_tran PF00005.27 CDI79675.1 - 5.5e-33 114.4 0.0 1e-32 113.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDI79675.1 - 3.1e-24 86.1 6.9 4.4e-24 85.6 6.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDI79675.1 - 5e-05 22.8 0.0 0.0026 17.2 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDI79675.1 - 0.00013 21.9 0.1 0.0072 16.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDI79675.1 - 0.00021 21.7 0.7 0.00073 20.0 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDI79675.1 - 0.0035 17.6 0.2 0.033 14.5 0.0 2.6 4 0 0 4 4 3 1 AAA domain Zeta_toxin PF06414.12 CDI79675.1 - 0.004 16.4 0.0 0.0085 15.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 CDI79675.1 - 0.013 15.2 0.0 0.039 13.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 CDI79675.1 - 0.026 14.9 0.0 0.3 11.5 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDI79675.1 - 0.042 13.0 0.0 0.072 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 CDI79675.1 - 0.046 13.6 0.0 0.16 11.9 0.0 2.0 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 CDI79675.1 - 0.088 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDI79675.1 - 0.11 12.3 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 CDI79675.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 CDI79675.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 CDI79675.1 - 0.15 12.6 0.0 0.51 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain DLIC PF05783.11 CDI79675.1 - 0.21 10.4 0.0 0.36 9.6 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Pox_A32 PF04665.12 CDI79675.1 - 0.21 11.0 0.0 0.41 10.0 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_15 PF13175.6 CDI79675.1 - 0.23 11.2 0.0 0.33 10.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain YbgS PF13985.6 CDI79675.1 - 2.4 8.5 4.4 5.1 7.4 4.4 1.5 1 0 0 1 1 1 0 YbgS-like protein ATP-synt_S1 PF05827.12 CDI79676.1 - 0.0038 17.1 0.7 0.0049 16.7 0.5 1.2 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) TMEM52 PF14979.6 CDI79676.1 - 0.12 12.3 2.7 0.11 12.4 1.5 1.5 1 1 1 2 2 2 0 Transmembrane 52 TMIE PF16038.5 CDI79676.1 - 0.22 11.4 0.3 0.22 11.4 0.3 1.6 2 0 0 2 2 2 0 TMIE protein L51_S25_CI-B8 PF05047.16 CDI79677.1 - 0.00024 20.9 0.0 0.00048 20.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Pkinase PF00069.25 CDI79679.1 - 8.6e-65 218.7 0.0 1.1e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79679.1 - 1.4e-29 103.1 0.0 2.1e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDI79679.1 - 0.00055 19.0 0.4 0.00055 19.0 0.4 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 CDI79679.1 - 0.028 13.8 0.1 0.18 11.1 0.0 2.1 2 1 1 3 3 3 0 Kinase-like APH PF01636.23 CDI79679.1 - 0.037 13.9 0.1 2.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family TTL PF03133.15 CDI79681.1 - 1e-48 166.0 0.1 1e-48 166.0 0.1 4.1 4 0 0 4 4 4 1 Tubulin-tyrosine ligase family EF-hand_4 PF12763.7 CDI79682.1 - 6.9e-09 35.6 0.0 1.2e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SUIM_assoc PF16619.5 CDI79682.1 - 0.00016 21.6 0.2 0.00024 21.1 0.2 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 EF-hand_7 PF13499.6 CDI79682.1 - 0.011 16.2 0.0 0.018 15.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 CDI79682.1 - 0.17 11.5 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 EF hand SUIM_assoc PF16619.5 CDI79684.1 - 4.2e-05 23.5 4.5 4.2e-05 23.5 4.5 2.6 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Lin-8 PF03353.15 CDI79684.1 - 0.8 9.2 6.2 0.11 12.1 1.4 1.9 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Ribosomal_L37 PF08561.10 CDI79685.1 - 1.5e-08 35.2 0.0 1.5e-08 35.2 0.0 5.5 2 2 1 3 3 3 1 Mitochondrial ribosomal protein L37 DUF755 PF05501.11 CDI79685.1 - 0.015 15.5 5.5 0.015 15.5 5.5 6.9 6 1 0 6 6 6 0 Domain of unknown function (DUF755) AP2 PF00847.20 CDI79686.1 - 0.0014 18.8 3.7 0.0014 18.8 3.7 2.5 2 0 0 2 2 2 1 AP2 domain Bromodomain PF00439.25 CDI79687.1 - 2.3e-16 59.6 0.0 3.6e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain AF-4 PF05110.13 CDI79687.1 - 0.00087 17.5 7.3 0.00087 17.5 7.3 6.4 4 2 0 6 6 6 1 AF-4 proto-oncoprotein MIF4G PF02854.19 CDI79688.1 - 1.5e-27 96.6 2.6 3e-27 95.7 2.6 1.5 1 0 0 1 1 1 1 MIF4G domain DUF2938 PF11158.8 CDI79689.1 - 0.046 13.2 2.1 0.097 12.1 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2938) DUF986 PF06173.12 CDI79689.1 - 0.66 10.0 2.9 1.1 9.3 2.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF986) DUF515 PF04415.12 CDI79689.1 - 3.1 6.1 10.9 4.2 5.6 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) SLC12 PF03522.15 CDI79690.1 - 0.0081 15.2 17.5 0.016 14.3 17.5 1.4 1 0 0 1 1 1 1 Solute carrier family 12 FAM222A PF15258.6 CDI79690.1 - 0.083 12.0 24.0 0.15 11.1 24.0 1.4 1 0 0 1 1 1 0 Protein family of FAM222A PAT1 PF09770.9 CDI79690.1 - 0.57 8.4 29.6 0.92 7.7 29.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MMR1 PF08505.10 CDI79690.1 - 0.67 10.2 22.9 1.6 9.0 22.9 1.6 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Borrelia_P83 PF05262.11 CDI79690.1 - 0.77 8.2 28.3 1.2 7.5 28.3 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein SID-1_RNA_chan PF13965.6 CDI79690.1 - 1.4 7.2 6.8 2.1 6.6 6.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 eIF-3_zeta PF05091.12 CDI79690.1 - 2.2 7.2 19.1 3.2 6.6 19.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF572 PF04502.13 CDI79690.1 - 2.2 7.8 26.7 5.1 6.6 26.7 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF572) Draxin PF15550.6 CDI79690.1 - 4.6 7.0 18.2 10 5.9 18.2 1.5 1 0 0 1 1 1 0 Draxin RR_TM4-6 PF06459.12 CDI79690.1 - 5.4 6.7 24.6 11 5.8 24.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 IBB PF01749.20 CDI79691.1 - 0.55 10.7 11.7 0.39 11.2 6.0 2.7 2 0 0 2 2 2 0 Importin beta binding domain Myb_DNA-bind_7 PF15963.5 CDI79692.1 - 1.8e-21 75.9 0.2 1.8e-21 75.9 0.2 2.7 3 0 0 3 3 3 1 Myb DNA-binding like HMG_box PF00505.19 CDI79692.1 - 1.6e-07 31.6 0.2 0.00033 21.0 0.1 3.0 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 CDI79692.1 - 4.3e-06 27.2 17.2 4.8e-06 27.1 0.7 3.8 3 1 0 3 3 3 2 HMG-box domain Myb_DNA-binding PF00249.31 CDI79692.1 - 0.033 14.4 0.1 0.083 13.1 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain PA PF02225.22 CDI79694.1 - 9.9e-06 25.5 0.0 1.9e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 PA domain DUF1422 PF07226.11 CDI79694.1 - 0.087 12.8 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1422) PspB PF06667.12 CDI79694.1 - 0.13 12.3 0.4 0.27 11.3 0.4 1.4 1 0 0 1 1 1 0 Phage shock protein B WD40 PF00400.32 CDI79695.1 - 2e-40 136.0 30.3 2.1e-09 37.8 0.1 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI79695.1 - 2.8e-10 40.4 1.3 0.37 11.1 0.0 4.8 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDI79695.1 - 2.1e-07 30.6 0.0 0.0002 20.8 0.0 2.6 2 1 1 3 3 3 3 WD40-like domain PQQ_3 PF13570.6 CDI79695.1 - 0.00012 22.5 0.5 0.012 16.1 0.0 3.4 3 1 0 3 3 3 1 PQQ-like domain Nup160 PF11715.8 CDI79695.1 - 0.041 12.5 11.9 0.12 11.0 0.3 4.0 1 1 2 4 4 4 0 Nucleoporin Nup120/160 Adeno_terminal PF02459.15 CDI79695.1 - 0.1 11.0 0.1 0.14 10.5 0.1 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Citrate_synt PF00285.21 CDI79696.1 - 4.2e-85 286.0 0.0 4.8e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF3040 PF11239.8 CDI79697.1 - 0.2 11.9 3.8 3.5 8.0 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) tRNA-synt_1 PF00133.22 CDI79698.1 - 9.4e-64 215.7 0.0 1.4e-41 142.5 0.0 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDI79698.1 - 2.9e-17 63.0 0.0 4.9e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDI79698.1 - 4.4e-07 29.0 0.0 2.5e-06 26.5 0.0 2.1 3 0 0 3 3 3 1 tRNA synthetases class I (M) DUF2012 PF09430.10 CDI79699.1 - 4.7e-10 39.6 0.0 7.5e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) DUF3149 PF11346.8 CDI79699.1 - 0.042 13.5 0.2 0.065 12.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) OTU PF02338.19 CDI79700.1 - 6.4e-10 39.6 0.0 1.3e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CDI79700.1 - 0.00036 20.1 0.1 0.023 14.2 0.1 2.2 1 1 1 2 2 2 2 Peptidase C65 Otubain MobA_MobL PF03389.15 CDI79700.1 - 0.055 13.2 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 MobA/MobL family VWA PF00092.28 CDI79701.1 - 2.2e-28 99.7 0.0 3e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain TSP_1 PF00090.19 CDI79701.1 - 1.8e-22 79.3 69.2 2.3e-09 37.3 3.5 7.2 6 2 0 6 6 6 5 Thrombospondin type 1 domain VWA_2 PF13519.6 CDI79701.1 - 5.3e-11 43.1 0.0 8.3e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 CDI79701.1 - 0.021 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF3689 PF12463.8 CDI79703.1 - 8.8e-28 97.5 16.5 1.6e-11 44.1 0.0 4.9 4 1 0 4 4 4 3 Protein of unknown function (DUF3689) SUIM_assoc PF16619.5 CDI79703.1 - 2e-06 27.8 1.4 2e-06 27.8 1.4 21.3 16 6 2 18 18 18 6 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI79703.1 - 1.3e-05 24.9 15.3 1.3e-05 24.9 15.3 21.9 15 6 6 23 23 23 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 CDI79703.1 - 1.6e-05 23.7 25.9 1.6e-05 23.7 25.9 12.6 8 3 1 11 11 11 3 Macoilin family BUD22 PF09073.10 CDI79703.1 - 0.038 13.3 0.0 0.038 13.3 0.0 12.1 9 4 2 11 11 11 0 BUD22 RRM_1 PF00076.22 CDI79704.1 - 4.8e-22 77.6 0.0 6.2e-10 38.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI79704.1 - 0.00013 21.7 0.2 0.00074 19.3 0.0 2.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif Spt20 PF12090.8 CDI79704.1 - 0.00047 19.8 16.4 0.00087 19.0 16.4 1.5 1 0 0 1 1 1 1 Spt20 family Nop53 PF07767.11 CDI79704.1 - 0.0046 16.4 9.3 0.0068 15.9 9.3 1.3 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) TM1506 PF08973.10 CDI79704.1 - 0.059 13.0 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) RR_TM4-6 PF06459.12 CDI79704.1 - 0.2 11.5 12.4 0.27 11.0 12.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI79704.1 - 0.25 11.3 5.7 0.31 11.1 5.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 CDI79704.1 - 0.25 11.3 26.1 0.38 10.7 26.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2464 PF10240.9 CDI79704.1 - 0.26 10.8 2.7 0.37 10.3 2.7 1.4 1 0 0 1 1 1 0 Multivesicular body subunit 12 PHM7_cyt PF14703.6 CDI79704.1 - 0.32 11.2 6.2 0.6 10.3 5.2 2.0 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter eIF-3_zeta PF05091.12 CDI79704.1 - 0.56 9.1 10.3 0.69 8.8 10.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Lin-8 PF03353.15 CDI79704.1 - 1.1 8.8 15.2 1.5 8.3 15.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Plasmodium_Vir PF05795.11 CDI79704.1 - 1.6 8.1 5.5 1.9 7.8 5.5 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Hid1 PF12722.7 CDI79704.1 - 1.8 6.6 8.9 2.1 6.4 8.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TERB2 PF15101.6 CDI79704.1 - 2.7 8.0 13.7 6.1 6.8 13.7 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Zip PF02535.22 CDI79704.1 - 3.2 6.9 8.5 4.3 6.4 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 CDI79704.1 - 3.7 7.3 9.9 6.3 6.5 9.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Paf1 PF03985.13 CDI79704.1 - 4 6.3 19.2 6.8 5.6 19.2 1.3 1 0 0 1 1 1 0 Paf1 Presenilin PF01080.17 CDI79704.1 - 4.3 6.0 16.3 6.7 5.4 16.3 1.2 1 0 0 1 1 1 0 Presenilin THOC7 PF05615.13 CDI79704.1 - 5.1 7.4 18.6 3.7 7.8 15.0 2.2 2 1 0 2 2 2 0 Tho complex subunit 7 Slu7 PF11708.8 CDI79704.1 - 5.5 6.7 17.3 1 9.0 13.3 1.7 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor EMC3_TMCO1 PF01956.16 CDI79704.1 - 5.7 6.6 5.8 11 5.7 5.8 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like CLN3 PF02487.17 CDI79704.1 - 7.3 5.5 6.4 11 4.9 6.4 1.2 1 0 0 1 1 1 0 CLN3 protein Coilin_N PF15862.5 CDI79704.1 - 9.3 6.1 12.4 5.7 6.7 9.9 2.0 2 0 0 2 2 2 0 Coilin N-terminus NPR3 PF03666.13 CDI79704.1 - 9.3 4.9 14.7 3.4 6.3 10.0 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 RIC3 PF15361.6 CDI79705.1 - 0.068 13.6 2.2 0.068 13.6 2.2 2.0 2 1 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 FliP PF00813.20 CDI79705.1 - 0.43 10.4 2.6 0.61 9.9 2.6 1.2 1 0 0 1 1 1 0 FliP family RskA PF10099.9 CDI79705.1 - 1.8 8.8 16.5 0.64 10.3 2.1 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TMEM208_SND2 PF05620.11 CDI79705.1 - 3 7.6 6.9 5.6 6.7 6.9 1.4 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DivIC PF04977.15 CDI79705.1 - 4 7.3 17.7 5.6 6.8 17.7 1.2 1 0 0 1 1 1 0 Septum formation initiator WBP-1 PF11669.8 CDI79705.1 - 5.5 7.7 9.6 2.4 8.8 5.7 2.1 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF2722 PF10846.8 CDI79706.1 - 0.00046 19.3 1.2 0.00046 19.3 1.2 7.5 5 3 1 7 7 7 1 Protein of unknown function (DUF2722) RNase_Zc3h12a PF11977.8 CDI79707.1 - 5.6e-13 49.0 3.4 8.6e-08 32.1 0.0 3.7 3 2 0 3 3 3 2 Zc3h12a-like Ribonuclease NYN domain Utp14 PF04615.13 CDI79707.1 - 0.00023 19.9 44.6 0.00023 19.9 44.6 2.7 3 0 0 3 3 3 1 Utp14 protein DUF4667 PF15700.5 CDI79707.1 - 0.023 14.8 0.6 0.023 14.8 0.6 6.7 4 1 2 6 6 6 0 Domain of unknown function (DUF4667) Ribosomal_60s PF00428.19 CDI79707.1 - 4.5 7.9 13.2 23 5.7 6.3 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Velvet PF11754.8 CDI79708.1 - 0.051 13.5 2.3 0.062 13.2 2.3 1.2 1 0 0 1 1 1 0 Velvet factor Secretin_N_2 PF07655.13 CDI79708.1 - 0.06 13.9 16.9 0.16 12.6 16.9 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain TFIIA PF03153.13 CDI79708.1 - 0.15 12.0 4.5 0.18 11.8 4.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI79708.1 - 0.71 8.4 5.6 0.88 8.1 5.6 1.2 1 0 0 1 1 1 0 Macoilin family TAF4 PF05236.14 CDI79708.1 - 1.2 8.8 5.7 9.1 5.9 0.1 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family AF-4 PF05110.13 CDI79708.1 - 3.1 5.7 16.5 3.7 5.5 16.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 CDI79708.1 - 6.4 6.3 20.3 13 5.3 20.3 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UPF0051 PF01458.17 CDI79712.1 - 5.3e-43 147.2 0.1 1.1e-42 146.3 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) SUIM_assoc PF16619.5 CDI79712.1 - 0.0039 17.2 9.6 0.015 15.3 3.2 5.6 5 1 0 5 5 5 2 Unstructured region C-term to UIM in Ataxin3 TAF1D PF15333.6 CDI79712.1 - 0.024 14.4 0.6 0.024 14.4 0.6 2.4 3 0 0 3 3 3 0 TATA box-binding protein-associated factor 1D Sporozoite_P67 PF05642.11 CDI79713.1 - 0.00043 18.5 22.1 0.00043 18.5 22.1 2.3 2 0 0 2 2 2 2 Sporozoite P67 surface antigen RSRP PF17069.5 CDI79713.1 - 0.99 8.9 17.7 2.8 7.4 17.7 1.8 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Peptidase_S8 PF00082.22 CDI79714.1 - 1.7e-43 149.0 7.9 4.2e-43 147.7 7.9 1.6 1 0 0 1 1 1 1 Subtilase family LMBR1 PF04791.16 CDI79715.1 - 7.2e-10 38.4 0.1 1.9e-09 37.0 0.0 1.7 2 1 0 2 2 2 1 LMBR1-like membrane protein DUF2569 PF10754.9 CDI79715.1 - 0.06 13.8 6.6 0.23 11.9 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2569) DUF1980 PF09323.10 CDI79715.1 - 0.32 10.9 1.6 0.7 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF1180 PF06679.12 CDI79715.1 - 0.46 10.9 14.2 0.081 13.3 1.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) Sec20 PF03908.13 CDI79716.1 - 0.00017 21.4 7.8 0.14 12.1 0.4 2.9 2 0 0 2 2 2 2 Sec20 LcrG PF07216.12 CDI79716.1 - 0.19 11.7 2.3 0.58 10.1 2.3 1.8 1 0 0 1 1 1 0 LcrG protein HupE_UreJ_2 PF13795.6 CDI79716.1 - 0.38 10.4 2.2 0.88 9.2 2.2 1.6 1 0 0 1 1 1 0 HupE / UreJ protein FliD_C PF07195.12 CDI79716.1 - 6.7 6.1 6.5 0.76 9.1 0.3 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Muted PF14942.6 CDI79716.1 - 9.9 6.5 8.4 6.1 7.2 1.0 2.6 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ABC_tran PF00005.27 CDI79717.1 - 1.5e-23 83.8 0.1 2.4e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CDI79717.1 - 1.7e-12 47.2 3.5 7.6e-10 38.6 3.5 2.6 1 1 0 1 1 1 1 ABC-2 type transporter RsgA_GTPase PF03193.16 CDI79717.1 - 8.4e-05 22.5 0.1 0.00015 21.7 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDI79717.1 - 0.00018 21.9 0.1 0.00031 21.1 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CDI79717.1 - 0.00018 21.4 0.1 0.11 12.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CDI79717.1 - 0.0005 19.7 0.1 0.0011 18.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI79717.1 - 0.00061 19.5 0.3 0.0016 18.1 0.3 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CDI79717.1 - 0.002 18.7 0.0 0.0056 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDI79717.1 - 0.0082 16.2 0.7 0.015 15.3 0.7 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF87 PF01935.17 CDI79717.1 - 0.014 15.5 0.6 0.026 14.6 0.6 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain IstB_IS21 PF01695.17 CDI79717.1 - 0.023 14.4 0.1 0.064 13.0 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 CDI79717.1 - 0.051 12.8 0.1 0.09 12.0 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 CDI79717.1 - 0.057 13.7 0.1 0.099 12.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDI79717.1 - 0.071 12.8 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CDI79717.1 - 0.087 11.8 0.2 0.18 10.8 0.2 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 CDI79717.1 - 0.1 12.5 0.1 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_22 PF13401.6 CDI79717.1 - 0.17 12.2 0.2 0.44 10.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain DEAD PF00270.29 CDI79719.1 - 1.1e-33 116.4 0.0 5.3e-24 84.9 0.0 2.6 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI79719.1 - 1e-23 83.8 0.0 2e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI79719.1 - 0.0011 19.0 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDI79719.1 - 0.045 14.0 0.0 9.7 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain Peptidase_M41 PF01434.18 CDI79720.1 - 1.3e-45 155.6 1.4 1.5e-38 132.6 0.0 3.3 3 0 0 3 3 3 2 Peptidase family M41 AAA PF00004.29 CDI79720.1 - 1.1e-41 142.4 0.0 2.5e-41 141.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 CDI79720.1 - 0.00036 19.8 0.0 0.00069 18.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 CDI79720.1 - 0.0014 18.6 0.1 0.0096 15.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDI79720.1 - 0.0016 18.7 2.3 0.14 12.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CDI79720.1 - 0.0032 18.0 0.0 0.0086 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI79720.1 - 0.0067 16.8 0.2 0.0067 16.8 0.2 3.8 5 1 0 5 5 4 1 AAA ATPase domain RuvB_N PF05496.12 CDI79720.1 - 0.0082 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CDI79720.1 - 0.024 14.8 0.0 0.067 13.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDI79720.1 - 0.03 14.1 0.0 0.075 12.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 CDI79720.1 - 0.047 14.1 0.0 0.23 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 CDI79720.1 - 0.12 12.5 0.0 0.43 10.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CDI79720.1 - 0.27 11.5 0.0 0.27 11.5 0.0 2.8 4 1 0 4 4 2 0 AAA domain Mg_chelatase PF01078.21 CDI79720.1 - 0.54 9.6 4.0 0.13 11.6 0.2 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI S-antigen PF05756.11 CDI79720.1 - 6.2 7.3 9.3 17 5.8 9.3 1.8 1 0 0 1 1 1 0 S-antigen protein TFIIA PF03153.13 CDI79723.1 - 0.0016 18.5 8.1 0.0016 18.5 8.1 7.8 3 1 4 7 7 7 2 Transcription factor IIA, alpha/beta subunit HNOBA PF07701.14 CDI79723.1 - 0.51 9.7 0.0 0.51 9.7 0.0 4.5 3 1 0 3 3 3 0 Heme NO binding associated DDHD PF02862.17 CDI79724.1 - 0.038 14.2 3.7 0.039 14.1 3.7 1.2 1 0 0 1 1 1 0 DDHD domain BAF1_ABF1 PF04684.13 CDI79724.1 - 0.15 11.1 8.7 0.21 10.6 8.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Macoilin PF09726.9 CDI79724.1 - 0.32 9.5 8.5 0.38 9.3 8.5 1.1 1 0 0 1 1 1 0 Macoilin family DAAD PF18752.1 CDI79724.1 - 0.63 9.8 8.6 0.9 9.3 8.6 1.1 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase Sec62 PF03839.16 CDI79724.1 - 0.71 9.3 4.5 1.1 8.7 4.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 CDI79724.1 - 0.83 8.4 10.5 0.95 8.2 10.5 1.2 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI79724.1 - 1.1 7.5 15.0 1.2 7.3 15.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Zip PF02535.22 CDI79724.1 - 4.6 6.4 5.0 4.5 6.4 5.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 CDI79724.1 - 6.2 3.8 11.2 7.4 3.5 11.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TERB2 PF15101.6 CDI79724.1 - 6.6 6.7 14.0 9.4 6.2 14.0 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CAML PF14963.6 CDI79724.1 - 8.7 6.4 6.6 7.2 6.7 2.6 2.1 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Macro PF01661.21 CDI79725.1 - 0.0026 17.8 0.2 0.011 15.8 0.0 2.1 2 1 0 2 2 2 1 Macro domain DUF2722 PF10846.8 CDI79725.1 - 0.0049 15.9 7.3 0.0065 15.5 7.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI79725.1 - 1.9 8.4 17.5 2.1 8.3 16.6 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit R3H-assoc PF13902.6 CDI79725.1 - 2.4 8.6 7.8 1.2 9.6 2.6 2.1 2 0 0 2 2 2 0 R3H-associated N-terminal domain Nop16 PF09420.10 CDI79726.1 - 3.5e-10 40.3 0.2 3.5e-10 40.3 0.2 2.5 2 1 0 2 2 1 1 Ribosome biogenesis protein Nop16 Myb_DNA-bind_4 PF13837.6 CDI79726.1 - 0.01 16.2 0.7 0.021 15.2 0.7 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain CDC45 PF02724.14 CDI79726.1 - 0.13 10.5 12.4 0.14 10.5 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SRP-alpha_N PF04086.13 CDI79726.1 - 0.48 10.3 19.3 0.53 10.2 19.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SPX PF03105.19 CDI79726.1 - 1.4 8.8 26.5 1.4 8.7 26.5 1.1 1 0 0 1 1 1 0 SPX domain rRNA_processing PF08524.11 CDI79726.1 - 2.8 7.9 10.1 7.1 6.6 10.1 1.8 1 1 0 1 1 1 0 rRNA processing Presenilin PF01080.17 CDI79726.1 - 3.4 6.3 17.6 3.3 6.4 17.6 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI79726.1 - 3.5 6.4 30.1 3.8 6.2 30.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peroxin-3 PF04882.12 CDI79726.1 - 6.1 5.7 20.3 6.5 5.6 20.3 1.1 1 0 0 1 1 1 0 Peroxin-3 GEMIN8 PF15348.6 CDI79726.1 - 6.3 7.0 15.4 8.8 6.6 15.4 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 SpoIIIAH PF12685.7 CDI79726.1 - 6.8 6.4 17.8 8 6.2 17.8 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein CobT PF06213.12 CDI79726.1 - 8.2 5.7 12.2 9.9 5.5 12.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nucleo_P87 PF07267.11 CDI79726.1 - 9.1 5.0 9.5 12 4.6 9.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF5521 PF17659.1 CDI79726.1 - 9.5 3.9 12.4 9.7 3.9 12.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) RRM_1 PF00076.22 CDI79727.1 - 1.3e-35 121.1 0.5 4.2e-17 61.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI79727.1 - 6.3e-11 42.3 0.0 0.00045 20.3 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDI79727.1 - 0.00014 21.7 0.0 0.053 13.5 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF2722 PF10846.8 CDI79727.1 - 0.00023 20.3 6.7 0.00023 20.3 6.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI79727.1 - 0.00032 20.8 12.6 0.00038 20.6 12.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RRM_3 PF08777.11 CDI79727.1 - 0.0012 18.9 4.4 0.16 12.1 0.0 3.2 3 0 0 3 3 3 2 RNA binding motif Presenilin PF01080.17 CDI79727.1 - 0.072 11.9 5.4 0.089 11.5 5.4 1.3 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI79727.1 - 0.27 11.0 1.0 0.39 10.4 1.0 1.3 1 0 0 1 1 1 0 Connexin RAB3GAP2_N PF14655.6 CDI79727.1 - 0.3 10.3 5.2 0.5 9.6 5.2 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Peptidase_S49_N PF08496.10 CDI79727.1 - 0.31 11.1 2.7 0.4 10.7 1.6 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF1387 PF07139.11 CDI79727.1 - 0.45 10.2 7.3 0.82 9.3 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CPSF100_C PF13299.6 CDI79727.1 - 0.48 10.6 5.3 1.1 9.4 5.3 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4698 PF15769.5 CDI79727.1 - 0.51 9.3 6.5 0.77 8.8 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) RED_N PF07808.13 CDI79727.1 - 0.63 9.6 9.5 1.5 8.4 9.5 1.6 1 0 0 1 1 1 0 RED-like protein N-terminal region CCDC53 PF10152.9 CDI79727.1 - 0.71 10.3 9.2 0.96 9.9 7.6 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Neur_chan_memb PF02932.16 CDI79727.1 - 1.3 9.0 3.6 12 5.9 3.9 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Med15 PF09606.10 CDI79727.1 - 1.9 7.1 23.0 2.9 6.5 23.0 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4407 PF14362.6 CDI79727.1 - 4 6.7 10.3 7.6 5.8 10.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 CDI79727.1 - 5.1 4.9 6.8 7.2 4.4 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI79727.1 - 5.3 6.8 9.7 3.3 7.4 7.6 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 BRF1 PF07741.13 CDI79727.1 - 9.1 6.7 11.5 0.77 10.1 5.7 2.2 3 0 0 3 3 2 0 Brf1-like TBP-binding domain SAWADEE PF16719.5 CDI79730.1 - 0.0015 18.6 1.1 0.0035 17.4 0.1 2.1 3 0 0 3 3 3 1 SAWADEE domain XRN_M PF17846.1 CDI79730.1 - 0.37 9.7 6.8 0.45 9.4 1.7 2.1 2 0 0 2 2 2 0 Xrn1 helical domain GCD14 PF08704.10 CDI79730.1 - 2 8.0 5.2 8.8 5.9 0.1 2.1 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Pkinase PF00069.25 CDI79731.1 - 9.7e-21 74.3 0.0 1.4e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79731.1 - 4.5e-11 42.5 0.0 6.3e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI79731.1 - 3.9e-07 29.2 0.0 5.5e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI79731.1 - 0.00048 20.1 12.0 0.0042 17.0 0.2 3.5 3 1 1 4 4 4 2 Phosphotransferase enzyme family Kdo PF06293.14 CDI79731.1 - 0.0081 15.5 0.2 0.024 14.0 0.2 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_1 PF00515.28 CDI79732.1 - 7.5e-62 202.8 33.3 1.2e-08 34.4 0.0 9.3 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 CDI79732.1 - 3.4e-53 173.5 28.8 2.5e-06 27.2 0.0 9.3 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 CDI79732.1 - 5.9e-33 112.3 15.6 7.3e-06 25.6 0.0 8.4 5 2 3 8 8 8 7 TPR repeat TPR_8 PF13181.6 CDI79732.1 - 6.8e-32 107.0 27.5 0.00015 21.7 0.0 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 CDI79732.1 - 2.3e-26 91.9 13.0 6.5e-13 48.8 0.7 6.9 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDI79732.1 - 1.1e-24 86.8 4.8 0.00042 20.9 0.0 6.5 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDI79732.1 - 2.4e-22 77.7 7.9 0.0039 17.9 0.1 9.4 4 3 4 9 9 9 4 Tetratricopeptide repeat STI1 PF17830.1 CDI79732.1 - 8.3e-21 73.7 7.2 7.5e-14 51.4 4.0 3.4 2 1 0 2 2 2 2 STI1 domain TPR_17 PF13431.6 CDI79732.1 - 1.5e-20 72.0 17.6 0.011 16.1 0.0 8.7 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 CDI79732.1 - 1.3e-18 66.9 0.9 0.00028 20.9 0.0 7.3 2 2 3 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDI79732.1 - 6.8e-18 65.0 11.8 0.0035 17.8 0.0 6.7 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 CDI79732.1 - 4.1e-16 58.3 10.1 0.26 11.2 0.7 8.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 CDI79732.1 - 2e-14 52.5 10.1 0.0011 18.9 0.1 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI79732.1 - 5e-07 29.7 16.8 0.96 9.6 0.0 7.5 6 1 1 7 7 7 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 CDI79732.1 - 6.4e-06 26.3 18.8 0.041 14.1 3.6 4.9 2 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDI79732.1 - 0.00015 22.1 16.3 4.5 8.1 0.3 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat NARP1 PF12569.8 CDI79732.1 - 0.00017 20.6 27.2 0.00076 18.5 0.2 4.7 2 1 2 5 5 5 3 NMDA receptor-regulated protein 1 DUF3856 PF12968.7 CDI79732.1 - 0.00039 20.5 10.6 1.2 9.2 0.2 4.7 3 3 0 3 3 3 2 Domain of Unknown Function (DUF3856) ChAPs PF09295.10 CDI79732.1 - 0.0052 15.8 4.3 0.53 9.2 0.0 3.1 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_22 PF18833.1 CDI79732.1 - 0.13 12.4 0.5 6.9 6.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 CDI79732.1 - 0.21 11.9 10.2 0.89 10.0 0.2 5.2 7 0 0 7 7 4 0 PPR repeat Chlamy_scaf PF09675.10 CDI79732.1 - 0.26 11.7 3.9 9.8 6.6 0.0 4.5 3 2 1 4 4 4 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Casein PF00363.18 CDI79732.1 - 0.36 11.2 0.1 0.36 11.2 0.1 3.1 3 0 0 3 3 2 0 Casein DUF627 PF04781.12 CDI79732.1 - 0.48 10.4 7.6 5.6 7.0 1.0 4.1 4 0 0 4 4 3 0 Protein of unknown function (DUF627) DUF5113 PF17140.4 CDI79732.1 - 0.8 9.5 10.7 1.1 9.0 6.1 3.4 3 2 1 4 4 4 0 Domain of unknown function (DUF5113) XPC-binding PF09280.11 CDI79732.1 - 1 9.2 8.1 2.5 7.9 2.1 3.1 2 1 0 2 2 2 0 XPC-binding domain SHNi-TPR PF10516.9 CDI79732.1 - 1.3 8.5 8.1 14 5.2 0.0 5.3 6 0 0 6 6 6 0 SHNi-TPR TPR_20 PF14561.6 CDI79732.1 - 1.6 9.1 8.5 4.4 7.7 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat DnaI_N PF07319.11 CDI79732.1 - 2 9.2 16.0 0.14 12.9 1.3 4.6 5 0 0 5 5 4 0 Primosomal protein DnaI N-terminus HemY_N PF07219.13 CDI79732.1 - 3.5 7.9 8.5 3.7 7.8 0.2 3.7 3 0 0 3 3 3 0 HemY protein N-terminus PAM2 PF07145.15 CDI79734.1 - 0.071 12.8 3.5 0.18 11.5 3.5 1.7 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Helicase_C_2 PF13307.6 CDI79735.1 - 6.5e-38 130.6 0.8 1e-34 120.1 0.0 3.2 3 0 0 3 3 3 2 Helicase C-terminal domain DEAD_2 PF06733.15 CDI79735.1 - 1.4e-30 106.2 0.5 3.2e-30 105.1 0.0 1.9 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 CDI79735.1 - 0.022 14.5 0.3 0.13 12.0 0.0 2.4 3 0 0 3 3 3 0 DEAD/DEAH box helicase ApoLp-III PF07464.11 CDI79737.1 - 0.098 12.7 0.3 0.098 12.7 0.3 3.1 4 0 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Snapin_Pallidin PF14712.6 CDI79737.1 - 1.6 9.2 5.6 5.2 7.6 0.1 3.8 4 0 0 4 4 4 0 Snapin/Pallidin IncFII_repA PF02387.15 CDI79739.1 - 0.055 12.7 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 IncFII RepA protein family OmpH PF03938.14 CDI79739.1 - 4.8 7.5 11.0 53 4.1 0.0 3.7 3 1 1 4 4 4 0 Outer membrane protein (OmpH-like) ASFV_J13L PF05568.11 CDI79741.1 - 2.9 7.6 7.0 1.8 8.3 1.1 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein NOT2_3_5 PF04153.18 CDI79742.1 - 5.5e-15 55.6 2.4 5.5e-15 55.6 2.4 3.0 2 1 0 2 2 2 1 NOT2 / NOT3 / NOT5 family SRP-alpha_N PF04086.13 CDI79742.1 - 0.15 12.0 9.6 6.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DUF3835 PF12927.7 CDI79742.1 - 0.72 10.8 7.9 1.9 9.4 7.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3835) PAT1 PF09770.9 CDI79742.1 - 7.1 4.8 22.5 13 3.9 22.5 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EphA2_TM PF14575.6 CDI79742.1 - 9.1 7.2 5.7 3.1e+02 2.3 3.8 3.6 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain RskA PF10099.9 CDI79743.1 - 0.0021 18.4 61.0 0.0048 17.2 7.8 4.9 2 1 2 4 4 4 2 Anti-sigma-K factor rskA Tom37_C PF11801.8 CDI79743.1 - 0.0025 17.8 0.4 0.0025 17.8 0.4 3.8 5 0 0 5 5 5 1 Tom37 C-terminal domain DUF2722 PF10846.8 CDI79743.1 - 0.0097 14.9 49.1 0.059 12.3 3.1 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI79743.1 - 0.11 13.4 23.5 0.047 14.7 4.1 4.5 5 0 0 5 5 4 0 Domain of unknown function (DUF4834) DUF2116 PF09889.9 CDI79743.1 - 0.14 12.2 0.1 0.14 12.2 0.1 4.1 4 1 0 4 4 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) CSG2 PF16965.5 CDI79743.1 - 0.18 10.7 0.8 0.55 9.1 0.1 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator WBP-1 PF11669.8 CDI79743.1 - 0.36 11.5 8.9 1.6 9.4 0.1 4.0 4 0 0 4 4 4 0 WW domain-binding protein 1 BHD_2 PF10404.9 CDI79743.1 - 0.71 10.9 12.2 3.3 8.7 2.5 3.6 3 0 0 3 3 3 0 Rad4 beta-hairpin domain 2 EOS1 PF12326.8 CDI79743.1 - 1.2 9.1 6.5 1 9.2 0.4 2.9 3 0 0 3 3 3 0 N-glycosylation protein EphA2_TM PF14575.6 CDI79743.1 - 3.3 8.6 12.2 60 4.6 0.1 4.3 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Connexin PF00029.19 CDI79743.1 - 4.2 7.1 7.1 1.4 8.6 0.7 2.9 4 0 0 4 4 4 0 Connexin FAM176 PF14851.6 CDI79743.1 - 6.6 6.4 8.5 1.1 9.0 0.7 3.0 3 0 0 3 3 3 0 FAM176 family DUF2722 PF10846.8 CDI79744.1 - 0.00031 19.8 7.4 0.00031 19.8 7.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) ATP12 PF07542.11 CDI79744.1 - 0.0034 17.4 11.8 0.0034 17.4 11.8 3.2 2 1 0 2 2 2 1 ATP12 chaperone protein CAF1 PF04857.20 CDI79744.1 - 0.019 14.2 0.4 0.021 14.0 0.4 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Band_3_cyto PF07565.13 CDI79744.1 - 0.18 11.6 9.9 0.1 12.4 6.3 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain HisKA PF00512.25 CDI79744.1 - 0.32 11.0 4.0 0.41 10.7 1.9 2.3 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain V_ATPase_I PF01496.19 CDI79744.1 - 0.56 8.1 6.5 0.82 7.5 6.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4457 PF14652.6 CDI79744.1 - 0.68 9.1 5.0 1 8.6 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) MAT1 PF06391.13 CDI79744.1 - 2 8.2 15.6 0.29 11.0 9.7 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Rsc14 PF08586.10 CDI79744.1 - 3.4 8.5 7.0 1.1 10.0 3.0 2.1 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit YTH PF04146.15 CDI79745.1 - 1.7e-13 50.8 9.3 1.7e-13 50.8 9.3 2.6 2 1 0 2 2 2 1 YT521-B-like domain DASH_Spc19 PF08287.11 CDI79745.1 - 0.0011 18.9 0.7 0.0011 18.9 0.7 3.1 3 1 0 3 3 3 1 Spc19 EBP50_C PF09007.11 CDI79745.1 - 0.013 16.5 4.6 0.013 16.5 4.6 4.1 3 1 0 3 3 3 0 EBP50, C-terminal Bul1_C PF04426.12 CDI79745.1 - 9 5.6 13.2 0.47 9.8 1.3 2.3 2 0 0 2 2 2 0 Bul1 C terminus DUF668 PF05003.12 CDI79750.1 - 5.2 7.6 20.3 1.8 9.1 3.3 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF668) HTH_38 PF13936.6 CDI79751.1 - 1e-05 25.2 2.7 1e-05 25.2 2.7 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDI79751.1 - 1.4e-05 24.8 1.6 1.4e-05 24.8 1.6 2.1 2 0 0 2 2 2 1 Homeodomain-like domain DUF2722 PF10846.8 CDI79751.1 - 0.00041 19.4 4.0 0.00041 19.4 4.0 11.0 4 3 2 7 7 7 1 Protein of unknown function (DUF2722) Sigma70_r4_2 PF08281.12 CDI79751.1 - 0.00069 19.2 0.2 0.00069 19.2 0.2 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 Spt20 PF12090.8 CDI79751.1 - 0.0051 16.5 10.6 0.0051 16.5 10.6 11.2 4 3 4 8 8 8 1 Spt20 family HTH_Tnp_Tc3_1 PF11427.8 CDI79751.1 - 0.02 14.7 1.7 0.038 13.8 1.7 1.4 1 0 0 1 1 1 0 Tc3 transposase HTH_29 PF13551.6 CDI79751.1 - 0.028 14.5 0.3 0.07 13.2 0.3 1.7 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.6 CDI79751.1 - 1.7 8.9 6.0 0.26 11.4 1.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain SR-25 PF10500.9 CDI79753.1 - 0.00037 20.2 25.7 0.00037 20.2 25.7 2.9 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein JUPITER PF17054.5 CDI79753.1 - 0.063 12.7 10.3 0.032 13.7 8.5 1.4 1 1 0 1 1 1 0 Microtubule-Associated protein Jupiter SOBP PF15279.6 CDI79753.1 - 4.1 7.9 40.2 6.4 7.3 40.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein SNARE_assoc PF09335.11 CDI79755.1 - 1.3e-13 51.5 3.1 1.4e-12 48.2 2.4 2.2 1 1 0 1 1 1 1 SNARE associated Golgi protein DUF726 PF05277.12 CDI79755.1 - 0.39 9.6 2.8 0.55 9.1 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Nucleoporin_FG PF13634.6 CDI79757.1 - 2.9e-37 127.4 303.7 8e-10 39.4 41.6 10.2 2 2 8 10 10 10 9 Nucleoporin FG repeat region Spt20 PF12090.8 CDI79757.1 - 0.079 12.6 5.2 0.16 11.5 5.2 1.4 1 0 0 1 1 1 0 Spt20 family Nitro_FeMo-Co PF02579.17 CDI79757.1 - 0.14 12.5 0.3 0.31 11.4 0.3 1.5 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor DNA_topoisoIV PF00521.20 CDI79759.1 - 1.9e-124 415.9 0.0 2.5e-124 415.4 0.0 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CDI79759.1 - 2.2e-44 150.8 0.6 5.6e-24 84.9 0.2 3.3 2 0 0 2 2 2 2 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CDI79759.1 - 5.3e-20 71.6 0.5 1.1e-19 70.5 0.5 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CDI79759.1 - 6.1e-11 42.8 0.0 2.4e-10 40.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDI79759.1 - 2.8e-07 30.7 0.0 7.2e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Toprim domain FIT1_2 PF17357.2 CDI79759.1 - 0.36 10.9 4.2 7.9 6.6 0.1 2.8 2 0 0 2 2 2 0 Facilitor Of iron transport 1 and 2 Ribosomal_S27 PF01599.19 CDI79760.1 - 7.5e-26 90.0 1.9 1.4e-25 89.2 1.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S27a ubiquitin PF00240.23 CDI79760.1 - 8e-14 51.2 0.0 1.5e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDI79760.1 - 8.4e-07 28.7 0.0 2.3e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CDI79760.1 - 0.0056 16.7 0.1 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_2 PF14560.6 CDI79760.1 - 0.01 16.3 0.0 0.14 12.6 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain IBR PF01485.21 CDI79760.1 - 0.046 14.0 1.2 0.075 13.3 1.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Wound_ind PF08186.11 CDI79760.1 - 0.31 11.5 2.2 0.59 10.6 2.2 1.4 1 0 0 1 1 1 0 Wound-inducible basic protein family EF_TS PF00889.19 CDI79761.1 - 1.4e-29 103.2 0.1 3.3e-29 102.0 0.1 1.5 1 1 0 1 1 1 1 Elongation factor TS TAP_C PF03943.13 CDI79761.1 - 0.0032 17.1 0.0 0.0077 15.9 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain SMAP PF15477.6 CDI79761.1 - 0.024 15.6 0.0 0.12 13.3 0.0 2.2 1 0 0 1 1 1 0 Small acidic protein family Peptidase_M66 PF10462.9 CDI79761.1 - 0.16 10.9 0.0 1.6 7.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase M66 Pkinase PF00069.25 CDI79763.1 - 3e-44 151.4 0.4 4.6e-35 121.3 0.0 4.3 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79763.1 - 1.2e-19 70.6 0.3 7.5e-17 61.5 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 CDI79763.1 - 0.0011 18.4 0.4 0.0011 18.4 0.4 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CDI79763.1 - 0.0052 16.4 1.1 0.12 11.9 0.0 2.8 2 1 1 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 RskA PF10099.9 CDI79763.1 - 0.012 16.0 7.9 0.012 16.0 7.9 5.8 4 2 2 6 6 6 0 Anti-sigma-K factor rskA Haspin_kinase PF12330.8 CDI79763.1 - 0.033 13.1 0.0 0.033 13.1 0.0 2.3 3 1 0 3 3 3 0 Haspin like kinase domain APH PF01636.23 CDI79763.1 - 0.064 13.2 0.2 0.025 14.5 1.1 4.4 4 2 1 5 5 5 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDI79763.1 - 0.15 10.8 0.0 0.15 10.8 0.0 3.6 3 1 0 3 3 3 0 Fungal protein kinase Sec23_trunk PF04811.15 CDI79764.1 - 3.2e-54 184.1 0.0 2.1e-50 171.6 0.0 2.2 2 0 0 2 2 2 2 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDI79764.1 - 3.7e-16 59.6 0.0 6.5e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CDI79764.1 - 4.9e-15 55.3 4.5 8.8e-15 54.5 4.5 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 CDI79764.1 - 4.3e-10 39.3 0.0 9.5e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 CDI79764.1 - 0.0002 21.2 0.0 0.0002 21.2 0.0 2.8 3 0 0 3 3 3 1 Gelsolin repeat Vps36-NZF-N PF16988.5 CDI79764.1 - 0.044 13.2 0.6 0.093 12.1 0.6 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Prp18 PF02840.15 CDI79766.1 - 1.2e-59 200.4 0.6 1.2e-59 200.4 0.6 3.0 3 1 1 4 4 4 1 Prp18 domain PRP4 PF08799.11 CDI79766.1 - 1.3e-12 47.0 0.7 4e-12 45.5 0.7 1.9 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like NOP5NT PF08156.13 CDI79766.1 - 0.41 11.1 2.7 2.3 8.7 0.7 2.7 2 0 0 2 2 2 0 NOP5NT (NUC127) domain RRM_1 PF00076.22 CDI79767.1 - 1.5e-12 47.1 0.0 2.5e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 CDI79767.1 - 1.6e-08 34.9 0.1 1.6e-08 34.9 0.1 2.3 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 GREB1 PF15782.5 CDI79767.1 - 0.73 6.9 6.4 0.98 6.5 6.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SRP-alpha_N PF04086.13 CDI79767.1 - 2.8 7.8 9.9 0.088 12.7 1.3 2.3 3 0 0 3 3 3 0 Signal recognition particle, alpha subunit, N-terminal Spt20 PF12090.8 CDI79767.1 - 4.3 6.9 23.2 1.7 8.2 6.3 2.5 3 0 0 3 3 3 0 Spt20 family Borrelia_P83 PF05262.11 CDI79767.1 - 7.9 4.8 7.9 11 4.3 7.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein VCX_VCY PF15231.6 CDI79769.1 - 0.012 16.3 2.2 0.048 14.3 2.2 1.9 1 1 0 1 1 1 0 Variable charge X/Y family Peptidase_M60_C PF18630.1 CDI79769.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase M60 C-terminal domain AP2 PF00847.20 CDI79770.1 - 0.00056 20.1 5.2 0.00056 20.1 5.2 4.5 4 1 0 4 4 4 1 AP2 domain UPRTase PF14681.6 CDI79771.1 - 3.5e-67 225.9 0.0 5.4e-67 225.2 0.0 1.2 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CDI79771.1 - 2.9e-07 30.1 0.1 7e-07 28.9 0.1 1.5 1 1 1 2 2 2 1 Phosphoribosyl transferase domain Macoilin PF09726.9 CDI79772.1 - 0.045 12.3 1.5 0.069 11.7 1.5 1.4 1 0 0 1 1 1 0 Macoilin family Cadherin_C PF01049.17 CDI79772.1 - 0.072 13.4 1.8 0.11 12.9 1.8 1.2 1 0 0 1 1 1 0 Cadherin cytoplasmic region Miga PF10265.9 CDI79772.1 - 1.8 7.4 5.1 2.5 7.0 5.1 1.1 1 0 0 1 1 1 0 Mitoguardin SR-25 PF10500.9 CDI79772.1 - 2.5 7.7 17.0 3.5 7.2 17.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 CDI79772.1 - 2.8 8.6 11.5 4.2 8.0 11.5 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain NAM-associated PF14303.6 CDI79774.1 - 0.3 11.8 0.0 0.3 11.8 0.0 11.1 3 2 5 8 8 8 0 No apical meristem-associated C-terminal domain DUF1298 PF06974.13 CDI79775.1 - 5.1e-09 36.2 0.0 1.1e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 CDI79775.1 - 0.00026 20.9 1.7 0.0008 19.3 0.0 2.5 2 1 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain zf-ribbon_3 PF13248.6 CDI79775.1 - 0.065 12.7 1.0 0.2 11.1 1.0 1.9 1 0 0 1 1 1 0 zinc-ribbon domain SNF PF00209.18 CDI79777.1 - 1.3e-20 73.6 38.4 1.4e-20 73.5 32.0 2.2 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family VIT1 PF01988.19 CDI79778.1 - 1.1e-46 159.4 1.4 3.9e-36 124.9 0.0 2.1 1 1 1 2 2 2 2 VIT family EF-hand_7 PF13499.6 CDI79779.1 - 1.5e-15 57.4 0.0 7.3e-08 32.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI79779.1 - 2.8e-15 54.6 0.0 0.0017 17.8 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDI79779.1 - 1.3e-12 46.5 0.0 0.012 15.5 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDI79779.1 - 5.2e-08 32.0 0.1 0.39 10.3 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 CDI79779.1 - 2.4e-07 31.0 0.0 0.0047 17.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CDI79779.1 - 2.4e-07 30.5 0.0 0.37 10.7 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDI79779.1 - 0.092 13.1 0.0 7.2 7.0 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pullulanase_N2 PF17967.1 CDI79782.1 - 0.12 13.2 0.2 0.26 12.1 0.2 1.5 1 0 0 1 1 1 0 Pullulanase N2 domain FHA PF00498.26 CDI79783.1 - 5.7e-05 23.4 0.0 0.00039 20.7 0.0 2.1 1 1 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDI79783.1 - 0.034 14.4 0.0 0.058 13.7 0.0 1.3 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Cas_CXXC_CXXC PF09706.10 CDI79784.1 - 0.05 13.9 0.9 0.05 13.9 0.9 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) Glutaredoxin PF00462.24 CDI79785.1 - 0.11 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin XRN_N PF03159.18 CDI79786.1 - 3.2e-82 275.6 0.0 4.8e-82 275.0 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDI79786.1 - 1.8e-52 178.8 9.9 1.2e-23 83.8 0.0 3.4 2 1 0 3 3 3 3 Xrn1 helical domain Tape_meas_lam_C PF09718.10 CDI79787.1 - 0.021 14.9 0.2 0.83 9.8 0.0 2.5 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF1539 PF07560.11 CDI79787.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) RRF PF01765.19 CDI79787.1 - 0.4 10.6 5.9 1.2 9.1 5.9 1.8 1 0 0 1 1 1 0 Ribosome recycling factor YtxH PF12732.7 CDI79787.1 - 2.3 8.8 12.5 0.35 11.4 6.5 2.7 2 1 1 3 3 3 0 YtxH-like protein DUF883 PF05957.13 CDI79787.1 - 2.3 8.9 15.7 0.96 10.1 0.9 3.8 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF2477 PF10631.9 CDI79787.1 - 5.3 7.7 6.4 0.47 11.1 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) Caldesmon PF02029.15 CDI79788.1 - 0.00036 19.5 25.0 0.00036 19.5 25.0 4.7 6 0 0 6 6 6 2 Caldesmon DNA_pol_phi PF04931.13 CDI79788.1 - 0.018 13.2 0.1 0.018 13.2 0.1 5.3 4 1 1 5 5 5 0 DNA polymerase phi Abhydrolase_9_N PF15420.6 CDI79788.1 - 0.024 14.6 0.2 0.024 14.6 0.2 3.3 3 0 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus Nuc_deoxyrib_tr PF05014.15 CDI79788.1 - 0.13 12.3 5.3 0.053 13.5 1.0 2.8 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase AAA_23 PF13476.6 CDI79788.1 - 2.1 8.8 0.0 2.1 8.8 0.0 6.4 5 2 0 5 5 5 0 AAA domain DUF913 PF06025.12 CDI79788.1 - 7.5 5.4 38.2 0.15 11.0 1.6 4.7 4 0 0 4 4 4 0 Domain of Unknown Function (DUF913) Corona_nucleoca PF00937.18 CDI79790.1 - 0.0092 15.1 2.2 0.012 14.6 2.2 1.2 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein ABC_tran PF00005.27 CDI79791.1 - 5.3e-21 75.6 2.2 5.3e-21 75.6 2.2 5.2 3 2 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 CDI79791.1 - 2.3e-08 34.2 0.0 9.7e-06 25.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDI79791.1 - 0.0043 17.0 0.4 0.0043 17.0 0.4 3.4 3 1 0 4 4 4 1 RsgA GTPase AAA_29 PF13555.6 CDI79791.1 - 0.0094 15.7 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDI79791.1 - 0.1 13.1 0.2 0.1 13.1 0.2 6.2 4 2 1 5 5 5 0 AAA domain MMR_HSR1 PF01926.23 CDI79791.1 - 0.55 10.3 2.9 1 9.4 0.0 2.9 3 0 0 3 3 3 0 50S ribosome-binding GTPase EMC1_C PF07774.13 CDI79792.1 - 1.4e-22 80.4 0.0 3.4e-22 79.2 0.0 1.7 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CDI79792.1 - 7.3e-09 35.6 18.6 2.4e-05 24.0 9.6 3.8 3 1 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 CDI79792.1 - 2.9e-07 30.1 0.2 1.3 9.1 0.1 4.4 4 0 0 4 4 4 2 PQQ enzyme repeat SPRY PF00622.28 CDI79792.1 - 0.65 10.1 2.5 1.9 8.6 2.5 1.7 1 0 0 1 1 1 0 SPRY domain FliO PF04347.13 CDI79792.1 - 2.2 8.7 10.4 0.66 10.3 0.9 4.0 3 1 0 3 3 3 0 Flagellar biosynthesis protein, FliO DUF1772 PF08592.11 CDI79793.1 - 0.0073 16.6 1.7 0.0073 16.6 1.7 7.6 5 3 2 7 7 7 1 Domain of unknown function (DUF1772) RNA_pol_Rpc4 PF05132.14 CDI79793.1 - 0.01 16.3 3.1 0.01 16.3 3.1 10.2 7 3 2 9 9 9 0 RNA polymerase III RPC4 Peptidase_M56 PF05569.11 CDI79793.1 - 0.13 11.5 11.0 0.2 10.8 2.9 4.0 3 0 0 3 3 3 0 BlaR1 peptidase M56 Tetraspanin PF00335.20 CDI79793.1 - 0.65 9.7 8.7 0.028 14.1 0.5 2.8 3 0 0 3 3 3 0 Tetraspanin family Porin_3 PF01459.22 CDI79794.1 - 2.2e-16 60.1 0.0 2.6e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Pkinase PF00069.25 CDI79795.1 - 9.4e-13 48.1 3.8 3.3e-07 29.9 0.5 3.3 3 1 0 3 3 3 2 Protein kinase domain AF-4 PF05110.13 CDI79795.1 - 0.00016 20.0 6.9 0.00016 20.0 6.9 7.0 5 1 1 7 7 7 1 AF-4 proto-oncoprotein Pkinase_Tyr PF07714.17 CDI79795.1 - 0.0043 16.4 0.2 2.6 7.3 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase DUF3843 PF12954.7 CDI79795.1 - 0.35 9.8 5.2 0.59 9.0 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3843) SPX PF03105.19 CDI79795.1 - 0.51 10.2 0.0 0.51 10.2 0.0 5.1 2 2 1 3 3 3 0 SPX domain RskA PF10099.9 CDI79795.1 - 0.75 10.1 0.0 0.75 10.1 0.0 9.7 5 4 1 7 7 7 0 Anti-sigma-K factor rskA DUF742 PF05331.11 CDI79796.1 - 0.15 11.9 6.5 0.09 12.6 0.6 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF742) DUF4148 PF13663.6 CDI79797.1 - 0.019 15.2 9.2 0.73 10.1 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) K_channel_TID PF07941.11 CDI79797.1 - 0.36 11.3 13.6 2.6 8.6 3.7 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain HdeA PF06411.11 CDI79797.1 - 1.5 9.0 8.2 2.6 8.3 1.3 2.2 2 0 0 2 2 2 0 HdeA/HdeB family Spt5-NGN PF03439.13 CDI79798.1 - 1.6e-06 27.9 0.0 5.9e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 CDI79798.1 - 0.089 12.8 0.5 1.2e+02 2.8 0.0 4.0 4 0 0 4 4 4 0 KOW motif SUIM_assoc PF16619.5 CDI79798.1 - 2.7 8.1 25.5 0.3 11.2 3.9 3.1 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI79800.1 - 6.7e-05 23.1 44.7 0.00041 20.5 21.7 2.7 3 0 0 3 3 2 2 Transcription factor IIA, alpha/beta subunit Spore_YhcN_YlaJ PF09580.10 CDI79800.1 - 0.00096 19.3 0.2 0.0021 18.1 0.2 1.5 1 1 0 1 1 1 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RskA PF10099.9 CDI79800.1 - 0.0042 17.4 0.4 0.0042 17.4 0.4 7.7 3 2 2 6 6 4 1 Anti-sigma-K factor rskA Peptidase_S49_N PF08496.10 CDI79800.1 - 0.055 13.5 6.2 1 9.4 1.6 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal MecA PF05389.12 CDI79800.1 - 0.056 13.1 5.1 0.22 11.2 0.6 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Rxt3 PF08642.10 CDI79800.1 - 0.11 13.3 5.5 0.28 12.0 1.5 2.5 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF2828 PF11443.8 CDI79800.1 - 0.12 10.5 5.8 0.2 9.7 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) eIF-3_zeta PF05091.12 CDI79800.1 - 0.16 11.0 16.1 0.37 9.7 7.8 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Connexin PF00029.19 CDI79800.1 - 0.17 11.6 6.7 0.13 12.0 1.5 2.3 2 0 0 2 2 2 0 Connexin Lin-8 PF03353.15 CDI79800.1 - 0.45 10.0 22.1 0.12 11.9 12.6 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Reprolysin_3 PF13582.6 CDI79800.1 - 0.75 10.3 6.7 1.3 9.5 0.1 2.5 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Methyltransf_12 PF08242.12 CDI79800.1 - 1.1 10.0 2.8 3.9 8.3 0.1 2.5 2 0 0 2 2 2 0 Methyltransferase domain Apt1 PF10351.9 CDI79800.1 - 1.3 7.8 18.2 0.06 12.2 10.9 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain SpoIIP PF07454.11 CDI79800.1 - 2.2 7.7 14.0 0.69 9.3 5.4 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Vfa1 PF08432.10 CDI79800.1 - 2.5 8.4 15.6 3.5 7.9 9.1 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 G0-G1_switch_2 PF15103.6 CDI79800.1 - 2.5 8.6 8.3 11 6.4 3.4 2.9 2 0 0 2 2 2 0 G0/G1 switch protein 2 Presenilin PF01080.17 CDI79800.1 - 3.6 6.3 22.3 0.31 9.7 11.5 2.3 2 0 0 2 2 2 0 Presenilin SOBP PF15279.6 CDI79800.1 - 3.9 8.0 13.8 3.6 8.1 9.2 2.5 2 0 0 2 2 2 0 Sine oculis-binding protein Orf78 PF06024.12 CDI79800.1 - 4.4 7.7 10.1 40 4.6 0.1 2.7 2 1 0 2 2 2 0 Orf78 (ac78) OATP PF03137.20 CDI79800.1 - 4.9 5.3 6.6 2.3 6.4 2.7 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4199 PF13858.6 CDI79800.1 - 6.6 7.1 7.2 6.6 7.1 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) U1snRNP70_N PF12220.8 CDI79800.1 - 7.3 7.3 12.4 0.86 10.3 2.3 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RED_N PF07808.13 CDI79800.1 - 7.9 6.0 23.9 5.2 6.6 13.3 2.5 2 1 0 2 2 2 0 RED-like protein N-terminal region Macoilin PF09726.9 CDI79800.1 - 8.4 4.8 28.9 0.66 8.5 13.6 2.3 2 0 0 2 2 2 0 Macoilin family AAA_23 PF13476.6 CDI79800.1 - 8.5 6.8 21.4 2.5 8.5 7.6 2.4 2 0 0 2 2 2 0 AAA domain RR_TM4-6 PF06459.12 CDI79800.1 - 8.6 6.1 13.7 1.6 8.5 4.7 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PRP3 PF08572.10 CDI79800.1 - 9.1 5.9 18.8 1.2 8.8 7.2 2.4 2 0 0 2 2 2 0 pre-mRNA processing factor 3 (PRP3) SOG2 PF10428.9 CDI79802.1 - 0.0022 17.3 9.8 0.0022 17.3 9.8 4.0 2 1 1 4 4 4 1 RAM signalling pathway protein TFIIA PF03153.13 CDI79802.1 - 0.0063 16.6 20.2 0.0063 16.6 20.2 3.3 2 1 1 3 3 3 2 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI79802.1 - 0.0072 16.0 24.3 0.0072 16.0 24.3 4.5 3 1 0 3 3 3 2 Spt20 family LysM PF01476.20 CDI79803.1 - 1.8e-08 34.3 0.0 3.4e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 LysM domain RskA PF10099.9 CDI79803.1 - 3.4 7.9 32.4 0.54 10.5 7.7 3.4 3 0 0 3 3 3 0 Anti-sigma-K factor rskA Pex14_N PF04695.13 CDI79805.1 - 0.00011 22.8 1.5 0.00019 22.1 1.5 1.4 1 1 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Apt1 PF10351.9 CDI79805.1 - 0.03 13.2 2.6 0.027 13.3 2.6 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI79805.1 - 0.03 12.9 5.2 0.03 12.9 5.2 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI79805.1 - 0.14 10.9 1.0 0.15 10.8 1.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4614 PF15391.6 CDI79805.1 - 7.6 6.5 11.6 11 6.0 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) RskA PF10099.9 CDI79806.1 - 0.023 15.0 0.0 0.023 15.0 0.0 19.7 6 4 10 17 17 17 0 Anti-sigma-K factor rskA DUF853 PF05872.12 CDI79807.1 - 9.8 4.6 12.2 12 4.4 12.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Proteasome PF00227.26 CDI79809.1 - 5.9e-20 71.6 0.0 7.1e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF637 PF04830.13 CDI79809.1 - 0.014 15.2 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Possible hemagglutinin (DUF637) FBPase PF00316.20 CDI79810.1 - 3.8e-67 225.4 0.0 5.1e-67 225.0 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Beach PF02138.18 CDI79812.1 - 3.4e-76 256.3 0.0 7.4e-45 153.5 0.0 2.4 2 0 0 2 2 2 2 Beige/BEACH domain WD40 PF00400.32 CDI79812.1 - 0.076 13.9 3.8 0.13 13.2 0.0 3.4 4 0 0 4 4 4 0 WD domain, G-beta repeat TFIIA PF03153.13 CDI79813.1 - 0.0012 18.9 42.8 0.027 14.5 6.4 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI79813.1 - 0.011 15.3 2.8 0.011 15.3 2.8 4.2 3 1 1 4 4 4 0 Spt20 family Ribosomal_60s PF00428.19 CDI79813.1 - 0.81 10.3 40.5 0.96 10.1 9.8 4.7 4 0 0 4 4 4 0 60s Acidic ribosomal protein RskA PF10099.9 CDI79813.1 - 2.3 8.5 59.6 0.96 9.7 27.2 3.8 1 1 1 3 3 3 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI79814.1 - 1.7 8.6 20.6 2 8.3 20.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2339 PF10101.9 CDI79814.1 - 9.2 4.7 24.3 12 4.3 24.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Trp_oprn_chp PF09534.10 CDI79815.1 - 5.9e-05 22.9 31.5 8.2e-05 22.5 31.5 1.2 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Miga PF10265.9 CDI79815.1 - 1.1 8.2 4.7 1.4 7.8 4.7 1.2 1 0 0 1 1 1 0 Mitoguardin Hamartin PF04388.12 CDI79815.1 - 1.3 7.6 8.9 1.5 7.3 8.9 1.1 1 0 0 1 1 1 0 Hamartin protein Methyltransf_16 PF10294.9 CDI79816.1 - 6.4e-08 32.5 0.2 0.013 15.2 0.0 2.8 2 1 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 CDI79816.1 - 2.9e-05 23.9 0.4 2.9e-05 23.9 0.4 2.7 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDI79816.1 - 0.0027 17.3 0.1 0.0086 15.6 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CDI79816.1 - 0.0057 16.1 1.2 0.014 14.8 0.0 2.1 1 1 1 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDI79816.1 - 0.068 13.9 1.5 1.1 10.0 0.2 3.1 2 1 1 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDI79816.1 - 2.5 8.9 8.3 46 4.8 2.9 3.8 3 1 0 3 3 3 0 Methyltransferase domain Spt20 PF12090.8 CDI79817.1 - 1.1e-05 25.2 7.7 1.1e-05 25.2 7.7 9.9 5 3 3 9 9 9 2 Spt20 family RskA PF10099.9 CDI79817.1 - 0.0011 19.4 14.8 0.0011 19.4 14.8 17.3 8 5 3 11 11 11 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI79818.1 - 0.01 15.5 14.7 0.01 15.5 14.7 3.4 3 1 0 3 3 3 0 Spt20 family YflT PF11181.8 CDI79818.1 - 0.063 13.8 3.5 0.21 12.1 3.5 1.9 1 0 0 1 1 1 0 Heat induced stress protein YflT URO-D PF01208.17 CDI79819.1 - 4.7e-80 269.3 0.1 6.2e-74 249.2 0.0 2.3 1 1 1 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) DUF4614 PF15391.6 CDI79819.1 - 0.13 12.2 6.9 0.22 11.5 6.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.9 CDI79819.1 - 0.73 8.3 11.5 0.87 8.1 11.5 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 CDI79819.1 - 5.5 5.1 17.7 7 4.8 17.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.9 CDI79819.1 - 7.3 5.3 9.3 9.7 4.9 9.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SMYLE_N PF18615.1 CDI79819.1 - 7.4 6.0 11.0 10 5.6 11.0 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PARG_cat PF05028.14 CDI79820.1 - 3.1e-42 145.1 0.0 1.8e-18 66.9 0.1 3.8 3 1 0 3 3 3 3 Poly (ADP-ribose) glycohydrolase (PARG) Ribosomal_L14 PF00238.19 CDI79820.1 - 2.4e-10 40.6 0.0 4.2e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e HemY_N PF07219.13 CDI79822.1 - 0.17 12.1 0.8 0.46 10.7 0.8 1.8 1 0 0 1 1 1 0 HemY protein N-terminus MCM_OB PF17207.3 CDI79823.1 - 1.2e-26 93.0 0.1 2e-26 92.3 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 CDI79823.1 - 0.2 12.3 0.0 0.68 10.5 0.0 1.8 1 1 0 1 1 1 0 MCM N-terminal domain MCM PF00493.23 CDI79826.1 - 1.2e-53 181.5 0.4 1.1e-30 106.4 0.1 2.9 1 1 1 2 2 2 2 MCM P-loop domain MCM_lid PF17855.1 CDI79826.1 - 8.6e-29 99.8 18.8 1.1e-20 73.8 2.4 3.4 3 0 0 3 3 3 2 MCM AAA-lid domain MCM_OB PF17207.3 CDI79826.1 - 3e-27 95.0 0.4 3e-27 95.0 0.4 3.3 3 1 1 4 4 4 1 MCM OB domain Dabb PF07876.12 CDI79826.1 - 0.014 16.0 0.1 11 6.7 0.0 3.8 3 0 0 3 3 3 0 Stress responsive A/B Barrel Domain DASH_Dam1 PF08653.10 CDI79826.1 - 1.1 9.2 8.7 5.2 7.0 1.5 3.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF1980 PF09323.10 CDI79828.1 - 9.2 6.1 5.3 4.9 7.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) SUIM_assoc PF16619.5 CDI79829.1 - 0.082 13.0 0.2 0.082 13.0 0.2 11.1 4 2 2 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 eIF-3_zeta PF05091.12 CDI79830.1 - 0.011 14.8 20.6 0.012 14.7 20.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Apt1 PF10351.9 CDI79830.1 - 0.045 12.6 16.8 0.059 12.2 16.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI79830.1 - 0.1 11.1 22.5 0.13 10.8 22.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 PIG-S PF10510.9 CDI79830.1 - 0.47 9.2 23.0 0.54 9.0 23.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Miff PF05644.11 CDI79830.1 - 0.59 9.7 26.6 0.76 9.4 26.6 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Mitofilin PF09731.9 CDI79830.1 - 0.64 8.8 40.4 0.84 8.4 40.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CDC45 PF02724.14 CDI79830.1 - 1.4 7.1 21.8 1.7 6.8 21.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 CDI79830.1 - 1.7 7.5 24.7 2.7 6.9 24.7 1.3 1 0 0 1 1 1 0 Paf1 Asp-B-Hydro_N PF05279.11 CDI79830.1 - 2.4 8.2 14.6 2.9 7.9 14.6 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PCM1_C PF15717.5 CDI79830.1 - 2.6 6.7 28.3 3.1 6.4 28.3 1.3 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Cellulose_synt PF03552.14 CDI79830.1 - 2.7 6.4 7.3 3 6.2 7.3 1.1 1 0 0 1 1 1 0 Cellulose synthase CRT10 PF08728.10 CDI79830.1 - 3.8 5.6 10.6 4.6 5.3 10.6 1.0 1 0 0 1 1 1 0 CRT10 SOBP PF15279.6 CDI79830.1 - 4 8.0 31.1 5.4 7.5 31.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SRP-alpha_N PF04086.13 CDI79830.1 - 4.6 7.1 31.8 6.2 6.7 31.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal V_ATPase_I PF01496.19 CDI79830.1 - 7.9 4.3 24.9 13 3.5 24.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EMC3_TMCO1 PF01956.16 CDI79830.1 - 8 6.2 14.7 9.8 5.9 14.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PAT1 PF09770.9 CDI79830.1 - 8.1 4.6 49.4 9.7 4.3 49.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3450 PF11932.8 CDI79831.1 - 0.003 16.9 6.8 0.003 16.9 6.8 2.9 1 1 1 3 3 3 1 Protein of unknown function (DUF3450) DUF2935 PF11155.8 CDI79831.1 - 0.0058 17.0 1.1 0.0058 17.0 1.1 2.2 2 1 1 3 3 3 1 Domain of unknown function (DUF2935) Fez1 PF06818.15 CDI79831.1 - 0.04 14.4 25.6 0.1 13.1 25.6 1.6 1 1 0 1 1 1 0 Fez1 GCK PF07802.11 CDI79831.1 - 0.093 13.2 0.2 0.093 13.2 0.2 2.8 2 2 0 2 2 2 0 GCK domain Rogdi_lz PF10259.9 CDI79831.1 - 0.11 11.9 2.9 0.13 11.7 2.3 1.4 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein DUF745 PF05335.13 CDI79831.1 - 0.6 9.8 27.4 0.28 10.9 13.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) LMBR1 PF04791.16 CDI79831.1 - 1.5 7.6 11.2 2.1 7.1 11.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 CDI79831.1 - 1.7 8.7 15.8 0.23 11.5 2.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 CDI79831.1 - 7 5.4 33.7 10 4.9 11.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Kinesin PF00225.23 CDI79832.1 - 8.8e-90 301.0 0.0 1.3e-89 300.4 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDI79832.1 - 1.3e-22 80.3 0.0 3e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF4179 PF13786.6 CDI79833.1 - 0.0069 16.8 0.2 0.062 13.8 0.2 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4179) Sporozoite_P67 PF05642.11 CDI79834.1 - 7.3e-06 24.4 0.5 7.3e-06 24.4 0.5 6.6 7 1 0 7 7 7 2 Sporozoite P67 surface antigen Spt20 PF12090.8 CDI79834.1 - 0.00049 19.8 3.7 0.00049 19.8 3.7 7.6 6 1 0 6 6 6 4 Spt20 family Activator_LAG-3 PF11498.8 CDI79834.1 - 0.0018 17.3 8.6 0.0018 17.3 8.6 8.2 8 1 0 8 8 8 2 Transcriptional activator LAG-3 Sin_N PF04801.13 CDI79834.1 - 0.37 9.9 45.5 0.016 14.4 1.9 5.9 5 1 0 5 5 5 0 Sin-like protein conserved region DUF2967 PF11179.8 CDI79835.1 - 0.0025 16.0 5.8 0.0029 15.8 5.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2967) WD40 PF00400.32 CDI79835.1 - 0.064 14.2 0.4 0.17 12.8 0.1 1.9 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF5470 PF17564.2 CDI79835.1 - 0.42 10.8 4.3 0.83 9.9 4.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5470) CSN8_PSD8_EIF3K PF10075.9 CDI79836.1 - 6.6e-13 48.9 0.8 6.6e-13 48.9 0.8 3.0 4 0 0 4 4 4 1 CSN8/PSMD8/EIF3K family RskA PF10099.9 CDI79836.1 - 8.2e-05 23.0 4.8 8.2e-05 23.0 4.8 3.0 3 1 0 3 3 3 1 Anti-sigma-K factor rskA PCI PF01399.27 CDI79836.1 - 0.023 15.2 0.5 0.023 15.2 0.5 2.6 3 0 0 3 3 3 0 PCI domain SUIM_assoc PF16619.5 CDI79836.1 - 0.51 10.4 41.4 0.03 14.4 4.3 5.7 5 1 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 CDI79837.1 - 1.7e-44 152.1 0.0 2.4e-16 59.9 0.0 3.9 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79837.1 - 1.6e-21 76.8 2.4 3.5e-13 49.4 4.1 3.3 2 1 0 2 2 2 2 Protein tyrosine kinase TTD PF12148.8 CDI79837.1 - 0.48 10.3 2.8 1.5 8.7 2.8 1.8 1 0 0 1 1 1 0 Tandem tudor domain within UHRF1 Dehydrin PF00257.19 CDI79838.1 - 0.0091 16.6 5.3 0.0091 16.6 5.3 7.1 7 1 0 7 7 7 1 Dehydrin MID_MedPIWI PF18296.1 CDI79838.1 - 0.0095 15.8 3.4 0.0095 15.8 3.4 3.8 4 1 0 4 4 4 1 MID domain of medPIWI EphA2_TM PF14575.6 CDI79838.1 - 0.15 12.9 1.4 10 7.1 0.1 3.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain NAD_Gly3P_dh_C PF07479.14 CDI79838.1 - 0.15 12.3 4.9 0.28 11.5 3.6 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus DUF4834 PF16118.5 CDI79838.1 - 2 9.4 5.5 8.7 7.4 0.6 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Suf PF05843.14 CDI79838.1 - 2.7 7.9 6.3 7.2 6.5 0.6 2.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CDI79839.1 - 0.42 10.2 10.3 0.42 10.2 10.3 1.1 1 0 0 1 1 1 0 Spt20 family Activator_LAG-3 PF11498.8 CDI79839.1 - 2.8 6.8 17.0 3.2 6.6 17.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HTH_23 PF13384.6 CDI79840.1 - 0.0017 18.1 0.3 0.016 15.0 0.1 2.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CDI79840.1 - 0.011 15.9 0.2 0.011 15.9 0.2 5.6 4 1 0 4 4 4 0 Helix-turn-helix domain Cnd1 PF12717.7 CDI79842.1 - 7.3e-06 26.1 2.0 0.98 9.4 0.1 6.3 6 0 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 CAF1 PF04857.20 CDI79842.1 - 0.0011 18.2 1.4 0.0011 18.2 1.4 5.4 3 2 1 4 4 4 1 CAF1 family ribonuclease BUD22 PF09073.10 CDI79842.1 - 0.016 14.6 0.0 0.016 14.6 0.0 8.4 8 2 1 9 9 9 0 BUD22 MMgT PF10270.9 CDI79842.1 - 1 9.8 6.9 18 5.8 0.1 4.1 3 0 0 3 3 3 0 Membrane magnesium transporter Cohesin_HEAT PF12765.7 CDI79842.1 - 3.6 8.0 7.2 26 5.2 0.2 3.6 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Rieske PF00355.26 CDI79843.1 - 1.3e-06 28.3 0.8 2.3e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 CDI79843.1 - 8.1e-05 22.5 0.1 0.00021 21.2 0.0 1.7 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain DUF2778 PF10908.8 CDI79843.1 - 0.018 15.3 0.6 0.03 14.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2778) TFIIA PF03153.13 CDI79843.1 - 0.064 13.2 13.8 0.11 12.5 13.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI79843.1 - 1.4 7.6 4.3 2.3 6.9 4.3 1.2 1 0 0 1 1 1 0 Presenilin Chorion_2 PF03964.15 CDI79843.1 - 2 9.3 8.1 7.9 7.4 3.6 2.3 2 0 0 2 2 2 0 Chorion family 2 COX7B PF05392.11 CDI79843.1 - 2.9 7.6 7.7 0.17 11.5 0.4 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB Rpp20 PF12328.8 CDI79843.1 - 4.8 7.1 5.7 5.8 6.9 0.4 2.1 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Myb_DNA-binding PF00249.31 CDI79844.1 - 0.00037 20.6 1.2 0.00085 19.5 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain AF-4 PF05110.13 CDI79844.1 - 0.00056 18.2 12.1 0.00056 18.2 12.1 7.1 6 1 0 6 6 6 2 AF-4 proto-oncoprotein Androgen_recep PF02166.16 CDI79844.1 - 0.0011 17.9 8.3 0.0011 17.9 8.3 17.5 12 3 4 16 16 16 2 Androgen receptor GAF PF01590.26 CDI79845.1 - 1.3e-07 32.4 0.0 3.6e-07 30.9 0.0 1.8 2 0 0 2 2 2 1 GAF domain GAF_2 PF13185.6 CDI79845.1 - 1.7e-05 25.1 0.3 6.3e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 GAF domain DUF755 PF05501.11 CDI79845.1 - 0.0016 18.7 8.1 0.0016 18.7 8.1 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF755) Sporozoite_P67 PF05642.11 CDI79845.1 - 0.0017 16.5 12.5 0.0022 16.2 12.5 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen DUF572 PF04502.13 CDI79845.1 - 0.0019 17.9 3.7 0.0019 17.9 3.7 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF572) Suf PF05843.14 CDI79845.1 - 0.024 14.7 3.2 0.034 14.1 3.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RAM PF15320.6 CDI79845.1 - 1.8 9.2 9.2 17 6.1 0.1 2.8 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein Velvet PF11754.8 CDI79845.1 - 2.5 8.0 12.1 0.088 12.7 5.6 1.7 2 0 0 2 2 2 0 Velvet factor Apt1 PF10351.9 CDI79845.1 - 5.5 5.7 14.6 0.11 11.3 5.9 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain Hid1 PF12722.7 CDI79845.1 - 7.4 4.6 11.0 11 3.9 11.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CDI79845.1 - 8.5 6.4 6.6 2.3 8.2 3.5 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TMEM65 PF10507.9 CDI79846.1 - 1.5e-10 41.0 0.1 1.6e-06 28.0 0.0 3.6 3 1 1 4 4 4 2 Transmembrane protein 65 Utp14 PF04615.13 CDI79846.1 - 0.031 12.9 27.9 0.026 13.1 22.0 2.1 2 0 0 2 2 2 0 Utp14 protein FHIPEP PF00771.20 CDI79846.1 - 1.6 7.1 5.7 3.4 6.0 5.7 1.5 1 0 0 1 1 1 0 FHIPEP family Fra10Ac1 PF09725.9 CDI79848.1 - 5.2e-11 42.7 6.7 1.5e-09 38.0 6.7 2.5 1 1 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 BAR_2 PF10455.9 CDI79848.1 - 3.1 6.9 7.3 6.3 5.8 7.3 1.4 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking DEAD PF00270.29 CDI79849.1 - 5.6e-14 52.3 0.1 1.2e-13 51.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Atg8 PF02991.16 CDI79851.1 - 8.4e-33 112.7 0.1 1.5e-32 111.8 0.1 1.4 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CDI79851.1 - 1.9e-05 25.0 0.1 5.7e-05 23.4 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 EDR1 PF14381.6 CDI79852.1 - 8 6.1 7.1 22 4.7 7.1 1.7 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 SBP_bac_10 PF07596.11 CDI79853.1 - 0.0027 17.7 0.9 0.0027 17.7 0.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1559) TFIIA PF03153.13 CDI79853.1 - 0.0084 16.2 14.0 0.0084 16.2 14.0 5.6 3 2 2 5 5 5 1 Transcription factor IIA, alpha/beta subunit Dala_Dala_lig_N PF01820.21 CDI79853.1 - 0.26 11.8 2.4 84 3.7 0.3 4.1 4 0 0 4 4 4 0 D-ala D-ala ligase N-terminus FoP_duplication PF13865.6 CDI79854.1 - 7.1e-16 58.5 8.2 7.1e-16 58.5 8.2 2.7 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 SUIM_assoc PF16619.5 CDI79854.1 - 0.015 15.3 4.6 0.015 15.3 4.6 4.0 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2344 PF10105.9 CDI79854.1 - 0.096 12.5 0.2 0.096 12.5 0.2 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) TFIIA PF03153.13 CDI79855.1 - 5.3e-06 26.7 12.3 7.2e-06 26.3 12.3 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI79855.1 - 0.00068 19.3 14.4 0.00068 19.3 14.4 1.8 2 0 0 2 2 2 1 Spt20 family DUF2722 PF10846.8 CDI79855.1 - 0.0016 17.5 9.7 0.0027 16.7 9.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDI79855.1 - 0.02 15.9 0.1 0.045 14.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Miff PF05644.11 CDI79855.1 - 0.31 10.6 5.5 1.1 8.8 5.3 1.8 2 0 0 2 2 2 0 Mitochondrial and peroxisomal fission factor Mff IER PF05760.12 CDI79855.1 - 0.7 10.1 18.5 1 9.6 18.5 1.2 1 0 0 1 1 1 0 Immediate early response protein (IER) Ndc1_Nup PF09531.10 CDI79855.1 - 0.83 8.3 10.0 1.2 7.8 10.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NUDE_C PF04880.13 CDI79855.1 - 0.91 10.0 10.2 1.5 9.3 10.2 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region PAT1 PF09770.9 CDI79855.1 - 2.1 6.5 12.6 2.9 6.1 12.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RLL PF10036.9 CDI79855.1 - 4.1 7.2 12.3 6.8 6.5 12.3 1.3 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Mcm10 PF09332.11 CDI79855.1 - 5.4 6.3 10.7 8 5.8 10.7 1.2 1 0 0 1 1 1 0 Mcm10 replication factor SRP-alpha_N PF04086.13 CDI79855.1 - 6.2 6.7 11.2 9.3 6.1 11.2 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Roughex PF06020.11 CDI79855.1 - 8.5 5.4 12.5 14 4.6 12.5 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CDI79855.1 - 8.9 5.0 8.5 13 4.4 8.5 1.2 1 0 0 1 1 1 0 Presenilin LETM1 PF07766.13 CDI79859.1 - 3.5e-82 275.7 4.9 3.5e-82 275.7 4.9 2.3 2 1 0 2 2 2 1 LETM1-like protein PITH PF06201.13 CDI79861.1 - 3.3e-13 50.1 0.0 6.8e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 PITH domain SOG2 PF10428.9 CDI79861.1 - 0.22 10.7 12.2 0.27 10.4 12.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Spore_coat_CotO PF14153.6 CDI79861.1 - 0.58 10.1 8.5 0.8 9.6 8.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Presenilin PF01080.17 CDI79861.1 - 2.2 6.9 6.4 2.7 6.7 6.4 1.1 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 CDI79861.1 - 2.6 7.4 14.8 3.4 7.0 14.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SRP-alpha_N PF04086.13 CDI79861.1 - 3.2 7.6 10.1 4.7 7.0 10.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 CDI79861.1 - 3.4 7.4 5.7 5 6.9 5.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CDI79861.1 - 7.5 6.1 6.9 11 5.6 6.9 1.4 1 0 0 1 1 1 0 Spt20 family GREB1 PF15782.5 CDI79861.1 - 9.3 3.2 7.4 10 3.1 7.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DnaJ PF00226.31 CDI79863.1 - 1e-08 35.2 0.0 2.2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain GTA_TIM PF13547.6 CDI79863.1 - 0.0079 15.5 1.1 0.011 15.0 1.1 1.3 1 0 0 1 1 1 1 GTA TIM-barrel-like domain Laminin_G_3 PF13385.6 CDI79867.1 - 2.1e-18 66.9 0.0 1e-17 64.7 0.0 2.0 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 CDI79867.1 - 0.041 14.5 0.0 0.11 13.1 0.0 1.7 1 0 0 1 1 1 0 Laminin G domain ACDC PF14733.6 CDI79868.1 - 9.7e-25 86.7 0.2 2.4e-24 85.5 0.2 1.7 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 CDI79868.1 - 1.8e-06 28.0 4.9 4.6e-06 26.8 4.9 1.8 1 0 0 1 1 1 1 AP2 domain ATP-sulfurylase PF01747.17 CDI79869.1 - 1.1e-90 302.7 0.0 1.5e-90 302.3 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 CDI79869.1 - 5.6e-40 136.8 0.5 4.6e-38 130.6 0.2 3.0 2 1 0 2 2 2 1 Adenylylsulphate kinase PUA_2 PF14306.6 CDI79869.1 - 1.3e-31 109.4 0.1 9e-31 106.7 0.1 2.0 1 1 0 1 1 1 1 PUA-like domain CIAPIN1 PF05093.13 CDI79870.1 - 1e-20 74.1 15.3 1.8e-17 63.7 3.0 2.2 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GpcrRhopsn4 PF10192.9 CDI79871.1 - 0.0057 16.1 0.2 0.009 15.5 0.2 1.2 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Adenyl_cycl_N PF12633.7 CDI79871.1 - 0.022 14.7 0.1 0.64 9.9 0.0 2.4 2 0 0 2 2 2 0 Adenylate cyclase NT domain Abi_2 PF07751.11 CDI79873.1 - 0.19 12.0 0.2 1.4 9.1 0.0 2.5 3 0 0 3 3 3 0 Abi-like protein DUF4834 PF16118.5 CDI79874.1 - 0.0054 17.7 2.6 0.012 16.5 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Oleosin PF01277.17 CDI79874.1 - 0.067 13.0 0.0 0.26 11.1 0.0 2.1 1 0 0 1 1 1 0 Oleosin DUF1943 PF09172.11 CDI79874.1 - 0.067 12.4 0.7 0.18 11.0 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Mif2_N PF15624.6 CDI79874.1 - 0.23 12.2 5.1 0.13 12.9 1.3 2.6 3 0 0 3 3 3 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal OATP PF03137.20 CDI79874.1 - 0.24 9.6 0.1 0.5 8.6 0.1 1.5 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2951 PF11166.8 CDI79874.1 - 1.7 8.9 4.1 1.6 9.0 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DUF913 PF06025.12 CDI79874.1 - 1.9 7.4 8.7 2 7.3 0.6 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Folate_carrier PF01770.18 CDI79874.1 - 3.6 6.2 6.0 0.27 9.9 0.8 1.7 2 0 0 2 2 2 0 Reduced folate carrier LUC7 PF03194.15 CDI79875.1 - 1.3 8.7 7.3 0.09 12.4 2.1 1.8 2 0 0 2 2 2 0 LUC7 N_terminus EccE PF11203.8 CDI79875.1 - 7.1 7.0 6.5 1.1 9.6 0.9 2.7 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE FliE PF02049.18 CDI79876.1 - 2.9 8.1 11.3 0.2 11.8 1.3 3.6 3 0 0 3 3 3 0 Flagellar hook-basal body complex protein FliE PLU-1 PF08429.11 CDI79878.1 - 8.3e-18 64.6 22.3 9.3e-14 51.3 0.1 8.7 8 3 1 9 9 9 3 PLU-1-like protein Zf_RING PF16744.5 CDI79878.1 - 0.055 13.6 0.1 0.63 10.2 0.0 2.9 2 0 0 2 2 2 0 KIAA1045 RING finger C1_1 PF00130.22 CDI79878.1 - 0.13 12.2 0.3 0.34 10.8 0.3 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 CDI79878.1 - 0.14 12.1 2.0 0.21 11.5 0.2 2.2 2 0 0 2 2 2 0 PHD-finger DUF4644 PF15486.6 CDI79879.1 - 0.24 11.2 0.1 0.24 11.2 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4644) GST_C PF00043.25 CDI79879.1 - 4.5 7.5 5.4 43 4.4 0.0 3.3 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain Hydrolase_4 PF12146.8 CDI79880.1 - 3.6e-19 69.0 12.0 6.5e-07 28.9 0.1 4.9 4 0 0 4 4 4 4 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDI79880.1 - 0.13 11.9 0.0 0.13 11.9 0.0 4.7 5 1 0 5 5 5 0 alpha/beta hydrolase fold EOS1 PF12326.8 CDI79880.1 - 1 9.3 13.1 1.8 8.4 0.1 3.7 3 2 0 3 3 3 0 N-glycosylation protein WD40 PF00400.32 CDI79881.1 - 0.0013 19.5 15.2 0.22 12.5 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI79881.1 - 0.0093 16.2 0.0 0.26 11.6 0.0 2.9 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain BTB PF00651.31 CDI79882.1 - 9.3e-07 29.1 0.3 5.5e-06 26.6 0.3 2.3 1 1 0 1 1 1 1 BTB/POZ domain Med3 PF11593.8 CDI79882.1 - 0.00018 20.8 17.9 0.00018 20.8 17.9 12.9 5 2 6 12 12 12 1 Mediator complex subunit 3 fungal TFIIA PF03153.13 CDI79882.1 - 0.00056 20.0 20.6 0.00056 20.0 20.6 6.1 3 2 2 5 5 5 2 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.22 CDI79884.1 - 3.9e-22 77.8 0.3 2e-16 59.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI79884.1 - 1.1e-07 31.9 0.0 0.002 18.2 0.0 2.4 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 CDI79884.1 - 0.00088 18.9 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AF-4 PF05110.13 CDI79884.1 - 0.14 10.3 4.6 0.14 10.2 4.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PHM7_cyt PF14703.6 CDI79884.1 - 0.17 12.1 5.9 0.32 11.2 0.6 3.0 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter TAF4 PF05236.14 CDI79884.1 - 0.38 10.5 2.9 0.46 10.2 2.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Tic110 PF16940.5 CDI79884.1 - 1.3 7.4 8.1 1.2 7.5 7.2 1.3 1 1 0 1 1 1 0 Chloroplast envelope transporter MSP1_C PF07462.11 CDI79884.1 - 2.5 6.7 4.2 2.6 6.6 4.2 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DnaJ PF00226.31 CDI79885.1 - 7.4e-12 45.2 0.1 1.3e-11 44.5 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain M16C_assoc PF08367.11 CDI79887.1 - 2.1e-50 171.2 0.3 4.2e-50 170.2 0.3 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 CDI79887.1 - 1.5e-23 83.7 0.0 1.1e-19 71.2 0.0 3.6 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDI79887.1 - 0.00026 21.0 0.0 0.0018 18.3 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) FAA_hydro_N_2 PF18288.1 CDI79887.1 - 1.8 9.0 4.8 12 6.5 0.4 3.4 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 DNA_pol_A PF00476.20 CDI79889.1 - 2e-56 191.7 5.1 2.6e-51 174.8 0.0 3.3 3 1 0 3 3 3 2 DNA polymerase family A DUF3492 PF11997.8 CDI79890.1 - 0.11 12.2 1.9 0.39 10.4 1.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) DUF1943 PF09172.11 CDI79890.1 - 0.43 9.8 4.1 0.24 10.6 1.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) Apt1 PF10351.9 CDI79892.1 - 0.00083 18.3 1.2 0.00083 18.3 1.2 2.9 3 0 0 3 3 3 1 Golgi-body localisation protein domain DDHD PF02862.17 CDI79892.1 - 2.6 8.2 17.9 0.71 10.0 3.6 3.2 3 0 0 3 3 3 0 DDHD domain Sporozoite_P67 PF05642.11 CDI79892.1 - 7.6 4.5 10.2 0.32 9.0 4.2 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF2813 PF11398.8 CDI79893.1 - 0.26 10.5 14.6 0.34 10.1 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) SAS4 PF15460.6 CDI79893.1 - 1.1 9.3 11.4 2 8.5 11.4 1.4 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 NifQ PF04891.12 CDI79893.1 - 9.8 6.5 12.9 2.2 8.6 9.2 1.7 2 0 0 2 2 2 0 NifQ RAP PF08373.10 CDI79894.1 - 0.018 15.1 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 RAP domain DUF4692 PF15763.5 CDI79895.1 - 0.2 12.1 7.9 0.074 13.5 5.4 1.4 1 1 1 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) SR-25 PF10500.9 CDI79895.1 - 0.31 10.6 18.5 0.7 9.5 18.5 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein WES_acyltransf PF03007.16 CDI79896.1 - 0.64 9.7 11.5 0.8 9.4 11.5 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Spt20 PF12090.8 CDI79896.1 - 1.9 8.1 11.6 2 7.9 11.6 1.2 1 0 0 1 1 1 0 Spt20 family DUF4667 PF15700.5 CDI79897.1 - 8.4e-05 22.8 18.9 0.00089 19.4 0.0 3.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4667) Mito_carr PF00153.27 CDI79897.1 - 0.0034 17.3 0.5 0.0034 17.3 0.5 4.1 4 1 0 4 4 4 1 Mitochondrial carrier protein Ipi1_N PF12333.8 CDI79897.1 - 0.036 14.6 0.1 0.036 14.6 0.1 3.8 5 0 0 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation Rhomboid PF01694.22 CDI79897.1 - 0.13 12.3 2.0 0.2 11.6 2.0 1.3 1 0 0 1 1 1 0 Rhomboid family Dsh_C PF12316.8 CDI79897.1 - 0.98 9.8 23.8 1 9.7 9.9 3.1 3 0 0 3 3 3 0 Segment polarity protein dishevelled (Dsh) C terminal SR-25 PF10500.9 CDI79898.1 - 0.00039 20.1 4.0 0.00039 20.1 4.0 9.4 5 3 4 9 9 9 1 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI79898.1 - 0.0014 18.6 22.3 0.0014 18.6 22.3 6.4 5 2 0 5 5 5 2 SPX domain NAM-associated PF14303.6 CDI79898.1 - 0.0024 18.6 0.0 0.0024 18.6 0.0 8.7 4 2 4 8 8 8 1 No apical meristem-associated C-terminal domain TMEM164 PF14808.6 CDI79898.1 - 0.009 15.4 0.1 6.4 6.0 0.1 2.9 2 0 0 2 2 2 2 TMEM164 family Fumble PF03630.14 CDI79899.1 - 1.5e-23 83.5 6.6 1.5e-23 83.5 6.6 4.2 2 2 0 2 2 2 1 Fumble PAT1 PF09770.9 CDI79899.1 - 0.41 8.8 92.5 0.11 10.8 17.9 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SOBP PF15279.6 CDI79899.1 - 4.3 7.9 56.3 2.1 8.9 39.2 2.6 2 0 0 2 2 2 0 Sine oculis-binding protein Utp14 PF04615.13 CDI79899.1 - 4.4 5.8 50.0 3.1 6.3 9.3 2.3 2 0 0 2 2 2 0 Utp14 protein Fumble PF03630.14 CDI79900.1 - 8.6e-07 28.4 0.3 8.6e-07 28.4 0.3 2.7 3 0 0 3 3 3 1 Fumble SUIM_assoc PF16619.5 CDI79900.1 - 0.00073 19.6 10.8 0.00073 19.6 10.8 3.2 2 1 0 2 2 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI79900.1 - 0.0098 15.5 40.7 0.12 11.9 12.0 2.2 2 0 0 2 2 2 2 Spt20 family Zip PF02535.22 CDI79900.1 - 0.01 15.1 0.4 0.01 15.1 0.4 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter DDHD PF02862.17 CDI79900.1 - 0.036 14.2 5.6 9.7 6.3 5.8 2.2 2 0 0 2 2 2 0 DDHD domain TFIIA PF03153.13 CDI79900.1 - 0.056 13.4 36.5 0.18 11.8 16.8 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI79900.1 - 0.11 12.4 0.1 4 7.3 0.0 2.1 2 0 0 2 2 2 0 N-glycosylation protein DUF5308 PF17233.2 CDI79900.1 - 0.12 12.6 0.1 0.12 12.6 0.1 2.5 2 1 0 2 2 1 0 Family of unknown function (DUF5308) RskA PF10099.9 CDI79900.1 - 0.23 11.7 25.8 14 5.9 0.0 2.9 2 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI79900.1 - 0.42 11.6 0.1 0.42 11.6 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) TCP PF03634.13 CDI79900.1 - 2.1 8.9 18.6 0.68 10.5 1.3 2.1 2 0 0 2 2 2 0 TCP family transcription factor Neur_chan_memb PF02932.16 CDI79900.1 - 2.2 8.3 10.8 3.1 7.8 0.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 CDI79900.1 - 2.8 7.8 14.8 0.93 9.4 0.2 2.1 2 0 0 2 2 2 0 Velvet factor HA2 PF04408.23 CDI79900.1 - 3.7 7.9 9.8 23 5.3 5.6 2.2 2 0 0 2 2 2 0 Helicase associated domain (HA2) Sin_N PF04801.13 CDI79900.1 - 4 6.6 23.1 0.51 9.5 2.6 2.1 2 0 0 2 2 2 0 Sin-like protein conserved region Ctr PF04145.15 CDI79900.1 - 4.6 7.9 5.0 33 5.1 0.0 2.3 2 0 0 2 2 2 0 Ctr copper transporter family VIR_N PF15912.5 CDI79900.1 - 5 6.7 16.6 0.16 11.6 7.7 2.0 2 0 0 2 2 2 0 Virilizer, N-terminal Rxt3 PF08642.10 CDI79900.1 - 9.9 7.0 9.1 28 5.5 0.1 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 XTBD PF11952.8 CDI79901.1 - 4.2e-07 29.6 0.3 6.9e-07 28.9 0.3 1.4 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD DUF3040 PF11239.8 CDI79901.1 - 8.1 6.8 6.0 1.7 8.9 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) IQ PF00612.27 CDI79904.1 - 0.00098 18.7 1.2 0.002 17.7 0.3 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif RNA_pol_Rbc25 PF08292.12 CDI79904.1 - 0.04 14.2 0.9 0.33 11.2 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 NuA4 PF09340.10 CDI79908.1 - 1.2e-18 66.8 0.0 2.3e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 TFIIA PF03153.13 CDI79910.1 - 0.0038 17.3 24.1 0.0038 17.3 24.1 5.8 4 3 0 4 4 4 1 Transcription factor IIA, alpha/beta subunit TPR_1 PF00515.28 CDI79910.1 - 0.062 13.1 9.0 0.35 10.8 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1115 PF06544.12 CDI79911.1 - 9.4e-23 80.9 0.0 9.4e-23 80.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) TPPK_C PF12555.8 CDI79914.1 - 0.25 11.4 4.8 0.35 11.0 4.8 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal Glyco_hydro_9 PF00759.19 CDI79914.1 - 0.27 10.6 2.7 0.27 10.6 2.7 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 Presenilin PF01080.17 CDI79915.1 - 0.012 14.4 0.1 0.012 14.4 0.1 4.5 2 2 2 4 4 4 0 Presenilin Glycos_transf_1 PF00534.20 CDI79915.1 - 0.041 13.4 1.5 0.082 12.4 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferases group 1 RskA PF10099.9 CDI79915.1 - 1.1 9.6 0.0 1.1 9.6 0.0 14.2 4 2 7 12 12 12 0 Anti-sigma-K factor rskA DUF4781 PF16013.5 CDI79916.1 - 0.06 12.2 0.2 0.06 12.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) DUF2207 PF09972.9 CDI79916.1 - 0.5 9.1 1.9 1.4 7.5 0.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) UPF0542 PF15086.6 CDI79916.1 - 1.5 8.8 10.1 0.057 13.4 1.8 3.0 3 1 0 3 3 3 0 Uncharacterised protein family UPF0542 MgtE_N PF03448.17 CDI79917.1 - 0.03 14.9 0.2 0.093 13.3 0.2 1.8 1 0 0 1 1 1 0 MgtE intracellular N domain UPF0565 PF10561.9 CDI79920.1 - 8.4 5.5 8.8 2.9 7.0 3.9 3.0 2 1 0 2 2 2 0 Uncharacterised protein family UPF0565 MIF4G PF02854.19 CDI79921.1 - 8.2e-25 87.7 1.1 1.1e-24 87.3 1.1 1.2 1 0 0 1 1 1 1 MIF4G domain Secretin_N_2 PF07655.13 CDI79921.1 - 0.63 10.6 14.2 6.7 7.3 5.8 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain Ndc1_Nup PF09531.10 CDI79921.1 - 0.68 8.5 7.8 1.2 7.7 7.8 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 CDI79921.1 - 0.8 9.6 6.1 1.4 8.9 6.1 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Transketolase_C PF02780.20 CDI79922.1 - 6.2e-38 129.5 0.3 8.7e-38 129.0 0.3 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CDI79922.1 - 8.4e-26 90.7 0.0 1.4e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 CDI79922.1 - 0.036 14.4 0.1 0.054 13.8 0.1 1.3 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Thiamine_BP PF01910.17 CDI79922.1 - 0.14 12.1 0.3 0.3 11.0 0.2 1.6 2 0 0 2 2 2 0 Thiamine-binding protein TLD PF07534.16 CDI79923.1 - 2e-21 76.7 0.0 3.1e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 CDI79923.1 - 7.7e-07 29.0 0.1 7.7e-07 29.0 0.1 3.2 4 0 0 4 4 4 2 Rab-GTPase-TBC domain Ofd1_CTDD PF10637.9 CDI79923.1 - 0.82 9.0 8.2 0.44 9.9 2.1 2.3 2 0 0 2 2 2 0 Oxoglutarate and iron-dependent oxygenase degradation C-term TetR_C_28 PF17937.1 CDI79925.1 - 0.014 15.8 1.3 0.094 13.2 0.0 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain FbpC_C_terminal PF17845.1 CDI79925.1 - 0.084 13.0 0.5 0.18 11.9 0.5 1.5 1 0 0 1 1 1 0 FbpC C-terminal regulatory nucleotide binding domain Fmp27_WPPW PF10359.9 CDI79928.1 - 4.7 5.9 8.3 0.5 9.2 2.4 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Wtap PF17098.5 CDI79929.1 - 0.044 13.7 0.6 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 WTAP/Mum2p family UCH_1 PF13423.6 CDI79930.1 - 4.9e-09 36.2 0.0 4.9e-09 36.2 0.0 3.8 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase DDHD PF02862.17 CDI79930.1 - 0.00038 20.7 20.4 0.019 15.1 3.2 3.5 3 0 0 3 3 3 2 DDHD domain Adaptin_binding PF10199.9 CDI79930.1 - 0.00063 20.3 9.9 0.018 15.6 0.2 2.9 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 DUF3801 PF12687.7 CDI79930.1 - 0.01 16.0 14.1 0.024 14.7 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) DUF2052 PF09747.9 CDI79930.1 - 0.036 14.2 24.1 0.75 9.9 11.2 2.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Isy1 PF06246.12 CDI79930.1 - 0.13 11.8 21.9 0.83 9.2 4.3 2.5 2 0 0 2 2 2 0 Isy1-like splicing family Vfa1 PF08432.10 CDI79930.1 - 0.15 12.4 23.1 0.86 9.9 11.1 2.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CLN3 PF02487.17 CDI79930.1 - 0.16 11.0 11.3 0.26 10.3 5.3 2.5 2 0 0 2 2 2 0 CLN3 protein Presenilin PF01080.17 CDI79930.1 - 0.28 9.9 39.0 0.0067 15.2 5.4 3.1 3 0 0 3 3 3 0 Presenilin RNase_H2_suC PF08615.11 CDI79930.1 - 0.32 11.2 7.9 0.079 13.1 0.3 2.5 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SpoIIP PF07454.11 CDI79930.1 - 0.65 9.4 20.3 0.34 10.3 10.2 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF4770 PF15994.5 CDI79930.1 - 0.68 10.2 16.4 2.9 8.1 7.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF2151 PF10221.9 CDI79930.1 - 0.77 8.3 10.5 0.22 10.1 1.4 2.2 2 0 0 2 2 2 0 Cell cycle and development regulator HNOBA PF07701.14 CDI79930.1 - 1 8.8 9.1 0.47 9.8 1.3 2.4 2 0 0 2 2 2 0 Heme NO binding associated AAA_11 PF13086.6 CDI79930.1 - 2.6 7.8 19.3 3.5 7.3 1.9 2.6 2 0 0 2 2 2 0 AAA domain NPR3 PF03666.13 CDI79930.1 - 3.4 6.4 24.3 0.0094 14.8 3.9 2.9 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 CDI79930.1 - 3.9 6.6 9.5 2.7 7.1 2.4 2.7 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4471 PF14740.6 CDI79930.1 - 4.5 6.4 10.4 0.39 9.9 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF2126 PF09899.9 CDI79930.1 - 8.3 4.3 12.0 5.3 5.0 0.3 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) Prefoldin_2 PF01920.20 CDI79931.1 - 1.9e-20 72.8 1.8 2.6e-20 72.3 1.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit APG6_N PF17675.1 CDI79931.1 - 0.0015 19.1 6.4 0.14 12.7 0.9 2.2 2 0 0 2 2 2 2 Apg6 coiled-coil region DUF615 PF04751.14 CDI79931.1 - 0.0033 17.4 5.5 0.0044 17.0 5.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF615) TMF_DNA_bd PF12329.8 CDI79931.1 - 0.0038 17.2 4.6 0.066 13.2 1.0 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.17 CDI79931.1 - 0.0059 16.5 1.7 0.57 10.1 0.0 2.2 2 0 0 2 2 2 1 Prefoldin subunit DUF1043 PF06295.12 CDI79931.1 - 0.0061 16.6 0.2 0.0061 16.6 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1043) Helo_like_N PF17111.5 CDI79931.1 - 0.01 15.2 3.7 0.096 12.0 0.1 2.1 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins NYD-SP28 PF14772.6 CDI79931.1 - 0.012 15.7 0.5 0.41 10.7 0.0 2.3 2 0 0 2 2 2 0 Sperm tail CdvA PF18822.1 CDI79931.1 - 0.017 14.9 3.1 0.74 9.7 0.1 2.1 2 0 0 2 2 2 0 CdvA-like coiled-coil domain EzrA PF06160.12 CDI79931.1 - 0.021 13.0 0.2 0.035 12.3 0.2 1.3 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Filament PF00038.21 CDI79931.1 - 0.031 13.9 3.5 0.21 11.1 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein DUF3138 PF11336.8 CDI79931.1 - 0.062 11.9 6.3 0.087 11.4 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Fib_alpha PF08702.10 CDI79931.1 - 0.065 13.4 0.8 1.5 9.0 0.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4600 PF15372.6 CDI79931.1 - 0.073 13.5 1.1 3.8 7.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) GAS PF13851.6 CDI79931.1 - 0.079 12.3 4.0 2.1 7.7 1.0 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.22 CDI79931.1 - 0.079 13.2 2.4 4.3 7.6 0.1 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.6 CDI79931.1 - 0.09 13.2 8.2 1.9 9.0 0.4 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4618 PF15397.6 CDI79931.1 - 0.11 11.9 3.2 0.2 11.1 3.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Spc24 PF08286.11 CDI79931.1 - 0.11 12.8 2.1 9.6 6.5 0.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4407 PF14362.6 CDI79931.1 - 0.13 11.6 6.2 0.19 11.1 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG2 PF06148.11 CDI79931.1 - 0.15 12.2 2.0 0.26 11.4 0.2 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ABC_tran_CTD PF16326.5 CDI79931.1 - 0.2 11.9 8.0 3.1 8.1 0.4 2.7 2 1 0 2 2 2 0 ABC transporter C-terminal domain PRKG1_interact PF15898.5 CDI79931.1 - 0.34 11.8 4.2 3.1 8.7 0.4 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Spc7 PF08317.11 CDI79931.1 - 0.75 8.6 5.0 6.2 5.6 0.3 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Dynamitin PF04912.14 CDI79931.1 - 0.99 8.7 8.4 19 4.4 8.4 2.0 1 1 0 1 1 1 0 Dynamitin Nnf1 PF03980.14 CDI79931.1 - 2.1 8.7 10.2 9.3 6.7 0.6 2.3 2 0 0 2 2 2 0 Nnf1 Csm1_N PF18504.1 CDI79931.1 - 3.1 8.2 8.5 1.9 8.9 0.4 2.5 2 1 0 2 2 2 0 Csm1 N-terminal domain DivIC PF04977.15 CDI79931.1 - 7.9 6.3 9.9 3.1 7.6 1.3 2.4 2 1 0 2 2 2 0 Septum formation initiator MerR-DNA-bind PF09278.11 CDI79931.1 - 8.2 7.0 9.9 4.9 7.8 1.8 2.6 3 0 0 3 3 2 0 MerR, DNA binding CASP_C PF08172.12 CDI79931.1 - 8.3 5.7 7.6 18 4.6 2.3 2.1 2 0 0 2 2 2 0 CASP C terminal Importin_rep_4 PF18808.1 CDI79932.1 - 1.5e-07 31.5 0.0 1.7e-06 28.2 0.0 2.9 3 0 0 3 3 3 1 Importin repeat Vac14_Fab1_bd PF12755.7 CDI79932.1 - 1.6e-07 31.9 0.0 5.7e-05 23.6 0.0 3.9 3 1 2 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CDI79932.1 - 6.3e-07 29.8 6.1 0.00019 21.9 0.6 10.3 6 3 4 11 11 11 4 HEAT-like repeat Cnd1 PF12717.7 CDI79932.1 - 0.00011 22.3 1.5 0.01 15.9 0.0 3.4 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CDI79932.1 - 0.00058 19.9 22.0 0.0029 17.7 0.1 8.7 9 0 0 9 9 9 1 HEAT repeat SUIM_assoc PF16619.5 CDI79932.1 - 0.012 15.6 4.0 0.018 15.1 1.8 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SopA_C PF13979.6 CDI79932.1 - 0.023 14.4 1.1 0.22 11.3 0.1 2.8 2 1 0 2 2 2 0 SopA-like catalytic domain BP28CT PF08146.12 CDI79932.1 - 0.06 13.2 0.8 0.8 9.5 0.0 3.2 2 1 0 2 2 2 0 BP28CT (NUC211) domain Macoilin PF09726.9 CDI79934.1 - 0.12 10.9 42.3 0.17 10.4 42.3 1.2 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 CDI79934.1 - 5.5 5.6 44.4 2.2 6.9 23.5 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup V_ATPase_I PF01496.19 CDI79934.1 - 6.9 4.5 56.0 0.63 7.9 24.8 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Trehalose_PPase PF02358.16 CDI79935.1 - 8.4e-27 93.8 0.0 4.2e-15 55.5 0.0 2.5 1 1 1 2 2 2 2 Trehalose-phosphatase Alba PF01918.21 CDI79935.1 - 0.0099 15.7 0.0 0.073 12.9 0.0 2.2 2 0 0 2 2 2 1 Alba Hydrolase_3 PF08282.12 CDI79935.1 - 0.017 14.9 0.1 0.44 10.3 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase SARAF PF06682.12 CDI79935.1 - 0.13 11.9 11.0 0.19 11.4 11.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Neur_chan_memb PF02932.16 CDI79935.1 - 0.61 10.1 3.2 1 9.4 3.2 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region zf-CCCH PF00642.24 CDI79936.1 - 2.7e-06 27.1 4.3 5.8e-06 26.1 4.3 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CDI79936.1 - 0.00014 22.5 0.3 0.00014 22.5 0.3 3.4 4 0 0 4 4 4 1 Torus domain zf_CCCH_4 PF18345.1 CDI79936.1 - 0.0013 18.7 6.6 0.0027 17.7 6.6 1.5 1 0 0 1 1 1 1 Zinc finger domain DUF1635 PF07795.11 CDI79936.1 - 0.0016 18.3 8.0 0.0016 18.3 8.0 4.6 2 1 1 3 3 3 1 Protein of unknown function (DUF1635) zf-CCCH_4 PF18044.1 CDI79936.1 - 0.014 15.2 3.8 0.029 14.2 3.8 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger TFIIA PF03153.13 CDI79937.1 - 0.11 12.4 64.2 0.17 11.9 64.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spc7_N PF15402.6 CDI79937.1 - 0.12 10.7 22.8 0.16 10.2 22.8 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 MMR1 PF08505.10 CDI79937.1 - 0.39 11.0 32.0 0.47 10.7 32.0 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein GAGA_bind PF06217.12 CDI79937.1 - 0.42 10.9 22.6 0.5 10.6 22.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 CDI79937.1 - 0.61 8.8 34.3 0.71 8.6 34.3 1.1 1 0 0 1 1 1 0 Presenilin Cwf_Cwc_15 PF04889.12 CDI79937.1 - 0.9 9.2 27.5 1.4 8.6 27.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4045 PF13254.6 CDI79937.1 - 1.4 8.4 32.6 1.8 8.1 32.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3807 PF12720.7 CDI79937.1 - 1.5 9.0 34.8 2.5 8.4 34.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) PAT1 PF09770.9 CDI79937.1 - 1.6 6.9 49.9 1.8 6.8 49.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI79937.1 - 2.4 5.2 28.0 2.5 5.1 28.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 CDI79937.1 - 2.6 6.8 20.5 3.2 6.5 20.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Draxin PF15550.6 CDI79937.1 - 3 7.6 18.7 3.6 7.4 18.7 1.0 1 0 0 1 1 1 0 Draxin Dapper PF15268.6 CDI79937.1 - 3.4 6.4 33.2 3.8 6.2 33.2 1.0 1 0 0 1 1 1 0 Dapper LAP1C PF05609.12 CDI79937.1 - 4.5 6.2 28.0 5.1 6.1 28.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) eIF-3_zeta PF05091.12 CDI79937.1 - 5.1 6.0 30.8 9.2 5.1 30.8 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hydin_ADK PF17213.3 CDI79937.1 - 5.8 7.1 24.6 8.6 6.6 24.6 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain BAF1_ABF1 PF04684.13 CDI79937.1 - 6.7 5.6 25.6 10 5.0 25.6 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF1387 PF07139.11 CDI79937.1 - 7.2 6.3 27.4 11 5.6 27.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CDC45 PF02724.14 CDI79937.1 - 9.1 4.4 26.4 11 4.2 26.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SRP-alpha_N PF04086.13 CDI79937.1 - 9.2 6.1 29.5 12 5.7 29.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Dicty_REP PF05086.12 CDI79937.1 - 9.4 4.1 17.2 11 3.9 17.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein WTX PF09422.10 CDI79937.1 - 9.6 5.2 23.3 11 4.9 23.3 1.2 1 0 0 1 1 1 0 WTX protein NTP_transf_2 PF01909.23 CDI79938.1 - 1.1e-05 25.6 0.1 4.2e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain PTPRCAP PF15713.5 CDI79938.1 - 0.0059 16.9 0.3 0.013 15.7 0.3 1.6 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated MecA PF05389.12 CDI79938.1 - 0.015 14.9 0.5 0.025 14.2 0.5 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF2722 PF10846.8 CDI79938.1 - 0.027 13.4 10.3 0.048 12.6 10.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) K_channel_TID PF07941.11 CDI79938.1 - 0.12 12.9 0.4 0.12 12.9 0.4 5.8 4 3 0 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain PAP_assoc PF03828.19 CDI79938.1 - 0.18 12.0 0.2 0.5 10.6 0.2 1.7 1 0 0 1 1 1 0 Cid1 family poly A polymerase Presenilin PF01080.17 CDI79938.1 - 0.2 10.4 0.6 0.3 9.8 0.6 1.2 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI79938.1 - 0.23 11.1 16.9 0.44 10.1 16.9 1.4 1 0 0 1 1 1 0 Spt20 family Peptidase_S49_N PF08496.10 CDI79938.1 - 0.67 10.0 5.8 1.4 9.0 5.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TMEM208_SND2 PF05620.11 CDI79938.1 - 2.2 8.1 5.0 4.4 7.1 5.0 1.5 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 CLPTM1 PF05602.12 CDI79939.1 - 6.1e-06 25.5 0.1 0.0037 16.3 0.0 2.1 2 0 0 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) OxoGdeHyase_C PF16870.5 CDI79940.1 - 2.8e-48 163.5 2.1 8.4e-48 161.9 0.0 2.1 2 1 0 2 2 1 1 2-oxoglutarate dehydrogenase C-terminal AAA_23 PF13476.6 CDI79940.1 - 0.0021 18.6 3.0 0.0021 18.6 3.0 1.2 1 0 0 1 1 1 1 AAA domain DUF2828 PF11443.8 CDI79940.1 - 0.009 14.2 3.2 0.01 14.0 3.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) DDHD PF02862.17 CDI79940.1 - 0.015 15.5 1.5 0.017 15.3 1.5 1.2 1 0 0 1 1 1 0 DDHD domain DUF853 PF05872.12 CDI79940.1 - 0.32 9.5 4.5 0.41 9.2 4.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Neur_chan_memb PF02932.16 CDI79940.1 - 0.37 10.8 1.8 0.42 10.6 1.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 CDI79940.1 - 0.39 10.1 14.7 0.52 9.7 14.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TERB2 PF15101.6 CDI79940.1 - 0.42 10.6 12.7 4.9 7.2 13.1 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 FAM60A PF15396.6 CDI79940.1 - 0.43 10.6 7.9 11 5.9 6.6 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Pannexin_like PF12534.8 CDI79940.1 - 0.73 8.9 6.4 0.98 8.4 6.4 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 RR_TM4-6 PF06459.12 CDI79940.1 - 0.78 9.5 10.9 1.1 9.1 10.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FYDLN_acid PF09538.10 CDI79940.1 - 0.95 10.2 12.0 3.8 8.2 9.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) CPSF100_C PF13299.6 CDI79940.1 - 1 9.5 8.6 1.4 9.0 8.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 CDI79940.1 - 1.2 7.0 7.8 1.4 6.7 7.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SpoIIP PF07454.11 CDI79940.1 - 1.5 8.2 11.4 2.1 7.7 11.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2098 PF09871.9 CDI79940.1 - 2.1 8.7 7.9 3.6 8.0 7.9 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Presenilin PF01080.17 CDI79940.1 - 2.5 6.8 11.4 2.9 6.6 11.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI79940.1 - 2.9 8.9 9.9 4.8 8.2 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EIIBC-GUT_N PF03612.14 CDI79940.1 - 3.4 7.4 10.8 5.5 6.7 10.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus NEMP PF10225.9 CDI79940.1 - 4.4 6.9 4.5 6 6.4 4.5 1.1 1 0 0 1 1 1 0 NEMP family FAM176 PF14851.6 CDI79940.1 - 5.9 6.5 9.8 10 5.8 9.8 1.3 1 0 0 1 1 1 0 FAM176 family Band_3_cyto PF07565.13 CDI79940.1 - 6.6 6.5 9.9 9.2 6.0 9.9 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Sec62 PF03839.16 CDI79940.1 - 6.7 6.1 10.1 11 5.5 10.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2347 PF09804.9 CDI79940.1 - 9.2 5.7 8.7 15 5.1 8.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) MAP7 PF05672.11 CDI79941.1 - 0.0018 18.0 10.4 0.0026 17.5 10.4 1.1 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family LRR_6 PF13516.6 CDI79941.1 - 0.0045 16.9 2.5 0.066 13.3 0.7 2.9 2 0 0 2 2 2 1 Leucine Rich repeat LRR_4 PF12799.7 CDI79941.1 - 0.044 14.2 1.2 3.1 8.4 0.2 2.8 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) DUF755 PF05501.11 CDI79941.1 - 0.24 11.7 18.6 0.43 10.8 18.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Activator_LAG-3 PF11498.8 CDI79941.1 - 7 5.5 22.4 9.9 5.0 22.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 IMUP PF15761.5 CDI79941.1 - 7.6 7.3 9.5 13 6.5 9.5 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein BNIP3 PF06553.12 CDI79942.1 - 0.0038 16.9 0.9 0.0038 16.9 0.9 2.6 2 0 0 2 2 2 1 BNIP3 RNA_pol_3_Rpc31 PF11705.8 CDI79942.1 - 0.074 13.3 0.3 0.074 13.3 0.3 3.0 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 Abi_C PF14355.6 CDI79942.1 - 1.6 8.9 7.6 11 6.2 0.3 3.4 3 0 0 3 3 3 0 Abortive infection C-terminus PPP4R2 PF09184.11 CDI79942.1 - 3 7.4 11.2 6.2 6.3 0.2 2.6 2 0 0 2 2 2 0 PPP4R2 RXT2_N PF08595.11 CDI79942.1 - 8 6.5 14.6 3.5 7.6 4.7 2.8 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF5531 PF17671.1 CDI79943.1 - 0.012 15.5 0.1 0.041 13.8 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5531) ABC2_membrane_3 PF12698.7 CDI79943.1 - 0.14 11.2 0.1 0.31 10.1 0.1 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein TFIIA PF03153.13 CDI79946.1 - 0.52 10.3 28.6 9.3 6.1 0.0 3.1 1 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit LRR_4 PF12799.7 CDI79947.1 - 1.4e-13 50.7 1.6 4.4e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI79947.1 - 1.1e-06 28.3 1.3 0.042 13.6 0.3 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 CDI79947.1 - 1.3e-06 28.0 0.2 3.9e-06 26.5 0.2 1.7 1 0 0 1 1 1 1 Leucine-rich repeat TFIIA PF03153.13 CDI79948.1 - 0.0016 18.5 46.5 0.0051 16.9 23.0 2.5 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 CDI79948.1 - 0.0017 18.2 12.9 0.1 12.3 0.4 3.5 3 0 0 3 3 3 2 Cwf15/Cwc15 cell cycle control protein DUF1645 PF07816.11 CDI79948.1 - 0.0084 16.7 11.4 0.0084 16.7 11.4 6.0 6 1 0 6 6 6 1 Protein of unknown function (DUF1645) DUF21 PF01595.20 CDI79948.1 - 0.046 13.4 4.4 0.048 13.4 2.3 2.2 1 1 1 2 2 2 0 Cyclin M transmembrane N-terminal domain V_ATPase_I PF01496.19 CDI79950.1 - 0.0053 14.7 15.4 0.0056 14.7 15.4 1.3 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SOBP PF15279.6 CDI79950.1 - 0.026 15.1 27.1 0.032 14.8 27.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI79950.1 - 0.037 12.3 50.9 0.044 12.1 50.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI79950.1 - 0.1 10.9 21.1 0.12 10.7 21.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Exonuc_VII_L PF02601.15 CDI79950.1 - 0.11 12.0 29.1 0.15 11.6 29.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Endostatin PF06482.11 CDI79950.1 - 0.39 10.1 22.8 0.54 9.7 22.8 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Zip PF02535.22 CDI79950.1 - 0.4 9.8 10.1 0.51 9.5 10.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Joubert PF15392.6 CDI79950.1 - 0.47 10.1 31.3 0.59 9.8 31.3 1.2 1 0 0 1 1 1 0 Joubert syndrome-associated Paramyxo_ncap PF00973.19 CDI79950.1 - 0.5 9.2 21.8 0.63 8.9 21.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Membralin PF09746.9 CDI79950.1 - 0.68 8.9 15.5 0.85 8.6 15.5 1.3 1 0 0 1 1 1 0 Tumour-associated protein eIF-3_zeta PF05091.12 CDI79950.1 - 0.78 8.6 31.2 1.1 8.1 31.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peptidase_S15 PF02129.18 CDI79950.1 - 1.2 8.6 16.4 1.8 8.1 16.4 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) LicD PF04991.13 CDI79950.1 - 1.4 9.0 9.6 2.6 8.1 9.6 1.5 1 0 0 1 1 1 0 LicD family Nop53 PF07767.11 CDI79950.1 - 1.9 7.8 42.5 3.1 7.1 42.5 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Med15 PF09606.10 CDI79950.1 - 2.5 6.7 53.5 3.5 6.2 53.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PMSI1 PF15322.6 CDI79950.1 - 2.6 7.4 19.9 3.7 6.9 19.9 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Cellulose_synt PF03552.14 CDI79950.1 - 2.6 6.4 10.3 3.4 6.0 10.3 1.1 1 0 0 1 1 1 0 Cellulose synthase FAM222A PF15258.6 CDI79950.1 - 3.2 6.8 36.8 4.2 6.4 36.8 1.4 1 0 0 1 1 1 0 Protein family of FAM222A BAF1_ABF1 PF04684.13 CDI79950.1 - 3.8 6.5 32.1 5.1 6.0 32.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Draxin PF15550.6 CDI79950.1 - 4.8 7.0 24.1 7 6.4 24.1 1.3 1 0 0 1 1 1 0 Draxin DUF4045 PF13254.6 CDI79950.1 - 6.9 6.2 33.4 9.7 5.7 33.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) GREB1 PF15782.5 CDI79950.1 - 7.1 3.6 35.8 7.9 3.4 35.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3584 PF12128.8 CDI79950.1 - 8.6 3.7 46.0 10 3.4 46.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Kinesin PF00225.23 CDI79951.1 - 2.4e-78 263.4 6.7 2.4e-78 263.4 6.7 6.0 4 2 1 6 6 6 1 Kinesin motor domain Microtub_bd PF16796.5 CDI79951.1 - 1e-15 58.0 14.2 1.4e-14 54.3 2.0 4.4 3 0 0 3 3 3 2 Microtubule binding UQ_con PF00179.26 CDI79952.1 - 0.0019 17.9 0.1 0.0045 16.6 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme TFIIA PF03153.13 CDI79952.1 - 0.0066 16.5 26.8 0.0086 16.1 26.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SpoIIIAH PF12685.7 CDI79952.1 - 0.62 9.9 22.7 0.033 14.0 4.6 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein Apt1 PF10351.9 CDI79952.1 - 0.72 8.6 22.5 0.34 9.7 8.7 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 CDI79952.1 - 0.88 8.9 13.1 0.81 9.0 5.2 2.1 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF966 PF06136.13 CDI79952.1 - 1.2 8.8 25.0 0.84 9.3 7.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) CCSAP PF15748.5 CDI79952.1 - 1.7 8.7 24.5 3.4 7.8 9.2 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF4667 PF15700.5 CDI79952.1 - 1.9 8.5 36.4 2.8 8.0 15.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Lin-8 PF03353.15 CDI79952.1 - 2.6 7.6 18.9 0.066 12.8 7.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SRP-alpha_N PF04086.13 CDI79952.1 - 3.1 7.6 22.8 0.7 9.8 7.5 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal FAM176 PF14851.6 CDI79952.1 - 4.7 6.9 7.2 1.4 8.5 1.8 2.2 2 0 0 2 2 2 0 FAM176 family Nucleoplasmin PF03066.15 CDI79953.1 - 0.12 12.9 0.2 0.34 11.4 0.2 1.7 1 0 0 1 1 1 0 Nucleoplasmin/nucleophosmin domain Gram_pos_anchor PF00746.21 CDI79953.1 - 0.13 12.2 0.5 0.35 10.9 0.5 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Mito_carr PF00153.27 CDI79954.1 - 1.3e-31 108.4 3.1 3e-12 46.3 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Not3 PF04065.15 CDI79955.1 - 3.3e-60 203.4 4.6 3.3e-60 203.4 4.6 1.6 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 CDI79955.1 - 2e-27 95.9 0.2 2e-27 95.9 0.2 2.0 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family eIF3_N PF09440.10 CDI79955.1 - 0.22 11.9 8.2 0.041 14.3 2.8 2.3 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain 4HB_MCP_1 PF12729.7 CDI79955.1 - 3.1 7.3 8.2 0.3 10.6 2.9 2.0 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Spore_III_AB PF09548.10 CDI79955.1 - 8.8 6.4 9.8 5 7.2 4.1 2.9 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Pkinase PF00069.25 CDI79956.1 - 2.1e-05 24.0 0.1 5.2e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79956.1 - 0.006 15.9 0.1 0.013 14.9 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Otopetrin PF03189.13 CDI79956.1 - 0.11 11.3 0.0 12 4.6 0.0 3.2 2 2 0 2 2 2 0 Otopetrin DUF4574 PF15141.6 CDI79957.1 - 0.021 14.7 2.8 0.021 14.7 2.8 3.3 1 1 1 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 CDC45 PF02724.14 CDI79957.1 - 0.38 9.0 32.8 0.42 8.8 32.8 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI79957.1 - 6.9 5.6 39.4 7.8 5.4 39.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SRP-alpha_N PF04086.13 CDI79957.1 - 9.3 6.1 30.2 13 5.6 30.2 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Med15 PF09606.10 CDI79958.1 - 0.0018 17.1 14.8 0.0018 17.1 14.8 2.8 2 1 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI79958.1 - 0.0045 16.0 15.9 0.0045 16.0 15.9 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI79958.1 - 0.0097 15.5 23.1 0.0097 15.5 23.1 3.1 3 0 0 3 3 3 1 Spt20 family EOS1 PF12326.8 CDI79958.1 - 0.12 12.3 5.3 0.057 13.3 2.3 2.0 2 0 0 2 2 2 0 N-glycosylation protein MCU PF04678.13 CDI79958.1 - 0.6 10.2 6.4 0.3 11.2 3.8 1.8 2 0 0 2 2 2 0 Mitochondrial calcium uniporter UBA_e1_thiolCys PF10585.9 CDI79958.1 - 1.5 8.6 10.5 0.67 9.8 7.0 1.9 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site Dicty_REP PF05086.12 CDI79958.1 - 1.7 6.5 4.8 2.5 6.0 4.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4569 PF15133.6 CDI79958.1 - 3.7 7.2 14.5 1.3 8.7 10.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) RR_TM4-6 PF06459.12 CDI79958.1 - 9.4 6.0 11.7 3.9 7.2 6.3 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Proteasome PF00227.26 CDI79959.1 - 1.4e-19 70.3 0.0 2e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_60s PF00428.19 CDI79959.1 - 9.7 6.9 18.1 4.3 8.0 7.2 3.1 3 0 0 3 3 3 0 60s Acidic ribosomal protein SARAF PF06682.12 CDI79961.1 - 0.00029 20.6 0.4 0.00029 20.6 0.4 5.1 4 1 1 5 5 5 1 SOCE-associated regulatory factor of calcium homoeostasis Suf PF05843.14 CDI79961.1 - 0.00072 19.6 6.3 0.00072 19.6 6.3 4.3 4 1 0 4 4 4 1 Suppressor of forked protein (Suf) Velvet PF11754.8 CDI79961.1 - 0.0088 16.0 0.9 0.0088 16.0 0.9 4.4 2 1 0 2 2 2 1 Velvet factor Hyccin PF09790.9 CDI79961.1 - 0.014 14.5 0.1 0.044 12.9 0.1 1.8 1 0 0 1 1 1 0 Hyccin CSG2 PF16965.5 CDI79961.1 - 0.3 10.0 4.4 0.14 11.1 0.1 2.5 3 0 0 3 3 3 0 Ceramide synthase regulator Activator_LAG-3 PF11498.8 CDI79962.1 - 0.00032 19.8 23.9 0.00032 19.8 23.9 3.7 4 0 0 4 4 4 1 Transcriptional activator LAG-3 Creatininase PF02633.14 CDI79962.1 - 0.069 12.6 0.2 0.18 11.2 0.2 1.6 1 0 0 1 1 1 0 Creatinine amidohydrolase TFIIA PF03153.13 CDI79962.1 - 0.1 12.5 55.0 0.54 10.2 7.4 4.1 4 0 0 4 4 4 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI79962.1 - 0.18 10.7 32.2 0.18 10.7 0.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) DUF3371 PF11851.8 CDI79962.1 - 6.6 7.8 20.7 1.4 10.0 3.5 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3371) Syja_N PF02383.18 CDI79963.1 - 7.3e-27 94.5 11.5 1.5e-19 70.5 2.1 5.9 3 2 1 4 4 4 3 SacI homology domain Mucin PF01456.17 CDI79963.1 - 0.021 14.8 0.2 0.021 14.8 0.2 8.0 7 1 1 8 8 8 0 Mucin-like glycoprotein Abi_2 PF07751.11 CDI79963.1 - 0.2 11.9 13.7 0.69 10.2 5.8 3.6 3 0 0 3 3 3 0 Abi-like protein RskA PF10099.9 CDI79963.1 - 8.5 6.6 0.0 0.047 14.0 7.4 15.7 5 4 7 13 13 13 0 Anti-sigma-K factor rskA BTB PF00651.31 CDI79965.1 - 6.3e-13 48.9 0.0 8.9e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 CDI79965.1 - 0.00088 19.5 0.0 0.018 15.3 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI79965.1 - 0.0041 17.1 0.2 0.12 12.4 0.1 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 CDI79965.1 - 0.013 15.1 0.6 0.025 14.2 0.6 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.6 CDI79965.1 - 0.058 13.4 0.0 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain PIH1_CS PF18201.1 CDI79966.1 - 0.00027 21.3 0.0 0.00055 20.3 0.0 1.5 2 0 0 2 2 2 1 PIH1 CS-like domain V_ATPase_I PF01496.19 CDI79967.1 - 9.9e-189 629.1 0.0 4.4e-123 411.9 0.0 2.9 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family Spore_III_AB PF09548.10 CDI79967.1 - 0.0011 19.1 0.2 0.0099 16.0 0.1 2.7 2 0 0 2 2 2 1 Stage III sporulation protein AB (spore_III_AB) NicO PF03824.16 CDI79967.1 - 0.0053 16.1 0.6 0.016 14.5 0.6 1.8 1 0 0 1 1 1 1 High-affinity nickel-transport protein SPX PF03105.19 CDI79967.1 - 0.29 11.0 9.1 0.16 11.9 3.8 2.3 2 0 0 2 2 2 0 SPX domain CSRNP_N PF16019.5 CDI79967.1 - 1.2 9.0 6.4 4.2 7.2 1.0 2.4 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus TFIIA PF03153.13 CDI79967.1 - 5.2 7.0 38.5 2.2 8.2 14.7 3.0 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI79968.1 - 0.013 15.9 1.5 0.013 15.9 1.5 1.8 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI79968.1 - 0.04 13.9 10.2 0.047 13.7 10.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit THOC2_N PF16134.5 CDI79968.1 - 0.06 12.0 0.0 0.078 11.6 0.0 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Rsc14 PF08586.10 CDI79968.1 - 0.073 13.9 1.9 0.12 13.2 1.9 1.3 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit eIF-3_zeta PF05091.12 CDI79968.1 - 0.095 11.7 3.5 0.11 11.4 3.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Med3 PF11593.8 CDI79968.1 - 0.11 11.6 6.9 0.13 11.4 6.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4834 PF16118.5 CDI79968.1 - 6.9 7.7 7.1 2.1 9.3 4.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Abhydrolase_1 PF00561.20 CDI79969.1 - 0.011 15.3 0.0 0.8 9.3 0.0 2.7 3 0 0 3 3 3 0 alpha/beta hydrolase fold DUF2722 PF10846.8 CDI79969.1 - 0.056 12.4 1.7 0.25 10.2 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI79969.1 - 0.18 11.7 7.2 0.38 10.7 1.0 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI79969.1 - 0.36 10.4 10.4 0.61 9.7 5.4 2.2 2 0 0 2 2 2 0 Spt20 family DDHD PF02862.17 CDI79970.1 - 1e-05 25.9 8.9 1.3e-05 25.5 8.9 1.2 1 0 0 1 1 1 1 DDHD domain RNA_pol_Rpc4 PF05132.14 CDI79970.1 - 4.5e-05 23.9 6.6 4.5e-05 23.9 6.6 1.4 2 0 0 2 2 1 1 RNA polymerase III RPC4 Pex14_N PF04695.13 CDI79970.1 - 6.2e-05 23.7 21.8 8.5e-05 23.3 21.8 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI79970.1 - 7e-05 22.4 12.3 7.8e-05 22.3 12.3 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 CDI79970.1 - 0.00015 20.7 16.8 0.00019 20.4 16.8 1.2 1 0 0 1 1 1 1 Presenilin RR_TM4-6 PF06459.12 CDI79970.1 - 0.00018 21.4 13.4 0.00026 20.9 13.4 1.3 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 CDI79970.1 - 0.0004 18.6 11.5 0.0004 18.6 11.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Velvet PF11754.8 CDI79970.1 - 0.00042 20.3 10.7 0.00043 20.3 10.7 1.2 1 0 0 1 1 1 1 Velvet factor TFIIA PF03153.13 CDI79970.1 - 0.00046 20.3 42.5 0.00067 19.8 42.5 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Band_3_cyto PF07565.13 CDI79970.1 - 0.00075 19.4 15.3 0.00096 19.0 15.3 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain CCDC53 PF10152.9 CDI79970.1 - 0.00088 19.7 13.5 0.0015 19.0 13.5 1.4 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex DUF913 PF06025.12 CDI79970.1 - 0.0011 18.1 6.2 0.0012 17.9 6.2 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Mgr1 PF08602.10 CDI79970.1 - 0.0013 17.6 2.3 0.0016 17.3 2.3 1.1 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit CSG2 PF16965.5 CDI79970.1 - 0.0016 17.5 6.8 0.0021 17.1 6.8 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator Scs3p PF10261.9 CDI79970.1 - 0.0018 17.8 3.1 0.0026 17.3 3.1 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM BORG_CEP PF14957.6 CDI79970.1 - 0.0019 19.3 7.1 0.0023 19.1 7.1 1.3 1 0 0 1 1 1 1 Cdc42 effector CDC45 PF02724.14 CDI79970.1 - 0.0031 15.9 13.0 0.0032 15.9 13.0 1.1 1 0 0 1 1 1 1 CDC45-like protein Connexin PF00029.19 CDI79970.1 - 0.0033 17.2 15.5 0.0046 16.8 15.5 1.3 1 0 0 1 1 1 1 Connexin SLC12 PF03522.15 CDI79970.1 - 0.0035 16.4 16.9 0.0037 16.4 16.9 1.1 1 0 0 1 1 1 1 Solute carrier family 12 PAT1 PF09770.9 CDI79970.1 - 0.0045 15.3 29.8 0.0048 15.3 29.8 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 NPR3 PF03666.13 CDI79970.1 - 0.0047 15.8 14.9 0.0054 15.6 14.9 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF2126 PF09899.9 CDI79970.1 - 0.0051 15.0 8.6 0.0055 14.9 8.6 1.0 1 0 0 1 1 1 1 Putative amidoligase enzyme (DUF2126) PIP5K PF01504.18 CDI79970.1 - 0.0059 15.9 11.2 0.0079 15.5 11.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase ALMT PF11744.8 CDI79970.1 - 0.0065 15.4 10.4 0.0075 15.2 10.4 1.1 1 0 0 1 1 1 1 Aluminium activated malate transporter V_ATPase_I PF01496.19 CDI79970.1 - 0.0066 14.4 17.5 0.008 14.2 17.5 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Nucleoside_tran PF01733.18 CDI79970.1 - 0.01 15.2 1.8 0.015 14.7 1.8 1.3 1 0 0 1 1 1 0 Nucleoside transporter DUF4746 PF15928.5 CDI79970.1 - 0.011 15.2 8.8 0.013 14.9 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CobT PF06213.12 CDI79970.1 - 0.016 14.6 25.1 0.022 14.1 25.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2370 PF10176.9 CDI79970.1 - 0.016 14.8 8.1 0.021 14.5 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Hid1 PF12722.7 CDI79970.1 - 0.019 13.2 13.5 0.019 13.1 13.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LMBR1 PF04791.16 CDI79970.1 - 0.023 13.6 7.2 0.027 13.4 7.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CCSAP PF15748.5 CDI79970.1 - 0.028 14.6 22.4 0.035 14.3 22.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Zip PF02535.22 CDI79970.1 - 0.029 13.6 8.1 0.037 13.2 8.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MDM31_MDM32 PF08118.11 CDI79970.1 - 0.042 12.5 7.2 0.055 12.1 7.2 1.3 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Ureide_permease PF07168.11 CDI79970.1 - 0.044 12.5 3.9 0.053 12.3 3.9 1.2 1 0 0 1 1 1 0 Ureide permease Lin-8 PF03353.15 CDI79970.1 - 0.045 13.3 22.6 0.053 13.1 22.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LAP1C PF05609.12 CDI79970.1 - 0.07 12.2 19.9 0.082 12.0 19.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 CDI79970.1 - 0.079 10.1 16.2 0.079 10.1 16.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Borrelia_P83 PF05262.11 CDI79970.1 - 0.087 11.3 20.4 0.088 11.3 20.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3292 PF11696.8 CDI79970.1 - 0.087 11.2 8.7 0.11 10.9 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) HCO3_cotransp PF00955.21 CDI79970.1 - 0.11 11.3 7.5 0.14 10.9 7.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family CAF1 PF04857.20 CDI79970.1 - 0.13 11.4 11.1 0.15 11.2 11.1 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease Spore_coat_CotO PF14153.6 CDI79970.1 - 0.16 11.9 26.6 0.08 12.9 24.4 1.7 3 0 0 3 3 1 0 Spore coat protein CotO BT1 PF03092.16 CDI79970.1 - 0.17 10.0 1.5 0.23 9.7 1.5 1.1 1 0 0 1 1 1 0 BT1 family Membralin PF09746.9 CDI79970.1 - 0.18 10.8 11.6 0.22 10.5 11.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein Ndc1_Nup PF09531.10 CDI79970.1 - 0.2 10.3 14.2 0.24 10.1 14.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MDFI PF15316.6 CDI79970.1 - 0.22 11.6 10.7 0.32 11.1 10.7 1.3 1 0 0 1 1 1 0 MyoD family inhibitor MDM10 PF12519.8 CDI79970.1 - 0.24 10.2 16.1 0.29 9.9 16.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 LicD PF04991.13 CDI79970.1 - 0.25 11.5 5.4 0.32 11.1 5.4 1.2 1 0 0 1 1 1 0 LicD family Exonuc_VII_L PF02601.15 CDI79970.1 - 0.26 10.8 20.1 0.29 10.7 20.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit XRN_M PF17846.1 CDI79970.1 - 0.27 10.1 13.1 0.36 9.7 13.1 1.2 1 0 0 1 1 1 0 Xrn1 helical domain ABC2_membrane_3 PF12698.7 CDI79970.1 - 0.4 9.7 2.9 0.51 9.4 2.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Paf1 PF03985.13 CDI79970.1 - 0.45 9.5 24.1 0.67 8.9 24.1 1.3 1 0 0 1 1 1 0 Paf1 DUF4400 PF14348.6 CDI79970.1 - 0.47 9.9 1.6 0.64 9.5 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) PepSY_TM PF03929.16 CDI79970.1 - 0.5 10.0 7.6 0.69 9.5 7.6 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Peptidase_S64 PF08192.11 CDI79970.1 - 0.63 8.5 17.9 0.71 8.3 17.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4638 PF15472.6 CDI79970.1 - 0.67 9.6 20.2 0.85 9.3 20.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Afi1 PF07792.12 CDI79970.1 - 0.72 10.3 18.4 0.053 14.0 13.8 1.5 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MCU PF04678.13 CDI79970.1 - 0.79 9.8 12.3 1.5 8.9 12.3 1.5 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Cadherin_C_2 PF16492.5 CDI79970.1 - 0.86 10.4 0.1 0.86 10.4 0.1 2.8 2 1 0 2 2 1 0 Cadherin cytoplasmic C-terminal Cellulose_synt PF03552.14 CDI79970.1 - 1 7.8 7.9 1.1 7.6 7.9 1.1 1 0 0 1 1 1 0 Cellulose synthase MMU163 PF17119.5 CDI79970.1 - 1.1 8.4 8.3 1.9 7.6 8.3 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Tim54 PF11711.8 CDI79970.1 - 1.1 8.0 20.3 1.8 7.3 20.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Acatn PF13000.7 CDI79970.1 - 1.2 7.5 5.4 1.8 7.0 5.4 1.2 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 EIF4E-T PF10477.9 CDI79970.1 - 1.3 7.8 28.6 1.6 7.4 28.6 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E F-protein PF00469.20 CDI79970.1 - 1.8 8.1 16.7 2.6 7.6 16.7 1.2 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Gti1_Pac2 PF09729.9 CDI79970.1 - 1.9 8.6 20.2 3.3 7.8 20.2 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family ABC2_membrane_2 PF12679.7 CDI79970.1 - 2.1 7.5 6.3 3.3 6.9 6.3 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein PTPRCAP PF15713.5 CDI79970.1 - 2.3 8.5 22.1 3.6 7.9 22.1 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Plasmodium_Vir PF05795.11 CDI79970.1 - 2.4 7.5 9.5 2.6 7.4 9.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Rrn6 PF10214.9 CDI79970.1 - 2.4 6.5 28.2 2.9 6.3 28.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Orf78 PF06024.12 CDI79970.1 - 2.7 8.4 18.0 3.2e+02 1.7 18.0 2.2 1 1 0 1 1 1 0 Orf78 (ac78) SART-1 PF03343.13 CDI79970.1 - 2.7 6.5 32.6 4 5.9 32.6 1.2 1 0 0 1 1 1 0 SART-1 family AAA_23 PF13476.6 CDI79970.1 - 2.7 8.4 28.3 4.2 7.8 28.3 1.3 1 0 0 1 1 1 0 AAA domain Otopetrin PF03189.13 CDI79970.1 - 3.1 6.5 15.1 3.9 6.2 15.1 1.1 1 0 0 1 1 1 0 Otopetrin eIF-3_zeta PF05091.12 CDI79970.1 - 3.4 6.5 31.4 4.7 6.1 31.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARP1 PF12569.8 CDI79970.1 - 3.5 6.4 22.9 5 5.9 22.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Asparaginase_2 PF01112.18 CDI79970.1 - 4.2 6.3 10.2 7.5 5.5 10.2 1.4 1 0 0 1 1 1 0 Asparaginase DUF1980 PF09323.10 CDI79970.1 - 4.7 7.1 16.1 4.1 7.3 14.5 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF1980) STAC2_u1 PF16664.5 CDI79970.1 - 4.9 7.6 15.6 8.9 6.8 15.6 1.4 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Baculo_PP31 PF05311.11 CDI79970.1 - 5.4 6.4 22.4 0.44 10.0 18.0 1.4 2 0 0 2 2 1 0 Baculovirus 33KDa late protein (PP31) DUF2946 PF11162.8 CDI79970.1 - 5.5 7.7 14.8 26 5.5 14.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2946) MAJIN PF15077.6 CDI79970.1 - 7.8 6.2 17.2 12 5.6 17.2 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein UNC-79 PF14776.6 CDI79970.1 - 7.9 5.1 15.5 28 3.3 15.5 1.8 1 1 0 1 1 1 0 Cation-channel complex subunit UNC-79 Pal1 PF08316.11 CDI79970.1 - 8.3 7.2 12.9 14 6.4 12.9 1.4 1 0 0 1 1 1 0 Pal1 cell morphology protein DUF1501 PF07394.12 CDI79970.1 - 8.4 5.3 22.8 11 4.9 22.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PPR_long PF17177.4 CDI79971.1 - 0.12 11.7 4.3 0.16 11.3 4.3 1.1 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP DUF3112 PF11309.8 CDI79971.1 - 0.17 11.3 1.5 0.23 10.9 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Phosducin PF02114.16 CDI79971.1 - 1.8 7.4 7.3 2.2 7.2 7.3 1.1 1 0 0 1 1 1 0 Phosducin AP2 PF00847.20 CDI79972.1 - 1.3e-06 28.5 8.0 3.3e-06 27.2 0.6 3.6 3 0 0 3 3 3 2 AP2 domain Carb_kinase PF01256.17 CDI79974.1 - 5.1e-23 81.8 23.4 3.6e-17 62.7 0.0 5.6 5 1 1 6 6 6 3 Carbohydrate kinase SUIM_assoc PF16619.5 CDI79974.1 - 0.052 13.6 39.0 0.34 11.0 5.0 4.6 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI79974.1 - 5.5 6.5 32.7 1.9 8.0 6.1 4.1 4 0 0 4 4 4 0 Spt20 family Proteasome PF00227.26 CDI79975.1 - 5.5e-46 156.4 0.4 1.3e-39 135.7 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 CDI79975.1 - 1.3e-13 50.4 0.0 2.3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Pkinase PF00069.25 CDI79976.1 - 9.1e-38 130.1 0.0 1.9e-19 70.1 0.0 3.5 5 0 0 5 5 5 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI79976.1 - 1.4e-15 57.3 1.1 7.6e-08 31.9 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI79976.1 - 0.0034 16.2 0.0 0.0034 16.2 0.0 4.5 4 0 0 4 4 4 1 Fungal protein kinase DUF1744 PF08490.12 CDI79977.1 - 0.066 11.8 0.0 0.08 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) Hamartin PF04388.12 CDI79978.1 - 0.032 12.9 22.9 0.048 12.3 22.9 1.2 1 0 0 1 1 1 0 Hamartin protein PseudoU_synth_1 PF01416.20 CDI79979.1 - 1.6e-09 38.2 0.2 8e-08 32.7 0.1 2.8 2 0 0 2 2 2 1 tRNA pseudouridine synthase Apt1 PF10351.9 CDI79979.1 - 0.088 11.7 17.4 0.22 10.4 2.3 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Corona_nucleoca PF00937.18 CDI79979.1 - 0.17 10.9 27.1 0.084 11.9 8.1 2.4 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein RSRP PF17069.5 CDI79979.1 - 0.97 8.9 35.3 0.48 9.9 16.3 2.6 2 0 0 2 2 2 0 Arginine/Serine-Rich protein 1 SPX PF03105.19 CDI79979.1 - 4 7.3 27.5 1.9 8.3 12.0 2.3 2 0 0 2 2 2 0 SPX domain Enolase_N PF03952.16 CDI79979.1 - 4.9 7.3 8.1 14 5.9 0.1 2.7 2 1 0 2 2 2 0 Enolase, N-terminal domain Menin PF05053.13 CDI79979.1 - 9 4.5 27.0 0.22 9.9 16.3 2.1 2 0 0 2 2 2 0 Menin Zn_peptidase PF04228.13 CDI79983.1 - 0.091 12.2 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Kinesin PF00225.23 CDI79984.1 - 1.5e-08 34.0 11.2 1.5e-08 34.0 11.2 3.2 1 1 1 2 2 2 1 Kinesin motor domain SpoU_methylase PF00588.19 CDI79985.1 - 1.6e-16 60.8 0.0 1.1e-15 58.1 0.0 2.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family CDC45 PF02724.14 CDI79985.1 - 0.00011 20.6 3.2 0.00011 20.6 3.2 4.4 4 1 0 4 4 4 1 CDC45-like protein UPF0564 PF10595.9 CDI79985.1 - 0.0028 16.8 8.7 0.0028 16.8 8.7 6.0 7 0 0 7 7 7 1 Uncharacterised protein family UPF0564 SDA1 PF05285.12 CDI79985.1 - 0.0034 16.9 5.8 0.0034 16.9 5.8 4.5 3 1 0 3 3 3 1 SDA1 Zip PF02535.22 CDI79985.1 - 0.0035 16.6 1.8 0.0035 16.6 1.8 4.5 3 1 0 3 3 3 1 ZIP Zinc transporter Fig1 PF12351.8 CDI79985.1 - 0.0041 17.1 3.9 0.075 12.9 1.3 3.4 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 RPA43_OB PF17875.1 CDI79985.1 - 0.27 11.9 0.1 0.27 11.9 0.1 6.2 5 2 0 5 5 5 0 RPA43 OB domain in RNA Pol I RNA_Me_trans PF04252.13 CDI79987.1 - 0.025 14.1 0.3 0.025 14.1 0.3 1.8 2 0 0 2 2 2 0 Predicted SAM-dependent RNA methyltransferase Med15 PF09606.10 CDI79988.1 - 4e-05 22.6 34.1 0.0011 17.8 24.8 2.4 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI79988.1 - 0.0034 17.4 25.0 0.0034 17.4 25.0 3.0 2 1 0 2 2 1 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI79988.1 - 0.12 12.5 9.2 0.13 12.4 4.3 2.6 3 0 0 3 3 3 0 DDHD domain Hexokinase_2 PF03727.16 CDI79988.1 - 0.25 10.7 0.0 0.25 10.7 0.0 2.4 3 0 0 3 3 2 0 Hexokinase ETRAMP PF09716.10 CDI79988.1 - 0.3 11.2 4.2 11 6.1 0.0 3.8 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) OATP PF03137.20 CDI79988.1 - 0.3 9.3 1.4 0.65 8.2 1.4 1.5 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EPL1 PF10513.9 CDI79988.1 - 0.31 11.4 12.4 1.1 9.7 7.4 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like CCSAP PF15748.5 CDI79988.1 - 0.7 10.0 23.4 0.016 15.4 7.2 3.3 3 0 0 3 3 3 0 Centriole, cilia and spindle-associated GPCR_chapero_1 PF11904.8 CDI79988.1 - 1.1 8.6 8.9 3.3 7.0 4.8 2.2 2 0 0 2 2 2 0 GPCR-chaperone DUF572 PF04502.13 CDI79988.1 - 1.8 8.1 14.5 0.16 11.6 5.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF2052 PF09747.9 CDI79988.1 - 2.1 8.4 22.8 0.58 10.2 0.7 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) HI0933_like PF03486.14 CDI79988.1 - 3 6.4 7.9 1.2e+02 1.1 9.8 2.2 2 0 0 2 2 2 0 HI0933-like protein MMR1 PF08505.10 CDI79988.1 - 4.4 7.5 22.6 0.3 11.3 12.2 2.4 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Dicty_REP PF05086.12 CDI79988.1 - 6.2 4.7 6.0 9.6 4.0 6.0 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4778 PF16008.5 CDI79988.1 - 6.7 6.7 16.9 0.36 10.8 10.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) SUIM_assoc PF16619.5 CDI79989.1 - 0.14 12.3 0.0 0.14 12.3 0.0 6.7 3 3 3 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 TMEM65 PF10507.9 CDI79990.1 - 9e-15 54.6 3.7 9e-15 54.6 3.7 6.0 6 1 1 7 7 7 1 Transmembrane protein 65 Otopetrin PF03189.13 CDI79990.1 - 0.065 12.0 0.0 31 3.2 0.0 3.1 3 1 0 3 3 3 0 Otopetrin Peroxin-3 PF04882.12 CDI79991.1 - 0.00045 19.3 0.0 0.00045 19.3 0.0 4.2 2 1 2 4 4 4 1 Peroxin-3 eIF-3_zeta PF05091.12 CDI79991.1 - 0.0024 16.9 9.1 0.0024 16.9 9.1 3.2 2 1 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RskA PF10099.9 CDI79991.1 - 0.02 15.2 0.2 0.02 15.2 0.2 6.6 1 1 4 5 5 5 0 Anti-sigma-K factor rskA Connexin PF00029.19 CDI79991.1 - 0.22 11.3 23.4 0.32 10.7 0.4 3.3 3 0 0 3 3 3 0 Connexin FAM176 PF14851.6 CDI79991.1 - 1.1 8.9 30.8 0.26 10.9 0.7 3.8 4 0 0 4 4 4 0 FAM176 family TPR_2 PF07719.17 CDI79993.1 - 0.0015 18.5 11.6 0.61 10.3 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat SR-25 PF10500.9 CDI79993.1 - 0.0025 17.5 6.5 0.0025 17.5 6.5 3.9 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein TPR_16 PF13432.6 CDI79993.1 - 0.021 15.4 3.2 0.021 15.4 3.2 7.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TFIIA PF03153.13 CDI79993.1 - 0.055 13.5 34.1 0.24 11.3 22.8 3.3 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 CDI79993.1 - 0.15 10.7 14.4 1.2 7.8 0.4 2.3 2 0 0 2 2 2 0 Hamartin protein TPR_1 PF00515.28 CDI79993.1 - 0.26 11.2 3.3 2.3 8.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Coilin_N PF15862.5 CDI79993.1 - 0.32 10.8 0.0 0.32 10.8 0.0 3.8 4 0 0 4 4 4 0 Coilin N-terminus Presenilin PF01080.17 CDI79993.1 - 5.6 5.6 17.3 1.1 7.9 8.3 2.5 3 0 0 3 3 3 0 Presenilin SR-25 PF10500.9 CDI79994.1 - 2.3e-05 24.1 38.2 2.3e-05 24.1 38.2 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein PAT1 PF09770.9 CDI79994.1 - 0.0096 14.2 56.7 0.013 13.8 56.7 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF4776 PF16003.5 CDI79994.1 - 0.066 12.2 37.3 0.086 11.8 37.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Cadherin_C_2 PF16492.5 CDI79994.1 - 0.48 11.2 0.0 0.48 11.2 0.0 3.2 1 1 1 2 2 2 0 Cadherin cytoplasmic C-terminal PPP4R2 PF09184.11 CDI79994.1 - 0.81 9.2 30.4 1.1 8.8 30.4 1.2 1 0 0 1 1 1 0 PPP4R2 F-box-like PF12937.7 CDI79995.1 - 1.1e-07 31.6 1.1 2.6e-07 30.4 0.1 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CDI79995.1 - 0.002 18.0 0.1 0.002 18.0 0.1 2.5 3 0 0 3 3 3 1 F-box domain Choline_kinase PF01633.20 CDI79997.1 - 1.9e-21 76.7 1.5 4.3e-14 52.6 0.0 2.7 3 0 0 3 3 3 2 Choline/ethanolamine kinase APH PF01636.23 CDI79997.1 - 7.2e-08 32.7 3.4 0.0023 17.9 0.7 2.9 3 0 0 3 3 3 2 Phosphotransferase enzyme family TFIIA PF03153.13 CDI79997.1 - 0.00012 22.2 24.7 0.01 15.9 12.8 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 CDI79997.1 - 0.0064 16.9 6.4 0.064 13.7 0.7 2.6 2 0 0 2 2 2 1 Subunit CCDC53 of WASH complex Spt20 PF12090.8 CDI79997.1 - 0.0069 16.0 34.3 0.1 12.2 17.4 2.2 2 0 0 2 2 2 2 Spt20 family SPX PF03105.19 CDI79997.1 - 0.013 15.4 14.5 0.035 14.0 14.5 1.6 1 1 0 1 1 1 0 SPX domain Med15 PF09606.10 CDI79997.1 - 0.015 14.1 23.0 0.055 12.2 10.3 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3371 PF11851.8 CDI79997.1 - 0.016 16.3 7.1 0.016 16.3 7.1 3.5 3 1 0 3 3 1 0 Domain of unknown function (DUF3371) EcKinase PF02958.20 CDI79997.1 - 0.018 14.4 0.4 0.018 14.4 0.4 1.7 2 0 0 2 2 2 0 Ecdysteroid kinase DUF1266 PF06889.11 CDI79997.1 - 0.27 11.3 4.7 8.2 6.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) Tim54 PF11711.8 CDI79997.1 - 0.35 9.6 8.7 0.21 10.3 0.8 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Plasmodium_Vir PF05795.11 CDI79997.1 - 0.51 9.7 4.7 1.9 7.8 0.3 2.3 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Roughex PF06020.11 CDI79997.1 - 0.78 8.8 19.4 2.3 7.3 8.5 2.3 2 0 0 2 2 2 0 Drosophila roughex protein DUF5327 PF17261.2 CDI79997.1 - 0.93 10.3 19.7 1.6 9.5 3.6 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5327) FAM176 PF14851.6 CDI79997.1 - 1 9.0 12.4 1.1 8.9 2.3 2.4 2 0 0 2 2 2 0 FAM176 family CRF1 PF10380.9 CDI79997.1 - 1.1 9.6 6.4 4.1 7.8 0.3 2.7 2 0 0 2 2 2 0 Transcription factor CRF1 DUF913 PF06025.12 CDI79997.1 - 1.2 8.1 6.4 2.8 6.8 0.4 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) EPL1 PF10513.9 CDI79997.1 - 1.4 9.3 16.6 2 8.8 6.2 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like CPSF100_C PF13299.6 CDI79997.1 - 1.4 9.0 10.0 3.4 7.8 1.9 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal dsDNA_bind PF01984.20 CDI79997.1 - 2.9 8.2 25.8 7 7.0 10.3 2.6 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF4175 PF13779.6 CDI79997.1 - 3.2 5.6 27.4 2.6 5.9 7.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) DUF2115 PF09888.9 CDI79997.1 - 5 7.6 8.9 0.28 11.7 2.4 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) DUF4820 PF16091.5 CDI79997.1 - 5.7 6.2 10.3 2.9 7.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) MCU PF04678.13 CDI79997.1 - 6.1 6.9 8.5 7.8 6.6 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF4770 PF15994.5 CDI79997.1 - 6.4 7.0 11.9 3.4 7.9 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Pinin_SDK_memA PF04696.13 CDI79997.1 - 8.3 6.5 25.5 0.6 10.2 5.2 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region ORC_WH_C PF18137.1 CDI79997.1 - 8.5 6.5 9.1 19 5.3 1.6 2.4 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Kei1 PF08552.11 CDI79997.1 - 9.7 6.0 6.2 14 5.5 0.6 2.6 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF3752 PF12572.8 CDI79999.1 - 0.087 13.3 22.0 0.44 11.1 22.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3752) Actin PF00022.19 CDI80000.1 - 9.1e-69 232.0 0.0 1.5e-66 224.7 0.0 2.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDI80000.1 - 0.95 8.2 2.8 16 4.2 0.0 2.8 3 0 0 3 3 3 0 MreB/Mbl protein Dynamitin PF04912.14 CDI80001.1 - 8.9e-41 140.5 7.2 1.4e-36 126.7 7.2 2.2 1 1 0 1 1 1 1 Dynamitin DUF4094 PF13334.6 CDI80001.1 - 0.19 12.2 2.8 9.6 6.7 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) PCRF PF03462.18 CDI80001.1 - 0.19 11.6 5.3 0.097 12.5 0.4 2.7 3 0 0 3 3 3 0 PCRF domain Spectrin PF00435.21 CDI80001.1 - 0.92 10.0 9.1 3.5 8.2 0.8 2.8 2 0 0 2 2 2 0 Spectrin repeat TRAF_BIRC3_bd PF16673.5 CDI80001.1 - 4.3 7.2 7.7 0.93 9.3 0.5 3.0 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain CLZ PF16526.5 CDI80001.1 - 6.8 7.1 12.1 14 6.2 2.0 3.8 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels zf-C3HC4 PF00097.25 CDI80002.1 - 1e-06 28.5 8.4 1e-06 28.5 8.4 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDI80002.1 - 1e-05 25.6 11.4 2.4e-05 24.4 11.4 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CDI80002.1 - 1.8e-05 24.5 8.3 1.8e-05 24.5 8.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI80002.1 - 8.5e-05 22.5 6.4 0.00023 21.1 6.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDI80002.1 - 0.00029 20.6 7.6 0.00029 20.6 7.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI80002.1 - 0.00087 19.6 9.4 0.0018 18.6 9.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CDI80002.1 - 0.00099 19.0 8.8 0.0059 16.5 9.2 2.1 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 CDI80002.1 - 0.001 18.9 3.5 0.0021 17.9 3.5 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 CDI80002.1 - 0.0041 16.9 3.6 0.008 16.0 3.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 CDI80002.1 - 0.11 12.5 2.9 0.23 11.5 2.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CDI80002.1 - 0.12 12.3 7.5 3 7.8 8.2 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-H2C2_2 PF13465.6 CDI80002.1 - 0.79 10.3 5.0 2.4 8.8 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger double domain Rad50_zn_hook PF04423.14 CDI80002.1 - 1.4 8.8 10.7 0.71 9.8 0.9 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RING_4 PF14570.6 CDI80002.1 - 2.1 8.2 13.8 16 5.4 14.1 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF3275 PF11679.8 CDI80005.1 - 1.3 9.0 4.4 1.4 8.8 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) zf-RING_4 PF14570.6 CDI80006.1 - 1.2e-19 69.9 10.6 2.1e-19 69.0 10.6 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 CDI80006.1 - 1.3e-06 28.1 0.0 2.5e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 CDI80006.1 - 3.4e-06 26.8 9.0 3.4e-06 26.8 9.0 1.9 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Torus PF16131.5 CDI80006.1 - 0.0047 17.6 0.1 0.0047 17.6 0.1 3.6 3 1 0 3 3 3 1 Torus domain zf-RING_2 PF13639.6 CDI80006.1 - 0.011 16.1 11.4 0.011 16.1 11.4 1.9 2 0 0 2 2 2 0 Ring finger domain Baculo_IE-1 PF05290.11 CDI80006.1 - 0.17 11.8 3.3 0.33 10.9 3.3 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 CDI80006.1 - 0.46 10.4 11.1 1.8 8.5 4.5 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-UDP PF14569.6 CDI80006.1 - 0.57 10.3 3.1 1.4 9.1 3.1 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Rad50_zn_hook PF04423.14 CDI80006.1 - 2.8 7.9 9.4 2.3 8.1 2.4 3.1 3 0 0 3 3 3 0 Rad50 zinc hook motif DZR PF12773.7 CDI80006.1 - 3.1 7.9 9.6 12 6.0 9.6 2.0 1 0 0 1 1 1 0 Double zinc ribbon Radical_SAM PF04055.21 CDI80007.1 - 1.2e-17 64.8 0.0 4e-17 63.1 0.0 2.0 3 0 0 3 3 3 1 Radical SAM superfamily UPF0004 PF00919.20 CDI80007.1 - 2.5e-11 43.5 2.3 1.4e-05 25.0 0.4 3.5 2 1 1 3 3 3 2 Uncharacterized protein family UPF0004 Spt20 PF12090.8 CDI80007.1 - 2.5 7.7 8.9 4.7 6.7 8.9 1.4 1 0 0 1 1 1 0 Spt20 family dsDNA_bind PF01984.20 CDI80007.1 - 7.5 6.9 15.6 11 6.4 3.1 2.4 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Neur_chan_memb PF02932.16 CDI80008.1 - 6.3 6.8 7.2 6.9 6.7 0.8 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI80009.1 - 0.98 7.7 6.7 1.8 6.9 6.7 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EOS1 PF12326.8 CDI80009.1 - 1 9.2 7.2 0.94 9.4 3.7 2.5 2 0 0 2 2 2 0 N-glycosylation protein HCO3_cotransp PF00955.21 CDI80009.1 - 5.5 5.7 9.9 12 4.6 9.9 1.5 1 0 0 1 1 1 0 HCO3- transporter family Cellulose_synt PF03552.14 CDI80009.1 - 8.3 4.8 6.7 12 4.2 6.7 1.2 1 0 0 1 1 1 0 Cellulose synthase AAA_lid_9 PF17871.1 CDI80010.1 - 2.4e-31 107.7 0.8 2.4e-31 107.7 0.8 3.7 2 1 3 5 5 5 1 AAA lid domain ClpB_D2-small PF10431.9 CDI80010.1 - 3.4e-25 87.9 2.0 1.9e-24 85.5 2.0 2.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.20 CDI80010.1 - 1e-21 76.8 2.8 8.4e-13 48.2 0.1 2.8 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA PF00004.29 CDI80010.1 - 9.2e-13 48.8 0.0 1.9e-05 25.1 0.1 3.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI80010.1 - 1.2e-11 45.3 12.2 1.7e-06 28.5 0.1 4.0 5 1 0 5 5 2 2 AAA ATPase domain AAA_2 PF07724.14 CDI80010.1 - 4.7e-09 36.6 0.7 0.0055 16.8 0.0 4.1 2 2 2 4 4 4 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CDI80010.1 - 2.8e-08 33.8 1.3 0.023 14.7 0.0 4.4 3 1 1 4 4 3 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI80010.1 - 4.2e-08 33.8 1.3 0.00051 20.6 0.0 3.6 3 1 0 3 3 2 2 AAA domain TniB PF05621.11 CDI80010.1 - 4.2e-07 29.5 0.1 0.058 12.8 0.0 4.2 3 1 1 4 4 4 2 Bacterial TniB protein IstB_IS21 PF01695.17 CDI80010.1 - 5.2e-07 29.6 0.1 0.13 12.0 0.0 3.8 4 0 0 4 4 3 2 IstB-like ATP binding protein ATPase_2 PF01637.18 CDI80010.1 - 3.1e-06 27.3 0.7 0.51 10.2 0.0 3.9 2 1 2 4 4 4 2 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CDI80010.1 - 4e-06 27.1 1.6 0.092 13.0 0.0 4.1 2 1 1 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 CDI80010.1 - 1.6e-05 24.9 0.2 1.1 9.1 0.0 3.7 3 0 0 3 3 3 2 RsgA GTPase RuvB_N PF05496.12 CDI80010.1 - 1.8e-05 24.6 0.3 0.36 10.6 0.0 3.6 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 CDI80010.1 - 2.1e-05 24.5 0.0 0.63 10.1 0.0 3.3 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDI80010.1 - 3e-05 24.0 0.0 0.45 10.4 0.0 3.6 3 0 0 3 3 3 2 NACHT domain Roc PF08477.13 CDI80010.1 - 6.1e-05 23.2 0.0 0.56 10.4 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 CDI80010.1 - 9e-05 22.8 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Bac_DnaA PF00308.18 CDI80010.1 - 0.0011 18.9 0.0 0.057 13.2 0.0 2.6 2 0 0 2 2 2 1 Bacterial dnaA protein Torsin PF06309.11 CDI80010.1 - 0.0013 18.9 0.0 0.0034 17.5 0.0 1.7 1 0 0 1 1 1 1 Torsin AAA_14 PF13173.6 CDI80010.1 - 0.0015 18.6 0.0 3.5 7.7 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDI80010.1 - 0.0024 18.2 1.1 2.3 8.6 0.1 3.2 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 CDI80010.1 - 0.0029 17.1 0.0 1.6 8.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 CDI80010.1 - 0.0032 17.6 0.5 3.7 7.7 0.0 4.0 4 0 0 4 4 3 1 AAA domain ResIII PF04851.15 CDI80010.1 - 0.0039 17.2 0.0 0.2 11.6 0.0 3.0 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 CDI80010.1 - 0.0042 17.0 1.1 4 7.3 0.0 3.2 3 0 0 3 3 3 1 NTPase DUF815 PF05673.13 CDI80010.1 - 0.015 14.5 0.0 0.38 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 CDI80010.1 - 0.016 14.6 0.0 6.2 6.2 0.0 2.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 CDI80010.1 - 0.017 14.7 0.3 4.2 6.9 0.0 3.0 2 1 1 3 3 3 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 CDI80010.1 - 0.026 15.0 0.0 1.3 9.6 0.0 2.8 2 0 0 2 2 2 0 ABC transporter PduV-EutP PF10662.9 CDI80010.1 - 0.026 14.2 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 CDI80010.1 - 0.029 14.2 0.0 0.89 9.3 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 CDI80010.1 - 0.11 12.6 0.0 25 5.0 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase ABC_tran_CTD PF16326.5 CDI80010.1 - 0.12 12.6 9.5 0.053 13.8 3.6 3.4 1 1 1 2 2 2 0 ABC transporter C-terminal domain AAA_24 PF13479.6 CDI80010.1 - 0.14 11.9 0.1 19 4.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 CDI80010.1 - 0.2 11.9 6.2 4 7.7 0.0 4.0 5 0 0 5 5 3 0 AAA domain LUC7 PF03194.15 CDI80010.1 - 2.5 7.7 5.3 1.4 8.5 2.9 1.7 2 0 0 2 2 1 0 LUC7 N_terminus Lactamase_B_2 PF12706.7 CDI80011.1 - 2.9e-14 53.1 0.0 2.3e-09 37.1 0.0 2.6 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDI80011.1 - 5.9e-07 29.7 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF4207 PF13904.6 CDI80011.1 - 0.00058 19.6 8.2 0.0011 18.7 8.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Lactamase_B_6 PF16661.5 CDI80011.1 - 0.063 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain SUIM_assoc PF16619.5 CDI80011.1 - 0.18 11.9 14.3 0.49 10.5 14.3 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI80011.1 - 0.47 10.0 18.7 0.9 9.1 18.7 1.4 1 0 0 1 1 1 0 Spt20 family ABC_tran_Xtn PF12848.7 CDI80011.1 - 0.95 9.5 13.5 0.19 11.8 8.8 2.2 2 0 0 2 2 2 0 ABC transporter Presenilin PF01080.17 CDI80011.1 - 6.8 5.3 6.3 11 4.6 6.3 1.3 1 0 0 1 1 1 0 Presenilin PikAIV_N PF18605.1 CDI80012.1 - 4.5 6.9 12.2 0.65 9.6 7.2 2.2 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain WD40 PF00400.32 CDI80013.1 - 3.1e-23 81.6 8.6 0.0018 19.0 0.0 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI80013.1 - 1.9e-08 34.5 0.3 0.085 13.2 0.0 4.5 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PRTP PF01366.18 CDI80015.1 - 9.1 4.2 19.0 0.087 10.9 9.8 1.8 1 1 1 2 2 2 0 Herpesvirus processing and transport protein MFS_1 PF07690.16 CDI80018.1 - 0.0012 17.9 29.6 0.0012 17.9 29.6 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily OATP PF03137.20 CDI80018.1 - 0.002 16.5 0.1 0.002 16.5 0.1 5.1 4 2 1 5 5 5 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CDI80018.1 - 0.0044 15.9 0.9 0.0072 15.2 0.9 1.2 1 0 0 1 1 1 1 MFS_1 like family TFIIA PF03153.13 CDI80018.1 - 0.0078 16.3 15.3 0.0078 16.3 15.3 4.3 3 1 1 4 4 4 2 Transcription factor IIA, alpha/beta subunit SOBP PF15279.6 CDI80018.1 - 4.9 7.7 55.8 1.9 9.0 7.3 3.4 3 0 0 3 3 3 0 Sine oculis-binding protein RskA PF10099.9 CDI80019.1 - 2.5e-05 24.6 11.3 2.5e-05 24.6 11.3 6.6 2 2 3 5 5 5 3 Anti-sigma-K factor rskA PI3K_1B_p101 PF10486.9 CDI80019.1 - 0.0011 16.9 5.1 0.0011 16.9 5.1 3.0 2 1 0 3 3 3 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4179 PF13786.6 CDI80019.1 - 1.2 9.7 0.0 1.2 9.7 0.0 5.4 5 1 0 5 5 5 0 Domain of unknown function (DUF4179) MID_MedPIWI PF18296.1 CDI80020.1 - 0.15 11.8 3.0 0.2 11.4 3.0 1.1 1 0 0 1 1 1 0 MID domain of medPIWI TRAP_alpha PF03896.16 CDI80020.1 - 0.15 11.2 0.4 0.23 10.6 0.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4834 PF16118.5 CDI80020.1 - 0.82 10.7 3.9 8.8 7.4 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) NAM-associated PF14303.6 CDI80020.1 - 2.2 9.0 8.1 3 8.5 8.1 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF3138 PF11336.8 CDI80020.1 - 3.1 6.3 17.2 3.9 6.0 17.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Presenilin PF01080.17 CDI80020.1 - 3.1 6.5 5.5 3.6 6.3 5.5 1.1 1 0 0 1 1 1 0 Presenilin Rsm22 PF09243.10 CDI80021.1 - 5.4e-27 94.7 0.0 3.5e-16 59.3 0.0 2.4 1 1 1 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 Androgen_recep PF02166.16 CDI80024.1 - 0.0016 17.4 8.3 0.0016 17.4 8.3 11.3 9 2 2 11 11 11 2 Androgen receptor Phage_TAC_7 PF10109.9 CDI80026.1 - 0.057 13.5 0.1 0.44 10.7 0.1 2.6 1 1 1 2 2 2 0 Phage tail assembly chaperone proteins, E, or 41 or 14 TFIIA PF03153.13 CDI80026.1 - 2.5 8.0 38.3 0.04 13.9 29.3 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TFIIA PF03153.13 CDI80027.1 - 3.6e-05 23.9 14.7 3.6e-05 23.9 14.7 7.9 2 2 3 6 6 6 1 Transcription factor IIA, alpha/beta subunit Stealth_CR4 PF17103.5 CDI80027.1 - 0.009 15.9 0.1 0.027 14.3 0.1 1.8 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 Cpn60_TCP1 PF00118.24 CDI80028.1 - 2.5e-78 263.9 14.8 4.8e-36 124.4 4.3 3.3 1 1 2 3 3 3 3 TCP-1/cpn60 chaperonin family Caudo_TAP PF02413.17 CDI80028.1 - 0.17 12.1 2.0 0.4 10.8 2.0 1.6 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Bax1-I PF01027.20 CDI80029.1 - 3.5e-05 23.7 0.1 3.8e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Pkinase PF00069.25 CDI80036.1 - 8.3e-58 195.8 0.0 1e-57 195.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80036.1 - 1.5e-33 116.2 0.0 2.9e-33 115.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDI80036.1 - 5.9e-05 23.1 0.0 0.13 12.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDI80036.1 - 0.00029 19.8 0.0 0.00045 19.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDI80036.1 - 0.00036 20.0 0.0 0.002 17.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDI80036.1 - 0.033 13.6 0.1 0.084 12.2 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_S8e PF01201.22 CDI80037.1 - 3.7e-49 166.4 7.2 5.9e-49 165.8 7.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e CCDC-167 PF15188.6 CDI80037.1 - 9.2 6.7 9.8 2.7 8.4 5.3 2.2 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Bep_C_terminal PF17841.1 CDI80038.1 - 0.32 11.2 3.1 5.5 7.3 0.0 2.9 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) Fungal_TACC PF12709.7 CDI80038.1 - 1.7 9.1 4.9 0.81 10.2 0.5 2.8 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Cyclin_N PF00134.23 CDI80039.1 - 1e-10 41.4 0.5 2.6e-10 40.1 0.2 1.8 1 1 1 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDI80039.1 - 0.00034 20.7 0.0 0.0075 16.3 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain BRCT_2 PF16589.5 CDI80041.1 - 3.4e-08 33.8 0.0 1.1e-07 32.1 0.0 2.0 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CDI80041.1 - 0.019 15.3 0.0 0.076 13.4 0.0 2.1 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Med21 PF11221.8 CDI80044.1 - 8 6.7 0.0 8 6.7 0.0 3.1 2 1 0 2 2 2 0 Subunit 21 of Mediator complex TraC PF07820.12 CDI80045.1 - 2 8.8 0.0 2 8.8 0.0 5.0 4 2 1 5 5 5 0 TraC-like protein DB PF01682.19 CDI80046.1 - 1.1 9.5 6.6 0.3 11.4 3.1 1.8 2 0 0 2 2 2 0 DB module SR-25 PF10500.9 CDI80046.1 - 1.7 8.2 8.4 1.1 8.8 4.0 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Dehydrin PF00257.19 CDI80046.1 - 2.2 8.8 11.1 2.4 8.7 2.2 2.3 2 0 0 2 2 2 0 Dehydrin RRP7 PF12923.7 CDI80047.1 - 0.0013 18.9 0.4 0.0022 18.1 0.4 1.4 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 CDI80047.1 - 0.072 12.9 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CDI80047.1 - 0.16 11.8 0.2 0.34 10.7 0.0 1.6 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain LTV PF04180.14 CDI80048.1 - 0.04 13.6 32.7 0.065 13.0 32.7 1.2 1 0 0 1 1 1 0 Low temperature viability protein CDC45 PF02724.14 CDI80048.1 - 0.18 10.1 38.0 0.25 9.6 38.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Dapper PF15268.6 CDI80048.1 - 1.3 7.8 51.2 1.6 7.5 51.2 1.0 1 0 0 1 1 1 0 Dapper DUF4045 PF13254.6 CDI80048.1 - 3.3 7.3 40.3 5.6 6.5 40.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) PP2C PF00481.21 CDI80051.1 - 3.5e-28 99.0 0.0 1e-26 94.1 0.0 2.3 2 0 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI80051.1 - 0.0064 16.4 0.0 0.021 14.8 0.0 1.8 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PseudoU_synth_1 PF01416.20 CDI80052.1 - 1.9e-12 47.6 0.7 9.9e-09 35.6 0.0 3.9 2 1 1 3 3 3 2 tRNA pseudouridine synthase SR-25 PF10500.9 CDI80052.1 - 0.0025 17.5 11.0 0.0025 17.5 11.0 5.0 5 0 0 5 5 5 2 Nuclear RNA-splicing-associated protein SID-1_RNA_chan PF13965.6 CDI80053.1 - 0.0011 17.5 2.7 0.0011 17.5 2.7 2.4 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 SAPS PF04499.15 CDI80053.1 - 0.0019 17.0 9.9 0.0019 17.0 9.9 3.4 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein Rgp1 PF08737.10 CDI80053.1 - 0.002 17.4 3.1 0.002 17.4 3.1 5.1 2 2 2 4 4 4 1 Rgp1 RskA PF10099.9 CDI80053.1 - 0.003 17.9 2.0 0.003 17.9 2.0 9.4 2 2 4 6 6 6 1 Anti-sigma-K factor rskA DUF420 PF04238.12 CDI80053.1 - 0.11 12.8 0.1 0.22 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF420) NIF PF03031.18 CDI80054.1 - 2.5e-24 85.8 0.0 7.6e-22 77.8 0.0 3.4 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase Collagen PF01391.18 CDI80054.1 - 1.3e-08 34.4 34.2 0.00044 20.0 34.2 3.5 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) RskA PF10099.9 CDI80054.1 - 0.0082 16.5 6.8 0.0082 16.5 6.8 12.7 6 3 4 10 10 10 3 Anti-sigma-K factor rskA HAD PF12710.7 CDI80054.1 - 0.024 15.1 0.4 0.11 12.9 0.4 2.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase INCENP_ARK-bind PF03941.15 CDI80055.1 - 7.3e-07 29.0 0.1 7.3e-07 29.0 0.1 3.0 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region SR-25 PF10500.9 CDI80055.1 - 0.0028 17.3 8.5 0.0028 17.3 8.5 8.2 5 2 0 6 6 6 1 Nuclear RNA-splicing-associated protein TMEM51 PF15345.6 CDI80055.1 - 0.006 16.5 3.7 0.006 16.5 3.7 4.3 5 1 0 5 5 5 1 Transmembrane protein 51 PCNA_N PF00705.18 CDI80056.1 - 2.9e-45 153.1 4.9 1.4e-44 150.8 2.5 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 CDI80056.1 - 2.2e-28 99.0 0.0 1.5e-27 96.3 0.0 2.2 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 CDI80056.1 - 4.5e-07 29.6 0.8 0.00044 19.8 0.1 2.2 1 1 0 2 2 2 2 Rad9 X PF00739.19 CDI80057.1 - 0.013 15.6 0.6 0.013 15.6 0.6 2.9 2 0 0 2 2 2 0 Trans-activation protein X Caldesmon PF02029.15 CDI80057.1 - 0.33 9.7 52.9 0.11 11.3 49.3 1.8 2 0 0 2 2 2 0 Caldesmon PAT1 PF09770.9 CDI80057.1 - 1.6 6.9 93.7 1.1 7.4 26.3 2.7 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Exonuc_VII_L PF02601.15 CDI80057.1 - 5.6 6.4 57.2 2 7.9 37.4 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit AAA_lid_3 PF17862.1 CDI80058.1 - 1.2e-17 63.4 1.8 4.8e-10 39.1 0.1 2.9 2 1 0 2 2 2 2 AAA+ lid domain AAA PF00004.29 CDI80058.1 - 8.4e-12 45.7 0.1 3.1e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDI80058.1 - 0.0021 18.0 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain K_channel_TID PF07941.11 CDI80058.1 - 0.041 14.3 16.0 0.041 14.3 16.0 2.0 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain STPPase_N PF16891.5 CDI80058.1 - 0.17 12.3 1.3 2.6 8.5 0.3 2.4 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain APG9 PF04109.16 CDI80059.1 - 1.7e-09 37.2 0.0 3.8e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Autophagy protein Apg9 RCR PF12273.8 CDI80059.1 - 0.061 14.0 0.0 0.061 14.0 0.0 5.8 4 1 0 4 4 4 0 Chitin synthesis regulation, resistance to Congo red CAF1 PF04857.20 CDI80060.1 - 1.4e-24 86.8 0.1 8.4e-14 51.4 0.0 2.3 1 1 1 2 2 2 2 CAF1 family ribonuclease SUIM_assoc PF16619.5 CDI80060.1 - 0.031 14.3 1.3 23 5.1 1.7 3.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Arm PF00514.23 CDI80061.1 - 3.2e-09 36.5 0.0 0.00031 20.7 0.0 3.1 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HutP PF09021.11 CDI80061.1 - 0.086 13.2 0.0 0.17 12.2 0.0 1.4 1 1 0 1 1 1 0 HutP DSPc PF00782.20 CDI80062.1 - 2.1e-06 27.6 0.3 9e-06 25.5 0.3 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CAC1F_C PF16885.5 CDI80062.1 - 0.011 15.5 1.3 0.011 15.5 1.3 5.6 5 2 1 6 6 6 0 Voltage-gated calcium channel subunit alpha, C-term Y_phosphatase3 PF13350.6 CDI80062.1 - 0.019 15.0 0.1 0.019 15.0 0.1 3.4 4 0 0 4 4 4 0 Tyrosine phosphatase family ACDC PF14733.6 CDI80063.1 - 1.1e-17 64.0 0.0 4.7e-17 62.1 0.0 2.1 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 CDI80063.1 - 3.2e-05 24.1 2.9 0.00016 21.8 2.9 2.4 1 0 0 1 1 1 1 AP2 domain RRM_1 PF00076.22 CDI80065.1 - 1.3e-16 60.1 0.2 6.3e-08 32.3 0.0 4.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI80065.1 - 0.017 15.0 0.0 4.8 7.1 0.0 2.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif BRAP2 PF07576.12 CDI80065.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 BRCA1-associated protein 2 DUF1373 PF07117.11 CDI80065.1 - 1.8 8.5 9.7 3.7 7.5 9.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1373) DnaJ-X PF14308.6 CDI80066.1 - 1.2e-53 181.8 4.8 1.2e-53 181.8 4.8 1.8 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 CDI80066.1 - 4.9e-28 97.0 2.4 1e-27 96.1 2.4 1.6 1 0 0 1 1 1 1 DnaJ domain Methyltransf_25 PF13649.6 CDI80066.1 - 0.34 11.6 3.6 7.7 7.3 0.1 2.8 2 1 1 3 3 3 0 Methyltransferase domain Med3 PF11593.8 CDI80066.1 - 4.8 6.3 28.0 0.34 10.1 11.9 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Herpes_UL52 PF03121.15 CDI80070.1 - 0.00021 21.1 0.0 0.00074 19.4 0.0 1.9 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase SPX PF03105.19 CDI80070.1 - 0.00028 20.9 5.1 0.00028 20.9 5.1 5.5 3 2 0 3 3 3 1 SPX domain Claudin_2 PF13903.6 CDI80071.1 - 0.74 9.5 8.6 4.2 7.1 0.4 2.9 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction T_Ag_DNA_bind PF02217.16 CDI80073.1 - 4.5 8.0 4.8 1.8 9.2 1.1 2.3 2 1 0 2 2 2 0 Origin of replication binding protein zf-HIT PF04438.16 CDI80074.1 - 1.2e-07 31.4 11.5 3e-07 30.2 11.5 1.6 1 0 0 1 1 1 1 HIT zinc finger Zip PF02535.22 CDI80074.1 - 0.028 13.7 1.0 0.045 13.0 1.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 CDI80074.1 - 0.069 12.5 14.6 0.13 11.6 14.6 1.4 1 0 0 1 1 1 0 NOA36 protein PIP5K PF01504.18 CDI80074.1 - 6.8 5.8 10.5 1.3 8.2 6.1 1.9 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Hid1 PF12722.7 CDI80074.1 - 9.2 4.2 20.5 0.2 9.7 11.7 1.9 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 CDI80074.1 - 9.7 4.3 20.6 0.028 12.7 11.1 1.5 2 0 0 2 2 2 0 CDC45-like protein DUF1635 PF07795.11 CDI80074.1 - 10 5.9 31.8 2.4 8.0 3.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1635) ubiquitin PF00240.23 CDI80075.1 - 2.4e-07 30.4 13.2 3.4e-07 29.9 0.0 4.3 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CDI80075.1 - 2.7e-07 30.7 0.1 2.7e-07 30.7 0.1 5.5 4 2 1 5 5 5 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 CDI80075.1 - 5e-05 23.1 4.1 0.00061 19.6 0.0 3.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 CDI80075.1 - 0.00039 21.0 0.1 0.0019 18.8 0.1 2.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD DUF2407 PF10302.9 CDI80075.1 - 0.033 14.8 0.8 0.033 14.8 0.8 6.1 4 2 0 4 4 4 0 DUF2407 ubiquitin-like domain DUF1378 PF07125.11 CDI80075.1 - 0.45 10.7 2.0 2.5 8.3 2.0 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1378) RAP1 PF07218.11 CDI80075.1 - 3.4 5.8 3.9 4.9 5.3 3.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Phage_sheath_1 PF04984.14 CDI80079.1 - 0.51 10.2 0.0 0.51 10.2 0.0 3.8 3 0 0 3 3 3 0 Phage tail sheath protein subtilisin-like domain Coilin_N PF15862.5 CDI80079.1 - 0.84 9.4 0.0 0.84 9.4 0.0 11.7 6 3 4 11 11 11 0 Coilin N-terminus CPSase_L_D2 PF02786.17 CDI80080.1 - 3.4e-50 170.5 0.0 7.5e-50 169.4 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDI80080.1 - 3.1e-28 98.5 0.0 9.2e-28 97.0 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Carboxyl_trans PF01039.22 CDI80080.1 - 5.6e-28 97.8 4.1 1.5e-19 70.0 2.7 3.5 1 1 1 2 2 2 2 Carboxyl transferase domain Biotin_carb_C PF02785.19 CDI80080.1 - 2.4e-20 72.6 0.0 5.4e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDI80080.1 - 3.5e-12 46.0 0.0 9.2e-12 44.6 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 CDI80080.1 - 6e-09 35.7 0.0 1e-07 31.7 0.0 3.0 2 0 0 2 2 2 1 ATP-grasp domain ACC_central PF08326.12 CDI80080.1 - 1.2e-08 33.7 3.4 1.2e-08 33.7 3.4 4.0 4 1 0 5 5 5 3 Acetyl-CoA carboxylase, central region Dala_Dala_lig_C PF07478.13 CDI80080.1 - 1.9e-05 24.3 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus SpoIIP PF07454.11 CDI80080.1 - 0.65 9.4 30.9 0.37 10.2 4.6 3.4 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Chorein_N PF12624.7 CDI80082.1 - 3.3e-29 101.3 0.1 3.3e-29 101.3 0.1 5.2 5 0 0 5 5 5 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 CDI80082.1 - 7.2e-17 62.0 3.1 7.7e-15 55.3 0.0 4.1 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal FAM91_C PF14648.6 CDI80082.1 - 0.64 8.8 7.8 1.5 7.6 1.6 2.8 2 0 0 2 2 2 0 FAM91 C-terminus Ribosomal_L11_N PF03946.14 CDI80083.1 - 2.4e-21 75.3 0.1 3.5e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDI80083.1 - 1.5e-17 63.9 0.2 2.4e-17 63.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain gerPA PF10676.9 CDI80083.1 - 0.087 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF Ribosomal_L30 PF00327.20 CDI80084.1 - 2e-14 53.2 0.7 3.7e-14 52.3 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CDI80084.1 - 9.4e-14 51.4 15.9 9.4e-14 51.4 15.9 1.7 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_S8e PF01201.22 CDI80084.1 - 0.011 15.9 1.2 0.015 15.5 1.2 1.2 1 0 0 1 1 1 0 Ribosomal protein S8e Steroid_dh PF02544.16 CDI80085.1 - 1.2e-08 35.0 0.1 6.2e-06 26.3 0.0 3.3 3 0 0 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase Shisa PF13908.6 CDI80085.1 - 0.025 14.8 4.0 0.5 10.6 0.9 2.4 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator SR-25 PF10500.9 CDI80085.1 - 3.2 7.3 10.2 0.16 11.6 4.6 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI80085.1 - 4.9 7.0 9.9 9.3 6.1 9.9 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DTC PF18102.1 CDI80087.1 - 8.1e-15 55.1 0.0 2.3e-10 40.7 0.0 2.3 1 1 1 2 2 2 2 Deltex C-terminal domain WWE PF02825.20 CDI80087.1 - 1.1e-07 32.3 4.7 2.4e-06 28.0 3.0 3.1 2 1 0 2 2 2 1 WWE domain zf-RING_11 PF17123.5 CDI80087.1 - 0.059 13.1 5.6 3.5 7.5 0.1 2.5 2 0 0 2 2 2 0 RING-like zinc finger DAG_kinase_N PF14513.6 CDI80087.1 - 0.22 11.7 4.6 0.28 11.4 1.1 2.3 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Ribosomal_S19e PF01090.19 CDI80088.1 - 9.2e-51 171.2 0.0 1e-50 171.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.10 CDI80088.1 - 0.00083 19.2 0.1 0.0018 18.2 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain MarR_2 PF12802.7 CDI80088.1 - 0.17 11.8 0.1 0.54 10.2 0.0 1.8 2 0 0 2 2 2 0 MarR family AP_endonuc_2 PF01261.24 CDI80089.1 - 2.6e-31 108.7 0.0 4e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF2124 PF09897.9 CDI80089.1 - 0.16 11.8 0.1 0.45 10.4 0.1 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2124) RskA PF10099.9 CDI80090.1 - 0.007 16.7 8.2 0.007 16.7 8.2 5.0 3 2 0 3 3 3 2 Anti-sigma-K factor rskA TBSV_P22 PF03558.13 CDI80090.1 - 0.085 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 TBSV core protein P21/P22 Hydrolase PF00702.26 CDI80090.1 - 0.27 11.5 15.2 2 8.7 15.2 2.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI80091.1 - 9.9e-15 54.5 0.0 9.6e-14 51.3 0.0 2.3 1 1 1 2 2 2 1 E1-E2 ATPase DUF4834 PF16118.5 CDI80091.1 - 0.00024 22.0 22.6 0.06 14.3 0.3 4.2 4 0 0 4 4 4 2 Domain of unknown function (DUF4834) ResB PF05140.14 CDI80091.1 - 0.001 17.9 2.2 0.0063 15.3 0.3 2.7 3 0 0 3 3 3 1 ResB-like family FAM176 PF14851.6 CDI80091.1 - 0.0017 18.0 11.2 0.12 12.0 0.0 3.7 4 0 0 4 4 4 2 FAM176 family Cation_ATPase_N PF00690.26 CDI80091.1 - 0.0028 17.3 0.0 0.015 15.0 0.0 2.3 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus GRP PF07172.11 CDI80091.1 - 0.0093 16.6 2.9 1.9 9.3 0.0 3.3 3 0 0 3 3 3 1 Glycine rich protein family SHR3_chaperone PF08229.11 CDI80091.1 - 0.07 12.1 0.2 0.07 12.1 0.2 3.7 4 0 0 4 4 3 0 ER membrane protein SH3 DUF5531 PF17671.1 CDI80091.1 - 0.21 11.4 0.1 0.21 11.4 0.1 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5531) MLANA PF14991.6 CDI80091.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.2 4 0 0 4 4 4 0 Protein melan-A DUF2681 PF10883.8 CDI80091.1 - 6 7.3 51.8 0.062 13.7 4.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2681) DUF4079 PF13301.6 CDI80091.1 - 6.1 7.0 6.8 1.5 8.9 0.0 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF4079) OATP PF03137.20 CDI80091.1 - 8.2 4.6 5.7 8.2 4.6 0.3 2.6 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 CDI80091.1 - 9.9 4.8 18.5 0.97 8.1 4.7 2.9 3 0 0 3 3 3 0 Presenilin Connexin PF00029.19 CDI80091.1 - 10 5.8 12.2 2.4 7.8 0.0 3.6 4 0 0 4 4 4 0 Connexin DUF4778 PF16008.5 CDI80092.1 - 0.035 14.2 6.3 0.044 13.9 6.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Trp_oprn_chp PF09534.10 CDI80092.1 - 0.045 13.6 4.7 0.11 12.3 4.7 1.7 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CDH1_2_SANT_HL1 PF18375.1 CDI80092.1 - 0.089 13.5 1.8 0.3 11.8 0.1 2.1 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Ndc1_Nup PF09531.10 CDI80092.1 - 0.13 10.9 9.4 0.15 10.7 9.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 CDI80092.1 - 0.21 11.5 24.9 0.28 11.2 24.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI80092.1 - 0.31 9.8 9.9 0.37 9.5 9.9 1.1 1 0 0 1 1 1 0 Presenilin Neurokinin_B PF03823.14 CDI80092.1 - 0.91 9.6 0.1 0.91 9.6 0.1 3.1 3 1 0 3 3 2 0 Neurokinin B DUF5308 PF17233.2 CDI80092.1 - 1.4 9.1 15.7 0.15 12.2 3.9 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5308) PAT1 PF09770.9 CDI80092.1 - 1.4 7.0 19.1 1.6 6.9 19.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAT1 PF06391.13 CDI80092.1 - 1.9 8.3 11.2 2.5 7.9 11.2 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 V_ATPase_I PF01496.19 CDI80092.1 - 2.2 6.1 5.2 2.6 5.9 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 CDI80092.1 - 2.8 7.9 5.5 3.7 7.6 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDFI PF15316.6 CDI80092.1 - 4.7 7.3 10.3 6.3 6.9 10.3 1.1 1 0 0 1 1 1 0 MyoD family inhibitor Hid1 PF12722.7 CDI80092.1 - 5.3 5.0 6.6 6 4.9 6.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4407 PF14362.6 CDI80092.1 - 5.6 6.2 10.0 7.6 5.8 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PSCyt3 PF07627.11 CDI80092.1 - 8 6.8 11.1 3.2 8.1 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) Conotoxin PF02950.17 CDI80092.1 - 8.8 7.4 10.1 21 6.2 2.6 2.2 2 0 0 2 2 2 0 Conotoxin Methyltransf_16 PF10294.9 CDI80098.1 - 2.5e-09 37.1 0.0 0.17 11.6 0.1 4.2 4 0 0 4 4 4 4 Lysine methyltransferase PT PF04886.12 CDI80098.1 - 0.0035 16.8 6.7 0.0035 16.8 6.7 7.1 5 3 1 6 6 6 2 PT repeat Pkinase PF00069.25 CDI80099.1 - 2.1e-14 53.5 0.1 4.1e-12 46.0 0.0 4.5 4 1 0 4 4 4 2 Protein kinase domain RRM_1 PF00076.22 CDI80100.1 - 4.7e-06 26.3 0.0 1.7e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spt20 PF12090.8 CDI80100.1 - 0.013 15.1 9.0 0.019 14.6 9.0 1.2 1 0 0 1 1 1 0 Spt20 family DUF4179 PF13786.6 CDI80100.1 - 0.43 11.1 0.1 0.43 11.1 0.1 4.1 4 1 1 5 5 5 0 Domain of unknown function (DUF4179) Activator_LAG-3 PF11498.8 CDI80100.1 - 1 8.3 19.7 1.6 7.6 19.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 T2SSM PF04612.12 CDI80101.1 - 0.008 16.2 4.9 0.008 16.2 4.9 1.6 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein M DUF4228 PF14009.6 CDI80101.1 - 0.015 15.7 0.2 0.019 15.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) IHABP4_N PF16174.5 CDI80101.1 - 0.046 14.3 1.7 0.062 13.9 1.7 1.1 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal TFIIA PF03153.13 CDI80101.1 - 0.18 11.7 5.2 0.22 11.5 5.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI80101.1 - 0.29 11.4 12.7 0.55 10.5 12.7 1.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Adeno_PV PF03910.13 CDI80101.1 - 1.1 8.0 4.9 1.1 7.8 4.9 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Anophelin PF10731.9 CDI80101.1 - 4.9 7.1 6.2 0.88 9.5 0.9 2.0 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito Helicase_C PF00271.31 CDI80102.1 - 1e-16 61.3 0.0 1e-16 61.3 0.0 3.7 4 0 0 4 4 4 1 Helicase conserved C-terminal domain PEHE PF15275.6 CDI80104.1 - 0.064 13.9 0.2 0.064 13.9 0.2 3.0 3 0 0 3 3 3 0 PEHE domain SR-25 PF10500.9 CDI80104.1 - 0.16 11.5 19.6 0.017 14.8 7.5 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Methyltransf_25 PF13649.6 CDI80105.1 - 3.6e-11 43.6 0.1 1.3e-10 41.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CDI80105.1 - 5e-09 36.0 0.0 6.9e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 CDI80105.1 - 1.5e-08 35.1 0.0 5e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI80105.1 - 1.6e-08 34.5 0.1 3.1e-08 33.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI80105.1 - 3.8e-05 23.6 0.0 9.5e-05 22.3 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDI80105.1 - 0.00099 18.7 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 CDI80105.1 - 0.0021 17.0 0.0 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 CDI80105.1 - 0.024 15.4 0.0 0.057 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CDI80105.1 - 0.028 14.4 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CDI80105.1 - 0.052 13.3 0.1 0.091 12.5 0.1 1.4 1 0 0 1 1 1 0 Lysine methyltransferase DOT1 PF08123.13 CDI80105.1 - 0.063 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 PCMT PF01135.19 CDI80105.1 - 0.088 12.5 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ras PF00071.22 CDI80106.1 - 2.8e-21 75.8 0.1 2.9e-21 75.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI80106.1 - 5.7e-13 49.1 0.0 6.5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI80106.1 - 5.1e-05 22.8 0.0 5.3e-05 22.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family OATP PF03137.20 CDI80107.1 - 0.0011 17.4 0.1 0.0011 17.4 0.1 4.5 4 1 0 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family TFIIA PF03153.13 CDI80107.1 - 0.29 11.1 111.3 0.046 13.7 41.3 4.2 4 0 0 4 4 4 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.22 CDI80109.1 - 1.1e-14 54.0 0.0 4.2e-08 32.9 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2722 PF10846.8 CDI80109.1 - 0.00039 19.5 0.5 0.00039 19.5 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) ANAPC_CDC26 PF10471.9 CDI80109.1 - 0.0015 19.3 6.2 0.0028 18.4 6.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Limkain-b1 PF11608.8 CDI80109.1 - 0.0031 17.5 0.0 0.81 9.8 0.0 2.5 2 0 0 2 2 2 1 Limkain b1 TAF1D PF15333.6 CDI80109.1 - 0.0092 15.7 0.7 0.013 15.3 0.7 1.1 1 0 0 1 1 1 1 TATA box-binding protein-associated factor 1D FYTT PF07078.11 CDI80109.1 - 0.0099 15.2 6.8 0.02 14.2 6.8 1.4 1 1 0 1 1 1 1 Forty-two-three protein Hydin_ADK PF17213.3 CDI80109.1 - 0.16 12.2 4.0 0.27 11.5 4.0 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Spt20 PF12090.8 CDI80109.1 - 1.1 8.9 14.0 1.4 8.5 14.0 1.1 1 0 0 1 1 1 0 Spt20 family PKI PF02827.16 CDI80109.1 - 4.5 7.5 6.0 9.5 6.5 6.0 1.6 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Ribosomal_L37ae PF01780.19 CDI80110.1 - 0.029 14.4 0.4 0.029 14.4 0.4 2.4 2 0 0 2 2 2 0 Ribosomal L37ae protein family CNDH2_C PF16858.5 CDI80114.1 - 0.0024 17.8 18.1 0.0024 17.8 18.1 12.2 7 2 3 12 12 12 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term N6_N4_Mtase PF01555.18 CDI80114.1 - 3.1 7.4 0.0 3.1 7.4 0.0 6.7 5 3 0 5 5 5 0 DNA methylase TBCC PF07986.12 CDI80115.1 - 5e-14 52.1 0.1 1.3e-13 50.7 0.1 1.7 1 0 0 1 1 1 1 Tubulin binding cofactor C Activator_LAG-3 PF11498.8 CDI80115.1 - 0.0042 16.1 14.8 0.0042 16.1 14.8 3.8 4 0 0 4 4 4 2 Transcriptional activator LAG-3 RNase_H2_suC PF08615.11 CDI80115.1 - 0.02 15.1 0.6 4.8 7.3 0.0 3.1 3 0 0 3 3 3 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) MecA PF05389.12 CDI80115.1 - 0.049 13.3 11.6 0.92 9.1 0.1 3.2 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) SKICH PF17751.1 CDI80115.1 - 0.098 13.2 0.5 0.098 13.2 0.5 2.8 3 0 0 3 3 3 0 SKICH domain Spore_YhcN_YlaJ PF09580.10 CDI80115.1 - 0.25 11.4 9.0 5.5 7.0 0.0 3.0 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF4446 PF14584.6 CDI80115.1 - 0.52 10.3 0.0 0.52 10.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) FAM176 PF14851.6 CDI80115.1 - 0.86 9.3 11.9 0.92 9.2 1.3 3.3 3 0 0 3 3 3 0 FAM176 family Ank PF00023.30 CDI80116.1 - 6.8e-19 67.4 0.9 1.5e-07 31.5 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 CDI80116.1 - 8.6e-19 67.9 0.4 1.5e-12 47.9 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI80116.1 - 3.1e-17 60.9 0.2 1.5e-05 25.0 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 CDI80116.1 - 9.3e-15 54.8 0.2 1.5e-07 31.9 0.0 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDI80116.1 - 9e-13 48.2 0.5 5.9e-06 26.4 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) zf-CCCH PF00642.24 CDI80117.1 - 1.2e-08 34.6 10.5 6e-08 32.4 6.6 2.9 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI80117.1 - 0.032 14.3 8.5 0.032 14.3 8.5 2.2 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_4 PF18044.1 CDI80117.1 - 0.072 12.9 14.3 0.049 13.4 5.8 2.7 3 0 0 3 3 3 0 CCCH-type zinc finger Dehydrin PF00257.19 CDI80117.1 - 0.14 12.7 8.8 2.9 8.4 0.1 2.4 2 0 0 2 2 2 0 Dehydrin PMSI1 PF15322.6 CDI80117.1 - 0.17 11.3 5.8 0.27 10.6 5.8 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative FAM199X PF15814.5 CDI80117.1 - 1.4 7.9 6.7 2.6 7.0 6.7 1.4 1 0 0 1 1 1 0 Protein family FAM199X DUF3246 PF11596.8 CDI80117.1 - 1.8 8.0 7.7 5.2 6.4 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Peroxin-3 PF04882.12 CDI80117.1 - 1.8 7.5 7.1 2.3 7.1 0.2 2.3 2 0 0 2 2 2 0 Peroxin-3 TFIIF_alpha PF05793.12 CDI80117.1 - 6.2 5.3 15.5 0.17 10.4 4.4 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CRM1_C PF08767.11 CDI80118.1 - 2.4e-32 112.4 4.0 4.6e-31 108.2 0.1 3.3 3 0 0 3 3 3 1 CRM1 C terminal CRM1_repeat_3 PF18787.1 CDI80118.1 - 2.1e-25 88.5 2.1 2e-22 79.0 0.1 4.0 4 0 0 4 4 4 1 CRM1 / Exportin repeat 3 CRM1_repeat_2 PF18784.1 CDI80118.1 - 4.2e-18 64.8 0.6 8.3e-18 63.8 0.6 1.5 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 IBN_N PF03810.19 CDI80118.1 - 4e-11 42.7 0.0 1.6e-10 40.7 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CDI80118.1 - 8.1e-07 29.2 1.8 1.7e-05 24.9 0.6 3.5 3 2 1 4 4 4 1 Exportin 1-like protein UCH PF00443.29 CDI80118.1 - 0.067 12.7 0.0 0.2 11.1 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Vac14_Fab1_bd PF12755.7 CDI80118.1 - 0.089 13.4 0.1 2 9.0 0.0 3.0 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF4784 PF16023.5 CDI80118.1 - 0.15 11.0 0.3 7 5.5 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4784) Helicase_C PF00271.31 CDI80120.1 - 3.5e-26 91.7 0.0 9.1e-26 90.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GUCT PF08152.12 CDI80120.1 - 1.8e-07 31.3 0.0 5e-05 23.5 0.0 2.7 1 1 1 2 2 2 1 GUCT (NUC152) domain SUIM_assoc PF16619.5 CDI80120.1 - 0.018 15.1 3.5 0.018 15.1 3.5 2.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI80120.1 - 0.59 10.7 110.6 1.5 9.5 11.6 8.4 8 0 0 8 8 8 0 60s Acidic ribosomal protein DUF3446 PF11928.8 CDI80120.1 - 2.1 8.7 7.7 51 4.3 0.2 3.8 3 0 0 3 3 3 0 Early growth response N-terminal domain Spt20 PF12090.8 CDI80120.1 - 7.2 6.2 9.9 0.42 10.2 3.8 2.1 3 0 0 3 3 3 0 Spt20 family DUF2052 PF09747.9 CDI80121.1 - 0.01 15.9 28.2 0.01 15.9 28.2 1.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF5523 PF17661.1 CDI80121.1 - 0.2 11.3 33.0 0.25 11.0 33.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SOBP PF15279.6 CDI80121.1 - 0.21 12.2 18.0 0.24 12.0 18.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 CDI80121.1 - 0.52 8.5 29.4 0.53 8.5 29.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI80121.1 - 0.93 6.5 23.3 1 6.4 23.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CRT10 PF08728.10 CDI80121.1 - 1.2 7.2 10.8 1.3 7.1 10.8 1.1 1 0 0 1 1 1 0 CRT10 DUF4220 PF13968.6 CDI80121.1 - 1.3 8.4 5.1 2 7.7 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Nop14 PF04147.12 CDI80121.1 - 1.6 6.8 32.3 2.2 6.4 32.3 1.1 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 CDI80121.1 - 1.9 8.3 35.1 0.34 10.7 31.2 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CDI80121.1 - 2.2 6.5 31.8 3 6.0 31.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 CDI80121.1 - 2.4 7.6 18.8 3.4 7.1 18.8 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CCSAP PF15748.5 CDI80121.1 - 6.6 6.8 35.4 0.68 10.0 31.0 1.6 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated LAP1C PF05609.12 CDI80121.1 - 8 5.4 29.0 13 4.7 29.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SLC12 PF03522.15 CDI80121.1 - 9.8 5.1 29.5 13 4.7 29.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 AhpC-TSA PF00578.21 CDI80122.1 - 0.0058 16.6 0.0 0.017 15.0 0.0 1.8 1 0 0 1 1 1 1 AhpC/TSA family CNDH2_N PF06278.11 CDI80122.1 - 0.024 14.8 0.3 0.024 14.8 0.3 15.6 15 1 0 15 15 15 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal ATP19 PF11022.8 CDI80122.1 - 0.44 11.0 2.5 12 6.4 0.1 4.4 2 0 0 2 2 2 0 ATP synthase subunit K Cupin_8 PF13621.6 CDI80123.1 - 1.5e-22 80.5 0.0 1.4e-21 77.4 0.0 2.4 1 1 0 1 1 1 1 Cupin-like domain Spt20 PF12090.8 CDI80123.1 - 0.00054 19.6 29.3 0.083 12.5 7.0 3.2 3 0 0 3 3 3 3 Spt20 family TFIIA PF03153.13 CDI80123.1 - 0.037 14.0 35.5 0.67 9.9 26.7 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI80123.1 - 0.04 14.4 0.1 0.04 14.4 0.1 2.9 3 0 0 3 3 3 0 AAA domain ZapD PF07072.11 CDI80123.1 - 4.4 7.0 11.0 0.64 9.7 4.1 2.3 2 0 0 2 2 2 0 Cell division protein DUF572 PF04502.13 CDI80123.1 - 7 6.2 27.0 1.4 8.5 13.1 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI80124.1 - 2.9e-06 27.6 15.7 4.8e-06 26.8 15.7 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 CDI80124.1 - 0.089 11.7 13.6 0.13 11.2 13.6 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI80124.1 - 1.1 8.8 9.9 1.8 8.2 9.9 1.2 1 0 0 1 1 1 0 Spt20 family SDA1 PF05285.12 CDI80124.1 - 1.9 7.8 22.8 0.86 9.0 15.8 2.0 2 0 0 2 2 2 0 SDA1 Acyl-CoA_dh_1 PF00441.24 CDI80126.1 - 0.95 9.7 8.7 0.42 10.8 0.3 2.7 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Macoilin PF09726.9 CDI80126.1 - 1.6 7.2 17.7 1.1 7.7 8.7 2.1 2 0 0 2 2 2 0 Macoilin family Apt1 PF10351.9 CDI80126.1 - 2.2 7.0 15.3 0.14 11.0 4.9 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Corona_nucleoca PF00937.18 CDI80126.1 - 5 6.1 13.3 0.21 10.6 7.1 1.7 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein zf-CCCH PF00642.24 CDI80127.1 - 0.015 15.2 19.9 0.28 11.1 2.6 3.7 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1635 PF07795.11 CDI80127.1 - 1.6 8.5 11.5 0.045 13.6 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Lin-8 PF03353.15 CDI80127.1 - 2.3 7.7 8.1 3.2 7.2 1.7 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist FH2 PF02181.23 CDI80128.1 - 3.5e-67 227.1 0.3 4.6e-67 226.7 0.3 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain DUF787 PF05619.11 CDI80128.1 - 0.12 11.5 1.6 1.4 8.0 0.9 2.1 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF787) SR-25 PF10500.9 CDI80131.1 - 0.0047 16.6 24.2 0.0064 16.1 24.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Activator_LAG-3 PF11498.8 CDI80131.1 - 3.5 6.5 44.7 3.8 6.4 44.7 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF226 PF02890.14 CDI80133.1 - 0.016 15.2 0.0 0.071 13.1 0.0 2.2 1 0 0 1 1 1 0 Borrelia family of unknown function DUF226 RAB3GAP2_N PF14655.6 CDI80134.1 - 7.9e-25 88.0 5.8 8.3e-23 81.3 0.6 2.5 2 0 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus SUIM_assoc PF16619.5 CDI80134.1 - 0.0037 17.3 2.1 0.0037 17.3 2.1 4.7 3 1 1 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 BORG_CEP PF14957.6 CDI80134.1 - 0.77 10.9 18.5 1.3 10.2 4.9 3.2 3 0 0 3 3 3 0 Cdc42 effector NAD_binding_1 PF00175.21 CDI80135.1 - 1.9e-13 51.0 4.6 2.2e-07 31.5 0.2 3.6 3 1 1 4 4 4 2 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.25 CDI80135.1 - 0.0059 16.8 5.1 0.013 15.7 0.1 3.6 3 1 0 3 3 3 1 Flavodoxin TYW3 PF02676.14 CDI80135.1 - 0.1 11.9 7.5 2.8 7.2 0.1 3.3 3 0 0 3 3 3 0 Methyltransferase TYW3 YqzE PF14038.6 CDI80135.1 - 3.5 7.7 13.5 3.6 7.7 1.7 4.3 4 0 0 4 4 4 0 YqzE-like protein MCR_alpha PF02249.17 CDI80137.1 - 1.7 9.1 5.2 0.24 11.8 0.4 2.0 2 1 0 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain DUF4834 PF16118.5 CDI80138.1 - 0.015 16.3 0.5 0.015 16.3 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI80138.1 - 0.044 14.7 1.2 5.9 7.9 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4407 PF14362.6 CDI80138.1 - 0.083 12.2 8.7 0.12 11.7 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 CDI80138.1 - 0.095 11.4 8.3 0.12 11.1 8.3 1.3 1 0 0 1 1 1 0 Presenilin FAM199X PF15814.5 CDI80138.1 - 0.13 11.3 8.3 0.2 10.7 8.3 1.2 1 0 0 1 1 1 0 Protein family FAM199X PRC2_HTH_1 PF18118.1 CDI80138.1 - 1.1 10.1 7.4 11 6.9 1.9 2.5 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain DNA_pol_phi PF04931.13 CDI80138.1 - 1.1 7.2 14.6 0.12 10.5 0.5 2.4 2 1 0 2 2 2 0 DNA polymerase phi FAM176 PF14851.6 CDI80138.1 - 1.9 8.1 5.5 0.47 10.1 0.6 2.1 2 0 0 2 2 2 0 FAM176 family FRG PF08867.11 CDI80138.1 - 2.5 9.1 7.1 13 6.8 0.4 2.8 3 0 0 3 3 3 0 FRG domain DivIC PF04977.15 CDI80138.1 - 7 6.5 21.0 0.076 12.8 8.3 2.9 3 0 0 3 3 3 0 Septum formation initiator SRR1 PF07985.12 CDI80139.1 - 5.6e-14 51.9 1.5 1.1e-13 51.0 1.5 1.5 1 0 0 1 1 1 1 SRR1 Ribosomal_L38e PF01781.18 CDI80140.1 - 1.5e-29 101.9 0.6 1.7e-29 101.7 0.6 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Succ_CoA_lig PF13607.6 CDI80140.1 - 0.0048 16.7 0.1 0.0061 16.4 0.1 1.2 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain SUIM_assoc PF16619.5 CDI80143.1 - 0.03 14.4 2.0 0.03 14.4 2.0 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Methyltr_RsmB-F PF01189.17 CDI80144.1 - 5.5e-15 55.6 8.3 5.6e-07 29.4 0.1 4.3 4 1 0 4 4 4 2 16S rRNA methyltransferase RsmB/F CPSF100_C PF13299.6 CDI80144.1 - 1.4 9.0 9.2 7.5 6.7 3.8 3.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 CDI80144.1 - 2.3 8.3 7.7 0.97 9.5 1.6 2.5 3 0 0 3 3 3 0 DDHD domain GTP_EFTU PF00009.27 CDI80146.1 - 6.9e-57 192.1 0.0 1.8e-56 190.8 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CDI80146.1 - 3.9e-29 100.5 0.0 7.5e-29 99.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 CDI80146.1 - 7.9e-29 99.9 0.0 1.9e-28 98.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CDI80146.1 - 2.5e-22 78.7 0.0 5.6e-22 77.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDI80146.1 - 8.3e-12 45.3 0.1 2.7e-11 43.7 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDI80146.1 - 2e-05 24.4 0.1 4.9e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 CDI80146.1 - 0.043 14.3 0.0 0.66 10.5 0.0 2.6 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain ECH_2 PF16113.5 CDI80148.1 - 1.7e-73 248.0 0.0 9.1e-73 245.6 0.0 2.2 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDI80148.1 - 1.9e-26 92.9 0.0 9.1e-26 90.7 0.0 2.2 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase MMR_HSR1 PF01926.23 CDI80148.1 - 3.9e-12 46.3 0.0 1.2e-11 44.7 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDI80148.1 - 1.5e-09 37.7 0.0 8.3e-08 32.0 0.1 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 CDI80148.1 - 3.9e-07 29.6 0.3 0.001 18.5 0.0 2.8 2 0 0 2 2 2 2 Bacterial TniB protein AAA_16 PF13191.6 CDI80148.1 - 0.0089 16.4 4.1 0.0089 16.4 4.1 4.2 4 2 2 6 6 6 1 AAA ATPase domain FeoB_N PF02421.18 CDI80148.1 - 0.018 14.5 1.2 0.51 9.9 0.1 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDI80148.1 - 0.023 14.6 6.2 0.25 11.2 0.7 3.5 3 1 0 3 3 3 0 RsgA GTPase Roc PF08477.13 CDI80148.1 - 0.12 12.6 0.0 0.44 10.8 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pro_isomerase PF00160.21 CDI80149.1 - 6.9e-50 169.4 0.2 2.2e-49 167.8 0.1 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 CDI80149.1 - 1.9e-09 38.0 1.7 0.23 12.4 0.1 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI80149.1 - 0.15 12.4 0.0 1.9 8.8 0.0 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain EMP24_GP25L PF01105.24 CDI80151.1 - 1.3e-21 77.4 0.1 1.6e-21 77.1 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2183 PF09949.9 CDI80152.1 - 0.0052 17.1 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) DUF2722 PF10846.8 CDI80152.1 - 0.017 14.1 2.5 0.026 13.5 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) GRP PF07172.11 CDI80152.1 - 0.79 10.5 5.9 1.4e+02 3.2 0.0 3.4 3 0 0 3 3 3 0 Glycine rich protein family Spt20 PF12090.8 CDI80152.1 - 9.6 5.7 13.8 17 4.9 13.8 1.3 1 0 0 1 1 1 0 Spt20 family KH_6 PF15985.5 CDI80153.1 - 5.1e-10 39.6 0.0 9.9e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 KH domain Cyclin PF08613.11 CDI80154.1 - 3.4e-29 102.3 0.7 6.4e-29 101.4 0.0 1.8 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CDI80154.1 - 2.4e-11 43.5 0.1 3.7e-11 42.9 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain NAD_Gly3P_dh_N PF01210.23 CDI80155.1 - 2.9e-40 137.8 0.0 4.7e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 CDI80155.1 - 3.2e-38 131.2 0.1 5.3e-38 130.5 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus PfkB PF00294.24 CDI80157.1 - 8.2e-25 87.7 2.4 9.6e-19 67.8 0.5 2.5 1 1 0 2 2 2 2 pfkB family carbohydrate kinase Carb_kinase PF01256.17 CDI80157.1 - 0.025 14.1 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate kinase HEAT PF02985.22 CDI80158.1 - 0.017 15.3 14.7 2 8.9 0.0 7.0 6 0 0 6 6 6 0 HEAT repeat HECT PF00632.25 CDI80160.1 - 8.1e-34 117.5 0.0 1.9e-33 116.3 0.0 1.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 CDI80160.1 - 2.3e-07 31.3 0.3 5.1e-06 27.0 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 CDI80160.1 - 1.2e-06 28.6 0.0 2.7 8.6 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CDI80160.1 - 4.4e-05 23.7 0.0 0.47 10.8 0.1 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI80160.1 - 0.00024 21.6 0.1 0.13 12.9 0.1 4.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI80160.1 - 0.019 15.5 0.0 22 6.0 0.0 4.3 3 0 0 3 3 3 0 Ankyrin repeat TFIIA PF03153.13 CDI80161.1 - 0.0012 18.9 28.1 0.0013 18.8 28.1 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Usp PF00582.26 CDI80161.1 - 0.012 16.1 2.9 0.017 15.6 2.9 1.2 1 0 0 1 1 1 0 Universal stress protein family DUF3371 PF11851.8 CDI80161.1 - 0.027 15.6 11.5 0.042 14.9 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Med15 PF09606.10 CDI80161.1 - 0.031 13.0 24.2 0.033 12.9 24.2 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Androgen_recep PF02166.16 CDI80161.1 - 0.042 12.7 23.8 0.052 12.4 23.8 1.2 1 0 0 1 1 1 0 Androgen receptor DUF2722 PF10846.8 CDI80161.1 - 0.069 12.1 30.8 0.1 11.5 30.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI80161.1 - 0.094 12.3 41.8 0.12 11.9 41.8 1.1 1 0 0 1 1 1 0 Spt20 family Activator_LAG-3 PF11498.8 CDI80161.1 - 0.32 9.9 33.5 0.32 9.9 33.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SID-1_RNA_chan PF13965.6 CDI80161.1 - 0.34 9.2 4.8 0.32 9.4 4.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 CDI80161.1 - 0.65 9.8 18.8 0.73 9.6 18.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YABBY PF04690.13 CDI80161.1 - 0.74 10.4 9.5 0.88 10.1 9.5 1.2 1 0 0 1 1 1 0 YABBY protein Neur_chan_memb PF02932.16 CDI80161.1 - 0.95 9.5 10.5 0.97 9.4 10.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI80161.1 - 1 9.6 19.5 1.2 9.4 19.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein eIF-3_zeta PF05091.12 CDI80161.1 - 1.6 7.7 18.9 1.9 7.4 18.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF913 PF06025.12 CDI80161.1 - 1.6 7.6 11.7 1.7 7.5 11.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Band_3_cyto PF07565.13 CDI80161.1 - 2.1 8.1 12.6 2.6 7.8 12.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4746 PF15928.5 CDI80161.1 - 3.1 7.1 18.0 3.9 6.8 18.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI80161.1 - 3.2 5.5 15.6 3.4 5.5 15.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 CDI80161.1 - 3.2 6.6 6.9 3.8 6.3 6.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) BORG_CEP PF14957.6 CDI80161.1 - 4.3 8.5 12.3 5.9 8.1 12.3 1.2 1 0 0 1 1 1 0 Cdc42 effector PepSY_TM PF03929.16 CDI80161.1 - 6.2 6.4 6.2 7.4 6.1 6.2 1.1 1 0 0 1 1 1 0 PepSY-associated TM region FAM60A PF15396.6 CDI80161.1 - 6.4 6.7 16.8 7.5 6.5 16.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 CDI80161.1 - 7 5.6 13.6 9 5.2 13.6 1.1 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI80161.1 - 7.2 5.3 14.5 7.6 5.2 14.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CobT PF06213.12 CDI80161.1 - 9.8 5.5 28.1 27 4.0 28.2 1.7 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DXP_redisom_C PF08436.12 CDI80162.1 - 2.7e-34 117.2 0.0 5.8e-34 116.1 0.0 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain DXP_reductoisom PF02670.16 CDI80162.1 - 8.2e-29 100.9 3.2 8.2e-29 100.9 3.2 2.9 2 1 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.6 CDI80162.1 - 3.4e-10 40.2 0.0 3.4e-10 40.2 0.0 2.4 3 0 0 3 3 3 1 DXP reductoisomerase C-terminal domain Ribosomal_L9_N PF01281.19 CDI80163.1 - 7.4e-11 41.4 0.0 1.2e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Spt20 PF12090.8 CDI80163.1 - 1.3e-05 24.9 7.1 1.3e-05 24.9 7.1 3.0 2 1 0 2 2 1 1 Spt20 family SARAF PF06682.12 CDI80163.1 - 4.3e-05 23.3 0.0 0.00014 21.6 0.0 1.7 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 CDI80163.1 - 0.0015 19.4 16.5 0.013 16.5 2.4 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4834) dsDNA_bind PF01984.20 CDI80163.1 - 0.0033 17.7 9.9 0.0033 17.7 9.9 3.3 3 0 0 3 3 3 1 Double-stranded DNA-binding domain DUF2722 PF10846.8 CDI80163.1 - 0.0035 16.3 12.7 0.0035 16.3 12.7 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2722) ORC5_C PF14630.6 CDI80163.1 - 0.0093 15.5 3.8 0.14 11.6 0.3 2.1 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 5 C-terminus RskA PF10099.9 CDI80163.1 - 0.013 15.8 10.5 0.39 11.0 1.6 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA PIEZO PF15917.5 CDI80163.1 - 0.032 13.7 15.9 0.44 10.0 0.7 2.2 2 0 0 2 2 2 0 Piezo DUF913 PF06025.12 CDI80163.1 - 0.047 12.7 1.4 3.3 6.6 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Spore_III_AF PF09581.10 CDI80163.1 - 0.077 13.0 4.6 0.65 10.0 4.8 2.0 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Folliculin PF11704.8 CDI80163.1 - 0.099 12.5 8.2 0.84 9.5 2.1 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport RPA43_OB PF17875.1 CDI80163.1 - 0.12 13.0 0.4 0.12 13.0 0.4 3.0 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I DUF1764 PF08576.10 CDI80163.1 - 0.17 12.8 10.2 1.5 9.8 2.8 2.9 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) PA26 PF04636.13 CDI80163.1 - 0.26 10.2 10.3 0.35 9.7 3.4 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Eapp_C PF10238.9 CDI80163.1 - 0.73 9.9 12.6 0.12 12.4 1.8 3.0 3 0 0 3 3 3 0 E2F-associated phosphoprotein DUF4407 PF14362.6 CDI80163.1 - 1.7 7.9 19.1 0.53 9.6 6.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF5308 PF17233.2 CDI80163.1 - 2 8.6 11.5 1.2 9.3 2.2 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5308) eIF_4EBP PF05456.11 CDI80163.1 - 2.1 8.3 8.3 3.4 7.6 0.6 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Baculo_PP31 PF05311.11 CDI80163.1 - 2.5 7.5 10.6 2.2 7.7 5.0 2.2 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) FHIPEP PF00771.20 CDI80163.1 - 2.7 6.3 10.1 2.6 6.4 2.6 2.3 2 1 0 2 2 2 0 FHIPEP family eIF-3_zeta PF05091.12 CDI80163.1 - 3.3 6.6 20.4 3.9 6.3 9.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI80163.1 - 3.8 7.7 10.4 0.59 10.3 0.4 2.4 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.6 CDI80163.1 - 4.1 5.2 38.9 1.6 6.6 15.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) DUF3043 PF11241.8 CDI80163.1 - 5.4 7.0 16.3 15 5.6 10.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) DUF4770 PF15994.5 CDI80163.1 - 5.6 7.2 16.8 1.3 9.2 3.7 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) FYDLN_acid PF09538.10 CDI80163.1 - 6 7.6 8.7 0.77 10.5 0.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) FAM176 PF14851.6 CDI80163.1 - 7 6.3 10.8 4.6 6.9 2.3 2.9 3 0 0 3 3 3 0 FAM176 family PepSY_TM PF03929.16 CDI80163.1 - 7 6.2 8.9 4.2 6.9 0.9 2.3 2 0 0 2 2 2 0 PepSY-associated TM region SpoIIP PF07454.11 CDI80163.1 - 9.8 5.5 14.5 0.22 11.0 1.8 2.8 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Eaf7 PF07904.13 CDI80163.1 - 9.8 6.6 8.1 22 5.5 0.0 2.7 3 0 0 3 3 3 0 Chromatin modification-related protein EAF7 DUF702 PF05142.12 CDI80164.1 - 8.5 6.8 22.8 12 6.3 22.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) FAM176 PF14851.6 CDI80164.1 - 8.9 6.0 16.0 10 5.7 16.0 1.2 1 0 0 1 1 1 0 FAM176 family CobT PF06213.12 CDI80164.1 - 8.9 5.6 34.4 9.7 5.5 34.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF5308 PF17233.2 CDI80164.1 - 9.2 6.5 19.7 13 6.0 19.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) SNF2_N PF00176.23 CDI80165.1 - 7.8e-42 143.2 0.1 7.8e-42 143.2 0.1 2.5 3 0 0 3 3 3 1 SNF2 family N-terminal domain SPX PF03105.19 CDI80165.1 - 0.00016 21.8 2.7 0.00016 21.8 2.7 6.8 3 2 1 4 4 4 1 SPX domain Apt1 PF10351.9 CDI80165.1 - 0.0017 17.3 2.2 0.0017 17.3 2.2 6.5 5 2 0 6 6 6 1 Golgi-body localisation protein domain RskA PF10099.9 CDI80165.1 - 0.003 17.9 0.0 0.003 17.9 0.0 15.2 8 4 2 11 11 11 3 Anti-sigma-K factor rskA DUF3446 PF11928.8 CDI80165.1 - 0.004 17.4 7.2 0.004 17.4 7.2 13.7 11 4 2 14 14 14 3 Early growth response N-terminal domain HTH_23 PF13384.6 CDI80165.1 - 0.0043 16.8 0.8 0.039 13.8 0.8 2.8 1 0 0 1 1 1 1 Homeodomain-like domain HDA2-3 PF11496.8 CDI80165.1 - 0.82 8.8 0.0 0.82 8.8 0.0 3.1 3 0 0 3 3 3 0 Class II histone deacetylase complex subunits 2 and 3 HSP70 PF00012.20 CDI80166.1 - 6.1e-265 880.1 5.7 6.9e-265 879.9 5.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDI80166.1 - 5.1e-15 55.1 0.2 9.3e-13 47.7 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 CDI80166.1 - 0.0024 17.6 0.0 0.025 14.3 0.0 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 CDI80166.1 - 0.0031 16.8 0.1 0.0091 15.3 0.1 1.8 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase DDR PF08841.10 CDI80166.1 - 0.0043 16.1 0.5 0.34 9.8 0.3 2.4 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain PKK PF12474.8 CDI80166.1 - 1.1 9.4 10.4 0.55 10.3 6.3 2.1 2 0 0 2 2 2 0 Polo kinase kinase K_channel_TID PF07941.11 CDI80167.1 - 0.031 14.7 8.5 0.031 14.7 8.5 6.2 4 2 3 7 7 7 0 Potassium channel Kv1.4 tandem inactivation domain CcdA PF07362.12 CDI80167.1 - 0.45 11.0 0.1 0.45 11.0 0.1 4.9 5 1 0 5 5 5 0 Post-segregation antitoxin CcdA Syntaxin_2 PF14523.6 CDI80170.1 - 0.0054 17.1 6.4 7.4 7.0 0.0 4.3 3 1 1 4 4 4 2 Syntaxin-like protein Adeno_PIX PF03955.14 CDI80170.1 - 0.018 15.2 0.8 0.079 13.1 0.8 2.1 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) RapH_N PF18801.1 CDI80170.1 - 3 8.0 6.7 1.5 8.9 2.1 2.7 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal Histone PF00125.24 CDI80171.1 - 3.7e-53 179.4 1.5 4.2e-53 179.2 1.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CDI80171.1 - 9.1e-05 22.8 0.0 0.00014 22.2 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 CDI80171.1 - 0.00023 21.7 1.3 0.00028 21.5 1.3 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDI80171.1 - 0.0004 20.5 0.1 0.00074 19.6 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 CDI80171.1 - 0.0094 16.0 0.1 0.015 15.3 0.0 1.4 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDI80171.1 - 0.015 15.6 0.1 0.029 14.7 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NFACT-R_1 PF05670.13 CDI80172.1 - 8.6e-40 135.8 0.0 1.5e-39 135.0 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain LicD PF04991.13 CDI80172.1 - 0.14 12.3 6.4 0.17 12.0 6.4 1.1 1 0 0 1 1 1 0 LicD family DUF853 PF05872.12 CDI80172.1 - 1 7.9 6.5 1.3 7.5 6.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Transformer PF06495.11 CDI80172.1 - 1.2 9.2 7.4 1.8 8.7 7.4 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein DUF1943 PF09172.11 CDI80172.1 - 7.2 5.8 9.8 10 5.2 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) tRNA-synt_1g PF09334.11 CDI80174.1 - 9.6e-19 67.4 14.7 6.9e-10 38.2 0.0 5.1 6 0 0 6 6 6 4 tRNA synthetases class I (M) SPX PF03105.19 CDI80174.1 - 7.9e-06 26.0 4.7 7.9e-06 26.0 4.7 3.9 1 1 1 2 2 2 1 SPX domain DUF2114 PF09887.9 CDI80174.1 - 0.068 11.7 0.1 0.1 11.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2114) MRP-L47 PF06984.13 CDI80174.1 - 0.1 12.7 0.9 0.48 10.6 0.9 2.2 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) V_ATPase_I PF01496.19 CDI80174.1 - 1.1 7.1 19.1 0.04 11.9 1.6 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Lipoprotein_22 PF17294.2 CDI80175.1 - 0.17 11.6 6.8 0.31 10.7 6.8 1.3 1 0 0 1 1 1 0 Uncharacterised lipoprotein family Mif2_N PF15624.6 CDI80176.1 - 0.0008 20.1 7.1 0.087 13.5 4.6 2.4 2 0 0 2 2 2 2 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Sigma70_ner PF04546.13 CDI80176.1 - 0.003 17.5 7.6 0.006 16.5 7.6 1.5 1 0 0 1 1 1 1 Sigma-70, non-essential region RP-C_C PF11800.8 CDI80176.1 - 0.028 14.5 2.4 0.045 13.8 2.4 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region TFB6 PF17110.5 CDI80176.1 - 0.07 12.9 4.9 0.11 12.2 4.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Nucleoside_tran PF01733.18 CDI80176.1 - 0.21 10.9 0.7 0.29 10.5 0.7 1.2 1 0 0 1 1 1 0 Nucleoside transporter ABC_trans_N PF14510.6 CDI80176.1 - 0.67 10.6 5.1 0.54 10.9 1.3 2.5 3 0 0 3 3 3 0 ABC-transporter N-terminal AFT PF08731.11 CDI80177.1 - 0.19 12.1 11.0 0.24 11.8 11.0 1.2 1 0 0 1 1 1 0 Transcription factor AFT Tim54 PF11711.8 CDI80177.1 - 4 6.1 21.2 4.4 6.0 21.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3408 PF11888.8 CDI80177.1 - 4.2 7.5 26.0 5.1 7.2 26.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF789 PF05623.12 CDI80177.1 - 4.2 7.0 19.7 4.3 6.9 19.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) CobT PF06213.12 CDI80177.1 - 6 6.2 29.4 7.5 5.8 29.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 CDI80177.1 - 6.6 6.4 17.6 8.3 6.1 17.6 1.1 1 0 0 1 1 1 0 FAM176 family SpoIIP PF07454.11 CDI80177.1 - 7.3 6.0 24.5 9.6 5.6 24.5 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) GOLD_2 PF13897.6 CDI80177.1 - 8.1 6.9 6.7 9.1 6.8 6.7 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking zf-rbx1 PF12678.7 CDI80179.1 - 1.1e-20 73.7 10.5 1.8e-20 73.0 10.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDI80179.1 - 1.2e-15 57.3 8.1 1.8e-15 56.8 8.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CDI80179.1 - 0.001 19.3 12.7 0.035 14.4 12.7 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDI80179.1 - 0.0047 16.7 1.2 0.0047 16.7 1.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDI80179.1 - 0.0086 15.8 2.5 0.0086 15.8 2.5 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDI80179.1 - 0.013 15.3 9.8 0.13 12.1 9.8 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDI80179.1 - 0.12 12.6 7.0 0.76 10.0 7.3 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain SR-25 PF10500.9 CDI80179.1 - 0.24 11.0 15.4 0.31 10.6 15.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med3 PF11593.8 CDI80179.1 - 0.3 10.2 5.8 0.41 9.8 5.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-HC5HC2H_2 PF13832.6 CDI80179.1 - 0.61 10.3 9.4 1.2 9.3 9.4 1.6 1 1 0 1 1 1 0 PHD-zinc-finger like domain Zn_ribbon_17 PF17120.5 CDI80179.1 - 0.76 9.4 13.7 0.39 10.4 4.5 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type DUF1645 PF07816.11 CDI80179.1 - 2.2 8.9 10.2 2.8 8.5 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) zf-HC5HC2H PF13771.6 CDI80179.1 - 2.4 8.5 10.8 66 3.9 10.8 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain AF-4 PF05110.13 CDI80180.1 - 0.11 10.5 36.2 0.14 10.3 36.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein GPCR_chapero_1 PF11904.8 CDI80180.1 - 0.22 10.9 19.7 0.29 10.5 19.7 1.1 1 0 0 1 1 1 0 GPCR-chaperone Macoilin PF09726.9 CDI80180.1 - 0.22 10.0 25.7 0.31 9.6 25.7 1.2 1 0 0 1 1 1 0 Macoilin family YukD PF08817.10 CDI80180.1 - 0.25 12.0 1.1 0.95 10.2 0.2 2.2 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Vac7 PF12751.7 CDI80180.1 - 0.29 10.5 22.3 0.37 10.2 22.3 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 CDC45 PF02724.14 CDI80180.1 - 0.53 8.5 30.7 0.65 8.2 30.7 1.1 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 CDI80180.1 - 0.79 6.8 29.3 1 6.4 29.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI80180.1 - 2 6.6 58.6 2.5 6.3 58.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CSRNP_N PF16019.5 CDI80180.1 - 2.7 7.9 29.7 4 7.3 29.7 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus CENP-N PF05238.13 CDI80180.1 - 3.1 7.0 24.7 4 6.7 24.7 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Hid1 PF12722.7 CDI80180.1 - 5.1 5.1 32.8 6.5 4.7 32.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LAP1C PF05609.12 CDI80180.1 - 6.1 5.8 35.3 9.2 5.2 35.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) JAB PF01398.21 CDI80182.1 - 5.8e-12 45.6 0.0 9.8e-10 38.4 0.0 2.4 2 0 0 2 2 2 2 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HMG_box_2 PF09011.10 CDI80182.1 - 0.13 12.9 0.9 36 5.1 0.1 3.2 2 2 0 2 2 2 0 HMG-box domain FliD_N PF02465.18 CDI80183.1 - 0.015 15.9 13.2 0.019 15.6 13.2 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Spt20 PF12090.8 CDI80183.1 - 0.13 11.9 23.4 0.16 11.6 23.4 1.1 1 0 0 1 1 1 0 Spt20 family Draxin PF15550.6 CDI80183.1 - 0.32 10.8 5.9 0.38 10.6 5.9 1.0 1 0 0 1 1 1 0 Draxin Peptidase_C58 PF03543.14 CDI80183.1 - 0.44 10.2 13.0 0.52 10.0 13.0 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Sec62 PF03839.16 CDI80183.1 - 0.82 9.1 4.8 0.89 9.0 4.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2722 PF10846.8 CDI80183.1 - 0.86 8.5 16.1 1.1 8.1 16.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) WASH-7_C PF14746.6 CDI80183.1 - 1.2 8.8 7.6 1.5 8.5 7.6 1.2 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal TERB2 PF15101.6 CDI80183.1 - 1.5 8.9 12.7 1.6 8.7 12.7 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Dynactin_p62 PF05502.13 CDI80183.1 - 1.5 7.5 9.4 1.8 7.2 9.4 1.0 1 0 0 1 1 1 0 Dynactin p62 family Med15 PF09606.10 CDI80183.1 - 1.7 7.2 22.4 1.8 7.2 22.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Activator_LAG-3 PF11498.8 CDI80183.1 - 2.1 7.2 28.4 2.4 7.0 28.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI80183.1 - 3.6 7.5 24.8 4.2 7.3 24.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4481 PF14800.6 CDI80183.1 - 3.7 6.9 7.5 4.9 6.6 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) Ribosomal_S13 PF00416.22 CDI80184.1 - 7.3e-52 175.1 0.8 8.6e-52 174.9 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CDI80184.1 - 0.012 14.4 0.0 0.012 14.4 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF1631 PF07793.11 CDI80187.1 - 0.094 11.1 17.3 0.091 11.2 17.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) CDP-OH_P_tran_2 PF08009.11 CDI80187.1 - 0.33 10.9 1.8 0.49 10.3 1.8 1.2 1 0 0 1 1 1 0 CDP-alcohol phosphatidyltransferase 2 HSP70 PF00012.20 CDI80187.1 - 9.9 4.2 22.3 12 3.9 22.3 1.0 1 0 0 1 1 1 0 Hsp70 protein CLP1_P PF16575.5 CDI80188.1 - 1.9e-12 47.4 9.6 1.2e-10 41.5 0.0 3.4 3 1 0 3 3 3 2 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_29 PF13555.6 CDI80188.1 - 0.048 13.4 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.23 CDI80188.1 - 0.079 13.0 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 CDI80188.1 - 0.13 12.0 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 CDI80188.1 - 0.28 11.7 1.3 0.48 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDI80188.1 - 0.32 10.7 0.9 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMU163 PF17119.5 CDI80188.1 - 0.44 9.7 4.1 0.91 8.6 4.1 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis SLC12 PF03522.15 CDI80188.1 - 5.1 6.0 12.3 10 5.0 12.3 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Ureide_permease PF07168.11 CDI80188.1 - 8.4 5.0 7.0 19 3.9 0.1 2.3 2 0 0 2 2 2 0 Ureide permease AUX_IAA PF02309.16 CDI80188.1 - 9.6 6.0 12.0 6.5 6.5 8.2 2.1 2 0 0 2 2 2 0 AUX/IAA family TFIIA PF03153.13 CDI80190.1 - 0.0029 17.7 37.1 0.0029 17.7 37.1 7.9 2 2 5 7 7 7 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI80190.1 - 0.0066 16.1 24.6 0.0066 16.1 24.6 12.1 5 3 2 9 9 9 1 Spt20 family ABC_trans_N PF14510.6 CDI80191.1 - 3.7 8.2 8.1 17 6.1 5.6 3.0 2 1 0 2 2 2 0 ABC-transporter N-terminal IGPS PF00218.21 CDI80192.1 - 4.6e-20 71.9 3.1 4.6e-20 71.9 3.1 4.6 5 0 0 5 5 5 1 Indole-3-glycerol phosphate synthase NAM-associated PF14303.6 CDI80192.1 - 3.9e-08 34.2 0.0 3.9e-08 34.2 0.0 8.0 4 2 3 7 7 7 1 No apical meristem-associated C-terminal domain Activator_LAG-3 PF11498.8 CDI80192.1 - 6.8e-08 31.9 36.8 6.8e-08 31.9 36.8 5.4 5 0 0 5 5 5 1 Transcriptional activator LAG-3 DUF4179 PF13786.6 CDI80192.1 - 0.69 10.4 0.0 0.69 10.4 0.0 6.1 6 1 0 6 6 6 0 Domain of unknown function (DUF4179) Sel1 PF08238.12 CDI80194.1 - 4e-09 36.8 8.3 0.021 15.5 0.0 6.1 6 0 0 6 6 6 3 Sel1 repeat SUIM_assoc PF16619.5 CDI80194.1 - 0.00025 21.1 0.7 0.00025 21.1 0.7 5.2 4 1 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 DUF3446 PF11928.8 CDI80194.1 - 0.021 15.1 5.4 0.021 15.1 5.4 5.1 3 1 1 4 4 4 0 Early growth response N-terminal domain DUF1645 PF07816.11 CDI80194.1 - 3.6 8.1 18.6 0.068 13.7 3.7 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1645) Ribosomal_L13 PF00572.18 CDI80195.1 - 1.5e-10 41.3 2.8 5.5e-09 36.4 0.2 2.9 2 1 0 2 2 2 1 Ribosomal protein L13 RRM_1 PF00076.22 CDI80200.1 - 8.3e-29 99.2 0.0 3.2e-17 62.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI80200.1 - 9e-06 25.7 0.1 5e-05 23.3 0.1 2.3 2 2 0 2 2 2 1 RNA recognition motif Pkinase PF00069.25 CDI80201.1 - 8.8e-44 149.8 0.1 7.8e-40 136.9 0.0 3.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80201.1 - 3.1e-28 98.8 0.0 4.9e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI80201.1 - 1.1e-07 31.4 0.0 2.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDI80201.1 - 2.8e-06 26.4 0.0 4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Tubulin PF00091.25 CDI80202.1 - 1.8e-21 77.3 0.0 3.6e-14 53.4 0.0 2.1 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 CDI80202.1 - 0.02 15.2 0.0 0.034 14.5 0.0 1.3 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Dynein_C PF18199.1 CDI80203.1 - 7.1e-42 143.7 0.1 2.9e-41 141.7 0.0 1.7 1 1 1 2 2 2 1 Dynein heavy chain C-terminal domain AAA_6 PF12774.7 CDI80204.1 - 1.1e-120 402.6 1.1 4.1e-119 397.4 0.0 3.0 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI80204.1 - 3.9e-82 276.5 1.4 3.9e-82 276.5 1.4 3.1 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 MT PF12777.7 CDI80204.1 - 8.8e-57 192.7 3.7 1.8e-56 191.6 3.7 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 CDI80204.1 - 4e-51 173.2 0.0 4e-51 173.2 0.0 3.7 5 0 0 5 5 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 CDI80204.1 - 3.4e-49 167.5 0.0 1.4e-48 165.5 0.0 2.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 CDI80204.1 - 1.8e-29 102.5 0.0 5.9e-17 61.8 0.0 4.6 4 0 0 4 4 4 3 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 CDI80204.1 - 8.5e-17 61.5 0.0 2.4e-16 60.0 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDI80204.1 - 9.4e-06 25.7 0.0 0.00025 21.1 0.0 3.3 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 CDI80204.1 - 1.8e-05 24.7 5.2 0.27 11.2 0.0 5.4 5 1 0 5 5 5 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDI80204.1 - 0.00052 20.3 6.5 8.3 6.7 0.0 6.0 5 0 0 5 5 5 1 AAA domain AAA PF00004.29 CDI80204.1 - 0.0012 19.3 0.5 0.41 11.1 0.0 4.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_lid_1 PF17857.1 CDI80204.1 - 0.007 16.6 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsK_SpoIIIE PF01580.18 CDI80204.1 - 0.067 12.5 0.6 5.7 6.2 0.1 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CDI80204.1 - 0.12 12.8 0.7 23 5.4 0.1 3.2 3 0 0 3 3 3 0 RNA helicase LCE6A PF15858.5 CDI80206.1 - 0.035 14.8 3.6 0.097 13.4 0.5 2.6 2 0 0 2 2 2 0 Late cornified envelope protein 6A family DUF4148 PF13663.6 CDI80207.1 - 0.0071 16.5 3.6 0.0071 16.5 3.6 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4148) RuvC_III PF18541.1 CDI80207.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 Kin17_mid PF10357.9 CDI80208.1 - 1.8e-42 144.2 3.7 1.8e-42 144.2 3.7 1.8 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 CDI80208.1 - 5.5e-21 74.4 1.1 1.1e-20 73.5 1.1 1.5 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain NdhS PF11623.8 CDI80208.1 - 0.046 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S zf-3CxxC_2 PF17180.4 CDI80210.1 - 0.00019 22.1 24.1 0.00019 22.1 24.1 9.9 8 3 0 8 8 8 1 Zinc-binding domain ABC_tran PF00005.27 CDI80211.1 - 4.3e-05 24.0 0.0 6.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDI80211.1 - 0.00048 19.6 0.1 0.00064 19.2 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Clathrin PF00637.20 CDI80213.1 - 4.6e-06 26.6 0.6 0.0052 16.7 0.0 2.8 2 1 0 2 2 2 2 Region in Clathrin and VPS PPR PF01535.20 CDI80213.1 - 0.019 15.2 4.6 95 3.6 0.0 5.1 4 0 0 4 4 4 0 PPR repeat Coatomer_WDAD PF04053.14 CDI80213.1 - 0.089 11.8 5.6 0.86 8.6 0.4 2.2 2 0 0 2 2 2 0 Coatomer WD associated region TPR_14 PF13428.6 CDI80213.1 - 0.17 12.8 20.7 4.3 8.4 0.5 6.5 4 2 2 6 6 6 0 Tetratricopeptide repeat DUF3293 PF11697.8 CDI80213.1 - 8.6 6.9 9.2 2.4 8.7 0.2 3.8 3 2 1 4 4 4 0 Protein of unknown function (DUF3293) OAD_gamma PF04277.13 CDI80214.1 - 0.034 14.7 3.9 0.034 14.7 3.9 4.3 3 1 0 3 3 2 0 Oxaloacetate decarboxylase, gamma chain Cytokin-bind PF09265.10 CDI80214.1 - 0.15 11.4 5.2 0.28 10.5 5.2 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding FAM76 PF16046.5 CDI80214.1 - 0.29 10.4 16.8 0.4 10.0 16.8 1.2 1 0 0 1 1 1 0 FAM76 protein FapA PF03961.13 CDI80214.1 - 0.36 9.4 11.4 0.54 8.8 11.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 CDI80214.1 - 0.41 9.5 11.5 0.67 8.8 11.5 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2009 PF09418.10 CDI80214.1 - 0.82 8.7 8.8 1.3 8.1 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) DUF812 PF05667.11 CDI80214.1 - 1.2 7.9 28.8 2 7.2 28.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) YabA PF06156.13 CDI80214.1 - 1.8 9.2 18.3 0.049 14.3 6.3 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Atg14 PF10186.9 CDI80214.1 - 2.2 7.3 23.7 3.2 6.7 23.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlaC_arch PF05377.11 CDI80214.1 - 4.7 7.7 6.6 3.7 8.0 1.1 2.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Goodbye PF17109.5 CDI80214.1 - 6.4 7.2 15.3 0.3 11.5 3.6 3.1 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain Na_sulph_symp PF00939.19 CDI80217.1 - 5.1e-20 72.0 2.7 7.3e-18 64.8 0.5 2.2 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CDI80217.1 - 5e-10 39.1 24.1 4e-09 36.1 6.9 2.5 2 1 0 2 2 2 2 Citrate transporter TIMELESS PF04821.14 CDI80217.1 - 0.13 11.5 0.1 0.22 10.7 0.1 1.2 1 0 0 1 1 1 0 Timeless protein Spt20 PF12090.8 CDI80217.1 - 3.3 7.3 9.4 5.2 6.6 9.4 1.2 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 CDI80217.1 - 5.9 5.9 6.0 11 5.0 6.0 1.4 1 0 0 1 1 1 0 Drosophila roughex protein TFIIA PF03153.13 CDI80219.1 - 0.0056 16.7 13.6 0.0056 16.7 13.6 2.7 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI80219.1 - 0.0069 17.1 14.0 0.0069 17.1 14.0 3.4 3 0 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PUB PF09409.10 CDI80219.1 - 0.12 12.4 0.0 0.41 10.6 0.0 1.9 1 1 0 1 1 1 0 PUB domain DUF4179 PF13786.6 CDI80219.1 - 3.2 8.3 8.5 4.2 7.9 0.7 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4179) TFIIA PF03153.13 CDI80220.1 - 6.6e-08 33.0 55.7 1.4e-05 25.3 36.2 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Mpp10 PF04006.12 CDI80220.1 - 9.5e-05 21.0 36.8 0.00081 18.0 24.3 2.3 2 0 0 2 2 2 2 Mpp10 protein eIF-3_zeta PF05091.12 CDI80220.1 - 0.00095 18.3 33.1 0.0077 15.3 20.5 2.1 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CDC27 PF09507.10 CDI80220.1 - 0.001 18.6 24.1 0.001 18.6 24.1 2.1 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 Velvet PF11754.8 CDI80220.1 - 0.0088 16.0 22.3 0.087 12.7 14.9 2.3 2 0 0 2 2 2 2 Velvet factor Apt1 PF10351.9 CDI80220.1 - 0.012 14.5 15.0 0.011 14.7 6.7 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Hamartin PF04388.12 CDI80220.1 - 0.014 14.1 29.7 0.017 13.9 16.1 2.1 2 0 0 2 2 2 0 Hamartin protein Endostatin PF06482.11 CDI80220.1 - 0.029 13.8 27.2 0.31 10.4 19.6 2.2 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Cwf_Cwc_15 PF04889.12 CDI80220.1 - 0.046 13.5 35.1 0.075 12.7 22.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TT_ORF1 PF02956.14 CDI80220.1 - 0.057 12.1 16.7 0.33 9.6 0.4 2.1 2 0 0 2 2 2 0 TT viral orf 1 HCO3_cotransp PF00955.21 CDI80220.1 - 0.061 12.1 12.4 1.4 7.6 0.1 2.1 2 0 0 2 2 2 0 HCO3- transporter family PAT1 PF09770.9 CDI80220.1 - 0.075 11.3 52.3 0.095 11.0 37.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SAPS PF04499.15 CDI80220.1 - 0.084 11.7 25.3 1 8.0 19.8 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein PNISR PF15996.5 CDI80220.1 - 0.094 13.0 49.7 0.096 13.0 34.7 2.5 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SDA1 PF05285.12 CDI80220.1 - 0.18 11.2 41.4 0.088 12.2 29.4 2.2 2 0 0 2 2 2 0 SDA1 BAF1_ABF1 PF04684.13 CDI80220.1 - 0.32 10.0 38.7 0.79 8.7 26.4 2.3 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor CSG2 PF16965.5 CDI80220.1 - 0.5 9.2 20.1 0.25 10.3 12.7 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator PPL5 PF18168.1 CDI80220.1 - 0.57 9.4 26.7 0.4 9.9 15.9 2.5 3 0 0 3 3 2 0 Prim-pol family 5 SLC12 PF03522.15 CDI80220.1 - 0.62 9.0 35.9 1.6 7.7 25.1 2.2 2 0 0 2 2 2 0 Solute carrier family 12 NPR1_interact PF15699.5 CDI80220.1 - 0.78 10.4 52.2 0.59 10.8 17.9 3.5 2 1 1 3 3 3 0 NPR1 interacting RPN2_C PF18004.1 CDI80220.1 - 0.94 9.4 44.4 0.18 11.7 23.4 3.2 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4045 PF13254.6 CDI80220.1 - 0.97 9.0 33.5 0.7 9.5 23.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) ALMT PF11744.8 CDI80220.1 - 1.1 8.0 28.5 1.3 7.8 18.3 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter Rrn6 PF10214.9 CDI80220.1 - 1.2 7.6 34.4 1.7 7.1 23.0 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor SID-1_RNA_chan PF13965.6 CDI80220.1 - 1.4 7.2 17.2 0.91 7.8 10.3 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Serinc PF03348.15 CDI80220.1 - 1.5 7.7 21.6 4.2 6.2 0.4 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) CAC1F_C PF16885.5 CDI80220.1 - 1.7 8.3 30.9 0.28 10.8 20.6 2.3 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term SOBP PF15279.6 CDI80220.1 - 2.8 8.4 25.0 3.8 8.0 16.3 2.3 2 0 0 2 2 2 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 CDI80220.1 - 3.1 6.4 27.1 0.28 9.8 15.0 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF2370 PF10176.9 CDI80220.1 - 5.1 6.7 18.2 4.8 6.7 11.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF2151 PF10221.9 CDI80220.1 - 6.4 5.2 23.5 0.97 7.9 14.1 2.2 2 0 0 2 2 2 0 Cell cycle and development regulator DUF572 PF04502.13 CDI80220.1 - 8.4 5.9 48.0 7.3 6.1 9.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF2464 PF10240.9 CDI80220.1 - 8.5 5.9 17.8 14 5.1 12.1 2.2 2 0 0 2 2 2 0 Multivesicular body subunit 12 SUIM_assoc PF16619.5 CDI80221.1 - 0.041 14.0 0.2 0.041 14.0 0.2 3.5 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 RAB3GAP2_N PF14655.6 CDI80221.1 - 0.29 10.4 6.3 1.1 8.5 2.4 2.6 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF2722 PF10846.8 CDI80221.1 - 2.1 7.2 18.1 0.11 11.4 5.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Med3 PF11593.8 CDI80221.1 - 2.4 7.3 23.9 5.1 6.2 1.2 2.5 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Hydin_ADK PF17213.3 CDI80221.1 - 5.9 7.1 14.5 11 6.2 11.0 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain CpXC PF14353.6 CDI80221.1 - 8.1 6.5 8.8 0.73 9.9 1.0 3.0 3 0 0 3 3 3 0 CpXC protein DUF1676 PF07898.13 CDI80221.1 - 9.1 6.3 0.0 9.1 6.3 0.0 3.5 3 1 0 4 4 4 0 Protein of unknown function (DUF1676) Hydrolase_4 PF12146.8 CDI80225.1 - 2.1e-06 27.2 0.0 7.6e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 YabA PF06156.13 CDI80227.1 - 0.00073 20.1 10.1 0.0013 19.4 10.1 1.4 1 0 0 1 1 1 1 Initiation control protein YabA DUF2205 PF10224.9 CDI80227.1 - 0.0024 17.8 5.8 0.0024 17.8 5.8 2.1 1 1 1 2 2 1 1 Short coiled-coil protein CENP-F_leu_zip PF10473.9 CDI80227.1 - 0.0083 16.1 12.7 0.014 15.4 12.7 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 CDI80227.1 - 0.021 15.2 1.0 0.021 15.2 1.0 1.9 2 0 0 2 2 1 0 Flagella accessory protein C (FlaC) Ribosomal_L29 PF00831.23 CDI80227.1 - 0.053 13.5 0.4 0.053 13.5 0.4 2.8 1 1 1 2 2 2 0 Ribosomal L29 protein V_ATPase_I PF01496.19 CDI80227.1 - 0.094 10.6 7.2 0.11 10.4 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RAP1 PF07218.11 CDI80227.1 - 0.28 9.4 5.7 0.37 9.0 5.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HAUS6_N PF14661.6 CDI80227.1 - 0.37 10.3 7.6 0.53 9.8 7.6 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus UPF0242 PF06785.11 CDI80227.1 - 0.75 9.9 13.7 1 9.5 13.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AAA_23 PF13476.6 CDI80227.1 - 0.78 10.2 9.9 1.1 9.7 9.9 1.3 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 CDI80227.1 - 0.88 8.3 10.7 0.51 9.1 9.4 1.2 1 1 0 1 1 1 0 Aluminium activated malate transporter Mod_r PF07200.13 CDI80227.1 - 1.6 8.8 16.7 0.65 10.1 14.0 1.6 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Macoilin PF09726.9 CDI80227.1 - 2.8 6.4 23.1 4.9 5.6 23.1 1.4 1 1 0 1 1 1 0 Macoilin family Borrelia_P83 PF05262.11 CDI80227.1 - 4.9 5.5 11.5 5.7 5.3 11.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SOBP PF15279.6 CDI80227.1 - 8.3 6.9 16.7 11 6.5 16.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Cwf_Cwc_15 PF04889.12 CDI80230.1 - 0.042 13.6 8.6 0.051 13.3 8.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PA26 PF04636.13 CDI80230.1 - 0.084 11.8 5.2 0.09 11.7 5.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) TFIIA PF03153.13 CDI80230.1 - 0.59 10.1 37.5 0.68 9.9 37.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI80230.1 - 1.8 8.5 7.2 2.3 8.2 7.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.9 CDI80230.1 - 3.4 5.8 20.3 3.8 5.7 20.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hamartin PF04388.12 CDI80230.1 - 4.9 5.7 10.9 5.4 5.6 10.9 1.0 1 0 0 1 1 1 0 Hamartin protein CCSAP PF15748.5 CDI80230.1 - 5.1 7.2 14.3 6.6 6.8 14.3 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Hid1 PF12722.7 CDI80230.1 - 7.2 4.6 9.0 7.6 4.5 9.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DDRGK PF09756.9 CDI80230.1 - 7.2 6.2 17.2 9.5 5.8 17.2 1.1 1 0 0 1 1 1 0 DDRGK domain RR_TM4-6 PF06459.12 CDI80230.1 - 7.5 6.3 13.0 8.9 6.0 13.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI80230.1 - 9.8 6.1 7.5 11 6.0 7.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 CDI80230.1 - 9.9 4.8 17.1 12 4.6 17.1 1.1 1 0 0 1 1 1 0 Presenilin GAS2 PF02187.17 CDI80232.1 - 0.096 12.8 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain Cullin PF00888.22 CDI80233.1 - 6e-50 170.5 0.0 6.9e-48 163.7 0.0 2.0 2 0 0 2 2 2 2 Cullin family DUF3446 PF11928.8 CDI80233.1 - 0.00031 21.0 1.6 0.00067 19.9 1.6 1.5 1 0 0 1 1 1 1 Early growth response N-terminal domain SR-25 PF10500.9 CDI80233.1 - 0.015 14.9 7.7 0.023 14.3 7.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI80233.1 - 0.091 13.5 4.7 0.24 12.1 4.7 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF755 PF05501.11 CDI80233.1 - 7 7.0 15.1 4.4 7.6 12.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Spt20 PF12090.8 CDI80234.1 - 0.0029 17.2 14.6 0.0044 16.7 14.6 1.2 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI80234.1 - 0.0053 15.8 10.6 0.009 15.0 10.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) RCR PF12273.8 CDI80234.1 - 0.015 16.0 3.3 0.048 14.3 3.3 1.9 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF3464 PF11947.8 CDI80234.1 - 0.026 14.3 2.8 0.045 13.5 2.8 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Suf PF05843.14 CDI80234.1 - 0.067 13.2 4.8 0.089 12.8 4.8 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CaKB PF03185.15 CDI80234.1 - 0.08 12.6 0.8 0.11 12.2 0.8 1.2 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Spore_coat_CotO PF14153.6 CDI80234.1 - 0.52 10.2 12.6 0.86 9.5 12.6 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Presenilin PF01080.17 CDI80234.1 - 0.58 8.9 4.9 0.78 8.4 4.9 1.2 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDI80234.1 - 1.7 7.6 8.3 3.1 6.8 8.3 1.4 1 0 0 1 1 1 0 Drosophila roughex protein SR-25 PF10500.9 CDI80234.1 - 4 7.0 15.3 0.92 9.1 7.3 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ctr PF04145.15 CDI80234.1 - 4.4 7.9 6.3 1.2 9.7 2.7 1.7 2 0 0 2 2 2 0 Ctr copper transporter family OmpH PF03938.14 CDI80234.1 - 4.4 7.6 18.5 8 6.8 18.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PAT1 PF09770.9 CDI80234.1 - 6.5 4.9 15.8 8.9 4.4 15.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TSP_1 PF00090.19 CDI80235.1 - 2.8e-06 27.4 0.8 2.8e-06 27.4 0.8 3.1 2 0 0 2 2 2 1 Thrombospondin type 1 domain TcdB_N PF12918.7 CDI80235.1 - 0.056 13.8 0.1 0.16 12.3 0.1 1.8 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Peroxin-13_N PF04088.13 CDI80235.1 - 0.22 11.8 6.7 0.49 10.7 0.3 2.8 2 0 0 2 2 2 0 Peroxin 13, N-terminal region DUF3405 PF11885.8 CDI80235.1 - 6.5 5.2 10.8 0.4 9.2 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) PAN_4 PF14295.6 CDI80236.1 - 5.4e-14 51.8 21.4 0.00024 20.9 0.5 5.1 5 0 0 5 5 5 4 PAN domain PAN_1 PF00024.26 CDI80236.1 - 1.1e-09 38.1 25.0 0.00042 20.2 0.6 5.6 4 1 1 5 5 5 4 PAN domain PAN_2 PF08276.11 CDI80236.1 - 0.82 9.8 29.1 0.2 11.8 0.5 5.2 5 0 0 5 5 5 0 PAN-like domain AAA_23 PF13476.6 CDI80240.1 - 0.12 12.9 12.4 2 8.8 0.3 3.2 3 0 0 3 3 3 0 AAA domain DUF4578 PF15147.6 CDI80240.1 - 0.96 10.3 16.8 3 8.7 3.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) E1_dh PF00676.20 CDI80241.1 - 0.017 14.1 0.5 0.017 14.1 0.5 2.2 2 1 0 3 3 3 0 Dehydrogenase E1 component AP2 PF00847.20 CDI80241.1 - 0.71 10.1 0.1 0.71 10.1 0.1 2.2 1 1 1 2 2 2 0 AP2 domain Pro_isomerase PF00160.21 CDI80242.1 - 1.5e-27 96.8 0.0 8.9e-27 94.3 0.0 2.3 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IMUP PF15761.5 CDI80242.1 - 0.00058 20.5 8.3 0.00058 20.5 8.3 5.2 4 1 1 5 5 5 1 Immortalisation up-regulated protein AF-4 PF05110.13 CDI80242.1 - 2 6.4 45.5 4 5.4 45.5 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Condensation PF00668.20 CDI80246.1 - 5.4 5.6 9.7 0.48 9.0 0.0 3.4 4 0 0 4 4 4 0 Condensation domain HEAT PF02985.22 CDI80247.1 - 0.17 12.2 2.1 1.3 9.4 0.1 3.8 2 0 0 2 2 2 0 HEAT repeat JmjC PF02373.22 CDI80250.1 - 4.5e-34 117.3 1.3 4.5e-34 117.3 1.3 2.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase Sporozoite_P67 PF05642.11 CDI80250.1 - 0.00056 18.1 0.4 0.00056 18.1 0.4 3.1 3 1 1 4 4 4 1 Sporozoite P67 surface antigen JmjN PF02375.17 CDI80250.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 jmjN domain Arf PF00025.21 CDI80251.1 - 5.3e-22 78.1 0.0 2.1e-12 46.9 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF2722 PF10846.8 CDI80251.1 - 1.8e-05 23.9 5.9 2.6e-05 23.4 5.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) SRPRB PF09439.10 CDI80251.1 - 0.0041 16.6 0.0 0.23 10.9 0.0 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDI80251.1 - 0.011 16.0 1.0 1.4 9.1 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDI80251.1 - 0.013 15.6 0.0 0.1 12.7 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase 7tm_1 PF00001.21 CDI80251.1 - 0.079 12.3 2.9 0.15 11.4 2.9 1.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Presenilin PF01080.17 CDI80251.1 - 0.097 11.4 2.6 0.15 10.8 2.6 1.4 1 0 0 1 1 1 0 Presenilin G-alpha PF00503.20 CDI80251.1 - 0.11 11.6 0.2 0.44 9.6 0.1 2.0 2 1 0 2 2 2 0 G-protein alpha subunit TFIIA PF03153.13 CDI80251.1 - 0.14 12.2 20.8 0.33 10.9 20.6 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4366 PF14283.6 CDI80251.1 - 0.28 11.2 9.3 0.31 11.1 1.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) Activator_LAG-3 PF11498.8 CDI80251.1 - 1.1 8.2 24.5 1.8 7.5 24.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Gtr1_RagA PF04670.12 CDI80251.1 - 1.2 8.4 3.2 31 3.8 0.0 2.8 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region Arf PF00025.21 CDI80252.1 - 6.2e-07 29.0 0.0 7.1e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Pex14_N PF04695.13 CDI80252.1 - 2.6e-05 24.9 3.4 3e-05 24.7 3.4 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 CDI80252.1 - 5.4e-05 22.9 10.8 6.9e-05 22.6 10.8 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4964 PF16334.5 CDI80252.1 - 0.046 13.3 0.2 0.094 12.3 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4964) FAM199X PF15814.5 CDI80252.1 - 0.053 12.6 8.4 0.063 12.3 8.4 1.1 1 0 0 1 1 1 0 Protein family FAM199X NRBF2 PF08961.10 CDI80252.1 - 0.2 11.2 4.5 0.28 10.8 4.5 1.1 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator CCSAP PF15748.5 CDI80252.1 - 0.21 11.7 6.8 0.28 11.3 6.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CCDC106 PF15794.5 CDI80252.1 - 0.38 10.4 6.9 0.48 10.1 6.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Suf PF05843.14 CDI80252.1 - 0.44 10.5 5.1 0.49 10.3 5.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Herpes_pp85 PF04637.12 CDI80252.1 - 1 7.7 7.2 1.1 7.6 7.2 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Presenilin PF01080.17 CDI80252.1 - 1.5 7.5 4.4 1.8 7.3 4.4 1.1 1 0 0 1 1 1 0 Presenilin Corona_nucleoca PF00937.18 CDI80252.1 - 5.1 6.0 11.2 6.4 5.7 11.2 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein IMUP PF15761.5 CDI80253.1 - 0.028 15.1 2.1 0.028 15.1 2.1 7.1 6 2 1 7 7 7 0 Immortalisation up-regulated protein Helicase_C PF00271.31 CDI80254.1 - 6.4e-07 29.7 0.0 6.4e-07 29.7 0.0 6.1 4 1 0 5 5 5 2 Helicase conserved C-terminal domain ORC_WH_C PF18137.1 CDI80254.1 - 0.0044 17.1 2.6 0.0044 17.1 2.6 18.6 10 5 0 10 10 10 3 Origin recognition complex winged helix C-terminal MarC PF01914.17 CDI80254.1 - 0.47 9.8 6.2 0.61 9.4 0.2 4.4 3 0 0 3 3 3 0 MarC family integral membrane protein cNMP_binding PF00027.29 CDI80255.1 - 2.8e-21 75.4 0.4 3.8e-20 71.8 0.4 2.3 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain SUIM_assoc PF16619.5 CDI80255.1 - 0.46 10.6 15.1 0.18 11.9 2.8 3.7 2 2 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF3138 PF11336.8 CDI80255.1 - 0.93 8.0 19.9 1.4 7.5 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) YfhO PF09586.10 CDI80255.1 - 2.3 6.3 5.2 2.8 6.1 5.2 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO RskA PF10099.9 CDI80255.1 - 2.7 8.3 31.3 0.55 10.5 0.2 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA EIIBC-GUT_N PF03612.14 CDI80255.1 - 3.2 7.5 7.4 0.13 12.0 0.7 2.0 2 1 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus SR-25 PF10500.9 CDI80257.1 - 0.0024 17.5 1.3 0.003 17.2 1.3 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4701 PF15773.5 CDI80257.1 - 0.0025 16.9 3.4 0.0028 16.7 3.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) DUF3446 PF11928.8 CDI80257.1 - 0.0043 17.3 0.5 0.0051 17.1 0.5 1.2 1 0 0 1 1 1 1 Early growth response N-terminal domain Abhydrolase_1 PF00561.20 CDI80257.1 - 0.007 16.0 0.4 0.0081 15.8 0.4 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2722 PF10846.8 CDI80257.1 - 0.011 14.7 12.9 0.014 14.3 12.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4598 PF15370.6 CDI80257.1 - 0.02 15.4 1.1 0.023 15.2 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) MRI PF15325.6 CDI80257.1 - 0.052 14.6 2.2 0.076 14.1 2.2 1.2 1 0 0 1 1 1 0 Modulator of retrovirus infection DUF4834 PF16118.5 CDI80257.1 - 0.061 14.3 2.7 0.075 14.0 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI80257.1 - 0.082 12.5 13.6 0.097 12.3 13.6 1.2 1 0 0 1 1 1 0 Spt20 family Spore_III_AF PF09581.10 CDI80257.1 - 0.088 12.8 3.8 0.12 12.4 3.8 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) SprA-related PF12118.8 CDI80257.1 - 0.29 10.2 12.2 0.34 10.0 12.2 1.0 1 0 0 1 1 1 0 SprA-related family EOS1 PF12326.8 CDI80257.1 - 0.35 10.8 2.7 0.44 10.5 2.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.17 CDI80257.1 - 0.85 8.3 4.1 0.92 8.2 4.1 1.0 1 0 0 1 1 1 0 Presenilin Androgen_recep PF02166.16 CDI80257.1 - 2 7.1 9.0 2.4 6.9 9.0 1.1 1 0 0 1 1 1 0 Androgen receptor RRM_1 PF00076.22 CDI80258.1 - 2e-28 98.0 0.6 8.7e-15 54.3 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI80258.1 - 8.4e-11 41.9 0.4 0.00025 21.1 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif Apt1 PF10351.9 CDI80258.1 - 1e-05 24.6 2.6 1.1e-05 24.5 2.6 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain SPX PF03105.19 CDI80258.1 - 0.00011 22.3 5.6 0.00013 22.0 5.6 1.1 1 0 0 1 1 1 1 SPX domain BUD22 PF09073.10 CDI80258.1 - 0.0074 15.7 4.9 0.0093 15.3 4.9 1.1 1 0 0 1 1 1 1 BUD22 SOG2 PF10428.9 CDI80258.1 - 0.12 11.6 12.9 0.15 11.2 12.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DHHW PF14286.6 CDI80258.1 - 0.12 11.6 3.4 0.19 11.0 3.4 1.2 1 0 0 1 1 1 0 DHHW protein DUF2151 PF10221.9 CDI80258.1 - 0.44 9.1 2.7 0.61 8.6 2.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Pkinase_fungal PF17667.1 CDI80258.1 - 0.78 8.5 2.8 1.1 8.0 2.8 1.1 1 0 0 1 1 1 0 Fungal protein kinase Sporozoite_P67 PF05642.11 CDI80258.1 - 1 7.4 11.3 1.3 7.0 11.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 CDI80258.1 - 1.1 8.0 8.3 1.5 7.5 8.3 1.1 1 0 0 1 1 1 0 Presenilin Smg8_Smg9 PF10220.9 CDI80258.1 - 1.5 7.0 5.3 2.1 6.5 5.3 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Hid1 PF12722.7 CDI80258.1 - 1.7 6.7 6.0 2.2 6.3 6.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CDI80258.1 - 4.1 4.4 11.0 5.5 4.0 11.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI80258.1 - 4.1 5.8 21.1 6.2 5.3 21.1 1.1 1 0 0 1 1 1 0 Macoilin family Secretin_N_2 PF07655.13 CDI80258.1 - 5.5 7.6 27.2 11 6.6 27.2 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain FAM199X PF15814.5 CDI80258.1 - 5.6 5.9 23.2 8.5 5.3 23.2 1.2 1 0 0 1 1 1 0 Protein family FAM199X ANAPC_CDC26 PF10471.9 CDI80258.1 - 5.9 7.8 6.6 14 6.6 6.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Med15 PF09606.10 CDI80259.1 - 0.022 13.4 58.8 0.026 13.2 58.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Hamartin PF04388.12 CDI80259.1 - 0.53 8.9 39.5 0.64 8.6 39.5 1.0 1 0 0 1 1 1 0 Hamartin protein LMBR1 PF04791.16 CDI80259.1 - 2.3 7.0 13.8 2.6 6.8 13.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5585 PF17823.1 CDI80259.1 - 4.2 6.2 54.4 5.1 5.9 54.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Helicase_C_2 PF13307.6 CDI80260.1 - 1e-07 32.3 0.0 1e-07 32.3 0.0 3.6 3 2 0 3 3 3 1 Helicase C-terminal domain zf-C3HC4_3 PF13920.6 CDI80260.1 - 1.3e-06 28.1 8.3 2.4e-06 27.3 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDI80260.1 - 9.3e-06 25.4 6.7 2.1e-05 24.3 6.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CDI80260.1 - 3e-05 23.8 6.3 6.1e-05 22.8 6.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI80260.1 - 0.0044 17.3 7.2 0.0085 16.4 7.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CDI80260.1 - 0.02 14.8 9.0 0.023 14.6 5.9 2.6 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.25 CDI80260.1 - 0.044 13.7 3.3 0.17 11.8 3.6 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CDI80260.1 - 0.18 11.6 5.9 0.38 10.6 5.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 CDI80260.1 - 0.53 10.5 6.4 1.2 9.3 5.6 2.0 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 CDI80260.1 - 1.4 9.0 4.7 4.5 7.4 1.9 3.0 1 1 1 2 2 2 0 RING-type zinc-finger Hamartin PF04388.12 CDI80262.1 - 1.7 7.2 28.3 0.21 10.2 11.5 2.1 2 0 0 2 2 2 0 Hamartin protein PP-binding_2 PF14573.6 CDI80263.1 - 9.2e-13 48.2 0.0 1.2e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-carrier FKBP_C PF00254.28 CDI80264.1 - 3.6e-29 100.9 0.0 5.3e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 CDI80265.1 - 4e-09 35.9 12.5 0.00035 20.5 0.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDI80265.1 - 1.2e-07 31.3 4.0 0.00057 19.5 0.1 3.1 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.28 CDI80265.1 - 2.9e-07 30.0 7.8 0.019 14.8 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDI80265.1 - 1.1e-06 29.1 1.2 0.0024 18.3 0.3 2.6 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI80265.1 - 7.3e-06 26.4 1.6 0.0095 16.7 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI80265.1 - 2.6e-05 24.1 4.3 0.015 15.5 0.2 3.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI80265.1 - 2.9e-05 24.6 5.4 0.00014 22.4 3.8 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI80265.1 - 0.00012 22.2 0.1 0.68 10.5 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDI80265.1 - 0.0012 18.9 0.1 0.0024 18.0 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Pro_isomerase PF00160.21 CDI80265.1 - 0.0033 17.7 0.0 0.007 16.7 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_12 PF13424.6 CDI80265.1 - 0.007 16.6 2.6 0.079 13.3 0.7 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI80265.1 - 0.048 13.9 3.6 0.051 13.8 0.4 2.5 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDI80265.1 - 0.34 11.6 3.2 20 6.1 0.1 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat ATG16 PF08614.11 CDI80265.1 - 1.1 9.5 8.6 0.12 12.5 1.4 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) ArfGap PF01412.18 CDI80268.1 - 2.3e-27 95.4 0.0 4.6e-27 94.4 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf YihI PF04220.12 CDI80268.1 - 0.073 12.8 0.6 0.2 11.4 0.6 1.7 1 0 0 1 1 1 0 Der GTPase activator (YihI) zf_CCCH_4 PF18345.1 CDI80270.1 - 0.00014 21.7 6.2 0.00014 21.7 6.2 1.6 2 0 0 2 2 2 1 Zinc finger domain Torus PF16131.5 CDI80270.1 - 0.00019 22.1 0.1 0.00019 22.1 0.1 3.1 3 0 0 3 3 3 1 Torus domain zf-CCCH PF00642.24 CDI80270.1 - 0.004 17.0 4.6 0.004 17.0 4.6 1.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SUIM_assoc PF16619.5 CDI80270.1 - 0.0079 16.2 3.1 0.0079 16.2 3.1 5.3 4 2 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 zf-CCCH_4 PF18044.1 CDI80270.1 - 0.056 13.3 5.5 0.11 12.4 5.5 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDI80270.1 - 0.15 12.5 5.7 0.25 11.9 5.7 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger SR-25 PF10500.9 CDI80275.1 - 0.012 15.2 1.3 0.017 14.8 1.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI80275.1 - 0.6 10.0 11.8 0.75 9.7 11.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YajC PF02699.15 CDI80275.1 - 8.6 6.3 7.6 17 5.4 7.6 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit PhoLip_ATPase_N PF16209.5 CDI80276.1 - 1.9e-10 40.3 0.2 3.2e-10 39.5 0.2 1.3 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal CCDC106 PF15794.5 CDI80276.1 - 6.2 6.5 7.5 7.6 6.2 7.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RNA_polI_A34 PF08208.11 CDI80277.1 - 0.0052 16.9 0.9 0.0086 16.2 0.9 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 SUIM_assoc PF16619.5 CDI80277.1 - 0.0082 16.2 3.6 0.017 15.2 3.6 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 SPX PF03105.19 CDI80277.1 - 0.14 12.1 4.8 0.32 10.9 4.5 1.5 1 1 1 2 2 2 0 SPX domain CCSAP PF15748.5 CDI80277.1 - 0.22 11.7 4.9 0.31 11.2 4.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Spt20 PF12090.8 CDI80277.1 - 2.2 7.8 6.9 3.5 7.2 6.9 1.2 1 0 0 1 1 1 0 Spt20 family AP2 PF00847.20 CDI80280.1 - 2 8.7 5.2 2.5 8.4 0.0 3.7 3 0 0 3 3 3 0 AP2 domain TPR_2 PF07719.17 CDI80281.1 - 0.002 18.1 0.0 3.5 8.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI80281.1 - 0.0079 16.4 2.9 0.75 10.1 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CDI80281.1 - 0.015 15.1 0.3 4.4 7.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI80282.1 - 4.4e-16 58.9 3.3 3e-05 24.2 0.4 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CDI80282.1 - 6.6e-16 58.6 0.2 1.8e-05 25.1 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDI80282.1 - 3.2e-10 39.3 10.5 0.024 14.7 1.6 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDI80282.1 - 4.1e-09 36.5 6.0 0.0089 16.6 1.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDI80282.1 - 3.4e-08 33.7 5.0 0.013 15.8 0.1 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI80282.1 - 2.2e-07 31.4 4.6 0.017 15.7 0.1 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI80282.1 - 3.4e-07 29.8 10.0 0.17 11.7 1.7 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDI80282.1 - 5e-07 29.3 1.9 0.09 12.9 0.2 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI80282.1 - 9.6e-07 29.1 4.3 0.013 16.2 0.4 4.1 5 0 0 5 5 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI80282.1 - 0.00028 20.9 4.5 2.8 8.1 0.2 3.9 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 CDI80282.1 - 0.014 15.6 4.9 1.7 9.1 0.7 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 CDI80282.1 - 0.015 15.5 1.9 17 6.0 0.1 4.7 5 0 0 5 5 5 0 PPR repeat TPR_10 PF13374.6 CDI80282.1 - 0.026 14.4 2.8 5.7 7.0 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CDI80282.1 - 0.032 13.6 0.7 2.6 7.4 0.0 2.5 2 1 1 3 3 3 0 Coatomer epsilon subunit TPR_9 PF13371.6 CDI80282.1 - 0.034 14.3 0.8 4.8 7.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 CDI80282.1 - 0.075 12.4 0.6 11 5.4 0.0 2.2 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP SRP_TPR_like PF17004.5 CDI80282.1 - 0.075 13.1 0.0 11 6.1 0.0 2.9 3 0 0 3 3 3 0 Putative TPR-like repeat TEX29 PF15839.5 CDI80282.1 - 0.11 13.1 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 Testis-expressed sequence 29 protein TPR_3 PF07720.12 CDI80282.1 - 0.11 12.5 8.3 1.3 9.1 2.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDI80282.1 - 1.6 8.4 5.2 20 5.0 1.3 2.8 3 0 0 3 3 3 0 TPR repeat SUI1 PF01253.22 CDI80283.1 - 2e-10 41.1 0.0 4.5e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 CDI80283.1 - 0.0026 18.4 0.1 0.0074 16.9 0.0 1.9 2 0 0 2 2 2 1 Pre-PUA-like domain Methyltransf_19 PF04672.12 CDI80283.1 - 0.0076 15.8 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl methyltransferase Ilar_coat PF01787.16 CDI80283.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Ilarvirus coat protein zf-His_Me_endon PF05551.11 CDI80284.1 - 0.0085 16.3 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding loop region of homing endonuclease Aldo_ket_red PF00248.21 CDI80285.1 - 7.5e-28 97.6 0.8 3.1e-23 82.4 0.1 3.1 1 1 1 2 2 2 2 Aldo/keto reductase family HSCB_C PF07743.13 CDI80285.1 - 3 8.4 6.2 1.3 9.5 1.0 2.7 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Aldo_ket_red PF00248.21 CDI80286.1 - 8.7e-33 113.8 0.0 1.4e-30 106.5 0.0 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1943 PF09172.11 CDI80287.1 - 0.025 13.9 0.0 0.068 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) TPR_1 PF00515.28 CDI80288.1 - 1.6e-06 27.6 6.2 0.074 12.9 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI80288.1 - 4.2e-05 24.1 6.8 4.2e-05 24.1 6.8 5.9 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI80288.1 - 5.9e-05 22.7 0.5 0.054 13.2 0.0 3.0 2 1 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 CDI80288.1 - 0.00054 19.9 5.1 0.0016 18.4 2.0 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDI80288.1 - 0.0048 17.0 1.5 0.24 11.7 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI80288.1 - 0.0063 17.2 3.3 0.0063 17.2 3.3 6.5 5 2 2 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI80288.1 - 0.0091 16.0 0.4 0.0091 16.0 0.4 2.1 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CDI80288.1 - 0.043 14.4 0.8 0.043 14.4 0.8 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat AlaDh_PNT_C PF01262.21 CDI80293.1 - 0.0028 17.0 0.2 0.0046 16.3 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF5421 PF17458.2 CDI80293.1 - 0.0037 16.7 3.2 0.0037 16.7 3.2 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5421) Roughex PF06020.11 CDI80293.1 - 0.019 14.1 3.0 0.035 13.2 3.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein NAD_binding_8 PF13450.6 CDI80293.1 - 0.099 12.9 0.6 0.23 11.7 0.6 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Spt20 PF12090.8 CDI80293.1 - 7.5 6.1 15.1 0.095 12.3 7.6 1.6 2 0 0 2 2 2 0 Spt20 family tRNA-synt_1c PF00749.21 CDI80294.1 - 4.7e-74 249.1 0.0 8.7e-38 130.0 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain GST_C_2 PF13410.6 CDI80294.1 - 8.5e-08 32.1 0.1 5.6e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDI80294.1 - 0.00019 21.6 0.0 0.00068 19.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDI80294.1 - 0.14 12.4 0.0 0.44 10.8 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SUIM_assoc PF16619.5 CDI80294.1 - 9.9 6.3 9.5 23 5.1 9.5 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CRT-like PF08627.10 CDI80296.1 - 1.7e-44 152.1 2.0 7.4e-36 123.8 1.6 2.0 1 1 1 2 2 2 2 CRT-like, chloroquine-resistance transporter-like ASFV_J13L PF05568.11 CDI80296.1 - 0.62 9.8 2.0 1.1 9.0 2.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein TFIIA PF03153.13 CDI80297.1 - 0.14 12.1 21.8 0.23 11.4 21.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DNA_topoisoIV PF00521.20 CDI80299.1 - 1.2e-74 251.7 2.2 1e-45 156.4 0.0 2.1 1 1 1 2 2 2 2 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CDI80299.1 - 3.9e-08 32.6 0.6 4.8e-05 22.7 0.1 3.2 3 0 0 3 3 3 2 DNA gyrase C-terminal domain, beta-propeller HrpB7 PF09486.10 CDI80299.1 - 0.015 15.7 15.3 0.015 15.7 15.3 1.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) VSG_B PF13206.6 CDI80299.1 - 0.056 12.7 6.7 0.11 11.8 6.7 1.4 1 0 0 1 1 1 0 Trypanosomal VSG domain Methyltransf_14 PF08484.11 CDI80299.1 - 0.5 10.2 3.5 0.29 10.9 0.5 1.9 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain Cbl_N PF02262.16 CDI80299.1 - 2.2 8.3 9.2 1.7 8.7 6.3 2.0 1 1 1 2 2 2 0 CBL proto-oncogene N-terminal domain 1 DUF1664 PF07889.12 CDI80299.1 - 2.6 8.1 11.1 8.1 6.5 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 CDI80299.1 - 3.8 6.3 7.5 5.2 5.9 7.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_S46 PF10459.9 CDI80299.1 - 4 5.9 9.9 6.9 5.2 9.9 1.3 1 0 0 1 1 1 0 Peptidase S46 Laminin_II PF06009.12 CDI80299.1 - 4.4 7.3 14.2 8.4 6.4 3.0 2.4 2 0 0 2 2 2 0 Laminin Domain II TFIIA PF03153.13 CDI80299.1 - 9.8 6.0 21.6 0.25 11.3 14.3 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PNTB PF02233.16 CDI80300.1 - 1.1e-27 97.2 0.0 1.9e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CDI80300.1 - 9.6e-21 74.1 0.0 1.6e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TPP_enzyme_M PF00205.22 CDI80300.1 - 0.0013 18.5 0.1 0.0031 17.3 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain FAD_oxidored PF12831.7 CDI80300.1 - 0.0036 16.7 2.1 0.0036 16.7 2.1 1.9 2 0 0 2 2 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDI80300.1 - 0.0044 15.8 1.2 0.0065 15.2 1.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CDI80300.1 - 0.0052 16.1 0.1 0.0088 15.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDI80300.1 - 0.0095 16.1 0.4 0.03 14.6 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Glu_dehyd_C PF16912.5 CDI80300.1 - 0.01 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus FAD_binding_2 PF00890.24 CDI80300.1 - 0.028 13.5 2.1 0.048 12.7 2.1 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 CDI80300.1 - 0.05 12.7 0.8 0.078 12.1 0.8 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CDI80300.1 - 0.11 11.8 0.9 0.23 10.6 0.9 1.5 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 CDI80300.1 - 0.12 11.6 0.1 0.2 10.9 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDI80300.1 - 0.13 12.7 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.17 CDI80300.1 - 0.13 11.5 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_N PF05222.15 CDI80300.1 - 0.15 12.4 0.0 11 6.4 0.0 2.6 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, N-terminal domain O-antigen_lig PF13425.6 CDI80301.1 - 8.4 5.1 15.7 0.24 10.1 8.4 1.9 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Tox-MPTase2 PF15638.6 CDI80305.1 - 0.51 10.0 2.1 0.59 9.8 0.7 1.8 2 1 1 3 3 3 0 Metallopeptidase toxin 2 SR-25 PF10500.9 CDI80309.1 - 0.00021 21.0 45.9 0.00021 21.0 45.9 1.6 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 CDI80309.1 - 0.0036 16.2 21.4 0.0047 15.9 21.4 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 CDI80309.1 - 0.15 10.5 26.5 0.18 10.2 26.5 1.2 1 0 0 1 1 1 0 Peptidase family S64 CytochromB561_N PF09786.9 CDI80309.1 - 1.1 8.1 19.2 1.3 7.9 19.2 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal TFIIF_alpha PF05793.12 CDI80309.1 - 1.2 7.6 38.2 2.1 6.9 38.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LCD1 PF09798.9 CDI80309.1 - 1.2 7.5 19.9 1.6 7.2 19.9 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein Mem_trans PF03547.18 CDI80309.1 - 6.2 5.1 12.2 8.4 4.7 12.2 1.2 1 0 0 1 1 1 0 Membrane transport protein FAM220 PF15487.6 CDI80309.1 - 7 6.2 22.7 12 5.4 22.7 1.4 1 0 0 1 1 1 0 FAM220 family Ribosomal_60s PF00428.19 CDI80311.1 - 0.16 12.6 32.2 0.56 10.8 2.7 3.3 3 0 0 3 3 3 0 60s Acidic ribosomal protein Macoilin PF09726.9 CDI80311.1 - 5.5 5.4 7.4 10 4.5 7.4 1.5 1 0 0 1 1 1 0 Macoilin family MyTH4 PF00784.17 CDI80314.1 - 1.9e-16 60.5 3.6 4.7e-16 59.2 3.6 1.7 1 1 0 1 1 1 1 MyTH4 domain DUF4487 PF14868.6 CDI80314.1 - 0.05 12.4 1.2 0.085 11.7 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) Amino_oxidase PF01593.24 CDI80315.1 - 2.5e-10 40.2 0.0 1.3e-08 34.6 0.0 2.9 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDI80315.1 - 0.027 14.7 0.0 0.11 12.8 0.0 2.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Tri3 PF07428.11 CDI80315.1 - 0.045 12.7 0.0 0.085 11.8 0.0 1.3 1 0 0 1 1 1 0 15-O-acetyltransferase Tri3 SUIM_assoc PF16619.5 CDI80315.1 - 0.25 11.4 25.0 0.15 12.1 6.1 3.7 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 YlbD_coat PF14071.6 CDI80315.1 - 4.1 7.7 12.1 1.5 9.1 3.4 2.7 2 0 0 2 2 2 0 Putative coat protein Patatin PF01734.22 CDI80316.1 - 3.5e-28 99.2 4.6 3.5e-28 99.2 4.6 4.3 4 1 0 4 4 4 1 Patatin-like phospholipase Skp1_POZ PF03931.15 CDI80317.1 - 7.6e-09 35.6 0.0 2.3e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Methyltr_RsmB-F PF01189.17 CDI80318.1 - 3.9e-32 111.5 0.0 2.2e-31 109.0 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Ubie_methyltran PF01209.18 CDI80318.1 - 1.1e-09 38.0 0.0 1.6e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDI80318.1 - 5.4e-08 32.8 0.0 8.6e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI80318.1 - 1.2e-05 25.9 0.0 2.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDI80318.1 - 0.0037 17.0 0.0 0.0057 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CDI80318.1 - 0.0048 16.5 0.0 0.11 12.0 0.0 2.2 1 1 0 2 2 2 1 Methyltransferase small domain GCD14 PF08704.10 CDI80318.1 - 0.014 15.0 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit UPF0020 PF01170.18 CDI80318.1 - 0.02 14.6 0.0 0.056 13.1 0.0 1.7 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 PASTA PF03793.19 CDI80318.1 - 0.065 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 PASTA domain FtsJ PF01728.19 CDI80318.1 - 0.086 12.9 0.0 0.15 12.1 0.0 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 CDI80318.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) EMP70 PF02990.16 CDI80319.1 - 3.3e-128 428.6 4.8 1.1e-68 232.2 0.0 2.0 1 1 1 2 2 2 2 Endomembrane protein 70 Ribosomal_L14e PF01929.17 CDI80320.1 - 2.1e-30 105.0 4.2 2.8e-30 104.6 4.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CDI80320.1 - 0.067 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 KOW motif PPTA PF01239.22 CDI80321.1 - 9.5e-12 44.2 4.3 0.0025 17.5 0.0 4.4 4 0 0 4 4 4 3 Protein prenyltransferase alpha subunit repeat SpoIIIAH PF12685.7 CDI80321.1 - 0.94 9.3 36.9 2.9 7.7 0.1 4.4 4 1 0 4 4 4 0 SpoIIIAH-like protein TFIIA PF03153.13 CDI80322.1 - 7.9e-05 22.8 12.7 7.9e-05 22.8 12.7 2.4 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI80322.1 - 0.035 13.1 19.5 0.43 9.6 1.2 2.2 2 0 0 2 2 2 0 Solute carrier family 12 DUF2052 PF09747.9 CDI80322.1 - 0.31 11.1 25.6 1.4 9.0 11.4 2.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CCSAP PF15748.5 CDI80322.1 - 1.4 9.1 22.6 1.2 9.2 11.6 2.4 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF4199 PF13858.6 CDI80322.1 - 1.4 9.3 3.2 9.4 6.6 3.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) AAA_11 PF13086.6 CDI80322.1 - 1.9 8.2 21.3 3.2 7.5 9.0 2.3 2 0 0 2 2 2 0 AAA domain Suf PF05843.14 CDI80322.1 - 3 7.7 13.7 3.6 7.5 9.0 2.5 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 CDI80322.1 - 3.6 6.3 19.4 0.23 10.2 8.3 2.3 2 0 0 2 2 2 0 Presenilin Caldesmon PF02029.15 CDI80322.1 - 6.7 5.4 28.9 5.7 5.6 6.5 2.2 2 0 0 2 2 2 0 Caldesmon Wtap PF17098.5 CDI80323.1 - 0.004 17.1 0.4 0.004 17.1 0.4 2.0 1 1 1 2 2 2 1 WTAP/Mum2p family SPOUT_MTase PF02590.17 CDI80323.1 - 0.072 13.1 0.3 0.15 12.0 0.3 1.5 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase DUF2722 PF10846.8 CDI80325.1 - 0.00022 20.3 8.3 0.00022 20.3 8.3 3.9 3 1 1 4 4 3 1 Protein of unknown function (DUF2722) MFS_1 PF07690.16 CDI80325.1 - 0.0004 19.4 3.0 0.002 17.1 1.4 2.4 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CDI80325.1 - 0.0056 15.0 10.5 0.18 10.1 0.0 3.4 3 0 0 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family 7tm_1 PF00001.21 CDI80325.1 - 0.012 15.0 0.1 0.26 10.6 0.0 2.4 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Sugar_tr PF00083.24 CDI80325.1 - 0.013 14.4 3.4 0.016 14.1 0.1 2.3 2 0 0 2 2 2 0 Sugar (and other) transporter DUF2207 PF09972.9 CDI80325.1 - 0.019 13.7 0.4 2.3 6.9 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 CDI80325.1 - 0.13 12.6 0.0 0.13 12.6 0.0 5.2 5 1 0 5 5 4 0 Orf78 (ac78) Peroxin-13_N PF04088.13 CDI80325.1 - 0.57 10.5 20.6 1.3 9.3 0.4 4.3 5 0 0 5 5 5 0 Peroxin 13, N-terminal region SR-25 PF10500.9 CDI80325.1 - 0.69 9.5 46.2 0.098 12.3 13.6 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Eapp_C PF10238.9 CDI80325.1 - 1.3 9.1 27.5 0.14 12.2 2.5 3.9 4 0 0 4 4 4 0 E2F-associated phosphoprotein SURF2 PF05477.11 CDI80325.1 - 4.5 6.9 30.0 3.7 7.2 1.8 3.0 3 0 0 3 3 3 0 Surfeit locus protein 2 (SURF2) DUF2956 PF11169.8 CDI80325.1 - 8.5 6.6 37.6 0.82 9.9 3.3 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2956) UQ_con PF00179.26 CDI80327.1 - 1.8e-45 154.0 0.0 2.1e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI80327.1 - 0.0006 19.5 0.0 0.0014 18.3 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 CDI80327.1 - 0.001 18.7 0.0 0.0017 18.0 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 CDI80327.1 - 0.0075 16.5 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 RWD domain Val_tRNA-synt_C PF10458.9 CDI80327.1 - 0.11 12.8 2.2 0.27 11.5 2.2 1.6 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Glyco_transf_29 PF00777.18 CDI80327.1 - 0.18 11.2 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 29 (sialyltransferase) Shadoo PF14999.6 CDI80329.1 - 0.044 13.9 6.3 0.1 12.7 6.3 1.6 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective RskA PF10099.9 CDI80329.1 - 1.6 9.0 13.8 0.032 14.5 6.9 1.7 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DNA_ligase_A_M PF01068.21 CDI80332.1 - 1.7e-08 34.4 0.0 1.2e-06 28.3 0.0 2.7 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CDI80332.1 - 3.4e-08 34.0 1.6 4.9e-08 33.5 0.0 2.2 2 0 0 2 2 2 1 DNA ligase N terminus SR-25 PF10500.9 CDI80332.1 - 6.8e-05 22.6 5.5 6.8e-05 22.6 5.5 7.2 5 1 2 7 7 7 2 Nuclear RNA-splicing-associated protein Glutaredoxin PF00462.24 CDI80334.1 - 1.9e-06 28.0 0.2 0.0038 17.4 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin FapA PF03961.13 CDI80334.1 - 2.5e-06 26.4 9.1 2.8e-06 26.2 9.1 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A DASH_Spc19 PF08287.11 CDI80334.1 - 0.00016 21.6 30.8 0.00024 21.0 30.8 1.2 1 0 0 1 1 1 1 Spc19 DUF1640 PF07798.11 CDI80334.1 - 0.00035 20.7 9.5 0.00062 19.9 9.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) CRA PF06589.11 CDI80334.1 - 0.0014 18.7 0.4 0.0019 18.3 0.4 1.2 1 0 0 1 1 1 1 Circumsporozoite-related antigen (CRA) V_ATPase_I PF01496.19 CDI80334.1 - 0.006 14.6 11.4 0.0063 14.5 11.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family ZYG-11_interact PF05884.12 CDI80334.1 - 0.0095 15.4 8.8 0.013 15.0 8.8 1.2 1 0 0 1 1 1 1 Interactor of ZYG-11 FUSC PF04632.12 CDI80334.1 - 0.011 14.3 14.7 0.013 14.1 14.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ran-binding PF05508.11 CDI80334.1 - 0.012 14.7 12.6 0.014 14.4 11.6 1.5 1 1 0 1 1 1 0 RanGTP-binding protein DUF4407 PF14362.6 CDI80334.1 - 0.017 14.5 20.1 0.022 14.1 20.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pex14_N PF04695.13 CDI80334.1 - 0.018 15.7 19.4 0.029 15.0 19.4 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ALMT PF11744.8 CDI80334.1 - 0.021 13.7 6.8 0.022 13.6 6.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Exonuc_VII_L PF02601.15 CDI80334.1 - 0.021 14.4 22.9 0.028 14.0 22.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4471 PF14740.6 CDI80334.1 - 0.026 13.8 7.6 0.031 13.5 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) SpoIIP PF07454.11 CDI80334.1 - 0.032 13.7 10.0 0.032 13.7 10.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Vfa1 PF08432.10 CDI80334.1 - 0.039 14.3 15.7 0.051 13.9 15.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Methyltransf_12 PF08242.12 CDI80334.1 - 0.041 14.6 4.6 0.21 12.4 4.6 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CDI80334.1 - 0.042 14.6 1.5 0.15 12.8 0.2 2.0 1 1 1 2 2 2 0 Methyltransferase domain Utp11 PF03998.13 CDI80334.1 - 0.049 13.6 19.6 0.073 13.0 19.6 1.2 1 0 0 1 1 1 0 Utp11 protein AIP3 PF03915.13 CDI80334.1 - 0.058 12.5 22.7 0.078 12.1 22.7 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Atg14 PF10186.9 CDI80334.1 - 0.062 12.4 19.6 0.092 11.8 19.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RR_TM4-6 PF06459.12 CDI80334.1 - 0.07 13.0 13.3 0.086 12.7 13.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tho2 PF11262.8 CDI80334.1 - 0.076 12.2 10.0 0.088 12.0 10.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 MecA PF05389.12 CDI80334.1 - 0.077 12.6 10.0 0.1 12.2 10.0 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) SLC12 PF03522.15 CDI80334.1 - 0.081 11.9 11.6 0.088 11.8 11.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 UPF0565 PF10561.9 CDI80334.1 - 0.082 12.1 5.9 0.086 12.0 5.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Rtf2 PF04641.12 CDI80334.1 - 0.082 12.3 11.6 0.1 11.9 11.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger DDHD PF02862.17 CDI80334.1 - 0.083 13.0 8.6 0.091 12.9 8.6 1.2 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 CDI80334.1 - 0.084 11.9 9.9 0.1 11.6 9.9 1.1 1 0 0 1 1 1 0 CLN3 protein DUF1178 PF06676.11 CDI80334.1 - 0.1 13.0 11.0 0.17 12.2 11.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) DUF1840 PF08895.11 CDI80334.1 - 0.13 12.6 17.5 0.21 11.9 16.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) FAM76 PF16046.5 CDI80334.1 - 0.16 11.3 16.5 0.2 11.0 16.5 1.1 1 0 0 1 1 1 0 FAM76 protein Neur_chan_memb PF02932.16 CDI80334.1 - 0.17 11.9 7.9 0.21 11.6 7.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Prominin PF05478.11 CDI80334.1 - 0.19 9.6 16.1 0.22 9.4 16.1 1.0 1 0 0 1 1 1 0 Prominin eIF-3_zeta PF05091.12 CDI80334.1 - 0.2 10.6 16.7 0.24 10.3 16.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAT1 PF06391.13 CDI80334.1 - 0.2 11.5 25.1 0.36 10.6 25.1 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF2828 PF11443.8 CDI80334.1 - 0.22 9.6 13.6 0.26 9.3 13.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SID-1_RNA_chan PF13965.6 CDI80334.1 - 0.22 9.9 5.6 0.24 9.8 5.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CPSF100_C PF13299.6 CDI80334.1 - 0.24 11.6 10.8 0.31 11.2 10.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 CDI80334.1 - 0.27 11.0 7.2 0.34 10.6 7.2 1.1 1 0 0 1 1 1 0 Connexin Flagellar_rod PF05149.12 CDI80334.1 - 0.29 10.6 30.1 0.46 9.9 30.1 1.3 1 0 0 1 1 1 0 Paraflagellar rod protein MDM31_MDM32 PF08118.11 CDI80334.1 - 0.35 9.5 8.5 0.44 9.2 8.5 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Baculo_p24 PF05073.12 CDI80334.1 - 0.36 10.6 11.3 0.53 10.0 11.3 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein Folliculin PF11704.8 CDI80334.1 - 0.41 10.5 13.4 0.6 10.0 13.4 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF5094 PF17015.5 CDI80334.1 - 0.42 10.7 12.8 0.58 10.2 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) MDM10 PF12519.8 CDI80334.1 - 0.44 9.4 8.5 0.43 9.4 8.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Peptidase_S15 PF02129.18 CDI80334.1 - 0.58 9.7 9.9 0.76 9.3 9.9 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) LMBR1 PF04791.16 CDI80334.1 - 0.62 8.9 9.5 0.7 8.7 9.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Miga PF10265.9 CDI80334.1 - 0.67 8.9 11.6 0.78 8.6 11.6 1.1 1 0 0 1 1 1 0 Mitoguardin Peptidase_S64 PF08192.11 CDI80334.1 - 0.72 8.3 11.7 0.91 7.9 11.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ndc1_Nup PF09531.10 CDI80334.1 - 0.84 8.3 13.4 0.9 8.2 13.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4192 PF13830.6 CDI80334.1 - 0.86 9.6 7.3 1.1 9.2 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) CCDC-167 PF15188.6 CDI80334.1 - 0.87 10.0 14.4 0.29 11.5 11.8 1.5 2 0 0 2 2 1 0 Coiled-coil domain-containing protein 167 MMR1 PF08505.10 CDI80334.1 - 0.91 9.8 16.2 1.6 9.0 16.2 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PRKG1_interact PF15898.5 CDI80334.1 - 0.91 10.5 30.8 0.18 12.7 27.6 1.4 2 0 0 2 2 1 0 cGMP-dependent protein kinase interacting domain WDCP PF15390.6 CDI80334.1 - 0.92 7.8 14.9 1.1 7.5 14.9 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family AIF_C PF14721.6 CDI80334.1 - 0.95 9.8 7.2 1.5 9.2 7.2 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Sec62 PF03839.16 CDI80334.1 - 0.97 8.9 9.7 1.1 8.7 9.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 ABC2_membrane_2 PF12679.7 CDI80334.1 - 0.99 8.6 6.6 1.1 8.4 6.6 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein ECH_2 PF16113.5 CDI80334.1 - 1.1 8.7 8.5 1.2 8.5 8.5 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Het-C PF07217.11 CDI80334.1 - 1.1 7.8 7.9 1.2 7.5 7.9 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Membralin PF09746.9 CDI80334.1 - 1.4 7.9 7.1 1.4 7.9 7.1 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF4616 PF15394.6 CDI80334.1 - 1.5 7.7 10.1 1.6 7.6 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4616) PAT1 PF09770.9 CDI80334.1 - 1.5 7.0 29.0 1.8 6.7 29.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4228 PF14009.6 CDI80334.1 - 1.5 9.2 7.2 1.9 8.8 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Zip PF02535.22 CDI80334.1 - 1.5 7.9 2.8 1.5 8.0 2.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter XRN_M PF17846.1 CDI80334.1 - 1.6 7.6 10.9 1.9 7.3 10.9 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Presenilin PF01080.17 CDI80334.1 - 1.8 7.3 16.0 2 7.1 16.0 1.1 1 0 0 1 1 1 0 Presenilin 7tm_7 PF08395.12 CDI80334.1 - 1.9 7.6 14.9 2.6 7.1 14.9 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor Nup88 PF10168.9 CDI80334.1 - 1.9 6.2 22.8 2.2 6.0 22.8 1.1 1 0 0 1 1 1 0 Nuclear pore component FAM60A PF15396.6 CDI80334.1 - 2.1 8.3 9.7 2.6 8.0 9.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MMPL PF03176.15 CDI80334.1 - 2.2 7.1 9.2 2.6 6.9 9.2 1.2 1 0 0 1 1 1 0 MMPL family DUF87 PF01935.17 CDI80334.1 - 2.2 8.3 5.4 2.2 8.3 5.4 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain EIIBC-GUT_N PF03612.14 CDI80334.1 - 2.5 7.8 12.4 3.6 7.3 12.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus 5_nucleotid PF05761.14 CDI80334.1 - 2.7 6.8 15.3 3.6 6.4 15.3 1.1 1 0 0 1 1 1 0 5' nucleotidase family CCSAP PF15748.5 CDI80334.1 - 3.4 7.8 16.8 4.1 7.5 16.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated FAM176 PF14851.6 CDI80334.1 - 3.7 7.2 9.4 5.3 6.7 9.4 1.2 1 0 0 1 1 1 0 FAM176 family PepSY_TM PF03929.16 CDI80334.1 - 3.8 7.1 7.3 4.7 6.8 7.3 1.1 1 0 0 1 1 1 0 PepSY-associated TM region AAA_13 PF13166.6 CDI80334.1 - 4 5.9 18.6 5.1 5.6 18.6 1.1 1 0 0 1 1 1 0 AAA domain TERB2 PF15101.6 CDI80334.1 - 4.1 7.4 19.6 7.2 6.6 19.6 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Gastrin PF00918.17 CDI80334.1 - 4.1 8.4 14.9 7.1 7.6 14.9 1.4 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Band_3_cyto PF07565.13 CDI80334.1 - 4.5 7.0 14.0 5.8 6.6 14.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4746 PF15928.5 CDI80334.1 - 4.6 6.6 11.3 5.9 6.2 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CobT PF06213.12 CDI80334.1 - 4.6 6.6 21.9 6.8 6.0 21.9 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paramyxo_ncap PF00973.19 CDI80334.1 - 4.7 6.0 10.9 5.5 5.8 10.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2347 PF09804.9 CDI80334.1 - 4.7 6.7 9.0 5.9 6.4 9.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) CSG2 PF16965.5 CDI80334.1 - 4.8 6.0 7.4 5.9 5.7 7.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator OmpH PF03938.14 CDI80334.1 - 4.9 7.5 52.7 0.3 11.4 45.4 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Cellulose_synt PF03552.14 CDI80334.1 - 4.9 5.5 4.5 5.5 5.4 4.5 1.0 1 0 0 1 1 1 0 Cellulose synthase Ureide_permease PF07168.11 CDI80334.1 - 5.2 5.7 7.0 6.5 5.4 7.0 1.1 1 0 0 1 1 1 0 Ureide permease MCU PF04678.13 CDI80334.1 - 5.2 7.1 22.8 7.3e+02 0.1 22.8 2.2 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF3810 PF12725.7 CDI80334.1 - 5.4 6.3 6.7 6.7 6.0 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) FemAB PF02388.16 CDI80334.1 - 5.4 5.8 21.0 7.6 5.3 21.0 1.1 1 0 0 1 1 1 0 FemAB family CemA PF03040.14 CDI80334.1 - 6.2 6.7 8.8 8 6.3 8.8 1.2 1 0 0 1 1 1 0 CemA family Cons_hypoth95 PF03602.15 CDI80334.1 - 6.4 6.4 11.4 0.23 11.1 3.1 2.0 1 1 1 2 2 2 0 Conserved hypothetical protein 95 Gti1_Pac2 PF09729.9 CDI80334.1 - 6.6 6.8 11.2 9 6.3 11.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Ctr PF04145.15 CDI80334.1 - 6.9 7.3 8.2 8.9 6.9 8.2 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Folate_carrier PF01770.18 CDI80334.1 - 7.1 5.3 8.4 8.4 5.0 8.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Kei1 PF08552.11 CDI80334.1 - 8.6 6.2 6.4 11 5.8 6.4 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 LptF_LptG PF03739.14 CDI80334.1 - 9.2 5.0 7.9 12 4.6 7.9 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG DUF3381 PF11861.8 CDI80334.1 - 9.5 6.0 26.5 14 5.4 26.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) PepSY_TM_like_2 PF16357.5 CDI80334.1 - 9.5 6.1 11.1 12 5.8 11.1 1.4 1 0 0 1 1 1 0 Putative PepSY_TM-like ARTD15_N PF18084.1 CDI80334.1 - 9.8 6.5 10.0 1.1 9.5 1.8 2.3 1 1 1 2 2 2 0 ARTD15 N-terminal domain DUF2722 PF10846.8 CDI80336.1 - 0.01 14.8 14.9 0.01 14.8 14.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SOBP PF15279.6 CDI80336.1 - 0.095 13.3 17.0 0.11 13.1 17.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3464 PF11947.8 CDI80336.1 - 0.12 12.1 13.1 0.36 10.6 13.1 1.9 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 VirE PF05272.11 CDI80336.1 - 0.13 11.9 1.8 0.12 12.0 0.8 1.4 1 1 0 1 1 1 0 Virulence-associated protein E DUF4160 PF13711.6 CDI80336.1 - 0.17 12.3 0.9 0.4 11.0 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) PPP4R2 PF09184.11 CDI80336.1 - 0.22 11.1 11.1 0.25 10.9 11.1 1.2 1 0 0 1 1 1 0 PPP4R2 Presenilin PF01080.17 CDI80336.1 - 0.27 9.9 14.6 0.29 9.9 14.6 1.1 1 0 0 1 1 1 0 Presenilin DUF3391 PF11871.8 CDI80336.1 - 0.48 11.0 10.2 0.9 10.1 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) PepSY_TM PF03929.16 CDI80336.1 - 0.92 9.1 2.8 1.2 8.8 2.8 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Hid1 PF12722.7 CDI80336.1 - 4.9 5.2 14.6 5.3 5.0 14.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Chorion_2 PF03964.15 CDI80336.1 - 6.1 7.8 15.6 13 6.7 15.5 1.7 1 1 0 1 1 1 0 Chorion family 2 Ndc1_Nup PF09531.10 CDI80336.1 - 6.1 5.4 16.0 6.9 5.2 16.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 CDI80336.1 - 7.3 6.5 29.4 12 5.8 29.4 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CDI80336.1 - 7.7 3.5 16.0 8.1 3.4 16.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NPR1_interact PF15699.5 CDI80336.1 - 9 7.0 17.0 1.1 10.0 12.4 1.8 2 1 0 2 2 2 0 NPR1 interacting NAD_binding_8 PF13450.6 CDI80338.1 - 1.4e-07 31.6 8.9 0.00051 20.2 0.0 3.8 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain LCIB_C_CA PF18599.1 CDI80338.1 - 0.055 12.8 1.5 0.15 11.4 1.5 1.7 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases DUF3740 PF12548.8 CDI80338.1 - 3.8 8.0 9.6 0.24 11.8 3.7 2.1 2 0 0 2 2 2 0 Sulfatase protein RRM_1 PF00076.22 CDI80339.1 - 3.4e-21 74.8 0.0 6.2e-12 45.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI80339.1 - 4.2e-11 42.5 0.0 2.8e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 CDI80339.1 - 1.6e-06 27.7 0.0 0.034 13.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC_CDC26 PF10471.9 CDI80339.1 - 0.023 15.5 6.2 0.052 14.4 6.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Nup35_RRM_2 PF14605.6 CDI80339.1 - 0.032 14.2 0.2 6.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Suf PF05843.14 CDI80339.1 - 0.038 14.0 1.6 0.055 13.4 1.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Limkain-b1 PF11608.8 CDI80339.1 - 0.054 13.6 0.0 0.57 10.3 0.0 2.4 2 1 0 2 2 2 0 Limkain b1 DUF4523 PF15023.6 CDI80339.1 - 0.13 12.0 0.0 0.37 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) TFIIA PF03153.13 CDI80339.1 - 0.22 11.5 9.4 0.28 11.1 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NINJA_B PF16136.5 CDI80339.1 - 0.27 11.6 3.3 0.53 10.7 3.3 1.4 1 0 0 1 1 1 0 Putative nuclear localisation signal Pkinase PF00069.25 CDI80341.1 - 2.5e-50 171.3 0.0 3.5e-50 170.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80341.1 - 5.1e-22 78.4 0.0 7.3e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI80341.1 - 1.9e-05 24.1 0.0 3.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 CDI80341.1 - 0.084 13.6 0.0 0.17 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain VPR PF00522.18 CDI80341.1 - 0.094 12.8 0.0 0.71 9.9 0.0 2.1 2 0 0 2 2 2 0 VPR/VPX protein Pkinase PF00069.25 CDI80343.1 - 1.2e-43 149.4 0.0 1.7e-28 99.7 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80343.1 - 6.6e-24 84.6 0.0 1.9e-16 60.1 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase DUF3818 PF12825.7 CDI80345.1 - 0.025 13.6 0.4 0.052 12.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) PUF PF00806.19 CDI80345.1 - 0.04 13.6 0.1 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat SRC-1 PF08832.10 CDI80345.1 - 8 7.6 8.9 0.69 11.0 1.6 2.7 2 1 0 2 2 2 0 Steroid receptor coactivator Vps51 PF08700.11 CDI80346.1 - 1.3e-17 63.7 0.6 1.3e-17 63.7 0.6 2.9 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 CDI80346.1 - 3.2e-06 27.2 0.1 3.2e-06 27.2 0.1 3.3 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Dor1 PF04124.12 CDI80346.1 - 0.0003 19.6 5.7 0.00062 18.5 5.7 1.5 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 CDI80346.1 - 0.0038 17.4 3.5 0.0038 17.4 3.5 2.3 2 0 0 2 2 2 1 Golgi transport complex subunit 5 DUF948 PF06103.11 CDI80346.1 - 0.022 15.0 1.6 0.41 10.9 0.5 3.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec5 PF15469.6 CDI80346.1 - 3.8 7.3 14.9 0.0088 15.9 3.8 2.4 3 1 0 3 3 3 0 Exocyst complex component Sec5 ABC_tran PF00005.27 CDI80347.1 - 2.9e-14 53.7 0.8 9.9e-10 39.1 0.0 3.9 3 1 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 CDI80347.1 - 1.8e-13 50.8 3.1 9.4e-09 35.3 0.2 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_16 PF13191.6 CDI80347.1 - 0.0018 18.7 0.1 0.0018 18.7 0.1 3.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 CDI80347.1 - 0.002 17.8 0.1 0.006 16.3 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain rRNA_processing PF08524.11 CDI80347.1 - 0.0035 17.4 8.8 0.0035 17.4 8.8 3.9 4 1 0 5 5 3 1 rRNA processing T2SSE PF00437.20 CDI80347.1 - 0.0084 15.2 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.15 CDI80347.1 - 0.016 15.1 0.2 0.042 13.8 0.2 1.7 1 0 0 1 1 1 0 NTPase cobW PF02492.19 CDI80347.1 - 0.017 14.7 0.1 0.039 13.5 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 CDI80347.1 - 0.023 15.0 0.2 0.066 13.5 0.2 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDI80347.1 - 0.025 15.0 0.0 0.068 13.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDI80347.1 - 0.031 13.9 0.1 0.081 12.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDI80347.1 - 0.038 13.3 0.1 0.099 12.0 0.1 1.6 1 0 0 1 1 1 0 KaiC AAA_11 PF13086.6 CDI80347.1 - 0.057 13.2 0.0 0.057 13.2 0.0 3.8 4 0 0 4 4 3 0 AAA domain AAA_22 PF13401.6 CDI80347.1 - 0.12 12.6 3.3 0.12 12.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDI80347.1 - 0.16 12.5 0.1 0.16 12.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain GvpD PF07088.11 CDI80347.1 - 0.22 10.1 0.0 0.34 9.5 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein NACHT PF05729.12 CDI80347.1 - 0.22 11.4 1.3 0.65 9.9 0.1 2.2 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 CDI80347.1 - 0.52 10.5 0.0 0.52 10.5 0.0 2.9 4 0 0 4 4 3 0 AAA domain Viral_helicase1 PF01443.18 CDI80347.1 - 0.68 9.6 2.9 0.42 10.3 0.1 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 CDI80347.1 - 3.4 6.5 4.6 0.58 9.1 0.1 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 CDI80348.1 - 4.6e-42 143.6 0.0 8.7e-42 142.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI80348.1 - 1.7e-12 46.9 0.4 3.7e-12 45.9 0.4 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDI80348.1 - 2.4e-08 33.8 0.1 5e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 CDI80348.1 - 2.7e-07 30.9 0.0 8.5e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDI80348.1 - 3e-07 31.0 0.2 0.00014 22.3 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CDI80348.1 - 5.5e-06 26.4 0.1 7.8e-05 22.7 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDI80348.1 - 1.2e-05 25.1 0.0 3.1e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDI80348.1 - 0.00015 22.0 0.4 0.024 14.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_24 PF13479.6 CDI80348.1 - 0.0007 19.4 0.1 0.013 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CDI80348.1 - 0.00091 19.0 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 CDI80348.1 - 0.0011 18.5 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 CDI80348.1 - 0.0015 18.3 0.1 0.0064 16.2 0.0 2.0 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.6 CDI80348.1 - 0.0016 19.0 0.3 0.0086 16.6 0.0 2.4 2 2 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDI80348.1 - 0.0017 17.7 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 CDI80348.1 - 0.0025 18.2 0.0 0.0054 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 CDI80348.1 - 0.0039 16.6 0.1 0.0073 15.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CDI80348.1 - 0.0063 16.5 0.1 0.016 15.2 0.0 1.7 2 0 0 2 2 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CDI80348.1 - 0.0082 16.3 0.0 0.053 13.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 CDI80348.1 - 0.0087 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_3 PF07726.11 CDI80348.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 CDI80348.1 - 0.011 15.2 0.1 0.026 14.0 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Prot_ATP_OB_N PF17758.1 CDI80348.1 - 0.012 15.2 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_14 PF13173.6 CDI80348.1 - 0.018 15.1 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDI80348.1 - 0.022 15.0 0.1 0.067 13.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CDI80348.1 - 0.029 13.4 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 CDI80348.1 - 0.031 13.6 0.0 0.085 12.2 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.6 CDI80348.1 - 0.037 13.6 0.1 0.11 12.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CDI80348.1 - 0.071 12.9 2.1 0.19 11.5 0.0 2.3 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.12 CDI80348.1 - 0.099 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 CDI80348.1 - 0.1 12.5 0.1 0.53 10.2 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Sigma54_activ_2 PF14532.6 CDI80348.1 - 0.15 12.2 0.0 0.56 10.3 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain UMP1 PF05348.11 CDI80349.1 - 1.3e-13 51.2 0.0 1.7e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Aldedh PF00171.22 CDI80350.1 - 0.0024 16.4 0.4 0.77 8.2 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family WHIM1 PF15612.6 CDI80350.1 - 0.026 14.1 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 ODV-E18 PF10717.9 CDI80352.1 - 0.0015 18.4 0.2 0.002 17.9 0.2 1.2 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 Rdx PF10262.9 CDI80352.1 - 0.0028 17.8 0.0 0.0029 17.7 0.0 1.2 1 0 0 1 1 1 1 Rdx family DUF1631 PF07793.11 CDI80352.1 - 0.056 11.9 2.4 0.059 11.8 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Lin-8 PF03353.15 CDI80353.1 - 0.0035 17.0 26.4 0.0073 15.9 26.4 1.5 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI80353.1 - 0.028 12.7 20.7 0.048 12.0 20.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 CDI80353.1 - 0.055 11.6 21.8 0.089 10.9 21.8 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI80353.1 - 0.36 9.6 38.2 0.94 8.2 35.1 2.2 2 0 0 2 2 2 0 Presenilin Mem_trans PF03547.18 CDI80353.1 - 0.47 8.8 2.3 0.65 8.3 2.3 1.2 1 0 0 1 1 1 0 Membrane transport protein Caldesmon PF02029.15 CDI80353.1 - 1.5 7.5 36.9 0.015 14.1 28.9 1.6 2 0 0 2 2 2 0 Caldesmon GREB1 PF15782.5 CDI80353.1 - 2.3 5.3 26.4 3.7 4.5 26.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S64 PF08192.11 CDI80353.1 - 5.4 5.4 20.2 8 4.8 20.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 BORG_CEP PF14957.6 CDI80353.1 - 8.9 7.5 22.1 0.98 10.6 13.9 3.4 3 0 0 3 3 3 0 Cdc42 effector Porph_ging PF09697.10 CDI80357.1 - 0.008 16.7 1.8 0.0096 16.4 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (Porph_ging) Rsc14 PF08586.10 CDI80357.1 - 0.036 14.8 2.8 0.042 14.6 2.8 1.1 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit ArAE_2_N PF10337.9 CDI80357.1 - 0.11 11.6 1.7 0.11 11.5 1.7 1.0 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal DUF2722 PF10846.8 CDI80357.1 - 0.19 10.7 13.3 0.19 10.7 13.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TMEM208_SND2 PF05620.11 CDI80357.1 - 0.33 10.7 3.1 0.39 10.5 3.1 1.1 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Spt20 PF12090.8 CDI80357.1 - 0.37 10.4 15.4 0.38 10.3 15.4 1.0 1 0 0 1 1 1 0 Spt20 family DUF3464 PF11947.8 CDI80357.1 - 0.55 10.0 4.4 0.59 9.9 4.4 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 CDI80357.1 - 1.4 7.6 4.0 1.5 7.5 4.0 1.0 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDI80357.1 - 1.6 7.8 8.8 1.6 7.7 8.8 1.0 1 0 0 1 1 1 0 Drosophila roughex protein Androgen_recep PF02166.16 CDI80357.1 - 2.4 6.9 10.9 2.2 7.0 10.9 1.0 1 0 0 1 1 1 0 Androgen receptor Lactamase_B_6 PF16661.5 CDI80358.1 - 1.7e-10 40.7 0.0 0.013 15.0 0.0 3.4 3 0 0 3 3 3 3 Metallo-beta-lactamase superfamily domain SR-25 PF10500.9 CDI80358.1 - 0.12 11.9 64.1 0.96 9.0 8.1 5.4 5 0 0 5 5 5 0 Nuclear RNA-splicing-associated protein Antimicrobial_1 PF08018.11 CDI80358.1 - 0.26 11.5 0.0 0.26 11.5 0.0 4.6 5 0 0 5 5 5 0 Frog antimicrobial peptide Nop53 PF07767.11 CDI80358.1 - 6.5 6.0 18.3 0.44 9.9 12.0 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) MMR1 PF08505.10 CDI80359.1 - 0.004 17.5 17.8 0.004 17.5 17.8 2.1 2 0 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein EIIBC-GUT_N PF03612.14 CDI80359.1 - 0.011 15.4 4.9 0.011 15.4 4.9 3.2 2 1 0 2 2 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5519 PF17648.1 CDI80359.1 - 0.027 14.3 1.7 0.027 14.3 1.7 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5519) Med15 PF09606.10 CDI80359.1 - 0.045 12.4 60.7 0.018 13.8 33.6 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Cwf_Cwc_15 PF04889.12 CDI80359.1 - 0.069 12.9 22.7 0.036 13.8 11.5 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SLC12 PF03522.15 CDI80359.1 - 0.074 12.1 26.1 0.063 12.3 14.8 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Vfa1 PF08432.10 CDI80359.1 - 0.096 13.0 22.5 1.4 9.2 13.6 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Lin-8 PF03353.15 CDI80359.1 - 0.11 12.0 35.2 0.17 11.4 20.5 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI80359.1 - 0.17 10.1 19.0 0.28 9.4 10.8 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF5523 PF17661.1 CDI80359.1 - 0.17 11.5 26.1 0.6 9.8 12.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) TCP PF03634.13 CDI80359.1 - 0.31 11.6 28.2 0.048 14.2 0.8 2.6 2 2 0 2 2 2 0 TCP family transcription factor SOBP PF15279.6 CDI80359.1 - 0.38 11.3 27.8 0.33 11.5 18.3 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein DUF3807 PF12720.7 CDI80359.1 - 0.56 10.5 34.3 0.2 11.9 16.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF3807) DUF4471 PF14740.6 CDI80359.1 - 0.66 9.1 15.4 0.4 9.9 5.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Rtf2 PF04641.12 CDI80359.1 - 0.72 9.2 21.0 3.5 6.9 0.4 2.4 2 0 0 2 2 2 0 Rtf2 RING-finger RR_TM4-6 PF06459.12 CDI80359.1 - 0.78 9.5 28.1 1.7 8.4 15.4 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Tyrosinase PF00264.20 CDI80359.1 - 0.91 9.8 9.1 4.4 7.5 3.5 2.3 2 0 0 2 2 2 0 Common central domain of tyrosinase DUF2126 PF09899.9 CDI80359.1 - 1.4 6.9 15.0 0.67 8.0 5.8 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) DUF1645 PF07816.11 CDI80359.1 - 1.4 9.5 28.8 0.8 10.3 5.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1645) DUF4778 PF16008.5 CDI80359.1 - 1.4 8.9 23.2 0.24 11.4 14.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) PNISR PF15996.5 CDI80359.1 - 1.6 8.9 34.4 2 8.7 19.8 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR FTO_NTD PF12933.7 CDI80359.1 - 2.2 7.5 22.4 0.48 9.6 11.3 2.5 2 1 1 3 3 3 0 FTO catalytic domain MID_MedPIWI PF18296.1 CDI80359.1 - 2.4 7.9 32.5 0.03 14.1 9.3 2.1 1 1 1 2 2 2 0 MID domain of medPIWI SID-1_RNA_chan PF13965.6 CDI80359.1 - 2.9 6.2 12.2 2.2 6.6 6.1 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Peptidase_U57 PF05582.12 CDI80359.1 - 5.1 6.3 17.6 0.66 9.2 6.6 2.3 2 0 0 2 2 2 0 YabG peptidase U57 Afaf PF15339.6 CDI80359.1 - 6.2 6.5 8.8 0.73 9.5 1.5 2.3 2 1 0 2 2 2 0 Acrosome formation-associated factor tRNA-synt_1 PF00133.22 CDI80360.1 - 2e-27 95.7 43.6 5.7e-17 61.2 0.0 6.9 6 1 1 7 7 7 5 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDI80360.1 - 0.0071 16.3 2.2 0.079 12.9 0.0 3.4 3 1 0 3 3 3 1 Anticodon-binding domain of tRNA RskA PF10099.9 CDI80360.1 - 0.012 15.9 0.4 0.012 15.9 0.4 15.6 6 5 5 12 12 12 0 Anti-sigma-K factor rskA Activator_LAG-3 PF11498.8 CDI80361.1 - 0.0034 16.4 28.2 0.0034 16.4 28.2 3.9 2 1 0 3 3 3 1 Transcriptional activator LAG-3 Sin_N PF04801.13 CDI80361.1 - 0.0051 16.1 1.7 0.0051 16.1 1.7 3.3 2 1 1 3 3 3 1 Sin-like protein conserved region Phostensin_N PF13916.6 CDI80361.1 - 0.079 13.3 0.3 0.079 13.3 0.3 5.4 4 2 1 5 5 5 0 PP1-regulatory protein, Phostensin N-terminal SMC_hinge PF06470.13 CDI80362.1 - 8.4e-13 48.7 0.0 8.4e-13 48.7 0.0 3.9 4 0 0 4 4 4 1 SMC proteins Flexible Hinge Domain Ribosomal_60s PF00428.19 CDI80362.1 - 0.0029 18.1 11.9 0.0029 18.1 11.9 7.0 5 2 2 7 7 7 1 60s Acidic ribosomal protein SMC_N PF02463.19 CDI80362.1 - 0.076 12.4 0.1 0.076 12.4 0.1 4.9 2 2 2 4 4 4 0 RecF/RecN/SMC N terminal domain SUIM_assoc PF16619.5 CDI80366.1 - 9.4e-06 25.6 0.0 9.4e-06 25.6 0.0 4.5 3 2 2 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 Macoilin PF09726.9 CDI80366.1 - 0.1 11.1 25.1 0.054 12.1 22.7 1.7 2 0 0 2 2 2 0 Macoilin family Ureide_permease PF07168.11 CDI80366.1 - 0.11 11.2 0.1 0.22 10.3 0.1 1.5 1 0 0 1 1 1 0 Ureide permease DUF4366 PF14283.6 CDI80366.1 - 0.32 11.0 4.9 1.4 9.0 5.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Spc7_N PF15402.6 CDI80366.1 - 0.35 9.1 31.9 0.49 8.6 31.9 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 SPX PF03105.19 CDI80366.1 - 5.8 6.7 27.9 8.3 6.2 27.9 1.3 1 0 0 1 1 1 0 SPX domain Helicase_C PF00271.31 CDI80367.1 - 0.00042 20.6 0.7 0.016 15.5 0.0 4.1 3 1 0 3 3 3 1 Helicase conserved C-terminal domain SUIM_assoc PF16619.5 CDI80367.1 - 0.015 15.3 0.2 0.015 15.3 0.2 16.7 10 5 4 14 14 14 0 Unstructured region C-term to UIM in Ataxin3 DUF2919 PF11143.8 CDI80367.1 - 0.17 12.2 0.1 0.49 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) Thymidylat_synt PF00303.19 CDI80368.1 - 7.3e-44 149.9 4.6 2.9e-40 138.1 0.0 2.8 2 1 1 3 3 3 2 Thymidylate synthase DHFR_1 PF00186.19 CDI80368.1 - 2.8e-06 27.1 0.4 2.8e-06 27.1 0.4 2.0 2 1 1 3 3 3 1 Dihydrofolate reductase Sin_N PF04801.13 CDI80368.1 - 2.3e-05 23.8 20.7 3.8e-05 23.1 20.7 1.3 1 0 0 1 1 1 1 Sin-like protein conserved region SLC12 PF03522.15 CDI80368.1 - 0.00082 18.5 12.1 0.0011 18.1 12.1 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI80368.1 - 0.025 13.3 11.5 0.031 13.0 11.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ATG22 PF11700.8 CDI80368.1 - 0.052 12.2 0.2 0.052 12.2 0.2 1.9 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like Ribosomal_60s PF00428.19 CDI80368.1 - 1.3 9.7 13.2 3.5 8.3 13.2 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Peptidase_S64 PF08192.11 CDI80368.1 - 1.8 7.0 15.3 2.4 6.5 15.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 Peptidase_S49_N PF08496.10 CDI80368.1 - 4.9 7.2 17.5 8.5 6.4 1.4 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Phage_holin_3_6 PF07332.11 CDI80370.1 - 5 7.2 9.1 1 9.4 0.4 2.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Folliculin PF11704.8 CDI80371.1 - 0.19 11.6 2.5 0.25 11.2 2.5 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport VitK2_biosynth PF02621.14 CDI80371.1 - 0.24 10.9 2.8 0.3 10.5 2.8 1.1 1 0 0 1 1 1 0 Menaquinone biosynthesis RRF PF01765.19 CDI80371.1 - 0.46 10.4 9.3 0.57 10.1 9.3 1.2 1 0 0 1 1 1 0 Ribosome recycling factor Ntox15 PF15604.6 CDI80371.1 - 0.5 10.5 8.2 0.67 10.1 8.2 1.3 1 0 0 1 1 1 0 Novel toxin 15 Methyltr_RsmB-F PF01189.17 CDI80372.1 - 4e-18 65.8 0.0 1e-09 38.3 0.0 3.0 3 0 0 3 3 3 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 CDI80372.1 - 0.013 15.6 0.0 0.057 13.5 0.0 1.9 1 1 0 1 1 1 0 FtsJ-like methyltransferase Prismane PF03063.20 CDI80372.1 - 0.13 11.0 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family BTB_2 PF02214.22 CDI80374.1 - 1.7e-13 50.7 0.0 4.2e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain SET PF00856.28 CDI80374.1 - 0.037 14.4 0.3 0.073 13.5 0.3 1.4 1 0 0 1 1 1 0 SET domain WRNPLPNID PF15017.6 CDI80374.1 - 0.59 11.1 4.1 2.3 9.2 1.8 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DUF2477 PF10631.9 CDI80374.1 - 4.6 7.9 19.4 0.7 10.6 15.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) SUV3_C PF12513.8 CDI80375.1 - 2.1e-12 46.8 0.0 4.9e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 CDI80375.1 - 7.9e-06 25.6 0.3 1.7e-05 24.6 0.3 1.6 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 CDI80375.1 - 9.2e-05 22.8 0.0 0.00038 20.8 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain PNTB PF02233.16 CDI80375.1 - 5.1 5.9 5.5 11 4.9 5.5 1.4 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit FAD_binding_3 PF01494.19 CDI80376.1 - 9.2e-40 136.9 2.0 3.9e-19 69.1 0.0 4.4 5 0 0 5 5 5 3 FAD binding domain Pyr_redox_3 PF13738.6 CDI80376.1 - 0.0015 17.8 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDI80376.1 - 0.0026 17.4 0.0 0.0052 16.4 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDI80376.1 - 0.0043 17.3 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDI80376.1 - 0.087 12.0 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDI80376.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Ribosomal_L12 PF00542.19 CDI80377.1 - 2.3e-19 69.5 1.4 2.3e-19 69.5 1.4 1.5 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CDI80377.1 - 1.7e-13 50.1 0.3 1.7e-13 50.1 0.3 2.4 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain IBN_N PF03810.19 CDI80379.1 - 3.4e-06 26.9 0.6 1.2e-05 25.1 0.1 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3201 PF11447.8 CDI80379.1 - 0.041 13.4 0.0 0.099 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) RPN6_N PF18055.1 CDI80379.1 - 0.057 13.8 0.2 0.23 11.8 0.1 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain Peptidase_M99_m PF17130.4 CDI80379.1 - 0.08 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 beta-barrel domain of carboxypeptidase M99 HTH_1 PF00126.27 CDI80380.1 - 0.11 12.4 1.3 0.16 11.9 0.4 1.8 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Baculo_gp41 PF04700.12 CDI80380.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region HSP90 PF00183.18 CDI80382.1 - 2.4e-19 69.7 0.5 2.9e-19 69.4 0.5 1.0 1 0 0 1 1 1 1 Hsp90 protein Sugar-bind PF04198.13 CDI80383.1 - 0.02 14.0 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 Putative sugar-binding domain ParD PF09386.10 CDI80383.1 - 0.084 13.3 0.1 0.12 12.8 0.1 1.3 1 0 0 1 1 1 0 Antitoxin ParD Connexin PF00029.19 CDI80384.1 - 0.0033 17.2 5.2 0.019 14.7 2.7 2.1 2 0 0 2 2 2 1 Connexin FmiP_Thoc5 PF09766.9 CDI80384.1 - 0.0034 16.7 5.0 0.0034 16.7 5.0 2.1 2 0 0 2 2 2 1 Fms-interacting protein/Thoc5 Mito_carr PF00153.27 CDI80384.1 - 0.0039 17.1 0.1 1.2 9.1 0.0 3.2 2 0 0 2 2 2 1 Mitochondrial carrier protein DUF3464 PF11947.8 CDI80384.1 - 0.0043 16.8 2.7 0.0043 16.8 2.7 2.3 2 0 0 2 2 2 1 Photosynthesis affected mutant 68 Spt20 PF12090.8 CDI80384.1 - 0.0052 16.4 57.0 0.006 16.2 7.0 2.2 2 0 0 2 2 2 1 Spt20 family CDC45 PF02724.14 CDI80384.1 - 0.0079 14.5 1.1 0.0079 14.5 1.1 2.1 2 0 0 2 2 2 1 CDC45-like protein RNA_pol_Rpc4 PF05132.14 CDI80384.1 - 0.0087 16.5 1.6 0.0087 16.5 1.6 2.5 2 1 0 2 2 2 1 RNA polymerase III RPC4 Ureide_permease PF07168.11 CDI80384.1 - 0.021 13.6 0.3 0.021 13.6 0.3 2.1 2 0 0 2 2 2 0 Ureide permease Neur_chan_memb PF02932.16 CDI80384.1 - 0.023 14.8 1.4 0.023 14.8 1.4 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.13 CDI80384.1 - 0.03 15.0 14.0 0.03 15.0 14.0 2.7 2 1 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 CDI80384.1 - 0.058 12.6 0.1 0.058 12.6 0.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4471 PF14740.6 CDI80384.1 - 0.12 11.6 8.2 0.14 11.4 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) TRAP_alpha PF03896.16 CDI80384.1 - 0.32 10.2 7.4 0.94 8.6 2.5 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Otopetrin PF03189.13 CDI80384.1 - 0.37 9.6 9.4 0.67 8.7 1.4 2.1 2 0 0 2 2 2 0 Otopetrin Methyltransf_32 PF13679.6 CDI80384.1 - 0.42 10.6 11.3 3.3 7.7 5.3 2.2 2 0 0 2 2 2 0 Methyltransferase domain TT_ORF1 PF02956.14 CDI80384.1 - 0.71 8.5 15.1 0.058 12.1 4.0 2.0 2 0 0 2 2 2 0 TT viral orf 1 RPA43_OB PF17875.1 CDI80384.1 - 0.78 10.4 11.4 0.23 12.1 5.0 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF913 PF06025.12 CDI80384.1 - 0.98 8.3 15.6 0.089 11.8 2.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) AAR2 PF05282.11 CDI80384.1 - 1.2 8.5 16.5 0.76 9.1 2.4 2.3 2 0 0 2 2 2 0 AAR2 protein Peptidase_S49_N PF08496.10 CDI80384.1 - 1.2 9.2 8.6 2.3 8.3 8.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SpoIIP PF07454.11 CDI80384.1 - 2 7.8 25.3 0.33 10.4 13.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SID-1_RNA_chan PF13965.6 CDI80384.1 - 2.1 6.7 9.7 0.17 10.3 0.1 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 GBP_C PF02841.14 CDI80384.1 - 2.3 7.6 22.6 4.1 6.7 22.6 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain GvpL_GvpF PF06386.11 CDI80384.1 - 2.6 7.9 9.9 3.7 7.4 9.9 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Tim54 PF11711.8 CDI80384.1 - 3.8 6.2 17.8 2.6 6.8 10.8 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF3405 PF11885.8 CDI80384.1 - 4.8 5.7 12.3 0.2 10.2 3.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) SCAI PF12070.8 CDI80384.1 - 5.1 5.8 13.7 0.11 11.4 0.7 2.3 2 0 0 2 2 2 0 Protein SCAI Eapp_C PF10238.9 CDI80384.1 - 6 6.9 21.3 0.033 14.3 5.4 2.4 2 1 0 2 2 2 0 E2F-associated phosphoprotein SOG2 PF10428.9 CDI80384.1 - 6.8 5.8 36.4 3.6 6.7 3.5 2.0 2 0 0 2 2 2 0 RAM signalling pathway protein Spt20 PF12090.8 CDI80386.1 - 0.00082 19.0 12.7 0.00082 19.0 12.7 3.4 3 0 0 3 3 3 2 Spt20 family RskA PF10099.9 CDI80386.1 - 0.021 15.1 29.8 0.018 15.4 4.7 4.6 4 1 0 4 4 4 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI80386.1 - 0.092 12.7 39.1 0.29 11.1 6.5 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Piezo_RRas_bdg PF12166.8 CDI80387.1 - 0.0031 16.9 0.0 0.11 11.7 0.0 2.0 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain DUF4199 PF13858.6 CDI80387.1 - 0.083 13.3 0.2 0.15 12.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) RskA PF10099.9 CDI80387.1 - 0.28 11.5 5.3 0.97 9.7 1.4 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TMEM132D_C PF15706.5 CDI80387.1 - 0.28 11.0 1.5 19 5.1 0.2 2.5 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF3446 PF11928.8 CDI80387.1 - 2.4 8.5 9.4 0.55 10.6 5.5 1.8 2 0 0 2 2 2 0 Early growth response N-terminal domain AlaDh_PNT_C PF01262.21 CDI80388.1 - 1.5e-38 132.2 0.3 4.7e-38 130.6 0.3 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDI80388.1 - 1.5e-22 80.4 0.1 4.2e-22 78.9 0.1 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 CDI80388.1 - 6.9e-07 28.8 0.1 2.4e-06 27.0 0.1 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CDI80388.1 - 5.4e-06 26.5 0.1 2.1e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CDI80388.1 - 0.00019 20.8 0.1 0.00039 19.8 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDI80388.1 - 0.00026 19.8 0.0 0.00026 19.8 0.0 2.2 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 CDI80388.1 - 0.00028 20.3 0.1 0.0026 17.1 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 CDI80388.1 - 0.00029 20.8 0.0 0.00082 19.3 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CDI80388.1 - 0.0011 19.2 0.3 0.0032 17.7 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDI80388.1 - 0.0012 19.2 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CDI80388.1 - 0.0025 17.1 0.5 0.036 13.3 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase MTS PF05175.14 CDI80388.1 - 0.0043 16.6 0.1 0.011 15.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Pyr_redox PF00070.27 CDI80388.1 - 0.0045 17.5 0.1 0.026 15.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 CDI80388.1 - 0.013 15.1 0.1 0.11 12.1 0.0 2.6 2 1 2 4 4 4 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 CDI80388.1 - 0.013 16.2 0.1 0.11 13.2 0.0 2.6 3 1 0 3 3 2 0 Methyltransferase domain FAD_oxidored PF12831.7 CDI80388.1 - 0.014 14.8 1.0 0.014 14.8 1.0 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDI80388.1 - 0.015 14.4 0.1 0.024 13.7 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 CDI80388.1 - 0.015 15.5 0.1 0.089 13.1 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_8 PF13450.6 CDI80388.1 - 0.028 14.7 0.1 0.073 13.3 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain XdhC_C PF13478.6 CDI80388.1 - 0.056 14.0 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain DUF779 PF05610.11 CDI80388.1 - 0.091 13.0 0.0 0.8 10.0 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF779) MFS_1 PF07690.16 CDI80389.1 - 5.7e-17 61.7 39.0 8.8e-09 34.7 14.2 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 CDI80390.1 - 4.5e-82 275.4 0.0 6.7e-82 274.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80390.1 - 9.3e-44 149.6 0.0 7.1e-43 146.8 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI80390.1 - 1.7e-28 96.0 9.2 3.5e-07 29.3 0.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDI80390.1 - 5.5e-24 84.4 6.1 1.6e-11 44.5 0.2 2.9 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI80390.1 - 1.1e-23 81.1 4.1 1.5e-05 24.5 0.0 5.1 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CDI80390.1 - 4.7e-20 70.1 6.8 6.6e-06 25.4 0.4 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CDI80390.1 - 5.2e-13 48.6 12.3 0.0028 17.5 2.0 4.7 4 1 1 5 5 5 4 EF-hand domain pair Kinase-like PF14531.6 CDI80390.1 - 7.4e-07 28.8 0.0 4.7e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Kinase-like SPARC_Ca_bdg PF10591.9 CDI80390.1 - 9.7e-07 29.1 2.6 0.0048 17.2 0.4 3.1 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDI80390.1 - 8e-06 25.8 5.9 0.00062 19.7 1.1 3.7 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand Pkinase_fungal PF17667.1 CDI80390.1 - 0.00012 21.0 0.0 0.00016 20.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDI80390.1 - 0.0028 17.6 0.0 0.013 15.4 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDI80390.1 - 0.0077 15.6 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_10 PF14788.6 CDI80390.1 - 0.012 15.4 1.9 3.6 7.5 0.0 3.5 3 1 1 4 4 4 0 EF hand EF-hand_9 PF14658.6 CDI80390.1 - 0.051 13.9 0.4 0.5 10.7 0.1 2.6 2 1 0 2 2 2 0 EF-hand domain Elf1 PF05129.13 CDI80391.1 - 4.5e-27 93.9 0.1 1.1e-26 92.7 0.1 1.7 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 CDI80391.1 - 0.042 14.2 1.6 0.16 12.4 1.6 2.0 1 1 0 1 1 1 0 Restriction alleviation protein Lar Dehydrin PF00257.19 CDI80391.1 - 0.13 12.8 23.1 0.39 11.3 23.1 1.8 1 1 0 1 1 1 0 Dehydrin GREB1 PF15782.5 CDI80391.1 - 2.5 5.1 5.4 3 4.8 5.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NTP_transferase PF00483.23 CDI80392.1 - 1.1e-33 116.8 1.9 1.2e-17 64.4 0.1 2.7 1 1 0 2 2 2 2 Nucleotidyl transferase Hexapep PF00132.24 CDI80392.1 - 1.2e-06 28.0 0.8 2.9e-06 26.8 0.8 1.7 1 0 0 1 1 1 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDI80392.1 - 1.6e-05 24.6 2.0 3.8e-05 23.3 2.0 1.7 1 0 0 1 1 1 1 Hexapeptide repeat of succinyl-transferase DUF2722 PF10846.8 CDI80392.1 - 0.028 13.4 0.1 0.028 13.4 0.1 5.4 4 1 1 5 5 5 0 Protein of unknown function (DUF2722) Mlh1_C PF16413.5 CDI80392.1 - 5.6 6.3 18.1 4.1 6.7 2.6 3.6 3 0 0 3 3 3 0 DNA mismatch repair protein Mlh1 C-terminus TFIIA PF03153.13 CDI80394.1 - 4.9 7.1 24.7 6 6.8 24.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3682 PF12446.8 CDI80394.1 - 5.8 7.4 18.7 0.67 10.4 14.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Suf PF05843.14 CDI80394.1 - 9.4 6.1 12.7 12 5.7 12.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Prenyltransf PF01255.19 CDI80395.1 - 3.9e-34 118.1 0.0 1.3e-33 116.4 0.0 1.7 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase RskA PF10099.9 CDI80395.1 - 2e-09 38.0 3.9 0.00019 21.8 0.0 2.3 1 1 1 2 2 2 2 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI80395.1 - 0.018 15.1 5.4 0.018 15.1 5.4 3.3 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 PARM PF17061.5 CDI80395.1 - 0.029 14.5 1.8 0.041 14.0 1.8 1.1 1 0 0 1 1 1 0 PARM DUF2052 PF09747.9 CDI80395.1 - 0.12 12.5 6.6 1.4 9.0 0.7 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Spt20 PF12090.8 CDI80395.1 - 0.29 10.7 34.5 0.048 13.3 12.9 2.1 2 0 0 2 2 2 0 Spt20 family Pex14_N PF04695.13 CDI80395.1 - 0.76 10.4 19.4 0.1 13.2 8.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 CDI80395.1 - 0.85 10.6 11.7 0.72 10.8 2.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CDI80395.1 - 5.9 7.6 18.4 19 5.9 0.1 2.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein Suf PF05843.14 CDI80395.1 - 9.8 6.1 12.3 2.2 8.2 4.1 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) FapA PF03961.13 CDI80396.1 - 1.2 7.7 6.3 1.8 7.1 6.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A SUIM_assoc PF16619.5 CDI80397.1 - 0.012 15.6 7.0 0.029 14.4 7.0 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI80397.1 - 0.023 14.3 5.0 0.021 14.4 5.0 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI80397.1 - 0.094 12.7 9.5 0.11 12.5 9.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LapA_dom PF06305.11 CDI80398.1 - 0.001 18.8 0.8 0.001 18.8 0.8 2.2 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain WBP-1 PF11669.8 CDI80398.1 - 0.014 16.0 0.5 0.014 16.0 0.5 2.3 3 0 0 3 3 2 0 WW domain-binding protein 1 CcmH PF03918.14 CDI80398.1 - 0.024 13.9 0.3 0.024 13.9 0.3 2.8 3 0 0 3 3 3 0 Cytochrome C biogenesis protein DUF4834 PF16118.5 CDI80398.1 - 0.058 14.4 2.6 0.058 14.4 2.6 3.7 3 1 0 4 4 4 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDI80398.1 - 0.067 14.1 1.6 0.37 11.7 0.1 2.8 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain STE3 PF02076.15 CDI80398.1 - 0.22 10.7 0.2 0.35 10.1 0.2 1.2 1 0 0 1 1 1 0 Pheromone A receptor Neur_chan_memb PF02932.16 CDI80398.1 - 0.37 10.8 8.5 0.03 14.4 0.7 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PEX11 PF05648.14 CDI80398.1 - 0.46 9.9 4.3 0.58 9.6 1.0 2.4 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) BatA PF07584.11 CDI80398.1 - 4.8 7.6 9.0 2.9 8.3 4.0 2.6 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal SOBP PF15279.6 CDI80398.1 - 7.2 7.1 20.3 8.5 6.9 2.5 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein Connexin PF00029.19 CDI80398.1 - 9.4 5.9 6.9 27 4.4 6.9 1.8 1 1 0 1 1 1 0 Connexin Prenyltrans PF00432.21 CDI80400.1 - 2.9e-15 55.7 29.6 4.4e-09 35.9 1.0 5.1 6 0 0 6 6 5 3 Prenyltransferase and squalene oxidase repeat RskA PF10099.9 CDI80400.1 - 1.4e-05 25.5 9.0 2.6e-05 24.6 9.0 1.5 1 0 0 1 1 1 1 Anti-sigma-K factor rskA CCDC14 PF15254.6 CDI80400.1 - 0.00064 18.5 8.2 0.00084 18.1 8.2 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 Med15 PF09606.10 CDI80400.1 - 0.0018 17.1 8.4 0.0021 16.9 8.4 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI80400.1 - 0.0073 15.3 11.9 0.013 14.5 11.8 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Myc_N PF01056.18 CDI80400.1 - 0.011 15.7 0.5 0.014 15.3 0.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DivIC PF04977.15 CDI80400.1 - 0.035 13.9 8.7 0.063 13.1 8.7 1.4 1 0 0 1 1 1 0 Septum formation initiator TFIIA PF03153.13 CDI80400.1 - 0.053 13.5 17.0 0.072 13.1 17.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI80400.1 - 0.058 11.9 1.1 0.077 11.5 1.1 1.1 1 0 0 1 1 1 0 FHIPEP family Suf PF05843.14 CDI80400.1 - 0.085 12.8 3.7 0.1 12.5 3.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4820 PF16091.5 CDI80400.1 - 0.17 11.2 3.4 0.26 10.6 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DNApol_Exo PF18136.1 CDI80400.1 - 0.19 10.8 3.7 0.3 10.2 3.7 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Spt20 PF12090.8 CDI80400.1 - 0.2 11.3 22.7 0.3 10.7 22.7 1.2 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CDI80400.1 - 0.38 9.5 3.1 0.5 9.1 3.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 CDI80400.1 - 0.53 11.3 7.2 0.96 10.5 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 CDI80400.1 - 1.1 8.9 4.7 1.7 8.3 4.7 1.2 1 0 0 1 1 1 0 FAM176 family TERB2 PF15101.6 CDI80400.1 - 1.4 8.9 8.7 2.4 8.2 8.7 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF3464 PF11947.8 CDI80400.1 - 1.4 8.6 5.1 2.9 7.6 5.1 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 UPF0560 PF10577.9 CDI80400.1 - 3.3 6.1 11.2 4.4 5.7 11.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Activator_LAG-3 PF11498.8 CDI80400.1 - 4.8 6.0 25.1 7.6 5.4 25.1 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Pam16 PF03656.13 CDI80401.1 - 0.0076 16.3 1.7 0.0076 16.3 1.7 2.8 2 1 2 4 4 4 1 Pam16 TFIIA PF03153.13 CDI80401.1 - 0.17 11.9 5.7 0.24 11.3 5.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI80401.1 - 7.4 6.1 9.0 2.4 7.7 2.8 2.1 2 0 0 2 2 2 0 Spt20 family O-antigen_lig PF13425.6 CDI80403.1 - 0.97 8.1 5.8 1.7 7.4 5.8 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RAP1 PF07218.11 CDI80403.1 - 1.4 7.1 22.2 1.7 6.8 22.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SWI-SNF_Ssr4 PF08549.10 CDI80403.1 - 3.3 6.2 25.0 4.1 5.9 25.0 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF4746 PF15928.5 CDI80403.1 - 7.9 5.8 20.8 0.52 9.7 14.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) SRCR PF00530.18 CDI80404.1 - 3.3e-25 88.5 14.0 5.9e-19 68.4 4.1 3.2 2 1 0 2 2 2 2 Scavenger receptor cysteine-rich domain LCCL PF03815.19 CDI80404.1 - 1.3e-17 63.7 0.0 7.9e-17 61.2 0.0 2.3 2 0 0 2 2 2 1 LCCL domain PLAT PF01477.23 CDI80404.1 - 4.2e-09 37.0 0.0 3.1e-08 34.2 0.0 2.4 1 1 2 3 3 3 1 PLAT/LH2 domain SRCR_2 PF15494.6 CDI80404.1 - 2.4e-05 24.8 0.6 5.4e-05 23.7 0.6 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF3875 PF12991.7 CDI80404.1 - 0.0057 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function, B. Theta Gene description (DUF3875) MlaD PF02470.20 CDI80404.1 - 0.19 12.0 0.0 0.43 10.9 0.0 1.6 1 0 0 1 1 1 0 MlaD protein VWA_N2 PF16164.5 CDI80408.1 - 0.28 11.3 3.6 0.44 10.7 0.6 2.9 2 0 0 2 2 2 0 VWA N-terminal WD40 PF00400.32 CDI80409.1 - 2.8e-15 56.4 7.3 0.033 15.1 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 CDI80409.1 - 3.6e-07 30.5 0.2 9.3e-07 29.1 0.2 1.7 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 CDI80409.1 - 3.7e-06 27.1 0.0 1.4 9.3 0.0 4.2 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain FBA PF04300.13 CDI80409.1 - 1.3 8.7 4.3 7.1 6.3 1.2 2.5 2 0 0 2 2 2 0 F-box associated region Anillin PF08174.11 CDI80409.1 - 4.7 7.6 5.7 0.71 10.3 1.0 2.0 2 0 0 2 2 2 0 Cell division protein anillin DnaJ PF00226.31 CDI80411.1 - 0.2 11.8 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 DnaJ domain SPX PF03105.19 CDI80412.1 - 0.015 15.2 0.5 0.015 15.2 0.5 3.2 2 1 1 3 3 3 0 SPX domain DUF4746 PF15928.5 CDI80412.1 - 0.057 12.8 22.4 0.026 13.9 15.3 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Adaptin_binding PF10199.9 CDI80412.1 - 0.46 11.1 0.0 0.46 11.1 0.0 4.8 2 2 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 MutS_V PF00488.21 CDI80413.1 - 5.3e-45 153.8 0.1 6.2e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 MutS domain V AAA_29 PF13555.6 CDI80413.1 - 0.013 15.2 0.4 0.028 14.2 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CDI80413.1 - 0.082 13.4 0.0 0.082 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDI80413.1 - 0.12 12.4 0.1 0.33 11.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 CDI80413.1 - 0.17 11.0 0.2 0.28 10.3 0.2 1.3 1 0 0 1 1 1 0 G-protein alpha subunit MutS_III PF05192.18 CDI80414.1 - 2.8e-27 96.2 1.6 2.8e-27 96.2 1.6 3.5 2 2 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 CDI80414.1 - 1.9e-07 31.3 0.2 4e-07 30.3 0.2 1.6 1 0 0 1 1 1 1 MutS family domain IV DUF1645 PF07816.11 CDI80414.1 - 0.016 15.8 6.5 0.016 15.8 6.5 4.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1645) RskA PF10099.9 CDI80414.1 - 0.088 13.1 77.8 0.14 12.4 8.5 5.1 2 1 2 4 4 4 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI80415.1 - 1.3e-07 32.0 53.0 0.00012 22.3 21.9 3.2 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI80415.1 - 0.00037 20.4 10.2 0.00037 20.4 10.2 3.1 3 0 0 3 3 3 1 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI80415.1 - 0.28 9.6 3.0 0.5 8.7 3.0 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DDHD PF02862.17 CDI80415.1 - 0.62 10.2 19.3 0.12 12.6 5.7 3.4 3 0 0 3 3 3 0 DDHD domain BAF1_ABF1 PF04684.13 CDI80415.1 - 2 7.4 19.2 0.025 13.6 6.6 2.9 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor Membralin PF09746.9 CDI80415.1 - 2.6 7.0 5.7 6.3 5.7 5.7 1.6 1 0 0 1 1 1 0 Tumour-associated protein TRAP_alpha PF03896.16 CDI80415.1 - 3.2 6.9 10.0 8.6 5.5 10.0 1.7 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TruD PF01142.18 CDI80416.1 - 3e-48 164.7 3.2 1.7e-46 158.9 0.7 4.0 4 1 0 4 4 4 2 tRNA pseudouridine synthase D (TruD) HEM4 PF02602.15 CDI80417.1 - 4.3e-07 29.5 31.1 0.00015 21.2 14.0 4.4 3 2 1 4 4 4 2 Uroporphyrinogen-III synthase HemD CitMHS_2 PF16980.5 CDI80417.1 - 0.096 11.3 0.4 0.2 10.3 0.4 1.5 1 0 0 1 1 1 0 Putative citrate transport Spore_YhcN_YlaJ PF09580.10 CDI80417.1 - 0.26 11.3 0.0 0.26 11.3 0.0 4.6 4 1 0 4 4 4 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) LAGLIDADG_WhiA PF14527.6 CDI80417.1 - 1.2 9.2 3.6 2.6 8.2 3.6 1.6 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain MtN3_slv PF03083.16 CDI80418.1 - 9.1e-14 51.3 5.4 8.5e-08 32.1 0.2 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange EPL1 PF10513.9 CDI80418.1 - 0.023 15.1 6.9 1.8 8.9 3.7 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like Tfb4 PF03850.14 CDI80424.1 - 2.9e-14 53.2 1.6 1.8e-13 50.6 0.0 2.5 2 1 1 3 3 3 1 Transcription factor Tfb4 DUF2722 PF10846.8 CDI80424.1 - 0.0002 20.4 1.3 0.0002 20.4 1.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI80424.1 - 0.058 13.0 12.4 0.11 12.1 12.4 1.4 1 0 0 1 1 1 0 Spt20 family DHHC PF01529.20 CDI80425.1 - 2.3e-24 86.0 7.9 4.6e-21 75.3 5.5 2.3 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF936 PF06075.12 CDI80425.1 - 6.6 5.5 51.8 0.9 8.4 42.4 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF936) MDFI PF15316.6 CDI80426.1 - 0.079 13.0 0.9 0.1 12.7 0.9 1.2 1 0 0 1 1 1 0 MyoD family inhibitor SR-25 PF10500.9 CDI80426.1 - 0.28 10.8 19.2 0.37 10.4 19.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3138 PF11336.8 CDI80426.1 - 0.32 9.5 12.0 0.42 9.2 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) GREB1 PF15782.5 CDI80426.1 - 0.34 8.0 4.4 0.39 7.8 4.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 CDI80426.1 - 1.6 8.3 12.0 2.1 7.9 12.0 1.1 1 0 0 1 1 1 0 Spt20 family Helicase_C_2 PF13307.6 CDI80428.1 - 5.6e-38 130.8 4.2 5.6e-38 130.8 4.2 3.9 2 1 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDI80428.1 - 3.2e-17 62.7 0.0 3.2e-17 62.7 0.0 2.8 2 0 0 2 2 2 1 DEAD_2 Helicase_C PF00271.31 CDI80429.1 - 0.0012 19.1 0.0 0.064 13.6 0.0 3.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF2722 PF10846.8 CDI80429.1 - 0.0051 15.8 18.3 0.0051 15.8 18.3 6.6 4 2 2 6 6 6 2 Protein of unknown function (DUF2722) U1snRNP70_N PF12220.8 CDI80429.1 - 3.4 8.4 46.0 4.1 8.1 3.1 4.9 4 0 0 4 4 4 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MORN PF02493.20 CDI80430.1 - 1.7e-92 298.1 100.7 1.3e-09 37.4 2.3 14.4 14 0 0 14 14 14 14 MORN repeat TAA-Trp-ring PF15401.6 CDI80430.1 - 0.12 12.8 5.4 0.17 12.3 1.3 2.9 1 1 1 2 2 2 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin NCBP3 PF10309.9 CDI80430.1 - 1.1 9.1 4.8 23 5.0 0.1 3.8 3 1 1 4 4 4 0 Nuclear cap-binding protein subunit 3 Serpin PF00079.20 CDI80433.1 - 2.6e-78 263.9 0.2 3e-78 263.7 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PrmA PF06325.13 CDI80434.1 - 0.05 13.0 0.0 0.31 10.4 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_3 PF01596.17 CDI80434.1 - 0.084 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase PRMT5_C PF17286.2 CDI80434.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 1 0 1 1 1 0 PRMT5 oligomerisation domain CMAS PF02353.20 CDI80434.1 - 0.21 10.8 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Peptidase_S8 PF00082.22 CDI80435.1 - 1.3e-28 100.2 0.0 2.4e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 Subtilase family AP2 PF00847.20 CDI80436.1 - 4.7e-05 23.5 1.1 0.00074 19.7 1.5 2.6 2 0 0 2 2 2 1 AP2 domain MS_channel PF00924.18 CDI80437.1 - 1.4e-11 44.4 1.6 2.3e-11 43.6 1.6 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel tRNA_anti-codon PF01336.25 CDI80438.1 - 0.056 13.4 0.0 0.28 11.2 0.0 2.1 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain Trans_reg_C PF00486.28 CDI80438.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal FlgT_N PF16548.5 CDI80438.1 - 3.3 8.4 7.5 0.31 11.6 1.5 2.3 3 0 0 3 3 3 0 Flagellar assembly protein T, N-terminal domain SR-25 PF10500.9 CDI80438.1 - 8.5 5.9 11.8 0.48 10.0 5.8 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein UDPGP PF01704.18 CDI80439.1 - 3.6e-08 32.5 0.6 7e-08 31.5 0.5 1.5 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF5364 PF17322.2 CDI80439.1 - 0.0078 16.5 5.1 0.0078 16.5 5.1 2.3 2 1 0 2 2 2 1 Family of unknown function (DUF5364) SR-25 PF10500.9 CDI80439.1 - 0.014 15.0 10.4 0.045 13.4 5.3 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein NTP_transf_3 PF12804.7 CDI80439.1 - 0.023 15.1 4.2 0.11 12.9 0.0 3.1 3 0 0 3 3 3 0 MobA-like NTP transferase domain Topoisom_I_N PF02919.15 CDI80439.1 - 0.056 12.9 0.2 0.13 11.7 0.2 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF1512 PF07431.12 CDI80439.1 - 0.22 10.5 1.2 0.27 10.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) FTR PF01913.18 CDI80439.1 - 0.31 11.0 1.7 0.65 9.9 1.7 1.5 1 0 0 1 1 1 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase RskA PF10099.9 CDI80439.1 - 1 9.6 29.5 4.9 7.4 0.1 3.6 3 1 0 3 3 3 0 Anti-sigma-K factor rskA CCDC53 PF10152.9 CDI80439.1 - 1.3 9.4 17.4 2.1 8.8 8.8 2.8 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF4484 PF14831.6 CDI80439.1 - 7 6.6 11.5 0.26 11.3 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) RRM_1 PF00076.22 CDI80440.1 - 1.4e-05 24.8 0.0 2.9e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 CDI80440.1 - 0.0048 16.8 0.0 0.01 15.7 0.0 1.6 1 1 0 1 1 1 1 RL domain DUF883 PF05957.13 CDI80440.1 - 0.26 11.9 9.3 0.41 11.3 9.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF1744 PF08490.12 CDI80442.1 - 2.8e-19 69.0 0.1 2.8e-19 69.0 0.1 4.4 2 2 0 2 2 2 1 Domain of unknown function (DUF1744) RskA PF10099.9 CDI80442.1 - 0.0023 18.2 53.7 0.02 15.2 0.0 7.9 6 2 2 8 8 8 4 Anti-sigma-K factor rskA CNDH2_C PF16858.5 CDI80442.1 - 2 8.2 25.7 0.89 9.4 0.4 2.7 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Velvet PF11754.8 CDI80443.1 - 4.1 7.3 7.1 12 5.7 7.1 1.9 1 1 0 1 1 1 0 Velvet factor RRM_1 PF00076.22 CDI80444.1 - 1.8e-06 27.6 0.0 0.003 17.3 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAP_C PF08603.11 CDI80445.1 - 9.9e-52 174.7 1.1 1.1e-51 174.6 1.1 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 CDI80445.1 - 1.6e-05 24.6 0.4 2.3e-05 24.1 0.4 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C DUF918 PF06033.11 CDI80445.1 - 0.049 13.6 0.3 0.26 11.3 0.1 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF918) WBP-1 PF11669.8 CDI80447.1 - 0.15 12.7 0.5 0.27 11.9 0.5 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 Glucan_synthase PF02364.15 CDI80449.1 - 7.6e-86 289.0 9.0 3.7e-30 104.8 0.0 4.3 3 1 0 4 4 4 4 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 CDI80449.1 - 1.6e-12 47.9 5.7 2.2e-10 41.0 5.7 2.5 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 LID PF17916.1 CDI80450.1 - 0.041 13.5 0.2 0.1 12.2 0.2 1.6 1 0 0 1 1 1 0 LIM interaction domain (LID) MORN PF02493.20 CDI80453.1 - 8.7e-35 116.6 42.6 4.5e-06 26.2 4.3 8.3 9 0 0 9 9 9 7 MORN repeat Tudor_2 PF18104.1 CDI80453.1 - 0.36 10.5 3.7 8.7 6.1 0.0 3.9 3 1 1 4 4 4 0 Jumonji domain-containing protein 2A Tudor domain Ribosomal_L7Ae PF01248.26 CDI80454.1 - 6.7e-13 48.2 0.1 9.7e-13 47.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 CDI80454.1 - 0.0017 18.4 0.0 0.0022 18.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase INTS5_N PF14837.6 CDI80454.1 - 0.014 15.0 0.1 0.021 14.4 0.1 1.3 1 1 0 1 1 1 0 Integrator complex subunit 5 N-terminus Spt20 PF12090.8 CDI80454.1 - 0.16 11.5 9.6 0.18 11.4 9.6 1.2 1 0 0 1 1 1 0 Spt20 family APP_Cu_bd PF12924.7 CDI80454.1 - 0.2 12.4 1.6 0.58 10.9 0.0 2.2 2 1 0 2 2 2 0 Copper-binding of amyloid precursor, CuBD Androgen_recep PF02166.16 CDI80454.1 - 4.5 6.0 11.2 5.3 5.8 11.2 1.1 1 0 0 1 1 1 0 Androgen receptor RskA PF10099.9 CDI80455.1 - 0.0027 18.0 34.8 0.0047 17.2 5.9 7.1 3 2 4 7 7 7 3 Anti-sigma-K factor rskA Ribosomal_S4 PF00163.19 CDI80456.1 - 5.3e-08 33.7 0.5 8.1e-08 33.1 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 CDI80456.1 - 0.00081 19.1 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 S4 domain SUIM_assoc PF16619.5 CDI80457.1 - 0.00036 20.6 1.9 0.00036 20.6 1.9 4.8 4 0 0 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 Surface_antigen PF11054.8 CDI80458.1 - 5.7e-19 68.7 23.2 2e-08 34.2 0.5 6.2 1 1 2 3 3 3 3 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI80459.1 - 4.4e-23 82.2 16.3 8.7e-11 42.0 4.6 3.9 1 1 2 3 3 3 3 Sporozoite TA4 surface antigen T2SSF PF00482.23 CDI80460.1 - 0.039 13.9 0.7 0.45 10.5 0.2 2.9 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F Surface_antigen PF11054.8 CDI80461.1 - 0.001 18.8 0.3 0.0037 17.0 0.1 1.9 2 0 0 2 2 2 1 Sporozoite TA4 surface antigen Surface_antigen PF11054.8 CDI80462.1 - 1.7e-10 41.0 5.0 1.5e-09 37.9 1.3 2.3 1 1 1 2 2 2 2 Sporozoite TA4 surface antigen SPT2 PF08243.11 CDI80463.1 - 4.6e-09 36.8 9.9 4.6e-09 36.8 9.9 6.4 7 2 1 8 8 8 1 SPT2 chromatin protein SR-25 PF10500.9 CDI80463.1 - 0.0088 15.7 11.3 0.0088 15.7 11.3 7.1 3 2 4 7 7 7 1 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI80463.1 - 0.063 13.4 0.0 0.063 13.4 0.0 12.9 6 3 3 10 10 10 0 Unstructured region C-term to UIM in Ataxin3 MCM PF00493.23 CDI80464.1 - 3.3e-63 212.8 0.3 7.2e-53 179.0 0.0 3.2 2 1 1 3 3 3 3 MCM P-loop domain MCM_lid PF17855.1 CDI80464.1 - 1.7e-20 73.2 0.4 4.8e-20 71.8 0.1 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_OB PF17207.3 CDI80464.1 - 2.5e-19 69.3 0.2 7.6e-19 67.8 0.2 1.8 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 CDI80464.1 - 2.7e-07 30.2 0.3 1.6e-06 27.7 0.0 2.3 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 CDI80464.1 - 5.9e-07 30.0 0.8 2.1e-06 28.2 0.8 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Sigma54_activat PF00158.26 CDI80464.1 - 0.006 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Kelch_1 PF01344.25 CDI80466.1 - 2.1e-19 68.8 1.4 4.3e-12 45.4 0.2 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 CDI80466.1 - 2.4e-09 37.1 4.3 1.6e-06 28.1 0.0 4.0 3 1 1 4 4 4 1 Kelch motif Kelch_2 PF07646.15 CDI80466.1 - 5e-06 26.3 0.1 4e-05 23.4 0.0 2.6 2 0 0 2 2 2 1 Kelch motif DUF2722 PF10846.8 CDI80466.1 - 6.8e-05 22.0 8.1 0.00014 21.0 8.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI80466.1 - 0.00032 20.4 14.2 0.00032 20.4 14.2 1.9 3 0 0 3 3 1 1 Spt20 family Kelch_5 PF13854.6 CDI80466.1 - 0.0053 16.7 0.0 1.7 8.8 0.0 3.0 3 0 0 3 3 2 1 Kelch motif EPL1 PF10513.9 CDI80466.1 - 0.012 15.9 1.1 0.032 14.6 1.1 1.7 1 0 0 1 1 1 0 Enhancer of polycomb-like Lin-8 PF03353.15 CDI80466.1 - 0.019 14.5 5.5 0.044 13.3 5.5 1.6 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4770 PF15994.5 CDI80466.1 - 0.036 14.3 4.3 0.081 13.2 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Kelch_3 PF13415.6 CDI80466.1 - 0.067 13.5 1.5 0.54 10.6 0.1 3.1 3 0 0 3 3 2 0 Galactose oxidase, central domain DUF4834 PF16118.5 CDI80466.1 - 0.94 10.5 7.0 3.5 8.6 7.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peptidase_S64 PF08192.11 CDI80466.1 - 2.2 6.7 5.5 3.8 5.9 5.5 1.3 1 0 0 1 1 1 0 Peptidase family S64 SpoIIP PF07454.11 CDI80466.1 - 2.7 7.4 6.6 4.9 6.5 6.6 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3464 PF11947.8 CDI80466.1 - 3 7.6 8.5 15 5.4 8.5 2.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Hid1 PF12722.7 CDI80466.1 - 3.1 5.8 4.9 4.9 5.2 4.9 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CPSF100_C PF13299.6 CDI80466.1 - 9 6.4 14.0 1 9.5 1.0 3.8 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal LIM_bind PF01803.16 CDI80466.1 - 9.5 5.7 9.1 7.3 6.0 3.8 2.4 2 0 0 2 2 2 0 LIM-domain binding protein Pkinase PF00069.25 CDI80467.1 - 3.2e-22 79.2 1.1 3.2e-22 79.2 1.1 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80467.1 - 1.5e-10 40.9 2.6 1.6e-10 40.7 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 CDI80467.1 - 0.22 10.5 0.0 0.35 9.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 MMR1 PF08505.10 CDI80467.1 - 0.99 9.6 25.0 0.73 10.1 5.6 2.6 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein EIF4E-T PF10477.9 CDI80468.1 - 0.00032 19.7 11.5 0.00032 19.7 11.5 2.7 3 0 0 3 3 3 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TFIIA PF03153.13 CDI80468.1 - 0.023 14.7 27.0 0.54 10.2 17.2 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Imm48 PF15574.6 CDI80468.1 - 0.094 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 48 SPX PF03105.19 CDI80468.1 - 1.8 8.4 27.2 0.097 12.6 13.2 2.6 2 1 0 2 2 2 0 SPX domain MSP1_C PF07462.11 CDI80469.1 - 0.086 11.5 5.2 0.11 11.1 5.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Spt20 PF12090.8 CDI80469.1 - 0.48 10.0 37.8 0.19 11.3 9.6 3.2 3 0 0 3 3 3 0 Spt20 family 5-FTHF_cyc-lig PF01812.20 CDI80471.1 - 4.2e-15 56.1 9.9 1e-11 45.0 8.7 2.5 2 1 0 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family Presenilin PF01080.17 CDI80471.1 - 3e-05 23.0 3.0 3e-05 23.0 3.0 1.7 2 0 0 2 2 2 1 Presenilin Pex14_N PF04695.13 CDI80471.1 - 0.00082 20.1 17.7 0.00082 20.1 17.7 3.0 3 1 0 3 3 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM60A PF15396.6 CDI80471.1 - 0.0023 18.0 3.7 0.0036 17.3 3.2 1.5 2 0 0 2 2 1 1 Protein Family FAM60A DUF4337 PF14235.6 CDI80471.1 - 0.0035 17.5 13.1 0.0035 17.5 13.1 2.3 3 0 0 3 3 2 1 Domain of unknown function (DUF4337) CobT PF06213.12 CDI80471.1 - 0.0046 16.4 14.9 0.0046 16.4 14.9 2.0 2 0 0 2 2 2 1 Cobalamin biosynthesis protein CobT RskA PF10099.9 CDI80471.1 - 0.0066 16.8 0.2 0.0066 16.8 0.2 4.6 1 1 2 3 3 1 1 Anti-sigma-K factor rskA DUF4366 PF14283.6 CDI80471.1 - 0.0091 16.0 5.8 0.0091 16.0 5.8 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4366) Connexin PF00029.19 CDI80471.1 - 0.011 15.5 5.0 0.02 14.7 5.0 1.4 1 0 0 1 1 1 0 Connexin TYW3 PF02676.14 CDI80471.1 - 0.016 14.6 1.9 0.032 13.6 1.9 1.5 1 0 0 1 1 1 0 Methyltransferase TYW3 UPF0565 PF10561.9 CDI80471.1 - 0.036 13.3 3.4 0.065 12.4 3.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Hid1 PF12722.7 CDI80471.1 - 0.038 12.1 7.5 0.055 11.6 7.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FPN1 PF06963.12 CDI80471.1 - 0.038 12.5 3.3 0.064 11.8 3.3 1.3 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF4658 PF15555.6 CDI80471.1 - 0.053 13.6 0.8 0.053 13.6 0.8 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4658) CK_II_beta PF01214.18 CDI80471.1 - 0.055 13.3 6.2 0.11 12.3 6.2 1.5 1 0 0 1 1 1 0 Casein kinase II regulatory subunit LptF_LptG PF03739.14 CDI80471.1 - 0.062 12.1 2.1 0.093 11.6 2.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG GREB1 PF15782.5 CDI80471.1 - 0.073 10.2 10.1 0.097 9.8 10.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer OATP PF03137.20 CDI80471.1 - 0.13 10.5 4.8 0.22 9.8 4.8 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CSG2 PF16965.5 CDI80471.1 - 0.13 11.2 7.0 0.23 10.3 7.0 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2370 PF10176.9 CDI80471.1 - 0.14 11.8 3.8 0.28 10.8 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SLC12 PF03522.15 CDI80471.1 - 0.15 11.1 12.5 0.28 10.1 12.5 1.4 1 0 0 1 1 1 0 Solute carrier family 12 LMBR1 PF04791.16 CDI80471.1 - 0.2 10.5 5.3 0.29 10.0 5.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF913 PF06025.12 CDI80471.1 - 0.21 10.5 10.1 0.045 12.7 7.0 1.4 2 0 0 2 2 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 CDI80471.1 - 0.21 11.7 11.5 0.21 11.8 8.0 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pex16 PF08610.10 CDI80471.1 - 0.23 10.6 7.3 0.13 11.4 4.7 1.8 2 0 0 2 2 2 0 Peroxisomal membrane protein (Pex16) SUIM_assoc PF16619.5 CDI80471.1 - 0.28 11.3 0.1 0.28 11.3 0.1 6.2 3 1 1 4 4 2 0 Unstructured region C-term to UIM in Ataxin3 HCO3_cotransp PF00955.21 CDI80471.1 - 0.32 9.8 8.8 0.47 9.2 8.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF4746 PF15928.5 CDI80471.1 - 0.35 10.3 8.8 0.19 11.1 6.8 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4746) Dynamin_N PF00350.23 CDI80471.1 - 0.54 10.3 6.8 0.081 13.0 1.9 1.9 2 0 0 2 2 2 0 Dynamin family Scs3p PF10261.9 CDI80471.1 - 0.61 9.6 5.5 1.2 8.5 5.5 1.4 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF3675 PF12428.8 CDI80471.1 - 0.65 10.6 5.0 2.3 8.8 5.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3675) Cellulose_synt PF03552.14 CDI80471.1 - 0.95 7.9 4.3 1.2 7.5 4.3 1.1 1 0 0 1 1 1 0 Cellulose synthase SpoIIP PF07454.11 CDI80471.1 - 1.1 8.7 14.6 0.16 11.4 10.8 1.5 2 0 0 2 2 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 CDI80471.1 - 1.2 8.1 11.5 2 7.3 11.5 1.3 1 0 0 1 1 1 0 CLN3 protein Ndc1_Nup PF09531.10 CDI80471.1 - 1.4 7.5 12.4 0.1 11.3 5.5 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup V_ATPase_I PF01496.19 CDI80471.1 - 1.9 6.3 16.7 2.9 5.7 16.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PRP1_N PF06424.12 CDI80471.1 - 1.9 8.8 16.6 1.2 9.5 14.1 1.8 2 0 0 2 2 1 0 PRP1 splicing factor, N-terminal ALMT PF11744.8 CDI80471.1 - 2 7.2 14.1 2.8 6.7 14.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PPL5 PF18168.1 CDI80471.1 - 2.3 7.4 10.0 4.2 6.6 10.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Sec62 PF03839.16 CDI80471.1 - 2.5 7.5 13.1 4.7 6.7 13.1 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Peptidase_U57 PF05582.12 CDI80471.1 - 2.8 7.1 12.8 5.5 6.2 12.8 1.4 1 0 0 1 1 1 0 YabG peptidase U57 O-antigen_lig PF13425.6 CDI80471.1 - 2.9 6.6 6.4 4.4 6.0 6.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2126 PF09899.9 CDI80471.1 - 3.4 5.6 11.2 5 5.1 11.2 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) CBP_BcsG PF11658.8 CDI80471.1 - 3.6 5.9 14.9 3.7 5.8 13.7 1.6 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG RR_TM4-6 PF06459.12 CDI80471.1 - 3.7 7.3 16.9 1.3 8.8 14.1 1.6 2 0 0 2 2 1 0 Ryanodine Receptor TM 4-6 DUF3040 PF11239.8 CDI80471.1 - 3.7 7.9 6.6 7.7 6.9 2.2 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3040) Consortin_C PF15281.6 CDI80471.1 - 4.6 7.3 11.1 52 3.9 11.1 2.3 1 1 0 1 1 1 0 Consortin C-terminus AUX_IAA PF02309.16 CDI80471.1 - 5 6.9 9.9 3.3 7.5 7.7 1.7 2 0 0 2 2 2 0 AUX/IAA family Ctr PF04145.15 CDI80471.1 - 5.1 7.7 13.7 14 6.3 12.3 2.1 2 0 0 2 2 2 0 Ctr copper transporter family Paramyxo_ncap PF00973.19 CDI80471.1 - 5.4 5.8 9.4 7.8 5.3 9.4 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF3292 PF11696.8 CDI80471.1 - 5.6 5.2 12.2 0.25 9.7 6.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) DUF2828 PF11443.8 CDI80471.1 - 6.4 4.7 15.9 2.1 6.3 13.3 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) SID-1_RNA_chan PF13965.6 CDI80471.1 - 7.2 4.9 6.9 10 4.4 6.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BORG_CEP PF14957.6 CDI80471.1 - 7.8 7.7 11.1 1.2 10.3 6.3 2.0 2 1 0 2 2 2 0 Cdc42 effector Vac7 PF12751.7 CDI80471.1 - 8.4 5.7 10.7 19 4.6 10.7 1.5 1 1 0 1 1 1 0 Vacuolar segregation subunit 7 YABBY PF04690.13 CDI80471.1 - 9 6.8 18.0 0.66 10.5 12.0 2.2 3 0 0 3 3 1 0 YABBY protein PIP5K PF01504.18 CDI80471.1 - 9.5 5.4 14.0 7.7 5.6 12.5 1.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Pkinase PF00069.25 CDI80472.1 - 8.7e-27 94.1 0.0 4.4e-19 68.9 0.0 4.1 3 1 1 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80472.1 - 1.3e-11 44.3 0.0 3e-10 39.8 0.0 2.9 3 1 1 4 4 4 1 Protein tyrosine kinase SUIM_assoc PF16619.5 CDI80472.1 - 0.017 15.2 0.0 0.017 15.2 0.0 6.4 4 3 2 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 T2SSF PF00482.23 CDI80472.1 - 0.018 15.0 0.5 0.018 15.0 0.5 3.3 5 0 0 5 5 5 0 Type II secretion system (T2SS), protein F APH PF01636.23 CDI80472.1 - 0.019 14.9 0.7 0.019 14.9 0.7 3.4 3 2 0 3 3 3 0 Phosphotransferase enzyme family SR-25 PF10500.9 CDI80473.1 - 0.00021 21.0 8.8 0.00021 21.0 8.8 9.9 8 1 3 11 11 11 4 Nuclear RNA-splicing-associated protein PAP_assoc PF03828.19 CDI80473.1 - 0.0012 19.0 0.1 0.0064 16.7 0.1 2.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase Caldesmon PF02029.15 CDI80473.1 - 0.0046 15.8 0.8 0.0046 15.8 0.8 5.1 5 1 1 6 6 6 1 Caldesmon Polbeta PF18765.1 CDI80473.1 - 0.0053 16.8 0.0 0.014 15.5 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 CDI80473.1 - 0.011 16.0 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain TFIIA PF03153.13 CDI80474.1 - 4.6 7.1 37.8 6.7 6.6 37.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 CDI80477.1 - 6.5e-36 124.0 0.0 7e-15 55.1 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80477.1 - 1.1e-09 37.9 0.0 0.00024 20.5 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase SARAF PF06682.12 CDI80477.1 - 0.00036 20.3 2.1 0.00036 20.3 2.1 5.1 4 1 0 4 4 4 2 SOCE-associated regulatory factor of calcium homoeostasis Sas6_CC PF18594.1 CDI80477.1 - 0.22 11.3 0.5 1.1 9.0 0.5 2.3 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain Lig_chan PF00060.26 CDI80477.1 - 0.31 10.9 4.4 0.15 11.9 1.7 1.9 2 0 0 2 2 2 0 Ligand-gated ion channel AMP-binding PF00501.28 CDI80478.1 - 0.034 12.7 6.5 0.67 8.5 4.7 3.0 2 2 0 2 2 2 0 AMP-binding enzyme PIP5K PF01504.18 CDI80479.1 - 0.24 10.6 5.5 0.35 10.1 5.5 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Med8 PF10232.9 CDI80479.1 - 3.1 7.3 14.8 72 2.8 14.8 2.1 1 1 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Tub_N PF16322.5 CDI80479.1 - 6.2 7.2 18.4 12 6.3 18.4 1.5 1 1 0 1 1 1 0 Tubby N-terminal SUIM_assoc PF16619.5 CDI80483.1 - 0.00024 21.1 1.3 0.00024 21.1 1.3 11.0 9 2 0 9 9 9 2 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI80483.1 - 0.0038 16.3 13.4 0.0038 16.3 13.4 7.5 5 1 2 7 7 7 4 Protein of unknown function (DUF2722) Abhydrolase_1 PF00561.20 CDI80484.1 - 3e-25 89.4 0.9 3e-25 89.4 0.9 2.9 3 1 0 3 3 3 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDI80484.1 - 1.6e-21 76.7 6.7 1.7e-18 66.8 0.1 2.8 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDI80484.1 - 4.2e-15 57.0 0.3 1.9e-14 54.8 0.3 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CDI80484.1 - 8.2e-08 32.1 0.2 4e-06 26.6 0.0 3.3 1 1 1 3 3 3 1 Dienelactone hydrolase family Ndr PF03096.14 CDI80484.1 - 3.4e-05 22.7 0.4 0.00055 18.7 0.0 2.4 2 0 0 2 2 2 1 Ndr family BAAT_C PF08840.11 CDI80484.1 - 4.1e-05 23.6 1.1 0.0064 16.4 0.0 3.3 3 1 1 4 4 3 2 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2048 PF09752.9 CDI80484.1 - 8.4e-05 21.8 0.0 0.00055 19.1 0.0 2.5 1 1 0 1 1 1 1 Abhydrolase domain containing 18 TFIIA PF03153.13 CDI80484.1 - 0.00013 22.1 86.6 0.027 14.5 21.8 4.1 4 0 0 4 4 4 3 Transcription factor IIA, alpha/beta subunit BAF1_ABF1 PF04684.13 CDI80484.1 - 0.00038 19.7 3.6 0.00038 19.7 3.6 3.9 4 0 0 4 4 4 2 BAF1 / ABF1 chromatin reorganising factor DUF1057 PF06342.12 CDI80484.1 - 0.0015 17.6 0.0 0.0027 16.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Esterase PF00756.20 CDI80484.1 - 0.002 17.8 7.8 0.002 17.8 7.8 3.3 3 1 0 3 3 2 1 Putative esterase DUF2722 PF10846.8 CDI80484.1 - 0.0026 16.8 7.8 0.0026 16.8 7.8 6.0 3 3 2 6 6 2 1 Protein of unknown function (DUF2722) Abhydrolase_5 PF12695.7 CDI80484.1 - 0.0043 16.8 0.0 0.015 15.1 0.0 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 CDI80484.1 - 0.02 13.8 0.0 0.048 12.6 0.0 1.6 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S9 PF00326.21 CDI80484.1 - 0.022 14.2 2.4 0.12 11.9 0.0 2.7 3 0 0 3 3 3 0 Prolyl oligopeptidase family PGAP1 PF07819.13 CDI80484.1 - 0.026 14.3 0.0 0.11 12.2 0.0 2.1 1 1 0 1 1 1 0 PGAP1-like protein Chlorophyllase PF07224.11 CDI80484.1 - 0.15 11.1 0.1 0.32 10.0 0.1 1.4 1 1 0 1 1 1 0 Chlorophyllase UPF0565 PF10561.9 CDI80484.1 - 0.16 11.2 0.0 0.16 11.2 0.0 4.3 4 1 0 4 4 3 0 Uncharacterised protein family UPF0565 Abhydrolase_3 PF07859.13 CDI80484.1 - 0.58 10.0 7.0 0.062 13.2 0.3 2.7 3 0 0 3 3 3 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDI80485.1 - 3.6e-13 49.3 0.2 5.2e-05 22.6 0.0 4.4 4 0 0 4 4 4 4 Serine aminopeptidase, S33 SDA1 PF05285.12 CDI80485.1 - 0.0091 15.5 4.4 0.0091 15.5 4.4 2.7 2 1 0 2 2 2 1 SDA1 ETRAMP PF09716.10 CDI80485.1 - 0.039 14.0 0.1 0.77 9.9 0.0 2.9 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) UPF0227 PF05728.12 CDI80485.1 - 0.04 13.9 0.0 0.04 13.9 0.0 3.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0227) eIF_4EBP PF05456.11 CDI80485.1 - 4.6 7.2 15.3 3.1 7.8 2.3 3.3 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) HSP70 PF00012.20 CDI80486.1 - 0.00011 20.5 0.1 0.00052 18.3 0.1 1.9 1 1 0 1 1 1 1 Hsp70 protein SUIM_assoc PF16619.5 CDI80486.1 - 0.066 13.3 8.0 1.1 9.4 2.7 3.1 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 MFS_1 PF07690.16 CDI80487.1 - 1.1e-07 31.2 27.4 1.1e-07 31.2 27.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily ERGIC_N PF13850.6 CDI80487.1 - 0.043 14.2 3.0 0.048 14.0 0.2 2.5 3 0 0 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PCNA_N PF00705.18 CDI80488.1 - 2.3e-23 82.3 0.7 1.2e-22 79.9 0.3 1.9 1 1 1 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 CDI80488.1 - 8.8e-08 32.4 0.0 5.2e-07 29.9 0.0 2.2 1 1 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 CDI80488.1 - 0.081 12.4 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Rad9 Lin-8 PF03353.15 CDI80491.1 - 0.0072 15.9 24.9 0.0072 15.9 24.9 3.5 3 1 0 3 3 3 1 Ras-mediated vulval-induction antagonist V_ATPase_I PF01496.19 CDI80491.1 - 2.6 5.8 20.0 0.037 12.0 12.1 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Aminotran_1_2 PF00155.21 CDI80492.1 - 8e-72 242.4 0.0 8e-72 242.4 0.0 3.6 2 1 2 4 4 4 1 Aminotransferase class I and II RAP1 PF07218.11 CDI80492.1 - 0.015 13.6 3.5 0.025 12.9 3.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SF3A3 PF16837.5 CDI80493.1 - 1.9e-13 50.7 0.8 5.7e-13 49.2 0.8 1.9 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 DUF3449 PF11931.8 CDI80493.1 - 1.2e-08 35.0 0.9 1.2e-08 35.0 0.9 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3a60_bindingd PF12108.8 CDI80493.1 - 3.6e-07 30.0 0.0 1.4e-06 28.0 0.0 2.1 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain ORC_WH_C PF18137.1 CDI80493.1 - 0.005 16.9 0.3 0.005 16.9 0.3 2.8 2 2 0 2 2 2 1 Origin recognition complex winged helix C-terminal Orthopox_F8 PF05886.11 CDI80493.1 - 0.035 14.2 0.6 0.11 12.7 0.6 1.8 1 0 0 1 1 1 0 Orthopoxvirus F8 protein Bac_GH3_C PF18034.1 CDI80493.1 - 0.054 13.3 0.1 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial Glycosyl hydrolase family 3 C-terminal domain SPATA6 PF14909.6 CDI80493.1 - 0.15 12.2 0.2 0.47 10.6 0.0 1.9 2 0 0 2 2 2 0 Spermatogenesis-assoc protein 6 LAP1C PF05609.12 CDI80497.1 - 0.41 9.7 58.8 0.53 9.3 58.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RAP1 PF07218.11 CDI80497.1 - 2.9 6.1 22.6 3.5 5.8 22.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AF-4 PF05110.13 CDI80497.1 - 8.8 4.3 77.1 11 3.9 77.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IMCp PF12314.8 CDI80498.1 - 3.5e-05 24.0 19.8 9.7e-05 22.6 19.8 1.7 1 1 0 1 1 1 1 Inner membrane complex protein Med15 PF09606.10 CDI80498.1 - 1.2 7.7 69.3 2 7.0 69.3 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MAR_sialic_bdg PF10564.9 CDI80499.1 - 4.8e-09 36.1 1.2 9.2e-09 35.2 1.2 1.4 1 0 0 1 1 1 1 Sialic-acid binding micronemal adhesive repeat Methyltr_RsmF_N PF17125.5 CDI80500.1 - 0.0066 16.9 0.3 0.042 14.3 0.1 2.0 1 1 1 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF DUF1307 PF06998.11 CDI80500.1 - 0.015 15.3 0.6 0.07 13.1 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1307) tRNA-synt_1b PF00579.25 CDI80501.1 - 6.2e-48 163.6 0.0 2.5e-31 109.1 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (W and Y) DUF1180 PF06679.12 CDI80501.1 - 2.8 8.3 4.3 4.4 7.7 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) TFIIA PF03153.13 CDI80502.1 - 0.0053 16.8 22.1 0.006 16.6 22.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit FAM183 PF14886.6 CDI80502.1 - 0.047 14.4 11.1 0.047 14.4 11.1 1.5 2 0 0 2 2 1 0 FAM183A and FAM183B related Band_3_cyto PF07565.13 CDI80502.1 - 0.55 10.0 6.4 0.6 9.9 6.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Med15 PF09606.10 CDI80502.1 - 0.64 8.6 27.0 0.71 8.5 27.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 CDI80502.1 - 0.73 9.4 26.1 0.13 11.9 22.6 1.5 2 0 0 2 2 2 0 Spt20 family ABC2_membrane_2 PF12679.7 CDI80502.1 - 1.1 8.5 2.1 1.3 8.2 2.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Presenilin PF01080.17 CDI80502.1 - 1.2 7.8 12.9 1.5 7.5 12.9 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 CDI80502.1 - 1.2 8.1 7.4 1.4 7.9 7.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 CDI80502.1 - 1.5 5.8 7.5 1.6 5.7 7.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GET2 PF08690.10 CDI80502.1 - 1.6 8.4 18.6 2.9 7.5 18.6 1.5 1 1 0 1 1 1 0 GET complex subunit GET2 Serinc PF03348.15 CDI80502.1 - 1.9 7.3 6.3 0.26 10.2 2.4 1.5 2 0 0 2 2 2 0 Serine incorporator (Serinc) V_ATPase_I PF01496.19 CDI80502.1 - 2.7 5.8 7.5 3.5 5.4 7.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAT1 PF09770.9 CDI80502.1 - 2.7 6.1 20.8 2.9 6.0 20.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.14 CDI80502.1 - 3 7.8 12.1 3.6 7.5 12.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CLN3 PF02487.17 CDI80502.1 - 3.6 6.5 5.1 4.7 6.2 5.1 1.1 1 0 0 1 1 1 0 CLN3 protein Hid1 PF12722.7 CDI80502.1 - 3.6 5.6 10.5 3.5 5.6 10.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3086 PF11285.8 CDI80502.1 - 4.4 6.3 12.0 4.7 6.2 11.7 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3086) Ndc1_Nup PF09531.10 CDI80502.1 - 8.7 4.9 10.8 9 4.8 10.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Cupin_1 PF00190.22 CDI80504.1 - 9.6e-06 25.3 0.0 3e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CDI80504.1 - 0.00023 20.8 0.0 0.00044 19.9 0.0 1.4 1 0 0 1 1 1 1 Cupin domain PTP_tm PF18861.1 CDI80505.1 - 0.15 12.1 0.8 1.4 8.9 0.2 2.3 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF4448 PF14610.6 CDI80505.1 - 0.15 11.8 0.2 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Syndecan PF01034.20 CDI80505.1 - 0.22 11.5 0.6 0.58 10.1 0.1 1.9 2 0 0 2 2 2 0 Syndecan domain Glycophorin_A PF01102.18 CDI80505.1 - 0.31 11.3 0.0 0.31 11.3 0.0 2.5 3 1 1 4 4 4 0 Glycophorin A DUF1387 PF07139.11 CDI80505.1 - 7.2 6.3 9.3 10 5.7 9.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) LptF_LptG PF03739.14 CDI80506.1 - 0.00071 18.5 0.1 0.00071 18.5 0.1 2.1 2 1 0 2 2 2 1 Lipopolysaccharide export system permease LptF/LptG RskA PF10099.9 CDI80506.1 - 1.3 9.2 0.0 0.24 11.7 6.4 9.9 5 2 3 8 8 8 0 Anti-sigma-K factor rskA Cu_amine_oxid PF01179.20 CDI80507.1 - 4.5e-74 249.8 0.8 4.5e-74 249.8 0.8 1.9 2 1 0 2 2 2 1 Copper amine oxidase, enzyme domain DFRP_C PF16543.5 CDI80507.1 - 0.0064 17.0 0.6 0.012 16.1 0.6 1.4 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 SMC_Nse1 PF07574.13 CDI80507.1 - 0.012 15.6 1.3 0.019 14.9 1.3 1.3 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex DUF1965 PF09248.10 CDI80507.1 - 0.014 15.2 0.1 0.041 13.7 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) Spt20 PF12090.8 CDI80507.1 - 0.02 14.5 11.0 0.028 14.0 11.0 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI80507.1 - 0.024 14.7 8.2 0.032 14.3 8.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI80507.1 - 0.049 12.6 7.0 0.066 12.1 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF945 PF06097.11 CDI80507.1 - 0.12 11.4 4.0 0.23 10.5 4.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) DUF3452 PF11934.8 CDI80507.1 - 0.2 11.2 2.8 0.33 10.5 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) Androgen_recep PF02166.16 CDI80507.1 - 0.46 9.3 9.1 0.73 8.6 9.1 1.2 1 0 0 1 1 1 0 Androgen receptor SurA_N_2 PF13623.6 CDI80507.1 - 6.6 6.6 14.1 12 5.7 14.1 1.3 1 0 0 1 1 1 0 SurA N-terminal domain Sin_N PF04801.13 CDI80508.1 - 0.001 18.4 24.1 0.001 18.4 24.1 3.5 3 1 0 3 3 3 1 Sin-like protein conserved region Spt20 PF12090.8 CDI80508.1 - 0.012 15.2 27.1 0.012 15.2 27.1 6.5 4 2 1 5 5 5 0 Spt20 family Raffinose_syn PF05691.12 CDI80508.1 - 0.027 12.3 0.0 0.038 11.8 0.0 1.2 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 Glt_symporter PF03616.14 CDI80508.1 - 0.14 10.8 0.0 0.14 10.8 0.0 1.8 2 0 0 2 2 2 0 Sodium/glutamate symporter DcuC PF03606.15 CDI80508.1 - 6.1 5.2 5.9 2.2 6.6 1.8 2.1 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier DUF2722 PF10846.8 CDI80509.1 - 4.9e-05 22.5 5.6 4.9e-05 22.5 5.6 5.4 4 1 1 5 5 3 1 Protein of unknown function (DUF2722) Neur_chan_memb PF02932.16 CDI80509.1 - 0.0029 17.7 4.2 0.0029 17.7 4.2 3.7 4 0 0 4 4 4 1 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 CDI80509.1 - 0.0073 16.0 17.7 0.0073 16.0 17.7 6.1 5 2 0 5 5 3 1 Spt20 family DAG_kinase_N PF14513.6 CDI80509.1 - 0.0077 16.5 3.2 0.0077 16.5 3.2 3.7 4 1 0 4 4 3 1 Diacylglycerol kinase N-terminus OATP PF03137.20 CDI80509.1 - 0.0091 14.3 9.6 0.085 11.1 2.7 2.4 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family SID-1_RNA_chan PF13965.6 CDI80509.1 - 0.015 13.7 5.0 0.017 13.5 1.5 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Raffinose_syn PF05691.12 CDI80509.1 - 0.018 12.8 0.0 0.029 12.2 0.0 1.2 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 CSG2 PF16965.5 CDI80509.1 - 0.035 13.1 11.6 0.012 14.6 4.3 2.3 2 0 0 2 2 2 0 Ceramide synthase regulator Glycos_transf_2 PF00535.26 CDI80509.1 - 0.041 13.7 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Otopetrin PF03189.13 CDI80509.1 - 0.067 12.0 7.2 0.067 12.0 1.5 2.3 2 0 0 2 2 2 0 Otopetrin Connexin PF00029.19 CDI80509.1 - 0.077 12.7 18.6 0.1 12.4 9.2 2.6 2 0 0 2 2 2 0 Connexin TT_ORF1 PF02956.14 CDI80509.1 - 0.12 11.0 11.1 0.3 9.7 3.9 2.3 2 0 0 2 2 2 0 TT viral orf 1 Ureide_permease PF07168.11 CDI80509.1 - 0.21 10.3 11.9 0.083 11.6 2.9 2.8 2 0 0 2 2 2 0 Ureide permease FHIPEP PF00771.20 CDI80509.1 - 0.24 9.9 14.9 0.88 8.0 5.3 2.7 2 0 0 2 2 2 0 FHIPEP family Cyclin_C_2 PF16899.5 CDI80509.1 - 0.29 11.6 5.2 0.17 12.3 1.9 2.4 2 0 0 2 2 1 0 Cyclin C-terminal domain V_ATPase_I PF01496.19 CDI80509.1 - 0.38 8.6 23.4 0.45 8.4 14.0 2.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI80509.1 - 0.65 9.0 17.4 0.15 11.1 7.3 2.5 2 0 0 2 2 2 0 CLN3 protein Serinc PF03348.15 CDI80509.1 - 1.9 7.3 15.4 0.15 10.9 4.6 2.5 2 0 0 2 2 2 0 Serine incorporator (Serinc) TYW3 PF02676.14 CDI80509.1 - 2.7 7.3 11.4 2 7.7 2.7 3.5 3 0 0 3 3 3 0 Methyltransferase TYW3 DUF1980 PF09323.10 CDI80509.1 - 2.9 7.8 22.4 0.017 15.0 4.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1980) SpoIIP PF07454.11 CDI80509.1 - 3.5 7.0 32.7 0.056 12.9 12.6 2.8 3 0 0 3 3 2 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI80509.1 - 4.3 6.3 28.2 0.0062 15.6 6.8 3.1 4 0 0 4 4 4 0 Solute carrier family 12 DUF1943 PF09172.11 CDI80509.1 - 5.2 6.2 8.5 1.1 8.4 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) EOS1 PF12326.8 CDI80509.1 - 6.7 6.6 15.9 0.47 10.4 1.5 3.3 4 0 0 4 4 4 0 N-glycosylation protein MecA PF05389.12 CDI80509.1 - 7.9 6.0 25.8 0.81 9.3 2.9 3.2 4 0 0 4 4 4 0 Negative regulator of genetic competence (MecA) Ctr PF04145.15 CDI80509.1 - 8.5 7.0 20.8 4.5 7.9 6.1 4.0 4 0 0 4 4 4 0 Ctr copper transporter family PQQ_3 PF13570.6 CDI80510.1 - 0.031 14.8 0.6 0.87 10.2 0.0 3.2 2 0 0 2 2 2 0 PQQ-like domain Macoilin PF09726.9 CDI80511.1 - 0.0018 16.9 12.1 0.0018 16.9 12.1 4.4 3 1 0 4 4 4 1 Macoilin family F-box PF00646.33 CDI80511.1 - 0.022 14.6 1.5 0.069 13.1 1.5 1.9 1 0 0 1 1 1 0 F-box domain MLANA PF14991.6 CDI80511.1 - 0.34 11.2 0.0 0.34 11.2 0.0 3.7 4 0 0 4 4 4 0 Protein melan-A DFRP_C PF16543.5 CDI80512.1 - 0.015 15.8 1.5 0.02 15.4 0.3 1.9 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Cnd1 PF12717.7 CDI80513.1 - 5.4e-12 46.1 0.0 0.089 12.8 0.1 6.5 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDI80513.1 - 9.3e-07 27.8 11.2 0.27 9.7 3.5 5.6 3 1 0 5 5 5 3 Adaptin N terminal region HEAT PF02985.22 CDI80513.1 - 9.6e-07 28.6 73.9 6e-05 23.0 0.2 16.6 17 0 0 17 17 17 4 HEAT repeat HEAT_2 PF13646.6 CDI80513.1 - 9.1e-06 26.0 24.2 0.00011 22.5 2.4 14.4 9 5 4 15 15 15 5 HEAT repeats Vac14_Fab1_bd PF12755.7 CDI80513.1 - 5.3e-05 23.7 0.0 1.8 9.2 0.0 5.8 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 CDI80513.1 - 0.0026 17.9 10.0 0.44 10.7 0.1 6.0 6 0 0 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 PalH PF08733.10 CDI80513.1 - 0.025 13.6 1.8 0.049 12.6 1.8 1.4 1 0 0 1 1 1 0 PalH/RIM21 Peptidase_M16_C PF05193.21 CDI80513.1 - 0.18 11.8 3.9 4.5 7.2 0.3 3.8 4 0 0 4 4 4 0 Peptidase M16 inactive domain UME PF08064.13 CDI80513.1 - 0.21 11.5 25.5 0.27 11.2 0.3 8.0 7 1 1 8 8 8 0 UME (NUC010) domain Sporozoite_P67 PF05642.11 CDI80513.1 - 3.6 5.5 17.6 0.028 12.5 0.1 3.3 3 0 0 3 3 3 0 Sporozoite P67 surface antigen Kelch_4 PF13418.6 CDI80514.1 - 5.3e-20 71.2 0.2 0.00018 21.5 0.0 6.8 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI80514.1 - 5.3e-17 61.7 0.9 0.0075 16.5 0.0 7.8 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI80514.1 - 1.4e-15 56.8 0.0 4.4e-07 29.7 0.0 5.8 6 0 0 6 6 6 2 Kelch motif Ras PF00071.22 CDI80514.1 - 1.9e-14 53.6 2.3 2.7e-08 33.6 0.2 2.3 1 1 1 2 2 2 2 Ras family Kelch_6 PF13964.6 CDI80514.1 - 2.8e-11 43.3 0.0 5.6e-05 23.3 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 CDI80514.1 - 1.9e-08 33.9 2.2 0.12 12.4 0.0 5.2 5 0 0 5 5 5 2 Kelch motif RsgA_GTPase PF03193.16 CDI80514.1 - 8.5e-06 25.8 0.8 0.091 12.7 0.4 2.4 1 1 1 2 2 2 2 RsgA GTPase Roc PF08477.13 CDI80514.1 - 8.6e-06 26.0 0.1 2e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Kelch_1 PF01344.25 CDI80514.1 - 1.5e-05 24.5 0.4 0.0031 17.1 0.0 4.1 5 0 0 5 5 5 1 Kelch motif NACHT PF05729.12 CDI80514.1 - 0.0054 16.7 0.1 0.013 15.5 0.1 1.7 1 0 0 1 1 1 1 NACHT domain Sigma54_activat PF00158.26 CDI80514.1 - 0.065 12.9 0.1 0.17 11.6 0.1 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain TniB PF05621.11 CDI80514.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Septin PF00735.18 CDI80514.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Septin Arf PF00025.21 CDI80514.1 - 0.16 11.4 0.5 2.6 7.4 0.1 2.2 1 1 1 2 2 2 0 ADP-ribosylation factor family AAA_7 PF12775.7 CDI80514.1 - 0.21 11.1 0.0 0.42 10.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AP2 PF00847.20 CDI80515.1 - 4.5e-06 26.8 1.4 4.5e-06 26.8 1.4 3.4 2 0 0 2 2 2 1 AP2 domain Cyt_bd_oxida_II PF02322.15 CDI80516.1 - 1.7 7.9 4.7 5.3 6.3 4.7 1.8 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II CCSAP PF15748.5 CDI80517.1 - 0.001 19.3 19.1 0.001 19.3 19.1 4.7 3 2 0 3 3 3 1 Centriole, cilia and spindle-associated RNA_pol_Rpc4 PF05132.14 CDI80517.1 - 0.0049 17.3 6.6 0.0049 17.3 6.6 6.2 7 1 1 8 8 8 1 RNA polymerase III RPC4 DUF3402 PF11882.8 CDI80518.1 - 0.0058 15.8 5.5 0.0058 15.8 5.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3402) SARAF PF06682.12 CDI80518.1 - 0.0061 16.3 25.7 0.0061 16.2 24.9 1.4 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SLC12 PF03522.15 CDI80518.1 - 0.087 11.8 18.0 0.12 11.4 18.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI80518.1 - 0.2 9.9 32.4 0.23 9.7 32.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Afi1 PF07792.12 CDI80518.1 - 0.27 11.7 16.9 0.75 10.3 7.4 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Med15 PF09606.10 CDI80518.1 - 0.5 9.0 54.2 0.71 8.5 54.2 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CRT10 PF08728.10 CDI80518.1 - 0.5 8.5 6.7 0.56 8.3 6.7 1.0 1 0 0 1 1 1 0 CRT10 Hid1 PF12722.7 CDI80518.1 - 2.1 6.4 21.1 2.7 6.0 21.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CSG2 PF16965.5 CDI80518.1 - 3.7 6.4 12.9 0.18 10.7 3.5 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator CDC45 PF02724.14 CDI80518.1 - 5.9 5.1 19.4 9.3 4.4 19.4 1.3 1 0 0 1 1 1 0 CDC45-like protein CDK5_activator PF03261.15 CDI80518.1 - 6.1 6.3 18.0 8.3 5.9 18.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SID-1_RNA_chan PF13965.6 CDI80518.1 - 8.1 4.7 11.7 0.54 8.6 3.1 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Peptidase_S64 PF08192.11 CDI80518.1 - 8.2 4.8 20.8 12 4.2 20.8 1.2 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI80519.1 - 0.0019 18.6 4.1 0.0024 18.2 4.1 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI80519.1 - 0.043 13.4 30.7 0.051 13.2 30.7 1.0 1 0 0 1 1 1 0 Spt20 family Paf1 PF03985.13 CDI80519.1 - 0.06 12.4 22.0 0.071 12.1 22.0 1.0 1 0 0 1 1 1 0 Paf1 GREB1 PF15782.5 CDI80519.1 - 0.081 10.1 19.1 0.086 10.0 19.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 CDI80519.1 - 0.09 12.3 19.3 0.1 12.1 19.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 CDI80519.1 - 0.13 10.8 19.1 0.16 10.5 19.1 1.1 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 CDI80519.1 - 0.14 11.7 37.0 0.22 11.1 37.1 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4718 PF15842.5 CDI80519.1 - 0.18 11.6 11.5 0.2 11.4 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) AF-4 PF05110.13 CDI80519.1 - 0.2 9.7 31.0 0.23 9.5 31.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Menin PF05053.13 CDI80519.1 - 0.21 9.9 13.2 0.26 9.6 13.2 1.1 1 0 0 1 1 1 0 Menin PI3K_1B_p101 PF10486.9 CDI80519.1 - 0.24 9.1 14.4 0.28 8.9 14.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TFIIA PF03153.13 CDI80519.1 - 0.25 11.3 27.9 0.3 11.0 27.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Vfa1 PF08432.10 CDI80519.1 - 0.27 11.6 14.2 0.32 11.3 14.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Plasmodium_Vir PF05795.11 CDI80519.1 - 0.27 10.6 11.4 0.29 10.5 11.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MMR1 PF08505.10 CDI80519.1 - 0.31 11.3 21.6 0.35 11.1 21.6 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Zip PF02535.22 CDI80519.1 - 0.33 10.1 9.8 0.35 10.0 9.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MPM1 PF17234.2 CDI80519.1 - 0.33 11.2 17.6 0.41 10.9 17.6 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SARAF PF06682.12 CDI80519.1 - 0.35 10.5 18.9 0.52 9.9 18.9 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Miga PF10265.9 CDI80519.1 - 0.4 9.6 15.5 0.43 9.5 15.5 1.0 1 0 0 1 1 1 0 Mitoguardin Apt1 PF10351.9 CDI80519.1 - 0.49 9.2 22.9 0.57 9.0 22.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Kinesin_assoc PF16183.5 CDI80519.1 - 0.5 10.5 5.3 0.61 10.2 5.3 1.1 1 0 0 1 1 1 0 Kinesin-associated FAM60A PF15396.6 CDI80519.1 - 0.53 10.3 12.2 0.66 10.0 12.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Piezo_RRas_bdg PF12166.8 CDI80519.1 - 0.54 9.5 9.0 0.61 9.3 9.0 1.0 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain BORG_CEP PF14957.6 CDI80519.1 - 0.58 11.3 14.5 0.67 11.1 14.5 1.1 1 0 0 1 1 1 0 Cdc42 effector HSD3 PF15244.6 CDI80519.1 - 0.68 9.4 16.5 0.8 9.2 16.5 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 DUF1645 PF07816.11 CDI80519.1 - 0.76 10.3 20.1 0.96 10.0 20.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Herpes_pp85 PF04637.12 CDI80519.1 - 0.77 8.1 8.8 0.84 8.0 8.8 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF2151 PF10221.9 CDI80519.1 - 0.78 8.3 10.8 0.86 8.1 10.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF1635 PF07795.11 CDI80519.1 - 0.93 9.3 17.4 1.4 8.8 17.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Mem_trans PF03547.18 CDI80519.1 - 1 7.7 13.1 1.1 7.5 13.1 1.0 1 0 0 1 1 1 0 Membrane transport protein Peptidase_S64 PF08192.11 CDI80519.1 - 1.6 7.2 22.5 1.8 7.0 22.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 SRP-alpha_N PF04086.13 CDI80519.1 - 1.9 8.3 19.5 2.3 8.0 19.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ribosomal_60s PF00428.19 CDI80519.1 - 2 9.0 7.4 4.9 7.8 7.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Sporozoite_P67 PF05642.11 CDI80519.1 - 2.1 6.3 15.0 2.4 6.1 15.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen XAP5 PF04921.14 CDI80519.1 - 2.5 7.9 13.1 3.1 7.5 13.1 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator SAPS PF04499.15 CDI80519.1 - 2.6 6.7 12.4 2.7 6.7 12.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CDI80519.1 - 2.8 6.6 23.9 3.1 6.5 23.9 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CDI80519.1 - 3 6.0 18.8 3.6 5.8 18.8 1.0 1 0 0 1 1 1 0 CDC45-like protein CAML PF14963.6 CDI80519.1 - 3.4 7.7 9.8 4.5 7.3 9.8 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand FAM76 PF16046.5 CDI80519.1 - 3.4 7.0 17.7 4 6.7 17.7 1.1 1 0 0 1 1 1 0 FAM76 protein SLC12 PF03522.15 CDI80519.1 - 3.6 6.5 16.6 4.1 6.3 16.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CPSF100_C PF13299.6 CDI80519.1 - 3.8 7.7 13.5 5.3 7.2 13.5 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CDI80519.1 - 4.1 7.1 15.7 4.6 7.0 15.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CDI80519.1 - 4.7 6.1 10.7 5.5 5.9 10.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Chorion_2 PF03964.15 CDI80519.1 - 4.7 8.1 28.6 0.046 14.5 15.9 2.1 1 1 1 2 2 1 0 Chorion family 2 DDHD PF02862.17 CDI80519.1 - 5 7.2 16.6 7.6 6.6 16.6 1.4 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 CDI80519.1 - 5.7 5.1 18.2 5.8 5.0 18.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CLN3 PF02487.17 CDI80519.1 - 5.9 5.8 10.5 6.8 5.6 10.5 1.1 1 0 0 1 1 1 0 CLN3 protein CobT PF06213.12 CDI80519.1 - 6.4 6.1 25.6 7.6 5.8 25.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paramyxo_ncap PF00973.19 CDI80519.1 - 6.4 5.6 13.4 7.2 5.4 13.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein VIR_N PF15912.5 CDI80519.1 - 6.9 6.2 10.0 8 6.0 10.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal MMU163 PF17119.5 CDI80519.1 - 6.9 5.7 13.9 8.4 5.5 13.9 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis RAP1 PF07218.11 CDI80519.1 - 8.3 4.6 18.1 9.4 4.4 18.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4637 PF15470.6 CDI80519.1 - 9.2 6.0 15.7 12 5.6 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sec62 PF03839.16 CDI80519.1 - 9.3 5.7 9.4 11 5.4 9.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SPX PF03105.19 CDI80519.1 - 9.5 6.0 23.8 11 5.8 23.8 1.0 1 0 0 1 1 1 0 SPX domain Neur_chan_memb PF02932.16 CDI80519.1 - 9.6 6.2 11.4 11 6.0 11.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ANAPC4_WD40 PF12894.7 CDI80520.1 - 2.2e-11 43.9 0.4 0.024 14.9 0.0 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI80520.1 - 2.2e-10 40.9 3.2 0.0048 17.7 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CDI80520.1 - 0.043 12.8 0.0 0.091 11.7 0.0 1.5 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CRAL_TRIO PF00650.20 CDI80523.1 - 4.6e-09 36.2 0.0 6.4e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Ni_hydr_CYTB PF01292.20 CDI80524.1 - 0.48 10.0 6.8 0.26 10.9 4.4 1.8 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 SIT PF15330.6 CDI80525.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Insulin_TMD PF17870.1 CDI80525.1 - 0.26 11.4 0.9 0.42 10.7 0.9 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF676 PF05057.14 CDI80527.1 - 4.7e-22 78.6 0.0 1.3e-21 77.1 0.0 1.8 1 1 1 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CDI80527.1 - 3.2e-07 31.2 3.5 3.2e-07 31.2 3.5 3.5 4 0 0 4 4 4 1 Alpha/beta hydrolase family DUF3657 PF12394.8 CDI80527.1 - 0.0086 16.6 0.7 0.0086 16.6 0.7 5.2 5 1 0 5 5 5 1 Protein FAM135 Abhydrolase_1 PF00561.20 CDI80527.1 - 0.014 15.1 0.1 0.014 15.1 0.1 3.7 5 0 0 5 5 5 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 CDI80527.1 - 0.017 15.0 0.0 0.054 13.4 0.0 1.8 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 CDI80527.1 - 0.021 14.6 1.7 0.1 12.3 0.1 3.0 2 1 0 2 2 2 0 PGAP1-like protein RRM_1 PF00076.22 CDI80528.1 - 0.028 14.2 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Shisa PF13908.6 CDI80528.1 - 0.13 12.5 6.1 0.19 12.0 6.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Apt1 PF10351.9 CDI80528.1 - 2 7.2 5.7 2.2 7.1 5.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI80528.1 - 6.9 5.1 9.2 8.9 4.7 9.2 1.2 1 0 0 1 1 1 0 Macoilin family PPDK_N PF01326.19 CDI80530.1 - 9.7e-07 28.4 0.0 0.037 13.3 0.0 2.3 2 1 0 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain XAF1_C PF18608.1 CDI80530.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain SNRNP27 PF08648.12 CDI80531.1 - 4.6e-26 90.7 0.4 4.6e-26 90.7 0.4 2.4 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins RRM_1 PF00076.22 CDI80531.1 - 1.5e-20 72.8 0.2 3.7e-20 71.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 CDI80531.1 - 8e-14 52.1 3.1 8e-14 52.1 3.1 3.2 4 0 0 4 4 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SUIM_assoc PF16619.5 CDI80531.1 - 0.0016 18.5 2.9 0.0016 18.5 2.9 3.1 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 DUF2076 PF09849.9 CDI80531.1 - 0.002 18.2 12.2 0.0032 17.6 12.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Spt20 PF12090.8 CDI80531.1 - 0.0096 15.6 7.1 0.018 14.7 7.1 1.4 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI80531.1 - 0.027 14.5 9.5 0.049 13.6 9.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 CDI80531.1 - 0.028 13.8 5.9 0.046 13.1 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_60s PF00428.19 CDI80531.1 - 0.046 14.3 4.5 0.11 13.2 4.5 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF1904 PF08921.11 CDI80531.1 - 0.064 13.6 0.9 0.11 12.8 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) RRM_7 PF16367.5 CDI80531.1 - 0.094 12.8 0.5 1 9.5 0.0 2.8 3 1 0 3 3 3 0 RNA recognition motif Presenilin PF01080.17 CDI80531.1 - 0.24 10.1 4.5 0.39 9.4 4.5 1.3 1 0 0 1 1 1 0 Presenilin AP2 PF00847.20 CDI80532.1 - 4e-06 27.0 0.9 4e-06 27.0 0.9 5.4 6 0 0 6 6 6 1 AP2 domain DUF3371 PF11851.8 CDI80532.1 - 0.008 17.3 10.4 0.008 17.3 10.4 12.5 8 4 0 8 8 8 1 Domain of unknown function (DUF3371) Cu-binding_MopE PF11617.8 CDI80532.1 - 0.085 13.0 1.7 0.22 11.7 1.7 1.7 1 0 0 1 1 1 0 Putative metal-binding motif Prominin PF05478.11 CDI80534.1 - 0.01 13.8 0.3 0.012 13.6 0.3 1.1 1 0 0 1 1 1 0 Prominin N2227 PF07942.12 CDI80534.1 - 0.037 13.2 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 N2227-like protein Apolipoprotein PF01442.18 CDI80534.1 - 0.064 13.1 0.0 0.3 11.0 0.0 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain GTP_EFTU PF00009.27 CDI80536.1 - 6.9e-58 195.4 0.0 9e-58 195.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDI80536.1 - 6.1e-24 84.5 0.0 1.2e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDI80536.1 - 1.9e-11 44.2 0.0 4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDI80536.1 - 6.4e-05 23.0 0.1 0.00011 22.3 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI80536.1 - 0.086 12.7 0.0 0.2 11.6 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 CDI80536.1 - 0.11 12.0 0.4 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mqo PF06039.15 CDI80537.1 - 4.2e-06 25.6 0.0 5.5e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 CDI80537.1 - 8e-06 25.7 0.0 1e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDI80537.1 - 0.0038 16.5 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Flavodoxin_5 PF12724.7 CDI80537.1 - 0.022 15.0 0.0 0.028 14.6 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin domain NAD_binding_8 PF13450.6 CDI80537.1 - 0.038 14.2 0.1 0.076 13.3 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CDI80537.1 - 0.084 12.2 0.2 0.16 11.3 0.1 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PGI PF00342.19 CDI80540.1 - 5.2e-189 628.9 0.0 6.2e-189 628.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Peptidase_S8 PF00082.22 CDI80544.1 - 1.9e-33 116.0 3.8 1.9e-33 116.0 3.8 5.0 4 2 0 4 4 4 1 Subtilase family BSP_II PF05432.11 CDI80545.1 - 0.2 11.3 1.5 0.3 10.7 1.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NAP PF00956.18 CDI80546.1 - 1.2e-68 231.2 0.5 2.2e-68 230.3 0.5 1.4 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Phage_Nu1 PF07471.12 CDI80546.1 - 1.5 8.6 4.6 21 4.8 0.8 2.9 2 1 1 3 3 3 0 Phage DNA packaging protein Nu1 NOA36 PF06524.12 CDI80546.1 - 3.4 6.9 8.6 5.5 6.2 8.6 1.3 1 0 0 1 1 1 0 NOA36 protein RNA_pol_L PF01193.24 CDI80547.1 - 9.3e-11 41.0 0.0 2e-10 39.9 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 CDI80547.1 - 5e-06 26.9 0.0 7.7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain HemX PF04375.14 CDI80547.1 - 0.014 14.7 0.5 0.021 14.1 0.5 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase SPX PF03105.19 CDI80547.1 - 0.026 14.4 5.4 0.032 14.2 5.4 1.1 1 0 0 1 1 1 0 SPX domain RPN7 PF10602.9 CDI80548.1 - 4.1e-32 111.3 0.8 6.2e-32 110.7 0.8 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CDI80548.1 - 6.8e-07 29.8 0.0 1.4e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.6 CDI80548.1 - 0.041 13.9 0.0 0.2 11.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4375 PF14300.6 CDI80548.1 - 0.15 12.4 2.6 0.32 11.3 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) NAGLU_C PF12972.7 CDI80548.1 - 0.16 11.5 0.9 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain Adaptin_N PF01602.20 CDI80549.1 - 2.3e-64 217.9 0.0 1e-32 113.4 0.1 2.5 2 1 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 CDI80549.1 - 6.2e-09 36.1 1.7 1.2e-08 35.1 0.1 2.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDI80549.1 - 0.00022 21.6 1.1 0.00022 21.6 1.1 4.7 5 1 1 6 6 6 2 HEAT repeats BLOC1S3 PF15753.5 CDI80549.1 - 0.0045 17.1 2.1 0.0045 17.1 2.1 2.2 3 0 0 3 3 3 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 Spt20 PF12090.8 CDI80549.1 - 0.65 9.6 14.8 1.3 8.5 14.8 1.4 1 0 0 1 1 1 0 Spt20 family HEAT PF02985.22 CDI80549.1 - 2.1 8.8 14.6 9.6 6.8 0.0 6.3 8 0 0 8 8 8 0 HEAT repeat SprA-related PF12118.8 CDI80549.1 - 8.4 5.4 23.9 1.3 8.1 14.4 2.5 2 0 0 2 2 2 0 SprA-related family XPG_I PF00867.18 CDI80550.1 - 8.2e-29 99.8 0.0 2.1e-28 98.5 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CDI80550.1 - 2.2e-25 89.1 0.0 3.6e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 CDI80550.1 - 1.3e-06 28.9 0.0 8.1e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold DUF892 PF05974.12 CDI80550.1 - 0.01 15.9 0.2 0.022 14.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF892) IMUP PF15761.5 CDI80550.1 - 0.038 14.7 6.3 0.093 13.4 6.3 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein CLTH PF10607.9 CDI80552.1 - 3.1e-12 46.6 0.3 1.1e-09 38.3 0.0 2.1 1 1 1 2 2 2 2 CTLH/CRA C-terminal to LisH motif domain DUF1858 PF08984.11 CDI80552.1 - 0.18 12.0 0.2 0.58 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1858) DAGAT PF03982.13 CDI80554.1 - 4.2e-38 130.9 0.0 5.5e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase PLDc_2 PF13091.6 CDI80555.1 - 0.0062 16.4 0.0 0.0095 15.8 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain SUIM_assoc PF16619.5 CDI80555.1 - 0.027 14.5 2.2 0.073 13.1 1.5 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2681 PF10883.8 CDI80555.1 - 0.15 12.5 3.4 0.96 9.9 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Spt20 PF12090.8 CDI80556.1 - 0.0077 15.9 17.4 0.0077 15.9 17.4 3.8 3 1 0 3 3 3 1 Spt20 family DUF3446 PF11928.8 CDI80556.1 - 0.38 11.1 9.4 0.082 13.2 1.4 3.0 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF1682 PF07946.14 CDI80556.1 - 1 8.5 12.9 0.12 11.5 5.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) Serinc PF03348.15 CDI80556.1 - 6 5.7 10.4 0.56 9.1 5.0 1.9 2 0 0 2 2 2 0 Serine incorporator (Serinc) Actin PF00022.19 CDI80559.1 - 2e-44 151.8 0.1 2.5e-36 125.2 0.0 3.2 3 1 0 3 3 3 2 Actin TFIIA PF03153.13 CDI80559.1 - 7.1e-05 23.0 66.7 0.055 13.5 23.4 3.3 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI80559.1 - 0.09 12.9 0.2 0.09 12.9 0.2 7.0 5 1 1 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 SMC_N PF02463.19 CDI80560.1 - 3.7e-26 91.9 14.3 2.8e-25 89.1 14.3 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDI80560.1 - 2.2e-11 44.1 1.6 1.5e-07 31.5 0.1 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 CDI80560.1 - 7.7e-09 35.9 0.1 7.7e-09 35.9 0.1 2.8 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 CDI80560.1 - 1.9e-08 34.4 30.7 0.002 17.9 9.1 4.0 2 2 0 2 2 2 2 AAA ATPase domain SbcCD_C PF13558.6 CDI80560.1 - 0.00043 20.5 1.2 0.00043 20.5 1.2 3.5 4 0 0 4 4 4 1 Putative exonuclease SbcCD, C subunit Ndc1_Nup PF09531.10 CDI80561.1 - 0.00064 18.6 1.8 0.00064 18.6 1.8 6.9 4 2 0 4 4 4 1 Nucleoporin protein Ndc1-Nup Activator_LAG-3 PF11498.8 CDI80561.1 - 0.0036 16.3 7.1 0.0036 16.3 7.1 10.4 7 3 2 9 9 9 2 Transcriptional activator LAG-3 FtsJ PF01728.19 CDI80561.1 - 3.9 7.5 18.3 0.033 14.3 3.1 4.1 2 2 0 2 2 2 0 FtsJ-like methyltransferase G-7-MTase PF12803.7 CDI80562.1 - 0.098 11.8 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) DUF885 PF05960.11 CDI80562.1 - 0.11 12.1 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) PDGLE PF13190.6 CDI80563.1 - 0.066 13.1 0.1 2.4 8.1 0.1 2.5 1 1 0 1 1 1 0 PDGLE domain DCB PF16213.5 CDI80563.1 - 0.18 11.4 0.1 0.74 9.5 0.0 1.9 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 V-SNARE PF05008.15 CDI80563.1 - 0.23 11.8 0.5 0.63 10.5 0.1 2.0 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus UCH PF00443.29 CDI80564.1 - 8e-24 84.5 0.0 7.3e-20 71.5 0.0 3.5 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Radical_SAM_C PF16199.5 CDI80565.1 - 2.9e-17 62.4 0.0 6e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CDI80565.1 - 0.083 13.3 0.0 0.28 11.6 0.0 1.9 1 0 0 1 1 1 0 Radical SAM superfamily tRNA-synt_2 PF00152.20 CDI80566.1 - 3.4e-77 259.6 0.0 4.5e-77 259.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDI80566.1 - 3.5e-10 39.7 0.0 7e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDI80566.1 - 9.7e-08 31.8 0.0 5.7e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) HSP90 PF00183.18 CDI80567.1 - 3.1e-17 62.7 0.1 3.3e-11 42.8 0.0 2.0 1 1 1 2 2 2 2 Hsp90 protein Myosin_head PF00063.21 CDI80568.1 - 6.1e-182 606.4 8.0 8e-182 606.0 8.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.19 CDI80568.1 - 6e-08 32.4 2.1 1.3e-07 31.3 2.1 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 CDI80568.1 - 0.0031 17.9 0.0 0.0085 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDI80568.1 - 0.012 15.9 0.1 0.031 14.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 CDI80568.1 - 0.03 14.4 0.1 0.092 12.8 0.1 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Sigma54_activat PF00158.26 CDI80568.1 - 0.044 13.5 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain SH3_19 PF18597.1 CDI80568.1 - 0.087 12.7 0.3 0.19 11.6 0.3 1.6 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain IQ PF00612.27 CDI80568.1 - 0.14 12.0 9.1 0.53 10.2 0.2 3.6 3 0 0 3 3 3 0 IQ calmodulin-binding motif 2-Hacid_dh_C PF02826.19 CDI80571.1 - 1.9e-11 43.7 0.0 2.7e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDI80571.1 - 0.0031 17.2 0.0 0.73 9.5 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 CDI80571.1 - 0.029 14.9 0.0 0.059 14.0 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AP2 PF00847.20 CDI80573.1 - 3e-09 37.0 0.7 3e-09 37.0 0.7 2.0 2 0 0 2 2 1 1 AP2 domain RskA PF10099.9 CDI80573.1 - 0.00093 19.5 27.8 3.9e+02 1.2 27.8 2.4 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Serinc PF03348.15 CDI80573.1 - 0.0084 15.1 0.8 0.01 14.8 0.8 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) CDC45 PF02724.14 CDI80573.1 - 0.021 13.1 7.7 0.027 12.8 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein LIM_bind PF01803.16 CDI80573.1 - 0.095 12.2 9.0 0.15 11.6 9.0 1.2 1 0 0 1 1 1 0 LIM-domain binding protein NPR3 PF03666.13 CDI80573.1 - 0.15 10.8 9.7 0.17 10.6 9.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_3_cyto PF07565.13 CDI80573.1 - 0.27 11.0 13.7 0.4 10.4 13.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI80573.1 - 0.32 9.7 14.2 0.45 9.2 14.2 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 CDI80573.1 - 0.56 10.6 12.2 0.58 10.6 8.0 2.5 2 1 1 3 3 3 0 RNA polymerase III RPC4 DDHD PF02862.17 CDI80573.1 - 0.74 9.9 11.5 1.2 9.3 11.5 1.3 1 0 0 1 1 1 0 DDHD domain Paf1 PF03985.13 CDI80573.1 - 0.84 8.6 17.6 1 8.3 17.6 1.1 1 0 0 1 1 1 0 Paf1 SID-1_RNA_chan PF13965.6 CDI80573.1 - 0.94 7.8 3.2 1.1 7.6 3.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.12 CDI80573.1 - 1 8.3 6.4 1.4 7.8 6.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EOS1 PF12326.8 CDI80573.1 - 1.1 9.2 2.9 1.5 8.7 2.9 1.3 1 0 0 1 1 1 0 N-glycosylation protein Peptidase_U57 PF05582.12 CDI80573.1 - 1.9 7.7 9.4 2.7 7.2 9.4 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Cellulose_synt PF03552.14 CDI80573.1 - 2.1 6.7 8.1 2.6 6.4 8.1 1.0 1 0 0 1 1 1 0 Cellulose synthase Zip PF02535.22 CDI80573.1 - 2.2 7.4 6.4 3.2 6.9 6.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 CDI80573.1 - 3.4 6.3 4.6 5.4 5.7 4.6 1.4 1 0 0 1 1 1 0 Ureide permease Peptidase_S49_N PF08496.10 CDI80573.1 - 3.5 7.7 15.0 5.4 7.1 15.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Connexin PF00029.19 CDI80573.1 - 4.1 7.1 12.2 5.5 6.7 12.2 1.2 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 CDI80573.1 - 5.5 7.1 12.4 11 6.2 12.4 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 CDI80573.1 - 5.8 5.8 19.2 7.4 5.4 19.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI80573.1 - 7.3 7.6 15.9 17 6.4 15.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3408 PF11888.8 CDI80573.1 - 7.8 6.6 17.2 17 5.5 17.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF3276 PF11680.8 CDI80573.1 - 9.5 6.4 15.6 15 5.7 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) PS_Dcarbxylase PF02666.15 CDI80575.1 - 1.3e-14 54.2 0.1 2.5e-06 27.2 0.0 4.2 3 1 1 4 4 4 3 Phosphatidylserine decarboxylase Apolipoprotein PF01442.18 CDI80575.1 - 1.8e-06 28.0 5.1 4.7e-06 26.6 5.1 1.6 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain IF4E PF01652.18 CDI80576.1 - 4.3e-09 36.4 0.0 7.3e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E VPS13_C PF16909.5 CDI80577.1 - 1.4e-15 57.6 0.0 2.9e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 CDI80577.1 - 5.9e-12 45.7 0.1 1.3e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 CDI80577.1 - 1.1e-09 38.1 0.0 5.7e-07 29.2 0.0 2.8 1 1 1 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 CDI80577.1 - 2.2e-06 27.6 0.0 1.9e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Lin0512_fam PF09585.10 CDI80577.1 - 0.071 13.2 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) Pup_ligase PF03136.15 CDI80578.1 - 0.053 12.5 0.1 0.099 11.6 0.1 1.4 1 0 0 1 1 1 0 Pup-ligase protein RskA PF10099.9 CDI80579.1 - 3.1e-07 30.9 0.0 1.4e-06 28.7 0.0 1.9 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SID-1_RNA_chan PF13965.6 CDI80579.1 - 0.019 13.4 5.1 0.025 13.0 5.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ANAPC_CDC26 PF10471.9 CDI80579.1 - 0.044 14.6 0.7 0.044 14.6 0.7 4.0 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 SNF2_N PF00176.23 CDI80581.1 - 8.1e-30 103.7 4.4 1.2e-22 80.1 0.0 3.3 4 0 0 4 4 4 2 SNF2 family N-terminal domain ANAPC1 PF12859.7 CDI80581.1 - 0.011 16.3 2.9 0.072 13.7 0.5 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 ResIII PF04851.15 CDI80581.1 - 0.035 14.1 0.3 0.099 12.6 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF4800 PF16057.5 CDI80581.1 - 0.26 10.5 12.0 0.014 14.7 3.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4800) F_actin_cap_B PF01115.17 CDI80583.1 - 4.9e-21 75.4 0.0 5.5e-21 75.3 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit DUF2034 PF10356.9 CDI80584.1 - 0.011 15.2 0.2 0.034 13.6 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2034) MTABC_N PF16185.5 CDI80584.1 - 0.2 11.1 1.7 1.5 8.2 0.2 2.7 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region EzrA PF06160.12 CDI80588.1 - 8.5e-05 20.9 10.4 8.5e-05 20.9 10.4 2.0 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA Spc7 PF08317.11 CDI80588.1 - 0.0015 17.5 11.7 0.0015 17.5 11.7 3.1 2 1 1 3 3 3 1 Spc7 kinetochore protein BLOC1_2 PF10046.9 CDI80588.1 - 0.0037 17.5 19.9 0.84 10.0 0.4 4.9 2 2 3 5 5 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 NuiA PF07924.11 CDI80588.1 - 0.056 13.8 3.2 0.56 10.6 0.1 3.1 1 1 2 3 3 3 0 Nuclease A inhibitor-like protein Baculo_PEP_C PF04513.12 CDI80588.1 - 0.06 13.4 11.4 3.2 7.8 5.2 3.5 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CDI80588.1 - 0.13 12.3 19.0 0.064 13.3 5.6 4.4 3 2 3 6 6 5 0 Protein of unknown function (DUF1664) KR PF08659.10 CDI80588.1 - 0.13 12.1 2.8 1.2 9.1 0.5 2.6 2 0 0 2 2 2 0 KR domain Occludin_ELL PF07303.13 CDI80588.1 - 0.35 11.6 11.5 18 6.1 0.3 4.4 3 2 1 4 4 4 0 Occludin homology domain GAS PF13851.6 CDI80588.1 - 0.36 10.1 27.8 0.025 13.9 13.0 3.9 2 2 0 3 3 3 0 Growth-arrest specific micro-tubule binding MAD PF05557.13 CDI80588.1 - 0.68 8.2 31.6 0.91 7.8 15.1 3.4 2 2 0 2 2 2 0 Mitotic checkpoint protein ApoB100_C PF12491.8 CDI80588.1 - 1.1 9.3 5.2 4.2 7.4 0.1 3.4 4 0 0 4 4 4 0 Apolipoprotein B100 C terminal PspB PF06667.12 CDI80588.1 - 1.1 9.3 5.7 5.1 7.2 2.1 3.3 2 0 0 2 2 2 0 Phage shock protein B DUF16 PF01519.16 CDI80588.1 - 1.6 9.3 14.8 3.2 8.3 3.1 3.8 3 1 0 3 3 3 0 Protein of unknown function DUF16 GldM_N PF12081.8 CDI80588.1 - 1.9 8.5 9.7 0.18 11.9 2.0 2.8 2 1 0 3 3 3 0 GldM N-terminal domain Laminin_II PF06009.12 CDI80588.1 - 3.9 7.5 19.0 2.2 8.3 0.2 3.8 2 2 2 4 4 4 0 Laminin Domain II RPW8 PF05659.11 CDI80588.1 - 4.1 7.1 9.9 0.29 10.8 1.1 3.5 3 3 2 5 5 5 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Sec34 PF04136.15 CDI80588.1 - 4.2 7.2 13.8 5 7.0 0.2 3.0 2 1 1 3 3 3 0 Sec34-like family Syntaxin-6_N PF09177.11 CDI80588.1 - 4.3 8.0 18.5 0.13 12.9 5.8 3.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal MDMPI_N PF11716.8 CDI80588.1 - 5.5 7.7 10.0 14 6.4 0.2 3.0 3 0 0 3 3 3 0 Mycothiol maleylpyruvate isomerase N-terminal domain ATG16 PF08614.11 CDI80588.1 - 5.9 7.1 32.6 0.21 11.8 17.0 3.3 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) DivIVA PF05103.13 CDI80588.1 - 5.9 7.0 21.8 2.8 8.0 7.2 4.1 3 1 1 4 4 4 0 DivIVA protein DUF2203 PF09969.9 CDI80588.1 - 8.3 7.1 20.6 0.85 10.4 3.4 4.4 2 2 3 5 5 5 0 Uncharacterized conserved protein (DUF2203) ERM PF00769.19 CDI80588.1 - 9.4 6.0 35.0 0.14 11.9 15.7 2.4 2 1 0 2 2 2 0 Ezrin/radixin/moesin family WD40 PF00400.32 CDI80589.1 - 2.1e-22 79.0 23.6 9.5e-05 23.1 1.3 10.6 11 0 0 11 11 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI80589.1 - 5.3e-14 52.3 0.0 0.023 15.0 0.0 6.3 6 1 1 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDI80589.1 - 2.2e-06 26.9 0.2 0.01 14.8 0.0 4.4 4 2 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CDI80589.1 - 1.4e-05 25.4 2.7 2.9 8.5 0.0 6.7 7 0 0 7 7 7 1 PQQ-like domain PQQ_2 PF13360.6 CDI80589.1 - 0.00011 21.9 0.1 0.023 14.3 0.0 3.0 1 1 2 3 3 3 3 PQQ-like domain PD40 PF07676.12 CDI80589.1 - 0.0077 16.1 0.0 7.9 6.5 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 CDI80589.1 - 0.012 14.2 0.7 0.18 10.5 0.2 2.7 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Glyco_hydro_77 PF02446.17 CDI80590.1 - 1.4e-50 172.6 0.1 2.1e-50 171.9 0.1 1.2 1 1 0 1 1 1 1 4-alpha-glucanotransferase CNDH2_C PF16858.5 CDI80593.1 - 1.3 8.8 29.3 1.7 8.5 5.2 3.6 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Ins_P5_2-kin PF06090.12 CDI80594.1 - 5.5e-09 35.9 9.3 5.5e-09 35.9 9.3 3.7 1 1 0 2 2 2 1 Inositol-pentakisphosphate 2-kinase Zip PF02535.22 CDI80594.1 - 0.0019 17.5 2.3 0.0019 17.5 2.3 2.4 2 0 0 2 2 2 2 ZIP Zinc transporter tRNA_m1G_MT PF01746.21 CDI80595.1 - 8.6e-18 64.7 0.1 2.4e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase ANAPC3 PF12895.7 CDI80596.1 - 0.0027 17.9 5.6 1.2 9.4 0.1 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDI80596.1 - 0.035 14.8 3.6 18 6.3 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI80596.1 - 0.045 14.3 2.3 14 6.3 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDI80596.1 - 0.14 12.9 5.2 0.67 10.6 1.9 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI80596.1 - 0.35 11.1 5.3 24 5.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat DSPc PF00782.20 CDI80598.1 - 0.16 11.7 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain WD40 PF00400.32 CDI80599.1 - 6.5e-09 36.3 7.3 0.00022 22.0 3.7 3.5 2 1 0 2 2 2 2 WD domain, G-beta repeat CagY_I PF14585.6 CDI80600.1 - 0.023 14.8 1.0 0.066 13.3 1.0 1.8 1 0 0 1 1 1 0 CagY type 1 repeat Macoilin PF09726.9 CDI80600.1 - 0.048 12.2 20.4 0.058 11.9 20.4 1.2 1 0 0 1 1 1 0 Macoilin family BLOC1_2 PF10046.9 CDI80600.1 - 0.11 12.8 0.2 0.11 12.8 0.2 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lectin_N PF03954.14 CDI80600.1 - 0.48 10.2 12.8 2.6 7.8 4.0 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF1515 PF07439.11 CDI80600.1 - 3.9 7.5 13.6 2.5 8.2 1.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) SRP_TPR_like PF17004.5 CDI80601.1 - 0.01 15.9 2.1 0.34 10.9 0.1 3.0 2 1 0 2 2 2 0 Putative TPR-like repeat CENP-F_leu_zip PF10473.9 CDI80601.1 - 0.02 14.9 7.1 0.02 14.9 7.1 5.4 2 2 4 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 CDI80601.1 - 2 8.7 45.2 0.63 10.3 4.3 5.2 2 2 5 7 7 7 0 TATA element modulatory factor 1 TATA binding Filament PF00038.21 CDI80601.1 - 7.5 6.0 43.1 0.41 10.2 6.7 4.3 2 2 2 4 4 4 0 Intermediate filament protein WEMBL PF05701.11 CDI80601.1 - 8.6 4.9 52.7 0.48 9.1 19.7 3.1 2 1 1 3 3 3 0 Weak chloroplast movement under blue light GAS PF13851.6 CDI80602.1 - 5.6 6.3 35.8 0.61 9.4 1.1 5.2 4 2 0 4 4 4 0 Growth-arrest specific micro-tubule binding DHC_N1 PF08385.12 CDI80603.1 - 4.2e-114 382.2 1.8 4.2e-114 382.2 1.8 1.7 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 Nup54 PF13874.6 CDI80603.1 - 0.0042 17.2 0.1 0.028 14.5 0.1 2.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 L27 PF02828.16 CDI80603.1 - 3.1 7.6 4.8 2.4 8.0 0.5 2.9 3 0 0 3 3 3 0 L27 domain AAA_6 PF12774.7 CDI80604.1 - 1.6e-113 379.0 1.8 9.4e-62 208.9 0.1 2.3 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI80604.1 - 2.1e-56 191.7 2.3 6.3e-29 101.3 3.2 2.4 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 2 AAA_5 PF07728.14 CDI80604.1 - 2e-06 27.9 0.0 0.012 15.6 0.0 3.7 2 2 1 3 3 3 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDI80604.1 - 0.0033 17.6 0.1 0.57 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CDI80604.1 - 0.0053 17.2 0.0 0.023 15.1 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI80604.1 - 0.039 14.2 0.8 0.73 10.1 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 CDI80604.1 - 0.053 13.0 0.4 2.4 7.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 CDI80604.1 - 0.077 13.5 0.0 1.2 9.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain PI_PP_I PF18363.1 CDI80604.1 - 0.1 12.8 0.8 1.1 9.5 0.1 2.7 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain YmgB PF10798.8 CDI80604.1 - 0.18 11.6 1.1 15 5.5 0.1 2.7 2 0 0 2 2 2 0 Biofilm development protein YmgB/AriR AAA_16 PF13191.6 CDI80604.1 - 7.2 7.0 7.3 6.6 7.1 0.9 3.8 3 2 0 3 3 3 0 AAA ATPase domain AAA_8 PF12780.7 CDI80605.1 - 1.6e-77 260.4 0.0 2.9e-77 259.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 CDI80605.1 - 5.2e-64 215.4 1.0 5.2e-64 215.4 1.0 3.4 3 1 0 3 3 3 1 ATP-binding dynein motor region MT PF12777.7 CDI80605.1 - 9.3e-56 189.3 6.4 1.4e-55 188.8 6.4 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 CDI80605.1 - 1.6e-53 181.9 0.9 4.6e-43 147.6 0.0 3.1 2 1 1 3 3 3 2 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDI80605.1 - 3.1e-21 75.9 0.1 1e-16 61.2 0.1 2.7 1 1 1 2 2 2 2 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI80605.1 - 1.1e-17 64.1 0.5 3.6e-17 62.4 0.1 2.1 2 0 0 2 2 2 1 AAA+ lid domain AAA_7 PF12775.7 CDI80605.1 - 4.9e-11 42.5 0.0 8.5e-10 38.4 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 CDI80605.1 - 0.009 16.0 0.2 1.6 8.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) H-kinase_dim PF02895.14 CDI80605.1 - 0.011 16.1 1.3 6 7.3 0.0 3.6 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain Sec34 PF04136.15 CDI80605.1 - 0.046 13.6 7.7 1.4 8.8 0.3 2.9 2 0 0 2 2 2 0 Sec34-like family VIT1 PF01988.19 CDI80605.1 - 0.51 10.2 6.8 0.23 11.3 2.9 2.2 2 0 0 2 2 2 0 VIT family UPF0242 PF06785.11 CDI80605.1 - 0.61 10.2 18.7 0.65 10.1 4.6 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 CDI80605.1 - 2.6 7.1 18.5 0.97 8.5 6.4 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 CDI80605.1 - 5 6.6 19.6 1.2 8.7 6.4 2.9 1 1 0 2 2 2 0 Exonuclease VII, large subunit kleA_kleC PF17383.2 CDI80605.1 - 8.4 6.8 12.4 16 5.9 0.8 3.8 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A Tctex-1 PF03645.13 CDI80606.1 - 1.2e-18 67.2 0.0 3.5e-18 65.7 0.0 1.9 1 0 0 1 1 1 1 Tctex-1 family WD40 PF00400.32 CDI80606.1 - 0.0014 19.5 6.1 55 4.9 0.0 6.4 7 0 0 7 7 7 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI80606.1 - 0.1 12.9 0.0 12 6.2 0.0 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TMEM191C PF15194.6 CDI80606.1 - 0.15 12.2 2.6 0.74 10.0 2.6 2.3 1 0 0 1 1 1 0 TMEM191C family ADIP PF11559.8 CDI80606.1 - 1.3 9.1 11.4 0.16 12.1 1.8 3.7 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding COMMD1_N PF17221.3 CDI80606.1 - 1.7 9.0 5.1 20 5.5 0.4 3.2 2 0 0 2 2 2 0 COMMD1 N-terminal domain Ephrin_rec_like PF07699.13 CDI80607.1 - 3 7.7 50.5 0.29 10.9 0.8 8.6 7 2 1 8 8 8 0 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 CDI80608.1 - 0.0014 18.3 39.8 0.0084 15.8 7.3 4.9 2 1 2 4 4 4 3 Putative ephrin-receptor like Lustrin_cystein PF14625.6 CDI80608.1 - 0.02 15.2 54.1 0.46 10.9 0.9 7.8 3 2 4 8 8 8 0 Lustrin, cysteine-rich repeated domain NHL PF01436.21 CDI80609.1 - 2.7e-08 33.4 4.2 0.038 14.0 0.2 4.7 5 0 0 5 5 5 3 NHL repeat Ephrin_rec_like PF07699.13 CDI80609.1 - 0.0078 16.0 1.2 0.0078 16.0 1.2 3.3 3 1 0 3 3 3 1 Putative ephrin-receptor like Pkinase PF00069.25 CDI80611.1 - 1.2e-42 146.1 0.0 7.4e-42 143.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80611.1 - 9.8e-19 67.6 0.0 2.5e-13 49.9 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDI80611.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CDI80611.1 - 4.5 7.1 15.1 0.42 10.5 8.6 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family SSP160 PF06933.11 CDI80612.1 - 0.15 10.2 17.9 0.23 9.6 17.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Apt1 PF10351.9 CDI80612.1 - 0.18 10.6 7.8 0.22 10.3 7.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ribosomal_60s PF00428.19 CDI80612.1 - 1.2 9.8 15.6 4.1 8.1 11.0 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF1269 PF06897.12 CDI80612.1 - 2 8.8 5.5 2.1 8.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Macoilin PF09726.9 CDI80612.1 - 4.9 5.6 17.8 12 4.3 17.8 1.6 1 0 0 1 1 1 0 Macoilin family Cupin_4 PF08007.12 CDI80613.1 - 3.8e-09 36.5 0.0 4.9e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein AraC_binding PF02311.19 CDI80613.1 - 0.0045 16.9 0.0 0.0078 16.1 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_8 PF13621.6 CDI80613.1 - 0.0051 16.6 0.0 0.0081 15.9 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 CDI80613.1 - 0.009 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CDI80613.1 - 0.1 12.3 0.0 0.46 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Cupin_1 PF00190.22 CDI80613.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Cupin TetR_C_11 PF16859.5 CDI80614.1 - 0.013 15.8 1.7 0.056 13.8 0.2 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain eIF-5a PF01287.20 CDI80615.1 - 6.3e-26 90.3 0.1 9.5e-26 89.7 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CDI80615.1 - 0.0016 18.4 0.0 0.003 17.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain MAP PF03642.13 CDI80615.1 - 0.14 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 MAP domain eIF_4EBP PF05456.11 CDI80616.1 - 0.1 12.6 4.4 0.11 12.5 4.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Presenilin PF01080.17 CDI80616.1 - 0.19 10.5 2.0 0.19 10.4 2.0 1.0 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI80616.1 - 0.71 9.4 15.3 0.73 9.4 15.3 1.0 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 CDI80616.1 - 2.8 6.7 13.7 2.6 6.8 13.7 1.1 1 0 0 1 1 1 0 Androgen receptor DUF2722 PF10846.8 CDI80616.1 - 6.1 5.7 15.4 6.3 5.6 15.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Med19 PF10278.9 CDI80617.1 - 0.0015 18.5 3.2 0.0015 18.5 3.2 3.7 4 0 0 4 4 4 1 Mediator of RNA pol II transcription subunit 19 CNDH2_C PF16858.5 CDI80617.1 - 0.0062 16.5 8.2 0.0062 16.5 8.2 4.5 5 1 0 5 5 5 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term NAM-associated PF14303.6 CDI80617.1 - 0.026 15.2 0.1 0.026 15.2 0.1 7.1 7 2 1 8 8 8 0 No apical meristem-associated C-terminal domain SLC12 PF03522.15 CDI80617.1 - 0.084 11.9 34.2 1.7 7.6 10.6 3.6 3 0 0 3 3 3 0 Solute carrier family 12 Sin_N PF04801.13 CDI80617.1 - 0.14 11.4 62.1 0.0074 15.5 17.9 4.6 4 0 0 4 4 4 0 Sin-like protein conserved region AAA_11 PF13086.6 CDI80617.1 - 0.23 11.2 30.9 0.28 11.0 7.1 3.6 3 0 0 3 3 3 0 AAA domain CD20 PF04103.15 CDI80617.1 - 0.32 11.1 0.0 0.32 11.1 0.0 5.7 5 2 1 6 6 6 0 CD20-like family Utp14 PF04615.13 CDI80617.1 - 0.66 8.5 39.6 0.1 11.2 6.2 4.3 3 1 1 4 4 4 0 Utp14 protein FTR PF01913.18 CDI80617.1 - 0.79 9.7 6.4 0.32 10.9 1.4 2.5 2 0 0 2 2 2 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase Cation_ATPase_C PF00689.21 CDI80618.1 - 1.3e-09 38.0 3.4 6.4e-07 29.3 3.4 2.1 1 1 0 1 1 1 1 Cation transporting ATPase, C-terminus CDC27 PF09507.10 CDI80619.1 - 0.11 11.8 33.6 0.2 11.0 33.6 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Utp14 PF04615.13 CDI80619.1 - 0.12 10.9 37.8 0.16 10.5 37.8 1.1 1 0 0 1 1 1 0 Utp14 protein DUF2457 PF10446.9 CDI80619.1 - 0.3 10.2 39.2 0.54 9.4 39.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PI3K_1B_p101 PF10486.9 CDI80619.1 - 1.3 6.7 19.2 1.8 6.2 19.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Ndc1_Nup PF09531.10 CDI80619.1 - 3.6 6.2 11.1 5.6 5.5 11.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SMYLE_N PF18615.1 CDI80619.1 - 4.9 6.6 15.9 8.3 5.9 15.9 1.4 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain LAP1C PF05609.12 CDI80619.1 - 9.1 5.2 31.7 13 4.7 31.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2828 PF11443.8 CDI80620.1 - 1.7 6.6 25.9 0.12 10.4 11.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF1467 PF07330.12 CDI80620.1 - 8.5 6.4 6.4 1.7 8.6 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) WD40 PF00400.32 CDI80621.1 - 5.4e-35 118.8 20.2 8.9e-09 35.9 2.4 8.9 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI80621.1 - 1.5e-08 34.8 0.7 0.034 14.4 0.0 4.3 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDI80621.1 - 1.6e-06 27.1 1.9 0.22 10.1 0.1 4.1 3 1 2 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CDI80621.1 - 0.00015 20.7 0.2 0.086 11.6 0.0 3.4 2 2 2 4 4 4 1 Nup133 N terminal like Ge1_WD40 PF16529.5 CDI80621.1 - 0.013 14.4 2.5 0.15 10.9 0.3 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lipase_3 PF01764.25 CDI80622.1 - 2.6e-18 66.3 0.0 5.1e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CDI80622.1 - 0.00057 20.5 3.1 0.0028 18.3 0.1 3.1 2 1 0 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDI80622.1 - 0.0052 16.1 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 CDI80622.1 - 0.046 13.2 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PGAP1 PF07819.13 CDI80622.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 CDI80622.1 - 0.16 12.0 0.1 0.32 11.1 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain Pkinase PF00069.25 CDI80623.1 - 9.7e-69 231.7 1.5 1.5e-68 231.0 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80623.1 - 1.8e-33 115.9 0.1 4.4e-33 114.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI80623.1 - 1 8.0 4.9 1.3 7.7 0.0 2.9 2 0 0 2 2 2 0 Fungal protein kinase TFIIA PF03153.13 CDI80624.1 - 0.0052 16.8 37.2 0.0063 16.6 37.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CCDC106 PF15794.5 CDI80624.1 - 1.5 8.5 20.9 0.41 10.3 2.7 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF1943 PF09172.11 CDI80624.1 - 6.1 6.0 8.5 5.3 6.2 4.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) D123 PF07065.14 CDI80624.1 - 7.2 5.7 13.8 1.2 8.2 0.4 2.1 2 0 0 2 2 2 0 D123 AlkA_N PF06029.11 CDI80625.1 - 0.02 15.1 2.5 0.076 13.3 2.5 2.0 1 0 0 1 1 1 0 AlkA N-terminal domain SIT PF15330.6 CDI80626.1 - 0.039 14.4 0.0 0.063 13.7 0.0 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT CECR6_TMEM121 PF14997.6 CDI80627.1 - 6.5e-08 32.6 1.5 1e-07 32.0 1.5 1.3 1 0 0 1 1 1 1 CECR6/TMEM121 family Tmem26 PF09772.9 CDI80627.1 - 0.017 14.5 0.2 0.017 14.5 0.2 2.0 2 0 0 2 2 2 0 Transmembrane protein 26 Lin-8 PF03353.15 CDI80627.1 - 0.062 12.9 5.7 0.085 12.4 5.7 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SART-1 PF03343.13 CDI80627.1 - 0.16 10.5 10.2 0.23 10.0 10.2 1.1 1 0 0 1 1 1 0 SART-1 family FAM176 PF14851.6 CDI80627.1 - 0.18 11.5 2.4 1.2 8.8 1.4 2.6 2 0 0 2 2 2 0 FAM176 family Sin_N PF04801.13 CDI80627.1 - 0.2 10.8 10.1 0.28 10.3 10.1 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region TFIIA PF03153.13 CDI80627.1 - 0.32 10.9 21.1 0.47 10.4 21.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI80627.1 - 0.56 9.8 20.6 1 8.9 20.6 1.4 1 0 0 1 1 1 0 Spt20 family YABBY PF04690.13 CDI80627.1 - 1.1 9.8 5.6 1.9 9.1 5.6 1.3 1 0 0 1 1 1 0 YABBY protein Presenilin PF01080.17 CDI80627.1 - 2 7.1 8.1 3.6 6.2 8.1 1.4 1 0 0 1 1 1 0 Presenilin LCCL PF03815.19 CDI80628.1 - 3.6e-07 30.2 0.4 1e-06 28.8 0.4 1.7 1 0 0 1 1 1 1 LCCL domain LEP503 PF15221.6 CDI80631.1 - 0.0031 17.8 0.0 0.0056 17.0 0.0 1.4 1 0 0 1 1 1 1 Lens epithelial cell protein LEP503 Peptidase_M41 PF01434.18 CDI80634.1 - 1.6e-51 174.9 0.0 3.2e-51 173.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CDI80634.1 - 4.7e-29 101.5 0.0 1.1e-28 100.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI80634.1 - 9.5e-14 50.9 0.1 1.5e-11 43.9 0.1 2.7 2 0 0 2 2 2 1 AAA+ lid domain Macoilin PF09726.9 CDI80634.1 - 2.6 6.5 36.3 0.26 9.8 13.9 2.1 2 0 0 2 2 2 0 Macoilin family Apt1 PF10351.9 CDI80634.1 - 9.1 5.0 36.7 0.26 10.1 14.0 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Otopetrin PF03189.13 CDI80635.1 - 0.00012 21.0 0.0 0.00048 19.1 0.0 1.9 1 1 0 1 1 1 1 Otopetrin Ndc1_Nup PF09531.10 CDI80635.1 - 0.36 9.5 33.7 0.018 13.7 21.4 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Rcd1 PF04078.13 CDI80636.1 - 8.5e-33 113.7 0.1 8.5e-33 113.7 0.1 1.8 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like DUF2722 PF10846.8 CDI80636.1 - 0.0085 15.1 3.0 0.0085 15.1 3.0 4.0 2 1 2 4 4 4 1 Protein of unknown function (DUF2722) DUF3837 PF12939.7 CDI80636.1 - 0.16 12.4 0.1 0.16 12.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3837) DUF3474 PF11960.8 CDI80636.1 - 0.6 10.3 6.0 0.24 11.6 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) SMN PF06003.12 CDI80636.1 - 2.5 7.3 13.8 3.1 7.0 12.3 1.7 1 1 1 2 2 2 0 Survival motor neuron protein (SMN) Cytochrom_C PF00034.21 CDI80637.1 - 3.5e-07 31.3 1.2 5.1e-06 27.5 0.0 2.5 2 1 0 2 2 2 1 Cytochrome c Cytochrom_C550 PF14495.6 CDI80637.1 - 0.0051 16.5 0.1 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 Cytochrome c-550 domain Cytochrome_CBB3 PF13442.6 CDI80637.1 - 0.0077 16.5 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Spt20 PF12090.8 CDI80637.1 - 0.17 11.5 11.0 0.22 11.1 11.0 1.1 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 CDI80638.1 - 0.034 14.2 0.2 0.034 14.2 0.2 7.9 6 3 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI80638.1 - 3 7.4 82.6 0.37 10.4 0.2 6.3 5 1 1 6 6 6 0 Spt20 family Aquarius_N PF16399.5 CDI80639.1 - 3.1e-151 505.1 0.0 8.3e-85 285.4 0.0 5.5 5 1 0 5 5 4 3 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 CDI80639.1 - 4.3e-23 82.4 62.5 6.8e-19 68.7 37.5 5.3 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.6 CDI80639.1 - 6.2e-07 29.9 1.5 0.00027 21.3 0.0 3.5 3 1 0 3 3 3 1 AAA domain Caldesmon PF02029.15 CDI80639.1 - 0.00043 19.2 23.3 0.00043 19.2 23.3 3.3 3 0 0 3 3 3 1 Caldesmon Spt20 PF12090.8 CDI80639.1 - 0.00051 19.7 29.2 0.00051 19.7 29.2 8.3 7 2 1 8 8 6 2 Spt20 family AAA_22 PF13401.6 CDI80639.1 - 0.0095 16.2 0.0 0.0095 16.2 0.0 3.8 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 CDI80639.1 - 0.01 16.2 0.0 0.41 11.1 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CDI80639.1 - 0.01 15.2 0.0 0.41 10.0 0.0 2.5 2 0 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 CDI80639.1 - 0.016 14.6 0.3 0.092 12.1 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CDI80639.1 - 0.018 14.6 2.8 0.047 13.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain DUF5591 PF17884.1 CDI80639.1 - 0.02 14.8 0.8 0.065 13.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5591) AAA_5 PF07728.14 CDI80639.1 - 0.022 14.8 0.0 0.079 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI80639.1 - 0.037 14.6 0.5 0.39 11.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 CDI80639.1 - 0.039 13.9 0.0 0.039 13.9 0.0 3.6 3 1 0 3 3 2 0 Type III restriction enzyme, res subunit Utp14 PF04615.13 CDI80639.1 - 0.56 8.7 57.4 1.2 7.6 28.1 2.4 2 1 0 2 2 2 0 Utp14 protein AAA_28 PF13521.6 CDI80639.1 - 0.77 10.0 0.0 0.77 10.0 0.0 6.1 8 1 0 8 8 4 0 AAA domain SR-25 PF10500.9 CDI80641.1 - 0.0006 19.5 8.0 0.0006 19.5 8.0 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF4207 PF13904.6 CDI80641.1 - 0.011 15.5 5.9 0.011 15.5 5.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) TFIIA PF03153.13 CDI80641.1 - 0.016 15.2 16.2 0.022 14.7 16.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SH2_2 PF14633.6 CDI80641.1 - 0.031 13.7 0.6 0.05 13.0 0.6 1.3 1 0 0 1 1 1 0 SH2 domain MAS20 PF02064.15 CDI80641.1 - 0.036 14.1 3.7 0.064 13.4 2.7 1.8 1 1 0 1 1 1 0 MAS20 protein import receptor BORCS6 PF10157.9 CDI80641.1 - 0.056 13.7 0.5 0.056 13.7 0.5 2.7 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 6 Roughex PF06020.11 CDI80641.1 - 0.078 12.1 0.9 0.12 11.4 0.9 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Hamartin PF04388.12 CDI80642.1 - 0.81 8.3 20.1 0.92 8.1 20.1 1.0 1 0 0 1 1 1 0 Hamartin protein DUF3984 PF13136.6 CDI80642.1 - 1.2 8.5 18.0 1.3 8.4 18.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) RPN2_C PF18004.1 CDI80642.1 - 1.6 8.6 21.8 1.8 8.4 21.8 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Ureide_permease PF07168.11 CDI80642.1 - 3.7 6.2 11.0 4 6.1 11.0 1.1 1 0 0 1 1 1 0 Ureide permease DUF3450 PF11932.8 CDI80642.1 - 4.4 6.5 46.0 5.1 6.3 46.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SID-1_RNA_chan PF13965.6 CDI80642.1 - 5 5.4 10.3 5.1 5.4 10.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AMP-binding PF00501.28 CDI80642.1 - 5.9 5.4 8.5 6 5.3 8.5 1.0 1 0 0 1 1 1 0 AMP-binding enzyme BAF1_ABF1 PF04684.13 CDI80642.1 - 6.2 5.8 23.5 7 5.6 23.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Acyl-CoA_dh_N PF02771.16 CDI80644.1 - 4e-23 82.2 0.1 7.1e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CDI80644.1 - 2.2e-13 50.2 0.1 3.7e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 CDI80644.1 - 0.0034 17.9 1.7 0.016 15.8 0.0 2.3 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Inj_translocase PF16928.5 CDI80644.1 - 0.085 12.3 5.1 0.12 11.8 5.1 1.2 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome Med3 PF11593.8 CDI80644.1 - 1.3 8.1 7.3 1.8 7.7 7.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ribosomal_L1 PF00687.21 CDI80645.1 - 2.4e-14 53.5 0.1 4e-14 52.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family CDC45 PF02724.14 CDI80646.1 - 0.0011 17.4 16.9 0.0011 17.4 16.9 2.4 2 1 0 2 2 2 1 CDC45-like protein DUF755 PF05501.11 CDI80647.1 - 0.15 12.3 12.9 0.28 11.5 12.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF885 PF05960.11 CDI80647.1 - 2.4 7.7 23.5 3.4 7.2 23.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) SR-25 PF10500.9 CDI80647.1 - 3.7 7.1 16.8 7 6.2 16.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDI80647.1 - 8.3 6.9 9.1 9.9 6.7 9.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein XRN_N PF03159.18 CDI80648.1 - 0.00025 20.6 7.0 0.0003 20.3 7.0 1.1 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus TFIIA PF03153.13 CDI80648.1 - 0.0072 16.4 39.9 0.0088 16.1 39.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 CDI80648.1 - 0.0075 15.9 24.3 0.0094 15.6 24.3 1.1 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist SpoIIP PF07454.11 CDI80648.1 - 0.015 14.8 10.1 0.016 14.7 10.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4770 PF15994.5 CDI80648.1 - 0.017 15.4 10.2 0.021 15.0 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) eIF-3_zeta PF05091.12 CDI80648.1 - 0.03 13.3 14.0 0.032 13.2 14.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Macoilin PF09726.9 CDI80648.1 - 0.043 12.4 23.2 0.049 12.2 23.2 1.0 1 0 0 1 1 1 0 Macoilin family Draxin PF15550.6 CDI80648.1 - 0.048 13.5 13.1 0.059 13.2 13.1 1.0 1 0 0 1 1 1 0 Draxin RR_TM4-6 PF06459.12 CDI80648.1 - 0.053 13.4 10.3 0.058 13.2 10.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 CDI80648.1 - 0.057 12.8 15.9 0.068 12.6 15.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tim54 PF11711.8 CDI80648.1 - 0.077 11.8 9.2 0.083 11.7 9.2 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NARP1 PF12569.8 CDI80648.1 - 0.2 10.5 10.3 0.24 10.3 10.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 VIR_N PF15912.5 CDI80648.1 - 0.29 10.7 7.8 0.4 10.2 7.8 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal FmiP_Thoc5 PF09766.9 CDI80648.1 - 0.29 10.4 18.0 0.4 9.9 18.0 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Connexin PF00029.19 CDI80648.1 - 0.38 10.5 8.4 0.44 10.3 8.4 1.2 1 0 0 1 1 1 0 Connexin PAT1 PF09770.9 CDI80648.1 - 0.5 8.6 29.7 0.54 8.5 29.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S49_N PF08496.10 CDI80648.1 - 0.99 9.5 9.2 1.4 9.0 9.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4407 PF14362.6 CDI80648.1 - 1.1 8.6 16.8 1.3 8.4 16.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM76 PF16046.5 CDI80648.1 - 1.1 8.6 20.4 1.3 8.3 20.4 1.1 1 0 0 1 1 1 0 FAM76 protein Plasmodium_Vir PF05795.11 CDI80648.1 - 1.1 8.5 15.6 1.4 8.3 15.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein NST1 PF13945.6 CDI80648.1 - 1.2 9.2 27.8 1.7 8.7 27.8 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Peptidase_S64 PF08192.11 CDI80648.1 - 1.7 7.1 25.4 2 6.8 25.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 HemX PF04375.14 CDI80648.1 - 1.9 7.7 25.9 2.5 7.3 25.9 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase GREB1 PF15782.5 CDI80648.1 - 2 5.4 27.9 2.2 5.3 27.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Paf1 PF03985.13 CDI80648.1 - 2.3 7.1 15.1 3.3 6.6 15.1 1.2 1 0 0 1 1 1 0 Paf1 SLC12 PF03522.15 CDI80648.1 - 2.5 7.0 19.4 3 6.8 19.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF3408 PF11888.8 CDI80648.1 - 2.5 8.2 14.2 4.5 7.4 14.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CDC45 PF02724.14 CDI80648.1 - 3.3 5.9 13.6 3.7 5.7 13.6 1.0 1 0 0 1 1 1 0 CDC45-like protein G0-G1_switch_2 PF15103.6 CDI80648.1 - 3.6 8.1 8.8 5.9 7.4 8.8 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 Folate_carrier PF01770.18 CDI80648.1 - 4.4 5.9 6.5 6.4 5.4 6.5 1.2 1 0 0 1 1 1 0 Reduced folate carrier Apt1 PF10351.9 CDI80648.1 - 4.5 6.0 23.3 5.4 5.8 23.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4638 PF15472.6 CDI80648.1 - 4.8 6.8 14.3 5.9 6.6 14.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) SPX PF03105.19 CDI80648.1 - 5.5 6.8 27.3 6.3 6.6 27.3 1.1 1 0 0 1 1 1 0 SPX domain CBP_BcsG PF11658.8 CDI80648.1 - 5.5 5.3 11.3 7.1 4.9 11.3 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG ALMT PF11744.8 CDI80648.1 - 7.3 5.3 15.1 8.6 5.1 15.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4175 PF13779.6 CDI80648.1 - 9.2 4.0 34.4 12 3.7 34.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Spc7_N PF15402.6 CDI80648.1 - 9.3 4.4 30.5 10 4.2 30.5 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 SUIM_assoc PF16619.5 CDI80649.1 - 0.0057 16.7 2.2 0.0057 16.7 2.2 7.1 6 1 0 6 6 6 1 Unstructured region C-term to UIM in Ataxin3 Pantoate_ligase PF02569.15 CDI80650.1 - 9.1e-32 110.3 1.7 9.6e-32 110.2 0.0 1.9 3 0 0 3 3 3 1 Pantoate-beta-alanine ligase SUIM_assoc PF16619.5 CDI80650.1 - 5e-05 23.3 27.1 0.029 14.4 8.5 4.2 4 0 0 4 4 4 3 Unstructured region C-term to UIM in Ataxin3 Acetyltransf_10 PF13673.7 CDI80650.1 - 0.00019 21.4 0.5 0.00038 20.4 0.5 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDI80650.1 - 0.077 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDI80650.1 - 0.18 12.3 0.2 0.46 11.0 0.2 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CTP_transf_like PF01467.26 CDI80650.1 - 0.18 12.0 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 Cytidylyltransferase-like DDOST_48kD PF03345.14 CDI80652.1 - 7.5e-10 38.2 0.1 0.0012 17.8 0.0 3.2 2 1 1 3 3 3 3 Oligosaccharyltransferase 48 kDa subunit beta YebO PF13974.6 CDI80652.1 - 9.4 6.4 6.6 7.5 6.7 4.4 1.9 2 0 0 2 2 2 0 YebO-like protein Peptidase_C14 PF00656.22 CDI80655.1 - 1.8e-24 87.0 0.0 8.4e-23 81.6 0.0 2.5 2 0 0 2 2 2 2 Caspase domain DUF383 PF04063.14 CDI80656.1 - 0.02 14.5 0.0 0.02 14.5 0.0 3.4 1 1 1 3 3 3 0 Domain of unknown function (DUF383) CAF1 PF04857.20 CDI80656.1 - 0.15 11.2 10.6 0.35 10.0 0.2 2.9 2 1 1 3 3 3 0 CAF1 family ribonuclease DUF2828 PF11443.8 CDI80656.1 - 0.17 9.9 9.4 0.33 9.0 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) OATP PF03137.20 CDI80656.1 - 0.52 8.5 2.3 2 6.6 0.3 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PepSY_TM PF03929.16 CDI80656.1 - 2.5 7.7 5.0 12 5.4 1.6 2.3 2 0 0 2 2 2 0 PepSY-associated TM region V_ATPase_I PF01496.19 CDI80656.1 - 4.2 5.2 11.8 0.88 7.4 3.2 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 CDI80656.1 - 8.2 5.4 7.4 4.9 6.1 1.4 2.3 2 0 0 2 2 2 0 CLN3 protein Ldh_1_N PF00056.23 CDI80658.1 - 3.1e-38 131.0 0.1 5.6e-38 130.2 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDI80658.1 - 7.4e-30 104.1 0.1 1.5e-29 103.1 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 CDI80658.1 - 7.1e-06 25.7 0.2 7.2e-05 22.4 0.1 2.2 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase NAD_binding_8 PF13450.6 CDI80658.1 - 0.015 15.5 0.0 0.041 14.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HTH_18 PF12833.7 CDI80658.1 - 0.051 13.8 0.0 0.084 13.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DSHCT PF08148.12 CDI80658.1 - 0.089 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 DSHCT (NUC185) domain NMT PF01233.19 CDI80662.1 - 4.2e-66 221.7 0.1 5.6e-66 221.3 0.1 1.1 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 CDI80662.1 - 0.00037 20.7 0.0 0.00058 20.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CDI80662.1 - 0.00042 20.4 0.0 0.0006 19.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDI80662.1 - 0.12 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDI80662.1 - 0.14 12.6 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Trp_oprn_chp PF09534.10 CDI80663.1 - 0.22 11.3 17.2 0.62 9.8 0.6 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RskA PF10099.9 CDI80663.1 - 0.29 11.4 41.2 1.2 9.4 21.8 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA U1snRNP70_N PF12220.8 CDI80663.1 - 1.6 9.4 13.5 0.61 10.8 7.6 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DivIC PF04977.15 CDI80663.1 - 7 6.5 31.7 0.067 13.0 15.1 2.2 2 0 0 2 2 2 0 Septum formation initiator Connexin PF00029.19 CDI80663.1 - 8.2 6.1 9.6 1.2 8.9 5.3 1.7 2 0 0 2 2 2 0 Connexin Pex14_N PF04695.13 CDI80663.1 - 8.6 7.0 35.6 3.8 8.1 16.2 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SUIM_assoc PF16619.5 CDI80664.1 - 0.0026 17.8 16.6 0.018 15.1 7.3 2.6 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 ANAPC_CDC26 PF10471.9 CDI80664.1 - 0.0046 17.8 9.4 0.016 16.0 3.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 CDI80664.1 - 0.065 12.8 17.4 0.098 12.3 8.1 2.2 2 0 0 2 2 2 0 Spt20 family Androgen_recep PF02166.16 CDI80664.1 - 0.14 11.0 12.4 1.8 7.3 7.9 2.2 2 0 0 2 2 2 0 Androgen receptor DUF3169 PF11368.8 CDI80664.1 - 3.2 7.2 14.7 2.5 7.5 9.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) DnaJ PF00226.31 CDI80665.1 - 3.9e-29 100.6 0.7 7.1e-29 99.7 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain GHMP_kinases_N PF00288.26 CDI80665.1 - 0.046 14.0 1.0 0.077 13.2 1.0 1.4 1 0 0 1 1 1 0 GHMP kinases N terminal domain Glyco_hydro_9 PF00759.19 CDI80665.1 - 0.1 12.0 0.9 0.095 12.1 0.9 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 PPI_Ypi1 PF07491.11 CDI80667.1 - 3.4e-21 74.8 0.4 3.4e-21 74.8 0.4 1.6 2 0 0 2 2 2 1 Protein phosphatase inhibitor IMUP PF15761.5 CDI80667.1 - 0.0076 16.9 8.8 0.0076 16.9 8.8 2.2 2 0 0 2 2 2 1 Immortalisation up-regulated protein Dehydrin PF00257.19 CDI80667.1 - 0.78 10.3 13.2 1.3 9.5 13.2 1.4 1 1 0 1 1 1 0 Dehydrin Kinase-like PF14531.6 CDI80668.1 - 5.3e-08 32.5 0.0 1e-07 31.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI80668.1 - 3.3e-06 26.6 0.0 1.4e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80668.1 - 3.7e-06 26.4 0.0 5.6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3597 PF12200.8 CDI80668.1 - 0.11 13.0 0.3 0.73 10.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Pkinase PF00069.25 CDI80669.1 - 2.4e-11 43.5 0.0 3.9e-11 42.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI80669.1 - 3e-08 33.3 0.0 4.5e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI80669.1 - 1.5e-06 27.7 0.0 2.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HlyIII PF03006.20 CDI80670.1 - 2.1e-20 73.4 14.1 2.8e-20 73.0 14.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3591 PF12157.8 CDI80672.1 - 3.3e-26 91.9 0.0 2.9e-12 46.0 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF3591) Bromodomain PF00439.25 CDI80672.1 - 1.6e-14 53.7 0.0 2.9e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain zf-CCHC_6 PF15288.6 CDI80672.1 - 0.0018 18.1 1.2 0.0049 16.7 1.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Hormone_4 PF00220.17 CDI80672.1 - 2.2 8.5 4.7 1 9.5 0.6 2.6 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain PBP1_TM PF14812.6 CDI80672.1 - 4.8 7.6 12.6 4.6 7.7 3.8 3.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Patched PF02460.18 CDI80674.1 - 2.3e-97 327.0 1.5 6e-62 209.9 0.4 2.8 3 0 0 3 3 3 2 Patched family Sterol-sensing PF12349.8 CDI80674.1 - 2.7e-26 92.2 3.9 2.7e-26 92.2 3.9 2.2 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 CDI80674.1 - 2.5e-07 28.8 10.0 5.1e-07 27.8 10.0 1.4 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family DUF4525 PF15027.6 CDI80674.1 - 0.046 13.5 0.7 0.18 11.5 0.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Macoilin PF09726.9 CDI80674.1 - 4.7 5.7 26.2 1.5 7.3 23.0 1.7 2 0 0 2 2 2 0 Macoilin family Ank_2 PF12796.7 CDI80675.1 - 3.7e-30 104.3 0.2 0.00011 22.7 0.1 6.4 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 CDI80675.1 - 2.5e-18 65.6 14.1 7.4e-05 23.0 0.0 9.2 10 0 0 10 10 10 5 Ankyrin repeat Ank_3 PF13606.6 CDI80675.1 - 4.2e-17 60.5 11.6 0.021 15.3 0.0 9.9 10 0 0 10 10 10 4 Ankyrin repeat Ank_5 PF13857.6 CDI80675.1 - 4.4e-17 61.9 5.7 0.0054 17.0 0.0 8.0 7 3 2 9 9 9 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI80675.1 - 3.9e-16 59.2 6.1 0.041 14.5 0.1 7.7 6 2 1 7 7 7 5 Ankyrin repeats (many copies) cEGF PF12662.7 CDI80676.1 - 0.031 14.2 0.3 0.077 12.9 0.3 1.6 1 0 0 1 1 1 0 Complement Clr-like EGF-like TIL PF01826.17 CDI80676.1 - 0.06 13.6 1.7 0.1 12.8 1.7 1.3 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain EGF PF00008.27 CDI80676.1 - 0.097 13.0 5.3 0.14 12.5 3.2 2.1 2 0 0 2 2 2 0 EGF-like domain DUF2207 PF09972.9 CDI80676.1 - 0.14 10.9 0.0 0.22 10.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) hEGF PF12661.7 CDI80676.1 - 5.9 7.7 8.7 3.8 8.3 4.4 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF SUIM_assoc PF16619.5 CDI80677.1 - 0.00072 19.6 0.0 0.00072 19.6 0.0 16.9 9 5 1 10 10 10 1 Unstructured region C-term to UIM in Ataxin3 BUD22 PF09073.10 CDI80677.1 - 0.001 18.5 6.4 0.001 18.5 6.4 5.9 4 3 1 5 5 5 2 BUD22 DUF4746 PF15928.5 CDI80677.1 - 0.0057 16.1 10.6 0.0057 16.1 10.6 4.8 5 0 0 5 5 5 1 Domain of unknown function (DUF4746) DUF3446 PF11928.8 CDI80677.1 - 0.018 15.3 0.7 0.018 15.3 0.7 13.9 9 3 1 10 10 10 0 Early growth response N-terminal domain DUF2972 PF11186.8 CDI80679.1 - 0.11 12.4 0.7 0.17 11.8 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) SAPS PF04499.15 CDI80679.1 - 4.1 6.1 6.9 6.4 5.4 0.5 2.3 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Rsd_AlgQ PF04353.13 CDI80680.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ SR-25 PF10500.9 CDI80680.1 - 0.22 11.1 12.4 0.53 9.9 12.4 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Na_H_Exchanger PF00999.21 CDI80685.1 - 2e-29 102.6 21.6 2e-29 102.6 21.6 1.9 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family ECF_trnsprt PF12822.7 CDI80685.1 - 0.0096 16.0 9.9 0.0096 16.0 9.9 3.0 3 0 0 3 3 3 2 ECF transporter, substrate-specific component XAP5 PF04921.14 CDI80686.1 - 1.2e-67 228.3 2.3 1.2e-67 228.3 2.3 2.6 1 1 2 3 3 3 2 XAP5, circadian clock regulator Hamartin PF04388.12 CDI80686.1 - 0.089 11.4 11.8 0.14 10.8 11.8 1.3 1 0 0 1 1 1 0 Hamartin protein PAP1 PF08601.10 CDI80686.1 - 0.13 12.0 17.0 0.17 11.6 17.0 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 SAP130_C PF16014.5 CDI80686.1 - 0.22 10.6 10.2 0.016 14.3 5.6 1.4 2 0 0 2 2 2 0 Histone deacetylase complex subunit SAP130 C-terminus Lin-8 PF03353.15 CDI80686.1 - 1.1 8.7 13.9 0.11 12.1 9.4 1.6 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI80686.1 - 5.4 4.0 15.8 6.5 3.7 15.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AP2 PF00847.20 CDI80687.1 - 1e-08 35.3 7.1 1e-08 35.3 7.1 3.0 2 0 0 2 2 2 1 AP2 domain RskA PF10099.9 CDI80687.1 - 0.00062 20.1 2.7 0.00062 20.1 2.7 7.2 1 1 4 5 5 5 1 Anti-sigma-K factor rskA SPX PF03105.19 CDI80687.1 - 0.066 13.1 13.0 0.27 11.1 10.2 2.3 2 0 0 2 2 2 0 SPX domain Macoilin PF09726.9 CDI80687.1 - 7.1 5.1 20.3 7 5.1 1.8 2.7 2 1 0 2 2 2 0 Macoilin family MAP70 PF07058.11 CDI80687.1 - 9.6 4.8 6.9 19 3.9 6.9 1.4 1 0 0 1 1 1 0 Microtubule-associated protein 70 TFIIA PF03153.13 CDI80688.1 - 0.11 12.5 16.4 0.13 12.2 16.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cyto_heme_lyase PF01265.17 CDI80688.1 - 0.55 9.8 8.5 0.63 9.6 8.5 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase bZIP_C PF12498.8 CDI80688.1 - 0.58 11.2 7.5 0.68 10.9 7.5 1.1 1 0 0 1 1 1 0 Basic leucine-zipper C terminal DUF4175 PF13779.6 CDI80688.1 - 0.91 7.4 14.2 0.87 7.4 14.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) eIF-3_zeta PF05091.12 CDI80688.1 - 1.6 7.6 7.6 1.6 7.7 7.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4655 PF15548.6 CDI80688.1 - 2 7.3 15.8 2.2 7.1 15.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4655) Presenilin PF01080.17 CDI80688.1 - 3.4 6.3 8.9 3.8 6.2 8.9 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 CDI80688.1 - 4.8 7.1 13.1 5.3 6.9 13.1 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM199X PF15814.5 CDI80688.1 - 5 6.1 14.1 5.7 5.9 14.1 1.1 1 0 0 1 1 1 0 Protein family FAM199X DUF3043 PF11241.8 CDI80688.1 - 5.3 7.1 7.0 6.7 6.7 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Neur_chan_memb PF02932.16 CDI80688.1 - 7.2 6.6 6.6 8.6 6.3 6.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SUIM_assoc PF16619.5 CDI80689.1 - 0.042 13.9 0.9 0.042 13.9 0.9 8.4 4 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 TPR_8 PF13181.6 CDI80690.1 - 0.0011 19.0 0.7 0.025 14.8 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Caldesmon PF02029.15 CDI80690.1 - 0.0012 17.7 5.5 0.0012 17.7 5.5 3.4 3 0 0 3 3 3 2 Caldesmon TPR_1 PF00515.28 CDI80690.1 - 0.0019 17.9 3.8 0.18 11.7 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat SR-25 PF10500.9 CDI80690.1 - 0.0033 17.1 16.5 0.0033 17.1 16.5 5.7 5 1 1 6 6 6 3 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 CDI80690.1 - 0.0048 17.0 3.4 0.0048 17.0 3.4 9.4 5 3 5 10 10 10 2 Cyclin-dependent kinase 2-associated protein TPR_2 PF07719.17 CDI80690.1 - 0.023 14.8 1.0 0.023 14.8 1.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat tRNA-synt_2b PF00587.25 CDI80693.1 - 1.6e-29 103.2 0.0 5.3e-28 98.2 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDI80693.1 - 1.3e-16 60.5 0.1 3.2e-16 59.3 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 CDI80693.1 - 3.1e-12 46.4 0.0 9e-12 44.9 0.0 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 CDI80693.1 - 2.6e-09 37.0 0.0 0.00013 21.9 0.0 2.4 2 0 0 2 2 2 2 TGS domain Apt1 PF10351.9 CDI80693.1 - 0.09 11.6 23.2 1.3 7.8 17.6 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain SOG2 PF10428.9 CDI80693.1 - 0.42 9.8 27.5 0.31 10.2 19.4 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein SPX PF03105.19 CDI80693.1 - 0.81 9.5 24.5 4.7 7.0 0.2 2.3 2 0 0 2 2 2 0 SPX domain NPR3 PF03666.13 CDI80693.1 - 1.9 7.1 12.4 5.2 5.7 9.3 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 AAA_23 PF13476.6 CDI80694.1 - 0.14 12.7 12.8 1.6 9.2 8.1 2.3 2 0 0 2 2 2 0 AAA domain NPR3 PF03666.13 CDI80694.1 - 1.6 7.4 14.6 0.16 10.7 7.0 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 CDI80694.1 - 2.5 7.0 16.7 1.3 7.9 9.2 2.4 2 0 0 2 2 2 0 Solute carrier family 12 CDC45 PF02724.14 CDI80694.1 - 2.6 6.3 9.3 0.97 7.6 4.3 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF3402 PF11882.8 CDI80694.1 - 3 6.8 14.9 4.1 6.4 5.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) DUF4551 PF15087.6 CDI80694.1 - 3.3 6.4 20.9 0.74 8.6 4.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) RskA PF10099.9 CDI80695.1 - 0.00021 21.6 7.4 0.00028 21.2 7.4 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Zn_peptidase PF04228.13 CDI80695.1 - 0.00039 20.0 0.5 0.00039 20.0 0.5 1.7 2 0 0 2 2 2 1 Putative neutral zinc metallopeptidase Nop53 PF07767.11 CDI80695.1 - 0.011 15.1 19.8 0.015 14.7 19.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TFIIF_alpha PF05793.12 CDI80695.1 - 0.38 9.3 16.5 0.49 8.9 16.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RRN3 PF05327.11 CDI80695.1 - 0.42 9.1 7.3 0.5 8.9 7.3 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BAF1_ABF1 PF04684.13 CDI80695.1 - 0.8 8.7 16.6 0.93 8.5 16.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SAPS PF04499.15 CDI80695.1 - 0.81 8.4 11.4 0.97 8.1 11.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MDM31_MDM32 PF08118.11 CDI80695.1 - 1.2 7.7 8.8 1.9 7.0 8.7 1.5 1 1 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins SLC12 PF03522.15 CDI80695.1 - 1.3 7.9 9.6 1.7 7.6 9.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Med15 PF09606.10 CDI80695.1 - 1.7 7.3 19.4 2.2 6.8 19.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal eIF-3_zeta PF05091.12 CDI80695.1 - 1.9 7.4 9.9 2.3 7.1 9.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ETRAMP PF09716.10 CDI80695.1 - 2.6 8.2 0.0 2.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Raftlin PF15250.6 CDI80695.1 - 3.3 6.3 11.3 4.1 6.1 11.3 1.3 1 0 0 1 1 1 0 Raftlin Ferlin_C PF16165.5 CDI80695.1 - 3.7 7.5 5.1 0.98 9.3 2.1 1.5 2 0 0 2 2 2 0 Ferlin C-terminus DUF4407 PF14362.6 CDI80695.1 - 5.6 6.2 13.8 7.1 5.9 13.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ndc1_Nup PF09531.10 CDI80695.1 - 5.6 5.5 13.4 6.7 5.3 13.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PGA2 PF07543.12 CDI80695.1 - 7.3 6.6 19.3 13 5.7 19.3 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 CPSF100_C PF13299.6 CDI80696.1 - 1.9 8.7 5.2 1.4 9.1 2.3 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4179 PF13786.6 CDI80696.1 - 4.7 7.8 10.8 5.4 7.6 1.3 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) ETRAMP PF09716.10 CDI80696.1 - 7.4 6.7 0.0 7.4 6.7 0.0 3.7 4 0 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) Ras PF00071.22 CDI80704.1 - 4.3e-19 68.7 0.0 8.9e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Ras family SUIM_assoc PF16619.5 CDI80704.1 - 0.0042 17.1 0.9 0.0042 17.1 0.9 6.7 3 2 1 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 Roc PF08477.13 CDI80704.1 - 0.17 12.1 0.0 0.17 12.1 0.0 2.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase SR-25 PF10500.9 CDI80704.1 - 2.1 7.9 16.6 0.17 11.5 6.5 3.0 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 CDI80705.1 - 0.0015 18.2 32.8 0.042 13.5 10.4 2.2 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI80705.1 - 0.01 16.1 1.8 0.01 16.1 1.8 2.6 1 1 1 2 2 2 0 Anti-sigma-K factor rskA RAB3GAP2_N PF14655.6 CDI80705.1 - 0.04 13.2 11.9 0.51 9.5 1.7 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus CDH1_2_SANT_HL1 PF18375.1 CDI80705.1 - 0.092 13.4 0.6 9.4 7.0 0.1 2.4 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 DUF2489 PF10675.9 CDI80705.1 - 0.13 12.2 23.1 0.39 10.6 9.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) MAM33 PF02330.16 CDI80705.1 - 0.16 11.9 8.6 0.24 11.3 1.5 2.1 2 0 0 2 2 2 0 Mitochondrial glycoprotein DUF4834 PF16118.5 CDI80705.1 - 0.29 12.1 15.1 0.51 11.3 0.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 CDI80705.1 - 0.4 11.1 8.2 1.2 9.6 0.3 2.4 2 0 0 2 2 2 0 Enhancer of polycomb-like EphA2_TM PF14575.6 CDI80705.1 - 1.5 9.8 4.2 29 5.6 0.3 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF3371 PF11851.8 CDI80705.1 - 2.2 9.4 14.1 2.7 9.1 2.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) HemX PF04375.14 CDI80705.1 - 3.5 6.8 30.3 2.2 7.5 12.8 2.3 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2722 PF10846.8 CDI80705.1 - 4.1 6.2 29.4 0.028 13.4 5.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF4064 PF13273.6 CDI80705.1 - 4.9 7.5 12.8 0.45 10.8 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) PKI PF02827.16 CDI80705.1 - 5.4 7.3 12.1 6.1 7.1 0.9 2.8 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor DUF775 PF05603.12 CDI80705.1 - 6 6.3 24.4 0.6 9.6 10.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF775) DivIC PF04977.15 CDI80705.1 - 7.4 6.4 21.1 7 6.5 4.9 2.6 2 0 0 2 2 2 0 Septum formation initiator TEX13 PF15186.6 CDI80705.1 - 9.5 5.9 18.6 5.2 6.7 7.5 2.5 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family VPS13 PF16908.5 CDI80708.1 - 0.03 14.1 0.2 0.062 13.1 0.2 1.5 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal Totivirus_coat PF05518.11 CDI80708.1 - 2.6 6.0 7.7 4.3 5.3 7.7 1.2 1 0 0 1 1 1 0 Totivirus coat protein DUF3450 PF11932.8 CDI80708.1 - 3 7.1 16.7 0.06 12.6 1.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) HNF-1_N PF04814.13 CDI80711.1 - 1.9 9.1 6.4 0.53 10.9 2.7 1.7 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Sporozoite_P67 PF05642.11 CDI80711.1 - 2.4 6.1 13.7 4 5.4 13.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MGC-24 PF05283.11 CDI80711.1 - 4.6 7.7 12.8 2.6 8.5 6.8 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Band_3_cyto PF07565.13 CDI80716.1 - 0.0075 16.1 0.7 0.0075 16.1 0.7 2.1 2 0 0 2 2 2 1 Band 3 cytoplasmic domain DUF4050 PF13259.6 CDI80716.1 - 1.9 8.8 10.0 1.9 8.8 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Presenilin PF01080.17 CDI80716.1 - 3.7 6.2 11.6 0.67 8.6 1.9 2.4 2 0 0 2 2 2 0 Presenilin SMP PF04927.12 CDI80716.1 - 9.7 6.8 13.3 0.34 11.4 6.2 2.3 2 0 0 2 2 2 0 Seed maturation protein LRR_4 PF12799.7 CDI80717.1 - 9e-37 124.5 44.3 1.4e-09 38.0 1.8 7.4 3 2 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI80717.1 - 3.1e-31 106.9 28.4 7.5e-09 35.2 0.7 5.7 2 1 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 CDI80717.1 - 2.2e-20 72.9 15.0 1.1e-05 25.0 2.2 4.5 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 CDI80717.1 - 5.9e-06 25.9 28.4 0.031 14.3 0.6 7.5 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 CDI80717.1 - 6.7e-06 26.0 28.8 0.7 10.7 0.2 9.2 8 1 0 8 8 8 3 Leucine Rich Repeat DUF2322 PF10084.9 CDI80717.1 - 1 9.4 3.8 5.2 7.2 0.4 3.4 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2322) SPX PF03105.19 CDI80718.1 - 0.61 9.9 9.2 0.84 9.5 9.2 1.3 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI80718.1 - 3.4 6.4 9.8 4 6.2 9.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF755 PF05501.11 CDI80720.1 - 0.0044 17.3 10.0 0.0061 16.8 10.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF755) Stevor PF17410.2 CDI80720.1 - 0.01 15.4 2.4 0.012 15.2 2.4 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Utp21 PF04192.12 CDI80720.1 - 0.012 15.1 1.2 0.013 15.0 1.2 1.2 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain Draxin PF15550.6 CDI80720.1 - 0.024 14.5 3.6 0.027 14.3 3.6 1.0 1 0 0 1 1 1 0 Draxin DUF1635 PF07795.11 CDI80720.1 - 0.11 12.3 4.4 0.13 12.1 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Connexin PF00029.19 CDI80720.1 - 0.14 11.9 0.1 0.18 11.5 0.1 1.1 1 0 0 1 1 1 0 Connexin Apt1 PF10351.9 CDI80720.1 - 0.29 9.9 4.5 0.29 9.9 4.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI80720.1 - 0.41 10.2 4.4 0.39 10.2 4.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RLL PF10036.9 CDI80720.1 - 0.49 10.2 8.2 0.6 9.9 8.2 1.0 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein NST1 PF13945.6 CDI80720.1 - 0.5 10.5 8.1 0.61 10.2 8.1 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 CDI80720.1 - 0.82 8.4 6.4 0.99 8.1 6.4 1.1 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 CDI80720.1 - 6.4 6.3 19.7 3.2 7.3 17.7 1.4 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein FSA_C PF10479.9 CDI80721.1 - 0.46 8.6 2.6 0.58 8.2 2.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Calici_coat PF00915.20 CDI80721.1 - 4.6 6.0 7.4 0.83 8.5 0.0 2.1 2 0 0 2 2 2 0 Calicivirus coat protein Collagen PF01391.18 CDI80722.1 - 0.013 15.2 5.3 0.021 14.5 5.3 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) SPT6_acidic PF14632.6 CDI80722.1 - 0.22 12.1 2.4 0.4 11.3 2.4 1.4 1 0 0 1 1 1 0 Acidic N-terminal SPT6 SDA1 PF05285.12 CDI80722.1 - 1.9 7.8 7.2 2.7 7.3 7.2 1.2 1 0 0 1 1 1 0 SDA1 Apt1 PF10351.9 CDI80722.1 - 4.2 6.1 18.8 10 4.9 19.0 1.4 1 1 0 1 1 1 0 Golgi-body localisation protein domain RAWUL PF16207.5 CDI80723.1 - 0.025 15.2 0.1 0.025 15.2 0.1 2.2 2 0 0 2 2 2 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like Pkinase PF00069.25 CDI80724.1 - 1.4e-68 231.1 0.2 1.7e-68 230.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80724.1 - 5.2e-40 137.4 0.0 6.3e-40 137.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI80724.1 - 1.5e-06 27.7 0.1 2.4e-06 27.1 0.1 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDI80724.1 - 2.3e-06 26.7 0.0 3.7e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDI80724.1 - 0.00021 20.7 1.7 0.44 9.8 0.1 2.9 2 1 0 2 2 2 2 Kinase-like APH PF01636.23 CDI80724.1 - 0.0014 18.6 0.0 0.0092 15.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 CDI80724.1 - 0.009 15.7 1.0 3.3 7.3 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 HP0268 PF18618.1 CDI80724.1 - 0.089 13.2 0.8 6.4 7.3 0.2 2.4 2 0 0 2 2 2 0 HP0268 Presenilin PF01080.17 CDI80727.1 - 7.2 5.3 38.0 7.9 5.1 38.0 1.0 1 0 0 1 1 1 0 Presenilin LSM PF01423.22 CDI80728.1 - 8.1e-20 70.3 0.1 1.2e-19 69.7 0.1 1.3 1 0 0 1 1 1 1 LSM domain SPX PF03105.19 CDI80728.1 - 3e-05 24.1 5.7 3e-05 24.1 5.7 1.1 1 0 0 1 1 1 1 SPX domain Presenilin PF01080.17 CDI80728.1 - 0.00019 20.3 10.5 0.00021 20.2 10.5 1.1 1 0 0 1 1 1 1 Presenilin SR-25 PF10500.9 CDI80728.1 - 0.00021 21.0 17.3 0.0003 20.5 17.3 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DDHD PF02862.17 CDI80728.1 - 0.0016 18.6 5.1 0.0022 18.2 5.1 1.4 1 0 0 1 1 1 1 DDHD domain Zip PF02535.22 CDI80728.1 - 0.0064 15.7 2.4 0.0069 15.6 2.4 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter GREB1 PF15782.5 CDI80728.1 - 0.0079 13.4 19.7 0.0099 13.1 19.7 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Spc7_N PF15402.6 CDI80728.1 - 0.0092 14.3 10.1 0.0093 14.3 10.1 1.1 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 Tim54 PF11711.8 CDI80728.1 - 0.021 13.6 9.0 0.027 13.3 9.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF755 PF05501.11 CDI80728.1 - 0.027 14.7 39.6 0.048 13.9 39.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SpoIIP PF07454.11 CDI80728.1 - 0.033 13.6 11.6 0.042 13.3 11.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PepSY_TM PF03929.16 CDI80728.1 - 0.034 13.8 3.2 0.041 13.5 3.2 1.3 1 0 0 1 1 1 0 PepSY-associated TM region DUF1645 PF07816.11 CDI80728.1 - 0.044 14.3 11.1 0.07 13.7 11.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Ndc1_Nup PF09531.10 CDI80728.1 - 0.087 11.5 16.8 0.11 11.2 16.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Herpes_pp85 PF04637.12 CDI80728.1 - 0.1 11.0 0.8 0.13 10.7 0.8 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) VIT1 PF01988.19 CDI80728.1 - 0.15 11.9 5.1 0.21 11.4 5.1 1.2 1 0 0 1 1 1 0 VIT family SRP-alpha_N PF04086.13 CDI80728.1 - 0.22 11.4 16.0 0.31 10.9 16.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Pex14_N PF04695.13 CDI80728.1 - 0.25 12.0 28.6 0.47 11.1 28.6 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Plasmodium_Vir PF05795.11 CDI80728.1 - 0.3 10.5 8.9 0.39 10.1 8.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Peptidase_S64 PF08192.11 CDI80728.1 - 0.39 9.1 16.4 0.48 8.9 16.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 PAT1 PF09770.9 CDI80728.1 - 0.44 8.8 33.6 0.56 8.4 33.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AF-4 PF05110.13 CDI80728.1 - 0.48 8.5 28.4 0.62 8.1 28.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Scs3p PF10261.9 CDI80728.1 - 0.55 9.7 6.4 0.73 9.3 6.4 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM CCDC53 PF10152.9 CDI80728.1 - 0.57 10.6 17.8 0.89 10.0 17.1 1.7 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Macoilin PF09726.9 CDI80728.1 - 0.85 8.1 16.7 1.2 7.6 16.7 1.1 1 0 0 1 1 1 0 Macoilin family Dmrt1 PF12374.8 CDI80728.1 - 0.96 9.9 9.6 1.6 9.3 0.7 2.3 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 Apt1 PF10351.9 CDI80728.1 - 1.2 7.9 15.6 1.6 7.5 15.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CobT PF06213.12 CDI80728.1 - 1.4 8.3 25.7 2.2 7.6 25.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1387 PF07139.11 CDI80728.1 - 1.9 8.2 21.1 2.6 7.7 21.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) SLC12 PF03522.15 CDI80728.1 - 1.9 7.4 19.0 2.5 7.0 19.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DDRGK PF09756.9 CDI80728.1 - 2.2 7.9 23.1 3 7.4 23.1 1.1 1 0 0 1 1 1 0 DDRGK domain PIG-S PF10510.9 CDI80728.1 - 2.3 7.0 17.6 2.8 6.6 17.6 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein V_ATPase_I PF01496.19 CDI80728.1 - 2.8 5.7 17.9 3.6 5.4 17.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 CDI80728.1 - 3.3 5.7 17.6 4 5.4 17.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4770 PF15994.5 CDI80728.1 - 3.8 7.7 20.0 5.8 7.1 20.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) OATP PF03137.20 CDI80728.1 - 4 5.6 6.8 5.1 5.2 6.8 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folliculin PF11704.8 CDI80728.1 - 4.6 7.1 14.8 8.3 6.3 14.8 1.5 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Ribonuc_P_40 PF08584.11 CDI80728.1 - 4.6 6.4 13.5 6.4 6.0 13.5 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit CLN3 PF02487.17 CDI80728.1 - 4.8 6.1 13.9 5.8 5.9 13.9 1.2 1 0 0 1 1 1 0 CLN3 protein TFIIA PF03153.13 CDI80728.1 - 5.8 6.8 50.5 8.6 6.2 50.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tam41_Mmp37 PF09139.11 CDI80728.1 - 6.1 6.2 16.3 8.5 5.7 16.3 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF4407 PF14362.6 CDI80728.1 - 6.3 6.1 20.6 8.7 5.6 20.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ofd1_CTDD PF10637.9 CDI80728.1 - 6.8 6.0 12.3 8.4 5.7 12.3 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Lin-8 PF03353.15 CDI80728.1 - 7.3 6.1 30.9 5.9 6.4 29.3 1.5 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DAG_kinase_N PF14513.6 CDI80728.1 - 7.7 6.7 21.4 8.3 6.6 20.0 1.6 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Hydin_ADK PF17213.3 CDI80728.1 - 8 6.7 17.0 13 6.0 17.0 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Gti1_Pac2 PF09729.9 CDI80728.1 - 8.2 6.5 16.9 13 5.8 16.9 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Calici_coat_C PF08435.11 CDI80728.1 - 8.8 5.8 14.5 12 5.4 14.5 1.1 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal Neur_chan_memb PF02932.16 CDI80728.1 - 9 6.3 17.3 14 5.7 17.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PPL5 PF18168.1 CDI80728.1 - 9.5 5.4 14.0 13 5.0 14.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 SUIM_assoc PF16619.5 CDI80729.1 - 0.0007 19.6 0.0 0.0007 19.6 0.0 7.9 4 2 3 7 7 3 1 Unstructured region C-term to UIM in Ataxin3 DUF4746 PF15928.5 CDI80729.1 - 0.0022 17.5 2.4 0.0022 17.5 2.4 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4746) LMBR1 PF04791.16 CDI80729.1 - 0.099 11.5 7.6 0.19 10.6 7.6 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein SID-1_RNA_chan PF13965.6 CDI80729.1 - 0.22 9.9 8.7 0.075 11.4 6.1 1.5 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 CDI80729.1 - 0.35 11.9 25.8 6.3 7.8 15.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Nucleo_P87 PF07267.11 CDI80729.1 - 0.71 8.7 16.2 1.3 7.8 16.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM176 PF14851.6 CDI80729.1 - 0.79 9.4 21.7 0.17 11.6 11.6 3.1 3 0 0 3 3 3 0 FAM176 family DUF1980 PF09323.10 CDI80729.1 - 1.1 9.1 11.8 0.64 9.9 8.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) SARAF PF06682.12 CDI80729.1 - 3.1 7.3 18.0 1.4 8.5 12.1 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis CLN3 PF02487.17 CDI80729.1 - 3.4 6.6 21.3 0.072 12.1 8.4 2.9 2 1 1 3 3 3 0 CLN3 protein Eapp_C PF10238.9 CDI80729.1 - 4.7 7.3 22.0 2.3 8.3 9.7 3.4 3 0 0 3 3 3 0 E2F-associated phosphoprotein Afi1 PF07792.12 CDI80729.1 - 5.5 7.5 23.8 0.38 11.2 13.5 3.0 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SLC12 PF03522.15 CDI80729.1 - 7 5.6 21.9 2.7 6.9 17.6 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Cellulose_synt PF03552.14 CDI80729.1 - 7.1 5.0 5.7 12 4.2 5.7 1.3 1 0 0 1 1 1 0 Cellulose synthase Apt1 PF10351.9 CDI80730.1 - 0.0014 17.6 6.3 0.0014 17.6 6.3 1.7 2 0 0 2 2 2 1 Golgi-body localisation protein domain Presenilin PF01080.17 CDI80730.1 - 1.1 7.9 8.9 2.2 6.9 8.9 1.4 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CDI80730.1 - 2.3 6.3 6.9 3.2 5.8 6.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Tmemb_cc2 PF10267.9 CDI80730.1 - 5.3 6.1 10.9 10 5.2 10.9 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein GREB1 PF15782.5 CDI80730.1 - 5.4 4.0 11.5 7.8 3.5 11.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3807 PF12720.7 CDI80730.1 - 5.7 7.2 11.0 0.37 11.0 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Helicase_C PF00271.31 CDI80731.1 - 1.9e-30 105.5 0.0 2.8e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDI80731.1 - 0.17 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Peptidase_M76 PF09768.9 CDI80732.1 - 1.4e-31 109.6 3.2 2.3e-22 79.6 0.0 2.4 2 1 0 2 2 2 2 Peptidase M76 family RskA PF10099.9 CDI80732.1 - 0.14 12.4 0.1 0.14 12.4 0.1 4.7 2 2 1 3 3 3 0 Anti-sigma-K factor rskA WTX PF09422.10 CDI80732.1 - 0.24 10.4 23.9 0.069 12.2 11.0 2.2 2 0 0 2 2 2 0 WTX protein NinG PF05766.12 CDI80732.1 - 1.4 8.8 16.6 0.049 13.6 10.1 1.8 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein Spt20 PF12090.8 CDI80733.1 - 0.0043 16.7 4.3 0.0043 16.7 4.3 4.9 4 1 0 4 4 4 2 Spt20 family Filament_head PF04732.14 CDI80733.1 - 0.11 13.3 10.6 3.7 8.5 0.9 2.8 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region FAM60A PF15396.6 CDI80733.1 - 5.3 7.0 15.6 2.7 7.9 2.5 4.0 4 0 0 4 4 4 0 Protein Family FAM60A TPR_1 PF00515.28 CDI80734.1 - 9.6e-10 37.9 6.3 6.9e-05 22.5 2.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDI80734.1 - 5.2e-09 35.6 10.2 2.2e-07 30.5 1.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 CDI80734.1 - 2.1e-08 33.6 8.8 0.00012 22.0 3.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI80734.1 - 3.5e-08 33.5 6.3 3.2e-07 30.4 6.3 2.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI80734.1 - 0.00016 21.6 3.5 0.025 14.8 0.8 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI80734.1 - 0.0013 18.7 3.2 0.052 13.6 0.5 2.7 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 CDI80734.1 - 0.011 15.7 5.1 2.5 8.3 0.4 3.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI80734.1 - 0.014 16.1 3.4 0.014 16.1 3.4 6.5 4 2 3 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDI80734.1 - 0.043 14.2 3.6 0.37 11.3 0.8 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NAM-associated PF14303.6 CDI80734.1 - 4.4 8.0 0.0 4.4 8.0 0.0 7.4 6 3 1 7 7 7 0 No apical meristem-associated C-terminal domain 2TM PF13239.6 CDI80738.1 - 0.13 12.5 0.0 0.13 12.5 0.0 3.7 4 1 0 4 4 4 0 2TM domain RILP PF11461.8 CDI80739.1 - 5e-06 26.6 1.2 0.0027 17.9 0.1 3.9 3 0 0 3 3 3 1 Rab interacting lysosomal protein HAP1_N PF04849.13 CDI80739.1 - 0.0024 17.1 1.3 0.0024 17.1 1.3 4.8 4 1 1 5 5 5 1 HAP1 N-terminal conserved region TSC22 PF01166.18 CDI80739.1 - 0.0033 17.7 18.7 0.31 11.4 0.3 5.5 6 0 0 6 6 4 2 TSC-22/dip/bun family ERM PF00769.19 CDI80739.1 - 0.0064 16.3 6.6 0.0064 16.3 6.6 5.1 4 1 0 5 5 4 1 Ezrin/radixin/moesin family CENP-F_leu_zip PF10473.9 CDI80739.1 - 0.011 15.7 3.1 0.011 15.7 3.1 6.5 5 2 1 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 CDI80739.1 - 0.018 14.8 0.1 0.018 14.8 0.1 7.9 6 2 2 8 8 8 0 Septum formation initiator DUF4988 PF16378.5 CDI80739.1 - 0.024 14.3 2.2 2.1 8.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function bZIP_1 PF00170.21 CDI80739.1 - 0.056 13.5 25.4 0.44 10.7 0.4 5.8 5 0 0 5 5 5 0 bZIP transcription factor HALZ PF02183.18 CDI80739.1 - 0.56 10.5 30.3 1.5 9.1 0.3 6.7 6 1 1 7 7 7 0 Homeobox associated leucine zipper V_ATPase_I PF01496.19 CDI80739.1 - 0.83 7.5 12.1 0.3 9.0 0.4 3.2 2 1 1 3 3 3 0 V-type ATPase 116kDa subunit family Scaffolding_pro PF11418.8 CDI80739.1 - 0.9 10.1 4.7 22 5.7 0.3 3.7 4 0 0 4 4 4 0 Phi29 scaffolding protein FapA PF03961.13 CDI80739.1 - 1.4 7.4 22.7 0.15 10.6 1.1 3.3 1 1 1 3 3 3 0 Flagellar Assembly Protein A DUF4618 PF15397.6 CDI80739.1 - 4.2 6.7 26.9 5 6.5 3.7 5.0 4 1 0 4 4 4 0 Domain of unknown function (DUF4618) NPV_P10 PF05531.12 CDI80739.1 - 4.7 7.7 9.3 17 5.9 0.2 4.7 3 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein IFT57 PF10498.9 CDI80739.1 - 9.1 5.1 24.0 0.89 8.5 12.4 3.4 3 1 0 3 3 3 0 Intra-flagellar transport protein 57 PI3_PI4_kinase PF00454.27 CDI80741.1 - 2.4e-14 53.8 12.7 8e-10 38.9 4.5 3.3 2 1 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF2722 PF10846.8 CDI80741.1 - 0.0002 20.5 5.3 0.0002 20.5 5.3 5.1 4 1 0 4 4 4 2 Protein of unknown function (DUF2722) RskA PF10099.9 CDI80741.1 - 0.00074 19.9 6.6 0.00074 19.9 6.6 6.9 6 2 1 7 7 7 3 Anti-sigma-K factor rskA EPL1 PF10513.9 CDI80741.1 - 0.27 11.6 44.0 2.1 8.7 7.7 4.4 4 0 0 4 4 4 0 Enhancer of polycomb-like RLL PF10036.9 CDI80741.1 - 3.5 7.4 40.3 0.06 13.2 4.0 4.5 4 0 0 4 4 4 0 RNA transcription, translation and transport factor protein Peptidase_S49_N PF08496.10 CDI80741.1 - 3.9 7.5 29.8 1.5 8.8 2.1 4.3 4 0 0 4 4 4 0 Peptidase family S49 N-terminal Utp14 PF04615.13 CDI80742.1 - 0.001 17.8 1.8 0.001 17.8 1.8 8.0 2 1 4 7 7 7 2 Utp14 protein N6_N4_Mtase PF01555.18 CDI80742.1 - 4.2 7.0 12.5 91 2.6 0.0 4.1 3 2 0 4 4 4 0 DNA methylase DUF572 PF04502.13 CDI80745.1 - 1.1 8.9 55.7 1.4 8.5 55.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Yip1 PF04893.17 CDI80746.1 - 0.053 13.2 2.0 1.8 8.3 0.7 3.1 2 1 1 3 3 3 0 Yip1 domain Utp12 PF04003.12 CDI80747.1 - 2.5e-10 40.6 2.7 5.4e-10 39.5 2.7 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ketoacyl-synt PF00109.26 CDI80748.1 - 2.6e-36 125.5 2.8 6.8e-36 124.1 1.3 2.0 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDI80748.1 - 1.3e-27 96.1 1.8 2.4e-24 85.6 1.8 2.5 1 1 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CDI80748.1 - 0.00046 19.6 1.4 0.0028 17.1 0.7 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CDI80748.1 - 0.015 15.2 3.5 4.5 7.2 0.5 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III CactinC_cactus PF09732.9 CDI80750.1 - 2.8e-54 182.4 8.4 2.8e-54 182.4 8.4 1.7 2 0 0 2 2 2 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 CDI80750.1 - 1.9e-47 161.6 2.2 1.9e-47 161.6 2.2 2.5 2 0 0 2 2 2 1 Conserved mid region of cactin Thioesterase PF00975.20 CDI80751.1 - 4.9e-15 56.3 0.0 1.6e-14 54.6 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CDI80751.1 - 3e-06 28.0 0.4 3.7e-06 27.7 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDI80751.1 - 0.00068 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PE-PPE PF08237.11 CDI80751.1 - 0.029 13.9 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain LIDHydrolase PF10230.9 CDI80751.1 - 0.065 12.8 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF726 PF05277.12 CDI80751.1 - 0.11 11.4 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF900 PF05990.12 CDI80751.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Ribosomal_S4e PF00900.20 CDI80752.1 - 9.7e-32 108.7 0.2 1.4e-30 105.0 0.2 2.4 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 CDI80752.1 - 5.9e-25 86.7 0.2 1e-24 85.9 0.2 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 CDI80752.1 - 1.1e-18 67.0 10.3 3.4e-18 65.4 9.4 2.1 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.25 CDI80752.1 - 3.4e-06 26.7 0.0 7.1e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 CDI80752.1 - 6.8e-06 25.9 1.2 6.8e-06 25.9 1.2 2.4 3 0 0 3 3 3 1 KOW motif IPK PF03770.16 CDI80753.1 - 2e-25 89.8 0.0 1.7e-24 86.8 0.0 2.0 1 1 0 1 1 1 1 Inositol polyphosphate kinase AMP-binding PF00501.28 CDI80755.1 - 2e-37 128.8 0.0 2.9e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme SR-25 PF10500.9 CDI80755.1 - 0.0023 17.6 0.1 0.0023 17.6 0.1 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Serglycin PF04360.12 CDI80755.1 - 0.0049 16.8 4.3 0.0092 15.9 4.3 1.4 1 0 0 1 1 1 1 Serglycin DUF4050 PF13259.6 CDI80755.1 - 0.019 15.3 0.5 0.052 13.9 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) SIM_C PF06621.12 CDI80755.1 - 0.065 13.3 0.5 0.12 12.4 0.1 1.5 2 0 0 2 2 2 0 Single-minded protein C-terminus SUIM_assoc PF16619.5 CDI80755.1 - 0.11 12.6 13.8 0.42 10.7 5.0 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AIG1 PF04548.16 CDI80755.1 - 0.65 9.3 3.3 0.32 10.3 0.2 1.8 2 0 0 2 2 2 0 AIG1 family ACDC PF14733.6 CDI80756.1 - 2.8e-09 37.2 0.3 2.8e-09 37.2 0.3 2.0 2 0 0 2 2 2 1 AP2-coincident C-terminal AAA_23 PF13476.6 CDI80756.1 - 0.057 13.9 14.4 0.083 13.4 14.4 1.3 1 0 0 1 1 1 0 AAA domain SID-1_RNA_chan PF13965.6 CDI80756.1 - 0.62 8.4 3.2 0.9 7.9 3.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 HAUS6_N PF14661.6 CDI80756.1 - 1.4 8.5 19.8 2.6 7.6 19.8 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4746 PF15928.5 CDI80756.1 - 2.5 7.4 10.7 4.2 6.7 10.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CDI80756.1 - 3.1 6.6 8.4 6.3 5.6 8.4 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) Apt1 PF10351.9 CDI80756.1 - 4.3 6.1 21.3 0.85 8.4 8.8 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain XRN_M PF17846.1 CDI80756.1 - 5.1 5.9 12.0 10 5.0 12.0 1.5 1 0 0 1 1 1 0 Xrn1 helical domain Sin_N PF04801.13 CDI80756.1 - 6.2 5.9 38.6 15 4.7 38.6 1.6 1 0 0 1 1 1 0 Sin-like protein conserved region YABBY PF04690.13 CDI80756.1 - 9.3 6.8 14.9 38 4.8 14.9 2.0 1 0 0 1 1 1 0 YABBY protein CPSF_A PF03178.15 CDI80757.1 - 2.5e-51 174.9 0.0 3.1e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 CPSF A subunit region DUF2154 PF09922.9 CDI80757.1 - 0.029 14.3 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Cell wall-active antibiotics response 4TMS YvqF BPL_LplA_LipB PF03099.19 CDI80759.1 - 1.1e-07 31.8 0.9 3.5e-06 27.0 0.0 3.1 3 1 0 3 3 3 1 Biotin/lipoate A/B protein ligase family Otopetrin PF03189.13 CDI80759.1 - 0.00011 21.1 1.2 0.00011 21.1 1.2 3.0 3 0 0 3 3 3 1 Otopetrin DUF4746 PF15928.5 CDI80759.1 - 0.0011 18.5 19.3 0.0011 18.5 19.3 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4746) CNDH2_C PF16858.5 CDI80759.1 - 0.0023 17.9 14.1 0.0023 17.9 14.1 2.5 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term RLL PF10036.9 CDI80759.1 - 0.0085 16.0 6.7 0.0085 16.0 6.7 4.9 3 1 2 5 5 3 1 RNA transcription, translation and transport factor protein CDC45 PF02724.14 CDI80759.1 - 0.22 9.8 37.1 0.64 8.2 3.4 3.0 3 0 0 3 3 3 0 CDC45-like protein Zip PF02535.22 CDI80759.1 - 0.37 10.0 25.8 0.045 13.0 10.7 3.1 3 0 0 3 3 3 0 ZIP Zinc transporter Velvet PF11754.8 CDI80759.1 - 1.2 9.1 51.8 0.044 13.7 3.3 3.7 3 1 0 3 3 3 0 Velvet factor SID-1_RNA_chan PF13965.6 CDI80759.1 - 2.7 6.3 21.1 0.6 8.5 6.7 2.8 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 Pox_Ag35 PF03286.14 CDI80759.1 - 4.6 7.0 28.5 2.8 7.7 2.2 3.2 3 0 0 3 3 3 0 Pox virus Ag35 surface protein MRP-S26 PF14943.6 CDI80759.1 - 7.9 6.3 44.8 0.36 10.7 21.0 2.8 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 Diphthamide_syn PF01866.17 CDI80760.1 - 7.2e-59 199.7 0.0 3.2e-44 151.6 0.0 2.9 3 0 0 3 3 3 2 Putative diphthamide synthesis protein DUF908 PF06012.12 CDI80760.1 - 0.026 14.0 26.1 0.37 10.2 18.6 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) CPSF100_C PF13299.6 CDI80760.1 - 3 8.0 8.1 1.1 9.5 1.5 2.8 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 CDI80760.1 - 3.3 6.4 16.1 9.8 4.8 12.9 2.1 2 0 0 2 2 2 0 Presenilin Cwf_Cwc_15 PF04889.12 CDI80760.1 - 3.4 7.4 14.2 0.65 9.7 6.3 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RPAP1_C PF08620.10 CDI80762.1 - 9.7e-20 70.5 0.1 3.5e-19 68.7 0.1 2.1 1 0 0 1 1 1 1 RPAP1-like, C-terminal IQ PF00612.27 CDI80763.1 - 0.093 12.6 0.3 0.21 11.5 0.3 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif TPR_9 PF13371.6 CDI80765.1 - 2.3e-08 34.1 0.9 2.3e-08 34.1 0.9 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI80765.1 - 3e-07 30.9 2.3 3e-07 30.9 2.3 2.1 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI80765.1 - 7.6e-06 25.6 0.3 0.16 12.2 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI80765.1 - 1.4e-05 24.7 0.2 0.036 13.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI80765.1 - 0.00085 19.9 0.2 0.00085 19.9 0.2 4.3 4 1 1 5 5 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDI80765.1 - 0.0022 18.6 0.3 0.0022 18.6 0.3 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI80765.1 - 0.0084 16.2 0.1 0.17 12.2 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.8 CDI80765.1 - 0.011 14.6 1.1 0.012 14.5 0.0 1.6 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 CDI80765.1 - 0.013 15.8 0.4 0.051 14.0 0.4 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI80765.1 - 0.017 15.3 2.2 0.062 13.5 1.1 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDI80765.1 - 0.028 15.0 0.6 0.26 12.0 0.1 3.1 3 0 0 3 3 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI80765.1 - 0.054 13.6 0.1 3.7 7.7 0.0 2.9 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 CDI80765.1 - 0.091 13.4 0.3 0.091 13.4 0.3 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Abhydrolase_2 PF02230.16 CDI80767.1 - 1.4e-49 168.9 0.0 2.9e-49 167.8 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CDI80767.1 - 6.3e-06 26.9 0.1 1.6e-05 25.6 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 CDI80767.1 - 8.7e-05 22.1 0.9 0.00014 21.4 0.0 1.8 2 1 1 3 3 3 1 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 CDI80767.1 - 0.00034 20.3 0.0 0.0042 16.8 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CDI80767.1 - 0.00038 20.4 0.0 0.0021 18.0 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDI80767.1 - 0.0016 18.0 0.1 0.38 10.2 0.0 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDI80767.1 - 0.0032 16.7 1.9 0.084 12.1 0.1 2.7 3 1 0 3 3 3 1 Serine aminopeptidase, S33 FSH1 PF03959.13 CDI80767.1 - 0.0048 16.6 0.0 0.011 15.4 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 CDI80767.1 - 0.056 12.1 0.1 0.089 11.5 0.1 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF2920 PF11144.8 CDI80767.1 - 0.075 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) SET PF00856.28 CDI80768.1 - 1.3e-06 28.9 0.0 0.00013 22.4 0.0 2.9 2 1 0 2 2 2 1 SET domain Abhydrolase_3 PF07859.13 CDI80768.1 - 0.32 10.8 8.5 0.34 10.7 0.8 3.2 3 0 0 3 3 3 0 alpha/beta hydrolase fold SKIP_SNW PF02731.15 CDI80769.1 - 2.7e-69 231.9 1.5 2.7e-69 231.9 1.5 2.9 3 0 0 3 3 3 1 SKIP/SNW domain Kelch_4 PF13418.6 CDI80770.1 - 0.003 17.5 0.6 0.0089 16.0 0.1 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI80770.1 - 0.014 15.6 3.5 2.1 8.7 0.0 4.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI80770.1 - 0.09 12.8 1.6 0.4 10.7 0.0 3.0 3 0 0 3 3 3 0 Kelch motif RskA PF10099.9 CDI80771.1 - 3.7e-06 27.3 32.3 0.0095 16.3 0.8 5.3 3 1 1 4 4 4 3 Anti-sigma-K factor rskA PgaD PF13994.6 CDI80771.1 - 0.082 13.0 0.3 0.082 13.0 0.3 2.4 3 0 0 3 3 3 0 PgaD-like protein Sacchrp_dh_C PF16653.5 CDI80771.1 - 0.088 12.9 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain CoA_binding_3 PF13727.6 CDI80771.1 - 0.12 12.4 0.0 0.12 12.4 0.0 2.4 3 0 0 3 3 3 0 CoA-binding domain RIFIN PF02009.16 CDI80771.1 - 0.25 11.2 6.6 4 7.2 3.8 2.4 2 0 0 2 2 2 0 Rifin PIP5K PF01504.18 CDI80773.1 - 1.2 8.3 20.1 1.2 8.3 1.3 3.7 3 0 0 3 3 3 0 Phosphatidylinositol-4-phosphate 5-Kinase PAT1 PF09770.9 CDI80774.1 - 4.9 5.3 19.0 6.2 5.0 19.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peroxin-22 PF12827.7 CDI80775.1 - 0.025 14.5 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family Sec66 PF09802.9 CDI80776.1 - 8.6e-07 28.7 10.4 8.6e-07 28.7 10.4 2.9 2 1 1 3 3 3 1 Preprotein translocase subunit Sec66 DRMBL PF07522.14 CDI80778.1 - 4.6e-13 49.3 0.0 6.4e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 CDI80778.1 - 4e-06 26.7 0.0 8.5e-06 25.6 0.0 1.5 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 CDI80778.1 - 0.074 12.6 0.0 0.51 9.8 0.0 2.0 2 0 0 2 2 2 0 Beta-lactamase superfamily domain CATSPERG PF15064.6 CDI80778.1 - 0.14 9.9 0.0 0.18 9.6 0.0 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit gamma DUF202 PF02656.15 CDI80779.1 - 5.5e-12 45.9 6.8 5.5e-12 45.9 6.8 4.2 4 1 0 4 4 4 1 Domain of unknown function (DUF202) VTC PF09359.10 CDI80779.1 - 9e-10 38.4 0.0 1.2e-05 24.9 0.0 2.9 2 1 0 2 2 2 2 VTC domain SPX PF03105.19 CDI80779.1 - 8.9e-08 32.4 16.6 8.9e-08 32.4 16.6 5.4 3 1 1 4 4 4 2 SPX domain EPL1 PF10513.9 CDI80779.1 - 3.4 8.0 20.1 1.9 8.8 4.8 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like Zip PF02535.22 CDI80779.1 - 7.5 5.7 11.3 2.4 7.3 1.2 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter DUF21 PF01595.20 CDI80780.1 - 0.005 16.6 0.0 0.5 10.1 0.0 2.3 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain Band_3_cyto PF07565.13 CDI80780.1 - 0.14 11.9 12.6 0.033 14.0 1.8 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CSG2 PF16965.5 CDI80780.1 - 2.2 7.2 4.2 13 4.6 2.0 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator SSP160 PF06933.11 CDI80780.1 - 3.2 5.8 19.1 5.6 5.0 19.1 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ALMT PF11744.8 CDI80780.1 - 5.6 5.7 8.4 5.6 5.7 4.2 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Ashwin PF15323.6 CDI80780.1 - 7.7 6.5 21.7 1.2 9.1 15.4 2.1 2 0 0 2 2 2 0 Developmental protein Apc15p PF05841.11 CDI80780.1 - 8.7 7.2 32.6 0.18 12.6 0.6 3.2 2 1 1 3 3 3 0 Apc15p protein Mem_trans PF03547.18 CDI80780.1 - 9.1 4.5 7.1 5.3 5.3 5.1 1.6 2 0 0 2 2 2 0 Membrane transport protein TAF PF02969.17 CDI80782.1 - 0.12 12.5 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) PH_RBD PF12068.8 CDI80784.1 - 2.9 7.3 7.9 0.93 8.9 0.1 2.9 3 0 0 3 3 3 0 Rab-binding domain (RBD) SUIM_assoc PF16619.5 CDI80785.1 - 0.0024 17.9 0.9 0.0024 17.9 0.9 2.0 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 His_Phos_1 PF00300.22 CDI80785.1 - 0.033 13.9 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) DUF2489 PF10675.9 CDI80785.1 - 0.46 10.4 4.0 0.91 9.4 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) SR-25 PF10500.9 CDI80785.1 - 2.6 7.6 12.0 3.5 7.2 9.0 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein K_channel_TID PF07941.11 CDI80785.1 - 6.3 7.3 28.1 3.9 8.0 11.6 2.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain TAXi_C PF14541.6 CDI80786.1 - 3.4e-18 65.9 0.0 4.6e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.23 CDI80786.1 - 7.4e-06 25.6 0.0 1.3e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Radial_spoke_3 PF06098.11 CDI80787.1 - 2.4e-45 155.0 14.5 1e-44 153.0 14.5 1.8 1 1 0 1 1 1 1 Radial spoke protein 3 SUIM_assoc PF16619.5 CDI80787.1 - 5.8 7.0 16.7 0.074 13.1 3.1 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2052 PF09747.9 CDI80788.1 - 0.023 14.9 23.1 0.025 14.7 23.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RNA_pol_Rpc4 PF05132.14 CDI80788.1 - 0.033 14.6 13.9 0.037 14.5 13.9 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 CLN3 PF02487.17 CDI80788.1 - 0.036 13.1 13.9 0.039 13.0 13.9 1.0 1 0 0 1 1 1 0 CLN3 protein DUF2126 PF09899.9 CDI80788.1 - 0.038 12.1 12.6 0.046 11.8 12.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4746 PF15928.5 CDI80788.1 - 0.07 12.5 17.0 0.079 12.4 17.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.12 CDI80788.1 - 0.079 12.8 21.4 0.089 12.6 21.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RPN2_C PF18004.1 CDI80788.1 - 0.079 12.9 16.8 0.099 12.6 16.8 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Caldesmon PF02029.15 CDI80788.1 - 0.14 10.9 22.3 0.14 10.8 22.3 1.0 1 0 0 1 1 1 0 Caldesmon eIF-3_zeta PF05091.12 CDI80788.1 - 0.17 10.8 23.5 0.18 10.7 23.5 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CCSAP PF15748.5 CDI80788.1 - 0.19 11.9 22.5 0.22 11.7 22.5 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated V_ATPase_I PF01496.19 CDI80788.1 - 0.26 9.2 25.1 0.29 9.0 25.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pex14_N PF04695.13 CDI80788.1 - 0.34 11.5 23.6 0.44 11.2 23.6 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.9 CDI80788.1 - 0.4 10.8 17.5 0.44 10.6 17.5 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family CCDC53 PF10152.9 CDI80788.1 - 0.42 11.0 18.1 0.55 10.7 18.1 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex CDC45 PF02724.14 CDI80788.1 - 0.43 8.8 21.1 0.45 8.7 21.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI80788.1 - 0.43 9.3 26.6 0.5 9.1 26.6 1.0 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 CDI80788.1 - 0.45 9.2 16.7 0.53 9.0 16.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SpoIIP PF07454.11 CDI80788.1 - 0.49 9.8 21.7 0.69 9.3 21.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CSG2 PF16965.5 CDI80788.1 - 0.53 9.2 10.7 0.63 8.9 10.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator PIP5K PF01504.18 CDI80788.1 - 0.67 9.1 16.8 0.82 8.8 16.8 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase TRAP_alpha PF03896.16 CDI80788.1 - 0.67 9.1 11.6 0.95 8.6 11.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PNISR PF15996.5 CDI80788.1 - 0.72 10.1 26.2 0.88 9.8 26.2 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR F-protein PF00469.20 CDI80788.1 - 0.77 9.3 17.4 0.94 9.0 17.4 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Spore_coat_CotO PF14153.6 CDI80788.1 - 0.99 9.3 26.3 1.1 9.1 26.3 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Afi1 PF07792.12 CDI80788.1 - 1.1 9.7 23.2 1.5 9.3 23.2 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4045 PF13254.6 CDI80788.1 - 1.2 8.8 18.8 1.3 8.6 18.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Ribonuc_P_40 PF08584.11 CDI80788.1 - 1.3 8.3 13.9 1.5 8.0 13.9 1.0 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit PAT1 PF09770.9 CDI80788.1 - 1.5 7.0 32.9 1.6 6.9 32.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 YABBY PF04690.13 CDI80788.1 - 1.5 9.3 16.3 2 8.9 16.3 1.2 1 0 0 1 1 1 0 YABBY protein TFIIA PF03153.13 CDI80788.1 - 1.5 8.7 45.0 1.9 8.4 45.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI80788.1 - 1.6 8.7 17.5 1.8 8.5 17.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDM10 PF12519.8 CDI80788.1 - 1.6 7.5 18.2 1.9 7.3 18.2 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SID-1_RNA_chan PF13965.6 CDI80788.1 - 1.7 7.0 11.8 1.9 6.8 11.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.12 CDI80788.1 - 1.9 7.4 15.2 2.2 7.2 15.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI80788.1 - 2 8.4 19.2 2.3 8.1 19.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 CDI80788.1 - 2 7.3 24.9 2.2 7.2 24.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 CDI80788.1 - 2 7.5 21.9 2.3 7.4 21.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2828 PF11443.8 CDI80788.1 - 2.1 6.3 22.1 2.4 6.1 22.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S64 PF08192.11 CDI80788.1 - 2.1 6.7 20.5 2.6 6.5 20.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 CobT PF06213.12 CDI80788.1 - 2.2 7.6 34.4 2.7 7.3 34.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDRGK PF09756.9 CDI80788.1 - 2.4 7.7 28.7 3.4 7.2 28.7 1.3 1 0 0 1 1 1 0 DDRGK domain Raftlin PF15250.6 CDI80788.1 - 2.5 6.7 21.4 3 6.5 21.4 1.0 1 0 0 1 1 1 0 Raftlin Kei1 PF08552.11 CDI80788.1 - 2.6 7.9 12.5 3.2 7.6 12.5 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Endostatin PF06482.11 CDI80788.1 - 3.2 7.1 20.5 3.4 7.0 20.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF1682 PF07946.14 CDI80788.1 - 3.2 6.9 17.3 3.7 6.7 17.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) ALMT PF11744.8 CDI80788.1 - 3.4 6.4 22.8 3.9 6.2 22.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DHHW PF14286.6 CDI80788.1 - 3.9 6.7 10.6 4.7 6.4 10.6 1.0 1 0 0 1 1 1 0 DHHW protein CAC1F_C PF16885.5 CDI80788.1 - 4.4 6.9 17.0 4.7 6.8 17.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Velvet PF11754.8 CDI80788.1 - 4.7 7.1 20.8 5.5 6.9 20.8 1.1 1 0 0 1 1 1 0 Velvet factor Rtf2 PF04641.12 CDI80788.1 - 5.1 6.4 19.2 5.9 6.2 19.2 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Folliculin PF11704.8 CDI80788.1 - 6.2 6.7 15.2 7.7 6.4 15.2 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Borrelia_P83 PF05262.11 CDI80788.1 - 6.6 5.1 22.9 6.9 5.0 22.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein NOA36 PF06524.12 CDI80788.1 - 6.8 5.9 19.8 8 5.7 19.8 1.0 1 0 0 1 1 1 0 NOA36 protein NPR3 PF03666.13 CDI80788.1 - 7.1 5.3 23.6 8 5.1 23.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TCP PF03634.13 CDI80788.1 - 7.1 7.2 26.7 8.4 6.9 26.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor DUF4228 PF14009.6 CDI80788.1 - 7.4 6.9 12.2 9.8 6.5 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) AAA_11 PF13086.6 CDI80788.1 - 7.6 6.2 25.0 9 6.0 25.0 1.0 1 0 0 1 1 1 0 AAA domain PPP4R2 PF09184.11 CDI80788.1 - 7.9 6.0 25.0 8.8 5.8 25.0 1.0 1 0 0 1 1 1 0 PPP4R2 TT_ORF1 PF02956.14 CDI80788.1 - 9.2 4.8 17.6 10 4.6 17.6 1.0 1 0 0 1 1 1 0 TT viral orf 1 XRN_M PF17846.1 CDI80788.1 - 9.5 5.0 16.2 10 4.9 16.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Paf1 PF03985.13 CDI80788.1 - 9.5 5.1 28.5 11 4.9 28.5 1.1 1 0 0 1 1 1 0 Paf1 Collagen PF01391.18 CDI80789.1 - 7.5 6.4 10.4 4.4 7.1 3.1 3.2 3 0 0 3 3 3 0 Collagen triple helix repeat (20 copies) Macoilin PF09726.9 CDI80790.1 - 3.7e-07 29.1 21.4 4.4e-07 28.9 21.4 1.1 1 0 0 1 1 1 1 Macoilin family RBFA PF02033.18 CDI80790.1 - 0.0042 17.5 0.0 0.0042 17.5 0.0 2.5 3 0 0 3 3 3 1 Ribosome-binding factor A DUF2407 PF10302.9 CDI80790.1 - 0.085 13.4 6.3 2.1 8.9 0.0 3.4 2 1 1 3 3 3 0 DUF2407 ubiquitin-like domain HNOBA PF07701.14 CDI80790.1 - 1.2 8.5 9.7 0.4 10.1 4.0 2.2 2 0 0 2 2 2 0 Heme NO binding associated 7tm_6 PF02949.20 CDI80790.1 - 1.8 7.5 4.0 3.5 6.6 4.0 1.4 1 0 0 1 1 1 0 7tm Odorant receptor Apt1 PF10351.9 CDI80790.1 - 4.9 5.9 27.8 0.05 12.5 15.0 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Spt20 PF12090.8 CDI80791.1 - 1.1 8.8 14.7 0.015 15.0 7.7 1.5 2 0 0 2 2 2 0 Spt20 family DUF4551 PF15087.6 CDI80791.1 - 2.3 6.9 7.2 2.6 6.8 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Nucleo_P87 PF07267.11 CDI80791.1 - 2.6 6.8 6.1 3.1 6.5 6.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Aminotran_5 PF00266.19 CDI80792.1 - 6.3e-71 239.3 7.2 1.6e-61 208.3 2.0 2.3 1 1 1 2 2 2 2 Aminotransferase class-V CitMHS PF03600.16 CDI80792.1 - 6.6e-05 22.2 7.5 8.1e-05 22.0 7.5 1.2 1 0 0 1 1 1 1 Citrate transporter Activator_LAG-3 PF11498.8 CDI80792.1 - 0.13 11.2 17.7 0.033 13.2 12.5 2.1 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Roughex PF06020.11 CDI80792.1 - 0.87 8.6 2.8 2.6 7.0 3.2 1.5 2 0 0 2 2 2 0 Drosophila roughex protein Spt20 PF12090.8 CDI80792.1 - 6.1 6.4 14.8 9.9 5.7 14.8 1.2 1 0 0 1 1 1 0 Spt20 family DUF1645 PF07816.11 CDI80793.1 - 0.024 15.3 7.0 0.024 15.3 7.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) CCDC24 PF15669.5 CDI80793.1 - 0.19 11.6 6.6 0.26 11.1 6.1 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Dehydrin PF00257.19 CDI80793.1 - 0.52 10.9 7.2 1.3 9.5 7.2 1.6 1 0 0 1 1 1 0 Dehydrin IHABP4_N PF16174.5 CDI80793.1 - 1.6 9.3 6.0 2.9 8.5 2.6 2.2 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal SR-25 PF10500.9 CDI80793.1 - 1.9 8.1 14.9 0.27 10.8 10.7 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RabGAP-TBC PF00566.18 CDI80794.1 - 6.1e-22 78.3 0.0 1.1e-21 77.5 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_S64 PF08192.11 CDI80794.1 - 2.1 6.8 19.9 3.7 5.9 19.9 1.3 1 0 0 1 1 1 0 Peptidase family S64 Presenilin PF01080.17 CDI80794.1 - 7.9 5.1 13.3 0.11 11.2 2.3 2.0 2 0 0 2 2 2 0 Presenilin DcuA_DcuB PF03605.14 CDI80796.1 - 0.0057 15.6 0.6 0.0057 15.6 0.6 1.9 2 0 0 2 2 2 1 Anaerobic c4-dicarboxylate membrane transporter Presenilin PF01080.17 CDI80796.1 - 0.035 12.9 17.9 0.053 12.3 17.9 1.2 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 CDI80796.1 - 0.043 12.8 42.8 0.02 13.8 14.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Dicty_REP PF05086.12 CDI80796.1 - 0.053 11.5 3.3 0.069 11.1 3.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4770 PF15994.5 CDI80796.1 - 0.12 12.6 20.6 1 9.6 7.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) EIF4E-T PF10477.9 CDI80796.1 - 0.13 11.1 30.3 0.15 10.9 30.3 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF5523 PF17661.1 CDI80796.1 - 0.15 11.7 20.7 0.14 11.9 7.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) TERB2 PF15101.6 CDI80796.1 - 0.24 11.4 26.9 0.31 11.1 11.0 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CPSF100_C PF13299.6 CDI80796.1 - 0.28 11.3 16.6 0.34 11.1 4.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1764 PF08576.10 CDI80796.1 - 0.3 12.0 15.2 2.3 9.1 1.5 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Spt20 PF12090.8 CDI80796.1 - 0.34 10.5 56.9 0.39 10.3 22.0 2.1 2 0 0 2 2 2 0 Spt20 family SpoIIP PF07454.11 CDI80796.1 - 0.38 10.2 21.6 0.55 9.6 8.1 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF3499 PF12005.8 CDI80796.1 - 0.39 11.3 12.4 0.17 12.5 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) Connexin PF00029.19 CDI80796.1 - 0.62 9.8 14.0 0.53 10.0 3.6 2.1 2 0 0 2 2 2 0 Connexin DUF1467 PF07330.12 CDI80796.1 - 0.64 10.0 0.0 0.64 10.0 0.0 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF1467) MDM10 PF12519.8 CDI80796.1 - 0.65 8.8 12.2 0.96 8.2 12.2 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 ATAD4 PF15321.6 CDI80796.1 - 0.71 11.3 13.0 1.6 10.1 2.5 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Eapp_C PF10238.9 CDI80796.1 - 0.92 9.6 19.3 1.9 8.6 2.9 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein Afi1 PF07792.12 CDI80796.1 - 0.99 9.9 17.9 0.91 10.0 6.4 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Exo5 PF09810.9 CDI80796.1 - 1 8.8 13.8 0.72 9.3 4.9 2.0 2 0 0 2 2 2 0 Exonuclease V - a 5' deoxyribonuclease Slu7 PF11708.8 CDI80796.1 - 1.2 8.9 18.6 2.1 8.0 7.8 2.0 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor DUF3408 PF11888.8 CDI80796.1 - 1.2 9.2 22.9 0.096 12.8 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF702 PF05142.12 CDI80796.1 - 1.3 9.5 17.7 3.2 8.2 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF4628 PF15429.6 CDI80796.1 - 1.4 8.6 20.4 0.24 11.0 7.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) DUF4637 PF15470.6 CDI80796.1 - 1.4 8.6 13.1 1.5 8.5 6.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF853 PF05872.12 CDI80796.1 - 1.6 7.2 19.8 0.064 11.8 7.8 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) FAM60A PF15396.6 CDI80796.1 - 1.7 8.6 13.4 1.3 9.0 3.5 2.1 2 0 0 2 2 2 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CDI80796.1 - 1.7 8.4 20.8 1.1 9.1 7.8 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI80796.1 - 1.7 7.3 18.5 1.8 7.3 3.8 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 PRC2_HTH_1 PF18118.1 CDI80796.1 - 1.8 9.4 16.4 2.8 8.8 6.9 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain CLN3 PF02487.17 CDI80796.1 - 1.9 7.4 13.6 0.29 10.1 2.9 2.0 2 0 0 2 2 2 0 CLN3 protein XAP5 PF04921.14 CDI80796.1 - 2.3 8.0 15.4 4.9 6.9 6.7 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator RPA43_OB PF17875.1 CDI80796.1 - 2.3 8.8 13.9 2.7 8.6 3.0 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I FAM176 PF14851.6 CDI80796.1 - 2.4 7.8 14.2 1.5 8.5 5.2 2.1 2 0 0 2 2 2 0 FAM176 family Rtf2 PF04641.12 CDI80796.1 - 2.4 7.5 14.7 5 6.4 7.0 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger PAP_RNA-bind PF04926.15 CDI80796.1 - 3.2 7.4 13.6 1.4 8.5 4.7 2.1 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain RMP PF14996.6 CDI80796.1 - 3.9 7.7 15.6 3.5 7.8 5.1 2.1 2 0 0 2 2 2 0 Retinal Maintenance TRAP_alpha PF03896.16 CDI80796.1 - 4.1 6.5 13.6 1.2 8.3 5.4 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit MecA PF05389.12 CDI80796.1 - 4.1 7.0 18.0 0.38 10.3 3.9 2.1 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Rxt3 PF08642.10 CDI80796.1 - 4.3 8.1 14.9 8.6 7.1 3.9 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 BRF1 PF07741.13 CDI80796.1 - 4.3 7.7 18.7 4.4 7.7 5.7 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Peroxin-13_N PF04088.13 CDI80796.1 - 4.3 7.6 13.2 1.2 9.4 2.5 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region tRNA_synt_1c_R2 PF04557.15 CDI80796.1 - 4.4 8.3 16.2 3.2 8.7 2.8 2.3 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Pdase_M17_N2 PF18295.1 CDI80796.1 - 5 7.4 8.1 0.13 12.5 0.9 2.0 2 1 0 2 2 1 0 M17 aminopeptidase N-terminal domain 2 DUF4484 PF14831.6 CDI80796.1 - 5.7 6.9 14.1 1.4 8.9 4.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) MMR1 PF08505.10 CDI80796.1 - 7 6.9 28.5 0.56 10.5 9.7 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF2370 PF10176.9 CDI80796.1 - 7.2 6.2 10.9 1.9 8.1 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF4578 PF15147.6 CDI80796.1 - 7.4 7.5 25.6 4.1 8.3 8.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) EFTUD2 PF16004.5 CDI80796.1 - 9.2 6.9 23.6 4.9 7.8 4.0 2.1 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Spore_coat_CotO PF14153.6 CDI80796.1 - 9.4 6.1 30.3 2.9 7.8 8.0 2.1 2 0 0 2 2 2 0 Spore coat protein CotO SICA_C PF12879.7 CDI80797.1 - 0.031 14.3 0.5 0.096 12.7 0.2 2.0 1 1 0 1 1 1 0 SICA C-terminal inner membrane domain CRR7 PF12095.8 CDI80797.1 - 0.18 12.3 0.0 0.18 12.3 0.0 4.4 5 0 0 5 5 5 0 Protein CHLORORESPIRATORY REDUCTION 7 RRM_1 PF00076.22 CDI80798.1 - 0.0001 22.1 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_C42 PF05533.12 CDI80798.1 - 0.19 11.8 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 DUF179 PF02622.15 CDI80799.1 - 9e-09 35.5 0.0 2.6e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized ACR, COG1678 DUF5421 PF17458.2 CDI80799.1 - 0.00054 19.5 0.5 0.00054 19.5 0.5 3.9 4 0 0 4 4 4 1 Family of unknown function (DUF5421) FMO-like PF00743.19 CDI80799.1 - 0.018 13.5 0.0 0.028 12.9 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Spt20 PF12090.8 CDI80799.1 - 1.3 8.6 42.9 0.12 11.9 5.9 4.5 4 0 0 4 4 4 0 Spt20 family Sec16 PF12932.7 CDI80799.1 - 4.7 7.8 6.9 11 6.6 0.1 3.8 3 0 0 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region SR-25 PF10500.9 CDI80801.1 - 0.00056 19.6 10.7 0.00056 19.6 10.7 4.2 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Churchill PF06573.11 CDI80801.1 - 0.14 12.4 1.4 0.28 11.5 1.4 1.5 1 0 0 1 1 1 0 Churchill protein UPF0016 PF01169.19 CDI80806.1 - 7.2e-27 93.5 29.0 4.4e-16 59.0 7.3 2.8 3 0 0 3 3 2 2 Uncharacterized protein family UPF0016 SID-1_RNA_chan PF13965.6 CDI80806.1 - 0.0056 15.2 0.1 0.01 14.3 0.1 1.7 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 Otopetrin PF03189.13 CDI80806.1 - 0.0073 15.2 2.2 0.012 14.4 2.2 1.4 1 0 0 1 1 1 1 Otopetrin AAA_11 PF13086.6 CDI80806.1 - 0.035 13.9 19.5 0.058 13.2 19.5 1.3 1 0 0 1 1 1 0 AAA domain Caldesmon PF02029.15 CDI80806.1 - 0.064 12.0 33.5 0.1 11.4 33.5 1.2 1 0 0 1 1 1 0 Caldesmon RR_TM4-6 PF06459.12 CDI80806.1 - 0.15 11.8 31.8 0.3 10.9 31.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 CDI80806.1 - 0.25 10.4 25.7 0.18 10.9 24.0 1.5 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Endostatin PF06482.11 CDI80806.1 - 0.26 10.7 18.2 0.49 9.8 18.2 1.5 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hamartin PF04388.12 CDI80806.1 - 0.31 9.7 22.9 0.55 8.8 22.9 1.3 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CDI80806.1 - 0.42 10.6 48.7 0.053 13.5 44.0 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI80806.1 - 0.95 9.0 23.0 1.5 8.3 23.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Draxin PF15550.6 CDI80806.1 - 1 9.1 23.2 1.9 8.3 23.2 1.3 1 0 0 1 1 1 0 Draxin Neur_chan_memb PF02932.16 CDI80806.1 - 1.2 9.1 21.1 0.51 10.4 18.3 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CDI80806.1 - 1.4 7.1 25.7 2.2 6.5 25.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2784 PF10861.8 CDI80806.1 - 1.4 8.9 6.4 0.15 12.1 0.7 2.2 2 0 0 2 2 2 0 Protein of Unknown function (DUF2784) GAGA_bind PF06217.12 CDI80806.1 - 1.9 8.7 22.8 3.1 8.0 22.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family ALMT PF11744.8 CDI80806.1 - 2.7 6.7 20.0 4.2 6.1 20.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PAT1 PF09770.9 CDI80806.1 - 3 6.0 38.3 4.1 5.6 38.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dicty_REP PF05086.12 CDI80806.1 - 3.1 5.7 13.0 4 5.3 13.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Cellulose_synt PF03552.14 CDI80806.1 - 3.4 6.1 8.4 4.8 5.6 8.4 1.1 1 0 0 1 1 1 0 Cellulose synthase SOG2 PF10428.9 CDI80806.1 - 5.4 6.1 21.1 0.81 8.8 12.7 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein Sec62 PF03839.16 CDI80806.1 - 6 6.3 24.5 13 5.2 24.5 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4746 PF15928.5 CDI80806.1 - 6.3 6.1 23.8 11 5.4 23.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.15 CDI80806.1 - 6.4 5.7 27.8 9.9 5.1 27.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI80806.1 - 7.2 4.6 25.1 13 3.8 25.1 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Lin-8 PF03353.15 CDI80806.1 - 7.3 6.1 31.3 68 2.9 30.1 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 CDI80806.1 - 9.2 3.2 25.8 13 2.7 25.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Raftlin PF15250.6 CDI80806.1 - 9.6 4.8 23.6 18 3.9 23.6 1.4 1 0 0 1 1 1 0 Raftlin GPI2 PF06432.11 CDI80808.1 - 3.3e-28 98.9 3.7 3.6e-28 98.8 3.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase PC_rep PF01851.22 CDI80809.1 - 1.3e-07 31.6 11.4 0.024 15.0 0.1 4.9 4 0 0 4 4 4 3 Proteasome/cyclosome repeat Sporozoite_P67 PF05642.11 CDI80809.1 - 0.003 15.7 6.5 0.094 10.8 0.0 3.4 3 1 0 3 3 3 1 Sporozoite P67 surface antigen Spt20 PF12090.8 CDI80809.1 - 0.13 11.8 8.7 0.25 10.9 8.7 1.4 1 0 0 1 1 1 0 Spt20 family PepX_C PF08530.10 CDI80809.1 - 0.41 10.6 2.9 0.77 9.6 2.9 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain RNA_pol_Rpc4 PF05132.14 CDI80809.1 - 0.49 10.8 3.6 0.69 10.3 0.3 2.7 3 0 0 3 3 3 0 RNA polymerase III RPC4 Methyltransf_32 PF13679.6 CDI80811.1 - 0.098 12.6 0.6 0.25 11.3 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain TFIIA PF03153.13 CDI80811.1 - 0.39 10.7 15.4 0.55 10.2 15.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IHABP4_N PF16174.5 CDI80811.1 - 5.5 7.6 10.6 1.9 9.1 4.4 2.1 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal MIF4G_like_2 PF09090.11 CDI80812.1 - 8.3e-11 41.9 1.1 3.3e-10 39.9 0.1 2.4 3 0 0 3 3 3 1 MIF4G like MIF4G PF02854.19 CDI80812.1 - 1.6e-06 27.9 0.8 3.7e-06 26.7 0.1 1.9 2 0 0 2 2 2 1 MIF4G domain DUF4255 PF14065.6 CDI80812.1 - 0.023 14.4 0.5 0.049 13.3 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4255) Presenilin PF01080.17 CDI80813.1 - 1.3 7.7 40.5 1.4 7.6 40.5 1.1 1 0 0 1 1 1 0 Presenilin MecA PF05389.12 CDI80815.1 - 0.029 14.0 0.4 0.029 14.0 0.4 3.0 2 1 1 3 3 3 0 Negative regulator of genetic competence (MecA) Ribosomal_60s PF00428.19 CDI80815.1 - 0.032 14.8 2.9 0.032 14.8 2.9 6.1 3 1 2 6 6 5 0 60s Acidic ribosomal protein CD20 PF04103.15 CDI80815.1 - 0.17 11.9 4.6 0.52 10.4 0.0 3.5 4 0 0 4 4 4 0 CD20-like family Presenilin PF01080.17 CDI80815.1 - 0.41 9.3 36.0 0.23 10.2 11.2 3.1 3 0 0 3 3 3 0 Presenilin bMG10 PF17973.1 CDI80815.1 - 0.57 10.4 5.1 0.99 9.6 0.8 3.1 3 0 0 3 3 3 0 Bacterial Alpha-2-macroglobulin MG10 domain FHIPEP PF00771.20 CDI80815.1 - 0.9 7.9 9.4 0.031 12.8 1.6 2.1 2 0 0 2 2 2 0 FHIPEP family DcuA_DcuB PF03605.14 CDI80815.1 - 1.8 7.4 3.6 1.1 8.1 0.1 2.0 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Pinin_SDK_memA PF04696.13 CDI80815.1 - 2.6 8.1 33.0 1.7 8.7 20.2 2.7 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region SLC12 PF03522.15 CDI80815.1 - 3.2 6.7 27.4 0.79 8.7 10.0 2.4 2 0 0 2 2 2 0 Solute carrier family 12 Spt5_N PF11942.8 CDI80815.1 - 3.7 8.6 32.0 1.7 9.7 0.2 4.2 4 0 0 4 4 4 0 Spt5 transcription elongation factor, acidic N-terminal OSTbeta PF15048.6 CDI80815.1 - 5.3 7.2 10.7 0.3 11.2 3.2 2.5 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Folate_carrier PF01770.18 CDI80815.1 - 9.6 4.8 10.0 0.36 9.5 1.6 2.2 2 0 0 2 2 2 0 Reduced folate carrier Spt20 PF12090.8 CDI80816.1 - 0.0017 18.0 26.0 0.022 14.4 9.8 2.3 2 0 0 2 2 2 2 Spt20 family DUF5421 PF17458.2 CDI80816.1 - 0.0025 17.3 11.1 0.011 15.2 0.1 2.4 2 0 0 2 2 2 2 Family of unknown function (DUF5421) SUIM_assoc PF16619.5 CDI80816.1 - 0.013 15.5 5.6 0.013 15.5 5.6 3.7 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF3043 PF11241.8 CDI80817.1 - 0.15 12.1 0.5 0.19 11.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) SUIM_assoc PF16619.5 CDI80819.1 - 0.0081 16.2 2.9 0.0081 16.2 2.9 9.8 4 2 3 7 7 7 2 Unstructured region C-term to UIM in Ataxin3 CHORD PF04968.12 CDI80820.1 - 2e-08 34.8 0.9 2e-08 34.8 0.9 2.6 3 0 0 3 3 3 1 CHORD TMEM154 PF15102.6 CDI80821.1 - 0.0016 18.4 3.8 0.0016 18.4 3.8 1.8 1 1 0 2 2 2 1 TMEM154 protein family DUF2339 PF10101.9 CDI80821.1 - 0.0089 14.7 6.1 0.013 14.1 6.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) AP3B1_C PF14796.6 CDI80821.1 - 0.32 11.2 2.8 0.21 11.9 1.1 1.6 2 0 0 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal DUF3488 PF11992.8 CDI80821.1 - 4 6.3 9.4 0.11 11.4 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) 2-oxoacid_dh PF00198.23 CDI80822.1 - 2.6e-15 56.5 0.6 4.1e-15 55.9 0.6 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Spt20 PF12090.8 CDI80822.1 - 0.013 15.1 8.7 0.013 15.1 8.7 1.9 2 0 0 2 2 2 0 Spt20 family AF-4 PF05110.13 CDI80822.1 - 0.017 13.2 16.0 0.017 13.3 9.8 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF4834 PF16118.5 CDI80822.1 - 4.6 8.3 8.4 5.8 7.9 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PrsW-protease PF13367.6 CDI80824.1 - 0.046 13.2 0.9 0.15 11.5 0.5 2.1 2 0 0 2 2 2 0 PrsW family intramembrane metalloprotease MBR1 PF17058.5 CDI80824.1 - 0.22 11.8 7.0 0.44 10.8 6.6 1.6 1 1 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 DUF3995 PF13160.6 CDI80824.1 - 5.7 7.3 20.6 2.9 8.3 2.2 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3995) Nop PF01798.18 CDI80827.1 - 3e-70 236.3 0.9 1.9e-56 191.1 0.5 2.2 1 1 1 2 2 2 2 snoRNA binding domain, fibrillarin DUF3138 PF11336.8 CDI80827.1 - 0.85 8.2 4.9 1.2 7.6 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TPR_2 PF07719.17 CDI80828.1 - 0.0045 17.0 10.2 2.3 8.5 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI80828.1 - 0.0057 16.8 18.4 0.026 14.7 2.4 4.6 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI80828.1 - 0.069 13.2 3.0 0.15 12.1 1.2 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat DUF2877 PF11392.8 CDI80828.1 - 0.13 13.0 1.6 1.9 9.2 0.3 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2877) DUF4574 PF15141.6 CDI80828.1 - 1.1 9.3 4.2 14 5.7 0.7 2.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Arm PF00514.23 CDI80828.1 - 1.1 9.4 19.3 15 5.8 0.8 6.8 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat TFIIA PF03153.13 CDI80828.1 - 3.1 7.7 29.6 0.069 13.1 9.8 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-CCCH_4 PF18044.1 CDI80829.1 - 0.0027 17.5 0.7 0.0027 17.5 0.7 3.6 4 1 0 4 4 4 1 CCCH-type zinc finger zf-CCCH PF00642.24 CDI80829.1 - 0.003 17.4 0.8 0.003 17.4 0.8 3.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SUIM_assoc PF16619.5 CDI80829.1 - 0.0087 16.1 0.1 0.0087 16.1 0.1 16.6 7 4 3 11 11 11 4 Unstructured region C-term to UIM in Ataxin3 SBDS_C PF09377.10 CDI80831.1 - 1.5 8.9 3.9 0.81 9.7 1.9 1.6 2 0 0 2 2 2 0 SBDS protein C-terminal domain CorA PF01544.18 CDI80831.1 - 1.6 7.9 9.8 0.33 10.2 6.1 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.15 CDI80831.1 - 3.4 7.2 17.5 5.5 6.5 17.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sas6_CC PF18594.1 CDI80831.1 - 4.5 7.1 11.5 0.4 10.5 2.4 2.8 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain DOR PF14839.6 CDI80831.1 - 5.9 6.8 14.7 6.8 6.6 13.9 1.5 1 1 0 1 1 1 0 DOR family DUF4407 PF14362.6 CDI80831.1 - 7.8 5.7 22.3 11 5.2 22.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PP2C_C PF07830.13 CDI80831.1 - 9.2 6.8 9.0 1.4 9.5 1.3 2.3 1 1 1 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain GCP_C_terminal PF04130.13 CDI80832.1 - 8.3e-18 64.9 0.0 1.6e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Macoilin PF09726.9 CDI80834.1 - 0.023 13.3 19.2 0.031 12.9 19.2 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI80834.1 - 0.037 14.0 25.9 0.045 13.7 25.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Band_3_cyto PF07565.13 CDI80834.1 - 0.52 10.1 16.0 0.65 9.8 16.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Sporozoite_P67 PF05642.11 CDI80834.1 - 0.54 8.3 12.0 0.58 8.2 12.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MMU163 PF17119.5 CDI80834.1 - 1.1 8.4 9.2 1.6 7.8 9.2 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF2052 PF09747.9 CDI80834.1 - 1.7 8.7 10.8 2.2 8.3 10.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Apt1 PF10351.9 CDI80834.1 - 1.9 7.3 17.9 2.4 6.9 17.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAP1 PF08601.10 CDI80834.1 - 3.1 7.4 22.1 3.7 7.2 22.1 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Miga PF10265.9 CDI80834.1 - 3.3 6.6 15.2 3.8 6.4 15.2 1.1 1 0 0 1 1 1 0 Mitoguardin PARM PF17061.5 CDI80834.1 - 3.7 7.6 21.2 4.5 7.3 21.2 1.1 1 0 0 1 1 1 0 PARM CCDC24 PF15669.5 CDI80834.1 - 5.1 6.9 16.4 4.8 7.0 15.6 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Mem_trans PF03547.18 CDI80834.1 - 8.3 4.7 7.8 12 4.1 7.8 1.2 1 0 0 1 1 1 0 Membrane transport protein DUF572 PF04502.13 CDI80835.1 - 0.00021 21.0 5.5 0.00026 20.7 5.5 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) CDC45 PF02724.14 CDI80835.1 - 0.0053 15.1 6.8 0.0075 14.6 6.8 1.2 1 0 0 1 1 1 1 CDC45-like protein SUIM_assoc PF16619.5 CDI80835.1 - 0.013 15.6 10.2 0.013 15.6 10.2 4.3 3 2 0 3 3 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI80835.1 - 0.019 14.6 10.5 0.019 14.6 10.5 3.0 2 1 1 3 3 2 0 Spt20 family Apt1 PF10351.9 CDI80835.1 - 0.022 13.6 4.7 0.029 13.2 4.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hid1 PF12722.7 CDI80835.1 - 0.028 12.6 9.1 0.035 12.3 9.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AUX_IAA PF02309.16 CDI80835.1 - 0.052 13.4 11.0 0.076 12.9 11.0 1.2 1 0 0 1 1 1 0 AUX/IAA family SAPS PF04499.15 CDI80835.1 - 0.17 10.6 7.7 0.22 10.3 7.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Fumble PF03630.14 CDI80835.1 - 0.2 10.8 2.8 0.32 10.1 2.8 1.4 1 0 0 1 1 1 0 Fumble Gti1_Pac2 PF09729.9 CDI80835.1 - 0.26 11.3 10.7 1.8 8.6 4.7 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Rtf2 PF04641.12 CDI80835.1 - 0.26 10.6 10.5 3.5 6.9 7.1 2.0 2 0 0 2 2 2 0 Rtf2 RING-finger SpoIIP PF07454.11 CDI80835.1 - 0.27 10.6 15.1 0.4 10.1 5.4 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Ndc1_Nup PF09531.10 CDI80835.1 - 0.3 9.7 10.9 0.4 9.3 10.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Afi1 PF07792.12 CDI80835.1 - 0.49 10.9 12.4 1.3 9.6 3.3 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Baculo_PP31 PF05311.11 CDI80835.1 - 0.61 9.5 15.3 0.13 11.7 4.2 2.0 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) CPSF100_C PF13299.6 CDI80835.1 - 0.79 9.9 11.3 4.3 7.5 5.1 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ASD2 PF08687.11 CDI80835.1 - 0.93 9.0 17.9 1.1 8.8 8.2 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 DUF908 PF06012.12 CDI80835.1 - 1.1 8.6 13.0 0.57 9.6 5.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Folliculin PF11704.8 CDI80835.1 - 1.7 8.5 11.7 9.5 6.1 0.2 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport RR_TM4-6 PF06459.12 CDI80835.1 - 1.7 8.4 17.4 1 9.1 8.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 cwf18 PF08315.12 CDI80835.1 - 1.9 9.1 14.5 6.4 7.4 6.2 2.1 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor DUF2052 PF09747.9 CDI80835.1 - 4.4 7.4 18.8 6.3 6.9 0.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Band_3_cyto PF07565.13 CDI80835.1 - 6.9 6.4 14.6 6 6.6 6.0 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4175 PF13779.6 CDI80835.1 - 7.8 4.3 45.0 3.7 5.3 7.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) IER PF05760.12 CDI80835.1 - 8.1 6.6 23.4 5.4 7.2 4.3 2.1 2 0 0 2 2 2 0 Immediate early response protein (IER) DUF1180 PF06679.12 CDI80835.1 - 9.6 6.6 7.5 5.2 7.5 4.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Med3 PF11593.8 CDI80836.1 - 0.019 14.2 62.8 0.022 14.0 20.4 3.5 3 0 0 3 3 3 0 Mediator complex subunit 3 fungal Hamartin PF04388.12 CDI80836.1 - 4 6.0 36.1 0.51 8.9 11.5 2.2 2 0 0 2 2 2 0 Hamartin protein DUF5304 PF17230.2 CDI80839.1 - 0.022 15.0 3.6 0.031 14.5 3.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5304) FAM167 PF11652.8 CDI80839.1 - 1.6 9.3 4.8 1.2 9.6 0.3 2.7 3 1 1 4 4 4 0 FAM167 Ephrin_rec_like PF07699.13 CDI80840.1 - 0.0017 18.1 8.3 0.0017 18.1 8.3 4.2 2 1 2 4 4 4 2 Putative ephrin-receptor like TNFR_c6 PF00020.18 CDI80840.1 - 0.26 11.7 21.8 0.38 11.2 4.5 3.8 2 2 0 3 3 3 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 CDI80841.1 - 1.2e-05 25.0 44.7 0.013 15.2 4.0 6.6 4 1 2 6 6 6 4 Putative ephrin-receptor like F5_F8_type_C PF00754.25 CDI80841.1 - 0.0021 18.2 0.0 0.0035 17.5 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain SKA1 PF07160.12 CDI80843.1 - 0.016 15.0 6.5 0.017 15.0 6.5 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4407 PF14362.6 CDI80843.1 - 0.041 13.3 12.6 0.053 12.9 12.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALS2CR8 PF15299.6 CDI80843.1 - 0.051 13.5 3.7 0.067 13.1 3.7 1.2 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Exonuc_VII_L PF02601.15 CDI80843.1 - 0.066 12.8 11.2 0.067 12.8 11.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit COG6 PF06419.11 CDI80843.1 - 0.099 10.8 12.7 0.12 10.5 12.7 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Allexi_40kDa PF05549.11 CDI80843.1 - 0.12 11.9 3.9 0.14 11.7 3.9 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein Atg14 PF10186.9 CDI80843.1 - 0.12 11.4 9.2 0.14 11.2 9.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF16 PF01519.16 CDI80843.1 - 0.14 12.7 13.7 0.21 12.1 13.7 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 AAA_13 PF13166.6 CDI80843.1 - 0.18 10.4 4.2 0.17 10.5 4.2 1.1 1 0 0 1 1 1 0 AAA domain Muted PF14942.6 CDI80843.1 - 0.2 12.0 10.7 0.28 11.5 10.7 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DASH_Spc34 PF08657.10 CDI80843.1 - 0.22 11.3 8.9 0.27 11.0 8.9 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Golgin_A5 PF09787.9 CDI80843.1 - 0.26 10.7 16.1 0.33 10.4 16.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 FHIPEP PF00771.20 CDI80843.1 - 0.41 9.1 4.7 0.46 8.9 4.7 1.1 1 0 0 1 1 1 0 FHIPEP family V_ATPase_I PF01496.19 CDI80843.1 - 0.46 8.3 5.0 0.41 8.5 5.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nup88 PF10168.9 CDI80843.1 - 0.66 7.7 12.6 0.8 7.4 12.6 1.1 1 0 0 1 1 1 0 Nuclear pore component Spc7 PF08317.11 CDI80843.1 - 0.71 8.7 16.5 0.83 8.5 15.6 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein LMBR1 PF04791.16 CDI80843.1 - 0.72 8.7 2.9 0.66 8.8 2.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIA PF03153.13 CDI80843.1 - 0.72 9.8 14.9 0.76 9.7 14.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF948 PF06103.11 CDI80843.1 - 0.73 10.1 4.4 1.2 9.5 4.4 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FUSC PF04632.12 CDI80843.1 - 0.83 8.1 11.6 0.88 8.0 11.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family IL2 PF00715.17 CDI80843.1 - 1 9.3 6.6 1.3 9.0 5.6 1.5 1 1 0 1 1 1 0 Interleukin 2 HemX PF04375.14 CDI80843.1 - 1.1 8.5 20.2 1.4 8.2 20.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase IFT57 PF10498.9 CDI80843.1 - 1.1 8.2 13.0 1.4 7.8 13.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 T3SSipB PF16535.5 CDI80843.1 - 1.1 9.7 18.3 1.5 9.3 18.3 1.3 1 1 0 1 1 1 0 Type III cell invasion protein SipB L31 PF09784.9 CDI80843.1 - 1.2 9.6 8.1 2.2 8.7 8.1 1.4 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L31 Noelin-1 PF12308.8 CDI80843.1 - 1.6 8.7 11.1 2.7 8.0 11.1 1.4 1 0 0 1 1 1 0 Neurogenesis glycoprotein ADIP PF11559.8 CDI80843.1 - 1.7 8.7 18.5 2.5 8.2 18.5 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FPP PF05911.11 CDI80843.1 - 1.8 6.7 13.9 2.1 6.4 13.9 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil kleA_kleC PF17383.2 CDI80843.1 - 2.4 8.5 8.3 11 6.4 0.1 2.7 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A MctB PF11382.8 CDI80843.1 - 3.8 7.1 8.8 5.8 6.5 8.8 1.3 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB MCU PF04678.13 CDI80843.1 - 4.3 7.4 7.9 6.5 6.8 7.9 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TMPIT PF07851.13 CDI80843.1 - 4.7 6.4 8.5 5.5 6.1 8.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 CDI80843.1 - 4.7 7.9 11.9 5.6 7.7 10.0 2.0 1 1 1 2 2 2 0 Initiation control protein YabA FlxA PF14282.6 CDI80843.1 - 4.8 7.2 28.6 7.7 6.6 28.6 1.4 1 0 0 1 1 1 0 FlxA-like protein Uso1_p115_C PF04871.13 CDI80843.1 - 5.7 7.3 15.3 0.86 10.0 11.3 1.7 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Macoilin PF09726.9 CDI80843.1 - 6 5.3 11.2 5.6 5.4 11.2 1.1 1 0 0 1 1 1 0 Macoilin family GrpE PF01025.19 CDI80843.1 - 7.7 6.2 11.3 5.8 6.6 10.0 1.6 1 1 0 1 1 1 0 GrpE MAP65_ASE1 PF03999.12 CDI80844.1 - 9.5 4.8 17.1 10 4.7 17.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) KBP_C PF12309.8 CDI80845.1 - 0.0017 18.0 1.7 0.002 17.8 1.7 1.3 1 0 0 1 1 1 1 KIF-1 binding protein C terminal Presenilin PF01080.17 CDI80845.1 - 0.012 14.4 3.9 0.017 13.9 3.9 1.2 1 0 0 1 1 1 0 Presenilin GDPD PF03009.17 CDI80845.1 - 0.03 14.1 0.3 0.042 13.6 0.3 1.1 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family NPR3 PF03666.13 CDI80845.1 - 0.065 12.0 5.0 0.073 11.9 5.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Med3 PF11593.8 CDI80845.1 - 0.066 12.4 15.6 0.019 14.2 7.0 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Ndc1_Nup PF09531.10 CDI80845.1 - 0.21 10.2 5.7 0.23 10.1 5.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PI3K_1B_p101 PF10486.9 CDI80845.1 - 0.31 8.8 10.1 0.36 8.6 10.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Zip PF02535.22 CDI80845.1 - 0.35 10.0 2.6 0.36 10.0 2.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_S64 PF08192.11 CDI80845.1 - 0.62 8.5 8.9 5.7 5.3 8.0 2.0 2 0 0 2 2 2 0 Peptidase family S64 Band_3_cyto PF07565.13 CDI80845.1 - 0.97 9.2 5.5 1.5 8.6 5.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Pal1 PF08316.11 CDI80845.1 - 1.3 9.8 4.2 14 6.4 4.2 2.2 1 1 0 1 1 1 0 Pal1 cell morphology protein MAJIN PF15077.6 CDI80845.1 - 1.7 8.4 6.6 2.6 7.8 6.6 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF4614 PF15391.6 CDI80845.1 - 3.5 7.6 17.4 5.6 6.9 17.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CCDC106 PF15794.5 CDI80845.1 - 6.8 6.3 13.1 12 5.6 13.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 His_Phos_1 PF00300.22 CDI80846.1 - 2.9e-08 33.6 0.1 2.9e-08 33.6 0.1 3.1 2 1 1 3 3 3 1 Histidine phosphatase superfamily (branch 1) RskA PF10099.9 CDI80846.1 - 0.016 15.5 16.5 0.016 15.5 16.5 3.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA CCSAP PF15748.5 CDI80846.1 - 0.32 11.1 20.0 0.039 14.1 15.7 1.7 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Phage_holin_3_6 PF07332.11 CDI80846.1 - 0.78 9.8 21.2 0.94 9.5 15.9 2.8 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Suf PF05843.14 CDI80846.1 - 5.1 7.0 19.2 0.42 10.6 14.7 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Cyt_bd_oxida_II PF02322.15 CDI80846.1 - 9.4 5.5 11.2 1.7 7.9 7.7 1.4 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II Pkinase PF00069.25 CDI80847.1 - 4.2e-41 141.0 0.0 4.2e-41 141.0 0.0 4.4 3 2 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80847.1 - 6.5e-19 68.2 0.0 6.5e-19 68.2 0.0 3.4 4 1 0 4 4 4 1 Protein tyrosine kinase zf-CCCH PF00642.24 CDI80848.1 - 8.8e-09 35.1 29.9 0.00013 21.7 5.3 3.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CDI80848.1 - 4.6e-05 24.1 2.0 4.6e-05 24.1 2.0 4.6 2 1 2 4 4 4 3 Torus domain zf_CCCH_4 PF18345.1 CDI80848.1 - 0.0004 20.3 29.0 0.0019 18.2 7.9 4.1 3 1 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 CDI80848.1 - 0.001 18.8 5.8 0.001 18.8 5.8 3.7 4 0 0 4 4 4 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CDI80848.1 - 0.0073 16.5 10.1 0.017 15.4 4.3 2.7 1 1 1 2 2 2 1 Zinc-finger containing family zf-C3H1 PF10650.9 CDI80848.1 - 0.063 13.0 3.9 0.82 9.5 0.6 2.7 2 0 0 2 2 2 0 Putative zinc-finger domain TFIIA PF03153.13 CDI80848.1 - 0.21 11.6 39.9 0.11 12.5 9.8 3.1 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit NAGidase PF07555.13 CDI80850.1 - 0.078 12.3 0.0 0.089 12.1 0.0 1.0 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase DUF2722 PF10846.8 CDI80852.1 - 0.0001 21.4 8.1 0.0001 21.4 8.1 4.4 3 1 0 3 3 3 1 Protein of unknown function (DUF2722) Phage_Mu_F PF04233.14 CDI80852.1 - 0.018 15.7 1.0 0.018 15.7 1.0 3.9 4 1 1 5 5 5 0 Phage Mu protein F like protein Tim54 PF11711.8 CDI80852.1 - 1.3 7.8 27.1 2 7.1 4.3 2.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MDM31_MDM32 PF08118.11 CDI80852.1 - 1.7 7.2 25.7 0.037 12.7 4.2 2.4 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins Archease PF01951.16 CDI80852.1 - 2 8.7 5.8 0.19 12.0 0.1 2.2 2 0 0 2 2 2 0 Archease protein family (MTH1598/TM1083) Glyco_hyd_65N_2 PF14498.6 CDI80852.1 - 3.6 7.4 14.2 7.9 6.2 5.2 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, N-terminal domain CPSF100_C PF13299.6 CDI80852.1 - 9.1 6.4 28.1 0.65 10.2 3.4 3.0 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal MMR_HSR1_Xtn PF16897.5 CDI80853.1 - 1.4e-41 140.8 0.2 2.5e-41 140.0 0.2 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CDI80853.1 - 2e-23 82.2 0.0 3.4e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 TGS domain NPR3 PF03666.13 CDI80854.1 - 0.00042 19.2 3.4 0.00042 19.2 3.4 4.4 4 1 1 5 5 5 2 Nitrogen Permease regulator of amino acid transport activity 3 Pkinase PF00069.25 CDI80856.1 - 6.4e-10 38.8 4.9 2.9e-08 33.4 0.0 4.5 5 1 0 5 5 5 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80856.1 - 0.019 14.2 0.0 0.42 9.8 0.0 2.5 2 0 0 2 2 2 0 Protein tyrosine kinase CCDC53 PF10152.9 CDI80856.1 - 0.026 14.9 1.3 0.026 14.9 1.3 5.7 5 1 0 5 5 5 0 Subunit CCDC53 of WASH complex Velvet PF11754.8 CDI80856.1 - 0.04 13.9 0.1 0.04 13.9 0.1 3.9 2 1 1 3 3 3 0 Velvet factor TFIIA PF03153.13 CDI80863.1 - 1.4 8.8 13.0 1.8 8.4 13.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CDI80863.1 - 6.8 3.7 15.4 7.4 3.5 15.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Telomerase_RBD PF12009.8 CDI80864.1 - 3.3e-23 82.3 17.1 3.3e-23 82.3 17.1 6.1 5 3 0 5 5 5 1 Telomerase ribonucleoprotein complex - RNA binding domain Arnt_C PF18583.1 CDI80865.1 - 0.089 12.4 0.1 0.19 11.4 0.1 1.6 1 1 0 1 1 1 0 Aminoarabinose transferase C-terminal domain CLZ PF16526.5 CDI80865.1 - 0.47 10.9 3.1 1.3 9.4 0.1 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Vps39_2 PF10367.9 CDI80870.1 - 3.6e-18 66.0 0.0 3.6e-18 66.0 0.0 3.8 4 1 1 5 5 5 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 CDI80870.1 - 1.9e-05 24.6 0.5 1.9e-05 24.6 0.5 3.0 3 0 0 3 3 3 1 Region in Clathrin and VPS Spt20 PF12090.8 CDI80870.1 - 0.0096 15.6 14.0 0.0096 15.6 14.0 3.7 3 1 1 4 4 4 1 Spt20 family Suf PF05843.14 CDI80870.1 - 0.046 13.7 20.1 0.24 11.3 9.3 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) EIF4E-T PF10477.9 CDI80870.1 - 8 5.1 22.2 5.8 5.6 11.2 2.4 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DEAD_2 PF06733.15 CDI80871.1 - 5.3e-26 91.3 5.5 4.4e-21 75.3 0.3 3.7 2 1 0 2 2 2 2 DEAD_2 ResIII PF04851.15 CDI80871.1 - 4.6e-05 23.5 9.2 0.00047 20.2 2.3 3.0 3 1 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_25 PF13481.6 CDI80871.1 - 0.0081 15.7 0.9 0.02 14.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 CDI80871.1 - 0.009 15.8 6.3 0.009 15.8 6.3 3.4 3 1 1 4 4 4 1 DEAD/DEAH box helicase Ras PF00071.22 CDI80873.1 - 8.3e-40 136.0 0.6 3.9e-38 130.6 0.3 2.6 2 1 0 2 2 2 1 Ras family Roc PF08477.13 CDI80873.1 - 4.3e-32 110.8 0.0 4.3e-32 110.8 0.0 2.5 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI80873.1 - 3.4e-11 42.9 0.0 5.6e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDI80873.1 - 2e-05 24.0 0.1 2e-05 24.0 0.1 3.0 2 1 0 2 2 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDI80873.1 - 0.00017 21.6 0.6 0.00059 19.8 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CDI80873.1 - 0.00098 19.2 0.0 0.0026 17.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase SpoIIP PF07454.11 CDI80873.1 - 0.016 14.6 0.6 0.016 14.6 0.6 3.0 2 1 1 3 3 2 0 Stage II sporulation protein P (SpoIIP) DUF3881 PF12997.7 CDI80873.1 - 0.021 14.1 0.1 0.021 14.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) IstB_IS21 PF01695.17 CDI80873.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 CDI80873.1 - 0.077 12.7 0.0 0.077 12.7 0.0 2.2 2 0 0 2 2 1 0 AAA domain Hpr_kinase_C PF07475.12 CDI80873.1 - 0.14 11.7 0.0 0.34 10.4 0.0 1.7 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Med15 PF09606.10 CDI80873.1 - 1.5 7.4 36.0 0.17 10.5 3.3 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4175 PF13779.6 CDI80873.1 - 1.8 6.4 27.6 0.055 11.4 14.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) TFIIA PF03153.13 CDI80873.1 - 2.8 7.9 45.6 0.34 10.9 9.0 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PepSY_TM PF03929.16 CDI80873.1 - 3.5 7.2 6.8 4 7.0 1.4 2.1 2 0 0 2 2 2 0 PepSY-associated TM region RAP1 PF07218.11 CDI80873.1 - 7.1 4.8 22.6 11 4.1 22.6 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Presenilin PF01080.17 CDI80874.1 - 0.0015 17.4 2.4 0.0015 17.4 2.4 2.3 2 0 0 2 2 2 1 Presenilin TFIIA PF03153.13 CDI80874.1 - 0.017 15.2 68.8 0.017 15.1 13.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EOS1 PF12326.8 CDI80874.1 - 0.05 13.5 5.2 0.32 10.9 0.3 2.3 2 0 0 2 2 2 0 N-glycosylation protein Exonuc_VII_L PF02601.15 CDI80874.1 - 0.86 9.1 30.1 1.1 8.8 17.4 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit SET PF00856.28 CDI80874.1 - 3.1 8.2 5.1 12 6.3 0.1 2.3 2 0 0 2 2 2 0 SET domain Memo PF01875.17 CDI80875.1 - 2.8e-50 171.0 0.0 4.9e-50 170.2 0.0 1.3 1 1 0 1 1 1 1 Memo-like protein MAJIN PF15077.6 CDI80876.1 - 0.015 15.1 0.3 0.015 15.1 0.3 2.4 2 0 0 2 2 2 0 Membrane-anchored junction protein SasG_E PF17041.5 CDI80876.1 - 0.13 12.2 0.2 0.26 11.3 0.2 1.4 1 0 0 1 1 1 0 E domain FAM220 PF15487.6 CDI80876.1 - 1.4 8.5 10.0 0.92 9.1 0.6 2.4 2 0 0 2 2 2 0 FAM220 family DUF3429 PF11911.8 CDI80878.1 - 1.1e-06 29.0 3.8 1.9e-06 28.2 3.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Presenilin PF01080.17 CDI80878.1 - 0.00076 18.4 0.0 0.0011 17.9 0.0 1.4 1 0 0 1 1 1 1 Presenilin Spt20 PF12090.8 CDI80878.1 - 0.0054 16.4 21.8 0.0054 16.4 21.8 1.6 2 0 0 2 2 2 1 Spt20 family EPL1 PF10513.9 CDI80878.1 - 0.013 15.9 1.4 0.022 15.2 1.4 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like TFIIA PF03153.13 CDI80878.1 - 0.014 15.4 16.3 0.02 14.9 16.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2126 PF09899.9 CDI80878.1 - 0.03 12.4 0.5 0.039 12.0 0.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Plasmodium_Vir PF05795.11 CDI80878.1 - 0.035 13.5 3.9 0.046 13.1 3.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Activator_LAG-3 PF11498.8 CDI80878.1 - 0.06 12.3 17.1 0.091 11.7 17.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 ALMT PF11744.8 CDI80878.1 - 0.12 11.2 1.4 0.16 10.8 1.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4175 PF13779.6 CDI80878.1 - 0.49 8.2 10.7 0.7 7.7 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Orf78 PF06024.12 CDI80878.1 - 0.57 10.5 3.0 22 5.4 3.3 2.3 2 0 0 2 2 2 0 Orf78 (ac78) EIIBC-GUT_N PF03612.14 CDI80878.1 - 1 9.1 4.3 1.7 8.4 4.3 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5421 PF17458.2 CDI80878.1 - 1.1 8.6 9.2 1.7 8.0 9.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5421) Cwf_Cwc_15 PF04889.12 CDI80878.1 - 1.7 8.3 9.7 2.8 7.6 9.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SLC12 PF03522.15 CDI80878.1 - 3.8 6.4 8.2 1.3 8.0 5.5 1.5 2 0 0 2 2 2 0 Solute carrier family 12 Metallophos PF00149.28 CDI80879.1 - 0.00077 20.0 0.0 0.0022 18.5 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase cwf18 PF08315.12 CDI80879.1 - 0.023 15.4 6.1 0.023 15.4 6.1 5.0 5 1 0 5 5 5 0 cwf18 pre-mRNA splicing factor BORG_CEP PF14957.6 CDI80879.1 - 4.7 8.4 17.4 27 6.0 1.2 4.2 4 0 0 4 4 4 0 Cdc42 effector zf-CCCH PF00642.24 CDI80880.1 - 3.3e-11 42.8 22.8 0.00016 21.5 1.9 3.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Sin_N PF04801.13 CDI80880.1 - 0.00027 20.3 9.3 0.00027 20.3 9.3 4.3 2 2 0 4 4 4 1 Sin-like protein conserved region zf_CCCH_4 PF18345.1 CDI80880.1 - 0.00087 19.3 23.0 0.053 13.6 2.2 3.4 3 0 0 3 3 3 3 Zinc finger domain DUF1635 PF07795.11 CDI80880.1 - 0.0054 16.6 5.1 0.0054 16.6 5.1 7.9 7 1 1 8 8 8 2 Protein of unknown function (DUF1635) Torus PF16131.5 CDI80880.1 - 0.0066 17.1 0.2 0.0066 17.1 0.2 7.6 7 1 1 8 8 8 1 Torus domain zf-CCCH_2 PF14608.6 CDI80880.1 - 0.048 14.1 21.9 2.1 8.9 0.7 3.4 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDI80880.1 - 0.31 10.9 19.4 3.6 7.5 4.4 3.7 3 0 0 3 3 3 0 CCCH-type zinc finger Pkinase PF00069.25 CDI80881.1 - 1.3e-20 73.9 0.0 3.4e-20 72.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI80881.1 - 3.5e-14 52.8 0.0 2.4e-13 50.0 0.0 2.0 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI80881.1 - 7.3e-09 35.3 0.0 2e-08 33.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI80881.1 - 0.14 11.5 0.0 0.41 10.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family GcpE PF04551.14 CDI80882.1 - 1.9e-50 171.9 21.5 2e-49 168.6 21.5 3.1 1 1 0 1 1 1 1 GcpE protein Galactosyl_T PF01762.21 CDI80883.1 - 2e-48 164.8 0.0 2.4e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Bestrophin PF01062.21 CDI80883.1 - 0.1 12.0 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Fringe PF02434.16 CDI80883.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Galactosyl_T PF01762.21 CDI80884.1 - 1.2e-43 149.2 0.0 1.5e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 CDI80884.1 - 2.1e-05 24.1 0.0 2.6e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Fringe-like E3_binding PF02817.17 CDI80885.1 - 0.1 13.0 0.0 0.36 11.2 0.0 1.9 2 0 0 2 2 2 0 e3 binding domain RNA_POL_M_15KD PF02150.16 CDI80885.1 - 3.2 7.7 8.7 7.4 6.5 0.2 3.4 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit Calc_CGRP_IAPP PF00214.19 CDI80886.1 - 0.25 11.7 0.1 0.25 11.7 0.1 2.9 2 1 1 3 3 3 0 Calcitonin / CGRP / IAPP family PAN_4 PF14295.6 CDI80887.1 - 0.27 11.2 3.3 0.1 12.5 0.4 1.8 2 0 0 2 2 2 0 PAN domain DEAD PF00270.29 CDI80888.1 - 1.5e-43 148.6 0.0 5.9e-43 146.7 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI80888.1 - 1.7e-30 105.6 0.0 9.5e-30 103.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI80888.1 - 3.9e-06 27.0 0.1 6.1e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 CDI80888.1 - 0.001 18.4 0.0 0.0022 17.3 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain zf-CCHC PF00098.23 CDI80888.1 - 4.7 7.5 8.6 0.36 11.0 3.6 1.8 2 0 0 2 2 2 0 Zinc knuckle IRK_C PF17655.1 CDI80890.1 - 3.7e-06 26.7 0.0 6.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 CDI80890.1 - 0.0041 17.0 2.5 0.014 15.2 2.5 1.9 1 1 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 CDI80890.1 - 0.021 14.8 3.9 0.043 13.8 3.9 1.6 1 0 0 1 1 1 0 Ion channel ABC2_membrane_4 PF12730.7 CDI80890.1 - 6.8 6.6 9.0 11 5.9 9.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Dpy-30 PF05186.13 CDI80891.1 - 3.8e-11 42.5 0.2 6.7e-11 41.7 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif SAM35 PF10806.8 CDI80891.1 - 0.092 13.0 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex WD40 PF00400.32 CDI80894.1 - 2.2e-10 40.9 1.2 0.00011 22.9 0.0 4.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI80894.1 - 0.0015 18.8 0.0 0.0065 16.7 0.0 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDI80894.1 - 0.0042 15.8 0.4 0.014 14.1 0.1 1.9 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Herpes_TAF50 PF03326.13 CDI80894.1 - 0.042 12.5 1.0 0.052 12.2 1.0 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) CD20 PF04103.15 CDI80895.1 - 0.017 15.2 0.0 0.017 15.2 0.0 3.9 3 1 1 4 4 4 0 CD20-like family DUF2431 PF10354.9 CDI80896.1 - 9.6e-06 26.0 0.0 0.00099 19.4 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2431) PP_kinase_C_1 PF17941.1 CDI80896.1 - 5.2e-05 22.8 0.0 0.035 13.7 0.0 2.1 1 1 1 2 2 2 2 Polyphosphate kinase C-terminal domain 1 LIP1 PF15904.5 CDI80896.1 - 0.0058 16.9 2.2 5.2 7.5 0.1 3.0 2 1 1 3 3 3 2 LKB1 serine/threonine kinase interacting protein 1 COPIIcoated_ERV PF07970.12 CDI80896.1 - 0.069 13.0 0.0 6.5 6.5 0.0 2.1 1 1 1 2 2 2 0 Endoplasmic reticulum vesicle transporter Glu_dehyd_C PF16912.5 CDI80896.1 - 0.1 12.1 0.1 11 5.5 0.0 2.1 1 1 1 2 2 2 0 Glucose dehydrogenase C-terminus DUF3995 PF13160.6 CDI80899.1 - 0.0073 16.7 1.1 0.012 16.0 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3995) Phostensin PF13914.6 CDI80899.1 - 0.016 15.9 0.1 0.016 15.9 0.1 2.3 2 1 0 2 2 2 0 Phostensin PP1-binding and SH3-binding region 5TM-5TMR_LYT PF07694.12 CDI80899.1 - 0.28 10.7 1.1 0.4 10.2 1.1 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT Orf78 PF06024.12 CDI80899.1 - 0.69 10.3 2.2 7.2 7.0 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) SUIM_assoc PF16619.5 CDI80899.1 - 0.77 9.9 26.8 0.18 11.9 0.8 3.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 BRICHOS PF04089.14 CDI80899.1 - 2.2 8.6 4.2 1.5 9.1 0.2 2.3 2 0 0 2 2 2 0 BRICHOS domain RED_N PF07808.13 CDI80899.1 - 3.1 7.3 7.0 16 4.9 2.4 2.3 2 0 0 2 2 2 0 RED-like protein N-terminal region Pkinase PF00069.25 CDI80904.1 - 7.6e-29 100.9 0.2 1.9e-28 99.6 0.3 5.7 4 2 1 5 5 5 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI80904.1 - 1.5e-23 83.4 0.0 1.5e-23 83.4 0.0 2.8 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2722 PF10846.8 CDI80904.1 - 0.00011 21.3 6.2 0.00011 21.3 6.2 6.2 4 2 1 5 5 5 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI80904.1 - 0.0039 17.3 11.8 0.0039 17.3 11.8 4.6 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit CDK2AP PF09806.9 CDI80904.1 - 0.0073 16.4 8.9 0.0073 16.4 8.9 7.9 6 2 0 6 6 6 1 Cyclin-dependent kinase 2-associated protein MBOAT PF03062.19 CDI80904.1 - 0.14 11.5 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family DUF2207 PF09972.9 CDI80904.1 - 6.9 5.3 7.3 5 5.8 0.0 3.6 2 1 1 4 4 4 0 Predicted membrane protein (DUF2207) TFIIA PF03153.13 CDI80907.1 - 0.069 13.1 17.5 0.11 12.5 17.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PNISR PF15996.5 CDI80907.1 - 1.7 8.9 20.0 0.059 13.6 12.9 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR GREB1 PF15782.5 CDI80907.1 - 2 5.4 13.3 2.7 5.0 13.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hamartin PF04388.12 CDI80907.1 - 6.5 5.3 10.0 7.2 5.1 10.0 1.2 1 0 0 1 1 1 0 Hamartin protein CLP_protease PF00574.23 CDI80909.1 - 1.1e-13 51.5 0.0 1.7e-08 34.6 0.1 2.9 2 1 0 2 2 2 2 Clp protease AAA_23 PF13476.6 CDI80909.1 - 0.0019 18.7 6.0 0.051 14.1 1.3 2.3 2 0 0 2 2 2 2 AAA domain Utp11 PF03998.13 CDI80909.1 - 0.02 14.9 6.3 0.047 13.6 1.8 2.2 2 0 0 2 2 2 0 Utp11 protein DUF4230 PF14014.6 CDI80909.1 - 2.4 8.4 9.2 0.54 10.5 3.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) PIH1_CS PF18201.1 CDI80910.1 - 8e-06 26.2 0.1 1.9e-05 25.0 0.1 1.7 1 0 0 1 1 1 1 PIH1 CS-like domain DUF4757 PF15949.5 CDI80910.1 - 0.023 15.2 2.2 0.023 15.2 2.2 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4757) UCH PF00443.29 CDI80911.1 - 0.002 17.7 3.6 0.0029 17.1 3.6 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase LcrG PF07216.12 CDI80911.1 - 1.4 8.9 8.8 2.8 7.9 8.8 1.5 1 0 0 1 1 1 0 LcrG protein HI0933_like PF03486.14 CDI80911.1 - 1.6 7.3 3.9 2.1 6.9 3.9 1.2 1 0 0 1 1 1 0 HI0933-like protein OmpH PF03938.14 CDI80911.1 - 7.2 7.0 15.7 12 6.3 15.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ANAPC4_WD40 PF12894.7 CDI80913.1 - 2.3e-05 24.6 0.0 0.35 11.2 0.0 3.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI80913.1 - 0.00021 22.0 1.7 1.5 9.9 0.0 4.3 3 1 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 CDI80914.1 - 0.013 16.4 0.1 10 7.2 0.0 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat PAD_M PF08527.10 CDI80914.1 - 0.14 11.8 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain CitMHS PF03600.16 CDI80916.1 - 0.054 12.7 0.0 0.1 11.8 0.0 1.5 1 1 0 1 1 1 0 Citrate transporter m04gp34like PF12216.8 CDI80916.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Immune evasion protein DcuA_DcuB PF03605.14 CDI80917.1 - 0.0018 17.3 2.2 0.0026 16.7 2.2 1.1 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter Tweety PF04906.13 CDI80917.1 - 0.004 15.9 0.4 0.007 15.1 0.4 1.4 1 0 0 1 1 1 1 Tweety Yip1 PF04893.17 CDI80917.1 - 0.073 12.8 5.1 0.062 13.0 3.3 1.8 2 1 0 2 2 2 0 Yip1 domain Phage_holin_3_6 PF07332.11 CDI80917.1 - 0.4 10.7 5.9 0.12 12.5 2.5 1.8 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Tetraspanin PF00335.20 CDI80917.1 - 4.4 6.9 7.5 17 5.1 7.7 1.7 1 1 0 1 1 1 0 Tetraspanin family Ribosomal_L13 PF00572.18 CDI80921.1 - 4.3e-21 75.4 0.1 2e-20 73.3 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein L13 AAA PF00004.29 CDI80922.1 - 5.3e-43 146.6 0.1 1.7e-42 144.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI80922.1 - 6.8e-11 41.8 0.5 1.3e-10 40.9 0.5 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDI80922.1 - 8.9e-10 38.4 0.0 2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 CDI80922.1 - 2.9e-06 27.5 0.0 7.1e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDI80922.1 - 3.1e-06 27.5 0.1 0.0038 17.5 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CDI80922.1 - 2.5e-05 24.1 0.0 5.3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 CDI80922.1 - 4.5e-05 22.7 0.0 7.9e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CDI80922.1 - 5.2e-05 23.7 0.0 0.0024 18.3 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CDI80922.1 - 0.00013 22.0 0.1 0.00066 19.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI80922.1 - 0.0021 18.6 0.0 0.007 16.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 CDI80922.1 - 0.0037 17.0 0.0 0.007 16.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CDI80922.1 - 0.0038 17.3 0.0 0.0099 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDI80922.1 - 0.0039 17.4 0.0 0.015 15.5 0.0 1.9 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 CDI80922.1 - 0.0064 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_28 PF13521.6 CDI80922.1 - 0.0079 16.5 0.2 0.022 15.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 CDI80922.1 - 0.008 15.6 0.4 0.02 14.3 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CDI80922.1 - 0.018 15.5 0.0 0.036 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 CDI80922.1 - 0.032 14.1 0.1 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDI80922.1 - 0.035 13.8 0.2 0.096 12.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDI80922.1 - 0.045 13.3 0.3 0.33 10.5 0.1 2.2 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 CDI80922.1 - 0.048 12.8 0.0 0.58 9.3 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain PhoH PF02562.16 CDI80922.1 - 0.071 12.6 0.1 0.17 11.3 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 CDI80922.1 - 0.085 12.4 0.0 0.21 11.1 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CDI80922.1 - 0.089 12.7 0.0 0.53 10.2 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_30 PF13604.6 CDI80922.1 - 0.1 12.3 0.2 0.34 10.6 0.2 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CDI80922.1 - 0.11 11.8 0.1 1.2 8.5 0.1 2.2 1 1 1 2 2 2 0 KaiC Prot_ATP_OB_N PF17758.1 CDI80922.1 - 0.12 12.1 0.0 0.35 10.6 0.0 1.8 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain ABC_tran PF00005.27 CDI80922.1 - 0.12 12.8 0.3 1.2 9.7 0.0 2.7 3 0 0 3 3 2 0 ABC transporter NTPase_1 PF03266.15 CDI80922.1 - 0.14 12.1 0.2 0.96 9.3 0.0 2.3 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 CDI80922.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 CDI80922.1 - 0.2 10.7 0.0 0.34 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_6 PF12774.7 CDI80923.1 - 6.4e-47 160.1 0.2 3.1e-29 102.0 0.0 4.0 2 1 2 4 4 4 3 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 CDI80923.1 - 9.3e-44 149.1 0.0 9.1e-37 126.3 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 CDI80923.1 - 4e-11 43.1 0.0 0.014 15.4 0.0 4.3 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI80923.1 - 7.6e-09 36.2 5.3 0.0015 18.9 0.0 3.5 3 1 1 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 CDI80923.1 - 8.8e-09 35.7 0.0 0.00062 20.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CDI80923.1 - 8.9e-07 28.2 0.0 0.016 14.3 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein Sigma54_activat PF00158.26 CDI80923.1 - 7.6e-06 25.7 0.2 0.005 16.5 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 CDI80923.1 - 2e-05 25.0 0.0 0.0062 17.0 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDI80923.1 - 2.1e-05 24.1 0.2 0.29 10.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF2075 PF09848.9 CDI80923.1 - 2.6e-05 23.6 0.0 0.093 12.0 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 CDI80923.1 - 7.9e-05 23.2 0.3 0.23 12.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_19 PF13245.6 CDI80923.1 - 8.4e-05 22.9 0.1 0.32 11.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDI80923.1 - 8.9e-05 22.3 13.2 0.0079 15.9 0.0 3.2 3 1 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CDI80923.1 - 0.00011 22.1 0.3 0.12 12.2 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 CDI80923.1 - 0.00016 21.9 0.0 0.021 15.0 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 CDI80923.1 - 0.00017 21.6 0.0 0.013 15.5 0.0 3.3 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 CDI80923.1 - 0.00022 21.2 0.4 0.27 11.1 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA_18 PF13238.6 CDI80923.1 - 0.00023 21.7 0.1 0.15 12.6 0.0 2.8 3 0 0 3 3 2 1 AAA domain Viral_helicase1 PF01443.18 CDI80923.1 - 0.00025 20.9 0.1 0.055 13.2 0.1 2.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CDI80923.1 - 0.00043 20.3 0.0 0.016 15.1 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Guanylate_kin PF00625.21 CDI80923.1 - 0.00055 19.7 0.1 0.13 12.0 0.0 2.5 2 0 0 2 2 2 1 Guanylate kinase DUF815 PF05673.13 CDI80923.1 - 0.00056 19.1 0.4 0.68 9.0 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) NB-ARC PF00931.22 CDI80923.1 - 0.00068 18.9 0.0 0.036 13.2 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 CDI80923.1 - 0.00074 18.8 0.9 0.14 11.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin TrwB_AAD_bind PF10412.9 CDI80923.1 - 0.0014 17.6 0.3 0.33 9.8 0.1 2.8 3 0 0 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 CDI80923.1 - 0.0017 17.9 0.1 0.059 13.0 0.0 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 CDI80923.1 - 0.0025 18.2 0.0 0.68 10.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.21 CDI80923.1 - 0.0034 16.8 3.0 0.23 10.8 0.0 2.6 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI UvrD-helicase PF00580.21 CDI80923.1 - 0.0051 16.4 0.5 0.8 9.2 0.3 2.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_33 PF13671.6 CDI80923.1 - 0.0055 16.9 0.1 0.93 9.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 CDI80923.1 - 0.007 16.6 0.1 2.4 8.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CDI80923.1 - 0.009 16.1 0.5 0.26 11.3 0.1 2.9 3 0 0 3 3 2 1 Helicase HerA, central domain TsaE PF02367.17 CDI80923.1 - 0.0095 15.9 0.1 0.088 12.8 0.0 2.1 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 CDI80923.1 - 0.013 15.6 0.2 6.4 6.9 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase SRPRB PF09439.10 CDI80923.1 - 0.018 14.5 0.1 0.15 11.4 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Sigma54_activ_2 PF14532.6 CDI80923.1 - 0.018 15.1 0.1 0.21 11.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain PRK PF00485.18 CDI80923.1 - 0.027 14.2 5.8 1.7 8.3 1.1 2.6 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 CDI80923.1 - 0.03 14.1 0.1 0.81 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CDI80923.1 - 0.039 13.3 0.3 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Septin PF00735.18 CDI80923.1 - 0.049 12.9 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Septin ATP_bind_1 PF03029.17 CDI80923.1 - 0.057 13.2 0.2 8.5 6.1 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SRP54 PF00448.22 CDI80923.1 - 0.08 12.6 0.2 11 5.6 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain G-alpha PF00503.20 CDI80923.1 - 0.082 12.0 0.4 5.8 6.0 0.1 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Rad17 PF03215.15 CDI80923.1 - 0.087 12.7 0.0 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain IstB_IS21 PF01695.17 CDI80923.1 - 0.093 12.4 0.1 9.8 5.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CDI80923.1 - 0.095 12.6 0.0 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_35 PF14516.6 CDI80923.1 - 0.097 11.5 0.1 0.24 10.2 0.1 1.6 1 0 0 1 1 1 0 AAA-like domain AIG1 PF04548.16 CDI80923.1 - 0.11 11.8 0.3 2.2 7.5 0.0 2.5 3 0 0 3 3 2 0 AIG1 family APS_kinase PF01583.20 CDI80923.1 - 0.15 11.9 0.2 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase TIP49 PF06068.13 CDI80923.1 - 0.22 10.7 0.7 2.3 7.3 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_23 PF13476.6 CDI80923.1 - 0.23 11.9 4.2 1.4 9.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain DUF995 PF06191.12 CDI80923.1 - 0.31 10.7 0.0 0.31 10.7 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF995) Ribosomal_60s PF00428.19 CDI80923.1 - 9.5 6.9 32.9 0.3 11.7 9.6 3.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein Apt1 PF10351.9 CDI80923.1 - 10 4.9 21.4 4.3 6.1 9.6 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain RR_TM4-6 PF06459.12 CDI80925.1 - 0.0021 17.9 12.6 0.0024 17.8 12.6 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 CDI80925.1 - 0.0026 18.4 20.5 0.0041 17.8 20.5 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region eIF-3_zeta PF05091.12 CDI80925.1 - 0.098 11.6 13.6 0.1 11.6 13.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI80925.1 - 0.2 11.7 36.3 0.22 11.5 36.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI80925.1 - 0.22 11.6 6.7 0.2 11.7 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI80925.1 - 0.27 9.3 9.8 0.24 9.5 9.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI80925.1 - 0.3 9.8 17.6 0.35 9.6 17.6 1.2 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 CDI80925.1 - 0.41 10.1 13.5 0.45 9.9 13.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SID-1_RNA_chan PF13965.6 CDI80925.1 - 0.58 8.5 2.3 0.5 8.7 2.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 CDI80925.1 - 0.91 8.5 13.8 1 8.3 13.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 CDI80925.1 - 1.1 8.4 2.5 1.1 8.4 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ctr PF04145.15 CDI80925.1 - 1.1 9.9 5.6 1.5 9.4 5.6 1.4 1 0 0 1 1 1 0 Ctr copper transporter family FAM60A PF15396.6 CDI80925.1 - 1.1 9.2 12.3 1.4 8.9 12.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Serinc PF03348.15 CDI80925.1 - 3.3 6.5 4.0 3.2 6.6 4.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CPSF100_C PF13299.6 CDI80925.1 - 6 7.0 11.6 8.4 6.5 11.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sel1 PF08238.12 CDI80926.1 - 9.7e-26 89.6 14.0 0.00018 22.0 0.0 9.7 9 0 0 9 9 9 6 Sel1 repeat SID-1_RNA_chan PF13965.6 CDI80926.1 - 9.9 4.4 5.5 10 4.4 3.2 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PAG PF15347.6 CDI80928.1 - 0.073 12.1 0.0 0.097 11.7 0.0 1.1 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched RskA PF10099.9 CDI80929.1 - 0.00014 22.3 0.1 0.00023 21.5 0.1 1.4 1 1 0 1 1 1 1 Anti-sigma-K factor rskA HemX PF04375.14 CDI80929.1 - 0.00027 20.3 21.7 0.00034 20.0 21.7 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase PA26 PF04636.13 CDI80929.1 - 0.00045 19.3 4.9 0.00051 19.1 4.9 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Peptidase_S49_N PF08496.10 CDI80929.1 - 0.0055 16.8 6.5 0.0069 16.5 6.5 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal LMBR1 PF04791.16 CDI80929.1 - 0.0058 15.6 0.9 0.0091 15.0 0.9 1.3 1 0 0 1 1 1 1 LMBR1-like membrane protein CSG2 PF16965.5 CDI80929.1 - 0.0059 15.6 1.9 0.0074 15.3 1.9 1.1 1 0 0 1 1 1 1 Ceramide synthase regulator Folate_carrier PF01770.18 CDI80929.1 - 0.0069 15.2 0.5 0.0095 14.7 0.5 1.3 1 0 0 1 1 1 1 Reduced folate carrier DDHD PF02862.17 CDI80929.1 - 0.0071 16.5 5.6 0.0075 16.4 5.6 1.1 1 0 0 1 1 1 1 DDHD domain SID-1_RNA_chan PF13965.6 CDI80929.1 - 0.0075 14.7 1.2 0.0086 14.5 1.2 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF2048 PF09752.9 CDI80929.1 - 0.011 14.8 0.2 0.012 14.7 0.2 1.0 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Zip PF02535.22 CDI80929.1 - 0.023 13.9 1.6 0.027 13.7 1.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MBR1 PF17058.5 CDI80929.1 - 0.026 14.9 5.0 0.03 14.6 5.0 1.1 1 0 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 V_ATPase_I PF01496.19 CDI80929.1 - 0.034 12.1 9.0 0.035 12.0 9.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 CDI80929.1 - 0.036 13.0 3.5 0.044 12.7 3.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.7 CDI80929.1 - 0.039 12.1 7.1 0.041 12.0 7.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TFIIA PF03153.13 CDI80929.1 - 0.048 13.7 22.0 0.052 13.5 22.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myco_haema PF05692.12 CDI80929.1 - 0.048 12.6 5.3 0.056 12.4 5.3 1.0 1 0 0 1 1 1 0 Mycoplasma haemagglutinin Trypan_PARP PF05887.11 CDI80929.1 - 0.05 13.6 0.3 0.062 13.3 0.3 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RR_TM4-6 PF06459.12 CDI80929.1 - 0.051 13.4 15.5 0.058 13.2 15.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NEMP PF10225.9 CDI80929.1 - 0.053 13.2 0.9 0.069 12.8 0.9 1.3 1 0 0 1 1 1 0 NEMP family DUF1980 PF09323.10 CDI80929.1 - 0.056 13.4 2.5 0.084 12.8 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Otopetrin PF03189.13 CDI80929.1 - 0.062 12.1 1.0 0.075 11.8 1.0 1.1 1 0 0 1 1 1 0 Otopetrin CLN3 PF02487.17 CDI80929.1 - 0.062 12.3 5.0 0.066 12.3 5.0 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2052 PF09747.9 CDI80929.1 - 0.076 13.1 18.8 0.091 12.9 18.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SpoIIP PF07454.11 CDI80929.1 - 0.079 12.4 14.0 0.091 12.2 14.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4611 PF15387.6 CDI80929.1 - 0.086 13.1 13.7 0.12 12.6 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PIP5K PF01504.18 CDI80929.1 - 0.098 11.9 4.1 0.1 11.8 4.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF2457 PF10446.9 CDI80929.1 - 0.14 11.3 12.9 0.16 11.1 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) UPF0565 PF10561.9 CDI80929.1 - 0.15 11.2 4.8 0.19 10.9 4.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DUF2126 PF09899.9 CDI80929.1 - 0.16 10.0 5.7 0.17 9.9 5.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF3292 PF11696.8 CDI80929.1 - 0.19 10.1 7.7 0.21 9.9 7.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) CPSF100_C PF13299.6 CDI80929.1 - 0.21 11.8 11.5 0.25 11.5 11.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal GAGA_bind PF06217.12 CDI80929.1 - 0.23 11.7 10.5 0.28 11.4 10.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF5520 PF17658.1 CDI80929.1 - 0.25 10.4 8.5 0.32 10.1 8.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) ATP11 PF06644.11 CDI80929.1 - 0.25 11.1 15.5 0.29 10.9 15.5 1.1 1 0 0 1 1 1 0 ATP11 protein DUF913 PF06025.12 CDI80929.1 - 0.25 10.3 7.7 0.29 10.1 7.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4471 PF14740.6 CDI80929.1 - 0.27 10.4 10.2 0.29 10.3 10.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) XRCC4 PF06632.12 CDI80929.1 - 0.3 9.9 15.3 0.34 9.7 15.3 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Neur_chan_memb PF02932.16 CDI80929.1 - 0.31 11.1 5.4 0.34 10.9 5.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2347 PF09804.9 CDI80929.1 - 0.33 10.5 4.0 0.35 10.4 4.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF4746 PF15928.5 CDI80929.1 - 0.33 10.3 15.1 0.37 10.2 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paramyxo_ncap PF00973.19 CDI80929.1 - 0.36 9.7 7.4 0.37 9.6 7.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein ALMT PF11744.8 CDI80929.1 - 0.36 9.6 9.3 0.4 9.5 9.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Cob_adeno_trans PF01923.18 CDI80929.1 - 0.38 10.9 7.5 0.47 10.6 7.5 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Afi1 PF07792.12 CDI80929.1 - 0.44 11.0 11.5 0.52 10.8 11.5 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Tho2 PF11262.8 CDI80929.1 - 0.46 9.6 12.4 0.54 9.4 12.4 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Het-C PF07217.11 CDI80929.1 - 0.53 8.8 9.2 0.61 8.5 9.2 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C TERB2 PF15101.6 CDI80929.1 - 0.57 10.2 14.4 0.76 9.8 14.4 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 D123 PF07065.14 CDI80929.1 - 0.63 9.1 10.4 0.76 8.9 10.4 1.1 1 0 0 1 1 1 0 D123 Inhibitor_I71 PF12628.7 CDI80929.1 - 0.68 9.8 4.8 0.93 9.3 4.8 1.2 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Isy1 PF06246.12 CDI80929.1 - 0.74 9.3 19.1 0.88 9.1 19.1 1.1 1 0 0 1 1 1 0 Isy1-like splicing family UBN_AB PF14075.6 CDI80929.1 - 0.75 9.5 17.2 0.98 9.1 17.2 1.1 1 0 0 1 1 1 0 Ubinuclein conserved middle domain SLC12 PF03522.15 CDI80929.1 - 0.77 8.7 12.0 0.88 8.5 12.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF1266 PF06889.11 CDI80929.1 - 0.79 9.8 8.2 1 9.4 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) DUF4192 PF13830.6 CDI80929.1 - 0.8 9.7 4.5 0.59 10.1 3.5 1.3 2 0 0 2 2 1 0 Domain of unknown function (DUF4192) O-antigen_lig PF13425.6 CDI80929.1 - 0.82 8.4 4.2 0.88 8.3 4.2 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Tim54 PF11711.8 CDI80929.1 - 0.83 8.4 13.3 0.96 8.2 13.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF853 PF05872.12 CDI80929.1 - 0.89 8.1 8.9 1 7.9 8.9 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) BORG_CEP PF14957.6 CDI80929.1 - 0.91 10.7 8.1 1.1 10.4 8.1 1.1 1 0 0 1 1 1 0 Cdc42 effector Golgin_A5 PF09787.9 CDI80929.1 - 0.97 8.8 26.9 1.2 8.5 26.9 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 CDC45 PF02724.14 CDI80929.1 - 0.99 7.6 18.3 1.2 7.4 18.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Band_3_cyto PF07565.13 CDI80929.1 - 1 9.1 10.5 1.2 8.9 10.5 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Peptidase_S64 PF08192.11 CDI80929.1 - 1.1 7.7 10.4 1.2 7.5 10.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4045 PF13254.6 CDI80929.1 - 1.1 8.8 12.2 1.4 8.5 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) NARP1 PF12569.8 CDI80929.1 - 1.1 8.0 13.1 1.2 7.9 13.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Gti1_Pac2 PF09729.9 CDI80929.1 - 1.2 9.2 9.0 1.6 8.8 9.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family GNAT_acetyltr_2 PF13718.6 CDI80929.1 - 1.3 8.4 10.9 1.6 8.1 10.9 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF4407 PF14362.6 CDI80929.1 - 1.3 8.3 13.1 2 7.7 13.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 CDI80929.1 - 1.3 7.6 14.4 1.5 7.3 14.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Folliculin PF11704.8 CDI80929.1 - 1.3 8.9 10.0 1.7 8.5 10.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport MRNIP PF15749.5 CDI80929.1 - 1.4 9.7 21.0 1.9 9.2 21.0 1.2 1 0 0 1 1 1 0 MRN-interacting protein HAUS6_N PF14661.6 CDI80929.1 - 1.4 8.4 15.8 1.7 8.2 15.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Vfa1 PF08432.10 CDI80929.1 - 1.5 9.1 20.0 1.8 8.9 20.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Cellulose_synt PF03552.14 CDI80929.1 - 1.6 7.1 2.7 1.6 7.1 2.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Peptidase_S30 PF01577.16 CDI80929.1 - 1.6 8.3 13.6 2.1 7.9 13.6 1.1 1 0 0 1 1 1 0 Potyvirus P1 protease PBP_sp32 PF07222.12 CDI80929.1 - 1.7 8.1 18.5 2.1 7.7 18.5 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 EIIBC-GUT_N PF03612.14 CDI80929.1 - 1.7 8.4 12.0 2.2 8.0 12.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Drc1-Sld2 PF11719.8 CDI80929.1 - 1.8 8.0 16.5 2.1 7.8 16.5 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein TP53IP5 PF15331.6 CDI80929.1 - 1.8 8.6 12.2 2.2 8.4 12.2 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 FAM150 PF15129.6 CDI80929.1 - 2.1 8.5 10.6 3.1 8.0 10.6 1.3 1 0 0 1 1 1 0 FAM150 family Med17 PF10156.9 CDI80929.1 - 2.1 7.0 20.3 2.5 6.7 20.3 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Peptidase_U57 PF05582.12 CDI80929.1 - 2.3 7.4 9.9 2.6 7.2 9.9 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Membralin PF09746.9 CDI80929.1 - 2.3 7.1 6.8 2.7 6.9 6.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein GOLD_2 PF13897.6 CDI80929.1 - 2.4 8.6 7.1 3.3 8.2 7.1 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking PTPRCAP PF15713.5 CDI80929.1 - 2.5 8.4 20.0 3.2 8.0 20.0 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated AIF_C PF14721.6 CDI80929.1 - 2.7 8.4 9.5 3.7 7.9 9.5 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM176 PF14851.6 CDI80929.1 - 2.7 7.6 13.9 4.3 7.0 13.9 1.3 1 0 0 1 1 1 0 FAM176 family Paf1 PF03985.13 CDI80929.1 - 3 6.8 24.9 3.5 6.5 24.9 1.0 1 0 0 1 1 1 0 Paf1 PPL5 PF18168.1 CDI80929.1 - 3.1 7.0 9.2 3.7 6.7 9.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CCSAP PF15748.5 CDI80929.1 - 3.2 7.9 17.8 3.8 7.6 17.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated AAA_11 PF13086.6 CDI80929.1 - 3.2 7.4 16.0 3.8 7.2 16.0 1.0 1 0 0 1 1 1 0 AAA domain PIEZO PF15917.5 CDI80929.1 - 3.3 7.1 19.6 4.2 6.8 19.6 1.1 1 0 0 1 1 1 0 Piezo DUF3573 PF12097.8 CDI80929.1 - 3.4 6.4 5.9 4.3 6.1 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Sporozoite_P67 PF05642.11 CDI80929.1 - 3.7 5.5 11.3 4.2 5.3 11.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Spore_coat_CotO PF14153.6 CDI80929.1 - 3.7 7.4 25.2 4.5 7.1 25.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Spt20 PF12090.8 CDI80929.1 - 3.7 7.1 27.4 5.5 6.5 27.4 1.3 1 0 0 1 1 1 0 Spt20 family HSP70 PF00012.20 CDI80929.1 - 4.4 5.4 14.3 4.8 5.2 14.3 1.0 1 0 0 1 1 1 0 Hsp70 protein Connexin PF00029.19 CDI80929.1 - 4.5 7.0 12.3 5.7 6.6 12.3 1.2 1 0 0 1 1 1 0 Connexin Peroxin-13_N PF04088.13 CDI80929.1 - 4.6 7.5 7.1 7 6.9 7.1 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM60A PF15396.6 CDI80929.1 - 4.8 7.1 11.9 6 6.8 11.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TFB6 PF17110.5 CDI80929.1 - 5.3 6.8 11.0 7 6.4 11.0 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Plasmodium_Vir PF05795.11 CDI80929.1 - 5.4 6.3 10.2 6.1 6.1 10.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CemA PF03040.14 CDI80929.1 - 5.7 6.8 7.7 6.5 6.6 7.7 1.1 1 0 0 1 1 1 0 CemA family DUF4637 PF15470.6 CDI80929.1 - 6.1 6.5 17.0 8.4 6.1 17.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Phlebovirus_NSM PF07246.11 CDI80929.1 - 6.3 6.1 11.1 8.2 5.7 11.1 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Pex26 PF07163.12 CDI80929.1 - 6.4 6.0 11.9 8.9 5.5 11.9 1.3 1 0 0 1 1 1 0 Pex26 protein YABBY PF04690.13 CDI80929.1 - 7.3 7.1 10.2 8.7 6.9 10.2 1.1 1 0 0 1 1 1 0 YABBY protein CAF1 PF04857.20 CDI80929.1 - 7.5 5.6 11.1 8.5 5.4 11.1 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease FAM222A PF15258.6 CDI80929.1 - 7.6 5.5 17.4 8.7 5.3 17.4 1.0 1 0 0 1 1 1 0 Protein family of FAM222A DUF2828 PF11443.8 CDI80929.1 - 7.7 4.5 13.6 8.9 4.3 13.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3276 PF11680.8 CDI80929.1 - 8.3 6.6 14.8 11 6.1 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) CENP-I PF07778.11 CDI80929.1 - 8.4 5.0 14.7 11 4.6 14.7 1.1 1 0 0 1 1 1 0 Mis6 CobT PF06213.12 CDI80929.1 - 8.4 5.7 28.0 11 5.3 28.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT GDA1_CD39 PF01150.17 CDI80930.1 - 1.4e-13 50.3 0.0 8.3e-13 47.8 0.0 2.2 2 1 0 2 2 2 1 GDA1/CD39 (nucleoside phosphatase) family Ndc1_Nup PF09531.10 CDI80930.1 - 1.3 7.7 5.3 2.2 6.9 5.3 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 CDI80930.1 - 1.8 7.5 8.3 3.4 6.6 8.3 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Tim54 PF11711.8 CDI80930.1 - 4.6 5.9 10.4 19 3.9 10.3 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF1387 PF07139.11 CDI80930.1 - 4.9 6.8 13.1 13 5.5 13.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Peptidase_S64 PF08192.11 CDI80930.1 - 5.6 5.3 7.5 9.4 4.6 7.5 1.3 1 0 0 1 1 1 0 Peptidase family S64 RabGAP-TBC PF00566.18 CDI80931.1 - 4.5e-32 111.4 4.1 1.2e-16 61.1 0.0 3.1 3 1 0 3 3 3 2 Rab-GTPase-TBC domain SlyX PF04102.12 CDI80931.1 - 0.038 14.6 4.0 3.3 8.4 0.0 2.9 2 0 0 2 2 2 0 SlyX Mucin PF01456.17 CDI80932.1 - 2.2e-06 27.7 5.4 3.7e-06 27.0 5.4 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein SSP160 PF06933.11 CDI80932.1 - 0.21 9.8 11.5 0.32 9.2 11.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Sec7 PF01369.20 CDI80935.1 - 3.2e-66 222.5 0.0 5.2e-66 221.8 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CDI80935.1 - 1.1e-11 44.8 0.0 6.7e-11 42.3 0.0 2.5 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF4834 PF16118.5 CDI80935.1 - 2.6 9.1 5.9 19 6.3 0.3 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ASH PF15780.5 CDI80936.1 - 6.8e-06 26.2 0.5 0.99 9.7 0.0 5.4 7 0 0 7 7 7 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 CDI80936.1 - 0.33 11.1 1.5 14 5.9 0.1 3.5 4 0 0 4 4 4 0 Flagellar-associated PapD-like PAZ PF02170.22 CDI80937.1 - 3.9e-09 36.4 0.1 2.2e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 PAZ domain Piwi PF02171.17 CDI80937.1 - 3.2e-08 33.2 0.0 1.8e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Piwi domain WGG PF10273.9 CDI80938.1 - 1.9e-23 82.9 1.0 1.9e-23 82.9 1.0 1.8 2 1 0 2 2 2 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 CDI80938.1 - 0.0081 16.3 0.0 0.0081 16.3 0.0 2.1 3 0 0 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Tautomerase_2 PF14552.6 CDI80938.1 - 0.033 14.3 0.1 0.06 13.4 0.1 1.6 1 0 0 1 1 1 0 Tautomerase enzyme AMP-binding_C_2 PF14535.6 CDI80938.1 - 0.091 13.1 0.2 0.86 10.0 0.1 2.2 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain TPR_2 PF07719.17 CDI80939.1 - 1.2e-07 31.3 14.1 0.004 17.2 0.5 4.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDI80939.1 - 8.4e-06 25.4 11.3 0.062 13.1 0.8 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat Caldesmon PF02029.15 CDI80939.1 - 0.00019 20.3 3.6 0.00019 20.3 3.6 5.6 4 2 1 5 5 5 1 Caldesmon TPR_11 PF13414.6 CDI80939.1 - 0.021 14.5 4.7 1.3 8.8 0.4 3.3 2 1 1 3 3 3 0 TPR repeat TPR_8 PF13181.6 CDI80939.1 - 0.044 14.0 6.4 0.24 11.7 0.2 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDI80939.1 - 0.33 11.4 3.7 0.6 10.6 0.4 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDI80939.1 - 3.8 8.3 12.3 35 5.3 0.1 5.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Sporozoite_P67 PF05642.11 CDI80941.1 - 0.095 10.8 3.4 0.31 9.1 3.4 1.8 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SPX PF03105.19 CDI80941.1 - 0.25 11.2 29.7 0.047 13.6 11.1 3.9 2 2 0 2 2 2 0 SPX domain DcuC PF03606.15 CDI80941.1 - 0.29 9.5 2.0 0.51 8.7 0.0 2.2 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier RskA PF10099.9 CDI80941.1 - 1.4 9.2 0.0 1.4 9.2 0.0 10.0 6 1 1 7 7 7 0 Anti-sigma-K factor rskA Lin-8 PF03353.15 CDI80941.1 - 2 7.9 44.1 0.061 12.9 9.2 5.1 5 0 0 5 5 5 0 Ras-mediated vulval-induction antagonist SR-25 PF10500.9 CDI80942.1 - 0.0031 17.2 16.0 0.0031 17.2 16.0 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Afi1 PF07792.12 CDI80942.1 - 0.062 13.8 2.4 0.065 13.7 2.4 1.0 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF755 PF05501.11 CDI80942.1 - 0.066 13.5 19.6 0.076 13.3 19.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Androgen_recep PF02166.16 CDI80942.1 - 0.34 9.7 6.4 0.38 9.5 6.4 1.0 1 0 0 1 1 1 0 Androgen receptor Hydrolase PF00702.26 CDI80947.1 - 4.7e-31 108.7 3.6 4.7e-31 108.7 3.6 3.0 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI80947.1 - 1.8e-28 99.3 13.5 4.1e-28 98.1 3.5 3.4 2 1 0 2 2 2 1 E1-E2 ATPase HAD PF12710.7 CDI80947.1 - 0.00063 20.2 3.0 0.00079 19.9 0.2 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDI80947.1 - 0.0051 16.6 4.6 0.069 12.9 0.6 3.0 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase ODV-E18 PF10717.9 CDI80947.1 - 0.0066 16.3 2.2 0.015 15.2 2.2 1.5 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 DUF1708 PF08101.11 CDI80947.1 - 0.0067 15.6 6.8 0.011 14.9 6.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) PIP5K PF01504.18 CDI80947.1 - 0.02 14.1 2.0 0.084 12.1 2.0 1.8 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase XRN_M PF17846.1 CDI80947.1 - 0.023 13.7 2.9 0.039 12.9 2.9 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Neur_chan_memb PF02932.16 CDI80947.1 - 0.089 12.8 4.1 0.25 11.4 4.1 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 CDI80947.1 - 0.13 12.2 7.1 0.076 12.9 3.9 2.2 2 0 0 2 2 2 0 Velvet factor SURF2 PF05477.11 CDI80947.1 - 0.24 11.0 8.2 0.47 10.1 8.2 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF2828 PF11443.8 CDI80947.1 - 0.28 9.2 7.3 0.47 8.5 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FAM176 PF14851.6 CDI80947.1 - 0.37 10.5 2.1 1.7 8.3 0.8 2.4 2 0 0 2 2 2 0 FAM176 family FAM60A PF15396.6 CDI80947.1 - 1.1 9.3 6.3 2.5 8.0 6.3 1.5 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 CDI80947.1 - 1.1 8.3 7.9 1.8 7.5 7.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF2722 PF10846.8 CDI80947.1 - 1.1 8.1 34.2 0.0098 14.9 10.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Zip PF02535.22 CDI80947.1 - 1.4 8.0 5.6 2.9 7.0 4.7 1.7 1 1 0 1 1 1 0 ZIP Zinc transporter Eapp_C PF10238.9 CDI80947.1 - 2 8.5 11.4 0.87 9.7 1.4 3.3 3 0 0 3 3 3 0 E2F-associated phosphoprotein V_ATPase_I PF01496.19 CDI80947.1 - 2.4 6.0 9.5 10 3.9 10.4 1.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 CDI80947.1 - 2.5 6.1 8.0 4 5.4 8.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 CDI80947.1 - 4.3 7.1 13.5 0.42 10.4 8.7 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 CDI80947.1 - 5.1 6.4 10.4 9.5 5.5 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ALMT PF11744.8 CDI80947.1 - 6.2 5.5 7.0 11 4.7 7.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Paf67 PF10255.9 CDI80959.1 - 3.1e-117 392.0 1.0 1.9e-115 386.1 1.0 2.3 1 1 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 CDI80959.1 - 0.016 15.3 1.5 0.028 14.5 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3067 PF11267.8 CDI80959.1 - 0.041 14.5 0.2 0.21 12.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3067) DUF1440 PF07274.12 CDI80959.1 - 0.11 12.8 0.5 0.32 11.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1440) Spore_GerAC PF05504.11 CDI80959.1 - 0.17 12.1 4.4 0.18 12.0 0.1 2.7 3 0 0 3 3 3 0 Spore germination B3/ GerAC like, C-terminal NT-C2 PF10358.9 CDI80960.1 - 0.00055 19.7 0.0 0.046 13.5 0.0 2.5 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins DUF99 PF01949.16 CDI80960.1 - 1.3 8.4 5.8 5.8 6.3 1.3 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF99 Presenilin PF01080.17 CDI80963.1 - 0.00028 19.8 12.5 0.00028 19.8 12.5 7.1 4 2 0 4 4 4 1 Presenilin BUD22 PF09073.10 CDI80963.1 - 0.00067 19.1 0.0 0.00067 19.1 0.0 6.8 4 2 2 6 6 6 1 BUD22 TFIIA PF03153.13 CDI80963.1 - 0.0008 19.5 17.7 0.0008 19.5 17.7 9.9 3 2 5 9 9 9 2 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 CDI80964.1 - 1.2e-19 70.8 0.0 1.2e-19 70.8 0.0 3.4 2 2 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CDI80964.1 - 5.3e-18 65.3 0.0 5.3e-18 65.3 0.0 3.0 2 1 0 2 2 2 1 Kinase-like Pkinase_Tyr PF07714.17 CDI80964.1 - 8.1e-09 35.1 0.1 4.9e-08 32.6 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase LRR_8 PF13855.6 CDI80965.1 - 2.8e-07 30.2 36.0 7.3e-05 22.5 3.3 4.8 5 1 0 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 CDI80965.1 - 1.6 9.3 47.2 0.014 15.8 7.5 5.9 6 1 2 8 8 8 0 Leucine Rich repeats (2 copies) O-antigen_lig PF13425.6 CDI80966.1 - 7 5.3 9.7 9 5.0 9.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CDC27 PF09507.10 CDI80966.1 - 8.1 5.7 36.4 13 5.1 36.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Myb_DNA-binding PF00249.31 CDI80968.1 - 8.6e-12 45.1 0.0 1.6e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 CDI80968.1 - 3e-10 39.9 10.2 3e-10 39.9 10.2 3.0 4 0 0 4 4 4 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 CDI80968.1 - 5.7e-08 32.9 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain FTA4 PF13093.6 CDI80968.1 - 0.008 16.1 0.1 0.011 15.7 0.1 1.3 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Myb_DNA-bind_4 PF13837.6 CDI80968.1 - 0.066 13.6 0.3 3.4 8.1 0.1 2.8 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Corona_nucleoca PF00937.18 CDI80970.1 - 0.1 11.6 17.3 0.0089 15.1 12.2 1.8 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein Sec3_C PF09763.9 CDI80970.1 - 5.3 5.3 6.4 8.1 4.7 6.4 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec3 Asp PF00026.23 CDI80971.1 - 6.2e-06 25.8 5.5 0.095 12.1 0.0 4.8 4 1 0 4 4 4 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDI80971.1 - 0.00035 20.9 1.3 0.00035 20.9 1.3 6.4 5 1 0 5 5 5 1 Xylanase inhibitor N-terminal Caldesmon PF02029.15 CDI80971.1 - 0.0018 17.1 15.6 0.0018 17.1 15.6 3.6 3 1 0 3 3 3 2 Caldesmon TAXi_C PF14541.6 CDI80971.1 - 0.027 14.3 0.0 1.7 8.4 0.0 2.9 3 0 0 3 3 3 0 Xylanase inhibitor C-terminal Cellulose_synt PF03552.14 CDI80971.1 - 2 6.8 5.7 4.5 5.6 5.7 1.5 1 0 0 1 1 1 0 Cellulose synthase Profilin PF00235.19 CDI80973.1 - 7.3e-18 65.1 2.1 1.2e-17 64.4 2.1 1.4 1 1 0 1 1 1 1 Profilin Dehydrin PF00257.19 CDI80974.1 - 0.0067 17.0 10.5 0.0067 17.0 10.5 10.2 7 4 3 10 10 10 1 Dehydrin Maf PF02545.14 CDI80979.1 - 8.9e-38 129.7 9.0 1.7e-34 119.1 9.0 3.1 1 1 0 1 1 1 1 Maf-like protein PTPRCAP PF15713.5 CDI80979.1 - 0.0058 16.9 20.4 0.16 12.3 2.8 2.3 2 0 0 2 2 2 2 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 CDI80979.1 - 0.048 13.5 17.8 0.78 9.5 1.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 CDI80979.1 - 0.13 12.4 15.2 0.59 10.3 1.5 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ABC2_membrane_2 PF12679.7 CDI80979.1 - 0.25 10.6 0.1 0.25 10.6 0.1 2.7 2 1 0 2 2 1 0 ABC-2 family transporter protein CCSAP PF15748.5 CDI80979.1 - 0.35 11.0 38.7 0.74 9.9 11.5 2.1 1 1 1 2 2 2 0 Centriole, cilia and spindle-associated PIN_3 PF13470.6 CDI80979.1 - 0.36 11.6 0.1 0.36 11.6 0.1 2.2 2 1 0 2 2 2 0 PIN domain DUF4484 PF14831.6 CDI80979.1 - 1.1 9.2 19.1 4.5 7.2 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Otopetrin PF03189.13 CDI80979.1 - 1.2 7.9 13.0 0.34 9.7 0.6 2.1 2 0 0 2 2 2 0 Otopetrin FYDLN_acid PF09538.10 CDI80979.1 - 1.8 9.3 17.2 1.9 9.2 3.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) PNISR PF15996.5 CDI80979.1 - 2.6 8.3 26.0 4.7 7.4 5.7 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR MAT1 PF06391.13 CDI80979.1 - 2.9 7.7 29.4 3.5 7.4 5.3 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Lin-8 PF03353.15 CDI80979.1 - 3.3 7.2 40.6 2.8 7.4 0.0 3.2 2 1 1 3 3 3 0 Ras-mediated vulval-induction antagonist ESM4 PF15952.5 CDI80979.1 - 3.7 7.9 35.4 4.5 7.7 18.7 2.3 2 0 0 2 2 2 0 Enhancer of split M4 family Bac_luciferase PF00296.20 CDI80979.1 - 3.9 6.8 9.2 0.24 10.8 1.1 2.2 2 1 0 2 2 2 0 Luciferase-like monooxygenase V_ATPase_I PF01496.19 CDI80979.1 - 5.4 4.8 23.3 0.15 10.0 4.3 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family XRN_M PF17846.1 CDI80979.1 - 6.5 5.6 15.7 5.6 5.8 6.9 2.1 2 0 0 2 2 2 0 Xrn1 helical domain CLN3 PF02487.17 CDI80979.1 - 7.3 5.5 17.3 2.3 7.2 4.7 2.1 2 0 0 2 2 2 0 CLN3 protein RNase_HII PF01351.18 CDI80981.1 - 1.9e-23 83.4 5.3 4.8e-17 62.5 1.6 3.4 2 1 0 2 2 2 2 Ribonuclease HII PASTA PF03793.19 CDI80981.1 - 0.1 12.4 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 PASTA domain Abhydrolase_8 PF06259.12 CDI80982.1 - 0.00067 19.3 0.0 0.00091 18.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase Phage_holin_3_1 PF05106.12 CDI80985.1 - 0.12 12.8 0.3 5.6 7.5 0.1 2.6 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) ALAD PF00490.21 CDI80987.1 - 1.1e-121 405.9 0.1 1.4e-83 280.7 1.6 2.2 2 0 0 2 2 2 2 Delta-aminolevulinic acid dehydratase Peptidase_M16_C PF05193.21 CDI80987.1 - 2.3e-23 83.2 0.0 1.3e-13 51.3 0.0 3.7 2 2 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDI80987.1 - 9.8e-17 61.3 0.9 6e-15 55.5 0.6 2.8 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) PEP-utilisers_N PF05524.13 CDI80987.1 - 0.29 11.3 2.4 2.5 8.3 0.1 3.1 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal Methyltransf_31 PF13847.6 CDI80989.1 - 1.4e-10 41.1 0.2 3.4e-07 30.2 0.1 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CDI80989.1 - 4.8e-08 33.5 0.1 2.3e-06 28.1 0.0 2.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDI80989.1 - 5.4e-08 33.4 0.1 1.6e-07 31.9 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI80989.1 - 2e-07 31.0 0.0 5.2e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI80989.1 - 0.00027 21.6 0.1 0.00084 20.0 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDI80989.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Pox_MCEL PF03291.16 CDI80989.1 - 0.023 13.8 0.1 0.049 12.7 0.0 1.5 2 0 0 2 2 2 0 mRNA capping enzyme PrmA PF06325.13 CDI80989.1 - 0.031 13.7 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AviRa PF11599.8 CDI80989.1 - 0.13 11.7 0.3 0.22 11.0 0.3 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa DUF568 PF04526.13 CDI80990.1 - 0.088 13.5 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF568) Pex14_N PF04695.13 CDI80990.1 - 0.63 10.7 4.2 1.3 9.7 0.1 2.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EF-hand_1 PF00036.32 CDI80991.1 - 9.8e-05 21.6 0.0 0.00066 19.1 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 CDI80991.1 - 0.00027 20.6 0.0 0.0011 18.7 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 CDI80991.1 - 0.028 14.9 0.2 0.13 12.7 0.0 2.3 3 0 0 3 3 3 0 EF-hand domain pair GPHH PF16905.5 CDI80991.1 - 0.046 13.5 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated DUF2070 PF09843.9 CDI80993.1 - 2 6.6 7.5 2.9 6.1 7.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HSP90 PF00183.18 CDI80994.1 - 6.7e-234 777.6 37.1 8.9e-234 777.2 37.1 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CDI80994.1 - 2.9e-16 59.9 0.0 6e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDI80994.1 - 7.8e-10 38.7 0.1 2.4e-09 37.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 CDI80994.1 - 0.0071 16.4 1.0 0.018 15.0 0.2 2.1 2 0 0 2 2 2 1 Tumour suppressor protein Cofac_haem_bdg PF04187.13 CDI80994.1 - 0.18 11.8 2.3 0.32 11.0 0.1 2.5 2 1 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN TRAP_alpha PF03896.16 CDI80994.1 - 0.43 9.7 7.0 0.84 8.8 7.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.22 CDI80994.1 - 0.8 8.9 2.8 1.3 8.2 2.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_polI_A34 PF08208.11 CDI80994.1 - 1.4 9.0 22.9 4 7.5 22.9 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RNA_pol_Rpc4 PF05132.14 CDI80994.1 - 2.4 8.6 10.1 5.1 7.5 10.1 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 CDI80994.1 - 3.3 6.4 6.6 5.1 5.8 6.6 1.3 1 0 0 1 1 1 0 Presenilin PBP1_TM PF14812.6 CDI80995.1 - 0.033 14.5 29.9 0.32 11.4 10.1 4.4 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Helicase_C_2 PF13307.6 CDI80996.1 - 2.1e-41 141.9 3.0 2.7e-41 141.6 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain HBB PF06777.11 CDI80996.1 - 0.00048 19.9 0.0 0.0009 19.0 0.0 1.4 1 0 0 1 1 1 1 Helical and beta-bridge domain Spt20 PF12090.8 CDI80996.1 - 0.0061 16.2 20.8 0.012 15.3 20.8 1.4 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI80996.1 - 0.016 15.3 20.7 0.02 14.9 20.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI80996.1 - 0.19 10.6 15.6 0.26 10.2 15.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) EOS1 PF12326.8 CDI80996.1 - 0.21 11.5 0.8 0.33 10.9 0.8 1.3 1 0 0 1 1 1 0 N-glycosylation protein Baculo_PP31 PF05311.11 CDI80996.1 - 0.38 10.2 5.8 0.55 9.7 5.8 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Neur_chan_memb PF02932.16 CDI80996.1 - 0.84 9.7 3.0 1.2 9.2 3.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI80996.1 - 1.3 7.8 3.6 1.7 7.4 3.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4834 PF16118.5 CDI80996.1 - 3.4 8.7 8.7 6.1 7.9 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) RRM_1 PF00076.22 CDI80997.1 - 1e-74 246.3 0.0 8.1e-21 73.6 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CDI80997.1 - 1.9e-27 95.2 2.1 1e-26 92.9 1.9 2.4 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_7 PF16367.5 CDI80997.1 - 0.00033 20.7 0.0 0.95 9.6 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDI80997.1 - 0.0036 17.3 0.0 15 5.7 0.0 4.1 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CDI80997.1 - 0.095 12.6 0.0 3.5 7.6 0.0 3.0 3 0 0 3 3 3 0 Occluded RNA-recognition motif Glycolytic PF00274.19 CDI80998.1 - 8.8e-125 416.0 0.0 9.8e-125 415.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I SR-25 PF10500.9 CDI80999.1 - 0.0031 17.2 9.5 0.0031 17.2 9.5 8.1 3 3 4 7 7 7 1 Nuclear RNA-splicing-associated protein YabA PF06156.13 CDI80999.1 - 0.085 13.5 0.1 0.085 13.5 0.1 3.9 5 0 0 5 5 5 0 Initiation control protein YabA RskA PF10099.9 CDI80999.1 - 0.31 11.3 0.0 0.31 11.3 0.0 7.0 3 3 1 5 5 5 0 Anti-sigma-K factor rskA rRNA_proc-arch PF13234.6 CDI81000.1 - 9.5e-21 74.9 0.1 1.5e-20 74.2 0.1 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 CDI81000.1 - 3.8e-09 36.5 0.0 7.7e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI81000.1 - 1.8e-07 31.5 0.0 1.6e-06 28.4 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain HSP90 PF00183.18 CDI81002.1 - 1.6e-134 449.7 0.5 1.8e-83 281.3 1.0 3.1 2 1 0 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 CDI81002.1 - 1.8e-10 40.8 0.0 3.7e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDI81002.1 - 1e-07 32.4 0.2 2.3e-07 31.3 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CPSF100_C PF13299.6 CDI81002.1 - 0.26 11.4 2.8 0.4 10.8 0.1 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal LPD5 PF18799.1 CDI81002.1 - 0.55 10.6 5.7 0.11 12.9 1.4 2.1 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 5 Aminotran_5 PF00266.19 CDI81004.1 - 5.8e-18 65.0 0.0 1e-13 51.0 0.0 2.6 2 2 0 2 2 2 2 Aminotransferase class-V Pentapeptide PF00805.22 CDI81005.1 - 3.1e-51 170.5 20.2 0.025 14.2 0.0 22.7 8 6 8 21 21 21 17 Pentapeptide repeats (8 copies) Ribosomal_L2_C PF03947.18 CDI81007.1 - 1.2e-42 145.1 2.7 6e-42 142.8 3.0 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CDI81007.1 - 3.9e-18 65.2 0.1 1e-17 63.8 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Macoilin PF09726.9 CDI81009.1 - 0.24 9.9 2.6 0.56 8.7 2.6 1.6 1 0 0 1 1 1 0 Macoilin family Peptidase_S64 PF08192.11 CDI81009.1 - 0.39 9.1 1.8 0.52 8.7 1.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF202 PF02656.15 CDI81009.1 - 0.58 10.6 0.0 0.58 10.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF202) Apt1 PF10351.9 CDI81009.1 - 1.2 7.9 4.8 2 7.2 4.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAM2 PF07145.15 CDI81011.1 - 0.0011 18.5 0.5 0.0011 18.5 0.5 1.9 3 0 0 3 3 3 1 Ataxin-2 C-terminal region GET2 PF08690.10 CDI81011.1 - 0.033 13.8 1.7 0.031 13.9 1.7 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 SUIM_assoc PF16619.5 CDI81011.1 - 0.036 14.1 7.9 0.049 13.7 7.9 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI81011.1 - 0.27 10.8 9.5 0.3 10.7 9.5 1.1 1 0 0 1 1 1 0 Spt20 family Protamine_P2 PF00841.19 CDI81011.1 - 1.5 9.3 5.7 1.9 9.0 5.7 1.1 1 0 0 1 1 1 0 Sperm histone P2 AhpC-TSA PF00578.21 CDI81013.1 - 7.7e-30 103.4 0.0 9.6e-30 103.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDI81013.1 - 7.2e-12 45.2 0.0 8.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDI81013.1 - 5.9e-08 32.4 0.1 9.6e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 CDI81013.1 - 0.018 15.2 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme GSHPx PF00255.19 CDI81013.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Glutathione peroxidase RskA PF10099.9 CDI81014.1 - 0.0032 17.8 0.1 0.0032 17.8 0.1 4.0 3 1 0 4 4 4 2 Anti-sigma-K factor rskA Actin PF00022.19 CDI81015.1 - 1.6e-09 36.9 0.0 1.6e-09 36.9 0.0 3.2 3 1 0 3 3 3 1 Actin DUF2722 PF10846.8 CDI81015.1 - 0.00017 20.7 11.6 0.00017 20.7 11.6 3.6 3 1 1 4 4 4 1 Protein of unknown function (DUF2722) DDHD PF02862.17 CDI81015.1 - 0.019 15.2 0.6 0.019 15.2 0.6 4.4 3 1 0 3 3 3 0 DDHD domain CDC45 PF02724.14 CDI81015.1 - 0.29 9.4 35.4 0.063 11.6 21.2 2.3 2 0 0 2 2 2 0 CDC45-like protein GAGA_bind PF06217.12 CDI81015.1 - 1.3 9.3 31.6 3.1 8.0 5.8 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family PA26 PF04636.13 CDI81015.1 - 3.8 6.3 24.5 0.46 9.3 1.0 2.4 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) PRIMA1 PF16101.5 CDI81015.1 - 9.3 6.3 9.4 37 4.4 9.4 2.1 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RskA PF10099.9 CDI81017.1 - 4e-05 24.0 8.4 4e-05 24.0 8.4 7.6 3 2 3 6 6 6 3 Anti-sigma-K factor rskA Thioredoxin PF00085.20 CDI81018.1 - 2.7e-55 184.7 1.7 9.8e-31 105.8 0.3 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CDI81018.1 - 4.8e-28 98.3 5.6 1.6e-17 64.0 0.2 3.4 3 0 0 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 CDI81018.1 - 3.8e-14 52.7 0.4 2.5e-06 27.1 0.1 3.2 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 CDI81018.1 - 1.9e-11 43.6 0.7 4.2e-11 42.5 0.5 1.7 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_2 PF13098.6 CDI81018.1 - 2.3e-10 40.9 1.3 2.3e-05 24.8 0.1 3.1 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDI81018.1 - 7.3e-09 35.7 0.7 0.00042 20.4 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CDI81018.1 - 8.7e-09 35.6 0.1 0.0049 17.2 0.0 4.2 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 CDI81018.1 - 3.7e-08 33.3 0.4 5.8e-05 23.0 0.0 2.7 3 0 0 3 3 3 2 AhpC/TSA family TraF PF13728.6 CDI81018.1 - 1e-07 32.0 0.0 0.003 17.4 0.0 2.7 3 0 0 3 3 3 2 F plasmid transfer operon protein Redoxin PF08534.10 CDI81018.1 - 1e-05 25.3 0.3 0.0041 16.8 0.1 2.7 2 0 0 2 2 2 2 Redoxin Thioredoxin_9 PF14595.6 CDI81018.1 - 0.0022 17.8 0.1 3 7.6 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Glutaredoxin PF00462.24 CDI81018.1 - 0.0065 16.7 4.4 1.1 9.5 0.0 4.0 3 1 0 3 3 3 1 Glutaredoxin AAA_PrkA PF08298.11 CDI81018.1 - 0.046 12.6 0.0 0.1 11.5 0.0 1.6 1 0 0 1 1 1 0 PrkA AAA domain DUF2016 PF09436.10 CDI81018.1 - 0.076 12.8 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2016) DUF4107 PF13389.6 CDI81018.1 - 0.11 12.6 0.2 1.3 9.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4107) TFIIA PF03153.13 CDI81019.1 - 0.28 11.2 12.2 0.31 11.0 12.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LMBR1 PF04791.16 CDI81020.1 - 6.3 5.6 6.6 17 4.2 6.6 1.7 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4536 PF15055.6 CDI81022.1 - 0.0098 16.1 0.0 0.019 15.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4536) ETRAMP PF09716.10 CDI81023.1 - 2.1 8.4 6.5 3.7 7.7 0.0 4.4 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) CAF1 PF04857.20 CDI81023.1 - 8.1 5.5 16.0 5.8 6.0 4.1 3.3 3 0 0 3 3 3 0 CAF1 family ribonuclease RNA_Me_trans PF04252.13 CDI81024.1 - 2.2e-07 30.7 0.0 2.4e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase HWE_HK PF07536.14 CDI81024.1 - 0.017 15.8 0.0 0.019 15.6 0.0 1.1 1 0 0 1 1 1 0 HWE histidine kinase SSB PF00436.25 CDI81025.1 - 4.8e-32 110.1 0.1 7e-32 109.6 0.1 1.2 1 0 0 1 1 1 1 Single-strand binding protein family CW_binding_2 PF04122.12 CDI81025.1 - 0.13 12.9 6.1 0.98 10.1 3.7 2.5 2 0 0 2 2 2 0 Putative cell wall binding repeat 2 SUIM_assoc PF16619.5 CDI81026.1 - 0.0079 16.2 0.0 0.013 15.6 0.0 1.4 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Form-deh_trans PF09163.11 CDI81026.1 - 0.021 14.6 0.1 0.066 13.0 0.1 1.9 1 0 0 1 1 1 0 Formate dehydrogenase N, transmembrane Apc15p PF05841.11 CDI81026.1 - 0.1 13.4 3.8 0.16 12.7 3.8 1.3 1 0 0 1 1 1 0 Apc15p protein RskA PF10099.9 CDI81027.1 - 0.0064 16.8 0.0 0.0064 16.8 0.0 14.3 2 2 3 5 5 5 1 Anti-sigma-K factor rskA CLPTM1 PF05602.12 CDI81031.1 - 3.2e-45 154.9 3.8 2.6e-28 99.2 1.8 2.4 1 1 1 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) S1 PF00575.23 CDI81032.1 - 1.1e-12 48.1 0.1 1.4e-12 47.7 0.1 1.1 1 0 0 1 1 1 1 S1 RNA binding domain EcKinase PF02958.20 CDI81032.1 - 0.019 14.3 0.0 0.02 14.2 0.0 1.0 1 0 0 1 1 1 0 Ecdysteroid kinase EXOSC1 PF10447.9 CDI81032.1 - 0.083 13.5 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 Exosome component EXOSC1/CSL4 MutS_V PF00488.21 CDI81034.1 - 8.9e-18 65.0 0.1 3.7e-10 40.1 0.0 2.6 2 0 0 2 2 2 2 MutS domain V AAA_29 PF13555.6 CDI81034.1 - 0.0064 16.2 0.0 0.023 14.4 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDI81034.1 - 0.011 16.1 0.2 0.063 13.7 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CDI81034.1 - 0.012 16.1 1.3 0.073 13.6 1.3 2.2 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CDI81034.1 - 0.027 14.7 0.0 0.31 11.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CDI81034.1 - 0.03 14.1 0.1 0.085 12.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 CDI81034.1 - 0.032 13.4 0.1 0.056 12.6 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit AAA_23 PF13476.6 CDI81034.1 - 0.034 14.7 0.1 0.13 12.8 0.1 2.1 1 1 0 1 1 1 0 AAA domain DUF1177 PF06675.11 CDI81034.1 - 0.079 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1177) SMC_N PF02463.19 CDI81034.1 - 0.089 12.2 0.2 0.18 11.2 0.2 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain PPV_E1_C PF00519.17 CDI81034.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_33 PF13671.6 CDI81034.1 - 0.14 12.3 0.9 3.9 7.6 0.3 2.5 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDI81034.1 - 0.19 11.7 0.6 2.3 8.2 0.6 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 CDI81034.1 - 0.25 11.0 2.6 1.3 8.7 2.6 2.2 1 1 0 1 1 1 0 AAA ATPase domain TPR_16 PF13432.6 CDI81035.1 - 3.3e-05 24.4 3.9 3.3e-05 24.4 3.9 11.5 10 1 1 11 11 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDI81035.1 - 9.7e-05 22.8 0.2 9.7e-05 22.8 0.2 11.7 8 3 5 13 13 11 6 Tetratricopeptide repeat NAM-associated PF14303.6 CDI81035.1 - 0.0007 20.4 0.0 0.0007 20.4 0.0 5.4 5 2 1 6 6 5 1 No apical meristem-associated C-terminal domain TPR_9 PF13371.6 CDI81035.1 - 0.0014 18.7 0.4 0.0014 18.7 0.4 10.3 7 1 3 10 10 10 1 Tetratricopeptide repeat SDA1 PF05285.12 CDI81035.1 - 0.0049 16.4 10.6 0.0059 16.1 5.7 2.6 2 0 0 2 2 2 1 SDA1 TPR_1 PF00515.28 CDI81035.1 - 0.014 15.2 29.9 1 9.3 0.0 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI81035.1 - 0.015 16.0 2.3 0.015 16.0 2.3 15.7 12 3 4 16 16 15 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDI81035.1 - 0.085 13.0 0.1 0.085 13.0 0.1 12.7 13 0 0 13 13 13 0 Tetratricopeptide repeat DUF4919 PF16266.5 CDI81035.1 - 0.16 11.9 0.8 0.5 10.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) TPR_8 PF13181.6 CDI81035.1 - 0.38 11.1 36.2 2.7 8.4 0.5 9.7 11 0 0 11 11 11 0 Tetratricopeptide repeat DUF2150 PF09920.9 CDI81035.1 - 0.43 10.5 10.8 0.27 11.2 2.4 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2150) DUF2076 PF09849.9 CDI81040.1 - 0.00028 21.0 8.6 0.00028 21.0 8.6 8.2 3 2 2 5 5 5 1 Uncharacterized protein conserved in bacteria (DUF2076) RskA PF10099.9 CDI81040.1 - 0.00059 20.2 9.8 0.00059 20.2 9.8 8.1 3 3 3 6 6 6 1 Anti-sigma-K factor rskA Hist_deacetyl PF00850.19 CDI81040.1 - 0.0077 15.7 1.7 0.0077 15.7 1.7 4.9 3 2 0 3 3 3 1 Histone deacetylase domain SpoIIP PF07454.11 CDI81040.1 - 0.01 15.3 2.2 0.01 15.3 2.2 7.1 4 3 1 5 5 5 0 Stage II sporulation protein P (SpoIIP) DUF4834 PF16118.5 CDI81040.1 - 0.023 15.7 4.6 0.023 15.7 4.6 8.8 5 2 1 6 6 6 0 Domain of unknown function (DUF4834) PCI PF01399.27 CDI81042.1 - 0.012 16.1 0.0 4.4 7.9 0.0 2.3 2 0 0 2 2 2 0 PCI domain tRNA-synt_2d PF01409.20 CDI81044.1 - 6.2e-77 258.4 0.0 7.1e-77 258.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 CDI81044.1 - 7e-08 32.2 0.0 6e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 CDI81044.1 - 0.00014 21.0 0.1 0.00022 20.4 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) OapA PF04225.12 CDI81044.1 - 0.14 12.3 0.1 0.36 11.0 0.0 1.7 2 0 0 2 2 2 0 Opacity-associated protein A LysM-like domain ING PF12998.7 CDI81048.1 - 5e-07 30.2 2.3 5e-07 30.2 2.3 2.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding SUIM_assoc PF16619.5 CDI81048.1 - 0.034 14.2 0.5 0.034 14.2 0.5 6.2 3 1 2 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 LMBR1 PF04791.16 CDI81048.1 - 0.45 9.4 6.3 0.54 9.1 6.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Flu_PB1 PF00602.17 CDI81048.1 - 0.66 8.0 2.7 0.95 7.5 2.7 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Stn1 PF10451.9 CDI81048.1 - 2 7.3 7.1 3.3 6.6 7.1 1.3 1 0 0 1 1 1 0 Telomere regulation protein Stn1 CoA_binding PF02629.19 CDI81049.1 - 7.5e-20 71.4 0.0 1.9e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 CDI81049.1 - 5e-10 39.4 0.1 9.7e-08 32.0 0.0 2.2 1 1 1 2 2 2 2 CoA-ligase Succ_CoA_lig PF13607.6 CDI81049.1 - 4.9e-05 23.1 0.3 0.00029 20.6 0.0 2.1 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CDI81049.1 - 0.0011 19.4 0.4 0.0056 17.2 0.0 2.1 3 0 0 3 3 3 1 CoA binding domain LpxD PF04613.14 CDI81049.1 - 0.17 11.7 1.0 0.88 9.4 0.2 2.1 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD MAM PF00629.23 CDI81051.1 - 9.3e-11 41.9 14.1 1.5e-05 24.9 0.0 3.6 2 1 1 3 3 2 2 MAM domain, meprin/A5/mu SR-25 PF10500.9 CDI81051.1 - 0.011 15.3 22.8 0.025 14.2 22.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ndc1_Nup PF09531.10 CDI81051.1 - 0.05 12.3 16.9 0.084 11.5 16.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PI3K_1B_p101 PF10486.9 CDI81051.1 - 0.54 8.0 18.9 0.76 7.5 18.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1635 PF07795.11 CDI81051.1 - 2.6 7.8 21.7 5.7 6.7 21.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF966 PF06136.13 CDI81051.1 - 3.1 7.4 21.6 6.6 6.3 21.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF5427 PF10310.9 CDI81051.1 - 3.8 6.3 24.6 6.4 5.6 24.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DNA_methylase PF00145.17 CDI81051.1 - 3.9 6.7 12.9 6.6 6.0 12.9 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Presenilin PF01080.17 CDI81051.1 - 7.5 5.2 25.8 12 4.6 25.8 1.2 1 0 0 1 1 1 0 Presenilin SURF2 PF05477.11 CDI81051.1 - 8 6.1 19.5 13 5.4 19.5 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CDK2AP PF09806.9 CDI81051.1 - 8.2 6.4 32.0 8.8 6.3 25.9 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein GREB1 PF15782.5 CDI81051.1 - 9.1 3.2 22.9 13 2.7 22.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF5523 PF17661.1 CDI81053.1 - 0.0054 16.4 4.2 0.0054 16.4 4.2 1.8 2 0 0 2 2 1 1 Family of unknown function (DUF5523) DUF4667 PF15700.5 CDI81053.1 - 0.012 15.7 44.2 0.11 12.5 1.2 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4667) SUIM_assoc PF16619.5 CDI81053.1 - 0.035 14.2 0.2 0.035 14.2 0.2 5.5 3 1 1 4 4 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2370 PF10176.9 CDI81053.1 - 0.65 9.6 4.7 2 8.0 4.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) PAT1 PF09770.9 CDI81053.1 - 1.4 7.1 27.3 0.66 8.2 20.4 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SpoVR PF04293.13 CDI81053.1 - 1.7 7.2 9.4 3.3 6.3 9.4 1.3 1 0 0 1 1 1 0 SpoVR like protein Peptidase_U57 PF05582.12 CDI81053.1 - 2.1 7.6 6.1 4.2 6.5 6.1 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Ribosomal_L6e PF01159.19 CDI81053.1 - 2.3 8.8 11.1 7 7.2 11.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L6e DUF4746 PF15928.5 CDI81053.1 - 4.7 6.5 5.2 9.4 5.6 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 CDI81053.1 - 5.1 4.9 12.0 11 3.8 12.0 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI81053.1 - 5.5 5.9 19.3 0.76 8.7 14.7 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AP2 PF00847.20 CDI81054.1 - 3.3e-13 49.6 4.8 1.1e-12 48.0 4.8 1.9 1 0 0 1 1 1 1 AP2 domain Isy1 PF06246.12 CDI81056.1 - 5.1e-65 219.6 3.4 6.1e-65 219.3 3.4 1.1 1 0 0 1 1 1 1 Isy1-like splicing family Hexokinase_2 PF03727.16 CDI81056.1 - 0.014 14.8 0.5 0.022 14.2 0.5 1.3 1 0 0 1 1 1 0 Hexokinase BAF1_ABF1 PF04684.13 CDI81056.1 - 0.062 12.4 1.6 0.065 12.3 1.6 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MPM1 PF17234.2 CDI81056.1 - 0.12 12.6 1.0 0.18 12.0 1.0 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 ASFV_J13L PF05568.11 CDI81056.1 - 1.8 8.3 9.9 2.8 7.6 9.9 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DEAD PF00270.29 CDI81059.1 - 4.2e-21 75.5 2.5 3.6e-13 49.6 0.3 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI81059.1 - 3.6e-18 65.9 2.4 1.5e-17 64.0 0.0 3.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDI81059.1 - 3.4e-14 52.8 0.1 7.2e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Shadoo PF14999.6 CDI81059.1 - 0.012 15.7 9.3 0.012 15.7 9.3 6.3 5 1 1 6 6 6 0 Shadow of prion protein, neuroprotective T4SS-DNA_transf PF02534.14 CDI81059.1 - 0.037 12.8 1.1 0.089 11.6 0.0 2.0 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer AAA_22 PF13401.6 CDI81059.1 - 0.051 13.8 0.1 2.5 8.4 0.1 3.1 2 0 0 2 2 2 0 AAA domain Spc7_N PF15402.6 CDI81062.1 - 1.7 6.8 26.5 2.6 6.2 26.5 1.2 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Presenilin PF01080.17 CDI81062.1 - 6.3 5.4 25.9 8.3 5.1 25.9 1.4 1 0 0 1 1 1 0 Presenilin SAGA-Tad1 PF12767.7 CDI81062.1 - 6.5 6.4 21.1 7.9 6.1 21.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit vATP-synt_AC39 PF01992.16 CDI81063.1 - 6.8e-28 98.1 0.3 3.2e-27 95.9 0.3 1.8 1 1 0 1 1 1 1 ATP synthase (C/AC39) subunit Spt20 PF12090.8 CDI81063.1 - 0.0086 15.7 10.4 0.15 11.7 6.3 2.2 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI81063.1 - 0.0092 16.3 9.5 0.0092 16.3 9.5 2.3 2 1 0 2 2 2 1 Anti-sigma-K factor rskA Archease PF01951.16 CDI81063.1 - 0.069 13.4 1.3 0.12 12.6 1.3 1.4 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) SUIM_assoc PF16619.5 CDI81063.1 - 0.21 11.7 23.5 0.06 13.4 8.4 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TetR_C_28 PF17937.1 CDI81063.1 - 0.43 11.1 9.3 0.08 13.4 5.4 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain SR-25 PF10500.9 CDI81064.1 - 0.022 14.4 5.8 0.027 14.1 5.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spem1 PF15670.5 CDI81064.1 - 0.031 13.9 0.2 0.036 13.7 0.2 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 ALC PF17527.2 CDI81064.1 - 0.12 12.0 7.4 0.16 11.6 7.4 1.1 1 0 0 1 1 1 0 Phage ALC protein ETRAMP PF09716.10 CDI81064.1 - 7.4 6.7 7.7 12 6.0 7.7 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Presenilin PF01080.17 CDI81065.1 - 0.0052 15.6 20.0 0.0061 15.4 20.0 1.2 1 0 0 1 1 1 1 Presenilin Caldesmon PF02029.15 CDI81065.1 - 0.013 14.3 25.4 0.018 13.8 25.4 1.2 1 0 0 1 1 1 0 Caldesmon Lin-8 PF03353.15 CDI81065.1 - 0.057 13.0 22.8 0.079 12.5 22.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist V_ATPase_I PF01496.19 CDI81065.1 - 0.096 10.6 16.7 0.12 10.2 16.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 CDI81065.1 - 0.16 10.2 25.2 0.23 9.7 25.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4175 PF13779.6 CDI81065.1 - 0.18 9.7 33.7 0.2 9.5 33.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) GREB1 PF15782.5 CDI81065.1 - 0.48 7.5 16.8 0.47 7.5 16.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI81065.1 - 1.3 7.2 32.8 1.5 7.0 32.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dsh_C PF12316.8 CDI81065.1 - 3.6 8.0 14.0 1.2 9.5 10.9 1.7 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Hid1 PF12722.7 CDI81065.1 - 4.6 5.2 22.1 6.2 4.8 22.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Apc15p PF05841.11 CDI81065.1 - 9.5 7.1 31.2 0.14 12.9 14.9 2.5 1 1 1 2 2 2 0 Apc15p protein CRAL_TRIO PF00650.20 CDI81067.1 - 5e-26 91.3 0.0 7.1e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Coprogen_oxidas PF01218.18 CDI81075.1 - 4.7e-100 334.1 0.0 8.8e-87 290.6 0.0 2.2 2 0 0 2 2 2 2 Coproporphyrinogen III oxidase K_channel_TID PF07941.11 CDI81075.1 - 0.0057 17.1 7.1 0.0057 17.1 7.1 3.0 3 0 0 3 3 3 1 Potassium channel Kv1.4 tandem inactivation domain Plasmodium_Vir PF05795.11 CDI81075.1 - 0.067 12.6 0.2 0.11 11.9 0.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF853 PF05872.12 CDI81075.1 - 0.21 10.1 0.5 0.35 9.4 0.5 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF4770 PF15994.5 CDI81076.1 - 3.3 7.9 16.1 0.12 12.6 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Ndc1_Nup PF09531.10 CDI81076.1 - 9.2 4.8 17.3 18 3.8 17.3 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 CDI81078.1 - 0.025 14.6 31.1 0.04 13.9 31.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI81078.1 - 0.57 10.6 9.9 0.86 10.1 9.9 1.4 1 0 0 1 1 1 0 AAA domain Macoilin PF09726.9 CDI81078.1 - 1.5 7.3 21.2 2.4 6.6 21.2 1.2 1 0 0 1 1 1 0 Macoilin family Adaptin_binding PF10199.9 CDI81082.1 - 1.7e-06 28.6 1.4 1.7e-06 28.6 1.4 3.5 1 1 1 2 2 2 1 Alpha and gamma adaptin binding protein p34 Spt20 PF12090.8 CDI81082.1 - 0.21 11.2 25.7 0.061 12.9 6.6 3.2 3 0 0 3 3 3 0 Spt20 family tRNA-synt_2d PF01409.20 CDI81083.1 - 2.7e-31 108.9 0.5 1.3e-12 47.8 0.2 4.1 4 0 0 4 4 4 3 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 CDI81083.1 - 3.8e-16 59.3 0.1 3.8e-16 59.3 0.1 2.9 2 1 0 2 2 2 1 Ferredoxin-fold anticodon binding domain NAM-associated PF14303.6 CDI81083.1 - 0.0017 19.1 0.0 0.0017 19.1 0.0 6.9 7 2 0 7 7 7 1 No apical meristem-associated C-terminal domain DUF4667 PF15700.5 CDI81083.1 - 0.0097 16.0 3.4 0.0097 16.0 3.4 5.2 3 1 1 4 4 4 1 Domain of unknown function (DUF4667) SPX PF03105.19 CDI81083.1 - 0.018 15.0 55.0 0.019 14.9 1.8 4.0 4 0 0 4 4 4 0 SPX domain DUF3188 PF11384.8 CDI81083.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) TCP PF03634.13 CDI81083.1 - 3.2 8.3 50.5 0.47 11.0 2.3 5.6 5 0 0 5 5 5 0 TCP family transcription factor EELM2 PF15863.5 CDI81084.1 - 3.3e-15 56.6 0.0 2.2e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 Extended EGL-27 and MTA1 homology domain Spt20 PF12090.8 CDI81086.1 - 0.0009 18.9 10.0 0.0009 18.9 10.0 2.4 2 0 0 2 2 2 1 Spt20 family Ecl1 PF12855.7 CDI81086.1 - 0.64 11.2 30.2 3.5 8.8 0.1 3.2 3 0 0 3 3 3 0 ECL1/2/3 zinc binding proteins Spore_coat_CotO PF14153.6 CDI81086.1 - 1.5 8.7 13.1 0.025 14.5 1.8 2.4 2 0 0 2 2 2 0 Spore coat protein CotO EPL1 PF10513.9 CDI81086.1 - 2.1 8.7 13.0 13 6.2 4.3 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like USP8_interact PF08941.10 CDI81086.1 - 3.9 7.2 8.6 7.1 6.4 8.6 1.3 1 0 0 1 1 1 0 USP8 interacting Pkinase PF00069.25 CDI81087.1 - 6.4e-78 261.8 0.0 9.8e-78 261.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI81087.1 - 6.1e-34 117.5 0.0 1.2e-33 116.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase EF-hand_1 PF00036.32 CDI81087.1 - 2.8e-28 95.3 9.8 1.8e-07 30.2 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CDI81087.1 - 9.1e-25 84.4 5.9 1.1e-06 28.1 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 CDI81087.1 - 3.3e-24 85.1 4.5 1.4e-12 47.9 1.7 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CDI81087.1 - 2.6e-22 77.3 10.3 4.6e-08 32.2 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CDI81087.1 - 9.6e-21 73.4 13.2 1.2e-10 41.1 4.7 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 CDI81087.1 - 1.1e-07 31.7 0.7 0.0033 17.4 0.2 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CDI81087.1 - 1.7e-07 31.5 1.1 0.0027 18.0 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain Kinase-like PF14531.6 CDI81087.1 - 3.5e-05 23.2 0.0 0.00099 18.5 0.0 2.3 1 1 1 2 2 2 1 Kinase-like SPARC_Ca_bdg PF10591.9 CDI81087.1 - 0.00023 21.5 0.4 0.57 10.5 0.2 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region ABC1 PF03109.16 CDI81087.1 - 0.011 15.9 0.1 0.062 13.5 0.0 2.1 2 0 0 2 2 2 0 ABC1 family APH PF01636.23 CDI81087.1 - 0.094 12.6 0.0 0.25 11.2 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDI81087.1 - 0.1 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase VCBS PF13517.6 CDI81087.1 - 0.13 12.9 0.7 13 6.5 0.1 2.9 3 0 0 3 3 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF1103 PF06513.11 CDI81087.1 - 0.32 10.6 1.1 0.51 9.9 1.1 1.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Dockerin_1 PF00404.18 CDI81087.1 - 6.8 7.0 6.6 25 5.2 1.2 3.4 1 1 1 2 2 2 0 Dockerin type I domain Xpo1 PF08389.12 CDI81088.1 - 0.012 15.6 0.1 0.15 12.1 0.0 2.6 2 1 1 3 3 3 0 Exportin 1-like protein IBN_N PF03810.19 CDI81088.1 - 0.027 14.4 0.3 0.081 12.8 0.3 1.8 1 0 0 1 1 1 0 Importin-beta N-terminal domain FeS_assembly_P PF01883.19 CDI81092.1 - 0.013 15.6 0.0 6.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Iron-sulfur cluster assembly protein Euplotes_phero PF05842.11 CDI81092.1 - 0.022 15.3 3.8 0.12 12.9 0.9 2.2 2 0 0 2 2 2 0 Euplotes octocarinatus mating pheromone protein Cwf_Cwc_15 PF04889.12 CDI81098.1 - 3.4 7.3 39.6 4.1 7.1 39.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2353 PF09789.9 CDI81101.1 - 0.16 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Pep3_Vps18 PF05131.14 CDI81104.1 - 1.3e-06 28.3 0.0 4e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family RskA PF10099.9 CDI81106.1 - 0.00088 19.6 1.3 0.00088 19.6 1.3 20.1 2 1 14 16 16 16 2 Anti-sigma-K factor rskA Ku PF02735.16 CDI81108.1 - 3.6e-19 69.3 0.0 9.2e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 CDI81108.1 - 1.1e-15 57.8 3.3 6.4e-05 23.1 0.1 4.0 3 0 0 3 3 3 3 Ku C terminal domain like Activator_LAG-3 PF11498.8 CDI81108.1 - 0.0025 16.9 3.4 0.0025 16.9 3.4 5.4 5 0 0 5 5 5 2 Transcriptional activator LAG-3 Spt20 PF12090.8 CDI81108.1 - 0.0033 17.1 11.6 0.0033 17.1 11.6 5.4 5 1 0 5 5 5 3 Spt20 family DUF2722 PF10846.8 CDI81108.1 - 0.0052 15.8 5.5 0.0052 15.8 5.5 5.9 4 2 1 5 5 5 1 Protein of unknown function (DUF2722) RskA PF10099.9 CDI81108.1 - 0.0087 16.4 20.7 0.0087 16.4 20.7 8.2 4 2 2 6 6 6 3 Anti-sigma-K factor rskA Miff PF05644.11 CDI81109.1 - 0.046 13.3 6.3 0.055 13.1 6.3 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Spt20 PF12090.8 CDI81109.1 - 0.09 12.4 18.3 0.12 12.0 18.3 1.2 1 0 0 1 1 1 0 Spt20 family DUF3464 PF11947.8 CDI81109.1 - 0.17 11.6 2.7 0.25 11.1 2.7 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 EIF4E-T PF10477.9 CDI81109.1 - 0.17 10.7 9.5 0.18 10.6 9.5 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF2126 PF09899.9 CDI81109.1 - 0.28 9.2 4.4 0.28 9.2 4.4 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4834 PF16118.5 CDI81109.1 - 0.79 10.7 4.0 1.3 10.1 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 CDI81109.1 - 0.89 9.5 27.9 1 9.3 27.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RIFIN PF02009.16 CDI81109.1 - 0.94 9.3 8.7 1.1 9.1 8.7 1.1 1 0 0 1 1 1 0 Rifin USP8_interact PF08941.10 CDI81109.1 - 1 9.1 6.6 1.2 8.9 6.6 1.1 1 0 0 1 1 1 0 USP8 interacting DUF702 PF05142.12 CDI81109.1 - 1.4 9.4 9.2 2.2 8.8 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Rtf2 PF04641.12 CDI81109.1 - 1.8 7.9 10.0 2.2 7.6 10.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger TERB2 PF15101.6 CDI81109.1 - 1.8 8.6 8.8 2.3 8.2 8.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Neur_chan_memb PF02932.16 CDI81109.1 - 2.4 8.2 4.6 2.5 8.1 4.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sin_N PF04801.13 CDI81109.1 - 3.6 6.7 14.2 4.7 6.3 14.2 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region DUF775 PF05603.12 CDI81109.1 - 3.9 6.9 13.9 5.1 6.6 13.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF775) Presenilin PF01080.17 CDI81109.1 - 4.7 5.9 8.4 4.4 6.0 8.4 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDI81109.1 - 5.5 6.0 7.1 5.5 6.0 7.1 1.1 1 0 0 1 1 1 0 Drosophila roughex protein CDK2AP PF09806.9 CDI81109.1 - 6.7 6.7 22.5 2 8.4 19.7 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Hid1 PF12722.7 CDI81109.1 - 9.6 4.2 8.0 9 4.3 8.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein EPSP_synthase PF00275.20 CDI81110.1 - 2.3e-31 108.9 7.0 2.7e-06 26.3 0.0 8.4 8 1 1 9 9 9 6 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 CDI81110.1 - 7.4e-23 81.0 0.1 7.4e-23 81.0 0.1 3.1 3 0 0 3 3 3 1 3-dehydroquinate synthase SPX PF03105.19 CDI81110.1 - 5e-09 36.6 80.1 0.0025 17.8 0.7 4.6 4 0 0 4 4 4 4 SPX domain Apt1 PF10351.9 CDI81110.1 - 0.5 9.2 0.0 0.5 9.2 0.0 6.8 4 3 0 5 5 5 0 Golgi-body localisation protein domain OTCace PF00185.24 CDI81111.1 - 4.6e-06 26.8 0.0 4.6e-06 26.8 0.0 4.5 3 2 1 4 4 4 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain DUF1635 PF07795.11 CDI81111.1 - 0.00052 20.0 13.1 0.00052 20.0 13.1 7.9 1 1 6 8 8 8 1 Protein of unknown function (DUF1635) ABC_membrane PF00664.23 CDI81112.1 - 2.1e-21 76.8 1.5 2.8e-21 76.4 0.6 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDI81112.1 - 5.1e-19 69.2 1.0 1.5e-18 67.6 0.0 2.4 3 0 0 3 3 2 1 ABC transporter SbcCD_C PF13558.6 CDI81112.1 - 6.3e-06 26.3 0.2 2.7e-05 24.3 0.2 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 CDI81112.1 - 0.0006 20.2 0.1 0.0006 20.2 0.1 3.5 4 0 0 4 4 4 1 AAA ATPase domain Spt20 PF12090.8 CDI81112.1 - 0.0022 17.6 17.5 0.0081 15.8 5.2 2.3 2 0 0 2 2 2 2 Spt20 family Androgen_recep PF02166.16 CDI81112.1 - 0.006 15.5 3.5 0.006 15.5 3.5 4.2 4 1 1 5 5 4 1 Androgen receptor AAA_29 PF13555.6 CDI81112.1 - 0.0063 16.2 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain TFIIA PF03153.13 CDI81112.1 - 0.0082 16.2 14.0 0.07 13.1 2.7 2.4 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI81112.1 - 0.018 14.0 9.4 0.016 14.1 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) AAA_21 PF13304.6 CDI81112.1 - 0.028 14.2 0.2 0.17 11.6 0.0 2.2 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CDI81112.1 - 0.046 14.0 0.1 0.41 10.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDI81112.1 - 0.19 12.3 0.0 0.52 10.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_23 PF13476.6 CDI81112.1 - 6.6 7.2 10.9 2.6 8.5 0.0 2.7 3 0 0 3 3 2 0 AAA domain Pex14_N PF04695.13 CDI81112.1 - 9 6.9 16.1 8.8 7.0 3.8 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDRGK PF09756.9 CDI81114.1 - 2.9e-40 137.9 18.3 2.9e-40 137.9 18.3 2.2 1 1 1 2 2 2 1 DDRGK domain RskA PF10099.9 CDI81114.1 - 0.018 15.3 12.9 0.029 14.7 12.9 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA ADP_ribosyl_GH PF03747.14 CDI81114.1 - 0.52 10.0 8.3 0.99 9.1 8.3 1.4 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase TFIIA PF03153.13 CDI81114.1 - 0.68 9.9 12.8 0.85 9.5 12.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BAF1_ABF1 PF04684.13 CDI81114.1 - 1.4 7.9 13.3 2.2 7.2 13.3 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CCDC71L PF15374.6 CDI81114.1 - 4.6 6.4 14.0 6.4 5.9 14.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L RXLR PF16810.5 CDI81114.1 - 7.2 7.0 16.1 2.2 8.7 12.3 2.1 1 1 1 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity Rpp20 PF12328.8 CDI81115.1 - 0.0063 16.5 0.4 0.0063 16.5 0.4 1.8 2 0 0 2 2 2 1 Rpp20 subunit of nuclear RNase MRP and P Abhydrolase_1 PF00561.20 CDI81115.1 - 0.026 14.2 0.0 0.16 11.6 0.0 2.1 2 1 0 2 2 2 0 alpha/beta hydrolase fold Methyltransf_34 PF11312.8 CDI81115.1 - 0.028 13.7 3.2 0.078 12.2 3.2 1.8 1 1 0 1 1 1 0 Putative SAM-dependent methyltransferase MecA PF05389.12 CDI81115.1 - 0.044 13.4 2.8 4.2 6.9 1.3 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) GMC_oxred_C PF05199.13 CDI81115.1 - 0.066 13.7 1.3 0.87 10.1 0.1 2.3 2 0 0 2 2 2 0 GMC oxidoreductase FHIPEP PF00771.20 CDI81115.1 - 0.094 11.2 1.3 0.62 8.5 0.1 2.0 2 0 0 2 2 2 0 FHIPEP family INSIG PF07281.12 CDI81115.1 - 0.2 11.3 1.3 0.44 10.2 0.1 2.1 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) Tau95_N PF17682.1 CDI81115.1 - 1.8 8.8 4.7 0.36 11.0 0.8 1.7 2 0 0 2 2 2 0 Tau95 Triple barrel domain Dfp1_Him1_M PF08630.10 CDI81115.1 - 3.4 7.9 8.0 2.1 8.6 1.3 2.3 2 0 0 2 2 2 0 Dfp1/Him1, central region Calc_CGRP_IAPP PF00214.19 CDI81115.1 - 3.5 8.0 13.8 4.1 7.8 0.8 3.0 3 0 0 3 3 3 0 Calcitonin / CGRP / IAPP family Suf PF05843.14 CDI81115.1 - 4.7 7.1 13.2 0.045 13.7 2.9 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Pet20 PF08692.10 CDI81122.1 - 0.082 13.6 0.1 0.082 13.6 0.1 3.4 1 1 2 3 3 3 0 Mitochondrial protein Pet20 BAF1_ABF1 PF04684.13 CDI81122.1 - 6.2 5.8 50.2 0.27 10.2 35.9 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Thioredoxin PF00085.20 CDI81123.1 - 1e-12 47.9 0.0 1.2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 CDI81123.1 - 0.001 18.8 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 CDI81123.1 - 0.0068 16.1 0.9 0.014 15.1 0.4 1.7 1 1 1 2 2 2 1 Redoxin Thioredoxin_8 PF13905.6 CDI81123.1 - 0.06 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like GREB1 PF15782.5 CDI81124.1 - 5.8e-05 20.5 21.9 7.2e-05 20.2 21.9 1.1 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDI81124.1 - 0.00016 21.8 69.4 0.00021 21.4 69.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PTPRCAP PF15713.5 CDI81124.1 - 0.0034 17.7 28.1 0.0034 17.7 28.1 2.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated Smg8_Smg9 PF10220.9 CDI81124.1 - 0.02 13.2 24.8 0.0055 15.1 20.3 1.9 2 0 0 2 2 2 0 Smg8_Smg9 LMBR1 PF04791.16 CDI81124.1 - 0.028 13.4 13.5 0.038 12.9 13.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Hist_deacetyl PF00850.19 CDI81124.1 - 0.11 11.9 0.1 0.11 11.9 0.1 2.3 2 0 0 2 2 2 0 Histone deacetylase domain BAF1_ABF1 PF04684.13 CDI81124.1 - 0.15 11.1 30.5 0.16 11.0 22.6 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Mem_trans PF03547.18 CDI81124.1 - 1.6 7.1 7.6 2.9 6.2 7.6 1.4 1 0 0 1 1 1 0 Membrane transport protein Mitofilin PF09731.9 CDI81124.1 - 1.8 7.3 41.8 1.1 8.0 30.1 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein CDC45 PF02724.14 CDI81124.1 - 2.1 6.5 37.9 0.02 13.2 30.2 1.4 2 0 0 2 2 2 0 CDC45-like protein DUF853 PF05872.12 CDI81124.1 - 2.5 6.6 20.7 4.8 5.6 20.7 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) MCM_bind PF09739.9 CDI81124.1 - 2.7 6.3 34.9 0.027 12.9 27.2 1.5 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor FAM60A PF15396.6 CDI81124.1 - 3.1 7.8 30.1 0.15 12.0 23.3 1.9 2 0 0 2 2 2 0 Protein Family FAM60A CLN3 PF02487.17 CDI81124.1 - 7.4 5.5 25.7 0.15 11.1 18.5 1.7 2 0 0 2 2 2 0 CLN3 protein DUF4746 PF15928.5 CDI81124.1 - 7.9 5.8 31.1 0.3 10.5 21.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) AAA_23 PF13476.6 CDI81128.1 - 0.015 15.8 19.1 0.13 12.7 8.1 2.4 2 0 0 2 2 2 0 AAA domain cwf18 PF08315.12 CDI81128.1 - 0.045 14.4 10.1 0.12 13.1 3.0 2.5 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor ArsA_HSP20 PF17886.1 CDI81128.1 - 0.082 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 HSP20-like domain found in ArsA SET PF00856.28 CDI81128.1 - 0.13 12.6 6.9 0.16 12.3 0.5 2.4 2 1 0 2 2 2 0 SET domain Cob_adeno_trans PF01923.18 CDI81128.1 - 0.29 11.3 8.2 0.11 12.6 1.8 2.2 2 0 0 2 2 2 0 Cobalamin adenosyltransferase DUF1645 PF07816.11 CDI81128.1 - 0.66 10.5 10.2 0.12 12.9 1.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1645) TERB2 PF15101.6 CDI81128.1 - 0.96 9.5 25.4 0.17 12.0 8.3 2.8 3 0 0 3 3 3 0 Telomere-associated protein TERB2 ABC2_membrane_3 PF12698.7 CDI81128.1 - 1.8 7.6 11.0 2.1 7.4 1.4 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein GvpL_GvpF PF06386.11 CDI81128.1 - 4.7 7.1 13.7 1.7 8.5 5.4 2.4 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Peptidase_S49_N PF08496.10 CDI81128.1 - 4.7 7.3 15.3 3 7.9 6.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RskA PF10099.9 CDI81128.1 - 5.6 7.2 12.6 0.71 10.1 1.1 2.9 3 0 0 3 3 3 0 Anti-sigma-K factor rskA CPSF100_C PF13299.6 CDI81128.1 - 5.6 7.1 10.0 3.7 7.7 3.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Thg1C PF14413.6 CDI81128.1 - 5.9 7.1 13.6 3.4 7.9 0.4 2.5 2 0 0 2 2 2 0 Thg1 C terminal domain Pro_CA PF00484.19 CDI81128.1 - 6.5 7.0 8.3 0.75 10.1 1.5 2.1 2 0 0 2 2 2 0 Carbonic anhydrase Bestrophin PF01062.21 CDI81128.1 - 9.4 5.5 10.2 8.3 5.7 0.5 2.1 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel Suf PF05843.14 CDI81128.1 - 9.9 6.0 26.8 0.27 11.2 6.9 2.5 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Collagen PF01391.18 CDI81134.1 - 0.00039 20.1 34.0 0.00039 20.1 34.0 2.5 2 1 0 2 2 2 1 Collagen triple helix repeat (20 copies) DUF2722 PF10846.8 CDI81134.1 - 0.0015 17.5 16.0 0.0015 17.5 16.0 5.2 3 1 2 5 5 5 2 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI81134.1 - 0.0016 18.6 20.1 0.0016 18.6 20.1 3.4 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit NAM-associated PF14303.6 CDI81136.1 - 0.012 16.3 2.2 0.012 16.3 2.2 7.6 5 3 2 7 7 7 0 No apical meristem-associated C-terminal domain Sof1 PF04158.14 CDI81138.1 - 1.2e-29 102.3 14.0 1.7e-29 101.9 14.0 1.2 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 CDI81138.1 - 4.8e-09 36.7 5.9 0.0027 18.5 0.2 4.4 5 1 1 6 6 6 3 WD domain, G-beta repeat Glt_symporter PF03616.14 CDI81139.1 - 0.0049 15.6 0.3 0.0049 15.6 0.3 2.0 1 1 1 2 2 2 1 Sodium/glutamate symporter CCSAP PF15748.5 CDI81141.1 - 0.079 13.1 23.2 0.097 12.8 23.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF5523 PF17661.1 CDI81141.1 - 0.15 11.7 15.1 0.19 11.4 15.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) eIF-3_zeta PF05091.12 CDI81141.1 - 0.43 9.5 20.4 0.5 9.3 20.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Dsh_C PF12316.8 CDI81141.1 - 1 9.7 17.5 1.2 9.5 17.5 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Cellulose_synt PF03552.14 CDI81141.1 - 1.3 7.4 9.0 1.6 7.1 9.0 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF4175 PF13779.6 CDI81141.1 - 1.4 6.7 46.4 1.5 6.6 46.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TFIIA PF03153.13 CDI81141.1 - 2.2 8.2 51.3 3.1 7.7 51.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI81141.1 - 3 7.3 20.0 3.2 7.2 20.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit SR-25 PF10500.9 CDI81141.1 - 3.3 7.3 28.6 12 5.4 28.6 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Lin-8 PF03353.15 CDI81141.1 - 4 6.9 24.0 5.7 6.4 24.0 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Spc7_N PF15402.6 CDI81141.1 - 4.4 5.4 21.2 6.9 4.8 21.2 1.3 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 ALMT PF11744.8 CDI81141.1 - 5.5 5.7 16.8 6.4 5.5 16.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 CDI81141.1 - 5.7 6.7 19.3 6.6 6.5 19.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MRP-S26 PF14943.6 CDI81141.1 - 6.3 6.7 18.8 7.6 6.4 18.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SLC12 PF03522.15 CDI81141.1 - 7.2 5.5 21.3 8.7 5.2 21.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 CDI81141.1 - 7.2 5.4 20.0 8.3 5.2 20.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 CDI81141.1 - 7.3 5.2 25.2 9.2 4.9 25.2 1.1 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 CDI81141.1 - 8.6 6.2 23.7 12 5.8 23.7 1.2 1 0 0 1 1 1 0 Velvet factor Bac_DnaA_C PF08299.11 CDI81142.1 - 0.055 13.5 0.3 0.2 11.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix Nop53 PF07767.11 CDI81142.1 - 0.86 8.9 23.6 0.14 11.5 13.5 2.3 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) RskA PF10099.9 CDI81142.1 - 2.5 8.4 64.6 5.9 7.1 20.4 4.4 1 1 1 2 2 2 0 Anti-sigma-K factor rskA MecA PF05389.12 CDI81142.1 - 4.1 7.0 10.3 1.5 8.4 4.6 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) TFIIA PF03153.13 CDI81142.1 - 5.7 6.8 68.0 16 5.3 31.7 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI81142.1 - 7.6 5.4 15.9 1.5 7.8 10.4 2.0 2 0 0 2 2 2 0 Solute carrier family 12 ELMO_CED12 PF04727.13 CDI81143.1 - 1.7e-21 77.2 9.7 1.8e-20 73.8 9.7 2.4 1 1 0 1 1 1 1 ELMO/CED-12 family RskA PF10099.9 CDI81143.1 - 0.00021 21.6 14.2 0.00021 21.6 14.2 4.8 2 2 3 5 5 5 1 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI81143.1 - 0.14 10.7 24.1 0.035 12.7 20.4 1.9 1 1 0 1 1 1 0 Utp14 protein CBP4 PF07960.11 CDI81143.1 - 2.1 8.2 14.1 9.5 6.1 0.5 2.8 2 0 0 2 2 2 0 CBP4 Caldesmon PF02029.15 CDI81144.1 - 0.081 11.7 26.9 0.13 11.0 26.9 1.2 1 0 0 1 1 1 0 Caldesmon LMBR1 PF04791.16 CDI81144.1 - 0.83 8.5 4.0 0.84 8.5 4.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein eIF-3_zeta PF05091.12 CDI81144.1 - 1.6 7.6 20.0 2.8 6.8 20.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CSG2 PF16965.5 CDI81144.1 - 6.3 5.6 7.6 11 4.9 7.6 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator PP2C PF00481.21 CDI81145.1 - 6.8e-32 111.1 0.0 3.9e-30 105.3 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C RskA PF10099.9 CDI81146.1 - 0.055 13.8 38.2 0.031 14.6 13.6 2.6 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Secretin_N_2 PF07655.13 CDI81146.1 - 0.64 10.6 30.9 0.78 10.3 12.1 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain PAT1 PF09770.9 CDI81146.1 - 4.7 5.4 22.4 5.6 5.1 22.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4770 PF15994.5 CDI81146.1 - 7.5 6.8 13.9 9.2 6.5 13.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4770) SPX PF03105.19 CDI81146.1 - 8.8 6.1 26.5 38 4.0 26.5 1.8 1 1 0 1 1 1 0 SPX domain ABC_tran PF00005.27 CDI81147.1 - 2.1e-27 96.3 0.0 5.7e-18 65.7 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDI81147.1 - 8.4e-10 38.9 2.0 0.011 15.5 0.0 3.2 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDI81147.1 - 3e-08 33.3 0.3 0.0026 17.5 0.1 2.3 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4 PF00037.27 CDI81147.1 - 2.2e-07 30.4 3.7 4.1e-07 29.5 3.7 1.5 1 0 0 1 1 1 1 4Fe-4S binding domain SMC_N PF02463.19 CDI81147.1 - 4.4e-07 29.6 0.4 0.1 12.0 0.0 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDI81147.1 - 1.5e-06 28.2 0.1 0.057 13.1 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CDI81147.1 - 3.9e-06 27.5 0.1 0.0038 17.8 0.1 2.3 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 CDI81147.1 - 5.7e-06 26.4 0.0 0.013 15.4 0.0 2.7 2 1 0 2 2 2 2 Rad17 P-loop domain AAA PF00004.29 CDI81147.1 - 9.1e-06 26.1 0.2 0.037 14.5 0.1 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Fer4_6 PF12837.7 CDI81147.1 - 1.4e-05 24.9 3.0 3.4e-05 23.7 3.0 1.6 1 0 0 1 1 1 1 4Fe-4S binding domain AAA_18 PF13238.6 CDI81147.1 - 1.7e-05 25.4 0.2 0.0049 17.4 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.6 CDI81147.1 - 2.1e-05 24.8 0.1 0.11 12.7 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 CDI81147.1 - 2.2e-05 24.9 0.0 0.19 12.1 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDI81147.1 - 2.3e-05 24.3 0.0 0.031 14.2 0.0 2.7 3 0 0 3 3 2 1 RsgA GTPase AAA_33 PF13671.6 CDI81147.1 - 2.5e-05 24.5 0.1 0.59 10.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CDI81147.1 - 0.00013 21.7 0.1 0.38 10.4 0.0 2.6 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 CDI81147.1 - 0.00015 22.1 0.0 1.4 9.3 0.0 2.9 3 0 0 3 3 3 2 RNA helicase AAA_5 PF07728.14 CDI81147.1 - 0.00016 21.7 0.4 0.56 10.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CDI81147.1 - 0.00017 21.8 0.1 0.32 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 CDI81147.1 - 0.00019 21.1 0.6 0.66 9.6 0.0 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_7 PF12775.7 CDI81147.1 - 0.00026 20.5 0.0 0.08 12.5 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region Fer4_21 PF14697.6 CDI81147.1 - 0.00029 20.9 2.3 0.00073 19.6 2.3 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain NACHT PF05729.12 CDI81147.1 - 0.0004 20.3 0.4 0.16 11.9 0.0 2.4 2 0 0 2 2 2 1 NACHT domain Thymidylate_kin PF02223.17 CDI81147.1 - 0.00047 19.9 0.1 0.33 10.6 0.0 3.1 3 0 0 3 3 3 1 Thymidylate kinase TsaE PF02367.17 CDI81147.1 - 0.00062 19.8 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_2 PF12797.7 CDI81147.1 - 0.00067 19.6 1.1 0.0016 18.4 1.1 1.6 1 0 0 1 1 1 1 4Fe-4S binding domain AAA_27 PF13514.6 CDI81147.1 - 0.001 18.7 0.0 0.51 9.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.6 CDI81147.1 - 0.0012 19.0 0.7 0.0012 19.0 0.7 1.7 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDI81147.1 - 0.0014 19.2 1.5 0.0014 19.2 1.5 1.9 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDI81147.1 - 0.0019 18.3 0.5 0.0034 17.4 0.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_14 PF13173.6 CDI81147.1 - 0.0023 18.0 0.1 4.6 7.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CDI81147.1 - 0.0034 16.6 0.3 2.6 7.1 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 CDI81147.1 - 0.004 16.9 0.3 0.73 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDI81147.1 - 0.0071 15.6 0.3 1.5 8.1 0.0 2.7 3 0 0 3 3 3 1 Zeta toxin MMR_HSR1 PF01926.23 CDI81147.1 - 0.0078 16.3 0.1 1.6 8.8 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase MukB PF04310.12 CDI81147.1 - 0.0083 16.0 0.3 4.7 6.9 0.1 2.4 2 0 0 2 2 2 0 MukB N-terminal MeaB PF03308.16 CDI81147.1 - 0.012 14.6 0.1 0.38 9.7 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 CDI81147.1 - 0.022 14.1 0.2 5.6 6.2 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Mg_chelatase PF01078.21 CDI81147.1 - 0.023 14.1 0.0 0.36 10.2 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI G-alpha PF00503.20 CDI81147.1 - 0.024 13.8 0.0 0.44 9.6 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Fer4_16 PF13484.6 CDI81147.1 - 0.044 14.7 2.8 0.11 13.5 2.8 1.6 1 0 0 1 1 1 0 4Fe-4S double cluster binding domain AAA_13 PF13166.6 CDI81147.1 - 0.047 12.3 2.6 0.65 8.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain VirE PF05272.11 CDI81147.1 - 0.049 13.4 0.1 15 5.3 0.0 2.6 2 1 0 2 2 2 0 Virulence-associated protein E AAA_19 PF13245.6 CDI81147.1 - 0.055 13.8 0.2 18 5.7 0.0 2.6 3 0 0 3 3 2 0 AAA domain Fer4_17 PF13534.6 CDI81147.1 - 0.065 13.8 1.9 0.15 12.6 1.9 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain CLP1_P PF16575.5 CDI81147.1 - 0.091 12.5 0.9 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.6 CDI81147.1 - 0.1 12.1 0.0 17 4.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDI81147.1 - 0.1 11.7 0.1 10 5.2 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain Fer4_8 PF13183.6 CDI81147.1 - 0.11 13.0 0.8 0.21 12.0 0.8 1.4 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDI81147.1 - 0.11 13.0 3.3 0.32 11.6 3.3 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain TrwB_AAD_bind PF10412.9 CDI81147.1 - 0.15 10.9 0.0 3.5 6.4 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Fer4_3 PF12798.7 CDI81147.1 - 0.17 12.9 3.6 0.41 11.7 3.6 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain NTPase_1 PF03266.15 CDI81147.1 - 0.35 10.8 1.2 21 4.9 0.0 2.7 3 0 0 3 3 2 0 NTPase DUF87 PF01935.17 CDI81147.1 - 0.42 10.7 2.8 21 5.1 0.5 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain PA26 PF04636.13 CDI81151.1 - 1.5 7.6 8.7 3.3 6.5 8.7 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SLC12 PF03522.15 CDI81151.1 - 5.3 5.9 10.4 12 4.8 10.4 1.7 1 0 0 1 1 1 0 Solute carrier family 12 Med22 PF06179.12 CDI81152.1 - 3e-05 24.2 0.3 4.3e-05 23.7 0.3 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Trypsin_2 PF13365.6 CDI81156.1 - 9.6e-10 39.5 1.8 6e-06 27.2 0.1 2.5 1 1 1 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 CDI81156.1 - 3.5e-05 23.6 0.1 8.2e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDI81156.1 - 3.7e-05 24.0 0.0 7.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDI81156.1 - 0.00027 21.2 0.0 0.00058 20.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Trypsin PF00089.26 CDI81156.1 - 0.17 11.6 0.0 1.8 8.3 0.0 2.2 2 0 0 2 2 2 0 Trypsin Dpy-30 PF05186.13 CDI81157.1 - 4.1e-06 26.4 0.1 9.2e-06 25.3 0.1 1.6 1 0 0 1 1 1 1 Dpy-30 motif IQ PF00612.27 CDI81159.1 - 0.013 15.2 0.2 0.051 13.4 0.2 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF4460 PF14687.6 CDI81159.1 - 1.5 8.9 5.3 1 9.5 0.5 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4460) PI_PP_I PF18363.1 CDI81159.1 - 5 7.4 6.7 1.2 9.3 1.7 2.5 2 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain Urocanase PF01175.18 CDI81159.1 - 5.4 6.6 8.7 1.2 8.8 1.8 2.5 2 1 0 2 2 2 0 Urocanase Rossmann-like domain DUF724 PF05266.14 CDI81159.1 - 8.2 6.2 33.0 0.085 12.7 12.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF724) Hydantoinase_B PF02538.14 CDI81159.1 - 9 4.6 7.1 14 4.0 7.1 1.4 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase SRP-alpha_N PF04086.13 CDI81163.1 - 6.2 6.6 15.9 0.25 11.2 9.9 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal AP2 PF00847.20 CDI81165.1 - 0.019 15.2 1.6 0.11 12.7 1.5 2.2 2 0 0 2 2 2 0 AP2 domain GST_C_3 PF14497.6 CDI81167.1 - 0.049 13.8 0.1 0.57 10.4 0.1 2.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RPAP3_C PF13877.6 CDI81168.1 - 0.16 12.6 0.7 3 8.4 0.0 2.9 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 NPV_P10 PF05531.12 CDI81168.1 - 0.16 12.4 3.9 1.5 9.4 0.1 3.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 CDI81171.1 - 3.2e-25 89.0 0.0 3.8e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI81171.1 - 2.9e-16 59.5 0.0 3.5e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI81171.1 - 3.4e-08 32.7 0.0 4.4e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase DUF3626 PF12294.8 CDI81172.1 - 1.4e-06 27.6 0.0 2.2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3626) CLN3 PF02487.17 CDI81175.1 - 2.9 6.8 15.8 0.13 11.3 1.1 3.2 3 0 0 3 3 3 0 CLN3 protein Sedlin_N PF04628.13 CDI81177.1 - 0.00027 21.1 0.0 0.0004 20.5 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF5470 PF17564.2 CDI81177.1 - 0.041 14.1 0.9 0.041 14.1 0.9 5.0 2 1 0 2 2 2 0 Family of unknown function (DUF5470) Presenilin PF01080.17 CDI81177.1 - 0.58 8.9 10.2 0.78 8.4 10.2 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 CDI81177.1 - 2.5 6.4 7.6 3.2 6.0 7.6 1.3 1 0 0 1 1 1 0 Menin SPX PF03105.19 CDI81177.1 - 4.8 7.0 29.7 8.7 6.1 29.7 1.4 1 1 0 1 1 1 0 SPX domain Hid1 PF12722.7 CDI81177.1 - 7.4 4.6 12.9 9.1 4.3 12.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DnaJ PF00226.31 CDI81179.1 - 0.014 15.5 0.1 0.061 13.5 0.0 2.1 2 0 0 2 2 2 0 DnaJ domain Med15 PF09606.10 CDI81179.1 - 1.7 7.3 58.5 0.038 12.7 9.3 2.5 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 CDI81179.1 - 3.7 7.4 73.5 2.9 7.8 12.6 2.6 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RXLR PF16810.5 CDI81179.1 - 4.1 7.8 13.5 0.51 10.8 4.3 2.7 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity FAM60A PF15396.6 CDI81179.1 - 9.8 6.1 21.3 9.4 6.2 8.9 3.3 3 0 0 3 3 3 0 Protein Family FAM60A CLP1_P PF16575.5 CDI81183.1 - 6.2e-09 35.9 0.2 1.5e-05 24.9 0.0 3.1 2 1 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop Spt20 PF12090.8 CDI81183.1 - 0.0058 16.3 12.3 0.0058 16.3 12.3 8.3 7 2 0 7 7 7 1 Spt20 family RskA PF10099.9 CDI81183.1 - 0.0087 16.4 19.2 0.0087 16.4 19.2 8.7 3 2 1 6 6 6 2 Anti-sigma-K factor rskA Methyltransf_23 PF13489.6 CDI81183.1 - 0.11 12.3 0.1 0.11 12.3 0.1 3.0 3 0 0 3 3 3 0 Methyltransferase domain KCNQC3-Ank-G_bd PF11956.8 CDI81186.1 - 0.02 15.2 0.7 0.098 12.9 0.1 2.3 2 0 0 2 2 2 0 Ankyrin-G binding motif of KCNQ2-3 SOG2 PF10428.9 CDI81187.1 - 0.057 12.6 13.0 0.056 12.6 13.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF966 PF06136.13 CDI81187.1 - 0.42 10.3 9.1 0.57 9.8 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BBS2_C PF14782.6 CDI81188.1 - 0.0067 15.2 1.9 0.0081 15.0 1.9 1.2 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal TFIIA PF03153.13 CDI81188.1 - 0.011 15.8 9.4 0.013 15.5 9.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Activator_LAG-3 PF11498.8 CDI81188.1 - 0.012 14.7 13.9 0.013 14.5 13.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Pep_M12B_propep PF01562.19 CDI81188.1 - 0.018 15.3 0.1 0.031 14.5 0.1 1.4 1 0 0 1 1 1 0 Reprolysin family propeptide THOC2_N PF16134.5 CDI81188.1 - 0.021 13.5 1.6 0.026 13.2 1.6 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Spt20 PF12090.8 CDI81188.1 - 0.066 12.8 7.8 0.08 12.5 7.8 1.2 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI81188.1 - 0.17 11.0 13.5 0.31 10.2 13.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SurA_N PF09312.11 CDI81188.1 - 0.33 11.0 7.6 0.54 10.3 7.6 1.3 1 0 0 1 1 1 0 SurA N-terminal domain DUF3381 PF11861.8 CDI81188.1 - 0.36 10.6 5.1 0.5 10.1 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) RskA PF10099.9 CDI81188.1 - 7.5 6.8 23.0 1.8 8.8 18.7 1.8 1 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF4589 PF15252.6 CDI81189.1 - 0.045 13.8 5.4 0.052 13.6 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) Pex14_N PF04695.13 CDI81189.1 - 0.86 10.2 21.2 0.9 10.2 21.2 1.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_U57 PF05582.12 CDI81189.1 - 1.6 7.9 11.4 1.6 7.9 11.4 1.0 1 0 0 1 1 1 0 YabG peptidase U57 SpoIIP PF07454.11 CDI81189.1 - 2.3 7.6 15.1 2.6 7.4 15.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Cellulose_synt PF03552.14 CDI81189.1 - 2.9 6.3 8.2 2.8 6.3 8.2 1.0 1 0 0 1 1 1 0 Cellulose synthase Baculo_PP31 PF05311.11 CDI81189.1 - 3 7.2 16.2 3.3 7.1 16.2 1.0 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Ureide_permease PF07168.11 CDI81189.1 - 3.9 6.1 6.9 4 6.1 6.9 1.0 1 0 0 1 1 1 0 Ureide permease CTU2 PF10288.9 CDI81189.1 - 5.4 7.3 16.9 6.4 7.1 16.9 1.1 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Presenilin PF01080.17 CDI81189.1 - 6 5.5 16.4 6.5 5.4 16.4 1.0 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI81189.1 - 6.1 6.5 11.2 6 6.6 11.2 1.1 1 0 0 1 1 1 0 Connexin PAT1 PF09770.9 CDI81189.1 - 8.2 4.5 26.1 8.5 4.5 26.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AIF_C PF14721.6 CDI81189.1 - 9 6.7 10.7 12 6.3 10.7 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term eIF-3_zeta PF05091.12 CDI81189.1 - 9.5 5.1 20.7 9.4 5.1 20.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Serinc PF03348.15 CDI81189.1 - 9.5 5.0 9.9 9.1 5.1 9.9 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) AP2 PF00847.20 CDI81190.1 - 1.4e-20 73.3 4.0 1.8e-12 47.3 0.7 3.8 5 0 0 5 5 5 2 AP2 domain DUF1700 PF08006.11 CDI81192.1 - 0.052 13.1 2.6 0.29 10.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Lin-8 PF03353.15 CDI81193.1 - 0.0004 20.1 13.6 0.0004 20.1 13.6 6.6 3 1 2 6 6 6 1 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI81193.1 - 0.0022 18.0 4.8 0.0022 18.0 4.8 5.3 3 1 1 4 4 4 2 SPX domain TATR PF03430.13 CDI81193.1 - 0.24 9.7 5.0 0.46 8.8 5.0 1.4 1 0 0 1 1 1 0 Trans-activating transcriptional regulator AP2 PF00847.20 CDI81195.1 - 1.6e-09 37.8 2.4 1.6e-09 37.8 2.4 2.7 2 0 0 2 2 2 1 AP2 domain Lin-8 PF03353.15 CDI81195.1 - 1.8 8.0 29.6 1.3 8.6 7.4 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF4129 PF13559.6 CDI81197.1 - 0.034 14.4 0.1 0.061 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Gti1_Pac2 PF09729.9 CDI81198.1 - 4.6 7.3 6.7 28 4.7 5.8 2.5 2 0 0 2 2 2 0 Gti1/Pac2 family DUF3801 PF12687.7 CDI81198.1 - 8.3 6.4 13.3 0.46 10.5 3.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3801) Abhydro_lipase PF04083.16 CDI81200.1 - 2.2e-05 23.9 0.0 0.00016 21.2 0.0 2.3 1 1 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CDI81200.1 - 0.0061 16.2 3.4 0.067 12.8 0.0 3.7 4 0 0 4 4 4 1 alpha/beta hydrolase fold TFIIA PF03153.13 CDI81200.1 - 8 6.3 67.9 2.6 7.9 19.1 4.1 4 0 0 4 4 4 0 Transcription factor IIA, alpha/beta subunit Haem_bd PF14376.6 CDI81201.1 - 0.00056 19.9 0.0 1.4 8.9 0.0 3.2 3 0 0 3 3 3 2 Haem-binding domain Apolipo_F PF15148.6 CDI81201.1 - 0.02 14.4 0.2 6.9 6.1 0.0 2.6 2 0 0 2 2 2 0 Apolipoprotein F NOP19 PF10863.8 CDI81201.1 - 0.027 14.3 0.5 24 4.7 0.0 3.1 3 0 0 3 3 3 0 Nucleolar protein 19 Tir_receptor_M PF03549.14 CDI81201.1 - 0.18 12.1 0.0 37 4.7 0.0 2.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) intimin-binding domain Orthopox_C10L PF07020.11 CDI81203.1 - 0.14 12.9 0.8 0.24 12.2 0.1 1.7 2 0 0 2 2 2 0 Orthopoxvirus C10L protein CDC45 PF02724.14 CDI81203.1 - 0.25 9.6 9.4 0.29 9.4 9.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Phage_Gp23 PF10669.9 CDI81203.1 - 1.8 8.9 5.1 8.1 6.8 5.7 1.7 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Peptidase_M14 PF00246.24 CDI81204.1 - 8e-08 32.4 0.0 0.0063 16.3 0.0 2.8 2 0 0 2 2 2 2 Zinc carboxypeptidase Nrf1_DNA-bind PF10491.9 CDI81204.1 - 0.14 11.9 2.3 13 5.4 0.1 2.7 2 0 0 2 2 2 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 F-box-like_2 PF13013.6 CDI81204.1 - 0.15 12.0 0.3 11 6.0 0.0 2.9 3 0 0 3 3 3 0 F-box-like domain GTP_cyclohydro2 PF00925.20 CDI81204.1 - 1.8 8.1 4.2 26 4.3 0.4 2.6 2 0 0 2 2 2 0 GTP cyclohydrolase II DotU PF09850.9 CDI81204.1 - 6.8 6.3 15.6 2.6 7.7 0.8 3.5 3 0 0 3 3 3 0 Type VI secretion system protein DotU Calc_CGRP_IAPP PF00214.19 CDI81204.1 - 7.3 7.0 11.5 0.75 10.2 0.1 3.9 3 0 0 3 3 3 0 Calcitonin / CGRP / IAPP family EF-hand_7 PF13499.6 CDI81205.1 - 2.7e-13 50.2 3.5 5.9e-13 49.1 3.5 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CDI81205.1 - 9.1e-12 44.6 0.9 2.2e-11 43.4 0.9 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CDI81205.1 - 3.7e-11 42.0 1.3 1.6e-05 24.4 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDI81205.1 - 2.6e-10 39.1 3.1 4.4e-06 25.9 0.8 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 CDI81205.1 - 1.9e-09 36.6 3.8 2.2e-06 26.9 1.0 2.6 2 0 0 2 2 2 2 EF hand COPI_assoc PF08507.10 CDI81205.1 - 1.1e-08 35.2 2.4 1.4e-08 34.8 2.4 1.1 1 0 0 1 1 1 1 COPI associated protein SPARC_Ca_bdg PF10591.9 CDI81205.1 - 7.1e-07 29.5 2.7 1.4e-06 28.6 2.7 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1840 PF08895.11 CDI81205.1 - 1.2 9.5 6.1 5 7.5 2.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) Presenilin PF01080.17 CDI81208.1 - 2.3e-05 23.4 4.9 0.00053 18.9 0.9 2.3 2 0 0 2 2 2 2 Presenilin SUIM_assoc PF16619.5 CDI81208.1 - 0.002 18.1 0.1 0.002 18.1 0.1 6.0 4 1 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI81208.1 - 0.0087 16.1 38.4 0.0087 16.1 38.4 3.7 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit LMBR1 PF04791.16 CDI81208.1 - 0.23 10.3 0.1 0.38 9.6 0.1 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_28 PF13521.6 CDI81208.1 - 1.4 9.2 0.0 1.4 9.2 0.0 3.4 4 0 0 4 4 4 0 AAA domain SPX PF03105.19 CDI81210.1 - 0.0052 16.7 19.0 0.036 14.0 17.0 2.4 1 1 0 1 1 1 1 SPX domain Nup54 PF13874.6 CDI81214.1 - 0.00036 20.6 0.4 0.00036 20.6 0.4 4.0 2 1 1 3 3 3 1 Nucleoporin complex subunit 54 HTH_30 PF13556.6 CDI81214.1 - 0.032 14.0 0.0 0.16 11.8 0.0 2.2 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain IMUP PF15761.5 CDI81214.1 - 0.35 11.6 6.2 1 10.1 1.0 3.0 3 0 0 3 3 3 0 Immortalisation up-regulated protein HisKA PF00512.25 CDI81214.1 - 5.2 7.2 7.7 9.2 6.4 1.2 3.8 4 1 0 4 4 4 0 His Kinase A (phospho-acceptor) domain ApoO PF09769.9 CDI81215.1 - 0.038 13.9 4.4 0.41 10.6 0.3 3.7 2 2 2 4 4 4 0 Apolipoprotein O CxC1 PF18802.1 CDI81215.1 - 0.13 12.5 0.0 1.8 8.8 0.0 2.5 2 0 0 2 2 2 0 CxC1 like cysteine cluster associated with KDZ transposases Thiolase_N PF00108.23 CDI81216.1 - 7.5e-51 173.0 0.0 3.9e-27 95.3 0.0 3.1 3 0 0 3 3 3 3 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDI81216.1 - 7.1e-23 80.6 2.4 8.2e-23 80.4 0.1 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDI81216.1 - 4.9e-08 32.9 7.7 4.7e-06 26.4 4.4 3.2 2 1 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CDI81216.1 - 1.4e-05 24.9 3.1 0.049 13.5 0.1 3.2 3 0 0 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Fer4_15 PF13459.6 CDI81216.1 - 0.073 13.8 0.1 0.73 10.6 0.0 2.4 2 0 0 2 2 2 0 4Fe-4S single cluster domain RAP PF08373.10 CDI81221.1 - 2.6e-05 24.2 0.0 4.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 RAP domain TFIIA PF03153.13 CDI81221.1 - 1.6 8.7 36.1 1.4 8.9 11.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit GATA PF00320.27 CDI81223.1 - 3.4e-07 29.8 3.6 6.7e-07 28.8 3.6 1.5 1 0 0 1 1 1 1 GATA zinc finger AMP-binding PF00501.28 CDI81224.1 - 2.5e-83 280.0 0.0 3.2e-83 279.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDI81224.1 - 2.6e-22 79.6 1.3 5.4e-22 78.6 1.3 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1846 PF08903.11 CDI81225.1 - 0.53 8.8 2.3 1.1 7.7 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) SPX PF03105.19 CDI81226.1 - 0.00059 19.9 1.5 0.001 19.1 1.5 1.5 1 0 0 1 1 1 1 SPX domain MAP65_ASE1 PF03999.12 CDI81226.1 - 1.3 7.7 10.3 2.3 6.8 10.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Apt1 PF10351.9 CDI81226.1 - 3.6 6.3 10.0 5.7 5.7 10.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain NUDE_C PF04880.13 CDI81226.1 - 9.5 6.7 17.2 0.78 10.2 11.8 1.9 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region SUIM_assoc PF16619.5 CDI81227.1 - 0.0063 16.6 2.1 0.0063 16.6 2.1 9.9 9 1 0 9 9 9 2 Unstructured region C-term to UIM in Ataxin3 UMPH-1 PF05822.12 CDI81227.1 - 0.053 13.0 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) PhoLip_ATPase_C PF16212.5 CDI81228.1 - 3.3 7.4 12.4 0.32 10.7 6.0 2.1 2 0 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal Ribosomal_L7Ae PF01248.26 CDI81229.1 - 1.2e-27 95.4 0.6 1.5e-27 95.1 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.12 CDI81229.1 - 0.0066 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding CAP PF00188.26 CDI81232.1 - 0.00063 20.6 0.0 0.0011 19.7 0.0 1.6 1 1 0 1 1 1 1 Cysteine-rich secretory protein family p450 PF00067.22 CDI81232.1 - 0.091 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 EnY2 PF10163.9 CDI81233.1 - 4.9e-06 26.8 0.0 4.9e-06 26.8 0.0 1.6 2 0 0 2 2 2 1 Transcription factor e(y)2 ABC2_membrane_3 PF12698.7 CDI81237.1 - 0.21 10.7 0.1 0.21 10.7 0.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Y2_Tnp PF04986.13 CDI81237.1 - 0.21 11.6 3.8 0.22 11.5 2.7 1.5 2 0 0 2 2 2 0 Putative transposase Exonuc_VII_L PF02601.15 CDI81237.1 - 0.31 10.6 9.6 0.75 9.3 8.8 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4407 PF14362.6 CDI81237.1 - 0.46 9.8 7.7 0.77 9.0 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMEM43 PF07787.12 CDI81237.1 - 0.48 9.8 7.8 1.2 8.5 6.0 2.0 2 0 0 2 2 2 0 Transmembrane protein 43 FKBP_N PF01346.18 CDI81237.1 - 1 10.4 13.5 1.2 10.2 11.6 1.9 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF2924 PF11149.8 CDI81237.1 - 2.3 8.6 8.5 3.4 8.1 6.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) Spt20 PF12090.8 CDI81237.1 - 2.8 7.5 21.9 4.3 6.9 21.9 1.3 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI81237.1 - 3.1 8.1 11.2 6.1 7.1 11.2 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA OmpH PF03938.14 CDI81237.1 - 4.4 7.6 30.1 21 5.5 28.8 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) 2-Hacid_dh_C PF02826.19 CDI81240.1 - 0.081 12.3 2.8 2.1 7.7 0.1 2.5 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Hid1 PF12722.7 CDI81240.1 - 8.3 4.4 11.5 12 3.9 11.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein fn2 PF00040.19 CDI81241.1 - 0.00021 21.5 1.5 0.00043 20.5 1.5 1.6 1 0 0 1 1 1 1 Fibronectin type II domain RR_TM4-6 PF06459.12 CDI81242.1 - 0.65 9.8 28.8 0.74 9.6 28.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VIR_N PF15912.5 CDI81242.1 - 1.8 8.1 15.2 1.8 8.1 15.2 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal Rtf2 PF04641.12 CDI81242.1 - 2.7 7.3 21.7 2.7 7.3 21.7 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger TCP PF03634.13 CDI81242.1 - 2.7 8.6 24.5 3.3 8.3 24.5 1.1 1 0 0 1 1 1 0 TCP family transcription factor NARP1 PF12569.8 CDI81242.1 - 2.8 6.7 21.5 3.2 6.6 21.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SPX PF03105.19 CDI81243.1 - 1.3 8.8 16.8 1.5 8.7 16.8 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI81243.1 - 9.8 4.9 18.3 10 4.8 18.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain GTP_EFTU PF00009.27 CDI81244.1 - 6.1e-31 107.5 6.8 8e-29 100.6 6.8 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Macoilin PF09726.9 CDI81244.1 - 9e-05 21.2 29.7 0.00014 20.6 29.7 1.3 1 0 0 1 1 1 1 Macoilin family MMR_HSR1 PF01926.23 CDI81244.1 - 0.00088 19.3 1.1 0.0018 18.3 0.0 2.0 2 1 0 2 2 1 1 50S ribosome-binding GTPase Coilin_N PF15862.5 CDI81244.1 - 0.0043 16.9 12.2 0.0043 16.9 12.2 2.6 2 1 0 2 2 1 1 Coilin N-terminus RR_TM4-6 PF06459.12 CDI81244.1 - 0.0075 16.1 14.8 0.0075 16.1 14.8 2.0 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 DUF4698 PF15769.5 CDI81244.1 - 0.031 13.3 20.0 0.073 12.1 19.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4698) CobT PF06213.12 CDI81244.1 - 0.2 11.0 40.6 0.022 14.1 25.8 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 CDI81244.1 - 0.21 11.8 18.0 0.7 10.1 12.7 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal NARP1 PF12569.8 CDI81244.1 - 0.31 9.9 16.3 0.4 9.5 16.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF3807 PF12720.7 CDI81244.1 - 0.34 11.2 29.9 0.67 10.2 22.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) eIF-3_zeta PF05091.12 CDI81244.1 - 0.57 9.1 20.2 0.9 8.4 20.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EPL1 PF10513.9 CDI81244.1 - 0.77 10.1 31.0 0.69 10.3 0.5 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like Presenilin PF01080.17 CDI81244.1 - 1.1 8.0 34.9 0.83 8.3 20.2 2.1 2 0 0 2 2 2 0 Presenilin SLC12 PF03522.15 CDI81244.1 - 1.2 8.1 22.7 0.63 9.0 15.4 2.0 2 0 0 2 2 2 0 Solute carrier family 12 CCDC53 PF10152.9 CDI81244.1 - 1.4 9.3 22.8 0.35 11.3 15.6 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex PAT1 PF09770.9 CDI81244.1 - 1.8 6.7 26.3 2.4 6.3 26.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF5523 PF17661.1 CDI81244.1 - 2.2 7.9 22.0 0.057 13.1 15.6 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RNA_pol_Rpc4 PF05132.14 CDI81244.1 - 2.3 8.6 23.5 1 9.8 13.2 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 PNISR PF15996.5 CDI81244.1 - 2.3 8.4 31.8 2.8 8.2 20.3 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF913 PF06025.12 CDI81244.1 - 2.6 6.9 23.7 1 8.2 10.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) GEMIN8 PF15348.6 CDI81244.1 - 3.1 8.0 30.3 0.64 10.3 14.4 2.1 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 LMBR1 PF04791.16 CDI81244.1 - 3.2 6.6 5.4 2.7 6.8 5.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PIP5K PF01504.18 CDI81244.1 - 3.6 6.7 23.1 2.9 7.0 0.3 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase SAPS PF04499.15 CDI81244.1 - 3.7 6.2 19.5 0.19 10.5 8.8 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Asparaginase_2 PF01112.18 CDI81244.1 - 3.7 6.5 11.6 5.4 6.0 11.6 1.2 1 0 0 1 1 1 0 Asparaginase DUF4820 PF16091.5 CDI81244.1 - 4.7 6.5 25.2 0.46 9.8 10.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) FAM176 PF14851.6 CDI81244.1 - 8.4 6.0 20.8 9.2 5.9 0.5 2.3 2 0 0 2 2 2 0 FAM176 family SDA1 PF05285.12 CDI81244.1 - 8.5 5.7 27.4 5.7 6.3 16.0 2.0 2 0 0 2 2 2 0 SDA1 TFIIA PF03153.13 CDI81248.1 - 0.12 12.4 49.0 0.17 11.9 49.0 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MMR1 PF08505.10 CDI81248.1 - 1.4 9.1 20.4 2 8.7 20.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Shadoo PF14999.6 CDI81248.1 - 2.1 8.4 14.5 0.54 10.4 6.4 2.1 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective PAT1 PF09770.9 CDI81248.1 - 3.3 5.8 35.6 3.6 5.8 35.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EIF4E-T PF10477.9 CDI81248.1 - 3.6 6.3 25.2 4.6 5.9 25.2 1.3 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CLPTM1 PF05602.12 CDI81248.1 - 3.7 6.5 10.2 4.7 6.1 10.2 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Ribosomal_60s PF00428.19 CDI81248.1 - 4 8.1 23.4 4.2 8.0 3.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Exonuc_VII_L PF02601.15 CDI81248.1 - 5.8 6.4 24.7 7.5 6.0 24.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Presenilin PF01080.17 CDI81248.1 - 8.1 5.1 14.3 10 4.7 14.3 1.3 1 0 0 1 1 1 0 Presenilin Med15 PF09606.10 CDI81252.1 - 0.0004 19.2 7.6 0.0004 19.2 7.6 2.3 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI81252.1 - 0.0061 15.6 14.6 0.0061 15.6 14.6 3.4 3 1 0 4 4 4 1 Protein of unknown function (DUF2722) DUF2126 PF09899.9 CDI81252.1 - 1 7.3 11.6 0.071 11.2 2.0 2.3 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) CDK5_activator PF03261.15 CDI81252.1 - 7.2 6.1 9.3 4 6.9 1.7 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein eIF-3_zeta PF05091.12 CDI81252.1 - 8.4 5.2 17.4 2.2 7.2 4.3 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 CDI81252.1 - 8.4 6.3 65.5 0.048 13.7 25.1 2.7 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Sugar_tr PF00083.24 CDI81255.1 - 1.1e-40 139.9 22.8 2.8e-33 115.5 3.1 3.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDI81255.1 - 1.6e-13 50.3 50.5 4.3e-12 45.6 50.5 3.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Pex26 PF07163.12 CDI81255.1 - 0.0038 16.6 3.2 0.0038 16.6 3.2 2.7 3 0 0 3 3 2 1 Pex26 protein V_ATPase_I PF01496.19 CDI81255.1 - 0.0088 14.0 0.4 0.086 10.7 0.4 2.0 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family Sporozoite_P67 PF05642.11 CDI81255.1 - 0.018 13.1 0.2 0.042 12.0 0.2 1.5 1 1 0 1 1 1 0 Sporozoite P67 surface antigen CbiD PF01888.17 CDI81255.1 - 0.036 13.4 0.1 0.036 13.4 0.1 3.0 3 1 0 3 3 2 0 CbiD PRTase_1 PF11202.8 CDI81255.1 - 0.094 11.9 2.3 0.18 11.0 2.3 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) Spt20 PF12090.8 CDI81255.1 - 0.16 11.6 32.0 0.017 14.7 8.9 2.1 2 0 0 2 2 2 0 Spt20 family DDHD PF02862.17 CDI81255.1 - 1.3 9.2 5.6 0.89 9.7 0.3 2.1 2 0 0 2 2 2 0 DDHD domain PPL5 PF18168.1 CDI81255.1 - 1.3 8.3 4.9 0.29 10.4 0.1 2.1 2 0 0 2 2 2 0 Prim-pol family 5 Acatn PF13000.7 CDI81255.1 - 1.4 7.3 7.0 0.058 11.9 0.7 1.7 2 0 0 2 2 2 0 Acetyl-coenzyme A transporter 1 TFIIA PF03153.13 CDI81255.1 - 1.5 8.7 36.8 3.7 7.4 13.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MPM1 PF17234.2 CDI81255.1 - 1.9 8.7 16.1 0.4 10.9 2.2 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 TPPK_C PF12555.8 CDI81255.1 - 3.1 7.9 7.8 0.24 11.4 0.7 3.1 2 0 0 2 2 1 0 Thiamine pyrophosphokinase C terminal FliD_N PF02465.18 CDI81255.1 - 6.1 7.6 28.3 4 8.2 12.2 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus HemX PF04375.14 CDI81255.1 - 6.3 6.0 30.4 1.9 7.7 9.2 2.2 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Dus PF01207.17 CDI81256.1 - 3e-13 49.6 22.4 4.9e-08 32.4 11.4 4.6 3 1 0 3 3 3 2 Dihydrouridine synthase (Dus) Rad52_Rad22 PF04098.15 CDI81256.1 - 0.14 12.1 7.4 0.44 10.4 2.5 2.4 2 0 0 2 2 2 0 Rad52/22 family double-strand break repair protein SPX PF03105.19 CDI81256.1 - 2.9 7.7 39.2 0.25 11.2 11.8 2.6 2 1 0 2 2 2 0 SPX domain Nop14 PF04147.12 CDI81257.1 - 5.2e-09 34.9 77.7 5.2e-09 34.9 77.7 6.3 5 1 1 6 6 6 4 Nop14-like family RNA_pol_A_bac PF01000.26 CDI81258.1 - 3.3e-08 33.9 0.0 1.4e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain Peptidase_S49_N PF08496.10 CDI81258.1 - 0.64 10.1 0.0 0.64 10.1 0.0 4.6 4 1 0 4 4 4 0 Peptidase family S49 N-terminal HhH-GPD PF00730.25 CDI81259.1 - 2.7e-20 72.8 0.8 5.2e-20 71.9 0.0 1.9 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDI81259.1 - 2e-06 27.3 0.0 4.2e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif TFIIA PF03153.13 CDI81259.1 - 7.3 6.5 41.2 12 5.8 41.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3223 PF11523.8 CDI81260.1 - 1.5e-08 35.4 3.0 1.8e-07 31.9 0.0 4.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3223) PBP PF01161.20 CDI81260.1 - 6.7e-08 32.9 0.0 6.2e-07 29.8 0.0 2.8 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Activator_LAG-3 PF11498.8 CDI81261.1 - 0.0034 16.4 41.9 0.0076 15.3 15.4 2.2 2 0 0 2 2 2 2 Transcriptional activator LAG-3 RskA PF10099.9 CDI81261.1 - 0.17 12.2 35.3 0.082 13.2 13.4 2.3 1 1 1 2 2 2 0 Anti-sigma-K factor rskA RIFIN PF02009.16 CDI81261.1 - 0.69 9.8 9.6 0.19 11.6 5.9 1.7 2 0 0 2 2 2 0 Rifin Ndc1_Nup PF09531.10 CDI81261.1 - 4 6.0 12.5 4.9 5.7 12.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spt20 PF12090.8 CDI81261.1 - 4 7.0 25.4 5.1 6.6 11.5 2.2 2 0 0 2 2 2 0 Spt20 family Peptidase_S15 PF02129.18 CDI81261.1 - 6.9 6.2 19.9 0.2 11.2 4.3 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF702 PF05142.12 CDI81261.1 - 7.1 7.1 13.1 9.8 6.6 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Choline_kinase PF01633.20 CDI81262.1 - 1.9e-39 135.5 0.0 1.3e-38 132.8 0.0 2.2 3 0 0 3 3 3 1 Choline/ethanolamine kinase APH PF01636.23 CDI81262.1 - 8.1e-15 55.4 2.1 8.1e-15 55.4 2.1 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDI81262.1 - 0.00023 20.6 0.1 0.00023 20.6 0.1 2.5 2 1 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 CDI81262.1 - 0.0023 16.9 0.4 0.016 14.1 0.0 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1679) Hep_59 PF07052.11 CDI81262.1 - 3.8 8.3 11.0 2.3 9.0 0.3 3.2 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 DUF5320 PF17253.2 CDI81262.1 - 4.4 8.4 9.5 11 7.2 3.8 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5320) RskA PF10099.9 CDI81262.1 - 7.6 6.8 15.9 8.3 6.7 9.7 2.5 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Helicase_C PF00271.31 CDI81263.1 - 0.00054 20.3 0.0 0.0013 19.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribosomal_60s PF00428.19 CDI81263.1 - 9 7.0 18.6 0.83 10.3 0.5 3.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein Iso_dh PF00180.20 CDI81264.1 - 6.2e-69 232.8 0.0 7.4e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase V_ATPase_I PF01496.19 CDI81265.1 - 0.61 7.9 14.8 0.72 7.7 14.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SDH_alpha PF03313.15 CDI81265.1 - 1.3 8.7 3.1 1.7 8.3 3.1 1.2 1 0 0 1 1 1 0 Serine dehydratase alpha chain DUF1168 PF06658.12 CDI81265.1 - 1.8 8.4 21.2 2.7 7.8 21.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Ureide_permease PF07168.11 CDI81265.1 - 4.3 6.0 4.7 6.2 5.5 4.7 1.4 1 0 0 1 1 1 0 Ureide permease Neur_chan_memb PF02932.16 CDI81265.1 - 5 7.1 15.5 7.9 6.5 15.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EIIBC-GUT_N PF03612.14 CDI81265.1 - 6.7 6.4 0.0 6.7 6.4 0.0 3.3 1 1 1 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus AF-4 PF05110.13 CDI81265.1 - 9.6 4.1 28.3 12 3.9 28.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIA PF03153.13 CDI81267.1 - 3.6e-09 37.1 0.0 4e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Herpes_pp85 PF04637.12 CDI81268.1 - 0.76 8.1 7.3 1.4 7.3 7.3 1.5 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Spt20 PF12090.8 CDI81268.1 - 4.8 6.7 40.8 0.35 10.5 13.7 3.4 3 0 0 3 3 3 0 Spt20 family Med3 PF11593.8 CDI81270.1 - 0.01 15.1 8.5 0.012 14.8 8.5 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal AP2 PF00847.20 CDI81271.1 - 7e-12 45.4 0.1 1.9e-11 44.0 0.1 1.8 1 0 0 1 1 1 1 AP2 domain KIAA1430 PF13879.6 CDI81271.1 - 1.3 9.8 8.0 3.1 8.6 8.0 1.5 1 0 0 1 1 1 0 KIAA1430 homologue AP2 PF00847.20 CDI81272.1 - 9.4e-10 38.6 0.0 1.7e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 AP2 domain RNA_pol_Rpc4 PF05132.14 CDI81273.1 - 3.5e-15 56.7 0.1 3.5e-15 56.7 0.1 3.4 3 1 0 3 3 3 1 RNA polymerase III RPC4 Corona_I PF03187.14 CDI81273.1 - 0.022 14.4 0.1 0.04 13.6 0.1 1.3 1 0 0 1 1 1 0 Corona nucleocapsid I protein DUF5137 PF17220.3 CDI81273.1 - 8.6 7.3 9.1 3.1 8.7 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF5137) Rtt106 PF08512.12 CDI81275.1 - 1.1e-24 86.7 1.0 1.1e-23 83.5 0.1 2.7 3 0 0 3 3 3 1 Histone chaperone Rttp106-like POB3_N PF17292.2 CDI81275.1 - 2e-24 85.8 0.1 1.2e-23 83.4 0.1 2.3 2 0 0 2 2 2 1 POB3-like N-terminal PH domain SSrecog PF03531.14 CDI81275.1 - 4.8e-16 58.4 0.2 5.3e-15 55.1 0.0 2.7 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) YL1 PF05764.13 CDI81275.1 - 0.00022 21.4 19.1 0.00044 20.4 19.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein CCDC106 PF15794.5 CDI81275.1 - 0.9 9.2 11.6 1.7 8.3 11.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 NOA36 PF06524.12 CDI81275.1 - 1.2 8.4 12.0 1.9 7.7 12.0 1.2 1 0 0 1 1 1 0 NOA36 protein YajC PF02699.15 CDI81278.1 - 0.0029 17.4 1.6 0.0029 17.4 1.6 4.0 4 0 0 4 4 4 1 Preprotein translocase subunit TMEM164 PF14808.6 CDI81278.1 - 0.21 10.9 0.0 0.39 10.0 0.0 1.3 1 0 0 1 1 1 0 TMEM164 family Vps35 PF03635.17 CDI81279.1 - 1.9e-196 654.8 1.2 6.5e-147 491.1 0.1 2.2 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 35 RNA_pol_Rpb2_1 PF04563.15 CDI81280.1 - 1e-36 126.4 0.0 1.2e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CDI81280.1 - 6.6e-20 71.5 0.0 1.3e-19 70.6 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF4201 PF13870.6 CDI81281.1 - 4.8e-09 36.2 13.5 4.8e-09 36.2 13.5 4.3 4 1 1 5 5 5 1 Domain of unknown function (DUF4201) UPF0524 PF15823.5 CDI81281.1 - 2.4 7.5 6.2 0.51 9.7 0.9 2.2 2 0 0 2 2 2 0 UPF0524 of C3orf70 CCSAP PF15748.5 CDI81283.1 - 0.051 13.7 30.1 0.06 13.5 30.1 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TCP PF03634.13 CDI81283.1 - 0.1 13.1 25.4 0.13 12.8 25.4 1.1 1 0 0 1 1 1 0 TCP family transcription factor SR-25 PF10500.9 CDI81283.1 - 0.17 11.5 33.3 0.53 9.9 33.3 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1682 PF07946.14 CDI81283.1 - 0.41 9.8 15.5 0.46 9.6 15.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RR_TM4-6 PF06459.12 CDI81283.1 - 0.63 9.8 23.1 0.74 9.6 23.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 CDI81283.1 - 0.88 8.3 17.8 1 8.1 17.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 eIF-3_zeta PF05091.12 CDI81283.1 - 0.93 8.4 24.9 1 8.2 24.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF572 PF04502.13 CDI81283.1 - 1.2 8.7 24.7 1.3 8.6 24.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) AAA_23 PF13476.6 CDI81283.1 - 2.5 8.6 21.4 3 8.3 21.4 1.2 1 0 0 1 1 1 0 AAA domain NARP1 PF12569.8 CDI81283.1 - 3.4 6.5 21.0 3.6 6.4 21.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AAA_11 PF13086.6 CDI81283.1 - 3.4 7.4 22.3 4.1 7.1 22.3 1.1 1 0 0 1 1 1 0 AAA domain PAT1 PF09770.9 CDI81283.1 - 3.7 5.7 32.2 3.8 5.6 32.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 N6_N4_Mtase PF01555.18 CDI81283.1 - 4 7.1 11.7 4.5 6.9 11.7 1.1 1 0 0 1 1 1 0 DNA methylase CDC45 PF02724.14 CDI81283.1 - 4.1 5.6 20.5 4.5 5.4 20.5 1.1 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 CDI81283.1 - 5.6 6.5 21.6 6.8 6.2 21.6 1.1 1 0 0 1 1 1 0 PPP4R2 V_ATPase_I PF01496.19 CDI81283.1 - 6.5 4.5 22.8 6.8 4.5 22.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MRP-S27 PF10037.9 CDI81283.1 - 7.8 5.2 22.5 8.9 5.1 22.5 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 VIR_N PF15912.5 CDI81283.1 - 7.9 6.0 14.3 8.7 5.9 14.3 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4746 PF15928.5 CDI81283.1 - 7.9 5.8 19.6 9.2 5.6 19.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.15 CDI81283.1 - 9 5.2 24.3 10 5.0 24.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TFIIA PF03153.13 CDI81284.1 - 0.0072 16.4 61.0 0.01 15.9 61.0 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI81284.1 - 2.5 6.3 48.0 2.7 6.1 48.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 KH_1 PF00013.29 CDI81287.1 - 2.9e-16 59.0 0.0 3.6e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 CDI81287.1 - 0.00041 20.2 1.6 0.35 10.8 0.3 2.7 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 CDI81287.1 - 0.00058 19.6 0.2 0.079 12.8 0.0 2.4 2 0 0 2 2 2 1 KH domain Activator_LAG-3 PF11498.8 CDI81287.1 - 0.0068 15.4 20.1 0.0068 15.4 20.1 3.7 4 0 0 4 4 4 1 Transcriptional activator LAG-3 Connexin PF00029.19 CDI81287.1 - 0.18 11.5 9.2 2.7 7.7 2.4 3.0 3 0 0 3 3 3 0 Connexin EOS1 PF12326.8 CDI81287.1 - 0.2 11.5 14.9 0.92 9.4 0.9 3.6 3 1 0 3 3 3 0 N-glycosylation protein DUF4746 PF15928.5 CDI81287.1 - 1.3 8.4 7.8 1.3 8.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF2721 PF11026.8 CDI81287.1 - 6.6 6.6 11.0 0.24 11.3 2.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Metallophos PF00149.28 CDI81289.1 - 3.7e-21 76.6 0.0 6e-20 72.6 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Isochorismatase PF00857.20 CDI81290.1 - 2e-12 47.7 0.0 3.4e-12 46.9 0.0 1.4 1 1 0 1 1 1 1 Isochorismatase family ABC_tran PF00005.27 CDI81291.1 - 4.8e-21 75.7 0.0 6.4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 CDI81291.1 - 0.00018 21.4 0.0 0.00032 20.6 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDI81291.1 - 0.00022 21.7 0.5 0.00028 21.3 0.0 1.6 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 CDI81291.1 - 0.00024 21.4 0.0 0.00036 20.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDI81291.1 - 0.00076 20.0 0.1 0.0012 19.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDI81291.1 - 0.0035 17.4 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Rad17 PF03215.15 CDI81291.1 - 0.0039 17.1 0.0 0.0061 16.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_28 PF13521.6 CDI81291.1 - 0.0068 16.7 1.3 0.012 15.9 0.1 2.0 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDI81291.1 - 0.01 15.4 0.3 0.021 14.4 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDI81291.1 - 0.018 15.1 0.0 0.056 13.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDI81291.1 - 0.024 15.2 0.0 0.033 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDI81291.1 - 0.028 14.2 1.1 0.042 13.6 0.1 1.8 2 0 0 2 2 1 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 CDI81291.1 - 0.03 14.2 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 CDI81291.1 - 0.031 14.0 0.6 0.066 13.0 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 CDI81291.1 - 0.031 14.3 0.1 0.048 13.7 0.0 1.4 2 0 0 2 2 1 0 Dynamin family FeoB_N PF02421.18 CDI81291.1 - 0.033 13.7 0.0 0.067 12.7 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B NACHT PF05729.12 CDI81291.1 - 0.044 13.7 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 NACHT domain AAA_35 PF14516.6 CDI81291.1 - 0.076 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_24 PF13479.6 CDI81291.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDI81291.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NB-ARC PF00931.22 CDI81291.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 CDI81291.1 - 0.13 12.5 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 CDI81291.1 - 0.14 11.5 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 CDI81291.1 - 0.17 11.0 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SRPRB PF09439.10 CDI81291.1 - 0.18 11.2 0.1 0.37 10.2 0.1 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.19 CDI81291.1 - 0.19 11.3 0.7 0.25 10.9 0.0 1.5 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 CDI81291.1 - 0.2 12.1 0.1 0.3 11.5 0.1 1.5 1 1 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 CDI81291.1 - 0.39 10.3 0.0 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NolX PF05819.11 CDI81291.1 - 5.2 6.3 0.0 5.2 6.3 0.0 2.1 2 0 0 2 2 1 0 NolX protein CCSAP PF15748.5 CDI81299.1 - 0.0095 16.1 21.3 0.0095 16.1 21.3 4.8 2 1 2 4 4 4 1 Centriole, cilia and spindle-associated Acetyltransf_11 PF13720.6 CDI81299.1 - 0.48 10.9 6.5 4.1 7.9 0.7 4.9 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DER1 PF04511.15 CDI81301.1 - 2.8e-08 33.9 0.1 0.00033 20.6 0.1 2.2 2 0 0 2 2 2 2 Der1-like family Velvet PF11754.8 CDI81301.1 - 0.0041 17.1 7.6 0.16 11.9 0.4 2.1 2 0 0 2 2 2 2 Velvet factor CLN3 PF02487.17 CDI81301.1 - 0.04 13.0 0.7 0.31 10.0 0.0 2.1 2 0 0 2 2 2 0 CLN3 protein EOS1 PF12326.8 CDI81301.1 - 0.11 12.5 1.1 11 6.0 0.1 2.5 2 0 0 2 2 2 0 N-glycosylation protein Pex14_N PF04695.13 CDI81301.1 - 0.12 13.0 7.2 2 9.0 2.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPX PF03105.19 CDI81301.1 - 0.16 11.9 19.2 0.66 9.8 19.4 1.9 1 1 1 2 2 2 0 SPX domain DUF1980 PF09323.10 CDI81301.1 - 0.94 9.4 2.8 19 5.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Kei1 PF08552.11 CDI81301.1 - 4.5 7.1 7.2 0.49 10.2 0.2 2.2 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Thioredoxin PF00085.20 CDI81302.1 - 9.2e-44 147.6 0.2 2.8e-31 107.5 0.3 2.7 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CDI81302.1 - 5.8e-09 36.1 0.0 0.00075 19.5 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_3 PF13192.6 CDI81302.1 - 1.2e-08 34.8 0.1 0.0019 18.2 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin domain OST3_OST6 PF04756.13 CDI81302.1 - 1.8e-08 34.1 0.1 5.8e-05 22.6 0.0 2.6 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CDI81302.1 - 6.6e-07 29.8 0.1 0.019 15.4 0.2 2.9 2 1 0 2 2 2 2 Thioredoxin-like domain TraF PF13728.6 CDI81302.1 - 3.4e-05 23.8 0.0 0.0023 17.8 0.0 2.3 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 CDI81302.1 - 4.6e-05 23.7 0.0 0.84 10.0 0.0 4.0 2 2 2 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.6 CDI81302.1 - 0.00043 20.4 0.2 0.14 12.3 0.1 2.5 2 0 0 2 2 2 1 Thioredoxin-like HyaE PF07449.11 CDI81302.1 - 0.023 14.6 0.0 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 CDI81302.1 - 0.051 13.5 0.2 13 5.7 0.0 2.4 2 0 0 2 2 2 0 AhpC/TSA family Thioredoxin_9 PF14595.6 CDI81302.1 - 0.13 12.1 0.0 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin SR-25 PF10500.9 CDI81302.1 - 0.5 9.9 7.1 0.73 9.4 7.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CorA PF01544.18 CDI81303.1 - 0.0044 16.4 2.9 0.0084 15.5 2.9 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Prefoldin PF02996.17 CDI81303.1 - 0.011 15.7 3.4 0.03 14.2 3.4 1.8 1 0 0 1 1 1 0 Prefoldin subunit NPV_P10 PF05531.12 CDI81303.1 - 0.027 14.9 2.3 1.9 9.0 2.3 3.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ApoLp-III PF07464.11 CDI81303.1 - 0.031 14.4 2.3 0.094 12.8 2.3 1.8 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) CdvA PF18822.1 CDI81303.1 - 0.047 13.5 2.6 0.11 12.3 2.6 1.6 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Gp-FAR-1 PF05823.12 CDI81303.1 - 0.06 13.7 0.7 0.12 12.7 0.7 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1664 PF07889.12 CDI81303.1 - 0.07 13.2 1.5 0.25 11.4 1.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 CDI81303.1 - 0.11 13.2 9.3 0.064 13.9 5.9 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) FUSC PF04632.12 CDI81303.1 - 0.14 10.6 12.3 0.36 9.3 12.3 1.6 1 0 0 1 1 1 0 Fusaric acid resistance protein family PIN_8 PF18476.1 CDI81303.1 - 0.17 11.7 4.3 0.44 10.4 1.6 2.1 2 0 0 2 2 2 0 PIN like domain Laminin_II PF06009.12 CDI81303.1 - 0.18 11.8 1.7 0.67 10.0 1.6 2.0 2 0 0 2 2 2 0 Laminin Domain II Fib_alpha PF08702.10 CDI81303.1 - 0.27 11.4 2.0 1.1 9.4 0.2 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Apolipoprotein PF01442.18 CDI81303.1 - 0.28 11.0 21.0 0.21 11.5 16.3 2.7 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Spc7 PF08317.11 CDI81303.1 - 0.41 9.5 6.1 0.75 8.6 6.1 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4795 PF16043.5 CDI81303.1 - 0.86 9.2 7.2 1.8 8.1 7.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) YtxH PF12732.7 CDI81303.1 - 1.4 9.5 3.6 1.6 9.3 0.8 1.9 1 1 1 2 2 2 0 YtxH-like protein DUF4407 PF14362.6 CDI81303.1 - 5.7 6.2 9.7 10 5.4 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 CDI81303.1 - 6.9 6.7 7.3 6 6.9 1.1 3.4 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus E1_UFD PF09358.10 CDI81304.1 - 0.022 15.5 0.0 0.03 15.0 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin fold domain DUF2722 PF10846.8 CDI81306.1 - 0.0023 17.0 1.6 0.0023 17.0 1.6 3.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) Velvet PF11754.8 CDI81306.1 - 0.61 10.0 14.9 2.9 7.8 0.3 2.5 2 0 0 2 2 2 0 Velvet factor PAT1 PF09770.9 CDI81306.1 - 4.1 5.6 40.0 0.29 9.3 26.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 GDA1_CD39 PF01150.17 CDI81307.1 - 1.5e-41 142.5 0.0 4.5e-37 127.7 0.0 2.5 2 1 0 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family BRCT_2 PF16589.5 CDI81308.1 - 0.021 15.2 0.0 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Phage_holin_2_3 PF16080.5 CDI81309.1 - 0.003 17.3 1.1 0.018 14.8 1.1 2.3 1 1 0 1 1 1 1 Bacteriophage holin family HP1 CobD_Cbib PF03186.13 CDI81309.1 - 0.069 12.4 3.0 0.087 12.0 2.1 1.5 1 1 1 2 2 2 0 CobD/Cbib protein Titin_Z PF09042.11 CDI81310.1 - 0.082 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Titin Z Glyoxalase_5 PF14696.6 CDI81310.1 - 0.11 12.7 0.1 1.9 8.7 0.1 2.2 2 0 0 2 2 2 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal RRM_1 PF00076.22 CDI81311.1 - 1.1e-14 54.0 0.0 1.8e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tail_spike_N PF18668.1 CDI81312.1 - 0.061 13.2 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain Ctr PF04145.15 CDI81313.1 - 1.4e-09 38.7 2.0 1.7e-09 38.5 2.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family GLTP PF08718.11 CDI81314.1 - 1.2e-14 54.9 0.0 1.5e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) UQ_con PF00179.26 CDI81316.1 - 4e-45 152.9 0.0 4.9e-45 152.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI81316.1 - 0.086 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 CDI81316.1 - 0.27 11.5 1.3 0.58 10.5 1.2 1.6 1 1 0 1 1 1 0 RWD domain SNF2_N PF00176.23 CDI81317.1 - 1.3e-43 149.1 0.8 5.6e-24 84.5 0.0 4.3 4 0 0 4 4 4 4 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI81317.1 - 2.2e-16 60.2 0.0 7.4e-16 58.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 CDI81317.1 - 6.6e-07 29.6 1.1 6.6e-07 29.6 1.1 2.5 3 0 0 3 3 1 1 Ring finger domain zf-PARP PF00645.18 CDI81317.1 - 9.1e-06 26.5 0.0 4.9e-05 24.1 0.0 2.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-RING_UBOX PF13445.6 CDI81317.1 - 2e-05 24.5 0.3 7e-05 22.8 0.3 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 CDI81317.1 - 2.1e-05 24.7 1.3 0.0001 22.5 1.0 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain DEAD PF00270.29 CDI81317.1 - 0.00012 21.9 0.0 0.013 15.3 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.25 CDI81317.1 - 0.00053 19.8 1.8 0.00053 19.8 1.8 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDI81317.1 - 0.00098 18.8 2.0 0.00098 18.8 2.0 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI81317.1 - 0.0019 18.0 1.8 0.0019 18.0 1.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDI81317.1 - 0.0024 17.9 0.2 0.0073 16.3 0.2 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PyrI_C PF02748.15 CDI81317.1 - 0.035 14.0 0.2 0.088 12.7 0.2 1.7 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-HC5HC2H PF13771.6 CDI81317.1 - 0.072 13.3 2.8 0.13 12.6 0.7 2.6 2 0 0 2 2 2 0 PHD-like zinc-binding domain FANCL_C PF11793.8 CDI81317.1 - 0.23 11.7 1.5 0.39 10.9 0.3 2.1 2 0 0 2 2 1 0 FANCL C-terminal domain Reticulon PF02453.17 CDI81318.1 - 3.9e-11 43.2 7.7 4e-11 43.1 6.6 1.5 1 1 1 2 2 2 1 Reticulon UQ_con PF00179.26 CDI81320.1 - 2.4e-15 56.4 0.0 3.5e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDI81320.1 - 0.093 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain Vps36-NZF-N PF16988.5 CDI81320.1 - 0.12 11.8 0.1 0.25 10.7 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CBM_48 PF02922.18 CDI81321.1 - 1.8e-21 76.3 0.0 2.2e-20 72.8 0.0 2.9 4 0 0 4 4 4 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 CDI81321.1 - 1.5e-19 70.2 0.0 9.5e-19 67.7 0.0 2.3 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 CDI81321.1 - 4e-14 52.9 0.6 1.8e-05 24.5 0.1 3.1 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CDI81321.1 - 0.0071 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain PDEase_I PF00233.19 CDI81322.1 - 6e-60 202.9 5.8 9.9e-30 104.0 0.0 2.2 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase RCC1_2 PF13540.6 CDI81323.1 - 5e-13 48.5 21.2 3.6e-05 23.5 0.1 5.7 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 CDI81323.1 - 1.2e-12 48.2 15.0 0.0019 18.8 2.1 7.2 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat WD40 PF00400.32 CDI81325.1 - 6.5e-10 39.5 7.3 0.00053 20.7 0.6 4.7 4 1 1 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI81325.1 - 5.1e-05 23.5 0.0 1.1 9.6 0.0 4.2 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_1 PF00036.32 CDI81325.1 - 0.0033 16.9 0.0 0.0082 15.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDI81325.1 - 0.16 12.0 0.0 0.44 10.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain PQQ_3 PF13570.6 CDI81325.1 - 2 9.0 5.1 2.9 8.5 0.0 3.7 5 0 0 5 5 5 0 PQQ-like domain OB_NTP_bind PF07717.16 CDI81327.1 - 1e-16 61.1 0.0 2.9e-16 59.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDI81327.1 - 1.3e-13 51.3 0.3 1.3e-12 48.1 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 CDI81327.1 - 7.9e-10 39.0 0.0 7.9e-10 39.0 0.0 5.5 5 1 0 5 5 4 1 Helicase associated domain (HA2) DEAD PF00270.29 CDI81327.1 - 7e-07 29.2 0.1 2.3e-06 27.5 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDI81327.1 - 5.6e-06 26.7 0.2 4.7e-05 23.7 0.0 2.8 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 CDI81327.1 - 0.0068 16.3 2.7 0.016 15.2 0.6 2.7 3 0 0 3 3 3 1 NACHT domain T2SSE PF00437.20 CDI81327.1 - 0.011 14.9 0.0 0.026 13.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein EIN3 PF04873.13 CDI81327.1 - 0.11 11.8 9.5 0.024 13.9 3.3 2.5 2 0 0 2 2 2 0 Ethylene insensitive 3 DUF2828 PF11443.8 CDI81327.1 - 0.9 7.5 14.2 0.12 10.5 9.2 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF2828) CDC45 PF02724.14 CDI81327.1 - 1.3 7.2 10.7 5.7 5.1 10.7 2.0 1 1 0 1 1 1 0 CDC45-like protein AAA_23 PF13476.6 CDI81327.1 - 3 8.3 0.0 3 8.3 0.0 4.4 4 1 0 4 4 3 0 AAA domain RskA PF10099.9 CDI81328.1 - 0.89 9.8 58.7 0.06 13.6 2.1 7.0 4 1 1 5 5 5 0 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI81328.1 - 1.3 9.5 4.3 63 4.1 4.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) SPRY PF00622.28 CDI81329.1 - 0.0022 18.1 0.0 0.032 14.4 0.0 3.2 1 0 0 1 1 1 1 SPRY domain Helicase_C PF00271.31 CDI81330.1 - 4.3e-10 39.9 0.0 6.4e-09 36.1 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 CDI81330.1 - 1.2e-09 38.4 0.0 1.2e-09 38.4 0.0 5.0 5 1 0 5 5 5 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI81330.1 - 0.016 15.5 0.0 0.044 14.2 0.0 1.8 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 CDI81330.1 - 0.14 12.5 1.4 13 6.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 CDI81330.1 - 0.21 10.9 4.4 1.6 8.0 0.0 3.2 4 0 0 4 4 4 0 FtsK/SpoIIIE family HSP90 PF00183.18 CDI81331.1 - 6.4e-104 348.7 0.1 2.3e-99 333.7 0.0 2.6 2 1 1 3 3 3 2 Hsp90 protein HATPase_c_3 PF13589.6 CDI81331.1 - 1e-09 38.3 0.0 2.2e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDI81331.1 - 7.7e-09 36.1 0.0 1.9e-08 34.8 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2183 PF09949.9 CDI81331.1 - 0.059 13.7 0.1 18 5.7 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) Ribosomal_60s PF00428.19 CDI81331.1 - 3.6 8.2 13.3 1.2 9.8 4.4 3.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein Methyltransf_15 PF09445.10 CDI81332.1 - 5.5e-24 84.6 0.0 8.8e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 CDI81332.1 - 0.0027 17.4 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 CDI81332.1 - 0.0033 18.1 0.0 0.0097 16.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI81332.1 - 0.16 12.6 0.0 0.64 10.7 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain CRAL_TRIO PF00650.20 CDI81334.1 - 0.02 14.6 0.1 0.033 13.9 0.1 1.4 1 1 0 1 1 1 0 CRAL/TRIO domain RskA PF10099.9 CDI81335.1 - 0.015 15.6 7.5 0.015 15.6 7.5 2.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA LAP1C PF05609.12 CDI81335.1 - 7.3 5.6 34.8 7.7 5.5 34.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SNF2_N PF00176.23 CDI81336.1 - 5e-09 35.3 0.0 5e-09 35.3 0.0 4.3 3 2 0 3 3 3 2 SNF2 family N-terminal domain RskA PF10099.9 CDI81336.1 - 5.2e-05 23.6 0.1 5.2e-05 23.6 0.1 15.4 3 2 5 10 10 10 3 Anti-sigma-K factor rskA DUF4667 PF15700.5 CDI81336.1 - 0.0031 17.6 0.0 0.0031 17.6 0.0 6.8 5 3 2 7 7 7 1 Domain of unknown function (DUF4667) Presenilin PF01080.17 CDI81337.1 - 4.2 6.0 24.7 5 5.8 24.7 1.1 1 0 0 1 1 1 0 Presenilin RskA PF10099.9 CDI81339.1 - 4.8e-05 23.7 0.7 4.8e-05 23.7 0.7 2.9 1 1 1 2 2 2 1 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI81339.1 - 0.04 12.5 9.0 0.058 12.0 9.0 1.1 1 0 0 1 1 1 0 Macoilin family FCP1_C PF09309.10 CDI81339.1 - 1.9 8.3 13.5 6.9 6.5 6.9 2.1 2 0 0 2 2 2 0 FCP1, C-terminal Connexin PF00029.19 CDI81339.1 - 3.1 7.5 7.2 4.8 6.9 7.2 1.2 1 0 0 1 1 1 0 Connexin LMBR1 PF04791.16 CDI81340.1 - 1.2 8.0 4.0 1.6 7.6 4.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF488 PF04343.13 CDI81340.1 - 1.4 9.5 6.2 0.31 11.6 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF488 Exonuc_VII_L PF02601.15 CDI81341.1 - 0.023 14.3 26.6 0.0077 15.8 21.7 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF572 PF04502.13 CDI81341.1 - 1.5 8.3 15.0 4.1 6.9 15.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF572) Coprogen_oxidas PF01218.18 CDI81341.1 - 3.8 6.1 7.0 6.8 5.3 7.0 1.3 1 0 0 1 1 1 0 Coproporphyrinogen III oxidase Spt20 PF12090.8 CDI81342.1 - 2.7 7.5 11.1 3.5 7.2 11.1 1.3 1 0 0 1 1 1 0 Spt20 family Cwf_Cwc_15 PF04889.12 CDI81343.1 - 2.7e-10 40.4 30.2 1.3e-09 38.2 7.6 2.9 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein Suf PF05843.14 CDI81343.1 - 2.1 8.3 6.7 3.2 7.7 6.7 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EMP24_GP25L PF01105.24 CDI81344.1 - 0.0013 18.7 0.0 0.0016 18.5 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Humanin PF15040.6 CDI81344.1 - 4.5 6.8 9.4 11 5.6 6.3 2.8 2 1 0 2 2 2 0 Humanin family Pkinase_Tyr PF07714.17 CDI81353.1 - 2.3e-05 23.8 0.0 4.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDI81353.1 - 0.072 12.4 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain Ribosomal_60s PF00428.19 CDI81353.1 - 1.5 9.4 28.9 0.04 14.5 4.5 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI81353.1 - 6.5 6.6 28.2 0.023 14.7 7.1 3.1 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Guanylate_cyc_2 PF09778.9 CDI81364.1 - 6.6e-12 45.2 0.0 2.4e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Guanylylate cyclase Peptidase_C39 PF03412.15 CDI81364.1 - 0.0012 18.6 0.0 0.0031 17.3 0.0 1.7 2 0 0 2 2 2 1 Peptidase C39 family Spt20 PF12090.8 CDI81364.1 - 0.074 12.7 3.6 0.12 11.9 3.6 1.3 1 0 0 1 1 1 0 Spt20 family DUF5105 PF17118.5 CDI81366.1 - 0.083 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) Radical_SAM PF04055.21 CDI81367.1 - 0.0014 19.0 0.0 0.0021 18.4 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Pkinase_Tyr PF07714.17 CDI81368.1 - 0.00029 20.2 0.0 0.0034 16.7 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 CDI81368.1 - 0.017 14.5 0.0 0.053 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain DUF1840 PF08895.11 CDI81368.1 - 8.6 6.8 7.9 1.9 8.9 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF908 PF06012.12 CDI81369.1 - 9.3e-15 54.9 0.0 9.3e-15 54.9 0.0 22.9 19 8 3 23 23 23 1 Domain of Unknown Function (DUF908) UBM PF14377.6 CDI81369.1 - 3.7e-13 48.4 9.8 6.1e-10 38.2 2.3 9.7 5 1 1 6 6 6 2 Ubiquitin binding region UBA PF00627.31 CDI81369.1 - 3.2e-10 39.7 0.5 1.2e-09 37.9 0.5 2.2 1 0 0 1 1 1 1 UBA/TS-N domain Utp14 PF04615.13 CDI81369.1 - 1.1e-07 30.9 2.9 1.1e-07 30.9 2.9 18.1 10 5 5 17 17 17 4 Utp14 protein DUF913 PF06025.12 CDI81369.1 - 8.9e-06 24.9 0.0 8.9e-06 24.9 0.0 23.4 21 6 3 25 25 25 3 Domain of Unknown Function (DUF913) BUD22 PF09073.10 CDI81370.1 - 0.0012 18.3 10.6 0.002 17.5 10.6 1.3 1 0 0 1 1 1 1 BUD22 CDC45 PF02724.14 CDI81370.1 - 0.0026 16.1 4.4 0.0033 15.8 4.4 1.1 1 0 0 1 1 1 1 CDC45-like protein Vfa1 PF08432.10 CDI81370.1 - 0.0029 18.0 15.0 0.0047 17.3 15.0 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 FAM176 PF14851.6 CDI81370.1 - 0.014 15.0 5.0 0.026 14.2 5.0 1.4 1 0 0 1 1 1 0 FAM176 family Afi1 PF07792.12 CDI81370.1 - 0.031 14.7 8.1 0.05 14.1 8.1 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 CDI81370.1 - 0.036 13.8 2.2 0.067 12.9 2.2 1.4 1 0 0 1 1 1 0 Connexin Roughex PF06020.11 CDI81370.1 - 0.063 12.4 3.9 0.083 12.0 3.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Tim54 PF11711.8 CDI81370.1 - 0.066 12.0 5.7 0.096 11.5 5.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNA_pol_Rpc4 PF05132.14 CDI81370.1 - 0.16 12.4 8.5 0.27 11.7 8.5 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2722 PF10846.8 CDI81370.1 - 0.34 9.8 14.0 0.49 9.3 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) V_ATPase_I PF01496.19 CDI81370.1 - 0.36 8.7 2.1 0.53 8.1 2.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 CDI81370.1 - 0.42 9.8 6.1 0.63 9.2 6.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SpoIIP PF07454.11 CDI81370.1 - 0.57 9.6 7.8 0.49 9.8 6.7 1.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DNA_pol_phi PF04931.13 CDI81370.1 - 0.75 7.8 21.8 1.1 7.2 21.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi RPN2_C PF18004.1 CDI81370.1 - 0.77 9.7 16.8 1.2 9.0 16.8 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TFB6 PF17110.5 CDI81370.1 - 0.77 9.5 9.8 1.5 8.6 9.8 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH MAP17 PF15807.5 CDI81370.1 - 1.5 9.0 4.7 2.8 8.2 4.7 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GNAT_acetyltr_2 PF13718.6 CDI81370.1 - 1.6 8.1 3.9 57 3.0 5.0 2.2 2 0 0 2 2 2 0 GNAT acetyltransferase 2 DUF2076 PF09849.9 CDI81370.1 - 2 8.4 11.0 3.2 7.7 11.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) U79_P34 PF03064.16 CDI81370.1 - 2.4 7.5 19.0 4.9 6.4 17.6 1.9 2 0 0 2 2 2 0 HSV U79 / HCMV P34 COPI_C PF06957.11 CDI81370.1 - 8.3 5.1 10.2 13 4.4 0.0 2.2 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus K_channel_TID PF07941.11 CDI81379.1 - 0.0048 17.3 9.5 0.0048 17.3 9.5 12.7 9 5 1 10 10 10 1 Potassium channel Kv1.4 tandem inactivation domain CBM_20 PF00686.19 CDI81380.1 - 4.6e-11 42.5 3.3 7.4e-11 41.8 0.0 2.3 2 0 0 2 2 2 1 Starch binding domain SR-25 PF10500.9 CDI81380.1 - 0.048 13.3 20.5 0.065 12.8 20.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI81380.1 - 0.62 9.9 20.2 0.8 9.6 20.2 1.1 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 CDI81380.1 - 0.72 8.5 20.2 0.86 8.2 20.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PNISR PF15996.5 CDI81380.1 - 4.3 7.6 30.2 6.5 7.0 30.2 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SLC12 PF03522.15 CDI81380.1 - 5.7 5.9 18.5 8.5 5.3 18.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_C13 PF01650.18 CDI81384.1 - 2e-27 96.3 0.5 1e-17 64.5 0.2 3.1 2 1 1 3 3 3 2 Peptidase C13 family EIF4E-T PF10477.9 CDI81384.1 - 0.0025 16.7 3.9 0.0025 16.7 3.9 4.2 2 1 1 4 4 4 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF3292 PF11696.8 CDI81384.1 - 1.3 7.3 21.5 0.0095 14.4 8.7 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3292) SpoIIP PF07454.11 CDI81384.1 - 7.6 5.9 25.9 0.13 11.7 9.6 3.9 4 0 0 4 4 4 0 Stage II sporulation protein P (SpoIIP) VID27 PF08553.10 CDI81385.1 - 9.2e-11 41.4 0.2 1e-10 41.3 0.2 1.0 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain DUF5051 PF16473.5 CDI81386.1 - 0.094 12.7 0.2 0.32 11.0 0.2 1.9 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like eIF-5_eIF-2B PF01873.17 CDI81388.1 - 4.5e-36 123.3 0.0 9.1e-36 122.3 0.0 1.5 2 0 0 2 2 2 1 Domain found in IF2B/IF5 CPW_WPC PF09717.10 CDI81390.1 - 0.00055 20.8 0.1 0.00055 20.8 0.1 1.7 2 0 0 2 2 2 1 Plasmodium falciparum domain of unknown function (CPW_WPC) TPPII_N PF12583.8 CDI81390.1 - 2.2 8.8 14.7 3 8.4 14.7 1.1 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Na_Ca_ex PF01699.24 CDI81391.1 - 1.1e-14 54.6 16.3 1.1e-14 54.6 16.3 1.6 1 1 1 2 2 2 2 Sodium/calcium exchanger protein Nop14 PF04147.12 CDI81393.1 - 3e-05 22.5 62.7 0.00083 17.7 7.8 3.3 3 0 0 3 3 3 3 Nop14-like family DUF2722 PF10846.8 CDI81393.1 - 3.1e-05 23.1 15.6 3.1e-05 23.1 15.6 4.2 4 0 0 4 4 3 1 Protein of unknown function (DUF2722) BSP_II PF05432.11 CDI81393.1 - 0.00036 20.3 10.7 0.00036 20.3 10.7 4.3 3 1 1 4 4 3 2 Bone sialoprotein II (BSP-II) DUF2052 PF09747.9 CDI81393.1 - 0.0059 16.8 10.3 0.0059 16.8 10.3 3.6 3 1 0 3 3 2 1 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 CDI81393.1 - 0.078 11.3 63.2 0.011 14.0 8.2 3.1 3 0 0 3 3 3 0 CDC45-like protein DUF2207 PF09972.9 CDI81393.1 - 0.27 10.0 3.7 1.7 7.3 0.0 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF913 PF06025.12 CDI81393.1 - 0.79 8.6 36.5 0.66 8.9 8.6 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 CDI81393.1 - 0.87 7.9 0.0 0.87 7.9 0.0 3.5 2 1 0 3 3 2 0 dsRNA-gated channel SID-1 Zip PF02535.22 CDI81393.1 - 1.1 8.4 29.4 0.22 10.7 2.8 3.7 3 0 0 3 3 3 0 ZIP Zinc transporter Tim54 PF11711.8 CDI81393.1 - 2 7.1 58.0 0.84 8.4 19.4 3.2 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 Mpp10 PF04006.12 CDI81393.1 - 5.5 5.3 80.7 0.032 12.7 11.9 3.1 3 0 0 3 3 3 0 Mpp10 protein Rrp15p PF07890.12 CDI81395.1 - 4.1e-06 27.2 6.1 4.1e-06 27.2 6.1 4.9 1 1 2 3 3 3 1 Rrp15p Helicase_C PF00271.31 CDI81396.1 - 8.9e-33 113.0 0.0 3.3e-32 111.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI81396.1 - 4e-16 59.3 1.2 6.7e-13 48.8 0.0 2.7 2 1 1 3 3 3 2 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 CDI81396.1 - 0.029 13.6 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF72 PF01904.18 CDI81396.1 - 0.049 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF72 SPX PF03105.19 CDI81397.1 - 0.002 18.2 2.1 0.0022 18.0 2.1 1.0 1 0 0 1 1 1 1 SPX domain DSS1_SEM1 PF05160.13 CDI81397.1 - 0.019 15.0 4.8 0.019 15.0 4.8 2.2 1 1 1 2 2 2 0 DSS1/SEM1 family DEAD PF00270.29 CDI81398.1 - 2.4e-35 121.9 0.0 5.6e-35 120.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI81398.1 - 2.3e-17 63.3 0.0 1.5e-16 60.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DSPc PF00782.20 CDI81398.1 - 3e-07 30.3 0.0 6.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CBM_20 PF00686.19 CDI81398.1 - 0.023 14.6 0.4 0.25 11.3 0.0 2.7 3 0 0 3 3 3 0 Starch binding domain DUF4050 PF13259.6 CDI81398.1 - 4.6 7.5 10.4 0.69 10.2 2.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Ribosomal_L22e PF01776.17 CDI81399.1 - 3e-45 153.1 2.3 3.5e-45 152.9 2.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family AMPK1_CBM PF16561.5 CDI81399.1 - 0.032 14.4 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Glycogen recognition site of AMP-activated protein kinase pP_pnuc_1 PF18165.1 CDI81399.1 - 0.067 13.1 0.6 9.9 6.1 0.2 2.1 1 1 1 2 2 2 0 Predicted pPIWI-associating nuclease DUF3228 PF11539.8 CDI81400.1 - 4e-35 121.1 0.1 1.8e-28 99.4 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3228) eIF3_p135 PF12807.7 CDI81402.1 - 1.6e-08 34.8 0.1 4.6e-08 33.3 0.1 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 PWI PF01480.17 CDI81403.1 - 1.4e-28 98.9 0.0 2.4e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 PWI domain PYC_OADA PF02436.18 CDI81403.1 - 0.0099 15.6 0.1 0.018 14.8 0.1 1.3 1 1 0 1 1 1 1 Conserved carboxylase domain CALM_bind PF16025.5 CDI81403.1 - 0.032 14.7 0.6 0.07 13.6 0.6 1.5 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding PhoD PF09423.10 CDI81405.1 - 4.8e-11 42.3 1.4 1e-09 37.9 0.2 2.2 2 0 0 2 2 2 2 PhoD-like phosphatase TerD PF02342.18 CDI81406.1 - 1.4e-05 24.7 0.0 5.8e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 TerD domain Fer4_24 PF18109.1 CDI81406.1 - 0.02 15.1 0.4 0.11 12.8 0.1 2.1 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain Spc7 PF08317.11 CDI81406.1 - 0.067 12.1 2.4 0.12 11.3 2.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 CDI81406.1 - 0.086 10.3 2.5 0.12 9.9 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Apolipoprotein PF01442.18 CDI81406.1 - 0.14 12.0 6.0 0.5 10.2 5.5 2.0 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Vac_Fusion PF02346.16 CDI81406.1 - 0.71 9.5 1.9 43 3.8 0.0 3.1 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 DUF2205 PF10224.9 CDI81406.1 - 2.3 8.3 6.8 11 6.1 1.0 3.1 2 1 1 3 3 3 0 Short coiled-coil protein T3SS_LEE_assoc PF13327.6 CDI81410.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 Type III secretion system subunit Ribosomal_60s PF00428.19 CDI81412.1 - 7.3 7.3 8.3 18 6.0 5.2 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein zf-met PF12874.7 CDI81415.1 - 0.00019 21.7 1.4 0.00036 20.8 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDI81415.1 - 0.00041 20.6 1.5 0.0008 19.6 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF3381 PF11861.8 CDI81415.1 - 0.003 17.4 1.0 0.0045 16.8 1.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3381) SARAF PF06682.12 CDI81415.1 - 0.096 12.3 2.6 0.1 12.2 2.6 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DinB_2 PF12867.7 CDI81415.1 - 0.38 11.3 2.0 10 6.6 2.0 2.2 1 1 0 1 1 1 0 DinB superfamily DASH_Spc19 PF08287.11 CDI81415.1 - 0.5 10.2 4.2 0.71 9.7 1.5 1.9 2 0 0 2 2 2 0 Spc19 DUF4407 PF14362.6 CDI81415.1 - 4.7 6.5 8.0 6.5 6.0 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Effector_1 PF04518.12 CDI81417.1 - 0.0062 15.7 2.2 0.012 14.8 2.2 1.4 1 0 0 1 1 1 1 Effector from type III secretion system MRP-L51 PF10244.9 CDI81417.1 - 0.2 11.9 0.4 4 7.7 0.0 2.8 2 2 0 2 2 2 0 Mitochondrial ribosomal subunit Hemerythrin PF01814.23 CDI81417.1 - 0.43 11.2 9.0 0.13 12.9 4.4 2.4 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain HALZ PF02183.18 CDI81417.1 - 0.83 9.9 13.1 2.4 8.5 0.3 3.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper PHM7_cyt PF14703.6 CDI81417.1 - 7 6.8 8.3 3.4 7.9 0.3 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RNA_pol_Rpb1_5 PF04998.17 CDI81418.1 - 5e-16 58.9 0.1 5e-16 58.9 0.1 1.4 1 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 SseC PF04888.12 CDI81418.1 - 0.53 9.8 12.8 0.93 9.0 12.8 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF4781 PF16013.5 CDI81418.1 - 0.55 9.0 4.6 0.77 8.5 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) RNA_pol_Rpb1_5 PF04998.17 CDI81419.1 - 7.9e-32 110.7 0.0 9.5e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.17 CDI81419.1 - 4.9e-20 71.5 0.3 4.9e-20 71.5 0.3 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 Macoilin PF09726.9 CDI81419.1 - 1 7.8 16.4 1.4 7.3 16.4 1.2 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CDI81419.1 - 1.2 9.0 11.1 1.6 8.6 11.1 1.1 1 0 0 1 1 1 0 SPX domain PAP1 PF08601.10 CDI81419.1 - 4.4 6.9 19.4 6.2 6.4 19.4 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Apt1 PF10351.9 CDI81419.1 - 6 5.6 13.6 7.9 5.2 13.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-CCHC PF00098.23 CDI81420.1 - 1e-07 31.7 12.0 0.0013 18.7 3.1 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 CDI81420.1 - 0.043 13.6 6.0 0.64 9.8 0.4 2.6 2 0 0 2 2 2 0 Zinc knuckle DnaJ_CXXCXGXG PF00684.19 CDI81420.1 - 0.2 12.1 7.7 0.48 10.8 7.7 1.7 1 0 0 1 1 1 0 DnaJ central domain zf-CCHC_5 PF14787.6 CDI81420.1 - 0.37 10.5 6.4 2.2 8.0 1.0 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 CDI81420.1 - 4.7 7.1 9.2 5.4 6.9 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 CDI81420.1 - 4.7 7.1 8.8 12 5.9 2.3 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 CDI81420.1 - 9.3 6.3 11.8 0.5 10.4 2.1 2.5 1 1 1 2 2 2 0 Zinc knuckle RT_RNaseH PF17917.1 CDI81421.1 - 5.1e-19 68.5 0.0 1e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDI81421.1 - 2.4e-14 53.1 0.4 4.8e-14 52.2 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 CDI81421.1 - 5.8e-14 51.9 0.0 1.3e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVP_2 PF08284.11 CDI81421.1 - 7.4e-10 38.7 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI81421.1 - 4.5e-07 30.4 0.0 8.8e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI81421.1 - 1.3e-05 25.7 0.0 2.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 CDI81421.1 - 0.11 12.7 0.8 0.33 11.2 0.1 2.3 3 0 0 3 3 3 0 H2C2 zinc finger Asp_protease PF09668.10 CDI81421.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease PH PF00169.29 CDI81422.1 - 4.6e-06 27.1 0.0 8.4e-06 26.2 0.0 1.5 1 1 0 1 1 1 1 PH domain PH_16 PF17838.1 CDI81422.1 - 0.0082 16.0 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 CDI81422.1 - 0.0092 16.2 0.1 0.016 15.5 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain TPPII_N PF12583.8 CDI81422.1 - 0.017 15.7 5.4 2.4 8.7 3.7 2.2 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal PH_TFIIH PF08567.11 CDI81422.1 - 0.029 14.7 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain PBP1_TM PF14812.6 CDI81422.1 - 0.086 13.2 0.4 0.16 12.4 0.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-HC5HC2H_2 PF13832.6 CDI81423.1 - 4.2e-08 33.3 4.2 4.2e-08 33.3 4.2 5.7 6 1 1 7 7 7 1 PHD-zinc-finger like domain PHD PF00628.29 CDI81423.1 - 1.6e-07 31.1 16.0 1.1e-05 25.2 6.1 6.9 7 0 0 7 7 7 2 PHD-finger zf-HC5HC2H PF13771.6 CDI81423.1 - 6.7e-06 26.3 6.2 6.7e-06 26.3 6.2 5.9 4 2 0 4 4 4 1 PHD-like zinc-binding domain DUF755 PF05501.11 CDI81423.1 - 0.0017 18.6 17.3 0.0017 18.6 17.3 16.2 14 1 2 16 16 16 2 Domain of unknown function (DUF755) AIM3 PF17096.5 CDI81424.1 - 0.013 16.4 0.6 0.024 15.5 0.6 1.8 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 3 AAA PF00004.29 CDI81425.1 - 4.3e-53 179.2 0.0 5.4e-25 88.3 0.0 4.8 3 1 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI81425.1 - 7.4e-11 41.7 6.1 1.4e-06 27.9 0.3 3.2 3 0 0 3 3 2 2 AAA+ lid domain AAA_5 PF07728.14 CDI81425.1 - 2e-10 40.8 0.3 0.00011 22.3 0.0 4.1 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDI81425.1 - 2e-08 34.1 0.0 0.00022 21.0 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDI81425.1 - 4.4e-08 32.8 0.1 0.0031 16.9 0.1 3.0 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CDI81425.1 - 8.1e-07 29.4 0.0 0.043 14.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 CDI81425.1 - 2e-06 27.6 10.1 0.0055 16.5 0.1 3.9 4 1 1 5 5 3 2 IstB-like ATP binding protein AAA_22 PF13401.6 CDI81425.1 - 8.6e-06 26.1 12.9 0.013 15.8 0.0 5.5 4 2 0 4 4 4 2 AAA domain TIP49 PF06068.13 CDI81425.1 - 3.8e-05 23.1 0.0 0.14 11.4 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 CDI81425.1 - 5.6e-05 23.3 0.0 0.0042 17.2 0.0 6.5 6 2 0 7 7 4 2 AAA domain AAA_14 PF13173.6 CDI81425.1 - 0.00018 21.6 0.0 0.041 13.9 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CDI81425.1 - 0.00024 21.6 14.3 0.012 16.1 0.1 4.9 6 1 0 6 6 4 2 AAA domain AAA_25 PF13481.6 CDI81425.1 - 0.0003 20.4 0.0 0.61 9.6 0.0 3.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 CDI81425.1 - 0.00051 20.0 6.3 0.18 11.7 0.0 4.6 4 1 0 4 4 4 2 NACHT domain TsaE PF02367.17 CDI81425.1 - 0.00062 19.8 0.0 0.28 11.2 0.0 3.2 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CDI81425.1 - 0.00068 20.1 16.0 0.0021 18.5 3.0 7.5 4 3 1 5 5 3 2 AAA ATPase domain Viral_helicase1 PF01443.18 CDI81425.1 - 0.00073 19.3 0.1 0.053 13.3 0.0 3.5 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 CDI81425.1 - 0.0016 18.4 0.1 0.38 10.7 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_24 PF13479.6 CDI81425.1 - 0.0021 17.8 6.3 0.26 11.0 0.0 4.0 4 0 0 4 4 2 2 AAA domain AAA_3 PF07726.11 CDI81425.1 - 0.0022 17.8 0.0 0.22 11.4 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDI81425.1 - 0.0025 17.4 0.1 3 7.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region SPX PF03105.19 CDI81425.1 - 0.0051 16.8 1.4 0.0051 16.8 1.4 4.6 3 2 1 4 4 3 2 SPX domain SR-25 PF10500.9 CDI81425.1 - 0.0063 16.2 18.0 0.0063 16.2 18.0 7.8 7 1 1 8 8 8 1 Nuclear RNA-splicing-associated protein AAA_2 PF07724.14 CDI81425.1 - 0.0096 16.0 12.6 0.01 16.0 0.0 4.8 5 1 0 5 5 3 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CDI81425.1 - 0.035 14.4 0.0 0.035 14.4 0.0 6.4 7 1 1 8 8 6 0 AAA domain Vps4_C PF09336.10 CDI81425.1 - 0.038 14.0 0.4 2.9 7.9 0.0 3.3 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain NTPase_1 PF03266.15 CDI81425.1 - 0.064 13.2 0.0 19 5.1 0.0 2.8 2 0 0 2 2 2 0 NTPase MMR_HSR1 PF01926.23 CDI81425.1 - 0.15 12.1 0.0 22 5.2 0.0 3.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Parvo_NS1 PF01057.17 CDI81425.1 - 0.27 10.3 6.0 0.47 9.5 0.0 3.1 3 0 0 3 3 2 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 CDI81425.1 - 0.38 11.2 11.6 1.6 9.2 0.0 5.1 4 1 1 5 5 4 0 AAA domain Hpr_kinase_C PF07475.12 CDI81425.1 - 0.5 9.9 2.6 2.4 7.6 0.0 3.1 4 0 0 4 4 2 0 HPr Serine kinase C-terminal domain MMR1 PF08505.10 CDI81425.1 - 1.2 9.4 87.7 0.2 11.9 8.2 6.2 6 0 0 6 6 6 0 Mitochondrial Myo2 receptor-related protein WD40 PF00400.32 CDI81426.1 - 2.5e-37 126.2 26.1 2.9e-07 31.0 0.3 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI81426.1 - 1.6e-14 54.0 7.0 0.041 14.2 0.1 5.8 3 3 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 CDI81426.1 - 0.00018 21.0 0.7 0.00063 19.2 0.2 2.2 3 0 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 CDI81426.1 - 0.0002 20.4 1.5 0.27 10.1 0.2 3.8 3 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 CDI81426.1 - 0.0016 17.6 0.4 1.1 8.2 0.1 2.8 3 0 0 3 3 3 2 Coatomer WD associated region DUF2722 PF10846.8 CDI81426.1 - 0.0029 16.6 9.3 0.013 14.5 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI81426.1 - 0.0077 15.9 18.9 0.059 13.0 5.1 2.3 2 0 0 2 2 2 2 Spt20 family RAB3GAP2_N PF14655.6 CDI81426.1 - 0.053 12.8 6.3 0.65 9.2 1.1 2.6 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Lactonase PF10282.9 CDI81426.1 - 0.082 12.2 3.7 2.4 7.3 0.2 3.2 3 1 0 3 3 3 0 Lactonase, 7-bladed beta-propeller TMEM51 PF15345.6 CDI81426.1 - 0.18 11.6 6.5 0.14 12.0 0.7 2.4 2 0 0 2 2 2 0 Transmembrane protein 51 PEX11 PF05648.14 CDI81426.1 - 0.55 9.7 3.1 0.73 9.2 0.1 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) SUIM_assoc PF16619.5 CDI81426.1 - 0.65 10.1 28.3 2.2 8.4 10.6 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 EPL1 PF10513.9 CDI81426.1 - 2 8.8 8.0 1.4 9.3 1.1 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Calc_CGRP_IAPP PF00214.19 CDI81426.1 - 2.3 8.6 4.7 2 8.8 0.0 2.5 1 1 1 2 2 2 0 Calcitonin / CGRP / IAPP family Presenilin PF01080.17 CDI81426.1 - 2.8 6.6 9.4 0.078 11.7 3.4 1.4 2 0 0 2 2 2 0 Presenilin TFIIIC_delta PF12657.7 CDI81426.1 - 3.9 7.4 12.5 3.2e+02 1.1 0.0 3.7 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Rpp20 PF12328.8 CDI81426.1 - 4.4 7.3 7.9 15 5.5 1.0 2.3 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P DUF4834 PF16118.5 CDI81426.1 - 5.1 8.1 12.1 6.3 7.8 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ANAPC_CDC26 PF10471.9 CDI81426.1 - 7.7 7.4 27.1 2.1 9.2 5.6 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 HSP70 PF00012.20 CDI81427.1 - 9.2e-17 60.4 52.1 2.1e-09 36.1 0.9 5.4 3 2 0 3 3 3 2 Hsp70 protein EF-hand_1 PF00036.32 CDI81428.1 - 0.00032 20.0 0.5 0.0012 18.2 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDI81428.1 - 0.00063 20.1 3.7 0.032 14.7 0.4 2.4 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI81428.1 - 0.0027 17.5 0.2 0.0091 15.9 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 CDI81428.1 - 0.006 16.4 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair His_Phos_1 PF00300.22 CDI81429.1 - 8.2e-06 25.6 4.6 0.039 13.6 0.0 2.5 2 1 1 3 3 3 2 Histidine phosphatase superfamily (branch 1) Spt20 PF12090.8 CDI81429.1 - 0.0027 17.3 11.4 0.0031 17.2 11.4 1.1 1 0 0 1 1 1 1 Spt20 family Rubella_E2 PF05749.11 CDI81429.1 - 0.0059 16.1 1.8 0.0068 15.9 1.8 1.2 1 0 0 1 1 1 1 Rubella membrane glycoprotein E2 TFIIA PF03153.13 CDI81429.1 - 0.0068 16.4 8.7 0.0073 16.3 8.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI81429.1 - 0.012 14.6 7.6 0.014 14.4 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) MAP65_ASE1 PF03999.12 CDI81429.1 - 0.018 13.8 0.4 0.018 13.7 0.4 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF908 PF06012.12 CDI81429.1 - 0.058 12.8 4.2 0.069 12.6 4.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) BAT2_N PF07001.11 CDI81429.1 - 0.06 13.8 10.5 0.074 13.5 10.5 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Ndc1_Nup PF09531.10 CDI81429.1 - 0.11 11.2 3.3 0.11 11.1 3.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PadR PF03551.14 CDI81429.1 - 0.13 12.2 0.5 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family MGC-24 PF05283.11 CDI81429.1 - 0.13 12.7 4.7 0.17 12.3 4.7 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF4366 PF14283.6 CDI81429.1 - 0.17 11.9 1.6 0.22 11.6 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Herpes_DNAp_acc PF04929.12 CDI81429.1 - 0.29 10.1 2.6 0.31 10.0 2.6 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Roughex PF06020.11 CDI81429.1 - 0.5 9.4 3.8 0.56 9.3 3.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein CDK2AP PF09806.9 CDI81429.1 - 0.51 10.4 10.7 0.58 10.2 10.7 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein PEHE PF15275.6 CDI81429.1 - 0.64 10.7 5.0 0.44 11.2 3.6 1.5 1 1 0 1 1 1 0 PEHE domain Sporozoite_P67 PF05642.11 CDI81429.1 - 1.7 6.6 7.6 2.1 6.4 7.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tic110 PF16940.5 CDI81429.1 - 4.3 5.7 7.1 4.8 5.5 7.1 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF1180 PF06679.12 CDI81429.1 - 4.5 7.7 8.3 6 7.2 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SIP1 PF04938.12 CDI81430.1 - 9.7e-07 28.7 17.7 9.7e-07 28.7 17.7 4.0 3 2 1 4 4 4 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) RAP1 PF07218.11 CDI81430.1 - 0.025 12.9 6.5 0.035 12.4 6.5 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Yos1 PF08571.10 CDI81430.1 - 0.25 11.6 0.0 0.25 11.6 0.0 2.8 3 1 0 3 3 3 0 Yos1-like LAP1C PF05609.12 CDI81430.1 - 1.5 7.8 32.8 0.11 11.6 13.7 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) GET2 PF08690.10 CDI81430.1 - 1.7 8.2 32.1 0.21 11.2 6.4 2.8 2 1 1 3 3 3 0 GET complex subunit GET2 SR-25 PF10500.9 CDI81430.1 - 6.7 6.3 42.6 0.88 9.1 5.7 2.9 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Clat_adaptor_s PF01217.20 CDI81431.1 - 1.6e-43 148.1 3.2 1.7e-43 148.0 3.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Gln-synt_N PF03951.19 CDI81432.1 - 4.7e-22 77.5 0.0 1e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_C PF00120.24 CDI81432.1 - 5.9e-08 32.1 0.0 1e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain DUF1053 PF06327.14 CDI81432.1 - 0.05 14.2 1.3 0.079 13.5 1.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Methyltransf_4 PF02390.17 CDI81432.1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase SNN_cytoplasm PF09051.10 CDI81432.1 - 0.092 12.6 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Stannin cytoplasmic PTS_EIIB PF00367.20 CDI81432.1 - 0.14 11.6 0.2 0.26 10.8 0.2 1.4 1 0 0 1 1 1 0 phosphotransferase system, EIIB SUIM_assoc PF16619.5 CDI81432.1 - 1.6 8.8 12.2 3.6 7.7 12.2 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PP2C PF00481.21 CDI81434.1 - 1.7e-36 126.2 0.0 2.5e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI81434.1 - 0.0061 16.5 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) BLOC1S3 PF15753.5 CDI81434.1 - 0.21 11.7 3.1 2.5 8.2 1.8 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Biotin_lipoyl PF00364.22 CDI81435.1 - 2.1e-32 110.8 0.1 6.2e-15 54.8 0.0 2.3 2 0 0 2 2 2 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDI81435.1 - 2.1e-12 46.7 0.3 0.014 15.2 0.0 3.9 2 1 1 3 3 3 3 Biotin-lipoyl like HlyD_3 PF13437.6 CDI81435.1 - 2.6e-07 31.3 0.4 2.1 9.1 0.0 4.2 4 0 0 4 4 4 3 HlyD family secretion protein HlyD_D23 PF16576.5 CDI81435.1 - 6.6e-06 25.5 0.3 0.51 9.5 0.0 3.5 2 1 1 3 3 3 3 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 CDI81435.1 - 0.0012 18.7 0.7 0.43 10.5 0.0 3.1 1 1 1 3 3 3 1 Glycine cleavage H-protein Peptidase_M23 PF01551.22 CDI81435.1 - 0.037 14.2 3.9 2.1 8.6 0.1 3.8 2 2 2 4 4 4 0 Peptidase family M23 Shadoo PF14999.6 CDI81437.1 - 0.0031 17.6 2.4 0.0031 17.6 2.4 4.3 3 1 1 4 4 4 1 Shadow of prion protein, neuroprotective SPX PF03105.19 CDI81437.1 - 0.082 12.8 29.6 0.12 12.3 29.6 1.2 1 0 0 1 1 1 0 SPX domain Bud13 PF09736.9 CDI81437.1 - 0.31 11.4 7.4 0.45 10.9 7.4 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF572 PF04502.13 CDI81437.1 - 0.37 10.4 15.3 0.54 9.8 15.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S64 PF08192.11 CDI81437.1 - 0.68 8.3 24.1 0.86 8.0 24.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 PNISR PF15996.5 CDI81437.1 - 4.9 7.4 18.4 1.5 9.1 15.5 1.6 1 1 1 2 2 2 0 Arginine/serine-rich protein PNISR MAT1 PF06391.13 CDI81437.1 - 9.1 6.0 14.5 2 8.2 11.4 1.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 SLC12 PF03522.15 CDI81437.1 - 9.6 5.1 13.3 12 4.8 13.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Pkinase PF00069.25 CDI81439.1 - 2.8e-08 33.5 3.3 6.1e-05 22.5 1.1 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI81439.1 - 1.6e-05 24.3 0.1 0.00027 20.3 0.0 2.3 1 1 0 2 2 2 1 Protein tyrosine kinase SUIM_assoc PF16619.5 CDI81439.1 - 0.011 15.8 22.6 0.05 13.7 0.3 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TMEM208_SND2 PF05620.11 CDI81439.1 - 0.043 13.6 0.7 0.043 13.6 0.7 2.2 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Ribosomal_60s PF00428.19 CDI81439.1 - 0.091 13.4 21.8 0.093 13.3 1.0 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein Exonuc_VII_L PF02601.15 CDI81439.1 - 0.21 11.1 6.9 0.29 10.7 6.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit O-antigen_lig PF13425.6 CDI81439.1 - 0.32 9.8 1.0 0.41 9.4 1.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 CDI81439.1 - 1.3 7.7 6.6 1.9 7.2 6.6 1.1 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDI81439.1 - 1.5 7.8 3.9 2.1 7.3 3.9 1.2 1 0 0 1 1 1 0 CLN3 protein tRNA_lig_CPD PF08302.11 CDI81439.1 - 3.5 7.0 12.2 70 2.7 12.9 2.0 1 1 1 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain DUF3273 PF11677.8 CDI81440.1 - 8.1e-05 22.1 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) RskA PF10099.9 CDI81440.1 - 0.03 14.6 10.4 0.036 14.4 10.4 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Med3 PF11593.8 CDI81440.1 - 0.66 9.1 17.4 0.8 8.8 17.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal UFD1 PF03152.14 CDI81442.1 - 1.9e-40 138.2 0.0 2.1e-40 138.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Tmemb_9 PF05434.11 CDI81445.1 - 0.071 13.0 0.5 0.17 11.7 0.5 1.6 1 0 0 1 1 1 0 TMEM9 EphA2_TM PF14575.6 CDI81445.1 - 0.21 12.5 4.6 1.3 9.9 0.6 3.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 CDI81445.1 - 0.36 11.8 3.7 0.2 12.6 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) BatA PF07584.11 CDI81445.1 - 1.5 9.2 7.1 0.79 10.1 3.6 2.3 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal TAT_signal PF10518.9 CDI81445.1 - 2.6 8.0 10.9 0.76 9.7 2.2 3.4 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence Atrophin-1 PF03154.15 CDI81445.1 - 2.7 6.2 3.6 4.2 5.5 3.6 1.2 1 0 0 1 1 1 0 Atrophin-1 family Ion_trans PF00520.31 CDI81445.1 - 7.6 5.7 9.6 11 5.1 9.6 1.2 1 0 0 1 1 1 0 Ion transport protein DASH_Dam1 PF08653.10 CDI81446.1 - 0.043 13.6 0.9 0.078 12.8 0.2 1.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 COG5 PF10392.9 CDI81446.1 - 0.067 13.4 0.9 0.16 12.2 0.2 1.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 KxDL PF10241.9 CDI81446.1 - 0.2 12.0 4.2 6.6 7.1 0.9 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein T3SS_needle_E PF08988.10 CDI81446.1 - 0.53 10.5 0.2 0.53 10.5 0.2 2.3 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle DUF2570 PF10828.8 CDI81446.1 - 2.3 8.1 7.2 10 6.0 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) DUF4510 PF14971.6 CDI81446.1 - 4.2 7.7 8.4 2 8.7 2.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4510) E1_dh PF00676.20 CDI81447.1 - 6.5e-71 238.7 0.2 5e-70 235.8 0.2 1.9 1 1 0 1 1 1 1 Dehydrogenase E1 component SR-25 PF10500.9 CDI81448.1 - 8 6.0 16.9 12 5.4 14.4 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI81449.1 - 0.0022 17.6 8.3 0.0026 17.4 8.3 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Ribosomal_60s PF00428.19 CDI81449.1 - 0.0038 17.8 23.9 0.15 12.7 8.7 2.3 2 0 0 2 2 2 2 60s Acidic ribosomal protein MatE PF01554.18 CDI81455.1 - 0.0017 18.1 7.6 0.25 11.0 0.2 2.3 2 0 0 2 2 2 2 MatE INSIG PF07281.12 CDI81455.1 - 0.043 13.5 0.4 0.48 10.0 0.1 2.2 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) Gastrin PF00918.17 CDI81455.1 - 0.067 14.2 2.4 1.5 9.8 0.7 2.1 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Spt20 PF12090.8 CDI81455.1 - 0.19 11.3 14.2 0.21 11.1 4.8 2.1 2 0 0 2 2 2 0 Spt20 family DUF2370 PF10176.9 CDI81455.1 - 0.21 11.2 0.8 0.91 9.1 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) DUF5542 PF17696.1 CDI81455.1 - 2.4 8.4 0.0 2.4 8.4 0.0 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5542) R_equi_Vir PF05526.11 CDI81455.1 - 2.5 7.9 4.3 4.8 7.0 2.3 2.0 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein SUIM_assoc PF16619.5 CDI81456.1 - 0.059 13.4 0.0 0.059 13.4 0.0 22.8 4 2 8 12 12 12 0 Unstructured region C-term to UIM in Ataxin3 PIG-U PF06728.13 CDI81456.1 - 0.13 11.3 1.1 3.6 6.5 0.1 2.9 2 0 0 2 2 2 0 GPI transamidase subunit PIG-U EOS1 PF12326.8 CDI81458.1 - 3.2 7.7 6.0 2.1 8.3 0.3 2.6 2 0 0 2 2 2 0 N-glycosylation protein DctQ PF04290.12 CDI81461.1 - 0.025 14.5 0.2 0.049 13.6 0.2 1.4 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF4386 PF14329.6 CDI81461.1 - 0.62 9.9 5.9 1.7 8.4 5.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) N6_N4_Mtase PF01555.18 CDI81462.1 - 4.6e-07 29.8 3.7 0.00034 20.4 0.1 3.7 3 1 1 4 4 4 2 DNA methylase UPF0020 PF01170.18 CDI81462.1 - 4.6e-07 29.7 0.1 6.1e-06 26.1 0.1 2.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 CDI81462.1 - 0.033 13.5 0.4 2.6 7.2 0.0 2.6 3 0 0 3 3 3 0 N-6 DNA Methylase DnaA_N PF11638.8 CDI81462.1 - 0.058 13.2 1.0 1.9 8.3 0.4 2.4 2 0 0 2 2 2 0 DnaA N-terminal domain MT-A70 PF05063.14 CDI81462.1 - 0.12 12.3 0.0 0.5 10.3 0.0 2.0 2 0 0 2 2 2 0 MT-A70 DUF483 PF04467.12 CDI81463.1 - 0.25 11.4 0.0 0.4 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF483) EPL1 PF10513.9 CDI81464.1 - 3.4 8.0 11.5 1.3 9.4 0.5 3.7 3 1 0 3 3 3 0 Enhancer of polycomb-like CD20 PF04103.15 CDI81464.1 - 6.4 6.9 6.4 5.3 7.1 2.2 2.4 2 0 0 2 2 2 0 CD20-like family CwfJ_C_2 PF04676.14 CDI81469.1 - 0.14 13.0 3.7 0.17 12.8 0.2 2.5 3 0 0 3 3 3 0 Protein similar to CwfJ C-terminus 2 DUF1754 PF08555.10 CDI81469.1 - 1.5 9.6 16.8 0.83 10.5 7.1 2.3 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) ASFV_J13L PF05568.11 CDI81469.1 - 3 7.6 8.2 1.6 8.5 5.7 1.8 2 1 1 3 3 3 0 African swine fever virus J13L protein Choline_transpo PF04515.12 CDI81471.1 - 0.054 12.7 7.5 0.036 13.3 1.3 2.7 3 0 0 3 3 3 0 Plasma-membrane choline transporter CAP PF00188.26 CDI81473.1 - 1.1e-11 45.7 0.1 2.2e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TSP_1 PF00090.19 CDI81473.1 - 0.00071 19.7 6.9 0.0026 17.9 6.9 2.1 1 0 0 1 1 1 1 Thrombospondin type 1 domain AP4E_app_platf PF14807.6 CDI81475.1 - 3.4e-10 40.2 0.0 8.2e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform MOZART1 PF12554.8 CDI81476.1 - 0.054 13.3 0.3 0.27 11.1 0.1 1.9 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated STG PF15809.5 CDI81476.1 - 0.065 13.3 0.1 0.094 12.8 0.1 1.3 1 1 0 1 1 1 0 Simian taste bud-specific gene product family MIP PF00230.20 CDI81478.1 - 1.8e-13 50.7 34.0 4.9e-09 36.2 16.4 3.7 1 1 3 4 4 4 4 Major intrinsic protein PTPA PF03095.15 CDI81480.1 - 7.1e-70 235.8 0.0 9e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein SLX9 PF15341.6 CDI81481.1 - 0.018 15.4 12.3 0.14 12.5 0.7 2.1 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 U1snRNP70_N PF12220.8 CDI81481.1 - 1.8 9.3 16.3 0.9 10.2 1.5 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF765 PF05570.11 CDI81481.1 - 3.7 7.8 6.3 6.4 7.0 0.4 3.0 3 0 0 3 3 3 0 Circovirus protein of unknown function (DUF765) Ferlin_C PF16165.5 CDI81481.1 - 6 6.8 6.9 1.2 9.1 0.3 2.0 1 1 1 2 2 2 0 Ferlin C-terminus TPR_1 PF00515.28 CDI81482.1 - 1.2e-09 37.6 0.5 4.3e-05 23.1 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI81482.1 - 1.2e-08 34.4 1.0 0.0018 18.3 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Spt20 PF12090.8 CDI81482.1 - 0.0074 15.9 7.7 0.0095 15.6 7.7 1.3 1 0 0 1 1 1 1 Spt20 family TPR_17 PF13431.6 CDI81482.1 - 0.025 14.9 0.1 0.025 14.9 0.1 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDI81482.1 - 0.03 14.2 1.0 1.6 8.7 0.5 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat MMR1 PF08505.10 CDI81482.1 - 0.047 14.0 4.9 0.062 13.6 4.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.13 CDI81482.1 - 0.048 13.7 14.2 0.054 13.5 14.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM117 PF15388.6 CDI81482.1 - 0.078 12.4 7.8 0.095 12.1 7.8 1.1 1 0 0 1 1 1 0 Protein Family FAM117 Baculo_p24 PF05073.12 CDI81482.1 - 0.092 12.5 2.4 0.12 12.1 2.4 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein DUF4255 PF14065.6 CDI81482.1 - 0.19 11.4 3.9 0.34 10.6 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4255) TPR_12 PF13424.6 CDI81482.1 - 0.21 11.9 7.1 0.43 10.9 2.9 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat Activator_LAG-3 PF11498.8 CDI81482.1 - 0.28 10.1 26.4 0.4 9.6 26.4 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Presenilin PF01080.17 CDI81482.1 - 0.33 9.7 5.3 0.44 9.3 5.3 1.1 1 0 0 1 1 1 0 Presenilin AAA_23 PF13476.6 CDI81482.1 - 0.9 10.0 13.7 0.14 12.7 8.2 1.9 2 0 0 2 2 2 0 AAA domain Allexi_40kDa PF05549.11 CDI81482.1 - 0.91 9.0 5.8 0.41 10.1 2.7 1.7 1 1 0 2 2 2 0 Allexivirus 40kDa protein ALMT PF11744.8 CDI81482.1 - 1.1 8.0 3.6 1.3 7.8 3.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1840 PF08895.11 CDI81482.1 - 1.3 9.4 11.4 6.3 7.2 5.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Neur_chan_memb PF02932.16 CDI81482.1 - 3.1 7.8 4.8 3.7 7.5 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FlxA PF14282.6 CDI81482.1 - 5.5 7.0 32.2 0.48 10.4 1.3 2.4 2 0 0 2 2 2 0 FlxA-like protein DUF2992 PF11208.8 CDI81482.1 - 9.2 6.5 19.8 0.52 10.6 10.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) DFP PF04127.15 CDI81483.1 - 2.2e-14 53.7 0.0 2.7e-07 30.6 0.0 3.3 3 0 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein EF-hand_6 PF13405.6 CDI81484.1 - 0.011 15.6 1.7 0.045 13.7 1.7 2.1 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 CDI81484.1 - 0.018 15.5 0.1 0.046 14.2 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair DUF3106 PF11304.8 CDI81484.1 - 0.046 14.2 0.1 0.14 12.7 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) EF-hand_1 PF00036.32 CDI81484.1 - 1.8 8.3 3.8 2.8 7.7 2.7 2.0 2 0 0 2 2 2 0 EF hand CDC50 PF03381.15 CDI81485.1 - 1e-50 172.8 0.0 1.5e-50 172.3 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF1282 PF06930.12 CDI81487.1 - 0.011 15.6 0.1 0.011 15.6 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) DUF4396 PF14342.6 CDI81487.1 - 0.1 12.9 10.1 0.11 12.8 0.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4396) Prenyltrans PF00432.21 CDI81488.1 - 4.1e-39 132.0 19.3 2.3e-08 33.7 0.6 6.4 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CDI81488.1 - 7.5e-07 28.5 0.0 0.039 13.1 0.0 3.4 1 1 2 3 3 3 3 Squalene-hopene cyclase N-terminal domain SprA-related PF12118.8 CDI81489.1 - 0.0047 16.1 7.8 0.0062 15.7 7.8 1.1 1 0 0 1 1 1 1 SprA-related family RRM_1 PF00076.22 CDI81490.1 - 3.8e-07 29.8 0.0 6.9e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDI81490.1 - 0.0019 17.8 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ABC_tran PF00005.27 CDI81492.1 - 1.1e-17 64.8 0.0 1.1e-17 64.8 0.0 2.3 2 1 0 2 2 1 1 ABC transporter TFIIA PF03153.13 CDI81492.1 - 7.2e-06 26.3 12.9 8.1e-06 26.1 12.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI81492.1 - 8.3e-05 21.4 15.8 0.0001 21.1 15.8 1.2 1 0 0 1 1 1 1 Macoilin family SMC_N PF02463.19 CDI81492.1 - 0.00083 18.9 0.6 0.027 13.9 0.0 3.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain Hamartin PF04388.12 CDI81492.1 - 0.0017 17.2 13.0 0.0021 16.9 13.0 1.1 1 0 0 1 1 1 1 Hamartin protein AAA_21 PF13304.6 CDI81492.1 - 0.0033 17.3 7.7 0.17 11.6 0.3 2.9 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDI81492.1 - 0.0052 16.5 0.1 0.0052 16.5 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI81492.1 - 0.008 16.1 0.1 0.018 14.9 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase SPX PF03105.19 CDI81492.1 - 0.038 13.9 27.3 0.054 13.4 27.3 1.2 1 0 0 1 1 1 0 SPX domain NB-ARC PF00931.22 CDI81492.1 - 0.054 12.7 0.0 2.9 7.0 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain SOG2 PF10428.9 CDI81492.1 - 0.1 11.7 23.6 0.15 11.2 23.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Ndc1_Nup PF09531.10 CDI81492.1 - 0.24 10.1 12.0 0.33 9.6 12.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PNISR PF15996.5 CDI81492.1 - 0.41 10.9 15.2 0.78 10.0 15.2 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 CDI81492.1 - 0.71 8.6 16.0 1.1 8.0 16.0 1.3 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 CDI81492.1 - 1.1 6.3 17.1 1.2 6.1 17.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 CDI81492.1 - 1.2 7.9 21.7 1.8 7.3 21.7 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain SARAF PF06682.12 CDI81492.1 - 1.3 8.6 11.3 2.5 7.7 11.3 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Raftlin PF15250.6 CDI81492.1 - 1.4 7.6 11.5 1.8 7.3 11.5 1.2 1 0 0 1 1 1 0 Raftlin Membralin PF09746.9 CDI81492.1 - 1.9 7.4 5.7 3.2 6.7 5.7 1.4 1 0 0 1 1 1 0 Tumour-associated protein Menin PF05053.13 CDI81492.1 - 2.8 6.2 15.5 4.5 5.5 15.5 1.3 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 CDI81492.1 - 5 6.0 14.9 7.9 5.4 14.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Utp14 PF04615.13 CDI81492.1 - 9 4.7 24.9 13 4.2 24.9 1.1 1 0 0 1 1 1 0 Utp14 protein RAP1 PF07218.11 CDI81492.1 - 9.2 4.4 13.9 13 3.9 13.9 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SPATIAL PF15256.6 CDI81492.1 - 9.6 6.5 14.3 13 6.0 13.5 1.5 1 1 0 1 1 1 0 SPATIAL BTB PF00651.31 CDI81495.1 - 1.2e-15 57.7 0.0 8.2e-15 55.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain PP2C PF00481.21 CDI81496.1 - 7.9e-42 143.7 0.0 1.4e-41 142.8 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C DUF3398 PF11878.8 CDI81496.1 - 0.01 16.2 1.7 0.15 12.5 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3398) PRKG1_interact PF15898.5 CDI81496.1 - 0.026 15.4 2.4 0.047 14.6 2.4 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF4132 PF13569.6 CDI81496.1 - 0.054 13.3 3.5 0.09 12.6 1.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4132) MRP-S26 PF14943.6 CDI81496.1 - 0.064 13.2 3.3 0.1 12.5 3.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 UPF0225 PF17775.1 CDI81496.1 - 0.07 13.9 0.1 0.28 12.0 0.0 2.0 2 0 0 2 2 2 0 UPF0225 domain SpoIIE PF07228.12 CDI81496.1 - 0.071 13.0 0.0 0.77 9.6 0.0 2.3 2 1 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) TFIIA PF03153.13 CDI81500.1 - 0.48 10.4 13.0 0.57 10.1 13.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Secretin_N_2 PF07655.13 CDI81500.1 - 0.5 10.9 13.3 0.97 10.0 13.3 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain SR-25 PF10500.9 CDI81500.1 - 0.58 9.7 12.8 1.1 8.9 12.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4834 PF16118.5 CDI81500.1 - 3.4 8.7 5.2 1 10.4 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF3273 PF11677.8 CDI81501.1 - 4.4e-94 314.7 6.0 5.2e-94 314.5 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) Tetraspanin PF00335.20 CDI81501.1 - 8.2 6.1 8.4 41 3.8 3.1 2.9 1 1 2 3 3 3 0 Tetraspanin family SCO1-SenC PF02630.14 CDI81503.1 - 3.3e-19 69.1 0.1 7.9e-13 48.5 0.0 2.6 1 1 1 2 2 2 2 SCO1/SenC AhpC-TSA PF00578.21 CDI81503.1 - 0.012 15.5 0.1 0.034 14.0 0.1 1.8 1 0 0 1 1 1 0 AhpC/TSA family SOBP PF15279.6 CDI81503.1 - 0.17 12.4 28.0 0.28 11.7 28.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein eIF-3_zeta PF05091.12 CDI81503.1 - 0.53 9.2 20.5 0.77 8.7 20.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RCR PF12273.8 CDI81503.1 - 0.57 10.9 15.4 0.11 13.1 11.6 1.8 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red CDC45 PF02724.14 CDI81503.1 - 0.76 8.0 17.8 1.3 7.3 17.8 1.3 1 0 0 1 1 1 0 CDC45-like protein SOG2 PF10428.9 CDI81503.1 - 1.1 8.3 30.0 1.5 7.9 30.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SLC12 PF03522.15 CDI81503.1 - 1.2 8.0 17.7 2.1 7.3 17.7 1.5 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI81503.1 - 1.4 7.1 35.7 1.9 6.6 35.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Serinc PF03348.15 CDI81503.1 - 2.2 7.1 8.2 4.8 6.0 8.2 1.6 1 0 0 1 1 1 0 Serine incorporator (Serinc) SpoIIP PF07454.11 CDI81503.1 - 2.4 7.5 17.5 4.4 6.7 17.5 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) ALMT PF11744.8 CDI81503.1 - 3.3 6.4 14.2 5.9 5.6 14.2 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Tim54 PF11711.8 CDI81503.1 - 3.7 6.2 16.3 7.5 5.2 16.3 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 GREB1 PF15782.5 CDI81503.1 - 4.2 4.4 27.6 5.4 4.0 27.6 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF1345 PF07077.11 CDI81503.1 - 5.2 6.7 6.9 3.7 7.2 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) DUF913 PF06025.12 CDI81503.1 - 5.5 5.9 12.6 9.3 5.1 12.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Plasmodium_Vir PF05795.11 CDI81503.1 - 7.1 5.9 17.4 14 5.0 17.4 1.5 1 0 0 1 1 1 0 Plasmodium vivax Vir protein HHH_8 PF14716.6 CDI81506.1 - 0.022 15.1 0.0 0.63 10.4 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix domain APH PF01636.23 CDI81506.1 - 0.31 10.9 4.6 0.19 11.6 1.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family NopRA1 PF16201.5 CDI81507.1 - 1.3e-06 28.2 0.4 1.3e-06 28.2 0.4 2.4 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Npa1 PF11707.8 CDI81507.1 - 0.031 13.6 0.0 0.095 12.0 0.0 1.8 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal Pex16 PF08610.10 CDI81507.1 - 0.17 11.0 7.1 0.06 12.5 0.4 3.0 3 0 0 3 3 3 0 Peroxisomal membrane protein (Pex16) GOLD_2 PF13897.6 CDI81507.1 - 2.8 8.4 5.1 1.1 9.8 0.3 2.6 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking ISP1_C PF18161.1 CDI81508.1 - 4.5e-40 136.0 0.0 5.9e-40 135.6 0.0 1.1 1 0 0 1 1 1 1 ISP1 C-terminal ISP3_C PF18045.1 CDI81508.1 - 1.6e-38 131.0 0.0 2e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 ISP3 C-terminal CENP-C_C PF11699.8 CDI81509.1 - 0.0064 16.7 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like WD40 PF00400.32 CDI81510.1 - 5.8e-15 55.4 14.4 0.00054 20.7 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat MutL PF13941.6 CDI81510.1 - 0.28 9.7 1.3 0.46 9.0 1.3 1.2 1 0 0 1 1 1 0 MutL protein SPX PF03105.19 CDI81511.1 - 0.0086 16.0 22.8 0.0086 16.0 22.8 4.7 3 1 1 4 4 4 1 SPX domain RabGAP-TBC PF00566.18 CDI81512.1 - 0.00098 18.8 0.6 0.0019 17.9 0.0 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Activator_LAG-3 PF11498.8 CDI81512.1 - 1.4 7.8 20.9 3.8 6.4 20.9 1.7 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MecA PF05389.12 CDI81514.1 - 0.00027 20.6 9.6 0.0039 16.9 6.9 2.2 2 0 0 2 2 2 1 Negative regulator of genetic competence (MecA) Suf PF05843.14 CDI81514.1 - 0.00037 20.6 20.2 0.00037 20.6 20.2 2.2 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) DDHD PF02862.17 CDI81514.1 - 0.0015 18.8 12.2 0.0019 18.4 6.8 2.2 2 0 0 2 2 2 1 DDHD domain Band_3_cyto PF07565.13 CDI81514.1 - 0.0056 16.5 5.2 0.0056 16.5 5.2 2.2 2 0 0 2 2 2 1 Band 3 cytoplasmic domain UPF0061 PF02696.14 CDI81514.1 - 0.036 12.8 11.0 0.064 12.0 11.0 1.3 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family V_ATPase_I PF01496.19 CDI81514.1 - 0.16 9.8 14.6 0.015 13.3 9.3 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Fanconi_A PF03511.14 CDI81514.1 - 0.18 11.7 1.1 28 4.7 0.1 2.7 2 0 0 2 2 2 0 Fanconi anaemia group A protein ALO PF04030.14 CDI81514.1 - 0.25 11.1 7.7 0.5 10.1 7.7 1.4 1 0 0 1 1 1 0 D-arabinono-1,4-lactone oxidase DUF4448 PF14610.6 CDI81514.1 - 0.41 10.4 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF572 PF04502.13 CDI81514.1 - 0.57 9.7 15.9 0.24 11.0 10.9 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) eIF-3_zeta PF05091.12 CDI81514.1 - 0.7 8.8 23.7 0.18 10.8 17.8 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MAT1 PF06391.13 CDI81514.1 - 0.74 9.6 31.9 1.9 8.2 23.8 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF4746 PF15928.5 CDI81514.1 - 0.95 8.8 11.4 0.26 10.7 7.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) FAM60A PF15396.6 CDI81514.1 - 1.1 9.2 13.5 0.3 11.0 8.8 2.0 2 0 0 2 2 2 0 Protein Family FAM60A Connexin PF00029.19 CDI81514.1 - 1.2 8.9 10.7 1.6 8.5 8.3 2.1 2 0 0 2 2 2 0 Connexin DUF4471 PF14740.6 CDI81514.1 - 1.3 8.2 12.3 0.13 11.5 7.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) DUF4484 PF14831.6 CDI81514.1 - 1.4 8.9 15.9 0.42 10.6 11.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) DUF4810 PF16068.5 CDI81514.1 - 1.6 9.3 0.0 1.6 9.3 0.0 4.4 5 1 0 5 5 2 0 Domain of unknown function (DUF4810) Presenilin PF01080.17 CDI81514.1 - 1.6 7.4 22.4 0.41 9.4 17.1 2.1 2 0 0 2 2 2 0 Presenilin PPL5 PF18168.1 CDI81514.1 - 1.7 7.8 17.0 0.11 11.7 10.0 2.2 2 1 0 2 2 2 0 Prim-pol family 5 RR_TM4-6 PF06459.12 CDI81514.1 - 2.3 8.0 17.8 0.98 9.2 13.5 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI81514.1 - 2.6 8.1 20.6 11 6.1 16.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Peptidase_S49_N PF08496.10 CDI81514.1 - 2.8 8.0 21.9 11 6.1 15.6 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 CDI81514.1 - 3.5 5.9 5.6 1.1 7.6 2.6 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DAG_kinase_N PF14513.6 CDI81514.1 - 4.2 7.6 19.9 3.4 7.8 15.0 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Neur_chan_memb PF02932.16 CDI81514.1 - 4.4 7.3 17.3 1.3 9.0 11.6 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EIF4E-T PF10477.9 CDI81514.1 - 4.9 5.9 32.1 1.3 7.8 2.2 2.1 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Plasmodium_Vir PF05795.11 CDI81514.1 - 4.9 6.5 5.2 1.2 8.4 2.1 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Adaptin_binding PF10199.9 CDI81514.1 - 5.4 7.7 23.3 53 4.5 20.9 2.6 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Glyco_transf_41 PF13844.6 CDI81514.1 - 6.4 5.1 12.1 0.76 8.1 7.2 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 41 PPP4R2 PF09184.11 CDI81514.1 - 8.4 5.9 14.3 0.4 10.2 8.2 1.7 2 0 0 2 2 2 0 PPP4R2 Peptidase_S64 PF08192.11 CDI81514.1 - 9.2 4.6 15.4 1.1 7.7 10.3 1.9 3 0 0 3 3 3 0 Peptidase family S64 Topoisom_I PF01028.20 CDI81516.1 - 7.4e-104 346.0 13.4 7.4e-104 346.0 13.4 2.0 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 CDI81516.1 - 6.5e-22 77.2 0.6 6.5e-22 77.2 0.6 2.3 3 0 0 3 3 3 1 C-terminal topoisomerase domain Topoisom_I_N PF02919.15 CDI81516.1 - 6.1e-17 61.8 0.0 6.1e-17 61.8 0.0 4.5 3 2 2 5 5 5 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Acyltransf_C PF16076.5 CDI81516.1 - 0.11 12.6 0.9 0.31 11.2 0.9 1.8 1 0 0 1 1 1 0 Acyltransferase C-terminus DUF3138 PF11336.8 CDI81516.1 - 0.77 8.3 11.6 0.94 8.0 10.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) DUF2868 PF11067.8 CDI81516.1 - 0.77 9.2 8.2 1.3 8.4 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) XPG_I PF00867.18 CDI81516.1 - 1 9.8 6.1 0.25 11.7 1.4 2.4 2 1 0 2 2 2 0 XPG I-region Hist_deacetyl PF00850.19 CDI81517.1 - 1.1e-75 255.0 0.1 1.3e-75 254.7 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain SR-25 PF10500.9 CDI81517.1 - 0.044 13.4 8.7 0.065 12.8 8.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDI81517.1 - 0.086 13.2 8.5 0.16 12.3 8.5 1.3 1 0 0 1 1 1 0 Early growth response N-terminal domain IMUP PF15761.5 CDI81517.1 - 0.096 13.4 6.3 0.16 12.6 6.3 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Hid1 PF12722.7 CDI81519.1 - 3.1e-07 29.0 0.1 3.1e-07 29.0 0.1 3.8 1 1 2 3 3 2 1 High-temperature-induced dauer-formation protein Dicty_REP PF05086.12 CDI81519.1 - 0.04 11.9 23.4 0.051 11.6 23.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LAP1C PF05609.12 CDI81519.1 - 0.26 10.3 40.0 0.32 10.0 40.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dapper PF15268.6 CDI81519.1 - 0.27 10.1 41.7 0.35 9.7 41.7 1.1 1 0 0 1 1 1 0 Dapper DUF572 PF04502.13 CDI81519.1 - 0.39 10.3 33.9 0.51 9.9 33.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) GAGA_bind PF06217.12 CDI81519.1 - 0.56 10.5 26.4 0.82 9.9 26.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Caldesmon PF02029.15 CDI81519.1 - 0.63 8.7 47.6 0.8 8.4 47.6 1.1 1 0 0 1 1 1 0 Caldesmon DUF966 PF06136.13 CDI81519.1 - 0.8 9.4 35.2 1.1 8.9 35.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Ndc1_Nup PF09531.10 CDI81519.1 - 1.1 7.8 33.6 0.06 12.0 27.1 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SRP-alpha_N PF04086.13 CDI81519.1 - 2.6 7.9 39.1 4 7.3 39.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 CDI81519.1 - 3 6.0 44.3 4.2 5.5 44.3 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI81519.1 - 4.2 6.3 46.4 5.6 5.9 46.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4045 PF13254.6 CDI81519.1 - 4.2 6.9 39.4 6.1 6.4 39.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ketoacyl-synt PF00109.26 CDI81520.1 - 1.5e-74 250.8 0.0 3.8e-74 249.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CDI81520.1 - 1.9e-57 194.1 0.0 4.5e-57 192.9 0.0 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CDI81520.1 - 1.9e-44 152.1 0.2 2.9e-44 151.5 0.2 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CDI81520.1 - 1.2e-43 149.8 0.2 2.2e-43 149.0 0.2 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CDI81520.1 - 1.4e-40 137.9 0.1 3.1e-40 136.9 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDI81520.1 - 8.5e-13 48.5 0.0 2e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CDI81520.1 - 2.4e-10 40.2 0.1 1.9e-09 37.2 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 CDI81520.1 - 5.3e-10 39.4 0.0 2.6e-09 37.1 0.0 2.4 2 0 0 2 2 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CDI81520.1 - 5.5e-09 35.9 0.0 1.4e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KAsynt_C_assoc PF16197.5 CDI81520.1 - 3.2e-08 34.0 0.0 7.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_N PF08240.12 CDI81520.1 - 5.8e-06 26.2 1.3 5.2e-05 23.1 1.3 2.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDI81520.1 - 0.00055 21.0 0.0 0.017 16.2 0.0 3.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Thiolase_N PF00108.23 CDI81520.1 - 0.00061 19.2 0.0 0.0016 17.9 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Epimerase PF01370.21 CDI81520.1 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDI81520.1 - 0.0048 16.3 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF1015 PF06245.11 CDI81520.1 - 0.067 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) ACP_syn_III PF08545.10 CDI81520.1 - 0.16 11.9 0.5 0.48 10.3 0.5 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Polysacc_synt_2 PF02719.15 CDI81520.1 - 0.18 10.9 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ApbA PF02558.16 CDI81520.1 - 1.9 8.1 4.9 1.1 8.9 0.2 2.7 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA Glyco_hydro_17 PF00332.18 CDI81522.1 - 8.2e-12 45.3 0.1 1.6e-06 27.9 0.0 3.0 3 0 0 3 3 3 2 Glycosyl hydrolases family 17 RskA PF10099.9 CDI81522.1 - 0.0008 19.8 7.9 0.0008 19.8 7.9 6.5 3 2 1 4 4 4 1 Anti-sigma-K factor rskA CPW_WPC PF09717.10 CDI81523.1 - 3e-50 169.0 22.2 2.6e-16 60.4 6.1 4.6 4 1 0 4 4 4 4 Plasmodium falciparum domain of unknown function (CPW_WPC) Tme5_EGF_like PF09064.10 CDI81523.1 - 0.027 14.4 10.1 0.15 12.0 0.8 3.9 3 1 0 3 3 3 0 Thrombomodulin like fifth domain, EGF-like SUIM_assoc PF16619.5 CDI81524.1 - 0.094 12.8 11.0 0.12 12.4 11.0 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PRIMA1 PF16101.5 CDI81524.1 - 0.13 12.4 3.8 0.13 12.3 3.8 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Spt20 PF12090.8 CDI81524.1 - 0.17 11.4 8.3 0.16 11.6 8.3 1.0 1 0 0 1 1 1 0 Spt20 family Cpn60_TCP1 PF00118.24 CDI81531.1 - 2.4e-81 273.8 0.2 2.7e-81 273.7 0.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Piezo_RRas_bdg PF12166.8 CDI81531.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain Spt20 PF12090.8 CDI81533.1 - 0.013 15.1 1.8 0.013 15.1 1.8 1.8 2 0 0 2 2 2 0 Spt20 family PPP4R2 PF09184.11 CDI81533.1 - 0.053 13.1 4.3 0.057 13.0 4.3 1.1 1 0 0 1 1 1 0 PPP4R2 TMEM51 PF15345.6 CDI81533.1 - 0.12 12.2 1.1 0.17 11.7 0.1 1.8 1 1 1 2 2 2 0 Transmembrane protein 51 PBP1_TM PF14812.6 CDI81533.1 - 0.19 12.1 6.1 5.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3138 PF11336.8 CDI81533.1 - 7.1 5.1 7.9 9.3 4.7 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) MIP-T3_C PF17749.1 CDI81534.1 - 6.9e-05 22.9 1.2 0.00058 19.9 1.2 1.9 1 1 0 1 1 1 1 Microtubule-binding protein MIP-T3 C-terminal region TBCA PF02970.16 CDI81534.1 - 0.013 15.8 0.0 2.2 8.7 0.1 2.1 2 0 0 2 2 2 0 Tubulin binding cofactor A CK2S PF15011.6 CDI81534.1 - 0.078 12.9 0.3 0.15 11.9 0.3 1.5 1 1 0 1 1 1 0 Casein Kinase 2 substrate LXG PF04740.12 CDI81534.1 - 0.11 12.2 1.4 0.12 12.1 0.6 1.4 2 0 0 2 2 2 0 LXG domain of WXG superfamily DUF1826 PF08856.11 CDI81534.1 - 0.12 12.3 0.4 2.3 8.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1826) F-box PF00646.33 CDI81536.1 - 0.018 14.9 0.2 0.056 13.3 0.2 1.9 1 0 0 1 1 1 0 F-box domain DUF5401 PF17380.2 CDI81539.1 - 0.14 10.2 0.0 0.14 10.2 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5401) SprA-related PF12118.8 CDI81539.1 - 1.2 8.2 19.8 1.7 7.7 19.8 1.4 1 0 0 1 1 1 0 SprA-related family AAA_11 PF13086.6 CDI81539.1 - 3.9 7.2 19.8 6.5 6.5 19.8 1.3 1 0 0 1 1 1 0 AAA domain TSP_1 PF00090.19 CDI81540.1 - 2.2e-07 31.0 17.8 0.0022 18.2 4.2 3.0 2 0 0 2 2 2 2 Thrombospondin type 1 domain SUIM_assoc PF16619.5 CDI81542.1 - 0.28 11.3 11.2 0.63 10.1 11.2 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Roughex PF06020.11 CDI81542.1 - 0.77 8.8 2.9 1.3 8.0 2.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 CDI81542.1 - 1.5 8.4 8.1 2.3 7.8 8.1 1.2 1 0 0 1 1 1 0 Spt20 family DAN PF03045.15 CDI81544.1 - 2.6 8.1 8.0 0.27 11.3 2.0 2.6 2 0 0 2 2 2 0 DAN domain Cor1 PF04803.12 CDI81547.1 - 0.026 14.7 4.2 0.026 14.7 4.2 2.3 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Fib_alpha PF08702.10 CDI81547.1 - 2.9 8.1 8.6 0.59 10.3 1.4 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family tRNA-synt_1c PF00749.21 CDI81549.1 - 6.6e-63 212.5 0.3 5.8e-32 110.8 0.0 4.1 4 0 0 4 4 4 3 tRNA synthetases class I (E and Q), catalytic domain DUF4667 PF15700.5 CDI81549.1 - 0.00051 20.2 16.2 0.0052 16.9 0.3 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4667) CobT PF06213.12 CDI81549.1 - 0.037 13.4 11.0 0.028 13.8 3.2 3.0 3 0 0 3 3 3 0 Cobalamin biosynthesis protein CobT TERB2 PF15101.6 CDI81549.1 - 3.7 7.6 8.2 1.9 8.5 3.5 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DAGK_cat PF00781.24 CDI81551.1 - 1.4e-19 69.9 5.5 2.2e-13 49.9 0.0 4.2 3 1 1 4 4 4 2 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.19 CDI81551.1 - 7.5e-15 55.6 0.4 1.1e-10 42.0 0.0 3.2 4 0 0 4 4 4 2 Diacylglycerol kinase accessory domain Sin_N PF04801.13 CDI81551.1 - 0.00013 21.3 9.3 0.00013 21.3 9.3 4.4 2 2 2 4 4 4 1 Sin-like protein conserved region Mem_trans PF03547.18 CDI81551.1 - 0.016 13.6 0.1 0.016 13.6 0.1 3.0 3 1 0 3 3 3 0 Membrane transport protein DUF5345 PF17280.2 CDI81551.1 - 0.075 13.0 0.1 0.075 13.0 0.1 6.7 6 1 1 7 7 7 0 Family of unknown function (DUF5345) MarC PF01914.17 CDI81551.1 - 0.46 9.8 0.0 0.46 9.8 0.0 2.4 3 0 0 3 3 3 0 MarC family integral membrane protein Caldesmon PF02029.15 CDI81551.1 - 6.5 5.4 55.6 0.11 11.2 27.6 2.6 2 1 0 2 2 2 0 Caldesmon Sec7_N PF12783.7 CDI81555.1 - 1.9e-06 27.8 2.7 1.9e-06 27.8 2.7 2.4 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal TFIIA PF03153.13 CDI81555.1 - 0.0046 17.0 7.7 0.0046 17.0 7.7 3.6 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Ribosomal_L6 PF00347.23 CDI81558.1 - 1.2e-24 86.7 0.7 1.7e-14 54.2 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 CENP-W PF15510.6 CDI81558.1 - 0.038 14.2 0.5 2.3 8.5 0.1 2.4 2 0 0 2 2 2 0 CENP-W protein DUF2400 PF09674.10 CDI81559.1 - 0.054 13.5 0.1 0.081 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) CENP-H PF05837.12 CDI81559.1 - 0.27 11.7 5.3 0.44 11.0 5.3 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4106 PF13388.6 CDI81560.1 - 0.0056 16.0 2.9 0.0085 15.4 2.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4106) DUF4207 PF13904.6 CDI81560.1 - 0.023 14.4 8.0 0.035 13.8 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) RWD PF05773.22 CDI81560.1 - 0.11 12.7 3.2 0.21 11.9 3.2 1.4 1 0 0 1 1 1 0 RWD domain GREB1 PF15782.5 CDI81560.1 - 0.55 7.3 5.5 0.7 6.9 5.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TCP PF03634.13 CDI81560.1 - 0.55 10.8 6.5 0.38 11.3 3.9 2.0 2 0 0 2 2 2 0 TCP family transcription factor DUF5345 PF17280.2 CDI81560.1 - 1 9.4 5.8 3.5 7.7 5.8 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Spt20 PF12090.8 CDI81560.1 - 1.4 8.5 12.8 2.2 7.8 12.8 1.3 1 0 0 1 1 1 0 Spt20 family NAM-associated PF14303.6 CDI81560.1 - 2.8 8.6 11.5 0.13 13.0 5.8 1.6 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain DUF1645 PF07816.11 CDI81560.1 - 7 7.2 13.8 3.7 8.1 2.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1645) Syntaphilin PF15290.6 CDI81560.1 - 8.1 6.0 11.1 13 5.3 11.1 1.2 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp Peptidase_S8 PF00082.22 CDI81563.1 - 1.3e-24 87.0 12.0 9.7e-20 71.0 2.8 4.6 2 2 2 4 4 4 2 Subtilase family Apt1 PF10351.9 CDI81563.1 - 0.0057 15.6 19.5 0.012 14.5 19.5 1.6 1 0 0 1 1 1 1 Golgi-body localisation protein domain SPX PF03105.19 CDI81563.1 - 7.4 6.4 32.0 0.52 10.2 26.6 1.7 2 0 0 2 2 2 0 SPX domain DnaJ_C PF01556.18 CDI81564.1 - 1.5e-39 135.5 0.1 9.7e-29 100.4 0.1 2.1 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.31 CDI81564.1 - 3.2e-24 84.8 3.3 5.5e-24 84.1 3.3 1.4 1 0 0 1 1 1 1 DnaJ domain LprI PF07007.12 CDI81564.1 - 0.27 11.9 5.9 0.49 11.1 0.0 2.4 2 0 0 2 2 2 0 Lysozyme inhibitor LprI DUF389 PF04087.14 CDI81564.1 - 2.6 8.1 14.4 4.3 7.4 14.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF389) Myb_DNA-binding PF00249.31 CDI81566.1 - 0.0032 17.6 0.0 0.006 16.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain EF-hand_7 PF13499.6 CDI81568.1 - 2e-19 69.8 0.1 4.4e-12 46.3 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI81568.1 - 2.1e-18 64.4 0.4 4.8e-06 25.7 0.1 3.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDI81568.1 - 4.3e-17 60.5 1.0 1.2e-06 28.0 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDI81568.1 - 1.3e-11 43.4 0.6 2.3e-05 23.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDI81568.1 - 3.7e-11 42.7 0.6 8.9e-06 25.5 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_11 PF08976.11 CDI81568.1 - 6e-07 30.3 0.0 7.9e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_9 PF14658.6 CDI81568.1 - 0.00059 20.1 0.1 0.025 14.9 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 CDI81568.1 - 0.014 15.8 0.0 0.028 14.7 0.0 1.7 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 CDI81568.1 - 0.015 15.5 0.2 0.35 11.1 0.0 2.7 2 1 1 3 3 3 0 Dockerin type I domain Caleosin PF05042.13 CDI81568.1 - 0.033 14.1 0.0 0.73 9.7 0.0 2.2 1 1 1 2 2 2 0 Caleosin related protein DUF5580 PF17743.1 CDI81568.1 - 0.042 12.4 0.0 0.046 12.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) MHCassoc_trimer PF08831.10 CDI81568.1 - 0.071 13.1 0.5 1.5 8.9 0.3 2.3 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain GPHH PF16905.5 CDI81568.1 - 0.2 11.5 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated PAT1 PF09770.9 CDI81573.1 - 2 6.6 34.3 3.1 6.0 34.3 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI81573.1 - 7.1 3.6 16.7 11 3.0 16.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Fasciclin PF02469.22 CDI81574.1 - 5.6e-07 29.8 0.0 2.4e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 Fasciclin domain DUF4404 PF14357.6 CDI81576.1 - 0.027 15.1 0.3 12 6.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Notch PF00066.17 CDI81577.1 - 3.1e-42 142.7 105.3 8.7e-08 32.5 12.5 6.3 6 0 0 6 6 6 6 LNR domain DUF4949 PF16307.5 CDI81577.1 - 0.034 14.3 0.1 0.056 13.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4949) NKAP PF15692.5 CDI81578.1 - 5.3 7.8 22.2 5.2 7.9 1.6 2.6 2 0 0 2 2 2 0 NF-kappa-B-activating protein AAA_12 PF13087.6 CDI81579.1 - 0.00012 21.8 0.6 0.00012 21.8 0.6 1.7 2 0 0 2 2 2 1 AAA domain Shadoo PF14999.6 CDI81579.1 - 0.041 14.0 5.5 0.074 13.1 5.5 1.3 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective TFIIA PF03153.13 CDI81579.1 - 0.13 12.2 13.7 0.18 11.8 13.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nucleo_P87 PF07267.11 CDI81579.1 - 2.1 7.1 7.0 2.6 6.8 7.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Tim54 PF11711.8 CDI81579.1 - 3.4 6.4 11.0 0.35 9.6 6.0 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DNA_pol_delta_4 PF04081.13 CDI81580.1 - 3.4e-19 69.5 0.0 4.6e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 FAM76 PF16046.5 CDI81581.1 - 0.11 11.8 6.8 0.18 11.1 6.8 1.3 1 0 0 1 1 1 0 FAM76 protein Apt1 PF10351.9 CDI81581.1 - 0.26 10.1 10.5 0.35 9.7 10.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI81581.1 - 0.3 9.6 11.2 0.35 9.4 11.2 1.1 1 0 0 1 1 1 0 Macoilin family DUF572 PF04502.13 CDI81581.1 - 0.54 9.8 9.2 0.67 9.5 9.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lin-8 PF03353.15 CDI81581.1 - 9.3 5.7 12.5 13 5.3 12.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM176 PF14851.6 CDI81582.1 - 0.012 15.3 0.2 0.013 15.1 0.2 1.0 1 0 0 1 1 1 0 FAM176 family OSTbeta PF15048.6 CDI81582.1 - 0.067 13.3 0.0 0.077 13.1 0.0 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein TMEM51 PF15345.6 CDI81582.1 - 0.17 11.7 0.0 0.18 11.6 0.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 Cyt_c_ox_IV PF12270.8 CDI81582.1 - 0.24 11.6 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Pkinase PF00069.25 CDI81583.1 - 2.2e-17 63.3 0.0 5.8e-17 61.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI81583.1 - 2.8e-09 36.6 0.0 7.1e-09 35.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI81583.1 - 1.1e-08 34.7 0.0 2.1e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDI81583.1 - 0.0019 17.6 0.0 0.0038 16.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI81583.1 - 0.19 11.6 1.2 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_60s PF00428.19 CDI81583.1 - 6.3 7.5 22.2 1.9 9.2 5.6 3.8 4 0 0 4 4 4 0 60s Acidic ribosomal protein DEAD PF00270.29 CDI81584.1 - 3.1e-05 23.8 0.0 3.1e-05 23.8 0.0 2.9 2 2 0 2 2 2 1 DEAD/DEAH box helicase DUF572 PF04502.13 CDI81584.1 - 0.039 13.6 16.8 0.053 13.1 16.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) MMR1 PF08505.10 CDI81584.1 - 0.29 11.4 28.1 0.14 12.4 25.9 1.6 1 1 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_S64 PF08192.11 CDI81584.1 - 2.8 6.3 15.6 4 5.8 15.6 1.2 1 0 0 1 1 1 0 Peptidase family S64 CCDC106 PF15794.5 CDI81584.1 - 7.9 6.1 21.3 11 5.7 13.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 ketoacyl-synt PF00109.26 CDI81585.1 - 5.3e-75 252.3 0.4 1.3e-74 251.0 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CDI81585.1 - 2.1e-45 155.6 0.2 4.8e-45 154.4 0.2 1.6 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CDI81585.1 - 6.5e-45 153.6 1.1 1.1e-44 152.9 1.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CDI81585.1 - 1.4e-37 128.3 0.0 3.5e-37 127.0 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 CDI81585.1 - 2.9e-37 128.3 0.1 1.9e-36 125.7 0.1 2.3 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.26 CDI81585.1 - 3.6e-14 52.9 0.0 9.8e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.25 CDI81585.1 - 7.7e-14 51.8 0.0 1.8e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDI81585.1 - 3.7e-06 27.3 0.3 1.3e-05 25.6 0.1 2.0 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension ADH_N PF08240.12 CDI81585.1 - 5.5e-05 23.0 3.9 0.00021 21.2 0.2 3.1 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 CDI81585.1 - 0.00095 18.6 0.1 0.0019 17.6 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ADH_zinc_N_2 PF13602.6 CDI81585.1 - 0.0012 19.8 0.0 0.016 16.2 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CDI81585.1 - 0.033 13.7 0.8 0.19 11.1 0.0 2.7 4 0 0 4 4 4 0 short chain dehydrogenase SAT PF16073.5 CDI81585.1 - 0.1 12.3 0.2 2 8.1 0.2 2.4 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis efThoc1 PF11957.8 CDI81585.1 - 0.3 9.7 0.0 0.46 9.1 0.0 1.1 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor ACP_syn_III PF08545.10 CDI81585.1 - 0.33 10.8 2.2 7.3 6.5 0.4 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PT PF04886.12 CDI81590.1 - 0.034 13.7 9.3 0.034 13.7 9.3 5.2 2 1 4 6 6 6 0 PT repeat zf-CCCH PF00642.24 CDI81591.1 - 6.6e-09 35.5 14.1 3.7e-05 23.5 1.3 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDI81591.1 - 0.0088 15.8 2.8 0.0088 15.8 2.8 3.4 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CDI81591.1 - 0.015 15.5 1.6 0.015 15.5 1.6 4.1 4 1 1 5 5 5 0 Zinc-finger containing family EF1_GNE PF00736.19 CDI81592.1 - 1.6e-24 85.9 1.2 1.6e-24 85.9 1.2 1.9 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain PEGA PF08308.11 CDI81592.1 - 0.08 12.8 0.0 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 PEGA domain Telomere_Sde2_2 PF13297.6 CDI81593.1 - 0.056 13.1 0.1 0.16 11.6 0.1 1.8 1 0 0 1 1 1 0 Telomere stability C-terminal CAF1 PF04857.20 CDI81595.1 - 0.14 11.3 22.0 0.081 12.1 8.6 2.4 2 0 0 2 2 2 0 CAF1 family ribonuclease Adaptin_binding PF10199.9 CDI81596.1 - 0.0032 18.1 3.8 0.0032 18.1 3.8 3.7 3 0 0 3 3 3 1 Alpha and gamma adaptin binding protein p34 DUF4228 PF14009.6 CDI81596.1 - 0.013 15.9 0.8 0.013 15.9 0.8 5.3 4 3 0 4 4 4 0 Domain of unknown function (DUF4228) BTB_2 PF02214.22 CDI81596.1 - 0.13 12.6 0.0 0.47 10.8 0.0 2.0 1 1 0 1 1 1 0 BTB/POZ domain ketoacyl-synt PF00109.26 CDI81597.1 - 6e-72 242.3 0.1 9.9e-72 241.6 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CDI81597.1 - 2.4e-71 239.4 0.0 3.2e-36 124.9 0.0 2.4 2 0 0 2 2 2 2 KR domain Ketoacyl-synt_C PF02801.22 CDI81597.1 - 1.2e-41 141.4 0.0 2.3e-41 140.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CDI81597.1 - 1.5e-36 126.2 0.5 2.1e-36 125.7 0.5 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 CDI81597.1 - 8.4e-13 48.2 0.0 5.4e-09 35.8 0.0 3.1 3 0 0 3 3 3 2 short chain dehydrogenase PP-binding PF00550.25 CDI81597.1 - 9.3e-13 48.3 0.0 1.9e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 CDI81597.1 - 3e-12 46.7 0.0 8.9e-12 45.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDI81597.1 - 6.7e-10 40.1 0.0 1.8e-09 38.8 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CDI81597.1 - 6e-08 32.5 0.0 0.00064 19.4 0.0 2.8 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KAsynt_C_assoc PF16197.5 CDI81597.1 - 2e-06 28.2 0.0 8.5e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 CDI81597.1 - 1.7e-05 24.4 0.0 0.00014 21.5 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADH_N PF08240.12 CDI81597.1 - 5.6e-05 23.0 2.9 9.4e-05 22.3 0.0 2.8 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain Polysacc_synt_2 PF02719.15 CDI81597.1 - 0.0011 18.2 0.0 0.0023 17.1 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Thiolase_N PF00108.23 CDI81597.1 - 0.0036 16.7 0.1 0.0091 15.4 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain 3Beta_HSD PF01073.19 CDI81597.1 - 0.01 14.9 0.0 0.04 12.9 0.0 1.9 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family AlaDh_PNT_C PF01262.21 CDI81597.1 - 0.028 13.7 0.3 0.061 12.6 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FabA PF07977.13 CDI81597.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 FabA-like domain ELFV_dehydrog PF00208.21 CDI81597.1 - 0.33 10.6 1.4 3.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Spt20 PF12090.8 CDI81598.1 - 0.01 15.5 19.6 0.01 15.5 19.6 1.0 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI81598.1 - 0.044 14.7 4.7 0.042 14.8 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3371 PF11851.8 CDI81598.1 - 0.29 12.2 9.7 0.35 12.0 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) TFIIA PF03153.13 CDI81598.1 - 1.5 8.7 19.3 1.3 8.9 19.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GTA_holin_3TM PF11351.8 CDI81598.1 - 2.1 8.9 9.2 2.5 8.7 9.2 1.1 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release SpoIIIAH PF12685.7 CDI81599.1 - 0.0059 16.5 8.6 0.0059 16.5 8.6 3.3 2 1 0 2 2 2 1 SpoIIIAH-like protein DUF3742 PF12553.8 CDI81599.1 - 0.019 15.1 0.0 0.083 13.0 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) Thioredoxin_6 PF13848.6 CDI81603.1 - 2.4e-06 27.6 0.0 1e-05 25.6 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 CDI81603.1 - 5.2e-06 26.4 0.0 0.00012 22.1 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin C2 PF00168.30 CDI81605.1 - 2.4e-12 47.0 0.0 3.7e-09 36.8 0.0 3.4 3 0 0 3 3 3 2 C2 domain TFIIA PF03153.13 CDI81606.1 - 0.019 15.0 83.6 0.08 12.9 23.0 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MCU PF04678.13 CDI81606.1 - 0.65 10.1 8.4 4.5 7.3 0.6 2.5 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Fer4_22 PF17179.4 CDI81606.1 - 0.76 10.7 21.0 0.18 12.7 7.0 3.2 2 1 1 3 3 3 0 4Fe-4S dicluster domain Connexin PF00029.19 CDI81606.1 - 0.83 9.4 9.9 0.29 10.8 1.0 2.3 2 0 0 2 2 2 0 Connexin SpoIIP PF07454.11 CDI81606.1 - 1 8.7 16.4 0.25 10.8 7.9 2.6 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) OATP PF03137.20 CDI81606.1 - 2.1 6.5 7.3 0.18 10.1 0.5 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PA26 PF04636.13 CDI81606.1 - 6.7 5.5 15.8 2.8 6.7 1.1 2.3 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) FAM176 PF14851.6 CDI81606.1 - 8.2 6.1 12.2 3 7.5 5.7 3.0 2 0 0 2 2 2 0 FAM176 family Ion_trans PF00520.31 CDI81609.1 - 8.4e-10 38.3 3.8 1.3e-09 37.6 3.8 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 CDI81609.1 - 0.18 10.4 1.9 0.25 10.0 1.9 1.1 1 0 0 1 1 1 0 Polycystin cation channel RFC1 PF08519.12 CDI81610.1 - 1.8e-11 44.5 0.1 3.7e-05 23.9 0.0 2.2 1 1 1 2 2 2 2 Replication factor RFC1 C terminal domain RR_TM4-6 PF06459.12 CDI81610.1 - 0.18 11.6 3.4 0.28 11.0 3.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cadherin_C_2 PF16492.5 CDI81613.1 - 1.7 9.4 9.6 13 6.6 3.0 3.7 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal Helicase_C PF00271.31 CDI81614.1 - 1.4e-12 47.9 2.9 1.6e-12 47.8 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain PTCB-BRCT PF12738.7 CDI81616.1 - 1.8e-06 27.8 0.1 3.2e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 CDI81616.1 - 4.9e-05 23.6 0.0 8.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF1635 PF07795.11 CDI81616.1 - 0.51 10.1 5.4 0.83 9.5 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Nup54_57_C PF18570.1 CDI81616.1 - 0.71 9.5 1.8 1.1 8.9 1.8 1.3 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain Beta-lactamase2 PF13354.6 CDI81618.1 - 3e-39 134.7 0.0 3.8e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase enzyme family Beta-lactamase PF00144.24 CDI81618.1 - 6.8e-30 104.4 0.0 1.3e-29 103.5 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 CDI81618.1 - 1.9e-06 27.5 0.0 4.3e-06 26.4 0.0 1.5 1 1 1 2 2 2 1 D-alanyl-D-alanine carboxypeptidase GFP PF01353.22 CDI81619.1 - 2.3e-98 328.1 0.7 2.7e-98 327.9 0.7 1.0 1 0 0 1 1 1 1 Green fluorescent protein RNA_pol_Rpb2_6 PF00562.28 CDI81621.1 - 2.7e-115 385.6 0.0 3.5e-115 385.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 CDI81621.1 - 1.6e-19 70.1 0.0 3.1e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CDI81621.1 - 4.3e-05 23.6 0.1 0.00011 22.3 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 NUC153 PF08159.12 CDI81622.1 - 4.9e-08 32.7 0.2 9.6e-08 31.7 0.2 1.5 1 0 0 1 1 1 1 NUC153 domain RskA PF10099.9 CDI81622.1 - 0.29 11.4 24.3 5.9 7.2 10.3 4.3 2 1 1 3 3 3 0 Anti-sigma-K factor rskA eIF3_subunit PF08597.10 CDI81625.1 - 2.9 7.7 13.7 4.4 7.2 13.7 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PUA_3 PF17785.1 CDI81626.1 - 4.4e-10 39.2 0.1 3.6e-08 33.1 0.1 2.4 1 1 0 1 1 1 1 PUA-like domain Pox_A12 PF04651.13 CDI81627.1 - 0.00085 19.4 1.2 0.002 18.2 1.2 1.5 1 0 0 1 1 1 1 Poxvirus A12 protein SUIM_assoc PF16619.5 CDI81627.1 - 0.018 15.1 2.2 0.018 15.1 2.2 7.3 4 1 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 GATase PF00117.28 CDI81629.1 - 1.4e-21 77.1 0.0 4.6e-21 75.5 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDI81629.1 - 7.2e-06 25.9 0.2 0.00039 20.2 0.0 2.3 2 0 0 2 2 2 1 Peptidase C26 NAD_synthase PF02540.17 CDI81629.1 - 2.8e-05 23.4 0.0 4.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 CDI81629.1 - 0.0011 17.8 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 CDI81629.1 - 0.0014 18.3 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 CDI81629.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 CDI81629.1 - 0.093 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase ATP_bind_3 PF01171.20 CDI81629.1 - 0.23 11.2 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 PP-loop family Ribosomal_60s PF00428.19 CDI81629.1 - 0.3 11.7 5.2 0.97 10.1 5.2 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein FliE PF02049.18 CDI81631.1 - 0.03 14.5 2.0 2.6 8.3 0.5 2.8 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE LMBR1 PF04791.16 CDI81631.1 - 0.25 10.2 0.0 3.1 6.6 0.2 1.9 1 1 1 2 2 2 0 LMBR1-like membrane protein GREB1 PF15782.5 CDI81637.1 - 0.099 9.8 34.2 0.12 9.4 34.2 1.4 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ASC PF00858.24 CDI81637.1 - 8.1 5.3 12.5 0.69 8.8 0.8 2.2 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel UPF0172 PF03665.13 CDI81638.1 - 4.2e-16 59.6 0.0 9.6e-16 58.4 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 CDI81638.1 - 0.13 12.3 0.1 0.25 11.3 0.0 1.6 2 0 0 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF1645 PF07816.11 CDI81642.1 - 0.014 16.0 13.3 0.014 16.0 13.3 5.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1645) Diacid_rec PF05651.13 CDI81642.1 - 0.14 11.8 0.1 0.14 11.8 0.1 4.2 4 0 0 4 4 4 0 Putative sugar diacid recognition Peptidase_S49_N PF08496.10 CDI81642.1 - 5.2 7.1 26.8 2.9 7.9 2.3 4.5 4 0 0 4 4 4 0 Peptidase family S49 N-terminal DUF4776 PF16003.5 CDI81643.1 - 6 5.7 11.3 9.1 5.1 10.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4776) Peptidase_S64 PF08192.11 CDI81643.1 - 10 4.5 22.2 14 4.0 22.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 MFS_1 PF07690.16 CDI81644.1 - 2.3e-14 53.1 43.3 2.1e-11 43.4 22.2 3.0 3 2 0 3 3 3 2 Major Facilitator Superfamily OAD_gamma PF04277.13 CDI81644.1 - 0.0018 18.8 0.6 19 5.9 0.0 3.6 3 0 0 3 3 3 2 Oxaloacetate decarboxylase, gamma chain DUF3775 PF12616.8 CDI81644.1 - 0.11 12.5 1.8 11 6.2 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3775) BatD PF13584.6 CDI81644.1 - 0.45 9.3 1.1 19 3.9 0.1 2.3 2 0 0 2 2 2 0 Oxygen tolerance Aconitase_2_N PF06434.13 CDI81646.1 - 0.4 10.3 2.2 0.48 10.0 0.1 1.8 1 1 1 2 2 2 0 Aconitate hydratase 2 N-terminus TFIIA PF03153.13 CDI81646.1 - 0.45 10.5 53.7 0.75 9.7 53.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FapA PF03961.13 CDI81646.1 - 2 6.9 16.0 2.2 6.8 16.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Dala_Dala_lig_N PF01820.21 CDI81646.1 - 2.2 8.8 6.9 12 6.4 6.9 1.9 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus DUF4746 PF15928.5 CDI81646.1 - 2.5 7.5 13.1 3 7.2 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Exonuc_VII_L PF02601.15 CDI81646.1 - 3.1 7.3 28.1 3.8 7.0 28.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PIG-S PF10510.9 CDI81646.1 - 5.3 5.8 22.4 6.5 5.5 22.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein MAJIN PF15077.6 CDI81646.1 - 6 6.6 13.1 7.2 6.3 13.1 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein CLN3 PF02487.17 CDI81646.1 - 6.4 5.7 10.8 7.5 5.5 10.8 1.4 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.16 CDI81646.1 - 8.6 6.3 17.4 11 6.0 17.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 CDI81646.1 - 9.3 4.9 17.4 10 4.8 17.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TFIIA PF03153.13 CDI81647.1 - 0.23 11.4 31.3 0.29 11.1 31.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TipE PF16972.5 CDI81647.1 - 3.7 6.6 5.6 4.4 6.4 5.6 1.1 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE HEPPP_synt_1 PF07307.11 CDI81647.1 - 6.5 6.3 10.8 0.54 9.8 5.1 1.9 1 1 1 2 2 2 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Cofilin_ADF PF00241.20 CDI81648.1 - 0.051 13.4 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Lzipper-MIP1 PF14389.6 CDI81650.1 - 0.015 15.6 1.2 0.015 15.6 1.2 2.1 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 RCC1 PF00415.18 CDI81650.1 - 0.018 15.6 0.1 0.039 14.6 0.1 1.6 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat ABC_tran_CTD PF16326.5 CDI81650.1 - 0.027 14.7 2.9 0.027 14.7 2.9 2.5 3 1 0 3 3 3 0 ABC transporter C-terminal domain BBP1_C PF15272.6 CDI81650.1 - 0.033 14.0 4.6 0.073 12.9 4.6 1.5 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal RGCC PF15151.6 CDI81650.1 - 0.24 11.6 6.4 0.17 12.1 3.9 1.8 1 1 0 2 2 2 0 Response gene to complement 32 protein family DUF572 PF04502.13 CDI81650.1 - 0.27 10.8 3.2 0.35 10.4 3.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Use1 PF09753.9 CDI81650.1 - 6.1 6.5 9.4 12 5.5 9.4 1.5 1 1 0 1 1 1 0 Membrane fusion protein Use1 ANAPC1 PF12859.7 CDI81650.1 - 6.6 7.3 7.9 1.6 9.3 4.5 1.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 1 SR-25 PF10500.9 CDI81651.1 - 0.0017 18.0 28.7 0.0017 18.0 28.7 5.2 5 0 0 5 5 5 4 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI81651.1 - 0.01 16.1 11.8 0.01 16.1 11.8 6.7 2 2 3 5 5 5 0 Anti-sigma-K factor rskA FliD_N PF02465.18 CDI81654.1 - 0.0089 16.7 0.5 0.0089 16.7 0.5 9.8 6 2 4 10 10 10 2 Flagellar hook-associated protein 2 N-terminus EutA PF06277.11 CDI81655.1 - 0.025 13.4 0.3 0.036 12.9 0.3 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA Presenilin PF01080.17 CDI81655.1 - 0.79 8.4 3.8 0.86 8.3 3.8 1.0 1 0 0 1 1 1 0 Presenilin MCM PF00493.23 CDI81658.1 - 5e-35 120.6 0.1 7.6e-35 120.0 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDI81658.1 - 1.3e-17 63.9 0.0 2.9e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_3 PF07726.11 CDI81658.1 - 0.044 13.6 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDI81658.1 - 0.086 12.2 0.0 0.19 11.1 0.0 1.5 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI SUIM_assoc PF16619.5 CDI81659.1 - 0.18 11.9 20.2 0.84 9.8 7.5 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI81659.1 - 0.45 10.1 13.0 0.76 9.3 13.0 1.3 1 0 0 1 1 1 0 Spt20 family bMG6 PF17962.1 CDI81659.1 - 5.9 7.1 8.0 0.17 12.1 0.8 2.0 2 0 0 2 2 2 0 Bacterial macroglobulin domain 6 NGP1NT PF08153.12 CDI81663.1 - 1.8e-35 121.9 0.1 4e-35 120.8 0.0 1.6 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CDI81663.1 - 1e-15 57.8 0.0 6e-13 48.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI81663.1 - 2.8e-07 30.6 0.0 6.9e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 CDI81663.1 - 2.8e-05 23.7 0.1 0.0037 16.8 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDI81663.1 - 0.00037 20.1 0.1 0.0045 16.6 0.1 2.3 1 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CDI81663.1 - 0.00046 19.7 0.0 0.81 9.1 0.1 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_16 PF13191.6 CDI81663.1 - 0.12 12.8 0.1 5.6 7.3 0.0 2.5 1 1 1 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 CDI81663.1 - 0.12 12.4 0.3 7.1 6.7 0.0 2.9 2 1 1 3 3 3 0 Dynamin family Lactamase_B PF00753.27 CDI81664.1 - 3.1e-06 27.3 0.0 2.3e-05 24.5 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDI81664.1 - 0.015 14.8 0.0 0.033 13.7 0.0 1.8 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Sin_N PF04801.13 CDI81665.1 - 2.2e-09 37.1 24.6 1.2e-05 24.7 0.0 5.0 5 1 0 5 5 5 3 Sin-like protein conserved region DUF2722 PF10846.8 CDI81665.1 - 0.00057 18.9 8.0 0.00057 18.9 8.0 7.8 6 2 1 8 8 8 2 Protein of unknown function (DUF2722) DUF4647 PF15504.6 CDI81676.1 - 0.00013 21.3 2.3 0.00014 21.1 2.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) Spt20 PF12090.8 CDI81676.1 - 0.0024 17.5 16.4 0.0043 16.7 16.4 1.4 1 0 0 1 1 1 1 Spt20 family NPR3 PF03666.13 CDI81676.1 - 0.0065 15.3 3.7 0.0087 14.9 3.7 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Plasmodium_Vir PF05795.11 CDI81676.1 - 0.02 14.4 3.2 0.025 14.0 3.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein OATP PF03137.20 CDI81676.1 - 0.047 12.0 0.2 0.059 11.7 0.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TRAM_LAG1_CLN8 PF03798.16 CDI81676.1 - 0.051 13.3 0.1 0.081 12.7 0.1 1.5 1 0 0 1 1 1 0 TLC domain Presenilin PF01080.17 CDI81676.1 - 0.074 11.8 6.3 0.092 11.5 6.3 1.2 1 0 0 1 1 1 0 Presenilin MMR1 PF08505.10 CDI81676.1 - 0.095 13.0 7.7 0.12 12.7 7.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NST1 PF13945.6 CDI81676.1 - 0.1 12.7 13.4 0.16 12.1 13.4 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Neur_chan_memb PF02932.16 CDI81676.1 - 0.15 12.1 2.2 0.19 11.7 2.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 CDI81676.1 - 0.2 9.7 4.9 0.22 9.6 4.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SOG2 PF10428.9 CDI81676.1 - 0.25 10.5 11.3 0.29 10.3 11.3 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2722 PF10846.8 CDI81676.1 - 0.29 10.0 14.0 0.41 9.5 14.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) IER PF05760.12 CDI81676.1 - 0.31 11.3 13.9 0.43 10.8 13.9 1.2 1 0 0 1 1 1 0 Immediate early response protein (IER) MPM1 PF17234.2 CDI81676.1 - 0.57 10.4 11.0 0.82 9.9 11.0 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Gti1_Pac2 PF09729.9 CDI81676.1 - 0.73 9.9 6.5 1.1 9.3 6.5 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family SUIM_assoc PF16619.5 CDI81676.1 - 0.75 9.9 20.2 2.3 8.3 20.2 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TERB2 PF15101.6 CDI81676.1 - 0.81 9.7 9.0 1.3 9.1 9.0 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CLN3 PF02487.17 CDI81676.1 - 1.4 7.9 6.5 2.1 7.3 6.5 1.3 1 1 0 1 1 1 0 CLN3 protein Spore_coat_CotO PF14153.6 CDI81676.1 - 1.4 8.8 13.8 1.9 8.4 13.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Herpes_DNAp_acc PF04929.12 CDI81676.1 - 1.6 7.6 8.1 2.4 7.1 8.1 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF966 PF06136.13 CDI81676.1 - 2 8.0 8.3 2.4 7.8 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) BRF1 PF07741.13 CDI81676.1 - 3.2 8.1 10.1 7.2 7.0 10.1 1.6 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DUF2052 PF09747.9 CDI81676.1 - 3.8 7.6 11.9 5.4 7.1 11.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) UPF0242 PF06785.11 CDI81678.1 - 0.28 11.3 5.3 0.56 10.3 5.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 CDI81678.1 - 0.38 9.6 7.8 0.57 9.0 7.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 CDI81678.1 - 0.98 9.7 7.2 2.2 8.5 7.2 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding rRNA_processing PF08524.11 CDI81680.1 - 0.00027 21.0 61.0 0.0084 16.1 50.1 4.0 1 1 1 2 2 2 1 rRNA processing Di19_C PF14571.6 CDI81680.1 - 0.029 14.9 1.3 0.029 14.9 1.3 3.7 4 1 0 4 4 4 0 Stress-induced protein Di19, C-terminal YL1 PF05764.13 CDI81680.1 - 0.095 12.8 35.3 0.83 9.7 18.5 2.3 2 0 0 2 2 2 0 YL1 nuclear protein FAM91_C PF14648.6 CDI81680.1 - 0.36 9.6 4.6 0.61 8.9 4.6 1.4 1 0 0 1 1 1 0 FAM91 C-terminus LapA_dom PF06305.11 CDI81682.1 - 0.11 12.4 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PCMT PF01135.19 CDI81685.1 - 2e-21 76.7 0.0 3.9e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Spt20 PF12090.8 CDI81685.1 - 0.0049 16.5 0.2 0.0054 16.4 0.2 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI81685.1 - 0.021 14.9 0.5 0.021 14.8 0.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4179 PF13786.6 CDI81685.1 - 0.062 13.8 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) SUIM_assoc PF16619.5 CDI81685.1 - 0.27 11.4 8.4 0.48 10.5 8.4 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PCMT PF01135.19 CDI81686.1 - 7.9e-31 107.4 0.2 9.3e-27 94.1 0.1 2.1 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CDI81686.1 - 0.37 10.8 2.2 0.54 10.2 0.1 1.9 1 1 1 2 2 2 0 Methyltransferase domain DUF1180 PF06679.12 CDI81686.1 - 0.69 10.3 6.0 1.1 9.7 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Apt1 PF10351.9 CDI81686.1 - 3.2 6.5 5.8 4.1 6.2 5.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3395 PF11875.8 CDI81687.1 - 3.3e-11 43.3 7.1 3.2e-10 40.1 7.1 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3395) SOG2 PF10428.9 CDI81687.1 - 0.13 11.4 32.1 0.1 11.8 12.6 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein SPX PF03105.19 CDI81687.1 - 1.1 9.1 27.6 0.75 9.7 15.2 2.5 2 0 0 2 2 2 0 SPX domain Apt1 PF10351.9 CDI81687.1 - 1.9 7.3 24.4 0.6 8.9 10.4 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF572 PF04502.13 CDI81687.1 - 3 7.4 14.6 0.26 10.9 8.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Smg8_Smg9 PF10220.9 CDI81687.1 - 6.1 5.0 6.6 13 3.9 6.6 1.5 1 0 0 1 1 1 0 Smg8_Smg9 Flavokinase PF01687.17 CDI81690.1 - 8.8e-11 42.1 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Riboflavin kinase M_domain PF12938.7 CDI81690.1 - 0.025 14.4 2.3 0.025 14.4 2.3 5.3 4 1 0 5 5 5 0 M domain of GW182 CGI-121 PF08617.10 CDI81690.1 - 0.11 12.7 1.1 0.29 11.2 1.1 1.7 1 0 0 1 1 1 0 Kinase binding protein CGI-121 SUIM_assoc PF16619.5 CDI81690.1 - 1.5 8.9 50.0 0.3 11.2 5.6 4.7 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Dynamin_N PF00350.23 CDI81692.1 - 5.2e-15 55.9 0.0 3.9e-14 53.1 0.0 2.0 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 CDI81692.1 - 2.7e-14 52.8 0.7 4.7e-14 52.0 0.7 1.4 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 CDI81692.1 - 1.5e-07 31.5 0.0 2.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDI81692.1 - 6e-06 25.9 0.0 0.0022 17.6 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 CDI81692.1 - 8.4e-05 22.8 0.0 0.44 10.8 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 CDI81692.1 - 0.00041 20.3 0.0 0.12 12.2 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase PduV-EutP PF10662.9 CDI81692.1 - 0.0098 15.6 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 CDI81692.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 CDI81692.1 - 0.022 14.1 0.0 0.05 12.9 0.0 1.6 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Septin PF00735.18 CDI81692.1 - 0.049 12.9 0.0 0.34 10.1 0.0 1.9 2 0 0 2 2 2 0 Septin cobW PF02492.19 CDI81692.1 - 0.067 12.8 0.0 11 5.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ras PF00071.22 CDI81692.1 - 0.12 12.0 0.0 13 5.3 0.0 2.2 2 0 0 2 2 2 0 Ras family AAA_16 PF13191.6 CDI81692.1 - 0.15 12.5 0.0 0.36 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CDI81692.1 - 0.2 11.8 0.0 1 9.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain RIO1 PF01163.22 CDI81693.1 - 1.7e-42 145.2 0.2 3.3e-42 144.2 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDI81693.1 - 6.7e-08 32.7 6.9 0.0015 18.5 0.2 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 CDI81693.1 - 1.3e-06 28.0 0.4 1.8e-05 24.2 0.4 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.11 CDI81693.1 - 0.02 14.5 0.1 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_fungal PF17667.1 CDI81693.1 - 0.79 8.4 7.2 0.18 10.5 0.1 2.2 2 0 0 2 2 2 0 Fungal protein kinase SDA1 PF05285.12 CDI81693.1 - 5.6 6.3 24.7 8.9 5.6 24.7 1.3 1 0 0 1 1 1 0 SDA1 LAP1C PF05609.12 CDI81693.1 - 8 5.4 19.6 10 5.1 19.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) STI1 PF17830.1 CDI81694.1 - 0.00022 21.1 0.5 0.00078 19.3 0.4 1.8 1 1 0 1 1 1 1 STI1 domain GerD PF17898.1 CDI81694.1 - 0.0034 17.3 0.1 0.0045 16.9 0.1 1.2 1 0 0 1 1 1 1 Spore germination GerD central core domain ComC PF03047.14 CDI81694.1 - 0.081 12.7 0.5 14 5.6 0.1 2.6 2 0 0 2 2 2 0 COMC family Sulfate_transp PF00916.20 CDI81696.1 - 0.019 13.7 0.8 0.028 13.2 0.8 1.2 1 0 0 1 1 1 0 Sulfate permease family eIF3_subunit PF08597.10 CDI81696.1 - 0.025 14.5 5.3 0.042 13.8 5.3 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SpoIIP PF07454.11 CDI81696.1 - 0.027 13.9 2.2 0.039 13.4 2.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Exonuc_VII_L PF02601.15 CDI81696.1 - 0.051 13.1 6.8 0.071 12.7 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit EMC3_TMCO1 PF01956.16 CDI81696.1 - 0.11 12.2 3.3 0.16 11.7 3.3 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF3464 PF11947.8 CDI81696.1 - 0.17 11.7 5.7 0.37 10.5 5.7 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Connexin PF00029.19 CDI81696.1 - 0.29 10.9 2.8 0.47 10.2 2.8 1.3 1 0 0 1 1 1 0 Connexin DUF1980 PF09323.10 CDI81696.1 - 0.57 10.1 4.9 0.07 13.0 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF4407 PF14362.6 CDI81696.1 - 1.1 8.6 6.3 2.2 7.6 6.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PAT1 PF09770.9 CDI81696.1 - 1.2 7.3 12.8 1.5 7.0 12.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3292 PF11696.8 CDI81696.1 - 1.5 7.1 6.9 2.2 6.5 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) PA26 PF04636.13 CDI81696.1 - 1.8 7.4 4.9 2.6 6.9 4.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) V_ATPase_I PF01496.19 CDI81696.1 - 2.2 6.1 7.9 2.9 5.7 7.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-3_zeta PF05091.12 CDI81696.1 - 3.2 6.6 9.1 4.2 6.2 9.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Neur_chan_memb PF02932.16 CDI81696.1 - 4.3 7.3 6.9 0.41 10.7 1.8 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EIIBC-GUT_N PF03612.14 CDI81696.1 - 4.6 6.9 6.6 8 6.2 6.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Peptidase_S49_N PF08496.10 CDI81696.1 - 5.5 7.0 10.8 7.4 6.6 10.0 1.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4050 PF13259.6 CDI81696.1 - 9.5 6.5 13.3 2.4 8.5 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Ufd2P_core PF10408.9 CDI81697.1 - 3.9e-73 247.1 0.0 7.4e-42 143.8 0.0 3.1 2 1 1 3 3 3 3 Ubiquitin elongating factor core U-box PF04564.15 CDI81697.1 - 4.5e-27 94.0 1.3 9.7e-27 93.0 1.3 1.6 1 0 0 1 1 1 1 U-box domain DUF4874 PF16173.5 CDI81698.1 - 0.064 12.9 0.3 0.15 11.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) DUF5408 PF17402.2 CDI81698.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5408) CitG PF01874.16 CDI81698.1 - 1.1 8.9 6.0 2 8.0 4.7 2.1 1 1 1 2 2 2 0 ATP:dephospho-CoA triphosphoribosyl transferase Glyco_hydro_65m PF03632.15 CDI81698.1 - 1.3 7.8 5.5 0.18 10.6 1.2 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 65 central catalytic domain PIH1 PF08190.12 CDI81701.1 - 1.3e-15 57.3 0.0 2.5e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 PIH1 N-terminal domain zf-Tim10_DDP PF02953.15 CDI81702.1 - 4.8e-14 51.8 7.2 1.5e-13 50.2 7.2 1.7 1 1 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 CDI81702.1 - 0.056 13.1 3.9 0.093 12.4 3.9 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DUF1039 PF06287.11 CDI81702.1 - 0.086 13.3 0.3 0.13 12.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1039) RskA PF10099.9 CDI81703.1 - 3.3 8.0 24.1 1.3 9.3 11.0 2.4 2 0 0 2 2 2 0 Anti-sigma-K factor rskA UPF0020 PF01170.18 CDI81706.1 - 5.4e-05 23.0 0.0 5.4e-05 23.0 0.0 2.3 2 1 0 2 2 1 1 Putative RNA methylase family UPF0020 DDHD PF02862.17 CDI81706.1 - 0.00088 19.5 19.2 0.026 14.7 5.7 3.3 3 0 0 3 3 3 2 DDHD domain RskA PF10099.9 CDI81706.1 - 0.0051 17.1 2.0 0.0051 17.1 2.0 6.3 3 3 2 6 6 4 1 Anti-sigma-K factor rskA DUF2052 PF09747.9 CDI81706.1 - 0.036 14.2 25.3 0.046 13.8 7.1 3.5 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) EPL1 PF10513.9 CDI81706.1 - 0.14 12.5 34.3 0.21 11.9 8.4 3.6 4 0 0 4 4 4 0 Enhancer of polycomb-like Lin-8 PF03353.15 CDI81706.1 - 0.15 11.6 35.8 0.05 13.2 11.9 3.2 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist SUIM_assoc PF16619.5 CDI81706.1 - 1 9.5 0.0 0.028 14.5 3.9 7.6 5 2 0 5 5 2 0 Unstructured region C-term to UIM in Ataxin3 SpoIIP PF07454.11 CDI81706.1 - 1.2 8.5 31.3 0.061 12.8 10.2 3.2 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 CDI81706.1 - 1.4 7.8 23.7 0.068 12.2 6.9 3.1 3 0 0 3 3 3 0 Solute carrier family 12 HNOBA PF07701.14 CDI81706.1 - 1.5 8.2 17.0 0.48 9.8 5.7 3.1 3 0 0 3 3 3 0 Heme NO binding associated Endostatin PF06482.11 CDI81706.1 - 2.1 7.7 26.7 2.6 7.4 12.1 3.2 3 0 0 3 3 3 0 Collagenase NC10 and Endostatin Nha1_C PF08619.10 CDI81706.1 - 3.5 6.7 29.0 0.18 11.0 7.2 3.2 3 0 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus DUF4820 PF16091.5 CDI81706.1 - 4.1 6.7 23.2 0.3 10.4 4.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) Velvet PF11754.8 CDI81706.1 - 4.7 7.1 26.9 0.61 10.0 8.2 3.3 3 0 0 3 3 3 0 Velvet factor Presenilin PF01080.17 CDI81706.1 - 8.5 5.0 38.9 0.2 10.4 13.1 3.2 3 0 0 3 3 3 0 Presenilin UQ_con PF00179.26 CDI81712.1 - 3.4e-40 136.9 0.1 5.2e-40 136.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Peptidase_S49_N PF08496.10 CDI81712.1 - 0.24 11.5 3.0 0.32 11.1 3.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RRS1 PF04939.12 CDI81714.1 - 1.6e-31 109.4 5.5 1e-30 106.7 5.5 2.0 1 1 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) SUIM_assoc PF16619.5 CDI81715.1 - 0.0086 16.1 0.3 0.0086 16.1 0.3 4.9 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Activator_LAG-3 PF11498.8 CDI81717.1 - 0.58 9.1 44.4 0.81 8.6 44.4 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 CDI81717.1 - 2.3 8.1 35.4 3.3 7.6 35.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Helicase_C PF00271.31 CDI81718.1 - 2.6e-10 40.6 0.0 2.1e-09 37.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HA2 PF04408.23 CDI81718.1 - 7.3e-10 39.1 0.1 7.3e-10 39.1 0.1 7.0 7 1 0 7 7 7 1 Helicase associated domain (HA2) Utp14 PF04615.13 CDI81718.1 - 0.00061 18.5 8.8 0.00061 18.5 8.8 3.5 3 0 0 3 3 3 1 Utp14 protein DUF5308 PF17233.2 CDI81718.1 - 0.0049 17.1 0.5 0.0049 17.1 0.5 9.6 8 2 0 8 8 8 2 Family of unknown function (DUF5308) RskA PF10099.9 CDI81718.1 - 0.0079 16.5 0.0 0.0079 16.5 0.0 11.2 6 3 3 9 9 9 1 Anti-sigma-K factor rskA RsgA_GTPase PF03193.16 CDI81718.1 - 0.057 13.3 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase BCS1_N PF08740.11 CDI81719.1 - 9.7e-21 74.6 2.6 2e-20 73.6 0.0 2.2 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 CDI81719.1 - 2.6e-13 50.5 0.0 1.4e-11 44.9 0.0 2.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI81719.1 - 0.00036 20.9 6.4 0.00086 19.7 3.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 CDI81719.1 - 0.00038 20.3 7.4 0.031 14.0 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 CDI81719.1 - 0.0073 16.5 1.9 0.035 14.3 0.0 2.7 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CDI81719.1 - 0.012 15.2 0.0 0.031 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDI81719.1 - 0.017 15.1 0.8 0.043 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PPV_E1_C PF00519.17 CDI81719.1 - 0.022 13.6 0.2 0.073 11.9 0.0 1.7 2 0 0 2 2 2 0 Papillomavirus helicase RNA_helicase PF00910.22 CDI81719.1 - 0.091 13.2 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 CDI81719.1 - 0.1 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 CDI81719.1 - 0.15 12.6 0.6 0.7 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Hydin_ADK PF17213.3 CDI81719.1 - 0.18 12.1 9.0 6.7 6.9 4.2 3.1 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_22 PF13401.6 CDI81719.1 - 0.33 11.2 0.0 0.33 11.2 0.0 2.5 3 0 0 3 3 1 0 AAA domain ABC_tran PF00005.27 CDI81719.1 - 0.37 11.3 5.3 0.43 11.1 0.0 2.7 3 0 0 3 3 3 0 ABC transporter DDHD PF02862.17 CDI81719.1 - 0.38 10.9 4.3 1.7 8.8 3.9 1.9 2 0 0 2 2 2 0 DDHD domain TFIIA PF03153.13 CDI81719.1 - 0.42 10.6 22.5 2.5 8.0 17.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_28 PF13521.6 CDI81719.1 - 0.61 10.3 0.0 0.61 10.3 0.0 3.0 3 0 0 3 3 2 0 AAA domain Ctr PF04145.15 CDI81719.1 - 3.2 8.4 4.9 14 6.3 3.2 2.3 2 0 0 2 2 2 0 Ctr copper transporter family AAA_23 PF13476.6 CDI81719.1 - 5.7 7.4 14.5 34 4.9 8.2 2.9 3 0 0 3 3 3 0 AAA domain DUF4407 PF14362.6 CDI81719.1 - 7.4 5.8 12.2 1.8 7.8 7.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Pribosyltran_N PF13793.6 CDI81720.1 - 4.1e-48 162.2 0.1 2.5e-47 159.6 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDI81720.1 - 1.9e-35 122.6 1.2 3.6e-35 121.7 1.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDI81720.1 - 1.2e-12 47.6 0.2 2.5e-12 46.6 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDI81720.1 - 0.0015 18.0 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase LEP503 PF15221.6 CDI81720.1 - 0.19 12.0 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 Lens epithelial cell protein LEP503 ANAPC4_WD40 PF12894.7 CDI81722.1 - 1.7e-08 34.7 0.4 0.0058 16.9 0.1 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 CDI81722.1 - 0.0021 17.8 0.2 0.0089 15.8 0.2 2.2 1 0 0 1 1 1 1 HIRA B motif WD40 PF00400.32 CDI81722.1 - 0.23 12.4 9.1 11 7.1 0.6 4.9 4 0 0 4 4 4 0 WD domain, G-beta repeat Caldesmon PF02029.15 CDI81726.1 - 2 7.1 86.0 2.8 6.6 86.0 1.1 1 0 0 1 1 1 0 Caldesmon DXP_synthase_N PF13292.6 CDI81727.1 - 9.1e-54 182.5 0.4 2.8e-53 180.9 0.0 2.1 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDI81727.1 - 1.1e-31 109.9 3.4 1.3e-31 109.7 0.0 2.7 2 1 0 2 2 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDI81727.1 - 1.9e-10 40.7 1.9 2.3e-09 37.2 0.0 2.9 2 1 0 2 2 2 1 Transketolase, C-terminal domain Transketolase_N PF00456.21 CDI81727.1 - 3.8e-06 26.1 1.2 0.036 13.0 0.0 2.4 2 0 0 2 2 2 2 Transketolase, thiamine diphosphate binding domain DUF2722 PF10846.8 CDI81727.1 - 0.00047 19.2 16.0 0.03 13.3 9.9 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) DUF4207 PF13904.6 CDI81727.1 - 0.00067 19.4 9.7 0.00067 19.4 9.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4207) E1_dh PF00676.20 CDI81727.1 - 0.0012 17.9 0.0 0.0012 17.9 0.0 2.3 2 0 0 2 2 1 1 Dehydrogenase E1 component SR-25 PF10500.9 CDI81727.1 - 0.0039 16.8 6.9 0.0039 16.8 6.9 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Coilin_N PF15862.5 CDI81727.1 - 0.33 10.7 10.4 0.11 12.2 3.7 2.2 2 0 0 2 2 2 0 Coilin N-terminus SpoIIP PF07454.11 CDI81727.1 - 2.4 7.5 7.7 0.24 10.8 1.7 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Activator_LAG-3 PF11498.8 CDI81727.1 - 7.9 5.3 33.7 2.3 7.1 17.6 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 EPL1 PF10513.9 CDI81727.1 - 8.4 6.8 12.2 1.5 9.2 4.2 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like GREB1 PF15782.5 CDI81727.1 - 9.6 3.2 7.9 0.32 8.1 2.1 1.3 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer zf-C2H2_11 PF16622.5 CDI81728.1 - 1.7 8.5 12.5 4.7 7.0 0.7 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type SLC12 PF03522.15 CDI81728.1 - 2.3 7.2 41.7 0.42 9.6 34.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 DUF572 PF04502.13 CDI81728.1 - 2.6 7.6 43.0 4.6 6.8 34.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) BAF1_ABF1 PF04684.13 CDI81728.1 - 4.9 6.1 39.8 0.24 10.4 28.0 2.4 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PA26 PF04636.13 CDI81728.1 - 7.4 5.4 29.3 1.2 8.0 23.2 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Archease PF01951.16 CDI81729.1 - 2.5e-42 144.4 0.4 5.1e-42 143.4 0.4 1.6 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) MDM10 PF12519.8 CDI81729.1 - 0.00015 20.8 5.4 0.0002 20.4 5.4 1.1 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 DUF4571 PF15137.6 CDI81729.1 - 0.0011 18.7 7.1 0.056 13.1 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4571) HA2 PF04408.23 CDI81729.1 - 0.14 12.5 8.5 0.19 12.0 0.3 3.1 3 0 0 3 3 3 0 Helicase associated domain (HA2) Presenilin PF01080.17 CDI81729.1 - 0.19 10.4 17.7 0.034 12.9 9.9 2.1 2 0 0 2 2 2 0 Presenilin Mss4 PF04421.13 CDI81729.1 - 2.2 8.5 9.2 0.62 10.2 0.4 2.3 2 0 0 2 2 2 0 Mss4 protein Rpp20 PF12328.8 CDI81729.1 - 2.4 8.1 13.4 2.8 7.9 1.0 2.4 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Roughex PF06020.11 CDI81729.1 - 2.9 6.9 18.3 0.38 9.8 4.9 2.3 2 0 0 2 2 2 0 Drosophila roughex protein XRN_N PF03159.18 CDI81729.1 - 6.7 6.1 18.3 6.3 6.2 0.1 2.6 2 1 1 3 3 3 0 XRN 5'-3' exonuclease N-terminus DUF4407 PF14362.6 CDI81729.1 - 7 5.9 23.7 0.33 10.3 14.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Hydin_ADK PF17213.3 CDI81729.1 - 8.5 6.6 23.5 2.4 8.4 10.9 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF2489 PF10675.9 CDI81729.1 - 9.9 6.1 24.5 3.1 7.7 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DEAD PF00270.29 CDI81730.1 - 2.4e-35 121.9 0.0 3.4e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase SPRY PF00622.28 CDI81730.1 - 0.0018 18.4 0.0 0.0085 16.2 0.0 1.8 1 1 0 1 1 1 1 SPRY domain ResIII PF04851.15 CDI81730.1 - 0.05 13.6 0.0 7 6.6 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Ribosomal_L28e PF01778.17 CDI81732.1 - 2.1e-20 73.6 2.1 2.4e-20 73.4 2.1 1.0 1 0 0 1 1 1 1 Ribosomal L28e protein family Lipoxygenase PF00305.19 CDI81732.1 - 0.1 11.0 0.1 0.11 10.9 0.1 1.1 1 0 0 1 1 1 0 Lipoxygenase PfkB PF00294.24 CDI81734.1 - 6.4e-30 104.5 0.2 6e-29 101.3 0.2 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase DUF5520 PF17658.1 CDI81734.1 - 0.03 13.4 2.1 0.044 12.9 2.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5520) SUIM_assoc PF16619.5 CDI81735.1 - 0.017 15.2 7.0 0.017 15.2 7.0 2.8 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 M_domain PF12938.7 CDI81735.1 - 0.64 9.8 23.5 0.61 9.8 9.9 3.0 3 0 0 3 3 3 0 M domain of GW182 Spt20 PF12090.8 CDI81735.1 - 3.9 7.0 13.1 0.2 11.3 7.0 1.8 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI81736.1 - 0.47 10.4 25.9 0.099 12.6 22.6 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Atg14 PF10186.9 CDI81739.1 - 5.8 5.9 8.4 12 4.8 8.4 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DDHD PF02862.17 CDI81740.1 - 5e-05 23.6 5.7 5e-05 23.6 5.7 2.2 2 0 0 2 2 2 1 DDHD domain TT_ORF1 PF02956.14 CDI81740.1 - 0.0011 17.7 3.2 0.0019 17.0 3.2 1.3 1 0 0 1 1 1 1 TT viral orf 1 Tmemb_14 PF03647.13 CDI81740.1 - 0.1 13.4 0.1 1.3 9.8 0.0 2.6 2 0 0 2 2 2 0 Transmembrane proteins 14C MRP-S31 PF15433.6 CDI81740.1 - 0.69 9.5 28.0 0.087 12.5 21.2 2.2 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Otopetrin PF03189.13 CDI81740.1 - 1.2 7.9 3.7 0.29 9.9 0.7 1.7 2 0 0 2 2 2 0 Otopetrin ALMT PF11744.8 CDI81740.1 - 1.5 7.5 19.7 0.13 11.1 14.8 1.6 2 0 0 2 2 2 0 Aluminium activated malate transporter Presenilin PF01080.17 CDI81740.1 - 4.2 6.0 29.4 1.1 7.9 22.7 2.1 2 0 0 2 2 2 0 Presenilin SID-1_RNA_chan PF13965.6 CDI81740.1 - 7.6 4.8 6.5 13 4.1 6.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 zf-CCCH_4 PF18044.1 CDI81741.1 - 0.00012 21.8 2.1 0.0002 21.0 2.1 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 CDI81741.1 - 0.036 14.0 1.3 0.088 12.8 1.3 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) IstB_IS21 PF01695.17 CDI81741.1 - 0.053 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein zf_CCCH_4 PF18345.1 CDI81741.1 - 0.23 11.6 3.2 0.46 10.6 3.2 1.6 1 0 0 1 1 1 0 Zinc finger domain X PF00739.19 CDI81741.1 - 0.79 9.9 9.0 0.42 10.7 2.2 2.7 2 0 0 2 2 2 0 Trans-activation protein X Glt_symporter PF03616.14 CDI81743.1 - 0.0011 17.7 2.2 0.0011 17.7 2.2 3.0 3 1 1 4 4 4 1 Sodium/glutamate symporter SPX PF03105.19 CDI81743.1 - 0.0018 18.2 12.2 0.0018 18.2 12.2 4.0 2 1 0 2 2 2 1 SPX domain TFIIA PF03153.13 CDI81743.1 - 0.0074 16.3 11.3 0.0074 16.3 11.3 4.7 2 1 2 4 4 4 1 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI81743.1 - 0.013 15.5 3.6 0.013 15.5 3.6 9.6 4 2 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Pentapeptide_2 PF01469.18 CDI81743.1 - 0.29 11.0 8.7 0.52 10.2 8.7 1.2 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) PAT1 PF09770.9 CDI81743.1 - 1.2 7.3 67.8 0.42 8.8 45.4 3.4 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 SARAF PF06682.12 CDI81744.1 - 2 8.0 27.7 0.46 10.1 1.5 3.5 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3459 PF11941.8 CDI81744.1 - 3.7 7.9 14.0 0.071 13.4 0.6 4.1 3 2 0 3 3 3 0 Domain of unknown function (DUF3459) Rio2_N PF09202.11 CDI81745.1 - 4.1e-33 113.4 0.8 6.6e-33 112.8 0.8 1.3 1 0 0 1 1 1 1 Rio2, N-terminal RIO1 PF01163.22 CDI81745.1 - 4.4e-19 68.8 0.0 7.1e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 CDI81745.1 - 0.00061 19.2 0.1 0.0012 18.3 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDI81745.1 - 0.0016 18.4 0.1 0.003 17.5 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Replic_Relax PF13814.6 CDI81745.1 - 0.081 13.0 0.8 0.19 11.8 0.8 1.7 1 1 0 1 1 1 0 Replication-relaxation HTH_9 PF08221.11 CDI81745.1 - 0.1 12.7 0.2 0.23 11.6 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Seipin PF06775.14 CDI81746.1 - 0.046 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative adipose-regulatory protein (Seipin) Na_H_Exchanger PF00999.21 CDI81753.1 - 1.6e-15 56.8 4.2 1.6e-15 56.8 4.2 1.6 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family DUF966 PF06136.13 CDI81753.1 - 0.2 11.3 15.9 0.22 11.2 4.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) BAF1_ABF1 PF04684.13 CDI81753.1 - 1.6 7.7 13.1 0.31 10.1 0.7 2.4 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor EIIBC-GUT_N PF03612.14 CDI81761.1 - 0.57 9.9 2.4 1.4 8.6 1.4 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus EPL1 PF10513.9 CDI81761.1 - 7.5 6.9 8.2 2.9 8.2 4.2 2.3 3 0 0 3 3 3 0 Enhancer of polycomb-like Beta-Casp PF10996.8 CDI81773.1 - 1.2e-22 80.3 0.0 2.4e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 CDI81773.1 - 8.2e-08 32.1 0.0 1.8e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain F-box-like PF12937.7 CDI81774.1 - 1.7e-06 27.8 2.0 3.5e-06 26.8 0.0 2.6 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 CDI81774.1 - 0.034 13.7 0.1 0.093 12.3 0.1 1.7 1 0 0 1 1 1 0 F-box F-box PF00646.33 CDI81774.1 - 0.12 12.3 0.0 0.12 12.3 0.0 2.8 3 0 0 3 3 3 0 F-box domain FliG_C PF01706.16 CDI81774.1 - 0.2 11.9 0.0 0.46 10.7 0.0 1.6 1 0 0 1 1 1 0 FliG C-terminal domain Serpin PF00079.20 CDI81782.1 - 4.6e-22 78.8 0.0 5.7e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cpn60_TCP1 PF00118.24 CDI81785.1 - 3e-70 237.3 15.9 2.1e-57 194.9 10.5 2.5 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Fis1_TPR_C PF14853.6 CDI81787.1 - 4.3e-12 45.9 0.1 1e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CDI81787.1 - 0.00023 20.8 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 CDI81787.1 - 0.017 15.2 0.3 0.057 13.5 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDI81787.1 - 0.35 11.6 2.3 0.6 10.9 0.3 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3223 PF11523.8 CDI81788.1 - 0.12 13.2 0.0 0.18 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3223) HEAT PF02985.22 CDI81790.1 - 6 7.4 8.6 68 4.1 0.3 5.6 4 0 0 4 4 4 0 HEAT repeat DNA_pol_E_B PF04042.16 CDI81792.1 - 2.7e-18 66.1 7.3 1.1e-17 64.1 4.3 2.9 2 1 1 3 3 3 1 DNA polymerase alpha/epsilon subunit B Ribosomal_60s PF00428.19 CDI81792.1 - 3.1 8.5 11.4 5.8 7.6 1.4 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein C2 PF00168.30 CDI81794.1 - 4.5e-35 120.0 0.0 2.1e-09 37.6 0.0 6.9 7 0 0 7 7 7 6 C2 domain Ferlin_C PF16165.5 CDI81794.1 - 0.05 13.5 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 Ferlin C-terminus FerI PF08151.12 CDI81794.1 - 0.16 12.1 0.0 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 FerI (NUC094) domain zf-RING_2 PF13639.6 CDI81795.1 - 1.2e-11 44.7 9.2 2e-11 44.1 9.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDI81795.1 - 1.6e-09 37.4 6.2 3.2e-09 36.4 6.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDI81795.1 - 9.2e-08 31.8 8.4 1.4e-07 31.2 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI81795.1 - 2.3e-06 27.4 8.6 4.1e-06 26.5 8.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDI81795.1 - 7.8e-06 26.1 8.9 1.8e-05 24.9 8.9 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDI81795.1 - 3.3e-05 23.9 1.7 6.5e-05 22.9 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CDI81795.1 - 6.3e-05 22.9 5.9 0.00012 22.0 5.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CDI81795.1 - 0.00022 20.8 6.9 0.00036 20.1 6.9 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 CDI81795.1 - 0.00038 20.4 7.1 0.00061 19.7 7.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDI81795.1 - 0.0011 18.8 4.7 0.0016 18.3 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CDI81795.1 - 0.002 17.9 3.1 0.0044 16.8 3.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 CDI81795.1 - 0.0093 16.1 4.3 0.019 15.1 4.3 1.5 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CDI81795.1 - 0.031 14.1 7.0 0.056 13.3 7.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 CDI81795.1 - 0.097 12.8 8.6 0.19 11.9 8.6 1.5 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 CDI81795.1 - 0.37 11.2 7.0 0.66 10.3 7.0 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 CDI81795.1 - 0.66 10.2 7.6 2.5 8.3 7.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Baculo_PEP_C PF04513.12 CDI81797.1 - 0.24 11.4 5.7 1.8 8.6 2.3 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pox_A_type_inc PF04508.12 CDI81797.1 - 0.77 9.7 10.9 1.8 8.5 0.2 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Phosphodiest PF01663.22 CDI81800.1 - 0.00065 19.4 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase LOR PF04525.12 CDI81801.1 - 0.21 11.1 0.1 0.48 10.0 0.1 1.5 1 0 0 1 1 1 0 LURP-one-related PVL_ORF50 PF07768.11 CDI81801.1 - 0.54 10.6 7.6 0.1 12.9 3.4 1.9 2 0 0 2 2 2 0 PVL ORF-50-like family cNMP_binding PF00027.29 CDI81802.1 - 2.1e-78 258.5 2.1 3e-19 68.9 0.0 6.7 6 0 0 6 6 6 5 Cyclic nucleotide-binding domain EF-hand_6 PF13405.6 CDI81802.1 - 0.00073 19.3 0.8 0.67 10.0 0.1 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 CDI81802.1 - 0.00082 18.8 0.2 0.45 10.2 0.1 3.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CDI81802.1 - 0.0012 19.3 4.4 1 9.9 0.0 5.2 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_11 PF08976.11 CDI81802.1 - 0.027 15.3 0.0 0.48 11.3 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain Shugoshin_N PF07558.11 CDI81802.1 - 0.22 11.4 2.8 43 4.1 0.0 4.0 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region RRM_1 PF00076.22 CDI81803.1 - 1.5e-13 50.3 0.0 0.00015 21.5 0.0 4.9 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDI81803.1 - 0.013 15.1 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP21_like_P PF12230.8 CDI81804.1 - 2.6e-43 148.4 5.2 2.6e-43 148.4 5.2 2.0 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 CDI81804.1 - 9.1e-38 128.1 0.9 1.2e-17 63.6 0.0 3.6 4 0 0 4 4 4 2 Surp module DUF1682 PF07946.14 CDI81804.1 - 0.001 18.4 1.8 0.001 18.4 1.8 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1682) ubiquitin PF00240.23 CDI81804.1 - 0.068 12.9 0.3 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin family Peptidase_S9 PF00326.21 CDI81805.1 - 1.1e-33 116.5 0.0 1.1e-33 116.5 0.0 1.9 2 0 0 2 2 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDI81805.1 - 7.4e-07 28.7 3.4 6.2e-05 22.4 0.2 2.7 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Esterase_phd PF10503.9 CDI81805.1 - 0.00013 21.6 0.1 0.00038 20.0 0.1 1.8 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 CDI81805.1 - 0.00019 21.2 8.5 0.0012 18.5 0.8 3.0 2 1 0 3 3 3 2 alpha/beta hydrolase fold COesterase PF00135.28 CDI81805.1 - 0.0015 17.5 0.0 0.0015 17.5 0.0 2.0 2 0 0 2 2 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDI81805.1 - 0.026 14.4 0.1 0.097 12.5 0.1 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold BBS2_C PF14782.6 CDI81805.1 - 1.5 7.5 12.2 2.3 6.9 12.2 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal AF-4 PF05110.13 CDI81805.1 - 1.9 6.4 20.7 2.5 6.1 20.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Otopetrin PF03189.13 CDI81805.1 - 2.7 6.7 6.3 3.6 6.3 6.3 1.1 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 CDI81805.1 - 5.1 6.2 11.1 8.5 5.5 11.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 CDI81805.1 - 7.3 5.3 14.4 9.6 4.9 14.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 CDI81805.1 - 9.1 6.4 10.0 15 5.7 10.0 1.2 1 0 0 1 1 1 0 DDHD domain PapD-like PF14874.6 CDI81806.1 - 4.2e-05 23.6 1.0 0.37 11.0 0.0 3.8 3 0 0 3 3 3 3 Flagellar-associated PapD-like HAGH_C PF16123.5 CDI81806.1 - 9 6.9 8.3 2.2 8.9 2.6 3.1 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus DUF817 PF05675.12 CDI81807.1 - 0.0097 15.6 0.4 0.013 15.2 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF817) HipN PF18253.1 CDI81808.1 - 3.8e-15 55.3 0.0 6.9e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain TPR_1 PF00515.28 CDI81808.1 - 2.9e-11 42.7 4.0 2.4e-08 33.4 0.5 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDI81808.1 - 3.7e-10 40.3 12.3 9.3e-07 29.4 3.8 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDI81808.1 - 1.1e-08 35.1 6.8 3.8e-05 23.7 0.6 2.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI81808.1 - 5.4e-08 32.4 16.8 6.5e-07 29.0 0.6 4.3 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDI81808.1 - 6.1e-07 29.0 2.5 4.8e-05 23.0 0.6 2.6 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 CDI81808.1 - 6.9e-05 23.1 0.5 6.9e-05 23.1 0.5 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat STI1 PF17830.1 CDI81808.1 - 0.00018 21.4 0.3 0.00045 20.1 0.3 1.7 1 0 0 1 1 1 1 STI1 domain TPR_8 PF13181.6 CDI81808.1 - 0.00019 21.4 7.0 0.00071 19.6 0.2 3.3 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI81808.1 - 0.00019 21.9 2.2 0.00072 20.0 2.2 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI81808.1 - 0.00059 20.4 1.0 0.00059 20.4 1.0 3.1 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI81808.1 - 0.0032 17.7 3.6 0.037 14.4 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI81808.1 - 0.073 13.3 0.9 0.16 12.2 0.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 PTPRCAP PF15713.5 CDI81808.1 - 0.24 11.7 16.9 0.036 14.3 3.8 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated KCT2 PF17818.1 CDI81808.1 - 0.33 11.1 1.8 0.67 10.0 1.8 1.4 1 0 0 1 1 1 0 Keratinocyte-associated gene product Velvet PF11754.8 CDI81809.1 - 0.025 14.5 4.8 0.028 14.4 4.8 1.1 1 0 0 1 1 1 0 Velvet factor CLN3 PF02487.17 CDI81809.1 - 0.054 12.5 1.4 0.062 12.3 1.4 1.2 1 0 0 1 1 1 0 CLN3 protein SelP_N PF04592.14 CDI81809.1 - 0.077 12.4 10.0 0.1 12.0 10.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 CDI81809.1 - 0.13 11.0 3.5 0.14 10.9 3.5 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI81809.1 - 0.15 11.8 2.8 0.18 11.5 2.8 1.1 1 0 0 1 1 1 0 Connexin DUF4366 PF14283.6 CDI81809.1 - 0.2 11.7 6.9 0.079 13.0 3.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Miga PF10265.9 CDI81809.1 - 0.25 10.3 5.8 0.3 10.0 5.8 1.0 1 0 0 1 1 1 0 Mitoguardin DUF3405 PF11885.8 CDI81809.1 - 0.28 9.7 6.0 0.35 9.4 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) TFIIA PF03153.13 CDI81809.1 - 0.3 11.0 26.2 0.47 10.4 26.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GET2 PF08690.10 CDI81809.1 - 0.57 9.8 6.8 0.66 9.6 6.8 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Hid1 PF12722.7 CDI81809.1 - 0.74 7.9 4.9 0.87 7.6 4.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RIFIN PF02009.16 CDI81809.1 - 1.4 8.7 10.3 2.2 8.1 10.3 1.3 1 0 0 1 1 1 0 Rifin Neur_chan_memb PF02932.16 CDI81809.1 - 1.7 8.7 4.3 1.9 8.5 4.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 CDI81809.1 - 2.4 6.0 6.6 2.9 5.7 6.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3464 PF11947.8 CDI81809.1 - 2.7 7.7 8.6 14 5.4 8.6 1.9 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 PAT1 PF09770.9 CDI81809.1 - 3 6.0 19.7 3.1 5.9 19.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 IER PF05760.12 CDI81809.1 - 4.1 7.6 17.7 5.2 7.3 17.7 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) Tic110 PF16940.5 CDI81809.1 - 4.6 5.6 24.4 7 5.0 0.3 2.0 2 0 0 2 2 2 0 Chloroplast envelope transporter DUF2892 PF11127.8 CDI81809.1 - 4.9 7.3 0.0 4.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) Pex14_N PF04695.13 CDI81809.1 - 5.1 7.7 23.4 12 6.5 23.4 1.7 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ten_N PF06484.12 CDI81809.1 - 5.5 6.8 9.6 6.3 6.6 9.6 1.0 1 0 0 1 1 1 0 Teneurin Intracellular Region DUF1345 PF07077.11 CDI81809.1 - 6.7 6.4 14.0 16 5.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) Senescence_reg PF04520.13 CDI81809.1 - 6.8 7.5 10.8 3.7 8.3 7.8 1.8 1 1 1 2 2 2 0 Senescence regulator BBS2_N PF14781.6 CDI81809.1 - 7 6.6 8.4 2.3 8.2 1.2 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal DnaJ PF00226.31 CDI81810.1 - 1.7e-14 53.6 0.3 5.1e-14 52.1 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain FAM104 PF15434.6 CDI81810.1 - 0.026 15.1 4.1 0.082 13.5 4.1 1.9 1 0 0 1 1 1 0 Family 104 DUF2250 PF10007.9 CDI81810.1 - 0.059 13.5 3.8 0.13 12.3 2.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) RskA PF10099.9 CDI81811.1 - 1e-05 25.9 8.3 1e-05 25.9 8.3 8.7 3 3 3 6 6 6 2 Anti-sigma-K factor rskA Cytochrom_B_N_2 PF13631.6 CDI81811.1 - 0.0056 16.7 0.1 0.016 15.2 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b(N-terminal)/b6/petB Comm PF15957.5 CDI81811.1 - 0.06 13.7 4.7 12 6.3 0.0 3.7 3 0 0 3 3 3 0 Commissureless DUF4834 PF16118.5 CDI81811.1 - 0.83 10.7 0.0 0.83 10.7 0.0 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF4834) SelP_N PF04592.14 CDI81812.1 - 1.1 8.6 36.4 1.3 8.4 36.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RR_TM4-6 PF06459.12 CDI81812.1 - 2.7 7.7 27.4 3 7.6 27.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 STAC2_u1 PF16664.5 CDI81812.1 - 6.1 7.3 22.0 9.5 6.7 22.0 1.3 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 DUF1645 PF07816.11 CDI81813.1 - 0.004 17.8 4.1 0.004 17.8 4.1 9.8 5 3 2 7 7 7 1 Protein of unknown function (DUF1645) DUF4667 PF15700.5 CDI81813.1 - 0.0085 16.2 3.4 0.0085 16.2 3.4 9.1 5 3 2 8 8 8 1 Domain of unknown function (DUF4667) Connexin PF00029.19 CDI81814.1 - 0.013 15.3 1.2 0.064 13.0 0.5 2.3 2 0 0 2 2 2 0 Connexin LMBR1 PF04791.16 CDI81814.1 - 0.12 11.3 2.7 0.25 10.2 2.7 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Rgp1 PF08737.10 CDI81814.1 - 0.45 9.6 13.7 0.84 8.7 5.3 2.8 3 0 0 3 3 3 0 Rgp1 PIP5K PF01504.18 CDI81814.1 - 0.98 8.6 11.5 1.6 7.8 2.2 2.7 2 1 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Paramyxo_ncap PF00973.19 CDI81814.1 - 1.1 8.1 8.6 2.6 6.9 8.6 1.5 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4770 PF15994.5 CDI81814.1 - 1.8 8.8 15.2 0.1 12.8 3.3 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4770) Sarcoglycan_2 PF05510.13 CDI81814.1 - 3.1 6.5 7.4 11 4.7 2.5 2.6 2 1 0 2 2 2 0 Sarcoglycan alpha/epsilon DUF2052 PF09747.9 CDI81814.1 - 3.1 7.9 23.5 0.81 9.8 12.8 2.9 3 1 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) DUF2244 PF10003.9 CDI81814.1 - 3.4 7.3 6.6 0.66 9.6 0.5 2.5 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Otopetrin PF03189.13 CDI81814.1 - 3.8 6.2 6.7 10 4.8 6.7 1.8 1 1 0 1 1 1 0 Otopetrin 60KD_IMP PF02096.20 CDI81814.1 - 4.2 7.3 12.0 0.084 12.8 3.8 2.2 3 0 0 3 3 3 0 60Kd inner membrane protein Rxt3 PF08642.10 CDI81814.1 - 5.2 7.9 8.7 4.9 7.9 2.8 3.3 4 0 0 4 4 3 0 Histone deacetylation protein Rxt3 DRY_EERY PF09750.9 CDI81814.1 - 9.7 6.5 17.0 2.6 8.3 9.8 2.9 3 0 0 3 3 3 0 Alternative splicing regulator SHNi-TPR PF10516.9 CDI81815.1 - 0.00029 20.2 0.0 0.001 18.5 0.0 1.9 1 0 0 1 1 1 1 SHNi-TPR SUIM_assoc PF16619.5 CDI81815.1 - 0.003 17.6 2.9 0.003 17.6 2.9 8.3 6 3 0 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 TPR_2 PF07719.17 CDI81815.1 - 0.0032 17.5 0.7 0.4 10.9 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat RskA PF10099.9 CDI81815.1 - 0.0057 17.0 17.1 0.0057 17.0 17.1 6.6 2 1 4 6 6 6 1 Anti-sigma-K factor rskA TPR_1 PF00515.28 CDI81815.1 - 0.013 15.3 1.3 0.34 10.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat AMPK1_CBM PF16561.5 CDI81816.1 - 2.3e-12 47.0 0.0 7e-12 45.4 0.0 1.8 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase IQ PF00612.27 CDI81816.1 - 2.1e-09 36.3 28.2 0.002 17.7 0.9 5.1 5 0 0 5 5 5 4 IQ calmodulin-binding motif Tubulin PF00091.25 CDI81818.1 - 6.9e-67 225.5 0.0 9.6e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDI81818.1 - 6e-51 171.9 0.3 1.6e-50 170.5 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDI81818.1 - 0.033 13.9 0.0 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 Tubulin domain Ribosomal_L27A PF00828.19 CDI81819.1 - 1.6e-09 38.5 0.1 1.8e-08 35.1 0.0 2.7 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF1664 PF07889.12 CDI81819.1 - 0.011 15.8 0.7 0.024 14.7 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FemAB PF02388.16 CDI81819.1 - 0.05 12.5 1.0 0.078 11.8 1.0 1.2 1 0 0 1 1 1 0 FemAB family PIEZO PF15917.5 CDI81819.1 - 0.09 12.2 4.6 0.15 11.5 4.6 1.3 1 0 0 1 1 1 0 Piezo Cob_adeno_trans PF01923.18 CDI81819.1 - 0.33 11.1 3.5 0.8 9.8 3.5 1.8 1 1 0 1 1 1 0 Cobalamin adenosyltransferase TFIIA PF03153.13 CDI81819.1 - 2.1 8.3 18.6 2.6 7.9 18.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop25 PF09805.9 CDI81819.1 - 2.4 8.6 7.7 4.6 7.7 7.7 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TrmO_C PF18389.1 CDI81821.1 - 0.074 13.2 0.2 15 5.8 0.1 2.5 2 0 0 2 2 2 0 TrmO C-terminal domain DUF4677 PF15726.5 CDI81821.1 - 0.16 12.1 4.4 8.2 6.5 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) Phage_holin_2_2 PF10746.9 CDI81821.1 - 0.23 11.1 0.0 32 4.3 0.0 2.5 2 0 0 2 2 2 0 Phage holin T7 family, holin superfamily II BHD_2 PF10404.9 CDI81821.1 - 2.3 9.3 5.1 27 5.8 0.1 2.9 3 1 0 3 3 3 0 Rad4 beta-hairpin domain 2 Col_cuticle_N PF01484.17 CDI81821.1 - 3.3 7.9 4.9 6.8 6.8 4.9 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Activator_LAG-3 PF11498.8 CDI81823.1 - 0.0013 17.8 23.8 0.0013 17.8 23.8 3.3 3 0 0 3 3 3 3 Transcriptional activator LAG-3 eIF3_subunit PF08597.10 CDI81827.1 - 4e-24 85.8 15.7 4.6e-24 85.7 15.7 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit MutS_III PF05192.18 CDI81827.1 - 0.043 14.0 0.1 0.043 14.0 0.1 2.0 1 1 0 2 2 2 0 MutS domain III TFIIA PF03153.13 CDI81830.1 - 0.00046 20.3 22.8 0.00046 20.3 22.8 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 CDI81830.1 - 0.43 8.8 18.8 0.59 8.3 18.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 CDI81830.1 - 0.51 9.3 4.5 1.2 8.1 4.5 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 CDI81830.1 - 2.4 7.9 23.5 0.056 13.3 16.6 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CDI81830.1 - 3.9 6.4 16.7 5.7 5.8 16.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Macoilin PF09726.9 CDI81830.1 - 6 5.3 18.2 8.9 4.7 18.2 1.1 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 CDI81830.1 - 6.1 6.3 28.9 0.24 10.9 22.6 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist SAPS PF04499.15 CDI81830.1 - 8.1 5.1 12.7 12 4.5 12.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF523 PF04463.12 CDI81832.1 - 0.012 15.6 0.0 0.045 13.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF523) Chromo PF00385.24 CDI81833.1 - 1.2e-15 57.1 0.0 1.9e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain FAT PF02259.23 CDI81834.1 - 7.3e-20 71.5 6.1 2.1e-19 69.9 6.1 1.8 1 1 0 1 1 1 1 FAT domain Spt20 PF12090.8 CDI81834.1 - 0.0034 17.0 17.2 0.0034 17.0 17.2 1.5 2 0 0 2 2 1 1 Spt20 family GREB1 PF15782.5 CDI81834.1 - 0.0074 13.5 5.5 0.0086 13.3 5.5 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer MPM1 PF17234.2 CDI81834.1 - 0.0086 16.3 3.0 0.014 15.7 3.0 1.3 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 SARAF PF06682.12 CDI81834.1 - 0.014 15.0 1.4 0.02 14.6 1.4 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF1645 PF07816.11 CDI81834.1 - 0.017 15.7 5.0 0.032 14.8 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Cwf_Cwc_15 PF04889.12 CDI81834.1 - 0.018 14.8 4.7 0.028 14.2 4.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Menin PF05053.13 CDI81834.1 - 0.038 12.3 3.0 0.064 11.6 3.0 1.3 1 0 0 1 1 1 0 Menin DUF755 PF05501.11 CDI81834.1 - 0.042 14.1 21.1 0.12 12.7 21.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF4718 PF15842.5 CDI81834.1 - 0.053 13.3 7.1 0.095 12.5 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF702 PF05142.12 CDI81834.1 - 0.084 13.3 6.7 0.19 12.2 6.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF702) AF-4 PF05110.13 CDI81834.1 - 0.21 9.6 15.9 0.3 9.1 15.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM76 PF16046.5 CDI81834.1 - 0.25 10.7 7.5 0.44 9.9 7.5 1.3 1 0 0 1 1 1 0 FAM76 protein CPSF100_C PF13299.6 CDI81834.1 - 0.36 11.0 2.0 0.62 10.2 2.0 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SPX PF03105.19 CDI81834.1 - 0.36 10.7 9.9 0.59 10.0 9.9 1.2 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 CDI81834.1 - 1.6 8.2 13.9 2.8 7.4 13.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Gti1_Pac2 PF09729.9 CDI81834.1 - 1.6 8.8 6.8 2.7 8.1 6.8 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family RAP1 PF07218.11 CDI81834.1 - 2.2 6.4 5.1 3 6.0 5.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Miga PF10265.9 CDI81834.1 - 4.4 6.2 8.2 6.4 5.6 8.2 1.1 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 CDI81834.1 - 5.2 5.7 11.8 7.8 5.1 11.8 1.1 1 0 0 1 1 1 0 Presenilin Plasmodium_Vir PF05795.11 CDI81834.1 - 5.4 6.3 6.0 8 5.8 6.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Macoilin PF09726.9 CDI81834.1 - 6.9 5.1 13.3 10 4.5 13.3 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI81834.1 - 7.8 6.4 29.7 13 5.6 29.7 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDK2AP PF09806.9 CDI81834.1 - 7.9 6.5 16.8 15 5.6 16.8 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein SR-25 PF10500.9 CDI81834.1 - 8.1 6.0 19.0 14 5.2 19.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ALMT PF11744.8 CDI81834.1 - 8.9 5.0 9.1 14 4.4 9.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Aminotran_1_2 PF00155.21 CDI81837.1 - 1.8e-22 80.1 0.0 3.7e-14 52.7 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class I and II Kdo PF06293.14 CDI81838.1 - 3.4e-05 23.3 0.2 0.064 12.6 0.0 2.9 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CDI81838.1 - 0.068 12.5 0.0 2.4 7.5 0.0 2.3 2 1 0 2 2 2 0 Protein kinase domain RIO1 PF01163.22 CDI81838.1 - 0.091 12.4 0.1 7.6 6.1 0.0 2.8 3 0 0 3 3 3 0 RIO1 family APH PF01636.23 CDI81838.1 - 0.19 11.6 2.0 14 5.5 0.0 3.2 3 1 0 3 3 3 0 Phosphotransferase enzyme family Med3 PF11593.8 CDI81838.1 - 1.8 7.7 14.1 4.3 6.4 14.1 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TauE PF01925.19 CDI81841.1 - 2.3e-07 30.7 5.1 2.3e-07 30.7 5.1 3.4 3 1 0 3 3 3 1 Sulfite exporter TauE/SafE DUF2294 PF10057.9 CDI81843.1 - 2.2e-06 27.7 46.1 0.25 11.5 3.6 8.0 1 1 8 9 9 9 8 Uncharacterized conserved protein (DUF2294) VPS13_C PF16909.5 CDI81844.1 - 8.9e-08 32.1 0.0 8.9e-08 32.1 0.0 2.5 2 1 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal RskA PF10099.9 CDI81844.1 - 0.66 10.2 0.0 0.66 10.2 0.0 7.8 4 1 4 8 8 8 0 Anti-sigma-K factor rskA Utp14 PF04615.13 CDI81844.1 - 0.69 8.4 31.4 1.2 7.6 31.4 1.3 1 0 0 1 1 1 0 Utp14 protein SAPS PF04499.15 CDI81844.1 - 3.3 6.4 19.5 6.6 5.4 19.5 1.5 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ESM4 PF15952.5 CDI81844.1 - 8.9 6.7 43.0 14 6.1 9.0 3.5 3 0 0 3 3 3 0 Enhancer of split M4 family SUIM_assoc PF16619.5 CDI81847.1 - 2.5e-05 24.2 3.2 3.9 7.6 0.0 3.6 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 PRP3 PF08572.10 CDI81847.1 - 0.00027 20.8 22.3 0.00056 19.7 2.0 4.4 4 1 1 5 5 5 3 pre-mRNA processing factor 3 (PRP3) Draxin PF15550.6 CDI81847.1 - 4.3 7.1 12.2 7.9 6.3 5.4 2.1 2 0 0 2 2 2 0 Draxin DUF4461 PF14688.6 CDI81847.1 - 6.8 6.4 9.7 23 4.6 9.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4461) Sin_N PF04801.13 CDI81849.1 - 0.0021 17.3 11.7 0.0021 17.3 11.7 2.1 2 0 0 2 2 2 2 Sin-like protein conserved region PTPRCAP PF15713.5 CDI81849.1 - 0.011 16.0 8.1 0.011 16.0 8.1 2.6 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated FAM176 PF14851.6 CDI81849.1 - 0.46 10.1 3.7 0.37 10.4 0.2 2.3 2 0 0 2 2 2 0 FAM176 family Arb1 PF09692.10 CDI81849.1 - 0.8 8.8 9.4 0.24 10.5 1.0 2.3 2 0 0 2 2 2 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 DUF4746 PF15928.5 CDI81849.1 - 1.1 8.6 8.3 0.034 13.6 1.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) MMADHC PF10229.9 CDI81849.1 - 1.5 8.5 10.5 2.8 7.6 2.6 2.2 2 0 0 2 2 2 0 Methylmalonic aciduria and homocystinuria type D protein PIP5K PF01504.18 CDI81849.1 - 2.2 7.4 5.8 1.7 7.8 2.1 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase SPX PF03105.19 CDI81849.1 - 7.3 6.4 14.3 0.33 10.8 5.8 2.2 2 0 0 2 2 2 0 SPX domain Lin-8 PF03353.15 CDI81849.1 - 7.4 6.0 30.9 1 8.8 10.5 2.4 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist XRN_N PF03159.18 CDI81850.1 - 1e-76 257.6 0.2 1.2e-76 257.4 0.2 1.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus MAM33 PF02330.16 CDI81850.1 - 0.0017 18.3 0.8 0.0033 17.4 0.8 1.4 1 0 0 1 1 1 1 Mitochondrial glycoprotein DUF2722 PF10846.8 CDI81850.1 - 0.0065 15.5 2.5 0.0073 15.3 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) CobT PF06213.12 CDI81850.1 - 3.3 7.0 10.1 5.4 6.3 10.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SPAN PF02510.14 CDI81850.1 - 4.4 6.4 10.1 6.8 5.8 10.1 1.2 1 0 0 1 1 1 0 Surface presentation of antigens protein DUF3729 PF12526.8 CDI81852.1 - 0.032 15.8 10.6 0.032 15.8 10.6 10.7 3 2 7 11 11 11 0 Protein of unknown function (DUF3729) DUF5403 PF17395.2 CDI81852.1 - 0.45 10.8 4.0 0.56 10.5 0.9 2.9 1 1 1 2 2 2 0 Family of unknown function (DUF5403) Ank_4 PF13637.6 CDI81853.1 - 2.2e-21 76.0 3.0 8.2e-10 39.0 0.0 4.2 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI81853.1 - 2.2e-21 76.2 3.4 6.2e-10 39.5 0.1 3.1 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI81853.1 - 1.8e-18 64.7 3.4 6.4e-06 26.1 0.1 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 CDI81853.1 - 2.9e-16 59.3 6.4 0.00018 21.7 0.0 4.8 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 CDI81853.1 - 1.1e-15 57.3 9.6 4.7e-05 23.6 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Alkyl_sulf_C PF14864.6 CDI81854.1 - 4.3e-07 30.3 0.1 0.0037 17.5 0.0 3.1 2 0 0 2 2 2 2 Alkyl sulfatase C-terminal Lactamase_B PF00753.27 CDI81854.1 - 2.8e-05 24.2 0.0 0.0035 17.4 0.0 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Neur_chan_memb PF02932.16 CDI81854.1 - 0.0018 18.3 15.3 0.0018 18.3 15.3 3.6 2 2 2 4 4 4 1 Neurotransmitter-gated ion-channel transmembrane region DUF5523 PF17661.1 CDI81854.1 - 0.0036 17.0 14.9 0.0036 17.0 14.9 4.3 4 1 0 4 4 3 1 Family of unknown function (DUF5523) Pex14_N PF04695.13 CDI81854.1 - 0.0053 17.4 17.7 0.0053 17.4 17.7 5.0 4 1 0 4 4 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI81854.1 - 0.01 14.7 62.0 0.02 13.7 23.8 3.3 3 1 0 3 3 3 0 Presenilin RP-C_C PF11800.8 CDI81854.1 - 0.012 15.7 11.9 0.012 15.7 11.9 3.9 4 1 0 4 4 3 0 Replication protein C C-terminal region SUIM_assoc PF16619.5 CDI81854.1 - 0.076 13.1 0.1 0.076 13.1 0.1 10.9 4 2 4 8 8 2 0 Unstructured region C-term to UIM in Ataxin3 Phostensin_N PF13916.6 CDI81854.1 - 0.12 12.7 0.1 0.12 12.7 0.1 8.8 4 2 0 5 5 2 0 PP1-regulatory protein, Phostensin N-terminal CDC45 PF02724.14 CDI81854.1 - 0.17 10.1 52.5 0.022 13.1 19.1 2.9 3 0 0 3 3 3 0 CDC45-like protein RR_TM4-6 PF06459.12 CDI81854.1 - 1 9.2 60.6 0.081 12.7 20.1 3.4 4 0 0 4 4 4 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.9 CDI81854.1 - 1 8.1 42.1 0.31 9.8 0.4 3.5 4 0 0 4 4 4 0 Golgi-body localisation protein domain Endostatin PF06482.11 CDI81854.1 - 1.5 8.2 46.0 0.71 9.3 14.4 3.7 4 0 0 4 4 4 0 Collagenase NC10 and Endostatin Peroxin-3 PF04882.12 CDI81854.1 - 6.1 5.7 48.9 0.32 10.0 14.0 3.3 3 1 0 3 3 3 0 Peroxin-3 ASD2 PF08687.11 CDI81854.1 - 7.4 6.0 63.6 1.8 8.0 20.1 4.0 4 0 0 4 4 4 0 Apx/Shroom domain ASD2 CAF1C_H4-bd PF12265.8 CDI81855.1 - 7.8e-14 51.7 0.0 1.5e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDI81855.1 - 6.5e-05 23.6 3.1 0.11 13.5 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI81855.1 - 0.038 14.3 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain BURP PF03181.15 CDI81855.1 - 0.065 12.8 0.3 0.13 11.9 0.3 1.4 1 0 0 1 1 1 0 BURP domain IMUP PF15761.5 CDI81855.1 - 5.2 7.8 29.3 0.78 10.5 10.8 4.3 4 0 0 4 4 4 0 Immortalisation up-regulated protein RAP1 PF07218.11 CDI81855.1 - 5.9 5.0 11.0 12 4.1 11.0 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) KBP_C PF12309.8 CDI81856.1 - 6e-21 75.4 0.3 6e-21 75.4 0.3 6.1 5 2 0 5 5 5 1 KIF-1 binding protein C terminal Spt20 PF12090.8 CDI81856.1 - 0.00048 19.8 11.1 0.00048 19.8 11.1 9.0 6 3 2 8 8 8 1 Spt20 family DUF2722 PF10846.8 CDI81857.1 - 0.0017 17.4 13.9 0.0017 17.4 13.9 3.0 4 0 0 4 4 4 1 Protein of unknown function (DUF2722) DUF3854 PF12965.7 CDI81857.1 - 0.066 13.2 3.3 4.3 7.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3854) SR-25 PF10500.9 CDI81857.1 - 0.39 10.3 42.8 0.75 9.4 20.2 3.4 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein SieB PF14163.6 CDI81857.1 - 2.2 7.8 8.1 1.3 8.5 0.8 2.3 2 0 0 2 2 2 0 Super-infection exclusion protein B CDC37_N PF03234.14 CDI81857.1 - 2.4 9.1 18.1 2.5 9.0 7.8 2.6 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Piezo_RRas_bdg PF12166.8 CDI81857.1 - 4.4 6.5 11.6 5.7 6.1 11.6 1.2 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DivIC PF04977.15 CDI81857.1 - 6 6.7 27.3 0.63 9.9 14.2 2.5 2 0 0 2 2 2 0 Septum formation initiator DUF2973 PF11189.8 CDI81857.1 - 9.7 6.4 7.5 6.7 6.9 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) TPR_2 PF07719.17 CDI81858.1 - 0.72 10.1 19.3 2.9 8.2 0.2 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDI81858.1 - 8 6.5 19.6 1.9 8.5 0.8 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Phage_TAC_7 PF10109.9 CDI81859.1 - 0.017 15.2 0.1 0.041 14.0 0.1 1.7 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, E, or 41 or 14 DUF3334 PF11813.8 CDI81859.1 - 0.051 13.3 0.1 0.079 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3334) Myb_DNA-bind_6 PF13921.6 CDI81859.1 - 0.087 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF1180 PF06679.12 CDI81860.1 - 0.0033 17.9 1.8 0.0033 17.9 1.8 3.6 2 1 2 4 4 4 1 Protein of unknown function (DUF1180) SUIM_assoc PF16619.5 CDI81860.1 - 0.016 15.2 9.3 0.037 14.1 3.7 3.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 PepSY_TM_like_2 PF16357.5 CDI81860.1 - 0.19 11.7 0.5 0.4 10.6 0.5 1.5 1 0 0 1 1 1 0 Putative PepSY_TM-like LytR_C PF13399.6 CDI81860.1 - 2.4 9.2 7.9 0.46 11.5 2.0 2.6 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator Pkinase PF00069.25 CDI81862.1 - 6.7e-53 179.7 0.0 6.7e-53 179.7 0.0 2.4 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI81862.1 - 4e-21 75.5 0.0 1.6e-20 73.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CDI81862.1 - 0.13 12.2 0.0 0.13 12.2 0.0 4.5 3 1 1 4 4 4 0 Phosphotransferase enzyme family Defensin_RK-1 PF17860.1 CDI81863.1 - 0.059 13.8 0.1 0.16 12.5 0.1 1.8 1 0 0 1 1 1 0 RK-1-like defensin Pre-SET PF05033.16 CDI81864.1 - 2.1e-06 28.4 0.6 1e-05 26.2 0.0 1.9 2 0 0 2 2 2 1 Pre-SET motif SAD_SRA PF02182.17 CDI81865.1 - 1e-08 35.0 0.3 1e-08 35.0 0.3 2.5 2 0 0 2 2 2 1 SAD/SRA domain Dehydrin PF00257.19 CDI81865.1 - 0.0089 16.6 7.1 0.0089 16.6 7.1 5.6 4 2 1 5 5 5 2 Dehydrin DUF2554 PF10829.8 CDI81866.1 - 0.15 12.5 0.9 0.46 10.9 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2554) DAG_kinase_N PF14513.6 CDI81867.1 - 0.026 14.7 0.0 0.027 14.7 0.0 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus EF-hand_6 PF13405.6 CDI81867.1 - 0.037 14.0 0.2 0.16 12.0 0.1 2.2 2 1 0 2 2 2 0 EF-hand domain DUF3381 PF11861.8 CDI81869.1 - 3e-39 134.5 18.0 3e-39 134.5 18.0 5.3 4 1 1 5 5 5 1 Domain of unknown function (DUF3381) FtsJ PF01728.19 CDI81869.1 - 2.6e-08 34.2 0.0 6.5e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase Androgen_recep PF02166.16 CDI81869.1 - 0.046 12.6 43.2 0.015 14.2 19.8 2.4 2 0 0 2 2 2 0 Androgen receptor ASFV_J13L PF05568.11 CDI81869.1 - 1.3 8.8 7.3 2.9 7.6 1.2 2.5 2 0 0 2 2 2 0 African swine fever virus J13L protein CRT10 PF08728.10 CDI81871.1 - 0.68 8.0 3.7 0.8 7.8 3.7 1.1 1 0 0 1 1 1 0 CRT10 Form_Nir_trans PF01226.17 CDI81876.1 - 2.6e-06 26.9 0.8 4.1e-06 26.3 0.8 1.3 1 0 0 1 1 1 1 Formate/nitrite transporter HEAT_EZ PF13513.6 CDI81877.1 - 5.9e-07 29.9 3.5 0.73 10.4 0.0 3.6 2 1 0 3 3 3 3 HEAT-like repeat HEAT PF02985.22 CDI81877.1 - 6.8e-06 25.9 8.5 0.0019 18.3 0.5 4.1 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 CDI81877.1 - 0.0026 17.8 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 CDI81877.1 - 0.066 13.3 2.4 0.23 11.5 0.0 2.6 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat CENP-F_leu_zip PF10473.9 CDI81880.1 - 0.1 12.6 14.2 0.029 14.4 5.5 2.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BBS2_C PF14782.6 CDI81880.1 - 6 5.5 7.9 18 3.9 7.9 1.8 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal PARP PF00644.20 CDI81883.1 - 3.1e-51 173.8 0.0 5.8e-51 172.9 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 CDI81883.1 - 1.3e-29 103.0 0.9 2.9e-29 101.9 0.9 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain BRCT PF00533.26 CDI81883.1 - 5.1e-09 36.4 0.0 1.3e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain WGR PF05406.15 CDI81883.1 - 1.3e-08 34.7 0.8 4.1e-08 33.2 0.4 2.1 2 0 0 2 2 2 1 WGR domain zf-PARP PF00645.18 CDI81883.1 - 2.8e-05 24.9 0.1 0.00012 22.9 0.0 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PADR1 PF08063.12 CDI81883.1 - 7.2e-05 22.5 0.1 0.0002 21.0 0.1 1.8 1 0 0 1 1 1 1 PADR1 (NUC008) domain PTCB-BRCT PF12738.7 CDI81883.1 - 0.0038 17.1 0.0 0.0095 15.9 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CDI81883.1 - 0.067 13.6 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Ribosomal_L27e PF01777.18 CDI81884.1 - 3.4e-25 88.2 3.7 4.3e-25 87.9 3.7 1.1 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 CDI81884.1 - 0.00055 19.8 0.7 0.001 18.9 0.7 1.4 1 0 0 1 1 1 1 KOW motif rRNA_proc-arch PF13234.6 CDI81884.1 - 0.02 14.8 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 rRNA-processing arch domain Nitrate_red_gam PF02665.14 CDI81887.1 - 0.3 10.6 0.1 0.48 9.9 0.1 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit VPDSG-CTERM PF18205.1 CDI81887.1 - 1.4 8.8 3.8 3.1 7.7 3.8 1.6 1 0 0 1 1 1 0 VPDSG-CTERM motif VirB3 PF05101.13 CDI81888.1 - 7.8 6.8 8.8 0.31 11.3 0.9 2.2 3 0 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein Phage_int_SAM_6 PF18644.1 CDI81889.1 - 0.23 11.5 2.9 0.45 10.5 2.3 1.8 1 1 1 2 2 2 0 Phage integrase SAM-like domain Exonuc_VII_L PF02601.15 CDI81889.1 - 0.56 9.7 6.5 1 8.8 6.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit RskA PF10099.9 CDI81890.1 - 0.0046 17.3 10.8 0.0046 17.3 10.8 5.1 3 2 0 3 3 3 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI81890.1 - 0.0089 16.1 0.1 0.0089 16.1 0.1 7.2 4 2 2 6 6 6 1 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 CDI81890.1 - 0.039 14.6 0.7 0.039 14.6 0.7 4.7 3 2 2 5 5 5 0 60s Acidic ribosomal protein CNDH2_C PF16858.5 CDI81890.1 - 0.6 9.9 26.4 0.041 13.8 3.3 3.0 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Presenilin PF01080.17 CDI81890.1 - 4.6 5.9 40.7 0.11 11.3 7.9 3.0 3 0 0 3 3 3 0 Presenilin Cep57_CLD_2 PF14197.6 CDI81892.1 - 0.099 12.7 6.6 0.6 10.2 4.7 2.6 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 FAM184 PF15665.5 CDI81892.1 - 0.14 11.9 12.8 0.44 10.3 12.8 1.8 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B FlgN PF05130.12 CDI81892.1 - 0.19 12.2 13.8 0.093 13.2 10.1 2.1 1 1 1 2 2 2 0 FlgN protein Occludin_ELL PF07303.13 CDI81892.1 - 0.19 12.5 3.9 3.3 8.5 2.7 2.5 1 1 1 2 2 2 0 Occludin homology domain OmpH PF03938.14 CDI81892.1 - 0.39 11.1 20.2 0.033 14.5 12.6 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) bZIP_2 PF07716.15 CDI81892.1 - 0.44 10.7 8.3 0.24 11.5 2.7 3.0 3 0 0 3 3 3 0 Basic region leucine zipper TFA2_Winged_2 PF18121.1 CDI81892.1 - 0.59 9.9 2.5 5.1 6.9 0.3 3.1 3 1 1 4 4 4 0 TFA2 Winged helix domain 2 DUF4110 PF13422.6 CDI81892.1 - 0.77 9.9 8.4 0.15 12.1 1.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4110) DUF4407 PF14362.6 CDI81892.1 - 0.93 8.8 16.7 4 6.7 16.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Muted PF14942.6 CDI81892.1 - 1.2 9.5 9.0 0.2 12.0 3.5 2.0 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF1640 PF07798.11 CDI81892.1 - 1.6 8.8 10.5 0.74 9.8 6.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) M PF02370.16 CDI81892.1 - 6.9 7.6 16.6 11 7.0 7.3 4.1 4 0 0 4 4 3 0 M protein repeat TMPIT PF07851.13 CDI81892.1 - 7.9 5.6 9.2 18 4.5 4.2 2.0 1 1 2 3 3 3 0 TMPIT-like protein TMF_TATA_bd PF12325.8 CDI81892.1 - 8 6.7 14.9 1 9.6 8.5 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding RskA PF10099.9 CDI81895.1 - 4.6e-06 27.0 1.3 4.6e-06 27.0 1.3 4.5 1 1 2 3 3 3 1 Anti-sigma-K factor rskA vATP-synt_E PF01991.18 CDI81895.1 - 0.014 14.8 2.1 0.014 14.8 2.1 3.2 2 1 1 3 3 3 0 ATP synthase (E/31 kDa) subunit TMEM144 PF07857.12 CDI81895.1 - 8 5.3 8.5 2.8 6.8 0.1 3.0 3 0 0 3 3 3 0 Transmembrane family, TMEM144 of transporters PIP5K PF01504.18 CDI81897.1 - 3.5e-26 92.1 36.0 2e-22 79.7 11.3 4.1 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase TFIIA PF03153.13 CDI81897.1 - 0.00042 20.4 25.3 0.00042 20.4 25.3 2.9 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit PI3_PI4_kinase PF00454.27 CDI81897.1 - 0.27 11.0 3.7 0.52 10.1 3.7 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase CNDH2_C PF16858.5 CDI81897.1 - 0.32 10.8 23.4 0.011 15.7 8.2 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 CDI81897.1 - 5.3 5.2 26.7 0.11 10.8 9.0 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF4064 PF13273.6 CDI81900.1 - 0.052 13.8 0.7 0.052 13.8 0.7 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF4064) Peptidase_U4 PF03419.13 CDI81900.1 - 9.1 5.5 13.4 20 4.4 13.4 1.6 1 1 0 1 1 1 0 Sporulation factor SpoIIGA UQ_con PF00179.26 CDI81901.1 - 2e-36 124.7 0.0 2.5e-36 124.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CDI81901.1 - 0.008 16.0 0.1 0.016 15.1 0.1 1.5 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 CDI81901.1 - 0.0083 15.8 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDI81901.1 - 0.12 12.6 0.4 0.18 12.1 0.2 1.4 1 1 0 1 1 1 0 RWD domain RskA PF10099.9 CDI81902.1 - 4.7e-05 23.8 37.3 0.024 14.9 0.0 4.2 2 2 2 4 4 4 2 Anti-sigma-K factor rskA PhoLip_ATPase_C PF16212.5 CDI81902.1 - 0.0011 18.8 0.4 0.0016 18.2 0.4 1.2 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal DUF3446 PF11928.8 CDI81902.1 - 0.019 15.3 1.4 0.019 15.3 1.4 5.8 3 1 2 5 5 5 0 Early growth response N-terminal domain DUF4761 PF15958.5 CDI81902.1 - 0.38 10.9 1.8 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4761) Sprouty PF05210.13 CDI81902.1 - 0.39 11.1 3.9 0.24 11.8 1.3 2.0 1 1 0 2 2 2 0 Sprouty protein (Spry) DUF4171 PF13775.6 CDI81902.1 - 3.5 8.1 24.0 0.17 12.4 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) SPX PF03105.19 CDI81902.1 - 5.4 6.8 17.9 19 5.1 18.0 1.7 1 1 0 1 1 1 0 SPX domain UvrD_C PF13361.6 CDI81903.1 - 1 8.6 9.5 0.37 10.1 5.8 2.1 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain TnpV PF14198.6 CDI81903.1 - 7.2 6.6 11.5 0.63 10.0 1.4 4.2 3 0 0 3 3 3 0 Transposon-encoded protein TnpV Myosin_head PF00063.21 CDI81904.1 - 1.9e-161 538.7 0.3 2.5e-161 538.3 0.3 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MFS_1 PF07690.16 CDI81906.1 - 0.016 14.2 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily PPP4R2 PF09184.11 CDI81906.1 - 1.6 8.3 28.7 0.16 11.5 23.3 1.8 2 0 0 2 2 2 0 PPP4R2 DUF966 PF06136.13 CDI81906.1 - 6.8 6.3 34.5 11 5.6 29.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Sugar_tr PF00083.24 CDI81906.1 - 9.6 4.9 13.4 0.068 12.0 0.2 2.9 2 2 1 3 3 3 0 Sugar (and other) transporter RRM_1 PF00076.22 CDI81907.1 - 2.3e-19 69.0 0.0 4.9e-18 64.7 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 CDI81907.1 - 1.3e-11 44.3 1.6 3.3e-11 43.1 1.6 1.7 1 0 0 1 1 1 1 WW domain RNA_bind PF08675.11 CDI81907.1 - 0.0089 16.0 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain Nup35_RRM PF05172.13 CDI81907.1 - 0.023 14.7 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PP-binding PF00550.25 CDI81908.1 - 2.6e-15 56.5 0.1 3.5e-15 56.1 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CDI81908.1 - 2.1e-05 24.7 0.3 3e-05 24.1 0.3 1.4 1 0 0 1 1 1 1 Acyl-carrier Ribosomal_L50 PF10501.9 CDI81908.1 - 0.0045 17.1 0.0 0.0061 16.7 0.0 1.4 1 1 0 1 1 1 1 Ribosomal subunit 39S Ribosomal_L12_N PF16320.5 CDI81908.1 - 0.047 13.4 0.1 0.047 13.4 0.1 3.4 3 1 0 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain TPR_14 PF13428.6 CDI81909.1 - 0.087 13.7 0.2 0.12 13.2 0.2 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat CTP_transf_like PF01467.26 CDI81910.1 - 1.9e-18 67.0 0.0 6.8e-18 65.2 0.0 2.0 2 0 0 2 2 2 1 Cytidylyltransferase-like Retrotran_gag_3 PF14244.6 CDI81910.1 - 0.17 11.7 0.1 0.43 10.4 0.1 1.7 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type TFIIA PF03153.13 CDI81910.1 - 0.89 9.5 30.5 1.4 8.8 11.2 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Beta-Casp PF10996.8 CDI81912.1 - 3.5e-05 24.0 0.0 0.00045 20.5 0.0 2.8 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 CDI81912.1 - 0.047 13.1 0.1 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain DUF1840 PF08895.11 CDI81912.1 - 0.14 12.5 1.2 2 8.8 0.0 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) PI3_PI4_kinase PF00454.27 CDI81913.1 - 2.4e-24 86.5 2.0 4.5e-22 79.1 0.0 3.0 3 0 0 3 3 3 2 Phosphatidylinositol 3- and 4-kinase DUF2852 PF11014.8 CDI81913.1 - 2.7 8.2 6.3 75 3.5 2.6 3.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) CAF1 PF04857.20 CDI81913.1 - 4.9 6.2 11.9 44 3.1 0.1 3.5 2 0 0 2 2 2 0 CAF1 family ribonuclease ELO PF01151.18 CDI81915.1 - 3.6e-47 161.0 18.1 3.6e-47 161.0 18.1 2.2 2 1 0 2 2 2 1 GNS1/SUR4 family PTS_EIIC_2 PF13303.6 CDI81915.1 - 0.0061 15.6 0.4 0.0061 15.6 0.4 2.4 3 0 0 3 3 3 1 Phosphotransferase system, EIIC DUF1765 PF08578.10 CDI81916.1 - 1.2e-14 54.8 0.4 2.4e-14 53.9 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) SR-25 PF10500.9 CDI81916.1 - 3.2 7.3 22.4 0.15 11.7 14.9 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI81917.1 - 0.0018 17.9 9.5 0.0018 17.9 9.5 7.3 4 2 2 6 6 6 3 Nuclear RNA-splicing-associated protein FAM76 PF16046.5 CDI81917.1 - 0.0049 16.3 4.6 0.0049 16.3 4.6 3.3 3 0 0 3 3 3 1 FAM76 protein Tim54 PF11711.8 CDI81917.1 - 9.6 4.9 18.3 0.56 8.9 11.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SR-25 PF10500.9 CDI81918.1 - 0.026 14.1 5.4 0.026 14.2 5.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3318 PF11780.8 CDI81918.1 - 1.2 9.1 10.1 0.034 14.1 3.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3318) RskA PF10099.9 CDI81919.1 - 0.00011 22.5 6.4 0.00011 22.5 6.4 2.9 1 1 1 3 3 3 1 Anti-sigma-K factor rskA AF-4 PF05110.13 CDI81919.1 - 0.0033 15.6 27.2 0.0037 15.4 27.2 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Velvet PF11754.8 CDI81919.1 - 0.023 14.7 15.7 0.034 14.1 15.7 1.3 1 0 0 1 1 1 0 Velvet factor PAT1 PF09770.9 CDI81919.1 - 0.91 7.7 30.2 0.9 7.7 30.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2464 PF10240.9 CDI81919.1 - 2 7.9 14.6 0.34 10.4 10.9 1.4 2 0 0 2 2 2 0 Multivesicular body subunit 12 Paramyxo_ncap PF00973.19 CDI81919.1 - 3.2 6.6 14.6 3.2 6.5 14.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Hamartin PF04388.12 CDI81919.1 - 3.5 6.2 22.3 4.9 5.7 22.3 1.2 1 0 0 1 1 1 0 Hamartin protein SPX PF03105.19 CDI81920.1 - 0.0043 17.0 25.2 0.0057 16.6 25.2 1.2 1 0 0 1 1 1 1 SPX domain TFIIF_alpha PF05793.12 CDI81920.1 - 0.0082 14.8 23.8 0.012 14.2 23.8 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Peptidase_S64 PF08192.11 CDI81920.1 - 0.015 13.9 28.8 0.018 13.6 28.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 Atg14 PF10186.9 CDI81920.1 - 0.046 12.8 25.6 0.067 12.3 25.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CRT10 PF08728.10 CDI81920.1 - 0.1 10.7 11.3 0.11 10.7 11.3 1.1 1 0 0 1 1 1 0 CRT10 Lin-8 PF03353.15 CDI81920.1 - 0.66 9.5 42.3 1.1 8.8 42.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4551 PF15087.6 CDI81920.1 - 4.7 5.9 25.6 7 5.4 25.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) VIR_N PF15912.5 CDI81920.1 - 5.5 6.5 22.3 8.5 5.9 22.3 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal UPF0564 PF10595.9 CDI81920.1 - 10 5.1 45.8 13 4.7 45.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 CHD5 PF04420.14 CDI81922.1 - 1.9e-06 27.9 1.4 1.9e-06 27.9 1.4 1.6 2 0 0 2 2 2 1 CHD5-like protein CAP59_mtransfer PF11735.8 CDI81922.1 - 0.12 12.0 2.2 0.18 11.5 2.2 1.2 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 DUF5345 PF17280.2 CDI81922.1 - 7.2 6.7 8.6 5.5 7.0 2.5 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5345) zf-ZPR1 PF03367.13 CDI81924.1 - 1.2e-69 233.2 0.1 2.3e-37 128.3 0.0 2.6 3 0 0 3 3 3 2 ZPR1 zinc-finger domain SR-25 PF10500.9 CDI81924.1 - 0.0059 16.3 17.5 0.013 15.1 17.5 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 CDI81924.1 - 0.16 10.5 10.6 0.26 9.8 10.6 1.4 1 0 0 1 1 1 0 Macoilin family DUF3446 PF11928.8 CDI81924.1 - 1.4 9.2 14.5 2.2 8.6 11.9 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain CCDC106 PF15794.5 CDI81924.1 - 2.1 8.0 13.9 4.5 6.9 13.9 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Spem1 PF15670.5 CDI81924.1 - 2.3 7.7 5.5 4.5 6.8 5.5 1.5 1 0 0 1 1 1 0 Spermatid maturation protein 1 AF-4 PF05110.13 CDI81924.1 - 2.8 5.9 25.6 3.9 5.4 25.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Raftlin PF15250.6 CDI81924.1 - 4.3 6.0 10.5 6.6 5.4 10.5 1.3 1 0 0 1 1 1 0 Raftlin Apt1 PF10351.9 CDI81924.1 - 7.9 5.2 15.5 12 4.6 15.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain THOC2_N PF16134.5 CDI81926.1 - 1.4e-05 24.0 0.5 2.4e-05 23.2 0.5 1.4 1 1 0 1 1 1 1 THO complex subunit 2 N-terminus Spt20 PF12090.8 CDI81926.1 - 0.0041 16.8 16.0 0.0041 16.8 16.0 2.6 2 1 0 2 2 2 1 Spt20 family SR-25 PF10500.9 CDI81926.1 - 0.0067 16.1 16.8 0.049 13.2 1.2 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein eIF-3_zeta PF05091.12 CDI81926.1 - 0.064 12.2 5.3 0.086 11.8 5.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4834 PF16118.5 CDI81926.1 - 0.66 11.0 11.9 2 9.4 6.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CDI81926.1 - 7.9 7.2 23.6 3.3 8.4 6.7 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Tho2 PF11262.8 CDI81928.1 - 6.1e-39 134.0 0.0 6.1e-39 134.0 0.0 3.5 4 1 1 5 5 5 2 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 CDI81928.1 - 3.2e-12 45.9 0.0 3.2e-12 45.9 0.0 3.1 3 0 0 3 3 3 1 THO complex subunit 2 N-terminus Thoc2 PF11732.8 CDI81928.1 - 0.037 14.1 0.0 0.092 12.8 0.0 1.6 1 0 0 1 1 1 0 Transcription- and export-related complex subunit HEPN_AbiV PF18728.1 CDI81928.1 - 0.27 11.4 3.3 1.2 9.3 3.8 1.7 2 0 0 2 2 2 0 AbiV CCDC53 PF10152.9 CDI81929.1 - 2.4 8.5 18.0 33 4.9 18.0 2.7 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex ABC_tran PF00005.27 CDI81930.1 - 8.8e-08 32.8 12.3 1.1e-07 32.4 0.0 2.5 2 1 0 2 2 2 1 ABC transporter DUF2722 PF10846.8 CDI81930.1 - 7.4e-06 25.2 16.6 9.3e-06 24.8 16.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) AAA_21 PF13304.6 CDI81930.1 - 0.0005 20.0 0.0 0.00078 19.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system FAM76 PF16046.5 CDI81930.1 - 0.0045 16.4 15.3 0.006 16.0 15.3 1.1 1 0 0 1 1 1 1 FAM76 protein Velvet PF11754.8 CDI81930.1 - 0.011 15.8 5.8 0.014 15.4 5.8 1.3 1 0 0 1 1 1 0 Velvet factor Plasmodium_Vir PF05795.11 CDI81930.1 - 0.023 14.1 4.0 0.03 13.7 4.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RICTOR_N PF14664.6 CDI81930.1 - 0.06 12.3 0.5 0.098 11.6 0.5 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term PepSY_TM_like_2 PF16357.5 CDI81930.1 - 0.071 13.1 5.5 0.14 12.1 5.5 1.4 1 0 0 1 1 1 0 Putative PepSY_TM-like Rtf2 PF04641.12 CDI81930.1 - 0.11 11.8 7.9 0.097 12.0 6.4 1.5 1 1 0 1 1 1 0 Rtf2 RING-finger Androgen_recep PF02166.16 CDI81930.1 - 0.12 11.2 21.5 0.23 10.3 21.5 1.4 1 0 0 1 1 1 0 Androgen receptor Band_3_cyto PF07565.13 CDI81930.1 - 0.12 12.1 9.5 0.16 11.7 9.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TFIIA PF03153.13 CDI81930.1 - 0.13 12.3 27.7 0.19 11.7 27.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CTNNB1_binding PF08347.11 CDI81930.1 - 0.15 12.3 9.1 0.2 11.8 9.1 1.1 1 0 0 1 1 1 0 N-terminal CTNNB1 binding Coilin_N PF15862.5 CDI81930.1 - 0.18 11.6 10.8 0.46 10.3 10.8 1.6 1 0 0 1 1 1 0 Coilin N-terminus DUF4746 PF15928.5 CDI81930.1 - 0.54 9.6 7.5 0.75 9.2 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Hid1 PF12722.7 CDI81930.1 - 1.4 7.0 10.2 1.7 6.7 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Usp PF00582.26 CDI81930.1 - 1.8 9.1 5.1 2.6 8.6 3.8 2.0 2 0 0 2 2 2 0 Universal stress protein family CLN3 PF02487.17 CDI81930.1 - 1.9 7.4 5.2 2.4 7.1 5.2 1.2 1 0 0 1 1 1 0 CLN3 protein Sox_N PF12444.8 CDI81930.1 - 2.1 9.5 8.3 2.8 9.1 7.2 1.8 2 0 0 2 2 1 0 Sox developmental protein N terminal PepSY_TM PF03929.16 CDI81930.1 - 2.2 7.9 3.7 2.9 7.5 3.7 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Ureide_permease PF07168.11 CDI81930.1 - 2.3 6.9 4.1 3.3 6.4 4.1 1.2 1 0 0 1 1 1 0 Ureide permease SLC12 PF03522.15 CDI81930.1 - 2.7 6.9 10.4 3.5 6.5 10.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF3464 PF11947.8 CDI81930.1 - 2.8 7.7 9.7 5.3 6.8 9.7 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 EOS1 PF12326.8 CDI81930.1 - 2.8 7.8 4.2 5.1 7.0 4.2 1.4 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.19 CDI81930.1 - 3.1 7.5 6.6 5.1 6.8 6.6 1.4 1 0 0 1 1 1 0 Connexin CobT PF06213.12 CDI81930.1 - 3.7 6.8 20.5 7.3 5.9 20.5 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Serinc PF03348.15 CDI81930.1 - 6.3 5.6 5.3 8 5.3 5.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.22 CDI81930.1 - 6.5 5.9 5.1 7.7 5.6 5.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MAJIN PF15077.6 CDI81930.1 - 6.7 6.4 9.5 12 5.6 9.5 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein Roughex PF06020.11 CDI81930.1 - 7.2 5.6 13.2 10 5.1 13.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein MMR1 PF08505.10 CDI81930.1 - 9.9 6.4 17.7 14 5.9 17.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAP1 PF08601.10 CDI81931.1 - 0.00035 20.4 0.2 0.00047 20.0 0.2 1.1 1 0 0 1 1 1 1 Transcription factor PAP1 CCDC24 PF15669.5 CDI81931.1 - 0.04 13.8 3.3 0.058 13.3 3.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family SR-25 PF10500.9 CDI81931.1 - 0.56 9.8 16.7 1 8.9 16.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ashwin PF15323.6 CDI81931.1 - 4.9 7.1 6.6 7 6.6 6.6 1.1 1 0 0 1 1 1 0 Developmental protein TRAPPC10 PF12584.8 CDI81932.1 - 7.8e-05 22.4 0.3 0.00047 19.9 0.0 2.6 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 AUX_IAA PF02309.16 CDI81932.1 - 0.16 11.8 0.0 0.16 11.8 0.0 5.6 5 1 0 5 5 5 0 AUX/IAA family DUF4597 PF15366.6 CDI81932.1 - 3.7 7.4 5.7 2.6 7.8 0.2 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) Ribosomal_L30 PF00327.20 CDI81933.1 - 0.0018 18.1 0.3 0.0045 16.9 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CDI81933.1 - 0.65 10.3 18.6 0.82 10.0 17.7 1.6 1 1 1 2 2 2 0 Ribosomal L30 N-terminal domain TRM PF02005.16 CDI81934.1 - 4.7e-85 286.0 0.0 3.1e-44 151.7 0.0 3.1 3 0 0 3 3 3 3 N2,N2-dimethylguanosine tRNA methyltransferase TFIIA PF03153.13 CDI81934.1 - 0.0038 17.3 9.7 0.0038 17.3 9.7 2.4 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Miga PF10265.9 CDI81934.1 - 0.88 8.5 7.2 1.4 7.8 7.2 1.2 1 0 0 1 1 1 0 Mitoguardin SUIM_assoc PF16619.5 CDI81934.1 - 1.1 9.4 20.4 1.8 8.7 10.3 3.1 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Macoilin PF09726.9 CDI81934.1 - 2.1 6.8 13.7 3.6 6.0 13.7 1.2 1 0 0 1 1 1 0 Macoilin family CpXC PF14353.6 CDI81934.1 - 6.1 6.9 6.0 0.59 10.2 0.9 2.0 2 0 0 2 2 2 0 CpXC protein SDA1 PF05285.12 CDI81935.1 - 0.017 14.5 13.9 0.03 13.8 13.9 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CDI81935.1 - 0.13 10.5 9.3 0.19 10.0 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 CDI81935.1 - 2.6 6.2 15.6 3.7 5.6 15.6 1.1 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 CDI81935.1 - 4.9 6.3 5.2 8.5 5.5 5.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4044 PF13253.6 CDI81936.1 - 0.21 11.1 0.0 0.39 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) Tau95 PF09734.9 CDI81937.1 - 1.1e-05 26.3 7.9 0.0022 18.8 0.0 3.1 3 0 0 3 3 3 2 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 CDI81937.1 - 0.018 15.3 11.5 0.33 11.1 0.0 4.4 3 1 1 4 4 4 0 Tau95 Triple barrel domain RAB3GAP2_N PF14655.6 CDI81937.1 - 1.7 7.8 10.0 0.58 9.3 2.7 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus GDI PF00996.18 CDI81938.1 - 1.7e-13 49.9 0.0 1.4e-06 27.1 0.0 3.2 3 0 0 3 3 3 3 GDP dissociation inhibitor DUF2722 PF10846.8 CDI81938.1 - 0.26 10.2 0.0 0.26 10.2 0.0 10.1 7 2 3 10 10 10 0 Protein of unknown function (DUF2722) DUF4781 PF16013.5 CDI81938.1 - 1.3 7.7 0.0 1.3 7.7 0.0 4.8 4 1 0 4 4 4 0 Domain of unknown function (DUF4781) Mitoc_mL59 PF18126.1 CDI81940.1 - 0.00025 21.4 4.0 0.003 17.9 3.6 2.2 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Nnf1 PF03980.14 CDI81940.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Nnf1 Ank_4 PF13637.6 CDI81941.1 - 7e-22 77.5 0.3 6e-11 42.7 0.0 5.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI81941.1 - 4.7e-21 75.2 0.3 2.6e-16 60.0 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDI81941.1 - 5.4e-17 60.1 5.7 8.9e-06 25.7 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 CDI81941.1 - 8.4e-16 57.6 6.9 4.5e-05 23.7 0.2 6.1 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 CDI81941.1 - 1.1e-14 54.2 2.0 1.4e-10 41.2 0.2 4.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) SET PF00856.28 CDI81941.1 - 0.00023 21.6 0.0 0.0014 19.0 0.0 2.4 2 1 0 2 2 2 1 SET domain AAA PF00004.29 CDI81944.1 - 1.5e-26 93.3 0.0 5.5e-26 91.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDI81944.1 - 2.3e-18 65.9 0.0 4.5e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CDI81944.1 - 9.1e-12 44.6 0.1 2e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain DUF5001 PF16392.5 CDI81944.1 - 0.031 14.2 0.0 0.31 11.0 0.0 2.3 2 0 0 2 2 2 0 Ig-like domain AAA_2 PF07724.14 CDI81944.1 - 0.061 13.4 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) CENP-F_leu_zip PF10473.9 CDI81944.1 - 0.069 13.2 2.0 0.34 10.9 1.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 CDI81944.1 - 0.11 13.0 3.6 0.2 12.1 1.7 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Exo_endo_phos PF03372.23 CDI81945.1 - 1.4e-11 44.4 0.0 5.2e-11 42.5 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TFIIA PF03153.13 CDI81950.1 - 0.03 14.3 40.0 0.036 14.1 40.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 CDI81950.1 - 0.042 13.4 21.5 0.051 13.1 21.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hamartin PF04388.12 CDI81950.1 - 0.18 10.4 17.0 0.2 10.3 17.0 1.0 1 0 0 1 1 1 0 Hamartin protein SPX PF03105.19 CDI81950.1 - 0.26 11.2 22.6 0.33 10.8 22.6 1.2 1 0 0 1 1 1 0 SPX domain Myc_N PF01056.18 CDI81950.1 - 0.33 10.8 15.7 0.43 10.4 15.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region CDK5_activator PF03261.15 CDI81950.1 - 0.36 10.3 17.1 0.43 10.1 17.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein VIR_N PF15912.5 CDI81950.1 - 0.36 10.4 14.0 0.4 10.2 14.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal MAP7 PF05672.11 CDI81950.1 - 0.39 10.4 39.5 0.8 9.4 39.5 1.5 1 1 0 1 1 1 0 MAP7 (E-MAP-115) family RR_TM4-6 PF06459.12 CDI81950.1 - 0.51 10.1 20.6 0.68 9.7 20.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF966 PF06136.13 CDI81950.1 - 1.1 8.9 19.5 1.3 8.7 19.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) NOA36 PF06524.12 CDI81950.1 - 1.4 8.1 10.6 1.8 7.8 10.6 1.2 1 0 0 1 1 1 0 NOA36 protein Menin PF05053.13 CDI81950.1 - 1.5 7.1 24.9 1.9 6.8 24.9 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 CDI81950.1 - 1.8 7.5 22.3 2.4 7.1 22.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 CDI81950.1 - 3.2 6.5 19.1 4.1 6.1 19.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Suf PF05843.14 CDI81950.1 - 3.6 7.5 23.5 4.9 7.0 23.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Smg8_Smg9 PF10220.9 CDI81950.1 - 5.9 5.1 18.7 7.1 4.8 18.7 1.2 1 0 0 1 1 1 0 Smg8_Smg9 PAT1 PF09770.9 CDI81950.1 - 6.4 4.9 31.4 7.3 4.7 31.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0492 PF15744.5 CDI81950.1 - 8 5.6 29.2 10 5.2 29.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 RIFIN PF02009.16 CDI81950.1 - 8.1 6.2 13.1 11 5.8 13.1 1.2 1 0 0 1 1 1 0 Rifin SAPS PF04499.15 CDI81950.1 - 8.6 5.0 18.2 11 4.7 18.2 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Acyltransferase PF01553.21 CDI81951.1 - 3.7e-08 33.1 0.1 0.00011 21.8 0.0 2.4 2 0 0 2 2 2 2 Acyltransferase Mucin PF01456.17 CDI81951.1 - 0.011 15.7 15.7 0.011 15.7 15.7 4.4 3 1 0 4 4 4 0 Mucin-like glycoprotein TMEM151 PF14857.6 CDI81951.1 - 8.9 5.1 0.0 8.9 5.1 0.0 3.1 2 1 1 3 3 3 0 TMEM151 family Ku_N PF03731.15 CDI81953.1 - 0.0061 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain DUF4228 PF14009.6 CDI81953.1 - 0.019 15.3 3.0 1.8 8.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) SR-25 PF10500.9 CDI81953.1 - 0.94 9.0 40.7 0.49 10.0 13.4 2.7 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Lin-8 PF03353.15 CDI81953.1 - 3.7 7.0 13.9 0.81 9.2 3.2 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist NAM-associated PF14303.6 CDI81953.1 - 5.5 7.7 11.0 6.1 7.5 0.2 2.4 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain CCDC106 PF15794.5 CDI81953.1 - 7.6 6.2 18.9 1.7 8.3 4.7 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 TraG-D_C PF12696.7 CDI81953.1 - 8.3 6.4 14.0 11 6.0 3.1 3.2 3 0 0 3 3 3 0 TraM recognition site of TraD and TraG Mitofilin PF09731.9 CDI81956.1 - 0.12 11.2 5.2 0.1 11.4 0.9 2.0 2 0 0 2 2 2 0 Mitochondrial inner membrane protein SR-25 PF10500.9 CDI81956.1 - 2.6 7.6 28.8 2.7 7.6 14.0 3.1 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Kinesin PF00225.23 CDI81958.1 - 7e-09 35.1 0.0 1.4e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain SPX PF03105.19 CDI81958.1 - 0.21 11.4 5.6 0.26 11.1 5.6 1.2 1 0 0 1 1 1 0 SPX domain RskA PF10099.9 CDI81959.1 - 0.0019 18.5 29.3 0.084 13.2 8.8 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF2076 PF09849.9 CDI81959.1 - 0.0074 16.4 21.9 0.009 16.1 21.9 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF755 PF05501.11 CDI81959.1 - 0.033 14.5 30.0 0.033 14.5 30.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Peptidase_S49_N PF08496.10 CDI81959.1 - 0.034 14.2 10.9 0.65 10.0 0.9 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SPX PF03105.19 CDI81959.1 - 0.05 13.5 16.1 0.061 13.2 16.1 1.1 1 0 0 1 1 1 0 SPX domain SelP_N PF04592.14 CDI81959.1 - 0.3 10.4 20.5 0.16 11.3 9.4 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region SID-1_RNA_chan PF13965.6 CDI81959.1 - 0.36 9.2 6.4 0.43 8.9 6.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SARAF PF06682.12 CDI81959.1 - 1 8.9 21.2 1.1 8.9 11.9 2.0 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis TERB2 PF15101.6 CDI81959.1 - 1.2 9.2 23.6 2 8.4 2.7 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Activator_LAG-3 PF11498.8 CDI81959.1 - 2.5 7.0 40.0 0.48 9.3 10.8 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF1635 PF07795.11 CDI81959.1 - 2.5 7.9 24.1 1.7 8.5 15.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) SR-25 PF10500.9 CDI81959.1 - 3.1 7.3 40.1 6.5 6.3 31.4 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDI81959.1 - 3.3 7.3 24.1 3.7 7.2 16.9 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF4667 PF15700.5 CDI81959.1 - 3.6 7.6 31.6 4 7.5 19.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) CNDH2_M PF16869.5 CDI81959.1 - 3.7 8.2 18.0 1.8 9.2 9.1 2.3 2 0 0 2 2 2 0 PF16858 Afi1 PF07792.12 CDI81959.1 - 4.1 7.9 16.6 8.8 6.8 9.7 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Phostensin_N PF13916.6 CDI81959.1 - 4.3 7.7 15.0 3.5 8.0 3.5 2.7 2 1 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal G0-G1_switch_2 PF15103.6 CDI81959.1 - 4.8 7.7 11.9 9.1 6.8 0.7 2.4 2 0 0 2 2 2 0 G0/G1 switch protein 2 PAP1 PF08601.10 CDI81959.1 - 5.6 6.6 23.1 7 6.3 23.1 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 RAP1 PF07218.11 CDI81959.1 - 5.6 5.1 10.5 6.5 4.9 10.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) EPL1 PF10513.9 CDI81959.1 - 6.3 7.2 20.6 4.3 7.7 2.6 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like Apc15p PF05841.11 CDI81959.1 - 6.7 7.5 23.7 7.3 7.4 1.7 2.2 2 0 0 2 2 2 0 Apc15p protein GREB1 PF15782.5 CDI81959.1 - 7 3.6 28.5 8.2 3.4 28.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SUIM_assoc PF16619.5 CDI81960.1 - 7.1e-05 22.8 8.9 0.032 14.3 5.4 2.7 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI81960.1 - 0.79 9.3 18.9 0.062 12.9 10.8 2.1 2 0 0 2 2 2 0 Spt20 family RAB3GAP2_N PF14655.6 CDI81960.1 - 1.6 7.9 6.2 5.1 6.3 0.5 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF21 PF01595.20 CDI81961.1 - 5.6e-13 49.0 0.2 7.6e-13 48.5 0.2 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain YrhC PF14143.6 CDI81961.1 - 0.005 16.9 1.3 0.0087 16.1 1.3 1.4 1 0 0 1 1 1 1 YrhC-like protein AIM3 PF17096.5 CDI81962.1 - 1.5 9.8 8.3 7 7.7 0.2 3.1 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 3 Glyoxalase_3 PF13468.6 CDI81967.1 - 0.00066 19.8 0.4 0.0018 18.4 0.4 1.7 1 0 0 1 1 1 1 Glyoxalase-like domain Ras PF00071.22 CDI81970.1 - 1.5e-36 125.4 0.1 9.9e-19 67.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CDI81970.1 - 2.3e-17 63.3 0.1 1.3e-12 48.0 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI81970.1 - 0.012 15.1 0.1 3.7 7.0 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CDI81970.1 - 0.018 14.9 0.0 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 CDI81970.1 - 0.14 11.9 0.1 0.16 11.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDI81970.1 - 0.15 12.4 0.1 1.4 9.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain Suf PF05843.14 CDI81971.1 - 7.8e-06 26.1 0.6 0.00012 22.2 0.3 2.1 1 1 1 2 2 2 2 Suppressor of forked protein (Suf) TPR_2 PF07719.17 CDI81971.1 - 0.009 16.1 3.5 0.45 10.8 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI81971.1 - 0.0096 16.7 4.6 0.3 12.0 2.1 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat HAT PF02184.16 CDI81971.1 - 0.059 13.3 9.6 6.3 6.8 0.3 4.0 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat Glyco_transf_88 PF16849.5 CDI81971.1 - 0.12 11.3 0.1 0.12 11.3 0.1 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 88 ABC_tran_CTD PF16326.5 CDI81971.1 - 0.32 11.3 4.5 0.094 13.0 1.8 1.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain TPR_6 PF13174.6 CDI81971.1 - 0.6 10.9 3.5 6 7.7 0.7 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S25 PF03297.15 CDI81978.1 - 8.7e-41 138.2 1.6 9.6e-41 138.1 1.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.7 CDI81978.1 - 0.022 14.6 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 MarR family Mt_ATP-synt_D PF05873.12 CDI81978.1 - 0.053 13.4 1.4 0.071 13.0 1.4 1.1 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Fe_dep_repress PF01325.19 CDI81978.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Trp_halogenase PF04820.14 CDI81978.1 - 0.15 10.9 0.1 0.17 10.7 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Rrf2 PF02082.20 CDI81978.1 - 0.15 12.4 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator Trp_oprn_chp PF09534.10 CDI81979.1 - 0.062 13.1 8.3 0.11 12.2 8.3 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) OAD_gamma PF04277.13 CDI81980.1 - 1.5 9.5 0.0 1.5 9.5 0.0 3.0 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF2362 PF10154.9 CDI81982.1 - 5.2e-07 29.0 0.0 5.2e-07 29.0 0.0 4.3 4 2 0 4 4 4 2 Uncharacterized conserved protein (DUF2362) Ank_2 PF12796.7 CDI81983.1 - 2.7e-05 24.7 0.1 0.0001 22.8 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI81983.1 - 0.0035 17.9 0.0 0.01 16.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDI81983.1 - 0.0062 16.9 0.5 0.1 13.2 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 CDI81983.1 - 0.055 13.9 0.0 0.055 13.9 0.0 3.2 4 0 0 4 4 4 0 Ankyrin repeat Methyltransf_25 PF13649.6 CDI81983.1 - 0.11 13.2 0.0 0.42 11.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDI81983.1 - 0.14 12.0 0.1 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain DENN PF02141.21 CDI81985.1 - 7.3e-09 35.8 13.5 3e-08 33.8 1.6 3.0 3 0 0 3 3 3 2 DENN (AEX-3) domain uDENN PF03456.18 CDI81985.1 - 4e-06 27.5 10.1 7.6e-06 26.6 0.1 3.9 4 0 0 4 4 4 2 uDENN domain DUF681 PF05080.12 CDI81986.1 - 0.037 14.7 0.0 0.16 12.6 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF681) LSM PF01423.22 CDI81987.1 - 9.1e-17 60.5 0.8 1.1e-16 60.2 0.8 1.1 1 0 0 1 1 1 1 LSM domain DUF3093 PF11292.8 CDI81989.1 - 0.0069 16.7 0.6 0.0069 16.7 0.6 2.8 3 1 1 4 4 4 1 Protein of unknown function (DUF3093) TMEM234 PF10639.9 CDI81991.1 - 3.5e-16 59.3 0.3 4e-16 59.1 0.3 1.0 1 0 0 1 1 1 1 Putative transmembrane family 234 TLC PF03219.14 CDI81991.1 - 0.098 11.4 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 TLC ATP/ADP transporter Kinase-like PF14531.6 CDI81992.1 - 5.3e-10 39.1 0.0 1.4e-09 37.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.25 CDI81992.1 - 1.6e-09 37.6 0.8 2e-09 37.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI81992.1 - 0.0038 16.6 0.0 0.0085 15.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase TFIIA PF03153.13 CDI81992.1 - 0.0088 16.1 9.2 0.012 15.6 9.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit bZIP_Maf PF03131.17 CDI81992.1 - 3 8.4 14.7 6 7.5 14.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor RrnaAD PF00398.20 CDI81993.1 - 3.2e-22 78.9 0.0 3.6e-22 78.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CDI81993.1 - 4.2e-08 33.8 0.0 6.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI81993.1 - 3.9e-06 26.7 0.0 5.3e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI81993.1 - 0.0002 22.0 0.0 0.00034 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI81993.1 - 0.0011 19.7 0.0 0.0017 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI81993.1 - 0.0016 18.3 0.0 0.0019 18.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDI81993.1 - 0.0048 16.3 0.0 0.006 16.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF43 PF01861.16 CDI81993.1 - 0.006 15.8 0.0 0.0083 15.4 0.0 1.2 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Methyltransf_4 PF02390.17 CDI81993.1 - 0.0093 15.5 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase NodS PF05401.11 CDI81993.1 - 0.016 14.8 0.0 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) PCMT PF01135.19 CDI81993.1 - 0.03 14.1 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 CDI81993.1 - 0.099 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Herpes_BLLF1 PF05109.13 CDI81993.1 - 0.12 10.4 2.1 0.15 10.0 2.1 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) DREV PF05219.12 CDI81993.1 - 0.15 11.2 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase GCP_N_terminal PF17681.1 CDI81994.1 - 7.3e-24 84.9 0.0 1.5e-22 80.6 0.0 2.4 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal SR-25 PF10500.9 CDI81994.1 - 1 8.9 18.0 1.5 8.3 18.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI81994.1 - 3.1 8.1 33.2 2 8.6 7.0 2.6 2 0 0 2 2 2 0 Anti-sigma-K factor rskA PHD PF00628.29 CDI81995.1 - 4.9e-06 26.3 4.8 4.9e-06 26.3 4.8 2.5 2 0 0 2 2 2 1 PHD-finger FGE-sulfatase PF03781.16 CDI82002.1 - 0.027 14.0 0.3 0.047 13.3 0.3 1.3 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 V-SNARE_C PF12352.8 CDI82003.1 - 1.5e-06 28.3 0.2 1.1e-05 25.6 0.2 2.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Pkinase PF00069.25 CDI82004.1 - 2.4e-14 53.3 4.0 3.3e-14 52.9 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82004.1 - 6.2e-07 29.0 0.0 2.9e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase XRCC4 PF06632.12 CDI82005.1 - 4.2e-05 22.6 0.8 4.2e-05 22.6 0.8 3.4 2 1 0 3 3 3 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Notch PF00066.17 CDI82006.1 - 7.3e-07 29.5 8.3 7.3e-07 29.5 8.3 2.9 2 0 0 2 2 2 1 LNR domain Big_5 PF13205.6 CDI82006.1 - 9.4e-07 29.5 0.0 0.21 12.3 0.0 4.6 3 1 1 4 4 4 1 Bacterial Ig-like domain DUF4381 PF14316.6 CDI82006.1 - 0.0092 16.2 0.4 0.0092 16.2 0.4 4.5 5 0 0 5 5 5 1 Domain of unknown function (DUF4381) SIT PF15330.6 CDI82006.1 - 0.029 14.8 7.1 0.031 14.7 0.0 3.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 CDI82006.1 - 0.1 13.5 1.1 13 6.7 0.0 3.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF5385 PF17359.2 CDI82006.1 - 0.3 10.6 2.6 3.3 7.2 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5385) MscS_TM PF12794.7 CDI82006.1 - 1.1 8.1 6.6 1.3 7.8 0.5 2.8 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 CcmH PF03918.14 CDI82006.1 - 8.2 5.7 8.3 1.9 7.8 0.2 3.1 3 0 0 3 3 3 0 Cytochrome C biogenesis protein F420_oxidored PF03807.17 CDI82010.1 - 3.1e-05 24.5 0.0 0.00011 22.7 0.0 1.9 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 CDI82010.1 - 0.016 14.2 0.0 0.024 13.7 0.0 1.1 1 0 0 1 1 1 0 Prephenate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CDI82010.1 - 0.024 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 CDI82010.1 - 0.044 13.4 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.22 CDI82010.1 - 0.1 13.4 0.0 0.2 12.5 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DAO PF01266.24 CDI82010.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase IlvN PF07991.12 CDI82010.1 - 0.14 11.8 0.0 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Spt20 PF12090.8 CDI82011.1 - 0.00012 21.8 18.8 0.00018 21.2 18.8 1.3 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI82011.1 - 0.00012 21.2 12.4 0.00016 20.8 12.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI82011.1 - 0.00025 21.2 20.8 0.00034 20.8 20.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI82011.1 - 0.00033 21.0 17.1 0.0035 17.7 1.8 2.2 2 0 0 2 2 2 2 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI82011.1 - 0.001 18.2 3.5 0.0012 17.9 3.5 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Velvet PF11754.8 CDI82011.1 - 0.0052 16.8 2.7 0.0064 16.5 2.7 1.2 1 0 0 1 1 1 1 Velvet factor TERB2 PF15101.6 CDI82011.1 - 0.0075 16.3 5.9 0.012 15.7 5.9 1.4 1 0 0 1 1 1 1 Telomere-associated protein TERB2 DDHD PF02862.17 CDI82011.1 - 0.0083 16.3 2.2 0.01 16.0 2.2 1.3 1 0 0 1 1 1 1 DDHD domain Presenilin PF01080.17 CDI82011.1 - 0.01 14.7 5.3 0.012 14.4 5.3 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CDI82011.1 - 0.013 13.9 12.1 0.015 13.6 12.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4100 PF13352.6 CDI82011.1 - 0.015 15.1 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) Pex14_N PF04695.13 CDI82011.1 - 0.022 15.4 19.2 0.037 14.7 19.2 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EPL1 PF10513.9 CDI82011.1 - 0.025 15.0 3.9 0.036 14.5 3.9 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like PDDEXK_6 PF04720.12 CDI82011.1 - 0.031 14.2 8.3 0.085 12.8 8.4 1.6 2 0 0 2 2 2 0 PDDEXK-like family of unknown function MMR1 PF08505.10 CDI82011.1 - 0.033 14.5 4.3 0.047 14.0 4.3 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Connexin PF00029.19 CDI82011.1 - 0.038 13.7 2.3 0.056 13.2 2.3 1.2 1 0 0 1 1 1 0 Connexin RICTOR_N PF14664.6 CDI82011.1 - 0.053 12.5 1.0 0.068 12.1 1.0 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term UPF0560 PF10577.9 CDI82011.1 - 0.089 11.3 10.5 0.11 11.0 10.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Baculo_PP31 PF05311.11 CDI82011.1 - 0.092 12.2 3.7 0.14 11.6 3.7 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF868 PF05910.12 CDI82011.1 - 0.11 12.2 3.2 0.16 11.6 3.2 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF868) EOS1 PF12326.8 CDI82011.1 - 0.11 12.4 1.6 0.14 12.1 0.3 1.8 2 0 0 2 2 2 0 N-glycosylation protein SAM35 PF10806.8 CDI82011.1 - 0.13 12.5 3.7 0.24 11.7 3.7 1.3 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex Orf78 PF06024.12 CDI82011.1 - 0.2 12.0 3.9 0.08 13.2 1.4 1.7 2 0 0 2 2 1 0 Orf78 (ac78) Ribosomal_60s PF00428.19 CDI82011.1 - 0.21 12.2 19.7 1.6 9.4 10.5 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Med15 PF09606.10 CDI82011.1 - 0.27 9.9 22.3 0.35 9.5 22.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal EIF4E-T PF10477.9 CDI82011.1 - 0.33 9.7 11.3 0.41 9.4 11.3 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E MDFI PF15316.6 CDI82011.1 - 0.35 10.9 4.5 0.55 10.3 4.5 1.3 1 0 0 1 1 1 0 MyoD family inhibitor FAM60A PF15396.6 CDI82011.1 - 0.36 10.8 4.1 0.53 10.3 4.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A ALG3 PF05208.13 CDI82011.1 - 0.54 9.6 4.4 0.7 9.2 4.3 1.3 1 1 0 1 1 1 0 ALG3 protein DUF3371 PF11851.8 CDI82011.1 - 0.96 10.5 14.4 2 9.5 14.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Roughex PF06020.11 CDI82011.1 - 1 8.4 6.7 1.4 8.0 6.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Activator_LAG-3 PF11498.8 CDI82011.1 - 1 8.2 32.7 1.4 7.8 32.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MCR_alpha PF02249.17 CDI82011.1 - 1.4 9.4 15.4 7.6 7.0 15.6 2.2 1 1 1 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain FlaG PF03646.15 CDI82011.1 - 2 8.6 13.4 1.1e+02 3.1 15.8 2.1 2 0 0 2 2 2 0 FlaG protein Coilin_N PF15862.5 CDI82011.1 - 3.7 7.4 12.4 6.5 6.6 12.4 1.3 1 0 0 1 1 1 0 Coilin N-terminus MecA PF05389.12 CDI82011.1 - 4.3 6.9 11.2 8 6.0 11.3 1.5 1 1 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF4834 PF16118.5 CDI82011.1 - 7.3 7.6 12.7 14 6.7 12.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3464 PF11947.8 CDI82011.1 - 7.3 6.3 9.1 17 5.2 9.1 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 ZapB PF06005.12 CDI82014.1 - 1.9 9.0 0.0 1.9 9.0 0.0 5.3 4 2 0 4 4 4 0 Cell division protein ZapB SARAF PF06682.12 CDI82016.1 - 0.096 12.3 11.1 3.7 7.1 0.0 3.3 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Conotoxin PF02950.17 CDI82016.1 - 0.38 11.8 0.0 0.38 11.8 0.0 3.3 3 0 0 3 3 3 0 Conotoxin SPX PF03105.19 CDI82016.1 - 3.5 7.4 8.2 8.8 6.1 8.2 1.6 1 0 0 1 1 1 0 SPX domain Pex14_N PF04695.13 CDI82017.1 - 0.93 10.1 6.5 0.3 11.8 2.3 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_6 PF12774.7 CDI82019.1 - 1.6e-142 474.3 1.0 1.9e-141 470.8 0.1 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI82019.1 - 4.1e-101 339.0 2.8 4.1e-101 339.0 2.8 2.4 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.7 CDI82019.1 - 3.5e-69 231.9 0.0 1.6e-65 220.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_8 PF12780.7 CDI82019.1 - 1.7e-22 80.0 0.1 3.6e-22 78.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_lid_1 PF17857.1 CDI82019.1 - 2e-21 76.0 0.1 9.2e-21 73.9 0.1 2.2 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDI82019.1 - 2.5e-19 69.6 0.0 2.4e-06 27.6 0.0 6.5 6 1 0 6 6 6 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDI82019.1 - 1.7e-10 41.1 0.0 0.00081 19.5 0.0 2.9 1 1 1 2 2 2 2 Dynein heavy chain AAA lid domain AAA PF00004.29 CDI82019.1 - 2.3e-06 28.1 0.0 0.012 16.0 0.0 4.0 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI82019.1 - 5.5e-05 23.5 0.5 2.8 8.2 0.0 4.4 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 CDI82019.1 - 0.00079 19.8 2.6 0.88 9.9 0.0 5.2 6 1 0 6 6 5 1 AAA ATPase domain DUF853 PF05872.12 CDI82019.1 - 0.0033 16.1 0.7 0.2 10.2 0.1 2.2 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) AAA_30 PF13604.6 CDI82019.1 - 0.014 15.1 0.1 0.99 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDI82019.1 - 0.021 15.4 0.6 0.094 13.3 0.0 2.5 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 CDI82019.1 - 0.022 15.1 0.0 0.27 11.6 0.0 2.6 2 0 0 2 2 2 0 RNA helicase T2SSE PF00437.20 CDI82019.1 - 0.059 12.4 1.0 0.36 9.9 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 CDI82019.1 - 0.1 12.2 0.7 9.4 5.8 0.1 2.6 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CDI82019.1 - 0.14 11.6 0.2 7.3 5.9 0.0 3.1 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CDI82019.1 - 0.25 11.7 0.5 14 6.0 0.1 3.1 2 1 0 2 2 2 0 AAA domain AAA_9 PF12781.7 CDI82020.1 - 6.7e-48 162.7 11.5 3.5e-28 98.2 0.2 3.5 2 2 1 3 3 3 2 ATP-binding dynein motor region MT PF12777.7 CDI82020.1 - 2e-42 145.5 7.8 8.1e-40 136.9 2.9 2.1 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor DHR10 PF18595.1 CDI82020.1 - 0.00046 20.2 6.2 0.00046 20.2 6.2 4.1 3 1 0 3 3 2 1 Designed helical repeat protein 10 domain PI3K_P85_iSH2 PF16454.5 CDI82020.1 - 0.019 14.5 1.0 0.019 14.5 1.0 3.0 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_10 PF13374.6 CDI82020.1 - 0.093 12.6 2.5 1.3 9.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Fez1 PF06818.15 CDI82020.1 - 0.13 12.7 20.1 0.41 11.1 3.4 3.1 3 0 0 3 3 3 0 Fez1 TPR_2 PF07719.17 CDI82020.1 - 0.27 11.4 2.4 20 5.6 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat GIT_CC PF16559.5 CDI82020.1 - 0.6 10.0 9.3 0.36 10.7 1.8 3.2 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_1 PF00170.21 CDI82020.1 - 0.72 10.0 12.7 0.081 13.0 1.0 3.4 2 1 1 3 3 3 0 bZIP transcription factor PEARLI-4 PF05278.12 CDI82020.1 - 1.1 8.8 8.3 6.8 6.2 0.4 2.6 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) AIP3 PF03915.13 CDI82020.1 - 1.7 7.7 16.8 0.19 10.8 3.1 3.0 3 0 0 3 3 3 0 Actin interacting protein 3 YabA PF06156.13 CDI82020.1 - 3 8.5 10.3 5.4 7.7 0.5 2.8 2 0 0 2 2 2 0 Initiation control protein YabA DUF812 PF05667.11 CDI82020.1 - 3.3 6.5 18.4 0.21 10.5 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF812) COG2 PF06148.11 CDI82020.1 - 3.5 7.7 15.8 4.5 7.4 0.4 3.5 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin-6_N PF09177.11 CDI82020.1 - 8.7 7.0 15.9 33 5.1 0.6 3.8 3 1 0 3 3 3 0 Syntaxin 6, N-terminal AAA_lid_11 PF18198.1 CDI82021.1 - 7.9e-55 185.1 0.1 1.4e-54 184.4 0.1 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_C PF18199.1 CDI82021.1 - 2.5e-25 89.4 0.1 4.6e-25 88.5 0.1 1.4 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 CDI82021.1 - 3.6e-17 62.5 0.2 3.6e-10 40.0 0.1 2.8 2 1 1 3 3 3 2 Dynein heavy chain region D6 P-loop domain Creb_binding PF09030.10 CDI82024.1 - 0.006 17.3 0.8 0.006 17.3 0.8 2.2 2 0 0 2 2 2 2 Creb binding SF-assemblin PF06705.11 CDI82026.1 - 0.023 14.0 16.6 0.33 10.3 16.6 2.7 1 1 0 1 1 1 0 SF-assemblin/beta giardin BMF PF15185.6 CDI82026.1 - 0.026 14.2 1.9 0.034 13.9 1.9 1.2 1 0 0 1 1 1 0 Bcl-2-modifying factor, apoptosis Transposase_31 PF04754.12 CDI82026.1 - 0.12 12.0 2.9 0.094 12.3 1.6 1.5 1 1 1 2 2 2 0 Putative transposase, YhgA-like Fib_alpha PF08702.10 CDI82026.1 - 0.21 11.8 14.8 0.2 11.8 8.8 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF4208 PF13907.6 CDI82026.1 - 1.5 9.3 6.0 1.7 9.1 2.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4208) Brr6_like_C_C PF10104.9 CDI82026.1 - 2.2 8.1 5.6 13 5.6 0.1 2.1 1 1 1 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain PTPlike_phytase PF14566.6 CDI82026.1 - 2.5 8.2 9.2 1.9 8.6 7.2 1.7 1 1 1 2 2 2 0 Inositol hexakisphosphate APH PF01636.23 CDI82026.1 - 2.7 7.8 6.8 3.3 7.6 6.5 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family CorA PF01544.18 CDI82026.1 - 4.2 6.6 9.0 1.2 8.4 2.1 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein CR6_interact PF10147.9 CDI82026.1 - 4.2 7.0 16.5 0.15 11.8 9.5 1.8 1 1 1 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 FlgN PF05130.12 CDI82026.1 - 6.8 7.2 25.9 0.55 10.7 18.8 2.0 1 1 1 2 2 2 0 FlgN protein SDA1 PF05285.12 CDI82028.1 - 0.35 10.3 34.6 0.56 9.6 34.6 1.2 1 0 0 1 1 1 0 SDA1 Spc7_N PF15402.6 CDI82028.1 - 0.48 8.6 33.1 0.78 7.9 33.1 1.3 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Pinin_SDK_memA PF04696.13 CDI82030.1 - 0.00011 22.3 0.4 0.00011 22.3 0.4 2.0 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region Pre-PUA PF17832.1 CDI82032.1 - 1.8e-14 54.2 0.2 2.7e-14 53.6 0.2 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CDI82032.1 - 6.1e-06 26.1 0.0 1.3e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 PUA domain Oxidored_q3 PF00499.20 CDI82035.1 - 0.085 12.6 0.9 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 RR_TM4-6 PF06459.12 CDI82035.1 - 1.3 8.8 5.8 2 8.2 5.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2207 PF09972.9 CDI82035.1 - 1.3 7.7 0.0 1.3 7.7 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Suf PF05843.14 CDI82035.1 - 1.7 8.6 9.5 3.3 7.6 9.5 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Orf78 PF06024.12 CDI82035.1 - 2.1 8.7 3.2 76 3.7 0.0 2.4 2 1 0 2 2 2 0 Orf78 (ac78) TMEM43 PF07787.12 CDI82036.1 - 0.082 12.3 0.0 2.6 7.4 0.0 2.2 1 1 1 2 2 2 0 Transmembrane protein 43 Fig1 PF12351.8 CDI82036.1 - 0.57 10.1 2.4 1 9.3 2.4 1.4 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 FGAR-AT_N PF18076.1 CDI82037.1 - 0.0086 16.0 0.5 0.0086 16.0 0.5 2.6 3 0 0 3 3 3 1 Formylglycinamide ribonucleotide amidotransferase N-terminal Late_protein_L1 PF00500.18 CDI82037.1 - 0.024 13.5 0.3 0.033 13.0 0.3 1.3 1 0 0 1 1 1 0 L1 (late) protein tRNA-synt_1c PF00749.21 CDI82037.1 - 0.028 13.3 1.4 0.073 12.0 0.5 2.1 1 1 1 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF711 PF05167.12 CDI82037.1 - 0.14 11.0 0.4 0.18 10.6 0.1 1.5 1 1 0 1 1 1 0 Uncharacterised ACR (DUF711) DUF3371 PF11851.8 CDI82037.1 - 1.5 10.0 10.8 4.5 8.4 4.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) Abhydrolase_6 PF12697.7 CDI82040.1 - 2.8e-11 44.4 0.0 1.8e-09 38.5 0.0 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDI82040.1 - 6.7e-09 35.8 0.0 0.00018 21.2 0.0 3.8 2 1 2 4 4 4 2 alpha/beta hydrolase fold DUF755 PF05501.11 CDI82040.1 - 0.006 16.9 15.2 0.006 16.9 15.2 6.9 6 1 0 6 6 6 1 Domain of unknown function (DUF755) SR-25 PF10500.9 CDI82040.1 - 0.013 15.1 8.1 0.013 15.1 8.1 6.4 6 1 0 6 6 6 0 Nuclear RNA-splicing-associated protein Abhydrolase_4 PF08386.10 CDI82040.1 - 0.013 15.6 0.0 0.047 13.8 0.0 1.9 1 0 0 1 1 1 0 TAP-like protein PAF-AH_p_II PF03403.13 CDI82040.1 - 0.2 10.1 0.0 0.2 10.1 0.0 2.0 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF1178 PF06676.11 CDI82040.1 - 2.7 8.4 13.2 0.77 10.1 2.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) DUF702 PF05142.12 CDI82040.1 - 3.1 8.3 12.4 9.7 6.7 1.9 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Oxysterol_BP PF01237.18 CDI82041.1 - 3.9e-64 216.8 0.0 1e-49 169.4 0.0 5.4 4 1 2 6 6 6 3 Oxysterol-binding protein PH PF00169.29 CDI82041.1 - 1e-11 45.3 0.2 2e-11 44.3 0.2 1.5 1 0 0 1 1 1 1 PH domain Prp19 PF08606.11 CDI82041.1 - 0.028 14.4 6.2 0.23 11.5 6.2 2.7 1 0 0 1 1 1 0 Prp19/Pso4-like TPH PF13868.6 CDI82046.1 - 2.6 6.5 85.2 0.016 13.7 71.4 2.2 2 0 0 2 2 2 0 Trichohyalin-plectin-homology domain Hamartin PF04388.12 CDI82046.1 - 5.1 5.6 43.9 6.4 5.3 43.9 1.1 1 0 0 1 1 1 0 Hamartin protein RNA_pol_Rpb1_5 PF04998.17 CDI82047.1 - 4.3e-17 62.4 0.1 4.8e-17 62.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Asparaginase_2 PF01112.18 CDI82047.1 - 0.0023 17.0 0.1 0.0026 16.9 0.1 1.1 1 0 0 1 1 1 1 Asparaginase SUIM_assoc PF16619.5 CDI82047.1 - 0.009 16.1 4.7 0.014 15.4 4.7 1.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 RAB3GAP2_N PF14655.6 CDI82047.1 - 0.021 14.1 0.4 0.023 14.0 0.4 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF2938 PF11158.8 CDI82047.1 - 0.16 11.4 0.1 0.7 9.3 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2938) AMP-binding PF00501.28 CDI82048.1 - 9.6e-18 64.0 0.0 3.2e-17 62.3 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme PI31_Prot_C PF08577.11 CDI82048.1 - 0.66 11.2 3.1 1.5 10.0 0.1 2.4 2 0 0 2 2 2 0 PI31 proteasome regulator DUF1266 PF06889.11 CDI82048.1 - 1.5 8.8 5.7 0.33 11.0 1.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) DEAD PF00270.29 CDI82050.1 - 7.1e-24 84.5 0.2 3.8e-17 62.6 0.1 2.3 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI82050.1 - 5.3e-05 23.5 0.1 0.0056 17.0 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 CDI82050.1 - 0.0061 15.9 0.4 0.2 11.0 0.1 2.2 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Ntox3 PF15536.6 CDI82050.1 - 0.066 13.2 0.7 5.4 7.1 0.0 2.3 1 1 1 2 2 2 0 Bacterial toxin 3 SR-25 PF10500.9 CDI82050.1 - 0.14 11.7 7.9 0.21 11.2 7.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_22 PF13401.6 CDI82050.1 - 0.28 11.4 3.6 0.3 11.4 0.5 2.2 1 1 0 2 2 2 0 AAA domain Sigma70_ner PF04546.13 CDI82050.1 - 5.2 6.9 11.4 47 3.8 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region AAA_23 PF13476.6 CDI82055.1 - 0.016 15.7 0.5 0.016 15.7 0.5 3.6 3 1 0 3 3 3 0 AAA domain HBS1_N PF08938.10 CDI82055.1 - 0.24 11.7 6.1 0.95 9.8 0.6 2.9 2 1 0 2 2 2 0 HBS1 N-terminus Med15 PF09606.10 CDI82055.1 - 0.5 9.0 43.9 0.17 10.6 10.6 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal T2SSE PF00437.20 CDI82057.1 - 4.7e-05 22.6 0.0 7.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 CDI82057.1 - 0.0045 16.5 0.0 0.0073 15.8 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 CDI82057.1 - 0.005 17.1 0.0 0.0095 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDI82057.1 - 0.019 15.3 2.3 0.027 14.9 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 CDI82057.1 - 0.044 14.1 0.1 0.11 12.8 0.1 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDI82057.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TrwB_AAD_bind PF10412.9 CDI82057.1 - 0.13 11.1 0.4 0.21 10.4 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain SPX PF03105.19 CDI82057.1 - 7.9 6.3 10.8 11 5.8 10.8 1.2 1 0 0 1 1 1 0 SPX domain BAF1_ABF1 PF04684.13 CDI82057.1 - 8.6 5.3 9.1 14 4.6 9.1 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF812 PF05667.11 CDI82061.1 - 0.83 8.5 34.9 1 8.2 34.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2244 PF10003.9 CDI82061.1 - 2.2 7.9 5.3 6 6.5 2.6 2.4 1 1 1 2 2 2 0 Integral membrane protein (DUF2244) AAA_9 PF12781.7 CDI82066.1 - 2e-77 259.2 0.6 3.2e-77 258.6 0.6 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region GARP PF16731.5 CDI82066.1 - 0.0065 16.2 2.6 0.18 11.4 0.2 2.1 1 1 0 2 2 2 2 Glutamic acid/alanine-rich protein of Trypanosoma APG6_N PF17675.1 CDI82066.1 - 0.009 16.5 7.0 0.2 12.2 2.7 2.2 2 0 0 2 2 2 2 Apg6 coiled-coil region FapA PF03961.13 CDI82066.1 - 0.44 9.1 3.2 0.68 8.5 3.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LUC7 PF03194.15 CDI82070.1 - 5.5e-15 55.7 0.0 5.5e-15 55.7 0.0 3.9 3 1 0 4 4 4 1 LUC7 N_terminus DUF4080 PF13311.6 CDI82070.1 - 0.012 15.8 16.5 0.42 10.8 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) N-glycanase_N PF09112.10 CDI82070.1 - 0.053 13.3 5.5 2.4 7.9 0.5 2.2 2 0 0 2 2 2 0 Peptide-N-glycosidase F, N terminal Spore_YhcN_YlaJ PF09580.10 CDI82070.1 - 0.53 10.4 22.3 0.16 12.1 4.1 3.1 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Topoisom_I_N PF02919.15 CDI82070.1 - 3.3 7.2 14.8 5.4 6.5 3.3 2.4 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Lipid_DES PF08557.10 CDI82073.1 - 2e-11 43.2 0.1 3e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) RskA PF10099.9 CDI82073.1 - 0.00029 21.2 15.5 0.0064 16.8 0.0 2.8 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI82073.1 - 0.0032 17.1 11.5 0.0032 17.1 11.5 2.6 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDI82073.1 - 0.012 16.3 4.1 0.012 16.3 4.1 3.2 2 1 1 3 3 3 0 Immortalisation up-regulated protein DUF3446 PF11928.8 CDI82073.1 - 0.019 15.2 4.3 0.019 15.2 4.3 3.6 2 1 1 3 3 3 0 Early growth response N-terminal domain CLN3 PF02487.17 CDI82073.1 - 0.24 10.4 2.3 0.41 9.6 2.3 1.3 1 0 0 1 1 1 0 CLN3 protein CCSAP PF15748.5 CDI82073.1 - 5.6 7.1 20.1 3.6 7.7 10.4 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF3449 PF11931.8 CDI82074.1 - 5.1e-16 59.0 0.1 5.5e-16 58.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) CT47 PF15623.6 CDI82075.1 - 1.2 8.9 19.0 1.5 8.6 19.0 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 Ubiq_cyt_C_chap PF03981.12 CDI82076.1 - 3.5e-06 27.2 0.0 8.1e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone SOBP PF15279.6 CDI82076.1 - 0.92 10.1 5.9 1.1 9.8 5.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SR-25 PF10500.9 CDI82076.1 - 2.7 7.5 21.1 7.3 6.1 13.4 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CDI82076.1 - 8.3 3.4 8.9 10 3.1 8.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI82077.1 - 0.16 10.5 5.6 0.24 9.9 5.6 1.3 1 0 0 1 1 1 0 Macoilin family FlaG PF03646.15 CDI82078.1 - 0.19 11.9 0.0 0.29 11.3 0.0 1.2 1 0 0 1 1 1 0 FlaG protein SET PF00856.28 CDI82080.1 - 0.0082 16.5 0.0 0.06 13.7 0.0 2.5 1 1 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 CDI82080.1 - 0.09 13.5 0.5 0.33 11.6 0.1 2.2 2 0 0 2 2 2 0 Rubisco LSMT substrate-binding DUF572 PF04502.13 CDI82083.1 - 0.013 15.1 15.3 0.017 14.7 15.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) WD40 PF00400.32 CDI82083.1 - 0.027 15.3 0.0 0.054 14.4 0.0 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat APC_basic PF05956.11 CDI82083.1 - 0.027 13.9 12.9 0.036 13.5 12.9 1.1 1 0 0 1 1 1 0 APC basic domain FAM60A PF15396.6 CDI82083.1 - 0.061 13.3 14.0 0.088 12.8 14.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 CDI82083.1 - 0.49 8.6 17.9 0.59 8.4 17.9 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 CDI82083.1 - 0.88 8.5 20.0 1.4 7.8 20.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Latrophilin PF02354.16 CDI82083.1 - 1.3 8.0 16.3 1.8 7.5 16.3 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region SPT6_acidic PF14632.6 CDI82083.1 - 2.5 8.7 22.0 0.11 13.1 5.4 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Suf PF05843.14 CDI82083.1 - 2.8 7.9 25.2 4.7 7.1 25.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF5308 PF17233.2 CDI82083.1 - 3.1 8.0 20.6 2.5 8.3 10.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5308) FUSC PF04632.12 CDI82083.1 - 5.3 5.4 15.2 6.4 5.2 15.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Presenilin PF01080.17 CDI82083.1 - 8.1 5.1 24.4 12 4.6 24.4 1.2 1 0 0 1 1 1 0 Presenilin Smg8_Smg9 PF10220.9 CDI82083.1 - 8.6 4.5 23.0 13 3.9 23.0 1.2 1 0 0 1 1 1 0 Smg8_Smg9 PNISR PF15996.5 CDI82083.1 - 9.3 6.5 29.0 18 5.6 29.0 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF2722 PF10846.8 CDI82084.1 - 0.00023 20.2 1.0 0.00095 18.2 3.4 13.5 8 3 4 14 14 14 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI82084.1 - 0.00071 19.3 20.3 0.0011 18.6 3.2 13.7 13 1 0 13 13 13 5 Spt20 family Pkinase PF00069.25 CDI82085.1 - 3.1e-20 72.7 0.0 3.1e-20 72.7 0.0 4.0 5 0 0 5 5 5 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82085.1 - 6.1e-17 61.8 0.5 8.2e-15 54.8 0.5 3.5 1 1 0 1 1 1 1 Protein tyrosine kinase Tim29 PF10171.9 CDI82085.1 - 7 6.1 6.5 1.8 8.1 1.6 2.6 3 0 0 3 3 3 0 Translocase of the Inner Mitochondrial membrane 29 Pkinase PF00069.25 CDI82086.1 - 9.5e-61 205.5 0.0 1.4e-60 204.9 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82086.1 - 4.1e-32 111.5 0.0 4.9e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI82086.1 - 8.1e-07 28.6 0.0 1.7e-06 27.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDI82086.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family EF-hand_1 PF00036.32 CDI82090.1 - 1.1e-26 90.3 6.8 5.8e-07 28.6 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 CDI82090.1 - 5.9e-23 79.3 7.0 1.7e-05 24.1 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CDI82090.1 - 2.3e-22 77.0 2.7 1.2e-05 24.8 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 CDI82090.1 - 1e-21 77.2 3.9 5e-11 42.9 0.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDI82090.1 - 1.1e-09 38.0 10.1 0.00062 19.6 0.2 3.9 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 CDI82090.1 - 1.9e-07 30.9 1.2 8e-05 22.5 0.1 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDI82090.1 - 6.6e-05 23.2 0.4 0.12 12.7 0.0 3.0 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Chorion_2 PF03964.15 CDI82091.1 - 0.41 11.5 5.3 0.99 10.3 5.3 1.6 1 0 0 1 1 1 0 Chorion family 2 Ribosomal_L12_N PF16320.5 CDI82091.1 - 9.6 6.0 14.8 24 4.7 14.8 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain WD40 PF00400.32 CDI82092.1 - 1.8e-09 38.0 10.0 0.021 15.7 0.3 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI82092.1 - 0.0028 17.9 0.0 14 6.1 0.0 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain MPS2 PF17060.5 CDI82092.1 - 0.02 14.2 7.7 0.035 13.4 7.7 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 GRIM-19 PF06212.12 CDI82092.1 - 0.035 14.0 3.6 0.089 12.7 3.6 1.6 1 0 0 1 1 1 0 GRIM-19 protein FAM76 PF16046.5 CDI82092.1 - 0.23 10.8 10.2 0.4 10.0 10.2 1.4 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 CDI82092.1 - 2.3 7.2 16.3 4.3 6.3 16.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 THRAP3_BCLAF1 PF15440.6 CDI82093.1 - 1.5 7.8 5.6 2.1 7.3 5.6 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family VPS13_C PF16909.5 CDI82094.1 - 3.4e-23 82.3 0.4 3e-19 69.5 0.0 2.7 2 1 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 CDI82094.1 - 1.6e-05 24.8 0.0 0.00044 20.1 0.0 2.4 1 1 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal ATG_C PF09333.11 CDI82094.1 - 6.3e-05 23.3 0.0 0.00023 21.5 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 CDI82094.1 - 0.025 14.7 0.1 0.14 12.3 0.1 2.3 1 1 0 1 1 1 0 N-terminal region of Chorein or VPS13 Glyco_transf_22 PF03901.17 CDI82094.1 - 0.23 10.6 0.1 0.37 10.0 0.1 1.2 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family HhH-GPD PF00730.25 CDI82095.1 - 2e-10 41.1 0.0 4.1e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDI82095.1 - 5.3e-05 22.9 0.3 0.042 13.7 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_2 PF12826.7 CDI82095.1 - 0.003 17.6 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.6 CDI82095.1 - 0.0036 17.9 0.0 5 7.8 0.0 2.4 2 1 0 2 2 2 2 Helix-hairpin-helix domain AF-4 PF05110.13 CDI82095.1 - 0.029 12.5 49.4 0.04 12.0 49.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Spt20 PF12090.8 CDI82095.1 - 0.31 10.6 86.4 0.046 13.3 48.4 2.3 1 1 1 2 2 2 0 Spt20 family CDC45 PF02724.14 CDI82095.1 - 0.87 7.8 34.8 1.4 7.1 34.8 1.3 1 0 0 1 1 1 0 CDC45-like protein XRN_M PF17846.1 CDI82095.1 - 5.8 5.7 26.0 8.8 5.2 26.0 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Lon_C PF05362.13 CDI82097.1 - 3.5e-07 30.0 0.1 5.2e-07 29.4 0.0 1.3 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain Apt1 PF10351.9 CDI82098.1 - 2.5 6.9 6.8 2.4 6.9 6.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SUIM_assoc PF16619.5 CDI82099.1 - 0.04 14.0 6.7 0.04 14.0 6.7 2.7 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Exonuc_VII_L PF02601.15 CDI82099.1 - 0.18 11.4 18.6 0.23 11.0 18.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Asp_Glu_race PF01177.22 CDI82099.1 - 0.63 9.9 8.9 0.53 10.1 4.2 2.1 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase RskA PF10099.9 CDI82099.1 - 1.7 8.9 11.6 0.043 14.1 2.9 2.0 1 1 1 2 2 2 0 Anti-sigma-K factor rskA FapA PF03961.13 CDI82099.1 - 2.2 6.8 13.3 0.049 12.2 5.3 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A PAT1 PF09770.9 CDI82101.1 - 0.22 9.8 26.7 0.25 9.6 26.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 CDI82101.1 - 0.42 7.7 21.6 0.48 7.5 21.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LD_cluster2 PF18163.1 CDI82101.1 - 0.42 10.1 8.9 0.79 9.2 8.9 1.4 1 0 0 1 1 1 0 SLOG cluster2 DUF1387 PF07139.11 CDI82101.1 - 0.62 9.7 20.0 0.71 9.6 20.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) CAC1F_C PF16885.5 CDI82101.1 - 2.4 7.7 16.6 3 7.4 16.6 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SARAF PF06682.12 CDI82101.1 - 3 7.4 20.0 4.9 6.7 20.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Ndc1_Nup PF09531.10 CDI82101.1 - 5.9 5.5 19.3 6.8 5.3 19.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF572 PF04502.13 CDI82101.1 - 6.3 6.3 22.1 8.8 5.8 22.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Trp_oprn_chp PF09534.10 CDI82103.1 - 5.2e-05 23.1 11.5 0.00012 21.9 4.5 2.2 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CRAL_TRIO_2 PF13716.6 CDI82103.1 - 0.0017 18.5 0.0 0.0031 17.7 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SPX PF03105.19 CDI82103.1 - 0.0037 17.2 18.8 0.0052 16.7 18.8 1.2 1 0 0 1 1 1 1 SPX domain RAP1 PF07218.11 CDI82103.1 - 0.059 11.7 15.7 0.075 11.3 15.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SID-1_RNA_chan PF13965.6 CDI82103.1 - 0.46 8.8 10.6 0.37 9.2 9.1 1.5 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.10 CDI82103.1 - 0.56 10.3 13.1 0.029 14.4 6.7 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal O-antigen_lig PF13425.6 CDI82103.1 - 0.76 8.5 4.6 0.15 10.8 0.6 1.7 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Peptidase_M56 PF05569.11 CDI82103.1 - 1 8.5 3.1 2.2 7.4 3.1 1.6 1 0 0 1 1 1 0 BlaR1 peptidase M56 Hamartin PF04388.12 CDI82103.1 - 1.2 7.7 21.6 1.5 7.4 21.6 1.1 1 0 0 1 1 1 0 Hamartin protein NST1 PF13945.6 CDI82103.1 - 4.5 7.3 31.5 6.2 6.9 13.4 2.4 2 1 0 2 2 2 0 Salt tolerance down-regulator CBM9_2 PF16011.5 CDI82107.1 - 0.091 12.5 0.2 0.1 12.3 0.2 1.1 1 0 0 1 1 1 0 Carbohydrate-binding family 9 ELFV_dehydrog PF00208.21 CDI82109.1 - 5.8e-17 62.2 0.0 1.1e-16 61.4 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 CDI82109.1 - 1.4e-09 36.2 0.0 1.9e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial NAD-glutamate dehydrogenase eRF1_2 PF03464.15 CDI82110.1 - 2.9e-43 147.4 0.1 5.3e-43 146.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CDI82110.1 - 2.1e-36 124.8 0.5 3.6e-36 124.1 0.5 1.4 1 0 0 1 1 1 1 eRF1 domain 3 acVLRF1 PF18859.1 CDI82110.1 - 2.5e-09 37.5 0.1 5.5e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 CDI82110.1 - 7.9e-06 26.2 0.0 1.5e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Ssl1 PF04056.14 CDI82110.1 - 0.075 12.8 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Ssl1-like Pkinase PF00069.25 CDI82111.1 - 4.5e-21 75.4 0.0 9.7e-21 74.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain EF-hand_1 PF00036.32 CDI82111.1 - 4.2e-16 57.2 0.5 0.00022 20.5 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDI82111.1 - 7.6e-16 56.6 0.1 0.00019 21.1 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 CDI82111.1 - 8e-16 58.3 1.3 1e-07 32.2 0.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDI82111.1 - 1.5e-08 34.3 0.6 0.011 15.5 0.0 3.6 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 CDI82111.1 - 9e-06 25.0 5.1 0.0072 15.8 0.0 3.8 4 0 0 4 4 4 2 EF hand Pkinase_Tyr PF07714.17 CDI82111.1 - 4.3e-05 22.9 0.0 6.9e-05 22.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase SPARC_Ca_bdg PF10591.9 CDI82111.1 - 0.00014 22.2 0.1 0.6 10.5 0.0 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDI82111.1 - 0.002 18.4 0.1 0.69 10.3 0.0 3.8 4 0 0 4 4 4 1 EF-hand domain RNase_PH PF01138.21 CDI82112.1 - 1.1e-16 61.5 0.1 1.2e-15 58.2 0.1 2.2 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 tRNA_edit PF04073.15 CDI82115.1 - 1.3e-06 28.5 0.0 3.1e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain DUF4349 PF14257.6 CDI82116.1 - 0.00023 20.7 2.4 0.00042 19.8 2.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) Acid_PPase PF12689.7 CDI82116.1 - 0.082 12.8 0.1 0.29 11.0 0.2 1.7 2 0 0 2 2 2 0 Acid Phosphatase HC2 PF07382.11 CDI82118.1 - 9.9e-06 25.8 2.9 1.1e-05 25.6 2.9 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Nuc_rec_co-act PF08815.10 CDI82118.1 - 0.13 12.2 4.9 5.9 6.8 0.4 2.5 2 0 0 2 2 2 0 Nuclear receptor coactivator DUF424 PF04242.13 CDI82118.1 - 0.14 12.4 4.5 1.6 9.0 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF424) Spt20 PF12090.8 CDI82120.1 - 0.0013 18.4 27.5 0.0023 17.6 13.6 2.2 2 0 0 2 2 2 2 Spt20 family DUF4820 PF16091.5 CDI82120.1 - 0.088 12.2 8.2 0.029 13.8 4.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) AP3D1 PF06375.11 CDI82120.1 - 0.65 10.2 14.7 0.11 12.8 8.9 2.2 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 Neur_chan_memb PF02932.16 CDI82120.1 - 2.4 8.2 8.7 4.4 7.3 8.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SR-25 PF10500.9 CDI82120.1 - 3 7.4 25.4 0.45 10.1 4.1 2.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Med19 PF10278.9 CDI82120.1 - 4.3 7.2 14.9 3.5 7.5 9.7 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 PAN_4 PF14295.6 CDI82121.1 - 2.1e-13 50.0 4.4 4.4e-06 26.5 0.2 2.6 2 0 0 2 2 2 2 PAN domain SUIM_assoc PF16619.5 CDI82121.1 - 0.013 15.5 3.2 0.013 15.5 3.2 23.9 10 5 4 14 14 14 0 Unstructured region C-term to UIM in Ataxin3 FadA PF09403.10 CDI82122.1 - 0.00025 21.4 5.4 0.00025 21.4 5.4 2.8 1 1 1 2 2 2 1 Adhesion protein FadA RskA PF10099.9 CDI82123.1 - 0.0012 19.1 20.5 0.0012 19.1 20.5 5.2 1 1 2 3 3 3 1 Anti-sigma-K factor rskA TetR_C_23 PF17931.1 CDI82123.1 - 0.35 11.0 2.3 1.2 9.3 2.3 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RT_RNaseH_2 PF17919.1 CDI82124.1 - 1.2e-22 79.8 0.0 2.3e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI82124.1 - 2e-21 76.3 0.0 3.8e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVP_2 PF08284.11 CDI82124.1 - 1.4e-09 37.8 0.0 2.6e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 CDI82124.1 - 2.8e-08 34.3 0.0 7.2e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI82124.1 - 2.8e-07 31.0 0.0 5.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 CDI82124.1 - 0.0011 18.6 0.0 0.0082 15.7 0.0 2.1 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease PF09668.10 CDI82124.1 - 0.0045 16.8 0.0 0.0083 15.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDI82124.1 - 0.02 15.2 0.0 0.057 13.7 0.0 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease rve PF00665.26 CDI82124.1 - 0.089 13.0 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Integrase core domain DUF1758 PF05585.12 CDI82124.1 - 0.14 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Spt20 PF12090.8 CDI82126.1 - 0.7 9.5 25.1 0.95 9.0 25.1 1.2 1 0 0 1 1 1 0 Spt20 family MMR1 PF08505.10 CDI82126.1 - 0.82 9.9 11.6 0.94 9.7 11.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Lin-8 PF03353.15 CDI82126.1 - 1.4 8.4 11.1 1.6 8.2 11.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Draxin PF15550.6 CDI82126.1 - 1.7 8.4 7.5 2 8.2 7.5 1.1 1 0 0 1 1 1 0 Draxin TERB2 PF15101.6 CDI82126.1 - 2.1 8.4 10.1 2.6 8.1 10.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Miga PF10265.9 CDI82126.1 - 4.1 6.3 9.1 4.7 6.1 9.1 1.1 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 CDI82126.1 - 6.5 5.4 9.9 7.1 5.3 9.9 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CDI82126.1 - 7.7 4.5 10.0 8.3 4.4 10.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PCM1_C PF15717.5 CDI82126.1 - 7.9 5.0 12.9 9.1 4.8 12.9 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus EPL1 PF10513.9 CDI82128.1 - 0.27 11.6 36.6 1.6 9.1 16.0 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like ALMT PF11744.8 CDI82128.1 - 0.31 9.8 35.2 0.41 9.4 11.0 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF3807 PF12720.7 CDI82128.1 - 0.34 11.2 43.8 0.055 13.7 14.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) MMR1 PF08505.10 CDI82128.1 - 0.37 11.1 40.7 1.5 9.0 16.6 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Presenilin PF01080.17 CDI82128.1 - 0.44 9.2 41.7 0.12 11.1 16.1 2.0 2 0 0 2 2 2 0 Presenilin FYDLN_acid PF09538.10 CDI82128.1 - 0.51 11.0 25.4 3.2 8.5 7.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) CCSAP PF15748.5 CDI82128.1 - 0.57 10.3 39.8 0.15 12.2 14.2 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated RXT2_N PF08595.11 CDI82128.1 - 0.63 10.1 27.8 0.28 11.2 8.5 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM76 PF16046.5 CDI82128.1 - 0.71 9.2 33.7 0.47 9.7 13.5 2.3 2 0 0 2 2 2 0 FAM76 protein RR_TM4-6 PF06459.12 CDI82128.1 - 1 9.1 41.7 0.75 9.6 17.1 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RPN2_C PF18004.1 CDI82128.1 - 1 9.2 36.2 0.35 10.8 14.9 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain eIF-3_zeta PF05091.12 CDI82128.1 - 1.3 8.0 42.4 0.052 12.5 14.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SLC12 PF03522.15 CDI82128.1 - 1.6 7.7 39.1 0.12 11.4 12.7 2.0 2 0 0 2 2 2 0 Solute carrier family 12 CPSF100_C PF13299.6 CDI82128.1 - 1.9 8.7 34.3 0.94 9.6 12.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pex14_N PF04695.13 CDI82128.1 - 2.2 8.9 56.4 0.97 10.1 24.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Dynamin_N PF00350.23 CDI82128.1 - 2.2 8.3 16.9 3.7 7.6 5.1 2.4 2 0 0 2 2 2 0 Dynamin family Ureide_permease PF07168.11 CDI82128.1 - 2.4 6.8 22.7 0.028 13.2 4.7 2.1 2 0 0 2 2 2 0 Ureide permease DUF4820 PF16091.5 CDI82128.1 - 2.6 7.4 33.0 2.4 7.4 12.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF4045 PF13254.6 CDI82128.1 - 2.6 7.6 35.7 0.61 9.7 13.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) SpoIIP PF07454.11 CDI82128.1 - 2.6 7.4 41.1 0.74 9.2 16.7 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF702 PF05142.12 CDI82128.1 - 2.7 8.4 29.1 0.38 11.2 9.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DUF5427 PF10310.9 CDI82128.1 - 3.5 6.5 44.9 0.8 8.6 15.5 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Hamartin PF04388.12 CDI82128.1 - 3.6 6.1 37.6 5.1 5.6 37.6 1.2 1 0 0 1 1 1 0 Hamartin protein DUF2151 PF10221.9 CDI82128.1 - 4.1 5.9 22.7 2.4 6.7 7.8 2.0 2 0 0 2 2 2 0 Cell cycle and development regulator DUF5523 PF17661.1 CDI82128.1 - 4.5 6.9 42.9 2.3 7.9 15.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) SMYLE_N PF18615.1 CDI82128.1 - 4.9 6.6 27.1 0.49 9.9 8.6 2.1 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Nop53 PF07767.11 CDI82128.1 - 5.2 6.3 52.5 1.4 8.3 19.8 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Endostatin PF06482.11 CDI82128.1 - 6 6.2 34.0 0.96 8.8 11.5 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Vfa1 PF08432.10 CDI82128.1 - 7.7 6.8 41.7 3.8 7.8 15.5 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 FAM176 PF14851.6 CDI82128.1 - 7.8 6.2 31.7 0.83 9.3 10.9 2.3 2 0 0 2 2 2 0 FAM176 family AAA_11 PF13086.6 CDI82128.1 - 8.2 6.1 41.6 0.89 9.3 12.7 2.1 2 0 0 2 2 2 0 AAA domain Neur_chan_memb PF02932.16 CDI82128.1 - 8.4 6.4 32.4 0.9 9.5 9.8 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region LAP1C PF05609.12 CDI82128.1 - 8.5 5.3 40.0 0.15 11.2 13.1 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) DUF3474 PF11960.8 CDI82128.1 - 8.8 6.5 12.8 5 7.3 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) DUF1943 PF09172.11 CDI82128.1 - 8.9 5.4 22.7 0.54 9.4 2.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) DUF3449 PF11931.8 CDI82128.1 - 9.2 6.0 30.3 7.3 6.3 9.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) KR PF08659.10 CDI82131.1 - 2.4e-51 174.2 0.0 7e-51 172.7 0.0 1.8 1 1 0 1 1 1 1 KR domain PS-DH PF14765.6 CDI82131.1 - 6.9e-41 140.4 0.3 2.6e-40 138.5 0.3 1.9 1 1 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 CDI82131.1 - 1.8e-13 50.6 0.2 3.7e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CDI82131.1 - 2.3e-10 40.2 0.0 5e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDI82131.1 - 1.7e-07 31.0 0.0 4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 5_3_exonuc_N PF02739.16 CDI82134.1 - 4.5e-32 111.2 0.0 4.3e-29 101.5 0.0 2.1 2 0 0 2 2 2 2 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 CDI82134.1 - 1.1e-09 38.7 0.1 3.7e-09 37.1 0.0 1.9 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold SUIM_assoc PF16619.5 CDI82134.1 - 0.029 14.4 5.5 0.071 13.2 5.4 1.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI82134.1 - 0.032 13.9 3.3 0.044 13.4 3.3 1.2 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI82134.1 - 8.4 5.5 8.0 12 5.0 8.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CPT PF07931.12 CDI82135.1 - 1.4 8.7 5.7 13 5.6 0.2 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Kei1 PF08552.11 CDI82135.1 - 5.4 6.8 16.2 1.2 9.0 0.3 3.2 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 PAP_assoc PF03828.19 CDI82137.1 - 4.9e-09 36.3 0.0 1.5e-08 34.7 0.0 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDI82137.1 - 0.00062 20.0 0.0 0.033 14.5 0.0 2.6 2 0 0 2 2 2 1 Nucleotidyltransferase domain Patched PF02460.18 CDI82138.1 - 6.2e-92 309.1 18.5 4.7e-56 190.4 0.0 2.8 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 CDI82138.1 - 1.2e-29 103.1 7.2 1.2e-29 103.1 7.2 2.2 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation IZUMO PF15005.6 CDI82138.1 - 0.82 10.2 2.5 3.1 8.3 0.3 2.2 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated MORN PF02493.20 CDI82139.1 - 2.1e-18 65.0 17.1 3.9e-06 26.4 0.0 4.8 4 0 0 4 4 4 4 MORN repeat CRAL_TRIO_2 PF13716.6 CDI82140.1 - 0.0048 17.1 0.1 0.0088 16.2 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain MoaF PF10703.9 CDI82140.1 - 0.066 13.2 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 MoaF N-terminal domain Ribosomal_60s PF00428.19 CDI82140.1 - 0.67 10.6 18.1 0.1 13.2 13.0 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein HAGH_C PF16123.5 CDI82141.1 - 5.2e-28 97.4 0.1 8.2e-28 96.7 0.1 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CDI82141.1 - 3.2e-08 33.8 0.3 6.5e-08 32.8 0.1 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily SH PF01445.17 CDI82141.1 - 0.098 12.6 0.9 0.17 11.9 0.9 1.4 1 0 0 1 1 1 0 Viral small hydrophobic protein UPF0139 PF03669.13 CDI82142.1 - 3.3e-07 30.1 0.2 4e-07 29.8 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Mito_carr PF00153.27 CDI82143.1 - 4.6e-55 183.5 7.2 2.5e-20 72.2 0.0 4.9 3 2 0 3 3 3 3 Mitochondrial carrier protein HCV_NS5a_1a PF08300.13 CDI82143.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a zinc finger domain zf-CCCH PF00642.24 CDI82146.1 - 6.5e-08 32.3 18.8 0.00013 21.8 0.8 3.5 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 CDI82146.1 - 7.7e-05 22.9 15.3 0.0014 18.8 3.3 3.2 2 1 1 3 3 3 2 Zinc-finger containing family zf-C3H1 PF10650.9 CDI82146.1 - 0.0027 17.4 3.0 0.14 11.9 1.7 2.6 2 0 0 2 2 2 1 Putative zinc-finger domain Torus PF16131.5 CDI82146.1 - 0.0029 18.3 27.4 0.84 10.4 4.1 4.4 1 1 2 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 CDI82146.1 - 0.026 15.0 0.9 0.026 15.0 0.9 3.5 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDI82146.1 - 0.027 14.3 23.6 0.054 13.3 5.7 4.1 3 1 0 3 3 3 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CDI82146.1 - 0.078 13.1 26.7 0.25 11.5 0.3 4.3 3 1 0 3 3 3 0 Zinc finger domain Spt20 PF12090.8 CDI82146.1 - 0.26 10.8 10.1 0.49 10.0 10.1 1.3 1 0 0 1 1 1 0 Spt20 family RskA PF10099.9 CDI82146.1 - 5.2 7.3 44.5 0.071 13.4 1.1 4.4 3 1 0 3 3 3 0 Anti-sigma-K factor rskA DUF1664 PF07889.12 CDI82147.1 - 0.0059 16.6 4.6 0.0059 16.6 4.6 9.2 5 3 7 12 12 12 5 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 CDI82147.1 - 0.0082 16.2 27.6 0.0082 16.2 27.6 10.6 4 3 6 10 10 10 2 TPR/MLP1/MLP2-like protein ZapB PF06005.12 CDI82147.1 - 0.0097 16.3 12.2 0.0097 16.3 12.2 14.8 7 4 6 13 13 13 5 Cell division protein ZapB HALZ PF02183.18 CDI82147.1 - 0.01 16.0 3.2 0.01 16.0 3.2 12.6 16 1 0 16 16 16 0 Homeobox associated leucine zipper DUF3800 PF12686.7 CDI82147.1 - 0.022 15.4 2.6 80 3.9 1.8 5.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) Pkinase PF00069.25 CDI82149.1 - 4.2e-51 173.8 0.0 9.1e-37 126.9 0.0 3.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82149.1 - 1.2e-23 83.7 0.0 1.3e-21 77.0 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase EF-hand_7 PF13499.6 CDI82149.1 - 7.9e-16 58.3 0.3 1.7e-08 34.8 0.2 4.1 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 CDI82149.1 - 3.3e-15 54.4 3.1 0.0066 15.9 0.2 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CDI82149.1 - 1.2e-11 43.5 7.2 0.014 15.3 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDI82149.1 - 9.2e-09 34.4 11.3 0.053 13.0 0.2 5.4 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 CDI82149.1 - 8.2e-07 28.8 5.4 0.76 9.7 0.0 5.0 5 0 0 5 5 5 2 EF-hand domain pair Presenilin PF01080.17 CDI82149.1 - 7.3e-06 25.0 4.8 7.3e-06 25.0 4.8 3.7 4 0 0 4 4 4 1 Presenilin Kinase-like PF14531.6 CDI82149.1 - 0.0016 17.9 0.0 1.3 8.3 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CDI82149.1 - 0.065 12.0 9.0 2 7.1 0.0 2.9 3 1 0 3 3 3 0 Fungal protein kinase DAG_kinase_N PF14513.6 CDI82149.1 - 10 6.3 29.4 0.13 12.5 5.3 4.1 4 1 0 4 4 3 0 Diacylglycerol kinase N-terminus SET PF00856.28 CDI82150.1 - 4.9e-13 49.8 0.0 4.9e-13 49.8 0.0 13.2 10 4 0 10 10 10 1 SET domain Bromodomain PF00439.25 CDI82150.1 - 4.1e-10 39.6 0.0 9.5e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 CDI82150.1 - 8.3e-05 22.4 2.3 8.3e-05 22.4 2.3 9.1 9 1 1 10 10 10 4 PHD-finger FYRN PF05964.14 CDI82150.1 - 0.18 11.7 0.0 0.18 11.7 0.0 2.5 3 0 0 3 3 3 0 F/Y-rich N-terminus ABC_tran PF00005.27 CDI82151.1 - 1.5e-32 113.0 23.5 5.9e-15 56.0 0.1 5.0 4 1 0 4 4 3 3 ABC transporter AAA_21 PF13304.6 CDI82151.1 - 6.3e-28 98.4 0.6 4.2e-06 26.8 0.0 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDI82151.1 - 5.5e-19 68.5 10.0 1.4e-08 34.5 5.2 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDI82151.1 - 4.4e-10 39.1 0.1 0.0017 18.1 0.0 3.1 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CDI82151.1 - 1.9e-07 31.8 1.1 0.00032 21.2 0.0 6.1 2 1 2 5 5 3 2 AAA domain AAA_25 PF13481.6 CDI82151.1 - 1.2e-06 28.2 1.8 0.0042 16.7 0.6 3.4 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 CDI82151.1 - 3.7e-06 27.0 0.0 0.16 12.1 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase NTPase_1 PF03266.15 CDI82151.1 - 9.3e-06 25.7 0.6 0.049 13.5 0.1 2.5 2 0 0 2 2 2 2 NTPase PduV-EutP PF10662.9 CDI82151.1 - 1e-05 25.3 1.8 0.015 15.1 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 CDI82151.1 - 5.1e-05 23.3 2.4 0.19 11.8 0.2 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDI82151.1 - 0.00011 22.6 0.2 0.45 10.9 0.0 2.6 2 0 0 2 2 2 2 RNA helicase MobB PF03205.14 CDI82151.1 - 0.00013 21.8 0.7 0.61 10.0 0.1 3.0 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.29 CDI82151.1 - 0.0002 21.8 7.6 0.11 13.0 0.0 3.8 4 1 1 5 5 3 2 ATPase family associated with various cellular activities (AAA) Arf PF00025.21 CDI82151.1 - 0.00024 20.6 0.4 0.86 9.0 0.1 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_15 PF13175.6 CDI82151.1 - 0.0004 20.2 0.5 0.028 14.1 0.1 4.0 2 2 2 4 4 3 2 AAA ATPase domain IstB_IS21 PF01695.17 CDI82151.1 - 0.00054 19.7 11.9 0.06 13.1 0.1 3.6 4 0 0 4 4 3 2 IstB-like ATP binding protein AAA_18 PF13238.6 CDI82151.1 - 0.00068 20.2 5.7 0.19 12.3 0.0 4.1 4 0 0 4 4 3 1 AAA domain AAA_5 PF07728.14 CDI82151.1 - 0.0007 19.6 1.2 2.7 8.0 0.1 3.6 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) SRP54 PF00448.22 CDI82151.1 - 0.00089 18.9 1.0 0.023 14.3 0.1 4.2 4 0 0 4 4 2 2 SRP54-type protein, GTPase domain cobW PF02492.19 CDI82151.1 - 0.00091 18.9 0.1 0.049 13.2 0.0 3.3 3 0 0 3 3 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 CDI82151.1 - 0.0011 18.5 4.7 0.44 10.0 0.2 2.7 3 0 0 3 3 2 2 P-loop containing dynein motor region ATP_bind_1 PF03029.17 CDI82151.1 - 0.0014 18.4 0.1 0.61 9.8 0.0 2.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CDI82151.1 - 0.0018 18.6 0.0 0.0018 18.6 0.0 5.3 5 1 1 6 6 5 2 AAA domain ABC_tran_Xtn PF12848.7 CDI82151.1 - 0.0018 18.3 1.2 0.0018 18.3 1.2 7.6 6 2 1 7 7 3 1 ABC transporter FeoB_N PF02421.18 CDI82151.1 - 0.0018 17.8 0.6 0.86 9.1 0.1 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_19 PF13245.6 CDI82151.1 - 0.0021 18.4 9.6 0.34 11.2 0.0 3.3 3 1 0 3 3 2 2 AAA domain NACHT PF05729.12 CDI82151.1 - 0.0022 18.0 0.1 0.0022 18.0 0.1 5.1 5 1 0 5 5 3 1 NACHT domain AAA_28 PF13521.6 CDI82151.1 - 0.0023 18.2 0.6 0.0023 18.2 0.6 5.8 6 1 0 6 6 3 1 AAA domain T2SSE PF00437.20 CDI82151.1 - 0.0025 16.9 15.9 0.021 13.9 5.4 3.4 4 1 0 4 4 4 2 Type II/IV secretion system protein Pox_A32 PF04665.12 CDI82151.1 - 0.0026 17.2 0.2 1.6 8.2 0.0 2.7 3 0 0 3 3 3 1 Poxvirus A32 protein RsgA_GTPase PF03193.16 CDI82151.1 - 0.0035 17.3 0.2 0.0035 17.3 0.2 3.2 4 0 0 4 4 2 2 RsgA GTPase Roc PF08477.13 CDI82151.1 - 0.0039 17.4 0.8 0.11 12.7 0.2 4.3 5 0 0 5 5 3 2 Ras of Complex, Roc, domain of DAPkinase Bac_DnaA PF00308.18 CDI82151.1 - 0.0042 17.0 0.0 1.6 8.6 0.0 2.6 2 0 0 2 2 2 1 Bacterial dnaA protein ATP-synt_ab PF00006.25 CDI82151.1 - 0.0042 16.8 2.7 0.11 12.1 0.2 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.18 CDI82151.1 - 0.0045 16.9 0.1 1.5 8.6 0.0 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea G-alpha PF00503.20 CDI82151.1 - 0.0046 16.2 0.8 0.0046 16.2 0.8 3.5 2 2 1 3 3 2 1 G-protein alpha subunit SRPRB PF09439.10 CDI82151.1 - 0.0088 15.5 0.2 0.98 8.8 0.0 2.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 CDI82151.1 - 0.011 15.9 29.8 0.069 13.3 3.5 5.4 4 2 1 5 5 4 0 AAA domain Rad17 PF03215.15 CDI82151.1 - 0.013 15.5 1.4 2.5 8.0 0.0 2.9 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_24 PF13479.6 CDI82151.1 - 0.043 13.5 0.0 0.043 13.5 0.0 3.9 4 1 0 4 4 3 0 AAA domain PRK PF00485.18 CDI82151.1 - 0.045 13.5 0.1 13 5.5 0.0 2.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 CDI82151.1 - 0.073 13.1 8.0 1.4 9.0 0.0 3.9 4 0 0 4 4 3 0 AAA domain Ploopntkinase3 PF18751.1 CDI82151.1 - 0.11 12.4 6.8 1.1 9.1 0.1 3.0 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 GTP_EFTU PF00009.27 CDI82151.1 - 0.18 11.3 13.8 0.36 10.3 0.9 3.6 4 1 0 4 4 3 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 CDI82151.1 - 0.21 10.7 10.9 1.5 8.0 0.0 4.0 3 2 0 4 4 3 0 NB-ARC domain SbcCD_C PF13558.6 CDI82151.1 - 0.26 11.6 0.1 0.26 11.6 0.1 6.9 4 3 1 6 6 4 0 Putative exonuclease SbcCD, C subunit Septin PF00735.18 CDI82151.1 - 0.32 10.2 0.0 0.19 11.0 0.3 3.7 4 0 0 4 4 2 0 Septin PilZ_2 PF16823.5 CDI82152.1 - 0.047 13.9 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 Atypical PilZ domain, cyclic di-GMP receptor LSM14 PF12701.7 CDI82153.1 - 2.6e-14 53.1 0.0 4.8e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 CDI82153.1 - 4.9e-05 24.1 13.7 0.0083 17.0 4.4 2.4 1 1 1 2 2 2 2 FDF domain Spt20 PF12090.8 CDI82153.1 - 4.6 6.8 8.0 6.6 6.3 8.0 1.1 1 0 0 1 1 1 0 Spt20 family Rcd1 PF04078.13 CDI82154.1 - 3.5e-63 213.3 0.0 3.9e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TetR_C_31 PF17940.1 CDI82154.1 - 0.079 13.2 0.2 0.16 12.2 0.1 1.5 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TetR_C_11 PF16859.5 CDI82154.1 - 0.081 13.2 0.2 0.26 11.6 0.1 1.9 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RskA PF10099.9 CDI82156.1 - 0.00058 20.2 19.8 0.07 13.4 5.5 2.1 1 1 1 2 2 2 2 Anti-sigma-K factor rskA DUF4179 PF13786.6 CDI82156.1 - 0.0056 17.1 4.5 0.24 11.9 0.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4179) DUF4148 PF13663.6 CDI82156.1 - 0.017 15.3 10.8 0.61 10.3 3.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) COX7B PF05392.11 CDI82156.1 - 0.19 11.4 3.0 1.4 8.6 0.2 2.4 2 1 0 2 2 2 0 Cytochrome C oxidase chain VIIB TPP_enzyme_N PF02776.18 CDI82156.1 - 0.2 11.2 4.9 0.77 9.3 0.4 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain DUF5345 PF17280.2 CDI82156.1 - 0.21 11.6 0.3 0.21 11.6 0.3 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5345) DUF945 PF06097.11 CDI82156.1 - 0.44 9.6 15.0 0.0061 15.7 7.8 1.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF945) DUF2721 PF11026.8 CDI82156.1 - 0.65 9.9 7.5 0.088 12.7 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) DUF4834 PF16118.5 CDI82156.1 - 3.3 8.7 5.3 1.8 9.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosomal_60s PF00428.19 CDI82156.1 - 3.6 8.2 15.1 0.79 10.4 8.1 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein LapA_dom PF06305.11 CDI82156.1 - 5.5 6.9 10.2 7 6.5 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain BRCA-2_helical PF09169.10 CDI82156.1 - 6 6.5 9.1 0.31 10.7 1.0 2.0 2 0 0 2 2 2 0 BRCA2, helical P53_C PF11619.8 CDI82159.1 - 0.18 11.9 0.1 0.39 10.8 0.1 1.5 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain NHL PF01436.21 CDI82160.1 - 3.4e-17 61.5 0.2 6.6e-06 25.9 0.0 5.1 4 1 1 5 5 5 4 NHL repeat SGL PF08450.12 CDI82160.1 - 1.7e-10 40.9 0.0 1.1e-05 25.2 0.0 3.1 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 CDI82160.1 - 9.9e-06 25.0 0.0 2.5e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.20 CDI82160.1 - 0.00022 21.4 0.0 0.34 11.2 0.0 2.7 2 1 1 3 3 3 2 Arylesterase Str_synth PF03088.16 CDI82160.1 - 0.0013 18.8 0.0 0.13 12.4 0.0 2.7 2 1 1 3 3 3 1 Strictosidine synthase PQQ PF01011.21 CDI82160.1 - 0.014 15.3 1.1 1.6 8.8 0.1 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat Lustrin_cystein PF14625.6 CDI82160.1 - 0.31 11.4 34.2 0.26 11.7 7.0 4.8 1 1 2 3 3 3 0 Lustrin, cysteine-rich repeated domain Glyco_hydro_35 PF01301.19 CDI82161.1 - 8.5e-07 28.9 0.5 9.5e-06 25.4 0.0 2.4 2 1 0 2 2 2 1 Glycosyl hydrolases family 35 DUF2722 PF10846.8 CDI82161.1 - 0.00018 20.6 5.9 0.00021 20.4 5.8 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI82161.1 - 1.3 7.6 15.6 1.9 7.1 15.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.14 CDI82161.1 - 6.6 6.6 7.1 8.9 6.2 7.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Helicase_RecD PF05127.14 CDI82164.1 - 2.4e-41 141.5 0.6 3.5e-39 134.5 0.1 2.7 2 1 0 2 2 2 1 Helicase CbiM PF01891.16 CDI82164.1 - 0.0025 17.7 2.0 0.0036 17.2 2.0 1.2 1 0 0 1 1 1 1 Cobalt uptake substrate-specific transmembrane region DUF1726 PF08351.11 CDI82164.1 - 0.0083 16.0 0.0 0.023 14.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) MutS_III PF05192.18 CDI82164.1 - 0.038 14.2 0.2 0.062 13.5 0.2 1.4 1 0 0 1 1 1 0 MutS domain III FeoA PF04023.14 CDI82164.1 - 0.077 13.3 0.7 10 6.4 0.0 3.2 3 0 0 3 3 3 0 FeoA domain AAA_30 PF13604.6 CDI82164.1 - 0.51 10.0 7.3 0.54 10.0 3.5 2.5 3 0 0 3 3 3 0 AAA domain ABC2_membrane PF01061.24 CDI82166.1 - 0.039 13.4 4.5 5.7 6.3 0.3 3.1 3 0 0 3 3 3 0 ABC-2 type transporter DNA_ligase_OB_2 PF14743.6 CDI82167.1 - 0.0026 17.7 7.9 40 4.3 1.2 6.7 2 2 3 5 5 5 1 DNA ligase OB-like domain Rrf2 PF02082.20 CDI82168.1 - 0.82 10.1 4.4 1.7e+02 2.6 0.1 4.1 4 0 0 4 4 4 0 Transcriptional regulator WRNPLPNID PF15017.6 CDI82168.1 - 5 8.1 30.3 12 6.9 1.3 5.3 5 0 0 5 5 5 0 Putative WW-binding domain and destruction box CDC45 PF02724.14 CDI82169.1 - 0.035 12.4 1.2 0.054 11.8 1.2 1.2 1 0 0 1 1 1 0 CDC45-like protein SpoIIP PF07454.11 CDI82169.1 - 0.31 10.5 6.1 0.52 9.7 6.1 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 CDI82169.1 - 0.35 11.0 6.3 0.12 12.5 1.6 2.2 2 0 0 2 2 2 0 DDHD domain UPF0560 PF10577.9 CDI82169.1 - 0.67 8.4 11.0 1.2 7.5 11.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 EPL1 PF10513.9 CDI82169.1 - 3.7 7.9 10.1 3.4 8.0 8.1 1.8 2 0 0 2 2 2 0 Enhancer of polycomb-like TFIIA PF03153.13 CDI82169.1 - 6.3 6.7 33.8 0.8 9.6 21.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Paf1 PF03985.13 CDI82169.1 - 8 5.3 15.9 15 4.5 15.9 1.3 1 0 0 1 1 1 0 Paf1 Macoilin PF09726.9 CDI82172.1 - 0.054 12.1 3.4 0.064 11.8 3.4 1.1 1 0 0 1 1 1 0 Macoilin family Na_trans_assoc PF06512.13 CDI82172.1 - 0.22 11.8 6.3 0.31 11.3 6.3 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated TFIIA PF03153.13 CDI82172.1 - 0.51 10.3 26.0 0.78 9.7 26.0 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI82172.1 - 0.83 9.5 13.2 1.1 9.1 13.2 1.3 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 CDI82172.1 - 1.9 8.0 11.3 2.8 7.4 11.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI82172.1 - 3.5 6.3 5.6 4.6 5.9 5.6 1.3 1 0 0 1 1 1 0 Presenilin EF1G PF00647.19 CDI82175.1 - 7.3e-30 103.2 0.2 1.5e-29 102.2 0.2 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 CDI82175.1 - 2.6e-13 50.0 0.3 3.7e-12 46.3 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDI82175.1 - 1.6e-07 31.2 0.1 4.8e-07 29.7 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDI82175.1 - 1.1e-06 28.7 0.0 3.2e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDI82175.1 - 8.2e-05 22.9 0.0 0.0006 20.1 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain RskA PF10099.9 CDI82175.1 - 0.0015 18.9 0.1 0.0031 17.8 0.1 1.5 1 1 0 1 1 1 1 Anti-sigma-K factor rskA GST_N_3 PF13417.6 CDI82175.1 - 0.014 15.8 0.0 0.036 14.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain SR-25 PF10500.9 CDI82175.1 - 0.028 14.0 3.6 0.048 13.3 3.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Nse4_C PF08743.10 CDI82175.1 - 0.03 14.6 0.6 0.092 13.0 0.6 1.8 1 0 0 1 1 1 0 Nse4 C-terminal Tom37 PF10568.9 CDI82175.1 - 0.031 14.6 0.7 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein TCP PF03634.13 CDI82175.1 - 0.41 11.2 5.4 0.88 10.1 5.4 1.5 1 0 0 1 1 1 0 TCP family transcription factor DUF1178 PF06676.11 CDI82175.1 - 3.9 7.8 9.9 19 5.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1178) CDK2AP PF09806.9 CDI82175.1 - 6.8 6.7 13.3 0.5 10.4 7.8 1.7 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Spt20 PF12090.8 CDI82175.1 - 7.5 6.1 14.2 12 5.4 14.2 1.3 1 0 0 1 1 1 0 Spt20 family TetR_C_3 PF08362.11 CDI82177.1 - 0.18 11.7 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 YcdC-like protein, C-terminal region Utp14 PF04615.13 CDI82178.1 - 0.28 9.7 59.3 0.35 9.4 59.3 1.1 1 0 0 1 1 1 0 Utp14 protein Kri1 PF05178.12 CDI82179.1 - 2.6e-18 66.5 9.8 2.6e-18 66.5 9.8 3.3 1 1 2 3 3 3 1 KRI1-like family Hamartin PF04388.12 CDI82179.1 - 3 6.4 17.5 3.8 6.0 17.5 1.0 1 0 0 1 1 1 0 Hamartin protein Coilin_N PF15862.5 CDI82187.1 - 0.1 12.4 26.7 0.023 14.5 7.5 2.2 2 0 0 2 2 2 0 Coilin N-terminus Shadoo PF14999.6 CDI82187.1 - 0.43 10.7 13.1 0.23 11.5 1.7 2.4 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective BAF1_ABF1 PF04684.13 CDI82187.1 - 1.2 8.1 27.2 1.7 7.6 27.2 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3824 PF12868.7 CDI82187.1 - 1.6 9.4 27.9 0.33 11.6 9.4 2.3 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Hid1 PF12722.7 CDI82187.1 - 2.2 6.3 17.1 2.3 6.2 17.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3682 PF12446.8 CDI82187.1 - 2.6 8.5 37.4 0.46 11.0 14.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3682) UPF0560 PF10577.9 CDI82187.1 - 5.9 5.3 17.5 7.1 5.0 17.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF966 PF06136.13 CDI82187.1 - 8 6.1 19.8 9.5 5.8 19.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) EXOSC1 PF10447.9 CDI82192.1 - 2.6e-05 24.8 0.0 7.4e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 S1-P1_nuclease PF02265.16 CDI82194.1 - 2.2e-16 60.4 0.0 1.1e-15 58.2 0.0 1.8 1 1 0 1 1 1 1 S1/P1 Nuclease DUF3605 PF12239.8 CDI82194.1 - 0.0036 17.7 0.0 0.0099 16.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) TFIIA PF03153.13 CDI82195.1 - 0.0011 19.0 68.0 0.28 11.2 12.3 3.5 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI82197.1 - 1.6e-06 27.4 9.4 0.00034 19.7 0.0 5.4 4 2 1 5 5 3 2 Protein of unknown function (DUF2722) Pyr_redox_2 PF07992.14 CDI82197.1 - 0.00012 21.4 0.2 0.0094 15.2 0.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase RR_TM4-6 PF06459.12 CDI82197.1 - 0.00023 21.1 17.4 0.00023 21.1 17.4 3.5 3 1 0 3 3 3 1 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CDI82197.1 - 0.0029 17.3 11.2 0.0029 17.3 11.2 6.0 5 1 1 6 6 4 2 Spt20 family Presenilin PF01080.17 CDI82197.1 - 0.013 14.3 47.7 0.39 9.4 22.8 3.5 3 0 0 3 3 3 0 Presenilin N6_N4_Mtase PF01555.18 CDI82197.1 - 0.058 13.1 0.0 2.5 7.8 0.0 3.2 2 1 0 2 2 2 0 DNA methylase Lin-8 PF03353.15 CDI82197.1 - 0.12 11.9 51.1 0.064 12.8 20.6 4.0 4 0 0 4 4 4 0 Ras-mediated vulval-induction antagonist NAD_binding_8 PF13450.6 CDI82197.1 - 0.14 12.4 0.0 0.14 12.4 0.0 2.4 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain Ctr PF04145.15 CDI82197.1 - 0.46 11.1 0.1 0.46 11.1 0.1 4.7 4 1 0 4 4 4 0 Ctr copper transporter family SAPS PF04499.15 CDI82197.1 - 0.96 8.2 30.9 1.5 7.5 0.0 3.1 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein GAGA_bind PF06217.12 CDI82197.1 - 1.2 9.4 35.2 0.23 11.7 13.3 3.2 3 0 0 3 3 3 0 GAGA binding protein-like family CNDH2_C PF16858.5 CDI82197.1 - 2.9 7.7 40.1 4.1 7.2 21.1 3.3 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Exonuc_VII_L PF02601.15 CDI82197.1 - 3.3 7.2 44.2 0.5 9.9 18.2 3.3 3 0 0 3 3 3 0 Exonuclease VII, large subunit CCSAP PF15748.5 CDI82197.1 - 6 7.0 56.4 0.034 14.3 18.1 3.8 3 1 0 3 3 3 0 Centriole, cilia and spindle-associated MDM31_MDM32 PF08118.11 CDI82197.1 - 9.5 4.8 23.1 2.4 6.7 9.2 3.4 3 0 0 3 3 3 0 Yeast mitochondrial distribution and morphology (MDM) proteins Tmemb_185A PF10269.9 CDI82198.1 - 1.7 8.3 5.0 1.2 8.7 0.1 2.4 2 1 1 3 3 3 0 Transmembrane Fragile-X-F protein Cnd1 PF12717.7 CDI82200.1 - 2.5e-12 47.1 1.3 9.1e-06 25.8 0.0 4.2 2 2 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 BUD22 PF09073.10 CDI82200.1 - 7.4e-05 22.3 27.7 0.00024 20.6 14.6 4.9 5 1 1 6 6 6 3 BUD22 SDA1 PF05285.12 CDI82200.1 - 0.013 15.0 0.5 0.013 15.0 0.5 5.0 5 1 0 5 5 5 0 SDA1 Cohesin_HEAT PF12765.7 CDI82200.1 - 0.19 12.1 2.9 0.46 10.8 1.3 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Kelch_1 PF01344.25 CDI82210.1 - 2.4 7.8 7.8 2.4 7.8 0.5 3.1 3 0 0 3 3 3 0 Kelch motif DUF2722 PF10846.8 CDI82211.1 - 0.00059 18.9 0.5 0.00059 18.9 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Abhydrolase_9_N PF15420.6 CDI82211.1 - 0.0036 17.3 1.2 0.0046 17.0 1.2 1.1 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus DUF5308 PF17233.2 CDI82211.1 - 0.023 15.0 0.3 0.029 14.6 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF2397 PF09660.10 CDI82211.1 - 0.03 13.2 0.5 0.036 13.0 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) KleE PF17394.2 CDI82211.1 - 0.053 13.8 0.2 0.085 13.1 0.2 1.4 1 1 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Med15 PF09606.10 CDI82211.1 - 0.056 12.1 8.6 0.054 12.2 8.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Roughex PF06020.11 CDI82211.1 - 0.16 11.0 2.2 0.18 10.9 2.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein DUF5336 PF17270.2 CDI82211.1 - 0.26 10.9 3.5 0.45 10.1 3.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5336) CrgA PF06781.12 CDI82211.1 - 0.39 10.8 2.0 0.58 10.2 0.5 1.9 1 1 1 2 2 2 0 Cell division protein CrgA Spt20 PF12090.8 CDI82211.1 - 0.99 9.0 14.8 1.3 8.6 14.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI82211.1 - 3 8.8 6.0 4.8 8.2 6.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DivIC PF04977.15 CDI82211.1 - 3.6 7.4 9.3 5.3 6.9 9.3 1.2 1 0 0 1 1 1 0 Septum formation initiator Med3 PF11593.8 CDI82211.1 - 4.7 6.3 12.8 5.8 6.0 12.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Androgen_recep PF02166.16 CDI82211.1 - 5.9 5.6 15.0 7.6 5.3 15.0 1.1 1 0 0 1 1 1 0 Androgen receptor SHS2_Rpb7-N PF03876.17 CDI82212.1 - 1e-12 48.2 0.0 1.4e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 TFIIA PF03153.13 CDI82213.1 - 2.3e-05 24.6 30.1 2.9e-05 24.2 30.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit NUC153 PF08159.12 CDI82213.1 - 0.0048 16.7 0.6 0.028 14.2 0.1 2.3 2 0 0 2 2 2 1 NUC153 domain IMUP PF15761.5 CDI82213.1 - 0.028 15.1 11.1 0.028 15.1 11.1 4.6 3 1 2 5 5 5 0 Immortalisation up-regulated protein SR-25 PF10500.9 CDI82214.1 - 0.022 14.3 12.7 0.035 13.7 12.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4614 PF15391.6 CDI82214.1 - 0.23 11.4 6.4 0.066 13.2 3.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) AF-4 PF05110.13 CDI82214.1 - 0.58 8.2 13.5 0.77 7.8 13.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SOG2 PF10428.9 CDI82214.1 - 0.98 8.5 9.2 1.2 8.2 9.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF515 PF04415.12 CDI82214.1 - 2.9 6.2 7.0 3.7 5.8 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF508 PF04370.12 CDI82214.1 - 9.6 5.9 8.4 20 4.9 8.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF508) TFIIA PF03153.13 CDI82222.1 - 0.012 15.6 9.8 0.018 15.1 9.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI82222.1 - 0.054 13.5 2.5 0.089 12.8 2.5 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0560 PF10577.9 CDI82222.1 - 0.77 8.2 15.3 1.2 7.5 13.8 1.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0560 Spt20 PF12090.8 CDI82222.1 - 1.8 8.1 17.2 2.9 7.5 17.2 1.2 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI82222.1 - 2.4 7.0 12.7 3.5 6.5 12.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FxsA PF04186.13 CDI82222.1 - 7.2 6.8 6.5 0.36 11.0 0.1 2.1 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein DUF4834 PF16118.5 CDI82222.1 - 9.1 7.3 7.7 38 5.3 5.7 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) HAT PF02184.16 CDI82223.1 - 0.00028 20.8 2.4 0.29 11.1 0.0 3.4 3 0 0 3 3 3 2 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 CDI82223.1 - 0.00032 21.3 5.5 1.1 10.2 0.1 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDI82223.1 - 0.034 14.7 1.2 0.11 13.1 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat PI-TkoII_IV PF18714.1 CDI82223.1 - 0.066 12.7 0.1 0.13 11.7 0.1 1.5 1 1 0 1 1 1 0 DNA polymerase II intein Domain IV TPR_6 PF13174.6 CDI82223.1 - 0.65 10.8 2.7 5.3 7.9 0.2 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat SNF PF00209.18 CDI82230.1 - 4.4e-05 22.4 0.1 4.4e-05 22.4 0.1 2.4 2 0 0 2 2 2 1 Sodium:neurotransmitter symporter family Sec2p PF06428.11 CDI82232.1 - 0.025 14.6 21.6 0.045 13.7 5.4 2.7 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p SlyX PF04102.12 CDI82232.1 - 0.5 11.0 19.5 3.3 8.4 3.4 3.0 2 0 0 2 2 2 0 SlyX TMF_TATA_bd PF12325.8 CDI82232.1 - 1.4 9.2 23.7 0.17 12.1 9.8 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 CDI82232.1 - 3.7 6.8 29.6 0.67 9.2 25.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) AAA_lid_9 PF17871.1 CDI82232.1 - 7.4 6.6 16.0 0.54 10.2 3.1 3.0 2 1 0 2 2 2 0 AAA lid domain Laminin_B PF00052.18 CDI82233.1 - 2.6 7.9 7.0 1.6 8.7 1.2 2.9 1 1 1 2 2 2 0 Laminin B (Domain IV) SF-assemblin PF06705.11 CDI82234.1 - 1.3e-21 77.0 6.8 3.5e-20 72.4 6.8 2.0 1 1 1 2 2 2 1 SF-assemblin/beta giardin Apolipoprotein PF01442.18 CDI82234.1 - 0.015 15.2 14.3 0.1 12.5 1.4 2.3 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain SHE3 PF17078.5 CDI82234.1 - 0.019 14.7 0.7 0.043 13.5 0.7 1.6 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Pex19 PF04614.12 CDI82234.1 - 0.085 12.6 1.1 0.13 12.0 1.1 1.3 1 0 0 1 1 1 0 Pex19 protein family HMMR_N PF15905.5 CDI82234.1 - 0.095 12.2 4.6 0.52 9.7 1.3 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal PCRF PF03462.18 CDI82234.1 - 0.12 12.3 3.2 0.09 12.6 1.7 1.6 1 1 1 2 2 2 0 PCRF domain Mst1_SARAH PF11629.8 CDI82234.1 - 0.15 12.2 3.4 3.1 8.0 0.2 3.6 3 1 1 4 4 4 0 C terminal SARAH domain of Mst1 GPS2_interact PF15784.5 CDI82234.1 - 0.16 12.4 1.3 0.33 11.4 0.9 1.7 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Exonuc_VII_L PF02601.15 CDI82234.1 - 0.19 11.3 3.2 0.24 10.9 3.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit YlqD PF11068.8 CDI82234.1 - 0.2 12.1 3.3 0.34 11.3 1.0 2.1 1 1 1 2 2 2 0 YlqD protein DUF4404 PF14357.6 CDI82234.1 - 0.38 11.4 5.1 16 6.2 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) FUSC PF04632.12 CDI82234.1 - 0.77 8.2 11.1 1.5 7.2 11.1 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family OmpH PF03938.14 CDI82234.1 - 1 9.7 5.6 2.5 8.4 5.2 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Uds1 PF15456.6 CDI82234.1 - 1.6 8.9 9.5 7.9 6.7 7.9 2.7 1 1 1 2 2 2 0 Up-regulated During Septation Nup54 PF13874.6 CDI82234.1 - 2.4 8.3 6.4 1.6 8.8 3.8 2.0 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 TipAS PF07739.13 CDI82234.1 - 5 7.7 6.6 9.9 6.7 0.4 2.8 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain Spc7 PF08317.11 CDI82234.1 - 8.8 5.1 9.5 39 3.0 9.3 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein Phage_Mu_Gam PF07352.12 CDI82234.1 - 9.6 6.1 7.9 5.6 6.9 1.7 2.3 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein zf-C2H2 PF00096.26 CDI82235.1 - 9e-06 25.9 0.3 1.7e-05 25.0 0.3 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type Prefoldin_2 PF01920.20 CDI82235.1 - 0.0069 16.3 6.5 0.0069 16.3 6.5 3.3 3 1 0 3 3 3 1 Prefoldin subunit XPA_N PF01286.18 CDI82235.1 - 0.0069 16.4 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 XPA protein N-terminal zf-C2H2_3rep PF18868.1 CDI82235.1 - 0.011 16.5 1.7 0.079 13.6 0.0 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 CDI82235.1 - 0.022 15.6 0.3 0.046 14.6 0.3 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger DUF5320 PF17253.2 CDI82235.1 - 0.032 15.3 4.1 0.76 10.9 1.7 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5320) zf-C2H2_jaz PF12171.8 CDI82235.1 - 0.088 13.1 0.9 0.23 11.8 0.9 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Tweety PF04906.13 CDI82235.1 - 0.68 8.5 6.9 4.6 5.8 1.8 2.3 2 0 0 2 2 2 0 Tweety DUF349 PF03993.12 CDI82235.1 - 7.4 7.0 9.1 3.7 7.9 1.0 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) zf-CCHC PF00098.23 CDI82237.1 - 0.0015 18.5 3.6 0.0036 17.3 3.6 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CDI82237.1 - 0.038 13.7 0.4 0.071 12.9 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 CDI82237.1 - 0.18 11.5 3.0 0.61 9.8 3.0 1.9 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Notch PF00066.17 CDI82238.1 - 4.7 7.8 9.5 0.21 12.1 2.7 2.2 3 0 0 3 3 3 0 LNR domain DUF4358 PF14270.6 CDI82239.1 - 0.097 13.0 3.8 9.1 6.6 0.1 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4358) Pkinase PF00069.25 CDI82240.1 - 0.047 13.0 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain LRR_9 PF14580.6 CDI82242.1 - 0.0002 20.9 0.0 0.00031 20.3 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat TolA_bind_tri PF16331.5 CDI82243.1 - 0.0029 17.6 1.7 0.0029 17.6 1.7 9.1 6 2 4 10 10 10 3 TolA binding protein trimerisation SlyX PF04102.12 CDI82243.1 - 0.11 13.1 0.4 0.11 13.1 0.4 10.8 3 1 5 10 10 10 0 SlyX AAA_lid_11 PF18198.1 CDI82246.1 - 2.8e-20 72.8 0.0 4.2e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Ribosomal_60s PF00428.19 CDI82246.1 - 0.016 15.7 9.5 0.016 15.7 9.5 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein SprA-related PF12118.8 CDI82247.1 - 0.02 14.1 13.9 0.022 13.9 13.9 1.0 1 0 0 1 1 1 0 SprA-related family CTNNB1_binding PF08347.11 CDI82247.1 - 0.057 13.6 7.5 0.074 13.2 7.5 1.2 1 0 0 1 1 1 0 N-terminal CTNNB1 binding DUF1835 PF08874.10 CDI82247.1 - 0.19 11.9 5.2 0.22 11.8 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) Spt20 PF12090.8 CDI82247.1 - 0.22 11.1 24.6 0.26 10.9 24.6 1.1 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CDI82247.1 - 1.1 9.2 9.2 1.1 9.2 9.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 CDI82247.1 - 1.6 9.8 8.7 1.9 9.5 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI82247.1 - 9.2 4.9 8.8 9.3 4.9 8.8 1.0 1 0 0 1 1 1 0 Presenilin Pilin PF00114.19 CDI82249.1 - 0.07 14.1 7.8 0.09 13.7 7.8 1.2 1 0 0 1 1 1 0 Pilin (bacterial filament) TFIIA PF03153.13 CDI82249.1 - 0.24 11.3 32.1 0.29 11.1 32.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI82249.1 - 0.61 10.1 6.5 0.65 10.0 6.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MMR1 PF08505.10 CDI82249.1 - 0.81 9.9 13.4 1.2 9.3 13.4 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Synuclein PF01387.17 CDI82249.1 - 1 9.6 11.0 0.17 12.1 7.1 1.6 1 1 1 2 2 2 0 Synuclein DDHD PF02862.17 CDI82249.1 - 1.2 9.2 10.2 1.4 9.1 10.2 1.2 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 CDI82249.1 - 2.1 7.3 5.7 2.8 6.9 5.7 1.2 1 0 0 1 1 1 0 CLN3 protein NEMP PF10225.9 CDI82249.1 - 2.2 7.9 5.0 2.7 7.6 5.0 1.2 1 0 0 1 1 1 0 NEMP family Presenilin PF01080.17 CDI82249.1 - 2.3 6.9 11.0 2.8 6.6 11.0 1.2 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 CDI82249.1 - 2.7 7.6 23.9 3.5 7.2 23.9 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CDI82249.1 - 3.3 7.6 12.6 3.6 7.5 12.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TERB2 PF15101.6 CDI82249.1 - 4.1 7.4 14.8 6.1 6.8 14.8 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RIFIN PF02009.16 CDI82249.1 - 5.4 6.8 13.4 7.1 6.4 13.4 1.2 1 0 0 1 1 1 0 Rifin PAT1 PF09770.9 CDI82249.1 - 7.9 4.6 21.7 8.9 4.4 21.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DNA_pol_D_N PF18018.1 CDI82254.1 - 5.2e-11 42.8 0.0 4.4e-10 39.8 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Ribosomal_60s PF00428.19 CDI82254.1 - 2.4e-05 24.8 27.3 0.018 15.6 10.9 2.3 2 0 0 2 2 2 2 60s Acidic ribosomal protein RIFIN PF02009.16 CDI82254.1 - 0.065 13.1 1.9 0.085 12.7 1.9 1.1 1 0 0 1 1 1 0 Rifin DUF3138 PF11336.8 CDI82254.1 - 0.23 10.0 20.6 0.058 12.0 7.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Sugar_tr PF00083.24 CDI82256.1 - 0.24 10.2 1.4 0.37 9.6 1.4 1.2 1 0 0 1 1 1 0 Sugar (and other) transporter BT1 PF03092.16 CDI82256.1 - 0.29 9.3 3.4 0.55 8.4 3.4 1.4 1 0 0 1 1 1 0 BT1 family MFS_1 PF07690.16 CDI82256.1 - 0.43 9.4 9.0 0.75 8.7 9.0 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily cNMP_binding PF00027.29 CDI82258.1 - 4.5e-20 71.5 0.1 1.2e-09 38.1 0.0 4.2 3 1 1 4 4 4 3 Cyclic nucleotide-binding domain Pkinase PF00069.25 CDI82258.1 - 2.6e-08 33.6 0.0 4.4e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Cupin_3 PF05899.12 CDI82258.1 - 0.0097 15.6 0.0 7.2 6.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Cupin_2 PF07883.11 CDI82258.1 - 0.1 12.4 1.1 27 4.5 0.1 3.3 3 1 0 3 3 3 0 Cupin domain SR-25 PF10500.9 CDI82261.1 - 9.3e-05 22.1 19.3 9.3e-05 22.1 19.3 5.4 2 1 1 5 5 5 2 Nuclear RNA-splicing-associated protein KptA_kDCL PF18176.1 CDI82263.1 - 0.049 13.5 0.4 0.052 13.4 0.4 1.1 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain BIV_Env PF05858.12 CDI82263.1 - 0.24 9.5 0.1 0.25 9.5 0.1 1.0 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) Shadoo PF14999.6 CDI82269.1 - 0.069 13.3 1.6 0.11 12.6 1.6 1.3 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective DUF2065 PF09838.9 CDI82273.1 - 0.012 15.7 0.1 5.2 7.2 0.0 3.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2065) AstA PF04958.12 CDI82274.1 - 0.17 10.4 0.1 0.25 9.8 0.1 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit NINJA_B PF16136.5 CDI82274.1 - 1.9 8.9 6.4 1.2 9.6 3.8 1.9 2 0 0 2 2 2 0 Putative nuclear localisation signal Aminotran_1_2 PF00155.21 CDI82275.1 - 3.3e-37 128.5 0.0 4.3e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.20 CDI82275.1 - 0.0001 21.2 0.0 0.00052 18.9 0.0 1.8 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 CDI82275.1 - 0.00028 20.3 0.2 0.00071 19.0 0.2 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CDI82275.1 - 0.0003 19.5 0.0 0.00046 18.8 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CDI82275.1 - 0.032 13.5 0.1 0.06 12.6 0.1 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase NHL PF01436.21 CDI82275.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 NHL repeat Glyco_transf_17 PF04724.13 CDI82275.1 - 0.13 11.2 0.1 0.24 10.4 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 17 DUF1364 PF07102.12 CDI82276.1 - 4.9 7.1 8.5 8.8 6.3 0.5 4.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1364) LUC7 PF03194.15 CDI82277.1 - 0.0003 20.6 0.1 0.00035 20.3 0.1 1.1 1 0 0 1 1 1 1 LUC7 N_terminus RIFIN PF02009.16 CDI82278.1 - 0.74 9.6 12.0 0.035 14.0 1.5 2.0 1 1 1 2 2 2 0 Rifin HSP70 PF00012.20 CDI82279.1 - 2.1e-34 118.7 0.0 3e-17 62.1 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CDI82279.1 - 0.0045 15.8 0.3 0.19 10.5 0.1 2.0 2 0 0 2 2 2 2 MreB/Mbl protein Carb_anhydrase PF00194.21 CDI82281.1 - 9.3e-19 68.0 11.1 1.4e-18 67.4 2.1 3.3 2 1 0 3 3 3 1 Eukaryotic-type carbonic anhydrase SUIM_assoc PF16619.5 CDI82281.1 - 0.0063 16.5 1.6 0.0063 16.5 1.6 4.7 3 1 1 4 4 3 1 Unstructured region C-term to UIM in Ataxin3 DUF3306 PF11748.8 CDI82281.1 - 0.0063 17.4 4.3 0.0063 17.4 4.3 3.0 3 1 0 3 3 2 1 Protein of unknown function (DUF3306) RskA PF10099.9 CDI82281.1 - 0.011 16.0 25.0 11 6.2 20.9 3.2 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF4421 PF14391.6 CDI82281.1 - 0.019 14.3 0.4 0.038 13.4 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4421) SR-25 PF10500.9 CDI82281.1 - 0.061 12.9 0.3 0.061 12.9 0.3 2.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI82281.1 - 0.23 11.4 34.9 0.48 10.4 18.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EBP50_C PF09007.11 CDI82281.1 - 0.7 10.9 11.5 4.8 8.2 0.6 3.3 3 0 0 3 3 3 0 EBP50, C-terminal DUF3801 PF12687.7 CDI82281.1 - 2.5 8.1 16.3 0.68 10.0 3.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) Ndc1_Nup PF09531.10 CDI82281.1 - 3.8 6.1 10.1 0.84 8.2 1.4 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup ANAPC_CDC26 PF10471.9 CDI82281.1 - 7.9 7.4 35.3 4.4 8.2 1.5 4.0 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 EIF_2_alpha PF07541.12 CDI82282.1 - 3.1e-23 82.1 0.0 3.4e-23 82.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit DUF3071 PF11268.8 CDI82290.1 - 0.019 15.0 0.1 0.03 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Ribosomal_60s PF00428.19 CDI82291.1 - 0.0032 18.0 0.3 0.0032 18.0 0.3 4.3 3 1 1 4 4 4 1 60s Acidic ribosomal protein SLC12 PF03522.15 CDI82291.1 - 0.014 14.5 15.5 0.022 13.8 15.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Caldesmon PF02029.15 CDI82291.1 - 0.081 11.7 28.0 0.15 10.8 28.0 1.4 1 0 0 1 1 1 0 Caldesmon DUF4407 PF14362.6 CDI82291.1 - 2.5 7.4 19.6 3.9 6.7 19.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BSP_II PF05432.11 CDI82291.1 - 8.3 6.0 27.5 7.4 6.2 6.0 2.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) ATP-synt_D PF01813.17 CDI82294.1 - 1.5e-19 70.7 0.0 1.6e-19 70.5 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit D CA_like PF10563.9 CDI82294.1 - 0.064 13.2 0.0 0.077 12.9 0.0 1.1 1 0 0 1 1 1 0 Putative carbonic anhydrase TFIIA PF03153.13 CDI82295.1 - 0.0072 16.4 14.9 0.0089 16.1 14.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Tmemb_9 PF05434.11 CDI82295.1 - 0.21 11.5 12.7 0.067 13.1 1.7 2.6 1 1 2 3 3 3 0 TMEM9 DUF2052 PF09747.9 CDI82295.1 - 0.66 10.1 14.2 1.1 9.4 14.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TIMELESS PF04821.14 CDI82295.1 - 0.66 9.2 8.0 1.4 8.1 8.0 1.4 1 0 0 1 1 1 0 Timeless protein DUF966 PF06136.13 CDI82295.1 - 1.8 8.2 9.8 2.3 7.9 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) ANAPC8 PF04049.13 CDI82295.1 - 2.5 8.2 7.5 0.32 11.0 1.7 2.1 2 1 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 IQ PF00612.27 CDI82298.1 - 0.15 12.0 0.5 8.6 6.5 0.1 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif DNA_pol_B PF00136.21 CDI82300.1 - 2.2e-35 122.3 2.9 3.9e-35 121.5 2.9 1.4 1 1 0 1 1 1 1 DNA polymerase family B DUF2722 PF10846.8 CDI82300.1 - 0.00082 18.4 14.4 0.0032 16.5 7.3 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI82300.1 - 0.012 15.7 1.7 0.012 15.7 1.7 3.2 2 1 0 2 2 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4834 PF16118.5 CDI82300.1 - 0.014 16.4 8.9 0.59 11.1 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SYF2 PF08231.12 CDI82300.1 - 0.055 13.9 6.8 0.64 10.4 1.4 2.3 2 0 0 2 2 2 0 SYF2 splicing factor Presenilin PF01080.17 CDI82300.1 - 0.063 12.0 2.6 0.095 11.5 2.6 1.2 1 0 0 1 1 1 0 Presenilin EPL1 PF10513.9 CDI82300.1 - 0.091 13.1 5.4 0.44 10.9 2.2 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like BRF1 PF07741.13 CDI82300.1 - 0.12 12.7 9.0 3.6 8.0 3.9 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain MAM33 PF02330.16 CDI82300.1 - 0.13 12.1 6.0 4 7.3 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial glycoprotein baeRF_family7 PF18849.1 CDI82300.1 - 0.22 11.7 7.5 2.2 8.5 0.1 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 7 LIM PF00412.22 CDI82300.1 - 0.24 11.7 3.7 1.6 9.0 1.4 2.8 2 1 0 2 2 2 0 LIM domain RskA PF10099.9 CDI82300.1 - 0.56 10.5 19.7 15 5.8 19.7 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA AAR2 PF05282.11 CDI82300.1 - 0.58 9.5 5.7 2.6 7.4 6.1 1.6 1 1 0 1 1 1 0 AAR2 protein Folliculin PF11704.8 CDI82300.1 - 0.62 9.9 3.6 3 7.7 0.6 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF775 PF05603.12 CDI82300.1 - 0.82 9.2 8.5 3.3 7.2 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF775) DUF2407 PF10302.9 CDI82300.1 - 0.86 10.2 4.5 0.34 11.5 1.1 2.1 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain DUF3306 PF11748.8 CDI82300.1 - 1.1 10.1 10.1 2 9.3 2.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) TERB2 PF15101.6 CDI82300.1 - 2 8.4 10.8 1.1 9.2 4.8 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF3381 PF11861.8 CDI82300.1 - 4.5 7.0 14.1 5.1 6.9 1.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Zn-ribbon_8 PF09723.10 CDI82300.1 - 8.9 6.5 8.4 0.34 11.1 0.4 2.5 2 1 1 3 3 3 0 Zinc ribbon domain DAO_C PF16901.5 CDI82301.1 - 1.1e-19 70.5 0.0 2.7e-19 69.3 0.0 1.7 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase DAO PF01266.24 CDI82301.1 - 2.7e-13 50.2 0.1 4.2e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase PP2C PF00481.21 CDI82303.1 - 1.9e-05 24.4 0.0 0.031 13.9 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C Ribosomal_L13 PF00572.18 CDI82304.1 - 0.0031 17.8 0.0 0.0041 17.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 FerI PF08151.12 CDI82308.1 - 0.22 11.6 0.1 0.22 11.6 0.1 3.0 3 0 0 3 3 3 0 FerI (NUC094) domain Histone PF00125.24 CDI82313.1 - 2.9e-17 63.2 0.0 4e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CDI82313.1 - 6.5e-11 41.8 0.1 1.3e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CDI82313.1 - 8.3e-05 22.8 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CemA PF03040.14 CDI82318.1 - 0.0025 17.8 2.0 0.004 17.1 2.0 1.2 1 0 0 1 1 1 1 CemA family DUF3810 PF12725.7 CDI82318.1 - 0.018 14.4 0.2 0.026 13.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) HemX PF04375.14 CDI82318.1 - 0.02 14.2 12.6 0.035 13.4 12.6 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase SAPS PF04499.15 CDI82318.1 - 0.04 12.7 8.1 0.0098 14.7 5.3 1.4 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein V_ATPase_I PF01496.19 CDI82318.1 - 0.045 11.7 5.8 0.066 11.1 5.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3402 PF11882.8 CDI82318.1 - 0.05 12.7 5.7 0.079 12.0 5.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DUF2828 PF11443.8 CDI82318.1 - 0.061 11.4 6.6 0.086 10.9 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S49_N PF08496.10 CDI82318.1 - 0.079 13.0 1.9 0.2 11.7 1.9 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OATP PF03137.20 CDI82318.1 - 0.11 10.7 0.2 0.17 10.1 0.2 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family O-antigen_lig PF13425.6 CDI82318.1 - 0.26 10.0 0.7 0.36 9.6 0.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4746 PF15928.5 CDI82318.1 - 0.29 10.5 12.3 0.5 9.7 12.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CDI82318.1 - 0.31 9.9 3.0 0.48 9.3 3.0 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) MAP17 PF15807.5 CDI82318.1 - 0.64 10.3 6.6 1.6 9.0 3.3 2.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PGA2 PF07543.12 CDI82318.1 - 1.1 9.2 12.4 0.078 13.0 5.9 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 CENP-B_dimeris PF09026.10 CDI82318.1 - 1.3 9.4 10.4 0.21 12.0 5.9 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4407 PF14362.6 CDI82318.1 - 1.5 8.1 9.4 2.4 7.4 9.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TRAP_alpha PF03896.16 CDI82318.1 - 2.1 7.5 8.6 0.33 10.1 4.8 1.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Secretin_N_2 PF07655.13 CDI82318.1 - 4.2 8.0 27.4 0.27 11.8 5.1 3.1 3 1 0 3 3 2 0 Secretin N-terminal domain SID-1_RNA_chan PF13965.6 CDI82318.1 - 4.3 5.6 5.9 2.5 6.4 3.9 1.5 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DDRGK PF09756.9 CDI82318.1 - 4.7 6.8 19.1 9.3 5.8 19.1 1.4 1 0 0 1 1 1 0 DDRGK domain Saw1 PF11561.8 CDI82318.1 - 5.9 6.3 10.3 2.5 7.6 7.3 1.7 2 0 0 2 2 2 0 Single strand annealing-weakened 1 Dynactin_p62 PF05502.13 CDI82318.1 - 6 5.5 11.2 0.48 9.1 6.7 1.5 2 0 0 2 2 2 0 Dynactin p62 family Sod_Fe_C PF02777.18 CDI82321.1 - 0.02 15.1 0.0 0.062 13.5 0.0 1.7 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, C-terminal domain RNase_T PF00929.24 CDI82322.1 - 1.6e-05 25.5 0.2 0.00013 22.5 0.0 2.4 2 1 0 2 2 2 1 Exonuclease Myc_N PF01056.18 CDI82322.1 - 0.0084 16.1 8.5 0.24 11.3 2.5 2.6 2 1 0 2 2 2 2 Myc amino-terminal region Cwf_Cwc_15 PF04889.12 CDI82322.1 - 0.0096 15.7 5.6 0.0096 15.7 5.6 2.3 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein UPF0565 PF10561.9 CDI82322.1 - 0.33 10.1 1.4 0.68 9.1 1.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Vfa1 PF08432.10 CDI82322.1 - 0.52 10.6 10.2 2.4 8.5 6.1 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 CDI82322.1 - 1.5 7.7 4.9 0.39 9.7 1.3 1.7 2 0 0 2 2 2 0 Solute carrier family 12 DARPP-32 PF05395.12 CDI82322.1 - 1.6 8.9 12.6 3.3 7.9 8.1 2.2 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 Coilin_N PF15862.5 CDI82322.1 - 2 8.2 7.0 0.18 11.6 1.2 2.1 2 0 0 2 2 2 0 Coilin N-terminus CKS PF01111.19 CDI82323.1 - 2.9e-08 33.9 0.2 4.9e-08 33.1 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PI3K_1B_p101 PF10486.9 CDI82323.1 - 2.9 5.5 14.4 4.5 4.9 14.4 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TraG-D_C PF12696.7 CDI82323.1 - 9.2 6.3 10.1 7.8 6.5 7.8 2.1 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG GBP PF02263.19 CDI82329.1 - 3.8e-26 91.9 0.1 5.4e-18 65.2 0.0 3.2 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain PmbA_TldD PF01523.16 CDI82329.1 - 0.00013 21.9 0.4 0.29 10.9 0.1 2.5 1 1 1 2 2 2 2 Putative modulator of DNA gyrase GBP_C PF02841.14 CDI82329.1 - 0.00027 20.4 0.0 0.00036 20.0 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Dynamin_N PF00350.23 CDI82329.1 - 0.0034 17.4 0.9 3.1 7.8 0.1 2.5 2 0 0 2 2 2 2 Dynamin family AAA_22 PF13401.6 CDI82329.1 - 0.29 11.4 2.2 33 4.7 0.0 3.3 4 0 0 4 4 4 0 AAA domain LRR_9 PF14580.6 CDI82331.1 - 2.2e-33 115.2 0.1 2.5e-33 115.0 0.1 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 CDI82331.1 - 8.5e-07 28.6 5.4 3.6e-06 26.6 1.9 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDI82331.1 - 2.1e-06 28.0 7.7 0.00041 20.7 3.4 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDI82331.1 - 2 9.3 9.2 34 5.5 0.2 4.1 4 1 0 4 4 4 0 Leucine Rich Repeat AAA_8 PF12780.7 CDI82333.1 - 1.1e-35 123.3 1.6 9.1e-26 90.7 0.4 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region D4 SPX PF03105.19 CDI82333.1 - 0.00024 21.2 2.4 0.00024 21.2 2.4 2.1 2 0 0 2 2 2 1 SPX domain DUF4834 PF16118.5 CDI82333.1 - 0.0014 19.5 5.9 0.0014 19.5 5.9 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4834) RskA PF10099.9 CDI82333.1 - 0.015 15.6 2.4 0.015 15.6 2.4 2.9 2 1 0 2 2 1 0 Anti-sigma-K factor rskA DUF4199 PF13858.6 CDI82333.1 - 0.12 12.8 0.9 0.25 11.7 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Secretin_N_2 PF07655.13 CDI82333.1 - 0.15 12.6 0.2 0.15 12.6 0.2 3.4 3 0 0 3 3 3 0 Secretin N-terminal domain AAA_lid_1 PF17857.1 CDI82333.1 - 0.16 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA+ lid domain Ribosomal_60s PF00428.19 CDI82333.1 - 0.23 12.1 13.8 0.99 10.0 0.0 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein PepSY_TM_like_2 PF16357.5 CDI82333.1 - 0.24 11.3 1.3 0.52 10.3 1.3 1.5 1 0 0 1 1 1 0 Putative PepSY_TM-like EOS1 PF12326.8 CDI82333.1 - 1.1 9.1 4.6 1 9.3 0.3 2.2 2 0 0 2 2 2 0 N-glycosylation protein CLN3 PF02487.17 CDI82333.1 - 2.5 7.1 6.0 0.48 9.4 1.7 1.8 2 0 0 2 2 2 0 CLN3 protein CPSF100_C PF13299.6 CDI82333.1 - 6.1 7.0 11.3 5.3 7.2 5.4 2.6 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DHFR_1 PF00186.19 CDI82334.1 - 1.3e-15 57.5 0.0 1.8e-06 27.8 0.0 2.2 2 0 0 2 2 2 2 Dihydrofolate reductase DUF3606 PF12244.8 CDI82335.1 - 0.031 14.2 0.1 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) DUF4598 PF15370.6 CDI82335.1 - 0.12 12.8 0.7 0.22 12.0 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) Dynein_heavy PF03028.15 CDI82336.1 - 2.6e-40 137.2 0.0 3.2e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain Glyco_transf_20 PF00982.21 CDI82338.1 - 6.3e-07 28.4 0.0 1.3e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 20 Spt20 PF12090.8 CDI82338.1 - 0.026 14.1 29.4 0.53 9.9 27.8 2.3 2 0 0 2 2 2 0 Spt20 family eIF-3_zeta PF05091.12 CDI82338.1 - 0.057 12.4 7.6 0.079 11.9 7.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1682 PF07946.14 CDI82338.1 - 0.11 11.7 5.1 0.16 11.2 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pex14_N PF04695.13 CDI82338.1 - 0.2 12.3 23.2 1.3 9.7 12.4 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Connexin PF00029.19 CDI82338.1 - 0.31 10.8 4.7 0.5 10.1 4.7 1.3 1 0 0 1 1 1 0 Connexin DUF4746 PF15928.5 CDI82338.1 - 0.34 10.3 10.4 0.18 11.2 5.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Baculo_PP31 PF05311.11 CDI82338.1 - 0.79 9.2 7.6 1.5 8.3 7.6 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) V_ATPase_I PF01496.19 CDI82338.1 - 2 6.3 10.7 2.7 5.8 10.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF935 PF06074.12 CDI82338.1 - 2 7.1 21.0 1.1 7.9 7.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF935) DUF4834 PF16118.5 CDI82338.1 - 2.1 9.4 14.6 0.42 11.6 9.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 CDI82338.1 - 3.8 7.2 11.3 1.2 8.7 7.9 1.9 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.14 CDI82338.1 - 4.9 6.9 15.6 2 8.2 5.9 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CPSF100_C PF13299.6 CDI82338.1 - 6 7.0 18.3 3.9 7.6 7.8 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4199 PF13858.6 CDI82338.1 - 7.7 6.9 6.1 19 5.6 6.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF4770 PF15994.5 CDI82338.1 - 9.5 6.4 13.3 18 5.5 13.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Pet191_N PF10203.9 CDI82339.1 - 4.8 7.6 11.6 5.7 7.3 0.0 3.8 2 1 1 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Secretin_N_2 PF07655.13 CDI82344.1 - 0.53 10.9 11.6 0.33 11.5 8.7 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain FAM199X PF15814.5 CDI82349.1 - 0.017 14.2 4.0 0.022 13.8 4.0 1.1 1 0 0 1 1 1 0 Protein family FAM199X Spt20 PF12090.8 CDI82349.1 - 0.039 13.5 27.4 0.046 13.3 27.4 1.1 1 0 0 1 1 1 0 Spt20 family CNDH2_C PF16858.5 CDI82349.1 - 0.064 13.1 13.5 0.065 13.1 13.5 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC37_N PF03234.14 CDI82349.1 - 0.067 14.1 10.4 0.072 14.0 10.4 1.1 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Pex14_N PF04695.13 CDI82349.1 - 0.09 13.4 12.0 0.12 13.1 12.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CIAPIN1 PF05093.13 CDI82349.1 - 0.092 13.3 4.7 0.13 12.8 4.7 1.3 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis FAM91_C PF14648.6 CDI82349.1 - 0.16 10.7 5.9 0.17 10.7 5.9 1.1 1 0 0 1 1 1 0 FAM91 C-terminus DUF702 PF05142.12 CDI82349.1 - 0.25 11.8 13.1 0.31 11.5 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) TFIIA PF03153.13 CDI82349.1 - 0.26 11.3 28.8 0.27 11.2 28.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI82349.1 - 0.28 9.8 36.7 0.3 9.7 36.7 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI82349.1 - 0.3 10.0 20.9 0.32 9.9 20.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2368 PF10166.9 CDI82349.1 - 0.32 10.6 17.8 0.38 10.4 17.8 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) EIF4E-T PF10477.9 CDI82349.1 - 0.32 9.8 13.3 0.33 9.7 13.3 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Membralin PF09746.9 CDI82349.1 - 0.41 9.6 6.7 0.46 9.5 6.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein Activator_LAG-3 PF11498.8 CDI82349.1 - 0.61 9.0 36.5 0.7 8.8 36.5 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FAM176 PF14851.6 CDI82349.1 - 0.75 9.5 6.8 1 9.0 6.8 1.2 1 0 0 1 1 1 0 FAM176 family Spore_III_AF PF09581.10 CDI82349.1 - 0.75 9.8 10.4 0.8 9.7 10.4 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF4746 PF15928.5 CDI82349.1 - 0.9 8.9 7.9 0.92 8.9 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CAML PF14963.6 CDI82349.1 - 1 9.4 7.7 1.1 9.3 7.7 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand TERB2 PF15101.6 CDI82349.1 - 1.1 9.3 15.4 1.2 9.1 15.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Sec62 PF03839.16 CDI82349.1 - 1.1 8.7 8.2 1.2 8.6 8.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 CDI82349.1 - 1.1 8.9 8.1 1.2 8.8 8.1 1.1 1 0 0 1 1 1 0 Connexin SKA1 PF07160.12 CDI82349.1 - 1.1 9.0 13.6 1.3 8.9 13.6 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 eIF-3_zeta PF05091.12 CDI82349.1 - 1.2 8.0 14.8 1.3 7.9 14.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Adeno_PV PF03910.13 CDI82349.1 - 1.3 7.7 13.8 1.3 7.6 13.8 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV FliP PF00813.20 CDI82349.1 - 1.6 8.5 8.5 1.8 8.4 8.5 1.1 1 0 0 1 1 1 0 FliP family PPP4R2 PF09184.11 CDI82349.1 - 1.9 8.0 10.0 2.1 7.9 10.0 1.0 1 0 0 1 1 1 0 PPP4R2 Band_3_cyto PF07565.13 CDI82349.1 - 2.1 8.1 11.2 2.3 7.9 11.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NACHT_N PF17100.5 CDI82349.1 - 2.5 7.9 16.6 2.7 7.8 16.6 1.0 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase RIFIN PF02009.16 CDI82349.1 - 2.6 7.8 15.9 3 7.7 15.9 1.1 1 0 0 1 1 1 0 Rifin Bud13 PF09736.9 CDI82349.1 - 2.7 8.4 16.2 3.1 8.2 16.2 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex GET2 PF08690.10 CDI82349.1 - 2.8 7.5 15.9 3 7.4 15.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 CemA PF03040.14 CDI82349.1 - 3 7.7 8.3 3.3 7.6 8.3 1.0 1 0 0 1 1 1 0 CemA family Lin-8 PF03353.15 CDI82349.1 - 3.1 7.3 15.9 3.2 7.2 15.9 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist EPL1 PF10513.9 CDI82349.1 - 3.5 8.0 11.7 3.9 7.8 11.7 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like PPL5 PF18168.1 CDI82349.1 - 3.6 6.8 12.0 3.9 6.7 12.0 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Neur_chan_memb PF02932.16 CDI82349.1 - 3.7 7.6 10.0 4.1 7.4 10.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 CDI82349.1 - 3.7 5.8 7.2 4 5.7 7.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1764 PF08576.10 CDI82349.1 - 4 8.4 13.0 5.3 8.0 12.9 1.3 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) NST1 PF13945.6 CDI82349.1 - 4.2 7.4 18.8 4.6 7.3 18.8 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator CPSF100_C PF13299.6 CDI82349.1 - 4.6 7.4 14.3 5.4 7.2 14.3 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 CDI82349.1 - 4.6 6.0 10.4 4.8 5.9 10.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 CDI82349.1 - 4.7 7.2 9.4 5 7.1 9.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Cellulose_synt PF03552.14 CDI82349.1 - 5.1 5.5 5.4 5 5.5 5.4 1.0 1 0 0 1 1 1 0 Cellulose synthase GREB1 PF15782.5 CDI82349.1 - 5.5 4.0 14.4 5.9 3.9 14.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MDM10 PF12519.8 CDI82349.1 - 6 5.6 10.1 6 5.6 10.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF1980 PF09323.10 CDI82349.1 - 6.2 6.7 9.2 6.8 6.6 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) UPF0560 PF10577.9 CDI82349.1 - 6.3 5.2 17.8 6.9 5.0 17.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SLC12 PF03522.15 CDI82349.1 - 6.7 5.6 14.2 7 5.6 14.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 CDI82349.1 - 6.8 4.7 12.8 6.6 4.7 12.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MAJIN PF15077.6 CDI82349.1 - 6.9 6.4 8.6 7.5 6.3 8.6 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Gti1_Pac2 PF09729.9 CDI82349.1 - 7.4 6.6 11.3 8.7 6.4 11.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family RR_TM4-6 PF06459.12 CDI82349.1 - 7.7 6.3 13.5 8.4 6.1 13.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 CDI82349.1 - 8.1 5.4 9.5 9 5.2 9.5 1.1 1 0 0 1 1 1 0 CLN3 protein HCO3_cotransp PF00955.21 CDI82349.1 - 8.4 5.1 5.9 8.6 5.0 5.9 1.0 1 0 0 1 1 1 0 HCO3- transporter family V_ATPase_I PF01496.19 CDI82349.1 - 8.6 4.1 13.3 10 3.9 13.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDHD PF02862.17 CDI82349.1 - 9.3 6.3 11.0 11 6.2 11.0 1.2 1 0 0 1 1 1 0 DDHD domain DUF3533 PF12051.8 CDI82349.1 - 9.3 5.1 9.8 9.8 5.0 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Presenilin PF01080.17 CDI82349.1 - 9.3 4.9 16.9 10 4.7 16.9 1.0 1 0 0 1 1 1 0 Presenilin Abi_2 PF07751.11 CDI82350.1 - 0.044 14.0 1.4 0.057 13.7 1.4 1.1 1 0 0 1 1 1 0 Abi-like protein STELLO PF03385.17 CDI82350.1 - 0.057 12.2 10.7 0.071 11.9 10.7 1.0 1 0 0 1 1 1 0 STELLO glycosyltransferases DUF4638 PF15472.6 CDI82350.1 - 0.071 12.8 15.6 0.079 12.7 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Sec62 PF03839.16 CDI82350.1 - 0.15 11.5 16.3 0.18 11.3 16.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Gti1_Pac2 PF09729.9 CDI82350.1 - 0.42 10.7 12.9 0.49 10.5 12.9 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.17 CDI82350.1 - 0.44 9.3 20.1 0.48 9.1 20.1 1.0 1 0 0 1 1 1 0 Presenilin Dehalogenase PF13486.6 CDI82350.1 - 0.46 9.8 7.6 0.62 9.4 7.6 1.2 1 0 0 1 1 1 0 Reductive dehalogenase subunit RR_TM4-6 PF06459.12 CDI82350.1 - 0.51 10.1 20.2 0.59 9.9 20.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 CDI82350.1 - 0.62 8.9 13.0 0.66 8.8 13.0 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SLC12 PF03522.15 CDI82350.1 - 0.65 9.0 17.4 0.73 8.8 17.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 CDI82350.1 - 0.77 8.0 16.3 0.81 7.9 16.3 1.0 1 0 0 1 1 1 0 CDC45-like protein PAT1 PF09770.9 CDI82350.1 - 0.78 7.9 29.4 0.85 7.8 29.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2407_C PF13373.6 CDI82350.1 - 0.86 9.8 11.9 1.1 9.4 11.9 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain Zip PF02535.22 CDI82350.1 - 0.87 8.7 7.4 1 8.5 7.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4770 PF15994.5 CDI82350.1 - 1.3 9.2 21.5 1.5 9.0 21.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) LicD PF04991.13 CDI82350.1 - 1.4 9.0 7.8 1.6 8.8 7.8 1.0 1 0 0 1 1 1 0 LicD family NPR3 PF03666.13 CDI82350.1 - 1.5 7.6 16.7 1.6 7.4 16.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Membralin PF09746.9 CDI82350.1 - 1.6 7.7 10.4 1.8 7.5 10.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein PTPRCAP PF15713.5 CDI82350.1 - 1.6 9.0 25.4 2.2 8.6 25.4 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2370 PF10176.9 CDI82350.1 - 2 8.0 5.9 2.3 7.8 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SID-1_RNA_chan PF13965.6 CDI82350.1 - 2.6 6.4 8.7 2.8 6.2 8.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Glyco_transf_41 PF13844.6 CDI82350.1 - 2.9 6.2 7.6 3.2 6.1 7.6 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 Neur_chan_memb PF02932.16 CDI82350.1 - 4.7 7.2 14.2 5.2 7.1 14.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paramyxo_ncap PF00973.19 CDI82350.1 - 5.4 5.8 12.4 5.7 5.7 12.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Peptidase_S64 PF08192.11 CDI82350.1 - 6.3 5.2 15.2 6.9 5.0 15.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 N6_N4_Mtase PF01555.18 CDI82350.1 - 7.6 6.2 9.0 9.5 5.9 9.0 1.3 1 0 0 1 1 1 0 DNA methylase DUF2052 PF09747.9 CDI82350.1 - 9.1 6.4 24.1 11 6.1 24.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ctr PF04145.15 CDI82352.1 - 0.093 13.3 0.9 32 5.1 2.7 2.2 2 0 0 2 2 2 0 Ctr copper transporter family CDC45 PF02724.14 CDI82352.1 - 0.16 10.3 2.3 0.17 10.2 2.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF3915 PF13054.6 CDI82352.1 - 0.24 11.4 1.3 0.38 10.7 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) SpoIIP PF07454.11 CDI82352.1 - 0.88 9.0 7.9 1.4 8.3 7.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Eapp_C PF10238.9 CDI82352.1 - 3.1 7.9 8.5 1.3 9.1 5.8 1.8 2 0 0 2 2 2 0 E2F-associated phosphoprotein Peptidase_S64 PF08192.11 CDI82352.1 - 3.9 5.8 5.8 5.9 5.3 5.8 1.2 1 0 0 1 1 1 0 Peptidase family S64 Plasmodium_Vir PF05795.11 CDI82352.1 - 4.2 6.7 5.7 6.3 6.1 5.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4175 PF13779.6 CDI82352.1 - 5.9 4.7 21.0 7.2 4.4 21.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ThiF PF00899.21 CDI82353.1 - 7.1e-53 179.5 0.0 2.7e-52 177.6 0.0 1.9 1 1 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 CDI82353.1 - 0.01 15.7 0.0 0.01 15.7 0.0 4.0 4 0 0 4 4 4 0 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 CDI82353.1 - 0.022 15.3 0.1 0.11 13.0 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain DUF2229 PF09989.9 CDI82353.1 - 0.3 10.7 0.0 0.3 10.7 0.0 2.3 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) MPC PF03650.13 CDI82353.1 - 1.1 9.4 3.7 0.4 10.8 0.3 2.0 2 0 0 2 2 2 0 Mitochondrial pyruvate carriers DUF4207 PF13904.6 CDI82355.1 - 0.0017 18.1 18.3 0.0017 18.1 18.3 4.2 2 2 2 4 4 4 1 Domain of unknown function (DUF4207) SSP160 PF06933.11 CDI82355.1 - 0.62 8.2 7.1 0.85 7.7 7.1 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF2126 PF09899.9 CDI82355.1 - 2 6.4 36.7 0.12 10.4 9.9 2.4 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) CRAL_TRIO_N PF03765.15 CDI82356.1 - 2.5e-06 27.5 1.8 2.5e-06 27.5 1.8 3.0 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain Velvet PF11754.8 CDI82356.1 - 0.0013 18.7 18.0 0.0013 18.7 18.0 2.1 2 0 0 2 2 2 2 Velvet factor CRT10 PF08728.10 CDI82356.1 - 1.8 6.6 19.0 2.7 6.1 19.0 1.2 1 0 0 1 1 1 0 CRT10 rRNA_processing PF08524.11 CDI82356.1 - 2.3 8.2 72.6 0.32 11.0 42.1 2.1 2 0 0 2 2 2 0 rRNA processing LRR_6 PF13516.6 CDI82357.1 - 8e-05 22.4 2.8 3.6 7.9 0.1 3.6 3 0 0 3 3 3 3 Leucine Rich repeat Spt20 PF12090.8 CDI82357.1 - 0.0045 16.6 7.8 0.0045 16.6 7.8 12.7 7 3 3 10 10 10 3 Spt20 family PGF-CTERM PF18204.1 CDI82360.1 - 1.1 9.3 4.4 3 7.9 4.4 1.8 1 0 0 1 1 1 0 PGF-CTERM motif CD20 PF04103.15 CDI82365.1 - 0.13 12.4 0.9 0.18 11.9 0.9 1.2 1 0 0 1 1 1 0 CD20-like family AIM3 PF17096.5 CDI82365.1 - 0.13 13.2 12.3 0.18 12.8 12.3 1.2 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 DcuA_DcuB PF03605.14 CDI82365.1 - 0.25 10.2 4.5 0.34 9.8 4.5 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter FHIPEP PF00771.20 CDI82365.1 - 0.3 9.5 7.4 0.3 9.5 7.4 1.1 1 0 0 1 1 1 0 FHIPEP family SID-1_RNA_chan PF13965.6 CDI82365.1 - 0.44 8.9 5.4 0.44 8.9 5.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ureide_permease PF07168.11 CDI82365.1 - 0.47 9.1 3.6 0.58 8.9 3.6 1.1 1 0 0 1 1 1 0 Ureide permease Maf1 PF09174.10 CDI82365.1 - 0.59 10.3 7.3 0.75 9.9 7.3 1.3 1 0 0 1 1 1 0 Maf1 regulator OATP PF03137.20 CDI82365.1 - 0.82 7.9 5.6 0.81 7.9 5.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 CDI82365.1 - 0.83 8.3 4.6 0.96 8.1 4.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier Band_3_cyto PF07565.13 CDI82365.1 - 1.1 9.0 13.8 1.3 8.7 13.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain BNR_3 PF13859.6 CDI82365.1 - 1.7 7.9 5.0 1.7 7.9 5.0 1.1 1 0 0 1 1 1 0 BNR repeat-like domain Serinc PF03348.15 CDI82365.1 - 1.9 7.3 7.1 1.8 7.4 7.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) V_ATPase_I PF01496.19 CDI82365.1 - 2 6.3 12.1 1.9 6.3 12.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 CDI82365.1 - 2 7.1 15.5 2.4 6.9 15.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AIF_C PF14721.6 CDI82365.1 - 2.6 8.4 13.6 0.52 10.7 9.9 1.6 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Zip PF02535.22 CDI82365.1 - 3 7.0 8.7 3.3 6.8 8.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 CDI82365.1 - 4.3 6.2 6.4 5 6.0 6.4 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 CDI82365.1 - 4.5 5.9 20.7 5.5 5.6 20.7 1.1 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.13 CDI82365.1 - 4.5 6.0 8.8 5 5.8 8.8 1.1 1 0 0 1 1 1 0 Otopetrin TFIIA PF03153.13 CDI82365.1 - 4.6 7.1 47.3 5.8 6.8 47.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CLN3 PF02487.17 CDI82365.1 - 5.3 6.0 9.7 5.4 6.0 9.7 1.2 1 0 0 1 1 1 0 CLN3 protein DUF2232 PF09991.9 CDI82365.1 - 6.3 5.9 7.3 11 5.1 7.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Peroxin-13_N PF04088.13 CDI82365.1 - 7 6.9 10.5 1.3 9.3 7.0 1.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region AUX_IAA PF02309.16 CDI82365.1 - 9.2 6.0 15.5 11 5.8 15.5 1.0 1 0 0 1 1 1 0 AUX/IAA family Membralin PF09746.9 CDI82365.1 - 9.5 5.1 9.7 11 5.0 9.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein Myosin_head PF00063.21 CDI82366.1 - 1.5e-28 99.5 0.0 2.1e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Prp31_C PF09785.9 CDI82370.1 - 1.2e-08 35.9 0.2 1.2e-08 35.9 0.2 2.1 2 1 0 2 2 2 1 Prp31 C terminal domain Lin-8 PF03353.15 CDI82370.1 - 0.19 11.2 4.6 0.23 11.0 4.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 CDI82370.1 - 0.28 11.1 8.6 0.36 10.7 8.6 1.1 1 0 0 1 1 1 0 SPX domain Peptidase_S64 PF08192.11 CDI82370.1 - 0.31 9.5 9.4 0.36 9.3 9.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 TFIIA PF03153.13 CDI82370.1 - 0.84 9.6 12.5 1 9.3 12.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Herpes_pp85 PF04637.12 CDI82370.1 - 0.95 7.8 7.0 1.1 7.6 7.0 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PAP1 PF08601.10 CDI82370.1 - 5.3 6.7 15.1 6.3 6.4 15.1 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 DUF1645 PF07816.11 CDI82372.1 - 0.0004 21.0 4.6 0.00054 20.6 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) MPM1 PF17234.2 CDI82372.1 - 0.017 15.4 7.0 0.022 15.0 7.0 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 LCD1 PF09798.9 CDI82372.1 - 0.021 13.4 3.7 0.018 13.6 3.7 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein TFIIA PF03153.13 CDI82372.1 - 0.022 14.8 21.4 0.025 14.6 21.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FUN14 PF04930.15 CDI82372.1 - 0.06 13.8 0.3 0.086 13.3 0.3 1.2 1 0 0 1 1 1 0 FUN14 family DUF2722 PF10846.8 CDI82372.1 - 0.13 11.2 21.3 0.16 10.8 21.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDI82372.1 - 0.15 10.8 5.1 0.19 10.5 5.1 1.2 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 CDI82372.1 - 0.23 8.5 9.6 0.25 8.4 9.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 CDI82372.1 - 0.25 10.9 9.7 0.31 10.6 9.7 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Med15 PF09606.10 CDI82372.1 - 0.26 9.9 22.4 0.27 9.9 22.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal FAM150 PF15129.6 CDI82372.1 - 0.31 11.2 7.1 0.5 10.5 7.1 1.3 1 1 0 1 1 1 0 FAM150 family Plasmodium_Vir PF05795.11 CDI82372.1 - 0.95 8.8 5.6 1.2 8.5 5.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Miga PF10265.9 CDI82372.1 - 1.3 8.0 9.5 1.5 7.7 9.5 1.0 1 0 0 1 1 1 0 Mitoguardin DivIC PF04977.15 CDI82372.1 - 1.8 8.4 16.6 3.8 7.3 16.6 1.5 1 0 0 1 1 1 0 Septum formation initiator Androgen_recep PF02166.16 CDI82372.1 - 5.5 5.7 26.1 7 5.4 26.1 1.2 1 0 0 1 1 1 0 Androgen receptor Acetyltransf_1 PF00583.25 CDI82373.1 - 2.6e-17 63.1 0.0 3.4e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDI82373.1 - 8.4e-12 45.4 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDI82373.1 - 1.5e-11 44.3 0.0 2.4e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDI82373.1 - 1.1e-05 26.2 0.0 1.3e-05 25.8 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDI82373.1 - 2.8e-05 24.2 0.1 0.00011 22.3 0.0 1.9 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CDI82373.1 - 4.3e-05 23.4 0.0 7.1e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDI82373.1 - 0.0082 16.2 0.0 0.022 14.8 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CDI82373.1 - 0.06 13.0 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4471 PF14740.6 CDI82374.1 - 0.015 14.5 3.8 0.027 13.7 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) DUF4770 PF15994.5 CDI82374.1 - 0.086 13.1 9.9 0.15 12.3 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF4834 PF16118.5 CDI82374.1 - 0.21 12.6 15.4 2.6 9.1 14.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DDRGK PF09756.9 CDI82374.1 - 0.51 9.9 15.6 0.85 9.2 15.6 1.3 1 0 0 1 1 1 0 DDRGK domain DNApol_Exo PF18136.1 CDI82374.1 - 0.7 9.0 10.2 1.6 7.8 10.2 1.5 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF775 PF05603.12 CDI82374.1 - 0.7 9.4 17.0 0.32 10.5 8.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF775) Connexin PF00029.19 CDI82374.1 - 0.96 9.2 6.4 1.6 8.4 6.4 1.3 1 0 0 1 1 1 0 Connexin DUF4518 PF15008.6 CDI82374.1 - 1 8.5 11.9 0.4 9.8 9.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) SpoIIP PF07454.11 CDI82374.1 - 1 8.8 12.4 0.46 9.9 8.4 1.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF4638 PF15472.6 CDI82374.1 - 1.2 8.8 10.4 1.9 8.1 7.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) MMR1 PF08505.10 CDI82374.1 - 1.4 9.2 18.2 0.13 12.6 8.2 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein TERB2 PF15101.6 CDI82374.1 - 1.5 8.8 16.5 4.3 7.3 16.5 1.7 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI82374.1 - 2 7.3 16.1 3.8 6.4 16.1 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) V_ATPase_I PF01496.19 CDI82374.1 - 2.1 6.2 9.8 3.1 5.6 9.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 CDI82374.1 - 2.1 7.3 10.3 0.15 11.1 4.9 1.7 2 0 0 2 2 2 0 Solute carrier family 12 FAM150 PF15129.6 CDI82374.1 - 2.6 8.2 10.2 6.3 7.0 10.2 1.7 1 0 0 1 1 1 0 FAM150 family Spt20 PF12090.8 CDI82374.1 - 3.6 7.1 36.9 1.6 8.3 34.4 1.6 2 0 0 2 2 2 0 Spt20 family Peptidase_S49_N PF08496.10 CDI82374.1 - 4.9 7.2 9.8 10 6.1 9.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Folate_carrier PF01770.18 CDI82374.1 - 5 5.7 6.7 8.5 5.0 6.7 1.3 1 0 0 1 1 1 0 Reduced folate carrier WRNPLPNID PF15017.6 CDI82374.1 - 5.5 7.9 11.8 1.3 9.9 7.6 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box FAM176 PF14851.6 CDI82374.1 - 6.4 6.4 11.6 0.93 9.1 6.4 2.0 2 0 0 2 2 2 0 FAM176 family OATP PF03137.20 CDI82374.1 - 7 4.8 7.0 2.2 6.5 4.3 1.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Rib_recp_KP_reg PF05104.12 CDI82374.1 - 8.2 7.4 31.2 0.85 10.7 17.3 2.3 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Presenilin PF01080.17 CDI82374.1 - 9.4 4.9 16.7 0.13 11.0 7.8 1.9 2 0 0 2 2 2 0 Presenilin YABBY PF04690.13 CDI82374.1 - 9.8 6.7 11.9 0.61 10.6 5.6 2.1 2 1 0 2 2 2 0 YABBY protein Spt20 PF12090.8 CDI82376.1 - 0.0032 17.1 14.4 0.0032 17.1 14.4 1.8 2 0 0 2 2 2 1 Spt20 family DUF3381 PF11861.8 CDI82376.1 - 0.016 15.0 4.7 0.016 15.0 4.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) MPM1 PF17234.2 CDI82376.1 - 0.042 14.1 4.7 0.071 13.4 4.7 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 TERB2 PF15101.6 CDI82376.1 - 0.14 12.2 9.2 0.089 12.8 6.5 1.9 2 0 0 2 2 2 0 Telomere-associated protein TERB2 EIF4E-T PF10477.9 CDI82376.1 - 0.18 10.6 10.5 0.22 10.3 10.5 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E MMU163 PF17119.5 CDI82376.1 - 1.8 7.6 6.0 0.18 10.9 0.8 1.8 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis DUF1764 PF08576.10 CDI82376.1 - 2.4 9.1 7.1 0.33 11.9 1.1 2.4 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) MMR1 PF08505.10 CDI82376.1 - 3.2 8.0 10.7 0.23 11.7 5.4 1.7 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF4834 PF16118.5 CDI82376.1 - 4.1 8.4 9.4 4 8.5 7.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Band_3_cyto PF07565.13 CDI82376.1 - 4.4 7.0 9.0 71 3.1 9.7 2.2 1 1 0 2 2 2 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI82376.1 - 4.5 5.9 12.7 0.77 8.5 3.4 2.1 2 0 0 2 2 2 0 Presenilin Peptidase_M24 PF00557.24 CDI82377.1 - 1.7e-34 119.3 0.0 2.6e-34 118.7 0.0 1.4 1 1 0 1 1 1 1 Metallopeptidase family M24 Apt1 PF10351.9 CDI82378.1 - 6.2e-05 22.0 4.0 6.2e-05 22.0 4.0 5.2 3 2 0 3 3 3 1 Golgi-body localisation protein domain SPX PF03105.19 CDI82378.1 - 0.0016 18.5 5.6 0.0016 18.5 5.6 6.2 2 1 1 3 3 3 1 SPX domain FtsX PF02687.21 CDI82378.1 - 0.25 11.9 9.1 0.24 11.9 1.8 3.5 2 0 0 2 2 2 0 FtsX-like permease family DMSP_lyase PF16867.5 CDI82380.1 - 0.02 14.5 2.5 0.037 13.7 2.5 1.4 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase SART-1 PF03343.13 CDI82380.1 - 0.07 11.7 4.2 0.083 11.4 4.2 1.1 1 0 0 1 1 1 0 SART-1 family PAT1 PF09770.9 CDI82380.1 - 0.26 9.5 12.2 0.28 9.4 12.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI82380.1 - 0.62 10.0 30.8 0.81 9.6 30.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOBP PF15279.6 CDI82380.1 - 5.6 7.5 13.8 3.8 8.0 11.7 1.6 1 1 1 2 2 2 0 Sine oculis-binding protein GATase PF00117.28 CDI82381.1 - 0.015 15.1 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 Glutamine amidotransferase class-I Cloacin PF03515.14 CDI82381.1 - 0.041 13.6 0.8 0.043 13.5 0.8 1.1 1 0 0 1 1 1 0 Colicin-like bacteriocin tRNase domain DUF1635 PF07795.11 CDI82381.1 - 0.3 10.9 1.9 0.32 10.8 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Macoilin PF09726.9 CDI82381.1 - 0.36 9.3 3.9 0.32 9.5 3.9 1.0 1 0 0 1 1 1 0 Macoilin family SUZ PF12752.7 CDI82381.1 - 4.5 8.1 6.4 7.4 7.4 6.4 1.4 1 0 0 1 1 1 0 SUZ domain DUF1635 PF07795.11 CDI82382.1 - 0.0024 17.7 3.9 0.0024 17.7 3.9 3.1 2 1 0 3 3 3 1 Protein of unknown function (DUF1635) SUIM_assoc PF16619.5 CDI82382.1 - 0.049 13.7 0.7 0.049 13.7 0.7 3.5 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI82382.1 - 0.14 11.7 16.5 0.75 9.4 0.6 2.2 2 0 0 2 2 2 0 Spt20 family Requiem_N PF14051.6 CDI82382.1 - 2.4 8.4 5.6 0.31 11.3 1.2 1.7 2 0 0 2 2 2 0 N-terminal domain of DPF2/REQ. Pap_E4 PF02711.14 CDI82382.1 - 5.2 8.1 7.3 11 7.1 0.6 3.1 3 0 0 3 3 3 0 E4 protein DnaJ PF00226.31 CDI82386.1 - 2e-09 37.4 0.4 3.4e-09 36.7 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain DUF3638 PF12340.8 CDI82388.1 - 5.3e-21 75.0 0.1 5.2e-17 61.9 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF2722 PF10846.8 CDI82388.1 - 0.0036 16.3 0.3 0.0036 16.3 0.3 9.0 9 0 0 9 9 9 5 Protein of unknown function (DUF2722) EF-hand_6 PF13405.6 CDI82389.1 - 1.2e-05 24.8 0.2 0.22 11.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CDI82389.1 - 2.2e-05 24.8 0.1 6.6e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CDI82389.1 - 0.00029 20.2 0.1 0.041 13.4 0.2 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 CDI82389.1 - 0.06 12.9 0.2 0.14 11.7 0.2 1.7 1 0 0 1 1 1 0 EF hand BURP PF03181.15 CDI82389.1 - 4.1 6.9 5.7 9.9 5.7 5.7 1.7 1 0 0 1 1 1 0 BURP domain Enolase_C PF00113.22 CDI82390.1 - 9.5e-134 445.3 0.2 1.2e-133 444.9 0.2 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CDI82390.1 - 1e-39 135.7 0.1 1.7e-39 135.0 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CDI82390.1 - 8.5e-12 45.1 0.0 1.3e-11 44.5 0.0 1.4 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDI82390.1 - 1.9e-06 27.2 0.1 3.3e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus tRNA_synthFbeta PF17759.1 CDI82391.1 - 1.6e-24 86.5 0.0 2.5e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 CDI82391.1 - 6.6e-09 35.9 0.0 2.3e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 CDI82391.1 - 0.00023 20.9 0.0 0.0006 19.5 0.0 1.7 1 0 0 1 1 1 1 B3/4 domain Pro-rich PF15240.6 CDI82394.1 - 0.015 15.6 34.4 0.02 15.2 34.4 1.2 1 0 0 1 1 1 0 Proline-rich Pkinase PF00069.25 CDI82397.1 - 2e-15 56.9 0.0 2.8e-13 49.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.6 CDI82397.1 - 3.7e-05 23.2 0.0 0.0015 17.9 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Pkinase_Tyr PF07714.17 CDI82397.1 - 4.1e-05 23.0 0.1 0.00017 21.0 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CDI82397.1 - 0.058 12.7 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIA PF03153.13 CDI82400.1 - 0.24 11.3 33.0 0.32 10.9 33.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Casc1 PF12366.8 CDI82401.1 - 0.021 14.3 0.0 0.026 14.0 0.0 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 CCDC24 PF15669.5 CDI82401.1 - 0.093 12.6 0.3 0.13 12.1 0.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Kinesin PF00225.23 CDI82403.1 - 1.1e-75 254.7 5.1 1.5e-54 185.2 0.0 3.0 2 1 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 CDI82403.1 - 7.9e-21 74.6 0.4 4.2e-20 72.2 0.4 2.3 1 1 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 CDI82403.1 - 1.9e-06 28.2 0.4 0.00067 20.0 0.0 3.5 2 0 0 2 2 2 1 Kinesin protein 1B Kinesin_assoc PF16183.5 CDI82403.1 - 0.0016 18.6 1.0 0.0016 18.6 1.0 4.6 3 2 1 4 4 4 2 Kinesin-associated FHA PF00498.26 CDI82403.1 - 0.025 14.9 0.0 0.076 13.4 0.0 1.8 1 0 0 1 1 1 0 FHA domain DUF4250 PF14056.6 CDI82403.1 - 0.036 14.0 0.1 0.036 14.0 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) AAA_22 PF13401.6 CDI82403.1 - 2.1 8.6 6.2 17 5.7 0.0 3.9 3 1 0 3 3 3 0 AAA domain Ion_trans PF00520.31 CDI82404.1 - 9.9e-30 103.5 55.9 1.6e-15 57.0 15.6 4.1 4 0 0 4 4 4 4 Ion transport protein WD40 PF00400.32 CDI82406.1 - 0.00017 22.3 10.0 2.4 9.1 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI82406.1 - 0.013 15.8 0.0 7.4 6.9 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1525 PF07511.11 CDI82408.1 - 0.035 14.2 2.1 0.073 13.2 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) YwqJ-deaminase PF14431.6 CDI82408.1 - 0.1 12.8 0.6 0.29 11.3 0.6 1.7 1 0 0 1 1 1 0 YwqJ-like deaminase KfrA_N PF11740.8 CDI82409.1 - 0.0019 18.8 19.9 0.0019 18.8 19.9 7.0 4 1 3 7 7 7 1 Plasmid replication region DNA-binding N-term Myosin_head PF00063.21 CDI82412.1 - 5.3e-18 64.6 0.2 7.1e-18 64.2 0.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Coilin_N PF15862.5 CDI82413.1 - 0.00058 19.7 0.0 0.022 14.5 0.0 2.9 3 1 0 3 3 3 1 Coilin N-terminus MAGE_N PF12440.8 CDI82413.1 - 0.018 15.7 10.7 0.018 15.7 10.7 3.9 3 1 0 3 3 2 0 Melanoma associated antigen family N terminal TFIIA PF03153.13 CDI82413.1 - 0.028 14.5 14.3 0.044 13.8 14.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI82413.1 - 0.028 14.1 10.4 0.097 12.3 2.1 2.3 2 0 0 2 2 2 0 Spt20 family EIIBC-GUT_N PF03612.14 CDI82413.1 - 0.52 10.0 3.4 4.7 6.9 0.0 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Med3 PF11593.8 CDI82413.1 - 1 8.5 17.0 0.85 8.7 1.0 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal G0-G1_switch_2 PF15103.6 CDI82413.1 - 1.6 9.2 5.4 1.5 9.3 0.8 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 MAS20 PF02064.15 CDI82413.1 - 1.9 8.6 9.8 3.8 7.6 4.2 2.5 2 0 0 2 2 2 0 MAS20 protein import receptor DUF3306 PF11748.8 CDI82413.1 - 3.5 8.5 14.6 3.1 8.7 6.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Hep_59 PF07052.11 CDI82413.1 - 4 8.2 10.6 0.57 11.0 2.4 2.7 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 SUIM_assoc PF16619.5 CDI82413.1 - 4.6 7.4 29.8 0.27 11.3 9.5 3.1 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Ndc1_Nup PF09531.10 CDI82413.1 - 4.9 5.7 9.1 6.6 5.3 9.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CCSAP PF15748.5 CDI82414.1 - 0.0094 16.2 6.7 0.014 15.6 6.7 1.3 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated AUX_IAA PF02309.16 CDI82414.1 - 0.044 13.6 1.3 0.063 13.1 1.3 1.1 1 0 0 1 1 1 0 AUX/IAA family Dsh_C PF12316.8 CDI82414.1 - 0.061 13.7 11.8 0.1 13.0 11.8 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF218 PF02698.17 CDI82414.1 - 0.089 12.8 0.2 2.6 8.1 0.0 2.1 1 1 1 2 2 2 0 DUF218 domain SDA1 PF05285.12 CDI82414.1 - 0.14 11.5 7.2 0.16 11.4 7.2 1.1 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 CDI82414.1 - 0.39 9.4 3.8 0.56 8.9 3.8 1.2 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI82414.1 - 0.54 9.1 3.9 0.57 9.0 3.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PPP4R2 PF09184.11 CDI82414.1 - 1.2 8.7 10.4 1.6 8.3 10.4 1.1 1 0 0 1 1 1 0 PPP4R2 Raftlin PF15250.6 CDI82414.1 - 1.2 7.8 4.3 1.3 7.7 4.3 1.1 1 0 0 1 1 1 0 Raftlin SMC_N PF02463.19 CDI82422.1 - 1.9e-17 63.5 3.1 2.5e-17 63.1 3.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDI82422.1 - 7.8e-10 39.0 0.1 7.9e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SUIM_assoc PF16619.5 CDI82422.1 - 0.00023 21.1 3.1 0.00023 21.1 3.1 4.5 2 1 1 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 SbcCD_C PF13558.6 CDI82422.1 - 0.0054 16.9 0.1 0.0054 16.9 0.1 2.5 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 CDI82422.1 - 0.015 15.0 7.6 0.022 14.5 7.6 1.1 1 0 0 1 1 1 0 AAA ATPase domain Leu_zip PF15294.6 CDI82422.1 - 0.37 10.3 21.2 0.036 13.6 7.4 2.1 2 0 0 2 2 2 0 Leucine zipper Uds1 PF15456.6 CDI82422.1 - 0.42 10.8 20.4 1.1 9.4 20.4 1.6 1 1 0 1 1 1 0 Up-regulated During Septation FlaC_arch PF05377.11 CDI82422.1 - 0.65 10.4 3.4 1.3 9.5 1.1 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) PAT1 PF09770.9 CDI82422.1 - 1.3 7.2 27.3 1.6 6.9 27.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 STI1 PF17830.1 CDI82423.1 - 4.9e-05 23.2 4.5 0.00037 20.4 1.0 1.9 1 1 1 2 2 2 2 STI1 domain GerD PF17898.1 CDI82423.1 - 0.0019 18.1 0.0 0.0025 17.8 0.0 1.1 1 0 0 1 1 1 1 Spore germination GerD central core domain Methyltransf_7 PF03492.15 CDI82423.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase ketoacyl-synt PF00109.26 CDI82427.1 - 2.7e-64 217.2 0.0 7.7e-64 215.7 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CDI82427.1 - 1.5e-49 168.4 0.2 5.7e-49 166.5 0.1 2.1 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 CDI82427.1 - 3.2e-44 151.7 3.4 1.1e-37 130.2 1.6 2.3 1 1 1 2 2 2 2 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CDI82427.1 - 1.2e-31 109.2 0.1 3.7e-31 107.6 0.1 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 CDI82427.1 - 2.7e-29 102.1 0.0 1.2e-26 93.4 0.0 2.7 3 0 0 3 3 3 2 Male sterility protein PP-binding PF00550.25 CDI82427.1 - 7.4e-10 39.0 0.5 2e-09 37.6 0.5 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CDI82427.1 - 9.1e-10 38.3 0.0 1.9e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDI82427.1 - 2.8e-07 30.3 0.1 8.5e-07 28.8 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CDI82427.1 - 3.7e-05 23.0 0.0 0.00093 18.4 0.0 2.8 3 1 0 3 3 3 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CDI82427.1 - 3.8e-05 23.3 0.3 0.013 14.9 0.0 2.9 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family KAsynt_C_assoc PF16197.5 CDI82427.1 - 0.00052 20.5 0.0 0.0029 18.0 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension GDP_Man_Dehyd PF16363.5 CDI82427.1 - 0.0014 18.1 0.0 0.0033 16.9 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Syntaxin-6_N PF09177.11 CDI82429.1 - 3.2e-19 69.3 10.0 3.3e-18 66.0 1.8 2.2 2 0 0 2 2 2 2 Syntaxin 6, N-terminal Nup88 PF10168.9 CDI82429.1 - 0.025 12.4 9.6 0.034 12.0 9.6 1.2 1 0 0 1 1 1 0 Nuclear pore component BLOC1_2 PF10046.9 CDI82429.1 - 0.088 13.1 10.3 0.11 12.8 0.1 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Deltameth_res PF16020.5 CDI82429.1 - 0.1 12.5 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 Deltamethrin resistance CheW PF01584.19 CDI82429.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 CheW-like domain Atg14 PF10186.9 CDI82429.1 - 1.3 8.1 9.2 2.1 7.4 9.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 CDI82429.1 - 2.5 7.3 9.6 4.5 6.4 3.3 2.1 2 0 0 2 2 2 0 TMPIT-like protein Herpes_capsid PF06112.11 CDI82429.1 - 4.3 7.4 12.7 9.6 6.2 12.7 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein ATG16 PF08614.11 CDI82429.1 - 8.2 6.6 25.5 0.93 9.7 10.8 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Spt20 PF12090.8 CDI82430.1 - 8.1 6.0 22.1 0.9 9.1 12.7 2.1 2 0 0 2 2 2 0 Spt20 family WD40 PF00400.32 CDI82431.1 - 5.6e-10 39.7 0.3 0.0011 19.7 0.0 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat SUIM_assoc PF16619.5 CDI82431.1 - 0.016 15.3 25.0 0.77 9.9 0.5 3.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI82431.1 - 0.2 11.2 21.1 2.3 7.8 14.3 2.5 2 0 0 2 2 2 0 Spt20 family SPX PF03105.19 CDI82431.1 - 0.47 10.3 18.2 92 2.8 18.2 2.9 1 1 0 1 1 1 0 SPX domain T6SS-SciN PF12790.7 CDI82431.1 - 0.49 10.1 7.3 0.17 11.6 0.2 3.0 2 1 1 3 3 3 0 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 DUF4171 PF13775.6 CDI82431.1 - 4.4 7.8 22.2 19 5.7 0.7 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4171) Spuma_A9PTase PF03539.14 CDI82432.1 - 0.00091 19.4 2.5 0.00091 19.4 2.5 2.1 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) DUF2052 PF09747.9 CDI82432.1 - 2.1 8.4 16.3 0.62 10.2 7.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SR-25 PF10500.9 CDI82433.1 - 0.0018 17.9 11.7 0.0018 17.9 11.7 3.7 3 1 1 4 4 4 2 Nuclear RNA-splicing-associated protein RPOL_N PF14700.6 CDI82433.1 - 0.075 12.4 0.1 0.075 12.4 0.1 3.1 3 0 0 3 3 3 0 DNA-directed RNA polymerase N-terminal ASD2 PF08687.11 CDI82433.1 - 0.38 10.3 33.8 1.3 8.5 6.8 3.2 3 0 0 3 3 3 0 Apx/Shroom domain ASD2 Zip PF02535.22 CDI82433.1 - 2 7.6 25.7 2.4 7.3 7.4 3.2 3 0 0 3 3 3 0 ZIP Zinc transporter SpoIIP PF07454.11 CDI82433.1 - 3.1 7.2 29.5 16 4.8 0.0 3.2 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Lin-8 PF03353.15 CDI82433.1 - 4 6.9 48.6 0.15 11.6 3.8 3.3 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist CNDH2_C PF16858.5 CDI82433.1 - 5.5 6.8 32.8 4.5 7.1 14.0 3.1 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PIP5K PF01504.18 CDI82434.1 - 3.2e-22 79.0 0.0 3.9e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase AAA_lid_9 PF17871.1 CDI82435.1 - 3e-23 81.7 0.3 6.3e-23 80.7 0.3 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_2 PF07724.14 CDI82435.1 - 4.3e-16 59.5 0.0 9.6e-16 58.4 0.0 1.6 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 CDI82435.1 - 0.00021 20.6 0.2 0.00051 19.4 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin Torsin PF06309.11 CDI82435.1 - 0.00022 21.3 0.0 0.00043 20.4 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA_16 PF13191.6 CDI82435.1 - 0.00051 20.5 0.3 0.0013 19.2 0.0 1.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 CDI82435.1 - 0.00066 20.2 0.2 0.003 18.1 0.0 2.1 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CDI82435.1 - 0.0017 18.1 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 CDI82435.1 - 0.0021 18.5 0.0 0.0044 17.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 CDI82435.1 - 0.0068 16.3 0.1 0.34 10.7 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein DNA_pol3_delta2 PF13177.6 CDI82435.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit MbeB_N PF04837.12 CDI82435.1 - 0.019 15.3 0.6 0.46 10.8 0.0 3.0 3 0 0 3 3 3 0 MbeB-like, N-term conserved region Roc PF08477.13 CDI82435.1 - 0.019 15.1 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 CDI82435.1 - 0.021 14.6 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 CDI82435.1 - 0.023 13.9 0.1 0.045 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 CDI82435.1 - 0.038 13.9 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CDI82435.1 - 0.04 14.2 0.1 0.85 9.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CDI82435.1 - 0.045 14.3 0.1 0.15 12.5 0.0 1.9 2 1 0 2 2 2 0 ABC transporter RuvB_N PF05496.12 CDI82435.1 - 0.05 13.3 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CDI82435.1 - 0.076 13.2 0.1 0.43 10.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain Homeodomain PF00046.29 CDI82435.1 - 0.082 12.8 0.1 0.29 11.0 0.1 2.0 1 0 0 1 1 1 0 Homeodomain Hpr_kinase_C PF07475.12 CDI82435.1 - 0.094 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_5 PF07728.14 CDI82435.1 - 0.096 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CDI82435.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 CDI82435.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 CDI82435.1 - 0.14 12.2 0.1 1 9.4 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain Brix PF04427.18 CDI82438.1 - 3.1e-25 89.4 0.1 6.7e-25 88.3 0.1 1.6 1 0 0 1 1 1 1 Brix domain SET PF00856.28 CDI82440.1 - 1e-09 39.0 0.0 1.4e-08 35.3 0.0 2.3 1 1 0 1 1 1 1 SET domain CTNNBL PF08216.11 CDI82440.1 - 0.5 10.6 2.2 1.5 9.1 0.6 2.6 3 1 0 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear Mon1 PF03164.14 CDI82441.1 - 1.9e-46 159.0 0.0 2.3e-45 155.4 0.0 1.9 1 1 0 1 1 1 1 Trafficking protein Mon1 Adenyl_transf PF04439.12 CDI82443.1 - 0.063 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Streptomycin adenylyltransferase DUF4259 PF14078.6 CDI82443.1 - 0.33 11.7 4.5 0.75 10.5 4.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) DUF2722 PF10846.8 CDI82450.1 - 0.00017 20.7 11.0 0.00018 20.6 11.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF3570 PF12094.8 CDI82450.1 - 0.00029 19.8 0.3 0.00029 19.8 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3570) Suf PF05843.14 CDI82450.1 - 0.00055 20.0 4.9 0.00067 19.7 4.9 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Pex14_N PF04695.13 CDI82450.1 - 0.0022 18.7 8.9 0.003 18.2 8.9 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI82450.1 - 0.0024 18.0 15.2 0.0025 17.9 15.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF5102 PF17104.5 CDI82450.1 - 0.0051 16.9 3.3 0.0063 16.6 3.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) EPL1 PF10513.9 CDI82450.1 - 0.012 16.0 2.6 0.014 15.7 2.6 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like eIF-3_zeta PF05091.12 CDI82450.1 - 0.018 14.1 4.9 0.018 14.1 4.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDHD PF02862.17 CDI82450.1 - 0.02 15.0 1.1 0.02 15.1 1.1 1.1 1 0 0 1 1 1 0 DDHD domain AIF_C PF14721.6 CDI82450.1 - 0.029 14.7 1.7 0.04 14.3 1.7 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Presenilin PF01080.17 CDI82450.1 - 0.033 13.0 3.3 0.032 13.0 3.3 1.1 1 0 0 1 1 1 0 Presenilin Ribosomal_S10 PF00338.22 CDI82450.1 - 0.034 14.4 2.0 0.29 11.4 2.7 1.9 2 0 0 2 2 2 0 Ribosomal protein S10p/S20e LMBR1 PF04791.16 CDI82450.1 - 0.037 12.9 2.8 0.04 12.8 2.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4638 PF15472.6 CDI82450.1 - 0.051 13.3 4.7 0.063 13.0 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Paramyxo_ncap PF00973.19 CDI82450.1 - 0.15 10.9 3.8 0.17 10.8 3.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF3408 PF11888.8 CDI82450.1 - 0.24 11.5 8.7 0.31 11.2 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) DUF4175 PF13779.6 CDI82450.1 - 0.25 9.2 14.2 0.27 9.1 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Neur_chan_memb PF02932.16 CDI82450.1 - 0.47 10.5 3.3 0.55 10.3 3.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OATP PF03137.20 CDI82450.1 - 0.55 8.5 1.4 0.7 8.1 1.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 CDI82450.1 - 0.59 9.9 5.6 0.83 9.4 5.6 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4834 PF16118.5 CDI82450.1 - 0.84 10.6 7.4 1.4 9.9 7.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI82450.1 - 1.6 8.3 27.7 2.1 7.9 27.7 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI82450.1 - 1.9 6.9 11.2 2.3 6.6 11.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Totivirus_coat PF05518.11 CDI82450.1 - 2.8 5.9 6.9 3.2 5.7 6.9 1.0 1 0 0 1 1 1 0 Totivirus coat protein DUF2547 PF10818.8 CDI82450.1 - 3 8.8 18.7 5.3 8.0 18.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2547) EIIBC-GUT_N PF03612.14 CDI82450.1 - 4.3 7.1 7.7 6.2 6.5 7.7 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TERB2 PF15101.6 CDI82450.1 - 4.6 7.2 13.0 6.2 6.8 13.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RRM_1 PF00076.22 CDI82451.1 - 1.8e-41 139.8 0.1 1.1e-15 57.2 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI82451.1 - 1.1e-09 38.3 0.1 0.015 15.4 0.0 4.1 3 0 0 3 3 3 3 RNA recognition motif WW PF00397.26 CDI82451.1 - 3.7e-06 26.9 3.6 7.7e-06 25.9 3.6 1.5 1 0 0 1 1 1 1 WW domain RNA_bind PF08675.11 CDI82451.1 - 0.049 13.7 0.0 2.2 8.4 0.0 3.3 3 0 0 3 3 3 0 RNA binding domain YgbB PF02542.16 CDI82452.1 - 1.2e-47 162.0 0.7 5.8e-42 143.6 0.5 2.2 2 0 0 2 2 2 2 YgbB family RNA_pol PF00940.19 CDI82453.1 - 1e-135 452.8 0.0 1e-135 452.8 0.0 2.3 2 0 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CDI82453.1 - 1.3e-12 47.7 8.6 3.5e-09 36.5 0.2 8.2 6 2 1 7 7 7 3 DNA-directed RNA polymerase N-terminal PilM PF07419.12 CDI82455.1 - 7.5 6.7 6.2 1.2 9.3 1.3 2.3 2 0 0 2 2 2 0 PilM Cluap1 PF10234.9 CDI82456.1 - 1.7e-08 34.2 10.7 3.2e-08 33.3 10.7 1.4 1 0 0 1 1 1 1 Clusterin-associated protein-1 Motilin_assoc PF04643.12 CDI82456.1 - 0.058 13.3 0.6 0.99 9.3 0.1 2.8 2 0 0 2 2 2 0 Motilin/ghrelin-associated peptide TMCO5 PF14992.6 CDI82456.1 - 0.35 10.4 4.0 0.5 9.9 4.0 1.4 1 0 0 1 1 1 0 TMCO5 family FlaC_arch PF05377.11 CDI82456.1 - 0.55 10.7 1.8 0.6 10.5 0.1 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) AAA_13 PF13166.6 CDI82456.1 - 1.5 7.4 8.0 0.7 8.5 5.5 1.7 1 1 0 1 1 1 0 AAA domain UPF0242 PF06785.11 CDI82456.1 - 3 7.9 8.5 1.9 8.5 6.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DEAD PF00270.29 CDI82457.1 - 5.7e-36 123.9 0.0 9e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI82457.1 - 8.1e-24 84.1 0.0 1.8e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI82457.1 - 8.6e-05 22.6 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1724 PF08350.10 CDI82459.1 - 0.031 14.4 0.0 5 7.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1724) DUF2175 PF09943.9 CDI82459.1 - 0.065 13.5 1.0 0.077 13.3 0.1 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) DUF2116 PF09889.9 CDI82459.1 - 0.13 12.3 1.9 0.77 9.8 0.5 2.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Cpn60_TCP1 PF00118.24 CDI82461.1 - 3.9e-32 111.5 0.1 4.5e-32 111.3 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3798 PF12683.7 CDI82461.1 - 0.057 12.8 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) PilI PF10623.9 CDI82462.1 - 0.12 12.5 0.5 1.4 9.1 0.5 2.0 1 1 0 1 1 1 0 Plasmid conjugative transfer protein PilI ketoacyl-synt PF00109.26 CDI82466.1 - 5e-126 419.4 0.1 2e-62 211.0 0.1 2.3 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDI82466.1 - 2.8e-57 191.8 0.6 3e-35 120.8 0.1 2.6 2 0 0 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDI82466.1 - 1.8e-12 47.4 0.5 3.4e-11 43.3 0.0 2.7 2 0 0 2 2 2 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDI82466.1 - 3.1e-06 27.6 0.0 8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CDI82466.1 - 2.6e-05 23.7 7.4 0.0085 15.5 0.4 3.6 4 0 0 4 4 4 2 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CDI82466.1 - 0.037 13.9 5.9 0.046 13.6 0.7 3.3 3 1 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EF-hand_7 PF13499.6 CDI82467.1 - 1.5e-10 41.4 0.3 2.7e-10 40.5 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CDI82467.1 - 2.9e-10 39.8 0.4 5.7e-10 38.9 0.4 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CDI82467.1 - 4e-10 38.5 0.7 6.7e-05 22.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDI82467.1 - 6.2e-08 32.0 3.6 0.0037 17.1 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain DUF1126 PF06565.12 CDI82467.1 - 8.1e-07 28.8 0.0 0.0013 18.5 0.0 2.8 2 1 1 3 3 3 2 DUF1126 PH-like domain EF-hand_5 PF13202.6 CDI82467.1 - 0.0018 17.7 0.0 0.0074 15.7 0.0 2.0 2 0 0 2 2 2 1 EF hand HEAT PF02985.22 CDI82468.1 - 0.048 13.9 10.6 0.88 10.0 0.2 6.1 5 0 0 5 5 5 0 HEAT repeat PIN_6 PF17146.4 CDI82469.1 - 1.6e-18 67.0 0.0 4.6e-18 65.5 0.0 1.8 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 CDI82469.1 - 1.7e-18 66.5 0.2 2.8e-18 65.9 0.2 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.11 CDI82469.1 - 0.017 14.8 0.6 3.8 7.2 0.0 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain OrfB_Zn_ribbon PF07282.11 CDI82469.1 - 0.097 12.6 0.9 0.2 11.6 0.9 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Nudix_N_2 PF14803.6 CDI82469.1 - 0.17 11.8 1.6 6.6 6.7 0.1 2.5 2 0 0 2 2 2 0 Nudix N-terminal Dus PF01207.17 CDI82470.1 - 7.4e-39 133.7 0.0 1.6e-32 112.8 0.0 2.4 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) FleQ PF06490.11 CDI82470.1 - 0.034 14.5 0.1 0.21 12.0 0.0 2.4 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ zf-CCCH PF00642.24 CDI82470.1 - 1.5 8.8 10.0 8.1 6.5 10.0 2.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ApoLp-III PF07464.11 CDI82471.1 - 0.033 14.3 0.3 0.033 14.3 0.3 2.5 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) 3-alpha PF03475.14 CDI82471.1 - 0.062 13.2 1.5 11 6.0 0.1 2.9 2 0 0 2 2 2 0 3-alpha domain CorA PF01544.18 CDI82471.1 - 0.38 10.0 4.0 1.7 7.9 0.9 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein HA2 PF04408.23 CDI82474.1 - 5.9e-10 39.4 1.1 2.6e-09 37.3 0.1 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI82474.1 - 0.00049 20.4 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Ribosomal_60s PF00428.19 CDI82474.1 - 0.14 12.8 4.3 0.32 11.6 4.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Spt20 PF12090.8 CDI82477.1 - 0.0049 16.5 6.7 0.0082 15.8 6.7 1.3 1 0 0 1 1 1 1 Spt20 family Macoilin PF09726.9 CDI82477.1 - 0.02 13.5 4.7 0.021 13.4 4.7 1.1 1 0 0 1 1 1 0 Macoilin family Herpes_capsid PF06112.11 CDI82477.1 - 0.043 13.9 5.6 0.081 13.0 5.6 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein PH PF00169.29 CDI82477.1 - 0.07 13.6 0.1 0.13 12.8 0.1 1.7 1 1 0 1 1 1 0 PH domain DUF1635 PF07795.11 CDI82477.1 - 0.076 12.9 4.7 0.14 12.0 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) RAP1 PF07218.11 CDI82477.1 - 0.3 9.3 7.0 0.33 9.2 7.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Secretin_N_2 PF07655.13 CDI82477.1 - 1.4 9.5 18.1 0.042 14.4 12.2 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain Miga PF10265.9 CDI82477.1 - 2.5 7.0 10.6 1.9 7.4 9.4 1.4 1 1 1 2 2 2 0 Mitoguardin Pkinase PF00069.25 CDI82478.1 - 1e-05 25.1 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI82478.1 - 1e-05 25.0 0.0 3.5e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI82478.1 - 0.00023 20.5 0.0 0.00042 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ANAPC10 PF03256.16 CDI82481.1 - 8.3e-10 38.6 0.0 1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Sortilin-Vps10 PF15902.5 CDI82483.1 - 3.8e-60 203.9 0.1 1.4e-40 139.4 0.1 2.0 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 CDI82483.1 - 0.00063 19.4 2.7 0.93 9.8 0.1 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat Ribosomal_60s PF00428.19 CDI82483.1 - 0.023 15.3 7.9 0.037 14.6 7.9 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein BNR_2 PF13088.6 CDI82483.1 - 0.17 11.1 0.0 10 5.3 0.0 2.6 2 1 0 2 2 2 0 BNR repeat-like domain Casc1_N PF15927.5 CDI82483.1 - 2.8 7.6 11.7 3.9 7.1 10.0 1.8 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus RAP1 PF07218.11 CDI82493.1 - 0.11 10.8 8.2 0.1 10.8 8.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AF-4 PF05110.13 CDI82493.1 - 0.19 9.8 39.9 0.26 9.3 39.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SprA-related PF12118.8 CDI82493.1 - 0.7 9.0 34.8 0.9 8.6 34.8 1.2 1 0 0 1 1 1 0 SprA-related family Peptidase_S64 PF08192.11 CDI82493.1 - 1.1 7.6 25.6 1.6 7.1 25.6 1.2 1 0 0 1 1 1 0 Peptidase family S64 Presenilin PF01080.17 CDI82493.1 - 1.5 7.5 25.1 2.2 7.0 25.1 1.2 1 0 0 1 1 1 0 Presenilin DUF572 PF04502.13 CDI82493.1 - 1.6 8.3 19.8 2 8.0 19.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) AAA_23 PF13476.6 CDI82493.1 - 4 7.9 22.3 5.3 7.5 22.3 1.1 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 CDI82493.1 - 5.8 6.8 45.5 8.2 6.3 45.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SSP160 PF06933.11 CDI82493.1 - 8.4 4.4 22.7 14 3.7 22.7 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RNA_pol_Rpb2_1 PF04563.15 CDI82495.1 - 1.6e-27 96.4 0.0 7.2e-27 94.2 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase beta subunit Blt1_C PF17183.4 CDI82495.1 - 0.076 12.6 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Get5 carboxyl domain IMUP PF15761.5 CDI82497.1 - 0.0022 18.7 13.5 0.0035 18.0 13.5 1.4 1 0 0 1 1 1 1 Immortalisation up-regulated protein Pex26 PF07163.12 CDI82497.1 - 0.091 12.1 3.3 0.1 11.9 3.3 1.1 1 0 0 1 1 1 0 Pex26 protein DUF1616 PF07760.11 CDI82497.1 - 0.12 11.8 1.9 0.13 11.6 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) SR-25 PF10500.9 CDI82497.1 - 0.12 11.9 19.6 0.17 11.5 19.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Rubella_Capsid PF05750.11 CDI82497.1 - 0.19 11.3 6.4 0.26 10.9 6.4 1.2 1 0 0 1 1 1 0 Rubella capsid protein DUF755 PF05501.11 CDI82497.1 - 0.2 12.0 19.3 0.25 11.6 19.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Pox_A12 PF04651.13 CDI82497.1 - 0.38 10.8 3.9 0.47 10.5 3.9 1.1 1 0 0 1 1 1 0 Poxvirus A12 protein Coilin_N PF15862.5 CDI82497.1 - 0.96 9.3 8.3 1.2 8.9 8.3 1.1 1 0 0 1 1 1 0 Coilin N-terminus baeRF_family12 PF18856.1 CDI82497.1 - 2.5 8.7 6.0 3.3 8.3 6.0 1.1 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 DUF572 PF04502.13 CDI82499.1 - 0.0076 15.9 11.2 0.0094 15.6 11.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) ATP-synt_D PF01813.17 CDI82505.1 - 1.4e-40 139.2 0.3 2.1e-40 138.7 0.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit D SpoIIP PF07454.11 CDI82507.1 - 0.006 16.1 11.3 0.006 16.1 11.3 1.0 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CDI82507.1 - 0.0071 15.4 7.5 0.0075 15.3 7.5 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Trypan_glycop_C PF10659.9 CDI82507.1 - 0.011 16.1 7.9 0.011 16.1 7.9 1.1 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain V_ATPase_I PF01496.19 CDI82507.1 - 0.021 12.8 10.8 0.017 13.0 10.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PPL5 PF18168.1 CDI82507.1 - 0.032 13.5 6.4 0.034 13.5 6.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 FYDLN_acid PF09538.10 CDI82507.1 - 0.044 14.5 6.6 0.046 14.4 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) GEN1_C PF18380.1 CDI82507.1 - 0.048 14.6 5.5 0.057 14.3 5.5 1.1 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain EPL1 PF10513.9 CDI82507.1 - 0.051 13.9 12.3 0.051 14.0 12.3 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Connexin PF00029.19 CDI82507.1 - 0.066 13.0 9.5 0.067 12.9 9.5 1.0 1 0 0 1 1 1 0 Connexin PIP5K PF01504.18 CDI82507.1 - 0.067 12.4 10.8 0.069 12.4 10.8 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DDRGK PF09756.9 CDI82507.1 - 0.068 12.8 18.2 0.073 12.7 18.2 1.1 1 0 0 1 1 1 0 DDRGK domain Gti1_Pac2 PF09729.9 CDI82507.1 - 0.072 13.2 7.4 0.069 13.2 7.4 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family PBP1_TM PF14812.6 CDI82507.1 - 0.087 13.2 4.3 0.1 13.0 4.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2370 PF10176.9 CDI82507.1 - 0.091 12.4 3.6 0.088 12.4 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DDHD PF02862.17 CDI82507.1 - 0.091 12.9 9.7 0.083 13.0 9.7 1.1 1 0 0 1 1 1 0 DDHD domain Pex14_N PF04695.13 CDI82507.1 - 0.096 13.3 20.7 0.1 13.2 20.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI82507.1 - 0.11 11.3 14.5 0.1 11.4 14.5 1.1 1 0 0 1 1 1 0 Presenilin DUF2368 PF10166.9 CDI82507.1 - 0.12 12.0 17.5 0.13 11.9 17.5 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Eapp_C PF10238.9 CDI82507.1 - 0.14 12.3 12.9 0.14 12.2 12.9 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein FAM176 PF14851.6 CDI82507.1 - 0.16 11.7 6.9 0.18 11.5 6.9 1.2 1 0 0 1 1 1 0 FAM176 family HCO3_cotransp PF00955.21 CDI82507.1 - 0.16 10.7 3.2 0.17 10.7 3.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF1764 PF08576.10 CDI82507.1 - 0.18 12.7 10.2 0.19 12.6 10.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF5523 PF17661.1 CDI82507.1 - 0.24 11.1 15.1 0.26 10.9 15.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) MMU163 PF17119.5 CDI82507.1 - 0.25 10.5 4.1 0.24 10.5 4.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Afi1 PF07792.12 CDI82507.1 - 0.26 11.8 12.9 0.28 11.7 12.9 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Slu7 PF11708.8 CDI82507.1 - 0.31 10.8 14.5 0.31 10.8 14.5 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Suf PF05843.14 CDI82507.1 - 0.31 11.0 16.7 0.31 11.0 16.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) NPR3 PF03666.13 CDI82507.1 - 0.32 9.8 11.4 0.3 9.8 11.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RED_N PF07808.13 CDI82507.1 - 0.37 10.3 13.3 0.38 10.3 13.3 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region MDM10 PF12519.8 CDI82507.1 - 0.43 9.4 9.4 0.4 9.5 9.4 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TFIIA PF03153.13 CDI82507.1 - 0.49 10.3 37.0 0.47 10.4 37.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI82507.1 - 0.51 10.3 8.4 0.51 10.3 8.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CCDC53 PF10152.9 CDI82507.1 - 0.64 10.4 14.5 0.7 10.3 14.5 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Peptidase_S64 PF08192.11 CDI82507.1 - 0.64 8.4 10.0 0.61 8.5 10.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF3405 PF11885.8 CDI82507.1 - 0.72 8.4 11.6 0.77 8.3 11.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF5352 PF17303.2 CDI82507.1 - 0.73 9.7 8.2 0.8 9.5 8.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5352) RPA43_OB PF17875.1 CDI82507.1 - 0.75 10.4 9.2 0.83 10.3 9.2 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DUF5308 PF17233.2 CDI82507.1 - 0.85 9.8 11.0 0.83 9.9 11.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) RR_TM4-6 PF06459.12 CDI82507.1 - 0.88 9.3 14.9 1 9.1 14.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rxt3 PF08642.10 CDI82507.1 - 0.89 10.3 6.6 0.99 10.2 6.6 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 SID-1_RNA_chan PF13965.6 CDI82507.1 - 0.9 7.9 6.1 0.82 8.0 6.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MPM1 PF17234.2 CDI82507.1 - 0.9 9.8 16.2 0.96 9.7 16.2 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF775 PF05603.12 CDI82507.1 - 0.95 9.0 14.4 1.2 8.6 14.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF3408 PF11888.8 CDI82507.1 - 0.96 9.6 14.6 1.1 9.4 14.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) BRF1 PF07741.13 CDI82507.1 - 0.99 9.8 10.8 1.1 9.6 10.8 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Tim54 PF11711.8 CDI82507.1 - 1.1 8.0 13.4 1.2 7.9 13.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sec62 PF03839.16 CDI82507.1 - 1.1 8.7 9.9 1.1 8.7 9.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SLC12 PF03522.15 CDI82507.1 - 1.1 8.2 13.4 1.1 8.2 13.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 EIIBC-GUT_N PF03612.14 CDI82507.1 - 1.2 8.9 12.8 1.2 8.9 12.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PepSY_TM PF03929.16 CDI82507.1 - 1.2 8.8 6.9 1.1 8.8 6.9 1.1 1 0 0 1 1 1 0 PepSY-associated TM region CLN3 PF02487.17 CDI82507.1 - 1.2 8.1 10.1 1.2 8.2 10.1 1.0 1 0 0 1 1 1 0 CLN3 protein Band_3_cyto PF07565.13 CDI82507.1 - 1.2 8.9 12.8 1.3 8.8 12.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Orf78 PF06024.12 CDI82507.1 - 1.3 9.4 8.6 1.9 8.8 8.6 1.4 1 0 0 1 1 1 0 Orf78 (ac78) CDC45 PF02724.14 CDI82507.1 - 1.5 7.1 11.3 1.4 7.1 11.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Renin_r PF07850.14 CDI82507.1 - 1.6 9.3 4.4 2.2 8.9 4.4 1.4 1 0 0 1 1 1 0 Renin receptor-like protein DUF4192 PF13830.6 CDI82507.1 - 1.7 8.6 5.5 1.7 8.6 5.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Peroxin-13_N PF04088.13 CDI82507.1 - 1.7 8.9 8.0 2 8.7 8.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Kei1 PF08552.11 CDI82507.1 - 1.8 8.4 8.2 1.9 8.3 8.2 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF853 PF05872.12 CDI82507.1 - 2.1 6.9 9.2 2 6.9 9.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Ndc1_Nup PF09531.10 CDI82507.1 - 2.1 6.9 10.1 2.1 6.9 10.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup eIF-3_zeta PF05091.12 CDI82507.1 - 2.1 7.2 21.4 2.1 7.2 21.4 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4518 PF15008.6 CDI82507.1 - 2.1 7.4 15.1 2.1 7.5 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) CPSF100_C PF13299.6 CDI82507.1 - 2.2 8.4 13.1 2.5 8.3 13.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S49_N PF08496.10 CDI82507.1 - 2.7 8.0 14.3 3 7.9 14.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4175 PF13779.6 CDI82507.1 - 2.8 5.7 35.8 2.7 5.8 35.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EOS1 PF12326.8 CDI82507.1 - 3.6 7.5 8.5 4.1 7.3 8.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 CDI82507.1 - 3.8 7.5 10.7 3.7 7.5 10.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2946 PF11162.8 CDI82507.1 - 3.8 8.2 8.3 4 8.1 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) Zip PF02535.22 CDI82507.1 - 3.9 6.6 8.4 4.1 6.5 8.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter F-protein PF00469.20 CDI82507.1 - 4 7.0 14.7 4.5 6.8 14.7 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef ORC_WH_C PF18137.1 CDI82507.1 - 4.7 7.3 16.9 5.4 7.1 16.9 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Membralin PF09746.9 CDI82507.1 - 4.7 6.1 8.8 4.3 6.3 8.8 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF3371 PF11851.8 CDI82507.1 - 4.8 8.3 17.8 5.5 8.1 17.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) OATP PF03137.20 CDI82507.1 - 4.9 5.3 9.8 4.8 5.4 9.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF702 PF05142.12 CDI82507.1 - 4.9 7.6 15.3 5.5 7.5 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) MDM31_MDM32 PF08118.11 CDI82507.1 - 5.1 5.7 12.3 5.3 5.6 12.3 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Serinc PF03348.15 CDI82507.1 - 5.5 5.8 12.0 6 5.7 12.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DcuA_DcuB PF03605.14 CDI82507.1 - 5.6 5.7 5.5 5.6 5.8 5.5 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter ALMT PF11744.8 CDI82507.1 - 6.1 5.6 10.9 5.9 5.6 10.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1075 PF06388.11 CDI82507.1 - 6.3 6.9 7.8 6.8 6.8 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) PIG-S PF10510.9 CDI82507.1 - 6.4 5.5 13.5 5.8 5.6 13.5 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Ureide_permease PF07168.11 CDI82507.1 - 6.7 5.4 7.6 6.7 5.4 7.6 1.1 1 0 0 1 1 1 0 Ureide permease FAM91_C PF14648.6 CDI82507.1 - 7.8 5.2 10.4 7.5 5.3 10.4 1.0 1 0 0 1 1 1 0 FAM91 C-terminus PRP1_N PF06424.12 CDI82507.1 - 8 6.8 17.1 10 6.5 17.1 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal CSG2 PF16965.5 CDI82507.1 - 8.8 5.2 9.9 9.5 5.0 9.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Glt_symporter PF03616.14 CDI82507.1 - 9.1 4.8 5.4 9.3 4.8 5.4 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF4638 PF15472.6 CDI82507.1 - 9.4 5.9 12.6 9.2 5.9 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) ABC2_membrane_2 PF12679.7 CDI82507.1 - 9.6 5.4 7.8 9.6 5.4 7.8 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Mpp10 PF04006.12 CDI82511.1 - 0.62 8.4 11.8 0.83 8.0 11.8 1.2 1 0 0 1 1 1 0 Mpp10 protein SPX PF03105.19 CDI82511.1 - 0.7 9.8 36.7 0.96 9.3 36.7 1.2 1 0 0 1 1 1 0 SPX domain SLC12 PF03522.15 CDI82511.1 - 1.2 8.1 11.1 1.5 7.8 11.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Utp14 PF04615.13 CDI82511.1 - 2.2 6.7 19.4 2.6 6.5 19.4 1.0 1 0 0 1 1 1 0 Utp14 protein zf-RING_2 PF13639.6 CDI82514.1 - 0.66 10.4 2.4 1.1 9.6 2.4 1.4 1 0 0 1 1 1 0 Ring finger domain BAF1_ABF1 PF04684.13 CDI82522.1 - 8.2 5.3 22.6 13 4.7 22.6 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF1645 PF07816.11 CDI82523.1 - 0.0046 17.6 25.5 0.006 17.2 25.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1645) AAA_11 PF13086.6 CDI82523.1 - 0.038 13.8 16.6 0.043 13.6 16.6 1.1 1 0 0 1 1 1 0 AAA domain BRF1 PF07741.13 CDI82523.1 - 0.18 12.1 11.0 0.24 11.8 11.0 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain PepSY_TM PF03929.16 CDI82523.1 - 0.37 10.4 8.1 0.39 10.3 8.1 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DDRGK PF09756.9 CDI82523.1 - 0.39 10.3 17.5 0.41 10.2 17.5 1.1 1 0 0 1 1 1 0 DDRGK domain Serinc PF03348.15 CDI82523.1 - 0.61 9.0 11.2 0.67 8.8 11.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) PI3K_1B_p101 PF10486.9 CDI82523.1 - 0.73 7.5 22.0 0.89 7.3 22.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TFIIA PF03153.13 CDI82523.1 - 1.2 9.0 46.6 1.4 8.8 46.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI82523.1 - 1.6 7.2 31.5 1.6 7.2 31.5 1.0 1 0 0 1 1 1 0 Macoilin family eIF-3_zeta PF05091.12 CDI82523.1 - 2.1 7.3 24.0 2.3 7.1 24.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) USP8_interact PF08941.10 CDI82523.1 - 2.3 8.0 15.8 2.6 7.8 15.8 1.1 1 0 0 1 1 1 0 USP8 interacting FemAB PF02388.16 CDI82523.1 - 2.3 7.0 14.1 2.5 6.9 14.1 1.0 1 0 0 1 1 1 0 FemAB family Peptidase_U57 PF05582.12 CDI82523.1 - 2.4 7.4 10.4 2.6 7.2 10.4 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Peptidase_S64 PF08192.11 CDI82523.1 - 2.6 6.4 36.4 3.2 6.1 36.4 1.0 1 0 0 1 1 1 0 Peptidase family S64 Endonuc_Holl PF10107.9 CDI82523.1 - 3 7.7 13.4 3.7 7.4 13.4 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase MecA PF05389.12 CDI82523.1 - 3.1 7.4 14.9 3.7 7.1 14.9 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF3807 PF12720.7 CDI82523.1 - 3.2 8.0 28.9 3.8 7.7 28.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Plasmodium_Vir PF05795.11 CDI82523.1 - 4 6.8 21.4 4.5 6.6 21.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.12 CDI82523.1 - 4 7.2 20.7 4.4 7.0 20.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Miga PF10265.9 CDI82523.1 - 4.2 6.2 28.7 4.8 6.0 28.7 1.0 1 0 0 1 1 1 0 Mitoguardin Glu_synthase PF01645.17 CDI82523.1 - 4.3 6.4 10.0 4.9 6.2 10.0 1.0 1 0 0 1 1 1 0 Conserved region in glutamate synthase Tim54 PF11711.8 CDI82523.1 - 5.8 5.6 19.9 6.1 5.5 19.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 LTV PF04180.14 CDI82523.1 - 5.9 6.5 22.5 7 6.3 22.5 1.1 1 0 0 1 1 1 0 Low temperature viability protein XRN_N PF03159.18 CDI82523.1 - 6.2 6.2 13.9 7.3 5.9 13.9 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus NST1 PF13945.6 CDI82523.1 - 6.4 6.8 31.8 7.2 6.7 31.8 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF4770 PF15994.5 CDI82523.1 - 6.6 6.9 21.1 8.2 6.6 21.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Lin-8 PF03353.15 CDI82523.1 - 7.1 6.1 34.3 9.3 5.7 34.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4746 PF15928.5 CDI82523.1 - 7.6 5.9 11.8 8 5.8 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Sec62 PF03839.16 CDI82523.1 - 7.7 6.0 13.5 8.4 5.8 13.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4407 PF14362.6 CDI82523.1 - 8.3 5.7 18.1 8.7 5.6 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) API5 PF05918.11 CDI82523.1 - 9.7 4.9 21.4 11 4.7 21.4 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Dynein_C PF18199.1 CDI82524.1 - 1.1e-06 28.2 0.1 0.0016 17.7 0.0 2.3 2 1 0 2 2 2 2 Dynein heavy chain C-terminal domain E1_dh PF00676.20 CDI82531.1 - 3.4e-34 118.2 0.0 3.4e-34 118.2 0.0 1.7 2 0 0 2 2 2 1 Dehydrogenase E1 component Transket_pyr PF02779.24 CDI82531.1 - 7.9e-31 107.1 0.0 1.4e-30 106.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain 2-oxogl_dehyd_N PF16078.5 CDI82531.1 - 9.2e-17 60.4 0.3 8.1e-15 54.1 0.1 2.5 2 0 0 2 2 2 2 2-oxoglutarate dehydrogenase N-terminus TFIIA PF03153.13 CDI82532.1 - 0.00045 20.3 11.4 0.00045 20.3 11.4 11.5 2 2 7 10 10 10 1 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 CDI82533.1 - 0.079 12.1 7.7 0.14 11.4 7.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Guanylate_cyc PF00211.20 CDI82534.1 - 1.3e-51 174.9 0.0 5.2e-31 107.7 0.0 4.0 2 2 1 3 3 3 3 Adenylate and Guanylate cyclase catalytic domain Hydrolase PF00702.26 CDI82534.1 - 0.032 14.5 0.0 0.48 10.7 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDI82534.1 - 0.071 12.6 0.1 0.36 10.3 0.0 2.2 2 1 0 2 2 2 0 E1-E2 ATPase CCSAP PF15748.5 CDI82535.1 - 0.1 12.8 50.5 0.99 9.5 25.9 2.1 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Caldesmon PF02029.15 CDI82535.1 - 0.12 11.2 51.7 0.17 10.6 51.7 1.2 1 0 0 1 1 1 0 Caldesmon SLC12 PF03522.15 CDI82535.1 - 0.18 10.8 48.8 0.012 14.6 12.6 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Tim54 PF11711.8 CDI82535.1 - 0.33 9.7 32.3 1.1 8.0 7.8 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MDM10 PF12519.8 CDI82535.1 - 1.2 8.0 37.3 1.1 8.0 16.5 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Hid1 PF12722.7 CDI82535.1 - 3.2 5.8 41.5 0.15 10.1 10.0 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Membralin PF09746.9 CDI82535.1 - 4.5 6.2 33.3 0.38 9.7 8.6 2.1 2 0 0 2 2 2 0 Tumour-associated protein FAM60A PF15396.6 CDI82535.1 - 4.7 7.2 43.2 0.76 9.7 13.6 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Lin-8 PF03353.15 CDI82535.1 - 4.8 6.7 55.8 2.2 7.8 20.5 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF3807 PF12720.7 CDI82535.1 - 8.9 6.5 62.7 5.4 7.2 23.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Integrase_H2C2 PF17921.1 CDI82537.1 - 2.2e-14 53.3 0.2 3.7e-14 52.6 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDI82537.1 - 0.0026 17.9 0.3 0.0047 17.1 0.3 1.4 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 CDI82537.1 - 0.0035 17.5 0.0 0.0097 16.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 CDI82540.1 - 6.8e-12 45.6 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CDI82540.1 - 5.8e-06 26.1 0.4 1.3e-05 25.0 0.4 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SecM PF06558.12 CDI82540.1 - 0.077 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) Pkinase PF00069.25 CDI82543.1 - 4.6e-16 59.0 0.0 4.6e-15 55.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82543.1 - 0.022 14.0 0.0 0.087 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase Spt20 PF12090.8 CDI82543.1 - 6.5 6.3 8.2 9.9 5.7 8.2 1.3 1 0 0 1 1 1 0 Spt20 family Lysine_decarbox PF03641.14 CDI82548.1 - 3.9e-24 85.2 0.0 7.8e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CDI82548.1 - 2.2e-09 37.1 0.0 3.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 SLOG cluster4 family DUF4913 PF16259.5 CDI82548.1 - 0.11 12.6 1.2 0.23 11.5 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) TPX2 PF06886.11 CDI82548.1 - 0.59 10.4 4.8 1.3 9.4 4.8 1.5 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Trm112p PF03966.16 CDI82549.1 - 5.5e-15 55.7 0.1 7.9e-15 55.2 0.1 1.2 1 0 0 1 1 1 1 Trm112p-like protein zf-UDP PF14569.6 CDI82549.1 - 0.035 14.2 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger SRAP PF02586.14 CDI82550.1 - 1.7e-35 122.5 3.4 8.4e-31 107.2 0.0 2.6 2 1 0 2 2 2 2 SOS response associated peptidase (SRAP) DUF2464 PF10240.9 CDI82550.1 - 5 6.6 9.6 13 5.3 9.6 1.7 1 0 0 1 1 1 0 Multivesicular body subunit 12 Zip PF02535.22 CDI82550.1 - 5.8 6.0 9.6 12 5.0 9.6 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 CDI82550.1 - 7.6 4.8 5.1 11 4.2 5.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TPPII_N PF12583.8 CDI82552.1 - 0.87 10.2 6.6 1.1 9.9 6.6 1.2 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal UCH PF00443.29 CDI82553.1 - 1.3e-18 67.4 0.0 5.6e-18 65.4 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Sporozoite_P67 PF05642.11 CDI82554.1 - 0.0011 17.1 2.3 0.0011 17.1 2.3 4.5 4 2 0 4 4 4 1 Sporozoite P67 surface antigen SpoIIP PF07454.11 CDI82554.1 - 0.046 13.2 6.1 0.8 9.1 1.1 2.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF4471 PF14740.6 CDI82554.1 - 5.4 6.1 10.1 1.5 8.0 1.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) Kinase-like PF14531.6 CDI82558.1 - 1.2e-07 31.4 0.0 1.2e-06 28.1 0.0 2.0 1 1 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI82558.1 - 1.1e-06 28.2 0.0 1.7e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82558.1 - 0.0012 18.2 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PAN_1 PF00024.26 CDI82560.1 - 7.4e-22 77.1 11.6 4.1e-07 29.9 1.6 3.2 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.6 CDI82560.1 - 2.7e-21 75.2 17.6 4.6e-07 29.6 1.7 3.6 3 0 0 3 3 3 3 PAN domain PAN_2 PF08276.11 CDI82560.1 - 0.015 15.4 13.8 0.28 11.3 0.4 3.3 3 0 0 3 3 3 0 PAN-like domain MANEC PF07502.14 CDI82560.1 - 0.079 13.2 8.8 8.7 6.7 0.2 3.4 3 0 0 3 3 3 0 MANEC domain PAN_3 PF08277.12 CDI82560.1 - 0.6 10.0 12.3 0.56 10.1 1.3 3.3 3 0 0 3 3 3 0 PAN-like domain LRR_4 PF12799.7 CDI82561.1 - 2e-19 69.4 16.5 2.5e-08 34.1 1.9 4.0 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDI82561.1 - 2e-14 53.5 3.7 6.8e-09 35.5 1.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 CDI82561.1 - 4.7e-08 32.7 10.3 0.00064 19.4 1.3 3.6 1 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 CDI82561.1 - 5.5e-05 23.2 9.6 0.82 10.5 1.2 5.7 4 2 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 CDI82561.1 - 8.8e-05 22.3 11.1 0.7 10.1 0.0 5.0 4 1 1 5 5 5 3 Leucine Rich repeat DUF2811 PF10929.8 CDI82561.1 - 0.033 14.4 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) Pkinase PF00069.25 CDI82566.1 - 2.7e-46 158.1 0.0 1.3e-34 119.8 0.0 6.6 8 1 1 9 9 9 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82566.1 - 5.5e-31 107.8 0.0 5.5e-31 107.8 0.0 5.4 5 1 0 5 5 5 1 Protein tyrosine kinase Spore_III_AF PF09581.10 CDI82566.1 - 1 9.4 0.0 1 9.4 0.0 11.5 10 3 2 13 13 13 0 Stage III sporulation protein AF (Spore_III_AF) HA2 PF04408.23 CDI82567.1 - 5.3e-26 91.0 0.0 1.5e-25 89.5 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI82567.1 - 5.2e-23 81.2 0.0 1.2e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 CDI82567.1 - 5.3e-08 33.1 0.0 1.4e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 CDI82567.1 - 7.7e-06 25.8 0.1 1.7e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI82567.1 - 1.2e-05 25.6 0.0 3.5e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDI82567.1 - 2.7e-05 24.4 0.0 8.5e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDI82567.1 - 0.00012 21.9 0.0 0.0004 20.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDI82567.1 - 0.00014 22.2 0.0 0.00034 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDI82567.1 - 0.0075 15.4 0.8 0.018 14.1 0.2 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein PhoH PF02562.16 CDI82567.1 - 0.015 14.8 0.1 0.058 12.8 0.2 2.0 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 CDI82567.1 - 0.023 14.0 0.0 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Microtub_bd PF16796.5 CDI82567.1 - 0.056 13.4 0.0 0.88 9.5 0.0 2.3 2 0 0 2 2 2 0 Microtubule binding AAA_7 PF12775.7 CDI82567.1 - 0.12 11.9 0.2 0.25 10.8 0.2 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CDI82567.1 - 0.54 10.3 2.6 1.5 8.9 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDI82567.1 - 5.3 7.4 6.6 0.93 9.9 0.0 2.9 4 0 0 4 4 2 0 AAA ATPase domain Apt1 PF10351.9 CDI82567.1 - 6.5 5.5 12.6 10 4.8 12.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain SUI1 PF01253.22 CDI82568.1 - 1.8e-26 92.5 0.8 2.4e-26 92.0 0.8 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 CDI82568.1 - 0.088 13.1 0.2 0.15 12.4 0.2 1.4 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) RNase_PH PF01138.21 CDI82569.1 - 4.2e-07 30.5 0.0 6.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 SpoIIP PF07454.11 CDI82570.1 - 3.9 6.8 22.9 0.14 11.6 7.3 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF2722 PF10846.8 CDI82570.1 - 5.6 5.8 57.4 0.73 8.7 25.5 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Otopetrin PF03189.13 CDI82570.1 - 8.6 5.1 6.2 4.2 6.1 2.2 2.1 2 0 0 2 2 2 0 Otopetrin Optomotor-blind PF11078.8 CDI82572.1 - 0.11 13.1 2.2 0.25 11.9 2.2 1.6 1 0 0 1 1 1 0 Optomotor-blind protein N-terminal region Ribosomal_L37ae PF01780.19 CDI82576.1 - 1.6e-33 114.6 11.1 2e-28 98.3 11.1 2.1 1 1 0 1 1 1 1 Ribosomal L37ae protein family zf-Di19 PF05605.12 CDI82576.1 - 0.018 15.3 1.7 0.041 14.2 1.7 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.13 CDI82576.1 - 0.06 13.4 5.7 6.7 6.8 5.7 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 CDI82576.1 - 0.1 13.1 0.8 0.72 10.4 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Zn_Tnp_IS1595 PF12760.7 CDI82576.1 - 3.4 7.7 9.2 1.1e+02 2.9 9.2 2.3 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Nop14 PF04147.12 CDI82580.1 - 0.04 12.1 44.4 0.049 11.9 44.4 1.1 1 0 0 1 1 1 0 Nop14-like family Caldesmon PF02029.15 CDI82580.1 - 4.5 5.9 61.0 5.5 5.6 61.0 1.1 1 0 0 1 1 1 0 Caldesmon SOBP PF15279.6 CDI82580.1 - 4.6 7.8 38.3 7.7 7.0 38.3 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Vac7 PF12751.7 CDI82580.1 - 4.8 6.5 29.6 6.1 6.2 29.6 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 GREB1 PF15782.5 CDI82580.1 - 5.4 4.0 50.4 6.3 3.8 50.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PAT1 PF09770.9 CDI82580.1 - 6.3 4.9 75.6 11 4.2 75.6 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 KAsynt_C_assoc PF16197.5 CDI82582.1 - 0.23 11.9 0.9 0.33 11.4 0.3 1.5 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension Asp_protease_2 PF13650.6 CDI82585.1 - 0.00094 19.8 0.0 0.0024 18.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDI82585.1 - 0.023 15.3 0.0 0.055 14.0 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease AAA_6 PF12774.7 CDI82586.1 - 1.2e-118 395.8 0.1 6e-116 387.0 0.0 3.6 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 CDI82586.1 - 5.9e-87 291.3 0.1 1.6e-86 289.8 0.1 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 CDI82586.1 - 2.9e-55 186.6 0.0 3.2e-49 166.9 0.0 4.2 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_9 PF12781.7 CDI82586.1 - 5.2e-55 186.0 3.8 2.4e-51 174.0 1.8 3.2 3 1 1 4 4 3 2 ATP-binding dynein motor region AAA_lid_11 PF18198.1 CDI82586.1 - 1e-49 168.5 0.0 2.6e-49 167.2 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_C PF18199.1 CDI82586.1 - 8e-47 159.9 4.5 9.1e-46 156.5 0.1 3.5 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 CDI82586.1 - 8.4e-39 132.3 0.0 5e-38 129.8 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 CDI82586.1 - 9.4e-33 113.7 12.2 9.4e-33 113.7 12.2 1.9 3 0 0 3 3 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 CDI82586.1 - 1.6e-21 76.7 0.0 3e-07 30.5 0.0 5.5 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDI82586.1 - 5.1e-21 75.1 0.7 2e-20 73.2 0.7 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 CDI82586.1 - 1.4e-19 70.1 2.1 1.7e-18 66.7 0.1 3.4 2 0 0 2 2 2 1 AAA+ lid domain AAA PF00004.29 CDI82586.1 - 1.4e-07 32.0 0.2 0.5 10.8 0.0 5.3 4 1 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI82586.1 - 4.9e-06 27.0 8.7 4.5 7.6 0.0 6.9 6 1 1 7 7 7 1 AAA ATPase domain AAA_22 PF13401.6 CDI82586.1 - 7.2e-05 23.1 7.8 1.3 9.3 0.0 6.0 7 0 0 7 7 6 1 AAA domain AAA_18 PF13238.6 CDI82586.1 - 0.0015 19.1 0.4 4.3 7.9 0.0 4.5 4 1 0 4 4 4 1 AAA domain AAA_33 PF13671.6 CDI82586.1 - 0.012 15.8 1.2 2 8.5 0.0 3.9 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 CDI82586.1 - 0.014 14.5 0.1 0.083 11.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 CDI82586.1 - 0.028 14.2 1.1 0.43 10.4 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 CDI82586.1 - 0.03 13.7 0.2 0.44 9.9 0.0 3.0 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 CDI82586.1 - 0.038 14.1 0.0 0.23 11.6 0.0 2.4 2 0 0 2 2 1 0 50S ribosome-binding GTPase AAA_19 PF13245.6 CDI82586.1 - 0.039 14.3 4.8 13 6.1 0.0 4.1 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 CDI82586.1 - 0.062 13.0 0.0 17 5.1 0.0 3.5 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 CDI82586.1 - 0.27 10.9 1.5 45 3.7 0.1 3.3 3 0 0 3 3 3 0 AAA domain DUF4407 PF14362.6 CDI82586.1 - 0.42 9.9 21.7 1.1 8.5 6.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) MCU PF04678.13 CDI82586.1 - 1.1 9.4 14.5 0.66 10.0 0.5 3.7 3 0 0 3 3 3 0 Mitochondrial calcium uniporter Spc7 PF08317.11 CDI82586.1 - 3.8 6.3 40.0 0.17 10.7 1.0 3.4 3 0 0 3 3 3 0 Spc7 kinetochore protein ABC_tran PF00005.27 CDI82586.1 - 9.5 6.7 6.5 7.6 7.1 0.0 4.0 5 0 0 5 5 4 0 ABC transporter DHC_N1 PF08385.12 CDI82587.1 - 1.8e-136 456.1 13.7 1.8e-135 452.8 8.6 3.2 2 1 1 3 3 3 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 CDI82587.1 - 9.7e-84 281.8 21.7 3.1e-50 171.5 0.2 5.2 4 1 1 5 5 5 3 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 CDI82587.1 - 0.0031 16.5 0.1 0.0071 15.4 0.1 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region Nab2 PF11517.8 CDI82587.1 - 0.052 13.9 0.0 0.2 12.0 0.0 2.0 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Proteasome PF00227.26 CDI82589.1 - 1.6e-48 164.7 0.2 2.9e-48 163.9 0.0 1.5 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 CDI82589.1 - 6.6e-11 41.7 0.0 1.1e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature betaPIX_CC PF16523.5 CDI82589.1 - 0.43 10.4 8.6 0.86 9.5 8.6 1.5 1 0 0 1 1 1 0 betaPIX coiled coil DUF5600 PF18150.1 CDI82591.1 - 7.7e-40 135.8 0.1 1.3e-39 135.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) Lipase_GDSL_2 PF13472.6 CDI82591.1 - 0.044 14.2 0.0 0.071 13.5 0.0 1.4 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family SLATT_5 PF18160.1 CDI82591.1 - 0.063 12.6 0.1 0.099 12.0 0.1 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF3371 PF11851.8 CDI82592.1 - 0.00022 22.3 1.8 0.0003 21.9 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3371) DUF2722 PF10846.8 CDI82592.1 - 0.0014 17.7 13.8 0.0015 17.6 13.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) EPL1 PF10513.9 CDI82592.1 - 0.002 18.5 0.7 0.0021 18.5 0.7 1.1 1 0 0 1 1 1 1 Enhancer of polycomb-like RNase_H2_suC PF08615.11 CDI82592.1 - 0.0023 18.1 0.0 0.0023 18.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DDHD PF02862.17 CDI82592.1 - 0.0059 16.8 0.3 0.0059 16.8 0.3 1.1 1 0 0 1 1 1 1 DDHD domain Trp_oprn_chp PF09534.10 CDI82592.1 - 0.0082 16.0 4.4 0.011 15.5 4.4 1.1 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) FAM176 PF14851.6 CDI82592.1 - 0.0088 15.7 0.3 0.011 15.4 0.3 1.1 1 0 0 1 1 1 1 FAM176 family V_ATPase_I PF01496.19 CDI82592.1 - 0.013 13.5 1.5 0.014 13.3 1.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spt20 PF12090.8 CDI82592.1 - 0.019 14.6 23.8 0.024 14.2 23.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 CDI82592.1 - 0.029 15.3 5.2 0.041 14.8 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Connexin PF00029.19 CDI82592.1 - 0.03 14.1 0.5 0.034 13.9 0.5 1.1 1 0 0 1 1 1 0 Connexin Pannexin_like PF12534.8 CDI82592.1 - 0.031 13.4 1.3 0.037 13.1 1.3 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 WES_acyltransf PF03007.16 CDI82592.1 - 0.035 13.9 1.3 0.043 13.6 1.3 1.1 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain SpoIIP PF07454.11 CDI82592.1 - 0.038 13.4 3.7 0.043 13.3 3.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIA PF03153.13 CDI82592.1 - 0.039 14.0 18.3 0.048 13.7 18.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI82592.1 - 0.04 13.0 1.9 0.046 12.8 1.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4679 PF15728.5 CDI82592.1 - 0.045 12.8 9.2 0.054 12.5 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) NicO PF03824.16 CDI82592.1 - 0.062 12.6 0.1 0.074 12.4 0.1 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein Pex14_N PF04695.13 CDI82592.1 - 0.069 13.8 8.3 0.1 13.2 8.3 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TMEM51 PF15345.6 CDI82592.1 - 0.074 12.9 6.3 0.099 12.5 6.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Med15 PF09606.10 CDI82592.1 - 0.085 11.5 19.7 0.1 11.3 19.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CLN3 PF02487.17 CDI82592.1 - 0.11 11.5 1.2 0.12 11.4 1.2 1.1 1 0 0 1 1 1 0 CLN3 protein OATP PF03137.20 CDI82592.1 - 0.11 10.7 0.1 0.12 10.7 0.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ABC2_membrane_2 PF12679.7 CDI82592.1 - 0.13 11.5 1.2 0.17 11.2 1.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein UPF0560 PF10577.9 CDI82592.1 - 0.15 10.5 10.2 0.18 10.3 10.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 eIF-3_zeta PF05091.12 CDI82592.1 - 0.2 10.6 7.0 0.22 10.4 7.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI82592.1 - 0.24 10.1 5.9 0.29 9.9 5.9 1.1 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 CDI82592.1 - 0.24 9.8 2.4 0.26 9.7 2.4 1.1 1 0 0 1 1 1 0 FHIPEP family EIIBC-GUT_N PF03612.14 CDI82592.1 - 0.25 11.1 5.7 0.33 10.7 5.7 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Nucleoside_tran PF01733.18 CDI82592.1 - 0.37 10.1 0.7 0.45 9.9 0.7 1.1 1 0 0 1 1 1 0 Nucleoside transporter MCU PF04678.13 CDI82592.1 - 0.37 10.9 5.9 0.49 10.5 5.9 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TFB6 PF17110.5 CDI82592.1 - 0.42 10.3 3.2 1.3 8.7 3.7 1.5 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH PTPRCAP PF15713.5 CDI82592.1 - 0.45 10.8 14.8 0.66 10.3 14.8 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Suf PF05843.14 CDI82592.1 - 0.5 10.3 7.7 0.56 10.1 7.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DivIC PF04977.15 CDI82592.1 - 0.53 10.1 11.1 1 9.2 11.1 1.5 1 0 0 1 1 1 0 Septum formation initiator DUF4175 PF13779.6 CDI82592.1 - 0.55 8.1 18.1 0.65 7.8 18.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Roughex PF06020.11 CDI82592.1 - 0.55 9.3 11.0 0.69 9.0 11.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Activator_LAG-3 PF11498.8 CDI82592.1 - 0.69 8.8 27.1 0.86 8.5 27.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RR_TM4-6 PF06459.12 CDI82592.1 - 1.3 8.8 6.9 1.6 8.5 6.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BRF1 PF07741.13 CDI82592.1 - 1.4 9.3 9.0 2 8.8 9.0 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RED_N PF07808.13 CDI82592.1 - 1.4 8.5 10.0 1.8 8.1 10.0 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Paf1 PF03985.13 CDI82592.1 - 1.5 7.7 10.9 1.9 7.4 10.9 1.0 1 0 0 1 1 1 0 Paf1 Neur_chan_memb PF02932.16 CDI82592.1 - 1.6 8.7 4.1 2 8.4 4.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI82592.1 - 2 8.4 13.2 2.8 7.9 13.2 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CobT PF06213.12 CDI82592.1 - 2.2 7.6 15.4 2.9 7.2 15.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3138 PF11336.8 CDI82592.1 - 2.5 6.6 11.9 2.8 6.5 11.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) SHR3_chaperone PF08229.11 CDI82592.1 - 5.6 5.9 6.4 7.7 5.4 6.4 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 DUF4407 PF14362.6 CDI82592.1 - 6.6 6.0 12.0 8.6 5.6 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3464 PF11947.8 CDI82592.1 - 9.7 5.9 9.7 14 5.4 9.7 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 LCD1 PF09798.9 CDI82596.1 - 0.038 12.5 0.0 0.16 10.5 0.0 1.9 2 1 0 2 2 2 0 DNA damage checkpoint protein MSP1_C PF07462.11 CDI82596.1 - 0.87 8.2 3.7 1.8 7.2 3.7 1.4 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus IF-2 PF11987.8 CDI82599.1 - 3.8e-08 33.4 0.0 0.0011 19.0 0.0 2.3 2 0 0 2 2 2 2 Translation-initiation factor 2 AAA_assoc_2 PF16193.5 CDI82602.1 - 0.00019 21.7 0.9 0.00034 20.9 0.9 1.4 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 CDI82602.1 - 0.0021 17.9 1.0 0.0027 17.5 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit MRNIP PF15749.5 CDI82602.1 - 0.0048 17.6 3.6 0.0065 17.2 3.6 1.3 1 0 0 1 1 1 1 MRN-interacting protein Lactococcin PF04369.13 CDI82602.1 - 0.2 11.8 3.0 1.7 8.8 3.0 2.4 1 1 0 1 1 1 0 Lactococcin-like family Spt20 PF12090.8 CDI82602.1 - 0.94 9.0 12.1 1.1 8.8 12.1 1.2 1 0 0 1 1 1 0 Spt20 family Ribosomal_60s PF00428.19 CDI82602.1 - 1.6 9.4 9.3 1.7 9.3 7.7 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2644 PF10841.8 CDI82603.1 - 0.048 13.9 0.1 0.083 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2644) Adeno_E3_CR2 PF02439.15 CDI82603.1 - 0.12 12.2 0.4 0.18 11.6 0.4 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 CDI82603.1 - 0.2 12.6 0.0 0.29 12.0 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SET PF00856.28 CDI82605.1 - 7.1e-06 26.5 0.0 1.8e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 SET domain Ribophorin_I PF04597.14 CDI82606.1 - 1.9e-49 169.0 0.0 8e-31 107.7 0.0 2.2 2 0 0 2 2 2 2 Ribophorin I Apolipoprotein PF01442.18 CDI82606.1 - 0.0017 18.3 5.0 0.0029 17.5 5.0 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Chi-conotoxin PF16981.5 CDI82606.1 - 0.086 13.1 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily SKA2 PF16740.5 CDI82607.1 - 0.12 12.2 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 XhlA PF10779.9 CDI82608.1 - 4.4 7.6 19.0 0.17 12.1 0.5 4.6 4 0 0 4 4 4 0 Haemolysin XhlA NPV_P10 PF05531.12 CDI82608.1 - 5.2 7.6 12.5 2.4 8.7 1.0 5.0 3 3 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Nas2_N PF18265.1 CDI82609.1 - 6.1e-26 90.1 0.0 8.7e-26 89.7 0.0 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 CDI82609.1 - 8.9e-05 22.3 0.9 0.00046 20.0 0.1 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CDI82609.1 - 0.0017 18.7 0.0 0.03 14.7 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDI82609.1 - 0.062 13.6 0.1 0.21 12.0 0.1 2.1 1 1 1 2 2 2 0 PDZ domain Chromo PF00385.24 CDI82611.1 - 1.8e-12 46.9 0.0 2.6e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase PF00069.25 CDI82621.1 - 0.00032 20.1 0.0 0.00039 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82621.1 - 0.034 13.4 0.0 0.042 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase TAF4 PF05236.14 CDI82621.1 - 0.57 9.9 4.3 0.72 9.6 4.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CcmH PF03918.14 CDI82622.1 - 0.026 13.8 1.4 0.045 13.0 0.2 2.0 2 0 0 2 2 2 0 Cytochrome C biogenesis protein TMEM125 PF15109.6 CDI82622.1 - 0.51 10.7 0.0 0.51 10.7 0.0 3.5 3 1 1 4 4 4 0 TMEM125 protein family HhH-GPD PF00730.25 CDI82623.1 - 2.8e-05 24.5 0.6 8.1e-05 23.0 0.1 2.0 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein YppG PF14179.6 CDI82623.1 - 0.14 12.9 8.7 0.13 12.9 1.8 2.4 2 0 0 2 2 2 0 YppG-like protein TFIIA PF03153.13 CDI82623.1 - 0.41 10.6 27.1 0.6 10.1 8.9 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SPX PF03105.19 CDI82623.1 - 3.7 7.4 20.7 10 6.0 20.5 1.7 1 1 0 1 1 1 0 SPX domain Rad51 PF08423.11 CDI82626.1 - 7.5e-15 54.9 1.7 4.6e-07 29.4 0.3 3.7 3 1 0 3 3 3 2 Rad51 AAA_33 PF13671.6 CDI82626.1 - 0.0011 19.2 3.7 0.069 13.3 0.2 3.7 2 1 1 3 3 3 1 AAA domain NACHT PF05729.12 CDI82626.1 - 0.0023 17.9 3.9 0.0035 17.3 0.2 2.8 2 1 0 2 2 2 1 NACHT domain ATPase PF06745.13 CDI82626.1 - 0.014 14.7 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_22 PF13401.6 CDI82626.1 - 0.028 14.7 0.0 0.96 9.7 0.1 2.9 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDI82626.1 - 0.045 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RecA PF00154.21 CDI82626.1 - 0.046 13.2 0.0 0.22 11.0 0.0 2.0 2 0 0 2 2 2 0 recA bacterial DNA recombination protein DUF2075 PF09848.9 CDI82626.1 - 0.058 12.6 1.4 0.073 12.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 CDI82626.1 - 0.34 11.4 1.2 3.2 8.3 0.1 2.5 2 1 0 2 2 2 0 AAA domain SR-25 PF10500.9 CDI82626.1 - 6 6.4 8.5 2.3 7.8 1.0 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Suf PF05843.14 CDI82628.1 - 3e-22 80.0 0.0 3.6e-15 56.7 0.0 4.1 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 CDI82628.1 - 4.7e-05 23.8 10.8 0.38 11.3 0.1 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDI82628.1 - 0.00044 20.8 0.7 0.0038 17.9 0.1 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDI82628.1 - 0.0092 16.0 0.8 32 4.5 0.0 4.6 5 0 0 5 5 5 0 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 CDI82628.1 - 0.027 14.6 1.9 3.7 7.9 0.2 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat HAT PF02184.16 CDI82628.1 - 0.045 13.7 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Prolactin_RP PF15172.6 CDI82633.1 - 0.038 13.6 0.2 0.065 12.9 0.2 1.4 1 0 0 1 1 1 0 Prolactin-releasing peptide SEP PF08059.13 CDI82638.1 - 5.8e-23 81.3 0.1 9.2e-23 80.6 0.1 1.3 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 CDI82638.1 - 3.4e-05 24.0 0.1 6.1e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 UBX domain Fe_hyd_lg_C PF02906.14 CDI82639.1 - 3.3e-32 112.1 0.0 2.6e-13 50.2 0.0 5.3 3 1 0 3 3 3 3 Iron only hydrogenase large subunit, C-terminal domain RNA_pol_Rpc34 PF05158.12 CDI82639.1 - 0.015 14.7 0.0 0.015 14.7 0.0 3.3 4 0 0 4 4 4 0 RNA polymerase Rpc34 subunit PAP1 PF08601.10 CDI82639.1 - 0.034 13.9 0.0 0.034 13.9 0.0 4.7 5 1 1 6 6 6 0 Transcription factor PAP1 Spt20 PF12090.8 CDI82639.1 - 1.2 8.7 46.6 0.09 12.4 0.5 4.3 4 0 0 4 4 4 0 Spt20 family Coiled PF05710.12 CDI82639.1 - 5.3 7.9 27.1 0.21 12.5 10.6 3.5 3 0 0 3 3 3 0 Coiled coil GTP_EFTU PF00009.27 CDI82640.1 - 4.4e-57 192.8 0.0 9.1e-57 191.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDI82640.1 - 1.5e-42 144.2 0.1 3.3e-42 143.1 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CDI82640.1 - 8e-25 86.7 0.0 1.4e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDI82640.1 - 3.3e-19 68.7 0.0 1.5e-18 66.6 0.0 2.1 1 1 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDI82640.1 - 1.1e-10 41.7 0.1 3e-10 40.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 AIG1 PF04548.16 CDI82640.1 - 0.09 12.1 0.0 5 6.4 0.0 2.2 2 0 0 2 2 2 0 AIG1 family RF3_C PF16658.5 CDI82640.1 - 0.11 12.4 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain DUF572 PF04502.13 CDI82641.1 - 0.013 15.1 4.6 0.02 14.5 4.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) TFIIA PF03153.13 CDI82641.1 - 0.022 14.8 21.8 0.03 14.3 21.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI82641.1 - 0.027 12.8 10.7 0.028 12.7 10.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SUIM_assoc PF16619.5 CDI82641.1 - 0.038 14.1 3.1 0.038 14.1 3.1 3.1 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF2845 PF11006.8 CDI82641.1 - 1.2 9.3 5.8 0.63 10.2 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2845) BRF1 PF07741.13 CDI82641.1 - 1.2 9.5 9.3 2.4 8.5 0.0 2.8 3 0 0 3 3 3 0 Brf1-like TBP-binding domain RED_N PF07808.13 CDI82641.1 - 1.5 8.4 7.7 2.5 7.6 7.7 1.4 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF1387 PF07139.11 CDI82641.1 - 7.6 6.2 10.6 13 5.4 10.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Pkinase PF00069.25 CDI82642.1 - 7.8e-65 218.9 0.0 1.6e-64 217.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82642.1 - 4.5e-37 127.7 0.0 9.7e-37 126.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI82642.1 - 9.6e-05 21.8 0.1 0.00025 20.5 0.0 1.7 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDI82642.1 - 0.00042 20.0 0.2 0.76 9.3 0.1 2.2 1 1 0 2 2 2 2 RIO1 family DUF2252 PF10009.9 CDI82642.1 - 0.002 17.2 0.1 0.0032 16.6 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) APH PF01636.23 CDI82642.1 - 0.0021 18.0 1.4 0.034 14.0 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CDI82642.1 - 0.019 14.3 0.7 0.18 11.1 0.0 2.4 2 1 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family Presenilin PF01080.17 CDI82642.1 - 0.1 11.4 0.2 0.14 10.9 0.2 1.1 1 0 0 1 1 1 0 Presenilin YrbL-PhoP_reg PF10707.9 CDI82642.1 - 0.11 12.0 0.3 3.3 7.2 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Act-Frag_cataly PF09192.10 CDI82642.1 - 0.54 9.6 2.3 0.5 9.7 0.1 1.8 2 0 0 2 2 2 0 Actin-fragmin kinase, catalytic EMP24_GP25L PF01105.24 CDI82643.1 - 1.4e-22 80.5 0.0 2.6e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD NUFIP2 PF15293.6 CDI82644.1 - 2.3 7.0 7.6 3 6.6 7.6 1.1 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 Peptidase_M24 PF00557.24 CDI82645.1 - 4.3e-06 26.6 0.1 0.0017 18.1 0.1 2.3 1 1 1 2 2 2 2 Metallopeptidase family M24 PE_PPE_C PF12484.8 CDI82645.1 - 0.043 14.7 10.6 0.043 14.7 10.6 2.9 2 1 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal Spt20 PF12090.8 CDI82649.1 - 0.19 11.3 12.8 0.21 11.2 12.8 1.0 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI82649.1 - 2.3 7.3 9.9 2.7 7.1 9.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Roughex PF06020.11 CDI82649.1 - 3 6.9 9.1 3.3 6.7 9.1 1.0 1 0 0 1 1 1 0 Drosophila roughex protein Paf1 PF03985.13 CDI82649.1 - 5.5 5.9 11.5 5.9 5.8 11.5 1.0 1 0 0 1 1 1 0 Paf1 DUF4834 PF16118.5 CDI82649.1 - 8.8 7.4 8.4 11 7.1 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TRAPP PF04051.16 CDI82655.1 - 3.5e-25 88.4 0.0 2.5e-24 85.7 0.0 2.0 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component C_GCAxxG_C_C PF09719.10 CDI82655.1 - 0.0011 19.2 0.2 0.0045 17.2 0.2 2.1 1 0 0 1 1 1 1 Putative redox-active protein (C_GCAxxG_C_C) Utp14 PF04615.13 CDI82655.1 - 0.11 11.1 8.2 0.16 10.5 8.2 1.2 1 0 0 1 1 1 0 Utp14 protein CDT1 PF08839.11 CDI82655.1 - 0.17 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 DNA replication factor CDT1 like Apt1 PF10351.9 CDI82655.1 - 5.4 5.7 41.8 0.11 11.4 9.6 2.1 1 1 0 2 2 2 0 Golgi-body localisation protein domain Sec3_C PF09763.9 CDI82655.1 - 7.6 4.8 15.9 0.25 9.7 2.3 2.1 2 0 0 2 2 2 0 Exocyst complex component Sec3 DUF2722 PF10846.8 CDI82656.1 - 0.005 15.8 5.6 0.0067 15.4 5.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI82656.1 - 0.033 13.8 17.5 0.058 13.0 17.5 1.3 1 0 0 1 1 1 0 Spt20 family Hid1 PF12722.7 CDI82656.1 - 0.11 10.6 2.3 0.15 10.2 2.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Roughex PF06020.11 CDI82656.1 - 1.4 7.9 8.4 2.2 7.3 8.4 1.4 1 0 0 1 1 1 0 Drosophila roughex protein RdRP PF05183.12 CDI82657.1 - 2e-15 56.5 10.7 4.6e-09 35.5 0.0 3.7 4 0 0 4 4 4 3 RNA dependent RNA polymerase GTP_EFTU PF00009.27 CDI82659.1 - 2.7e-18 66.2 0.0 2.7e-18 66.2 0.0 2.5 2 1 0 3 3 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDI82659.1 - 1.5e-08 34.7 0.0 1.4e-07 31.6 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase IF-2 PF11987.8 CDI82659.1 - 0.00011 22.3 0.0 0.00043 20.4 0.0 2.1 1 0 0 1 1 1 1 Translation-initiation factor 2 Ras PF00071.22 CDI82659.1 - 0.0017 18.0 0.0 0.0099 15.5 0.0 2.2 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 CDI82659.1 - 0.0023 17.4 0.1 0.054 12.9 0.1 2.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Spt20 PF12090.8 CDI82659.1 - 0.0038 16.9 8.5 0.0038 16.9 8.5 6.1 5 1 0 5 5 4 2 Spt20 family Arf PF00025.21 CDI82659.1 - 0.0054 16.2 0.0 0.061 12.8 0.0 2.6 3 0 0 3 3 3 1 ADP-ribosylation factor family NOG1 PF06858.14 CDI82659.1 - 0.0057 16.4 0.4 0.016 15.0 0.4 1.8 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) Roc PF08477.13 CDI82659.1 - 0.0078 16.4 6.9 0.11 12.8 0.0 3.4 2 2 2 4 4 4 2 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 CDI82659.1 - 0.017 14.7 0.2 0.017 14.7 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 CDI82659.1 - 0.023 14.2 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Pyridoxal_deC PF00282.19 CDI82659.1 - 0.03 13.0 0.0 0.076 11.7 0.0 1.7 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Abhydrolase_2 PF02230.16 CDI82660.1 - 8.5e-37 127.1 0.0 1.5e-32 113.1 0.0 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 CDI82660.1 - 1.4e-07 31.4 1.6 2.6e-06 27.2 0.1 2.8 1 1 1 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 CDI82660.1 - 0.00014 22.5 0.0 0.00017 22.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDI82660.1 - 0.0046 16.3 0.9 0.082 12.2 0.0 3.0 2 1 2 4 4 4 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CDI82660.1 - 0.0079 16.1 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DNAP_B_exo_N PF08452.10 CDI82660.1 - 0.19 11.1 0.7 0.47 9.9 0.2 1.9 2 0 0 2 2 2 0 DNA polymerase family B exonuclease domain, N-terminal RskA PF10099.9 CDI82666.1 - 0.0011 19.3 0.0 0.0011 19.3 0.0 5.3 3 2 1 5 5 5 2 Anti-sigma-K factor rskA DUF418 PF04235.12 CDI82667.1 - 0.04 13.8 0.6 0.9 9.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF418) Cyt_bd_oxida_II PF02322.15 CDI82667.1 - 0.13 11.6 1.2 1.5 8.1 2.2 1.9 1 1 1 2 2 2 0 Cytochrome bd terminal oxidase subunit II AAA_2 PF07724.14 CDI82674.1 - 2e-34 119.2 0.1 2e-33 115.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 CDI82674.1 - 8.2e-09 35.4 0.0 1.9e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDI82674.1 - 1.7e-06 28.5 0.0 3.8e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDI82674.1 - 2.5e-06 27.5 0.1 9.2e-06 25.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI82674.1 - 0.00021 21.9 0.0 0.0048 17.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CDI82674.1 - 0.00022 21.0 0.0 0.00044 20.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 CDI82674.1 - 0.013 14.8 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_3 PF07726.11 CDI82674.1 - 0.02 14.8 0.0 8.1 6.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI82674.1 - 0.029 14.6 0.1 1.2 9.4 0.1 2.5 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDI82674.1 - 0.03 14.4 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDI82674.1 - 0.035 14.5 0.2 0.53 10.7 0.2 2.4 1 1 0 1 1 1 0 RNA helicase TFIIA PF03153.13 CDI82676.1 - 0.004 17.2 20.9 0.006 16.6 20.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Red1 PF07964.11 CDI82676.1 - 0.47 8.6 12.2 0.61 8.3 12.2 1.0 1 0 0 1 1 1 0 Rec10 / Red1 GREB1 PF15782.5 CDI82676.1 - 1.6 5.7 23.6 1.8 5.5 23.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TCP PF03634.13 CDI82676.1 - 6.8 7.2 21.0 10 6.7 4.9 2.2 2 0 0 2 2 2 0 TCP family transcription factor BT1 PF03092.16 CDI82683.1 - 3.8e-15 55.1 0.1 4.8e-15 54.8 0.1 1.1 1 0 0 1 1 1 1 BT1 family UL16 PF17622.2 CDI82683.1 - 0.016 14.9 0.2 0.033 13.8 0.2 1.6 1 1 0 1 1 1 0 Viral unique long protein 16 LssY_C PF14067.6 CDI82683.1 - 0.035 13.7 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 LssY C-terminus DUF4995 PF16386.5 CDI82683.1 - 0.087 12.8 3.2 3.4 7.7 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function RisS_PPD PF16524.5 CDI82693.1 - 0.084 13.1 0.9 0.16 12.2 0.9 1.4 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS Presenilin PF01080.17 CDI82693.1 - 7.2 5.3 5.4 9.9 4.8 5.4 1.1 1 0 0 1 1 1 0 Presenilin HSP70 PF00012.20 CDI82700.1 - 7.7e-42 143.3 0.0 9.8e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.16 CDI82700.1 - 0.021 14.6 0.3 0.034 13.9 0.3 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Actin PF00022.19 CDI82700.1 - 0.082 11.5 0.0 0.14 10.7 0.0 1.3 1 0 0 1 1 1 0 Actin Band_7 PF01145.25 CDI82703.1 - 1.9e-12 47.5 3.0 1.9e-12 47.5 3.0 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family Guanylate_cyc_2 PF09778.9 CDI82703.1 - 0.084 12.2 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Guanylylate cyclase SUIM_assoc PF16619.5 CDI82704.1 - 0.082 13.0 13.4 0.084 12.9 13.4 1.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI82705.1 - 0.0031 17.6 47.0 0.0039 17.3 47.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit MCM_bind PF09739.9 CDI82705.1 - 0.0072 14.8 16.9 0.0077 14.7 16.9 1.2 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor eIF-3_zeta PF05091.12 CDI82705.1 - 0.014 14.4 24.9 0.016 14.2 24.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 CDI82705.1 - 0.05 11.5 34.1 0.06 11.3 34.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SprA-related PF12118.8 CDI82705.1 - 0.057 12.6 44.1 0.083 12.0 44.1 1.2 1 0 0 1 1 1 0 SprA-related family Nop53 PF07767.11 CDI82705.1 - 0.092 12.1 27.5 0.12 11.8 27.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PAT1 PF09770.9 CDI82705.1 - 0.096 11.0 32.2 0.1 10.8 32.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CDC45 PF02724.14 CDI82705.1 - 0.17 10.2 22.0 0.21 9.9 22.0 1.1 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI82705.1 - 0.36 9.8 22.4 0.41 9.6 22.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S15 PF02129.18 CDI82705.1 - 0.36 10.4 15.5 0.47 10.0 15.5 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) SMYLE_N PF18615.1 CDI82705.1 - 0.42 10.1 22.8 0.66 9.5 22.8 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SID-1_RNA_chan PF13965.6 CDI82705.1 - 0.66 8.3 9.2 0.81 8.0 9.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Rrn6 PF10214.9 CDI82705.1 - 0.72 8.3 29.2 0.87 8.0 29.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Med15 PF09606.10 CDI82705.1 - 0.73 8.5 38.7 0.79 8.3 38.7 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RR_TM4-6 PF06459.12 CDI82705.1 - 0.91 9.3 27.9 1.1 9.0 27.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CAC1F_C PF16885.5 CDI82705.1 - 1.4 8.5 23.9 1.8 8.1 23.9 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Hamartin PF04388.12 CDI82705.1 - 1.4 7.5 28.6 1.9 7.0 28.6 1.1 1 0 0 1 1 1 0 Hamartin protein DDRGK PF09756.9 CDI82705.1 - 2.8 7.5 25.9 3.8 7.1 25.9 1.2 1 0 0 1 1 1 0 DDRGK domain PA26 PF04636.13 CDI82705.1 - 4.9 6.0 17.4 5.7 5.7 17.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) VIR_N PF15912.5 CDI82705.1 - 5.3 6.5 13.4 6.4 6.3 13.4 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal LAP1C PF05609.12 CDI82705.1 - 6.1 5.8 30.6 8.9 5.3 30.6 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ribosomal_60s PF00428.19 CDI82710.1 - 3.2 8.4 17.1 0.26 11.9 2.8 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein TCTP PF00838.17 CDI82713.1 - 2.1e-54 184.3 0.7 2.4e-54 184.1 0.7 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein URO-D PF01208.17 CDI82713.1 - 0.19 10.9 0.0 0.23 10.5 0.0 1.1 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) tRNA-synt_2b PF00587.25 CDI82716.1 - 4.9e-33 114.6 0.1 8.9e-32 110.5 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CDI82716.1 - 6e-20 71.5 1.2 1.5e-19 70.2 1.2 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain F-box-like PF12937.7 CDI82717.1 - 0.01 15.7 1.3 0.025 14.5 1.3 1.7 1 0 0 1 1 1 0 F-box-like RNA_pol_Rpb8 PF03870.15 CDI82718.1 - 2.7e-38 131.3 0.1 3.1e-38 131.1 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 CDI82718.1 - 2.7e-06 27.4 0.1 1.9e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G Pkinase PF00069.25 CDI82719.1 - 1.7e-39 135.8 0.0 3.2e-39 134.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI82719.1 - 2.8e-16 59.6 0.0 4.7e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SARAF PF06682.12 CDI82720.1 - 7.3 6.1 26.8 2 8.0 6.9 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis eIF-3_zeta PF05091.12 CDI82720.1 - 7.9 5.3 17.0 13 4.6 17.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Hydrolase PF00702.26 CDI82721.1 - 4.1e-16 59.9 5.5 4.3e-07 30.4 0.1 3.8 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI82721.1 - 9.5e-14 51.3 0.0 3.7e-08 33.3 0.0 2.6 2 0 0 2 2 2 2 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDI82721.1 - 2.9e-11 43.2 0.5 1.1e-10 41.4 0.5 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDI82721.1 - 0.0041 16.9 0.4 0.041 13.6 0.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SR-25 PF10500.9 CDI82721.1 - 5.4 6.6 27.6 1.1 8.8 2.4 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein BAF1_ABF1 PF04684.13 CDI82724.1 - 2.2 7.2 4.3 3.9 6.4 4.3 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Syja_N PF02383.18 CDI82725.1 - 3.6e-54 184.2 0.0 5.1e-53 180.4 0.0 2.2 1 1 0 1 1 1 1 SacI homology domain DUF4667 PF15700.5 CDI82725.1 - 0.00095 19.3 24.5 0.012 15.7 5.0 4.1 4 0 0 4 4 4 3 Domain of unknown function (DUF4667) SPX PF03105.19 CDI82725.1 - 0.0056 16.7 8.6 0.018 15.0 2.9 2.9 3 0 0 3 3 3 1 SPX domain MID_MedPIWI PF18296.1 CDI82725.1 - 0.027 14.3 8.6 0.066 13.0 1.1 3.0 3 0 0 3 3 3 0 MID domain of medPIWI HMMR_N PF15905.5 CDI82725.1 - 0.41 10.1 2.0 0.87 9.0 2.0 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Secretin_N_2 PF07655.13 CDI82725.1 - 2 9.0 44.8 3.2 8.4 0.3 4.4 4 0 0 4 4 4 0 Secretin N-terminal domain MMS1_N PF10433.9 CDI82726.1 - 2.2e-24 86.0 1.2 4.7e-23 81.6 0.1 2.3 2 0 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CDI82726.1 - 6.2e-20 71.8 0.0 9e-12 44.9 0.0 3.3 3 0 0 3 3 3 3 CPSF A subunit region SR-25 PF10500.9 CDI82726.1 - 4.7e-05 23.1 9.4 4.7e-05 23.1 9.4 13.1 13 1 0 13 13 13 4 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI82726.1 - 5.3 6.7 21.9 6.9 6.3 0.1 5.7 5 0 0 5 5 5 0 Cwf15/Cwc15 cell cycle control protein DUF1117 PF06547.12 CDI82728.1 - 0.26 11.9 2.3 0.63 10.6 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) DctQ PF04290.12 CDI82728.1 - 0.34 10.8 4.7 1.1 9.2 0.3 2.7 3 0 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component GREB1 PF15782.5 CDI82728.1 - 0.62 7.1 5.3 0.72 6.9 5.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer UBA2_C PF16195.5 CDI82728.1 - 8.6 7.1 9.5 0.21 12.3 1.5 2.1 1 1 1 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Octopine_DH PF02317.17 CDI82731.1 - 1.4e-30 106.4 0.0 1.8e-30 106.0 0.0 1.1 1 0 0 1 1 1 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain DUF1471 PF07338.13 CDI82734.1 - 0.05 13.6 1.1 0.05 13.6 1.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1471) BUD22 PF09073.10 CDI82738.1 - 0.00019 21.0 21.7 0.0002 20.9 21.7 1.1 1 0 0 1 1 1 1 BUD22 Rib_recp_KP_reg PF05104.12 CDI82738.1 - 0.0031 18.6 5.1 0.0031 18.6 5.1 1.6 2 0 0 2 2 1 1 Ribosome receptor lysine/proline rich region SAPS PF04499.15 CDI82738.1 - 0.0078 15.1 13.9 0.0093 14.8 13.9 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein RXT2_N PF08595.11 CDI82738.1 - 0.017 15.1 29.0 0.08 13.0 11.1 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal PTPRCAP PF15713.5 CDI82738.1 - 0.02 15.2 8.7 0.02 15.2 8.7 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated BSMAP PF12280.8 CDI82738.1 - 0.023 14.9 0.6 0.023 14.9 0.6 1.7 2 0 0 2 2 2 0 Brain specific membrane anchored protein SURF2 PF05477.11 CDI82738.1 - 0.075 12.7 13.6 0.14 11.8 13.6 1.4 1 1 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Vfa1 PF08432.10 CDI82738.1 - 0.63 10.4 20.7 0.49 10.7 9.3 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF4611 PF15387.6 CDI82738.1 - 1.2 9.4 29.4 1.8 8.9 12.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nop25 PF09805.9 CDI82738.1 - 1.3 9.4 24.8 2.4 8.6 11.4 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) SpoIIIAH PF12685.7 CDI82738.1 - 2.1 8.1 15.9 0.8 9.5 6.3 2.1 2 0 0 2 2 2 0 SpoIIIAH-like protein NOA36 PF06524.12 CDI82738.1 - 2.4 7.4 42.2 3.5 6.9 14.0 2.1 2 0 0 2 2 2 0 NOA36 protein RNA_pol_Rpc4 PF05132.14 CDI82738.1 - 8.5 6.8 11.2 24 5.3 5.9 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 DHR10 PF18595.1 CDI82750.1 - 0.021 14.9 2.6 0.045 13.8 0.8 2.3 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain DUF4089 PF13318.6 CDI82750.1 - 0.036 14.5 0.7 0.036 14.5 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4089) TipAS PF07739.13 CDI82750.1 - 0.11 13.0 0.1 0.53 10.8 0.1 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain DELLA PF12041.8 CDI82750.1 - 0.13 12.1 0.2 0.35 10.8 0.2 1.8 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal Inhibitor_I53 PF11714.8 CDI82750.1 - 0.2 11.8 0.8 2 8.7 0.1 2.2 2 0 0 2 2 2 0 Thrombin inhibitor Madanin CLZ PF16526.5 CDI82750.1 - 0.79 10.1 4.1 0.75 10.2 1.3 2.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Presenilin PF01080.17 CDI82751.1 - 5.4 5.7 4.8 7.7 5.2 4.8 1.1 1 0 0 1 1 1 0 Presenilin Tim17 PF02466.19 CDI82752.1 - 6.4e-16 58.7 0.1 1.1e-15 57.9 0.1 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HA2 PF04408.23 CDI82753.1 - 1e-10 41.8 0.4 3.4e-10 40.2 0.1 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI82753.1 - 4.8e-07 30.0 0.0 1.6e-06 28.4 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold SR-25 PF10500.9 CDI82753.1 - 0.026 14.1 7.7 0.07 12.7 7.7 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PLL PF18587.1 CDI82754.1 - 0.015 15.4 0.1 0.026 14.6 0.1 1.4 1 0 0 1 1 1 0 PTX/LNS-Like (PLL) domain CRAL_TRIO PF00650.20 CDI82755.1 - 5.1e-18 65.3 0.0 7.8e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Glyco_transf_10 PF00852.19 CDI82755.1 - 0.19 11.4 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 10 (fucosyltransferase) C-term Popeye PF04831.13 CDI82757.1 - 1.6e-11 44.6 0.0 2.5e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 CDI82757.1 - 0.00058 19.9 0.7 0.036 14.2 0.0 3.0 3 0 0 3 3 3 1 Cyclic nucleotide-binding domain Methyltr_RsmB-F PF01189.17 CDI82759.1 - 1.2e-24 87.1 0.0 3.7e-16 59.4 0.0 3.7 3 1 0 3 3 3 3 16S rRNA methyltransferase RsmB/F ABC2_membrane PF01061.24 CDI82760.1 - 4.3e-22 78.6 20.0 4.3e-22 78.6 20.0 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 CDI82760.1 - 1.8e-09 38.2 0.0 2.9e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CDI82760.1 - 0.00023 20.4 15.5 0.00023 20.4 15.5 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein DEAD PF00270.29 CDI82761.1 - 1.5e-08 34.6 0.0 3.5e-05 23.6 0.0 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CDI82761.1 - 1.1e-07 32.2 0.0 4.1e-06 27.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Trs65 PF12735.7 CDI82762.1 - 9.7e-06 25.2 0.0 0.0023 17.4 0.0 2.1 2 0 0 2 2 2 2 TRAPP trafficking subunit Trs65 DUF3122 PF11320.8 CDI82762.1 - 0.045 13.8 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) Peptidase_M16 PF00675.20 CDI82763.1 - 7.1e-43 146.1 0.1 7.1e-43 146.1 0.1 2.6 3 1 1 4 4 4 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDI82763.1 - 2.3e-30 106.0 0.0 1.2e-18 67.8 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16_M PF16187.5 CDI82763.1 - 4.1e-30 105.0 0.0 1.1e-28 100.3 0.0 2.3 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Asp PF00026.23 CDI82764.1 - 5.6e-44 150.8 0.0 7.3e-35 120.9 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDI82764.1 - 9.9e-13 48.7 0.0 5.4e-10 39.8 0.0 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Amidohydro_2 PF04909.14 CDI82766.1 - 3.1e-07 30.5 0.0 4.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Mu-like_Com PF10122.9 CDI82766.1 - 0.14 11.6 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Mu-like prophage protein Com V-SNARE_C PF12352.8 CDI82767.1 - 1.4e-08 34.9 2.3 1.4e-08 34.9 2.3 1.8 1 1 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus AsnA PF03590.15 CDI82767.1 - 0.0095 15.7 2.3 0.027 14.2 0.6 2.1 1 1 1 2 2 2 1 Aspartate-ammonia ligase Ribosomal_L28 PF00830.19 CDI82768.1 - 1.7e-06 28.1 1.2 2.9e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Ribosomal L28 family Microtub_bind PF13931.6 CDI82769.1 - 0.14 12.5 1.9 0.43 11.0 1.9 1.8 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Phasin PF05597.11 CDI82769.1 - 1.3 9.1 10.4 0.39 10.7 0.7 3.2 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Histone_HNS PF00816.21 CDI82769.1 - 3.8 8.4 12.7 5.8 7.8 3.1 3.4 4 0 0 4 4 4 0 H-NS histone family Connexin PF00029.19 CDI82770.1 - 0.4 10.4 1.7 0.54 10.0 1.7 1.3 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 CDI82770.1 - 0.45 10.3 5.6 0.8 9.5 5.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 CDI82770.1 - 1 8.3 10.1 1.5 7.8 10.1 1.1 1 0 0 1 1 1 0 Paf1 TFIIA PF03153.13 CDI82770.1 - 4.3 7.2 28.3 1.5 8.7 24.8 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 CDI82771.1 - 0.0046 15.3 15.2 0.0048 15.3 15.2 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI82771.1 - 5.2 7.0 42.5 10 6.0 42.5 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RrnaAD PF00398.20 CDI82772.1 - 2.1e-22 79.5 0.0 2.5e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PRMT5 PF05185.16 CDI82788.1 - 2.3e-41 141.5 1.8 8.7e-27 94.1 0.0 4.3 3 1 0 3 3 3 2 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 CDI82788.1 - 2.4e-31 108.9 2.9 1e-27 97.0 0.7 3.7 2 0 0 2 2 2 2 PRMT5 TIM barrel domain DEAD_2 PF06733.15 CDI82788.1 - 9.3e-25 87.2 0.0 5.8e-15 55.3 0.0 4.3 2 1 0 2 2 2 2 DEAD_2 RskA PF10099.9 CDI82788.1 - 0.0033 17.7 11.4 0.0033 17.7 11.4 30.4 14 9 9 24 24 24 2 Anti-sigma-K factor rskA HBB PF06777.11 CDI82788.1 - 0.045 13.4 9.1 0.28 10.9 4.8 3.1 2 1 0 2 2 2 0 Helical and beta-bridge domain SARAF PF06682.12 CDI82789.1 - 0.00026 20.8 0.1 0.0003 20.5 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Dehydrin PF00257.19 CDI82789.1 - 0.016 15.8 0.4 0.016 15.7 0.4 1.2 1 0 0 1 1 1 0 Dehydrin Use1 PF09753.9 CDI82789.1 - 0.023 14.4 0.0 0.023 14.4 0.0 2.2 1 1 1 2 2 2 0 Membrane fusion protein Use1 Phage_holin_3_6 PF07332.11 CDI82789.1 - 0.093 12.8 8.8 0.13 12.3 8.7 1.4 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RskA PF10099.9 CDI82789.1 - 2.4 8.4 13.0 3.9 7.7 13.0 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI82789.1 - 2.9 8.0 14.1 6.7 6.9 14.1 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DnaJ_C PF01556.18 CDI82793.1 - 1.3e-31 109.7 0.0 2.7e-31 108.6 0.0 1.5 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 CDI82793.1 - 2.4e-07 31.0 13.8 4.9e-07 30.0 13.8 1.6 1 0 0 1 1 1 1 DnaJ central domain PHD_4 PF16866.5 CDI82793.1 - 0.018 15.1 0.3 0.05 13.7 0.3 1.7 1 0 0 1 1 1 0 PHD-finger HypA PF01155.19 CDI82793.1 - 2.8 8.0 8.2 3.6e+02 1.2 8.2 2.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 CDI82793.1 - 6.2 6.9 12.2 19 5.4 12.2 1.8 1 1 0 1 1 1 0 Double zinc ribbon Anti-TRAP PF15777.5 CDI82793.1 - 8.3 6.5 12.1 0.84 9.6 4.0 2.7 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cation_ATPase_C PF00689.21 CDI82805.1 - 2.4e-52 177.3 2.1 5.6e-52 176.1 2.1 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CDI82805.1 - 4.4e-51 173.0 3.0 6.7e-50 169.1 0.3 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDI82805.1 - 7.6e-20 72.1 4.2 1.4e-17 64.7 0.1 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDI82805.1 - 8.4e-20 70.2 0.1 4.2e-19 68.0 0.1 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CDI82805.1 - 1.6e-19 69.8 0.0 3.1e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CDI82805.1 - 1.4e-05 24.9 0.5 7.5e-05 22.6 0.5 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDI82805.1 - 0.0024 18.3 0.0 0.017 15.5 0.0 2.4 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDI82805.1 - 0.18 12.0 0.0 0.67 10.1 0.0 2.0 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase TMEM208_SND2 PF05620.11 CDI82805.1 - 3.6 7.3 4.5 8.1 6.2 0.1 2.5 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 DUF1600 PF07667.11 CDI82806.1 - 0.42 10.8 3.4 0.79 10.0 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) Methyltrans_RNA PF04452.14 CDI82807.1 - 2.3e-30 105.6 0.0 1.1e-14 54.3 0.0 2.2 2 0 0 2 2 2 2 RNA methyltransferase AbiEi_3 PF11459.8 CDI82807.1 - 0.0033 17.2 0.1 0.0072 16.0 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator, AbiEi antitoxin, Type IV TA system Presenilin PF01080.17 CDI82807.1 - 0.82 8.4 4.0 2.9 6.6 0.8 2.1 2 0 0 2 2 2 0 Presenilin Ribosomal_60s PF00428.19 CDI82807.1 - 1.2 9.8 25.3 1.9 9.1 1.5 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein RsfS PF02410.15 CDI82808.1 - 4.6e-14 52.6 0.0 1.2e-13 51.3 0.0 1.8 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation zf-RING_5 PF14634.6 CDI82809.1 - 0.00032 20.6 7.6 0.00032 20.6 7.6 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDI82809.1 - 0.0047 16.8 7.5 0.0047 16.8 7.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RAP PF08373.10 CDI82810.1 - 3.7e-17 62.2 0.0 5.9e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 RAP domain MTES_1575 PF18741.1 CDI82810.1 - 0.022 14.9 0.2 0.056 13.6 0.1 1.7 2 0 0 2 2 2 0 REase_MTES_1575 Chorion_S16 PF05836.12 CDI82810.1 - 0.12 12.6 0.2 0.28 11.4 0.2 1.5 1 0 0 1 1 1 0 Chorion protein S16 CDPS PF16715.5 CDI82811.1 - 0.02 14.5 0.6 0.02 14.5 0.6 2.6 2 1 1 3 3 3 0 Cyclodipeptide synthase TFIIA PF03153.13 CDI82811.1 - 0.11 12.5 14.0 0.14 12.2 14.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GNAT_acetyltr_2 PF13718.6 CDI82812.1 - 4.3e-56 189.9 3.5 2.9e-31 108.6 0.1 2.9 1 1 2 3 3 3 2 GNAT acetyltransferase 2 Acetyltransf_1 PF00583.25 CDI82812.1 - 0.00014 22.1 0.0 0.00037 20.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family LCD1 PF09798.9 CDI82812.1 - 0.0013 17.4 5.4 0.0014 17.3 5.4 1.1 1 0 0 1 1 1 1 DNA damage checkpoint protein Acetyltransf_7 PF13508.7 CDI82812.1 - 0.0049 17.3 0.1 0.018 15.4 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain CDC45 PF02724.14 CDI82812.1 - 0.0085 14.4 5.8 0.01 14.2 5.8 1.1 1 0 0 1 1 1 1 CDC45-like protein Cwf_Cwc_15 PF04889.12 CDI82812.1 - 0.021 14.5 16.9 0.029 14.1 16.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Presenilin PF01080.17 CDI82812.1 - 0.062 12.1 9.5 0.077 11.8 9.5 1.1 1 0 0 1 1 1 0 Presenilin Med8 PF10232.9 CDI82812.1 - 0.089 12.4 8.2 0.12 12.0 8.2 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 CDC27 PF09507.10 CDI82812.1 - 0.1 12.0 20.0 0.15 11.5 20.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop53 PF07767.11 CDI82812.1 - 0.11 11.9 28.1 0.15 11.4 28.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Borrelia_P83 PF05262.11 CDI82812.1 - 0.11 10.9 12.4 0.14 10.6 12.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SRP-alpha_N PF04086.13 CDI82812.1 - 0.34 10.8 15.3 0.46 10.4 15.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 CDI82812.1 - 0.44 9.2 6.7 0.47 9.1 6.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spt20 PF12090.8 CDI82812.1 - 0.69 9.5 14.2 1.1 8.8 14.2 1.3 1 0 0 1 1 1 0 Spt20 family DUF4407 PF14362.6 CDI82812.1 - 0.71 9.2 25.6 1 8.7 25.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAPS PF04499.15 CDI82812.1 - 1 8.0 9.1 1.3 7.7 9.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 CDI82812.1 - 1.4 7.9 5.9 1.9 7.4 5.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PGA2 PF07543.12 CDI82812.1 - 2.4 8.1 21.4 4.4 7.3 21.4 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 TMEM215 PF15746.5 CDI82812.1 - 2.7 7.4 5.9 3.1 7.2 5.2 1.5 2 0 0 2 2 2 0 TMEM215 family Zip PF02535.22 CDI82812.1 - 4.5 6.4 5.4 6.1 6.0 5.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 CDI82812.1 - 4.9 6.9 18.6 8.5 6.1 18.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI82812.1 - 5.1 5.1 14.1 6.4 4.8 14.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PA26 PF04636.13 CDI82812.1 - 5.3 5.9 8.0 7 5.5 8.0 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Raftlin PF15250.6 CDI82812.1 - 5.7 5.6 12.8 7.9 5.1 12.8 1.1 1 0 0 1 1 1 0 Raftlin Allexi_40kDa PF05549.11 CDI82812.1 - 6.2 6.2 10.2 3.2 7.2 7.6 1.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein ALMT PF11744.8 CDI82812.1 - 7.6 5.2 8.0 9.9 4.9 8.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 CDI82812.1 - 9.8 5.1 13.7 14 4.6 13.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 polyprenyl_synt PF00348.17 CDI82822.1 - 0.05 12.6 0.0 0.05 12.6 0.0 1.0 1 0 0 1 1 1 0 Polyprenyl synthetase Integrase_H2C2 PF17921.1 CDI82826.1 - 4.1e-16 58.8 0.3 9.1e-16 57.7 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDI82826.1 - 3.8e-06 27.1 0.0 8.1e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDI82826.1 - 0.009 16.2 0.1 0.024 14.9 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH PF17917.1 CDI82826.1 - 0.037 14.3 0.1 0.08 13.2 0.1 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Rhodanese PF00581.20 CDI82828.1 - 0.033 14.7 0.0 0.25 11.9 0.0 2.5 3 0 0 3 3 3 0 Rhodanese-like domain TFIIA PF03153.13 CDI82828.1 - 1.5 8.7 77.6 0.14 12.1 15.0 3.9 3 2 1 4 4 4 0 Transcription factor IIA, alpha/beta subunit Nop25 PF09805.9 CDI82829.1 - 8.2e-10 39.3 15.0 8.2e-10 39.3 15.0 1.7 1 1 1 2 2 2 1 Nucleolar protein 12 (25kDa) MSA-2c PF12238.8 CDI82830.1 - 4.6 7.2 9.8 5.9 6.8 9.8 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c EELM2 PF15863.5 CDI82831.1 - 4.6e-78 261.2 0.1 7.4e-78 260.6 0.1 1.3 1 0 0 1 1 1 1 Extended EGL-27 and MTA1 homology domain PHD PF00628.29 CDI82831.1 - 4.5e-08 32.8 6.4 4.5e-08 32.8 6.4 1.9 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 CDI82831.1 - 0.0034 17.0 3.7 0.022 14.4 1.2 2.7 3 0 0 3 3 3 1 PHD/FYVE-zinc-finger like domain Ribosomal_S17_N PF16205.5 CDI82832.1 - 9e-28 96.5 0.1 1.6e-27 95.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CDI82832.1 - 6.2e-23 80.7 1.5 9.3e-23 80.1 1.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S5 PF00333.20 CDI82833.1 - 1.4e-29 101.9 0.4 3.1e-29 100.7 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CDI82833.1 - 1.8e-23 81.7 0.0 3.5e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 CDI82833.1 - 5.9 7.5 10.1 14 6.3 10.1 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 NPV_P10 PF05531.12 CDI82835.1 - 0.0042 17.5 0.3 0.0084 16.6 0.3 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein WD40 PF00400.32 CDI82836.1 - 5.5e-24 84.0 6.7 8.7e-06 26.4 0.1 7.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI82836.1 - 4.3e-09 36.6 0.1 0.35 11.2 0.0 5.4 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDI82836.1 - 0.025 13.6 0.2 6.6 5.6 0.1 3.1 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 CDI82836.1 - 0.15 10.3 0.0 7.7 4.7 0.0 2.2 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz AAA PF00004.29 CDI82839.1 - 1.9e-15 57.5 0.0 3.6e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDI82839.1 - 5.3e-12 45.8 0.0 1.3e-10 41.3 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 CDI82839.1 - 2.5e-06 27.8 0.0 7.6e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_22 PF13401.6 CDI82839.1 - 4.3e-06 27.1 0.2 7.8e-05 23.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 CDI82839.1 - 6.6e-05 23.2 0.2 0.00041 20.6 0.1 2.2 2 0 0 2 2 2 1 AAA C-terminal domain AAA_30 PF13604.6 CDI82839.1 - 9.6e-05 22.2 0.0 0.00045 20.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 CDI82839.1 - 0.00021 20.8 0.0 0.00038 20.0 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_14 PF13173.6 CDI82839.1 - 0.00037 20.5 0.0 0.00069 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CDI82839.1 - 0.00048 19.5 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CDI82839.1 - 0.0011 19.3 0.2 0.032 14.6 0.0 2.7 2 2 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CDI82839.1 - 0.0013 18.7 0.1 0.011 15.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI82839.1 - 0.0041 17.7 0.0 0.0066 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CDI82839.1 - 0.0064 16.2 0.0 0.0094 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 CDI82839.1 - 0.0079 16.0 0.1 0.64 9.8 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_11 PF13086.6 CDI82839.1 - 0.012 15.5 0.2 0.064 13.0 0.1 2.5 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDI82839.1 - 0.013 15.9 0.1 0.11 12.9 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 CDI82839.1 - 0.015 15.0 0.0 0.042 13.6 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDI82839.1 - 0.03 13.7 0.0 0.14 11.5 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDI82839.1 - 0.039 14.1 0.1 0.072 13.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 CDI82839.1 - 0.058 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CDI82839.1 - 0.059 13.6 0.0 0.13 12.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 CDI82841.1 - 2.8e-66 222.8 0.1 4.4e-66 222.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDI82841.1 - 5.7e-31 106.8 0.0 4.8e-30 103.8 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 CDI82841.1 - 4.1e-19 68.4 0.0 9e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CDI82841.1 - 9.6e-15 54.4 0.0 2.5e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CDI82841.1 - 9.4e-12 45.2 0.1 2.2e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDI82841.1 - 5.7e-05 23.2 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 CDI82841.1 - 0.024 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Shikimate_DH PF01488.20 CDI82841.1 - 0.027 14.5 0.0 0.51 10.4 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase SRPRB PF09439.10 CDI82841.1 - 0.084 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Myosin_head PF00063.21 CDI82842.1 - 8.8e-182 605.9 0.3 1.1e-181 605.6 0.3 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 CDI82842.1 - 0.018 15.4 0.0 0.056 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDI82842.1 - 0.025 14.5 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CDI82842.1 - 0.043 14.1 0.0 0.18 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDI82842.1 - 0.078 13.4 0.0 0.39 11.1 0.0 2.3 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 CDI82842.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDI82842.1 - 0.15 12.1 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CbiA PF01656.23 CDI82842.1 - 0.18 11.9 0.7 0.53 10.3 0.7 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ank_2 PF12796.7 CDI82843.1 - 1.9e-30 105.2 0.0 1.1e-15 58.0 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDI82843.1 - 8e-16 57.9 0.3 1.9e-07 31.2 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI82843.1 - 4.8e-13 49.3 0.3 7.4e-10 39.2 0.0 3.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDI82843.1 - 1.6e-12 47.3 0.0 7.5e-06 26.2 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CDI82843.1 - 3.4e-11 42.3 0.1 0.0025 18.2 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat CagY_M PF07337.11 CDI82845.1 - 0.089 12.4 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 DC-EC Repeat DUF3886 PF13025.6 CDI82856.1 - 0.027 14.7 5.7 0.046 13.9 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) DUF241 PF03087.14 CDI82856.1 - 0.039 13.8 2.4 0.053 13.3 2.4 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function PDEase_I PF00233.19 CDI82856.1 - 0.061 13.0 2.2 0.14 11.9 0.2 2.0 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase HGTP_anticodon PF03129.20 CDI82857.1 - 1.2e-19 70.2 0.2 6.2e-19 68.0 0.0 2.1 2 1 0 2 2 2 1 Anticodon binding domain SR-25 PF10500.9 CDI82857.1 - 0.15 11.6 7.0 0.22 11.1 7.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 2-oxoacid_dh PF00198.23 CDI82860.1 - 2.4e-12 46.8 0.4 3.6e-12 46.3 0.4 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Apt1 PF10351.9 CDI82860.1 - 4.2 6.1 26.1 4.9 5.9 26.1 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI82860.1 - 6.4 5.4 12.3 7.6 5.2 12.3 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI82861.1 - 5.3 6.9 13.5 6.4 6.7 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI82862.1 - 2.7 6.5 57.1 3.5 6.1 57.1 1.1 1 0 0 1 1 1 0 Macoilin family TFIIS_M PF07500.14 CDI82864.1 - 2.5e-09 37.6 0.7 3.7e-08 33.8 0.1 3.2 1 1 1 2 2 2 1 Transcription factor S-II (TFIIS), central domain SR-25 PF10500.9 CDI82864.1 - 0.00012 21.8 2.4 0.00012 21.8 2.4 10.4 7 3 3 10 10 10 4 Nuclear RNA-splicing-associated protein FlaG PF03646.15 CDI82864.1 - 0.02 15.1 0.9 0.02 15.1 0.9 8.2 9 0 0 9 9 9 0 FlaG protein Chromo PF00385.24 CDI82865.1 - 1.3e-06 28.2 0.3 2.7e-06 27.2 0.3 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain BSP_II PF05432.11 CDI82865.1 - 2.2 7.9 25.8 5 6.7 25.8 1.6 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) ubiquitin PF00240.23 CDI82866.1 - 3.2e-08 33.2 0.2 1.1e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family UBA PF00627.31 CDI82866.1 - 1.8e-06 27.7 0.2 5.1e-06 26.3 0.2 1.9 1 0 0 1 1 1 1 UBA/TS-N domain LMBR1 PF04791.16 CDI82866.1 - 0.96 8.3 3.7 1.6 7.6 3.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein SWIB PF02201.18 CDI82867.1 - 1.2e-22 79.6 0.1 1.6e-22 79.1 0.1 1.2 1 0 0 1 1 1 1 SWIB/MDM2 domain RCC1 PF00415.18 CDI82868.1 - 5.4e-27 94.2 12.8 5.1e-09 36.6 0.3 5.9 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Myosin_head PF00063.21 CDI82868.1 - 3.2e-26 91.8 0.0 8.4e-13 47.4 0.0 3.0 3 0 0 3 3 3 3 Myosin head (motor domain) RCC1_2 PF13540.6 CDI82868.1 - 1.1e-08 34.7 24.1 1.2e-08 34.5 0.5 5.4 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 CDI82868.1 - 0.24 11.3 21.3 0.71 9.8 1.1 5.2 5 0 0 5 5 5 0 IQ calmodulin-binding motif Mannosyl_trans PF05007.13 CDI82869.1 - 5.5e-15 55.9 0.8 9.6e-15 55.1 0.8 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 CDI82869.1 - 3.6e-13 49.3 0.0 4.7e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 CDI82869.1 - 8.8e-05 22.3 7.9 8.8e-05 22.3 7.9 2.0 2 1 0 2 2 2 1 Glycosyltransferase family 87 ALG3 PF05208.13 CDI82869.1 - 0.031 13.7 2.9 1.9 7.8 0.1 2.3 2 0 0 2 2 2 0 ALG3 protein PMT_2 PF13231.6 CDI82869.1 - 0.034 14.4 3.3 0.077 13.2 3.3 1.6 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Asp5 PF17000.5 CDI82869.1 - 0.58 10.3 3.9 0.24 11.6 0.5 2.2 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 BTB PF00651.31 CDI82870.1 - 2.7e-06 27.6 0.0 5.7e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain FPL PF09758.9 CDI82872.1 - 4.6e-58 195.4 4.2 7.2e-58 194.8 4.2 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein TatD_DNase PF01026.21 CDI82878.1 - 5.5e-44 150.5 0.0 9.3e-44 149.7 0.0 1.4 1 0 0 1 1 1 1 TatD related DNase DUF4614 PF15391.6 CDI82878.1 - 0.015 15.3 8.2 0.015 15.3 8.2 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 CDI82878.1 - 0.14 10.9 22.1 0.55 9.0 4.1 2.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain Zip PF02535.22 CDI82878.1 - 0.15 11.2 2.3 1 8.5 0.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Spt20 PF12090.8 CDI82878.1 - 2.6 7.6 24.1 0.17 11.5 2.2 3.2 3 0 0 3 3 3 0 Spt20 family RskA PF10099.9 CDI82878.1 - 6.9 6.9 45.5 0.53 10.6 15.9 3.3 2 1 0 2 2 2 0 Anti-sigma-K factor rskA 5-FTHF_cyc-lig PF01812.20 CDI82879.1 - 0.11 12.4 0.3 0.55 10.1 0.0 2.4 2 0 0 2 2 2 0 5-formyltetrahydrofolate cyclo-ligase family NTF2 PF02136.20 CDI82880.1 - 5.2e-16 59.3 0.0 1.7e-15 57.7 0.0 2.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF2722 PF10846.8 CDI82880.1 - 0.0031 16.5 11.4 0.0031 16.5 11.4 6.3 2 1 4 6 6 6 1 Protein of unknown function (DUF2722) DUF4518 PF15008.6 CDI82880.1 - 0.0063 15.7 2.0 0.0063 15.7 2.0 4.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4518) AP2 PF00847.20 CDI82881.1 - 7.8e-09 35.6 0.1 1.9e-08 34.4 0.1 1.7 1 0 0 1 1 1 1 AP2 domain Pap_E4 PF02711.14 CDI82881.1 - 0.13 13.3 1.9 7.7 7.6 0.1 3.1 2 0 0 2 2 2 0 E4 protein C2 PF00168.30 CDI82883.1 - 1.8e-05 25.0 0.0 0.0013 19.0 0.0 2.8 3 0 0 3 3 3 1 C2 domain Ferlin_C PF16165.5 CDI82883.1 - 0.0031 17.5 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 Ferlin C-terminus AcylCoA_dehyd_C PF12186.8 CDI82883.1 - 0.21 11.7 0.2 0.43 10.7 0.2 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal SOG2 PF10428.9 CDI82884.1 - 8 5.5 16.6 12 5.0 16.6 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein H_PPase PF03030.16 CDI82885.1 - 7.7e-97 325.5 24.7 1.8e-95 321.0 24.7 2.0 1 1 0 1 1 1 1 Inorganic H+ pyrophosphatase SID-1_RNA_chan PF13965.6 CDI82887.1 - 0.014 13.8 3.4 0.015 13.7 3.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Folliculin PF11704.8 CDI82887.1 - 0.043 13.7 17.0 0.056 13.3 17.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport CobT PF06213.12 CDI82887.1 - 0.055 12.9 22.8 0.066 12.6 22.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SLC12 PF03522.15 CDI82887.1 - 0.1 11.6 16.6 0.12 11.3 16.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Dicty_REP PF05086.12 CDI82887.1 - 0.15 10.0 12.4 0.17 9.8 12.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RAG1_imp_bd PF12560.8 CDI82887.1 - 0.21 11.1 16.8 0.29 10.6 16.8 1.1 1 0 0 1 1 1 0 RAG1 importin binding Zip PF02535.22 CDI82887.1 - 0.25 10.5 8.2 0.31 10.2 8.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 CDI82887.1 - 0.37 9.0 16.6 0.46 8.7 16.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF5523 PF17661.1 CDI82887.1 - 0.45 10.1 22.4 0.59 9.8 22.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Band_3_cyto PF07565.13 CDI82887.1 - 0.49 10.1 15.5 0.63 9.8 15.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 CDI82887.1 - 0.59 8.8 22.2 0.72 8.5 22.2 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CDI82887.1 - 0.65 9.8 23.2 0.88 9.4 23.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SARAF PF06682.12 CDI82887.1 - 0.79 9.3 15.9 1 9.0 15.9 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2828 PF11443.8 CDI82887.1 - 1.3 7.0 18.5 1.6 6.8 18.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 CDI82887.1 - 1.3 9.1 15.3 1.9 8.5 15.3 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family PAT1 PF09770.9 CDI82887.1 - 1.5 7.0 37.7 1.9 6.7 37.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 CDI82887.1 - 1.6 8.8 14.3 2 8.4 14.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region N6_N4_Mtase PF01555.18 CDI82887.1 - 2 8.1 6.2 2.7 7.7 6.2 1.2 1 0 0 1 1 1 0 DNA methylase RskA PF10099.9 CDI82887.1 - 2.3 8.5 20.2 33 4.7 20.2 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA eIF-3_zeta PF05091.12 CDI82887.1 - 3 6.7 25.0 3.7 6.4 25.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FAM60A PF15396.6 CDI82887.1 - 3.5 7.6 15.0 5 7.1 15.0 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CCSAP PF15748.5 CDI82887.1 - 4.3 7.4 24.7 5.9 7.0 24.7 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SprA-related PF12118.8 CDI82887.1 - 5.5 6.0 42.6 7.3 5.6 42.6 1.1 1 0 0 1 1 1 0 SprA-related family CSG2 PF16965.5 CDI82887.1 - 5.7 5.8 10.0 6.9 5.5 10.0 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator PepSY_TM_like_2 PF16357.5 CDI82887.1 - 5.8 6.9 16.1 4.1 7.3 14.4 1.5 1 1 1 2 2 2 0 Putative PepSY_TM-like V_ATPase_I PF01496.19 CDI82887.1 - 5.9 4.7 20.4 7.2 4.4 20.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3523 PF12037.8 CDI82887.1 - 7.4 5.9 35.2 9.4 5.5 35.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) CLN3 PF02487.17 CDI82887.1 - 9.1 5.2 18.0 14 4.6 18.0 1.3 1 0 0 1 1 1 0 CLN3 protein Peptidase_S64 PF08192.11 CDI82887.1 - 9.1 4.6 19.9 13 4.1 19.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 Serinc PF03348.15 CDI82887.1 - 9.3 5.0 10.7 12 4.7 10.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4175 PF13779.6 CDI82887.1 - 9.4 4.0 50.5 11 3.7 50.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Zip PF02535.22 CDI82890.1 - 7.4e-13 48.4 12.8 4.9e-09 35.9 9.6 4.0 1 1 2 3 3 3 2 ZIP Zinc transporter Spt20 PF12090.8 CDI82890.1 - 5.4e-05 22.9 18.6 0.0042 16.7 1.1 2.3 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI82890.1 - 0.0053 17.1 21.8 0.0053 17.1 21.8 5.5 2 1 1 4 4 4 1 Anti-sigma-K factor rskA NHS PF15273.6 CDI82890.1 - 0.03 13.4 4.0 0.062 12.4 4.0 1.4 1 0 0 1 1 1 0 NHS-like DUF1360 PF07098.11 CDI82890.1 - 0.048 13.6 0.5 0.048 13.6 0.5 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1360) DUF4834 PF16118.5 CDI82890.1 - 0.19 12.7 12.0 5.1 8.1 1.8 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) PIP5K PF01504.18 CDI82890.1 - 0.21 10.8 5.0 0.024 13.9 0.7 1.5 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4207 PF13904.6 CDI82890.1 - 2.3 7.8 18.4 0.073 12.7 0.5 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) XK-related PF09815.9 CDI82890.1 - 9.4 5.2 8.8 7 5.6 0.1 2.7 2 1 1 3 3 3 0 XK-related protein Actin PF00022.19 CDI82891.1 - 3e-20 72.2 0.0 3.8e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Actin Cwf_Cwc_15 PF04889.12 CDI82892.1 - 0.035 13.9 39.8 0.055 13.2 39.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PPP4R2 PF09184.11 CDI82892.1 - 0.15 11.7 25.2 0.2 11.2 25.2 1.1 1 0 0 1 1 1 0 PPP4R2 Baculo_PP31 PF05311.11 CDI82892.1 - 0.39 10.1 17.8 0.61 9.5 17.8 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) VIR_N PF15912.5 CDI82892.1 - 0.49 10.0 10.7 0.98 9.0 10.7 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal XRN_M PF17846.1 CDI82892.1 - 0.49 9.3 15.7 0.66 8.9 15.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Myc_N PF01056.18 CDI82892.1 - 0.86 9.4 18.9 1.4 8.8 18.9 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Presenilin PF01080.17 CDI82892.1 - 0.87 8.3 25.0 1.4 7.6 25.0 1.3 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 CDI82892.1 - 1.4 7.2 15.7 1.8 6.8 15.7 1.1 1 0 0 1 1 1 0 Menin PA26 PF04636.13 CDI82892.1 - 1.5 7.6 11.1 2.3 7.1 11.1 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) eIF-3_zeta PF05091.12 CDI82892.1 - 1.9 7.4 29.3 2.7 6.9 29.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDHD PF02862.17 CDI82892.1 - 1.9 8.6 17.1 3.6 7.7 17.1 1.5 1 0 0 1 1 1 0 DDHD domain PAT1 PF09770.9 CDI82892.1 - 2.2 6.5 29.7 4 5.6 29.7 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CCSAP PF15748.5 CDI82892.1 - 3.2 7.8 27.3 6.4 6.9 27.3 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Velvet PF11754.8 CDI82892.1 - 4.8 7.1 15.2 1.7 8.5 12.7 1.6 2 0 0 2 2 1 0 Velvet factor MID_MedPIWI PF18296.1 CDI82892.1 - 4.9 6.9 23.7 8.1 6.2 23.7 1.3 1 0 0 1 1 1 0 MID domain of medPIWI PBP_sp32 PF07222.12 CDI82892.1 - 5.9 6.3 26.4 9.6 5.6 26.4 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CCDC53 PF10152.9 CDI82892.1 - 6.1 7.2 0.0 6.1 7.2 0.0 3.0 2 1 0 2 2 1 0 Subunit CCDC53 of WASH complex DUF5589 PF17672.1 CDI82892.1 - 7 6.6 6.4 1 9.3 0.4 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5589) Neur_chan_memb PF02932.16 CDI82892.1 - 7.1 6.6 14.3 14 5.6 14.3 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_L27A PF00828.19 CDI82893.1 - 1.7e-21 77.2 0.0 2.2e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Spt20 PF12090.8 CDI82895.1 - 0.006 16.2 12.8 0.006 16.2 12.8 4.1 4 0 0 4 4 4 3 Spt20 family Dehydrin PF00257.19 CDI82895.1 - 0.011 16.3 0.3 0.011 16.3 0.3 5.5 2 2 2 4 4 4 0 Dehydrin Cnd1_N PF12922.7 CDI82895.1 - 0.6 9.9 0.0 0.6 9.9 0.0 3.6 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1, N-term Spt20 PF12090.8 CDI82897.1 - 3.6 7.1 16.6 3.5 7.2 16.6 1.1 1 0 0 1 1 1 0 Spt20 family DUF2967 PF11179.8 CDI82897.1 - 7 4.6 12.5 6.2 4.8 12.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Androgen_recep PF02166.16 CDI82897.1 - 7.8 5.2 17.8 7.8 5.2 17.8 1.2 1 0 0 1 1 1 0 Androgen receptor Myosin_head PF00063.21 CDI82900.1 - 1.5e-21 76.4 3.0 1.8e-14 52.9 0.9 2.1 1 1 1 2 2 2 2 Myosin head (motor domain) ImpA_N PF06812.12 CDI82902.1 - 0.052 13.7 3.9 0.065 13.3 3.9 1.2 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system Glycolytic PF00274.19 CDI82903.1 - 1.3e-41 142.6 0.0 1.4e-41 142.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I BT1 PF03092.16 CDI82905.1 - 4.9e-18 64.6 0.8 5.8e-18 64.4 0.8 1.1 1 0 0 1 1 1 1 BT1 family DUF3458 PF11940.8 CDI82907.1 - 9.6e-10 38.8 0.0 1.2e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1 PF01433.20 CDI82907.1 - 1.5e-06 27.9 0.0 1.9e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain Pyr_redox_2 PF07992.14 CDI82910.1 - 1.6e-62 211.4 1.9 6.7e-59 199.5 1.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDI82910.1 - 5.2e-22 78.2 4.8 7.7e-19 68.0 0.4 3.0 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDI82910.1 - 5e-19 68.6 0.0 1.3e-18 67.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain FAD_oxidored PF12831.7 CDI82910.1 - 3.4e-11 43.2 2.4 2.8e-10 40.2 0.1 2.4 2 1 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 CDI82910.1 - 4.1e-10 39.3 3.1 1.6e-09 37.4 0.4 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDI82910.1 - 1.3e-06 27.8 3.7 1.3e-06 27.8 3.7 2.2 2 0 0 2 2 2 1 FAD binding domain K_oxygenase PF13434.6 CDI82910.1 - 4.5e-06 26.1 0.8 0.042 13.0 0.1 2.6 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CDI82910.1 - 7e-06 25.0 7.2 0.00043 19.1 0.2 3.8 3 1 1 4 4 4 2 HI0933-like protein Pyr_redox_3 PF13738.6 CDI82910.1 - 8.1e-06 25.3 1.3 0.14 11.3 2.4 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDI82910.1 - 2.1e-05 24.6 5.7 0.00055 20.1 1.5 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CDI82910.1 - 4.2e-05 22.9 2.2 0.031 13.6 0.1 2.6 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 CDI82910.1 - 0.00013 21.7 7.0 0.58 9.7 0.1 3.8 4 0 0 4 4 4 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDI82910.1 - 0.00016 21.0 8.9 0.12 11.6 0.7 3.1 2 1 1 3 3 3 3 FAD binding domain Thi4 PF01946.17 CDI82910.1 - 0.00018 20.9 0.6 0.00031 20.1 0.1 1.8 2 0 0 2 2 2 1 Thi4 family 2-Hacid_dh_C PF02826.19 CDI82910.1 - 0.0045 16.4 0.1 10 5.4 0.0 3.2 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDI82910.1 - 0.016 15.1 0.1 0.016 15.1 0.1 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 CDI82910.1 - 0.096 13.2 0.1 23 5.5 0.1 2.9 2 1 0 2 2 2 0 XdhC Rossmann domain Lycopene_cycl PF05834.12 CDI82910.1 - 2.7 7.0 5.3 2.9 6.8 0.9 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein Peptidase_S9_N PF02897.15 CDI82911.1 - 6.8e-107 357.8 0.1 9.5e-107 357.3 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CDI82911.1 - 6.6e-57 192.4 0.0 1.1e-56 191.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDI82911.1 - 0.031 13.9 0.3 0.64 9.6 0.0 2.6 2 1 1 3 3 3 0 alpha/beta hydrolase fold BAAT_C PF08840.11 CDI82911.1 - 0.15 11.9 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 CDI82911.1 - 0.15 11.9 0.4 0.69 9.7 0.4 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold TPR_MLP1_2 PF07926.12 CDI82915.1 - 1.8e-05 24.8 12.1 1.8e-05 24.8 12.1 6.9 2 1 2 5 5 5 1 TPR/MLP1/MLP2-like protein Pox_A_type_inc PF04508.12 CDI82915.1 - 0.046 13.6 0.5 0.046 13.6 0.5 7.3 9 0 0 9 9 9 0 Viral A-type inclusion protein repeat Minor_capsid_3 PF12691.7 CDI82915.1 - 1.1 9.7 3.3 37 4.7 0.4 2.9 2 0 0 2 2 2 0 Minor capsid protein from bacteriophage Myosin_head PF00063.21 CDI82921.1 - 1.3e-92 311.1 0.0 2.7e-92 310.1 0.0 1.4 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 CDI82921.1 - 0.021 15.1 0.3 0.13 12.6 0.2 2.2 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDI82921.1 - 0.039 13.2 0.0 0.1 11.9 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 CDI82921.1 - 0.077 12.9 0.0 0.42 10.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 CDI82921.1 - 0.091 13.1 1.6 0.37 11.1 0.1 2.7 2 1 1 3 3 3 0 AAA ATPase domain TsaE PF02367.17 CDI82921.1 - 0.12 12.3 0.1 0.38 10.8 0.1 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 CDI82921.1 - 0.24 11.1 2.7 3.5 7.3 0.2 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase tRNA-synt_2b PF00587.25 CDI82926.1 - 1.9e-07 31.3 0.0 3.6e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DDHD PF02862.17 CDI82926.1 - 0.00033 20.9 2.7 0.00044 20.5 2.7 1.4 1 0 0 1 1 1 1 DDHD domain EPL1 PF10513.9 CDI82926.1 - 0.00077 19.9 2.6 0.00077 19.9 2.6 2.0 2 0 0 2 2 2 1 Enhancer of polycomb-like Presenilin PF01080.17 CDI82926.1 - 0.00098 18.0 6.6 0.0013 17.6 6.6 1.2 1 0 0 1 1 1 1 Presenilin Eapp_C PF10238.9 CDI82926.1 - 0.0026 17.9 0.8 0.0026 17.9 0.8 2.2 2 0 0 2 2 2 1 E2F-associated phosphoprotein Suf PF05843.14 CDI82926.1 - 0.0097 15.9 12.3 0.016 15.2 12.3 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Velvet PF11754.8 CDI82926.1 - 0.01 15.8 6.6 0.014 15.4 6.6 1.2 1 0 0 1 1 1 0 Velvet factor Adaptin_binding PF10199.9 CDI82926.1 - 0.013 16.1 4.0 0.013 16.1 4.0 2.2 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Zip PF02535.22 CDI82926.1 - 0.013 14.8 0.3 0.017 14.3 0.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 CDI82926.1 - 0.036 12.8 5.8 0.04 12.6 5.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Dapper PF15268.6 CDI82926.1 - 0.047 12.6 12.9 0.063 12.1 12.9 1.1 1 0 0 1 1 1 0 Dapper MID_MedPIWI PF18296.1 CDI82926.1 - 0.053 13.3 11.2 0.08 12.7 11.2 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Neur_chan_memb PF02932.16 CDI82926.1 - 0.088 12.8 7.0 0.15 12.1 7.0 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.12 CDI82926.1 - 0.11 11.5 4.8 0.16 10.9 4.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) IMUP PF15761.5 CDI82926.1 - 0.12 13.1 10.5 0.29 11.8 10.5 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein eIF-3_zeta PF05091.12 CDI82926.1 - 0.13 11.2 10.3 0.18 10.7 10.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Baculo_PP31 PF05311.11 CDI82926.1 - 0.16 11.4 10.1 0.3 10.5 10.1 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) API5 PF05918.11 CDI82926.1 - 0.16 10.7 12.3 0.34 9.7 10.7 1.9 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) SLC12 PF03522.15 CDI82926.1 - 0.2 10.6 10.6 0.33 9.9 10.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 CDI82926.1 - 0.36 9.6 10.1 0.5 9.1 10.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4446 PF14584.6 CDI82926.1 - 0.42 10.6 6.6 6.9 6.6 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Raftlin PF15250.6 CDI82926.1 - 0.64 8.7 10.2 0.13 10.9 6.2 1.7 2 0 0 2 2 2 0 Raftlin GREB1 PF15782.5 CDI82926.1 - 0.75 6.8 12.7 0.96 6.5 12.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Activator_LAG-3 PF11498.8 CDI82926.1 - 1 8.3 25.2 1.6 7.6 25.2 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF5427 PF10310.9 CDI82926.1 - 1.1 8.1 17.1 1.8 7.4 17.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PepSY_TM PF03929.16 CDI82926.1 - 1.2 8.7 2.8 2.2 7.9 2.8 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Kei1 PF08552.11 CDI82926.1 - 1.6 8.6 5.7 2.9 7.7 5.7 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 LMBR1 PF04791.16 CDI82926.1 - 1.6 7.5 9.1 2.3 7.0 9.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Spem1 PF15670.5 CDI82926.1 - 1.7 8.2 10.3 3.2 7.3 10.3 1.4 1 0 0 1 1 1 0 Spermatid maturation protein 1 RPA43_OB PF17875.1 CDI82926.1 - 1.8 9.2 9.2 0.18 12.4 3.6 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I TERB2 PF15101.6 CDI82926.1 - 2.2 8.3 16.7 4.4 7.3 14.0 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4175 PF13779.6 CDI82926.1 - 2.4 6.0 23.7 3 5.7 23.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ACCA PF03255.14 CDI82926.1 - 3.2 7.6 12.2 2.5 7.9 3.2 2.3 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit SR-25 PF10500.9 CDI82926.1 - 3.8 7.1 20.2 0.047 13.3 12.4 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SpoIIIAH PF12685.7 CDI82926.1 - 4 7.2 19.4 0.23 11.3 7.6 2.1 2 0 0 2 2 2 0 SpoIIIAH-like protein Tim54 PF11711.8 CDI82926.1 - 5 5.8 17.2 0.15 10.8 10.4 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MCM_bind PF09739.9 CDI82926.1 - 6.4 5.1 15.3 13 4.1 15.3 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Sec62 PF03839.16 CDI82926.1 - 6.9 6.1 13.5 0.68 9.4 5.3 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 CPSF100_C PF13299.6 CDI82926.1 - 7.1 6.8 13.8 1.3 9.1 8.4 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Hid1 PF12722.7 CDI82926.1 - 7.2 4.6 13.3 13 3.8 13.3 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3292 PF11696.8 CDI82926.1 - 8.5 4.6 10.8 15 3.8 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF1764 PF08576.10 CDI82926.1 - 9.6 7.2 20.9 20 6.1 12.4 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) DAP10 PF07213.11 CDI82931.1 - 0.0012 18.8 2.7 2.3 8.3 1.2 3.7 2 0 0 2 2 2 2 DAP10 membrane protein SUIM_assoc PF16619.5 CDI82931.1 - 0.21 11.7 51.2 0.19 11.8 4.6 6.5 6 0 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI82932.1 - 0.00019 21.1 30.9 0.0039 16.8 9.8 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.12 CDI82932.1 - 0.23 11.2 22.0 0.51 10.0 3.3 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM60A PF15396.6 CDI82932.1 - 0.36 10.8 19.3 1.7 8.6 10.9 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Utp14 PF04615.13 CDI82932.1 - 1.8 7.0 26.7 2.6 6.5 26.7 1.2 1 0 0 1 1 1 0 Utp14 protein Smg8_Smg9 PF10220.9 CDI82932.1 - 2 6.6 22.1 0.8 7.9 2.3 2.1 2 0 0 2 2 2 0 Smg8_Smg9 PIEZO PF15917.5 CDI82932.1 - 2.4 7.6 19.7 0.042 13.3 10.8 2.0 2 0 0 2 2 2 0 Piezo AIF_C PF14721.6 CDI82932.1 - 2.4 8.5 14.4 0.064 13.6 3.2 2.9 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tim54 PF11711.8 CDI82932.1 - 3.1 6.5 16.4 1 8.0 9.7 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SHR-BD PF06650.12 CDI82933.1 - 5.6e-08 32.5 0.0 5e-06 26.1 0.0 3.8 4 0 0 4 4 4 1 SHR-binding domain of vacuolar-sorting associated protein 13 rve PF00665.26 CDI82936.1 - 5.4e-16 58.9 0.0 1.2e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CDI82936.1 - 3e-14 52.7 0.1 5.7e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SecM PF06558.12 CDI82936.1 - 0.12 12.4 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) PKS_DE PF18369.1 CDI82936.1 - 0.73 10.4 4.9 29 5.3 3.5 2.6 2 0 0 2 2 2 0 Polyketide synthase dimerisation element domain PDEase_I PF00233.19 CDI82937.1 - 1.9e-22 80.2 0.0 2.5e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Pkinase PF00069.25 CDI82938.1 - 9.4e-42 143.2 0.0 4.5e-24 85.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain EF-hand_1 PF00036.32 CDI82938.1 - 2.2e-24 83.2 0.0 1.7e-06 27.1 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDI82938.1 - 1.5e-23 83.0 0.0 2.3e-10 40.7 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI82938.1 - 1.3e-19 68.3 0.0 0.0001 21.9 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDI82938.1 - 5.1e-18 64.7 3.2 2.5e-05 24.0 0.1 4.7 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 CDI82938.1 - 3.7e-17 61.0 0.3 2.2e-06 26.9 0.0 3.7 3 0 0 3 3 3 3 EF hand Pkinase_Tyr PF07714.17 CDI82938.1 - 8.3e-17 61.3 0.0 2.7e-12 46.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase CBM_20 PF00686.19 CDI82938.1 - 1.2e-13 50.8 0.0 2.4e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Starch binding domain SPARC_Ca_bdg PF10591.9 CDI82938.1 - 2.9e-07 30.8 0.0 0.00034 20.9 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDI82938.1 - 3.4e-06 27.0 0.0 0.0038 17.2 0.0 2.5 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CDI82938.1 - 0.013 15.8 0.0 2.1 8.7 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 CDI82938.1 - 0.02 15.1 0.3 0.16 12.2 0.3 2.3 1 1 0 1 1 1 0 Dockerin type I domain Smg4_UPF3 PF03467.15 CDI82938.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Smg-4/UPF3 family DUF1194 PF06707.11 CDI82938.1 - 0.16 11.1 0.0 0.33 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) Atx10homo_assoc PF09759.9 CDI82939.1 - 0.00062 19.7 0.0 0.0041 17.1 0.0 2.4 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain SID-1_RNA_chan PF13965.6 CDI82939.1 - 2.5 6.4 6.0 4.3 5.6 3.7 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 AAA_33 PF13671.6 CDI82941.1 - 3.9e-05 23.9 2.0 0.008 16.3 0.5 2.9 2 1 0 2 2 2 2 AAA domain KTI12 PF08433.10 CDI82941.1 - 4e-05 23.2 0.5 0.039 13.4 0.1 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_22 PF13401.6 CDI82941.1 - 0.00036 20.8 0.0 0.17 12.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDI82941.1 - 0.00086 19.7 3.2 0.0016 18.9 0.1 2.7 3 0 0 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.21 CDI82941.1 - 0.0012 18.2 0.1 0.0034 16.8 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CDI82941.1 - 0.018 15.6 0.0 0.032 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDI82941.1 - 0.032 14.6 0.0 0.12 12.8 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDI82941.1 - 0.084 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Apt1 PF10351.9 CDI82941.1 - 4.7 6.0 28.7 0.43 9.4 12.5 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 CDI82941.1 - 6.4 5.4 11.1 1.9 7.2 3.4 2.3 2 0 0 2 2 2 0 Presenilin SPT6_acidic PF14632.6 CDI82942.1 - 1.8e-08 34.8 7.8 1.8e-08 34.8 7.8 7.6 6 2 1 7 7 7 2 Acidic N-terminal SPT6 SH2_2 PF14633.6 CDI82942.1 - 4.2e-07 29.6 0.0 4.2e-07 29.6 0.0 4.2 5 1 0 5 5 5 1 SH2 domain HTH_44 PF14641.6 CDI82942.1 - 0.00048 20.5 0.7 0.0022 18.4 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 CDI82942.1 - 0.0053 17.1 0.0 0.018 15.4 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif IMUP PF15761.5 CDI82942.1 - 0.0089 16.7 4.9 0.0089 16.7 4.9 13.5 10 3 2 12 12 12 1 Immortalisation up-regulated protein YqgF PF14639.6 CDI82942.1 - 0.053 13.3 0.0 0.92 9.3 0.0 2.8 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 HHV6-IE PF03753.13 CDI82942.1 - 0.75 7.2 13.0 1.1 6.6 13.0 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein DegS PF05384.11 CDI82943.1 - 0.0051 16.3 0.4 0.0084 15.6 0.4 1.4 1 0 0 1 1 1 1 Sensor protein DegS WbqC PF08889.11 CDI82943.1 - 0.11 12.4 0.9 0.13 12.2 0.9 1.1 1 0 0 1 1 1 0 WbqC-like protein family DRY_EERY PF09750.9 CDI82943.1 - 0.19 12.0 3.2 0.31 11.3 3.2 1.4 1 1 0 1 1 1 0 Alternative splicing regulator TcdA_TcdB_pore PF12920.7 CDI82943.1 - 0.44 8.7 4.8 0.44 8.7 4.8 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain Kelch_4 PF13418.6 CDI82945.1 - 0.0018 18.2 0.1 0.006 16.6 0.1 1.9 1 1 0 1 1 1 1 Galactose oxidase, central domain FeoA PF04023.14 CDI82945.1 - 0.069 13.4 0.2 1.2 9.4 0.1 2.5 2 0 0 2 2 2 0 FeoA domain PAM2 PF07145.15 CDI82945.1 - 0.08 12.7 0.6 0.16 11.7 0.6 1.5 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Kelch_6 PF13964.6 CDI82945.1 - 0.08 13.3 0.0 0.26 11.6 0.0 1.9 1 0 0 1 1 1 0 Kelch motif RNA_pol_Rpb1_5 PF04998.17 CDI82946.1 - 9.7e-101 336.7 0.2 1.4e-100 336.2 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 CDI82946.1 - 2.7e-95 319.3 0.0 4.6e-95 318.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CDI82946.1 - 1.4e-74 249.8 0.0 2.7e-74 248.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 CDI82946.1 - 2.7e-48 164.4 3.4 4.9e-48 163.5 3.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 CDI82946.1 - 9.9e-47 158.3 0.8 9.9e-47 158.3 0.8 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 CDI82946.1 - 4.3e-44 150.2 0.0 1.5e-43 148.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CDI82946.1 - 2.2e-39 133.7 0.2 5.3e-39 132.5 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 CDI82946.1 - 0.024 15.0 221.1 0.021 15.2 14.0 16.9 13 3 3 16 16 16 0 RNA polymerase Rpb1 C-terminal repeat LSM PF01423.22 CDI82947.1 - 5.1e-16 58.1 0.4 6.3e-16 57.8 0.4 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDI82947.1 - 0.038 13.6 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Hfq protein SM-ATX PF14438.6 CDI82947.1 - 0.063 13.4 0.0 0.075 13.2 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain RCC1 PF00415.18 CDI82948.1 - 9.8e-12 45.3 0.1 7.5e-07 29.7 0.1 3.3 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI82948.1 - 7.7e-08 31.9 4.1 2.4e-05 24.0 0.4 3.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Cytochrom_C PF00034.21 CDI82950.1 - 9.9e-12 45.9 0.0 1.4e-11 45.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDI82950.1 - 1.4e-06 28.6 2.0 3.8e-06 27.1 2.0 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CDI82950.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.5 2 0 0 2 2 2 1 Cytochrome c-550 domain Haem_bd PF14376.6 CDI82950.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Haem-binding domain GIDA PF01134.22 CDI82951.1 - 5.6e-99 331.9 18.2 1.1e-53 182.8 0.0 4.6 3 1 1 4 4 4 3 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDI82951.1 - 3.7e-09 37.1 0.1 3.7e-09 37.1 0.1 5.3 4 1 0 4 4 4 1 GidA associated domain YL1 PF05764.13 CDI82951.1 - 0.00016 21.9 4.0 0.00016 21.9 4.0 5.1 5 0 0 5 5 5 1 YL1 nuclear protein Pyr_redox_2 PF07992.14 CDI82951.1 - 0.0032 16.7 0.1 0.0032 16.7 0.1 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDI82951.1 - 0.065 13.8 1.0 0.26 11.9 1.0 2.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Acetyltransf_1 PF00583.25 CDI82952.1 - 1.2e-05 25.5 0.0 3.3e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDI82952.1 - 0.0018 18.7 0.0 0.0062 16.9 0.0 2.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain BRX_assoc PF16627.5 CDI82952.1 - 0.11 12.6 0.9 0.34 11.1 0.9 1.8 1 0 0 1 1 1 0 Unstructured region between BRX_N and BRX domain GREB1 PF15782.5 CDI82952.1 - 2.5 5.1 14.8 0.037 11.2 0.7 2.1 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer SAPS PF04499.15 CDI82952.1 - 6.4 5.4 13.6 21 3.7 13.6 1.7 1 1 0 1 1 1 0 SIT4 phosphatase-associated protein WD40 PF00400.32 CDI82953.1 - 7.6e-09 36.1 0.1 0.0039 18.0 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat RskA PF10099.9 CDI82953.1 - 0.014 15.7 7.6 0.025 14.9 4.1 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF2681 PF10883.8 CDI82953.1 - 8.3 6.9 11.5 13 6.2 6.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) ATG27 PF09451.10 CDI82954.1 - 7.6 6.3 9.6 0.085 12.7 0.6 2.1 1 1 1 2 2 2 0 Autophagy-related protein 27 Presenilin PF01080.17 CDI82955.1 - 0.001 17.9 4.4 0.001 17.9 4.4 1.2 1 0 0 1 1 1 1 Presenilin DUF702 PF05142.12 CDI82955.1 - 0.0012 19.3 1.9 0.0012 19.3 1.9 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF702) Spt20 PF12090.8 CDI82955.1 - 0.0027 17.4 18.2 0.0027 17.4 18.2 1.4 2 0 0 2 2 1 1 Spt20 family Apt1 PF10351.9 CDI82955.1 - 0.0035 16.3 7.0 0.0037 16.2 7.0 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain NPR3 PF03666.13 CDI82955.1 - 0.0054 15.6 6.1 0.0055 15.5 6.1 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 CDI82955.1 - 0.0073 14.9 11.1 0.0087 14.7 11.1 1.2 1 0 0 1 1 1 1 Macoilin family DUF913 PF06025.12 CDI82955.1 - 0.0079 15.2 2.5 0.011 14.7 2.5 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Androgen_recep PF02166.16 CDI82955.1 - 0.011 14.6 7.7 0.012 14.5 7.7 1.2 1 0 0 1 1 1 0 Androgen receptor Zip PF02535.22 CDI82955.1 - 0.012 14.8 3.6 0.014 14.6 3.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Tim54 PF11711.8 CDI82955.1 - 0.024 13.4 0.5 0.028 13.2 0.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Menin PF05053.13 CDI82955.1 - 0.032 12.6 6.1 0.032 12.6 6.1 1.1 1 0 0 1 1 1 0 Menin MPM1 PF17234.2 CDI82955.1 - 0.045 14.0 10.5 0.081 13.2 10.5 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SLC12 PF03522.15 CDI82955.1 - 0.053 12.6 6.1 0.063 12.3 6.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 CDI82955.1 - 0.089 12.4 5.5 0.16 11.6 5.5 1.4 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 CDI82955.1 - 0.095 12.5 2.7 0.14 11.9 2.7 1.2 1 0 0 1 1 1 0 Connexin CLN3 PF02487.17 CDI82955.1 - 0.13 11.3 3.6 0.18 10.8 3.6 1.2 1 0 0 1 1 1 0 CLN3 protein Sporozoite_P67 PF05642.11 CDI82955.1 - 0.28 9.2 10.5 0.34 8.9 10.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Afi1 PF07792.12 CDI82955.1 - 0.31 11.5 7.9 0.12 12.8 5.7 1.4 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RAP1 PF07218.11 CDI82955.1 - 0.37 9.0 8.7 0.41 8.9 8.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Mem_trans PF03547.18 CDI82955.1 - 0.43 8.9 3.3 0.57 8.5 3.3 1.1 1 0 0 1 1 1 0 Membrane transport protein OATP PF03137.20 CDI82955.1 - 0.47 8.7 4.8 0.64 8.2 4.8 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Otopetrin PF03189.13 CDI82955.1 - 0.53 9.0 3.7 0.61 8.8 3.7 1.1 1 0 0 1 1 1 0 Otopetrin SpoIIIAH PF12685.7 CDI82955.1 - 0.61 9.9 15.8 0.19 11.6 9.3 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein Ndc1_Nup PF09531.10 CDI82955.1 - 0.65 8.6 8.2 0.71 8.5 8.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup V_ATPase_I PF01496.19 CDI82955.1 - 1.4 6.7 8.9 2 6.2 8.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SID-1_RNA_chan PF13965.6 CDI82955.1 - 2.1 6.6 6.1 2.9 6.2 6.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Kei1 PF08552.11 CDI82955.1 - 3.2 7.6 4.8 5.7 6.8 4.8 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF1635 PF07795.11 CDI82955.1 - 3.8 7.3 19.2 1.3 8.9 15.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DivIC PF04977.15 CDI82955.1 - 4.1 7.2 10.4 2.2 8.1 4.9 2.2 2 0 0 2 2 2 0 Septum formation initiator Ctr PF04145.15 CDI82955.1 - 4.4 7.9 9.9 5.7 7.6 9.9 1.4 1 1 0 1 1 1 0 Ctr copper transporter family PNISR PF15996.5 CDI82955.1 - 4.7 7.4 20.2 0.64 10.3 14.2 1.9 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR NST1 PF13945.6 CDI82955.1 - 4.9 7.2 23.7 0.64 10.1 19.9 1.4 2 0 0 2 2 1 0 Salt tolerance down-regulator DUF908 PF06012.12 CDI82955.1 - 5.4 6.3 18.1 6.9 6.0 17.8 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) ALMT PF11744.8 CDI82955.1 - 8.9 5.0 11.3 0.89 8.3 6.5 1.6 2 0 0 2 2 2 0 Aluminium activated malate transporter RILP PF11461.8 CDI82963.1 - 0.00018 21.6 1.1 0.048 13.9 0.0 3.5 3 0 0 3 3 3 1 Rab interacting lysosomal protein DUF2046 PF09755.9 CDI82963.1 - 0.00029 20.2 10.1 0.028 13.6 1.7 3.1 2 1 0 3 3 3 2 Uncharacterized conserved protein H4 (DUF2046) CCDC-167 PF15188.6 CDI82963.1 - 0.0019 18.5 18.6 0.56 10.6 0.9 4.1 4 0 0 4 4 4 2 Coiled-coil domain-containing protein 167 DUF2353 PF09789.9 CDI82963.1 - 0.0039 16.6 3.2 0.0039 16.6 3.2 2.8 2 1 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Fez1 PF06818.15 CDI82963.1 - 0.013 15.9 11.4 0.33 11.4 8.5 2.4 1 1 1 2 2 2 0 Fez1 FlxA PF14282.6 CDI82963.1 - 0.024 14.6 6.8 4.7 7.3 0.5 4.3 4 0 0 4 4 4 0 FlxA-like protein Lzipper-MIP1 PF14389.6 CDI82963.1 - 0.035 14.4 17.5 3.6 8.0 0.1 4.3 3 1 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Uds1 PF15456.6 CDI82963.1 - 0.066 13.4 16.3 0.32 11.2 2.5 3.5 2 1 0 2 2 2 0 Up-regulated During Septation YabA PF06156.13 CDI82963.1 - 0.067 13.8 12.9 0.5 11.0 1.0 3.8 2 2 0 3 3 3 0 Initiation control protein YabA Rho_Binding PF08912.11 CDI82963.1 - 0.085 13.7 0.1 0.085 13.7 0.1 4.3 4 1 0 4 4 4 0 Rho Binding ATG16 PF08614.11 CDI82963.1 - 0.091 13.0 35.5 0.062 13.5 3.9 5.2 4 1 1 5 5 4 0 Autophagy protein 16 (ATG16) TSC22 PF01166.18 CDI82963.1 - 0.27 11.6 14.8 19 5.7 0.0 4.9 4 1 1 5 5 5 0 TSC-22/dip/bun family AIP3 PF03915.13 CDI82963.1 - 0.56 9.2 10.3 95 1.9 10.2 2.8 1 1 0 1 1 1 0 Actin interacting protein 3 IFP_35_N PF07334.13 CDI82963.1 - 0.94 9.6 7.9 8.4 6.6 0.1 3.5 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus PRKG1_interact PF15898.5 CDI82963.1 - 1.1 10.2 21.4 0.11 13.4 1.4 4.3 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain Ribosomal_L29 PF00831.23 CDI82963.1 - 1.1 9.3 21.2 0.3 11.1 0.2 4.7 4 1 0 4 4 4 0 Ribosomal L29 protein TMF_TATA_bd PF12325.8 CDI82963.1 - 1.2 9.3 21.4 5.2 7.3 4.3 4.1 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding PilJ PF13675.6 CDI82963.1 - 2.3 8.3 18.4 7.4 6.6 0.1 5.1 4 1 0 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term HALZ PF02183.18 CDI82963.1 - 2.9 8.2 29.9 0.067 13.4 2.1 5.5 5 1 1 6 6 6 0 Homeobox associated leucine zipper LRRFIP PF09738.9 CDI82963.1 - 3.1 7.2 16.2 0.13 11.7 0.3 3.0 2 1 0 2 2 1 0 LRRFIP family LURAP PF14854.6 CDI82963.1 - 3.1 7.8 4.8 35 4.4 0.2 3.2 3 0 0 3 3 3 0 Leucine rich adaptor protein TMCO5 PF14992.6 CDI82963.1 - 3.5 7.1 9.2 7.5 6.0 3.5 2.4 2 1 0 2 2 2 0 TMCO5 family Phage_GP20 PF06810.11 CDI82963.1 - 3.8 7.3 16.0 0.63 9.8 1.3 4.0 4 0 0 4 4 4 0 Phage minor structural protein GP20 DUF4407 PF14362.6 CDI82963.1 - 3.9 6.8 23.8 0.11 11.9 3.7 3.1 2 1 1 4 4 4 0 Domain of unknown function (DUF4407) SlyX PF04102.12 CDI82963.1 - 4 8.1 18.7 15 6.3 0.2 4.8 4 1 0 4 4 4 0 SlyX JIP_LZII PF16471.5 CDI82963.1 - 4.1 7.7 23.6 1.7 8.9 1.6 4.8 4 2 1 5 5 4 0 JNK-interacting protein leucine zipper II Prefoldin_2 PF01920.20 CDI82963.1 - 4.5 7.3 21.7 0.66 10.0 2.3 3.8 3 1 0 3 3 3 0 Prefoldin subunit Flg_hook PF02120.16 CDI82963.1 - 4.6 7.2 9.1 0.67 9.9 0.7 3.3 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK DivIC PF04977.15 CDI82963.1 - 5 7.0 25.0 1.7 8.5 3.7 4.5 4 1 0 4 4 4 0 Septum formation initiator Prefoldin PF02996.17 CDI82963.1 - 5 7.1 15.6 3.7 7.5 2.5 4.1 4 0 0 4 4 4 0 Prefoldin subunit GAS PF13851.6 CDI82963.1 - 5.1 6.4 25.5 1.3 8.3 2.0 4.0 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding Macoilin PF09726.9 CDI82963.1 - 5.5 5.4 10.4 1.1 7.7 0.1 2.9 3 0 0 3 3 3 0 Macoilin family HU-CCDC81_bac_2 PF18175.1 CDI82963.1 - 6.4 6.7 9.3 0.4 10.6 0.6 3.0 3 1 0 3 3 2 0 CCDC81-like prokaryotic HU domain 2 HOOK PF05622.12 CDI82963.1 - 6.9 4.7 17.0 13 3.8 8.5 3.4 3 1 0 3 3 3 0 HOOK protein TPD52 PF04201.15 CDI82963.1 - 7.1 6.2 14.8 4 7.0 0.0 4.2 4 0 0 4 4 4 0 Tumour protein D52 family Tropomyosin_1 PF12718.7 CDI82963.1 - 8.5 6.5 23.1 17 5.6 5.6 4.2 4 0 0 4 4 4 0 Tropomyosin like Rab5-bind PF09311.11 CDI82963.1 - 8.7 5.6 13.9 0.91 8.9 0.6 2.8 3 1 0 3 3 2 0 Rabaptin-like protein Chibby PF14645.6 CDI82963.1 - 9.1 6.7 7.3 11 6.4 0.9 3.6 4 1 0 4 4 4 0 Chibby family AAA_23 PF13476.6 CDI82963.1 - 9.1 6.7 6.7 2.5 8.6 2.1 2.0 2 0 0 2 2 2 0 AAA domain bZIP_Maf PF03131.17 CDI82963.1 - 9.9 6.8 19.7 10 6.7 0.1 4.4 4 1 0 4 4 4 0 bZIP Maf transcription factor DUF3273 PF11677.8 CDI82964.1 - 2e-19 69.9 0.5 2.2e-19 69.8 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) DUF2568 PF10823.8 CDI82964.1 - 0.0062 16.8 0.3 0.0085 16.3 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2568) RNA_POL_M_15KD PF02150.16 CDI82966.1 - 3.6e-07 29.9 6.1 3.6e-07 29.9 6.1 2.8 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 CDI82966.1 - 3.8e-07 29.9 0.5 3.8e-07 29.9 0.5 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) zf-ribbon_3 PF13248.6 CDI82966.1 - 0.038 13.4 3.5 3.8 7.1 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Nudc_N PF14050.6 CDI82966.1 - 0.086 12.8 0.2 0.27 11.3 0.2 1.8 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. zinc_ribbon_9 PF14369.6 CDI82966.1 - 0.16 12.3 1.8 2.5 8.4 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon IBR PF01485.21 CDI82966.1 - 0.26 11.6 6.8 1.4 9.2 0.6 3.0 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain zf-IS66 PF13005.7 CDI82966.1 - 0.32 11.4 5.8 1.4 9.4 0.2 3.1 2 1 0 2 2 2 0 zinc-finger binding domain of transposase IS66 zinc_ribbon_10 PF10058.9 CDI82966.1 - 0.49 10.2 4.0 12 5.7 0.5 3.0 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein CpXC PF14353.6 CDI82966.1 - 0.69 10.0 0.0 0.69 10.0 0.0 2.4 2 1 1 3 3 3 0 CpXC protein PHD PF00628.29 CDI82966.1 - 1.1 9.2 8.1 8 6.4 2.7 3.1 3 1 0 3 3 3 0 PHD-finger zf-RRN7 PF11781.8 CDI82966.1 - 1.6 8.4 7.6 18 5.1 0.8 3.4 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-ACC PF17848.1 CDI82966.1 - 2.4 8.3 7.3 12 6.1 0.2 3.7 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Zn_ribbon_recom PF13408.6 CDI82966.1 - 6.4 7.4 7.1 0.63 10.6 0.6 2.3 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.7 CDI82966.1 - 7.4 6.6 7.8 19 5.3 1.0 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 CDI82966.1 - 9.6 5.8 10.5 20 4.8 0.7 3.1 2 1 0 2 2 2 0 TFIIB zinc-binding TFB6 PF17110.5 CDI82969.1 - 3.6 7.3 12.6 11 5.7 0.1 3.7 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH TRAUB PF08164.12 CDI82970.1 - 2.6e-11 43.8 0.0 2.6e-11 43.8 0.0 3.8 2 1 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 CDI82970.1 - 3.7e-05 24.4 8.3 3.7e-05 24.4 8.3 2.4 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor DUF4667 PF15700.5 CDI82970.1 - 0.083 13.0 7.9 0.12 12.4 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) IMUP PF15761.5 CDI82970.1 - 0.38 11.5 13.3 0.37 11.5 7.0 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein AbiH PF14253.6 CDI82971.1 - 0.67 9.8 4.4 0.65 9.8 0.4 2.2 2 0 0 2 2 2 0 Bacteriophage abortive infection AbiH GrpE PF01025.19 CDI82972.1 - 7.3e-40 136.4 16.9 2.1e-39 134.9 16.9 1.9 1 1 0 1 1 1 1 GrpE DUF1664 PF07889.12 CDI82972.1 - 0.0025 17.9 2.6 0.0025 17.9 2.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) ZapB PF06005.12 CDI82972.1 - 0.076 13.5 25.8 0.1 13.1 6.7 2.5 2 0 0 2 2 2 0 Cell division protein ZapB EF-hand_14 PF17959.1 CDI82972.1 - 0.15 12.4 2.7 0.5 10.7 2.8 1.9 1 1 1 2 2 2 0 EF-hand domain Laminin_II PF06009.12 CDI82972.1 - 0.5 10.4 16.5 0.35 10.9 13.9 1.9 1 1 1 2 2 2 0 Laminin Domain II USP8_interact PF08941.10 CDI82972.1 - 1.5 8.6 8.5 1.5 8.6 5.4 2.0 2 0 0 2 2 2 0 USP8 interacting YjbH PF06082.11 CDI82972.1 - 1.6 7.5 8.6 2 7.1 8.6 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DDE_Tnp_IS240 PF13610.6 CDI82972.1 - 1.6 8.9 4.8 2.9 8.1 2.3 2.0 1 1 1 2 2 2 0 DDE domain Mod_r PF07200.13 CDI82972.1 - 1.7 8.7 29.7 5.7 7.0 15.2 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FlgN PF05130.12 CDI82972.1 - 3.7 8.0 28.1 4.9 7.6 5.7 2.4 1 1 1 2 2 2 0 FlgN protein OTCace_N PF02729.21 CDI82972.1 - 4.4 7.3 8.3 23 5.0 6.2 2.5 1 1 1 2 2 2 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain YabA PF06156.13 CDI82972.1 - 4.6 7.9 17.7 1.1e+03 0.3 17.7 2.3 1 1 0 1 1 1 0 Initiation control protein YabA Cauli_AT PF03233.13 CDI82972.1 - 4.7 7.1 6.1 5.8 6.8 0.5 2.2 2 0 0 2 2 2 0 Aphid transmission protein Rho_Binding PF08912.11 CDI82972.1 - 9 7.2 21.0 1.4 9.8 8.2 2.7 2 1 1 3 3 3 0 Rho Binding STAG PF08514.11 CDI82972.1 - 9.1 6.2 11.0 30 4.6 10.9 2.0 1 1 0 1 1 1 0 STAG domain DUF4404 PF14357.6 CDI82972.1 - 9.9 6.9 18.3 9.3 7.0 4.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Macin PF14865.6 CDI82973.1 - 0.0023 18.4 0.4 3.4 8.3 0.0 2.2 2 0 0 2 2 2 2 Macin SIP PF04954.13 CDI82973.1 - 0.012 16.1 0.0 0.017 15.6 0.0 1.4 1 1 0 1 1 1 0 Siderophore-interacting protein LAS2 PF15792.5 CDI82973.1 - 0.06 13.9 0.0 18 5.9 0.0 2.1 2 0 0 2 2 2 0 Lung adenoma susceptibility protein 2 ChapFlgA_N PF17656.1 CDI82973.1 - 0.061 13.5 0.7 2.3 8.5 0.1 2.4 2 1 0 2 2 2 0 FlgA N-terminal domain Synthase_beta PF11421.8 CDI82973.1 - 8.9 7.1 8.8 20 6.0 0.3 2.8 3 0 0 3 3 3 0 ATP synthase F1 beta subunit Ubie_methyltran PF01209.18 CDI82978.1 - 1.2e-62 211.4 0.0 2.2e-44 151.5 0.0 3.3 3 1 0 3 3 3 3 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CDI82978.1 - 4.6e-14 52.9 0.1 1.2e-06 29.1 0.0 3.3 2 1 1 3 3 3 3 Methyltransferase domain Methyltransf_11 PF08241.12 CDI82978.1 - 1.9e-13 50.9 0.1 3.4e-10 40.4 0.0 3.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI82978.1 - 8.5e-10 38.7 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDI82978.1 - 5.3e-08 33.5 0.0 7.7e-06 26.6 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI82978.1 - 3.1e-06 27.1 2.7 0.027 14.3 0.0 3.6 2 1 1 3 3 3 1 Methyltransferase domain Med15 PF09606.10 CDI82978.1 - 0.00066 18.5 24.8 0.00086 18.1 24.8 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2722 PF10846.8 CDI82978.1 - 0.00096 18.2 14.8 0.0012 17.8 14.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF3512 PF12024.8 CDI82978.1 - 0.0062 16.0 0.4 0.0098 15.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) TFIIA PF03153.13 CDI82978.1 - 0.0099 15.9 15.0 0.012 15.6 15.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit FHIPEP PF00771.20 CDI82978.1 - 0.031 12.7 0.6 0.04 12.4 0.6 1.1 1 0 0 1 1 1 0 FHIPEP family eIF-3_zeta PF05091.12 CDI82978.1 - 0.041 12.9 4.2 0.052 12.5 4.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GREB1 PF15782.5 CDI82978.1 - 0.12 9.4 2.1 0.16 9.1 2.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4746 PF15928.5 CDI82978.1 - 0.14 11.5 1.2 19 4.5 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 CDI82978.1 - 0.14 10.9 1.8 0.22 10.2 1.8 1.3 1 0 0 1 1 1 0 Presenilin RskA PF10099.9 CDI82978.1 - 0.15 12.3 8.9 0.22 11.8 8.9 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4175 PF13779.6 CDI82978.1 - 0.2 9.5 15.9 0.27 9.1 15.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Activator_LAG-3 PF11498.8 CDI82978.1 - 0.21 10.5 24.4 0.29 10.0 24.4 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Suf PF05843.14 CDI82978.1 - 0.36 10.8 5.9 0.51 10.3 5.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UNC-79 PF14776.6 CDI82978.1 - 0.38 9.4 3.4 0.59 8.8 3.4 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 RED_N PF07808.13 CDI82978.1 - 0.58 9.7 7.8 0.84 9.2 7.8 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF4834 PF16118.5 CDI82978.1 - 2.8 9.0 8.6 5.1 8.1 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 CDI82978.1 - 2.9 7.9 9.5 4.4 7.3 9.5 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Spt20 PF12090.8 CDI82978.1 - 4.4 6.9 28.0 6.7 6.3 28.0 1.2 1 0 0 1 1 1 0 Spt20 family FlaG PF03646.15 CDI82978.1 - 4.5 7.5 14.0 8.3 6.6 14.0 1.4 1 0 0 1 1 1 0 FlaG protein UPF0560 PF10577.9 CDI82978.1 - 9.3 4.6 12.4 13 4.2 12.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 C2 PF00168.30 CDI82979.1 - 0.013 15.8 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 C2 domain SIS PF01380.22 CDI82980.1 - 3.2e-35 120.8 0.6 8e-19 67.8 0.0 3.0 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 CDI82980.1 - 8.7e-20 71.3 0.0 1.8e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDI82980.1 - 4.1e-16 59.0 0.0 7.7e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CDI82980.1 - 2e-05 23.7 0.1 4.2e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferases class-II LRR_4 PF12799.7 CDI82981.1 - 5.3e-13 48.9 15.0 0.00029 21.2 0.2 3.9 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI82981.1 - 1.2e-06 28.1 12.0 0.0042 16.8 1.6 3.8 2 2 1 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 CDI82981.1 - 9.6e-06 25.2 1.1 6.5e-05 22.5 0.4 2.1 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.33 CDI82981.1 - 9.9e-06 25.4 11.4 4.3 8.3 0.0 6.2 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 CDI82981.1 - 1.1e-05 25.1 9.4 1 9.6 0.1 5.7 5 0 0 5 5 5 2 Leucine Rich repeat FCD PF07729.12 CDI82981.1 - 0.1 13.0 0.1 0.24 11.8 0.1 1.5 1 0 0 1 1 1 0 FCD domain Kelch_1 PF01344.25 CDI82985.1 - 4.7e-06 26.1 0.1 8.1e-06 25.3 0.1 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_5 PF13854.6 CDI82985.1 - 1.2e-05 25.2 1.1 4.3e-05 23.4 0.1 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 CDI82985.1 - 1.5e-05 25.1 0.1 0.00016 21.9 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 CDI82985.1 - 0.017 15.1 0.1 0.082 12.9 0.0 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI82985.1 - 0.017 15.0 0.2 0.028 14.4 0.2 1.3 1 0 0 1 1 1 0 Kelch motif TrbI PF03743.14 CDI82987.1 - 0.14 11.9 0.8 0.18 11.7 0.8 1.1 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein DUF2722 PF10846.8 CDI82994.1 - 0.26 10.2 22.3 0.05 12.5 5.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI82994.1 - 1.2 8.7 22.4 0.068 12.8 9.5 2.4 2 0 0 2 2 2 0 Spt20 family CDC45 PF02724.14 CDI82994.1 - 4.4 5.5 12.1 2.9 6.1 9.2 1.8 2 0 0 2 2 2 0 CDC45-like protein SpoIIIAH PF12685.7 CDI82994.1 - 4.9 6.9 21.0 2.2 8.1 13.5 2.5 2 0 0 2 2 2 0 SpoIIIAH-like protein ORC_WH_C PF18137.1 CDI82994.1 - 8.7 6.4 8.1 44 4.1 4.1 2.9 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal PrsW-protease PF13367.6 CDI82995.1 - 1.2e-12 47.7 9.9 1.2e-10 41.2 3.9 4.1 4 0 0 4 4 4 2 PrsW family intramembrane metalloprotease TFIIA PF03153.13 CDI82995.1 - 0.17 11.8 50.0 0.052 13.5 20.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF5533 PF17685.1 CDI82995.1 - 0.88 10.0 3.8 0.75 10.2 0.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5533) Ribosomal_L28e PF01778.17 CDI82996.1 - 6.5e-31 107.5 4.0 6.5e-31 107.5 4.0 2.7 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.14 CDI82996.1 - 1.1e-15 58.1 25.8 3.9e-14 53.1 25.8 2.9 1 1 0 1 1 1 1 Mak16 protein C-terminal region Ribosomal_L18 PF17135.4 CDI82997.1 - 6.3e-85 283.3 1.3 7e-85 283.1 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 CDI82997.1 - 0.00068 20.3 0.0 0.0012 19.5 0.0 1.5 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AP2 PF00847.20 CDI82998.1 - 0.057 13.7 0.1 0.057 13.7 0.1 2.6 2 1 1 3 3 3 0 AP2 domain DUF572 PF04502.13 CDI82998.1 - 0.33 10.5 19.1 0.6 9.7 19.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Band_3_cyto PF07565.13 CDI82998.1 - 0.7 9.6 21.8 0.94 9.2 5.5 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain AbLIM_anchor PF16182.5 CDI82998.1 - 2.2 8.0 24.4 3 7.6 23.9 1.5 1 1 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM CPSF100_C PF13299.6 CDI82998.1 - 6.4 6.9 18.3 7.9 6.6 3.2 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 CDI82998.1 - 8 5.8 23.2 4 6.8 6.7 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) EOS1 PF12326.8 CDI82998.1 - 8.5 6.3 11.2 0.87 9.5 0.5 2.3 2 0 0 2 2 2 0 N-glycosylation protein HCO3_cotransp PF00955.21 CDI82998.1 - 8.8 5.0 13.5 0.33 9.7 1.3 2.0 2 0 0 2 2 2 0 HCO3- transporter family Fibrillarin PF01269.17 CDI82999.1 - 8.9e-106 352.1 0.0 1.1e-105 351.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CDI82999.1 - 0.00056 19.7 0.0 0.00083 19.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 CDI82999.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 CDI82999.1 - 0.2 10.7 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase SopA_C PF13979.6 CDI83004.1 - 0.13 12.0 0.2 0.56 9.9 0.1 2.0 1 1 1 2 2 2 0 SopA-like catalytic domain AAA_16 PF13191.6 CDI83006.1 - 1.6e-05 25.3 0.6 1.6e-05 25.3 0.6 3.2 4 0 0 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 CDI83006.1 - 0.006 16.3 0.1 0.015 15.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CDI83006.1 - 0.02 14.2 0.0 0.085 12.1 0.1 2.0 2 0 0 2 2 2 0 Zeta toxin ABC_tran PF00005.27 CDI83006.1 - 0.039 14.5 0.2 0.099 13.2 0.2 1.6 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 CDI83006.1 - 0.15 12.5 0.1 0.33 11.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDI83006.1 - 0.16 12.0 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDI83006.1 - 0.21 12.2 0.0 2.3 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDI83006.1 - 0.28 11.3 5.9 0.37 10.9 0.2 3.3 3 1 0 3 3 3 0 AAA domain Macoilin PF09726.9 CDI83006.1 - 0.75 8.3 27.1 0.066 11.8 8.9 3.2 3 0 0 3 3 3 0 Macoilin family Bromodomain PF00439.25 CDI83007.1 - 0.00041 20.4 0.0 0.00065 19.7 0.0 1.3 1 0 0 1 1 1 1 Bromodomain SR-25 PF10500.9 CDI83007.1 - 4.5 6.8 11.5 0.51 9.9 4.8 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DEAD PF00270.29 CDI83008.1 - 2.9e-45 154.2 0.1 8.5e-45 152.7 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.6 CDI83008.1 - 7.1e-19 67.8 0.3 1.3e-18 66.9 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 CDI83008.1 - 2.7e-08 34.2 1.0 0.00045 20.5 0.1 3.7 3 1 1 4 4 4 2 Helicase conserved C-terminal domain ResIII PF04851.15 CDI83008.1 - 0.014 15.4 0.5 0.027 14.5 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TPH PF13868.6 CDI83009.1 - 3.2e-18 65.4 129.9 1.5e-13 50.0 68.6 2.9 2 1 0 2 2 2 2 Trichohyalin-plectin-homology domain CPSase_sm_chain PF00988.22 CDI83009.1 - 0.017 14.9 0.8 0.071 12.9 0.2 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase small chain, CPSase domain ELO PF01151.18 CDI83011.1 - 2.2e-47 161.7 21.1 2.7e-47 161.4 21.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family zf-MYND PF01753.18 CDI83012.1 - 0.00038 20.5 7.9 0.001 19.1 7.9 1.8 1 0 0 1 1 1 1 MYND finger PAS_3 PF08447.12 CDI83016.1 - 0.017 15.4 0.0 2.7 8.3 0.0 2.3 2 0 0 2 2 2 0 PAS fold Ank_5 PF13857.6 CDI83017.1 - 9.2e-21 73.6 0.2 4.3e-12 46.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDI83017.1 - 6.4e-13 48.9 0.8 4.6e-07 30.3 0.1 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDI83017.1 - 1.5e-12 47.9 0.1 5.1e-12 46.2 0.1 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDI83017.1 - 7e-12 45.2 0.1 2.7e-05 24.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CDI83017.1 - 2.9e-09 36.4 0.1 0.00043 20.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat ACBP PF00887.19 CDI83017.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Acyl CoA binding protein PseudoU_synth_2 PF00849.22 CDI83019.1 - 7e-27 94.5 0.0 1e-25 90.7 0.0 2.1 1 1 0 1 1 1 1 RNA pseudouridylate synthase SMYLE_N PF18615.1 CDI83020.1 - 0.41 10.2 8.0 0.84 9.1 8.0 1.4 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Spt20 PF12090.8 CDI83020.1 - 7.8 6.0 20.2 0.27 10.8 12.6 2.2 2 0 0 2 2 2 0 Spt20 family S1 PF00575.23 CDI83025.1 - 0.16 12.3 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 S1 RNA binding domain ATP-synt_J PF04911.12 CDI83028.1 - 0.037 13.6 0.1 17 5.1 0.0 2.9 3 0 0 3 3 3 0 ATP synthase j chain gp12-short_mid PF09089.10 CDI83028.1 - 0.08 13.1 0.2 0.08 13.1 0.2 2.7 3 0 0 3 3 3 0 Phage short tail fibre protein gp12, middle domain CTD PF12815.7 CDI83028.1 - 0.12 13.0 10.4 1.6 9.4 1.0 3.1 2 0 0 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Cadherin_C_2 PF16492.5 CDI83029.1 - 0.1 13.3 0.1 0.29 11.9 0.1 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Chordopox_A33R PF05966.12 CDI83029.1 - 0.17 11.1 0.1 0.29 10.4 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein RIC1 PF07064.13 CDI83031.1 - 0.0019 17.6 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 RIC1 ThiF PF00899.21 CDI83032.1 - 3.1e-58 197.0 0.4 2.6e-19 69.5 0.0 6.4 5 2 1 6 6 6 5 ThiF family UBA_e1_thiolCys PF10585.9 CDI83032.1 - 0.00018 21.5 0.0 4.2 7.2 0.0 3.5 3 0 0 3 3 3 3 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 CDI83032.1 - 0.0045 17.1 0.1 5 7.2 0.1 2.7 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CDI83032.1 - 0.015 14.7 0.0 1.3 8.4 0.0 2.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDI83032.1 - 0.033 13.4 0.2 8.1 5.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDI83032.1 - 0.098 13.2 0.7 7.3 7.2 0.3 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CorA PF01544.18 CDI83033.1 - 0.00018 21.0 1.7 0.0002 20.8 1.7 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Rab5-bind PF09311.11 CDI83033.1 - 0.00046 19.7 1.9 0.00054 19.5 1.9 1.0 1 0 0 1 1 1 1 Rabaptin-like protein Apolipoprotein PF01442.18 CDI83033.1 - 0.00057 19.8 13.4 0.0011 18.9 13.4 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain MIT PF04212.18 CDI83033.1 - 0.00087 19.3 3.1 0.11 12.6 0.6 2.3 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Prefoldin PF02996.17 CDI83033.1 - 0.00099 19.0 4.9 0.0015 18.5 3.2 2.0 2 1 0 2 2 2 1 Prefoldin subunit Spc7 PF08317.11 CDI83033.1 - 0.0025 16.7 3.3 0.0031 16.4 3.3 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein CdvA PF18822.1 CDI83033.1 - 0.0036 17.1 3.4 0.007 16.2 2.9 1.6 1 1 0 1 1 1 1 CdvA-like coiled-coil domain DUF4795 PF16043.5 CDI83033.1 - 0.0038 16.9 1.8 0.0062 16.2 1.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) DUF883 PF05957.13 CDI83033.1 - 0.0042 17.7 6.6 0.0042 17.7 6.6 1.7 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 CDI83033.1 - 0.0044 17.1 2.4 0.0073 16.4 2.4 1.4 1 1 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) BST2 PF16716.5 CDI83033.1 - 0.0049 17.4 3.3 0.85 10.3 0.0 2.2 1 1 1 2 2 2 1 Bone marrow stromal antigen 2 FUSC PF04632.12 CDI83033.1 - 0.0075 14.9 9.8 0.0095 14.5 9.8 1.2 1 0 0 1 1 1 1 Fusaric acid resistance protein family DUF1664 PF07889.12 CDI83033.1 - 0.0084 16.1 2.0 0.019 15.0 1.9 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) PIN_8 PF18476.1 CDI83033.1 - 0.013 15.3 0.8 0.015 15.2 0.8 1.1 1 0 0 1 1 1 0 PIN like domain APG17 PF04108.12 CDI83033.1 - 0.015 14.4 1.5 0.022 13.9 1.4 1.3 1 1 0 1 1 1 0 Autophagy protein Apg17 Gp-FAR-1 PF05823.12 CDI83033.1 - 0.019 15.3 0.6 0.022 15.1 0.6 1.2 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) FIVAR PF07554.13 CDI83033.1 - 0.023 15.5 2.0 0.059 14.1 0.3 2.2 2 1 0 2 2 2 0 FIVAR domain Fib_alpha PF08702.10 CDI83033.1 - 0.03 14.5 0.2 0.035 14.3 0.2 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Phasin PF05597.11 CDI83033.1 - 0.036 14.1 2.0 0.052 13.6 2.0 1.5 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) GrpE PF01025.19 CDI83033.1 - 0.04 13.6 2.8 0.047 13.4 2.8 1.3 1 0 0 1 1 1 0 GrpE FliT PF05400.13 CDI83033.1 - 0.06 14.2 13.4 0.36 11.7 8.9 2.2 1 1 1 2 2 2 0 Flagellar protein FliT Laminin_II PF06009.12 CDI83033.1 - 0.066 13.2 2.9 0.072 13.1 1.7 1.6 1 1 1 2 2 2 0 Laminin Domain II 7TMR-HDED PF07697.11 CDI83033.1 - 0.069 13.3 3.9 0.088 12.9 3.9 1.2 1 0 0 1 1 1 0 7TM-HD extracellular Nsp1_C PF05064.13 CDI83033.1 - 0.07 12.9 2.0 0.13 12.1 2.0 1.5 1 0 0 1 1 1 0 Nsp1-like C-terminal region ApoO PF09769.9 CDI83033.1 - 0.076 13.0 0.3 0.19 11.7 0.3 1.8 1 1 0 1 1 1 0 Apolipoprotein O EAP30 PF04157.16 CDI83033.1 - 0.1 11.9 1.5 0.13 11.5 0.4 1.6 1 1 1 2 2 2 0 EAP30/Vps36 family YtxH PF12732.7 CDI83033.1 - 0.11 13.0 1.1 0.11 13.0 1.1 2.1 1 1 1 2 2 2 0 YtxH-like protein CRISPR_Cse1 PF09481.10 CDI83033.1 - 0.12 11.5 4.2 0.13 11.3 4.2 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) NPV_P10 PF05531.12 CDI83033.1 - 0.12 12.9 3.7 0.2 12.1 3.3 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 CDI83033.1 - 0.12 12.6 2.7 2 8.7 1.6 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4404 PF14357.6 CDI83033.1 - 0.12 13.0 7.4 5.3 7.8 4.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF3987 PF13148.6 CDI83033.1 - 0.13 11.3 5.7 0.17 10.8 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF4407 PF14362.6 CDI83033.1 - 0.15 11.4 6.4 0.17 11.2 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 CDI83033.1 - 0.16 9.9 0.3 0.15 9.9 0.3 1.1 1 0 0 1 1 1 0 Prominin DUF2605 PF10792.9 CDI83033.1 - 0.17 11.9 3.0 0.19 11.7 1.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) Baculo_PEP_C PF04513.12 CDI83033.1 - 0.2 11.7 2.3 0.56 10.2 2.0 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 CDI83033.1 - 0.2 11.7 2.3 0.39 10.8 2.2 1.6 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4735 PF15882.5 CDI83033.1 - 0.25 10.8 0.6 6.2 6.2 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4735) OmpH PF03938.14 CDI83033.1 - 0.66 10.3 9.6 4 7.8 9.6 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF848 PF05852.11 CDI83033.1 - 0.93 9.6 6.5 3.5 7.7 5.9 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CHAD PF05235.14 CDI83033.1 - 0.94 9.4 10.2 4 7.3 4.1 2.0 1 1 1 2 2 2 0 CHAD domain CLZ PF16526.5 CDI83033.1 - 0.97 9.8 8.7 3.3 8.1 3.5 3.2 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels COMP PF11598.8 CDI83033.1 - 1.4 9.4 6.8 2.1 8.9 3.0 2.2 1 1 1 2 2 2 0 Cartilage oligomeric matrix protein ATP-synt_B PF00430.18 CDI83033.1 - 3.3 7.8 13.3 0.45 10.6 9.5 1.6 2 1 0 2 2 1 0 ATP synthase B/B' CF(0) TFIIA PF03153.13 CDI83036.1 - 0.00046 20.3 30.0 0.00059 20.0 30.0 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.6 CDI83036.1 - 0.00081 17.4 23.6 0.00084 17.4 23.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) SPX PF03105.19 CDI83036.1 - 0.0061 16.5 13.6 0.0065 16.4 13.6 1.1 1 0 0 1 1 1 1 SPX domain Macoilin PF09726.9 CDI83036.1 - 0.0083 14.7 11.7 0.0092 14.6 11.7 1.2 1 0 0 1 1 1 1 Macoilin family Peptidase_S64 PF08192.11 CDI83036.1 - 0.014 13.9 13.6 0.013 14.0 13.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF1645 PF07816.11 CDI83036.1 - 0.028 15.0 15.6 0.06 13.9 15.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Apt1 PF10351.9 CDI83036.1 - 0.058 12.2 15.2 0.064 12.1 15.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain ATP11 PF06644.11 CDI83036.1 - 0.11 12.2 18.1 0.17 11.6 18.1 1.2 1 0 0 1 1 1 0 ATP11 protein SpoIIP PF07454.11 CDI83036.1 - 0.16 11.4 14.4 0.25 10.8 14.4 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Lin-8 PF03353.15 CDI83036.1 - 0.28 10.7 23.1 0.38 10.3 23.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Spore_coat_CotO PF14153.6 CDI83036.1 - 0.68 9.8 20.7 1 9.3 20.7 1.4 1 0 0 1 1 1 0 Spore coat protein CotO Connexin PF00029.19 CDI83036.1 - 0.75 9.5 9.8 0.97 9.1 9.8 1.3 1 0 0 1 1 1 0 Connexin PAP1 PF08601.10 CDI83036.1 - 0.79 9.4 19.0 0.88 9.2 19.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 CENP-N PF05238.13 CDI83036.1 - 1 8.6 13.6 0.13 11.6 9.2 1.7 2 0 0 2 2 2 0 Kinetochore protein CHL4 like PAT1 PF09770.9 CDI83036.1 - 1 7.5 26.1 1.2 7.3 26.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 tRNA_lig_CPD PF08302.11 CDI83036.1 - 1.3 8.4 13.2 0.4 10.1 9.8 1.8 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain Endonuc_Holl PF10107.9 CDI83036.1 - 1.3 8.9 10.7 1.9 8.3 10.7 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase SLC12 PF03522.15 CDI83036.1 - 1.6 7.7 15.0 1.9 7.4 15.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 CDI83036.1 - 1.8 7.2 12.6 2 7.0 12.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4770 PF15994.5 CDI83036.1 - 3.3 7.9 14.0 4.9 7.3 14.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF2828 PF11443.8 CDI83036.1 - 3.5 5.6 12.4 4.4 5.3 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3464 PF11947.8 CDI83036.1 - 3.7 7.3 14.1 7.3 6.3 14.1 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TRAP_alpha PF03896.16 CDI83036.1 - 4.2 6.5 9.0 6.3 5.9 9.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit OATP PF03137.20 CDI83036.1 - 4.3 5.5 5.9 5.5 5.2 5.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Activator_LAG-3 PF11498.8 CDI83036.1 - 5.6 5.8 44.2 8 5.3 44.2 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Peptidase_S49_N PF08496.10 CDI83036.1 - 7 6.7 10.6 10 6.1 10.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Sec62 PF03839.16 CDI83036.1 - 7.7 6.0 10.9 9.6 5.6 10.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 CLN3 PF02487.17 CDI83036.1 - 9.5 5.1 11.5 12 4.8 11.5 1.2 1 0 0 1 1 1 0 CLN3 protein Actin PF00022.19 CDI83042.1 - 1.1e-73 248.2 0.0 6.8e-58 196.2 0.0 2.1 1 1 1 2 2 2 2 Actin SUIM_assoc PF16619.5 CDI83042.1 - 0.00046 20.2 0.0 0.00075 19.5 0.0 1.5 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 YajC PF02699.15 CDI83042.1 - 2.3 8.1 6.6 5.4 7.0 6.6 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit RCC1 PF00415.18 CDI83043.1 - 3.5e-70 232.5 41.3 5.8e-13 49.2 0.2 11.6 12 1 0 12 12 12 9 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI83043.1 - 5.3e-30 102.6 56.3 8.9e-08 31.7 0.8 9.3 9 1 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat SUIM_assoc PF16619.5 CDI83043.1 - 4e-05 23.6 9.7 0.048 13.7 3.1 2.8 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI83043.1 - 0.0067 16.5 5.8 0.027 14.5 0.7 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDI83043.1 - 0.04 12.9 8.9 0.26 10.2 4.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI83043.1 - 0.058 13.0 16.8 0.45 10.1 7.4 2.6 3 0 0 3 3 3 0 Spt20 family Med15 PF09606.10 CDI83043.1 - 0.11 11.2 11.6 0.39 9.4 3.9 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4834 PF16118.5 CDI83043.1 - 0.69 10.9 3.8 11 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Sin_N PF04801.13 CDI83043.1 - 3.9 6.6 9.3 11 5.1 3.5 2.1 2 0 0 2 2 2 0 Sin-like protein conserved region UPF1_Zn_bind PF09416.10 CDI83045.1 - 0.63 10.0 12.9 0.73 9.8 12.9 1.1 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) ChapFlgA PF13144.6 CDI83045.1 - 0.75 9.9 12.1 0.86 9.7 12.1 1.1 1 0 0 1 1 1 0 Chaperone for flagella basal body P-ring formation SRPRB PF09439.10 CDI83046.1 - 4.9e-15 55.4 0.0 6.3e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDI83046.1 - 1.2e-05 24.9 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CDI83046.1 - 1.3e-05 24.8 0.0 1.7e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDI83046.1 - 0.022 14.8 0.0 0.036 14.2 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2339 PF10101.9 CDI83046.1 - 0.086 11.4 12.0 0.1 11.1 12.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) FeoB_N PF02421.18 CDI83046.1 - 0.12 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF1192 PF06698.11 CDI83046.1 - 0.16 12.1 0.0 0.16 12.1 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) Adeno_PV PF03910.13 CDI83046.1 - 9.8 4.8 7.5 13 4.3 7.5 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Ribosomal_S9 PF00380.19 CDI83048.1 - 7e-18 65.3 0.0 7e-18 65.3 0.0 2.8 3 0 0 3 3 3 1 Ribosomal protein S9/S16 Cwf_Cwc_15 PF04889.12 CDI83048.1 - 0.035 13.9 0.4 0.035 13.9 0.4 4.1 5 0 0 5 5 5 0 Cwf15/Cwc15 cell cycle control protein Gemini_mov PF01708.16 CDI83048.1 - 0.81 9.5 10.8 0.7 9.7 0.1 4.2 3 0 0 3 3 3 0 Geminivirus putative movement protein Connexin PF00029.19 CDI83048.1 - 5.5 6.7 13.3 3.9 7.2 4.1 3.4 3 0 0 3 3 3 0 Connexin GTP_EFTU PF00009.27 CDI83049.1 - 9.5e-54 181.9 0.0 1.4e-53 181.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDI83049.1 - 5.3e-42 142.7 0.0 2e-41 140.8 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDI83049.1 - 3.9e-15 56.0 1.3 8.2e-15 55.0 0.5 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDI83049.1 - 0.00023 21.2 0.0 0.024 14.7 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase NIF3 PF01784.18 CDI83049.1 - 0.0017 18.0 0.1 0.0033 17.1 0.1 1.4 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) GTP_EFTU_D4 PF14578.6 CDI83049.1 - 0.049 13.5 0.4 0.049 13.5 0.4 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 LCM PF04072.14 CDI83050.1 - 6e-05 23.1 0.1 6.5e-05 23.0 0.1 1.0 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase GAT PF03127.14 CDI83053.1 - 0.17 12.2 1.1 0.62 10.4 0.2 2.3 2 1 0 2 2 2 0 GAT domain Sec23_trunk PF04811.15 CDI83054.1 - 4.6e-21 75.5 0.0 1e-20 74.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CDI83054.1 - 1.1e-14 54.1 0.1 4e-14 52.3 0.1 2.0 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDI83054.1 - 6e-10 39.0 3.2 1.1e-09 38.1 3.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 CDI83054.1 - 0.029 15.1 0.0 0.16 12.7 0.0 2.3 2 0 0 2 2 2 0 Sec23/Sec24 beta-sandwich domain Peptidase_M18 PF02127.15 CDI83055.1 - 1.1e-92 311.2 0.0 4.6e-56 190.4 0.0 3.0 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CDI83055.1 - 9.1e-07 28.2 0.0 3.4e-06 26.3 0.0 1.9 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase DUF3333 PF11812.8 CDI83055.1 - 0.058 13.6 0.0 0.15 12.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) Actin PF00022.19 CDI83056.1 - 8.7e-27 93.7 0.0 1.1e-23 83.5 0.0 2.9 2 1 0 2 2 2 2 Actin Homez PF11569.8 CDI83057.1 - 0.15 11.6 0.3 2.7 7.5 0.8 2.1 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez PPR_2 PF13041.6 CDI83058.1 - 6.4e-50 167.1 4.9 3.4e-15 56.0 0.0 7.3 3 1 4 7 7 7 6 PPR repeat family PPR PF01535.20 CDI83058.1 - 1.7e-37 125.1 8.3 5.8e-06 26.2 0.0 8.9 8 1 1 9 9 9 7 PPR repeat PPR_3 PF13812.6 CDI83058.1 - 4.3e-35 119.6 0.1 7.3e-14 51.6 0.0 4.3 4 0 0 4 4 4 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 CDI83058.1 - 3.9e-30 103.2 0.5 2.1e-08 33.7 0.0 6.7 6 0 0 6 6 6 5 PPR repeat PPR_long PF17177.4 CDI83058.1 - 4.6e-21 75.2 0.1 1.3e-13 50.8 0.0 2.3 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 CDI83058.1 - 0.0053 16.6 0.0 4.8 7.1 0.0 3.1 2 1 0 3 3 3 2 Mitochondrial ATPase expression RILP PF11461.8 CDI83059.1 - 2.7e-06 27.5 7.6 0.079 13.2 0.2 5.9 4 0 0 4 4 4 3 Rab interacting lysosomal protein APG6_N PF17675.1 CDI83059.1 - 0.00038 21.0 22.6 0.00038 21.0 22.6 9.6 7 2 1 9 9 9 3 Apg6 coiled-coil region HALZ PF02183.18 CDI83059.1 - 0.044 14.0 0.4 0.044 14.0 0.4 12.4 10 3 1 11 11 11 0 Homeobox associated leucine zipper TraF_2 PF13729.6 CDI83059.1 - 0.49 9.7 5.0 31 3.8 0.0 4.1 4 0 0 4 4 4 0 F plasmid transfer operon, TraF, protein DUF2353 PF09789.9 CDI83059.1 - 7.9 5.7 64.8 0.11 11.8 0.7 6.3 6 1 0 6 6 6 0 Uncharacterized coiled-coil protein (DUF2353) zf-CCCH_4 PF18044.1 CDI83062.1 - 0.11 12.4 0.4 2.3 8.1 0.1 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger NIF PF03031.18 CDI83064.1 - 4.7e-10 39.5 0.0 3.8e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase RskA PF10099.9 CDI83064.1 - 0.00012 22.4 8.9 0.00012 22.4 8.9 4.2 1 1 2 3 3 3 1 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI83064.1 - 0.058 14.4 0.8 0.058 14.4 0.8 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4647 PF15504.6 CDI83064.1 - 3 6.9 12.9 4.7 6.2 12.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) UDPGP PF01704.18 CDI83067.1 - 3.8e-18 65.3 0.0 8.3e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Androgen_recep PF02166.16 CDI83067.1 - 1.1 8.0 9.2 1.8 7.3 9.2 1.2 1 0 0 1 1 1 0 Androgen receptor IPK PF03770.16 CDI83068.1 - 2e-24 86.5 0.0 2e-24 86.5 0.0 4.7 5 0 0 5 5 5 1 Inositol polyphosphate kinase Sin_N PF04801.13 CDI83068.1 - 1.7e-06 27.5 52.0 0.082 12.1 0.0 6.4 6 2 0 6 6 6 1 Sin-like protein conserved region DUF4164 PF13747.6 CDI83069.1 - 0.034 14.4 4.7 0.034 14.4 4.7 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4164) Intimin_C PF07979.11 CDI83069.1 - 0.048 14.1 0.3 0.16 12.4 0.2 1.8 1 1 0 1 1 1 0 Intimin C-type lectin domain PriA_3primeBD PF17764.1 CDI83069.1 - 0.21 11.5 4.9 4.7 7.2 0.1 3.1 2 1 1 3 3 3 0 3′ DNA-binding domain (3′BD) FUSC PF04632.12 CDI83069.1 - 0.49 8.9 16.4 0.61 8.6 16.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Dus PF01207.17 CDI83070.1 - 5.7e-08 32.2 0.0 5.7e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Kei1 PF08552.11 CDI83077.1 - 0.15 12.0 3.5 0.18 11.7 3.5 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Tic110 PF16940.5 CDI83077.1 - 0.52 8.7 3.4 0.55 8.6 3.4 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter MSP1_C PF07462.11 CDI83077.1 - 0.99 8.0 4.5 1.1 7.9 4.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus S1-P1_nuclease PF02265.16 CDI83078.1 - 0.0017 18.2 0.0 0.0017 18.2 0.0 3.4 2 1 0 3 3 3 1 S1/P1 Nuclease Caldesmon PF02029.15 CDI83078.1 - 0.91 8.2 48.4 1.1 7.9 48.4 1.1 1 0 0 1 1 1 0 Caldesmon Dapper PF15268.6 CDI83078.1 - 2.2 7.1 37.9 2.7 6.8 37.9 1.1 1 0 0 1 1 1 0 Dapper AF-4 PF05110.13 CDI83078.1 - 2.2 6.2 41.9 2.7 6.0 41.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAT1 PF09770.9 CDI83078.1 - 3.2 5.9 44.1 4.3 5.5 44.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tubulin_C PF03953.17 CDI83082.1 - 7.9e-41 139.2 0.2 1.6e-40 138.2 0.2 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 CDI83082.1 - 1.6e-33 116.6 0.0 2.6e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 CDI83082.1 - 0.0044 16.3 0.0 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Glycos_transf_3 PF00591.21 CDI83083.1 - 0.13 11.8 1.3 0.16 11.5 1.3 1.1 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain RNA_pol_3_Rpc31 PF11705.8 CDI83084.1 - 0.084 13.1 16.7 0.15 12.3 16.7 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DNA_pol_phi PF04931.13 CDI83084.1 - 1.4 6.9 19.2 2 6.4 19.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_60s PF00428.19 CDI83086.1 - 3.2 8.4 13.2 0.84 10.3 9.7 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein FANCA_interact PF15751.5 CDI83090.1 - 0.13 12.8 0.4 0.18 12.3 0.4 1.2 1 0 0 1 1 1 0 FAAP20 FANCA interaction domain DUF1772 PF08592.11 CDI83094.1 - 0.0022 18.3 2.5 0.003 17.9 1.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1772) SARAF PF06682.12 CDI83094.1 - 3.7 7.1 20.1 46 3.5 20.1 2.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis K_channel_TID PF07941.11 CDI83095.1 - 6.4 7.3 7.5 29 5.2 2.0 3.0 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain MutS_III PF05192.18 CDI83097.1 - 5.1e-15 56.2 0.5 1.1e-14 55.2 0.5 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CDI83097.1 - 0.0025 18.1 1.3 0.025 14.9 0.1 2.9 3 0 0 3 3 3 1 MutS family domain IV DUF429 PF04250.13 CDI83097.1 - 2.2 8.0 8.2 0.13 12.1 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF429) AAA_23 PF13476.6 CDI83098.1 - 1 9.8 10.3 2.3 8.7 4.0 2.2 2 0 0 2 2 2 0 AAA domain PIG-Y PF15159.6 CDI83099.1 - 3.7e-08 34.2 10.6 4.8e-08 33.8 10.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Gpi16 PF04113.14 CDI83101.1 - 7.3e-19 67.6 20.1 2.6e-17 62.5 20.1 2.4 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Otopetrin PF03189.13 CDI83101.1 - 2.9e-05 23.1 0.8 5.6e-05 22.1 0.2 1.7 2 0 0 2 2 2 1 Otopetrin Activator_LAG-3 PF11498.8 CDI83101.1 - 0.0013 17.8 10.6 0.0013 17.8 10.6 7.1 7 0 0 7 7 7 1 Transcriptional activator LAG-3 Ribosomal_S2 PF00318.20 CDI83101.1 - 1.8 7.8 3.8 2.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein S2 RAP1 PF07218.11 CDI83101.1 - 5 5.3 8.2 7.6 4.7 8.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Peptidase_C2 PF00648.21 CDI83102.1 - 8.4e-36 123.5 2.6 2.3e-30 105.6 0.0 3.4 3 1 0 3 3 3 2 Calpain family cysteine protease Calpain_III PF01067.22 CDI83102.1 - 0.00058 20.1 0.0 0.00058 20.1 0.0 4.8 7 0 0 7 7 7 2 Calpain large subunit, domain III MAR_sialic_bdg PF10564.9 CDI83106.1 - 1.1e-99 326.7 31.9 4.6e-28 97.1 2.7 4.9 5 0 0 5 5 5 4 Sialic-acid binding micronemal adhesive repeat Calci_bind_CcbP PF11535.8 CDI83106.1 - 0.1 13.1 0.0 1.3e+02 3.1 0.0 4.3 5 0 0 5 5 5 0 Calcium binding DSL PF01414.19 CDI83106.1 - 1.5 9.2 12.1 4.3 7.7 0.3 4.4 4 0 0 4 4 4 0 Delta serrate ligand TFIIA PF03153.13 CDI83107.1 - 0.085 12.8 22.5 0.1 12.6 22.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF775 PF05603.12 CDI83107.1 - 0.14 11.6 6.2 0.17 11.4 6.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) EPL1 PF10513.9 CDI83107.1 - 0.47 10.8 12.0 0.74 10.2 12.0 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like FTZ PF03867.14 CDI83107.1 - 0.96 8.9 9.5 1.2 8.7 9.5 1.1 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Peptidase_S64 PF08192.11 CDI83107.1 - 1.7 7.0 12.7 1.8 6.9 12.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 Ndc1_Nup PF09531.10 CDI83107.1 - 1.8 7.2 8.6 2 7.0 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Androgen_recep PF02166.16 CDI83107.1 - 4.4 6.0 17.2 5.5 5.7 17.2 1.2 1 0 0 1 1 1 0 Androgen receptor Activator_LAG-3 PF11498.8 CDI83108.1 - 0.057 12.4 38.3 0.16 10.9 38.3 1.8 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Connexin PF00029.19 CDI83108.1 - 0.91 9.2 5.6 1.4 8.6 5.6 1.3 1 0 0 1 1 1 0 Connexin ANAPC4_WD40 PF12894.7 CDI83110.1 - 7.1e-08 32.6 0.0 0.015 15.6 0.0 4.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI83110.1 - 0.00067 20.4 1.1 14 6.8 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat PUF PF00806.19 CDI83111.1 - 4.9e-45 148.7 1.4 1.1e-06 28.0 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Pkinase PF00069.25 CDI83112.1 - 1.7e-39 135.8 0.0 6.6e-26 91.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83112.1 - 1.6e-18 67.0 0.0 1.4e-12 47.5 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDI83112.1 - 9.9e-06 25.1 0.0 0.14 11.5 0.0 3.2 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 CDI83112.1 - 0.00021 21.3 8.7 0.00033 20.7 0.2 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 CDI83112.1 - 0.0012 18.2 0.3 0.0012 18.2 0.3 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIA PF03153.13 CDI83112.1 - 0.18 11.7 31.8 0.04 13.9 8.1 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 CDI83112.1 - 3.6 6.0 16.1 1.3 7.5 5.3 2.1 2 0 0 2 2 2 0 Macoilin family SUIM_assoc PF16619.5 CDI83115.1 - 0.0013 18.8 14.9 0.0013 18.8 14.9 2.1 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI83115.1 - 0.43 10.1 16.2 0.48 10.0 16.2 1.1 1 0 0 1 1 1 0 Spt20 family CBFD_NFYB_HMF PF00808.23 CDI83117.1 - 0.057 13.7 0.8 0.12 12.7 0.3 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TetR_C_36 PF18598.1 CDI83119.1 - 0.037 14.0 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain IMUP PF15761.5 CDI83121.1 - 0.011 16.4 2.2 0.017 15.8 2.2 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein CCSAP PF15748.5 CDI83121.1 - 0.036 14.2 15.8 0.041 14.0 15.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Pannexin_like PF12534.8 CDI83121.1 - 0.82 8.7 9.2 0.97 8.5 9.2 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 eIF3_subunit PF08597.10 CDI83121.1 - 3.4 7.5 12.8 3.8 7.3 12.8 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Exonuc_VII_L PF02601.15 CDI83121.1 - 5.3 6.5 15.1 6 6.3 15.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4834 PF16118.5 CDI83123.1 - 2.3 9.2 8.8 5.7 8.0 1.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) WBP-1 PF11669.8 CDI83123.1 - 4.4 8.0 7.7 1.4 9.6 1.8 2.5 2 0 0 2 2 2 0 WW domain-binding protein 1 TMEM51 PF15345.6 CDI83124.1 - 0.0064 16.4 4.4 0.0083 16.0 4.4 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 TFIIA PF03153.13 CDI83124.1 - 0.034 14.2 20.4 0.037 14.0 20.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI83124.1 - 0.035 12.9 2.0 0.029 13.1 2.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4175 PF13779.6 CDI83124.1 - 0.039 11.9 19.3 0.04 11.8 19.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EIIBC-GUT_N PF03612.14 CDI83124.1 - 0.058 13.1 3.3 0.066 13.0 3.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pex14_N PF04695.13 CDI83124.1 - 0.059 14.0 8.8 0.065 13.9 8.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DcuA_DcuB PF03605.14 CDI83124.1 - 0.068 12.0 0.2 0.079 11.8 0.2 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Suf PF05843.14 CDI83124.1 - 0.098 12.6 8.3 0.12 12.4 8.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2722 PF10846.8 CDI83124.1 - 0.17 10.8 19.9 0.2 10.6 19.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Dpy19 PF10034.9 CDI83124.1 - 0.18 10.0 1.1 0.21 9.8 1.1 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation eIF-3_zeta PF05091.12 CDI83124.1 - 0.19 10.6 8.7 0.22 10.4 8.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TERB2 PF15101.6 CDI83124.1 - 0.24 11.4 7.9 0.26 11.3 7.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Spt20 PF12090.8 CDI83124.1 - 0.35 10.4 28.4 0.48 10.0 28.4 1.1 1 0 0 1 1 1 0 Spt20 family EPL1 PF10513.9 CDI83124.1 - 0.38 11.1 6.0 0.43 11.0 6.0 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4834 PF16118.5 CDI83124.1 - 0.38 11.7 8.4 0.51 11.3 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Band_3_cyto PF07565.13 CDI83124.1 - 0.41 10.4 4.4 0.44 10.3 4.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Orf78 PF06024.12 CDI83124.1 - 0.42 10.9 1.3 0.56 10.5 1.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) ABC2_membrane_2 PF12679.7 CDI83124.1 - 0.45 9.7 1.9 0.55 9.5 1.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Neur_chan_memb PF02932.16 CDI83124.1 - 0.47 10.5 2.9 0.49 10.4 2.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 CDI83124.1 - 1.4 8.2 12.4 1.8 7.9 12.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT UPF0560 PF10577.9 CDI83124.1 - 1.6 7.1 11.9 1.7 7.1 11.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 dsDNA_bind PF01984.20 CDI83124.1 - 8.4 6.7 21.3 12 6.2 21.3 1.3 1 0 0 1 1 1 0 Double-stranded DNA-binding domain Tubulin PF00091.25 CDI83125.1 - 1.2e-12 48.4 0.0 1.6e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Sec1 PF00995.23 CDI83126.1 - 3.4e-73 247.8 0.0 4.7e-73 247.3 0.0 1.1 1 0 0 1 1 1 1 Sec1 family AIRC PF00731.20 CDI83126.1 - 0.013 15.1 0.3 0.032 13.8 0.3 1.6 1 0 0 1 1 1 0 AIR carboxylase cEGF PF12662.7 CDI83142.1 - 0.016 15.1 1.8 0.016 15.1 1.8 7.3 7 2 0 7 7 7 0 Complement Clr-like EGF-like Mito_carr PF00153.27 CDI83143.1 - 3.1e-37 126.4 2.1 7.3e-18 64.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PUB PF09409.10 CDI83144.1 - 0.00044 20.1 0.0 0.0007 19.5 0.0 1.3 1 0 0 1 1 1 1 PUB domain EF-hand_1 PF00036.32 CDI83145.1 - 1.4e-27 93.1 4.7 1.9e-07 30.1 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 CDI83145.1 - 4.7e-25 85.9 2.5 5.6e-07 28.8 0.3 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 CDI83145.1 - 6.9e-24 84.1 3.1 2.8e-12 46.9 0.5 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI83145.1 - 7e-21 72.3 4.4 0.00084 19.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDI83145.1 - 1.8e-12 46.9 8.8 3.7e-05 23.5 1.4 4.6 4 1 1 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDI83145.1 - 1.5e-09 38.2 0.0 0.0003 21.1 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDI83145.1 - 6.3e-05 22.9 2.3 0.15 12.0 0.4 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDI83145.1 - 0.0002 21.5 3.7 0.0086 16.2 0.1 3.7 2 1 2 4 4 4 3 Dockerin type I domain EF-hand_9 PF14658.6 CDI83145.1 - 0.00076 19.8 0.0 0.048 14.0 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain NOD2_WH PF17779.1 CDI83145.1 - 0.031 14.6 0.1 1.6 9.1 0.0 2.7 3 0 0 3 3 3 0 NOD2 winged helix domain Caleosin PF05042.13 CDI83145.1 - 0.059 13.3 1.3 4.6 7.2 0.0 3.2 2 1 2 4 4 4 0 Caleosin related protein BDV_P40 PF06407.11 CDI83145.1 - 0.1 11.7 0.0 0.28 10.3 0.0 1.7 2 0 0 2 2 2 0 Borna disease virus P40 protein DUF3104 PF11302.8 CDI83147.1 - 0.04 13.7 0.2 0.087 12.6 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) Glyco_transf_90 PF05686.12 CDI83148.1 - 3.7e-46 157.8 0.0 6e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 90 Thioredoxin PF00085.20 CDI83148.1 - 1.8e-15 56.7 0.0 4.5e-15 55.5 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDI83148.1 - 0.0067 16.9 0.0 0.02 15.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDI83148.1 - 0.019 15.1 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like FleQ PF06490.11 CDI83152.1 - 0.067 13.6 0.0 0.094 13.1 0.0 1.2 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ Apt1 PF10351.9 CDI83155.1 - 0.3 9.9 5.6 0.34 9.7 5.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI83155.1 - 0.31 9.5 10.5 0.5 8.9 10.5 1.4 1 0 0 1 1 1 0 Macoilin family Sec3_C PF09763.9 CDI83155.1 - 0.43 8.9 3.2 0.57 8.5 3.2 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Presenilin PF01080.17 CDI83155.1 - 4.8 5.8 7.1 6.3 5.4 7.1 1.2 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 CDI83155.1 - 6.9 7.3 18.9 14 6.3 18.9 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Period_C PF12114.8 CDI83155.1 - 8.8 5.9 19.1 26 4.3 19.1 1.8 1 0 0 1 1 1 0 Period protein 2/3C-terminal region AAA PF00004.29 CDI83156.1 - 6.8e-17 62.1 0.0 9.5e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDI83156.1 - 1.6e-07 31.4 0.0 3e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI83156.1 - 4.2e-06 27.2 0.0 1.2e-05 25.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 CDI83156.1 - 9.1e-06 25.9 0.0 2.5e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDI83156.1 - 3.1e-05 24.3 0.1 0.00096 19.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDI83156.1 - 0.00018 21.3 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein NTPase_1 PF03266.15 CDI83156.1 - 0.0014 18.6 0.1 0.022 14.7 0.0 2.0 1 1 1 2 2 2 1 NTPase AAA_33 PF13671.6 CDI83156.1 - 0.0017 18.5 0.0 0.0022 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDI83156.1 - 0.0019 18.7 0.0 0.0021 18.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CDI83156.1 - 0.003 17.6 0.0 0.0035 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CDI83156.1 - 0.0039 17.1 0.1 0.0083 16.1 0.1 1.8 1 1 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 CDI83156.1 - 0.0043 17.4 0.0 0.0059 17.0 0.0 1.3 1 0 0 1 1 1 1 RNA helicase RuvB_N PF05496.12 CDI83156.1 - 0.0051 16.6 0.0 0.012 15.4 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 CDI83156.1 - 0.0066 16.9 0.0 0.0091 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CDI83156.1 - 0.0091 15.9 0.0 0.02 14.7 0.0 1.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 CDI83156.1 - 0.036 14.1 0.0 0.036 14.1 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_7 PF12775.7 CDI83156.1 - 0.067 12.7 0.0 0.099 12.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 CDI83156.1 - 0.086 12.7 0.1 0.19 11.6 0.0 1.6 2 0 0 2 2 1 0 RsgA GTPase ParA PF10609.9 CDI83156.1 - 0.098 12.1 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase NB-ARC PF00931.22 CDI83156.1 - 0.11 11.7 0.0 0.56 9.4 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.27 CDI83156.1 - 0.11 13.0 0.0 0.23 12.0 0.0 1.3 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 CDI83156.1 - 0.12 12.1 0.0 0.14 11.9 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDI83156.1 - 0.14 12.5 0.0 0.47 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CDI83156.1 - 0.15 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CDI83156.1 - 0.17 11.6 0.2 0.27 10.9 0.0 1.4 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 CDI83156.1 - 0.2 11.0 0.0 0.36 10.2 0.0 1.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDI83156.1 - 0.21 11.8 0.0 0.31 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CDI83156.1 - 0.23 10.9 0.0 0.34 10.3 0.0 1.3 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_PrkA PF08298.11 CDI83156.1 - 0.25 10.2 0.0 0.31 9.9 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain REPA_OB_2 PF16900.5 CDI83163.1 - 6.2e-18 64.5 0.2 6.2e-14 51.7 0.0 2.4 2 0 0 2 2 2 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 CDI83163.1 - 6.5e-08 32.4 0.0 5.4e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Rep_fac-A_C PF08646.10 CDI83163.1 - 0.0046 16.7 0.6 0.045 13.5 0.0 2.4 2 0 0 2 2 2 1 Replication factor-A C terminal domain zinc-ribbons_6 PF07191.12 CDI83163.1 - 0.055 13.5 1.0 0.12 12.4 1.0 1.4 1 0 0 1 1 1 0 zinc-ribbons Pantoate_transf PF02548.15 CDI83164.1 - 4e-45 154.2 7.2 4.2e-23 82.0 0.3 3.7 2 1 1 3 3 3 3 Ketopantoate hydroxymethyltransferase ApbA_C PF08546.11 CDI83164.1 - 3e-24 85.6 0.1 5.9e-24 84.6 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal G6PD_C PF02781.16 CDI83165.1 - 5.7e-51 173.4 0.0 7.2e-41 140.3 0.0 2.9 1 1 1 2 2 2 2 Glucose-6-phosphate dehydrogenase, C-terminal domain Glucosamine_iso PF01182.20 CDI83165.1 - 4.2e-30 105.3 0.0 7.3e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_N PF00479.22 CDI83165.1 - 1.7e-19 71.2 0.0 4e-19 69.9 0.0 1.6 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain TIP49 PF06068.13 CDI83166.1 - 1.3e-158 527.8 0.0 1.6e-158 527.5 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDI83166.1 - 5.8e-16 58.4 0.7 1.2e-14 54.1 0.7 2.9 1 1 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 CDI83166.1 - 8.5e-13 48.9 0.0 1.2e-08 35.4 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI83166.1 - 2.6e-10 40.2 0.2 2.7e-07 30.5 0.1 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDI83166.1 - 2.1e-06 28.1 0.1 0.031 14.5 0.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDI83166.1 - 9e-06 25.7 0.1 0.0015 18.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI83166.1 - 1.3e-05 25.7 0.0 0.0018 18.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 CDI83166.1 - 0.0002 21.7 0.1 0.079 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CDI83166.1 - 0.00045 19.7 0.3 0.017 14.5 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CDI83166.1 - 0.00073 19.2 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CDI83166.1 - 0.00078 19.2 0.1 0.4 10.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.6 CDI83166.1 - 0.0011 19.5 0.0 0.0035 17.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 CDI83166.1 - 0.0028 17.8 0.0 0.037 14.2 0.0 2.5 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 CDI83166.1 - 0.0031 17.3 0.0 0.0061 16.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DnaB_C PF03796.15 CDI83166.1 - 0.0033 16.8 0.0 0.0064 15.8 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_7 PF12775.7 CDI83166.1 - 0.0036 16.8 0.0 0.023 14.2 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 CDI83166.1 - 0.0057 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CDI83166.1 - 0.0075 16.3 0.1 0.17 11.8 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 CDI83166.1 - 0.011 15.0 0.1 0.029 13.7 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 CDI83166.1 - 0.011 15.7 0.0 6.6 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CDI83166.1 - 0.016 14.3 0.3 0.039 13.0 0.1 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 CDI83166.1 - 0.025 14.3 0.5 0.45 10.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.9 CDI83166.1 - 0.026 13.8 0.0 0.062 12.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 CDI83166.1 - 0.027 14.5 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 CDI83166.1 - 0.028 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 CDI83166.1 - 0.031 13.4 0.0 1.8 7.7 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase RNA_helicase PF00910.22 CDI83166.1 - 0.038 14.4 0.0 0.093 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 CDI83166.1 - 0.044 13.7 0.2 0.17 11.8 0.0 2.0 2 1 0 2 2 1 0 Rad17 P-loop domain PhoH PF02562.16 CDI83166.1 - 0.045 13.2 0.1 0.091 12.2 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein NTPase_1 PF03266.15 CDI83166.1 - 0.054 13.4 0.1 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 CDI83166.1 - 0.058 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 CDI83166.1 - 0.071 13.5 0.1 0.47 10.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 CDI83166.1 - 0.072 12.5 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein Torsin PF06309.11 CDI83166.1 - 0.073 13.2 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Torsin GvpD PF07088.11 CDI83166.1 - 0.12 10.9 0.0 1.3 7.5 0.0 2.0 2 0 0 2 2 2 0 GvpD gas vesicle protein SAS-6_N PF16531.5 CDI83167.1 - 7.5e-22 77.7 1.5 1.5e-21 76.8 1.5 1.5 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal Enterotoxin_b PF01376.18 CDI83168.1 - 0.056 13.6 0.7 27 5.0 0.0 3.2 1 1 2 3 3 3 0 Heat-labile enterotoxin beta chain UPF0242 PF06785.11 CDI83169.1 - 0.017 15.2 16.9 0.02 15.0 16.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FAM25 PF15825.5 CDI83169.1 - 0.063 13.6 0.2 0.12 12.7 0.1 1.6 1 1 0 1 1 1 0 FAM25 family DUF874 PF05917.11 CDI83169.1 - 0.78 8.7 8.8 0.93 8.5 8.8 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) AAA_11 PF13086.6 CDI83169.1 - 0.97 9.2 10.0 1.1 8.9 10.0 1.1 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 CDI83169.1 - 2.2 7.8 10.2 2.6 7.5 10.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALMT PF11744.8 CDI83169.1 - 2.4 6.9 4.9 2.6 6.8 4.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF641 PF04859.12 CDI83169.1 - 2.5 8.4 15.1 0.32 11.3 7.4 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FUSC PF04632.12 CDI83169.1 - 3.6 6.0 9.2 4.3 5.7 9.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family LMBR1 PF04791.16 CDI83169.1 - 4.1 6.2 6.2 5 5.9 6.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Presenilin PF01080.17 CDI83169.1 - 5.6 5.6 7.4 6.4 5.4 7.4 1.1 1 0 0 1 1 1 0 Presenilin Usp PF00582.26 CDI83169.1 - 6.8 7.2 7.5 9.5 6.7 7.5 1.2 1 0 0 1 1 1 0 Universal stress protein family Pkinase PF00069.25 CDI83170.1 - 7.5e-13 48.4 6.8 7.2e-10 38.7 0.0 3.8 1 1 4 5 5 5 1 Protein kinase domain APH PF01636.23 CDI83170.1 - 1.5e-07 31.6 22.3 2.7e-06 27.5 7.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF5345 PF17280.2 CDI83170.1 - 8e-07 29.0 17.6 0.0027 17.7 4.8 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5345) Dynactin_p62 PF05502.13 CDI83170.1 - 1.6e-06 27.2 8.4 0.0037 16.1 0.9 2.1 2 0 0 2 2 2 2 Dynactin p62 family Presenilin PF01080.17 CDI83170.1 - 6.2e-05 21.9 12.5 7.8e-05 21.6 12.5 1.1 1 0 0 1 1 1 1 Presenilin Pex14_N PF04695.13 CDI83170.1 - 0.00025 21.8 27.7 0.06 14.0 9.9 2.1 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF719 PF05334.13 CDI83170.1 - 0.00073 19.8 14.3 0.056 13.6 2.7 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF719) SPX PF03105.19 CDI83170.1 - 0.0012 18.9 7.5 0.0013 18.7 7.5 1.1 1 0 0 1 1 1 1 SPX domain FemAB PF02388.16 CDI83170.1 - 0.0012 17.8 17.4 0.004 16.1 3.2 2.0 2 0 0 2 2 2 2 FemAB family Utp13 PF08625.11 CDI83170.1 - 0.0012 18.7 7.6 0.15 12.0 0.6 2.2 2 0 0 2 2 2 2 Utp13 specific WD40 associated domain Pkinase_Tyr PF07714.17 CDI83170.1 - 0.0014 17.9 4.9 0.0014 17.9 4.9 2.6 1 1 1 2 2 2 1 Protein tyrosine kinase Orf78 PF06024.12 CDI83170.1 - 0.0025 18.1 2.2 1.2 9.5 0.1 2.3 2 0 0 2 2 2 1 Orf78 (ac78) Eapp_C PF10238.9 CDI83170.1 - 0.0026 17.9 11.3 0.18 11.9 1.6 2.1 2 0 0 2 2 2 2 E2F-associated phosphoprotein PSD4 PF07631.11 CDI83170.1 - 0.0059 17.1 14.6 0.32 11.5 3.4 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1592) DUF4366 PF14283.6 CDI83170.1 - 0.0068 16.5 5.1 0.62 10.1 0.2 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4366) SLC12 PF03522.15 CDI83170.1 - 0.013 14.6 12.9 0.017 14.2 12.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF2407 PF10302.9 CDI83170.1 - 0.024 15.2 10.6 1 10.0 1.8 2.4 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain MDM10 PF12519.8 CDI83170.1 - 0.029 13.3 9.6 0.038 12.9 9.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF5523 PF17661.1 CDI83170.1 - 0.032 13.9 16.8 0.39 10.4 4.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RED_N PF07808.13 CDI83170.1 - 0.033 13.8 19.5 0.17 11.4 4.1 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region DotU PF09850.9 CDI83170.1 - 0.045 13.5 10.6 0.2 11.3 1.0 2.1 2 0 0 2 2 2 0 Type VI secretion system protein DotU Rsc14 PF08586.10 CDI83170.1 - 0.067 14.0 10.5 0.92 10.4 1.0 2.3 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Otopetrin PF03189.13 CDI83170.1 - 0.071 11.9 3.4 0.11 11.4 3.4 1.2 1 0 0 1 1 1 0 Otopetrin BBS2_C PF14782.6 CDI83170.1 - 0.092 11.5 16.1 0.16 10.7 3.0 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal OmpH PF03938.14 CDI83170.1 - 0.11 12.8 42.1 0.25 11.7 15.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1764 PF08576.10 CDI83170.1 - 0.13 13.2 12.4 1.7 9.6 2.2 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) RR_TM4-6 PF06459.12 CDI83170.1 - 0.13 12.1 16.1 0.5 10.2 3.3 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 EPL1 PF10513.9 CDI83170.1 - 0.14 12.6 19.7 0.6 10.5 5.0 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like PRC2_HTH_1 PF18118.1 CDI83170.1 - 0.2 12.5 10.5 2.3 9.1 1.4 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain CbtA PF09490.10 CDI83170.1 - 0.2 11.4 2.2 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) TFIIA PF03153.13 CDI83170.1 - 0.22 11.5 58.1 0.2 11.7 22.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF2052 PF09747.9 CDI83170.1 - 0.23 11.5 19.5 0.47 10.6 4.1 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) V_ATPase_I PF01496.19 CDI83170.1 - 0.24 9.3 18.9 0.28 9.0 4.3 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Peroxin-13_N PF04088.13 CDI83170.1 - 0.26 11.5 8.5 1.3 9.3 0.8 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region DASH_Spc19 PF08287.11 CDI83170.1 - 0.28 11.1 24.3 0.49 10.3 6.5 2.1 2 0 0 2 2 2 0 Spc19 CTU2 PF10288.9 CDI83170.1 - 0.31 11.3 13.8 1 9.6 2.0 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Codanin-1_C PF15296.6 CDI83170.1 - 0.33 11.0 21.5 0.54 10.3 5.2 2.3 2 0 0 2 2 2 0 Codanin-1 C-terminus DUF4834 PF16118.5 CDI83170.1 - 0.44 11.5 19.0 0.26 12.3 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Coilin_N PF15862.5 CDI83170.1 - 0.45 10.3 16.4 0.15 11.8 0.8 2.2 2 0 0 2 2 2 0 Coilin N-terminus ARF7EP_C PF14949.6 CDI83170.1 - 0.53 10.9 12.5 2 9.0 1.4 2.2 2 0 0 2 2 2 0 ARF7 effector protein C-terminus MDM31_MDM32 PF08118.11 CDI83170.1 - 0.56 8.8 12.9 0.13 10.9 0.8 2.1 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins Rxt3 PF08642.10 CDI83170.1 - 0.57 11.0 9.1 3.8 8.3 1.0 2.2 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 OATP PF03137.20 CDI83170.1 - 0.66 8.2 8.6 2 6.6 1.3 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4746 PF15928.5 CDI83170.1 - 0.75 9.2 16.2 0.42 10.0 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF5327 PF17261.2 CDI83170.1 - 0.78 10.5 32.9 2.1 9.1 11.9 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) FAM176 PF14851.6 CDI83170.1 - 1.2 8.8 8.1 5.4 6.7 0.8 2.2 2 0 0 2 2 2 0 FAM176 family Myco_haema PF05692.12 CDI83170.1 - 1.3 8.0 7.0 3.1 6.7 0.9 2.0 2 0 0 2 2 2 0 Mycoplasma haemagglutinin Ndc1_Nup PF09531.10 CDI83170.1 - 1.3 7.7 16.2 1.7 7.3 16.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ORC5_C PF14630.6 CDI83170.1 - 1.5 8.3 11.6 0.46 9.9 1.3 2.1 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus ATP11 PF06644.11 CDI83170.1 - 1.5 8.5 24.1 2.9 7.6 7.8 2.1 2 0 0 2 2 2 0 ATP11 protein DUF3381 PF11861.8 CDI83170.1 - 1.7 8.4 24.9 3.1 7.6 8.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) PTPRCAP PF15713.5 CDI83170.1 - 1.9 8.8 23.7 4.1 7.7 7.6 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated PEX11 PF05648.14 CDI83170.1 - 2 7.8 12.4 4.2 6.8 2.1 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DnaJ-X PF14308.6 CDI83170.1 - 2.2 7.7 14.5 0.95 8.9 2.3 2.1 2 0 0 2 2 2 0 X-domain of DnaJ-containing EIIBC-GUT_N PF03612.14 CDI83170.1 - 2.2 8.0 19.2 3.6 7.3 5.3 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4446 PF14584.6 CDI83170.1 - 2.3 8.2 7.0 4.7 7.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Tom37_C PF11801.8 CDI83170.1 - 2.5 8.0 23.6 1.1 9.3 1.1 3.3 1 1 2 3 3 2 0 Tom37 C-terminal domain ESM4 PF15952.5 CDI83170.1 - 2.6 8.4 34.4 2.5 8.5 12.1 2.1 2 0 0 2 2 2 0 Enhancer of split M4 family MMR1 PF08505.10 CDI83170.1 - 3.4 7.9 30.3 2.3 8.4 9.8 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein F-protein PF00469.20 CDI83170.1 - 3.6 7.1 15.0 1.8 8.1 2.7 2.1 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef DUF3535 PF12054.8 CDI83170.1 - 3.7 6.7 25.4 1.9 7.6 7.8 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF3535) Band_3_cyto PF07565.13 CDI83170.1 - 4.7 6.9 19.0 0.62 9.8 2.7 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain RPA43_OB PF17875.1 CDI83170.1 - 4.8 7.8 11.9 5.4 7.7 1.4 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF1840 PF08895.11 CDI83170.1 - 5.3 7.4 23.4 7.6 6.9 7.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DYW_deaminase PF14432.6 CDI83170.1 - 5.5 6.9 10.6 9.1 6.2 1.7 2.2 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases SelP_N PF04592.14 CDI83170.1 - 6.3 6.1 26.1 6.5 6.1 9.1 2.1 2 0 0 2 2 2 0 Selenoprotein P, N terminal region MIF4G_like_2 PF09090.11 CDI83170.1 - 6.5 6.1 14.2 4.8 6.6 2.7 2.1 2 0 0 2 2 2 0 MIF4G like CobT PF06213.12 CDI83170.1 - 7 6.0 34.7 3.8 6.8 12.6 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF3306 PF11748.8 CDI83170.1 - 7.7 7.4 19.1 7.4 7.5 4.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) RMP PF14996.6 CDI83170.1 - 7.9 6.7 14.5 9 6.5 3.2 2.1 2 0 0 2 2 2 0 Retinal Maintenance DUF3408 PF11888.8 CDI83170.1 - 8.9 6.5 25.5 11 6.2 8.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Ribosomal_S2 PF00318.20 CDI83170.1 - 9.2 5.4 8.0 11 5.2 0.8 2.1 2 0 0 2 2 2 0 Ribosomal protein S2 Folliculin PF11704.8 CDI83170.1 - 9.3 6.1 17.9 5.3 6.9 4.3 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DnaJ PF00226.31 CDI83174.1 - 1.1e-11 44.6 0.5 8.3e-11 41.9 0.0 2.6 2 1 0 2 2 2 1 DnaJ domain Mis14 PF08641.12 CDI83174.1 - 0.02 15.2 1.2 0.72 10.2 0.9 2.5 2 0 0 2 2 2 0 Kinetochore protein Mis14 like AAA PF00004.29 CDI83175.1 - 3.9e-24 85.6 0.2 3.2e-22 79.4 0.2 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 CDI83175.1 - 1.2e-15 57.3 0.2 1.2e-15 57.3 0.2 1.7 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 CDI83175.1 - 5.9e-07 29.2 0.0 1.8e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 CDI83175.1 - 2.2e-06 27.6 0.1 5.4e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_16 PF13191.6 CDI83175.1 - 0.0042 17.5 0.7 0.26 11.7 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain TPR_12 PF13424.6 CDI83175.1 - 0.013 15.8 0.2 0.032 14.5 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_22 PF13401.6 CDI83175.1 - 0.019 15.2 0.4 0.12 12.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain TPR_5 PF12688.7 CDI83175.1 - 0.067 13.4 0.0 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Tetratrico peptide repeat Diphthami_syn_2 PF01902.17 CDI83176.1 - 3.3e-34 118.3 0.0 1.1e-33 116.6 0.0 1.9 2 1 0 2 2 2 1 Diphthamide synthase Ribosomal_L33 PF00471.20 CDI83178.1 - 6.4e-08 32.9 0.3 6.4e-08 32.9 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L33 DUF5390 PF17365.2 CDI83178.1 - 0.1 12.9 0.5 3.8 7.8 0.0 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5390) DDE_2 PF02914.15 CDI83178.1 - 0.14 11.8 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Mu transposase SH3_2 PF07653.17 CDI83188.1 - 0.048 13.4 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain FTR PF01913.18 CDI83188.1 - 5.4 7.0 7.8 0.12 12.3 0.3 2.2 2 0 0 2 2 2 0 Formylmethanofuran-tetrahydromethanopterin formyltransferase RPA43_OB PF17875.1 CDI83189.1 - 2.4 8.8 5.9 29 5.3 1.7 4.4 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I DUF3040 PF11239.8 CDI83192.1 - 0.82 10.0 4.0 1.1 9.6 4.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) GIT_CC PF16559.5 CDI83192.1 - 7.1 6.6 14.6 8.3 6.4 6.4 2.2 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Rab5ip PF07019.12 CDI83193.1 - 6.1e-10 39.6 6.3 7.8e-06 26.4 2.7 2.0 1 1 1 2 2 2 2 Rab5-interacting protein (Rab5ip) SPATA3 PF15662.5 CDI83194.1 - 0.45 11.1 5.5 1.1 9.9 5.5 1.5 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family SlyX PF04102.12 CDI83194.1 - 2.2 9.0 11.0 0.88 10.2 0.9 2.9 3 0 0 3 3 3 0 SlyX SUIM_assoc PF16619.5 CDI83196.1 - 0.012 15.6 4.8 0.012 15.6 4.8 9.7 8 1 0 8 8 8 0 Unstructured region C-term to UIM in Ataxin3 PH_17 PF18012.1 CDI83196.1 - 0.024 14.3 0.1 0.056 13.2 0.1 1.6 1 0 0 1 1 1 0 PH domain Ntox30 PF15532.6 CDI83196.1 - 1.1 9.6 5.5 1.5 9.2 1.8 3.1 1 1 1 2 2 2 0 Bacterial toxin 30 DUF3105 PF11303.8 CDI83197.1 - 0.092 12.9 0.2 0.17 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) SNF PF00209.18 CDI83198.1 - 5.3e-21 74.9 6.8 4.9e-20 71.7 1.9 2.2 2 0 0 2 2 2 2 Sodium:neurotransmitter symporter family BAF1_ABF1 PF04684.13 CDI83198.1 - 0.52 9.3 0.0 0.52 9.3 0.0 4.9 4 2 0 4 4 4 0 BAF1 / ABF1 chromatin reorganising factor PAP_RNA-bind PF04926.15 CDI83199.1 - 0.16 11.6 1.4 0.41 10.3 1.4 1.8 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain RAP1 PF07218.11 CDI83199.1 - 3.5 5.8 3.6 4.9 5.3 3.6 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Miga PF10265.9 CDI83199.1 - 7.9 5.3 9.1 11 4.8 9.1 1.2 1 0 0 1 1 1 0 Mitoguardin GREB1 PF15782.5 CDI83199.1 - 9.4 3.2 16.7 11 3.0 16.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DHHC PF01529.20 CDI83202.1 - 1.8e-31 109.0 18.1 2e-31 108.8 11.2 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF389 PF04087.14 CDI83202.1 - 0.0021 18.1 0.3 0.6 10.1 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF389) ABC2_membrane_2 PF12679.7 CDI83202.1 - 0.13 11.5 0.1 0.13 11.5 0.1 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein Get5_C PF18514.1 CDI83203.1 - 0.25 11.1 0.3 0.88 9.3 0.3 2.0 1 1 0 1 1 1 0 Get5 C-terminal domain TPR_2 PF07719.17 CDI83204.1 - 0.071 13.3 2.0 0.29 11.4 1.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat VTC PF09359.10 CDI83205.1 - 3e-71 240.1 0.0 7.1e-69 232.3 0.0 2.2 1 1 0 1 1 1 1 VTC domain DUF202 PF02656.15 CDI83205.1 - 1.2e-06 28.8 3.0 1.5e-05 25.3 0.5 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) TMEM52 PF14979.6 CDI83205.1 - 0.58 10.1 2.2 1.3 8.9 0.3 2.2 2 0 0 2 2 2 0 Transmembrane 52 AAA_23 PF13476.6 CDI83208.1 - 0.008 16.7 6.7 0.016 15.7 6.7 1.5 1 0 0 1 1 1 1 AAA domain Utp14 PF04615.13 CDI83208.1 - 0.028 13.0 30.1 0.0031 16.2 12.5 2.2 2 0 0 2 2 2 0 Utp14 protein MAS20 PF02064.15 CDI83208.1 - 3.8 7.6 21.2 2 8.5 5.6 3.8 3 0 0 3 3 3 0 MAS20 protein import receptor OAD_gamma PF04277.13 CDI83208.1 - 8.5 7.0 9.2 9.9 6.8 0.2 4.2 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain Ligase_CoA PF00549.19 CDI83210.1 - 4.8e-19 68.7 1.9 4.8e-19 68.7 1.9 1.6 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_2 PF08442.10 CDI83210.1 - 7.4e-17 61.6 4.8 1.2e-09 38.0 2.0 2.8 1 1 1 2 2 2 2 ATP-grasp domain ATP-grasp_5 PF13549.6 CDI83210.1 - 0.004 16.6 1.5 0.0042 16.6 0.2 1.8 2 0 0 2 2 2 1 ATP-grasp domain Succ_CoA_lig PF13607.6 CDI83210.1 - 0.0077 16.0 0.5 0.014 15.2 0.5 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain Glyoxalase_6 PF18029.1 CDI83210.1 - 0.57 11.0 5.1 0.18 12.6 0.7 2.3 2 1 0 2 2 2 0 Glyoxalase-like domain Phosphoprotein PF00922.17 CDI83214.1 - 0.0019 17.9 2.8 0.0027 17.3 2.8 1.2 1 0 0 1 1 1 1 Vesiculovirus phosphoprotein BSP_II PF05432.11 CDI83214.1 - 4.6 6.9 11.5 6.6 6.3 11.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CBM_14 PF01607.24 CDI83215.1 - 0.084 13.1 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Baculo_VP91_N PF08475.10 CDI83215.1 - 1.2 8.8 5.4 2.2 7.9 5.4 1.3 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal Presenilin PF01080.17 CDI83215.1 - 1.2 7.9 11.4 2.3 6.9 11.4 1.5 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 CDI83215.1 - 1.7 8.5 10.1 0.73 9.7 6.7 1.9 2 0 0 2 2 2 0 SPX domain V_ATPase_I PF01496.19 CDI83215.1 - 2 6.3 9.8 3.3 5.5 9.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RskA PF10099.9 CDI83216.1 - 0.0077 16.5 7.4 0.02 15.2 3.5 2.9 3 0 0 3 3 3 1 Anti-sigma-K factor rskA DUF2681 PF10883.8 CDI83216.1 - 0.027 14.9 0.8 0.027 14.9 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4834 PF16118.5 CDI83216.1 - 0.21 12.6 3.8 8.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 CDI83216.1 - 0.92 8.4 13.4 0.67 8.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF5345 PF17280.2 CDI83216.1 - 1.1 9.3 6.0 5.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Gaa1 PF04114.14 CDI83218.1 - 1.1e-05 24.6 9.7 0.11 11.5 0.3 4.5 5 0 0 5 5 5 3 Gaa1-like, GPI transamidase component Presenilin PF01080.17 CDI83219.1 - 0.021 13.6 12.0 0.24 10.1 0.3 3.1 3 0 0 3 3 3 0 Presenilin Cad PF03596.13 CDI83219.1 - 0.065 13.1 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Cadmium resistance transporter NPR3 PF03666.13 CDI83219.1 - 0.094 11.5 0.0 0.094 11.5 0.0 2.8 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 Spt20 PF12090.8 CDI83219.1 - 0.71 9.4 54.3 0.013 15.1 7.9 3.3 3 0 0 3 3 3 0 Spt20 family DUF4207 PF13904.6 CDI83219.1 - 5.1 6.7 39.1 0.12 12.0 2.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) Questin_oxidase PF14027.6 CDI83220.1 - 0.072 12.6 8.9 0.08 12.5 8.9 1.0 1 0 0 1 1 1 0 Questin oxidase-like Ribosomal_60s PF00428.19 CDI83220.1 - 0.71 10.5 16.2 1.9 9.1 7.2 2.2 1 1 1 2 2 2 0 60s Acidic ribosomal protein Peptidase_M32 PF02074.15 CDI83220.1 - 4.7 5.9 11.0 5.1 5.7 11.0 1.1 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase Dehydrin PF00257.19 CDI83222.1 - 0.013 16.1 0.4 0.013 16.1 0.4 5.2 4 1 1 5 5 5 0 Dehydrin PPP4R2 PF09184.11 CDI83222.1 - 0.4 10.2 8.2 0.83 9.2 8.3 1.5 1 1 0 1 1 1 0 PPP4R2 CNH PF00780.22 CDI83226.1 - 0.016 14.8 2.0 0.019 14.6 2.0 1.1 1 0 0 1 1 1 0 CNH domain RIFIN PF02009.16 CDI83226.1 - 0.15 11.9 14.8 0.21 11.4 14.8 1.3 1 0 0 1 1 1 0 Rifin Sec62 PF03839.16 CDI83226.1 - 1 8.8 4.5 1.3 8.5 4.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 V_ATPase_I PF01496.19 CDI83226.1 - 1 7.2 9.6 1.2 7.0 9.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CDI83226.1 - 1.1 8.0 7.3 1.5 7.5 7.3 1.3 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 CDI83226.1 - 1.2 8.9 4.9 1.5 8.5 4.9 1.1 1 0 0 1 1 1 0 Connexin TFIIA PF03153.13 CDI83226.1 - 1.7 8.6 31.9 2 8.3 31.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI83226.1 - 8.2 5.0 29.5 9 4.8 29.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 CDI83228.1 - 8.7e-05 22.2 16.0 0.00011 21.9 16.0 1.1 1 0 0 1 1 1 1 Spt20 family SSP160 PF06933.11 CDI83228.1 - 0.0023 16.3 14.0 0.0023 16.3 14.0 1.8 2 0 0 2 2 2 1 Special lobe-specific silk protein SSP160 TFIIA PF03153.13 CDI83228.1 - 0.0062 16.6 17.5 0.0072 16.4 17.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF3827 PF12877.7 CDI83228.1 - 0.0093 14.4 6.5 0.011 14.2 6.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) DUF4050 PF13259.6 CDI83228.1 - 0.014 15.8 5.1 0.018 15.4 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF2722 PF10846.8 CDI83228.1 - 0.024 13.6 14.9 0.037 13.0 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Apt1 PF10351.9 CDI83228.1 - 0.034 13.0 7.5 0.037 12.9 7.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 CDI83228.1 - 0.04 13.5 9.3 0.048 13.2 9.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peroxin-3 PF04882.12 CDI83228.1 - 0.046 12.7 7.8 0.051 12.6 7.8 1.1 1 0 0 1 1 1 0 Peroxin-3 MPM1 PF17234.2 CDI83228.1 - 0.048 13.9 8.2 0.067 13.4 8.2 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 SRP-alpha_N PF04086.13 CDI83228.1 - 0.098 12.6 5.9 0.11 12.5 5.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4820 PF16091.5 CDI83228.1 - 0.1 12.0 8.3 0.12 11.7 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Macoilin PF09726.9 CDI83228.1 - 0.11 11.1 12.6 0.14 10.6 12.6 1.2 1 0 0 1 1 1 0 Macoilin family Peptidase_S64 PF08192.11 CDI83228.1 - 0.13 10.7 10.2 0.13 10.7 10.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 RskA PF10099.9 CDI83228.1 - 0.15 12.3 13.0 4.9 7.4 11.5 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA Sporozoite_P67 PF05642.11 CDI83228.1 - 0.22 9.6 7.9 0.26 9.3 7.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SLC12 PF03522.15 CDI83228.1 - 0.23 10.4 6.2 0.25 10.3 6.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Plasmodium_Vir PF05795.11 CDI83228.1 - 0.41 10.0 6.3 0.5 9.7 6.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Presenilin PF01080.17 CDI83228.1 - 0.71 8.6 12.2 0.9 8.2 12.2 1.1 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 CDI83228.1 - 0.72 6.9 13.3 0.78 6.8 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Orf78 PF06024.12 CDI83228.1 - 1.5 9.1 4.9 3.5 8.0 0.6 2.2 2 0 0 2 2 2 0 Orf78 (ac78) XRN_M PF17846.1 CDI83228.1 - 6.8 5.5 6.8 8.7 5.2 6.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain RskA PF10099.9 CDI83230.1 - 0.0057 17.0 11.9 0.0057 17.0 11.9 3.9 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Macoilin PF09726.9 CDI83230.1 - 0.079 11.5 12.5 0.11 11.1 12.5 1.3 1 0 0 1 1 1 0 Macoilin family Otopetrin PF03189.13 CDI83230.1 - 0.2 10.4 0.3 0.27 10.0 0.3 1.4 1 0 0 1 1 1 0 Otopetrin Lin-8 PF03353.15 CDI83230.1 - 0.5 9.9 26.9 0.4 10.2 19.6 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist TCP PF03634.13 CDI83230.1 - 0.73 10.4 19.4 0.038 14.6 8.7 2.9 3 0 0 3 3 3 0 TCP family transcription factor SpoIIP PF07454.11 CDI83230.1 - 4.4 6.7 11.2 6.9 6.0 11.2 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI83230.1 - 6.1 6.6 13.6 78 2.9 14.7 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain MDM10 PF12519.8 CDI83230.1 - 6.5 5.5 9.7 9.7 4.9 9.7 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 SLC12 PF03522.15 CDI83230.1 - 9 5.2 14.8 13 4.7 14.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PAT1 PF09770.9 CDI83230.1 - 9.2 4.4 36.6 14 3.8 36.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NifU PF01106.17 CDI83231.1 - 1.8e-25 88.8 0.1 3.4e-25 88.0 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain DUF2722 PF10846.8 CDI83231.1 - 0.1 11.5 44.4 0.061 12.3 9.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SPX PF03105.19 CDI83231.1 - 0.2 11.5 25.3 0.27 11.1 25.3 1.1 1 0 0 1 1 1 0 SPX domain Utp14 PF04615.13 CDI83231.1 - 0.3 9.6 29.3 0.38 9.3 29.3 1.1 1 0 0 1 1 1 0 Utp14 protein AF-4 PF05110.13 CDI83231.1 - 0.66 8.0 32.1 0.98 7.4 32.1 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF3446 PF11928.8 CDI83231.1 - 2.3 8.6 17.6 0.26 11.6 11.1 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain PAT1 PF09770.9 CDI83231.1 - 5.8 5.0 33.9 8 4.6 33.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PepSY_TM PF03929.16 CDI83233.1 - 2.2 7.9 5.9 2.6 7.6 5.9 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Raftlin PF15250.6 CDI83233.1 - 7.6 5.2 6.4 8.3 5.0 6.4 1.0 1 0 0 1 1 1 0 Raftlin Vfa1 PF08432.10 CDI83233.1 - 7.8 6.8 8.5 9.7 6.5 8.5 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Glyco_transf_20 PF00982.21 CDI83234.1 - 2.8e-23 82.4 0.0 2.8e-23 82.4 0.0 6.4 5 2 3 8 8 8 1 Glycosyltransferase family 20 Med26 PF08711.11 CDI83235.1 - 3.6e-06 26.9 0.1 3.6e-06 26.9 0.1 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain DUF1298 PF06974.13 CDI83236.1 - 6.9e-08 32.6 0.1 0.0088 16.0 0.0 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF1298) SUIM_assoc PF16619.5 CDI83236.1 - 0.0063 16.6 36.0 0.075 13.1 0.6 3.4 3 0 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI83236.1 - 0.0077 15.2 3.4 0.0077 15.2 3.4 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) N6_N4_Mtase PF01555.18 CDI83236.1 - 0.013 15.2 0.2 0.1 12.3 0.3 2.1 2 0 0 2 2 2 0 DNA methylase HSP70 PF00012.20 CDI83237.1 - 6.8e-258 856.8 10.5 7.9e-258 856.6 10.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDI83237.1 - 2.7e-19 69.2 1.9 2.3e-18 66.1 0.8 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Radial_spoke_3 PF06098.11 CDI83237.1 - 0.00048 19.5 0.7 0.00099 18.5 0.7 1.4 1 0 0 1 1 1 1 Radial spoke protein 3 FtsA PF14450.6 CDI83237.1 - 0.00056 20.3 2.6 0.43 11.0 0.1 3.7 3 2 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 CDI83237.1 - 0.012 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 CDI83237.1 - 0.016 14.2 0.5 2.2 7.2 0.2 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain SIKE PF05769.11 CDI83237.1 - 0.074 13.0 0.2 0.074 13.0 0.2 1.8 2 0 0 2 2 2 0 SIKE family DIOX_N PF14226.6 CDI83237.1 - 0.11 13.2 0.0 0.31 11.8 0.0 1.7 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal S1 PF00575.23 CDI83240.1 - 0.0015 18.8 0.1 0.18 12.1 0.4 2.9 3 0 0 3 3 3 1 S1 RNA binding domain DUF966 PF06136.13 CDI83240.1 - 6.7 6.3 21.0 12 5.5 21.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) S1 PF00575.23 CDI83241.1 - 2e-05 24.8 0.0 0.18 12.1 0.0 5.7 6 0 0 6 6 6 1 S1 RNA binding domain FAM221 PF14753.6 CDI83243.1 - 5.6e-06 26.0 2.1 7.6e-06 25.6 2.1 1.3 1 0 0 1 1 1 1 Protein FAM221A/B CLN3 PF02487.17 CDI83243.1 - 0.00035 19.8 3.0 0.00045 19.4 3.0 1.1 1 0 0 1 1 1 1 CLN3 protein TFB6 PF17110.5 CDI83243.1 - 0.0022 17.7 0.3 0.0031 17.3 0.3 1.2 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH RskA PF10099.9 CDI83243.1 - 0.0044 17.3 16.0 0.0044 17.3 16.0 2.6 1 1 1 2 2 1 1 Anti-sigma-K factor rskA PAT1 PF09770.9 CDI83243.1 - 0.0053 15.1 18.3 0.0053 15.1 18.3 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI83243.1 - 0.026 14.5 32.4 0.036 14.1 32.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 CDI83243.1 - 0.051 12.6 8.3 0.058 12.4 8.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TCP PF03634.13 CDI83243.1 - 0.055 14.0 10.8 0.08 13.5 10.8 1.3 1 0 0 1 1 1 0 TCP family transcription factor DUF3112 PF11309.8 CDI83243.1 - 0.075 12.5 1.2 0.092 12.2 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Connexin PF00029.19 CDI83243.1 - 0.077 12.8 6.5 0.1 12.4 6.5 1.1 1 0 0 1 1 1 0 Connexin CRT10 PF08728.10 CDI83243.1 - 0.094 10.9 3.7 0.11 10.7 3.7 1.0 1 0 0 1 1 1 0 CRT10 CPSF100_C PF13299.6 CDI83243.1 - 0.11 12.7 9.3 0.032 14.4 6.5 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SID-1_RNA_chan PF13965.6 CDI83243.1 - 0.11 10.8 1.3 0.13 10.7 1.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Pex14_N PF04695.13 CDI83243.1 - 0.14 12.9 25.0 0.065 13.9 20.5 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CSG2 PF16965.5 CDI83243.1 - 0.21 10.5 2.2 0.25 10.2 2.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator SpoIIP PF07454.11 CDI83243.1 - 0.47 9.9 12.0 0.63 9.5 12.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spore_coat_CotO PF14153.6 CDI83243.1 - 0.47 10.3 20.7 0.74 9.7 20.7 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Presenilin PF01080.17 CDI83243.1 - 0.67 8.7 14.7 0.9 8.2 14.7 1.2 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 CDI83243.1 - 0.77 6.8 12.9 0.79 6.8 12.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 CDI83243.1 - 0.84 9.6 8.8 1.1 9.3 8.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.6 CDI83243.1 - 0.98 9.4 9.4 1.4 8.9 9.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF4366 PF14283.6 CDI83243.1 - 1 9.4 10.2 0.29 11.2 6.8 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Peptidase_U57 PF05582.12 CDI83243.1 - 1.1 8.5 6.4 1.5 8.0 6.4 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Ribonuc_P_40 PF08584.11 CDI83243.1 - 1.1 8.5 8.0 1.4 8.2 8.0 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit NEMP PF10225.9 CDI83243.1 - 1.1 8.9 3.9 1.4 8.6 3.9 1.2 1 0 0 1 1 1 0 NEMP family PIP5K PF01504.18 CDI83243.1 - 1.1 8.4 10.4 1.5 8.0 10.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Pannexin_like PF12534.8 CDI83243.1 - 1.2 8.1 9.6 1.6 7.8 9.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Band_3_cyto PF07565.13 CDI83243.1 - 1.5 8.6 11.6 2 8.2 11.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Med26_C PF15693.5 CDI83243.1 - 1.5 8.9 16.8 2.1 8.4 16.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal Baculo_PP31 PF05311.11 CDI83243.1 - 1.5 8.2 11.7 2.1 7.8 11.7 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) eIF-3_zeta PF05091.12 CDI83243.1 - 1.7 7.6 15.7 2.1 7.2 15.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DAG_kinase_N PF14513.6 CDI83243.1 - 2.1 8.5 15.2 3.2 7.9 15.2 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Gti1_Pac2 PF09729.9 CDI83243.1 - 2.2 8.3 10.6 3.4 7.7 10.6 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Cellulose_synt PF03552.14 CDI83243.1 - 2.3 6.6 3.7 2.8 6.3 3.7 1.0 1 0 0 1 1 1 0 Cellulose synthase Hid1 PF12722.7 CDI83243.1 - 2.3 6.2 10.4 2.7 6.0 10.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sec62 PF03839.16 CDI83243.1 - 2.8 7.4 10.2 3.8 7.0 10.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Membralin PF09746.9 CDI83243.1 - 2.9 6.9 6.7 3.5 6.6 6.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein Lin-8 PF03353.15 CDI83243.1 - 3.1 7.3 18.2 4.5 6.7 18.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ctr PF04145.15 CDI83243.1 - 3.2 8.3 13.2 5.3 7.6 13.2 1.4 1 1 0 1 1 1 0 Ctr copper transporter family Paramyxo_ncap PF00973.19 CDI83243.1 - 3.4 6.5 8.0 4.3 6.1 8.0 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Nop53 PF07767.11 CDI83243.1 - 3.5 6.9 19.7 4.8 6.5 19.7 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) EMC3_TMCO1 PF01956.16 CDI83243.1 - 3.6 7.3 11.3 4.9 6.8 11.3 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RR_TM4-6 PF06459.12 CDI83243.1 - 4.4 7.0 13.6 6.3 6.5 13.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 O-antigen_lig PF13425.6 CDI83243.1 - 4.6 5.9 4.5 5.6 5.6 4.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4820 PF16091.5 CDI83243.1 - 6.6 6.0 15.6 3.4 7.0 6.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) DUF2828 PF11443.8 CDI83243.1 - 9.8 4.1 13.1 13 3.8 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MKT1_C PF12246.8 CDI83244.1 - 2e-49 168.0 0.5 3.5e-49 167.2 0.0 1.6 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 CDI83244.1 - 5.1e-09 36.5 0.0 1.8e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CDI83244.1 - 3e-05 24.3 0.2 0.00011 22.5 0.0 2.2 2 0 0 2 2 2 1 XPG I-region TFIIA PF03153.13 CDI83244.1 - 0.00016 21.8 19.6 0.00016 21.8 19.6 3.3 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI83244.1 - 0.00073 20.2 16.7 0.00073 20.2 16.7 4.2 4 0 0 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SpoIIP PF07454.11 CDI83244.1 - 5.3 6.4 16.3 0.038 13.4 6.1 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Miga PF10265.9 CDI83244.1 - 5.4 5.9 17.9 1.8 7.5 7.8 2.9 2 0 0 2 2 2 0 Mitoguardin ExbD PF02472.16 CDI83244.1 - 6.6 6.9 7.2 25 5.1 6.8 2.1 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR PGA_cap PF09587.10 CDI83244.1 - 7.7 5.9 6.8 1.1 8.7 2.3 1.9 2 0 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap PKD_channel PF08016.12 CDI83245.1 - 7e-12 44.8 30.5 1.6e-08 33.7 9.5 3.8 4 0 0 4 4 4 2 Polycystin cation channel Cullin PF00888.22 CDI83246.1 - 6e-129 431.4 6.2 2.6e-66 224.5 0.0 2.0 2 0 0 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 CDI83246.1 - 7.9e-22 77.1 0.6 2.6e-21 75.4 0.4 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF445 PF04286.12 CDI83246.1 - 1.3 8.8 4.6 1.3 8.8 1.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF445) AgrB PF04647.15 CDI83249.1 - 0.096 12.0 1.8 0.17 11.2 1.8 1.4 1 0 0 1 1 1 0 Accessory gene regulator B DUF4692 PF15763.5 CDI83249.1 - 0.13 12.7 4.2 0.24 11.9 4.2 1.3 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Tam41_Mmp37 PF09139.11 CDI83250.1 - 7.2e-28 98.0 0.0 1.3e-12 47.8 0.0 3.6 4 1 0 4 4 4 3 Phosphatidate cytidylyltransferase, mitochondrial ACBP PF00887.19 CDI83251.1 - 6.3e-20 71.2 0.5 6.3e-20 71.2 0.5 2.7 2 0 0 2 2 2 1 Acyl CoA binding protein TFIIA PF03153.13 CDI83251.1 - 0.01 15.9 21.5 0.01 15.9 21.5 3.1 2 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI83251.1 - 0.047 13.3 84.9 0.14 11.8 25.2 3.5 3 0 0 3 3 3 0 Spt20 family DUF2828 PF11443.8 CDI83251.1 - 0.087 10.9 25.2 0.012 13.7 5.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Med15 PF09606.10 CDI83251.1 - 1.3 7.6 79.0 0.74 8.4 20.6 2.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SpoIIP PF07454.11 CDI83251.1 - 2.1 7.7 30.2 1.5 8.3 1.0 3.2 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 CDI83251.1 - 3.1 5.9 63.4 0.52 8.5 17.6 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 AAA PF00004.29 CDI83252.1 - 4e-42 143.8 0.0 4.1e-36 124.3 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 CDI83252.1 - 1.2e-15 57.6 0.0 3.1e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal IstB_IS21 PF01695.17 CDI83252.1 - 2.6e-05 24.0 0.1 0.00025 20.8 0.0 2.4 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_16 PF13191.6 CDI83252.1 - 0.00016 22.1 6.1 0.35 11.2 0.0 4.5 3 1 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 CDI83252.1 - 0.0019 18.4 0.0 0.016 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 CDI83252.1 - 0.031 14.2 0.2 6.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain RNA_helicase PF00910.22 CDI83252.1 - 0.032 14.6 0.0 9.7 6.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 CDI83252.1 - 0.064 13.5 4.2 1.3 9.3 0.1 3.7 3 1 1 4 4 4 0 AAA domain AAA_5 PF07728.14 CDI83252.1 - 0.2 11.7 2.8 0.57 10.2 0.2 3.1 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CDI83252.1 - 0.95 9.7 3.4 1.7 8.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain TSP9 PF11493.8 CDI83253.1 - 0.22 12.2 2.3 0.89 10.3 0.3 2.9 2 1 1 3 3 3 0 Thylakoid soluble phosphoprotein TSP9 Arm PF00514.23 CDI83254.1 - 5.8e-07 29.3 13.7 0.19 11.8 0.0 9.0 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CDI83254.1 - 0.051 14.0 12.0 0.11 12.9 0.2 6.0 4 1 0 4 4 4 0 HEAT repeats ThiF PF00899.21 CDI83255.1 - 2.9e-44 151.3 0.5 6.2e-44 150.2 0.5 1.5 1 1 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CDI83255.1 - 0.00091 19.5 0.1 1.8 8.9 0.0 2.5 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDI83255.1 - 0.015 15.7 0.3 0.078 13.4 0.3 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CDI83255.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Cpn10 PF00166.21 CDI83256.1 - 1.2e-15 57.3 0.0 1.5e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cas_csx3 PF09620.10 CDI83256.1 - 0.062 13.2 0.1 0.1 12.5 0.1 1.4 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) HU-CCDC81_bac_1 PF18174.1 CDI83256.1 - 0.15 11.9 0.0 6.4 6.7 0.0 2.2 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 RPAP2_Rtr1 PF04181.13 CDI83257.1 - 1.1e-07 32.1 1.6 1.1e-07 32.1 1.6 2.4 3 0 0 3 3 3 1 Rtr1/RPAP2 family TPH PF13868.6 CDI83258.1 - 1.7e-23 82.8 100.7 1.7e-23 82.8 100.7 2.5 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain Ank_2 PF12796.7 CDI83260.1 - 3.4e-36 123.7 0.0 1.4e-14 54.4 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDI83260.1 - 1.2e-30 105.4 0.3 3.4e-13 49.8 0.0 5.5 2 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 CDI83260.1 - 2.1e-25 88.0 4.7 6.3e-05 23.2 0.0 7.6 7 1 1 8 8 8 5 Ankyrin repeat Ank_3 PF13606.6 CDI83260.1 - 1.1e-24 83.8 0.6 0.0027 18.1 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 CDI83260.1 - 1.5e-22 79.4 0.9 1.3e-05 25.4 0.0 6.2 3 1 4 7 7 7 5 Ankyrin repeats (many copies) Nrap_D4 PF17405.2 CDI83262.1 - 2.2e-25 89.3 0.4 4.1e-25 88.4 0.4 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 CDI83262.1 - 1.4e-16 60.9 0.0 9.9e-16 58.2 0.0 2.4 3 0 0 3 3 3 1 Nrap protein domain 3 Nrap_D5 PF17406.2 CDI83262.1 - 3.7e-16 59.3 0.0 2.2e-15 56.8 0.0 2.3 2 1 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 CDI83262.1 - 6.4e-14 52.3 0.2 2.4e-13 50.4 0.2 1.9 1 1 0 1 1 1 1 Nrap protein domain 1 Nrap_D2 PF17403.2 CDI83262.1 - 3.5e-10 39.8 0.1 8e-08 32.2 0.0 3.3 2 1 0 2 2 2 1 Nrap protein PAP/OAS-like domain RNase_H2-Ydr279 PF09468.10 CDI83263.1 - 0.0022 18.2 0.1 0.0039 17.4 0.1 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain NIF PF03031.18 CDI83264.1 - 2.9e-17 62.8 0.0 4.2e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Myb_DNA-binding PF00249.31 CDI83267.1 - 1.1e-10 41.5 0.0 3.3e-10 40.0 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 CDI83267.1 - 1.1e-09 38.0 7.9 2e-09 37.1 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 CDI83267.1 - 1.2e-06 28.6 0.0 7.2e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF2722 PF10846.8 CDI83267.1 - 0.00075 18.6 1.5 0.00075 18.6 1.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) C1_2 PF03107.16 CDI83267.1 - 0.0011 19.2 5.3 0.0023 18.2 5.3 1.5 1 0 0 1 1 1 1 C1 domain Spt20 PF12090.8 CDI83267.1 - 0.0017 18.0 2.8 0.0017 18.0 2.8 1.9 2 0 0 2 2 2 1 Spt20 family ESM4 PF15952.5 CDI83267.1 - 0.034 14.6 2.7 3.8 7.9 0.2 2.5 2 0 0 2 2 2 0 Enhancer of split M4 family SUIM_assoc PF16619.5 CDI83267.1 - 0.25 11.5 16.3 1.3 9.1 10.3 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Roughex PF06020.11 CDI83267.1 - 4.2 6.4 8.5 0.76 8.8 4.0 1.9 2 0 0 2 2 2 0 Drosophila roughex protein MarR PF01047.22 CDI83270.1 - 0.07 13.1 0.1 0.28 11.1 0.1 2.0 1 0 0 1 1 1 0 MarR family SR-25 PF10500.9 CDI83271.1 - 0.0017 18.0 17.4 0.0017 18.0 17.4 12.2 9 2 2 11 11 11 1 Nuclear RNA-splicing-associated protein Adaptin_binding PF10199.9 CDI83271.1 - 0.023 15.3 0.0 0.023 15.3 0.0 10.9 8 3 0 8 8 8 0 Alpha and gamma adaptin binding protein p34 RskA PF10099.9 CDI83271.1 - 0.36 11.1 0.0 0.36 11.1 0.0 23.7 10 5 9 20 20 20 0 Anti-sigma-K factor rskA DUF4667 PF15700.5 CDI83272.1 - 0.0054 16.9 7.7 0.0054 16.9 7.7 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4667) Velvet PF11754.8 CDI83272.1 - 0.15 12.0 9.4 0.22 11.5 1.0 3.1 3 0 0 3 3 3 0 Velvet factor DUF4050 PF13259.6 CDI83272.1 - 0.83 10.0 12.4 3.2 8.1 3.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4050) S-AdoMet_synt_C PF02773.16 CDI83273.1 - 5.6e-63 211.0 0.1 1.5e-62 209.6 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDI83273.1 - 1.6e-45 154.3 0.0 3.1e-45 153.3 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CDI83273.1 - 1.2e-43 147.8 0.3 2.5e-43 146.8 0.3 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain FAD_binding_4 PF01565.23 CDI83274.1 - 1.2e-34 119.1 0.1 1.9e-34 118.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF3626 PF12294.8 CDI83275.1 - 1.5e-09 37.4 0.0 4.6e-09 35.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3626) SET PF00856.28 CDI83276.1 - 0.023 15.1 0.2 0.064 13.7 0.2 1.8 1 0 0 1 1 1 0 SET domain TPR_16 PF13432.6 CDI83276.1 - 1.1 10.0 5.2 4.4 8.1 5.2 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat PDEase_I PF00233.19 CDI83277.1 - 2.5e-49 168.2 0.1 5.2e-49 167.1 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase RskA PF10099.9 CDI83277.1 - 0.05 13.9 10.0 0.13 12.6 10.0 1.6 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF2203 PF09969.9 CDI83277.1 - 0.074 13.8 0.2 2.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) HD PF01966.22 CDI83277.1 - 0.17 12.1 0.1 0.51 10.6 0.1 1.7 1 0 0 1 1 1 0 HD domain GED PF02212.18 CDI83277.1 - 5.2 7.3 6.0 0.72 10.0 0.2 2.3 2 0 0 2 2 2 0 Dynamin GTPase effector domain TFIIF_alpha PF05793.12 CDI83278.1 - 0.032 12.8 10.6 0.043 12.4 9.1 1.7 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Clat_adaptor_s PF01217.20 CDI83279.1 - 3.2e-17 62.8 1.7 3.7e-17 62.6 1.7 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Myb_DNA-binding PF00249.31 CDI83280.1 - 0.021 15.0 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Abhydrolase_3 PF07859.13 CDI83282.1 - 3.5e-26 92.4 0.0 3.5e-26 92.4 0.0 3.9 3 1 1 4 4 4 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CDI83282.1 - 1.4e-14 53.8 0.0 1.4e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 Steryl acetyl hydrolase SpoIIP PF07454.11 CDI83282.1 - 0.0058 16.1 0.8 0.0058 16.1 0.8 2.9 3 1 0 3 3 3 1 Stage II sporulation protein P (SpoIIP) Peptidase_S9 PF00326.21 CDI83282.1 - 0.034 13.6 0.0 0.034 13.6 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ribosomal_S2 PF00318.20 CDI83282.1 - 0.098 11.9 1.2 0.23 10.6 1.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S2 Connexin PF00029.19 CDI83282.1 - 0.72 9.6 7.4 0.34 10.6 3.6 2.2 2 0 0 2 2 2 0 Connexin DUF4770 PF15994.5 CDI83282.1 - 0.78 10.0 12.0 0.28 11.4 7.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF3675 PF12428.8 CDI83282.1 - 0.85 10.2 2.2 12 6.5 2.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) DUF4638 PF15472.6 CDI83282.1 - 3.1 7.5 9.4 0.83 9.3 5.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) TFIIA PF03153.13 CDI83283.1 - 0.0044 17.1 26.7 0.0044 17.1 26.7 6.1 3 2 1 5 5 5 2 Transcription factor IIA, alpha/beta subunit MRP-S31 PF15433.6 CDI83284.1 - 0.011 15.5 6.4 0.022 14.4 6.4 1.6 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 TetR_N PF00440.23 CDI83284.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family DDHD PF02862.17 CDI83284.1 - 0.16 12.1 1.5 0.23 11.6 1.5 1.3 1 0 0 1 1 1 0 DDHD domain Use1 PF09753.9 CDI83284.1 - 0.65 9.7 9.5 1 9.0 9.5 1.5 1 1 0 1 1 1 0 Membrane fusion protein Use1 GOLD_2 PF13897.6 CDI83284.1 - 7.6 7.0 12.5 0.11 13.0 1.2 2.7 1 1 2 3 3 3 0 Golgi-dynamics membrane-trafficking HA2 PF04408.23 CDI83285.1 - 6.2e-19 68.3 4.5 4e-18 65.7 0.0 3.7 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDI83285.1 - 8.9e-18 64.4 0.0 1.9e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDI83285.1 - 2.8e-12 46.9 0.0 6.3e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI83285.1 - 2.3e-05 24.2 0.9 0.00012 21.9 0.9 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDI83285.1 - 0.00097 19.4 0.1 0.0062 16.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDI83285.1 - 0.0027 16.8 0.0 0.0099 15.0 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.6 CDI83285.1 - 0.12 12.4 0.0 24 5.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDI83285.1 - 0.82 10.1 0.0 0.82 10.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 CDI83285.1 - 1.8 8.9 6.2 0.4 11.0 1.0 2.5 2 1 0 2 2 2 0 AAA domain TPR_19 PF14559.6 CDI83286.1 - 5.7e-09 36.4 1.5 7.7e-06 26.3 0.0 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDI83286.1 - 0.00073 19.4 3.0 0.64 10.2 0.0 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI83286.1 - 0.0013 18.5 0.1 24 5.0 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDI83286.1 - 0.0057 16.8 0.1 7.3 7.1 0.0 4.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDI83286.1 - 0.017 15.2 10.1 1.4 9.2 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDI83286.1 - 0.087 13.7 0.0 0.087 13.7 0.0 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI83286.1 - 0.14 12.4 0.0 0.14 12.4 0.0 3.0 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Nterm_IS4 PF13006.7 CDI83286.1 - 0.21 11.8 0.0 0.21 11.8 0.0 2.6 4 0 0 4 4 4 0 Insertion element 4 transposase N-terminal Syntaxin-6_N PF09177.11 CDI83286.1 - 0.34 11.5 0.1 0.34 11.5 0.1 3.1 3 2 0 3 3 3 0 Syntaxin 6, N-terminal Ndc1_Nup PF09531.10 CDI83286.1 - 0.42 9.2 7.6 0.032 12.9 2.3 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup YabA PF06156.13 CDI83286.1 - 0.8 10.4 7.8 1.9 9.1 3.7 2.8 3 1 0 3 3 3 0 Initiation control protein YabA TPR_9 PF13371.6 CDI83286.1 - 1.5 9.0 0.0 1.5 9.0 0.0 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Roughex PF06020.11 CDI83286.1 - 1.7 7.7 11.4 6 5.9 0.4 2.1 2 0 0 2 2 2 0 Drosophila roughex protein Dehydrin PF00257.19 CDI83286.1 - 2.4 8.7 6.6 0.7 10.4 3.4 1.7 2 0 0 2 2 2 0 Dehydrin SPX PF03105.19 CDI83287.1 - 0.0072 16.3 4.2 0.0072 16.3 4.2 2.9 2 1 0 2 2 2 1 SPX domain DUF4614 PF15391.6 CDI83287.1 - 2.5 8.0 13.3 0.063 13.3 3.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) TFIIA PF03153.13 CDI83287.1 - 9.4 6.1 40.1 0.036 14.1 2.2 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit API5 PF05918.11 CDI83288.1 - 0.18 10.6 5.8 0.36 9.6 5.8 1.5 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF908 PF06012.12 CDI83288.1 - 1.1 8.6 18.3 1.6 8.1 4.4 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Apt1 PF10351.9 CDI83288.1 - 8.9 5.0 26.0 7 5.4 15.6 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF3446 PF11928.8 CDI83289.1 - 0.0016 18.7 6.9 0.0016 18.7 6.9 12.7 6 3 2 11 11 11 1 Early growth response N-terminal domain MDM31_MDM32 PF08118.11 CDI83289.1 - 0.65 8.6 2.4 1.7 7.2 2.4 1.6 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Het-C PF07217.11 CDI83289.1 - 1.1 7.7 8.0 2.9 6.3 8.0 1.6 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF1218 PF06749.12 CDI83292.1 - 0.026 15.0 4.0 0.026 15.0 4.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) DUF202 PF02656.15 CDI83292.1 - 1.7 9.2 0.0 1.7 9.2 0.0 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF202) RRM_1 PF00076.22 CDI83293.1 - 1.3e-16 60.1 0.0 1.3e-07 31.4 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 CDI83293.1 - 0.35 10.8 21.5 0.016 15.2 13.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI83293.1 - 1 9.1 9.4 1.6 8.5 9.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CDI83293.1 - 1.5 9.0 8.4 2.4 8.2 8.4 1.3 1 0 0 1 1 1 0 DDHD domain Peptidase_S64 PF08192.11 CDI83293.1 - 9.4 4.6 12.4 12 4.2 12.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Macoilin PF09726.9 CDI83294.1 - 1 7.8 6.6 1.5 7.3 6.6 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 CDI83294.1 - 1.1 9.1 21.0 1.6 8.6 21.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ubiquitin PF00240.23 CDI83295.1 - 1.4e-20 72.8 0.1 2.9e-20 71.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDI83295.1 - 1.2e-06 28.2 0.0 2.5e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 CDI83295.1 - 3.8e-05 23.5 0.1 7.9e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain HOIP-UBA PF16678.5 CDI83295.1 - 0.00012 22.1 1.3 0.012 15.6 0.0 2.6 2 0 0 2 2 2 1 HOIP UBA domain pair Rad60-SLD_2 PF13881.6 CDI83295.1 - 0.00018 21.6 0.9 0.00018 21.6 0.9 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CDI83295.1 - 0.00087 19.8 0.6 0.00087 19.8 0.6 1.6 2 0 0 2 2 1 1 DUF2407 ubiquitin-like domain SUIM_assoc PF16619.5 CDI83295.1 - 0.0029 17.6 6.6 0.0029 17.6 6.6 2.5 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 CUE PF02845.16 CDI83295.1 - 0.004 16.8 0.0 0.011 15.4 0.0 1.8 1 0 0 1 1 1 1 CUE domain Ubiquitin_2 PF14560.6 CDI83295.1 - 0.0059 17.0 0.1 0.013 15.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDI83295.1 - 0.017 15.0 0.0 0.017 15.0 0.0 1.7 2 0 0 2 2 1 0 TANK binding kinase 1 ubiquitin-like domain UBA_4 PF14555.6 CDI83295.1 - 0.067 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain DUF2722 PF10846.8 CDI83295.1 - 3.8 6.4 14.3 0.54 9.1 9.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI83295.1 - 5.1 6.6 20.2 0.61 9.7 13.6 2.1 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI83295.1 - 8.3 6.3 26.0 6.7 6.6 16.6 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 CDI83295.1 - 8.4 5.4 10.7 0.042 12.9 1.8 1.6 2 0 0 2 2 2 0 Drosophila roughex protein Peptidase_M3 PF01432.20 CDI83296.1 - 3.7e-11 42.9 0.0 1.8e-09 37.4 0.0 2.9 1 1 0 1 1 1 1 Peptidase family M3 SUIM_assoc PF16619.5 CDI83296.1 - 0.014 15.5 0.0 0.05 13.7 0.0 1.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF1908 PF08926.11 CDI83296.1 - 0.058 12.5 2.0 0.084 11.9 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) DUF3632 PF12311.8 CDI83296.1 - 0.069 13.6 3.7 0.15 12.5 3.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3632) Ribosomal_60s PF00428.19 CDI83296.1 - 8.6 7.0 15.9 0.85 10.3 4.8 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein MFS_2 PF13347.6 CDI83297.1 - 0.002 16.7 1.4 0.0023 16.5 1.4 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Kinase-like PF14531.6 CDI83299.1 - 5.5e-07 29.2 0.0 1.3e-06 28.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.25 CDI83299.1 - 0.033 13.6 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 CDI83301.1 - 1.2e-05 24.8 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI83301.1 - 0.00011 21.6 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI83302.1 - 1.7e-16 60.4 0.0 8.7e-13 48.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83302.1 - 1.4e-06 27.8 0.0 8.3e-06 25.3 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI83302.1 - 1.3e-05 24.7 0.1 0.00018 21.0 0.1 2.4 2 1 0 2 2 2 1 Kinase-like Solute_trans_a PF03619.16 CDI83303.1 - 6.9e-18 65.1 1.3 6.4e-10 39.0 0.1 2.2 2 0 0 2 2 2 2 Organic solute transporter Ostalpha Pro_isomerase PF00160.21 CDI83305.1 - 2.3e-20 73.4 0.0 3e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF2722 PF10846.8 CDI83307.1 - 0.0016 17.5 7.3 0.0021 17.1 7.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) SMYLE_N PF18615.1 CDI83307.1 - 0.014 15.0 5.9 0.022 14.4 5.9 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PAT1 PF09770.9 CDI83307.1 - 0.045 12.0 14.9 0.048 11.9 14.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 CDI83307.1 - 0.047 13.1 7.9 0.061 12.8 6.9 1.8 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) MMR1 PF08505.10 CDI83307.1 - 0.068 13.4 8.2 0.12 12.6 8.2 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4770 PF15994.5 CDI83307.1 - 0.091 13.0 5.8 0.16 12.2 5.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RR_TM4-6 PF06459.12 CDI83307.1 - 0.2 11.5 17.9 0.29 10.9 17.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 CDI83307.1 - 0.22 10.9 9.2 0.44 9.9 9.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SOBP PF15279.6 CDI83307.1 - 0.24 12.0 9.8 0.31 11.6 9.8 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein LMBR1 PF04791.16 CDI83307.1 - 0.25 10.2 1.7 0.34 9.7 1.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein eIF-3_zeta PF05091.12 CDI83307.1 - 0.35 9.8 10.8 0.45 9.4 10.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PMSI1 PF15322.6 CDI83307.1 - 0.55 9.6 13.3 0.89 8.9 13.3 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative DUF3408 PF11888.8 CDI83307.1 - 0.72 10.0 13.0 1.6 8.9 13.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) FAM60A PF15396.6 CDI83307.1 - 0.76 9.7 8.1 1.1 9.2 8.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A GREB1 PF15782.5 CDI83307.1 - 1.2 6.2 13.6 1.5 5.9 13.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Raftlin PF15250.6 CDI83307.1 - 1.5 7.5 11.3 2 7.1 11.3 1.2 1 0 0 1 1 1 0 Raftlin DUF1764 PF08576.10 CDI83307.1 - 1.8 9.5 11.6 21 6.1 13.0 2.1 2 1 0 2 2 1 0 Eukaryotic protein of unknown function (DUF1764) CCSAP PF15748.5 CDI83307.1 - 1.9 8.6 16.2 3.3 7.8 16.2 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Neur_chan_memb PF02932.16 CDI83307.1 - 2.1 8.3 7.2 3.7 7.5 7.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 CDI83307.1 - 2.3 7.1 10.6 3.8 6.3 10.6 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4834 PF16118.5 CDI83307.1 - 2.3 9.2 9.2 4.8 8.2 9.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 CDI83307.1 - 3.6 6.5 5.9 5 6.1 5.9 1.3 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 CDI83307.1 - 4.7 6.1 14.0 6.7 5.6 14.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 CDI83307.1 - 5.8 5.6 13.7 8.2 5.1 13.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Baculo_PP31 PF05311.11 CDI83307.1 - 6.6 6.1 12.7 10 5.5 12.7 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Presenilin PF01080.17 CDI83307.1 - 7.3 5.2 17.1 9.9 4.8 17.1 1.1 1 0 0 1 1 1 0 Presenilin MIF4G PF02854.19 CDI83308.1 - 1.4e-33 116.3 0.9 1.4e-33 116.3 0.9 2.2 2 0 0 2 2 2 1 MIF4G domain Peptidase_C48 PF02902.19 CDI83309.1 - 1.5e-15 57.6 10.4 1e-10 41.9 1.9 3.5 3 1 0 3 3 3 2 Ulp1 protease family, C-terminal catalytic domain TFIIA PF03153.13 CDI83309.1 - 0.00043 20.4 13.4 0.00043 20.4 13.4 4.0 4 0 0 4 4 4 2 Transcription factor IIA, alpha/beta subunit DUF4413 PF14372.6 CDI83309.1 - 0.081 13.3 1.0 2.1 8.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) Pex16 PF08610.10 CDI83309.1 - 0.31 10.1 9.3 0.051 12.7 1.2 2.8 3 0 0 3 3 3 0 Peroxisomal membrane protein (Pex16) Plasmodium_Vir PF05795.11 CDI83309.1 - 5.9 6.2 10.5 1.5 8.1 2.6 2.7 2 1 0 2 2 2 0 Plasmodium vivax Vir protein Glt_symporter PF03616.14 CDI83309.1 - 9.9 4.7 10.5 0.068 11.8 0.6 2.0 2 0 0 2 2 2 0 Sodium/glutamate symporter Pkinase PF00069.25 CDI83310.1 - 2.2e-41 142.0 0.0 4.1e-41 141.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83310.1 - 1e-18 67.6 0.0 1.7e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NUDIX_2 PF13869.6 CDI83311.1 - 3.5e-57 193.0 0.0 4.4e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase DUF667 PF05018.13 CDI83312.1 - 2.1e-10 40.7 0.0 2.7e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) WD40 PF00400.32 CDI83313.1 - 0.7 10.9 8.3 1.4e+02 3.5 0.1 6.1 7 0 0 7 7 7 0 WD domain, G-beta repeat Kelch_4 PF13418.6 CDI83314.1 - 1e-13 51.1 4.7 2.6e-06 27.4 0.1 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI83314.1 - 1.5e-10 40.9 3.9 0.00048 20.3 0.1 4.3 2 1 2 4 4 4 2 Kelch motif Kelch_5 PF13854.6 CDI83314.1 - 6.2e-10 38.8 3.1 0.00017 21.5 0.1 3.3 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 CDI83314.1 - 1.5e-07 31.1 4.1 0.0025 17.7 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 CDI83314.1 - 7.3e-07 28.7 10.5 1.5e-05 24.5 0.1 4.1 3 1 1 4 4 4 3 Kelch motif Kelch_3 PF13415.6 CDI83314.1 - 0.0002 21.6 8.4 14 6.1 0.0 4.8 4 1 0 4 4 4 3 Galactose oxidase, central domain Peptidase_M22 PF00814.25 CDI83315.1 - 1.6e-72 244.4 0.2 5.8e-54 183.6 0.2 2.2 1 1 0 2 2 2 2 Glycoprotease family DUF2161 PF09929.9 CDI83315.1 - 0.4 10.8 2.0 1 9.5 2.0 1.7 1 1 0 1 1 1 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Laminin_G_3 PF13385.6 CDI83319.1 - 3.9e-12 46.6 0.0 0.00097 19.3 0.0 4.7 5 0 0 5 5 5 3 Concanavalin A-like lectin/glucanases superfamily Phos_pyr_kin PF08543.12 CDI83319.1 - 2e-07 30.6 1.4 7e-07 28.9 0.0 2.6 3 0 0 3 3 3 1 Phosphomethylpyrimidine kinase CLTH PF10607.9 CDI83322.1 - 7.2e-10 38.9 0.0 2.8e-09 37.0 0.0 1.8 1 1 1 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain YfdX PF10938.8 CDI83322.1 - 0.044 13.7 0.5 3.1 7.7 0.1 2.5 2 0 0 2 2 2 0 YfdX protein DUF2192 PF09958.9 CDI83322.1 - 0.059 12.9 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) Peptidase_S64 PF08192.11 CDI83322.1 - 0.11 11.0 3.1 0.15 10.5 3.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 Hamartin PF04388.12 CDI83322.1 - 0.24 10.0 13.7 0.27 9.9 13.7 1.1 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 CDI83322.1 - 1 8.5 25.3 1.5 8.0 25.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Presenilin PF01080.17 CDI83322.1 - 3.1 6.4 4.3 4.2 6.0 4.3 1.3 1 0 0 1 1 1 0 Presenilin SMK-1 PF04802.15 CDI83323.1 - 1.3e-09 38.1 2.7 7.4e-07 29.2 0.5 3.3 3 0 0 3 3 3 2 Component of IIS longevity pathway SMK-1 RNA_pol_3_Rpc31 PF11705.8 CDI83323.1 - 0.00021 21.7 11.7 0.00021 21.7 11.7 4.5 4 0 0 4 4 4 2 DNA-directed RNA polymerase III subunit Rpc31 SR-25 PF10500.9 CDI83323.1 - 0.0019 17.8 6.0 0.0019 17.8 6.0 11.7 9 3 1 11 11 11 2 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 CDI83323.1 - 0.0025 16.7 1.8 0.0025 16.7 1.8 7.5 6 1 2 8 8 8 2 Presenilin SR-25 PF10500.9 CDI83324.1 - 0.06 12.9 13.8 0.065 12.8 13.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sld5 PF05916.11 CDI83325.1 - 0.0027 18.1 0.1 0.0062 17.0 0.1 1.6 1 0 0 1 1 1 1 GINS complex protein XRN_M PF17846.1 CDI83327.1 - 1.4e-36 126.4 0.7 3.1e-28 98.9 1.0 5.8 3 1 2 6 6 6 3 Xrn1 helical domain DUF2722 PF10846.8 CDI83327.1 - 0.0043 16.1 4.5 0.0043 16.1 4.5 6.5 4 1 1 5 5 5 2 Protein of unknown function (DUF2722) Folate_carrier PF01770.18 CDI83328.1 - 9.3 4.9 5.6 44 2.7 5.6 2.2 1 0 0 1 1 1 0 Reduced folate carrier RAP PF08373.10 CDI83330.1 - 1.6e-12 47.3 0.0 6.8e-12 45.3 0.0 2.1 1 1 0 1 1 1 1 RAP domain FF PF01846.19 CDI83332.1 - 0.0038 17.4 0.2 2.3 8.5 0.0 2.2 2 0 0 2 2 2 2 FF domain THOC7 PF05615.13 CDI83332.1 - 2 8.7 12.0 0.81 10.0 2.4 2.3 1 1 1 2 2 2 0 Tho complex subunit 7 DUF2722 PF10846.8 CDI83333.1 - 5.2e-08 32.3 33.3 0.0012 17.9 6.7 3.1 3 0 0 3 3 3 3 Protein of unknown function (DUF2722) Eapp_C PF10238.9 CDI83333.1 - 5e-05 23.4 5.6 0.32 11.1 0.0 3.4 3 0 0 3 3 3 2 E2F-associated phosphoprotein HNOBA PF07701.14 CDI83333.1 - 0.00024 20.6 3.3 0.18 11.2 0.3 3.2 3 0 0 3 3 3 2 Heme NO binding associated Spt20 PF12090.8 CDI83333.1 - 0.00025 20.7 57.2 0.0003 20.5 8.1 3.4 3 0 0 3 3 3 2 Spt20 family DUF2828 PF11443.8 CDI83333.1 - 0.00047 18.4 0.2 0.071 11.2 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF2828) Rxt3 PF08642.10 CDI83333.1 - 0.0023 18.7 6.1 0.19 12.5 0.2 3.4 3 0 0 3 3 3 1 Histone deacetylation protein Rxt3 CPSF100_C PF13299.6 CDI83333.1 - 0.0024 18.1 4.5 1.6 8.9 0.0 3.3 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal MecA PF05389.12 CDI83333.1 - 0.018 14.7 4.7 1.7 8.2 0.0 3.1 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) DUF4834 PF16118.5 CDI83333.1 - 0.03 15.3 0.3 0.03 15.3 0.3 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) DUF2076 PF09849.9 CDI83333.1 - 0.042 13.9 43.4 0.56 10.2 8.8 3.5 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2076) FAM60A PF15396.6 CDI83333.1 - 0.085 12.9 5.8 8.1 6.4 0.1 3.4 3 0 0 3 3 3 0 Protein Family FAM60A FHIPEP PF00771.20 CDI83333.1 - 0.23 9.9 10.2 2 6.8 0.7 3.1 3 0 0 3 3 3 0 FHIPEP family Suf PF05843.14 CDI83333.1 - 0.3 11.0 31.1 0.48 10.4 1.9 3.2 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) DUF719 PF05334.13 CDI83333.1 - 0.31 11.2 15.9 4.9 7.3 0.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF719) TFIIA PF03153.13 CDI83333.1 - 0.34 10.9 60.5 0.025 14.6 6.1 3.3 3 1 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit PIP5K PF01504.18 CDI83333.1 - 0.43 9.7 9.0 24 4.0 9.0 2.3 1 1 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase LMBR1 PF04791.16 CDI83333.1 - 1.1 8.1 8.4 11 4.8 8.4 2.3 1 1 0 1 1 1 0 LMBR1-like membrane protein BRF1 PF07741.13 CDI83333.1 - 1.3 9.4 14.8 6.7 7.1 0.6 3.3 3 0 0 3 3 3 0 Brf1-like TBP-binding domain DUF2956 PF11169.8 CDI83333.1 - 1.7 8.9 27.5 0.17 12.1 2.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) WSD PF15613.6 CDI83333.1 - 1.8 9.1 7.0 11 6.6 0.6 3.1 3 0 0 3 3 3 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DUF2370 PF10176.9 CDI83333.1 - 2.1 8.0 5.0 5.1 6.7 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2370) Orf78 PF06024.12 CDI83333.1 - 2.9 8.2 13.8 3.7 7.9 0.2 3.6 4 0 0 4 4 3 0 Orf78 (ac78) DUF775 PF05603.12 CDI83333.1 - 6.9 6.1 21.5 3.2 7.2 3.3 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF775) Mit_KHE1 PF10173.9 CDI83333.1 - 7.9 6.5 10.9 4.1 7.4 0.3 3.0 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related DUF2232 PF09991.9 CDI83333.1 - 9.4 5.3 12.9 2.2 7.4 0.0 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2232) APG12 PF04110.13 CDI83334.1 - 7.5e-06 26.3 0.0 1.9e-05 25.0 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like autophagy protein Apg12 Pex14_N PF04695.13 CDI83334.1 - 0.023 15.3 9.7 0.023 15.3 9.7 3.8 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 CDI83334.1 - 0.043 13.8 51.8 0.47 10.4 20.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 CDI83334.1 - 0.063 13.8 14.7 0.063 13.8 1.8 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDI83334.1 - 0.18 12.1 4.4 0.19 12.0 0.0 2.6 2 1 1 3 3 3 0 AAA domain AAA-ATPase_like PF09820.9 CDI83334.1 - 0.31 10.4 3.9 0.47 9.8 0.0 2.1 2 0 0 2 2 2 0 Predicted AAA-ATPase RskA PF10099.9 CDI83334.1 - 0.52 10.6 27.0 0.097 13.0 7.1 2.7 2 1 1 3 3 3 0 Anti-sigma-K factor rskA Helicase_RecD PF05127.14 CDI83334.1 - 0.86 9.4 0.0 0.86 9.4 0.0 2.6 3 0 0 3 3 3 0 Helicase AAA PF00004.29 CDI83334.1 - 2.4 8.6 4.2 1.3 9.5 0.1 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Acetyltransf_1 PF00583.25 CDI83335.1 - 6.7e-05 23.1 0.1 0.012 15.9 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Spt20 PF12090.8 CDI83337.1 - 1.1 8.9 15.2 4.3 6.9 9.4 2.1 2 0 0 2 2 2 0 Spt20 family EF-hand_8 PF13833.6 CDI83338.1 - 0.016 15.0 0.0 0.073 12.9 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair Fusion_gly PF00523.18 CDI83338.1 - 0.3 9.3 5.1 0.091 11.0 0.8 2.0 2 0 0 2 2 2 0 Fusion glycoprotein F0 OATP PF03137.20 CDI83345.1 - 0.02 13.2 0.1 0.02 13.2 0.1 1.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TMEM51 PF15345.6 CDI83345.1 - 0.027 14.3 3.5 0.054 13.3 3.5 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 FAM176 PF14851.6 CDI83345.1 - 0.11 12.1 0.1 0.23 11.1 0.1 1.5 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.13 CDI83345.1 - 0.55 10.2 9.8 0.88 9.5 9.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Agouti PF05039.12 CDI83345.1 - 0.65 10.7 15.6 2.2 9.1 7.2 2.5 2 0 0 2 2 2 0 Agouti protein WRNPLPNID PF15017.6 CDI83345.1 - 1.5 9.8 6.8 3.8 8.4 6.8 1.6 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box DUF4834 PF16118.5 CDI83345.1 - 5.4 8.0 6.7 0.46 11.5 1.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) IMCp PF12314.8 CDI83346.1 - 4.9e-16 58.8 53.7 5.6e-10 39.4 22.5 3.4 2 1 1 3 3 3 2 Inner membrane complex protein Thioredoxin PF00085.20 CDI83347.1 - 2.2e-29 101.5 0.0 3.5e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CDI83347.1 - 3.7e-05 23.6 0.0 5.4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 CDI83347.1 - 0.00019 21.9 0.0 0.00053 20.4 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDI83347.1 - 0.00075 19.3 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 CDI83347.1 - 0.0032 17.4 0.0 0.0064 16.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDI83347.1 - 0.015 15.7 0.0 0.093 13.1 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_7 PF13899.6 CDI83347.1 - 0.017 15.3 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_3 PF13192.6 CDI83347.1 - 0.043 13.9 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Redoxin PF08534.10 CDI83347.1 - 0.075 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Redoxin HyaE PF07449.11 CDI83347.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 CDI83347.1 - 0.14 12.0 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family JAB PF01398.21 CDI83348.1 - 7.2e-12 45.3 0.0 1.2e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDI83348.1 - 9.6e-09 35.7 0.0 1.3e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function HTH_3 PF01381.22 CDI83348.1 - 0.0043 17.1 0.0 0.012 15.6 0.0 1.8 1 1 1 2 2 2 1 Helix-turn-helix Urb2 PF10441.9 CDI83349.1 - 0.33 10.9 4.6 0.8 9.6 1.4 2.6 2 1 0 2 2 2 0 Urb2/Npa2 family Baculo_PEP_C PF04513.12 CDI83349.1 - 1.5 8.9 7.5 0.95 9.5 4.3 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DFF-C PF09033.10 CDI83349.1 - 1.7 8.5 8.2 0.37 10.7 1.6 2.7 3 0 0 3 3 3 0 DNA Fragmentation factor 45kDa, C terminal domain DUF489 PF04356.12 CDI83351.1 - 0.00018 21.6 2.5 0.15 12.0 0.2 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF489) TMF_TATA_bd PF12325.8 CDI83351.1 - 0.003 17.7 20.7 0.023 14.9 18.2 2.5 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding DASH_Duo1 PF08651.10 CDI83351.1 - 0.0049 16.6 1.2 3.9 7.3 0.1 2.7 2 0 0 2 2 2 2 DASH complex subunit Duo1 PKcGMP_CC PF16808.5 CDI83351.1 - 0.016 15.0 2.8 0.016 15.0 2.8 3.4 3 1 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4407 PF14362.6 CDI83351.1 - 0.036 13.4 8.4 0.058 12.7 8.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_13 PF13166.6 CDI83351.1 - 0.05 12.3 9.2 0.084 11.5 9.2 1.4 1 1 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.8 CDI83351.1 - 0.093 12.7 23.2 0.036 14.0 9.7 3.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding YjcZ PF13990.6 CDI83351.1 - 0.11 11.9 4.8 0.044 13.2 2.3 1.6 1 1 0 1 1 1 0 YjcZ-like protein FAM76 PF16046.5 CDI83351.1 - 0.14 11.5 11.4 0.053 12.9 6.0 2.0 1 1 1 2 2 2 0 FAM76 protein DUF1515 PF07439.11 CDI83351.1 - 0.22 11.6 6.4 4.2 7.4 1.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) SPATA24 PF15175.6 CDI83351.1 - 0.24 11.3 11.5 0.35 10.7 11.5 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 Exonuc_VII_L PF02601.15 CDI83351.1 - 0.25 10.9 6.8 0.34 10.5 6.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FliJ PF02050.16 CDI83351.1 - 0.26 11.5 13.2 2.7 8.2 6.2 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein FapA PF03961.13 CDI83351.1 - 0.31 9.6 6.5 0.17 10.5 4.6 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF641 PF04859.12 CDI83351.1 - 0.43 10.9 13.4 0.15 12.4 2.1 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Csm1_N PF18504.1 CDI83351.1 - 0.43 11.0 16.4 2 8.8 5.0 3.4 2 1 1 3 3 3 0 Csm1 N-terminal domain TMCO5 PF14992.6 CDI83351.1 - 0.59 9.7 16.1 0.1 12.2 0.7 2.1 1 1 1 2 2 2 0 TMCO5 family Atg14 PF10186.9 CDI83351.1 - 0.63 9.1 10.7 1.4 7.9 10.7 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Flagellin_N PF00669.20 CDI83351.1 - 0.78 9.8 4.9 0.27 11.3 1.6 1.8 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region ATG16 PF08614.11 CDI83351.1 - 0.89 9.8 22.0 0.65 10.2 10.8 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) YabA PF06156.13 CDI83351.1 - 1.2 9.8 11.6 0.27 11.9 5.0 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Fez1 PF06818.15 CDI83351.1 - 1.5 9.2 17.1 5.1 7.5 17.1 1.7 1 1 0 1 1 1 0 Fez1 FlgN PF05130.12 CDI83351.1 - 1.7 9.1 18.5 2.3 8.7 8.6 2.5 1 1 2 3 3 3 0 FlgN protein GAS PF13851.6 CDI83351.1 - 1.8 7.9 21.2 5.2 6.4 11.8 2.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding AATF-Che1 PF13339.6 CDI83351.1 - 2.4 8.9 13.3 0.92 10.2 5.5 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor ZapB PF06005.12 CDI83351.1 - 2.7 8.5 23.9 2.7 8.5 13.0 2.8 2 1 0 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 CDI83351.1 - 2.8 6.8 19.4 1.2 8.0 11.4 1.8 1 1 0 2 2 2 0 Spc7 kinetochore protein CC2-LZ PF16516.5 CDI83351.1 - 3.1 8.2 15.1 31 5.0 7.8 3.1 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Med30 PF11315.8 CDI83351.1 - 4.1 7.6 10.6 4.5 7.5 0.3 2.4 1 1 1 2 2 2 0 Mediator complex subunit 30 V_ATPase_I PF01496.19 CDI83351.1 - 7.9 4.2 6.8 10 3.9 6.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family COG2 PF06148.11 CDI83351.1 - 8.2 6.5 12.5 3.3 7.8 6.5 2.3 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 CDI83351.1 - 8.7 5.5 7.3 3.5 6.8 4.7 1.5 1 1 0 1 1 1 0 TMPIT-like protein UPF0184 PF03670.13 CDI83351.1 - 8.9 6.8 6.9 4.7 7.7 0.4 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) Sec2p PF06428.11 CDI83351.1 - 8.9 6.4 16.8 2 8.4 2.5 2.7 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Hydrolase PF00702.26 CDI83352.1 - 2.4e-07 31.3 0.0 0.011 16.0 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDI83352.1 - 5.3e-07 29.6 0.2 0.00025 20.9 0.0 3.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDI83352.1 - 6.7e-06 26.1 0.0 4.3e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) HAD PF12710.7 CDI83352.1 - 3.1e-05 24.4 0.2 0.11 12.8 0.0 2.6 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDI83352.1 - 0.06 12.9 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Pkip-1 PF06878.11 CDI83352.1 - 0.081 13.0 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Pkip-1 protein TFIIE-A_C PF11521.8 CDI83352.1 - 7.5 6.9 8.0 0.57 10.5 2.5 2.0 2 1 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha RskA PF10099.9 CDI83353.1 - 4.2 7.6 31.9 2.7 8.3 14.3 2.5 2 0 0 2 2 2 0 Anti-sigma-K factor rskA FSA_C PF10479.9 CDI83354.1 - 1.3 7.0 5.4 1.5 6.9 5.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SOG2 PF10428.9 CDI83355.1 - 0.06 12.6 1.9 0.089 12.0 1.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 CDI83355.1 - 6.2 6.7 24.7 0.38 10.7 9.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 CDI83356.1 - 0.0069 16.9 10.1 0.0069 16.9 10.1 9.4 8 1 0 8 8 8 3 60s Acidic ribosomal protein CRT10 PF08728.10 CDI83356.1 - 0.23 9.6 10.5 0.38 8.9 10.5 1.2 1 0 0 1 1 1 0 CRT10 Aminotran_4 PF01063.19 CDI83357.1 - 1.4e-14 54.5 0.0 1.4e-14 54.5 0.0 2.4 3 0 0 3 3 3 1 Amino-transferase class IV SPX PF03105.19 CDI83357.1 - 0.93 9.3 30.4 0.72 9.7 5.0 2.4 2 0 0 2 2 2 0 SPX domain Sin_N PF04801.13 CDI83357.1 - 1.1 8.4 53.1 0.044 13.0 37.1 2.2 2 0 0 2 2 2 0 Sin-like protein conserved region Exonuc_VII_L PF02601.15 CDI83357.1 - 3.4 7.2 31.4 1.1 8.7 26.1 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit SLC12 PF03522.15 CDI83357.1 - 4.4 6.2 35.5 2.1 7.3 25.2 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Cwf_Cwc_15 PF04889.12 CDI83357.1 - 4.4 7.0 36.2 8.2 6.1 2.6 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ndc1_Nup PF09531.10 CDI83357.1 - 4.6 5.8 36.2 0.38 9.4 1.5 2.4 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF572 PF04502.13 CDI83357.1 - 6.6 6.3 30.0 2.5 7.7 18.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) Pkinase PF00069.25 CDI83359.1 - 1.3e-15 57.5 0.0 2.3e-07 30.5 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83359.1 - 0.00067 19.0 0.0 0.0023 17.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PP2C PF00481.21 CDI83360.1 - 5e-28 98.4 8.3 1.6e-17 64.1 0.2 4.6 4 1 1 5 5 5 3 Protein phosphatase 2C EOS1 PF12326.8 CDI83360.1 - 4.8 7.1 8.8 0.82 9.6 0.0 3.3 3 1 0 3 3 3 0 N-glycosylation protein zf-C3HC4_2 PF13923.6 CDI83361.1 - 1e-07 31.7 4.1 1e-07 31.7 4.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDI83361.1 - 1.6e-05 24.9 7.7 1.6e-05 24.9 7.7 4.6 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CDI83361.1 - 0.00013 21.9 4.1 0.00013 21.9 4.1 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDI83361.1 - 0.0003 20.6 7.8 0.0003 20.6 7.8 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) SUIM_assoc PF16619.5 CDI83361.1 - 0.0084 16.2 2.4 0.0084 16.2 2.4 18.2 10 5 1 11 11 11 2 Unstructured region C-term to UIM in Ataxin3 SUIM_assoc PF16619.5 CDI83362.1 - 0.00072 19.6 8.7 0.00072 19.6 8.7 22.3 9 5 8 17 17 17 1 Unstructured region C-term to UIM in Ataxin3 DUF1754 PF08555.10 CDI83363.1 - 0.00018 22.3 0.4 0.00018 22.3 0.4 2.7 2 1 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) RskA PF10099.9 CDI83363.1 - 0.0008 19.8 26.8 0.024 15.0 11.4 2.4 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF3157 PF11355.8 CDI83363.1 - 2.2 7.9 12.4 0.059 13.0 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3157) SR-25 PF10500.9 CDI83364.1 - 0.00052 19.7 11.7 0.00091 18.9 11.7 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI83364.1 - 0.0075 16.3 5.7 0.0075 16.3 5.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1068 PF06364.12 CDI83364.1 - 0.017 15.0 2.6 0.022 14.6 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) GREB1 PF15782.5 CDI83364.1 - 1.7 5.7 6.9 1.7 5.6 6.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 CDI83364.1 - 7 5.3 6.2 8.1 5.1 6.2 1.1 1 0 0 1 1 1 0 Presenilin AP2 PF00847.20 CDI83365.1 - 1.4e-07 31.6 1.1 1.4e-07 31.6 1.1 3.1 3 0 0 3 3 3 1 AP2 domain TSP_1 PF00090.19 CDI83366.1 - 1 9.7 22.0 0.31 11.3 7.1 5.0 4 0 0 4 4 4 0 Thrombospondin type 1 domain Connexin PF00029.19 CDI83367.1 - 0.0087 15.8 10.1 0.32 10.7 2.8 2.9 2 0 0 2 2 2 2 Connexin dsRBD2 PF17842.1 CDI83367.1 - 0.011 15.9 13.3 0.18 12.0 2.7 4.1 3 0 0 3 3 3 0 Double-stranded RNA binding domain 2 MecA PF05389.12 CDI83367.1 - 0.025 14.2 13.5 0.027 14.1 2.0 3.3 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) DUF3506 PF12014.8 CDI83367.1 - 0.3 11.1 7.8 0.12 12.3 1.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) Zip PF02535.22 CDI83367.1 - 0.31 10.2 9.9 0.34 10.1 4.1 2.9 2 0 0 2 2 2 0 ZIP Zinc transporter MAM33 PF02330.16 CDI83367.1 - 0.46 10.4 14.6 0.11 12.4 1.3 3.2 4 0 0 4 4 4 0 Mitochondrial glycoprotein SpoIIP PF07454.11 CDI83367.1 - 0.48 9.8 18.8 0.021 14.3 3.6 2.9 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) PIP5K PF01504.18 CDI83367.1 - 1.2 8.3 15.2 0.42 9.8 1.8 3.0 3 0 0 3 3 3 0 Phosphatidylinositol-4-phosphate 5-Kinase Tim54 PF11711.8 CDI83367.1 - 1.6 7.5 13.6 2.6 6.7 6.9 2.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CLN3 PF02487.17 CDI83367.1 - 1.6 7.7 11.7 1.1 8.2 1.8 3.0 2 0 0 2 2 2 0 CLN3 protein FAM176 PF14851.6 CDI83367.1 - 2.2 7.9 12.0 0.61 9.7 1.8 3.6 4 0 0 4 4 3 0 FAM176 family PAP_RNA-bind PF04926.15 CDI83367.1 - 2.8 7.5 10.0 6.4 6.4 3.1 2.8 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain XAP5 PF04921.14 CDI83367.1 - 3.5 7.4 12.4 1.7 8.4 3.2 2.8 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF913 PF06025.12 CDI83367.1 - 3.8 6.4 25.6 0.15 11.0 6.6 4.1 3 2 0 4 4 4 0 Domain of Unknown Function (DUF913) SART-1 PF03343.13 CDI83367.1 - 7.7 4.9 34.4 0.089 11.3 8.3 2.4 2 0 0 2 2 2 0 SART-1 family DUF4471 PF14740.6 CDI83367.1 - 8.2 5.6 11.9 7.3 5.7 4.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) ORC_WH_C PF18137.1 CDI83367.1 - 8.8 6.4 28.1 1.1 9.3 6.3 4.9 4 0 0 4 4 4 0 Origin recognition complex winged helix C-terminal eIF-3_zeta PF05091.12 CDI83367.1 - 9 5.1 31.1 0.7 8.8 5.1 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Peroxin-13_N PF04088.13 CDI83367.1 - 9.4 6.5 14.2 1.1 9.6 1.9 4.1 3 0 0 3 3 3 0 Peroxin 13, N-terminal region DUF3464 PF11947.8 CDI83367.1 - 9.8 5.9 21.8 0.92 9.2 5.8 3.7 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 DUF4366 PF14283.6 CDI83367.1 - 10 6.2 9.2 56 3.8 4.2 3.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Rtf2 PF04641.12 CDI83369.1 - 6.4 6.1 10.6 1.2 8.5 6.1 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger FH2 PF02181.23 CDI83370.1 - 8.6e-35 120.5 0.0 3.6e-28 98.8 0.0 3.3 4 0 0 4 4 4 2 Formin Homology 2 Domain Bromodomain PF00439.25 CDI83371.1 - 3.1e-09 36.8 0.0 5.6e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain FAM199X PF15814.5 CDI83371.1 - 0.0051 15.9 3.1 0.0071 15.5 3.1 1.1 1 0 0 1 1 1 1 Protein family FAM199X CbiD PF01888.17 CDI83371.1 - 0.26 10.6 2.5 0.52 9.6 0.8 2.0 2 0 0 2 2 2 0 CbiD NrsF PF06532.11 CDI83371.1 - 0.64 9.7 8.9 0.21 11.3 2.4 2.2 2 0 0 2 2 2 0 Negative regulator of sigma F RT_RNaseH_2 PF17919.1 CDI83375.1 - 1.4e-16 60.4 0.0 2.4e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDI83375.1 - 6.1e-06 26.5 0.0 1e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PNK3P PF08645.11 CDI83377.1 - 3.6e-37 127.6 0.0 4.9e-23 81.6 0.0 2.4 2 0 0 2 2 2 2 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CDI83377.1 - 7.9e-11 42.3 0.2 3e-08 33.9 0.1 2.8 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 CDI83377.1 - 8.9e-05 22.9 0.0 0.00022 21.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 CDI83377.1 - 0.00015 21.3 0.8 0.4 10.1 0.1 2.4 1 1 1 2 2 2 2 Chromatin associated protein KTI12 tRNA_lig_kinase PF08303.11 CDI83377.1 - 0.00017 21.7 1.2 0.00018 21.7 0.0 1.7 2 0 0 2 2 1 1 tRNA ligase kinase domain AAA_22 PF13401.6 CDI83377.1 - 0.00025 21.3 0.0 0.00057 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDI83377.1 - 0.0011 18.9 0.1 0.0022 17.9 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase Zeta_toxin PF06414.12 CDI83377.1 - 0.0032 16.8 0.2 0.042 13.1 0.1 2.2 1 1 0 2 2 2 1 Zeta toxin AAA_28 PF13521.6 CDI83377.1 - 0.0041 17.4 0.0 0.0093 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDI83377.1 - 0.0053 17.3 0.3 0.018 15.6 0.0 2.1 2 1 0 2 2 1 1 AAA domain AAA_29 PF13555.6 CDI83377.1 - 0.0088 15.8 0.0 0.025 14.3 0.0 1.7 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 CDI83377.1 - 0.012 15.6 0.1 0.041 13.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MeaB PF03308.16 CDI83377.1 - 0.02 13.9 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 CDI83377.1 - 0.024 14.4 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDI83377.1 - 0.024 15.1 0.0 0.045 14.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 CDI83377.1 - 0.028 14.5 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 CDI83377.1 - 0.033 13.3 0.2 0.048 12.8 0.2 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Ploopntkinase3 PF18751.1 CDI83377.1 - 0.038 13.9 0.0 0.078 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 NACHT PF05729.12 CDI83377.1 - 0.04 13.8 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 CDI83377.1 - 0.067 13.6 0.1 1.4 9.3 0.1 2.9 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CDI83377.1 - 0.076 13.4 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain HAD PF12710.7 CDI83377.1 - 0.086 13.2 0.0 0.35 11.3 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase AAA_10 PF12846.7 CDI83377.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain NB-ARC PF00931.22 CDI83377.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 CDI83377.1 - 0.14 11.8 0.5 0.4 10.3 0.0 2.1 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CDI83377.1 - 0.15 11.7 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 CDI83377.1 - 0.18 11.1 0.1 3.5 6.9 0.0 2.2 1 1 1 2 2 2 0 6-phosphofructo-2-kinase V-ATPase_G PF03179.15 CDI83379.1 - 5.2e-08 33.4 8.1 1.2e-07 32.2 8.1 1.6 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Med9 PF07544.13 CDI83379.1 - 0.2 11.7 2.5 0.27 11.4 1.0 1.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 STAT_int PF02865.17 CDI83379.1 - 0.31 11.5 3.5 0.26 11.7 1.6 1.8 2 0 0 2 2 2 0 STAT protein, protein interaction domain V-ATPase_G_2 PF16999.5 CDI83379.1 - 1.6 9.2 17.5 4.7 7.7 17.5 1.8 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Spc7 PF08317.11 CDI83379.1 - 3.2 6.5 9.5 4.6 6.0 9.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PRIMA1 PF16101.5 CDI83380.1 - 0.021 14.9 1.2 0.27 11.3 0.6 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Myco_arth_vir_N PF09610.10 CDI83380.1 - 0.15 12.1 0.7 0.15 12.1 0.7 2.7 3 0 0 3 3 3 0 Mycoplasma virulence signal region (Myco_arth_vir_N) DUF983 PF06170.12 CDI83380.1 - 1.2 9.6 15.3 0.43 11.0 1.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF983) DA1-like PF12315.8 CDI83382.1 - 3e-09 36.6 6.2 2.9e-06 26.8 0.4 3.2 3 0 0 3 3 3 2 Protein DA1 HCMV_UL139 PF12507.8 CDI83382.1 - 1.3 9.4 10.9 0.11 12.8 2.1 2.9 3 0 0 3 3 3 0 Human Cytomegalovirus UL139 protein Ribosomal_60s PF00428.19 CDI83383.1 - 7e-05 23.3 7.1 7e-05 23.3 7.1 13.5 12 3 3 15 15 15 3 60s Acidic ribosomal protein SUIM_assoc PF16619.5 CDI83383.1 - 1.5 9.0 0.0 0.09 12.9 5.9 8.6 7 3 2 9 9 9 0 Unstructured region C-term to UIM in Ataxin3 ING PF12998.7 CDI83384.1 - 0.00064 20.3 0.0 0.00064 20.3 0.0 2.2 1 1 0 2 2 1 1 Inhibitor of growth proteins N-terminal histone-binding SR-25 PF10500.9 CDI83384.1 - 0.0073 15.9 13.8 0.19 11.3 4.3 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI83384.1 - 0.01 16.2 5.1 0.012 15.9 5.1 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI83384.1 - 0.01 15.8 27.3 20 5.4 27.3 2.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 eIF-3_zeta PF05091.12 CDI83384.1 - 0.034 13.1 6.0 0.037 13.0 6.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Med15 PF09606.10 CDI83384.1 - 0.041 12.6 24.9 0.05 12.3 24.9 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.14 CDI83384.1 - 0.066 13.2 8.9 0.089 12.8 8.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Dehydrin PF00257.19 CDI83384.1 - 0.13 12.8 7.7 1.9 9.0 2.3 2.1 2 0 0 2 2 2 0 Dehydrin DUF755 PF05501.11 CDI83384.1 - 0.23 11.7 23.9 0.8 10.0 3.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) EOS1 PF12326.8 CDI83384.1 - 0.24 11.3 2.3 0.31 11.0 2.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein LPP20 PF02169.16 CDI83384.1 - 0.48 10.8 12.7 0.29 11.5 7.7 2.1 2 0 0 2 2 2 0 LPP20 lipoprotein Erv26 PF04148.13 CDI83384.1 - 0.74 9.6 1.5 1.2 8.9 1.5 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 TERB2 PF15101.6 CDI83384.1 - 0.79 9.7 14.9 1.3 9.1 11.8 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4834 PF16118.5 CDI83384.1 - 0.93 10.5 10.3 0.72 10.9 7.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI83384.1 - 1 8.0 10.4 1.3 7.7 10.4 1.1 1 0 0 1 1 1 0 Presenilin G0-G1_switch_2 PF15103.6 CDI83384.1 - 1.1 9.7 11.1 0.44 11.0 6.7 2.0 2 0 0 2 2 2 0 G0/G1 switch protein 2 Neur_chan_memb PF02932.16 CDI83384.1 - 1.3 9.0 6.8 1.8 8.6 6.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 CDI83384.1 - 1.7 7.7 13.9 0.42 9.7 11.1 1.4 2 0 0 2 2 2 0 Drosophila roughex protein AXIN1_TNKS_BD PF16646.5 CDI83384.1 - 3.7 8.6 8.1 38 5.3 0.1 2.5 2 0 0 2 2 2 0 Axin-1 tankyrase binding domain DUF4770 PF15994.5 CDI83384.1 - 4.6 7.5 11.2 3.3 7.9 9.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Spt20 PF12090.8 CDI83384.1 - 7.9 6.0 31.6 0.17 11.5 25.0 1.5 2 0 0 2 2 2 0 Spt20 family CAF1C_H4-bd PF12265.8 CDI83387.1 - 1.2e-16 60.7 0.0 2.4e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDI83387.1 - 2e-05 25.2 3.4 1.1 10.2 0.0 6.0 6 1 0 6 6 6 1 WD domain, G-beta repeat RskA PF10099.9 CDI83387.1 - 0.00068 20.0 15.1 0.02 15.2 7.3 2.3 2 0 0 2 2 2 2 Anti-sigma-K factor rskA Spt20 PF12090.8 CDI83387.1 - 2.8 7.5 5.3 4.9 6.7 5.3 1.3 1 0 0 1 1 1 0 Spt20 family Symplekin_C PF12295.8 CDI83388.1 - 1.1e-37 130.0 0.4 1.1e-37 130.0 0.4 3.3 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal HSP70 PF00012.20 CDI83388.1 - 2.2 6.3 15.7 5 5.2 15.7 1.5 1 0 0 1 1 1 0 Hsp70 protein RAP1 PF07218.11 CDI83389.1 - 0.0016 16.8 4.6 0.0016 16.8 4.6 1.8 2 0 0 2 2 2 1 Rhoptry-associated protein 1 (RAP-1) PH_RBD PF12068.8 CDI83389.1 - 0.028 13.9 0.7 0.06 12.8 0.7 1.5 1 0 0 1 1 1 0 Rab-binding domain (RBD) DUF5349 PF17298.2 CDI83389.1 - 3 7.5 14.7 1.8 8.2 7.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5349) PA26 PF04636.13 CDI83391.1 - 0.0062 15.5 1.0 0.0088 15.0 1.0 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) RED_N PF07808.13 CDI83391.1 - 0.054 13.1 4.3 0.085 12.4 4.3 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF2967 PF11179.8 CDI83391.1 - 0.11 10.5 0.6 0.13 10.4 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Peptidase_M19 PF01244.21 CDI83391.1 - 0.25 10.5 1.0 0.38 9.9 1.0 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) MCU PF04678.13 CDI83391.1 - 0.55 10.3 4.4 0.96 9.5 4.4 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter RAP1 PF07218.11 CDI83392.1 - 1.3 7.2 13.0 2 6.6 13.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDC45 PF02724.14 CDI83392.1 - 3.1 6.0 9.8 6.1 5.0 9.8 1.4 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.13 CDI83392.1 - 4 7.3 31.3 0.1 12.6 23.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI83393.1 - 0.0033 17.4 40.6 0.014 15.5 0.3 5.4 5 0 0 5 5 5 4 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI83393.1 - 1.1 8.9 33.1 1.9 8.0 5.7 4.4 4 0 0 4 4 4 0 Spt20 family Pkinase PF00069.25 CDI83394.1 - 1.4e-18 67.2 0.0 1.1e-10 41.3 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83394.1 - 6.2e-09 35.5 0.1 0.0033 16.7 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase TFIIA PF03153.13 CDI83395.1 - 0.003 17.6 10.6 0.003 17.6 10.6 2.9 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Imm5 PF14423.6 CDI83395.1 - 3.1 8.0 9.8 0.34 11.1 4.6 2.2 2 0 0 2 2 2 0 Immunity protein Imm5 Secretin_N_2 PF07655.13 CDI83395.1 - 7.1 7.2 27.6 1 9.9 2.3 4.0 4 0 0 4 4 4 0 Secretin N-terminal domain DCP2 PF05026.13 CDI83396.1 - 5.2e-13 49.1 1.4 5.2e-13 49.1 1.4 2.5 3 0 0 3 3 3 1 Dcp2, box A domain NUDIX PF00293.28 CDI83396.1 - 6.5e-13 48.9 0.0 1.6e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain SR-25 PF10500.9 CDI83396.1 - 0.00061 19.5 23.1 0.00061 19.5 23.1 14.2 7 3 2 12 12 12 4 Nuclear RNA-splicing-associated protein LsmAD PF06741.13 CDI83396.1 - 0.00065 20.2 3.1 0.00065 20.2 3.1 3.8 4 0 0 4 4 4 1 LsmAD domain Diphthamide_syn PF01866.17 CDI83398.1 - 0.00065 19.2 0.0 0.24 10.8 0.0 2.7 2 0 0 2 2 2 2 Putative diphthamide synthesis protein Peptidase_S9 PF00326.21 CDI83399.1 - 2.5e-14 53.3 9.9 1.7e-05 24.4 6.9 4.1 2 1 1 3 3 3 2 Prolyl oligopeptidase family DUF3371 PF11851.8 CDI83399.1 - 0.01 16.9 19.3 0.01 16.9 19.3 9.5 7 2 0 7 7 7 0 Domain of unknown function (DUF3371) Zip PF02535.22 CDI83399.1 - 0.026 13.8 4.2 0.021 14.1 1.5 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter TT_ORF1 PF02956.14 CDI83399.1 - 0.34 9.5 13.4 0.038 12.7 7.3 2.5 2 0 0 2 2 2 0 TT viral orf 1 PrgI PF12666.7 CDI83399.1 - 0.79 10.5 2.5 22 5.9 0.0 4.0 5 0 0 5 5 5 0 PrgI family protein Cellulose_synt PF03552.14 CDI83399.1 - 1.6 7.1 4.9 3.1 6.2 4.9 1.4 1 0 0 1 1 1 0 Cellulose synthase O-antigen_lig PF13425.6 CDI83399.1 - 8 5.1 6.6 20 3.8 6.6 1.6 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Cyclin PF08613.11 CDI83402.1 - 1.2e-29 103.8 0.1 5.3e-29 101.7 0.0 2.2 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CDI83402.1 - 2.6e-06 27.2 0.1 2.6e-06 27.2 0.1 3.0 3 0 0 3 3 3 1 Cyclin, N-terminal domain SNF2_N PF00176.23 CDI83405.1 - 1.9e-15 56.4 0.0 1.3e-12 47.2 0.0 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain zf-C4_Topoisom PF01396.19 CDI83405.1 - 7.5e-09 35.2 3.5 2.4e-08 33.6 3.5 1.8 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger HNH PF01844.23 CDI83405.1 - 0.00025 21.2 0.1 0.00086 19.4 0.1 2.0 1 0 0 1 1 1 1 HNH endonuclease Helicase_C PF00271.31 CDI83405.1 - 0.00061 20.1 0.4 0.0019 18.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI83405.1 - 0.0058 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DDHD PF02862.17 CDI83407.1 - 1.3 9.2 8.7 1.5 8.9 8.7 1.2 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.12 CDI83407.1 - 7.8 6.7 17.2 10 6.3 17.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family TCP PF03634.13 CDI83407.1 - 7.9 7.0 20.7 11 6.6 20.7 1.1 1 0 0 1 1 1 0 TCP family transcription factor Glyco_tran_28_C PF04101.16 CDI83408.1 - 2.9e-16 59.9 0.0 5.7e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain LIME1 PF15332.6 CDI83408.1 - 0.55 9.8 4.7 1.2 8.7 4.7 1.5 1 0 0 1 1 1 0 Lck-interacting transmembrane adapter 1 DUF2722 PF10846.8 CDI83410.1 - 4e-06 26.1 2.2 5.8e-06 25.5 2.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Med15 PF09606.10 CDI83410.1 - 8e-05 21.5 1.0 9.3e-05 21.3 1.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Pex14_N PF04695.13 CDI83410.1 - 0.026 15.2 7.6 0.28 11.8 4.8 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Roughex PF06020.11 CDI83410.1 - 0.074 12.1 7.6 0.15 11.1 7.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DUF3464 PF11947.8 CDI83410.1 - 0.14 11.9 0.2 0.14 11.9 0.2 2.2 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 DUF812 PF05667.11 CDI83411.1 - 0.013 14.5 26.4 0.23 10.3 7.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF812) ATP_transf PF09830.9 CDI83411.1 - 0.099 12.8 0.1 20 5.4 0.0 2.8 2 0 0 2 2 2 0 ATP adenylyltransferase Fez1 PF06818.15 CDI83411.1 - 1.2 9.5 26.9 0.01 16.3 10.7 3.0 2 1 0 2 2 2 0 Fez1 Dodecin PF07311.12 CDI83411.1 - 6.9 7.0 12.2 72 3.7 0.0 5.7 6 0 0 6 6 6 0 Dodecin Tho2 PF11262.8 CDI83411.1 - 8 5.6 11.8 21 4.2 11.8 1.6 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Helicase_C PF00271.31 CDI83412.1 - 1.5e-06 28.5 1.2 2.5e-06 27.8 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDI83412.1 - 0.004 16.9 0.5 0.016 15.0 0.5 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_16 PF13191.6 CDI83412.1 - 0.027 14.8 0.6 0.26 11.6 0.1 2.9 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CDI83412.1 - 0.093 13.2 0.2 0.99 9.9 0.0 2.5 2 0 0 2 2 2 0 ABC transporter T2SSE PF00437.20 CDI83412.1 - 0.099 11.7 0.1 0.19 10.8 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 CDI83412.1 - 0.16 12.3 0.1 0.39 11.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDI83412.1 - 1.6 8.4 5.2 0.7 9.6 0.1 2.6 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 CDI83412.1 - 3.4 8.1 10.1 0.77 10.2 0.2 2.5 2 0 0 2 2 2 0 AAA domain ABC1 PF03109.16 CDI83413.1 - 0.0035 17.5 0.4 1 9.6 0.1 2.6 1 1 1 2 2 2 2 ABC1 family RNA_GG_bind PF10258.9 CDI83414.1 - 3.2e-25 88.0 0.1 7e-25 86.9 0.1 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain DUF998 PF06197.13 CDI83415.1 - 2.3 7.8 19.0 61 3.1 17.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF998) SNF2_N PF00176.23 CDI83416.1 - 1.1e-37 129.6 0.2 2.1e-35 122.1 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CDI83416.1 - 1.1e-12 48.3 0.0 2.2e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI83416.1 - 9.8e-05 22.4 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CDI83416.1 - 0.0017 17.7 0.0 0.0032 16.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SWI2_SNF2 PF18766.1 CDI83416.1 - 0.068 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase MA3 PF02847.17 CDI83417.1 - 0.00042 20.3 0.2 0.004 17.1 0.0 2.4 2 0 0 2 2 2 1 MA3 domain SAM_KSR1 PF13543.6 CDI83417.1 - 0.014 15.5 0.1 0.035 14.3 0.1 1.6 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 TFIIA PF03153.13 CDI83417.1 - 1.5 8.7 10.9 2.6 8.0 10.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Vps51 PF08700.11 CDI83418.1 - 0.0032 17.5 0.2 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 Vps51/Vps67 Glycos_transf_1 PF00534.20 CDI83420.1 - 2.8e-15 56.3 0.0 3.6e-14 52.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDI83420.1 - 1e-07 32.1 0.0 4.6e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CDI83420.1 - 0.00012 22.6 0.0 0.00083 19.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 tRNA-synt_2b PF00587.25 CDI83421.1 - 2.2e-27 96.2 0.0 3.4e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Kinesin PF00225.23 CDI83422.1 - 6.8e-79 265.2 1.0 1.6e-76 257.4 1.0 2.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDI83422.1 - 2.5e-19 69.7 0.2 3.3e-16 59.6 0.0 2.8 1 1 1 2 2 2 2 Microtubule binding P5CR_dimer PF14748.6 CDI83423.1 - 9e-29 99.8 0.1 1.8e-28 98.8 0.1 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CDI83423.1 - 0.0019 18.7 2.0 0.8 10.3 1.2 2.4 1 1 1 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent MutL_C PF08676.11 CDI83425.1 - 1.9e-13 50.4 9.8 8.5e-12 45.1 0.0 5.0 5 1 1 6 6 6 2 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CDI83425.1 - 1.6e-12 47.1 0.0 2.8e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CDI83425.1 - 4.8e-08 32.9 0.0 1.5e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDI83425.1 - 6.3e-08 33.1 0.0 2e-07 31.5 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4710 PF15828.5 CDI83426.1 - 0.081 13.0 0.2 0.14 12.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) TFIIA PF03153.13 CDI83426.1 - 0.78 9.7 13.4 0.53 10.2 11.3 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI83426.1 - 3.5 7.2 19.3 0.034 13.8 11.3 1.6 2 0 0 2 2 2 0 Spt20 family PAN_4 PF14295.6 CDI83427.1 - 0.00031 20.6 0.8 0.00059 19.7 0.8 1.5 1 0 0 1 1 1 1 PAN domain RskA PF10099.9 CDI83427.1 - 0.00092 19.6 0.3 0.00092 19.6 0.3 8.5 1 1 4 6 6 6 1 Anti-sigma-K factor rskA ANAPC4_WD40 PF12894.7 CDI83428.1 - 7.1e-13 48.7 0.0 5.6e-06 26.6 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI83428.1 - 1.6e-12 47.7 7.6 0.24 12.3 0.0 7.3 8 0 0 8 8 8 3 WD domain, G-beta repeat Spt20 PF12090.8 CDI83428.1 - 0.0013 18.4 12.2 0.0021 17.7 12.2 1.3 1 0 0 1 1 1 1 Spt20 family Ge1_WD40 PF16529.5 CDI83428.1 - 0.0023 17.0 0.0 7.2 5.5 0.0 3.8 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 CDI83428.1 - 0.19 11.8 0.0 17 5.5 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 CDI83428.1 - 0.25 11.2 0.0 0.46 10.3 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 CDI83428.1 - 0.34 10.1 7.1 14 4.8 3.5 3.8 4 0 0 4 4 4 0 Rab3 GTPase-activating protein regulatory subunit N-terminus P16-Arc PF04699.14 CDI83428.1 - 0.62 10.6 3.3 1.4 9.4 3.3 1.5 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Mitofilin PF09731.9 CDI83428.1 - 8.9 5.0 24.7 0.058 12.2 13.3 2.0 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Brr6_like_C_C PF10104.9 CDI83429.1 - 1.3e-22 80.0 0.0 1.3e-22 80.0 0.0 2.6 3 0 0 3 3 3 1 Di-sulfide bridge nucleocytoplasmic transport domain Exonuc_VII_L PF02601.15 CDI83429.1 - 0.0007 19.2 30.1 0.074 12.6 2.2 3.2 3 0 0 3 3 3 3 Exonuclease VII, large subunit Activator_LAG-3 PF11498.8 CDI83429.1 - 0.0019 17.3 12.3 0.0019 17.3 12.3 4.1 3 1 0 3 3 3 1 Transcriptional activator LAG-3 FAM199X PF15814.5 CDI83429.1 - 0.25 10.4 9.7 0.66 9.0 9.7 1.7 1 0 0 1 1 1 0 Protein family FAM199X DUF2973 PF11189.8 CDI83429.1 - 0.63 10.2 0.0 0.63 10.2 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2973) Presenilin PF01080.17 CDI83429.1 - 3.9 6.1 21.5 0.087 11.6 8.6 3.0 3 0 0 3 3 3 0 Presenilin Sua5_yciO_yrdC PF01300.18 CDI83430.1 - 4e-31 107.9 0.3 1.9e-14 53.6 0.0 3.9 2 1 0 2 2 2 2 Telomere recombination SUA5 PF03481.13 CDI83430.1 - 2.6e-05 24.8 10.5 2.6e-05 24.8 10.5 3.0 1 1 1 2 2 2 1 Putative GTP-binding controlling metal-binding cobW PF02492.19 CDI83430.1 - 0.21 11.2 2.3 0.28 10.7 1.0 1.9 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CDI83430.1 - 7.8 6.9 15.2 3 8.3 7.2 2.3 2 0 0 2 2 2 0 AAA domain SUIM_assoc PF16619.5 CDI83431.1 - 0.00017 21.6 4.0 0.00017 21.6 4.0 8.3 8 1 1 9 9 9 3 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI83431.1 - 0.002 17.8 22.1 0.002 17.8 22.1 6.9 5 2 2 7 7 7 1 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 CDI83431.1 - 0.0036 17.6 21.5 0.0036 17.6 21.5 8.9 7 2 2 9 9 9 2 Domain of unknown function (DUF755) Apt1 PF10351.9 CDI83431.1 - 0.0042 16.0 2.5 0.0042 16.0 2.5 5.5 3 1 0 3 3 3 1 Golgi-body localisation protein domain F-box-like PF12937.7 CDI83431.1 - 0.0059 16.5 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like EPL1 PF10513.9 CDI83431.1 - 0.032 14.6 0.5 0.032 14.6 0.5 5.9 4 1 0 4 4 4 0 Enhancer of polycomb-like zf-RING_2 PF13639.6 CDI83432.1 - 5e-13 49.2 5.1 5e-13 49.2 5.1 2.6 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 CDI83432.1 - 1.3e-09 37.7 4.0 1.3e-09 37.7 4.0 2.5 3 0 0 3 3 2 1 RING-like zinc finger zf-rbx1 PF12678.7 CDI83432.1 - 1.1e-08 35.2 4.8 1.1e-08 35.2 4.8 2.2 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDI83432.1 - 2.8e-08 33.5 2.8 2.8e-08 33.5 2.8 2.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI83432.1 - 3.6e-08 33.3 0.1 3.6e-08 33.3 0.1 2.1 1 1 1 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI83432.1 - 2.6e-07 30.5 3.1 2.6e-07 30.5 3.1 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDI83432.1 - 2.7e-07 30.3 4.2 2.7e-07 30.3 4.2 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI83432.1 - 4.9e-05 23.1 5.4 4.9e-05 23.1 5.4 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDI83432.1 - 0.00022 21.0 5.5 0.00022 21.0 5.5 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 CDI83432.1 - 0.0034 17.3 0.8 0.0034 17.3 0.8 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 CDI83432.1 - 0.036 13.7 14.9 0.12 12.1 14.9 1.9 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C2HC_2 PF13913.6 CDI83432.1 - 0.14 12.1 0.0 0.14 12.1 0.0 3.2 3 0 0 3 3 2 0 zinc-finger of a C2HC-type zf-ANAPC11 PF12861.7 CDI83432.1 - 0.19 11.8 10.7 0.053 13.6 6.2 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 CDI83432.1 - 0.42 10.8 11.8 18 5.6 11.1 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain Rtf2 PF04641.12 CDI83432.1 - 0.87 8.9 4.4 0.97 8.7 4.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Baculo_IE-1 PF05290.11 CDI83432.1 - 4.8 7.1 10.0 8.4 6.3 10.0 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) STOP PF05217.12 CDI83434.1 - 0.00011 22.4 8.5 0.0011 19.2 1.0 5.2 6 0 0 6 6 6 1 STOP protein PDEase_I PF00233.19 CDI83435.1 - 7.8e-55 186.2 2.2 7.5e-53 179.7 0.5 2.5 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Ctr PF04145.15 CDI83435.1 - 1.5 9.5 4.0 15 6.2 0.1 3.5 3 1 0 3 3 3 0 Ctr copper transporter family SET PF00856.28 CDI83436.1 - 2.2e-07 31.4 0.0 7.4e-07 29.7 0.0 1.9 1 1 0 1 1 1 1 SET domain RNB PF00773.19 CDI83438.1 - 2.1e-60 204.8 18.7 4.4e-39 134.7 0.0 4.7 5 0 0 5 5 5 3 RNB domain DUF2722 PF10846.8 CDI83441.1 - 0.0006 18.9 13.3 0.0006 18.9 13.3 8.4 6 2 1 7 7 7 3 Protein of unknown function (DUF2722) SR-25 PF10500.9 CDI83441.1 - 0.0025 17.5 8.0 0.0025 17.5 8.0 10.3 9 2 2 11 11 11 3 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI83441.1 - 0.11 12.6 0.0 0.11 12.6 0.0 13.9 9 5 3 12 12 12 0 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI83444.1 - 6.7e-05 22.0 1.0 0.00011 21.3 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI83444.1 - 0.00072 19.7 9.5 0.0012 19.0 9.5 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 CDI83444.1 - 0.0091 16.3 11.9 0.0091 16.3 11.9 2.0 1 1 0 1 1 1 1 Anti-sigma-K factor rskA DUF4834 PF16118.5 CDI83444.1 - 0.41 11.6 4.4 0.3 12.1 1.3 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Protamine_P2 PF00841.19 CDI83444.1 - 0.64 10.5 7.3 1.8 9.1 7.3 1.7 1 0 0 1 1 1 0 Sperm histone P2 RCR PF12273.8 CDI83444.1 - 2.8 8.6 8.7 0.24 12.1 0.7 2.3 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red Suf PF05843.14 CDI83444.1 - 3.5 7.5 7.2 7.1 6.5 7.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Tim54 PF11711.8 CDI83444.1 - 4.1 6.1 6.5 5.6 5.7 0.5 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Activator_LAG-3 PF11498.8 CDI83444.1 - 4.4 6.2 22.1 8.4 5.2 22.1 1.4 1 1 0 1 1 1 0 Transcriptional activator LAG-3 SWI-SNF_Ssr4 PF08549.10 CDI83444.1 - 6.9 5.2 12.0 0.37 9.4 1.8 2.3 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) SARAF PF06682.12 CDI83444.1 - 9.2 5.8 11.3 0.042 13.5 2.2 1.6 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis RCC1 PF00415.18 CDI83445.1 - 4.1e-09 36.9 5.7 0.011 16.3 0.0 4.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat TFIIA PF03153.13 CDI83445.1 - 1.6e-05 25.1 28.8 1.6e-05 25.1 28.8 5.4 4 1 0 5 5 5 3 Transcription factor IIA, alpha/beta subunit RCC1_2 PF13540.6 CDI83445.1 - 3.9e-05 23.3 0.1 3.9e-05 23.3 0.1 4.8 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat SpoIIIAH PF12685.7 CDI83445.1 - 0.0011 18.9 0.2 0.0011 18.9 0.2 4.9 5 0 0 5 5 5 1 SpoIIIAH-like protein DDHD PF02862.17 CDI83445.1 - 0.0028 17.9 41.8 0.013 15.7 4.5 5.6 5 0 0 5 5 5 3 DDHD domain Exonuc_VII_L PF02601.15 CDI83445.1 - 0.0032 17.1 10.8 0.0032 17.1 10.8 5.0 5 0 0 5 5 5 1 Exonuclease VII, large subunit SAGA-Tad1 PF12767.7 CDI83445.1 - 0.0036 17.1 6.5 0.0036 17.1 6.5 5.2 5 0 0 5 5 5 4 Transcriptional regulator of RNA polII, SAGA, subunit RNA_pol_Rpc4 PF05132.14 CDI83445.1 - 0.004 17.6 9.6 0.004 17.6 9.6 6.3 5 1 0 5 5 5 2 RNA polymerase III RPC4 Peptidase_C2 PF00648.21 CDI83446.1 - 4.5e-05 22.6 0.0 0.00012 21.3 0.0 1.6 1 0 0 1 1 1 1 Calpain family cysteine protease MID_MedPIWI PF18296.1 CDI83446.1 - 0.0076 16.1 17.1 0.024 14.4 1.3 3.8 3 0 0 3 3 3 1 MID domain of medPIWI HNOBA PF07701.14 CDI83446.1 - 0.056 12.9 5.6 1 8.7 0.0 3.2 3 0 0 3 3 3 0 Heme NO binding associated MecA PF05389.12 CDI83446.1 - 0.097 12.3 14.5 0.56 9.8 0.4 3.4 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) PIP5K PF01504.18 CDI83446.1 - 0.85 8.8 12.0 3.5 6.8 0.5 3.1 3 0 0 3 3 3 0 Phosphatidylinositol-4-phosphate 5-Kinase EOS1 PF12326.8 CDI83446.1 - 1.6 8.7 5.5 6.3 6.7 0.3 3.1 3 0 0 3 3 3 0 N-glycosylation protein PRC2_HTH_1 PF18118.1 CDI83446.1 - 1.9 9.3 17.1 5.6 7.8 2.8 3.7 3 0 0 3 3 3 0 Polycomb repressive complex 2 tri-helical domain Folliculin PF11704.8 CDI83446.1 - 4.6 7.1 25.4 0.23 11.3 3.6 3.8 4 0 0 4 4 4 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 CDI83446.1 - 5.1 5.7 28.5 0.27 9.9 3.5 3.3 3 0 0 3 3 3 0 Presenilin FAM176 PF14851.6 CDI83446.1 - 6.6 6.4 12.1 15 5.3 1.5 3.4 3 0 0 3 3 3 0 FAM176 family Pkinase PF00069.25 CDI83447.1 - 2.3e-09 37.0 0.0 5.2e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83447.1 - 8.4e-07 28.5 0.0 1.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase SR-25 PF10500.9 CDI83447.1 - 0.35 10.5 22.5 0.03 13.9 17.2 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SR-25 PF10500.9 CDI83452.1 - 0.0004 20.1 5.6 0.0004 20.1 5.6 8.1 4 3 4 8 8 8 2 Nuclear RNA-splicing-associated protein Vps53_N PF04100.12 CDI83454.1 - 1.3e-35 123.1 49.5 4.4e-29 101.6 3.9 4.3 3 2 1 4 4 4 2 Vps53-like, N-terminal SLC12 PF03522.15 CDI83454.1 - 4.5 6.2 33.0 1.9 7.4 12.3 2.5 2 0 0 2 2 2 0 Solute carrier family 12 ALMT PF11744.8 CDI83454.1 - 4.8 5.9 35.8 2.4 6.9 17.5 2.5 2 0 0 2 2 2 0 Aluminium activated malate transporter SPX PF03105.19 CDI83454.1 - 5.3 6.9 47.0 1.1 9.1 14.0 3.6 3 1 0 3 3 3 0 SPX domain SID-1_RNA_chan PF13965.6 CDI83454.1 - 5.7 5.2 10.2 8.7 4.6 0.1 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Glyoxalase PF00903.25 CDI83458.1 - 0.0042 17.3 0.0 0.02 15.1 0.0 2.2 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily IF3_C PF00707.22 CDI83459.1 - 5.8e-18 64.6 0.0 1.9e-17 63.0 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain CbiD PF01888.17 CDI83459.1 - 0.42 9.9 4.6 2.7 7.2 0.3 2.4 2 0 0 2 2 2 0 CbiD DCP1 PF06058.13 CDI83460.1 - 1.8e-13 50.4 3.8 4.9e-06 26.5 0.0 2.9 3 0 0 3 3 3 2 Dcp1-like decapping family EPL1 PF10513.9 CDI83460.1 - 0.82 10.0 29.7 0.15 12.5 9.7 3.3 3 0 0 3 3 3 0 Enhancer of polycomb-like Bud13 PF09736.9 CDI83460.1 - 3.9 7.9 32.2 0.17 12.3 10.8 3.4 3 0 0 3 3 3 0 Pre-mRNA-splicing factor of RES complex GSH_synth_ATP PF03917.17 CDI83461.1 - 3.4e-59 200.5 9.7 1.2e-57 195.5 9.7 2.9 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CDI83461.1 - 1.4e-16 60.7 1.1 1.3e-15 57.7 1.1 2.4 1 1 0 1 1 1 1 Eukaryotic glutathione synthase DUF755 PF05501.11 CDI83461.1 - 0.0034 17.6 0.9 0.0034 17.6 0.9 7.2 6 1 1 7 7 7 1 Domain of unknown function (DUF755) Ribosomal_60s PF00428.19 CDI83461.1 - 0.64 10.6 70.8 0.71 10.5 5.7 5.7 5 0 0 5 5 5 0 60s Acidic ribosomal protein Orf78 PF06024.12 CDI83461.1 - 1.6 9.1 12.0 4.3 7.7 0.1 4.5 5 0 0 5 5 5 0 Orf78 (ac78) EPL1 PF10513.9 CDI83461.1 - 2.8 8.3 19.0 2 8.8 1.4 4.7 5 0 0 5 5 5 0 Enhancer of polycomb-like zf-C3HC4 PF00097.25 CDI83464.1 - 0.08 12.8 0.5 0.18 11.7 0.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI83464.1 - 0.23 11.3 2.4 0.55 10.1 1.1 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) LSM PF01423.22 CDI83465.1 - 6e-16 57.9 0.2 8.9e-16 57.3 0.2 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDI83465.1 - 0.015 15.0 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Hfq protein SPC22 PF04573.12 CDI83466.1 - 2.3e-41 141.1 0.0 3.2e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 Signal peptidase subunit His_Phos_1 PF00300.22 CDI83467.1 - 0.026 14.2 0.2 0.62 9.7 0.2 2.6 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) PRIMA1 PF16101.5 CDI83467.1 - 0.1 12.6 5.4 5.1 7.2 1.1 2.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 His_Phos_1 PF00300.22 CDI83468.1 - 0.00012 21.9 0.4 0.28 10.8 0.2 2.4 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.22 CDI83469.1 - 7.1e-08 32.4 5.4 0.048 13.4 0.0 3.9 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) Jnk-SapK_ap_N PF09744.9 CDI83475.1 - 0.0067 16.7 35.9 0.0067 16.7 35.9 4.4 2 2 1 3 3 3 1 JNK_SAPK-associated protein-1 PTPRCAP PF15713.5 CDI83475.1 - 0.013 15.8 1.8 0.013 15.8 1.8 3.9 1 1 1 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Seryl_tRNA_N PF02403.22 CDI83475.1 - 0.014 15.6 13.5 0.014 15.6 13.5 5.3 1 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain BING4CT PF08149.11 CDI83477.1 - 0.012 15.4 0.5 0.14 12.0 0.0 3.2 2 0 0 2 2 2 0 BING4CT (NUC141) domain CNDH2_C PF16858.5 CDI83477.1 - 0.33 10.8 0.0 0.33 10.8 0.0 14.7 13 4 2 16 16 16 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SR-25 PF10500.9 CDI83480.1 - 6.4e-08 32.5 22.4 7.4e-08 32.3 22.4 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDI83480.1 - 0.62 10.6 10.5 0.65 10.5 10.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein NARP1 PF12569.8 CDI83480.1 - 1.1 8.0 8.7 1.2 7.9 8.7 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Spem1 PF15670.5 CDI83480.1 - 2.4 7.6 10.8 3 7.3 10.8 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 IMUP PF15761.5 CDI83480.1 - 2.7 8.7 22.5 5.9 7.6 22.5 1.6 1 1 0 1 1 1 0 Immortalisation up-regulated protein Dsh_C PF12316.8 CDI83480.1 - 3.3 8.1 12.9 3.8 7.9 12.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Presenilin PF01080.17 CDI83480.1 - 8.7 5.0 14.7 9.3 4.9 14.7 1.1 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 CDI83480.1 - 9.6 3.2 12.0 11 3.0 12.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer KfrA_N PF11740.8 CDI83481.1 - 0.99 10.1 21.8 1.2 9.9 21.8 1.1 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DUF4410 PF14366.6 CDI83481.1 - 4.6 7.2 7.1 5.3 7.0 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) Plasmodium_Vir PF05795.11 CDI83481.1 - 7.6 5.8 8.7 7.9 5.8 8.7 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4175 PF13779.6 CDI83481.1 - 7.8 4.3 24.3 8.1 4.2 24.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Hydin_ADK PF17213.3 CDI83481.1 - 8 6.7 11.6 8.9 6.5 11.6 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain YL1 PF05764.13 CDI83482.1 - 1.5e-08 35.1 53.9 1.5e-08 35.1 53.9 4.3 3 2 0 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 CDI83482.1 - 3.5e-07 29.9 0.0 5.7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain RcsD_ABL PF16359.5 CDI83482.1 - 0.028 14.6 0.1 0.076 13.1 0.1 1.7 1 0 0 1 1 1 0 RcsD-ABL domain Rrn6 PF10214.9 CDI83482.1 - 0.71 8.3 37.8 1.4 7.3 37.8 1.5 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF384 PF04064.13 CDI83482.1 - 1 9.2 4.2 0.4 10.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF384) DUF5372 PF17342.2 CDI83482.1 - 4 7.9 5.1 36 4.9 2.2 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5372) Kelch_5 PF13854.6 CDI83483.1 - 3.2e-14 52.5 7.2 0.012 15.6 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 CDI83483.1 - 4.3e-14 52.2 9.2 6.1e-05 22.9 0.0 6.1 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 CDI83483.1 - 4e-10 39.1 10.2 0.057 13.0 0.0 6.0 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 CDI83483.1 - 0.00015 22.0 17.5 0.17 12.2 0.1 7.1 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI83483.1 - 0.00019 21.6 12.9 6.1 7.3 0.0 5.9 5 1 1 6 6 6 3 Kelch motif Caldesmon PF02029.15 CDI83483.1 - 0.00028 19.8 48.8 0.00028 19.8 48.8 3.9 5 0 0 5 5 5 1 Caldesmon Kelch_2 PF07646.15 CDI83483.1 - 0.0014 18.5 12.3 0.2 11.7 0.0 5.8 6 0 0 6 6 6 2 Kelch motif Pkinase PF00069.25 CDI83484.1 - 4.3e-55 186.9 0.0 4.3e-55 186.9 0.0 2.6 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83484.1 - 1.3e-33 116.4 0.6 2.4e-32 112.2 0.0 2.7 2 0 0 2 2 2 1 Protein tyrosine kinase Mlf1IP PF10248.9 CDI83485.1 - 0.021 14.8 2.8 0.31 11.0 0.1 2.2 2 0 0 2 2 2 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein MID_MedPIWI PF18296.1 CDI83485.1 - 1.7 8.3 7.5 8.7 6.1 2.9 2.3 2 0 0 2 2 2 0 MID domain of medPIWI MFS_1 PF07690.16 CDI83486.1 - 8.8e-32 110.4 27.8 1.9e-27 96.1 10.2 3.2 2 2 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDI83486.1 - 3.1e-08 32.9 13.0 7.5e-07 28.4 8.9 2.4 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 CDI83486.1 - 0.0011 17.9 0.1 0.0074 15.2 0.1 2.5 1 1 0 1 1 1 1 MFS_1 like family SET PF00856.28 CDI83488.1 - 1.6e-13 51.4 0.2 4.6e-11 43.4 0.0 3.1 2 1 0 2 2 2 1 SET domain DUF5308 PF17233.2 CDI83488.1 - 0.69 10.1 7.1 9.3 6.4 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) SpoIIE PF07228.12 CDI83489.1 - 1.6e-07 31.4 0.1 1.5e-05 25.0 0.1 3.2 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) SUIM_assoc PF16619.5 CDI83489.1 - 0.0031 17.5 1.3 0.0031 17.5 1.3 4.6 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 Spore_YhcN_YlaJ PF09580.10 CDI83489.1 - 1.1 9.3 10.4 2.1 8.4 1.1 2.9 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AP2 PF00847.20 CDI83490.1 - 1.3e-16 60.5 3.3 2.8e-12 46.6 0.1 2.6 2 0 0 2 2 2 2 AP2 domain ACDC PF14733.6 CDI83490.1 - 0.0019 18.5 0.0 0.0044 17.3 0.0 1.6 1 0 0 1 1 1 1 AP2-coincident C-terminal FeoC PF09012.10 CDI83493.1 - 0.084 13.0 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 FeoC like transcriptional regulator Methyltransf_16 PF10294.9 CDI83494.1 - 2.3e-06 27.4 0.0 0.0048 16.7 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase RRM_1 PF00076.22 CDI83496.1 - 3.1e-08 33.3 0.0 5.6e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDI83496.1 - 0.047 13.6 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif AHSA1 PF08327.11 CDI83497.1 - 0.043 14.0 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein Dehydrin PF00257.19 CDI83498.1 - 0.0053 17.3 0.3 0.0053 17.3 0.3 2.6 3 0 0 3 3 3 1 Dehydrin Spore_III_AF PF09581.10 CDI83498.1 - 5.6 7.0 8.7 15 5.6 1.8 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) Pro_isomerase PF00160.21 CDI83500.1 - 9.6e-35 120.2 0.0 1.9e-34 119.2 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4479 PF14794.6 CDI83500.1 - 0.033 14.0 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) Apt1 PF10351.9 CDI83501.1 - 1.6 7.5 7.3 2.2 7.0 7.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI83501.1 - 8.2 4.9 7.7 15 4.0 7.7 1.4 1 0 0 1 1 1 0 Macoilin family DUF2722 PF10846.8 CDI83502.1 - 2.7e-06 26.6 10.7 2.7e-06 26.6 10.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) ubiquitin PF00240.23 CDI83502.1 - 3.1e-05 23.6 0.0 3.1e-05 23.6 0.0 2.2 3 0 0 3 3 1 1 Ubiquitin family DUF4175 PF13779.6 CDI83502.1 - 0.00019 19.6 13.2 0.00019 19.6 13.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Pex14_N PF04695.13 CDI83502.1 - 0.0013 19.4 7.0 0.002 18.8 7.0 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 CDI83502.1 - 0.0017 17.2 0.5 0.0017 17.2 0.5 1.1 1 0 0 1 1 1 1 Presenilin Med15 PF09606.10 CDI83502.1 - 0.0021 16.9 18.0 0.0027 16.5 18.0 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Velvet PF11754.8 CDI83502.1 - 0.0021 18.1 2.7 0.0027 17.7 2.7 1.2 1 0 0 1 1 1 1 Velvet factor ANAPC_CDC26 PF10471.9 CDI83502.1 - 0.0046 17.8 18.3 0.0046 17.8 18.3 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex APC subunit CDC26 Suf PF05843.14 CDI83502.1 - 0.0049 16.9 6.7 0.0059 16.6 6.7 1.2 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DDHD PF02862.17 CDI83502.1 - 0.0058 16.8 0.8 0.0058 16.8 0.8 1.2 1 0 0 1 1 1 1 DDHD domain eIF-3_zeta PF05091.12 CDI83502.1 - 0.0087 15.1 7.5 0.0098 14.9 7.5 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MCU PF04678.13 CDI83502.1 - 0.0097 16.0 2.0 0.018 15.1 2.0 1.5 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Spt20 PF12090.8 CDI83502.1 - 0.011 15.4 28.5 0.011 15.4 28.5 1.4 2 0 0 2 2 1 0 Spt20 family SpoIIP PF07454.11 CDI83502.1 - 0.012 15.1 2.8 0.014 14.9 2.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Band_3_cyto PF07565.13 CDI83502.1 - 0.016 15.1 0.8 0.014 15.2 0.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Rad60-SLD PF11976.8 CDI83502.1 - 0.019 14.8 0.0 0.019 14.8 0.0 2.3 2 1 0 2 2 1 0 Ubiquitin-2 like Rad60 SUMO-like Connexin PF00029.19 CDI83502.1 - 0.021 14.6 0.8 0.029 14.2 0.8 1.2 1 0 0 1 1 1 0 Connexin FHIPEP PF00771.20 CDI83502.1 - 0.033 12.7 1.0 0.031 12.8 1.0 1.2 1 0 0 1 1 1 0 FHIPEP family Peroxin-13_N PF04088.13 CDI83502.1 - 0.033 14.5 1.6 0.049 13.9 1.6 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Het-C PF07217.11 CDI83502.1 - 0.033 12.7 2.9 0.044 12.3 2.9 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C 7tm_1 PF00001.21 CDI83502.1 - 0.043 13.1 2.6 0.066 12.5 2.6 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Orf78 PF06024.12 CDI83502.1 - 0.046 14.0 2.3 0.087 13.1 2.3 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DcuA_DcuB PF03605.14 CDI83502.1 - 0.051 12.5 0.5 0.068 12.1 0.5 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter ArsP_2 PF11449.8 CDI83502.1 - 0.054 12.7 0.2 0.067 12.4 0.2 1.2 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter DUF2207 PF09972.9 CDI83502.1 - 0.079 11.7 0.0 0.094 11.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4834 PF16118.5 CDI83502.1 - 0.085 13.8 9.9 0.15 13.0 9.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EIIBC-GUT_N PF03612.14 CDI83502.1 - 0.096 12.4 4.0 0.14 11.9 4.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2407 PF10302.9 CDI83502.1 - 0.11 13.0 8.0 0.83 10.2 0.0 2.3 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain GWT1 PF06423.12 CDI83502.1 - 0.19 11.9 0.2 0.3 11.2 0.2 1.4 1 0 0 1 1 1 0 GWT1 Neur_chan_memb PF02932.16 CDI83502.1 - 0.2 11.7 1.4 0.24 11.4 1.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 CDI83502.1 - 0.21 11.6 13.0 0.35 10.9 12.2 1.7 2 0 0 2 2 2 0 Telomere-associated protein TERB2 EOS1 PF12326.8 CDI83502.1 - 0.21 11.5 1.4 0.29 11.0 1.4 1.3 1 0 0 1 1 1 0 N-glycosylation protein PigN PF04987.14 CDI83502.1 - 0.25 10.2 2.4 0.34 9.7 2.4 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) CLN3 PF02487.17 CDI83502.1 - 0.25 10.4 1.1 0.29 10.1 1.1 1.1 1 0 0 1 1 1 0 CLN3 protein Glt_symporter PF03616.14 CDI83502.1 - 0.25 10.0 0.8 0.39 9.4 0.8 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter ABC2_membrane_2 PF12679.7 CDI83502.1 - 0.54 9.5 4.9 0.93 8.7 5.0 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF3464 PF11947.8 CDI83502.1 - 0.72 9.6 7.7 1.1 9.0 7.7 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF5336 PF17270.2 CDI83502.1 - 0.74 9.4 6.3 1.2 8.8 6.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5336) SprA-related PF12118.8 CDI83502.1 - 1.1 8.4 19.4 1.7 7.7 19.4 1.3 1 0 0 1 1 1 0 SprA-related family DUF4199 PF13858.6 CDI83502.1 - 1.4 9.3 4.6 2.1 8.7 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) MscS_TM PF12794.7 CDI83502.1 - 1.4 7.7 5.7 2.4 6.9 5.7 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Renin_r PF07850.14 CDI83502.1 - 3 8.5 4.4 6.7 7.4 4.4 1.6 1 1 0 1 1 1 0 Renin receptor-like protein Baculo_PP31 PF05311.11 CDI83502.1 - 3.5 7.0 9.2 4.8 6.6 9.2 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Sec7 PF01369.20 CDI83506.1 - 1.2e-26 93.5 0.7 2.9e-26 92.3 0.1 1.9 2 0 0 2 2 2 1 Sec7 domain FAM199X PF15814.5 CDI83506.1 - 0.0003 20.0 6.7 0.0003 20.0 6.7 9.4 10 1 1 11 11 11 1 Protein family FAM199X Spt20 PF12090.8 CDI83506.1 - 0.0012 18.5 11.0 0.0012 18.5 11.0 8.8 9 0 0 9 9 9 5 Spt20 family Period_C PF12114.8 CDI83506.1 - 0.0025 17.4 20.6 0.0025 17.4 20.6 7.0 8 0 0 8 8 8 1 Period protein 2/3C-terminal region SDA1 PF05285.12 CDI83506.1 - 0.0034 16.9 4.0 0.0034 16.9 4.0 5.5 7 0 0 7 7 7 2 SDA1 Otopetrin PF03189.13 CDI83506.1 - 0.026 13.3 0.1 0.026 13.3 0.1 3.5 4 1 0 4 4 4 0 Otopetrin SNF2_N PF00176.23 CDI83507.1 - 2.2e-51 174.6 0.0 5.4e-51 173.4 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain PHD PF00628.29 CDI83507.1 - 2.6e-19 68.8 85.4 2.3e-10 40.2 6.2 7.2 7 1 0 7 7 7 4 PHD-finger Helicase_C PF00271.31 CDI83507.1 - 3.9e-15 56.1 0.0 1.2e-14 54.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI83507.1 - 3.5e-08 33.6 0.0 9.4e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PHD_2 PF13831.6 CDI83507.1 - 0.0013 18.3 1.5 0.0013 18.3 1.5 6.8 7 0 0 7 7 6 1 PHD-finger C1_1 PF00130.22 CDI83507.1 - 0.0018 18.1 1.4 0.0018 18.1 1.4 7.6 6 1 1 7 7 6 4 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 CDI83507.1 - 0.0046 16.6 1.0 0.0046 16.6 1.0 7.2 6 2 2 8 8 8 3 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 CDI83507.1 - 0.0049 16.8 2.6 0.0049 16.8 2.6 6.8 7 0 0 7 7 5 2 Prokaryotic RING finger family 1 AAA_14 PF13173.6 CDI83507.1 - 0.0051 16.9 0.0 0.017 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF4710 PF15828.5 CDI83507.1 - 0.18 12.0 5.4 0.052 13.7 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) PHD_4 PF16866.5 CDI83507.1 - 0.91 9.7 67.0 0.011 15.8 5.7 6.7 6 1 0 6 6 5 0 PHD-finger TPH PF13868.6 CDI83508.1 - 4.2 5.8 121.9 5.3 5.4 5.7 3.1 2 1 0 2 2 2 0 Trichohyalin-plectin-homology domain SET PF00856.28 CDI83509.1 - 4.6e-15 56.4 4.6 1.7e-12 48.0 0.0 3.8 4 0 0 4 4 4 2 SET domain Gp-FAR-1 PF05823.12 CDI83509.1 - 0.046 14.1 11.5 0.049 14.0 6.5 3.0 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) RapA_C PF12137.8 CDI83509.1 - 0.62 9.0 8.3 1.1 8.2 8.3 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal DNA_pol_delta_4 PF04081.13 CDI83509.1 - 1.2 9.5 6.8 4.4 7.7 6.8 2.0 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 Phlebovirus_NSM PF07246.11 CDI83509.1 - 1.7 8.0 5.2 3.6 6.9 5.2 1.5 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M ADIP PF11559.8 CDI83509.1 - 1.7 8.7 13.0 4.7 7.3 13.0 1.7 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMPIT PF07851.13 CDI83509.1 - 2.1 7.5 5.8 3.8 6.7 5.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein HypA PF01155.19 CDI83509.1 - 7 6.7 6.3 0.61 10.1 1.1 1.9 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Arm PF00514.23 CDI83511.1 - 7e-08 32.3 6.3 0.24 11.5 0.0 6.1 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 CDI83511.1 - 1e-06 28.8 0.0 1.2e-05 25.4 0.0 2.5 3 0 0 3 3 3 1 V-ATPase subunit H HEAT_2 PF13646.6 CDI83511.1 - 3.5e-05 24.1 0.1 0.021 15.2 0.0 3.8 2 1 2 4 4 4 1 HEAT repeats HEAT PF02985.22 CDI83511.1 - 0.046 14.0 4.6 31 5.2 0.0 4.8 4 0 0 4 4 4 0 HEAT repeat Proteasom_PSMB PF10508.9 CDI83511.1 - 0.91 8.0 3.4 2.8 6.3 3.3 1.7 1 1 0 1 1 1 0 Proteasome non-ATPase 26S subunit Tim17 PF02466.19 CDI83513.1 - 7.2e-23 81.1 6.8 1.1e-22 80.5 6.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Adeno_PIX PF03955.14 CDI83516.1 - 0.0054 16.9 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Adenovirus hexon-associated protein (IX) DHO_dh PF01180.21 CDI83517.1 - 2.6e-102 342.0 0.0 3.1e-102 341.8 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 CDI83517.1 - 0.0018 17.4 0.1 0.084 11.9 0.3 2.4 2 1 0 2 2 2 2 FMN-dependent dehydrogenase CarD_CdnL_TRCF PF02559.16 CDI83517.1 - 0.16 12.7 0.0 0.32 11.7 0.0 1.4 1 0 0 1 1 1 0 CarD-like/TRCF domain UvrD-helicase PF00580.21 CDI83518.1 - 2.9e-35 122.3 0.1 1.9e-32 113.1 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CDI83518.1 - 5.9e-30 104.8 0.0 7.6e-25 88.0 0.0 4.1 3 2 0 3 3 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CDI83518.1 - 5.5e-16 59.2 0.0 1.3e-15 58.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDI83518.1 - 2.4e-10 40.1 1.1 0.00022 21.0 0.0 2.7 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_12 PF13087.6 CDI83518.1 - 0.023 14.3 0.0 0.023 14.3 0.0 2.3 2 0 0 2 2 1 0 AAA domain EPL1 PF10513.9 CDI83518.1 - 0.14 12.6 13.5 0.33 11.3 13.5 1.7 1 0 0 1 1 1 0 Enhancer of polycomb-like AAA_11 PF13086.6 CDI83518.1 - 1 9.1 16.4 3.3 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain TFIIA PF03153.13 CDI83518.1 - 2.6 7.9 28.7 6.2 6.7 28.7 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 CDI83518.1 - 4 5.6 11.8 7 4.8 11.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.15 CDI83518.1 - 4.7 6.7 16.2 8.1 5.9 16.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 CDI83518.1 - 7.8 5.1 17.5 14 4.3 17.5 1.3 1 0 0 1 1 1 0 Presenilin RNase_H2_suC PF08615.11 CDI83519.1 - 0.0097 16.1 0.8 0.061 13.5 0.8 2.3 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PH_2 PF08458.10 CDI83519.1 - 0.079 13.3 0.1 1.7 9.0 0.0 2.8 1 1 1 2 2 2 0 Plant pleckstrin homology-like region PRKCSH PF07915.13 CDI83520.1 - 3.5e-12 47.2 0.0 9.7e-06 26.5 0.0 3.0 2 1 0 2 2 2 2 Glucosidase II beta subunit-like protein YccV-like PF08755.11 CDI83520.1 - 6.9e-11 42.5 0.1 1.7e-10 41.2 0.1 1.7 1 1 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like TPR_12 PF13424.6 CDI83521.1 - 1.4e-06 28.4 13.0 0.015 15.6 0.8 3.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CDI83521.1 - 0.00018 21.0 8.6 0.00018 21.0 8.6 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_1 PF00515.28 CDI83521.1 - 0.0003 20.5 5.0 0.86 9.5 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDI83521.1 - 0.0037 17.2 9.2 0.06 13.4 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI83521.1 - 0.17 12.1 10.6 3.4 8.1 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI83521.1 - 0.28 11.7 0.2 0.28 11.7 0.2 3.7 5 1 0 5 5 5 0 Tetratricopeptide repeat Importin_rep_4 PF18808.1 CDI83521.1 - 0.34 11.2 4.3 5.3 7.4 0.0 2.3 1 1 0 2 2 2 0 Importin repeat TPR_2 PF07719.17 CDI83521.1 - 0.34 11.1 15.6 4.6 7.6 0.6 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDI83521.1 - 0.35 10.8 4.1 4.9 7.2 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC5 PF12862.7 CDI83521.1 - 8.7 6.5 9.2 2.3 8.3 0.1 2.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 PCI PF01399.27 CDI83522.1 - 0.00011 22.6 0.3 0.00011 22.6 0.3 3.0 3 0 0 3 3 3 1 PCI domain RskA PF10099.9 CDI83522.1 - 0.00046 20.5 5.3 0.00046 20.5 5.3 4.4 1 1 1 2 2 2 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI83522.1 - 0.0014 18.6 5.5 0.0014 18.6 5.5 7.3 3 2 1 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 Peptidase_M50 PF02163.22 CDI83523.1 - 0.47 9.7 2.9 18 4.5 0.1 2.8 2 1 0 2 2 2 0 Peptidase family M50 Eapp_C PF10238.9 CDI83524.1 - 0.028 14.5 1.0 0.028 14.5 1.0 3.9 5 0 0 5 5 5 0 E2F-associated phosphoprotein Herpes_UL74 PF07982.12 CDI83524.1 - 5.6 5.8 7.2 9.5 5.1 7.2 1.2 1 0 0 1 1 1 0 Herpes UL74 glycoproteins Mucin PF01456.17 CDI83524.1 - 7 6.6 24.6 2.6 8.0 17.5 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein Cullin PF00888.22 CDI83529.1 - 4.2e-12 45.5 0.0 7.4e-12 44.7 0.0 1.4 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CDI83529.1 - 1.7e-09 37.6 0.1 3e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 Cullin protein neddylation domain SpoIIE PF07228.12 CDI83529.1 - 0.015 15.2 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) MORN PF02493.20 CDI83535.1 - 1.2e-50 166.4 55.5 1.7e-06 27.5 2.8 10.2 10 0 0 10 10 10 10 MORN repeat DUF3048_C PF17479.2 CDI83535.1 - 6.7 7.1 10.2 9.4 6.7 0.5 3.9 2 1 1 4 4 4 0 Protein of unknown function (DUF3048) C-terminal domain Ras PF00071.22 CDI83536.1 - 6e-59 198.3 0.0 7.6e-59 197.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI83536.1 - 1.4e-33 115.6 0.0 2.1e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI83536.1 - 1.9e-12 47.0 0.0 2.4e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDI83536.1 - 3.9e-06 26.4 0.0 4.7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDI83536.1 - 0.00031 20.8 0.0 0.00045 20.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDI83536.1 - 0.01 15.8 0.0 3.3 7.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 CDI83536.1 - 0.027 14.0 0.0 0.13 11.8 0.0 1.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDI83536.1 - 0.093 13.1 0.0 0.12 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 CDI83536.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Pkinase_Tyr PF07714.17 CDI83537.1 - 4.1e-34 118.0 0.0 3.6e-16 59.2 0.0 5.1 2 2 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDI83537.1 - 1.1e-33 116.7 0.0 1.5e-24 86.8 0.0 3.8 3 1 0 3 3 3 2 Protein kinase domain DUF5533 PF17685.1 CDI83537.1 - 0.21 12.0 0.1 0.4 11.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5533) AAA PF00004.29 CDI83538.1 - 8.8e-17 61.8 0.0 1.4e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDI83538.1 - 3.2e-12 46.5 0.0 1.3e-08 34.8 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase III, delta subunit AAA_30 PF13604.6 CDI83538.1 - 2.4e-06 27.4 0.1 1.5e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDI83538.1 - 2.5e-06 28.0 0.1 0.0001 22.7 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDI83538.1 - 2.6e-06 27.7 0.1 3.4e-05 24.1 0.1 2.3 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CDI83538.1 - 7.2e-06 26.1 0.0 1.6e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_11 PF13086.6 CDI83538.1 - 1.6e-05 24.8 0.1 6.4e-05 22.9 0.0 1.8 1 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CDI83538.1 - 3.7e-05 23.8 0.0 6.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 CDI83538.1 - 0.0012 18.9 0.0 0.0081 16.2 0.0 1.9 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit RuvB_N PF05496.12 CDI83538.1 - 0.0026 17.5 0.0 0.0094 15.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDI83538.1 - 0.0033 17.4 0.0 0.013 15.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 CDI83538.1 - 0.0053 17.1 0.1 0.023 15.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CDI83538.1 - 0.01 15.1 0.0 0.024 13.9 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 CDI83538.1 - 0.013 15.0 0.0 0.034 13.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 CDI83538.1 - 0.017 14.5 0.0 0.74 9.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein DEAD PF00270.29 CDI83538.1 - 0.018 14.8 0.1 0.32 10.7 0.0 2.3 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_24 PF13479.6 CDI83538.1 - 0.023 14.4 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDI83538.1 - 0.031 13.5 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 CDI83538.1 - 0.049 13.0 0.1 0.31 10.4 0.1 2.1 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Rep_fac_C PF08542.11 CDI83538.1 - 0.11 13.0 0.1 5.8 7.4 0.0 2.6 1 1 1 2 2 2 0 Replication factor C C-terminal domain AAA_33 PF13671.6 CDI83538.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 CDI83538.1 - 0.17 11.3 0.0 5.1 6.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Spt4 PF06093.13 CDI83538.1 - 0.26 11.4 1.5 0.53 10.4 1.5 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger DUF2894 PF11445.8 CDI83540.1 - 0.0022 18.5 2.3 0.0034 17.9 2.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2894) SHE3 PF17078.5 CDI83540.1 - 0.004 16.9 4.7 0.0057 16.4 4.7 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Cob_adeno_trans PF01923.18 CDI83540.1 - 0.012 15.7 3.5 0.015 15.5 3.0 1.4 1 1 0 1 1 1 0 Cobalamin adenosyltransferase CLZ PF16526.5 CDI83540.1 - 0.015 15.6 2.0 0.015 15.6 2.0 2.8 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AAA_15 PF13175.6 CDI83540.1 - 0.017 14.9 2.0 0.02 14.6 2.0 1.0 1 0 0 1 1 1 0 AAA ATPase domain TetR PF13972.6 CDI83540.1 - 0.031 14.0 1.2 0.77 9.5 0.3 2.2 2 0 0 2 2 2 0 Bacterial transcriptional repressor Cnn_1N PF07989.11 CDI83540.1 - 0.057 13.6 10.0 0.073 13.2 2.6 2.8 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 ApoLp-III PF07464.11 CDI83540.1 - 0.084 13.0 7.3 0.61 10.2 7.0 2.0 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 CDI83540.1 - 0.14 12.2 3.2 0.25 11.4 3.1 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1481 PF07356.12 CDI83540.1 - 0.16 11.7 2.4 0.31 10.8 1.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1481) Prominin PF05478.11 CDI83540.1 - 0.17 9.8 1.5 0.18 9.7 1.5 1.1 1 0 0 1 1 1 0 Prominin YecM PF06185.12 CDI83540.1 - 0.2 11.3 3.4 0.38 10.4 2.2 1.8 1 1 1 2 2 2 0 YecM protein Bcr-Abl_Oligo PF09036.10 CDI83540.1 - 0.2 11.7 2.0 0.35 10.9 0.7 1.9 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain FapA PF03961.13 CDI83540.1 - 0.21 10.1 6.2 0.26 9.8 6.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A YkuI_C PF10388.9 CDI83540.1 - 0.22 11.3 1.8 0.32 10.8 1.8 1.2 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain Exonuc_VII_L PF02601.15 CDI83540.1 - 0.35 10.4 7.4 0.44 10.1 7.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 CDI83540.1 - 0.36 10.9 4.2 0.69 10.0 3.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Tho2 PF11262.8 CDI83540.1 - 0.59 9.3 6.2 0.47 9.6 5.3 1.3 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 V_ATPase_I PF01496.19 CDI83540.1 - 0.98 7.3 5.0 1.3 6.9 5.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 CDI83540.1 - 1.1 8.5 9.1 1.5 8.1 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 CDI83540.1 - 1.5 7.6 14.9 2.8 6.7 14.9 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein CCDC-167 PF15188.6 CDI83540.1 - 1.6 9.2 10.8 1.9 8.9 4.7 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Macoilin PF09726.9 CDI83540.1 - 1.9 6.9 12.3 2.4 6.6 12.3 1.0 1 0 0 1 1 1 0 Macoilin family MIF4G_like_2 PF09090.11 CDI83540.1 - 2.2 7.7 9.2 3 7.3 9.2 1.3 1 1 0 1 1 1 0 MIF4G like DUF3584 PF12128.8 CDI83540.1 - 2.5 5.5 14.6 4.5 4.6 14.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) FUSC PF04632.12 CDI83540.1 - 4.3 5.7 7.1 5.4 5.4 7.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.9 CDI83540.1 - 5.1 6.1 12.7 7.9 5.5 12.7 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LMBR1 PF04791.16 CDI83540.1 - 7.7 5.3 4.8 9.6 5.0 4.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 CDI83540.1 - 8.2 5.6 9.0 5.7 6.1 7.1 1.6 1 1 0 1 1 1 0 TMPIT-like protein Cation_efflux PF01545.21 CDI83541.1 - 1.1e-43 149.3 7.4 1.5e-43 148.9 7.4 1.1 1 0 0 1 1 1 1 Cation efflux family DUF4407 PF14362.6 CDI83541.1 - 1.3 8.3 12.3 0.015 14.7 2.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DNA_pol_A_exo1 PF01612.20 CDI83544.1 - 4e-25 88.5 0.0 8.6e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 3'-5' exonuclease ARGLU PF15346.6 CDI83544.1 - 1.3 8.9 21.1 0.078 12.9 3.7 3.3 3 0 0 3 3 3 0 Arginine and glutamate-rich 1 FAM176 PF14851.6 CDI83544.1 - 6.5 6.4 6.3 2.7 7.6 0.1 2.9 3 0 0 3 3 3 0 FAM176 family RNase_T PF00929.24 CDI83545.1 - 3.9e-31 108.8 0.0 4.4e-31 108.6 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CDI83545.1 - 0.0022 18.0 0.0 0.0027 17.7 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like eIF2A PF08662.11 CDI83546.1 - 7.5e-39 133.6 0.0 5.8e-38 130.7 0.0 2.4 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A GYF PF02213.16 CDI83546.1 - 4.4e-16 58.3 0.0 9.6e-16 57.2 0.0 1.6 1 0 0 1 1 1 1 GYF domain TRAM_LAG1_CLN8 PF03798.16 CDI83547.1 - 6.1e-05 22.9 7.3 0.018 14.8 2.6 2.2 1 1 1 2 2 2 2 TLC domain DUF4079 PF13301.6 CDI83548.1 - 0.091 12.9 0.1 0.28 11.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) Arf PF00025.21 CDI83549.1 - 2.4e-54 183.4 0.0 2.8e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDI83549.1 - 1.4e-10 40.9 0.0 1.8e-10 40.5 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CDI83549.1 - 3.8e-10 39.4 0.1 1.9e-07 30.6 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CDI83549.1 - 8.5e-10 38.9 0.0 2e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDI83549.1 - 1.3e-09 37.9 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CDI83549.1 - 8.5e-08 32.3 0.0 1.1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDI83549.1 - 6.8e-06 25.6 0.0 8.8e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDI83549.1 - 0.00017 21.2 0.1 0.0049 16.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 CDI83549.1 - 0.0091 15.6 0.0 0.57 9.7 0.0 2.0 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CDI83549.1 - 0.012 15.5 0.0 4.4 7.2 0.0 2.1 1 1 1 2 2 2 0 RsgA GTPase CENP-M PF11111.8 CDI83549.1 - 0.019 14.1 0.0 0.043 13.0 0.0 1.5 2 0 0 2 2 2 0 Centromere protein M (CENP-M) AAA_28 PF13521.6 CDI83549.1 - 0.06 13.6 0.0 0.63 10.3 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 CDI83549.1 - 0.067 13.5 0.0 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 CDI83549.1 - 0.089 12.3 0.0 0.74 9.3 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 CDI83549.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FAST_1 PF06743.15 CDI83551.1 - 0.007 16.3 1.6 0.74 9.8 0.0 4.7 3 2 2 5 5 5 1 FAST kinase-like protein, subdomain 1 SUIM_assoc PF16619.5 CDI83551.1 - 0.28 11.3 15.3 0.027 14.5 2.6 3.5 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDI83552.1 - 0.00099 19.2 31.9 0.00099 19.2 31.9 8.9 9 1 0 9 9 9 6 Transcription factor IIA, alpha/beta subunit BAF1_ABF1 PF04684.13 CDI83552.1 - 0.0014 17.8 1.2 0.0014 17.8 1.2 7.0 6 1 0 6 6 6 1 BAF1 / ABF1 chromatin reorganising factor Phostensin_N PF13916.6 CDI83552.1 - 0.0086 16.4 0.2 0.0086 16.4 0.2 10.1 9 3 0 9 9 9 1 PP1-regulatory protein, Phostensin N-terminal CK_II_beta PF01214.18 CDI83553.1 - 6.4e-40 136.9 0.0 1.2e-39 136.0 0.0 1.4 2 0 0 2 2 2 1 Casein kinase II regulatory subunit RNA_pol_3_Rpc31 PF11705.8 CDI83553.1 - 0.047 13.9 2.6 0.068 13.4 2.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Radial_spoke PF04712.12 CDI83553.1 - 0.048 12.6 5.0 0.059 12.3 5.0 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein DNA_pol_phi PF04931.13 CDI83553.1 - 3 5.8 7.4 3.3 5.7 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi AAA_33 PF13671.6 CDI83555.1 - 9.8e-28 97.1 0.1 2.7e-27 95.7 0.1 1.8 1 0 0 1 1 1 1 AAA domain SPRY PF00622.28 CDI83555.1 - 1.6e-20 73.4 1.9 1.7e-20 73.4 0.2 2.0 2 0 0 2 2 2 1 SPRY domain AAA_18 PF13238.6 CDI83555.1 - 0.062 13.9 0.2 0.24 11.9 0.2 2.0 1 1 0 1 1 1 0 AAA domain GREB1 PF15782.5 CDI83555.1 - 0.14 9.3 8.8 0.21 8.6 8.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_M28 PF04389.17 CDI83557.1 - 1e-24 87.3 2.1 4.1e-24 85.4 0.0 2.9 2 1 0 2 2 2 1 Peptidase family M28 UPF0560 PF10577.9 CDI83557.1 - 0.00075 18.2 7.2 0.00075 18.2 7.2 2.3 2 0 0 2 2 2 1 Uncharacterised protein family UPF0560 RLL PF10036.9 CDI83557.1 - 0.0067 16.3 6.0 0.0067 16.3 6.0 3.2 3 0 0 3 3 3 1 RNA transcription, translation and transport factor protein Ctr PF04145.15 CDI83557.1 - 0.0076 16.9 2.6 7.1 7.2 2.0 3.5 3 0 0 3 3 3 0 Ctr copper transporter family AAA_23 PF13476.6 CDI83557.1 - 0.0085 16.6 1.3 0.0085 16.6 1.3 2.1 2 0 0 2 2 2 1 AAA domain DUF4834 PF16118.5 CDI83557.1 - 0.021 15.8 15.4 0.62 11.1 8.1 3.2 3 0 0 3 3 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 CDI83557.1 - 0.055 12.2 9.9 0.038 12.8 4.9 2.6 2 0 0 2 2 2 0 Presenilin Connexin PF00029.19 CDI83557.1 - 0.067 12.9 8.5 0.023 14.5 1.9 3.0 3 0 0 3 3 3 0 Connexin TERB2 PF15101.6 CDI83557.1 - 0.15 12.1 21.6 0.018 15.1 11.4 2.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CLN3 PF02487.17 CDI83557.1 - 0.17 10.9 11.1 0.65 9.0 2.7 3.1 3 0 0 3 3 3 0 CLN3 protein Folate_carrier PF01770.18 CDI83557.1 - 0.25 10.0 6.7 0.093 11.5 2.3 2.2 2 0 0 2 2 2 0 Reduced folate carrier FHIPEP PF00771.20 CDI83557.1 - 0.29 9.5 4.9 0.38 9.2 1.4 2.2 2 0 0 2 2 2 0 FHIPEP family Rxt3 PF08642.10 CDI83557.1 - 0.32 11.8 4.0 2.3 9.0 0.5 2.7 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 eIF-3_zeta PF05091.12 CDI83557.1 - 0.35 9.8 12.6 0.011 14.8 3.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EIIBC-GUT_N PF03612.14 CDI83557.1 - 0.38 10.5 10.3 0.22 11.2 5.4 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Spt20 PF12090.8 CDI83557.1 - 0.41 10.2 44.8 2.4 7.7 5.5 2.5 2 0 0 2 2 2 0 Spt20 family MecA PF05389.12 CDI83557.1 - 0.46 10.1 8.6 0.2 11.3 1.8 2.6 3 0 0 3 3 2 0 Negative regulator of genetic competence (MecA) FAM176 PF14851.6 CDI83557.1 - 0.89 9.2 14.3 0.93 9.1 3.7 3.7 4 0 0 4 4 4 0 FAM176 family CSRNP_N PF16019.5 CDI83557.1 - 0.91 9.4 13.5 1.7 8.5 7.3 2.4 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus EPL1 PF10513.9 CDI83557.1 - 0.94 9.9 14.0 8.1 6.8 9.9 2.6 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF4770 PF15994.5 CDI83557.1 - 1.5 9.1 11.4 1.4 9.1 6.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Velvet PF11754.8 CDI83557.1 - 1.5 8.7 10.9 0.73 9.7 4.9 2.7 2 0 0 2 2 2 0 Velvet factor DUF4484 PF14831.6 CDI83557.1 - 1.7 8.7 12.0 11 6.0 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4484) DUF3402 PF11882.8 CDI83557.1 - 1.7 7.7 12.1 17 4.3 7.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3402) DUF702 PF05142.12 CDI83557.1 - 2.1 8.8 14.0 0.48 10.9 6.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Gti1_Pac2 PF09729.9 CDI83557.1 - 2.2 8.4 9.0 3 7.9 5.5 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family DUF2722 PF10846.8 CDI83557.1 - 3.1 6.6 34.2 0.13 11.2 17.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) PIP5K PF01504.18 CDI83557.1 - 3.4 6.8 12.5 4.4 6.4 9.6 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Suf PF05843.14 CDI83557.1 - 3.4 7.6 15.6 2.2 8.2 9.9 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.12 CDI83557.1 - 4.2 7.1 16.4 1.7 8.4 10.8 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI83557.1 - 6 6.8 7.4 5.2 7.0 4.3 2.2 2 0 0 2 2 2 0 Protein Family FAM60A SpoIIP PF07454.11 CDI83557.1 - 6.3 6.2 17.7 2.5 7.5 10.7 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 CDI83557.1 - 7 5.3 11.9 1.6 7.4 5.9 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF2681 PF10883.8 CDI83557.1 - 8 6.9 28.4 19 5.7 16.1 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Metallophos PF00149.28 CDI83558.1 - 6.5e-32 111.7 0.0 9.7e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 CDI83558.1 - 6.3e-16 58.4 0.0 1.8e-15 57.0 0.0 1.8 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_2 PF07719.17 CDI83558.1 - 2.3e-14 52.3 2.4 0.00082 19.3 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDI83558.1 - 2.9e-11 42.7 2.2 0.011 15.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDI83558.1 - 1.4e-05 25.3 0.3 0.0061 16.8 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI83558.1 - 0.00018 21.5 0.4 0.12 12.7 0.0 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI83558.1 - 0.0002 21.0 0.5 0.11 12.2 0.1 2.9 2 1 0 2 2 2 2 TPR repeat TPR_9 PF13371.6 CDI83558.1 - 0.00038 20.5 0.0 0.00082 19.5 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI83558.1 - 0.0014 19.3 0.1 3.9 8.5 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI83558.1 - 0.046 14.1 0.1 0.21 12.0 0.1 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDI83558.1 - 0.051 14.1 1.5 40 4.8 0.9 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDI83558.1 - 0.084 13.5 0.5 14 6.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat U5_2-snRNA_bdg PF10597.9 CDI83559.1 - 0.00027 21.0 0.0 1.1 9.3 0.0 3.0 1 1 2 3 3 3 2 U5-snRNA binding site 2 of PrP8 Spc7_C2 PF15577.6 CDI83559.1 - 0.059 13.5 2.3 58 3.9 0.1 3.1 3 0 0 3 3 3 0 Spc7_C2 PDCD7 PF16021.5 CDI83559.1 - 0.38 9.8 3.3 28 3.7 0.1 2.9 1 1 2 3 3 3 0 Programmed cell death protein 7 GTP_EFTU PF00009.27 CDI83560.1 - 2.5e-29 102.2 0.0 1.1e-28 100.1 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CDI83560.1 - 7.9e-18 64.5 0.3 2e-17 63.2 0.3 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 CDI83560.1 - 1.3e-14 53.8 0.6 1.3e-14 53.8 0.6 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 CDI83560.1 - 2.5e-06 27.5 0.0 1.4e-05 25.1 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CDI83560.1 - 0.00074 19.9 3.1 0.0038 17.6 1.1 3.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 Roc PF08477.13 CDI83560.1 - 0.0074 16.5 0.0 0.021 15.0 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CDI83560.1 - 0.012 15.4 0.0 0.039 13.7 0.0 1.9 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CDI83560.1 - 0.36 11.1 0.0 0.36 11.1 0.0 2.9 4 0 0 4 4 4 0 AAA domain DUF3807 PF12720.7 CDI83561.1 - 0.014 15.7 3.2 0.014 15.7 3.2 4.1 4 0 0 4 4 3 0 Protein of unknown function (DUF3807) RskA PF10099.9 CDI83561.1 - 0.017 15.4 3.0 0.017 15.4 3.0 4.9 2 1 1 3 3 1 0 Anti-sigma-K factor rskA RNA_pol_Rpc4 PF05132.14 CDI83561.1 - 0.022 15.2 0.3 0.022 15.2 0.3 4.6 5 0 0 5 5 4 0 RNA polymerase III RPC4 DUF4834 PF16118.5 CDI83561.1 - 0.036 15.0 3.7 0.036 15.0 3.7 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) MecA PF05389.12 CDI83561.1 - 0.069 12.8 12.7 0.87 9.2 1.3 3.4 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) Otopetrin PF03189.13 CDI83561.1 - 0.13 11.1 4.8 2.5 6.8 0.7 2.3 2 0 0 2 2 2 0 Otopetrin DUF2722 PF10846.8 CDI83561.1 - 0.26 10.2 55.2 0.025 13.5 11.4 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) Connexin PF00029.19 CDI83561.1 - 0.3 10.8 14.2 0.31 10.8 1.0 3.2 3 0 0 3 3 3 0 Connexin SpoIIP PF07454.11 CDI83561.1 - 0.31 10.5 19.5 0.097 12.1 1.2 3.3 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) DUF2464 PF10240.9 CDI83561.1 - 0.38 10.3 10.6 6.2 6.3 1.0 3.3 3 0 0 3 3 3 0 Multivesicular body subunit 12 CPSF100_C PF13299.6 CDI83561.1 - 0.62 10.2 19.6 0.6 10.3 0.2 4.1 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal AAR2 PF05282.11 CDI83561.1 - 1.3 8.3 13.4 0.071 12.5 1.7 2.7 3 0 0 3 3 3 0 AAR2 protein Methyltransf_32 PF13679.6 CDI83561.1 - 1.6 8.7 18.0 0.59 10.1 3.1 3.4 3 0 0 3 3 3 0 Methyltransferase domain V_ATPase_I PF01496.19 CDI83561.1 - 2.4 5.9 18.5 0.086 10.8 2.0 3.0 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family OATP PF03137.20 CDI83561.1 - 2.5 6.3 12.4 0.34 9.1 0.3 3.0 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family vMSA PF00695.19 CDI83561.1 - 3 6.9 6.8 5.5 6.0 6.8 1.4 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus EOS1 PF12326.8 CDI83561.1 - 5.3 6.9 13.4 11 6.0 0.1 2.9 2 1 0 2 2 2 0 N-glycosylation protein DUF1980 PF09323.10 CDI83561.1 - 6.1 6.7 12.1 3 7.7 0.5 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) FAM176 PF14851.6 CDI83561.1 - 6.9 6.3 14.9 0.95 9.1 0.3 3.9 4 0 0 4 4 4 0 FAM176 family MDM10 PF12519.8 CDI83561.1 - 8.3 5.2 14.3 4 6.2 2.9 2.3 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Myc_N PF01056.18 CDI83562.1 - 0.012 15.6 16.5 0.012 15.6 16.5 3.6 2 1 2 4 4 4 0 Myc amino-terminal region NOA36 PF06524.12 CDI83562.1 - 2.3 7.5 19.2 4.3 6.6 19.2 1.3 1 0 0 1 1 1 0 NOA36 protein Put_DNA-bind_N PF06971.13 CDI83562.1 - 4.9 7.2 7.4 3.2 7.8 0.3 4.2 3 0 0 3 3 3 0 Putative DNA-binding protein N-terminus PBP1_TM PF14812.6 CDI83562.1 - 6.5 7.2 9.9 14 6.2 9.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TIP49 PF06068.13 CDI83564.1 - 8.2e-92 308.1 0.1 9.6e-92 307.9 0.1 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain Alpha-mann_mid PF09261.11 CDI83565.1 - 0.16 12.1 1.3 2.1 8.5 1.0 2.6 2 1 0 2 2 2 0 Alpha mannosidase middle domain TERB2 PF15101.6 CDI83567.1 - 0.0018 18.4 5.9 0.0018 18.4 5.9 5.2 5 1 1 6 6 6 2 Telomere-associated protein TERB2 SR-25 PF10500.9 CDI83568.1 - 0.0023 17.6 5.6 0.0033 17.1 5.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TCP PF03634.13 CDI83568.1 - 0.047 14.2 9.2 0.056 14.0 9.2 1.1 1 0 0 1 1 1 0 TCP family transcription factor MMR1 PF08505.10 CDI83568.1 - 0.053 13.8 12.1 0.062 13.6 12.1 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Coilin_N PF15862.5 CDI83568.1 - 0.74 9.6 11.7 2.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Coilin N-terminus TFIIA PF03153.13 CDI83568.1 - 0.98 9.3 23.7 1 9.3 23.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI83568.1 - 1.3 7.7 10.6 1.4 7.6 10.6 1.1 1 0 0 1 1 1 0 Presenilin STAC2_u1 PF16664.5 CDI83568.1 - 1.5 9.3 11.3 1.9 8.9 11.3 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Ndc1_Nup PF09531.10 CDI83568.1 - 1.6 7.3 10.1 1.7 7.2 10.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hydin_ADK PF17213.3 CDI83568.1 - 1.8 8.8 10.1 2.2 8.5 10.1 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF4407 PF14362.6 CDI83568.1 - 2.1 7.6 9.1 2.4 7.4 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pex14_N PF04695.13 CDI83568.1 - 6.7 7.3 18.6 9.2 6.9 18.6 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Utp14 PF04615.13 CDI83570.1 - 0.0068 15.0 25.8 1.7 7.1 0.0 2.5 2 1 0 2 2 2 2 Utp14 protein ANAPC4_WD40 PF12894.7 CDI83570.1 - 0.074 13.4 0.0 0.57 10.5 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDI83570.1 - 0.1 13.5 0.0 0.51 11.3 0.0 2.3 1 0 0 1 1 1 0 WD domain, G-beta repeat Consortin_C PF15281.6 CDI83570.1 - 8.2 6.5 7.6 11 6.1 0.1 3.6 3 0 0 3 3 3 0 Consortin C-terminus KASH_CCD PF14662.6 CDI83571.1 - 0.0079 16.0 1.0 0.0079 16.0 1.0 2.7 2 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH YabA PF06156.13 CDI83571.1 - 0.06 14.0 25.6 0.084 13.5 4.5 3.9 1 1 3 4 4 4 0 Initiation control protein YabA Atg14 PF10186.9 CDI83571.1 - 0.65 9.0 31.0 0.21 10.7 7.6 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 IMUP PF15761.5 CDI83571.1 - 7.6 7.3 8.9 0.24 12.1 1.5 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein GIT_CC PF16559.5 CDI83571.1 - 7.9 6.4 13.5 2.7 7.9 4.8 3.2 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Ribosomal_L23 PF00276.20 CDI83573.1 - 1.3e-12 47.9 0.0 2.3e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 FluMu_N PF17891.1 CDI83573.1 - 0.001 18.8 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Mu-like prophage FluMu N-terminal domain DUF2722 PF10846.8 CDI83574.1 - 0.0053 15.8 4.1 0.0053 15.8 4.1 5.5 4 2 1 5 5 5 2 Protein of unknown function (DUF2722) Spore_YhcN_YlaJ PF09580.10 CDI83574.1 - 4.1 7.5 19.4 6.9 6.7 0.0 3.4 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Peptidase_C97 PF05903.14 CDI83575.1 - 6.7e-22 78.0 0.0 1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain ADH_zinc_N PF00107.26 CDI83576.1 - 2.6e-06 27.4 0.9 8.4e-06 25.8 0.1 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2722 PF10846.8 CDI83576.1 - 0.0061 15.6 0.1 0.0061 15.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) ADH_N PF08240.12 CDI83576.1 - 0.01 15.7 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Phostensin_N PF13916.6 CDI83576.1 - 0.035 14.4 2.9 0.057 13.8 2.9 1.3 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Spt20 PF12090.8 CDI83576.1 - 0.22 11.1 10.5 0.28 10.8 10.5 1.1 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 CDI83576.1 - 4 6.5 9.7 5.4 6.1 9.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Lyase_1 PF00206.20 CDI83577.1 - 1.6e-42 146.0 0.0 2.1e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C PF08328.11 CDI83577.1 - 0.00031 20.8 0.0 0.00089 19.3 0.0 1.8 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal Ribosomal_S7e PF01251.18 CDI83578.1 - 2e-38 132.0 0.1 2.2e-35 122.1 0.1 2.0 1 1 1 2 2 2 2 Ribosomal protein S7e FtsQ PF03799.15 CDI83578.1 - 0.1 13.4 0.0 0.11 13.3 0.0 1.2 1 0 0 1 1 1 0 Cell division protein FtsQ He_PIG PF05345.12 CDI83580.1 - 0.0046 17.1 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Putative Ig domain Dus PF01207.17 CDI83581.1 - 2e-53 181.5 0.0 5e-53 180.2 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) BKACE PF05853.12 CDI83581.1 - 0.033 13.5 0.2 0.076 12.3 0.2 1.5 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme IP_trans PF02121.18 CDI83582.1 - 4.4e-58 196.8 0.0 6.5e-45 153.6 0.0 2.2 2 0 0 2 2 2 2 Phosphatidylinositol transfer protein Oxysterol_BP PF01237.18 CDI83582.1 - 6.5e-14 51.6 0.0 2.6e-13 49.5 0.0 1.8 2 0 0 2 2 2 1 Oxysterol-binding protein PH PF00169.29 CDI83582.1 - 1e-12 48.5 0.0 2e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CDI83582.1 - 0.00018 21.9 0.0 0.019 15.4 0.0 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain SUIM_assoc PF16619.5 CDI83582.1 - 0.006 16.6 34.2 0.25 11.4 5.1 4.7 4 0 0 4 4 4 3 Unstructured region C-term to UIM in Ataxin3 PH_9 PF15410.6 CDI83582.1 - 0.072 13.5 0.3 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain DUF111 PF01969.17 CDI83582.1 - 2 7.4 3.3 3.3 6.7 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF111 Pro-rich PF15240.6 CDI83582.1 - 2.3 8.5 0.0 2.3 8.5 0.0 8.5 7 2 0 7 7 7 0 Proline-rich Aminotran_1_2 PF00155.21 CDI83583.1 - 3.8e-28 98.7 0.4 8.7e-28 97.5 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II CPSase_sm_chain PF00988.22 CDI83586.1 - 3.6e-34 117.4 0.0 1.2e-33 115.6 0.0 2.0 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CDI83586.1 - 5.8e-21 75.1 0.7 9.9e-21 74.4 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDI83586.1 - 6.1e-06 26.1 0.5 6.1e-06 26.1 0.5 2.3 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 CDI83586.1 - 0.00098 19.0 1.2 0.0023 17.8 0.0 1.8 1 1 1 2 2 2 1 DJ-1/PfpI family DDHD PF02862.17 CDI83586.1 - 0.25 11.5 3.2 2.1 8.5 1.2 2.2 2 0 0 2 2 2 0 DDHD domain TERB2 PF15101.6 CDI83586.1 - 3.3 7.7 7.6 0.71 9.9 3.1 1.9 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF702 PF05142.12 CDI83586.1 - 4.6 7.7 10.0 2.4 8.6 5.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Utp14 PF04615.13 CDI83587.1 - 8.6e-05 21.3 11.1 8.6e-05 21.3 11.1 11.8 6 3 4 11 11 11 1 Utp14 protein RskA PF10099.9 CDI83587.1 - 0.0033 17.8 2.7 0.0033 17.8 2.7 38.4 10 9 14 27 27 27 3 Anti-sigma-K factor rskA IFRD PF05004.13 CDI83588.1 - 0.00064 18.9 0.1 0.00064 18.9 0.1 2.5 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 CDI83588.1 - 0.00076 19.5 0.8 0.054 13.8 0.1 3.5 2 0 0 2 2 2 1 HEAT repeat Pkinase_Tyr PF07714.17 CDI83588.1 - 0.0012 18.2 0.0 0.0029 17.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase SRA1 PF07304.11 CDI83588.1 - 0.14 12.0 3.4 0.35 10.7 3.4 1.7 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) PRIMA1 PF16101.5 CDI83588.1 - 0.18 11.8 4.2 0.72 9.9 4.2 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SPX PF03105.19 CDI83588.1 - 0.85 9.5 7.2 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 SPX domain zf-HC5HC2H_2 PF13832.6 CDI83589.1 - 1.8e-12 47.4 10.1 1.8e-12 47.4 10.1 2.7 2 2 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CDI83589.1 - 2.7e-12 46.8 9.6 2.7e-12 46.8 9.6 2.8 2 1 0 2 2 2 1 PHD-like zinc-binding domain PHD PF00628.29 CDI83589.1 - 6.3e-11 42.0 6.8 6.3e-11 42.0 6.8 3.5 4 0 0 4 4 4 2 PHD-finger PHD_2 PF13831.6 CDI83589.1 - 1.1e-09 37.7 2.0 1.1e-09 37.7 2.0 3.2 3 0 0 3 3 3 2 PHD-finger Prok-RING_1 PF14446.6 CDI83589.1 - 0.00015 21.6 4.0 0.00015 21.6 4.0 3.1 3 1 0 3 3 3 1 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 CDI83589.1 - 0.0027 17.4 0.8 0.0027 17.4 0.8 3.2 2 2 1 3 3 3 1 PHD/FYVE-zinc-finger like domain C1_2 PF03107.16 CDI83589.1 - 0.049 13.9 1.8 0.049 13.9 1.8 3.5 3 0 0 3 3 3 0 C1 domain dsRBD2 PF17842.1 CDI83589.1 - 0.17 12.1 0.0 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 C1_1 PF00130.22 CDI83589.1 - 6.8 6.7 18.4 0.099 12.5 0.8 3.7 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Utp21 PF04192.12 CDI83590.1 - 3.4e-31 108.5 5.3 3.4e-31 108.5 5.3 2.3 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 CDI83590.1 - 4.4e-09 36.8 3.2 0.2 12.6 0.1 7.2 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI83590.1 - 1.3e-08 35.0 0.0 1.4 9.3 0.0 6.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_60s PF00428.19 CDI83590.1 - 0.0041 17.7 7.8 0.0041 17.7 7.8 6.4 6 0 0 6 6 6 2 60s Acidic ribosomal protein RAB3GAP2_N PF14655.6 CDI83590.1 - 0.039 13.2 1.9 0.097 11.9 1.4 1.9 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Velvet PF11754.8 CDI83590.1 - 0.064 13.2 4.2 0.22 11.5 0.8 2.4 2 0 0 2 2 2 0 Velvet factor Frtz PF11768.8 CDI83590.1 - 0.077 11.3 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz TFIIA PF03153.13 CDI83590.1 - 0.11 12.5 21.3 0.25 11.3 13.2 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EPL1 PF10513.9 CDI83590.1 - 0.25 11.7 10.8 1.3 9.4 1.2 3.1 3 0 0 3 3 3 0 Enhancer of polycomb-like FAM60A PF15396.6 CDI83590.1 - 0.48 10.4 11.3 3.5 7.6 1.8 3.3 3 0 0 3 3 3 0 Protein Family FAM60A DUF4569 PF15133.6 CDI83590.1 - 0.67 9.6 12.1 5.6 6.6 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) BAF1_ABF1 PF04684.13 CDI83590.1 - 1.2 8.1 18.9 0.2 10.7 1.6 3.0 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor Spt20 PF12090.8 CDI83590.1 - 5.1 6.6 22.6 2.1 7.9 14.2 2.4 2 0 0 2 2 2 0 Spt20 family Connexin PF00029.19 CDI83590.1 - 5.6 6.6 7.6 21 4.8 0.0 2.9 3 0 0 3 3 3 0 Connexin DUF2722 PF10846.8 CDI83590.1 - 6.5 5.6 25.4 0.27 10.1 13.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF1018 PF06252.12 CDI83593.1 - 0.77 10.8 8.7 0.31 12.0 5.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) DUF641 PF04859.12 CDI83593.1 - 9.3 6.6 21.6 7 7.0 0.3 3.8 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) CS PF04969.16 CDI83594.1 - 5.9e-15 56.0 0.0 1.1e-14 55.2 0.0 1.5 1 0 0 1 1 1 1 CS domain Nudc_N PF14050.6 CDI83594.1 - 8.7e-12 44.8 0.3 1.9e-11 43.8 0.3 1.5 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. Neur_chan_memb PF02932.16 CDI83594.1 - 1.6 8.7 5.7 0.35 10.9 1.5 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Lsr2 PF11774.8 CDI83594.1 - 2 8.6 8.6 0.74 10.0 5.5 1.9 2 0 0 2 2 2 0 Lsr2 WASH-7_C PF14746.6 CDI83594.1 - 4.5 6.9 10.8 0.18 11.5 4.7 1.7 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal Plasmodium_Vir PF05795.11 CDI83594.1 - 5.8 6.2 9.5 0.63 9.4 4.9 1.6 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Presenilin PF01080.17 CDI83594.1 - 7.5 5.2 15.3 0.63 8.7 10.9 1.5 2 0 0 2 2 2 0 Presenilin Activator_LAG-3 PF11498.8 CDI83594.1 - 9.2 5.1 25.0 19 4.1 19.8 2.2 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Herpes_pp85 PF04637.12 CDI83595.1 - 5.8 5.2 9.5 9.4 4.5 2.8 2.4 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) UPF0231 PF06062.11 CDI83595.1 - 5.9 7.2 6.4 0.44 10.8 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0231) Sec16 PF12932.7 CDI83595.1 - 8.5 7.0 6.2 3.1 8.4 1.4 2.8 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region UPF0016 PF01169.19 CDI83596.1 - 1.8e-23 82.7 11.9 2.3e-14 53.5 5.6 2.9 2 1 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF2076 PF09849.9 CDI83596.1 - 0.016 15.3 0.4 5.4 7.0 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) RNase_H2_suC PF08615.11 CDI83597.1 - 2.2e-11 44.1 0.0 7.7e-11 42.3 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Oxidored-like PF09791.9 CDI83598.1 - 0.0053 16.4 0.0 0.0078 15.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Peptidase_S24 PF00717.23 CDI83599.1 - 1.5e-08 34.4 0.1 2.3e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like YL1 PF05764.13 CDI83600.1 - 0.014 15.5 21.9 0.02 15.0 21.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Presenilin PF01080.17 CDI83600.1 - 0.055 12.2 10.8 0.076 11.8 10.8 1.2 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI83600.1 - 0.44 10.6 6.3 0.74 9.8 6.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SDA1 PF05285.12 CDI83600.1 - 0.45 9.9 26.6 0.82 9.0 26.6 1.4 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CDI83600.1 - 1.2 7.2 24.8 1.6 6.9 24.8 1.1 1 0 0 1 1 1 0 Nop14-like family LAP1C PF05609.12 CDI83600.1 - 1.9 7.5 18.8 2.4 7.1 18.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Apt1 PF10351.9 CDI83600.1 - 2 7.1 11.5 2.7 6.7 11.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDI83600.1 - 2.8 6.4 10.0 3.1 6.3 10.0 1.0 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 CDI83600.1 - 5.2 5.1 12.1 6.5 4.7 12.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 CDI83600.1 - 5.6 5.7 6.9 7.5 5.3 6.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Cyclin_C PF02984.19 CDI83603.1 - 0.0034 17.5 1.5 0.0077 16.3 0.2 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain HEAT PF02985.22 CDI83604.1 - 0.56 10.6 34.3 6.7 7.3 0.1 9.0 9 0 0 9 9 9 0 HEAT repeat Vac14_Fab1_bd PF12755.7 CDI83604.1 - 2.8 8.6 6.4 1.3 9.7 0.1 3.6 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region DUF4667 PF15700.5 CDI83604.1 - 3.1 7.9 26.3 0.089 12.9 7.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) DUF755 PF05501.11 CDI83605.1 - 0.015 15.5 20.4 0.015 15.5 20.4 5.8 6 0 0 6 6 6 0 Domain of unknown function (DUF755) CTP_transf_1 PF01148.20 CDI83606.1 - 7.7e-31 107.8 4.2 9e-31 107.6 4.2 1.0 1 0 0 1 1 1 1 Cytidylyltransferase family Kelch_3 PF13415.6 CDI83607.1 - 2e-07 31.1 1.6 0.0052 17.0 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.6 CDI83607.1 - 1.4e-05 25.0 0.1 0.85 9.7 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI83607.1 - 0.00096 19.0 4.1 0.049 13.6 1.2 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 CDI83607.1 - 0.0035 17.3 0.1 0.37 10.8 0.3 2.8 2 0 0 2 2 2 1 Kelch motif Apt1 PF10351.9 CDI83607.1 - 0.056 12.3 4.7 0.077 11.8 4.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF2464 PF10240.9 CDI83607.1 - 0.18 11.3 0.1 15 5.0 0.0 2.0 2 0 0 2 2 2 0 Multivesicular body subunit 12 Kelch_5 PF13854.6 CDI83608.1 - 2.8e-24 84.6 0.1 5.3e-08 32.7 0.0 5.1 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 CDI83608.1 - 2.4e-20 71.8 0.0 6e-06 25.8 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 CDI83608.1 - 7e-19 67.6 3.1 5.8e-08 32.6 0.0 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI83608.1 - 1.7e-18 65.8 2.9 5.6e-06 26.1 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 CDI83608.1 - 4e-18 65.2 7.8 1.6e-06 28.2 0.0 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 CDI83608.1 - 7.7e-13 48.2 0.2 0.00062 20.0 0.0 4.6 4 0 0 4 4 4 3 Kelch motif TFIIA PF03153.13 CDI83608.1 - 1.5 8.7 43.6 1.6 8.6 29.6 2.4 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Sin_N PF04801.13 CDI83608.1 - 3.6 6.7 18.8 6 6.0 18.8 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region CN_hydrolase PF00795.22 CDI83609.1 - 4.2e-26 91.8 0.0 6.1e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 CDI83609.1 - 8.8e-26 90.5 0.0 8.2e-14 51.3 0.0 3.2 3 0 0 3 3 3 3 NAD synthase SUIM_assoc PF16619.5 CDI83609.1 - 0.0013 18.7 0.0 0.09 12.9 0.0 3.0 3 1 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 BRX_assoc PF16627.5 CDI83609.1 - 0.042 14.0 0.0 0.26 11.4 0.0 2.3 2 0 0 2 2 2 0 Unstructured region between BRX_N and BRX domain Kelch_1 PF01344.25 CDI83610.1 - 2e-63 209.8 0.1 4.5e-13 48.5 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 CDI83610.1 - 4.5e-46 153.7 0.2 4.9e-09 36.2 0.0 6.4 3 2 3 6 6 6 6 Kelch motif Kelch_4 PF13418.6 CDI83610.1 - 6.1e-31 106.2 0.2 7.7e-07 29.0 0.0 6.7 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI83610.1 - 2.2e-22 78.8 1.1 0.0016 18.7 0.0 6.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 CDI83610.1 - 2.8e-20 71.5 1.0 0.0043 17.0 0.0 6.9 6 0 0 6 6 6 5 Kelch motif BTB_2 PF02214.22 CDI83610.1 - 1.5e-12 47.7 0.0 3.8e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.6 CDI83610.1 - 4.5e-12 45.7 4.1 0.026 14.5 0.0 6.2 6 0 0 6 6 6 3 Kelch motif DUF1668 PF07893.13 CDI83610.1 - 0.017 14.5 0.0 0.073 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) DUF1918 PF08940.11 CDI83610.1 - 0.064 12.9 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) FapA PF03961.13 CDI83610.1 - 2.4 6.7 9.1 3.7 6.0 9.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Amidase PF01425.21 CDI83611.1 - 0.031 13.2 0.5 0.065 12.2 0.5 1.4 1 0 0 1 1 1 0 Amidase Trypan_PARP PF05887.11 CDI83611.1 - 0.16 12.0 29.8 0.32 11.0 23.6 2.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) AP2 PF00847.20 CDI83613.1 - 1.1e-07 32.0 0.1 5e-06 26.7 0.1 4.5 6 0 0 6 6 6 2 AP2 domain MCM PF00493.23 CDI83616.1 - 2.7e-85 285.0 0.7 4e-85 284.5 0.3 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_lid PF17855.1 CDI83616.1 - 3e-26 91.7 2.7 5.6e-26 90.8 2.7 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 CDI83616.1 - 1.8e-07 30.7 0.1 1.8e-06 27.5 0.1 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDI83616.1 - 0.001 18.9 0.0 0.0028 17.5 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDI83616.1 - 0.0067 16.4 0.0 0.017 15.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CDI83616.1 - 0.0092 16.2 0.7 0.023 14.9 0.7 1.6 1 0 0 1 1 1 1 Midasin AAA lid domain Sigma54_activat PF00158.26 CDI83616.1 - 0.054 13.2 0.0 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 CDI83616.1 - 0.066 13.6 0.0 0.24 11.8 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BAG PF02179.16 CDI83616.1 - 0.14 12.6 3.9 0.23 11.9 1.1 2.5 2 1 0 2 2 2 0 BAG domain EMG1 PF03587.14 CDI83617.1 - 3.1e-15 56.3 0.3 6.2e-08 32.5 0.6 3.6 2 1 0 2 2 2 2 EMG1/NEP1 methyltransferase SUIM_assoc PF16619.5 CDI83617.1 - 0.016 15.3 2.9 0.016 15.3 2.9 7.8 7 1 0 8 8 8 0 Unstructured region C-term to UIM in Ataxin3 SelK_SelG PF10961.8 CDI83618.1 - 0.15 12.7 0.1 0.15 12.7 0.1 2.9 3 0 0 3 3 3 0 Selenoprotein SelK_SelG RR_TM4-6 PF06459.12 CDI83618.1 - 1 9.1 24.6 0.15 11.9 19.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CDI83621.1 - 5.3 5.9 24.8 2.2 7.2 8.1 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Phosphorylase PF00343.20 CDI83622.1 - 3.1e-272 905.1 0.0 3.6e-272 904.8 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase EGF_CA PF07645.15 CDI83624.1 - 4.4e-227 734.1 509.7 2.5e-12 46.8 10.6 33.8 32 1 1 33 33 33 27 Calcium-binding EGF domain EGF_3 PF12947.7 CDI83624.1 - 1.1e-150 489.5 537.6 2.4e-10 40.4 14.5 33.1 33 0 0 33 33 33 29 EGF domain cEGF PF12662.7 CDI83624.1 - 1.3e-134 437.5 309.3 1.6e-08 34.3 4.1 32.7 32 0 0 32 32 32 29 Complement Clr-like EGF-like hEGF PF12661.7 CDI83624.1 - 1.6e-68 225.2 333.9 4.1e-05 24.0 5.3 32.2 30 0 0 30 30 30 28 Human growth factor-like EGF EGF PF00008.27 CDI83624.1 - 1.4e-60 201.1 432.8 7.3e-06 26.2 6.7 31.8 32 0 0 32 32 32 27 EGF-like domain EGF_MSP1_1 PF12946.7 CDI83624.1 - 4.3e-43 145.1 383.4 2.2e-05 24.4 6.5 32.4 32 0 0 32 32 32 23 MSP1 EGF domain 1 FXa_inhibition PF14670.6 CDI83624.1 - 1e-30 105.7 461.4 0.0018 18.5 5.6 32.1 25 5 5 30 30 30 23 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 CDI83624.1 - 1.8e-24 85.8 400.5 0.0011 19.3 7.6 31.7 32 0 0 32 32 32 21 Pvs28 EGF domain Cadherin_5 PF17892.1 CDI83624.1 - 0.22 11.5 5.2 1.1e+02 2.8 0.0 6.0 8 0 0 8 8 8 0 Cadherin-like domain DUF2076 PF09849.9 CDI83624.1 - 0.62 10.1 7.3 1 9.3 7.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Thioredoxin PF00085.20 CDI83627.1 - 0.00033 20.6 0.0 0.076 13.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 CDI83627.1 - 0.0052 16.2 0.0 0.79 9.0 0.0 2.6 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 CDI83627.1 - 0.13 12.3 0.0 2.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain Glutaredoxin PF00462.24 CDI83627.1 - 0.14 12.4 0.1 0.48 10.7 0.0 2.0 2 0 0 2 2 2 0 Glutaredoxin DER1 PF04511.15 CDI83629.1 - 3.8e-20 72.6 0.2 5.2e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 Der1-like family LAMTOR PF15454.6 CDI83629.1 - 6.3 7.5 9.6 2.2 9.0 3.8 2.3 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF1645 PF07816.11 CDI83631.1 - 0.0032 18.1 2.4 0.0032 18.1 2.4 11.4 8 2 2 11 11 11 2 Protein of unknown function (DUF1645) Ras PF00071.22 CDI83633.1 - 2e-40 138.0 0.1 2.8e-40 137.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI83633.1 - 1e-16 61.2 0.0 2.5e-16 60.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI83633.1 - 6.8e-07 28.9 0.0 9.6e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDI83633.1 - 0.0002 21.0 0.0 0.00036 20.1 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDI83633.1 - 0.036 13.4 0.0 0.061 12.7 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Mt_ATP-synt_B PF05405.14 CDI83635.1 - 0.011 15.4 2.1 0.011 15.4 2.1 4.6 2 1 1 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF948 PF06103.11 CDI83635.1 - 8.2 6.8 12.6 14 6.0 2.6 4.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) ACDC PF14733.6 CDI83636.1 - 1.7e-17 63.5 0.1 4.3e-17 62.2 0.1 1.7 1 0 0 1 1 1 1 AP2-coincident C-terminal AP2 PF00847.20 CDI83636.1 - 1.7e-07 31.3 0.5 1.7e-07 31.3 0.5 3.6 5 0 0 5 5 5 1 AP2 domain Sigma70_ner PF04546.13 CDI83636.1 - 0.034 14.0 0.3 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region SUZ PF12752.7 CDI83636.1 - 1.4 9.7 16.1 0.067 14.0 3.4 3.8 3 0 0 3 3 3 0 SUZ domain Sterol-sensing PF12349.8 CDI83637.1 - 1.3e-05 25.1 1.1 1.3e-05 25.1 1.1 2.7 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation DUF4667 PF15700.5 CDI83637.1 - 0.017 15.2 0.0 0.017 15.2 0.0 6.5 6 1 0 6 6 6 0 Domain of unknown function (DUF4667) Patched PF02460.18 CDI83637.1 - 1 7.3 25.5 0.045 11.8 0.7 3.4 3 0 0 3 3 3 0 Patched family Hydrolase_4 PF12146.8 CDI83638.1 - 7.2e-17 61.4 2.5 3.3e-07 29.8 0.0 3.2 3 0 0 3 3 3 3 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDI83638.1 - 0.0041 17.8 5.1 0.011 16.3 5.1 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family LD_cluster3 PF18180.1 CDI83638.1 - 0.08 12.6 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster3 family ATP-synt_10 PF05176.14 CDI83639.1 - 0.095 11.9 0.0 1.8 7.7 0.0 2.0 2 0 0 2 2 2 0 ATP10 protein tRNA-synt_His PF13393.6 CDI83640.1 - 2.4e-09 36.9 0.2 5e-09 35.9 0.2 1.5 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CDI83640.1 - 0.008 16.3 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain DUF2153 PF09921.9 CDI83640.1 - 0.015 15.1 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) GHL13 PF14883.6 CDI83640.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 FapA PF03961.13 CDI83642.1 - 1.1 7.8 5.3 1.8 7.1 5.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2052 PF09747.9 CDI83643.1 - 0.0024 18.0 25.3 0.0027 17.9 25.3 1.0 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) DAG_kinase_N PF14513.6 CDI83643.1 - 0.0047 17.1 12.8 0.0063 16.7 12.8 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus SDA1 PF05285.12 CDI83643.1 - 0.0099 15.3 24.0 0.011 15.1 24.0 1.0 1 0 0 1 1 1 1 SDA1 Band_3_cyto PF07565.13 CDI83643.1 - 0.031 14.1 15.2 0.036 13.9 15.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CobT PF06213.12 CDI83643.1 - 0.049 13.0 29.3 0.069 12.5 29.3 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Stevor PF17410.2 CDI83643.1 - 0.057 13.0 0.9 0.072 12.6 0.9 1.0 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF4366 PF14283.6 CDI83643.1 - 0.078 13.0 11.8 0.11 12.5 11.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Trypan_PARP PF05887.11 CDI83643.1 - 0.16 11.9 6.3 0.23 11.4 6.3 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DDHD PF02862.17 CDI83643.1 - 0.2 11.8 13.5 0.21 11.7 13.5 1.1 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.12 CDI83643.1 - 0.24 9.6 21.5 0.27 9.4 21.5 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 CDI83643.1 - 0.34 11.1 18.8 0.43 10.8 18.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Presenilin PF01080.17 CDI83643.1 - 0.39 9.4 20.7 0.43 9.3 20.7 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CDI83643.1 - 0.42 10.6 13.4 0.48 10.4 13.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FRQ PF09421.10 CDI83643.1 - 0.51 8.3 13.4 0.61 8.1 13.4 1.0 1 0 0 1 1 1 0 Frequency clock protein CDC45 PF02724.14 CDI83643.1 - 0.91 7.7 22.7 1.1 7.5 22.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 CDI83643.1 - 1.4 7.8 10.4 1.7 7.5 10.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 CDI83643.1 - 1.7 8.9 23.3 2.1 8.6 23.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 CDI83643.1 - 1.8 7.5 17.6 2 7.3 17.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4045 PF13254.6 CDI83643.1 - 2 8.0 15.3 2.2 7.8 15.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Rrn6 PF10214.9 CDI83643.1 - 2.2 6.7 17.5 2.4 6.5 17.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor V_ATPase_I PF01496.19 CDI83643.1 - 2.2 6.1 20.8 2.7 5.8 20.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Raftlin PF15250.6 CDI83643.1 - 2.8 6.6 16.4 3.1 6.5 16.4 1.0 1 0 0 1 1 1 0 Raftlin MMU163 PF17119.5 CDI83643.1 - 3.7 6.6 11.6 4.5 6.4 11.6 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Cellulose_synt PF03552.14 CDI83643.1 - 4 5.8 6.6 4.4 5.7 6.6 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF4746 PF15928.5 CDI83643.1 - 4.4 6.6 20.4 5.4 6.3 20.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DNA_pol_phi PF04931.13 CDI83643.1 - 6.7 4.7 21.5 7.6 4.5 21.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi ALMT PF11744.8 CDI83643.1 - 7.6 5.2 12.4 8.5 5.1 12.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CRT10 PF08728.10 CDI83643.1 - 7.8 4.5 11.2 8.9 4.3 11.2 1.0 1 0 0 1 1 1 0 CRT10 NOA36 PF06524.12 CDI83643.1 - 7.9 5.7 23.2 10 5.3 23.2 1.1 1 0 0 1 1 1 0 NOA36 protein SID-1_RNA_chan PF13965.6 CDI83643.1 - 8.3 4.7 6.0 9.2 4.5 6.0 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFIIF_alpha PF05793.12 CDI83643.1 - 8.5 4.8 24.9 11 4.5 24.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Peptidase_S64 PF08192.11 CDI83643.1 - 9.6 4.5 13.5 11 4.3 13.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4834 PF16118.5 CDI83644.1 - 0.022 15.7 5.9 0.027 15.4 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TMEM51 PF15345.6 CDI83644.1 - 0.03 14.2 6.3 0.034 14.0 6.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 HA2 PF04408.23 CDI83644.1 - 0.038 14.3 4.0 0.044 14.1 4.0 1.2 1 0 0 1 1 1 0 Helicase associated domain (HA2) RskA PF10099.9 CDI83644.1 - 0.075 13.3 17.2 0.12 12.7 17.2 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF4199 PF13858.6 CDI83644.1 - 0.098 13.1 2.7 0.11 12.9 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) TPP_enzyme_N PF02776.18 CDI83644.1 - 0.11 12.1 6.5 0.13 11.9 6.5 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain eIF-3_zeta PF05091.12 CDI83644.1 - 0.12 11.3 8.8 0.11 11.5 8.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FHIPEP PF00771.20 CDI83644.1 - 0.13 10.8 6.9 0.13 10.7 6.9 1.0 1 0 0 1 1 1 0 FHIPEP family Serinc PF03348.15 CDI83644.1 - 0.2 10.5 2.6 0.2 10.6 2.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) JSRP PF15312.6 CDI83644.1 - 0.21 11.5 2.5 0.31 11.0 2.5 1.3 1 1 0 1 1 1 0 Junctional sarcoplasmic reticulum protein TFIIA PF03153.13 CDI83644.1 - 0.29 11.1 27.9 0.28 11.2 27.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ctr PF04145.15 CDI83644.1 - 0.72 10.5 4.6 0.85 10.2 4.6 1.1 1 0 0 1 1 1 0 Ctr copper transporter family PigN PF04987.14 CDI83644.1 - 1 8.1 3.3 1.1 8.1 3.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Spt20 PF12090.8 CDI83644.1 - 5.6 6.5 37.5 6.7 6.3 37.5 1.1 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI83645.1 - 1.2e-06 27.8 7.6 1.2e-06 27.8 7.6 4.0 4 0 0 4 4 4 2 Protein of unknown function (DUF2722) SPX PF03105.19 CDI83645.1 - 0.00071 19.6 7.2 0.00071 19.6 7.2 3.7 4 0 0 4 4 4 2 SPX domain Nha1_C PF08619.10 CDI83645.1 - 0.0024 17.2 3.2 0.0024 17.2 3.2 4.1 4 0 0 4 4 4 3 Alkali metal cation/H+ antiporter Nha1 C terminus FAM60A PF15396.6 CDI83645.1 - 0.85 9.6 31.0 2.2 8.2 7.7 4.2 4 0 0 4 4 4 0 Protein Family FAM60A Apt1 PF10351.9 CDI83645.1 - 2.3 7.0 28.1 0.35 9.7 10.8 3.3 3 0 0 3 3 3 0 Golgi-body localisation protein domain Catalase-rel PF06628.12 CDI83646.1 - 1.5e-21 76.3 0.3 2e-21 75.9 0.3 1.2 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase PF00199.19 CDI83646.1 - 0.036 13.2 0.0 0.064 12.3 0.0 1.3 1 0 0 1 1 1 0 Catalase Ribosomal_60s PF00428.19 CDI83647.1 - 1.2 9.8 13.7 2.3 8.9 13.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3138 PF11336.8 CDI83647.1 - 1.3 7.6 3.2 1.6 7.2 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Band_3_cyto PF07565.13 CDI83649.1 - 0.89 9.3 6.8 2.5 7.9 6.8 1.7 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MMU163 PF17119.5 CDI83649.1 - 3.2 6.8 11.2 3.5 6.7 9.0 2.1 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis fn3_6 PF17766.1 CDI83650.1 - 0.076 13.2 0.2 22 5.3 0.2 2.9 2 1 0 2 2 2 0 Fibronectin type-III domain MG4 PF17789.1 CDI83650.1 - 0.13 12.4 0.1 0.41 10.8 0.1 1.9 1 0 0 1 1 1 0 Macroglobulin domain MG4 Ephrin_rec_like PF07699.13 CDI83651.1 - 7.3e-06 25.7 31.9 0.038 13.8 2.6 5.6 2 2 4 6 6 6 5 Putative ephrin-receptor like Asparaginase_2 PF01112.18 CDI83651.1 - 0.13 11.3 1.4 0.18 10.8 1.4 1.1 1 0 0 1 1 1 0 Asparaginase NCD3G PF07562.14 CDI83651.1 - 0.37 10.8 11.8 0.43 10.6 0.2 4.1 2 2 1 4 4 4 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 CDI83651.1 - 0.46 10.9 0.2 0.46 10.9 0.2 4.9 3 2 2 6 6 6 0 TNFR/NGFR cysteine-rich region SARS_X4 PF08779.10 CDI83651.1 - 6 7.2 15.0 15 5.9 0.3 3.8 2 1 2 4 4 4 0 SARS coronavirus X4 like RRM_1 PF00076.22 CDI83652.1 - 1.1e-08 34.7 0.0 3e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spt20 PF12090.8 CDI83652.1 - 0.0059 16.3 3.6 0.0059 16.3 3.6 8.6 5 3 0 6 6 6 2 Spt20 family IFRD_C PF04836.12 CDI83655.1 - 0.11 13.1 0.2 0.11 13.1 0.2 5.0 4 1 0 4 4 4 0 Interferon-related protein conserved region OB_MalK PF17912.1 CDI83655.1 - 0.18 12.6 0.1 1.6 9.6 0.1 2.7 1 0 0 1 1 1 0 MalK OB fold domain SelB-wing_2 PF09106.11 CDI83656.1 - 0.36 11.1 0.1 0.36 11.1 0.1 4.1 2 1 2 4 4 4 0 Elongation factor SelB, winged helix DUF4179 PF13786.6 CDI83657.1 - 4 8.0 0.0 4 8.0 0.0 5.4 7 1 0 7 7 7 0 Domain of unknown function (DUF4179) RskA PF10099.9 CDI83659.1 - 0.0011 19.3 0.1 0.0011 19.3 0.1 9.7 3 1 3 6 6 6 3 Anti-sigma-K factor rskA ABA_WDS PF02496.16 CDI83662.1 - 0.16 12.5 0.2 0.67 10.5 0.1 2.0 2 0 0 2 2 2 0 ABA/WDS induced protein CHS5_N PF16892.5 CDI83663.1 - 0.00058 19.8 1.2 0.00062 19.7 0.0 1.6 2 0 0 2 2 2 1 Chitin biosynthesis protein CHS5 N-terminus DUF3006 PF11213.8 CDI83663.1 - 0.00058 20.0 0.0 0.00058 20.0 0.0 1.9 2 1 0 2 2 1 1 Protein of unknown function (DUF3006) FapA PF03961.13 CDI83663.1 - 0.0033 16.1 6.5 0.0035 16.0 6.5 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A Macoilin PF09726.9 CDI83663.1 - 0.034 12.7 20.0 0.044 12.4 20.0 1.1 1 0 0 1 1 1 0 Macoilin family Nha1_C PF08619.10 CDI83663.1 - 0.044 13.0 0.0 0.044 13.0 0.0 2.0 1 1 1 2 2 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus PAT1 PF09770.9 CDI83663.1 - 0.049 11.9 20.9 0.059 11.6 20.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 V_ATPase_I PF01496.19 CDI83663.1 - 0.39 8.6 13.3 0.56 8.0 13.3 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 CDI83663.1 - 0.53 9.0 11.9 0.64 8.7 10.1 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 eIF-3_zeta PF05091.12 CDI83663.1 - 0.63 8.9 17.7 0.93 8.4 17.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 CDI83663.1 - 0.89 9.1 47.3 0.34 10.5 39.6 2.2 2 0 0 2 2 2 0 Spt20 family RR_TM4-6 PF06459.12 CDI83663.1 - 1.1 9.1 14.1 0.38 10.6 11.2 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5321 PF17254.2 CDI83663.1 - 1.1 8.7 20.7 0.025 14.0 14.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5321) LMBR1 PF04791.16 CDI83663.1 - 2.5 6.9 6.7 2.4 7.0 6.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein BORG_CEP PF14957.6 CDI83663.1 - 2.9 9.0 15.4 0.63 11.2 6.9 2.2 2 0 0 2 2 2 0 Cdc42 effector Exonuc_VII_L PF02601.15 CDI83663.1 - 4.4 6.8 17.3 5.9 6.4 17.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TFIIA PF03153.13 CDI83663.1 - 5 7.0 45.0 8.1 6.3 45.0 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI83663.1 - 6 6.8 15.3 3.6 7.6 10.4 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4770 PF15994.5 CDI83663.1 - 6.9 6.9 18.5 1.9 8.7 15.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Pap_E4 PF02711.14 CDI83663.1 - 8.9 7.3 18.5 13 6.8 0.1 2.2 2 0 0 2 2 2 0 E4 protein Dynactin_p62 PF05502.13 CDI83664.1 - 2.5e-06 26.6 11.4 2.5e-06 26.6 11.4 5.4 5 0 0 5 5 5 3 Dynactin p62 family RskA PF10099.9 CDI83664.1 - 0.012 15.9 9.5 0.012 15.9 9.5 8.7 4 3 3 7 7 7 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI83664.1 - 0.026 13.5 0.1 0.026 13.5 0.1 5.3 3 1 2 5 5 5 0 Protein of unknown function (DUF2722) MecA PF05389.12 CDI83664.1 - 1.2 8.7 7.6 1.2 8.7 1.1 3.3 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) PARG_cat PF05028.14 CDI83667.1 - 9.9e-81 271.6 0.0 4.3e-80 269.5 0.0 1.8 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PhdYeFM_antitox PF02604.19 CDI83667.1 - 0.019 14.8 0.1 0.05 13.4 0.0 1.8 2 0 0 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system zf-C2H2_jaz PF12171.8 CDI83668.1 - 3.2e-05 24.1 1.7 6.8e-05 23.0 1.7 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDI83668.1 - 0.00013 22.2 1.9 0.00033 20.9 1.9 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 CDI83668.1 - 0.014 15.2 1.8 0.025 14.4 1.8 1.4 1 0 0 1 1 1 0 U1 zinc finger CBM_48 PF02922.18 CDI83669.1 - 3.5e-08 33.7 0.0 6e-07 29.7 0.0 2.3 1 1 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) AMPK1_CBM PF16561.5 CDI83669.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase SpoIIE PF07228.12 CDI83670.1 - 9.4e-06 25.7 0.0 0.00015 21.7 0.0 2.6 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CDI83670.1 - 5.2e-05 23.0 0.2 0.00028 20.6 0.0 2.2 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C PF00481.21 CDI83670.1 - 0.078 12.6 0.0 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein phosphatase 2C Cohesin_HEAT PF12765.7 CDI83671.1 - 0.16 12.3 1.2 36 4.8 0.3 3.1 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Herpes_UL87 PF03043.14 CDI83671.1 - 1.5 7.2 8.5 11 4.3 3.3 3.4 3 0 0 3 3 3 0 Herpesvirus UL87 family DKCLD PF08068.12 CDI83674.1 - 1.9e-28 98.3 0.1 4.6e-28 97.1 0.1 1.7 1 0 0 1 1 1 1 DKCLD (NUC011) domain TruB_N PF01509.18 CDI83674.1 - 3.9e-21 76.0 0.2 5.8e-19 68.9 0.2 2.6 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 CDI83674.1 - 4.7e-21 74.5 1.2 8.3e-21 73.7 1.2 1.4 1 0 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 CDI83674.1 - 0.00014 21.9 0.0 0.00029 20.9 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain UPF0113 PF03657.13 CDI83674.1 - 0.0037 17.5 0.0 0.0082 16.4 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain Coilin_N PF15862.5 CDI83674.1 - 8.1 6.3 11.0 19 5.1 11.0 1.5 1 0 0 1 1 1 0 Coilin N-terminus Kinesin PF00225.23 CDI83675.1 - 4.3e-90 302.0 0.0 2.6e-88 296.1 0.0 2.8 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CDI83675.1 - 7.6e-26 90.8 0.1 5.3e-25 88.1 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding TFIIA PF03153.13 CDI83675.1 - 0.0029 17.7 13.1 0.0029 17.7 13.1 3.2 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit Ferrochelatase PF00762.19 CDI83676.1 - 4.5e-19 68.7 0.7 1.7e-09 37.2 0.6 2.6 2 1 0 2 2 2 2 Ferrochelatase TFIIA PF03153.13 CDI83676.1 - 0.005 16.9 26.7 0.006 16.6 12.0 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit USP8_interact PF08941.10 CDI83676.1 - 1.4 8.7 7.4 0.11 12.3 1.6 2.0 2 0 0 2 2 2 0 USP8 interacting Macoilin PF09726.9 CDI83676.1 - 1.5 7.3 24.2 3.3 6.1 24.3 1.5 1 1 0 1 1 1 0 Macoilin family Sec23_trunk PF04811.15 CDI83676.1 - 3.4 7.2 6.3 3.1 7.3 3.0 2.2 1 1 0 2 2 2 0 Sec23/Sec24 trunk domain LCE6A PF15858.5 CDI83677.1 - 0.15 12.8 1.0 0.47 11.2 1.0 1.9 1 0 0 1 1 1 0 Late cornified envelope protein 6A family PCI PF01399.27 CDI83678.1 - 5.3e-12 46.2 0.2 1.4e-11 44.8 0.2 1.7 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 CDI83678.1 - 0.14 12.3 2.6 0.71 10.1 0.0 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat Comm PF15957.5 CDI83679.1 - 0.0044 17.4 0.0 0.021 15.2 0.0 2.0 2 0 0 2 2 2 1 Commissureless WD40 PF00400.32 CDI83680.1 - 0.34 11.9 3.3 34 5.5 0.1 4.1 3 0 0 3 3 3 0 WD domain, G-beta repeat Leader_Trp PF08255.11 CDI83680.1 - 0.38 10.8 4.5 1.3 9.2 4.5 2.0 1 0 0 1 1 1 0 Trp-operon Leader Peptide DUF4592 PF15262.6 CDI83680.1 - 5.7 7.6 11.1 1.6 9.4 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4592) SUIM_assoc PF16619.5 CDI83681.1 - 0.025 14.6 10.0 0.3 11.2 1.6 3.4 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI83681.1 - 7.9 6.0 8.6 3.8 7.0 1.4 2.2 2 0 0 2 2 2 0 Spt20 family DUF1189 PF06691.11 CDI83682.1 - 0.099 12.2 0.2 0.19 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Acyl_transf_3 PF01757.22 CDI83682.1 - 5.8 5.9 12.1 0.16 11.0 4.6 2.2 3 1 0 3 3 3 0 Acyltransferase family Spt20 PF12090.8 CDI83683.1 - 0.67 9.5 8.6 0.78 9.3 8.6 1.1 1 0 0 1 1 1 0 Spt20 family ERCC3_RAD25_C PF16203.5 CDI83685.1 - 9.3e-59 198.6 3.4 1.8e-53 181.3 0.4 3.4 2 1 1 3 3 3 2 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CDI83685.1 - 1.9e-15 57.3 0.6 2.7e-14 53.5 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_3 PF13625.6 CDI83685.1 - 1.9e-06 28.1 0.0 0.00014 22.1 0.0 2.9 1 1 1 2 2 2 1 Helicase conserved C-terminal domain Helicase_C PF00271.31 CDI83685.1 - 6.2e-06 26.5 3.5 1.5e-05 25.3 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Evr1_Alr PF04777.13 CDI83687.1 - 8.9e-09 35.7 1.7 1.3e-06 28.8 0.1 3.7 3 1 0 3 3 3 1 Erv1 / Alr family Thioredoxin PF00085.20 CDI83687.1 - 1.1e-06 28.5 0.0 2.5e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 CDI83687.1 - 0.0036 17.4 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CDI83687.1 - 0.0073 16.7 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 CDI83687.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family DUF4106 PF13388.6 CDI83687.1 - 0.12 11.6 0.1 0.19 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) LYTB PF02401.18 CDI83690.1 - 1e-10 41.4 0.1 1.5e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 LytB protein DUF4813 PF16072.5 CDI83690.1 - 7.8 6.1 24.9 9.8 5.7 24.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Activator_LAG-3 PF11498.8 CDI83691.1 - 0.41 9.6 17.8 0.78 8.6 17.8 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 RNA_pol_Rpc4 PF05132.14 CDI83691.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.9 3 2 0 3 3 3 0 RNA polymerase III RPC4 Spt20 PF12090.8 CDI83691.1 - 7.1 6.2 16.2 12 5.4 16.2 1.3 1 0 0 1 1 1 0 Spt20 family MFS_1 PF07690.16 CDI83693.1 - 1.5e-28 99.7 21.7 1.5e-28 99.7 21.7 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDI83693.1 - 9.2e-10 38.0 17.3 1.1e-09 37.7 14.8 2.1 1 1 2 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 CDI83693.1 - 1.4e-06 26.9 2.1 1.4e-06 26.9 2.1 2.6 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2140 PF09911.9 CDI83693.1 - 0.0011 18.5 1.8 0.0086 15.6 0.1 2.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2140) CLN3 PF02487.17 CDI83693.1 - 0.011 14.9 0.2 0.011 14.9 0.2 3.1 2 1 1 4 4 4 0 CLN3 protein Gaa1 PF04114.14 CDI83693.1 - 0.033 13.2 5.6 0.032 13.2 1.6 2.6 2 1 0 2 2 2 0 Gaa1-like, GPI transamidase component SARAF PF06682.12 CDI83693.1 - 0.67 9.5 7.1 1.4 8.4 2.7 2.6 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Ribosomal_60s PF00428.19 CDI83693.1 - 2.8 8.6 9.9 0.14 12.8 3.8 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI83693.1 - 4.1 7.3 29.1 4.4 7.2 16.4 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PSS PF03034.15 CDI83695.1 - 8.9e-74 248.7 15.3 8.9e-74 248.7 15.3 1.6 2 0 0 2 2 2 1 Phosphatidyl serine synthase DUF962 PF06127.11 CDI83695.1 - 0.015 15.4 0.1 3.5 7.8 0.1 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF962) WBP-1 PF11669.8 CDI83695.1 - 0.95 10.1 0.0 0.95 10.1 0.0 3.4 3 0 0 3 3 3 0 WW domain-binding protein 1 Androgen_recep PF02166.16 CDI83695.1 - 8.3 5.1 14.0 0.16 10.8 7.4 1.3 2 0 0 2 2 2 0 Androgen receptor APCDDC PF14921.6 CDI83696.1 - 0.083 12.3 4.7 0.94 8.9 0.0 2.3 1 1 1 2 2 2 0 Adenomatosis polyposis coli down-regulated 1 Zip PF02535.22 CDI83696.1 - 0.37 10.0 6.2 0.45 9.7 6.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 CDI83696.1 - 1.2 9.1 12.7 0.081 12.9 6.6 1.8 2 0 0 2 2 2 0 Protein Family FAM60A NTP_transf_2 PF01909.23 CDI83697.1 - 8e-06 26.1 0.0 1.9e-05 24.9 0.0 1.6 1 1 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 CDI83697.1 - 0.00083 19.5 0.1 0.0039 17.4 0.1 2.2 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 CDI83697.1 - 0.062 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Cys_rich_CPXG PF14255.6 CDI83697.1 - 0.28 11.1 4.8 0.37 10.7 1.3 2.6 2 0 0 2 2 2 0 Cysteine-rich CPXCG TFIIA PF03153.13 CDI83698.1 - 3.9 7.4 8.6 0.2 11.6 3.5 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit HEAT_EZ PF13513.6 CDI83699.1 - 2.9e-06 27.7 49.7 0.007 16.8 3.8 9.4 8 3 1 9 9 9 3 HEAT-like repeat HEAT PF02985.22 CDI83699.1 - 0.0033 17.5 15.2 2.2 8.8 0.6 6.2 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 CDI83699.1 - 0.0051 16.9 0.9 0.019 15.0 0.2 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 NOC3p PF07540.11 CDI83699.1 - 0.17 12.3 0.2 0.17 12.3 0.2 3.4 4 0 0 4 4 4 0 Nucleolar complex-associated protein HEAT_2 PF13646.6 CDI83699.1 - 1.5 9.3 17.1 1.9 8.9 2.7 5.5 5 1 2 7 7 7 0 HEAT repeats AMMECR1 PF01871.17 CDI83702.1 - 6.5e-43 146.2 0.6 1.5e-42 145.1 0.0 2.0 2 1 0 2 2 2 1 AMMECR1 Dermcidin PF15291.6 CDI83702.1 - 0.19 12.3 0.1 0.19 12.3 0.1 2.4 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide XK-related PF09815.9 CDI83702.1 - 0.55 9.2 1.5 1 8.4 1.5 1.4 1 0 0 1 1 1 0 XK-related protein Med15 PF09606.10 CDI83702.1 - 0.57 8.8 40.1 0.82 8.3 40.1 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TMEM51 PF15345.6 CDI83702.1 - 0.77 9.6 14.4 1.1 9.0 3.1 2.5 2 0 0 2 2 2 0 Transmembrane protein 51 EphA2_TM PF14575.6 CDI83702.1 - 1.6 9.6 6.4 33 5.5 0.1 3.1 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Rpp20 PF12328.8 CDI83702.1 - 6.3 6.8 12.5 38 4.2 8.5 2.7 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P TFIIA PF03153.13 CDI83702.1 - 8.9 6.2 51.1 5 7.0 13.3 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Rep_fac-A_C PF08646.10 CDI83703.1 - 1.2e-30 106.2 0.3 2.8e-30 105.0 0.3 1.7 1 0 0 1 1 1 1 Replication factor-A C terminal domain DUF4503 PF14951.6 CDI83703.1 - 6.4e-06 24.9 0.3 6.4e-06 24.9 0.3 1.8 2 0 0 2 2 1 1 Domain of unknown function (DUF4503) REPA_OB_2 PF16900.5 CDI83703.1 - 0.00033 20.5 0.2 0.25 11.3 0.2 4.0 4 0 0 4 4 4 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 CDI83703.1 - 0.00084 19.3 0.1 0.15 12.0 0.0 3.2 2 1 1 3 3 3 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 CDI83703.1 - 0.0049 16.6 0.9 0.011 15.5 0.9 1.5 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 zf-TFIIB PF13453.6 CDI83703.1 - 0.036 13.4 2.1 0.074 12.4 2.1 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger OrfB_Zn_ribbon PF07282.11 CDI83703.1 - 0.093 12.7 0.9 0.29 11.1 0.9 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF866 PF05907.13 CDI83703.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) zinc-ribbons_6 PF07191.12 CDI83703.1 - 0.11 12.5 2.3 0.35 10.9 2.3 1.9 1 0 0 1 1 1 0 zinc-ribbons IBR PF01485.21 CDI83703.1 - 0.11 12.7 1.0 0.3 11.4 1.0 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain RNA_POL_M_15KD PF02150.16 CDI83703.1 - 0.19 11.6 1.0 0.4 10.6 1.0 1.4 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit TIP120 PF08623.10 CDI83709.1 - 6.4e-08 32.6 0.0 6.4e-08 32.6 0.0 3.6 4 0 0 4 4 4 1 TATA-binding protein interacting (TIP20) RskA PF10099.9 CDI83709.1 - 0.031 14.6 0.6 0.031 14.6 0.6 11.9 2 2 6 8 8 8 0 Anti-sigma-K factor rskA HEAT PF02985.22 CDI83709.1 - 0.05 13.9 0.0 0.05 13.9 0.0 8.2 7 0 0 7 7 7 0 HEAT repeat ArsC PF03960.15 CDI83709.1 - 0.18 11.8 0.2 0.73 9.9 0.0 2.2 2 0 0 2 2 2 0 ArsC family Pro-rich PF15240.6 CDI83710.1 - 2.6e-06 27.8 16.1 2.6e-06 27.8 16.1 2.2 2 0 0 2 2 2 1 Proline-rich MecA PF05389.12 CDI83710.1 - 0.00073 19.2 2.3 0.0014 18.3 2.3 1.4 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) CDC45 PF02724.14 CDI83710.1 - 0.0012 17.2 4.2 0.0012 17.2 4.2 1.4 2 0 0 2 2 2 1 CDC45-like protein DDHD PF02862.17 CDI83710.1 - 0.0017 18.6 3.7 0.0017 18.6 3.7 2.1 2 0 0 2 2 2 1 DDHD domain CTNNB1_binding PF08347.11 CDI83710.1 - 0.0021 18.3 1.9 0.0021 18.3 1.9 2.0 2 0 0 2 2 2 1 N-terminal CTNNB1 binding NPR3 PF03666.13 CDI83710.1 - 0.0041 16.0 4.3 0.0041 16.0 4.3 1.8 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF4746 PF15928.5 CDI83710.1 - 0.007 15.8 4.2 0.01 15.3 4.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) EPL1 PF10513.9 CDI83710.1 - 0.013 15.9 7.4 0.013 15.9 7.4 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like Asp-B-Hydro_N PF05279.11 CDI83710.1 - 0.024 14.7 8.5 0.035 14.2 8.5 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SID-1_RNA_chan PF13965.6 CDI83710.1 - 0.032 12.7 0.0 0.033 12.6 0.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PPL5 PF18168.1 CDI83710.1 - 0.046 13.0 3.8 0.077 12.3 3.8 1.4 1 0 0 1 1 1 0 Prim-pol family 5 DUF5308 PF17233.2 CDI83710.1 - 0.09 13.0 10.3 0.28 11.4 6.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) FHIPEP PF00771.20 CDI83710.1 - 0.27 9.6 2.9 0.34 9.3 2.9 1.1 1 0 0 1 1 1 0 FHIPEP family NST1 PF13945.6 CDI83710.1 - 0.6 10.2 28.4 0.16 12.1 17.9 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF2126 PF09899.9 CDI83710.1 - 0.74 7.8 7.7 1.2 7.2 7.7 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Tim54 PF11711.8 CDI83710.1 - 1.1 8.0 12.1 2 7.1 12.1 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PTPRCAP PF15713.5 CDI83710.1 - 1.2 9.4 18.7 0.26 11.6 14.8 1.8 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Suf PF05843.14 CDI83710.1 - 2 8.3 16.4 0.12 12.3 9.2 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 CDI83710.1 - 2.6 6.6 12.3 0.17 10.5 6.1 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF2052 PF09747.9 CDI83710.1 - 3 7.9 19.9 0.27 11.3 15.0 1.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) TRAP_alpha PF03896.16 CDI83710.1 - 3.2 6.9 8.3 5 6.2 8.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SLC12 PF03522.15 CDI83710.1 - 3.2 6.7 16.5 0.48 9.4 10.5 1.9 2 0 0 2 2 2 0 Solute carrier family 12 CPSF100_C PF13299.6 CDI83710.1 - 3.7 7.7 16.6 0.47 10.6 11.4 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TFB6 PF17110.5 CDI83710.1 - 5.6 6.7 12.0 9.2 6.0 12.0 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Otopetrin PF03189.13 CDI83710.1 - 6.7 5.4 8.5 1.9 7.2 4.4 1.8 2 0 0 2 2 2 0 Otopetrin Gti1_Pac2 PF09729.9 CDI83710.1 - 7.2 6.7 17.3 1.7 8.7 9.6 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family PAT1 PF09770.9 CDI83710.1 - 7.5 4.7 23.1 0.12 10.6 16.0 1.5 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 CDI83710.1 - 7.9 6.3 37.0 0.2 11.6 23.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI83710.1 - 8 6.4 16.0 0.95 9.4 9.3 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Paramyxo_ncap PF00973.19 CDI83710.1 - 9.8 5.0 10.7 17 4.1 10.7 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Rad17 PF03215.15 CDI83711.1 - 0.00099 19.1 0.0 0.0013 18.7 0.0 1.3 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CDI83711.1 - 0.0032 17.9 0.0 0.0042 17.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DNA_pol3_delta2 PF13177.6 CDI83711.1 - 0.07 12.9 0.0 0.086 12.6 0.0 1.3 1 1 0 1 1 1 0 DNA polymerase III, delta subunit DUF815 PF05673.13 CDI83711.1 - 0.1 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CAF1C_H4-bd PF12265.8 CDI83712.1 - 6.2e-18 64.8 0.1 1.5e-17 63.6 0.1 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDI83712.1 - 0.00013 22.6 1.4 3.3 8.7 0.0 4.9 5 1 0 5 5 5 1 WD domain, G-beta repeat Macoilin PF09726.9 CDI83712.1 - 0.019 13.6 5.8 0.025 13.2 5.8 1.1 1 0 0 1 1 1 0 Macoilin family AA_kinase PF00696.28 CDI83712.1 - 0.099 12.2 0.7 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 Amino acid kinase family Presenilin PF01080.17 CDI83712.1 - 0.11 11.3 1.1 0.14 10.9 1.1 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 CDI83712.1 - 0.18 10.6 5.0 0.23 10.3 5.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Menin PF05053.13 CDI83712.1 - 0.26 9.6 7.6 0.4 9.0 7.6 1.2 1 0 0 1 1 1 0 Menin Smg8_Smg9 PF10220.9 CDI83712.1 - 6.5 4.9 5.5 9.1 4.4 5.5 1.1 1 0 0 1 1 1 0 Smg8_Smg9 GREB1 PF15782.5 CDI83712.1 - 7.3 3.6 6.9 9.5 3.2 6.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MACPF PF01823.19 CDI83713.1 - 3.9e-40 138.2 0.0 3.9e-40 138.2 0.0 4.5 4 1 0 4 4 4 1 MAC/Perforin domain 5-FTHF_cyc-lig PF01812.20 CDI83713.1 - 2.8 7.8 6.3 40 4.0 0.9 3.1 3 0 0 3 3 3 0 5-formyltetrahydrofolate cyclo-ligase family DUF3235 PF11574.8 CDI83714.1 - 0.11 13.4 5.3 0.17 12.8 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) HEPN_Swt1 PF18731.1 CDI83714.1 - 0.16 12.3 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Swt1-like HEPN SnoaL PF07366.12 CDI83714.1 - 0.29 10.9 0.7 9.5 6.0 0.0 2.4 3 0 0 3 3 3 0 SnoaL-like polyketide cyclase CENP-O PF09496.10 CDI83715.1 - 0.052 13.5 4.0 0.11 12.5 4.0 1.4 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DotA PF11388.8 CDI83715.1 - 0.056 13.6 0.2 0.056 13.6 0.2 2.2 2 0 0 2 2 2 0 Phagosome trafficking protein DotA Spt20 PF12090.8 CDI83715.1 - 0.086 12.4 12.6 0.17 11.5 12.6 1.4 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI83715.1 - 0.09 12.8 12.7 0.19 11.7 12.7 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit 60KD_IMP PF02096.20 CDI83715.1 - 0.21 11.5 1.6 0.35 10.8 1.6 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein DUF2722 PF10846.8 CDI83715.1 - 0.26 10.2 10.3 0.014 14.4 4.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SKIP_SNW PF02731.15 CDI83715.1 - 0.7 9.5 10.3 1.6 8.4 10.3 1.5 1 0 0 1 1 1 0 SKIP/SNW domain Spc24 PF08286.11 CDI83715.1 - 9.1 6.6 13.9 21 5.4 13.6 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 AP2 PF00847.20 CDI83716.1 - 4.4e-09 36.4 40.6 1.3e-05 25.4 1.9 6.6 6 0 0 6 6 6 4 AP2 domain CENP-F_leu_zip PF10473.9 CDI83717.1 - 0.013 15.5 2.2 0.017 15.1 2.2 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HR1 PF02185.16 CDI83717.1 - 0.23 11.6 4.3 1.5 9.0 4.3 2.1 1 1 0 1 1 1 0 Hr1 repeat DUF3450 PF11932.8 CDI83717.1 - 0.27 10.5 5.9 0.47 9.7 5.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DegQ PF08181.11 CDI83719.1 - 0.093 12.8 1.6 0.11 12.7 0.5 1.6 2 0 0 2 2 2 0 DegQ (SacQ) family PLDc_2 PF13091.6 CDI83722.1 - 2.8e-05 24.0 0.0 0.00021 21.2 0.0 4.0 3 2 0 3 3 3 2 PLD-like domain PLDc PF00614.22 CDI83722.1 - 0.0026 17.9 3.1 0.83 9.9 0.0 3.0 3 0 0 3 3 3 2 Phospholipase D Active site motif DUF4820 PF16091.5 CDI83722.1 - 0.48 9.8 9.2 1.6 8.0 9.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SLC12 PF03522.15 CDI83722.1 - 1.4 7.9 8.9 2.7 6.9 8.9 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_M16 PF00675.20 CDI83724.1 - 2.9e-21 76.0 0.0 2.9e-21 76.0 0.0 3.2 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 CDI83724.1 - 2.3e-06 27.1 0.0 6.7e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Allexi_40kDa PF05549.11 CDI83724.1 - 3.3 7.2 7.1 9.8 5.6 7.1 1.8 1 0 0 1 1 1 0 Allexivirus 40kDa protein Telomere_Sde2_2 PF13297.6 CDI83725.1 - 0.027 14.1 0.2 0.094 12.4 0.0 2.0 2 0 0 2 2 2 0 Telomere stability C-terminal SPG4 PF17325.2 CDI83725.1 - 0.034 15.2 1.1 0.034 15.2 1.1 4.8 4 1 1 5 5 5 0 Stationary phase protein 4 TIM PF00121.18 CDI83726.1 - 9.9e-59 198.6 0.3 6.9e-54 182.8 0.0 2.0 1 1 1 2 2 2 2 Triosephosphate isomerase DUF1800 PF08811.11 CDI83726.1 - 0.067 12.2 0.2 0.085 11.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) MT-A70 PF05063.14 CDI83727.1 - 7.3e-57 192.0 0.4 7.3e-57 192.0 0.4 2.7 2 0 0 2 2 2 1 MT-A70 LRR_4 PF12799.7 CDI83727.1 - 1.3e-11 44.5 20.0 0.00047 20.5 0.0 4.9 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LMBR1 PF04791.16 CDI83727.1 - 0.00017 20.7 2.6 0.00017 20.7 2.6 5.6 3 2 0 4 4 4 1 LMBR1-like membrane protein SUIM_assoc PF16619.5 CDI83728.1 - 0.00016 21.6 0.0 0.00016 21.6 0.0 17.2 12 4 2 14 14 14 3 Unstructured region C-term to UIM in Ataxin3 SR-25 PF10500.9 CDI83728.1 - 0.013 15.1 0.2 0.013 15.1 0.2 10.4 8 2 0 8 8 8 0 Nuclear RNA-splicing-associated protein zf-C3HC4_3 PF13920.6 CDI83728.1 - 1.7 8.5 40.4 0.029 14.2 18.6 4.2 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 CDI83729.1 - 3.7e-06 27.6 6.9 0.033 15.1 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat SMAP PF15477.6 CDI83729.1 - 0.56 11.2 2.2 35 5.4 0.1 2.7 2 0 0 2 2 2 0 Small acidic protein family Sad1_UNC PF07738.13 CDI83732.1 - 8.5e-14 51.7 0.0 1.8e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Rft-1 PF04506.13 CDI83733.1 - 8.6e-17 61.1 1.5 1.6e-07 30.5 0.5 2.4 2 1 0 2 2 2 2 Rft protein AP2 PF00847.20 CDI83734.1 - 3.1e-10 40.1 4.1 3.1e-10 40.1 4.1 3.0 2 0 0 2 2 2 1 AP2 domain DUF2722 PF10846.8 CDI83734.1 - 0.00021 20.4 2.1 0.00021 20.4 2.1 5.4 5 0 0 5 5 5 3 Protein of unknown function (DUF2722) DUF3682 PF12446.8 CDI83734.1 - 0.0012 19.3 10.7 0.0012 19.3 10.7 15.2 9 3 4 14 14 14 1 Protein of unknown function (DUF3682) IR1-M PF12185.8 CDI83734.1 - 0.018 14.9 0.8 0.077 12.9 0.8 2.1 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain Ras PF00071.22 CDI83735.1 - 5.2e-11 42.4 0.0 7.6e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Ras PF00071.22 CDI83736.1 - 9.7e-12 44.8 0.0 1.2e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI83736.1 - 2e-11 44.2 1.4 2.3e-11 43.9 1.4 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 CDI83736.1 - 0.00069 20.1 0.8 0.00099 19.6 0.8 1.2 1 0 0 1 1 1 1 ABC transporter Septin PF00735.18 CDI83736.1 - 0.00095 18.5 0.5 0.0011 18.3 0.5 1.1 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 CDI83736.1 - 0.0011 19.4 1.9 0.0016 18.9 1.9 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CDI83736.1 - 0.0021 17.6 0.6 0.0025 17.4 0.6 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 CDI83736.1 - 0.0025 17.0 0.1 0.0034 16.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TniB PF05621.11 CDI83736.1 - 0.004 16.6 0.4 0.01 15.2 0.3 1.7 1 1 0 1 1 1 1 Bacterial TniB protein AAA_22 PF13401.6 CDI83736.1 - 0.0076 16.5 1.0 0.017 15.4 1.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI83736.1 - 0.0092 15.7 0.3 0.017 14.9 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDI83736.1 - 0.0097 15.8 4.3 0.023 14.6 4.3 1.7 1 1 0 1 1 1 1 RsgA GTPase RskA PF10099.9 CDI83736.1 - 0.017 15.4 2.8 0.019 15.3 2.8 1.0 1 0 0 1 1 1 0 Anti-sigma-K factor rskA MMR_HSR1 PF01926.23 CDI83736.1 - 0.018 15.1 0.0 0.03 14.4 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_5 PF07728.14 CDI83736.1 - 0.019 15.0 0.2 0.021 14.8 0.2 1.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.10 CDI83736.1 - 0.02 14.3 0.1 0.023 14.1 0.1 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MCM PF00493.23 CDI83736.1 - 0.028 13.5 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 CDI83736.1 - 0.036 13.8 0.0 0.036 13.8 0.0 2.0 1 1 1 2 2 2 0 AAA domain DUF4834 PF16118.5 CDI83736.1 - 0.13 13.3 4.0 0.13 13.2 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Spt20 PF12090.8 CDI83736.1 - 2.2 7.9 27.4 2.4 7.7 27.4 1.1 1 0 0 1 1 1 0 Spt20 family UPF0560 PF10577.9 CDI83736.1 - 6.3 5.2 13.4 6.6 5.1 13.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Hpr_kinase_C PF07475.12 CDI83736.1 - 7.8 6.0 7.5 0.45 10.0 0.2 1.9 1 1 1 2 2 2 0 HPr Serine kinase C-terminal domain Spt20 PF12090.8 CDI83737.1 - 8.9 5.8 16.6 1.9 8.1 5.1 2.4 2 0 0 2 2 2 0 Spt20 family RskA PF10099.9 CDI83739.1 - 0.00087 19.6 3.9 0.00087 19.6 3.9 5.2 4 1 1 5 5 5 3 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI83739.1 - 0.0046 16.0 47.8 0.0064 15.5 4.1 4.3 4 1 0 4 4 4 3 Protein of unknown function (DUF2722) Roughex PF06020.11 CDI83739.1 - 0.41 9.7 28.9 0.9 8.6 6.9 3.4 3 0 0 3 3 3 0 Drosophila roughex protein GWT1 PF06423.12 CDI83739.1 - 1.2 9.3 5.3 1.3 9.2 0.6 2.8 3 0 0 3 3 3 0 GWT1 Mit_KHE1 PF10173.9 CDI83739.1 - 1.5 8.8 4.8 20 5.2 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related PIP5K PF01504.18 CDI83739.1 - 4 6.6 15.0 0.11 11.6 0.9 2.4 2 1 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase EphA2_TM PF14575.6 CDI83739.1 - 5 8.1 15.8 3.5 8.6 0.3 3.8 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain NEMP PF10225.9 CDI83739.1 - 5.1 6.7 9.5 0.99 9.0 1.0 2.8 3 0 0 3 3 3 0 NEMP family Gaa1 PF04114.14 CDI83739.1 - 5.4 5.9 12.0 1.3 8.0 2.7 3.0 3 0 0 3 3 3 0 Gaa1-like, GPI transamidase component 2OG-FeII_Oxy_2 PF13532.6 CDI83740.1 - 2.8e-07 30.9 0.0 2.8e-07 30.9 0.0 7.4 9 0 0 9 9 9 1 2OG-Fe(II) oxygenase superfamily SR-25 PF10500.9 CDI83740.1 - 0.0005 19.8 2.6 0.0005 19.8 2.6 15.7 9 2 9 18 18 18 5 Nuclear RNA-splicing-associated protein RCC1 PF00415.18 CDI83741.1 - 9.9e-19 67.7 18.3 3.6e-09 37.1 0.5 4.8 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI83741.1 - 0.00089 19.0 22.1 0.22 11.4 0.3 5.3 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat DUF2722 PF10846.8 CDI83741.1 - 0.08 11.9 42.0 0.13 11.2 7.0 5.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2722) Suf PF05843.14 CDI83743.1 - 0.0066 16.5 11.7 0.0068 16.4 11.7 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) PAT1 PF09770.9 CDI83743.1 - 0.0067 14.8 19.9 0.0063 14.9 19.9 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 CDI83743.1 - 0.0082 15.9 7.1 0.0098 15.7 7.1 1.1 1 0 0 1 1 1 1 Connexin Presenilin PF01080.17 CDI83743.1 - 0.011 14.5 13.0 0.012 14.4 13.0 1.1 1 0 0 1 1 1 0 Presenilin Paramyxo_ncap PF00973.19 CDI83743.1 - 0.011 14.6 10.3 0.013 14.5 10.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein RR_TM4-6 PF06459.12 CDI83743.1 - 0.014 15.2 9.1 0.014 15.3 9.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SID-1_RNA_chan PF13965.6 CDI83743.1 - 0.018 13.4 0.5 0.02 13.3 0.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DDHD PF02862.17 CDI83743.1 - 0.021 15.0 8.9 0.023 14.8 8.9 1.1 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 CDI83743.1 - 0.022 14.8 36.1 0.035 14.1 36.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Serinc PF03348.15 CDI83743.1 - 0.037 13.0 4.4 0.037 13.0 4.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 CDI83743.1 - 0.037 14.1 6.6 0.038 14.1 6.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Rrn6 PF10214.9 CDI83743.1 - 0.043 12.3 15.7 0.042 12.4 15.7 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SLC12 PF03522.15 CDI83743.1 - 0.044 12.8 8.5 0.043 12.8 8.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF1980 PF09323.10 CDI83743.1 - 0.054 13.4 3.3 0.059 13.3 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) EOS1 PF12326.8 CDI83743.1 - 0.085 12.8 3.2 0.089 12.7 3.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein FAM60A PF15396.6 CDI83743.1 - 0.087 12.8 5.6 0.092 12.7 5.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI83743.1 - 0.091 11.7 15.7 0.093 11.7 15.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI83743.1 - 0.092 12.2 14.1 0.11 11.9 14.1 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) MMR1 PF08505.10 CDI83743.1 - 0.13 12.6 13.2 0.14 12.5 13.2 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Velvet PF11754.8 CDI83743.1 - 0.13 12.2 10.1 0.14 12.1 10.1 1.1 1 0 0 1 1 1 0 Velvet factor DUF913 PF06025.12 CDI83743.1 - 0.16 10.9 5.3 0.17 10.9 5.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Het-C PF07217.11 CDI83743.1 - 0.24 9.9 6.7 0.27 9.7 6.7 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF4746 PF15928.5 CDI83743.1 - 0.24 10.8 7.2 0.25 10.7 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Exonuc_VII_L PF02601.15 CDI83743.1 - 0.27 10.8 19.1 0.35 10.4 19.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Band_3_cyto PF07565.13 CDI83743.1 - 0.28 10.9 10.0 0.31 10.8 10.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MMU163 PF17119.5 CDI83743.1 - 0.29 10.2 6.7 0.36 9.9 6.7 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Nop53 PF07767.11 CDI83743.1 - 0.33 10.3 19.0 0.39 10.0 19.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2347 PF09804.9 CDI83743.1 - 0.33 10.5 5.7 0.36 10.4 5.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF1151 PF06625.11 CDI83743.1 - 0.39 10.7 26.1 0.5 10.3 26.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) LMBR1 PF04791.16 CDI83743.1 - 0.43 9.4 3.1 0.35 9.7 3.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Tim54 PF11711.8 CDI83743.1 - 0.44 9.3 12.6 0.62 8.8 12.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1168 PF06658.12 CDI83743.1 - 0.61 9.9 18.6 1.2 9.0 18.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) MAJIN PF15077.6 CDI83743.1 - 0.65 9.8 6.8 0.66 9.7 6.8 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Rxt3 PF08642.10 CDI83743.1 - 0.96 10.2 6.7 1.7 9.4 6.7 1.5 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Eapp_C PF10238.9 CDI83743.1 - 1 9.4 15.2 1.7 8.7 15.2 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein TERB2 PF15101.6 CDI83743.1 - 1 9.3 20.4 1.3 9.0 20.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF3112 PF11309.8 CDI83743.1 - 1.1 8.7 2.3 1.3 8.4 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Hydin_ADK PF17213.3 CDI83743.1 - 1.1 9.5 13.3 1.6 8.9 13.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain OATP PF03137.20 CDI83743.1 - 1.2 7.3 7.3 1.6 7.0 7.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Hid1 PF12722.7 CDI83743.1 - 1.3 7.1 10.9 1.3 7.0 10.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PBP_sp32 PF07222.12 CDI83743.1 - 1.3 8.5 15.2 1.5 8.2 15.2 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CSG2 PF16965.5 CDI83743.1 - 1.3 7.9 6.1 1.7 7.5 6.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator NEMP PF10225.9 CDI83743.1 - 1.4 8.6 3.3 1.4 8.5 3.3 1.2 1 0 0 1 1 1 0 NEMP family Afi1 PF07792.12 CDI83743.1 - 1.6 9.2 13.3 2.2 8.8 13.3 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4638 PF15472.6 CDI83743.1 - 2.1 8.0 13.4 2.5 7.7 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) CLN3 PF02487.17 CDI83743.1 - 2.3 7.2 11.4 3.2 6.7 11.4 1.2 1 0 0 1 1 1 0 CLN3 protein Folate_carrier PF01770.18 CDI83743.1 - 2.3 6.9 7.0 3.4 6.3 7.0 1.2 1 0 0 1 1 1 0 Reduced folate carrier AAA_23 PF13476.6 CDI83743.1 - 2.4 8.6 16.6 2.9 8.3 16.6 1.1 1 0 0 1 1 1 0 AAA domain NARP1 PF12569.8 CDI83743.1 - 2.4 7.0 17.7 3.2 6.6 17.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Ndc1_Nup PF09531.10 CDI83743.1 - 3.2 6.3 10.9 3.3 6.3 10.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HCO3_cotransp PF00955.21 CDI83743.1 - 3.8 6.2 4.5 4.5 6.0 4.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family FAM91_C PF14648.6 CDI83743.1 - 3.8 6.2 9.4 4.9 5.9 9.4 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Peptidase_S15 PF02129.18 CDI83743.1 - 3.9 7.0 16.3 4.8 6.7 16.3 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) MDM10 PF12519.8 CDI83743.1 - 4.4 6.1 13.0 5.4 5.8 13.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4471 PF14740.6 CDI83743.1 - 4.8 6.3 12.9 6.4 5.9 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) DUF2126 PF09899.9 CDI83743.1 - 4.9 5.1 12.2 6.4 4.7 12.2 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) EPL1 PF10513.9 CDI83743.1 - 5.2 7.4 16.8 7.6 6.9 16.8 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like V_ATPase_I PF01496.19 CDI83743.1 - 5.3 4.8 17.2 6.4 4.6 17.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1764 PF08576.10 CDI83743.1 - 5.4 8.0 14.0 9 7.3 14.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Plasmodium_Vir PF05795.11 CDI83743.1 - 6.4 6.1 7.9 6.7 6.0 7.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DDRGK PF09756.9 CDI83743.1 - 7.7 6.1 24.5 9.8 5.7 24.5 1.1 1 0 0 1 1 1 0 DDRGK domain FAM176 PF14851.6 CDI83743.1 - 9 5.9 10.4 13 5.4 10.4 1.2 1 0 0 1 1 1 0 FAM176 family Pkinase PF00069.25 CDI83744.1 - 9.5e-18 64.5 0.0 1.4e-09 37.7 0.1 7.3 6 1 0 6 6 6 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83744.1 - 4.8e-09 35.9 0.0 4.8e-09 35.9 0.0 4.5 4 1 0 4 4 4 1 Protein tyrosine kinase Collagen PF01391.18 CDI83744.1 - 9e-07 28.6 34.3 9e-07 28.6 34.3 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) EF-hand_1 PF00036.32 CDI83744.1 - 0.012 15.1 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 EF hand CDC45 PF02724.14 CDI83746.1 - 0.56 8.4 24.5 0.065 11.5 12.4 2.5 2 0 0 2 2 2 0 CDC45-like protein MFS_1 PF07690.16 CDI83747.1 - 2.2e-17 63.0 34.8 2.5e-17 62.8 30.1 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CDI83747.1 - 1.9e-05 23.2 19.2 0.00074 17.9 3.0 3.0 1 1 2 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Nop PF01798.18 CDI83748.1 - 4.6e-80 268.4 0.2 9.1e-80 267.4 0.2 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CDI83748.1 - 1.7e-13 50.7 0.1 1.7e-13 50.7 0.1 2.5 2 0 0 2 2 2 1 NOP5NT (NUC127) domain AAA_lid_9 PF17871.1 CDI83748.1 - 0.0043 17.0 9.3 0.0044 16.9 7.0 2.3 1 1 0 1 1 1 1 AAA lid domain Cdh1_DBD_1 PF18196.1 CDI83748.1 - 0.018 15.3 9.3 0.063 13.6 9.3 2.0 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 FancD2 PF14631.6 CDI83748.1 - 7.4 3.8 8.3 11 3.2 8.3 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Metallophos PF00149.28 CDI83750.1 - 1.8e-41 142.9 0.1 2.2e-41 142.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDI83750.1 - 9.7e-22 77.2 0.5 2.2e-21 76.0 0.3 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain AP2 PF00847.20 CDI83751.1 - 2.5e-07 30.8 0.8 2.5e-07 30.8 0.8 5.2 3 0 0 3 3 3 1 AP2 domain PhnA_Zn_Ribbon PF08274.12 CDI83751.1 - 0.17 11.8 0.7 0.43 10.6 0.7 1.6 1 0 0 1 1 1 0 PhnA Zinc-Ribbon Kinesin PF00225.23 CDI83753.1 - 3.6e-99 331.9 0.1 3.6e-99 331.9 0.1 3.4 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 CDI83753.1 - 3.7e-22 78.9 0.1 8.5e-19 68.0 0.0 3.0 2 0 0 2 2 2 2 Microtubule binding CAP_GLY PF01302.25 CDI83754.1 - 3.5e-12 46.1 0.4 3.1e-08 33.5 0.1 2.3 2 0 0 2 2 2 2 CAP-Gly domain SpoIIP PF07454.11 CDI83754.1 - 0.21 11.0 22.6 0.027 13.9 11.2 3.1 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 CDI83754.1 - 0.54 8.5 19.7 0.044 12.1 8.3 2.5 2 0 0 2 2 2 0 CDC45-like protein FHIPEP PF00771.20 CDI83754.1 - 0.56 8.6 8.4 0.44 9.0 6.2 1.8 2 0 0 2 2 2 0 FHIPEP family Sec10 PF07393.11 CDI83754.1 - 0.95 7.8 22.4 0.0096 14.4 3.1 2.4 2 0 0 2 2 2 0 Exocyst complex component Sec10 LRR_4 PF12799.7 CDI83754.1 - 1.3 9.6 5.0 1.9 9.0 1.0 3.1 3 1 1 4 4 3 0 Leucine Rich repeats (2 copies) Het-C PF07217.11 CDI83754.1 - 1.5 7.3 7.6 2.7 6.4 7.6 1.3 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Gti1_Pac2 PF09729.9 CDI83754.1 - 1.7 8.7 32.2 2.4 8.2 10.3 3.9 4 0 0 4 4 4 0 Gti1/Pac2 family CPSF100_C PF13299.6 CDI83754.1 - 1.9 8.6 25.3 0.16 12.1 9.0 4.1 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal DUF4746 PF15928.5 CDI83754.1 - 2.2 7.6 10.6 6.2 6.1 10.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) Connexin PF00029.19 CDI83754.1 - 3.2 7.5 17.9 0.58 9.9 11.0 2.8 3 0 0 3 3 3 0 Connexin DUF2828 PF11443.8 CDI83754.1 - 5.5 4.9 18.9 1.8 6.5 14.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) DUF2370 PF10176.9 CDI83754.1 - 7.1 6.2 13.3 0.36 10.4 5.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Rad21_Rec8 PF04824.16 CDI83760.1 - 0.0012 18.1 0.3 0.0032 16.7 0.3 1.8 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SPRY PF00622.28 CDI83761.1 - 0.0072 16.4 0.3 0.24 11.5 0.0 3.4 3 0 0 3 3 3 1 SPRY domain DUF4199 PF13858.6 CDI83761.1 - 4.1 7.8 0.0 4.1 7.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) zf-RING_2 PF13639.6 CDI83762.1 - 4e-08 33.5 12.4 5e-08 33.2 4.6 2.6 3 0 0 3 3 2 1 Ring finger domain zf-RING_5 PF14634.6 CDI83762.1 - 1.7e-07 31.1 7.1 2.1e-07 30.8 1.4 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDI83762.1 - 2.1e-07 30.7 3.4 2.1e-07 30.7 3.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDI83762.1 - 1.8e-06 27.7 8.0 3.1e-06 26.9 3.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI83762.1 - 3.3e-06 26.8 7.7 1.2e-05 25.0 2.3 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI83762.1 - 7.6e-06 25.9 5.4 5.5e-05 23.1 1.3 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 CDI83762.1 - 7.9e-06 26.1 1.9 7.9e-06 26.1 1.9 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CDI83762.1 - 3.4e-05 23.6 6.3 0.0002 21.1 1.8 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDI83762.1 - 0.0059 16.7 2.3 0.0059 16.7 2.3 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CDI83762.1 - 0.077 13.0 0.2 0.2 11.7 0.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CDI83762.1 - 0.15 11.9 5.8 0.13 12.1 1.4 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 CDI83762.1 - 0.31 10.9 5.1 0.13 12.1 2.1 1.9 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 CDI83762.1 - 1.6 9.0 6.5 0.49 10.6 2.1 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 CDI83762.1 - 2.1 8.2 6.7 4.9 7.0 1.1 3.0 3 0 0 3 3 3 0 RING-like zinc finger Cellsynth_D PF03500.13 CDI83766.1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Cellulose synthase subunit D Syja_N PF02383.18 CDI83767.1 - 2.2e-35 122.5 0.0 2.9e-18 66.3 0.0 3.9 3 2 0 3 3 3 2 SacI homology domain SPX PF03105.19 CDI83767.1 - 0.19 11.6 0.0 0.19 11.6 0.0 4.2 2 1 1 3 3 3 0 SPX domain Spt20 PF12090.8 CDI83768.1 - 2.9 7.5 31.0 1.3 8.5 0.3 3.3 3 0 0 3 3 3 0 Spt20 family PigN PF04987.14 CDI83768.1 - 4.7 5.9 7.4 8 5.2 7.4 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) FHA PF00498.26 CDI83770.1 - 1e-13 51.4 0.1 1.3e-10 41.4 0.0 2.9 2 0 0 2 2 2 2 FHA domain RINGv PF12906.7 CDI83770.1 - 3.8e-12 46.1 5.7 9.5e-12 44.9 5.7 1.7 1 0 0 1 1 1 1 RING-variant domain Yop-YscD_cpl PF16697.5 CDI83770.1 - 0.0055 17.0 0.0 0.0055 17.0 0.0 4.2 4 0 0 4 4 4 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_2 PF13639.6 CDI83770.1 - 0.17 12.3 6.1 0.32 11.4 6.1 1.5 1 0 0 1 1 1 0 Ring finger domain CH_2 PF06294.11 CDI83771.1 - 8.7e-12 45.0 0.0 3.5e-07 30.2 0.0 2.6 2 1 1 3 3 3 2 CH-like domain in sperm protein CAMSAP_CH PF11971.8 CDI83771.1 - 0.00042 20.1 0.0 0.00076 19.3 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain Peptidase_M60 PF13402.6 CDI83771.1 - 0.23 10.9 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase M60, enhancin and enhancin-like DUF3972 PF13118.6 CDI83771.1 - 0.25 11.8 2.9 0.32 11.4 1.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) SlyX PF04102.12 CDI83771.1 - 0.31 11.7 3.1 1.1 9.9 1.4 2.1 2 0 0 2 2 2 0 SlyX Adaptin_N PF01602.20 CDI83773.1 - 2.5e-31 108.8 0.4 6.7e-22 77.7 0.2 3.2 2 1 0 2 2 2 2 Adaptin N terminal region Coatomer_g_Cpla PF16381.5 CDI83773.1 - 1.9e-17 63.4 0.1 9e-17 61.3 0.1 2.2 1 1 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform COP-gamma_platf PF08752.10 CDI83773.1 - 6.1e-08 32.9 0.0 2.1e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain COX14 PF14880.6 CDI83774.1 - 1.4e-05 24.8 0.1 1.4e-05 24.8 0.1 3.3 3 1 0 3 3 3 1 Cytochrome oxidase c assembly FHIPEP PF00771.20 CDI83774.1 - 0.016 13.7 0.7 0.019 13.4 0.7 1.0 1 0 0 1 1 1 0 FHIPEP family Exonuc_VII_L PF02601.15 CDI83774.1 - 0.15 11.6 10.5 0.15 11.6 10.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SR-25 PF10500.9 CDI83775.1 - 1.8e-05 24.5 16.1 1.8e-05 24.5 16.1 5.9 4 1 0 4 4 4 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI83775.1 - 0.0028 18.0 11.6 0.0028 18.0 11.6 6.5 2 2 1 3 3 3 1 Anti-sigma-K factor rskA DUF4667 PF15700.5 CDI83775.1 - 0.0061 16.7 9.4 0.0061 16.7 9.4 3.7 3 1 0 3 3 3 2 Domain of unknown function (DUF4667) DUF5131 PF07505.11 CDI83775.1 - 0.13 11.7 3.7 0.1 12.1 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF5131) MIF4G PF02854.19 CDI83778.1 - 0.0007 19.3 1.5 0.0015 18.2 0.9 1.8 2 0 0 2 2 2 1 MIF4G domain SR-25 PF10500.9 CDI83785.1 - 0.0028 17.3 3.9 0.0028 17.3 3.9 3.2 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein LMBR1 PF04791.16 CDI83785.1 - 0.0073 15.3 1.8 0.0073 15.3 1.8 3.8 1 1 3 4 4 4 2 LMBR1-like membrane protein TFIIA PF03153.13 CDI83785.1 - 0.0082 16.2 42.6 0.12 12.4 13.7 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Dehydrin PF00257.19 CDI83785.1 - 0.027 15.0 3.6 0.027 15.0 3.6 3.5 3 0 0 3 3 3 0 Dehydrin ETRAMP PF09716.10 CDI83785.1 - 0.15 12.1 0.0 0.62 10.2 0.0 2.1 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TMEM132D_C PF15706.5 CDI83785.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.9 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Neur_chan_memb PF02932.16 CDI83785.1 - 1.4 8.9 10.5 1.8 8.6 1.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Hexokinase_1 PF00349.21 CDI83787.1 - 1.1e-19 71.1 0.0 1.2e-19 71.0 0.0 1.0 1 0 0 1 1 1 1 Hexokinase Presenilin PF01080.17 CDI83788.1 - 0.0011 17.8 17.8 0.0011 17.8 17.8 1.6 2 0 0 2 2 2 1 Presenilin Neur_chan_memb PF02932.16 CDI83788.1 - 0.0021 18.1 13.3 0.0021 18.1 13.3 1.9 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Selenoprotein_S PF06936.11 CDI83788.1 - 0.016 15.0 21.9 0.036 13.9 21.9 1.6 1 0 0 1 1 1 0 Selenoprotein S (SelS) DcuA_DcuB PF03605.14 CDI83788.1 - 0.045 12.6 0.2 0.045 12.6 0.2 3.1 2 1 1 3 3 2 0 Anaerobic c4-dicarboxylate membrane transporter GAGA_bind PF06217.12 CDI83788.1 - 0.061 13.6 18.7 0.1 12.9 18.7 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.14 CDI83788.1 - 0.074 11.3 20.0 0.11 10.8 20.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Membralin PF09746.9 CDI83788.1 - 0.12 11.3 9.9 0.19 10.7 9.9 1.3 1 0 0 1 1 1 0 Tumour-associated protein SID-1_RNA_chan PF13965.6 CDI83788.1 - 0.15 10.4 5.2 0.23 9.8 5.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Macoilin PF09726.9 CDI83788.1 - 0.15 10.5 24.7 0.26 9.8 24.7 1.3 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 CDI83788.1 - 0.21 10.6 24.3 0.33 9.9 24.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 CDI83788.1 - 0.26 10.2 16.1 8.8 5.2 16.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PPL5 PF18168.1 CDI83788.1 - 0.5 9.6 14.5 1 8.6 14.5 1.6 1 0 0 1 1 1 0 Prim-pol family 5 eIF-3_zeta PF05091.12 CDI83788.1 - 0.77 8.7 27.8 1.1 8.2 27.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Nha1_C PF08619.10 CDI83788.1 - 0.78 8.9 34.1 0.74 9.0 27.2 2.1 1 1 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus Exonuc_VII_L PF02601.15 CDI83788.1 - 0.87 9.1 33.5 0.055 13.0 28.3 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit ALMT PF11744.8 CDI83788.1 - 1 8.1 19.9 1.5 7.5 19.5 1.5 2 0 0 2 2 2 0 Aluminium activated malate transporter TT_ORF1 PF02956.14 CDI83788.1 - 1.6 7.3 14.0 2.6 6.6 14.0 1.3 1 0 0 1 1 1 0 TT viral orf 1 DUF4746 PF15928.5 CDI83788.1 - 2.5 7.5 19.8 4.1 6.7 19.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CSG2 PF16965.5 CDI83788.1 - 2.6 6.9 12.6 4.4 6.2 12.6 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator Suf PF05843.14 CDI83788.1 - 3.9 7.4 27.8 2.1 8.3 23.9 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) LMBR1 PF04791.16 CDI83788.1 - 4.1 6.2 12.1 4.9 6.0 12.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein GPCR_chapero_1 PF11904.8 CDI83788.1 - 5.1 6.4 14.5 9.4 5.6 14.5 1.5 1 0 0 1 1 1 0 GPCR-chaperone DUF2052 PF09747.9 CDI83788.1 - 5.6 7.0 35.9 12 5.9 35.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 CDI83788.1 - 7.2 6.3 31.8 15 5.3 31.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4045 PF13254.6 CDI83788.1 - 7.5 6.1 26.5 0.2 11.3 17.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) DUF2009 PF09418.10 CDI83789.1 - 4.1e-107 359.1 9.6 4e-35 121.8 0.2 4.7 3 2 2 5 5 5 4 Protein of unknown function (DUF2009) HupE_UreJ_2 PF13795.6 CDI83789.1 - 0.11 12.2 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 HupE / UreJ protein TerB_C PF15615.6 CDI83789.1 - 0.51 10.6 7.9 5.2 7.3 0.2 2.4 2 0 0 2 2 2 0 TerB-C domain OmpH PF03938.14 CDI83790.1 - 0.32 11.3 18.0 0.65 10.3 18.0 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TFIIA PF03153.13 CDI83790.1 - 0.49 10.3 28.1 0.85 9.5 28.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4441 PF14536.6 CDI83790.1 - 0.6 10.3 7.3 1 9.6 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4441) Insulin PF00049.18 CDI83790.1 - 5.1 8.2 7.0 32 5.6 0.3 2.7 2 1 0 2 2 2 0 Insulin/IGF/Relaxin family AT_hook PF02178.19 CDI83793.1 - 0.26 11.3 4.5 0.6 10.2 4.5 1.7 1 0 0 1 1 1 0 AT hook motif UQ_con PF00179.26 CDI83794.1 - 3.1e-54 182.4 0.0 3.5e-54 182.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDI83794.1 - 0.00019 21.2 0.0 0.00022 20.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CDI83794.1 - 0.01 16.1 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 CDI83794.1 - 0.049 13.5 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 UEV domain RR_TM4-6 PF06459.12 CDI83795.1 - 0.03 14.1 10.7 0.049 13.5 10.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 CDI83795.1 - 0.033 12.3 7.2 0.049 11.7 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CCSAP PF15748.5 CDI83795.1 - 0.066 13.4 11.8 0.1 12.7 11.8 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PA26 PF04636.13 CDI83795.1 - 0.087 11.7 9.4 0.15 10.9 9.4 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF913 PF06025.12 CDI83795.1 - 0.1 11.6 7.4 0.26 10.2 7.4 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4366 PF14283.6 CDI83795.1 - 0.14 12.2 5.9 0.33 11.0 5.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) LAP1C PF05609.12 CDI83795.1 - 0.17 10.9 16.5 0.33 10.0 16.5 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2126 PF09899.9 CDI83795.1 - 0.28 9.2 4.8 0.38 8.8 4.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Lin-8 PF03353.15 CDI83795.1 - 0.63 9.6 16.2 0.11 12.0 12.4 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Hid1 PF12722.7 CDI83795.1 - 0.7 7.9 11.6 0.95 7.5 11.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI83795.1 - 0.79 8.4 16.3 1.2 7.8 16.3 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 CDI83795.1 - 1 8.5 7.8 1.6 7.9 7.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Bul1_C PF04426.12 CDI83795.1 - 1.1 8.6 18.4 0.062 12.7 13.1 1.5 2 0 0 2 2 2 0 Bul1 C terminus Gti1_Pac2 PF09729.9 CDI83795.1 - 1.2 9.1 10.5 2.3 8.3 10.5 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4050 PF13259.6 CDI83795.1 - 1.4 9.2 12.1 3.4 8.0 12.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) ORC_WH_C PF18137.1 CDI83795.1 - 2 8.5 11.8 5.3 7.1 11.8 1.7 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal TCP PF03634.13 CDI83795.1 - 2.2 8.8 15.5 6.3 7.4 15.5 1.8 1 0 0 1 1 1 0 TCP family transcription factor AUX_IAA PF02309.16 CDI83795.1 - 2.2 8.0 8.8 4.3 7.1 8.8 1.5 1 0 0 1 1 1 0 AUX/IAA family PAT1 PF09770.9 CDI83795.1 - 2.5 6.3 29.5 0.0096 14.3 20.1 1.6 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Sin_N PF04801.13 CDI83795.1 - 2.6 7.2 25.3 0.017 14.4 16.6 1.7 2 0 0 2 2 2 0 Sin-like protein conserved region PIP5K PF01504.18 CDI83795.1 - 2.6 7.2 8.9 4.2 6.5 8.9 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase FAM60A PF15396.6 CDI83795.1 - 2.7 7.9 11.7 5.1 7.0 11.7 1.4 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI83795.1 - 3.5 6.5 15.2 6 5.7 15.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF572 PF04502.13 CDI83795.1 - 4.5 6.8 17.3 0.59 9.7 9.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) Paramyxo_ncap PF00973.19 CDI83795.1 - 6.2 5.6 8.4 8.7 5.1 8.4 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein GREB1 PF15782.5 CDI83795.1 - 6.3 3.8 18.2 8.3 3.4 18.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2347 PF09804.9 CDI83795.1 - 6.9 6.2 10.4 2.4 7.7 6.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) SLC12 PF03522.15 CDI83795.1 - 7 5.6 16.7 12 4.8 16.7 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 CDI83795.1 - 7.9 5.4 8.6 14 4.6 8.6 1.3 1 0 0 1 1 1 0 Tumour-associated protein Rhodanese PF00581.20 CDI83796.1 - 1.8e-05 25.2 0.7 9.9e-05 22.8 0.1 2.5 2 0 0 2 2 2 1 Rhodanese-like domain Spt20 PF12090.8 CDI83796.1 - 0.0071 16.0 1.6 0.0071 16.0 1.6 7.2 4 2 3 7 7 7 2 Spt20 family AAA PF00004.29 CDI83796.1 - 2.3 8.6 4.5 43 4.5 0.0 3.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DnaJ PF00226.31 CDI83797.1 - 3.5e-10 39.8 0.1 7.1e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain SPX PF03105.19 CDI83800.1 - 0.00053 20.0 1.6 0.00053 20.0 1.6 4.3 4 0 0 4 4 4 4 SPX domain DUF3071 PF11268.8 CDI83801.1 - 0.053 13.6 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) ATP-synt_10 PF05176.14 CDI83802.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 ATP10 protein IMS PF00817.20 CDI83803.1 - 8.9e-11 42.0 1.9 1.3e-05 25.3 0.5 2.7 1 1 0 2 2 2 2 impB/mucB/samB family BRCT_2 PF16589.5 CDI83803.1 - 7.7e-05 23.0 0.0 0.004 17.5 0.0 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RskA PF10099.9 CDI83803.1 - 0.0022 18.3 11.6 0.0022 18.3 11.6 12.1 4 4 3 7 7 7 1 Anti-sigma-K factor rskA Velvet PF11754.8 CDI83803.1 - 0.097 12.6 0.1 0.097 12.6 0.1 5.4 4 2 0 4 4 4 0 Velvet factor DEAD PF00270.29 CDI83804.1 - 1.8e-40 138.6 0.0 1.8e-40 138.6 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase DUF4217 PF13959.6 CDI83804.1 - 2.6e-14 53.2 0.6 7.7e-14 51.7 0.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 CDI83804.1 - 1.8e-11 44.4 0.1 1.8e-11 44.4 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDI83804.1 - 1.7e-06 28.2 0.5 1.1e-05 25.6 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MMR1 PF08505.10 CDI83804.1 - 3.2 8.0 41.6 0.55 10.5 15.6 3.4 3 0 0 3 3 3 0 Mitochondrial Myo2 receptor-related protein DER1 PF04511.15 CDI83805.1 - 4.7e-32 111.5 8.6 5.4e-32 111.3 8.6 1.0 1 0 0 1 1 1 1 Der1-like family Maf1 PF09174.10 CDI83806.1 - 1.7e-26 93.4 1.1 1.8e-25 90.1 1.1 2.0 1 1 0 1 1 1 1 Maf1 regulator HSP90 PF00183.18 CDI83807.1 - 5e-192 639.4 22.9 6.3e-192 639.1 22.9 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CDI83807.1 - 1e-10 42.1 0.0 2e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDI83807.1 - 7.8e-10 38.7 2.9 1.2e-09 38.1 0.1 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2722 PF10846.8 CDI83807.1 - 8.3 5.2 9.8 17 4.2 4.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) zf-RING_2 PF13639.6 CDI83808.1 - 1.1e-11 44.9 10.5 1.5e-11 44.5 10.5 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDI83808.1 - 1.7e-08 34.6 6.8 3.1e-08 33.8 6.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDI83808.1 - 1.2e-06 28.2 8.4 1.7e-06 27.8 8.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CDI83808.1 - 1.6e-06 28.1 2.9 2.7e-06 27.3 2.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CDI83808.1 - 2.8e-06 27.0 2.5 2.8e-06 27.0 2.5 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDI83808.1 - 5.9e-06 26.0 10.0 9.3e-06 25.4 10.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 CDI83808.1 - 7.1e-06 26.1 5.4 1.2e-05 25.3 5.4 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_5 PF14634.6 CDI83808.1 - 9.4e-06 25.5 6.6 1.5e-05 24.8 6.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDI83808.1 - 5.7e-05 23.0 2.8 6.4e-05 22.9 0.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDI83808.1 - 0.00012 21.8 6.1 0.0002 21.1 6.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CDI83808.1 - 0.00021 21.0 4.6 0.00032 20.4 4.6 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain DUF5318 PF17249.2 CDI83808.1 - 0.00091 19.0 2.3 0.0017 18.1 2.3 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5318) Prok-RING_4 PF14447.6 CDI83808.1 - 0.002 17.9 9.5 0.0032 17.3 7.0 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 CDI83808.1 - 0.0092 16.1 6.3 0.062 13.5 6.4 2.0 1 1 1 2 2 2 1 FANCL C-terminal domain zf-P11 PF03854.14 CDI83808.1 - 0.0098 15.5 1.0 0.0098 15.5 1.0 2.1 1 1 1 2 2 2 1 P-11 zinc finger RskA PF10099.9 CDI83808.1 - 0.012 15.9 1.0 0.018 15.4 1.0 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Zn_ribbon_17 PF17120.5 CDI83808.1 - 0.022 14.4 6.3 0.034 13.8 6.3 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 CDI83808.1 - 0.042 13.8 6.8 0.32 10.9 3.4 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Rad50_zn_hook PF04423.14 CDI83808.1 - 0.26 11.2 2.4 1.4 8.8 0.0 2.5 3 0 0 3 3 3 0 Rad50 zinc hook motif CTU2 PF10288.9 CDI83808.1 - 3.4 8.0 5.3 1.3e+02 2.8 5.3 2.2 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C3HC4_2 PF13923.6 CDI83809.1 - 9.3e-10 38.2 8.0 2.4e-09 36.9 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI83809.1 - 6.3e-08 32.4 6.7 1.5e-07 31.2 6.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI83809.1 - 7.9e-07 29.3 7.2 1.9e-06 28.1 7.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDI83809.1 - 1.8e-06 27.7 7.6 4.3e-06 26.5 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDI83809.1 - 2.1e-06 27.5 5.1 5.7e-06 26.2 5.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDI83809.1 - 3.8e-06 26.8 9.4 1.3e-05 25.2 9.4 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDI83809.1 - 0.00015 21.6 8.8 0.00035 20.4 8.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDI83809.1 - 0.00043 20.4 11.2 0.0014 18.7 11.2 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING TFIIA PF03153.13 CDI83809.1 - 0.00096 19.3 11.9 0.00096 19.3 11.9 6.5 4 2 0 5 5 3 1 Transcription factor IIA, alpha/beta subunit zf-RING_6 PF14835.6 CDI83809.1 - 0.031 14.1 6.2 0.078 12.9 6.2 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Peptidase_C97 PF05903.14 CDI83809.1 - 0.15 11.9 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 PPPDE putative peptidase domain zf-rbx1 PF12678.7 CDI83809.1 - 4.5 7.6 11.2 0.097 13.0 3.3 2.5 2 0 0 2 2 1 0 RING-H2 zinc finger domain zinc_ribbon_15 PF17032.5 CDI83809.1 - 7.5 7.4 7.2 73 4.2 0.1 3.2 2 0 0 2 2 2 0 zinc-ribbon family Ribosomal_L5e PF17144.4 CDI83811.1 - 4.4e-81 270.7 0.9 4.4e-81 270.7 0.9 1.7 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CDI83811.1 - 2.9e-31 108.3 7.7 2.9e-31 108.3 7.7 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF885 PF05960.11 CDI83811.1 - 0.058 13.0 2.7 0.08 12.6 2.7 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) VitK2_biosynth PF02621.14 CDI83811.1 - 0.16 11.4 1.4 0.29 10.6 1.4 1.5 1 0 0 1 1 1 0 Menaquinone biosynthesis RCC1 PF00415.18 CDI83812.1 - 2.4e-68 226.6 33.3 3.2e-14 53.3 1.1 8.1 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI83812.1 - 2.9e-39 132.1 54.9 6.3e-09 35.4 1.4 8.4 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 CDI83812.1 - 1.8e-05 24.6 0.4 1.3 8.7 0.0 5.0 5 0 0 5 5 5 1 TUP1-like enhancer of split Kelch_2 PF07646.15 CDI83812.1 - 6.9e-05 22.7 6.7 16 5.7 0.0 5.8 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 CDI83812.1 - 0.087 13.1 5.7 45 4.5 0.2 5.1 6 0 0 6 6 6 0 Kelch motif Thioredoxin PF00085.20 CDI83813.1 - 5e-37 126.0 0.0 2.8e-20 72.2 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 CDI83813.1 - 9.8e-11 41.9 0.0 4.5e-07 30.0 0.0 3.4 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDI83813.1 - 0.0024 18.3 0.0 0.12 12.9 0.0 2.9 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDI83813.1 - 0.013 15.8 0.0 13 6.2 0.0 3.2 3 0 0 3 3 3 0 Thioredoxin-like AhpC-TSA PF00578.21 CDI83813.1 - 0.059 13.3 0.0 1.7 8.6 0.0 2.6 3 0 0 3 3 3 0 AhpC/TSA family DUF2722 PF10846.8 CDI83814.1 - 1.8e-05 23.9 59.4 0.00083 18.4 15.3 4.4 4 0 0 4 4 4 3 Protein of unknown function (DUF2722) DUF2076 PF09849.9 CDI83814.1 - 0.0034 17.5 14.5 0.0034 17.5 14.5 6.8 4 2 1 5 5 5 2 Uncharacterized protein conserved in bacteria (DUF2076) DUF3371 PF11851.8 CDI83814.1 - 8.3 7.5 44.0 4 8.5 4.9 5.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3371) DnaJ PF00226.31 CDI83816.1 - 9.9e-13 48.0 0.0 2.4e-11 43.6 0.0 2.4 1 1 0 1 1 1 1 DnaJ domain AP2 PF00847.20 CDI83817.1 - 3.8e-07 30.2 0.5 2.5e-06 27.6 0.5 2.5 1 1 0 1 1 1 1 AP2 domain CAP PF00188.26 CDI83819.1 - 0.00027 21.8 0.1 0.00027 21.8 0.1 3.3 2 2 0 2 2 2 1 Cysteine-rich secretory protein family Utp14 PF04615.13 CDI83819.1 - 0.67 8.5 39.1 0.9 8.0 39.1 1.2 1 0 0 1 1 1 0 Utp14 protein Draxin PF15550.6 CDI83819.1 - 9.8 5.9 20.4 17 5.2 20.4 1.5 1 0 0 1 1 1 0 Draxin SDA1 PF05285.12 CDI83821.1 - 0.021 14.3 8.3 0.029 13.8 8.3 1.2 1 0 0 1 1 1 0 SDA1 PKD_channel PF08016.12 CDI83822.1 - 0.00047 18.9 32.5 0.0098 14.6 7.0 3.5 4 0 0 4 4 4 2 Polycystin cation channel Molybdopterin_N PF18364.1 CDI83822.1 - 0.038 14.0 0.1 0.087 12.9 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin oxidoreductase N-terminal domain DUF948 PF06103.11 CDI83822.1 - 1.7 9.0 5.0 50 4.3 1.3 3.8 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Baculo_11_kDa PF06143.11 CDI83822.1 - 5.6 6.6 9.1 22 4.7 0.5 3.8 3 0 0 3 3 3 0 Baculovirus 11 kDa family MAJIN PF15077.6 CDI83823.1 - 0.45 10.3 2.8 0.67 9.7 2.8 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein TRAP_alpha PF03896.16 CDI83823.1 - 1.7 7.8 3.1 2.9 7.0 3.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TPR_12 PF13424.6 CDI83825.1 - 2.4e-08 34.1 0.0 0.0015 18.8 0.0 3.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDI83825.1 - 7.4e-05 22.5 8.0 0.0085 15.9 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDI83825.1 - 0.011 15.6 0.1 3.6 7.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4248 PF14053.6 CDI83825.1 - 5.1 7.2 9.5 18 5.4 5.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) DUF1764 PF08576.10 CDI83826.1 - 6.2e-12 46.3 7.7 6.2e-12 46.3 7.7 4.2 1 1 3 4 4 4 1 Eukaryotic protein of unknown function (DUF1764) RskA PF10099.9 CDI83826.1 - 3e-05 24.4 51.7 0.047 14.0 15.0 4.1 1 1 2 3 3 3 3 Anti-sigma-K factor rskA SR-25 PF10500.9 CDI83826.1 - 0.96 9.0 62.1 1.7 8.2 33.7 3.3 1 1 2 3 3 3 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 CDI83827.1 - 0.014 15.4 6.9 0.086 12.7 1.7 2.1 2 0 0 2 2 2 0 SPX domain Apt1 PF10351.9 CDI83827.1 - 5.9 5.6 11.3 1.6 7.5 1.4 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Sec3_C PF09763.9 CDI83827.1 - 7.8 4.7 5.2 17 3.6 0.1 2.0 2 0 0 2 2 2 0 Exocyst complex component Sec3 IspD PF01128.19 CDI83828.1 - 2.5e-15 56.8 14.4 2.1e-11 44.0 7.0 4.5 4 1 0 4 4 4 2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase RskA PF10099.9 CDI83828.1 - 0.0035 17.7 4.6 0.0035 17.7 4.6 6.5 2 1 1 3 3 3 2 Anti-sigma-K factor rskA GxGYxYP_N PF16216.5 CDI83828.1 - 0.056 13.6 2.9 0.13 12.4 2.9 1.5 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal Nucleoside_tran PF01733.18 CDI83828.1 - 6.1 6.1 9.4 6.7 6.0 0.2 3.1 3 0 0 3 3 3 0 Nucleoside transporter ACDC PF14733.6 CDI83830.1 - 1.4e-14 54.2 0.0 1.4e-14 54.2 0.0 2.4 2 0 0 2 2 2 1 AP2-coincident C-terminal AP2 PF00847.20 CDI83830.1 - 2.1e-11 43.8 1.7 1.3e-06 28.5 0.0 3.3 3 0 0 3 3 3 2 AP2 domain Androgen_recep PF02166.16 CDI83831.1 - 0.035 13.0 0.2 0.035 13.0 0.2 3.4 3 1 1 4 4 4 0 Androgen receptor Spt20 PF12090.8 CDI83832.1 - 0.064 12.9 6.6 0.1 12.2 6.6 1.3 1 0 0 1 1 1 0 Spt20 family Ripply PF14998.6 CDI83832.1 - 0.13 12.9 2.7 0.35 11.5 2.7 1.7 1 0 0 1 1 1 0 Transcription Regulator SUIM_assoc PF16619.5 CDI83832.1 - 0.16 12.1 9.1 0.37 10.9 9.1 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Secretin_N_2 PF07655.13 CDI83833.1 - 0.00085 19.8 10.6 0.0028 18.2 10.6 1.9 1 0 0 1 1 1 1 Secretin N-terminal domain BBS2_C PF14782.6 CDI83833.1 - 0.66 8.7 9.0 2.7 6.7 1.6 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal RAP1 PF07218.11 CDI83833.1 - 2.1 6.5 9.8 3.2 5.9 9.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2722 PF10846.8 CDI83836.1 - 2.4e-06 26.8 1.4 2.4e-06 26.8 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI83836.1 - 0.024 14.7 10.7 0.027 14.5 10.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 CDI83836.1 - 0.032 12.9 12.0 0.036 12.8 12.0 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Dpy19 PF10034.9 CDI83836.1 - 0.076 11.2 0.1 0.083 11.1 0.1 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation WBP-1 PF11669.8 CDI83836.1 - 0.12 13.1 6.0 6.1 7.5 0.0 2.2 2 0 0 2 2 2 0 WW domain-binding protein 1 Suf PF05843.14 CDI83836.1 - 0.16 12.0 4.4 0.18 11.7 4.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Spt20 PF12090.8 CDI83836.1 - 0.61 9.7 22.3 0.84 9.2 22.3 1.1 1 0 0 1 1 1 0 Spt20 family FHIPEP PF00771.20 CDI83836.1 - 0.66 8.4 4.4 0.74 8.2 0.3 2.0 2 0 0 2 2 2 0 FHIPEP family DUF2973 PF11189.8 CDI83836.1 - 1.7 8.8 6.8 12 6.1 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) Activator_LAG-3 PF11498.8 CDI83836.1 - 2.3 7.1 25.2 3.3 6.6 25.2 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FTZ PF03867.14 CDI83836.1 - 3.5 7.1 8.5 4.7 6.7 8.5 1.1 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region EphA2_TM PF14575.6 CDI83836.1 - 4.4 8.2 8.1 15 6.6 4.2 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain UPF0560 PF10577.9 CDI83836.1 - 4.8 5.6 9.5 6.1 5.2 9.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4834 PF16118.5 CDI83836.1 - 5.5 8.0 12.7 16 6.6 8.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ribosomal_L18A PF01775.17 CDI83837.1 - 1.4e-49 167.2 0.1 1.7e-49 166.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A HtrL_YibB PF09612.10 CDI83838.1 - 1.8e-05 24.4 0.0 0.00049 19.7 0.0 2.5 3 0 0 3 3 3 1 Bacterial protein of unknown function (HtrL_YibB) TFIIA PF03153.13 CDI83838.1 - 0.0016 18.5 32.4 0.0016 18.5 32.4 3.6 4 1 0 4 4 3 2 Transcription factor IIA, alpha/beta subunit MecA PF05389.12 CDI83838.1 - 0.0051 16.5 16.8 0.24 11.0 1.0 3.5 3 0 0 3 3 3 2 Negative regulator of genetic competence (MecA) FmiP_Thoc5 PF09766.9 CDI83838.1 - 0.0075 15.6 27.9 0.02 14.2 2.6 3.3 3 0 0 3 3 3 3 Fms-interacting protein/Thoc5 UPF0565 PF10561.9 CDI83838.1 - 0.13 11.4 0.0 0.13 11.4 0.0 3.5 3 1 0 3 3 2 0 Uncharacterised protein family UPF0565 Connexin PF00029.19 CDI83838.1 - 0.33 10.7 21.8 0.65 9.7 0.9 3.3 3 0 0 3 3 3 0 Connexin EOS1 PF12326.8 CDI83838.1 - 0.55 10.1 13.4 2.4 8.0 0.0 3.7 3 1 0 3 3 3 0 N-glycosylation protein Pet20 PF08692.10 CDI83838.1 - 0.77 10.5 17.5 3.4 8.4 0.5 3.5 3 0 0 3 3 3 0 Mitochondrial protein Pet20 TCP PF03634.13 CDI83838.1 - 1.1 9.8 32.3 2.3 8.8 1.7 4.5 4 0 0 4 4 4 0 TCP family transcription factor SpoIIP PF07454.11 CDI83838.1 - 1.6 8.1 34.1 2.6 7.4 7.3 3.4 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 CDI83838.1 - 1.8 6.7 53.3 1.1 7.4 23.1 3.1 3 0 0 3 3 3 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 CDI83838.1 - 2.3 6.5 6.2 7.1 4.9 0.6 2.9 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 CDC45 PF02724.14 CDI83838.1 - 2.8 6.1 20.3 1.2 7.4 2.4 3.3 3 0 0 3 3 3 0 CDC45-like protein Neur_chan_memb PF02932.16 CDI83838.1 - 3.7 7.6 25.4 2 8.4 7.5 3.6 4 0 0 4 4 4 0 Neurotransmitter-gated ion-channel transmembrane region BORG_CEP PF14957.6 CDI83838.1 - 4.1 8.6 31.9 2.1 9.5 1.4 4.4 4 0 0 4 4 4 0 Cdc42 effector DUF1980 PF09323.10 CDI83838.1 - 4.3 7.2 23.6 0.3 11.0 1.5 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF1980) EIIBC-GUT_N PF03612.14 CDI83838.1 - 6.3 6.5 27.9 2.8 7.7 4.7 3.7 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus FAM60A PF15396.6 CDI83838.1 - 6.5 6.7 26.3 1.7 8.6 2.5 4.1 4 0 0 4 4 4 0 Protein Family FAM60A DUF2722 PF10846.8 CDI83839.1 - 0.00041 19.4 4.1 0.00041 19.4 4.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI83839.1 - 0.0037 17.9 2.2 0.004 17.8 2.2 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 CDI83839.1 - 0.006 16.2 5.9 0.0067 16.1 5.9 1.2 1 0 0 1 1 1 1 Spt20 family Secretin_N_2 PF07655.13 CDI83839.1 - 0.0098 16.4 9.3 0.014 15.9 9.3 1.2 1 0 0 1 1 1 1 Secretin N-terminal domain KCNQ2_u3 PF16642.5 CDI83839.1 - 0.026 15.5 4.8 0.034 15.1 4.8 1.3 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 CDK2AP PF09806.9 CDI83839.1 - 0.074 13.1 4.4 0.1 12.6 4.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Suf PF05843.14 CDI83839.1 - 0.18 11.7 2.3 0.2 11.6 2.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Uds1 PF15456.6 CDI83839.1 - 1.4 9.0 5.6 1.9 8.6 5.6 1.2 1 0 0 1 1 1 0 Up-regulated During Septation MRI PF15325.6 CDI83839.1 - 4.5 8.4 6.1 6.7 7.8 6.1 1.2 1 0 0 1 1 1 0 Modulator of retrovirus infection Orf78 PF06024.12 CDI83839.1 - 4.6 7.6 5.3 7 7.0 5.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Presenilin PF01080.17 CDI83839.1 - 7.6 5.2 7.7 9.3 4.9 7.7 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CDI83840.1 - 9 4.7 10.7 11 4.4 10.7 1.1 1 0 0 1 1 1 0 Macoilin family Bud13 PF09736.9 CDI83841.1 - 8.5e-12 45.7 12.2 1.3e-11 45.1 7.9 3.0 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex AAA PF00004.29 CDI83842.1 - 3.2e-38 131.1 0.0 6.3e-38 130.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI83842.1 - 2.6e-08 33.5 0.1 5.8e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDI83842.1 - 9.7e-07 29.3 4.8 0.00034 21.1 0.2 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CDI83842.1 - 0.00027 21.2 0.1 0.032 14.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDI83842.1 - 0.00048 20.1 0.0 0.0017 18.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDI83842.1 - 0.0029 17.7 0.2 0.011 15.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 CDI83842.1 - 0.0054 16.2 0.1 0.01 15.3 0.1 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_30 PF13604.6 CDI83842.1 - 0.016 14.9 0.0 0.038 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDI83842.1 - 0.029 13.9 0.0 0.068 12.7 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 CDI83842.1 - 0.04 13.3 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CDI83842.1 - 0.042 13.6 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CDI83842.1 - 0.045 13.0 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activat PF00158.26 CDI83842.1 - 0.071 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain RuvB_N PF05496.12 CDI83842.1 - 0.076 12.8 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDI83842.1 - 0.12 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 CDI83842.1 - 0.13 12.2 0.2 0.4 10.6 0.1 1.8 1 1 0 1 1 1 0 NACHT domain TsaE PF02367.17 CDI83842.1 - 0.17 11.9 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RRM_1 PF00076.22 CDI83845.1 - 6.8e-36 121.9 0.1 1.1e-16 60.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI83845.1 - 5e-06 26.4 0.0 0.0067 16.4 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CDI83845.1 - 3.4e-05 23.6 0.0 0.0091 15.8 0.0 2.8 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 CDI83845.1 - 0.018 15.1 0.0 0.77 9.9 0.0 3.0 2 1 0 2 2 2 0 RNA recognition motif MtaB PF12176.8 CDI83846.1 - 0.011 14.5 1.8 0.013 14.4 1.8 1.0 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit DUF1043 PF06295.12 CDI83846.1 - 0.019 15.0 0.2 0.022 14.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) SHR3_chaperone PF08229.11 CDI83846.1 - 0.14 11.2 0.1 0.22 10.5 0.1 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 RPAP1_C PF08620.10 CDI83846.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.4 1 1 0 1 1 1 0 RPAP1-like, C-terminal DUF4349 PF14257.6 CDI83846.1 - 0.17 11.3 1.9 0.24 10.8 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) CK2S PF15011.6 CDI83847.1 - 0.019 14.9 0.1 0.041 13.8 0.1 1.5 1 0 0 1 1 1 0 Casein Kinase 2 substrate NPV_P10 PF05531.12 CDI83847.1 - 0.056 13.9 0.2 0.46 11.0 0.7 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 CDI83847.1 - 0.11 13.1 2.0 0.27 11.9 2.0 1.6 1 0 0 1 1 1 0 SlyX DUF2057 PF09829.9 CDI83847.1 - 1.1 9.4 5.1 4.4 7.4 1.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Ribosomal_60s PF00428.19 CDI83847.1 - 2.2 9.0 22.0 0.62 10.7 5.5 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3597 PF12200.8 CDI83847.1 - 9.9 6.7 9.2 5.1 7.6 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) CFAP91 PF14738.6 CDI83850.1 - 4.2e-25 88.6 0.0 5e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Cilia- and flagella-associated protein 91 GRASP55_65 PF04495.14 CDI83851.1 - 2e-35 122.1 0.0 2.6e-34 118.5 0.0 2.0 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain RskA PF10099.9 CDI83851.1 - 0.0016 18.8 21.8 0.017 15.5 21.8 2.2 1 1 0 1 1 1 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI83851.1 - 0.0095 16.0 19.8 0.05 13.7 0.2 2.5 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 PDZ_6 PF17820.1 CDI83851.1 - 0.018 14.8 0.1 0.071 13.0 0.0 2.1 2 0 0 2 2 2 0 PDZ domain TraB PF01963.17 CDI83851.1 - 1.3 8.8 7.4 4.1 7.2 1.4 2.1 2 0 0 2 2 2 0 TraB family SUIM_assoc PF16619.5 CDI83852.1 - 1.3 9.2 53.2 0.44 10.6 0.6 6.7 6 1 0 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 CDI83853.1 - 0.0009 18.1 20.9 0.0009 18.1 20.9 2.1 2 1 0 2 2 2 1 Presenilin V_ATPase_I PF01496.19 CDI83853.1 - 0.0075 14.2 15.6 0.013 13.5 15.6 1.4 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Caldesmon PF02029.15 CDI83853.1 - 0.018 13.8 23.2 0.024 13.4 23.2 1.2 1 0 0 1 1 1 0 Caldesmon RR_TM4-6 PF06459.12 CDI83853.1 - 0.22 11.3 28.2 0.044 13.6 21.0 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FAM76 PF16046.5 CDI83853.1 - 0.36 10.2 24.4 1 8.6 24.4 1.8 1 0 0 1 1 1 0 FAM76 protein ALMT PF11744.8 CDI83853.1 - 1.1 8.0 20.6 2.4 6.9 20.6 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 CDI83853.1 - 1.5 7.1 25.3 2.4 6.3 25.3 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 CDI83853.1 - 1.8 7.5 26.8 3.5 6.5 26.8 1.4 1 0 0 1 1 1 0 Solute carrier family 12 DUF2828 PF11443.8 CDI83853.1 - 2.9 5.9 20.9 4.7 5.2 20.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDK5_activator PF03261.15 CDI83853.1 - 3.4 7.1 18.9 0.56 9.7 15.2 1.5 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein O-antigen_lig PF13425.6 CDI83853.1 - 3.5 6.3 11.0 4.8 5.8 11.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Lin-8 PF03353.15 CDI83853.1 - 4.1 6.9 38.9 2.9 7.4 31.0 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Membralin PF09746.9 CDI83853.1 - 6.8 5.6 15.1 11 4.9 15.1 1.3 1 0 0 1 1 1 0 Tumour-associated protein IER PF05760.12 CDI83853.1 - 7.7 6.7 34.0 0.77 10.0 5.4 2.3 2 0 0 2 2 2 0 Immediate early response protein (IER) Kinesin PF00225.23 CDI83854.1 - 7.9e-22 77.6 0.0 5.9e-16 58.3 0.0 2.5 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 CDI83854.1 - 0.00022 21.2 0.0 0.0022 18.0 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding PT PF04886.12 CDI83854.1 - 0.0019 17.7 5.0 0.0019 17.7 5.0 5.3 5 0 0 5 5 5 1 PT repeat TFIIA PF03153.13 CDI83854.1 - 2.3 8.1 32.7 4.4 7.2 1.1 2.8 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit HSP20 PF00011.21 CDI83855.1 - 1.4e-18 66.9 0.0 2.2e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDI83855.1 - 4.2e-06 26.2 0.0 6.7e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CODH_A_N PF18537.1 CDI83855.1 - 0.067 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain Cofilin_ADF PF00241.20 CDI83856.1 - 2.3e-27 95.2 0.0 2.9e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2842 PF11003.8 CDI83857.1 - 0.26 11.6 5.3 0.21 11.9 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) Rtf2 PF04641.12 CDI83858.1 - 4.7e-47 160.6 2.0 1e-46 159.4 2.0 1.5 1 1 0 1 1 1 1 Rtf2 RING-finger GREB1 PF15782.5 CDI83858.1 - 1.1 6.3 7.5 1.4 6.0 7.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 CDI83858.1 - 3.2 6.2 7.0 4.7 5.7 7.0 1.2 1 0 0 1 1 1 0 Macoilin family Roughex PF06020.11 CDI83858.1 - 9.2 5.2 7.6 13 4.8 7.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Aconitase PF00330.20 CDI83859.1 - 6.1e-180 599.1 0.0 7.9e-180 598.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDI83859.1 - 1.8e-43 148.0 0.0 3.1e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain LisH PF08513.11 CDI83859.1 - 0.13 12.3 0.1 0.98 9.5 0.0 2.3 2 0 0 2 2 2 0 LisH Spore_YhaL PF14147.6 CDI83860.1 - 1.3 8.8 3.3 2.7 7.8 3.3 1.5 1 0 0 1 1 1 0 Sporulation protein YhaL adh_short_C2 PF13561.6 CDI83861.1 - 3.7e-28 98.7 1.4 5.1e-24 85.1 1.3 2.5 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDI83861.1 - 1.3e-26 93.3 1.4 5.5e-26 91.2 1.4 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDI83861.1 - 5.3e-07 29.7 0.1 5.3e-07 29.7 0.1 1.7 2 0 0 2 2 2 1 KR domain TFIIA PF03153.13 CDI83861.1 - 0.12 12.4 13.0 0.16 12.0 13.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.6 CDI83861.1 - 0.16 11.9 1.3 0.36 10.8 1.3 1.5 1 0 0 1 1 1 0 Protein Family FAM60A Spt20 PF12090.8 CDI83861.1 - 2.5 7.7 24.7 3.5 7.2 24.7 1.1 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 CDI83861.1 - 3.8 6.3 13.9 5 5.8 13.9 1.2 1 0 0 1 1 1 0 Androgen receptor Suf PF05843.14 CDI83861.1 - 4.1 7.3 9.4 9.6 6.1 9.1 1.7 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 CDI83861.1 - 9.8 7.2 8.4 21 6.2 8.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) NAM-associated PF14303.6 CDI83862.1 - 0.49 11.1 0.0 0.49 11.1 0.0 15.4 11 6 3 15 15 15 0 No apical meristem-associated C-terminal domain RabGAP-TBC PF00566.18 CDI83865.1 - 2.2e-18 66.7 0.1 4.6e-18 65.7 0.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SPRY PF00622.28 CDI83867.1 - 3.4e-13 49.8 0.0 5.2e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 CDI83867.1 - 0.0073 16.2 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 LisH zf-CCCH PF00642.24 CDI83868.1 - 1.9e-19 69.0 14.2 1.7e-08 34.2 1.7 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDI83868.1 - 2e-16 59.4 18.8 2e-06 27.7 3.4 3.6 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH_4 PF18044.1 CDI83868.1 - 3.8e-15 55.3 15.4 8.3e-06 25.5 1.1 3.9 4 0 0 4 4 4 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDI83868.1 - 4.3e-06 27.0 16.2 0.0033 17.9 1.8 3.7 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CDI83868.1 - 0.00012 22.8 6.7 0.0044 17.7 0.8 6.4 2 2 4 6 6 6 3 Torus domain Lustrin_cystein PF14625.6 CDI83868.1 - 3.6 8.0 17.7 1.8 9.0 0.2 3.9 3 1 1 4 4 4 0 Lustrin, cysteine-rich repeated domain Ribosomal_60s PF00428.19 CDI83871.1 - 2.3e-23 82.6 12.7 3.1e-23 82.2 12.7 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein K_channel_TID PF07941.11 CDI83871.1 - 0.018 15.5 8.3 0.028 14.9 8.3 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF812 PF05667.11 CDI83872.1 - 1.2 8.0 28.7 2.5 6.9 28.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FHA PF00498.26 CDI83874.1 - 7.1e-07 29.5 0.0 1.9e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDI83874.1 - 0.0074 16.6 0.0 0.034 14.5 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain ATP19 PF11022.8 CDI83874.1 - 0.73 10.3 0.1 0.73 10.3 0.1 4.0 4 0 0 4 4 4 0 ATP synthase subunit K Golgin_A5 PF09787.9 CDI83874.1 - 1.4 8.3 11.9 0.33 10.4 3.4 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 5 Methyltransf_25 PF13649.6 CDI83875.1 - 4.3e-07 30.5 0.1 4.3e-07 30.5 0.1 2.3 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDI83875.1 - 1.6e-06 28.6 0.0 1.6e-06 28.6 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDI83875.1 - 0.00031 20.6 0.2 0.00031 20.6 0.2 2.4 1 1 1 2 2 2 1 Methyltransferase domain AAA_23 PF13476.6 CDI83875.1 - 0.00093 19.7 5.7 0.0012 19.4 5.7 1.1 1 0 0 1 1 1 1 AAA domain DUF2076 PF09849.9 CDI83875.1 - 0.0013 18.9 9.7 0.0013 18.9 9.7 3.0 2 1 0 2 2 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Methyltransf_12 PF08242.12 CDI83875.1 - 0.0013 19.4 0.1 0.0013 19.4 0.1 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDI83875.1 - 0.0015 18.4 0.1 0.0015 18.4 0.1 2.6 1 1 1 2 2 1 1 Methyltransferase domain Spt20 PF12090.8 CDI83875.1 - 0.0021 17.7 15.0 0.0021 17.7 15.0 3.3 2 1 1 3 3 2 1 Spt20 family DUF2722 PF10846.8 CDI83875.1 - 0.0023 16.9 11.0 0.0023 16.9 11.0 3.3 2 1 1 3 3 2 1 Protein of unknown function (DUF2722) MTS PF05175.14 CDI83875.1 - 0.0075 15.8 0.0 0.02 14.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase small domain EarP PF10093.9 CDI83875.1 - 0.077 12.1 8.0 0.14 11.2 8.0 1.3 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP DUF3381 PF11861.8 CDI83875.1 - 0.11 12.3 6.5 0.36 10.6 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SLC12 PF03522.15 CDI83875.1 - 0.11 11.5 16.3 1.2 8.0 9.8 2.1 2 0 0 2 2 2 0 Solute carrier family 12 RskA PF10099.9 CDI83875.1 - 0.15 12.3 19.0 0.21 11.9 9.3 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Med15 PF09606.10 CDI83875.1 - 0.22 10.2 32.4 0.33 9.6 32.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Rtf2 PF04641.12 CDI83875.1 - 0.55 9.5 18.3 3.9 6.8 12.3 2.4 2 1 1 3 3 3 0 Rtf2 RING-finger PrmA PF06325.13 CDI83875.1 - 0.83 9.0 8.4 0.064 12.6 2.5 2.0 1 1 1 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Hid1 PF12722.7 CDI83875.1 - 4.5 5.3 18.2 6.9 4.7 18.2 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF5427 PF10310.9 CDI83875.1 - 6.8 5.5 26.2 0.19 10.7 0.5 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5427) RAP1 PF07218.11 CDI83876.1 - 0.12 10.7 8.8 0.13 10.5 8.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.9 CDI83876.1 - 0.48 9.2 6.2 0.56 9.0 6.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF2052 PF09747.9 CDI83877.1 - 0.069 13.3 6.8 0.11 12.6 0.7 2.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Folliculin PF11704.8 CDI83877.1 - 0.19 11.6 3.8 1 9.2 0.2 2.8 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport FAM176 PF14851.6 CDI83877.1 - 0.74 9.5 4.6 0.35 10.5 1.4 2.0 2 0 0 2 2 2 0 FAM176 family RNA_pol_3_Rpc31 PF11705.8 CDI83877.1 - 2.6 8.2 6.8 3.4 7.8 1.0 3.0 2 1 1 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 TAP42 PF04177.12 CDI83877.1 - 3.8 6.6 11.5 11 5.0 4.6 2.6 3 0 0 3 3 3 0 TAP42-like family DUF4746 PF15928.5 CDI83877.1 - 4.9 6.5 6.9 2.6 7.4 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Bystin PF05291.11 CDI83877.1 - 6.3 6.0 9.2 0.12 11.6 1.4 2.0 2 0 0 2 2 2 0 Bystin SNase PF00565.17 CDI83878.1 - 1.2e-08 35.4 2.1 3.6e-07 30.6 0.0 3.1 2 1 1 3 3 3 2 Staphylococcal nuclease homologue Gly-zipper_OmpA PF13436.6 CDI83879.1 - 0.00057 19.6 11.7 0.01 15.6 5.5 2.4 1 1 1 2 2 2 2 Glycine-zipper domain Gly-zipper_YMGG PF13441.6 CDI83879.1 - 0.3 10.8 6.0 3 7.6 6.0 2.3 1 1 0 1 1 1 0 YMGG-like Gly-zipper DNA_methylase PF00145.17 CDI83880.1 - 5.1e-36 124.7 0.0 2.2e-34 119.3 0.0 2.1 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Pkinase PF00069.25 CDI83881.1 - 1.9e-15 57.0 0.1 1.5e-13 50.8 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83881.1 - 5.7e-08 32.4 0.0 6.9e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDI83881.1 - 0.24 10.7 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like LCAT PF02450.15 CDI83882.1 - 8.8e-38 130.5 0.0 5.2e-37 128.0 0.0 1.9 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase ECM11 PF15463.6 CDI83882.1 - 0.14 12.7 0.4 0.23 12.0 0.4 1.3 1 0 0 1 1 1 0 Extracellular mutant protein 11 DUF2722 PF10846.8 CDI83883.1 - 0.00035 19.6 7.3 0.00035 19.6 7.3 5.6 5 0 0 5 5 5 4 Protein of unknown function (DUF2722) SUIM_assoc PF16619.5 CDI83884.1 - 0.89 9.7 0.0 0.89 9.7 0.0 15.0 9 4 3 12 12 12 0 Unstructured region C-term to UIM in Ataxin3 RskA PF10099.9 CDI83886.1 - 0.0018 18.6 17.5 0.0018 18.6 17.5 3.6 2 1 0 2 2 2 1 Anti-sigma-K factor rskA AT_hook PF02178.19 CDI83887.1 - 3.3 7.9 5.9 10 6.4 5.9 1.9 1 0 0 1 1 1 0 AT hook motif MACPF PF01823.19 CDI83890.1 - 1.1e-35 123.6 0.0 1.1e-35 123.6 0.0 3.3 4 0 0 4 4 4 1 MAC/Perforin domain EF-hand_7 PF13499.6 CDI83891.1 - 0.0023 18.4 0.1 0.045 14.2 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair VIT1 PF01988.19 CDI83891.1 - 0.0075 16.2 2.0 0.017 15.0 2.0 1.6 1 0 0 1 1 1 1 VIT family ABC_trans_N PF14510.6 CDI83891.1 - 0.029 15.0 0.0 0.11 13.2 0.0 2.0 1 0 0 1 1 1 0 ABC-transporter N-terminal EF-hand_8 PF13833.6 CDI83891.1 - 0.037 13.9 1.4 2.5 8.0 0.4 3.1 3 0 0 3 3 3 0 EF-hand domain pair AAA_2 PF07724.14 CDI83892.1 - 2.7e-39 135.0 0.0 3e-38 131.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDI83892.1 - 7.6e-24 83.6 2.1 1.6e-23 82.6 2.1 1.5 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 CDI83892.1 - 5.4e-22 78.6 0.0 7.8e-12 45.8 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDI83892.1 - 1.8e-13 51.3 0.7 4.9e-07 30.3 0.0 4.1 3 1 0 4 4 3 2 AAA ATPase domain ClpB_D2-small PF10431.9 CDI83892.1 - 5.5e-13 48.8 0.0 2.1e-12 46.9 0.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CDI83892.1 - 9.4e-13 48.3 1.2 1.4e-07 31.6 0.0 3.8 4 2 0 4 4 3 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDI83892.1 - 3.1e-09 36.7 0.2 2.5e-06 27.3 0.0 3.1 2 2 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 CDI83892.1 - 2.4e-07 31.1 2.8 0.01 16.1 0.1 5.2 2 2 1 3 3 3 1 AAA domain ATPase_2 PF01637.18 CDI83892.1 - 2.6e-07 30.8 3.6 0.29 11.0 0.0 4.2 3 1 1 4 4 4 3 ATPase domain predominantly from Archaea RuvB_N PF05496.12 CDI83892.1 - 3.9e-07 29.9 0.7 0.028 14.1 0.0 3.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 CDI83892.1 - 8e-07 28.7 0.5 0.032 13.7 0.2 4.3 3 1 0 3 3 3 1 Bacterial TniB protein Zeta_toxin PF06414.12 CDI83892.1 - 4.3e-06 26.1 3.6 0.0016 17.8 0.0 3.8 4 0 0 4 4 4 1 Zeta toxin AAA_7 PF12775.7 CDI83892.1 - 5.2e-06 26.1 0.0 0.023 14.2 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 CDI83892.1 - 1.4e-05 25.1 0.0 0.42 10.6 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CDI83892.1 - 1.8e-05 25.2 0.7 0.15 12.6 0.0 3.5 3 1 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 CDI83892.1 - 3e-05 24.0 0.2 0.28 11.1 0.0 2.6 3 0 0 3 3 2 2 RsgA GTPase TsaE PF02367.17 CDI83892.1 - 0.00011 22.2 0.2 0.24 11.4 0.0 2.9 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CDI83892.1 - 0.00012 22.2 0.0 0.092 13.0 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 CDI83892.1 - 0.0002 20.6 2.1 0.65 9.1 0.1 3.7 4 1 0 4 4 4 2 Protein of unknown function (DUF815) NACHT PF05729.12 CDI83892.1 - 0.00024 21.1 0.1 0.37 10.7 0.1 3.0 2 1 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 CDI83892.1 - 0.00051 19.8 0.0 0.62 9.8 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Bac_DnaA PF00308.18 CDI83892.1 - 0.00076 19.4 0.1 0.81 9.5 0.0 2.8 2 0 0 2 2 2 1 Bacterial dnaA protein RNA_helicase PF00910.22 CDI83892.1 - 0.001 19.4 0.0 1.8 9.0 0.0 2.8 2 0 0 2 2 2 1 RNA helicase TIP49 PF06068.13 CDI83892.1 - 0.005 16.1 0.7 0.8 8.8 0.1 2.5 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_19 PF13245.6 CDI83892.1 - 0.0054 17.1 0.3 0.52 10.6 0.4 3.0 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CDI83892.1 - 0.0067 16.9 0.5 0.7 10.4 0.0 3.0 2 1 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 CDI83892.1 - 0.0076 16.0 0.0 5.1 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 CDI83892.1 - 0.0093 16.0 0.5 2.6 8.0 0.0 4.1 4 1 1 5 5 5 1 Type III restriction enzyme, res subunit AAA_33 PF13671.6 CDI83892.1 - 0.012 15.8 2.7 2 8.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_3 PF07726.11 CDI83892.1 - 0.014 15.3 0.1 25 4.7 0.0 3.8 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDI83892.1 - 0.015 14.7 0.2 2.5 7.4 0.0 2.8 4 0 0 4 4 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDI83892.1 - 0.024 14.9 0.0 12 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDI83892.1 - 0.031 14.0 0.2 1.7 8.3 0.3 2.9 2 1 0 2 2 2 0 AAA domain Torsin PF06309.11 CDI83892.1 - 0.033 14.3 0.0 0.16 12.0 0.0 2.2 2 0 0 2 2 1 0 Torsin NTPase_1 PF03266.15 CDI83892.1 - 0.035 14.0 0.4 9 6.2 0.1 2.9 2 1 1 3 3 3 0 NTPase PduV-EutP PF10662.9 CDI83892.1 - 0.047 13.4 0.0 1.5 8.6 0.0 2.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 CDI83892.1 - 0.073 13.5 0.0 16 5.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain DNA_pol3_delta2 PF13177.6 CDI83892.1 - 0.15 11.9 0.0 2 8.2 0.0 2.6 2 1 0 2 2 2 0 DNA polymerase III, delta subunit AAA_25 PF13481.6 CDI83892.1 - 0.15 11.7 0.5 1.4 8.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 CDI83892.1 - 0.38 10.5 3.1 18 5.1 0.0 3.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain Ins145_P3_rec PF08709.11 CDI83893.1 - 0.084 12.0 0.0 7.2 5.7 0.0 2.5 2 1 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor PmoA PF14100.6 CDI83895.1 - 0.052 13.1 0.1 0.097 12.2 0.1 1.4 1 0 0 1 1 1 0 Methane oxygenase PmoA GBP PF02263.19 CDI83895.1 - 0.95 8.7 4.4 0.3 10.3 0.8 2.0 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain DUF1492 PF07374.11 CDI83896.1 - 1.1 9.5 3.9 0.82 9.9 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) DUF1623 PF07785.11 CDI83896.1 - 1.9 8.7 3.8 33 4.7 0.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1623) AP2 PF00847.20 CDI83897.1 - 6.7e-05 23.0 0.6 0.0047 17.1 0.1 3.0 2 0 0 2 2 2 1 AP2 domain TFIIA PF03153.13 CDI83897.1 - 0.0013 18.8 50.7 0.039 14.0 26.1 2.5 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF913 PF06025.12 CDI83897.1 - 0.006 15.6 2.8 0.006 15.6 2.8 2.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) DcuA_DcuB PF03605.14 CDI83897.1 - 0.014 14.3 1.1 0.028 13.3 1.1 1.4 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Connexin PF00029.19 CDI83897.1 - 0.015 15.1 1.1 0.015 15.1 1.1 2.1 2 0 0 2 2 2 0 Connexin Lin-8 PF03353.15 CDI83897.1 - 0.15 11.6 19.0 0.024 14.2 5.8 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF2722 PF10846.8 CDI83897.1 - 0.34 9.8 44.3 0.57 9.1 4.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) PAT1 PF09770.9 CDI83897.1 - 0.38 9.0 38.2 0.024 12.9 18.7 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 MCU PF04678.13 CDI83897.1 - 0.82 9.8 14.9 0.073 13.2 6.5 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter eIF-3_zeta PF05091.12 CDI83897.1 - 1.7 7.6 27.7 0.08 11.9 9.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) OmpH PF03938.14 CDI83897.1 - 1.9 8.8 50.7 2.5 8.4 14.4 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Suf PF05843.14 CDI83897.1 - 2.3 8.1 31.2 0.59 10.1 11.8 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Pal1 PF08316.11 CDI83897.1 - 2.8 8.7 14.0 3.9 8.2 1.1 2.8 2 0 0 2 2 2 0 Pal1 cell morphology protein Neur_chan_memb PF02932.16 CDI83897.1 - 4.3 7.3 14.5 0.25 11.4 1.7 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 CDI83897.1 - 4.4 6.1 4.4 7.4 5.4 4.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Velvet PF11754.8 CDI83897.1 - 5.4 6.9 21.7 0.6 10.0 8.9 2.5 2 0 0 2 2 2 0 Velvet factor zf-P11 PF03854.14 CDI83897.1 - 5.6 6.7 11.1 10 5.9 11.1 1.4 1 0 0 1 1 1 0 P-11 zinc finger ABC2_membrane_2 PF12679.7 CDI83897.1 - 9.9 5.3 5.8 1.4 8.1 0.6 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein Shikimate_dh_N PF08501.11 CDI83898.1 - 5.1e-07 29.9 0.0 3.4e-06 27.2 0.0 2.6 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 CDI83898.1 - 0.0027 17.8 0.1 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SKI PF01202.22 CDI83898.1 - 0.013 15.6 0.2 0.013 15.6 0.2 3.8 3 1 0 3 3 3 0 Shikimate kinase RNase_PH_C PF03725.15 CDI83900.1 - 0.00023 21.1 0.0 0.00046 20.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SUIM_assoc PF16619.5 CDI83900.1 - 0.017 15.2 0.0 0.017 15.2 0.0 7.0 4 2 1 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 CCDC-167 PF15188.6 CDI83900.1 - 0.14 12.5 0.2 0.14 12.5 0.2 2.6 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 Pox_G7 PF05503.12 CDI83900.1 - 0.9 8.4 3.9 1.9 7.3 3.9 1.5 1 0 0 1 1 1 0 Poxvirus G7-like FANCAA PF15146.6 CDI83900.1 - 1.1 8.2 16.9 0.21 10.6 12.6 2.0 2 0 0 2 2 2 0 Fanconi anemia-associated CDC27 PF09507.10 CDI83900.1 - 3 7.1 29.4 0.083 12.3 19.5 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 SLC12 PF03522.15 CDI83900.1 - 5 6.0 17.7 2.1 7.3 12.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 DUF4667 PF15700.5 CDI83900.1 - 8.7 6.4 19.7 4.5 7.3 14.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) SWI-SNF_Ssr4 PF08549.10 CDI83900.1 - 9.2 4.8 31.1 0.29 9.7 21.7 2.2 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) PAT1 PF09770.9 CDI83901.1 - 0.0011 17.3 33.8 0.0011 17.3 33.8 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 UPF0564 PF10595.9 CDI83901.1 - 0.0079 15.3 33.1 0.0094 15.0 33.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 RR_TM4-6 PF06459.12 CDI83901.1 - 0.013 15.4 29.2 0.017 14.9 29.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5523 PF17661.1 CDI83901.1 - 0.014 15.1 21.2 0.021 14.5 21.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5523) MarC PF01914.17 CDI83901.1 - 0.015 14.7 1.1 0.015 14.7 1.1 2.2 1 1 1 2 2 1 0 MarC family integral membrane protein SLC12 PF03522.15 CDI83901.1 - 0.02 13.9 23.3 0.024 13.7 23.3 1.3 1 0 0 1 1 1 0 Solute carrier family 12 AAA_23 PF13476.6 CDI83901.1 - 0.026 15.0 22.1 0.03 14.8 22.1 1.1 1 0 0 1 1 1 0 AAA domain SWI-SNF_Ssr4 PF08549.10 CDI83901.1 - 0.027 13.1 38.2 0.034 12.8 38.2 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) GREB1 PF15782.5 CDI83901.1 - 0.034 11.3 31.1 0.041 11.0 31.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LAP1C PF05609.12 CDI83901.1 - 0.044 12.9 30.7 0.053 12.6 30.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF572 PF04502.13 CDI83901.1 - 0.046 13.4 24.8 0.058 13.0 24.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) eIF-3_zeta PF05091.12 CDI83901.1 - 0.047 12.7 31.1 0.06 12.3 31.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SOBP PF15279.6 CDI83901.1 - 0.065 13.8 27.9 0.081 13.5 27.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CDK5_activator PF03261.15 CDI83901.1 - 0.076 12.5 23.9 0.1 12.1 23.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein GET2 PF08690.10 CDI83901.1 - 0.083 12.6 25.2 0.11 12.2 25.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Asp-B-Hydro_N PF05279.11 CDI83901.1 - 0.092 12.8 14.3 0.11 12.5 14.3 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Exonuc_VII_L PF02601.15 CDI83901.1 - 0.098 12.2 21.2 0.12 12.0 21.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit MCM_bind PF09739.9 CDI83901.1 - 0.1 11.0 22.3 0.13 10.6 22.3 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF2052 PF09747.9 CDI83901.1 - 0.12 12.5 21.3 0.16 12.1 21.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF3523 PF12037.8 CDI83901.1 - 0.15 11.4 36.2 0.24 10.7 36.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) CDC45 PF02724.14 CDI83901.1 - 0.16 10.3 22.4 0.18 10.0 22.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2126 PF09899.9 CDI83901.1 - 0.2 9.7 13.4 0.23 9.5 13.4 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) NARP1 PF12569.8 CDI83901.1 - 0.23 10.3 23.8 0.3 9.9 23.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ALMT PF11744.8 CDI83901.1 - 0.24 10.2 21.3 0.28 10.0 21.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Utp14 PF04615.13 CDI83901.1 - 0.36 9.3 28.9 0.4 9.2 28.9 1.0 1 0 0 1 1 1 0 Utp14 protein SID-1_RNA_chan PF13965.6 CDI83901.1 - 0.67 8.3 11.3 1.1 7.6 11.3 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CRT10 PF08728.10 CDI83901.1 - 0.67 8.0 13.8 0.75 7.9 13.8 1.0 1 0 0 1 1 1 0 CRT10 VIT1 PF01988.19 CDI83901.1 - 0.74 9.6 17.4 1.6 8.6 17.4 1.6 1 1 0 1 1 1 0 VIT family CAC1F_C PF16885.5 CDI83901.1 - 0.75 9.4 22.5 0.9 9.1 22.5 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Joubert PF15392.6 CDI83901.1 - 0.77 9.4 30.5 1 9.0 30.5 1.2 1 0 0 1 1 1 0 Joubert syndrome-associated PA26 PF04636.13 CDI83901.1 - 0.77 8.6 19.6 0.9 8.4 19.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CDC27 PF09507.10 CDI83901.1 - 0.79 9.0 32.2 1 8.7 32.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Cellulose_synt PF03552.14 CDI83901.1 - 0.82 8.1 7.7 0.93 7.9 7.7 1.2 1 0 0 1 1 1 0 Cellulose synthase SelP_N PF04592.14 CDI83901.1 - 0.83 9.0 27.9 1.3 8.4 27.9 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Myc_N PF01056.18 CDI83901.1 - 0.87 9.4 21.5 1.1 9.1 21.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF4746 PF15928.5 CDI83901.1 - 0.94 8.8 17.7 1.3 8.4 17.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) YfhO PF09586.10 CDI83901.1 - 1.1 7.4 12.6 1.3 7.2 12.6 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO XRN_M PF17846.1 CDI83901.1 - 1.3 7.9 17.4 1.5 7.6 17.4 1.3 1 0 0 1 1 1 0 Xrn1 helical domain DUF3292 PF11696.8 CDI83901.1 - 1.3 7.3 16.6 1.7 6.9 16.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Serinc PF03348.15 CDI83901.1 - 1.4 7.8 18.1 2.3 7.1 18.1 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hamartin PF04388.12 CDI83901.1 - 1.5 7.4 31.6 1.9 7.1 31.6 1.1 1 0 0 1 1 1 0 Hamartin protein SR-25 PF10500.9 CDI83901.1 - 1.5 8.3 51.6 0.21 11.2 29.5 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein FemAB PF02388.16 CDI83901.1 - 1.7 7.5 20.5 2.1 7.1 20.5 1.2 1 0 0 1 1 1 0 FemAB family SOG2 PF10428.9 CDI83901.1 - 1.8 7.7 33.5 2.4 7.3 33.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein PPP4R2 PF09184.11 CDI83901.1 - 2 8.0 26.8 2.5 7.6 26.8 1.1 1 0 0 1 1 1 0 PPP4R2 FapA PF03961.13 CDI83901.1 - 2.1 6.9 13.0 2.5 6.6 13.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A RIFIN PF02009.16 CDI83901.1 - 2.3 8.0 25.0 5.8 6.7 25.0 1.8 1 1 0 1 1 1 0 Rifin SprA-related PF12118.8 CDI83901.1 - 2.5 7.2 64.1 0.7 9.0 61.6 1.3 1 1 0 1 1 1 0 SprA-related family VIR_N PF15912.5 CDI83901.1 - 2.7 7.5 17.0 3.6 7.1 17.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Radical_SAM_N PF08497.10 CDI83901.1 - 2.8 7.1 12.3 3.6 6.7 12.3 1.2 1 0 0 1 1 1 0 Radical SAM N-terminal Smg8_Smg9 PF10220.9 CDI83901.1 - 3 6.1 24.6 3.6 5.8 24.6 1.2 1 0 0 1 1 1 0 Smg8_Smg9 Nop53 PF07767.11 CDI83901.1 - 3.2 7.1 34.2 4.2 6.7 34.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) SAPS PF04499.15 CDI83901.1 - 3.5 6.3 24.0 4.4 6.0 24.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein HAUS6_N PF14661.6 CDI83901.1 - 4.6 6.8 26.1 6.2 6.3 26.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Hid1 PF12722.7 CDI83901.1 - 7.8 4.5 32.8 9.8 4.2 32.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF3_subunit PF08597.10 CDI83901.1 - 8.1 6.3 29.3 12 5.7 29.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Borrelia_P83 PF05262.11 CDI83901.1 - 8.5 4.7 24.2 10 4.5 24.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2052 PF09747.9 CDI83903.1 - 2.4e-27 96.4 70.8 4.3e-13 49.8 46.3 4.1 2 1 1 3 3 3 3 Coiled-coil domain containing protein (DUF2052) EF-1_beta_acid PF10587.9 CDI83904.1 - 7.4 7.1 7.1 1e+02 3.5 7.1 3.2 1 1 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region SUIM_assoc PF16619.5 CDI83905.1 - 0.16 12.1 6.8 0.44 10.6 6.8 1.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Sin_N PF04801.13 CDI83905.1 - 1.1 8.4 5.7 12 5.0 0.0 2.3 2 0 0 2 2 2 0 Sin-like protein conserved region TFIIA PF03153.13 CDI83905.1 - 1.4 8.8 13.4 0.24 11.4 9.1 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI83905.1 - 3.2 6.4 6.8 5.8 5.6 6.8 1.4 1 0 0 1 1 1 0 Presenilin Totivirus_coat PF05518.11 CDI83905.1 - 5.5 4.9 16.4 8.9 4.2 16.4 1.2 1 0 0 1 1 1 0 Totivirus coat protein tRNA-synt_2 PF00152.20 CDI83906.1 - 2e-40 138.8 0.0 2.3e-40 138.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CDI83906.1 - 0.00035 20.1 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) COX15-CtaA PF02628.15 CDI83907.1 - 5e-51 173.7 8.2 3.4e-36 124.9 2.5 2.0 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein AChE_tetra PF08674.10 CDI83907.1 - 0.082 12.6 1.5 0.15 11.8 1.5 1.4 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain DUF773 PF05600.12 CDI83908.1 - 1.4e-48 165.9 22.0 1.8e-48 165.6 22.0 1.1 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 FCSD-flav_bind PF09242.11 CDI83908.1 - 2.3 8.7 4.3 53 4.3 0.0 2.9 2 0 0 2 2 2 0 Flavocytochrome c sulphide dehydrogenase, flavin-binding EF-hand_1 PF00036.32 CDI83909.1 - 3.3e-28 95.1 13.4 2.7e-08 32.8 2.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDI83909.1 - 1.8e-27 95.6 10.0 3.3e-15 56.3 3.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDI83909.1 - 2.5e-26 89.3 7.6 1.9e-06 27.4 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDI83909.1 - 6.4e-20 70.8 7.0 7e-14 51.4 1.4 2.7 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 CDI83909.1 - 4e-14 52.7 0.6 1.4e-06 28.5 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDI83909.1 - 3.8e-07 29.3 10.5 1.9e-05 23.9 1.2 4.4 4 1 0 4 4 4 2 EF hand EF-hand_4 PF12763.7 CDI83909.1 - 1.6e-06 28.0 2.7 0.006 16.5 0.8 2.5 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 CDI83909.1 - 0.00013 22.2 2.9 0.31 11.4 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain Caleosin PF05042.13 CDI83909.1 - 0.0045 16.9 2.7 23 4.9 0.1 3.8 1 1 3 4 4 4 0 Caleosin related protein SurA_N_2 PF13623.6 CDI83909.1 - 0.015 15.2 2.8 1.6 8.6 0.2 2.6 1 1 2 3 3 3 0 SurA N-terminal domain Prefoldin_3 PF13758.6 CDI83909.1 - 0.039 14.0 1.0 0.6 10.2 0.2 2.2 1 1 1 2 2 2 0 Prefoldin subunit DUF2401 PF10287.9 CDI83909.1 - 0.11 12.1 0.2 0.14 11.7 0.2 1.2 1 0 0 1 1 1 0 Putative TOS1-like glycosyl hydrolase (DUF2401) T4SS_TraI PF16932.5 CDI83909.1 - 0.29 10.3 1.5 12 5.0 0.0 2.4 2 1 1 3 3 3 0 Type IV secretory system, conjugal DNA-protein transfer EF-hand_10 PF14788.6 CDI83909.1 - 0.36 10.7 3.3 0.26 11.2 0.3 2.2 2 0 0 2 2 2 0 EF hand Mst1_SARAH PF11629.8 CDI83909.1 - 0.72 10.0 4.4 0.56 10.3 1.7 2.2 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 DUF92 PF01940.16 CDI83910.1 - 0.78 9.1 14.9 0.056 12.9 0.9 2.6 1 1 0 2 2 2 0 Integral membrane protein DUF92 FAP PF07174.11 CDI83910.1 - 1.2 8.5 27.3 2.2 7.7 27.3 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Utp14 PF04615.13 CDI83910.1 - 8.1 4.9 50.6 9 4.7 50.6 1.0 1 0 0 1 1 1 0 Utp14 protein CLN3 PF02487.17 CDI83911.1 - 0.0059 15.7 1.7 0.0059 15.7 1.7 1.9 2 0 0 2 2 2 1 CLN3 protein Peptidase_S49_N PF08496.10 CDI83911.1 - 0.63 10.1 9.2 1.1 9.4 9.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TFIIA PF03153.13 CDI83911.1 - 0.64 10.0 48.7 0.89 9.5 48.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI83911.1 - 1 8.3 17.9 0.017 14.1 11.3 1.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DNA_pol3_a_NII PF11490.8 CDI83911.1 - 1.4 8.8 21.6 3.2 7.7 21.6 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II DUF2232 PF09991.9 CDI83911.1 - 1.7 7.8 3.1 2 7.5 3.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF4407 PF14362.6 CDI83911.1 - 2 7.7 19.1 2.7 7.2 19.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RskA PF10099.9 CDI83911.1 - 2.9 8.2 41.9 9.6 6.5 41.9 1.9 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Sec16 PF12932.7 CDI83913.1 - 4.5 7.9 20.3 1.3 9.6 2.2 4.9 4 0 0 4 4 4 0 Vesicle coat trafficking protein Sec16 mid-region Pkinase PF00069.25 CDI83914.1 - 4.4e-40 137.7 0.0 4.4e-40 137.7 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83914.1 - 2e-34 119.1 0.0 2e-34 119.1 0.0 2.9 3 0 0 3 3 3 1 Protein tyrosine kinase Spt20 PF12090.8 CDI83915.1 - 0.12 12.0 43.1 0.19 11.3 4.5 2.2 2 0 0 2 2 2 0 Spt20 family MTABC_N PF16185.5 CDI83915.1 - 0.27 10.7 1.3 0.42 10.1 0.4 1.9 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region FAM60A PF15396.6 CDI83915.1 - 0.31 11.0 12.4 1.8 8.5 2.0 2.2 2 0 0 2 2 2 0 Protein Family FAM60A CTU2 PF10288.9 CDI83915.1 - 0.33 11.2 19.0 1.5 9.1 3.0 2.5 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Macoilin PF09726.9 CDI83915.1 - 1.1 7.8 26.2 0.25 9.9 12.0 2.4 2 0 0 2 2 2 0 Macoilin family Ribosomal_60s PF00428.19 CDI83915.1 - 2.1 9.0 42.1 5.6 7.6 12.8 3.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein Connexin PF00029.19 CDI83915.1 - 3.1 7.5 6.3 2.5 7.8 3.0 2.0 2 0 0 2 2 2 0 Connexin DUF4667 PF15700.5 CDI83915.1 - 3.5 7.6 33.1 0.071 13.2 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Serinc PF03348.15 CDI83915.1 - 3.8 6.3 18.4 0.028 13.4 4.7 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF5123 PF17161.4 CDI83915.1 - 4.3 8.5 9.0 0.24 12.5 3.5 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF5123) Sin_N PF04801.13 CDI83915.1 - 5.3 6.1 21.3 1.2 8.3 12.6 2.2 2 0 0 2 2 2 0 Sin-like protein conserved region Presenilin PF01080.17 CDI83915.1 - 5.8 5.6 19.8 0.77 8.4 6.2 2.2 2 0 0 2 2 2 0 Presenilin FAM176 PF14851.6 CDI83915.1 - 6.7 6.4 9.3 0.61 9.7 1.3 2.4 2 0 0 2 2 2 0 FAM176 family YABBY PF04690.13 CDI83915.1 - 7.2 7.2 14.8 2.7 8.5 3.2 2.5 2 0 0 2 2 2 0 YABBY protein SID-1_RNA_chan PF13965.6 CDI83915.1 - 8.1 4.7 9.7 1.4 7.3 0.6 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF572 PF04502.13 CDI83915.1 - 9.2 5.8 19.3 0.26 10.8 1.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Fcf1 PF04900.12 CDI83916.1 - 4.3e-16 59.1 5.4 1.3e-08 35.1 0.0 3.7 3 0 0 3 3 3 2 Fcf1 DSPc PF00782.20 CDI83916.1 - 7.4e-06 25.8 0.0 3.4e-05 23.7 0.0 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDI83916.1 - 8e-05 22.7 0.3 0.00045 20.3 0.2 2.2 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 CDI83916.1 - 0.087 12.4 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family MORN PF02493.20 CDI83917.1 - 8.8e-46 151.1 64.3 3.3e-07 29.8 1.5 9.8 10 0 0 10 10 10 9 MORN repeat BAF1_ABF1 PF04684.13 CDI83917.1 - 0.049 12.7 11.1 0.066 12.3 11.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Nup153 PF08604.10 CDI83917.1 - 0.076 11.8 6.0 0.1 11.4 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup153-like Spt20 PF12090.8 CDI83917.1 - 0.51 9.9 22.9 0.77 9.3 22.9 1.2 1 0 0 1 1 1 0 Spt20 family Gag_spuma PF03276.14 CDI83917.1 - 0.55 8.6 11.0 0.74 8.2 11.0 1.1 1 0 0 1 1 1 0 Spumavirus gag protein SprA-related PF12118.8 CDI83917.1 - 0.69 9.0 20.3 0.97 8.5 20.3 1.2 1 0 0 1 1 1 0 SprA-related family eIF-3_zeta PF05091.12 CDI83917.1 - 1.2 8.0 12.6 1.7 7.5 12.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Tudor_2 PF18104.1 CDI83917.1 - 1.3 8.8 11.5 1.9 8.2 0.0 4.7 5 0 0 5 5 5 0 Jumonji domain-containing protein 2A Tudor domain RR_TM4-6 PF06459.12 CDI83917.1 - 1.5 8.6 13.1 2.2 8.0 13.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Herpes_UL32 PF06070.11 CDI83917.1 - 2.7 5.6 9.8 4.5 4.9 9.8 1.3 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 DUF4746 PF15928.5 CDI83917.1 - 2.8 7.3 10.4 4.1 6.8 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIP PF07454.11 CDI83917.1 - 6.4 6.1 11.6 9.9 5.5 11.6 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 CDI83917.1 - 7.2 6.8 11.9 12 6.0 11.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal HD_3 PF13023.6 CDI83918.1 - 6.7e-26 91.2 0.2 7.6e-26 91.0 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CDI83918.1 - 3.1e-08 33.6 0.4 1.1e-07 31.8 0.3 1.7 1 1 1 2 2 2 1 HD containing hydrolase-like enzyme HD PF01966.22 CDI83918.1 - 0.0081 16.4 0.1 0.023 14.9 0.1 1.7 1 1 0 1 1 1 1 HD domain PRONE PF03759.13 CDI83918.1 - 0.026 13.4 0.0 0.026 13.4 0.0 1.1 1 0 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) ABC1 PF03109.16 CDI83920.1 - 3.3e-29 101.4 0.0 6.6e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Spt20 PF12090.8 CDI83920.1 - 0.0017 18.0 9.9 0.0017 18.0 9.9 7.0 7 1 0 7 7 7 2 Spt20 family RskA PF10099.9 CDI83920.1 - 0.002 18.4 79.1 0.062 13.6 4.8 8.5 8 1 0 8 8 8 6 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI83920.1 - 0.0028 17.7 5.5 0.0028 17.7 5.5 8.7 7 1 0 7 7 7 1 Unstructured region C-term to UIM in Ataxin3 APH PF01636.23 CDI83920.1 - 0.23 11.3 0.0 0.23 11.3 0.0 5.0 7 0 0 7 7 7 0 Phosphotransferase enzyme family FpoO PF10621.9 CDI83920.1 - 0.86 9.9 3.3 1.2 9.4 0.3 2.6 2 0 0 2 2 2 0 F420H2 dehydrogenase subunit FpoO Pex2_Pex12 PF04757.14 CDI83922.1 - 1.8e-06 27.7 0.0 9.7e-06 25.3 0.0 2.1 1 1 1 2 2 2 1 Pex2 / Pex12 amino terminal region PGA2 PF07543.12 CDI83922.1 - 0.7 9.9 3.8 4 7.4 2.0 2.4 2 0 0 2 2 2 0 Protein trafficking PGA2 RRP36 PF06102.12 CDI83923.1 - 9.5e-24 84.2 23.0 9.5e-24 84.2 23.0 2.3 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 BUD22 PF09073.10 CDI83924.1 - 0.00013 21.4 5.9 0.00013 21.4 5.9 5.0 2 1 2 5 5 5 2 BUD22 ANAPC_CDC26 PF10471.9 CDI83924.1 - 0.044 14.6 1.2 0.044 14.6 1.2 11.2 5 3 5 10 10 10 0 Anaphase-promoting complex APC subunit CDC26 MT-A70 PF05063.14 CDI83926.1 - 2.7e-15 56.7 0.0 3.4e-12 46.6 0.0 2.7 1 1 1 2 2 2 2 MT-A70 DUF3446 PF11928.8 CDI83926.1 - 0.48 10.7 8.0 2.3 8.6 8.0 2.1 1 0 0 1 1 1 0 Early growth response N-terminal domain RRM_1 PF00076.22 CDI83927.1 - 6.1e-16 58.0 0.0 7.7e-16 57.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDI83927.1 - 0.00088 18.9 0.0 0.001 18.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPX PF03105.19 CDI83928.1 - 0.0019 18.2 9.8 0.0019 18.2 9.8 6.5 4 2 0 4 4 4 1 SPX domain Nop53 PF07767.11 CDI83929.1 - 3.9e-20 72.6 32.8 5.2e-20 72.2 32.8 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) RAP PF08373.10 CDI83930.1 - 1.9e-07 31.0 0.1 0.00018 21.5 0.1 2.5 2 0 0 2 2 2 2 RAP domain MTES_1575 PF18741.1 CDI83930.1 - 0.00051 20.2 0.1 0.057 13.6 0.0 3.0 2 1 0 2 2 2 1 REase_MTES_1575 EphA2_TM PF14575.6 CDI83930.1 - 0.065 14.1 4.8 0.64 10.9 0.9 3.3 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain AAA_23 PF13476.6 CDI83930.1 - 0.25 11.8 0.0 0.25 11.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain 6PGD PF00393.19 CDI83931.1 - 1.7e-48 165.5 0.3 3.3e-48 164.6 0.1 1.6 2 0 0 2 2 2 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CDI83931.1 - 3.3e-43 147.6 0.0 5.1e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CDI83931.1 - 0.037 13.9 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 CDI83931.1 - 0.11 12.8 0.6 11 6.3 0.0 2.4 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Topoisom_I PF01028.20 CDI83931.1 - 0.14 11.4 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core AAA PF00004.29 CDI83932.1 - 8.2e-36 123.3 0.0 3.3e-35 121.4 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDI83932.1 - 7e-08 32.4 0.0 2e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CDI83932.1 - 0.001 19.6 1.5 0.0026 18.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CDI83932.1 - 0.006 16.6 0.1 0.049 13.6 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDI83932.1 - 0.0075 16.4 0.0 0.0075 16.4 0.0 4.2 3 1 1 4 4 2 1 AAA domain TIP49 PF06068.13 CDI83932.1 - 0.01 15.1 1.2 0.013 14.7 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_14 PF13173.6 CDI83932.1 - 0.017 15.2 0.1 0.057 13.4 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_2 PF07724.14 CDI83932.1 - 0.019 15.1 0.0 0.019 15.1 0.0 3.1 3 0 0 3 3 2 0 AAA domain (Cdc48 subfamily) NUDIX PF00293.28 CDI83932.1 - 0.021 14.9 1.1 0.062 13.3 0.0 2.3 2 0 0 2 2 2 0 NUDIX domain AAA_25 PF13481.6 CDI83932.1 - 0.023 14.2 0.9 0.93 9.0 0.5 2.7 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 CDI83932.1 - 0.034 14.4 0.0 0.034 14.4 0.0 4.2 3 2 1 5 5 4 0 AAA domain MMR_HSR1 PF01926.23 CDI83932.1 - 0.041 14.0 0.0 0.15 12.1 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase PEPCK_ATP PF01293.20 CDI83932.1 - 0.072 11.8 0.1 0.16 10.6 0.1 1.5 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase TsaE PF02367.17 CDI83932.1 - 0.11 12.5 0.2 0.65 10.0 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 CDI83932.1 - 0.54 10.4 0.0 0.54 10.4 0.0 3.7 3 1 0 4 4 2 0 Shikimate kinase AAA_28 PF13521.6 CDI83932.1 - 0.68 10.2 0.0 0.68 10.2 0.0 4.8 6 1 0 6 6 4 0 AAA domain AAA_17 PF13207.6 CDI83932.1 - 1 9.8 0.0 1 9.8 0.0 3.0 3 0 0 3 3 2 0 AAA domain Flavodoxin_1 PF00258.25 CDI83934.1 - 2.7e-20 73.0 0.5 2.2e-16 60.3 0.0 3.3 2 0 0 2 2 2 2 Flavodoxin FAD_binding_1 PF00667.20 CDI83934.1 - 1.3e-09 38.0 0.1 0.00084 19.0 0.0 4.3 4 0 0 4 4 4 3 FAD binding domain DUF2722 PF10846.8 CDI83934.1 - 7.2e-05 21.9 57.4 0.013 14.5 4.0 5.2 5 0 0 5 5 5 4 Protein of unknown function (DUF2722) NAD_binding_1 PF00175.21 CDI83934.1 - 0.00016 22.3 14.4 0.00017 22.2 0.0 4.3 4 0 0 4 4 4 2 Oxidoreductase NAD-binding domain MecA PF05389.12 CDI83934.1 - 0.052 13.2 13.2 0.2 11.3 1.4 4.6 4 0 0 4 4 4 0 Negative regulator of genetic competence (MecA) Mgr1 PF08602.10 CDI83934.1 - 0.14 11.0 3.1 0.63 8.8 3.1 2.1 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Septin PF00735.18 CDI83934.1 - 1.7 7.8 0.0 1.7 7.8 0.0 2.9 4 0 0 4 4 4 0 Septin CAF1 PF04857.20 CDI83934.1 - 3.1 6.9 11.3 0.88 8.7 1.7 3.2 3 0 0 3 3 3 0 CAF1 family ribonuclease SAC3_GANP PF03399.16 CDI83935.1 - 6.8e-13 48.6 0.0 6.8e-13 48.6 0.0 5.4 6 0 0 6 6 6 2 SAC3/GANP family Amidase PF01425.21 CDI83936.1 - 1.7e-06 27.3 0.9 0.0088 15.0 0.0 2.8 2 1 0 2 2 2 2 Amidase PsbQ PF05757.11 CDI83936.1 - 0.11 12.3 7.0 0.39 10.4 7.0 2.1 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) Guanylate_cyc PF00211.20 CDI83937.1 - 2.2e-36 125.2 0.0 2.5e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Flavoprotein PF02441.19 CDI83940.1 - 6.7e-17 61.7 0.0 8.5e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein DUF533 PF04391.12 CDI83940.1 - 0.0065 16.1 0.3 0.0078 15.8 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF533) CorA PF01544.18 CDI83942.1 - 0.019 14.3 3.6 0.077 12.3 3.7 1.9 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Methyltransf_34 PF11312.8 CDI83942.1 - 0.61 9.3 3.6 0.17 11.1 0.5 1.6 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase RskA PF10099.9 CDI83943.1 - 0.02 15.2 29.2 0.023 15.0 0.8 3.7 2 1 1 3 3 3 0 Anti-sigma-K factor rskA Vma12 PF11712.8 CDI83943.1 - 1.6 8.8 4.2 4.6 7.3 4.2 1.8 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase zf-C3HC4_2 PF13923.6 CDI83944.1 - 4.2e-10 39.3 10.0 9.2e-10 38.2 10.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDI83944.1 - 7.9e-08 32.5 8.5 1.7e-07 31.5 8.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDI83944.1 - 1.8e-07 30.9 10.1 3.4e-07 30.0 10.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDI83944.1 - 3.2e-07 30.1 9.7 6.9e-07 29.0 9.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDI83944.1 - 8.9e-07 28.8 9.4 2.6e-06 27.4 9.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDI83944.1 - 1e-06 28.6 6.5 2.2e-06 27.5 6.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CDI83944.1 - 3.8e-05 23.9 3.4 3.8e-05 23.9 3.4 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain U-box PF04564.15 CDI83944.1 - 3.9e-05 23.7 0.2 8.9e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 U-box domain zf-C3HC4_4 PF15227.6 CDI83944.1 - 5.9e-05 23.1 10.8 0.00015 21.9 10.8 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CDI83944.1 - 0.0059 16.5 11.7 0.012 15.4 11.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 LON_substr_bdg PF02190.16 CDI83944.1 - 0.0063 16.4 0.0 0.018 14.9 0.0 1.8 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain K_channel_TID PF07941.11 CDI83944.1 - 0.0089 16.5 6.8 0.0089 16.5 6.8 7.4 7 3 1 8 8 3 1 Potassium channel Kv1.4 tandem inactivation domain DUF2722 PF10846.8 CDI83944.1 - 0.0092 15.0 10.7 0.022 13.7 1.9 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI83944.1 - 0.0099 15.5 3.8 0.0099 15.5 3.8 2.4 2 0 0 2 2 2 1 Spt20 family zf-RING_10 PF16685.5 CDI83944.1 - 0.01 15.9 9.0 0.021 14.9 9.0 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 CDI83944.1 - 0.013 15.3 3.4 0.032 14.0 3.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 CDI83944.1 - 0.049 13.5 6.5 0.11 12.4 6.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein ADP_PFK_GK PF04587.15 CDI83944.1 - 0.71 8.4 3.9 12 4.3 0.8 2.4 2 0 0 2 2 2 0 ADP-specific Phosphofructokinase/Glucokinase conserved region SARAF PF06682.12 CDI83944.1 - 1.4 8.5 4.7 2.7 7.5 1.8 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 CDI83944.1 - 1.9 9.5 8.2 0.47 11.4 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AIF_C PF14721.6 CDI83944.1 - 2.5 8.4 0.0 2.5 8.4 0.0 2.6 3 0 0 3 3 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Presenilin PF01080.17 CDI83944.1 - 3.7 6.2 6.2 17 4.0 0.0 2.2 2 0 0 2 2 2 0 Presenilin PEHE PF15275.6 CDI83944.1 - 4.7 7.9 9.5 12 6.6 1.7 2.7 3 0 0 3 3 2 0 PEHE domain TPR_2 PF07719.17 CDI83946.1 - 2.5e-17 61.5 16.9 5.5e-06 26.1 0.1 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDI83946.1 - 2.1e-14 52.6 6.4 3.5e-05 23.4 0.2 4.8 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDI83946.1 - 7.4e-10 38.3 0.2 0.0074 16.4 0.0 4.6 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI83946.1 - 6.7e-09 36.3 23.5 4.2e-05 24.1 1.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDI83946.1 - 1.2e-08 35.1 11.7 0.002 18.4 1.0 4.7 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDI83946.1 - 1.4e-08 34.9 23.7 0.019 15.7 0.3 6.1 3 1 4 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDI83946.1 - 9.4e-07 29.2 26.3 0.0059 17.1 3.1 4.7 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDI83946.1 - 6.1e-06 25.9 5.4 0.071 13.2 0.0 4.5 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDI83946.1 - 1.1e-05 24.8 3.6 1.1e-05 24.8 3.6 1.9 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI83946.1 - 4.2e-05 23.2 4.6 0.0043 16.7 1.7 3.8 4 1 0 4 4 4 1 TPR repeat ANAPC3 PF12895.7 CDI83946.1 - 0.00028 21.1 8.9 0.42 10.9 2.0 3.4 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDI83946.1 - 0.002 18.4 8.1 0.39 11.2 0.1 5.0 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 CDI83946.1 - 0.0044 16.8 1.3 2 8.1 2.5 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 CDI83946.1 - 0.021 15.4 10.3 6.2 7.7 0.1 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 CDI83946.1 - 0.022 14.7 1.9 0.76 9.8 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDI83946.1 - 0.07 13.0 0.4 0.07 13.0 0.4 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CDI83946.1 - 0.56 10.1 5.2 0.32 10.9 0.4 2.4 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TPR_9 PF13371.6 CDI83946.1 - 1.5 9.0 19.0 0.14 12.3 1.3 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.17 CDI83946.1 - 4.2 7.8 15.4 0.59 10.5 3.3 3.7 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TMEM51 PF15345.6 CDI83947.1 - 5 6.9 15.7 4.8 7.0 15.7 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 EIIBC-GUT_N PF03612.14 CDI83947.1 - 5.3 6.8 10.4 5 6.8 10.4 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CRF1 PF10380.9 CDI83947.1 - 5.5 7.4 8.8 5.9 7.3 8.8 1.0 1 0 0 1 1 1 0 Transcription factor CRF1 DUF4834 PF16118.5 CDI83947.1 - 7 7.7 15.4 7.3 7.6 15.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF775 PF05603.12 CDI83947.1 - 8.7 5.8 14.5 8.4 5.9 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Methyltrn_RNA_3 PF02598.17 CDI83948.1 - 1e-28 100.7 0.0 3.8e-18 66.0 0.0 2.2 2 0 0 2 2 2 2 Putative RNA methyltransferase DUF3915 PF13054.6 CDI83948.1 - 0.076 13.0 0.1 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) AdoHcyase PF05221.17 CDI83949.1 - 5e-97 324.7 0.3 1.5e-79 267.3 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase Collagen PF01391.18 CDI83950.1 - 9.6e-05 22.1 19.8 0.00025 20.7 19.8 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) CAP PF00188.26 CDI83952.1 - 1.5e-10 42.0 0.1 2.9e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TSP_1 PF00090.19 CDI83952.1 - 0.00014 22.0 7.1 0.00014 22.0 7.1 2.3 2 0 0 2 2 2 1 Thrombospondin type 1 domain CLTH PF10607.9 CDI83953.1 - 0.1 12.5 0.2 0.17 11.8 0.2 1.3 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DUF4051 PF13260.6 CDI83953.1 - 0.23 11.2 0.8 0.83 9.4 0.8 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) AAA_23 PF13476.6 CDI83953.1 - 0.33 11.4 4.4 5.2 7.5 0.2 2.2 2 0 0 2 2 2 0 AAA domain SUIM_assoc PF16619.5 CDI83953.1 - 7.1 6.8 12.4 0.99 9.5 6.0 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 p25-alpha PF05517.12 CDI83954.1 - 4e-37 127.8 2.7 4.5e-37 127.6 2.7 1.0 1 0 0 1 1 1 1 p25-alpha Toprim_C_rpt PF13368.6 CDI83954.1 - 0.084 12.9 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat SET PF00856.28 CDI83955.1 - 2e-11 44.6 0.0 1.5e-10 41.8 0.0 2.4 1 1 0 1 1 1 1 SET domain Ribo_biogen_C PF04034.13 CDI83956.1 - 1e-37 128.7 0.0 2e-37 127.7 0.0 1.5 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CDI83956.1 - 0.002 17.9 0.1 0.0038 17.0 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Sporozoite_P67 PF05642.11 CDI83957.1 - 3.4 5.6 14.6 3.9 5.4 14.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ashwin PF15323.6 CDI83957.1 - 3.6 7.5 15.5 5.7 6.9 15.5 1.3 1 0 0 1 1 1 0 Developmental protein Apt1 PF10351.9 CDI83957.1 - 9.3 5.0 14.6 11 4.7 14.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SusD_RagB PF07980.11 CDI83958.1 - 0.26 10.9 3.1 0.8 9.3 3.1 1.8 1 0 0 1 1 1 0 SusD family Zip PF02535.22 CDI83961.1 - 2.9 7.0 8.5 2.6 7.2 8.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 CDI83961.1 - 6.5 5.4 5.3 8.6 5.0 5.3 1.1 1 0 0 1 1 1 0 Ureide permease Pex14_N PF04695.13 CDI83962.1 - 0.0098 16.6 3.0 0.0098 16.6 3.0 5.0 3 1 1 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Coilin_N PF15862.5 CDI83962.1 - 0.01 15.6 1.1 0.01 15.6 1.1 3.9 4 0 0 4 4 4 0 Coilin N-terminus DnaJ PF00226.31 CDI83962.1 - 0.021 14.9 0.2 0.021 14.9 0.2 2.7 3 0 0 3 3 3 0 DnaJ domain CPSF100_C PF13299.6 CDI83962.1 - 0.7 10.1 25.3 0.055 13.7 3.4 4.2 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal LptF_LptG PF03739.14 CDI83962.1 - 1.1 8.0 5.1 6.3 5.5 0.6 2.7 3 1 0 3 3 3 0 Lipopolysaccharide export system permease LptF/LptG AAA PF00004.29 CDI83963.1 - 1.3e-05 25.6 8.4 0.029 14.8 0.0 5.3 4 2 1 5 5 5 2 ATPase family associated with various cellular activities (AAA) RskA PF10099.9 CDI83963.1 - 0.0067 16.7 14.8 0.0067 16.7 14.8 7.1 3 3 3 6 6 6 1 Anti-sigma-K factor rskA Clr2 PF10383.9 CDI83963.1 - 4.8 7.9 14.0 0.82 10.4 2.0 4.0 4 0 0 4 4 4 0 Transcription-silencing protein Clr2 zf-HC5HC2H_2 PF13832.6 CDI83964.1 - 2.5e-12 47.0 13.7 4.8e-07 29.9 0.1 3.3 3 0 0 3 3 3 2 PHD-zinc-finger like domain PHD_2 PF13831.6 CDI83964.1 - 1.7e-11 43.5 1.8 1.7e-11 43.5 1.8 3.5 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 CDI83964.1 - 6.5e-10 38.7 4.7 6.5e-10 38.7 4.7 3.2 3 1 0 3 3 3 1 PHD-finger zf-HC5HC2H PF13771.6 CDI83964.1 - 1.5e-06 28.4 14.7 9.2e-05 22.6 3.9 4.2 4 0 0 4 4 4 1 PHD-like zinc-binding domain C1_1 PF00130.22 CDI83964.1 - 0.00047 20.0 0.1 0.00047 20.0 0.1 3.1 4 0 0 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CDI83964.1 - 0.0019 18.5 0.8 0.0019 18.5 0.8 3.1 3 0 0 3 3 3 1 C1 domain Apt1 PF10351.9 CDI83964.1 - 0.0052 15.7 0.4 0.0052 15.7 0.4 2.1 2 0 0 2 2 2 1 Golgi-body localisation protein domain Prok-RING_1 PF14446.6 CDI83964.1 - 0.0094 15.9 2.1 0.034 14.1 2.1 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 cNMPbd_u2 PF16643.5 CDI83964.1 - 1.7 9.1 0.0 1.7 9.1 0.0 3.3 4 0 0 4 4 4 0 Unstructured region on cNMP-binding protein Secretin_N_2 PF07655.13 CDI83964.1 - 2.7 8.6 39.1 0.32 11.6 4.2 4.1 3 1 0 3 3 3 0 Secretin N-terminal domain hDGE_amylase PF14701.6 CDI83965.1 - 9.5e-114 380.9 0.0 3.6e-62 210.9 0.0 3.1 1 1 1 3 3 3 3 Glycogen debranching enzyme, glucanotransferase domain hGDE_central PF14702.6 CDI83965.1 - 5.7e-33 114.7 0.0 1.6e-32 113.2 0.0 1.8 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme GDE_C PF06202.14 CDI83965.1 - 8.4e-08 31.5 0.0 1.3e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase SUIM_assoc PF16619.5 CDI83965.1 - 0.022 14.8 0.4 0.022 14.8 0.4 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF473 PF04322.12 CDI83965.1 - 0.025 14.4 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF473) Alpha-amylase PF00128.24 CDI83965.1 - 0.22 11.1 0.0 6.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Alpha amylase, catalytic domain Spt20 PF12090.8 CDI83965.1 - 3.8 7.1 7.7 7 6.2 7.7 1.3 1 0 0 1 1 1 0 Spt20 family DUF2228 PF10228.9 CDI83966.1 - 4.4e-23 82.3 2.4 1.9e-20 73.7 0.0 3.7 4 0 0 4 4 4 2 Uncharacterised conserved protein (DUF2228) DUF2052 PF09747.9 CDI83966.1 - 0.026 14.7 15.7 0.065 13.4 7.5 2.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Connexin PF00029.19 CDI83966.1 - 0.31 10.8 7.1 0.2 11.4 1.5 2.4 2 0 0 2 2 2 0 Connexin DUF3546 PF12066.8 CDI83967.1 - 3.6e-09 36.8 0.6 5.8e-09 36.1 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) NARP1 PF12569.8 CDI83968.1 - 2.4e-14 53.2 3.2 5.6e-13 48.7 0.2 2.2 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 LCCL PF03815.19 CDI83968.1 - 3.6e-13 49.4 3.5 4.8e-13 49.0 0.1 2.7 3 0 0 3 3 3 1 LCCL domain F5_F8_type_C PF00754.25 CDI83968.1 - 1.4e-11 44.6 0.0 2.7e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain TPR_2 PF07719.17 CDI83968.1 - 1.1e-08 34.5 9.3 1.6e-05 24.7 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDI83968.1 - 6.8e-08 33.0 0.0 0.0019 18.8 0.4 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDI83968.1 - 1.3e-06 27.9 1.9 0.00016 21.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI83968.1 - 1.8e-06 27.7 2.0 0.0016 18.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI83968.1 - 7.3e-05 22.9 1.6 0.95 10.0 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDI83968.1 - 0.00017 21.8 2.1 0.13 12.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDI83968.1 - 0.0011 19.5 8.5 0.77 10.7 0.2 5.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI83968.1 - 0.0018 18.8 5.9 0.036 14.6 0.7 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDI83968.1 - 0.0075 16.2 0.5 0.15 12.2 0.1 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI83968.1 - 0.016 14.9 0.5 0.046 13.4 0.1 2.0 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.6 CDI83968.1 - 0.018 15.7 1.9 27 5.7 0.0 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDI83968.1 - 0.023 14.8 2.0 0.91 9.7 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1080 PF06439.11 CDI83968.1 - 0.09 12.9 0.0 0.33 11.0 0.0 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1080) ATG16 PF08614.11 CDI83968.1 - 0.85 9.8 5.8 0.19 11.9 0.7 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MscS_porin PF12795.7 CDI83968.1 - 4.5 6.8 9.0 0.46 10.0 2.2 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain RNA_pol_3_Rpc31 PF11705.8 CDI83969.1 - 4.9e-09 36.8 9.8 9.8e-08 32.5 9.8 2.2 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.10 CDI83969.1 - 0.003 18.2 5.0 0.0058 17.3 5.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) DUF4820 PF16091.5 CDI83969.1 - 0.056 12.8 2.0 0.075 12.4 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) LRR19-TM PF15176.6 CDI83969.1 - 3.8 7.6 6.0 6.8 6.7 6.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain IF-2B PF01008.17 CDI83970.1 - 1.1e-09 37.9 2.7 2.4e-09 36.8 2.7 1.5 1 0 0 1 1 1 1 Initiation factor 2 subunit family Coilin_N PF15862.5 CDI83970.1 - 0.015 15.1 0.8 0.015 15.1 0.8 2.8 1 1 1 2 2 2 0 Coilin N-terminus TFIIA PF03153.13 CDI83970.1 - 0.046 13.7 28.3 0.074 13.0 28.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 CDI83970.1 - 1.2 8.4 27.4 2.4 7.4 27.4 1.4 1 0 0 1 1 1 0 BUD22 MAP65_ASE1 PF03999.12 CDI83970.1 - 1.9 7.1 35.1 2.9 6.5 35.1 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SWI-SNF_Ssr4 PF08549.10 CDI83970.1 - 7.3 5.1 22.5 11 4.5 22.5 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Utp14 PF04615.13 CDI83970.1 - 7.9 4.9 21.8 14 4.1 21.8 1.3 1 0 0 1 1 1 0 Utp14 protein SUIM_assoc PF16619.5 CDI83971.1 - 0.31 11.2 16.2 0.032 14.3 2.6 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 EIF4E-T PF10477.9 CDI83971.1 - 0.39 9.5 3.8 0.53 9.1 3.8 1.3 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E NopRA1 PF16201.5 CDI83971.1 - 0.43 10.1 9.8 0.039 13.5 2.9 2.5 2 1 0 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 Pkinase PF00069.25 CDI83972.1 - 3.2e-24 85.7 0.5 2.7e-12 46.6 0.1 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI83972.1 - 1.2e-11 44.4 0.1 0.00013 21.3 0.1 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Spt20 PF12090.8 CDI83972.1 - 0.32 10.6 33.9 0.18 11.4 9.3 3.3 3 0 0 3 3 3 0 Spt20 family Mcm10 PF09332.11 CDI83974.1 - 1.4e-14 54.3 15.3 1.4e-14 54.3 15.3 3.1 2 1 1 3 3 3 1 Mcm10 replication factor zf-primase PF09329.11 CDI83974.1 - 3e-09 36.6 0.3 6.9e-09 35.4 0.3 1.6 1 0 0 1 1 1 1 Primase zinc finger DAPG_hydrolase PF18089.1 CDI83974.1 - 0.059 12.9 0.4 0.17 11.4 0.4 1.7 1 0 0 1 1 1 0 DAPG hydrolase PhiG domain DUF1967 PF09269.11 CDI83974.1 - 0.16 11.9 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) DZR PF12773.7 CDI83974.1 - 4.7 7.3 7.9 82 3.3 7.9 2.7 1 1 0 1 1 1 0 Double zinc ribbon Ndc80_HEC PF03801.13 CDI83975.1 - 1.2e-23 83.4 0.0 1.2e-23 83.4 0.0 3.2 3 1 1 4 4 4 1 HEC/Ndc80p family RasGAP_C PF03836.15 CDI83975.1 - 0.68 10.1 0.0 0.68 10.1 0.0 4.4 2 2 1 3 3 3 0 RasGAP C-terminus Serglycin PF04360.12 CDI83978.1 - 0.0073 16.3 4.0 0.0073 16.3 4.0 8.2 5 2 1 6 6 6 1 Serglycin PROCN PF08083.11 CDI83980.1 - 8.1e-231 765.8 6.3 1.3e-230 765.2 6.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CDI83980.1 - 4.6e-124 412.5 1.3 7.6e-124 411.8 1.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CDI83980.1 - 4e-88 293.4 2.3 8.2e-88 292.3 2.3 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CDI83980.1 - 5.7e-83 276.4 0.9 1.3e-82 275.2 0.9 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CDI83980.1 - 4.8e-71 237.1 0.0 9.5e-71 236.1 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 CDI83980.1 - 1.2e-49 167.3 0.0 2.6e-49 166.2 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 CDI83980.1 - 3.1e-46 155.6 0.2 9.3e-46 154.1 0.2 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 CDI83980.1 - 0.098 12.6 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease zf-CW PF07496.15 CDI83983.1 - 1.1e-16 60.6 5.0 2.8e-16 59.3 5.0 1.8 1 0 0 1 1 1 1 CW-type Zinc Finger ANAPC4_WD40 PF12894.7 CDI83983.1 - 0.00014 22.1 0.0 0.33 11.3 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SR-25 PF10500.9 CDI83983.1 - 0.0011 18.6 9.3 0.0011 18.6 9.3 16.0 13 4 4 17 17 17 4 Nuclear RNA-splicing-associated protein SDA1 PF05285.12 CDI83983.1 - 0.25 10.7 0.0 0.25 10.7 0.0 11.6 6 2 5 11 11 11 0 SDA1 Adaptin_binding PF10199.9 CDI83983.1 - 0.84 10.3 0.0 0.84 10.3 0.0 13.5 6 5 1 7 7 7 0 Alpha and gamma adaptin binding protein p34 Spt20 PF12090.8 CDI83984.1 - 0.0003 20.5 21.6 0.0057 16.3 1.3 2.5 2 0 0 2 2 2 2 Spt20 family RskA PF10099.9 CDI83984.1 - 0.0032 17.8 2.3 0.0032 17.8 2.3 3.9 2 1 1 3 3 3 1 Anti-sigma-K factor rskA Roughex PF06020.11 CDI83984.1 - 0.1 11.7 19.5 0.39 9.8 1.2 2.2 2 0 0 2 2 2 0 Drosophila roughex protein DUF2722 PF10846.8 CDI83984.1 - 0.2 10.6 21.9 0.08 11.9 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF908 PF06012.12 CDI83984.1 - 2.6 7.4 11.3 5.7 6.3 2.4 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) ANAPC_CDC26 PF10471.9 CDI83984.1 - 7.3 7.5 33.7 2.2 9.2 7.2 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 DUF719 PF05334.13 CDI83984.1 - 8 6.6 13.4 2.1 8.5 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF719) DUF4746 PF15928.5 CDI83984.1 - 8.9 5.6 11.4 14 5.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) MPC PF03650.13 CDI83985.1 - 1.9e-31 108.4 0.2 3.6e-31 107.6 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Hid1 PF12722.7 CDI83985.1 - 0.52 8.4 13.2 0.84 7.7 13.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LSM PF01423.22 CDI83986.1 - 1.2e-18 66.6 0.1 1.5e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Pkinase PF00069.25 CDI83987.1 - 1.2e-35 123.2 0.0 9.9e-24 84.1 0.0 4.6 4 1 1 5 5 5 2 Protein kinase domain SR-25 PF10500.9 CDI83987.1 - 0.0041 16.8 9.9 0.0041 16.8 9.9 9.0 6 1 3 9 9 9 2 Nuclear RNA-splicing-associated protein Glycolytic PF00274.19 CDI83988.1 - 2.5e-168 559.3 0.0 2.8e-168 559.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Rad10 PF03834.14 CDI83989.1 - 1.5e-11 44.4 0.1 3e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) DUF2722 PF10846.8 CDI83989.1 - 5.4e-05 22.3 8.8 6.6e-05 22.0 8.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) HHH PF00633.23 CDI83989.1 - 0.0006 19.5 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Sin_N PF04801.13 CDI83989.1 - 0.021 14.0 10.4 0.037 13.2 10.4 1.4 1 0 0 1 1 1 0 Sin-like protein conserved region HHH_2 PF12826.7 CDI83989.1 - 0.033 14.3 0.0 0.09 12.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Pex14_N PF04695.13 CDI83989.1 - 0.13 12.9 15.5 0.055 14.1 11.4 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TUSC2 PF15000.6 CDI83989.1 - 0.31 11.3 4.2 0.91 9.8 4.2 1.7 1 0 0 1 1 1 0 Tumour suppressor candidate 2 Spt20 PF12090.8 CDI83989.1 - 0.64 9.6 33.0 0.87 9.2 29.5 2.5 3 0 0 3 3 3 0 Spt20 family Ndc1_Nup PF09531.10 CDI83989.1 - 0.67 8.6 6.0 0.69 8.5 6.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BAT2_N PF07001.11 CDI83989.1 - 0.95 9.9 15.1 0.066 13.7 8.5 2.1 2 0 0 2 2 2 0 BAT2 N-terminus XRN_N PF03159.18 CDI83989.1 - 1.2 8.5 6.7 2 7.8 6.7 1.3 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus CLN3 PF02487.17 CDI83989.1 - 1.9 7.5 4.1 2.9 6.9 4.1 1.3 1 0 0 1 1 1 0 CLN3 protein OATP PF03137.20 CDI83989.1 - 1.9 6.7 3.4 2.8 6.1 3.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EPL1 PF10513.9 CDI83989.1 - 2.2 8.6 9.8 0.22 11.9 5.5 1.6 2 0 0 2 2 2 0 Enhancer of polycomb-like TERB2 PF15101.6 CDI83989.1 - 2.2 8.3 12.1 4.6 7.2 12.1 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 eIF-3_zeta PF05091.12 CDI83989.1 - 3.2 6.6 11.4 4.7 6.1 11.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 CDI83989.1 - 4.1 7.6 9.8 2.8 8.1 6.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PAT1 PF09770.9 CDI83989.1 - 4.1 5.6 21.7 5.4 5.2 21.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3371 PF11851.8 CDI83989.1 - 4.5 8.4 14.1 57 4.8 11.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3371) Connexin PF00029.19 CDI83989.1 - 6.8 6.4 5.9 13 5.4 5.9 1.5 1 0 0 1 1 1 0 Connexin UPF0560 PF10577.9 CDI83989.1 - 9.9 4.5 14.0 13 4.1 14.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Thioredoxin PF00085.20 CDI83990.1 - 3.6e-05 23.7 0.0 5.3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 CDI83990.1 - 0.0024 17.8 0.0 0.0033 17.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain PIG-U PF06728.13 CDI83990.1 - 0.028 13.5 0.0 0.036 13.1 0.0 1.1 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U ketoacyl-synt PF00109.26 CDI83992.1 - 4.6e-79 265.6 0.4 4.6e-79 265.6 0.4 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 CDI83992.1 - 1.4e-73 247.9 0.0 5.9e-73 245.9 0.0 2.1 2 1 0 2 2 2 1 AMP-binding enzyme PS-DH PF14765.6 CDI83992.1 - 2.5e-41 141.9 0.0 7.8e-31 107.4 0.0 2.3 2 0 0 2 2 2 2 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CDI83992.1 - 9e-41 138.6 0.0 2.3e-40 137.3 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CDI83992.1 - 3.7e-21 75.9 0.0 6.6e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ADH_zinc_N PF00107.26 CDI83992.1 - 5.5e-12 45.8 0.0 1.4e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.25 CDI83992.1 - 2.5e-11 43.8 0.3 8.4e-11 42.1 0.3 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDI83992.1 - 4.6e-09 36.7 0.0 1.5e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 CDI83992.1 - 3.2e-08 34.7 0.0 2.4e-07 31.9 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDI83992.1 - 2.3e-06 27.5 1.1 8.2e-06 25.7 0.1 2.4 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 CDI83992.1 - 4.8e-05 22.9 1.3 8.5e-05 22.0 0.1 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain AMP-binding_C_2 PF14535.6 CDI83992.1 - 0.0051 17.1 0.0 0.015 15.6 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACP_syn_III PF08545.10 CDI83992.1 - 0.049 13.5 0.8 0.14 12.0 0.3 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III TRAPPC-Trs85 PF12739.7 CDI83996.1 - 2.6e-50 171.6 19.9 2.6e-50 171.6 19.9 4.6 1 1 1 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit LRR_4 PF12799.7 CDI83997.1 - 5.8e-12 45.6 16.5 0.00023 21.4 1.6 4.5 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDI83997.1 - 1.5e-10 40.7 17.8 4.6e-06 26.3 4.6 3.8 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 CDI83997.1 - 2.2e-05 24.1 13.0 6.3 7.1 0.1 5.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 CDI83997.1 - 0.01 16.3 10.1 0.23 12.1 0.2 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.6 CDI83997.1 - 0.014 14.9 4.1 0.29 10.6 0.7 2.6 1 1 1 2 2 2 0 Leucine-rich repeat DUF2805 PF10985.8 CDI83997.1 - 0.42 11.0 2.9 0.98 9.8 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) Peptidase_C54 PF03416.19 CDI83998.1 - 2.8e-17 63.1 29.0 1.1e-13 51.3 0.2 5.0 4 0 0 4 4 4 3 Peptidase family C54 MFMR_assoc PF16596.5 CDI83999.1 - 0.029 14.8 1.5 0.029 14.8 1.5 2.6 4 0 0 4 4 4 0 Disordered region downstream of MFMR Phytase-like PF13449.6 CDI83999.1 - 0.77 9.6 4.1 0.14 12.1 0.4 1.6 2 0 0 2 2 2 0 Esterase-like activity of phytase DDHD PF02862.17 CDI84001.1 - 0.012 15.7 2.7 0.91 9.6 0.3 2.2 2 0 0 2 2 2 0 DDHD domain AAA_23 PF13476.6 CDI84001.1 - 0.16 12.5 8.3 0.96 9.9 0.2 2.2 2 0 0 2 2 2 0 AAA domain OATP PF03137.20 CDI84001.1 - 0.37 9.0 3.8 1.2 7.3 0.1 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2076 PF09849.9 CDI84001.1 - 0.39 10.7 22.2 0.32 11.0 16.1 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) EPL1 PF10513.9 CDI84001.1 - 0.49 10.8 8.3 0.73 10.2 0.7 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like TFIIA PF03153.13 CDI84001.1 - 0.51 10.3 23.8 0.68 9.9 17.8 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 CDI84001.1 - 1.7 8.4 10.3 0.89 9.3 0.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 CDI84001.1 - 5.4 7.0 7.7 15 5.5 0.3 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BRF1 PF07741.13 CDI84001.1 - 5.9 7.3 17.2 13 6.2 3.0 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Pan3_PK PF18101.1 CDI84003.1 - 1.8e-37 128.4 0.0 2.9e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain MSA-2c PF12238.8 CDI84003.1 - 5.7 6.9 9.5 1.2 9.1 0.8 2.3 2 0 0 2 2 2 0 Merozoite surface antigen 2c Imm5 PF14423.6 CDI84004.1 - 0.26 11.5 1.4 0.91 9.7 1.4 1.9 1 0 0 1 1 1 0 Immunity protein Imm5 DUF2722 PF10846.8 CDI84007.1 - 0.00028 20.0 4.4 0.00034 19.7 4.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Acetyltransf_10 PF13673.7 CDI84007.1 - 0.0024 17.8 3.6 0.0047 16.9 3.6 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDI84007.1 - 0.011 16.1 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDI84007.1 - 0.018 15.0 0.1 0.046 13.7 0.1 1.7 1 0 0 1 1 1 0 FR47-like protein SpoIIP PF07454.11 CDI84007.1 - 0.031 13.7 1.0 0.042 13.3 1.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) XRN_N PF03159.18 CDI84007.1 - 0.071 12.5 4.1 0.092 12.2 4.1 1.3 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus eIF-3_zeta PF05091.12 CDI84007.1 - 0.16 10.9 5.9 0.21 10.5 5.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 CDI84007.1 - 0.22 10.2 9.6 0.32 9.7 9.6 1.4 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CDI84007.1 - 0.22 10.4 1.5 0.38 9.7 1.5 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 CDI84007.1 - 0.29 10.9 1.3 0.45 10.2 1.3 1.3 1 0 0 1 1 1 0 Connexin DNApol_Exo PF18136.1 CDI84007.1 - 0.33 10.0 3.6 0.63 9.1 3.6 1.4 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Suf PF05843.14 CDI84007.1 - 0.53 10.2 12.6 1 9.3 12.6 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RR_TM4-6 PF06459.12 CDI84007.1 - 1 9.1 10.5 2.2 8.1 10.5 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 CDI84007.1 - 1.1 7.4 14.2 1.6 6.9 14.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TERB2 PF15101.6 CDI84007.1 - 1.1 9.2 7.7 2.2 8.3 7.7 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 V_ATPase_I PF01496.19 CDI84007.1 - 1.2 7.0 3.4 1.5 6.6 3.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rrn6 PF10214.9 CDI84007.1 - 1.7 7.1 15.6 2.3 6.6 15.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Sec62 PF03839.16 CDI84007.1 - 1.7 8.1 4.3 3.1 7.2 4.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Apc15p PF05841.11 CDI84007.1 - 2.5 8.9 17.5 0.17 12.7 11.5 2.2 2 1 0 2 2 1 0 Apc15p protein Roughex PF06020.11 CDI84007.1 - 2.7 7.0 14.5 5.1 6.1 14.5 1.5 1 0 0 1 1 1 0 Drosophila roughex protein DUF572 PF04502.13 CDI84007.1 - 2.7 7.5 14.1 1.8 8.1 10.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF572) XRCC4 PF06632.12 CDI84007.1 - 3.5 6.4 11.7 6.3 5.5 11.7 1.4 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Eapp_C PF10238.9 CDI84007.1 - 4.7 7.3 13.8 0.54 10.3 8.9 2.0 2 0 0 2 2 1 0 E2F-associated phosphoprotein DUF2058 PF09831.9 CDI84007.1 - 9.1 6.4 22.9 0.53 10.4 15.9 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) SOBP PF15279.6 CDI84007.1 - 9.6 6.7 11.6 2.8 8.5 8.7 1.5 2 0 0 2 2 2 0 Sine oculis-binding protein ATP-synt_C PF00137.21 CDI84008.1 - 6.3e-31 106.5 33.2 3.3e-19 69.0 14.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Mtc PF03820.17 CDI84009.1 - 2.6e-16 59.6 6.3 2.6e-16 59.6 6.3 1.5 1 1 0 1 1 1 1 Tricarboxylate carrier DUF3685 PF12452.8 CDI84009.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) DUF1772 PF08592.11 CDI84010.1 - 0.89 9.9 2.7 1.9 8.8 2.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) AhpC-TSA PF00578.21 CDI84011.1 - 1.4e-36 125.1 0.0 1.8e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDI84011.1 - 4.8e-17 62.0 0.0 5.9e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDI84011.1 - 1.4e-13 50.4 0.1 2.9e-13 49.4 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 CDI84011.1 - 0.07 13.1 0.1 0.2 11.6 0.1 1.7 2 0 0 2 2 2 0 SCO1/SenC DUF4200 PF13863.6 CDI84012.1 - 3.6e-24 85.4 12.5 3.6e-24 85.4 12.5 3.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4200) Orbi_VP5 PF00901.17 CDI84012.1 - 0.003 16.0 4.1 0.003 16.0 4.1 1.7 2 0 0 2 2 2 1 Orbivirus outer capsid protein VP5 OmpH PF03938.14 CDI84012.1 - 0.0065 16.8 46.7 0.29 11.5 6.3 3.4 3 0 0 3 3 3 3 Outer membrane protein (OmpH-like) Prefoldin_2 PF01920.20 CDI84012.1 - 0.022 14.7 3.1 0.022 14.7 3.1 5.1 3 1 2 5 5 5 0 Prefoldin subunit Baculo_PEP_C PF04513.12 CDI84012.1 - 1.4 8.9 5.2 17 5.4 0.3 2.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RYDR_ITPR PF01365.21 CDI84014.1 - 0.03 13.7 0.0 0.034 13.6 0.0 1.0 1 0 0 1 1 1 0 RIH domain PADR1 PF08063.12 CDI84015.1 - 0.6 9.9 2.8 1.1 9.0 0.2 2.7 3 0 0 3 3 3 0 PADR1 (NUC008) domain Adap_comp_sub PF00928.21 CDI84016.1 - 0.00033 20.1 0.1 0.00042 19.8 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Serglycin PF04360.12 CDI84016.1 - 0.11 12.4 0.3 0.2 11.6 0.3 1.4 1 0 0 1 1 1 0 Serglycin XPC-binding PF09280.11 CDI84016.1 - 8.9 6.1 12.0 0.32 10.8 0.9 2.9 3 0 0 3 3 3 0 XPC-binding domain AAA PF00004.29 CDI84018.1 - 4.3e-45 153.4 0.1 2e-44 151.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDI84018.1 - 3.6e-10 39.5 0.1 7.4e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDI84018.1 - 9.4e-09 35.4 0.2 2.7e-08 33.9 0.2 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDI84018.1 - 2e-08 34.5 0.0 3.6e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDI84018.1 - 3.5e-06 27.5 1.7 0.00063 20.2 0.0 2.5 2 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 CDI84018.1 - 5.2e-06 26.8 0.5 0.002 18.4 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 CDI84018.1 - 1.5e-05 24.8 0.0 4.6e-05 23.2 0.0 1.8 2 1 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 CDI84018.1 - 3.8e-05 23.0 0.0 6.7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 CDI84018.1 - 0.00026 21.0 0.2 0.0044 16.9 0.0 2.3 3 0 0 3 3 2 1 NTPase AAA_18 PF13238.6 CDI84018.1 - 0.00028 21.4 0.0 0.00047 20.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDI84018.1 - 0.00028 21.2 0.0 0.00058 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CDI84018.1 - 0.00038 20.8 0.0 0.00091 19.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 CDI84018.1 - 0.00041 19.6 0.1 0.0073 15.5 0.0 2.4 2 1 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 CDI84018.1 - 0.0009 18.7 0.0 0.0021 17.5 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDI84018.1 - 0.00098 19.3 0.3 0.0052 16.9 0.1 2.1 2 1 1 3 3 3 1 AAA domain AAA_7 PF12775.7 CDI84018.1 - 0.0015 18.1 0.1 0.012 15.1 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDI84018.1 - 0.0021 17.8 0.0 0.0049 16.6 0.0 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein TsaE PF02367.17 CDI84018.1 - 0.0025 17.8 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 CDI84018.1 - 0.0033 17.3 0.0 0.019 14.9 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CDI84018.1 - 0.0037 17.2 0.1 0.068 13.1 0.0 2.2 1 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CDI84018.1 - 0.0047 16.7 0.1 0.0099 15.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDI84018.1 - 0.0061 16.1 0.7 0.073 12.6 0.1 2.2 1 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CDI84018.1 - 0.0068 16.1 0.3 0.044 13.5 0.0 2.2 2 1 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 CDI84018.1 - 0.0084 16.0 0.1 0.068 13.1 0.0 2.2 2 0 0 2 2 2 1 NACHT domain ATPase PF06745.13 CDI84018.1 - 0.0097 15.3 0.2 0.35 10.2 0.0 2.2 2 0 0 2 2 2 1 KaiC Parvo_NS1 PF01057.17 CDI84018.1 - 0.014 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TniB PF05621.11 CDI84018.1 - 0.015 14.7 0.1 1.1 8.7 0.0 2.2 1 1 0 2 2 2 0 Bacterial TniB protein AAA_14 PF13173.6 CDI84018.1 - 0.016 15.2 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDI84018.1 - 0.017 14.8 0.3 0.049 13.3 0.3 1.9 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDI84018.1 - 0.019 14.1 0.0 0.18 11.0 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.27 CDI84018.1 - 0.025 15.1 0.0 0.08 13.5 0.0 2.0 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 CDI84018.1 - 0.029 13.6 0.0 0.068 12.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Torsin PF06309.11 CDI84018.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Torsin PhoH PF02562.16 CDI84018.1 - 0.08 12.4 0.1 0.19 11.1 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein cobW PF02492.19 CDI84018.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 CDI84018.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CDI84018.1 - 0.16 11.7 0.1 0.25 11.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 CDI84018.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain FAM60A PF15396.6 CDI84019.1 - 0.0032 17.5 1.8 0.0043 17.1 1.8 1.3 1 0 0 1 1 1 1 Protein Family FAM60A SPX PF03105.19 CDI84019.1 - 0.0033 17.4 7.2 0.0036 17.3 7.2 1.1 1 0 0 1 1 1 1 SPX domain Apt1 PF10351.9 CDI84019.1 - 0.0055 15.6 7.8 0.0067 15.3 7.8 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Spt20 PF12090.8 CDI84019.1 - 0.0075 15.9 22.9 0.014 15.1 22.9 1.3 1 0 0 1 1 1 1 Spt20 family SLC12 PF03522.15 CDI84019.1 - 0.0094 15.0 3.2 0.012 14.7 3.2 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Afi1 PF07792.12 CDI84019.1 - 0.0098 16.4 5.4 0.0098 16.4 5.4 1.6 2 0 0 2 2 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 CDI84019.1 - 0.014 14.2 6.9 0.018 13.9 6.9 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 CDI84019.1 - 0.016 14.1 6.5 0.022 13.5 6.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Mem_trans PF03547.18 CDI84019.1 - 0.027 12.9 0.3 0.026 13.0 0.3 1.1 1 0 0 1 1 1 0 Membrane transport protein Peptidase_S64 PF08192.11 CDI84019.1 - 0.033 12.7 7.5 0.039 12.4 7.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 SURF6 PF04935.12 CDI84019.1 - 0.033 14.0 10.6 0.048 13.5 10.6 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 Ndc1_Nup PF09531.10 CDI84019.1 - 0.047 12.4 6.0 0.054 12.2 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Menin PF05053.13 CDI84019.1 - 0.059 11.7 8.0 0.087 11.2 8.0 1.2 1 0 0 1 1 1 0 Menin CCDC106 PF15794.5 CDI84019.1 - 0.073 12.8 15.3 0.14 11.9 15.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SR-25 PF10500.9 CDI84019.1 - 0.079 12.6 26.3 0.048 13.3 24.1 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Smg8_Smg9 PF10220.9 CDI84019.1 - 0.095 11.0 6.6 0.11 10.7 6.6 1.1 1 0 0 1 1 1 0 Smg8_Smg9 XRN_M PF17846.1 CDI84019.1 - 0.13 11.2 1.4 0.19 10.6 1.4 1.4 1 0 0 1 1 1 0 Xrn1 helical domain Ctr PF04145.15 CDI84019.1 - 0.13 12.8 1.4 0.2 12.2 1.4 1.4 1 0 0 1 1 1 0 Ctr copper transporter family Connexin PF00029.19 CDI84019.1 - 0.2 11.4 3.2 0.37 10.5 3.2 1.3 1 0 0 1 1 1 0 Connexin Androgen_recep PF02166.16 CDI84019.1 - 0.2 10.4 13.4 0.31 9.9 13.4 1.2 1 0 0 1 1 1 0 Androgen receptor CPSF100_C PF13299.6 CDI84019.1 - 0.22 11.7 5.8 0.14 12.4 3.4 1.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal AF-4 PF05110.13 CDI84019.1 - 0.41 8.7 23.2 0.62 8.1 23.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4175 PF13779.6 CDI84019.1 - 0.44 8.4 10.2 0.55 8.1 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CDK2AP PF09806.9 CDI84019.1 - 0.45 10.5 14.9 0.88 9.6 14.9 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein GREB1 PF15782.5 CDI84019.1 - 0.48 7.5 11.7 0.66 7.0 11.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Roughex PF06020.11 CDI84019.1 - 0.62 9.1 5.7 0.95 8.5 5.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein SARAF PF06682.12 CDI84019.1 - 0.65 9.6 13.9 0.1 12.2 10.1 1.5 2 0 0 2 2 1 0 SOCE-associated regulatory factor of calcium homoeostasis Hid1 PF12722.7 CDI84019.1 - 0.7 7.9 9.1 0.9 7.6 9.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CDI84019.1 - 0.7 9.9 4.0 1 9.4 4.0 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Rrn6 PF10214.9 CDI84019.1 - 0.78 8.2 19.4 1.1 7.7 19.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF755 PF05501.11 CDI84019.1 - 0.85 9.9 36.8 0.053 13.8 31.1 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF755) Band_3_cyto PF07565.13 CDI84019.1 - 1.3 8.7 8.0 2.3 8.0 8.0 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Gti1_Pac2 PF09729.9 CDI84019.1 - 1.6 8.8 11.8 3.2 7.8 11.8 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family SID-1_RNA_chan PF13965.6 CDI84019.1 - 2 6.8 6.3 3 6.2 6.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PRC2_HTH_1 PF18118.1 CDI84019.1 - 2.3 9.1 8.5 1.1 10.2 5.8 1.7 2 0 0 2 2 1 0 Polycomb repressive complex 2 tri-helical domain Pap_E4 PF02711.14 CDI84019.1 - 2.7 9.0 8.1 1.2 10.2 5.5 1.7 2 0 0 2 2 1 0 E4 protein MPM1 PF17234.2 CDI84019.1 - 2.7 8.2 14.7 0.26 11.5 10.4 1.4 2 0 0 2 2 1 0 Mitochondrial peculiar membrane protein 1 CLN3 PF02487.17 CDI84019.1 - 3.3 6.7 6.2 6 5.8 6.2 1.3 1 0 0 1 1 1 0 CLN3 protein AIF_C PF14721.6 CDI84019.1 - 3.4 8.1 6.7 7.5 6.9 6.7 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF1635 PF07795.11 CDI84019.1 - 5 6.9 15.7 11 5.8 15.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Kei1 PF08552.11 CDI84019.1 - 5.3 6.9 6.4 9.3 6.1 6.4 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TERB2 PF15101.6 CDI84019.1 - 5.5 7.0 13.9 3.3 7.7 12.0 1.5 2 0 0 2 2 1 0 Telomere-associated protein TERB2 EBP50_C PF09007.11 CDI84019.1 - 6 7.9 16.5 2.7 9.0 14.0 1.6 2 0 0 2 2 1 0 EBP50, C-terminal V_ATPase_I PF01496.19 CDI84019.1 - 7.5 4.3 9.9 9.9 3.9 9.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NST1 PF13945.6 CDI84019.1 - 8.8 6.4 20.0 17 5.4 20.0 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator PRCC PF10253.9 CDI84020.1 - 1.1e-16 62.3 20.1 1.1e-16 62.3 20.1 4.3 2 2 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Tic22 PF04278.12 CDI84021.1 - 1.6e-07 30.9 0.0 0.0074 15.7 0.0 2.6 2 0 0 2 2 2 2 Tic22-like family TFIIA PF03153.13 CDI84021.1 - 0.0068 16.5 3.7 0.0068 16.5 3.7 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI84021.1 - 0.028 14.0 16.9 0.027 14.1 6.2 2.2 2 0 0 2 2 2 0 Spt20 family Pex26 PF07163.12 CDI84021.1 - 0.088 12.1 1.3 0.27 10.5 1.3 1.7 1 0 0 1 1 1 0 Pex26 protein DUF2722 PF10846.8 CDI84021.1 - 0.89 8.4 10.9 0.017 14.1 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Inj_translocase PF16928.5 CDI84021.1 - 3.7 7.0 15.4 1.3 8.5 7.6 2.6 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome ABC_tran_Xtn PF12848.7 CDI84021.1 - 5.1 7.2 14.4 0.94 9.6 7.3 2.4 2 0 0 2 2 2 0 ABC transporter Nuf2 PF03800.14 CDI84025.1 - 0.013 15.6 0.2 0.098 12.8 0.0 2.3 2 0 0 2 2 2 0 Nuf2 family SR-25 PF10500.9 CDI84025.1 - 9.5 5.7 18.7 0.27 10.8 10.1 2.4 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI84026.1 - 1.3 9.1 7.9 0.2 11.7 3.9 1.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 eRF1_1 PF03463.15 CDI84027.1 - 1.4e-34 118.9 0.0 2.2e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 CDI84027.1 - 3.1e-15 56.6 0.0 5.7e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CDI84027.1 - 4.8e-15 56.0 0.0 1.4e-14 54.5 0.0 1.8 1 0 0 1 1 1 1 eRF1 domain 3 MMACHC PF16690.5 CDI84027.1 - 0.12 12.0 0.2 0.19 11.3 0.2 1.2 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type C family IMUP PF15761.5 CDI84027.1 - 2.4 8.9 6.8 5 7.9 6.8 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein TFIIA PF03153.13 CDI84029.1 - 0.00025 21.2 17.8 0.00031 20.9 17.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI84029.1 - 0.058 13.4 14.1 0.077 13.0 14.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) XRN_N PF03159.18 CDI84029.1 - 0.062 12.7 5.5 0.088 12.2 5.5 1.3 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus NPR3 PF03666.13 CDI84029.1 - 0.068 12.0 8.8 0.078 11.8 8.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 CDI84029.1 - 0.073 13.1 8.1 0.095 12.7 8.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 CDI84029.1 - 0.084 13.0 11.8 0.15 12.1 11.8 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region SMYLE_N PF18615.1 CDI84029.1 - 0.088 12.4 10.1 0.13 11.8 10.1 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CCSAP PF15748.5 CDI84029.1 - 0.11 12.6 17.5 0.16 12.2 17.5 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PAT1 PF09770.9 CDI84029.1 - 0.14 10.5 17.3 0.15 10.3 17.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MecA PF05389.12 CDI84029.1 - 0.14 11.8 7.8 0.2 11.2 7.8 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) RR_TM4-6 PF06459.12 CDI84029.1 - 0.16 11.7 15.8 0.23 11.3 15.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 CDI84029.1 - 0.17 11.1 3.9 0.18 11.0 3.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CDI84029.1 - 0.18 9.9 9.6 0.19 9.9 9.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CDI84029.1 - 0.23 10.2 16.7 0.28 9.9 16.7 1.1 1 0 0 1 1 1 0 Presenilin Hydin_ADK PF17213.3 CDI84029.1 - 0.34 11.2 14.0 0.67 10.2 14.0 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Pex14_N PF04695.13 CDI84029.1 - 0.39 11.4 22.5 0.04 14.6 18.2 1.5 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM60A PF15396.6 CDI84029.1 - 0.45 10.5 9.3 0.61 10.0 9.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A GREB1 PF15782.5 CDI84029.1 - 0.65 7.0 11.2 0.74 6.9 11.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF-3_zeta PF05091.12 CDI84029.1 - 0.83 8.6 14.5 1 8.3 14.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Lin-8 PF03353.15 CDI84029.1 - 0.86 9.1 17.5 1.2 8.6 17.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ndc1_Nup PF09531.10 CDI84029.1 - 0.91 8.1 9.3 0.9 8.2 9.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SpoIIP PF07454.11 CDI84029.1 - 1.1 8.7 11.4 1.5 8.2 11.4 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 CDI84029.1 - 1.1 7.5 17.0 1.3 7.2 17.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DNApol_Exo PF18136.1 CDI84029.1 - 1.6 7.8 8.7 2.2 7.4 8.7 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Apt1 PF10351.9 CDI84029.1 - 1.9 7.2 12.1 2.3 7.0 12.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Band_3_cyto PF07565.13 CDI84029.1 - 2.3 7.9 9.8 3.4 7.4 9.8 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spore_coat_CotO PF14153.6 CDI84029.1 - 3.1 7.7 21.2 5.1 7.0 21.2 1.3 1 0 0 1 1 1 0 Spore coat protein CotO MDM31_MDM32 PF08118.11 CDI84029.1 - 4.1 6.0 6.3 5.6 5.5 6.3 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins FHIPEP PF00771.20 CDI84029.1 - 4.2 5.7 6.7 6.7 5.0 6.7 1.4 1 0 0 1 1 1 0 FHIPEP family Peptidase_S64 PF08192.11 CDI84029.1 - 5.1 5.4 10.2 5.8 5.3 10.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 OATP PF03137.20 CDI84029.1 - 8.5 4.5 6.1 11 4.1 6.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 CDI84029.1 - 8.5 5.1 8.3 11 4.8 8.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pribosyltran PF00156.27 CDI84030.1 - 3.4e-22 78.7 0.0 4.4e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 CDI84030.1 - 0.13 11.8 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase CTP_transf_like PF01467.26 CDI84031.1 - 1.1e-31 109.9 0.2 1.8e-31 109.2 0.2 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like SHE3 PF17078.5 CDI84032.1 - 0.024 14.4 18.3 0.15 11.7 3.1 2.3 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 ATG16 PF08614.11 CDI84032.1 - 0.097 12.9 43.8 0.36 11.0 7.3 3.9 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 CDI84032.1 - 0.15 12.2 0.1 0.15 12.2 0.1 3.4 2 2 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF812 PF05667.11 CDI84032.1 - 0.27 10.1 29.4 0.82 8.5 10.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Mod_r PF07200.13 CDI84032.1 - 0.43 10.7 23.7 0.95 9.6 1.1 3.4 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Lebercilin PF15619.6 CDI84032.1 - 0.54 9.9 35.4 0.22 11.1 16.5 3.3 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Atg14 PF10186.9 CDI84032.1 - 0.9 8.6 25.3 0.42 9.6 1.6 3.1 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 COG6 PF06419.11 CDI84032.1 - 1.2 7.2 16.8 0.45 8.7 1.9 2.4 2 1 0 2 2 2 0 Conserved oligomeric complex COG6 DUF677 PF05055.12 CDI84032.1 - 1.9 7.3 11.5 0.051 12.5 4.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF677) DUF948 PF06103.11 CDI84032.1 - 3.1 8.1 16.1 14 6.0 1.4 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) T2SSF PF00482.23 CDI84032.1 - 3.8 7.5 5.5 2.6 8.0 3.2 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Rootletin PF15035.6 CDI84032.1 - 4.7 7.2 28.5 0.038 14.0 1.9 3.4 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.6 CDI84032.1 - 6.7 6.5 35.4 3.4 7.4 9.5 3.3 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH KH_1 PF00013.29 CDI84033.1 - 5.9e-19 67.7 4.6 1.5e-07 31.2 0.0 6.4 6 0 0 6 6 6 5 KH domain BMC PF00936.19 CDI84033.1 - 0.0025 17.8 3.3 0.12 12.4 0.0 4.6 4 2 1 5 5 5 1 BMC domain KH_2 PF07650.17 CDI84033.1 - 0.2 11.5 8.8 4 7.3 0.0 4.0 4 0 0 4 4 4 0 KH domain MBF1 PF08523.10 CDI84033.1 - 3 8.4 9.4 14 6.2 1.9 4.1 2 0 0 2 2 2 0 Multiprotein bridging factor 1 PRA1 PF03208.19 CDI84034.1 - 3.8e-16 59.0 0.0 5.4e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 PRA1 family protein TFIIB PF00382.19 CDI84035.1 - 5.5e-11 42.4 0.2 5.5e-11 42.4 0.2 2.5 3 0 0 3 3 3 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CDI84035.1 - 2.6e-08 33.2 2.8 4.6e-08 32.4 2.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding BRF1 PF07741.13 CDI84035.1 - 6.5e-06 26.4 3.6 6.5e-06 26.4 3.6 2.6 4 0 0 4 4 4 1 Brf1-like TBP-binding domain DUF4503 PF14951.6 CDI84035.1 - 0.056 11.9 5.0 0.31 9.4 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4503) XRCC4 PF06632.12 CDI84035.1 - 0.67 8.7 4.0 0.52 9.1 1.9 1.8 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF5345 PF17280.2 CDI84035.1 - 4.2 7.4 8.9 0.39 10.7 0.1 3.2 3 1 1 4 4 4 0 Family of unknown function (DUF5345) SR-25 PF10500.9 CDI84037.1 - 0.23 11.1 28.9 0.19 11.3 10.8 2.7 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein BBP1_N PF15271.6 CDI84037.1 - 2.5 8.9 7.1 0.41 11.4 0.2 2.1 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein FXMRP1_C_core PF12235.8 CDI84038.1 - 5.4 7.7 21.1 7.9 7.1 21.1 1.3 1 1 0 1 1 1 0 Fragile X-related 1 protein core C terminal TMEM208_SND2 PF05620.11 CDI84040.1 - 0.013 15.3 1.5 0.013 15.3 1.5 2.6 1 1 1 2 2 1 0 SRP-independent targeting protein 2/TMEM208 SLC12 PF03522.15 CDI84040.1 - 0.043 12.8 15.2 0.045 12.8 15.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 CDI84040.1 - 0.062 12.7 12.4 0.082 12.3 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 CDI84040.1 - 0.17 10.1 17.8 0.19 10.0 17.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDI84040.1 - 0.19 10.5 23.9 0.23 10.2 23.9 1.1 1 0 0 1 1 1 0 Presenilin Sporozoite_P67 PF05642.11 CDI84040.1 - 0.23 9.5 5.9 0.25 9.4 5.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen LicD PF04991.13 CDI84040.1 - 0.28 11.3 12.6 0.38 10.8 12.6 1.2 1 0 0 1 1 1 0 LicD family V_ATPase_I PF01496.19 CDI84040.1 - 0.32 8.9 19.8 0.37 8.6 19.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 CDI84040.1 - 0.32 10.2 12.2 0.41 9.8 12.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GAGA_bind PF06217.12 CDI84040.1 - 0.4 10.9 18.0 0.49 10.6 18.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF1980 PF09323.10 CDI84040.1 - 0.43 10.5 9.3 0.66 9.9 9.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Serinc PF03348.15 CDI84040.1 - 0.44 9.4 8.8 0.6 9.0 8.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) TFIIA PF03153.13 CDI84040.1 - 0.58 10.1 33.9 0.69 9.8 33.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CLN3 PF02487.17 CDI84040.1 - 0.72 8.8 12.8 0.97 8.4 12.8 1.1 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 CDI84040.1 - 0.9 7.9 9.8 1.1 7.6 9.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Endostatin PF06482.11 CDI84040.1 - 0.97 8.8 17.6 1.2 8.6 17.6 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin MMR1 PF08505.10 CDI84040.1 - 1.2 9.3 23.5 1.6 9.0 23.5 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF913 PF06025.12 CDI84040.1 - 1.4 7.8 10.5 1.8 7.5 10.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nucleoside_tran PF01733.18 CDI84040.1 - 1.4 8.2 5.0 2.3 7.5 5.0 1.4 1 0 0 1 1 1 0 Nucleoside transporter O-antigen_lig PF13425.6 CDI84040.1 - 1.6 7.4 13.6 1.9 7.2 13.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PAT1 PF09770.9 CDI84040.1 - 2.1 6.5 28.9 2.8 6.1 28.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 VIR_N PF15912.5 CDI84040.1 - 2.5 7.7 12.9 3 7.4 12.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal NPR3 PF03666.13 CDI84040.1 - 3.6 6.3 20.3 4.6 5.9 20.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 LMBR1 PF04791.16 CDI84040.1 - 5.2 5.8 9.0 5.1 5.9 9.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM60A PF15396.6 CDI84040.1 - 6.7 6.7 17.5 9.1 6.2 17.5 1.3 1 0 0 1 1 1 0 Protein Family FAM60A eIF-3_zeta PF05091.12 CDI84040.1 - 8.6 5.2 23.9 11 4.8 23.9 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ureide_permease PF07168.11 CDI84040.1 - 9.8 4.8 8.1 14 4.3 8.1 1.3 1 0 0 1 1 1 0 Ureide permease ABC_tran PF00005.27 CDI84041.1 - 6.2e-27 94.8 0.0 6.2e-27 94.8 0.0 3.4 3 0 0 3 3 2 1 ABC transporter MecA PF05389.12 CDI84041.1 - 5.5e-06 26.2 11.6 0.00043 20.0 1.4 2.3 2 0 0 2 2 2 2 Negative regulator of genetic competence (MecA) ABC_membrane PF00664.23 CDI84041.1 - 1.9e-05 24.5 1.9 3.1e-05 23.8 0.4 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region Pinin_SDK_memA PF04696.13 CDI84041.1 - 0.00015 21.9 19.8 0.00015 21.9 19.8 3.3 3 0 0 3 3 3 1 pinin/SDK/memA/ protein conserved region Rad17 PF03215.15 CDI84041.1 - 0.00042 20.3 0.1 0.0016 18.4 0.1 2.0 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_21 PF13304.6 CDI84041.1 - 0.0025 17.7 0.1 2.3 7.9 0.1 2.3 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CDI84041.1 - 0.0036 17.7 3.6 0.069 13.6 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TFIIA PF03153.13 CDI84041.1 - 0.0043 17.1 19.7 0.0043 17.1 19.7 2.7 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit CNDH2_C PF16858.5 CDI84041.1 - 0.0058 16.6 27.3 0.085 12.7 7.7 2.3 2 0 0 2 2 2 2 Condensin II complex subunit CAP-H2 or CNDH2, C-term RR_TM4-6 PF06459.12 CDI84041.1 - 0.0085 16.0 23.3 0.16 11.8 8.3 2.4 2 0 0 2 2 2 2 Ryanodine Receptor TM 4-6 AAA_16 PF13191.6 CDI84041.1 - 0.01 16.2 5.0 0.01 16.2 5.0 3.8 3 2 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 CDI84041.1 - 0.018 15.3 0.0 0.018 15.3 0.0 3.2 3 1 0 3 3 2 0 AAA domain PepSY_TM PF03929.16 CDI84041.1 - 0.02 14.6 11.3 0.12 12.0 0.7 2.5 2 0 0 2 2 2 0 PepSY-associated TM region DUF4471 PF14740.6 CDI84041.1 - 0.025 13.8 13.2 0.045 13.0 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PAT1 PF09770.9 CDI84041.1 - 0.052 11.8 42.0 0.15 10.3 15.5 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 SpoIIP PF07454.11 CDI84041.1 - 0.053 13.0 27.8 0.21 11.0 10.6 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) PPL5 PF18168.1 CDI84041.1 - 0.057 12.7 16.0 0.069 12.4 1.9 2.4 2 0 0 2 2 2 0 Prim-pol family 5 DUF4638 PF15472.6 CDI84041.1 - 0.065 13.0 21.1 0.44 10.3 5.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) AAA_18 PF13238.6 CDI84041.1 - 0.071 13.7 0.1 0.071 13.7 0.1 3.5 4 0 0 4 4 3 0 AAA domain RsgA_GTPase PF03193.16 CDI84041.1 - 0.075 12.9 0.3 0.075 12.9 0.3 2.6 3 0 0 3 3 1 0 RsgA GTPase PRK PF00485.18 CDI84041.1 - 0.082 12.6 0.0 0.082 12.6 0.0 2.2 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 CDI84041.1 - 0.16 12.2 0.0 0.16 12.2 0.0 4.2 4 1 0 4 4 3 0 AAA domain CAF1 PF04857.20 CDI84041.1 - 0.17 11.0 14.4 0.54 9.4 1.7 2.3 2 0 0 2 2 2 0 CAF1 family ribonuclease TsaE PF02367.17 CDI84041.1 - 0.18 11.8 1.9 0.17 11.9 0.2 1.8 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CCSAP PF15748.5 CDI84041.1 - 0.19 11.9 34.8 0.67 10.1 6.9 2.4 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated NST1 PF13945.6 CDI84041.1 - 0.19 11.8 47.9 1.6 8.8 25.6 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF2828 PF11443.8 CDI84041.1 - 0.22 9.5 22.9 0.098 10.7 4.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) MDM31_MDM32 PF08118.11 CDI84041.1 - 0.26 9.9 18.5 0.025 13.3 1.6 2.2 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins SID-1_RNA_chan PF13965.6 CDI84041.1 - 0.39 9.1 9.9 0.47 8.8 1.4 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF5523 PF17661.1 CDI84041.1 - 0.45 10.2 26.9 1.2 8.8 5.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RPA43_OB PF17875.1 CDI84041.1 - 0.66 10.6 17.4 3.6 8.2 7.3 2.8 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Vfa1 PF08432.10 CDI84041.1 - 1.5 9.1 30.4 4.7 7.5 8.8 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 CDI84041.1 - 1.5 7.5 39.0 0.7 8.6 17.7 2.3 2 0 0 2 2 2 0 Presenilin Serinc PF03348.15 CDI84041.1 - 1.6 7.6 15.6 0.061 12.2 0.8 2.4 2 0 0 2 2 2 0 Serine incorporator (Serinc) BORG_CEP PF14957.6 CDI84041.1 - 1.9 9.7 30.2 6.1 8.0 14.3 2.8 2 0 0 2 2 2 0 Cdc42 effector Peptidase_U57 PF05582.12 CDI84041.1 - 1.9 7.7 19.4 0.48 9.6 3.0 2.4 2 0 0 2 2 2 0 YabG peptidase U57 Connexin PF00029.19 CDI84041.1 - 2.1 8.1 23.4 3 7.5 5.6 2.3 2 0 0 2 2 2 0 Connexin Draxin PF15550.6 CDI84041.1 - 2.8 7.7 22.3 2.5 7.9 9.8 2.4 2 0 0 2 2 2 0 Draxin eIF-3_zeta PF05091.12 CDI84041.1 - 3 6.7 37.1 0.97 8.3 14.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF2052 PF09747.9 CDI84041.1 - 3.3 7.8 34.6 0.66 10.1 12.6 2.5 3 0 0 3 3 2 0 Coiled-coil domain containing protein (DUF2052) SRP-alpha_N PF04086.13 CDI84041.1 - 3.5 7.5 33.3 0.72 9.7 5.4 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal RPN2_C PF18004.1 CDI84041.1 - 4.2 7.3 27.6 3.7 7.4 10.8 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Apt1 PF10351.9 CDI84041.1 - 4.5 6.0 30.8 0.0048 15.8 9.8 2.5 3 0 0 3 3 2 0 Golgi-body localisation protein domain Anoctamin PF04547.12 CDI84041.1 - 4.7 5.9 5.8 2.1 7.1 0.6 2.1 2 0 0 2 2 2 0 Calcium-activated chloride channel BUD22 PF09073.10 CDI84041.1 - 5.1 6.3 31.6 4 6.7 2.9 2.3 2 0 0 2 2 2 0 BUD22 BSMAP PF12280.8 CDI84041.1 - 5.2 7.2 22.0 7.1 6.8 6.7 2.4 2 0 0 2 2 2 0 Brain specific membrane anchored protein Peroxin-13_N PF04088.13 CDI84041.1 - 5.3 7.3 18.0 12 6.2 6.5 3.0 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Peptidase_C58 PF03543.14 CDI84041.1 - 5.5 6.6 33.5 0.43 10.3 14.0 2.7 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen MAT1 PF06391.13 CDI84041.1 - 5.9 6.7 38.9 0.29 11.0 12.8 2.8 3 0 0 3 3 2 0 CDK-activating kinase assembly factor MAT1 UBA_e1_thiolCys PF10585.9 CDI84041.1 - 6 6.7 23.0 0.044 13.7 3.7 2.7 3 0 0 3 3 3 0 Ubiquitin-activating enzyme active site PTPRCAP PF15713.5 CDI84041.1 - 6.1 7.1 34.8 1.9 8.7 14.8 2.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Ndc1_Nup PF09531.10 CDI84041.1 - 6.2 5.4 27.0 5.3 5.6 12.7 2.3 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Endostatin PF06482.11 CDI84041.1 - 7.4 5.9 25.9 1.3 8.4 7.6 2.5 3 0 0 3 3 2 0 Collagenase NC10 and Endostatin Hydin_ADK PF17213.3 CDI84041.1 - 7.7 6.7 31.4 0.72 10.1 6.6 2.8 3 0 0 3 3 2 0 Hydin Adenylate kinase-like domain Dynamin_N PF00350.23 CDI84041.1 - 9.1 6.3 21.4 0.44 10.6 4.0 2.9 3 0 0 3 3 2 0 Dynamin family Metallophos PF00149.28 CDI84043.1 - 1.1e-42 146.9 0.0 1.2e-30 107.6 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDI84043.1 - 0.0023 18.4 1.0 0.005 17.2 1.0 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain 8TM_micro PF17028.5 CDI84043.1 - 0.047 13.4 0.8 8.4 6.0 0.1 2.1 1 1 1 2 2 2 0 8TM Microsporidial transmembrane domain DUF5378 PF17349.2 CDI84043.1 - 0.081 12.2 0.9 9.3 5.5 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5378) FlxA PF14282.6 CDI84043.1 - 0.23 11.5 0.7 0.39 10.7 0.7 1.3 1 0 0 1 1 1 0 FlxA-like protein DUF4798 PF16055.5 CDI84043.1 - 1 9.7 2.7 1.8 8.8 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4798) DUF2722 PF10846.8 CDI84044.1 - 0.00082 18.4 5.1 0.00082 18.4 5.1 5.8 5 1 1 6 6 6 1 Protein of unknown function (DUF2722) WES_acyltransf PF03007.16 CDI84045.1 - 0.022 14.5 9.8 0.03 14.1 9.8 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain ALMT PF11744.8 CDI84045.1 - 0.13 11.1 5.3 0.17 10.7 5.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Draxin PF15550.6 CDI84045.1 - 0.22 11.4 10.8 0.27 11.1 10.8 1.0 1 0 0 1 1 1 0 Draxin Raftlin PF15250.6 CDI84045.1 - 0.53 9.0 10.0 0.6 8.8 10.0 1.1 1 0 0 1 1 1 0 Raftlin UPF0560 PF10577.9 CDI84045.1 - 0.54 8.7 17.6 0.58 8.6 17.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TFIIA PF03153.13 CDI84045.1 - 0.63 10.0 29.9 0.92 9.4 29.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YscJ_FliF_C PF08345.11 CDI84045.1 - 0.9 9.9 17.0 1.2 9.5 17.0 1.1 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal Peptidase_S64 PF08192.11 CDI84045.1 - 1.3 7.5 9.6 1.4 7.4 9.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF913 PF06025.12 CDI84045.1 - 1.6 7.6 7.1 1.9 7.4 7.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Miga PF10265.9 CDI84045.1 - 1.7 7.5 7.8 2.1 7.2 7.8 1.1 1 0 0 1 1 1 0 Mitoguardin DUF4769 PF15992.5 CDI84045.1 - 1.8 8.3 10.5 2.3 8.0 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) Band_3_cyto PF07565.13 CDI84045.1 - 1.9 8.2 9.0 2.2 8.0 9.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MecA PF05389.12 CDI84045.1 - 2.3 7.8 7.2 3 7.4 7.2 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Connexin PF00029.19 CDI84045.1 - 3 7.5 6.7 3.7 7.3 6.7 1.2 1 0 0 1 1 1 0 Connexin eIF-3_zeta PF05091.12 CDI84045.1 - 3.3 6.6 15.5 4.2 6.2 15.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PPL5 PF18168.1 CDI84045.1 - 3.5 6.8 8.1 4.2 6.6 8.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Med15 PF09606.10 CDI84045.1 - 6.4 5.3 29.5 8.6 4.9 29.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ndc1_Nup PF09531.10 CDI84045.1 - 6.5 5.3 12.3 6.8 5.2 12.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDRGK PF09756.9 CDI84045.1 - 6.8 6.2 15.6 8.8 5.9 15.6 1.1 1 0 0 1 1 1 0 DDRGK domain Peptidase_S15 PF02129.18 CDI84047.1 - 3.3e-26 92.5 11.9 2.8e-25 89.5 0.0 4.5 4 1 0 4 4 4 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 CDI84047.1 - 1.7e-11 44.5 0.0 1.7e-11 44.5 0.0 3.5 3 1 0 3 3 3 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 CDI84047.1 - 0.028 13.7 0.0 0.028 13.7 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CDI84047.1 - 0.03 13.8 0.6 0.1 12.0 0.6 1.9 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CDI84047.1 - 0.14 12.8 2.2 0.14 12.7 0.1 2.0 2 1 0 2 2 2 0 Alpha/beta hydrolase family Zip PF02535.22 CDI84047.1 - 0.26 10.4 15.7 0.62 9.2 15.7 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIA PF03153.13 CDI84047.1 - 0.5 10.3 30.9 0.012 15.6 14.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF3446 PF11928.8 CDI84048.1 - 0.35 11.2 39.4 0.36 11.2 1.3 4.2 4 0 0 4 4 4 0 Early growth response N-terminal domain Hat1_N PF10394.9 CDI84050.1 - 0.0017 18.7 0.0 0.0031 17.8 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus SUIM_assoc PF16619.5 CDI84050.1 - 0.0023 18.0 1.7 0.0023 18.0 1.7 5.6 4 2 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI84050.1 - 0.0061 16.2 33.0 0.039 13.6 2.0 4.4 4 0 0 4 4 4 3 Spt20 family DUF2722 PF10846.8 CDI84050.1 - 0.36 9.7 29.2 0.048 12.6 1.3 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) Kinesin PF00225.23 CDI84051.1 - 1.4e-62 211.6 0.6 1.4e-62 211.6 0.6 2.7 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 CDI84051.1 - 3.2e-12 46.6 0.9 3.2e-12 46.6 0.9 2.8 2 1 0 2 2 2 1 Microtubule binding TetR_C_25 PF17933.1 CDI84051.1 - 0.017 15.5 1.7 0.23 11.8 0.0 2.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain NUC130_3NT PF08158.12 CDI84051.1 - 0.17 12.3 1.2 0.74 10.2 1.4 1.9 2 0 0 2 2 2 0 NUC130/3NT domain SUIM_assoc PF16619.5 CDI84052.1 - 0.0016 18.5 18.1 0.0034 17.4 1.8 4.7 4 0 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 Nha1_C PF08619.10 CDI84052.1 - 0.059 12.6 0.1 0.059 12.6 0.1 3.1 3 1 0 3 3 3 0 Alkali metal cation/H+ antiporter Nha1 C terminus CbtA PF09490.10 CDI84053.1 - 7.8 6.2 13.8 0.76 9.5 6.7 2.6 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) PA14 PF07691.12 CDI84054.1 - 2e-15 56.9 0.0 5.3e-15 55.5 0.0 1.8 1 0 0 1 1 1 1 PA14 domain Shadoo PF14999.6 CDI84054.1 - 0.53 10.4 19.3 1.5 8.9 3.6 2.6 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective TFIIA PF03153.13 CDI84054.1 - 1.3 8.9 11.7 0.059 13.4 5.9 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit cwf18 PF08315.12 CDI84055.1 - 1e-24 87.8 0.6 1e-24 87.8 0.6 2.0 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor DUF3464 PF11947.8 CDI84055.1 - 2.2 8.0 4.2 1.1 9.1 2.2 1.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF866 PF05907.13 CDI84056.1 - 4.1e-11 43.0 4.7 9.9e-10 38.5 0.0 2.9 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF866) Fer4_4 PF12800.7 CDI84056.1 - 0.11 13.0 2.0 0.21 12.2 2.0 1.3 1 0 0 1 1 1 0 4Fe-4S binding domain Macoilin PF09726.9 CDI84056.1 - 0.45 9.0 25.6 0.47 9.0 25.6 1.1 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CDI84056.1 - 1.1 9.2 18.9 1.1 9.1 18.9 1.1 1 0 0 1 1 1 0 SPX domain PPP4R2 PF09184.11 CDI84056.1 - 1.4 8.4 14.0 1.5 8.4 14.0 1.1 1 0 0 1 1 1 0 PPP4R2 Apt1 PF10351.9 CDI84056.1 - 2.5 6.9 22.6 2.6 6.8 22.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Raftlin PF15250.6 CDI84056.1 - 3.9 6.1 10.2 4.3 6.0 10.2 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 CDI84056.1 - 5.6 5.6 13.3 6.6 5.4 13.3 1.1 1 0 0 1 1 1 0 Presenilin ThiF PF00899.21 CDI84060.1 - 0.042 13.2 0.1 0.05 12.9 0.1 1.1 1 0 0 1 1 1 0 ThiF family DUF508 PF04370.12 CDI84060.1 - 0.055 13.2 4.1 0.059 13.1 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF508) SUZ PF12752.7 CDI84060.1 - 0.17 12.6 2.5 0.17 12.6 2.5 1.1 1 0 0 1 1 1 0 SUZ domain DUF1635 PF07795.11 CDI84060.1 - 0.47 10.3 2.4 0.59 10.0 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) SR-25 PF10500.9 CDI84060.1 - 8 6.0 21.2 9.4 5.8 21.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PRIMA1 PF16101.5 CDI84061.1 - 0.44 10.6 5.4 1.2 9.2 5.4 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Olduvai PF06758.13 CDI84061.1 - 5.2 7.4 7.1 0.32 11.3 0.5 2.4 2 0 0 2 2 2 0 Olduvai domain Pkinase PF00069.25 CDI84062.1 - 5.7e-58 196.4 4.0 6.6e-56 189.6 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84062.1 - 2.2e-18 66.5 0.9 1e-15 57.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CDI84062.1 - 3.4e-05 23.9 9.1 0.00077 19.5 7.5 2.8 1 1 1 2 2 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDI84062.1 - 4e-05 22.6 3.1 0.043 12.6 0.0 2.1 2 0 0 2 2 2 2 Fungal protein kinase EPL1 PF10513.9 CDI84062.1 - 0.0011 19.3 2.5 0.0019 18.6 2.5 1.4 1 0 0 1 1 1 1 Enhancer of polycomb-like Kdo PF06293.14 CDI84062.1 - 0.0029 17.0 0.0 0.0063 15.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIA PF03153.13 CDI84062.1 - 0.0075 16.3 19.5 0.0099 15.9 19.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 CDI84062.1 - 0.01 16.1 0.4 0.013 15.7 0.4 1.3 1 0 0 1 1 1 1 DDHD domain Hid1 PF12722.7 CDI84062.1 - 0.094 10.8 1.9 0.14 10.3 1.9 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDK2AP PF09806.9 CDI84062.1 - 0.12 12.4 15.8 0.21 11.6 15.8 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Choline_kinase PF01633.20 CDI84062.1 - 0.12 11.9 0.1 0.12 11.9 0.1 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase TFB6 PF17110.5 CDI84062.1 - 0.14 11.9 5.1 6.8 6.4 3.6 2.4 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF2722 PF10846.8 CDI84062.1 - 0.17 10.8 16.2 0.25 10.2 16.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Menin PF05053.13 CDI84062.1 - 0.23 9.8 11.7 0.33 9.3 11.7 1.1 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 CDI84062.1 - 0.29 10.1 5.6 0.39 9.7 5.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RIFIN PF02009.16 CDI84062.1 - 0.35 10.7 6.5 0.51 10.2 6.5 1.2 1 0 0 1 1 1 0 Rifin Ndc1_Nup PF09531.10 CDI84062.1 - 0.75 8.4 6.2 0.99 8.0 6.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FTA2 PF13095.6 CDI84062.1 - 0.85 9.2 0.0 0.85 9.2 0.0 2.7 1 1 0 2 2 1 0 Kinetochore Sim4 complex subunit FTA2 Roughex PF06020.11 CDI84062.1 - 0.87 8.6 10.2 1.4 7.9 10.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein TERB2 PF15101.6 CDI84062.1 - 0.89 9.6 8.9 1.7 8.7 8.9 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4407 PF14362.6 CDI84062.1 - 1.5 8.1 14.1 2.3 7.5 14.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Neur_chan_memb PF02932.16 CDI84062.1 - 1.9 8.5 4.3 2.9 7.9 4.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region P16-Arc PF04699.14 CDI84062.1 - 2.5 8.6 7.9 5.9 7.4 7.9 1.6 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Presenilin PF01080.17 CDI84062.1 - 3.4 6.3 13.5 4.9 5.8 13.5 1.1 1 0 0 1 1 1 0 Presenilin BAT2_N PF07001.11 CDI84062.1 - 5 7.5 22.5 7.9 6.9 22.5 1.2 1 0 0 1 1 1 0 BAT2 N-terminus Caldesmon PF02029.15 CDI84063.1 - 0.00054 18.8 54.7 0.00054 18.8 54.7 7.2 8 2 0 8 8 8 2 Caldesmon DUF4201 PF13870.6 CDI84066.1 - 0.0065 16.2 12.9 0.0065 16.2 12.9 4.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4201) TBP PF00352.21 CDI84067.1 - 4e-18 65.1 0.0 2.1e-10 40.4 0.0 2.6 2 1 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF2339 PF10101.9 CDI84067.1 - 6e-05 21.8 8.5 6.3e-05 21.8 8.5 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) DUF2722 PF10846.8 CDI84067.1 - 0.0024 16.9 3.2 0.003 16.6 3.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Peptidase_S49_N PF08496.10 CDI84067.1 - 0.0025 17.9 3.6 0.0056 16.8 3.6 1.5 1 0 0 1 1 1 1 Peptidase family S49 N-terminal TFIIA PF03153.13 CDI84067.1 - 0.035 14.1 25.1 0.0098 15.9 22.4 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CD20 PF04103.15 CDI84067.1 - 0.067 13.3 0.6 0.13 12.3 0.2 1.7 1 1 0 1 1 1 0 CD20-like family Med15 PF09606.10 CDI84067.1 - 0.095 11.4 19.6 0.14 10.8 19.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal HTH_27 PF13463.6 CDI84067.1 - 0.12 12.9 0.2 0.32 11.5 0.2 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain YjbH PF06082.11 CDI84067.1 - 1.8 7.3 7.5 2.3 6.9 7.5 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Atrophin-1 PF03154.15 CDI84067.1 - 6.6 4.9 19.1 9.4 4.4 19.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family ATP-synt_ab PF00006.25 CDI84068.1 - 4.3e-59 199.7 0.0 6.2e-59 199.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 CDI84068.1 - 1.1e-40 138.3 0.0 1.8e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 CDI84068.1 - 3.5e-09 37.0 0.1 9.3e-09 35.7 0.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain cNMP_binding PF00027.29 CDI84071.1 - 2.8e-16 59.4 0.6 1.7e-06 28.0 0.1 3.4 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain AAA_11 PF13086.6 CDI84071.1 - 0.027 14.2 26.8 0.035 13.9 4.6 2.4 2 0 0 2 2 2 0 AAA domain HNOBA PF07701.14 CDI84071.1 - 0.052 13.0 10.8 0.27 10.7 2.5 2.3 2 0 0 2 2 2 0 Heme NO binding associated EPL1 PF10513.9 CDI84071.1 - 0.075 13.4 23.5 0.46 10.9 5.8 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like Presenilin PF01080.17 CDI84071.1 - 0.093 11.5 35.1 0.036 12.9 8.5 2.2 2 0 0 2 2 2 0 Presenilin SpoIIP PF07454.11 CDI84071.1 - 1.1 8.7 30.1 0.42 10.0 7.4 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) NST1 PF13945.6 CDI84071.1 - 1.1 9.3 35.3 0.15 12.1 10.1 2.5 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF4471 PF14740.6 CDI84071.1 - 1.3 8.2 13.2 3.3 6.8 1.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Apt1 PF10351.9 CDI84071.1 - 1.4 7.7 20.7 1.2 8.0 6.1 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Endostatin PF06482.11 CDI84071.1 - 1.5 8.2 27.4 1.2 8.5 9.4 2.4 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Zip PF02535.22 CDI84071.1 - 3.4 6.8 15.4 0.9 8.7 2.1 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Lin-8 PF03353.15 CDI84071.1 - 5.4 6.5 36.1 1.3 8.5 10.3 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Raftlin PF15250.6 CDI84071.1 - 5.6 5.6 23.3 2.5 6.8 9.9 2.3 2 0 0 2 2 2 0 Raftlin MFAP1 PF06991.11 CDI84072.1 - 4.4e-66 222.8 31.5 4.4e-66 222.8 31.5 2.5 2 1 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing FF PF01846.19 CDI84073.1 - 1.4e-16 60.4 0.7 9.4e-10 38.5 0.0 4.4 4 0 0 4 4 4 2 FF domain WW PF00397.26 CDI84073.1 - 1.5e-16 60.2 9.7 1.1e-09 38.2 2.3 2.7 2 0 0 2 2 2 2 WW domain TetR_C_11 PF16859.5 CDI84073.1 - 0.0024 18.2 0.9 0.006 16.9 0.7 1.8 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_7 PF14246.6 CDI84073.1 - 0.031 14.3 0.7 1.6 8.8 0.0 2.6 1 1 1 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain PI3K_1B_p101 PF10486.9 CDI84073.1 - 0.9 7.2 19.4 1.5 6.5 19.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF913 PF06025.12 CDI84073.1 - 3.7 6.4 9.5 8.1 5.3 9.5 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) YTH PF04146.15 CDI84074.1 - 7.6e-14 52.0 0.2 3.3e-07 30.4 0.0 2.9 2 1 0 2 2 2 2 YT521-B-like domain SUIM_assoc PF16619.5 CDI84074.1 - 0.054 13.6 2.9 0.099 12.7 2.9 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DnaJ PF00226.31 CDI84075.1 - 2e-13 50.3 0.0 1.6e-12 47.3 0.0 2.4 1 1 0 1 1 1 1 DnaJ domain PMSI1 PF15322.6 CDI84075.1 - 0.048 13.1 3.5 0.066 12.7 3.5 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative DUF755 PF05501.11 CDI84075.1 - 1.6 9.0 24.4 4.5 7.6 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) MRI PF15325.6 CDI84075.1 - 1.9 9.6 8.0 0.55 11.3 3.8 2.2 2 0 0 2 2 2 0 Modulator of retrovirus infection SUZ PF12752.7 CDI84075.1 - 2.2 9.1 9.6 0.28 12.0 2.6 2.7 2 1 0 2 2 2 0 SUZ domain DUF2877 PF11392.8 CDI84077.1 - 1.6 9.4 5.3 38 5.0 1.4 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) DDHD PF02862.17 CDI84077.1 - 6.3 6.9 10.6 1.9 8.6 3.2 2.9 3 0 0 3 3 3 0 DDHD domain Peptidase_S8 PF00082.22 CDI84081.1 - 1.2e-47 162.6 0.3 1.9e-47 162.0 0.3 1.3 1 0 0 1 1 1 1 Subtilase family BRF1 PF07741.13 CDI84082.1 - 0.47 10.8 8.5 22 5.5 4.5 3.2 3 0 0 3 3 3 0 Brf1-like TBP-binding domain Helo_like_N PF17111.5 CDI84082.1 - 5.9 6.2 9.8 0.77 9.1 0.6 2.4 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Activator_LAG-3 PF11498.8 CDI84082.1 - 6.3 5.7 21.5 0.21 10.5 14.3 2.0 2 0 0 2 2 2 0 Transcriptional activator LAG-3 Glyco_transf_17 PF04724.13 CDI84083.1 - 3.1e-19 69.2 0.2 1.8e-18 66.7 0.2 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 17 Spore_coat_CotO PF14153.6 CDI84083.1 - 0.0015 18.5 10.7 0.003 17.5 10.7 1.5 1 0 0 1 1 1 1 Spore coat protein CotO TFIIA PF03153.13 CDI84083.1 - 0.0049 16.9 27.1 0.0049 16.9 27.1 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit MID_MedPIWI PF18296.1 CDI84083.1 - 0.017 15.0 8.1 0.098 12.4 4.6 2.4 2 0 0 2 2 2 0 MID domain of medPIWI DDHD PF02862.17 CDI84083.1 - 0.018 15.2 9.3 84 3.2 16.1 2.2 1 1 1 2 2 2 0 DDHD domain Ndc1_Nup PF09531.10 CDI84083.1 - 0.064 11.9 3.4 0.096 11.4 3.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 CDI84083.1 - 0.17 10.7 17.4 0.18 10.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) Zip PF02535.22 CDI84083.1 - 0.25 10.5 2.6 0.24 10.6 1.3 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter Esterase PF00756.20 CDI84083.1 - 0.35 10.5 6.4 0.65 9.6 6.4 1.3 1 0 0 1 1 1 0 Putative esterase DUF4228 PF14009.6 CDI84083.1 - 0.41 11.0 5.3 0.12 12.7 2.1 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4228) Neur_chan_memb PF02932.16 CDI84083.1 - 0.46 10.5 10.5 1.5 8.8 8.3 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PepSY_TM PF03929.16 CDI84083.1 - 0.99 9.0 2.9 2.3 7.8 2.9 1.7 1 0 0 1 1 1 0 PepSY-associated TM region Suf PF05843.14 CDI84083.1 - 1.3 8.9 17.9 2.7 7.9 17.9 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PAT1 PF09770.9 CDI84083.1 - 1.4 7.1 25.1 2.3 6.4 25.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Raftlin PF15250.6 CDI84083.1 - 2 7.1 15.5 0.93 8.2 12.8 1.7 2 0 0 2 2 2 0 Raftlin DUF775 PF05603.12 CDI84083.1 - 2 7.9 10.5 5.8 6.4 10.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Membralin PF09746.9 CDI84083.1 - 2.1 7.3 5.0 3.3 6.6 5.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein NPR3 PF03666.13 CDI84083.1 - 2.3 6.9 17.4 4.1 6.1 17.4 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 CDI84083.1 - 2.5 6.8 18.9 4.8 5.8 18.9 1.3 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 CDI84083.1 - 2.8 6.3 11.0 4.4 5.7 11.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF913 PF06025.12 CDI84083.1 - 3.1 6.7 7.1 5.4 5.9 7.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 CDI84083.1 - 3.3 7.7 14.1 6.3 6.7 14.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF4638 PF15472.6 CDI84083.1 - 3.5 7.3 11.9 5.8 6.6 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Dicty_REP PF05086.12 CDI84083.1 - 4.6 5.1 8.0 6.5 4.6 8.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SLC12 PF03522.15 CDI84083.1 - 5.7 5.8 14.8 9 5.2 14.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 CDI84083.1 - 6.2 6.6 19.2 12 5.6 19.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 N6_N4_Mtase PF01555.18 CDI84083.1 - 6.9 6.3 6.7 19 4.8 6.7 1.7 1 1 0 1 1 1 0 DNA methylase MCM_bind PF09739.9 CDI84083.1 - 8.6 4.7 18.1 13 4.1 18.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Tim54 PF11711.8 CDI84083.1 - 8.7 5.0 14.3 19 3.9 14.3 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Borrelia_P83 PF05262.11 CDI84083.1 - 9 4.7 13.9 13 4.1 13.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein PP2C PF00481.21 CDI84084.1 - 7.7e-18 65.0 0.0 7.7e-18 65.0 0.0 2.3 3 1 0 3 3 3 1 Protein phosphatase 2C SpoIIE PF07228.12 CDI84084.1 - 0.004 17.1 0.0 0.012 15.6 0.0 1.8 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) SOBP PF15279.6 CDI84084.1 - 4.9 7.7 14.7 6.9 7.2 14.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein HABP4_PAI-RBP1 PF04774.15 CDI84085.1 - 9.1e-20 71.6 8.0 9.1e-20 71.6 8.0 3.5 3 1 1 4 4 4 1 Hyaluronan / mRNA binding family Spt20 PF12090.8 CDI84085.1 - 0.2 11.2 5.5 0.41 10.2 5.5 1.5 1 0 0 1 1 1 0 Spt20 family ORC6 PF05460.13 CDI84085.1 - 6.3 6.0 9.5 0.43 9.8 0.8 2.1 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) CEP44 PF15007.6 CDI84086.1 - 5e-44 149.5 0.0 1.7e-43 147.8 0.0 1.9 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 Mrx7 PF10906.8 CDI84086.1 - 2.1 8.7 7.0 0.67 10.3 0.1 3.5 4 0 0 4 4 4 0 MIOREX complex component 7 RRM_1 PF00076.22 CDI84088.1 - 2.2e-08 33.8 0.0 0.19 11.5 0.0 4.0 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_60s PF00428.19 CDI84089.1 - 3.3 8.4 33.7 0.52 10.9 4.2 5.0 5 0 0 5 5 5 0 60s Acidic ribosomal protein Mitofilin PF09731.9 CDI84091.1 - 0.41 9.4 40.8 0.49 9.2 40.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein AF-4 PF05110.13 CDI84091.1 - 0.52 8.3 31.8 0.65 8.0 31.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIF_alpha PF05793.12 CDI84091.1 - 1.9 7.0 22.0 2.4 6.6 22.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF966 PF06136.13 CDI84091.1 - 3.6 7.2 28.3 4.5 6.9 28.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF4778 PF16008.5 CDI84091.1 - 4.7 7.2 16.5 5.8 6.9 16.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Macoilin PF09726.9 CDI84091.1 - 5.2 5.5 21.2 7.1 5.0 21.2 1.2 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 CDI84091.1 - 5.9 5.0 16.1 8 4.6 16.1 1.2 1 0 0 1 1 1 0 CDC45-like protein SOBP PF15279.6 CDI84091.1 - 9.5 6.7 23.9 13 6.3 23.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein RskA PF10099.9 CDI84092.1 - 0.00019 21.8 2.8 0.00019 21.8 2.8 4.7 1 1 0 3 3 3 2 Anti-sigma-K factor rskA CPSase_L_D2 PF02786.17 CDI84094.1 - 3e-105 350.4 0.5 1.1e-70 237.4 0.1 3.2 2 1 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CDI84094.1 - 1.4e-16 60.9 0.2 3.7e-16 59.6 0.2 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.13 CDI84094.1 - 3.6e-16 59.3 0.6 9e-08 31.9 0.1 3.2 2 1 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CDI84094.1 - 3.6e-15 55.9 0.1 3.9e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.22 CDI84094.1 - 1.9e-14 53.6 0.2 4.1e-09 36.2 0.1 3.0 2 1 1 3 3 3 2 ATP-grasp domain MGS PF02142.22 CDI84094.1 - 5.8e-12 45.6 0.2 7.4e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 MGS-like domain ATP-grasp_3 PF02655.14 CDI84094.1 - 1.2e-06 28.7 0.1 0.0044 17.1 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 CDI84094.1 - 0.042 13.6 0.0 0.13 12.1 0.0 1.8 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.6 CDI84094.1 - 0.082 12.4 0.0 0.25 10.8 0.2 1.7 2 0 0 2 2 2 0 ATP-grasp domain TTL PF03133.15 CDI84094.1 - 0.092 11.8 0.0 8.6 5.4 0.0 2.6 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family SUIM_assoc PF16619.5 CDI84094.1 - 2.9 8.0 11.6 0.38 10.9 4.6 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI84094.1 - 3.8 7.1 6.7 7.9 6.0 6.7 1.5 1 0 0 1 1 1 0 Spt20 family CCSAP PF15748.5 CDI84095.1 - 0.0094 16.2 15.8 0.0094 16.2 15.8 7.0 6 1 0 7 7 7 1 Centriole, cilia and spindle-associated Adaptin_binding PF10199.9 CDI84095.1 - 7.5 7.2 0.0 7.5 7.2 0.0 6.0 3 3 1 4 4 4 0 Alpha and gamma adaptin binding protein p34 CAF1 PF04857.20 CDI84095.1 - 8.6 5.4 39.7 3.6 6.7 8.8 4.5 4 1 0 4 4 4 0 CAF1 family ribonuclease CNDH2_C PF16858.5 CDI84096.1 - 1.2e-09 38.5 4.3 3.7e-09 36.9 4.3 1.9 1 1 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term SUIM_assoc PF16619.5 CDI84096.1 - 7.3e-05 22.7 10.5 0.22 11.6 2.3 4.3 3 1 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 CNDH2_N PF06278.11 CDI84096.1 - 0.00012 22.3 0.3 0.00043 20.5 0.0 2.1 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal SR-25 PF10500.9 CDI84096.1 - 1.3 8.6 10.3 1 8.9 0.9 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Sel1 PF08238.12 CDI84098.1 - 9.5e-06 26.1 0.1 9.5e-06 26.1 0.1 4.6 4 0 0 4 4 4 1 Sel1 repeat DUF4471 PF14740.6 CDI84098.1 - 3.5 6.7 11.9 0.32 10.2 5.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) AP2 PF00847.20 CDI84101.1 - 4.8e-08 33.1 0.2 4.8e-08 33.1 0.2 3.0 3 0 0 3 3 3 1 AP2 domain CWC25 PF12542.8 CDI84103.1 - 2.7e-14 53.9 0.1 2.7e-14 53.9 0.1 6.7 3 1 0 3 3 3 1 Pre-mRNA splicing factor SR-25 PF10500.9 CDI84103.1 - 0.0039 16.8 9.7 0.0039 16.8 9.7 6.2 3 1 2 5 5 5 2 Nuclear RNA-splicing-associated protein XPA_C PF05181.12 CDI84104.1 - 0.00015 21.7 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 XPA protein C-terminus Cellulase-like PF12876.7 CDI84104.1 - 0.01 15.2 0.3 0.016 14.6 0.3 1.2 1 0 0 1 1 1 0 Sugar-binding cellulase-like Ion_trans_N PF08412.10 CDI84104.1 - 0.016 14.8 0.0 0.055 13.1 0.0 1.9 1 0 0 1 1 1 0 Ion transport protein N-terminal PIP5K PF01504.18 CDI84104.1 - 3.7 6.7 8.1 3.1 7.0 4.0 2.0 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase GAGA_bind PF06217.12 CDI84104.1 - 7.5 6.7 15.1 7 6.8 1.9 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family Presenilin PF01080.17 CDI84104.1 - 8.9 5.0 19.4 1.1 8.0 10.3 2.1 2 0 0 2 2 2 0 Presenilin DUF572 PF04502.13 CDI84105.1 - 0.00084 19.0 0.1 0.0011 18.7 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Nucleoside_tran PF01733.18 CDI84106.1 - 2.3e-12 46.9 0.4 2.3e-12 46.9 0.4 1.9 2 0 0 2 2 2 1 Nucleoside transporter Spt20 PF12090.8 CDI84106.1 - 0.065 12.8 3.6 0.096 12.3 3.6 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 CDI84106.1 - 0.64 9.9 2.4 2.6 8.0 3.1 1.4 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) RskA PF10099.9 CDI84106.1 - 0.74 10.1 9.0 5 7.4 9.0 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDI84106.1 - 7.1 5.4 8.1 12 4.7 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TAF4 PF05236.14 CDI84106.1 - 7.9 6.1 9.3 0.1 12.3 1.0 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family eIF-5_eIF-2B PF01873.17 CDI84107.1 - 2.5e-35 120.9 0.0 5.1e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Dicty_REP PF05086.12 CDI84107.1 - 0.27 9.2 4.5 0.31 9.0 4.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Nop14 PF04147.12 CDI84107.1 - 1.1 7.4 22.7 1.5 7.0 22.7 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4551 PF15087.6 CDI84107.1 - 1.3 7.8 10.2 1.5 7.5 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GREB1 PF15782.5 CDI84107.1 - 9.4 3.2 7.3 11 3.0 7.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Metallophos_2 PF12850.7 CDI84108.1 - 1.2e-20 74.3 0.0 1.5e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CDI84108.1 - 7.8e-05 23.3 1.8 0.0026 18.3 0.4 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase CHCH PF06747.13 CDI84109.1 - 2.9e-05 24.1 4.4 3.6e-05 23.8 3.2 1.7 1 1 1 2 2 2 2 CHCH domain Pet191_N PF10203.9 CDI84109.1 - 0.1 12.9 4.9 0.14 12.5 4.9 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Pex14_N PF04695.13 CDI84110.1 - 0.012 16.2 6.4 0.022 15.4 6.4 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_L7Ae PF01248.26 CDI84111.1 - 1.1e-22 79.5 1.7 2e-22 78.7 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 CDI84111.1 - 0.033 14.2 0.1 0.058 13.4 0.1 1.4 1 0 0 1 1 1 0 RNase P subunit Pop3 DUF1712 PF08217.11 CDI84112.1 - 2.2e-18 66.1 8.9 1.3e-16 60.3 0.1 2.8 2 1 0 2 2 2 2 Fungal domain of unknown function (DUF1712) AAA_23 PF13476.6 CDI84112.1 - 0.00032 21.2 6.1 0.00057 20.4 6.1 1.5 1 0 0 1 1 1 1 AAA domain Coilin_N PF15862.5 CDI84112.1 - 0.0024 17.7 6.8 0.0024 17.7 6.8 1.9 2 0 0 2 2 1 1 Coilin N-terminus Endostatin PF06482.11 CDI84112.1 - 0.0033 17.0 3.4 0.0066 16.0 3.4 1.5 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin DUF4746 PF15928.5 CDI84112.1 - 0.0068 15.9 12.2 0.014 14.8 7.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4746) DDHD PF02862.17 CDI84112.1 - 0.022 14.9 10.3 0.017 15.3 6.3 2.1 2 0 0 2 2 2 0 DDHD domain Velvet PF11754.8 CDI84112.1 - 0.065 13.2 10.8 0.041 13.8 7.2 2.0 2 0 0 2 2 2 0 Velvet factor Med15 PF09606.10 CDI84112.1 - 0.1 11.2 20.3 0.16 10.6 20.3 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SpoIIP PF07454.11 CDI84112.1 - 0.17 11.3 16.8 0.022 14.2 12.1 1.7 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF4407 PF14362.6 CDI84112.1 - 0.18 11.1 17.1 0.36 10.1 17.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PDCD7 PF16021.5 CDI84112.1 - 0.19 10.8 16.6 0.31 10.1 16.6 1.2 1 0 0 1 1 1 0 Programmed cell death protein 7 DUF2126 PF09899.9 CDI84112.1 - 0.23 9.5 6.5 0.33 9.0 6.5 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SID-1_RNA_chan PF13965.6 CDI84112.1 - 0.25 9.7 1.6 0.34 9.3 1.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF702 PF05142.12 CDI84112.1 - 0.28 11.6 7.9 0.67 10.4 7.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF702) EPL1 PF10513.9 CDI84112.1 - 0.33 11.3 14.4 0.17 12.3 11.2 2.0 2 0 0 2 2 2 0 Enhancer of polycomb-like PepSY_TM PF03929.16 CDI84112.1 - 0.41 10.3 3.5 4.2 6.9 4.7 1.9 2 0 0 2 2 2 0 PepSY-associated TM region DUF4770 PF15994.5 CDI84112.1 - 0.46 10.7 8.6 1.1 9.5 8.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) SLC12 PF03522.15 CDI84112.1 - 0.52 9.3 10.5 1.1 8.2 10.5 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 CDI84112.1 - 0.59 10.1 8.6 0.055 13.5 4.1 1.6 2 0 0 2 2 1 0 Neurotransmitter-gated ion-channel transmembrane region FYDLN_acid PF09538.10 CDI84112.1 - 0.61 10.8 14.4 0.052 14.2 6.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Paramyxo_ncap PF00973.19 CDI84112.1 - 0.64 8.9 5.8 0.98 8.3 5.8 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein GREB1 PF15782.5 CDI84112.1 - 0.65 7.1 8.0 0.9 6.6 8.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer WES_acyltransf PF03007.16 CDI84112.1 - 0.72 9.6 3.5 1.4 8.6 3.2 1.6 2 0 0 2 2 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Ureide_permease PF07168.11 CDI84112.1 - 0.72 8.5 5.2 1.2 7.8 5.2 1.2 1 0 0 1 1 1 0 Ureide permease PA26 PF04636.13 CDI84112.1 - 0.72 8.7 6.3 1.2 8.0 6.3 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) MAJIN PF15077.6 CDI84112.1 - 0.88 9.3 7.9 2 8.2 7.9 1.5 1 0 0 1 1 1 0 Membrane-anchored junction protein FancD2 PF14631.6 CDI84112.1 - 1 6.7 7.1 1.6 6.0 7.1 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease GvpL_GvpF PF06386.11 CDI84112.1 - 1.1 9.2 13.6 2.1 8.2 13.6 1.4 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Suf PF05843.14 CDI84112.1 - 1.1 9.2 13.2 0.051 13.5 7.4 1.7 2 0 0 2 2 1 0 Suppressor of forked protein (Suf) DUF2370 PF10176.9 CDI84112.1 - 1.3 8.6 4.5 2.7 7.6 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) TCP PF03634.13 CDI84112.1 - 1.5 9.3 15.2 0.11 13.0 8.0 2.2 2 0 0 2 2 2 0 TCP family transcription factor TRAP_alpha PF03896.16 CDI84112.1 - 1.7 7.8 12.3 22 4.1 11.8 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF5308 PF17233.2 CDI84112.1 - 1.9 8.7 12.6 0.18 12.1 7.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5308) PAT1 PF09770.9 CDI84112.1 - 2.7 6.2 19.5 4.1 5.5 19.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3292 PF11696.8 CDI84112.1 - 2.7 6.3 8.1 4.1 5.7 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF2052 PF09747.9 CDI84112.1 - 3 7.9 22.5 0.29 11.3 14.5 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.15 CDI84112.1 - 3.1 6.5 13.6 0.023 13.5 4.4 1.8 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein EIIBC-GUT_N PF03612.14 CDI84112.1 - 3.2 7.5 12.7 7.2 6.3 12.7 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RPA43_OB PF17875.1 CDI84112.1 - 3.2 8.4 10.9 8.5 7.0 9.3 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Lin-8 PF03353.15 CDI84112.1 - 3.3 7.2 17.7 0.24 10.9 12.7 1.6 2 0 0 2 2 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 CDI84112.1 - 4.2 5.6 17.7 9.1 4.4 15.4 2.0 2 0 0 2 2 2 0 CDC45-like protein VIR_N PF15912.5 CDI84112.1 - 4.6 6.8 18.0 0.082 12.5 8.5 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal Plasmodium_Vir PF05795.11 CDI84112.1 - 5 6.4 10.2 0.13 11.7 3.6 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein FAM150 PF15129.6 CDI84112.1 - 5.2 7.2 10.4 16 5.6 10.4 1.8 1 0 0 1 1 1 0 FAM150 family NARP1 PF12569.8 CDI84112.1 - 5.2 5.8 15.9 9.5 5.0 15.9 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 eIF-3_zeta PF05091.12 CDI84112.1 - 5.3 5.9 18.3 8.1 5.3 18.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FTZ PF03867.14 CDI84112.1 - 5.6 6.4 9.5 51 3.3 9.6 2.2 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region DUF719 PF05334.13 CDI84112.1 - 7.1 6.8 18.1 0.31 11.2 11.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF719) PTPRCAP PF15713.5 CDI84112.1 - 7.1 6.9 28.8 5 7.4 21.9 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CTU2 PF10288.9 CDI84112.1 - 7.2 6.9 13.0 2 8.7 9.0 2.2 2 0 0 2 2 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Otopetrin PF03189.13 CDI84112.1 - 7.4 5.3 6.6 13 4.4 6.6 1.3 1 0 0 1 1 1 0 Otopetrin MCM_bind PF09739.9 CDI84112.1 - 7.9 4.8 17.6 13 4.1 17.6 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor TFIIA PF03153.13 CDI84112.1 - 8.3 6.3 36.0 0.13 12.2 27.4 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 CDI84112.1 - 8.5 5.7 14.1 17 4.8 14.1 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Eapp_C PF10238.9 CDI84112.1 - 8.6 6.4 16.4 0.48 10.5 10.3 1.9 2 0 0 2 2 1 0 E2F-associated phosphoprotein Sec62 PF03839.16 CDI84112.1 - 9.4 5.7 11.3 19 4.7 11.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 MID_MedPIWI PF18296.1 CDI84112.1 - 9.9 5.9 14.9 5.4 6.7 9.2 2.2 2 0 0 2 2 2 0 MID domain of medPIWI IMCp PF12314.8 CDI84113.1 - 7e-24 83.9 102.1 1.5e-17 63.6 28.1 6.1 1 1 4 6 6 6 5 Inner membrane complex protein HTH_43 PF09904.9 CDI84113.1 - 0.055 13.4 2.3 2.9 7.9 0.1 2.8 3 0 0 3 3 3 0 Winged helix-turn helix ABC2_membrane_2 PF12679.7 CDI84115.1 - 2.3 7.4 13.8 7.1 5.8 4.3 3.2 3 0 0 3 3 3 0 ABC-2 family transporter protein PIG-X PF08320.12 CDI84116.1 - 5.9e-14 52.5 0.0 3.7e-13 49.9 0.0 2.2 1 1 0 1 1 1 1 PIG-X / PBN1 Ribosomal_60s PF00428.19 CDI84116.1 - 0.26 11.9 13.4 3.5 8.3 8.8 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Folate_carrier PF01770.18 CDI84117.1 - 0.009 14.8 2.7 0.03 13.1 2.7 1.8 1 0 0 1 1 1 1 Reduced folate carrier Secretin_N_2 PF07655.13 CDI84117.1 - 2.8 8.5 16.7 1.2 9.7 6.0 3.7 3 0 0 3 3 3 0 Secretin N-terminal domain Peroxin-13_N PF04088.13 CDI84117.1 - 5 7.4 7.0 6.9 6.9 0.3 3.9 3 0 0 3 3 3 0 Peroxin 13, N-terminal region PGA2 PF07543.12 CDI84119.1 - 0.075 13.0 3.3 0.13 12.2 3.3 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 RskA PF10099.9 CDI84119.1 - 0.17 12.2 4.1 0.076 13.3 1.0 1.8 2 0 0 2 2 2 0 Anti-sigma-K factor rskA PNISR PF15996.5 CDI84121.1 - 0.0033 17.7 2.5 0.0033 17.7 2.5 3.8 2 1 0 3 3 3 1 Arginine/serine-rich protein PNISR Spt20 PF12090.8 CDI84121.1 - 0.076 12.6 42.6 0.16 11.6 15.1 2.4 2 0 0 2 2 2 0 Spt20 family TFIIA PF03153.13 CDI84121.1 - 0.16 11.9 49.7 0.22 11.5 15.0 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Mem_trans PF03547.18 CDI84121.1 - 0.18 10.2 0.0 0.19 10.1 0.0 1.3 1 0 0 1 1 1 0 Membrane transport protein UMP1 PF05348.11 CDI84121.1 - 2.3 8.5 13.2 0.54 10.5 1.1 2.4 2 0 0 2 2 2 0 Proteasome maturation factor UMP1 TFIIA PF03153.13 CDI84123.1 - 0.79 9.6 30.2 1.2 9.1 30.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GPCR_chapero_1 PF11904.8 CDI84125.1 - 2.7 7.3 9.9 4.4 6.7 9.9 1.2 1 0 0 1 1 1 0 GPCR-chaperone NAD_binding_1 PF00175.21 CDI84125.1 - 8.3 7.1 7.9 17 6.1 7.9 1.5 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Ras PF00071.22 CDI84126.1 - 3.7e-63 212.0 1.0 5.1e-63 211.5 1.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI84126.1 - 9.9e-36 122.6 0.1 2e-35 121.6 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDI84126.1 - 1.7e-16 60.2 0.2 2.6e-16 59.6 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDI84126.1 - 4.8e-05 22.9 0.1 0.0001 21.8 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDI84126.1 - 0.0001 21.8 0.1 0.00014 21.3 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDI84126.1 - 0.00024 21.1 0.9 0.35 10.8 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDI84126.1 - 0.00027 21.0 0.0 0.00049 20.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDI84126.1 - 0.0005 19.7 0.7 0.001 18.7 0.5 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CDI84126.1 - 0.008 15.9 0.3 0.3 10.8 0.0 2.7 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 CDI84126.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDI84126.1 - 0.11 12.8 0.3 0.25 11.6 0.1 2.0 2 1 0 2 2 1 0 AAA domain AAA_29 PF13555.6 CDI84126.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 CDI84126.1 - 0.14 11.6 0.0 0.58 9.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region LRAT PF04970.13 CDI84126.1 - 0.15 12.4 0.7 0.36 11.2 0.7 1.6 1 0 0 1 1 1 0 Lecithin retinol acyltransferase AAA_16 PF13191.6 CDI84126.1 - 0.16 12.3 3.9 0.42 11.0 2.1 2.6 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CDI84126.1 - 0.2 11.6 7.3 0.86 9.5 0.0 3.6 2 1 0 3 3 3 0 NACHT domain ABC_tran PF00005.27 CDI84126.1 - 1.1 9.8 4.0 3.1 8.3 1.9 2.7 2 1 0 2 2 2 0 ABC transporter zf-CCHC_2 PF13696.6 CDI84127.1 - 9.1e-08 31.8 3.5 2.2e-07 30.6 3.5 1.7 1 0 0 1 1 1 1 Zinc knuckle SUIM_assoc PF16619.5 CDI84127.1 - 0.0015 18.5 29.4 0.0035 17.4 0.0 4.4 4 0 0 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 zf-CCHC PF00098.23 CDI84127.1 - 0.023 14.8 5.2 0.023 14.8 5.2 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-RING_UBOX PF13445.6 CDI84127.1 - 0.061 13.4 4.2 0.19 11.8 4.2 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-CCHC_4 PF14392.6 CDI84127.1 - 0.14 11.9 2.3 0.28 10.9 2.3 1.5 1 0 0 1 1 1 0 Zinc knuckle SRP9-21 PF05486.12 CDI84127.1 - 0.24 11.8 5.3 1.2 9.5 0.3 3.1 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) tRNA_lig_CPD PF08302.11 CDI84127.1 - 1.2 8.5 6.7 2 7.8 1.9 2.8 3 0 0 3 3 3 0 Fungal tRNA ligase phosphodiesterase domain RAB3GAP2_N PF14655.6 CDI84127.1 - 3.7 6.7 10.0 2.5 7.3 0.5 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Thymidylate_kin PF02223.17 CDI84128.1 - 0.00068 19.4 0.6 0.00093 18.9 0.6 1.2 1 0 0 1 1 1 1 Thymidylate kinase RskA PF10099.9 CDI84128.1 - 0.057 13.7 23.7 0.15 12.3 23.7 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI84128.1 - 1.3 9.0 20.2 1.6 8.7 20.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI84129.1 - 1.4 8.9 22.3 0.31 11.0 0.6 3.4 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) TCP PF03634.13 CDI84129.1 - 8.4 6.9 13.1 12 6.5 3.2 3.9 4 0 0 4 4 4 0 TCP family transcription factor SNF2_N PF00176.23 CDI84131.1 - 2.1e-17 62.9 0.6 2.1e-17 62.9 0.6 2.4 3 0 0 3 3 3 1 SNF2 family N-terminal domain TCP PF03634.13 CDI84131.1 - 0.057 14.0 0.5 0.057 14.0 0.5 4.4 4 0 0 4 4 4 0 TCP family transcription factor DUF4079 PF13301.6 CDI84131.1 - 1.4 9.0 0.0 1.4 9.0 0.0 3.2 3 2 0 3 3 3 0 Protein of unknown function (DUF4079) Caldesmon PF02029.15 CDI84132.1 - 0.0024 16.7 41.1 0.0024 16.7 41.1 4.4 2 1 0 2 2 2 1 Caldesmon DUF3089 PF11288.8 CDI84135.1 - 0.13 11.7 0.1 0.21 11.1 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3089) PDZ_3 PF17815.1 CDI84136.1 - 8.5e-21 74.3 0.5 1.9e-20 73.2 0.5 1.5 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 CDI84136.1 - 1.5e-20 74.6 2.1 5.9e-20 72.7 2.1 2.1 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDI84136.1 - 1.7e-11 44.3 0.9 3e-11 43.6 0.0 1.8 2 0 0 2 2 2 1 Trypsin PDZ_6 PF17820.1 CDI84136.1 - 0.0014 18.4 0.3 3.1 7.7 0.0 3.5 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 CDI84136.1 - 0.036 14.4 0.0 4.9 7.5 0.0 2.8 2 0 0 2 2 2 0 PDZ domain Borrelia_P83 PF05262.11 CDI84138.1 - 0.86 8.0 13.3 1 7.7 13.3 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein PmbA_TldD PF01523.16 CDI84138.1 - 4.5 7.0 9.6 7.2 6.4 9.6 1.3 1 0 0 1 1 1 0 Putative modulator of DNA gyrase BAF1_ABF1 PF04684.13 CDI84138.1 - 8.6 5.3 8.2 11 5.0 8.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Kinesin PF00225.23 CDI84140.1 - 1.7e-21 76.5 11.6 1.7e-13 50.3 0.0 5.3 5 1 0 5 5 5 3 Kinesin motor domain MFS_1 PF07690.16 CDI84140.1 - 1.1e-17 64.1 21.0 7.9e-11 41.5 1.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDI84140.1 - 0.00032 19.2 0.3 0.00032 19.2 0.3 2.8 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2722 PF10846.8 CDI84140.1 - 0.0016 17.5 0.1 0.0016 17.5 0.1 4.3 4 1 1 5 5 5 1 Protein of unknown function (DUF2722) Microtub_bd PF16796.5 CDI84140.1 - 0.0021 18.0 2.2 0.0027 17.7 0.0 2.3 2 1 0 2 2 2 1 Microtubule binding Sugar_tr PF00083.24 CDI84140.1 - 0.018 13.9 0.2 0.018 13.9 0.2 2.9 2 1 2 4 4 4 0 Sugar (and other) transporter EMP70 PF02990.16 CDI84140.1 - 1.6 7.3 3.3 12 4.4 2.4 2.2 1 1 0 1 1 1 0 Endomembrane protein 70 DUF1003 PF06210.11 CDI84141.1 - 0.047 13.8 0.1 0.077 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) TFIIA PF03153.13 CDI84141.1 - 4.7 7.1 9.6 5.8 6.8 9.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit tRNA-synt_2b PF00587.25 CDI84142.1 - 8.9e-19 68.1 0.2 1.9e-18 67.1 0.2 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TFIIA PF03153.13 CDI84142.1 - 0.00024 21.2 29.0 0.038 14.0 7.5 2.1 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI84142.1 - 0.00026 21.7 22.0 0.005 17.5 9.3 2.3 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Med15 PF09606.10 CDI84142.1 - 0.0004 19.2 24.7 0.012 14.3 9.4 2.1 2 0 0 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal DDHD PF02862.17 CDI84142.1 - 0.0045 17.2 6.7 0.064 13.4 1.7 2.1 2 0 0 2 2 2 1 DDHD domain DUF2722 PF10846.8 CDI84142.1 - 0.0087 15.1 31.8 0.035 13.1 12.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84142.1 - 0.01 15.4 42.0 0.14 11.7 13.1 2.2 2 0 0 2 2 2 0 Spt20 family DUF2795 PF11387.8 CDI84142.1 - 0.01 16.0 0.3 0.025 14.8 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) MMU163 PF17119.5 CDI84142.1 - 0.045 12.9 6.0 3 6.9 3.0 2.1 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis DUF4834 PF16118.5 CDI84142.1 - 0.051 14.5 18.3 0.92 10.5 7.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Connexin PF00029.19 CDI84142.1 - 0.058 13.2 5.8 0.76 9.5 1.7 2.2 2 0 0 2 2 2 0 Connexin EPL1 PF10513.9 CDI84142.1 - 0.074 13.4 12.9 0.64 10.4 5.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like SET PF00856.28 CDI84142.1 - 0.076 13.4 0.8 3 8.2 0.1 2.2 2 0 0 2 2 2 0 SET domain eIF-3_zeta PF05091.12 CDI84142.1 - 0.12 11.3 15.4 0.33 9.9 5.8 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SpoIIP PF07454.11 CDI84142.1 - 0.16 11.4 11.6 0.44 9.9 4.5 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF1115 PF06544.12 CDI84142.1 - 0.18 11.9 7.2 2.2 8.3 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) CDC45 PF02724.14 CDI84142.1 - 0.2 9.9 7.2 0.34 9.1 2.3 2.0 2 0 0 2 2 2 0 CDC45-like protein FAM176 PF14851.6 CDI84142.1 - 0.23 11.1 8.8 4.7 6.9 0.1 2.2 2 0 0 2 2 2 0 FAM176 family Eapp_C PF10238.9 CDI84142.1 - 0.25 11.4 13.9 2.6 8.1 5.8 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF5327 PF17261.2 CDI84142.1 - 0.27 12.0 24.5 0.63 10.8 11.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) Presenilin PF01080.17 CDI84142.1 - 0.27 10.0 13.8 1.7 7.3 7.7 2.1 2 0 0 2 2 2 0 Presenilin AAA_11 PF13086.6 CDI84142.1 - 0.27 11.0 11.6 0.6 9.8 6.4 2.1 2 0 0 2 2 2 0 AAA domain Band_3_cyto PF07565.13 CDI84142.1 - 0.34 10.7 12.8 1 9.1 5.8 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4771 PF15995.5 CDI84142.1 - 0.35 11.1 7.5 0.14 12.4 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4771) MMR1 PF08505.10 CDI84142.1 - 0.35 11.1 16.4 0.85 9.9 6.2 2.2 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein DUF913 PF06025.12 CDI84142.1 - 0.4 9.6 7.1 5.2 5.9 3.2 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) BORG_CEP PF14957.6 CDI84142.1 - 0.41 11.8 7.0 4.1 8.6 2.0 2.3 2 0 0 2 2 2 0 Cdc42 effector CPSF100_C PF13299.6 CDI84142.1 - 0.42 10.8 10.3 2.2 8.4 4.5 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3807 PF12720.7 CDI84142.1 - 0.42 10.9 20.4 2.3 8.5 11.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Hydin_ADK PF17213.3 CDI84142.1 - 0.44 10.8 12.6 7 6.9 7.3 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain MAT1 PF06391.13 CDI84142.1 - 0.64 9.8 23.4 1.6 8.5 13.4 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF4770 PF15994.5 CDI84142.1 - 0.7 10.1 13.3 1.7 8.9 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) MPM1 PF17234.2 CDI84142.1 - 0.72 10.1 16.6 1.4 9.1 5.9 2.3 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 ATAD4 PF15321.6 CDI84142.1 - 0.87 11.0 10.5 3.8 8.9 3.2 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Suf PF05843.14 CDI84142.1 - 0.94 9.4 18.2 2.1 8.3 6.4 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF1178 PF06676.11 CDI84142.1 - 1.1 9.7 18.8 0.1 13.0 2.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) PA26 PF04636.13 CDI84142.1 - 1.1 8.1 10.1 1.1 8.1 4.3 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) DUF719 PF05334.13 CDI84142.1 - 1.2 9.3 11.7 7.2 6.8 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) FHIPEP PF00771.20 CDI84142.1 - 1.5 7.2 9.7 3.4 6.0 0.4 2.1 2 0 0 2 2 2 0 FHIPEP family Rrp15p PF07890.12 CDI84142.1 - 1.5 9.2 18.5 0.64 10.4 7.2 2.4 2 0 0 2 2 2 0 Rrp15p DUF702 PF05142.12 CDI84142.1 - 1.5 9.3 16.7 5.7 7.4 2.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) LIM_bind PF01803.16 CDI84142.1 - 1.8 8.0 14.6 1.6 8.2 5.7 2.1 2 0 0 2 2 2 0 LIM-domain binding protein Thg1C PF14413.6 CDI84142.1 - 1.8 8.7 11.1 6.3 7.0 0.2 2.3 2 0 0 2 2 2 0 Thg1 C terminal domain RNA_pol_Rbc25 PF08292.12 CDI84142.1 - 1.9 8.7 12.0 2.1 8.6 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 PAT1 PF09770.9 CDI84142.1 - 1.9 6.6 22.5 0.44 8.7 2.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Spore_coat_CotO PF14153.6 CDI84142.1 - 2 8.3 25.0 3.7 7.4 5.4 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Neur_chan_memb PF02932.16 CDI84142.1 - 2 8.4 12.6 5.4 7.0 5.6 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PepSY_TM PF03929.16 CDI84142.1 - 2 8.0 5.8 11 5.6 0.8 2.3 2 0 0 2 2 2 0 PepSY-associated TM region TMEM51 PF15345.6 CDI84142.1 - 2.2 8.1 21.3 0.34 10.7 2.0 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 DUF3506 PF12014.8 CDI84142.1 - 2.2 8.3 5.1 2.2 8.3 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) Ndc1_Nup PF09531.10 CDI84142.1 - 2.2 6.8 10.8 1.8 7.1 2.7 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF2828 PF11443.8 CDI84142.1 - 2.4 6.1 10.7 2 6.4 4.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) PH_4 PF15404.6 CDI84142.1 - 2.4 7.9 11.2 3.6 7.3 3.6 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain UPF0524 PF15823.5 CDI84142.1 - 2.6 7.4 8.4 4.5 6.6 1.3 2.3 2 0 0 2 2 2 0 UPF0524 of C3orf70 DUF4518 PF15008.6 CDI84142.1 - 2.7 7.1 14.4 2 7.5 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) DUF3306 PF11748.8 CDI84142.1 - 2.7 8.9 25.0 0.72 10.7 4.0 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF3306) FAM60A PF15396.6 CDI84142.1 - 3.1 7.8 9.1 5 7.1 2.9 2.2 2 0 0 2 2 2 0 Protein Family FAM60A XRN_M PF17846.1 CDI84142.1 - 3.3 6.6 9.3 0.49 9.3 3.1 2.0 2 0 0 2 2 2 0 Xrn1 helical domain DUF2681 PF10883.8 CDI84142.1 - 3.8 8.0 27.1 2.1 8.8 5.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4746 PF15928.5 CDI84142.1 - 4.3 6.7 15.8 1 8.7 8.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) BAT2_N PF07001.11 CDI84142.1 - 4.6 7.7 19.0 4.1 7.8 7.8 2.2 2 0 0 2 2 2 0 BAT2 N-terminus Peroxin-13_N PF04088.13 CDI84142.1 - 4.8 7.5 8.1 16 5.8 2.6 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Fes1 PF08609.10 CDI84142.1 - 4.9 8.1 10.0 8.4 7.3 0.9 2.6 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 EIIBC-GUT_N PF03612.14 CDI84142.1 - 5 6.8 14.6 4.6 6.9 1.0 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3371 PF11851.8 CDI84142.1 - 5.6 8.1 17.8 5.9 8.0 5.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) TERB2 PF15101.6 CDI84142.1 - 5.7 6.9 23.0 5.4 7.0 10.5 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CTU2 PF10288.9 CDI84142.1 - 5.8 7.2 15.4 3.9 7.8 1.1 2.4 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 YABBY PF04690.13 CDI84142.1 - 5.9 7.4 9.0 17 5.9 2.8 2.2 2 0 0 2 2 2 0 YABBY protein UPF0560 PF10577.9 CDI84142.1 - 6.4 5.1 21.9 1.3 7.4 3.4 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 DUF4407 PF14362.6 CDI84142.1 - 6.5 6.0 14.4 10 5.4 7.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SprA-related PF12118.8 CDI84142.1 - 7.2 5.6 27.6 0.3 10.2 10.5 2.2 2 0 0 2 2 2 0 SprA-related family Ctr PF04145.15 CDI84142.1 - 7.4 7.2 10.7 8.7 7.0 2.0 2.3 2 0 0 2 2 2 0 Ctr copper transporter family NEMP PF10225.9 CDI84142.1 - 9.1 5.9 10.5 3.1 7.4 1.0 2.1 2 0 0 2 2 2 0 NEMP family LSM PF01423.22 CDI84144.1 - 6.1e-10 38.6 0.0 7.3e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDI84144.1 - 0.0027 17.8 0.2 0.0047 17.0 0.2 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain DUF2642 PF10842.8 CDI84144.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) LRR_6 PF13516.6 CDI84146.1 - 0.00076 19.3 6.4 13 6.1 0.0 6.1 6 0 0 6 6 6 1 Leucine Rich repeat RskA PF10099.9 CDI84146.1 - 0.0095 16.2 0.2 0.0095 16.2 0.2 9.9 5 3 2 7 7 7 3 Anti-sigma-K factor rskA EDR1 PF14381.6 CDI84146.1 - 0.023 14.4 0.0 0.083 12.6 0.0 1.9 1 1 1 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 LRR_1 PF00560.33 CDI84146.1 - 0.09 13.4 7.7 42 5.2 0.0 5.9 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 CDI84146.1 - 0.095 13.2 5.0 0.92 10.0 0.1 3.9 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) DUF4114 PF13448.6 CDI84146.1 - 7.5 7.4 6.4 37 5.2 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4114) HCV_env PF01539.17 CDI84147.1 - 0.025 14.3 0.2 0.037 13.7 0.2 1.3 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 TFIIA PF03153.13 CDI84147.1 - 0.059 13.4 27.4 0.077 13.0 27.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI84147.1 - 1.3 8.6 21.5 0.21 11.2 16.2 2.0 2 0 0 2 2 2 0 Spt20 family SR-25 PF10500.9 CDI84147.1 - 1.5 8.3 24.5 1 8.9 3.9 2.7 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Transglut_core3 PF13471.6 CDI84148.1 - 0.075 12.9 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF4618 PF15397.6 CDI84149.1 - 0.0046 16.4 5.0 0.006 16.0 5.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) TMPIT PF07851.13 CDI84149.1 - 0.04 13.2 2.0 0.044 13.0 2.0 1.0 1 0 0 1 1 1 0 TMPIT-like protein Fmp27_WPPW PF10359.9 CDI84149.1 - 0.061 12.2 6.1 0.065 12.1 6.1 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4407 PF14362.6 CDI84149.1 - 0.1 11.9 3.0 0.12 11.8 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FtsQ PF03799.15 CDI84149.1 - 0.2 12.5 1.7 0.22 12.3 1.7 1.1 1 0 0 1 1 1 0 Cell division protein FtsQ OmpH PF03938.14 CDI84149.1 - 1 9.7 8.4 1.3 9.3 8.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Csm1_N PF18504.1 CDI84149.1 - 1.5 9.2 10.9 13 6.2 10.9 2.0 1 1 0 1 1 1 0 Csm1 N-terminal domain DUF2076 PF09849.9 CDI84149.1 - 4.6 7.2 7.3 13 5.8 7.3 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Myb_DNA-binding PF00249.31 CDI84150.1 - 5.4e-13 48.9 0.0 6.4e-08 32.7 0.0 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDI84150.1 - 1.3e-08 34.9 0.0 0.00023 21.4 0.0 3.4 2 1 1 3 3 3 2 Myb-like DNA-binding domain Glyoxal_oxid_N PF07250.11 CDI84150.1 - 0.13 11.4 2.2 0.12 11.5 0.2 2.0 2 0 0 2 2 2 0 Glyoxal oxidase N-terminus SMAP PF15477.6 CDI84152.1 - 0.082 13.9 11.6 0.22 12.5 0.1 2.5 2 0 0 2 2 2 0 Small acidic protein family NifQ PF04891.12 CDI84152.1 - 0.14 12.5 0.3 0.14 12.5 0.3 2.5 2 1 1 3 3 3 0 NifQ Conotoxin PF02950.17 CDI84152.1 - 2.2 9.4 5.2 3.2 8.8 0.1 2.5 2 0 0 2 2 2 0 Conotoxin DUF4064 PF13273.6 CDI84152.1 - 6.3 7.1 8.3 12 6.3 1.3 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) p25-alpha PF05517.12 CDI84153.1 - 1.4e-39 135.8 4.2 1.6e-39 135.6 4.2 1.0 1 0 0 1 1 1 1 p25-alpha SurA_N PF09312.11 CDI84153.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 SurA N-terminal domain Pkinase_Tyr PF07714.17 CDI84154.1 - 0.0015 17.9 0.4 0.0028 17.0 0.2 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Golgin_A5 PF09787.9 CDI84154.1 - 0.36 10.3 25.1 0.62 9.5 25.1 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 PAT1 PF09770.9 CDI84154.1 - 0.44 8.8 21.4 0.62 8.3 21.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hydin_ADK PF17213.3 CDI84154.1 - 1.1 9.4 8.3 2.6 8.3 8.3 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Exonuc_VII_L PF02601.15 CDI84154.1 - 1.3 8.5 18.1 2.3 7.7 18.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_U57 PF05582.12 CDI84154.1 - 7.1 5.8 7.6 12 5.0 7.6 1.3 1 0 0 1 1 1 0 YabG peptidase U57 DSHCT PF08148.12 CDI84155.1 - 1.5e-27 96.2 0.4 1.5e-25 89.8 0.2 2.7 2 1 0 2 2 2 1 DSHCT (NUC185) domain TPR_2 PF07719.17 CDI84156.1 - 0.096 12.8 4.0 28 5.2 0.0 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PS_Dcarbxylase PF02666.15 CDI84158.1 - 2.4e-15 56.6 5.3 8.7e-11 41.7 0.0 2.7 1 1 1 2 2 2 2 Phosphatidylserine decarboxylase DNA_primase_lrg PF04104.14 CDI84159.1 - 3e-53 180.9 0.0 7.6e-46 156.7 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic and archaeal DNA primase, large subunit AF-4 PF05110.13 CDI84161.1 - 0.0013 17.0 5.0 0.0013 17.0 5.0 6.7 4 1 2 7 7 7 2 AF-4 proto-oncoprotein SR-25 PF10500.9 CDI84161.1 - 0.0024 17.5 4.3 0.0024 17.5 4.3 7.5 5 1 2 7 7 7 3 Nuclear RNA-splicing-associated protein AAA_5 PF07728.14 CDI84161.1 - 0.034 14.2 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Shadoo PF14999.6 CDI84161.1 - 0.17 12.0 0.1 0.17 12.0 0.1 9.4 5 3 4 9 9 9 0 Shadow of prion protein, neuroprotective PWI PF01480.17 CDI84162.1 - 1.2e-14 54.4 0.6 1.2e-14 54.4 0.6 2.1 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 CDI84162.1 - 3.6e-09 36.3 0.2 1.4e-08 34.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 CDI84162.1 - 0.0081 16.2 18.1 0.0087 16.1 0.0 4.4 3 1 1 4 4 4 2 Unstructured region C-term to UIM in Ataxin3 Phage_TAC_12 PF12363.8 CDI84162.1 - 0.11 12.9 0.5 5.3 7.5 0.0 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC RNA_pol_Rpb6 PF01192.22 CDI84163.1 - 1.6e-16 59.9 0.0 2.4e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF4549 PF15082.6 CDI84163.1 - 0.19 11.5 0.1 0.35 10.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) Med3 PF11593.8 CDI84166.1 - 0.0037 16.5 3.0 0.0037 16.5 3.0 15.0 8 6 4 13 13 13 1 Mediator complex subunit 3 fungal FAM199X PF15814.5 CDI84167.1 - 0.0058 15.7 4.5 0.0058 15.7 4.5 9.1 7 3 3 10 10 10 1 Protein family FAM199X Dynamitin PF04912.14 CDI84168.1 - 3.5e-05 23.3 13.6 3.5e-05 23.3 13.6 4.5 2 1 1 4 4 4 2 Dynamitin Caldesmon PF02029.15 CDI84168.1 - 0.00057 18.8 24.1 0.00057 18.8 24.1 4.0 2 1 0 2 2 2 1 Caldesmon C2 PF00168.30 CDI84170.1 - 1.4e-25 89.5 0.2 1.3e-07 31.8 0.0 4.5 4 0 0 4 4 4 4 C2 domain ERM PF00769.19 CDI84171.1 - 0.17 11.6 14.7 0.42 10.4 14.7 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ADIP PF11559.8 CDI84171.1 - 1.7 8.7 12.9 4.4 7.4 12.9 1.7 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FapA PF03961.13 CDI84176.1 - 0.047 12.3 10.5 0.061 11.9 10.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 CDI84176.1 - 3.2 7.8 8.8 2.5 8.2 6.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 CDI84176.1 - 4.3 6.3 22.1 12 4.9 22.1 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 CDI84176.1 - 9.9 5.3 11.3 15 4.7 10.9 1.4 1 1 0 1 1 1 0 TMPIT-like protein Acetyltransf_1 PF00583.25 CDI84177.1 - 5.1e-10 39.6 0.0 7.9e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDI84177.1 - 1e-05 25.5 0.1 1.6e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDI84177.1 - 2e-05 24.9 0.0 3.1e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDI84177.1 - 0.00063 19.7 0.1 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDI84177.1 - 0.016 15.3 0.1 0.039 14.0 0.0 1.6 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDI84177.1 - 0.018 15.2 0.0 0.027 14.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Med3 PF11593.8 CDI84177.1 - 0.73 9.0 11.6 1 8.5 11.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Secretin_N_2 PF07655.13 CDI84178.1 - 5.3 7.7 16.1 0.77 10.3 12.1 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain SR-25 PF10500.9 CDI84180.1 - 0.054 13.1 37.1 0.064 12.9 6.6 3.0 1 1 2 3 3 3 0 Nuclear RNA-splicing-associated protein CLTH PF10607.9 CDI84181.1 - 8.5e-11 41.9 0.0 2.4e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain RskA PF10099.9 CDI84181.1 - 0.0041 17.4 6.9 0.0041 17.4 6.9 28.0 4 4 15 19 19 19 4 Anti-sigma-K factor rskA TFIIA PF03153.13 CDI84182.1 - 0.35 10.8 25.5 0.48 10.4 25.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit W2 PF02020.18 CDI84184.1 - 7.2e-15 54.9 0.2 1e-14 54.4 0.2 1.2 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Utp13 PF08625.11 CDI84187.1 - 3.8e-13 49.6 3.9 3.8e-13 49.6 3.9 2.6 2 2 0 2 2 2 1 Utp13 specific WD40 associated domain FANCI_HD1 PF14679.6 CDI84187.1 - 0.073 13.0 3.7 1.5 8.8 2.0 3.0 2 0 0 2 2 2 0 FANCI helical domain 1 RR_TM4-6 PF06459.12 CDI84187.1 - 0.17 11.7 21.8 0.3 10.9 10.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 CDI84187.1 - 4.3 7.4 23.2 2.2 8.4 2.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4746 PF15928.5 CDI84187.1 - 4.5 6.6 12.0 3.9 6.8 4.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Afi1 PF07792.12 CDI84187.1 - 5.8 7.4 19.4 4.3 7.8 8.0 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 CDI84187.1 - 8.7 5.0 24.3 3.6 6.2 14.0 2.2 2 0 0 2 2 2 0 Presenilin DUF2052 PF09747.9 CDI84188.1 - 3.2 7.8 47.2 3.9 7.6 47.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) WD40 PF00400.32 CDI84189.1 - 2.6e-10 40.7 0.6 0.0078 17.0 0.0 6.2 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDI84189.1 - 0.0062 16.8 0.0 0.13 12.6 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SUIM_assoc PF16619.5 CDI84189.1 - 0.013 15.6 0.2 0.013 15.6 0.2 6.9 6 1 1 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 IML1 PF12257.8 CDI84189.1 - 0.31 10.1 2.7 0.23 10.5 0.8 1.7 2 0 0 2 2 2 0 Vacuolar membrane-associated protein Iml1 Sec16 PF12932.7 CDI84189.1 - 8.6 7.0 8.6 0.38 11.3 0.7 2.9 3 1 1 4 4 4 0 Vesicle coat trafficking protein Sec16 mid-region RRM_1 PF00076.22 CDI84190.1 - 4e-07 29.8 0.0 7.2e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDI84190.1 - 0.00086 19.4 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM PF05172.13 CDI84190.1 - 0.022 14.7 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SNF2_N PF00176.23 CDI84191.1 - 1e-12 47.5 1.2 1.3e-11 43.9 0.1 1.9 1 1 1 2 2 2 2 SNF2 family N-terminal domain DEAD PF00270.29 CDI84191.1 - 0.053 13.3 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase Ureide_permease PF07168.11 CDI84195.1 - 2.9 6.6 3.6 0.86 8.3 0.1 1.8 2 0 0 2 2 2 0 Ureide permease Fimbrial_CS1 PF04449.12 CDI84199.1 - 0.079 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 CS1 type fimbrial major subunit 7TMR-HDED PF07697.11 CDI84199.1 - 3.4 7.7 7.2 30 4.7 7.2 2.0 1 1 0 1 1 1 0 7TM-HD extracellular RNA_pol_Rpb1_2 PF00623.20 CDI84200.1 - 2.1e-55 187.4 0.0 2.2e-37 128.9 0.0 2.6 2 0 0 2 2 2 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CDI84200.1 - 3.5e-24 85.5 0.0 6e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 CDI84200.1 - 5.7e-15 55.4 1.6 1.4e-12 47.6 0.0 3.9 2 2 2 4 4 4 1 RNA polymerase Rpb1, domain 1 SUIM_assoc PF16619.5 CDI84200.1 - 1.9e-05 24.6 32.6 0.76 9.9 0.2 5.2 4 0 0 4 4 4 4 Unstructured region C-term to UIM in Ataxin3 SNF2_N PF00176.23 CDI84201.1 - 5.6e-34 117.4 0.0 5.6e-34 117.4 0.0 3.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 CDI84201.1 - 8.1e-14 51.5 0.0 1.8e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 CDI84201.1 - 1.9e-06 28.2 0.1 2e-05 24.9 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Adap_comp_sub PF00928.21 CDI84202.1 - 3.2e-86 289.0 0.0 4e-86 288.7 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDI84202.1 - 3.1e-05 24.0 0.1 5.8e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TFIIA PF03153.13 CDI84203.1 - 0.27 11.2 12.9 0.6 10.1 4.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI84203.1 - 2.2 7.8 17.9 2.7 7.6 8.3 2.1 2 0 0 2 2 2 0 Spt20 family Mito_carr PF00153.27 CDI84204.1 - 6.8e-30 102.9 10.5 6.1e-10 38.9 0.0 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Kinase-like PF14531.6 CDI84205.1 - 2.5e-14 53.3 0.0 3.8e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 CDI84205.1 - 0.0029 17.0 0.0 0.0077 15.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84205.1 - 0.2 10.9 0.0 0.35 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF4744 PF15918.5 CDI84205.1 - 0.46 11.4 29.2 0.6 11.0 12.6 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4744) RabGAP-TBC PF00566.18 CDI84206.1 - 1.8e-29 103.0 5.4 1.4e-28 100.1 0.2 3.1 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Phycoerythr_ab PF02972.14 CDI84206.1 - 0.052 13.4 0.5 0.15 11.9 0.5 1.7 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain Com_YlbF PF06133.11 CDI84206.1 - 3.6 8.2 9.1 5.4 7.7 5.4 2.6 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Beta-lactamase PF00144.24 CDI84207.1 - 2.9e-42 145.1 0.3 1.8e-36 126.0 0.0 3.4 3 1 0 3 3 3 3 Beta-lactamase ABC1 PF03109.16 CDI84207.1 - 6.2e-24 84.4 0.0 1.3e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.11 CDI84207.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) CCDC142 PF14923.6 CDI84209.1 - 0.1 11.3 0.1 0.11 11.2 0.1 1.0 1 0 0 1 1 1 0 Coiled-coil protein 142 MFS_1 PF07690.16 CDI84210.1 - 3.3e-15 55.9 57.3 6.9e-11 41.7 37.1 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 CDI84211.1 - 1.3e-20 73.8 0.0 4.8e-20 72.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI84211.1 - 4.6e-19 68.8 0.0 7.1e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 CDI84211.1 - 4.4e-06 26.2 0.0 2.1e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI84211.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CDI84211.1 - 0.1 12.2 0.0 0.26 10.9 0.0 1.7 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CDI84211.1 - 0.14 12.1 0.2 0.35 10.7 0.1 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family KH_1 PF00013.29 CDI84212.1 - 7.8e-42 141.0 0.0 1.1e-11 44.3 0.2 6.1 6 0 0 6 6 6 5 KH domain KH_2 PF07650.17 CDI84212.1 - 0.057 13.3 0.0 3.4 7.6 0.0 2.9 3 0 0 3 3 3 0 KH domain DnaJ PF00226.31 CDI84213.1 - 1.1e-11 44.6 0.7 3.3e-11 43.2 0.1 2.1 3 0 0 3 3 3 1 DnaJ domain GTP_EFTU PF00009.27 CDI84214.1 - 1.8e-32 112.5 0.0 2.1e-23 82.9 0.0 2.7 1 1 0 2 2 2 2 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CDI84214.1 - 1.9e-31 109.2 0.7 1.9e-31 109.2 0.7 4.4 4 0 0 4 4 4 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus SR-25 PF10500.9 CDI84214.1 - 7e-05 22.5 23.6 0.04 13.5 13.3 3.1 3 0 0 3 3 3 2 Nuclear RNA-splicing-associated protein RskA PF10099.9 CDI84214.1 - 0.00054 20.3 24.4 0.46 10.8 1.8 4.4 4 0 0 4 4 4 3 Anti-sigma-K factor rskA Shadoo PF14999.6 CDI84214.1 - 0.0024 18.0 2.0 0.0024 18.0 2.0 3.8 4 0 0 4 4 4 2 Shadow of prion protein, neuroprotective MMR_HSR1 PF01926.23 CDI84214.1 - 0.014 15.4 0.0 0.072 13.2 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zip PF02535.22 CDI84214.1 - 0.055 12.7 0.0 0.055 12.7 0.0 2.7 3 0 0 3 3 3 0 ZIP Zinc transporter Roc PF08477.13 CDI84214.1 - 0.11 12.7 0.0 7.8 6.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Apt1 PF10351.9 CDI84214.1 - 0.18 10.6 15.9 0.19 10.6 1.5 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain K_channel_TID PF07941.11 CDI84214.1 - 0.32 11.5 51.7 0.087 13.3 10.0 4.8 4 0 0 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain Miga PF10265.9 CDI84214.1 - 4.2 6.2 9.7 1.2 8.0 1.7 2.3 2 0 0 2 2 2 0 Mitoguardin DUF4228 PF14009.6 CDI84214.1 - 5 7.5 17.5 4.9 7.5 0.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4228) RCC1 PF00415.18 CDI84215.1 - 7.6e-25 87.3 12.2 6.9e-08 33.0 0.3 8.2 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI84215.1 - 7e-19 67.1 34.3 3.8e-07 29.7 3.0 6.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat PIG-S PF10510.9 CDI84217.1 - 3.5e-11 42.6 0.0 4.9e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein DUF3712 PF12505.8 CDI84218.1 - 2.2e-27 95.8 3.9 7.4e-13 48.9 0.0 8.0 7 0 0 7 7 7 5 Protein of unknown function (DUF3712) Velvet PF11754.8 CDI84218.1 - 0.00043 20.3 37.3 0.14 12.1 2.7 6.5 7 1 0 7 7 7 5 Velvet factor EPL1 PF10513.9 CDI84218.1 - 0.12 12.8 45.2 0.28 11.6 3.9 6.3 6 0 0 6 6 6 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 CDI84218.1 - 4 7.4 31.3 0.73 9.8 0.7 5.0 5 0 0 5 5 5 0 Neurotransmitter-gated ion-channel transmembrane region FYVE PF01363.21 CDI84219.1 - 1.5e-14 53.8 13.3 1.5e-14 53.8 13.3 2.3 2 0 0 2 2 2 1 FYVE zinc finger PIP5K PF01504.18 CDI84219.1 - 1.1e-10 41.2 15.7 1e-05 24.9 0.1 4.8 5 1 1 6 6 6 3 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 CDI84219.1 - 0.00074 18.3 0.0 0.0012 17.6 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family OmdA PF13376.6 CDI84220.1 - 0.026 14.5 0.2 0.081 12.9 0.2 1.8 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated COPI_assoc PF08507.10 CDI84223.1 - 2.3e-11 43.8 4.8 3.1e-11 43.4 4.8 1.1 1 0 0 1 1 1 1 COPI associated protein Peptidase_C65 PF10275.9 CDI84225.1 - 2.3e-53 181.2 0.0 2.9e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 CDI84225.1 - 0.0005 20.6 0.0 0.017 15.6 0.0 2.3 1 1 0 1 1 1 1 OTU-like cysteine protease TFIIA PF03153.13 CDI84225.1 - 0.0031 17.6 3.7 0.0035 17.4 3.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF935 PF06074.12 CDI84225.1 - 0.025 13.3 1.6 0.035 12.8 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF935) DUF3336 PF11815.8 CDI84225.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) Ribosomal_60s PF00428.19 CDI84225.1 - 2.3 8.9 12.6 4.9 7.8 9.8 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3446 PF11928.8 CDI84225.1 - 5.7 7.3 26.9 0.76 10.1 2.0 3.1 2 0 0 2 2 2 0 Early growth response N-terminal domain mTERF PF02536.14 CDI84226.1 - 8.6e-13 47.9 0.1 1.4e-10 40.6 0.0 2.3 2 0 0 2 2 2 2 mTERF RskA PF10099.9 CDI84226.1 - 0.0035 17.6 0.7 0.0035 17.6 0.7 5.9 2 1 3 5 5 5 1 Anti-sigma-K factor rskA DUF4667 PF15700.5 CDI84226.1 - 0.31 11.1 10.2 0.25 11.4 4.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) IF-2B PF01008.17 CDI84227.1 - 6.7e-15 55.0 5.6 1e-09 38.1 0.0 3.2 2 1 0 3 3 3 2 Initiation factor 2 subunit family Spt20 PF12090.8 CDI84227.1 - 4e-05 23.3 1.0 4e-05 23.3 1.0 3.4 2 1 0 2 2 2 1 Spt20 family SUIM_assoc PF16619.5 CDI84227.1 - 0.00012 22.0 1.2 0.00012 22.0 1.2 7.1 3 2 1 4 4 4 1 Unstructured region C-term to UIM in Ataxin3 Lon_2 PF13337.6 CDI84227.1 - 0.0027 16.3 0.0 0.0027 16.3 0.0 1.9 2 0 0 2 2 2 1 Putative ATP-dependent Lon protease UPF0524 PF15823.5 CDI84227.1 - 0.2 11.1 0.1 0.2 11.1 0.1 3.9 3 1 0 3 3 3 0 UPF0524 of C3orf70 DUF4471 PF14740.6 CDI84227.1 - 0.32 10.2 10.8 1.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Peptidase_S49_N PF08496.10 CDI84227.1 - 0.89 9.6 0.0 0.89 9.6 0.0 2.9 2 1 1 3 3 3 0 Peptidase family S49 N-terminal ARS2 PF04959.13 CDI84228.1 - 6.1e-10 39.8 0.0 1.1e-09 38.9 0.0 1.4 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 CDI84228.1 - 0.00082 19.1 0.3 0.0021 17.8 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) Stc1 PF12898.7 CDI84228.1 - 0.093 13.3 0.7 0.093 13.3 0.7 1.7 1 1 0 1 1 1 0 Stc1 domain zf-C2H2 PF00096.26 CDI84228.1 - 1 10.0 6.0 3.1 8.4 6.0 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type PRP38_assoc PF12871.7 CDI84228.1 - 1.4 9.5 19.7 0.55 10.9 13.3 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 PF13054.6 CDI84228.1 - 2 8.4 6.4 3.8 7.5 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Pkinase PF00069.25 CDI84231.1 - 2.2e-14 53.5 0.0 2.2e-14 53.5 0.0 3.6 2 2 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84231.1 - 6.3e-07 28.9 0.0 6.3e-07 28.9 0.0 2.6 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI84231.1 - 3.7 6.2 0.0 3.7 6.2 0.0 3.3 2 1 1 3 3 3 0 Fungal protein kinase Thioredoxin PF00085.20 CDI84233.1 - 1.1e-26 92.8 0.0 6.8e-14 51.7 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CDI84233.1 - 5.1e-07 29.8 0.0 2.6e-06 27.5 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Dehydrin PF00257.19 CDI84233.1 - 0.0055 17.3 0.4 0.0055 17.3 0.4 4.7 4 1 0 4 4 4 1 Dehydrin tRNA-synt_1 PF00133.22 CDI84236.1 - 4.4e-102 342.3 0.1 5.3e-73 246.3 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 CDI84236.1 - 3.5e-10 39.7 0.0 8.8e-08 31.9 0.0 2.4 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 CDI84236.1 - 1e-09 37.6 0.0 6.5e-09 35.0 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) DUF3201 PF11447.8 CDI84236.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) tRNA-synt_1c PF00749.21 CDI84236.1 - 0.034 13.1 0.0 0.058 12.3 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Proteasome_A_N PF10584.9 CDI84236.1 - 0.06 13.0 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature T2SSI PF02501.17 CDI84236.1 - 0.15 12.3 0.2 0.15 12.3 0.2 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein I 4HBT PF03061.22 CDI84237.1 - 0.00049 20.4 6.1 0.018 15.4 0.1 3.3 4 0 0 4 4 4 2 Thioesterase superfamily Miga PF10265.9 CDI84237.1 - 0.11 11.4 2.8 0.23 10.4 2.8 1.4 1 0 0 1 1 1 0 Mitoguardin Pkinase PF00069.25 CDI84238.1 - 1.6e-15 57.2 0.0 1.8e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84238.1 - 0.24 10.7 0.0 0.43 9.8 0.0 1.6 1 1 0 1 1 1 0 Protein tyrosine kinase AAA_16 PF13191.6 CDI84239.1 - 6.1e-05 23.5 0.4 6.1e-05 23.5 0.4 2.8 3 0 0 3 3 3 1 AAA ATPase domain ATPase_2 PF01637.18 CDI84239.1 - 0.011 15.6 0.0 0.09 12.7 0.0 2.4 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CDI84239.1 - 0.015 15.5 1.8 0.26 11.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 CDI84239.1 - 0.02 15.2 0.2 3 8.2 0.0 2.8 2 2 1 3 3 3 0 AAA domain Spt20 PF12090.8 CDI84239.1 - 1.4 8.5 7.6 2.9 7.4 7.6 1.5 1 0 0 1 1 1 0 Spt20 family FTZ PF03867.14 CDI84239.1 - 8.6 5.8 10.9 35 3.8 0.0 2.2 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Metallophos PF00149.28 CDI84240.1 - 8.4e-27 95.0 0.0 1.1e-26 94.6 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDI84240.1 - 0.022 15.2 0.1 0.046 14.2 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 CDI84240.1 - 0.031 14.5 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain PAP_central PF04928.17 CDI84245.1 - 2.2e-49 167.7 0.0 5.7e-28 97.6 0.0 2.3 1 1 1 2 2 2 2 Poly(A) polymerase central domain NTP_transf_2 PF01909.23 CDI84245.1 - 1.2e-10 41.5 0.0 2.1e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_RNA-bind PF04926.15 CDI84245.1 - 3.1e-09 36.7 3.0 4.3e-08 33.0 0.4 2.7 3 0 0 3 3 3 1 Poly(A) polymerase predicted RNA binding domain Spt20 PF12090.8 CDI84245.1 - 3 7.4 8.1 5.3 6.6 8.1 1.3 1 0 0 1 1 1 0 Spt20 family Spt20 PF12090.8 CDI84246.1 - 0.00011 21.9 9.2 0.00011 21.9 9.2 2.1 2 0 0 2 2 2 1 Spt20 family RskA PF10099.9 CDI84246.1 - 0.00029 21.2 10.2 0.00029 21.2 10.2 2.1 2 0 0 2 2 2 1 Anti-sigma-K factor rskA Suf PF05843.14 CDI84246.1 - 0.065 13.2 30.4 0.61 10.0 1.5 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Zip PF02535.22 CDI84246.1 - 0.092 12.0 13.9 0.053 12.7 9.2 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4834 PF16118.5 CDI84246.1 - 0.25 12.3 32.7 1 10.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Trp_oprn_chp PF09534.10 CDI84246.1 - 0.26 11.0 4.4 0.27 11.0 0.2 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF1115 PF06544.12 CDI84246.1 - 0.29 11.2 0.2 0.29 11.2 0.2 2.6 2 1 0 2 2 1 0 Protein of unknown function (DUF1115) Spore_coat_CotO PF14153.6 CDI84246.1 - 0.79 9.6 31.1 0.97 9.3 14.6 2.3 2 0 0 2 2 2 0 Spore coat protein CotO SprA-related PF12118.8 CDI84246.1 - 1.7 7.7 50.1 0.044 12.9 29.6 2.0 2 0 0 2 2 2 0 SprA-related family RAP1 PF07218.11 CDI84246.1 - 4.2 5.5 9.6 5 5.3 9.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SPX PF03105.19 CDI84246.1 - 4.4 7.1 24.7 9.9 6.0 24.7 1.5 1 1 0 1 1 1 0 SPX domain SMYLE_N PF18615.1 CDI84246.1 - 4.5 6.7 28.4 6.9 6.1 1.1 2.0 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SPX PF03105.19 CDI84248.1 - 4.6 7.1 32.7 1.8e+04 -10.7 32.7 3.1 1 1 0 1 1 1 0 SPX domain RR_TM4-6 PF06459.12 CDI84249.1 - 2.8 7.7 5.9 4.4 7.1 5.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 CDI84249.1 - 7.1 4.6 7.4 8.9 4.3 7.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med7 PF05983.11 CDI84251.1 - 2.5e-15 57.0 26.7 1e-12 48.5 26.7 2.1 1 1 0 1 1 1 1 MED7 protein DUF4175 PF13779.6 CDI84251.1 - 0.00029 18.9 35.3 0.00045 18.3 35.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) Raftlin PF15250.6 CDI84251.1 - 0.0043 15.9 10.8 0.0043 15.9 10.8 1.5 2 0 0 2 2 2 1 Raftlin CDC45 PF02724.14 CDI84251.1 - 0.39 9.0 20.3 0.63 8.3 20.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 CDI84251.1 - 0.69 8.4 24.1 0.43 9.1 16.3 2.2 2 0 0 2 2 2 0 Macoilin family CAML PF14963.6 CDI84251.1 - 0.79 9.8 7.1 1.4 8.9 7.1 1.5 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SKA1 PF07160.12 CDI84251.1 - 1.8 8.4 35.4 1.8 8.4 0.6 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 SPX PF03105.19 CDI84251.1 - 3.4 7.5 21.5 0.3 10.9 15.1 1.9 2 0 0 2 2 2 0 SPX domain MDM10 PF12519.8 CDI84251.1 - 3.9 6.2 18.4 6.6 5.5 18.4 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Ribosomal_60s PF00428.19 CDI84251.1 - 5.6 7.6 11.7 12 6.6 11.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Lin-8 PF03353.15 CDI84251.1 - 6.8 6.2 32.2 0.63 9.6 26.2 1.9 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist MINDY_DUB PF04424.13 CDI84252.1 - 1.5e-19 70.1 0.3 1.5e-19 70.1 0.3 4.2 3 3 0 3 3 3 1 MINDY deubiquitinase SUIM_assoc PF16619.5 CDI84252.1 - 3.2e-07 30.3 3.2 0.00039 20.4 0.1 11.5 5 3 1 6 6 6 2 Unstructured region C-term to UIM in Ataxin3 Dehydrin PF00257.19 CDI84252.1 - 0.0035 17.9 6.7 0.0035 17.9 6.7 10.9 5 2 1 7 7 7 1 Dehydrin Ldh_1_N PF00056.23 CDI84253.1 - 2.4e-37 128.2 1.2 4.2e-37 127.4 0.4 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDI84253.1 - 1.4e-28 99.9 0.0 2.1e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 CDI84253.1 - 8.5e-05 22.2 0.6 0.0036 16.9 0.0 2.6 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase 3Beta_HSD PF01073.19 CDI84253.1 - 0.035 13.1 0.1 0.052 12.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family IMP2_N PF18590.1 CDI84254.1 - 3.7e-19 69.0 0.0 7.2e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain RNA_pol_Rpb2_6 PF00562.28 CDI84257.1 - 1.5e-47 162.5 0.0 1.8e-47 162.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 CDI84257.1 - 5.8e-34 116.4 0.5 8.3e-34 115.9 0.5 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 zf-C2H2_6 PF13912.6 CDI84257.1 - 2 8.5 6.6 13 5.9 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger TBP PF00352.21 CDI84258.1 - 4.4e-11 42.6 0.0 2.2e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) HCV_NS2 PF01538.18 CDI84258.1 - 0.042 13.5 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 DUF1126 PF06565.12 CDI84259.1 - 2.8e-48 162.1 2.9 2.4e-24 85.2 0.0 3.4 3 0 0 3 3 3 3 DUF1126 PH-like domain Actino_peptide PF14408.6 CDI84260.1 - 4.5 7.5 10.1 8.1 6.6 0.6 3.0 3 1 0 3 3 3 0 Ribosomally synthesised peptide in actinomycetes AAA PF00004.29 CDI84262.1 - 1.5e-40 138.7 0.0 2.2e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI84262.1 - 1.7e-05 25.1 0.0 0.0082 16.4 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 CDI84262.1 - 2.3e-05 24.4 0.1 0.00014 21.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDI84262.1 - 9.5e-05 22.8 0.2 0.0015 19.0 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDI84262.1 - 0.00088 19.0 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDI84262.1 - 0.0012 18.9 0.1 0.0036 17.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 CDI84262.1 - 0.012 15.2 0.0 0.033 13.7 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 CDI84262.1 - 0.012 15.8 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDI84262.1 - 0.017 15.7 0.0 0.028 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDI84262.1 - 0.026 14.2 0.1 0.077 12.7 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDI84262.1 - 0.027 14.6 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDI84262.1 - 0.027 13.6 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 CDI84262.1 - 0.051 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 CDI84262.1 - 0.054 12.6 0.0 0.13 11.3 0.0 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_11 PF13086.6 CDI84262.1 - 0.058 13.2 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CDI84262.1 - 0.078 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activat PF00158.26 CDI84262.1 - 0.14 11.9 0.0 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 CDI84262.1 - 0.18 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 CDI84262.1 - 0.2 12.1 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TFIIA PF03153.13 CDI84263.1 - 1.5 8.7 13.1 2.4 8.1 13.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1501 PF07394.12 CDI84263.1 - 1.6 7.7 5.5 2.7 7.0 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DLIC PF05783.11 CDI84263.1 - 4.8 5.9 9.6 6.3 5.5 3.9 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) Metallophos PF00149.28 CDI84264.1 - 1.8e-12 48.2 0.0 3.8e-12 47.1 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PGA_cap PF09587.10 CDI84264.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap SRA1 PF07304.11 CDI84266.1 - 0.067 13.0 0.1 0.067 13.0 0.1 3.0 3 0 0 3 3 3 0 Steroid receptor RNA activator (SRA1) Ribosomal_L3 PF00297.22 CDI84268.1 - 3e-10 39.6 4.3 2.6e-08 33.3 3.1 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Macoilin PF09726.9 CDI84268.1 - 0.0027 16.4 2.5 0.0031 16.2 2.5 1.2 1 0 0 1 1 1 1 Macoilin family SPX PF03105.19 CDI84268.1 - 0.0052 16.8 1.7 0.0068 16.4 1.7 1.3 1 0 0 1 1 1 1 SPX domain Apt1 PF10351.9 CDI84268.1 - 0.019 13.9 1.5 0.021 13.7 1.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Menin PF05053.13 CDI84268.1 - 0.27 9.6 0.9 0.35 9.2 0.9 1.1 1 0 0 1 1 1 0 Menin BatA PF07584.11 CDI84268.1 - 0.79 10.1 7.0 9.3 6.7 7.1 2.5 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF1180 PF06679.12 CDI84268.1 - 1.2 9.5 3.9 28 5.1 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) RNA_pol_N PF01194.17 CDI84270.1 - 2e-32 111.3 0.4 2.4e-32 111.0 0.4 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Thioredoxin PF00085.20 CDI84271.1 - 6.9e-29 99.9 0.4 7.7e-29 99.7 0.4 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDI84271.1 - 2.5e-05 24.7 0.5 0.00073 20.0 0.5 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.24 CDI84271.1 - 0.0001 22.4 0.1 0.00014 22.0 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_8 PF13905.6 CDI84271.1 - 0.00015 22.0 0.1 0.00034 20.9 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 CDI84271.1 - 0.0008 19.2 0.1 0.00083 19.1 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin KaiB PF07689.12 CDI84271.1 - 0.0012 18.5 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 KaiB domain OST3_OST6 PF04756.13 CDI84271.1 - 0.021 14.2 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CDI84271.1 - 0.023 14.9 0.1 0.031 14.5 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 CDI84271.1 - 0.036 14.0 0.1 0.044 13.7 0.1 1.2 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 CDI84271.1 - 0.048 13.4 0.7 0.23 11.1 0.2 1.9 1 1 0 2 2 2 0 Redoxin CPW_WPC PF09717.10 CDI84275.1 - 0.19 12.7 0.6 1.8 9.6 0.2 2.2 2 0 0 2 2 2 0 Plasmodium falciparum domain of unknown function (CPW_WPC) Zip PF02535.22 CDI84276.1 - 2.6e-32 112.4 6.3 5.5e-26 91.6 4.3 3.4 3 1 0 3 3 3 2 ZIP Zinc transporter PA26 PF04636.13 CDI84276.1 - 0.01 14.8 0.8 0.082 11.8 0.0 2.1 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) EphA2_TM PF14575.6 CDI84276.1 - 0.028 15.3 1.5 1.2 10.1 0.0 3.4 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 CDI84276.1 - 0.17 12.2 0.8 4.2 7.7 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) DUF2722 PF10846.8 CDI84276.1 - 2.6 6.9 12.1 0.25 10.3 0.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84276.1 - 8.4 5.9 21.4 0.74 9.4 4.7 3.3 3 0 0 3 3 3 0 Spt20 family AstB PF04996.12 CDI84277.1 - 0.035 12.8 2.3 0.053 12.2 2.3 1.2 1 0 0 1 1 1 0 Succinylarginine dihydrolase SUIM_assoc PF16619.5 CDI84277.1 - 0.12 12.4 8.1 0.45 10.6 8.1 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI84277.1 - 0.26 10.9 8.1 0.41 10.2 8.1 1.3 1 0 0 1 1 1 0 Spt20 family SR-25 PF10500.9 CDI84277.1 - 2.5 7.7 21.8 4.4 6.8 21.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RXT2_N PF08595.11 CDI84278.1 - 0.52 10.3 11.1 0.64 10.0 11.1 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal TRAP_alpha PF03896.16 CDI84278.1 - 4.2 6.5 14.2 4.9 6.3 14.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PBP1_TM PF14812.6 CDI84278.1 - 4.4 7.7 18.3 39 4.7 18.3 2.2 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 CDI84278.1 - 6.9 6.3 20.9 7.9 6.1 20.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 CDI84278.1 - 8.4 4.5 24.8 9.7 4.3 24.8 1.0 1 0 0 1 1 1 0 Nop14-like family DJ-1_PfpI PF01965.24 CDI84279.1 - 3.9e-39 134.1 0.0 5e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 CDI84279.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Upf2 PF04050.14 CDI84280.1 - 0.00039 21.1 14.2 0.00039 21.1 14.2 4.6 2 2 1 3 3 3 2 Up-frameshift suppressor 2 Hamartin PF04388.12 CDI84280.1 - 0.47 9.1 41.2 0.74 8.4 41.2 1.3 1 0 0 1 1 1 0 Hamartin protein RskA PF10099.9 CDI84280.1 - 1.6 9.0 46.0 0.056 13.7 13.2 2.7 1 1 0 2 2 2 0 Anti-sigma-K factor rskA RskA PF10099.9 CDI84281.1 - 0.71 10.1 0.0 0.71 10.1 0.0 22.6 7 3 9 16 16 16 0 Anti-sigma-K factor rskA SPX PF03105.19 CDI84282.1 - 0.026 14.5 6.0 0.029 14.3 6.0 1.0 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 CDI84282.1 - 0.031 13.1 6.9 0.031 13.1 6.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Sec3_C PF09763.9 CDI84282.1 - 0.16 10.3 1.4 0.15 10.4 1.4 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 Tmemb_cc2 PF10267.9 CDI84282.1 - 0.34 10.0 3.7 0.32 10.1 3.7 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein RIFIN PF02009.16 CDI84282.1 - 4.2 7.2 7.8 6.4 6.6 7.8 1.3 1 1 0 1 1 1 0 Rifin IMP2_N PF18590.1 CDI84285.1 - 1.9e-22 79.6 0.2 2.8e-22 79.1 0.2 1.3 1 0 0 1 1 1 1 Immune Mapped Protein 2 (IMP2) N-terminal domain RRM_1 PF00076.22 CDI84286.1 - 8e-14 51.2 0.0 5.9e-13 48.4 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1768 PF08719.11 CDI84286.1 - 1.1e-13 51.7 0.0 2e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) FHA PF00498.26 CDI84286.1 - 3e-10 40.3 0.0 1.3e-09 38.3 0.0 2.1 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 CDI84286.1 - 6.4e-07 29.6 0.0 1.8e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RRM_7 PF16367.5 CDI84286.1 - 0.0066 16.5 0.0 0.022 14.9 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM PF05172.13 CDI84286.1 - 0.012 15.6 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif WD40 PF00400.32 CDI84288.1 - 1.8e-18 66.6 10.8 0.00024 21.8 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Cwf_Cwc_15 PF04889.12 CDI84288.1 - 1.2 8.8 5.7 1.7 8.3 5.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sugarporin_N PF11471.8 CDI84289.1 - 2.9 7.9 8.9 1.6 8.8 2.9 3.2 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Ribosomal_S24e PF01282.19 CDI84290.1 - 1.7e-25 88.8 0.0 2.9e-25 88.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e AAA_25 PF13481.6 CDI84290.1 - 0.022 14.3 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain P120R PF08062.11 CDI84290.1 - 1.5 9.2 0.1 1.5 9.2 0.1 2.8 2 0 0 2 2 2 0 P120R (NUC006) repeat Ribosomal_L1 PF00687.21 CDI84291.1 - 2.1e-41 141.9 4.1 2.6e-41 141.6 4.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3730 PF12530.8 CDI84293.1 - 0.0026 17.4 0.2 0.0055 16.3 0.0 1.6 2 1 0 2 2 2 1 Protein of unknown function (DUF3730) HUN PF08729.10 CDI84293.1 - 0.01 15.9 2.7 0.026 14.5 2.7 1.7 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Tic110 PF16940.5 CDI84293.1 - 3.2 6.1 8.2 4.7 5.6 8.2 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter SUIM_assoc PF16619.5 CDI84300.1 - 1.2 9.2 23.4 0.54 10.4 1.0 4.7 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 RRM_1 PF00076.22 CDI84302.1 - 0.00031 20.5 0.0 0.0005 19.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CobT PF06213.12 CDI84303.1 - 0.00081 18.9 30.4 0.021 14.3 21.1 2.2 2 0 0 2 2 2 2 Cobalamin biosynthesis protein CobT Afi1 PF07792.12 CDI84303.1 - 0.0013 19.2 13.0 0.0044 17.5 5.2 2.1 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4611 PF15387.6 CDI84303.1 - 0.0014 18.8 1.4 0.0014 18.8 1.4 2.8 2 1 0 2 2 1 1 Domain of unknown function (DUF4611) FmiP_Thoc5 PF09766.9 CDI84303.1 - 0.0027 17.0 13.2 0.0027 17.0 13.2 2.1 2 0 0 2 2 2 1 Fms-interacting protein/Thoc5 Pex26 PF07163.12 CDI84303.1 - 0.0036 16.7 22.6 0.15 11.4 10.3 2.2 2 0 0 2 2 2 2 Pex26 protein Presenilin PF01080.17 CDI84303.1 - 0.0079 15.0 19.5 0.011 14.5 19.5 1.2 1 0 0 1 1 1 1 Presenilin PIP5K PF01504.18 CDI84303.1 - 0.0085 15.3 9.3 0.02 14.2 4.1 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase SLC12 PF03522.15 CDI84303.1 - 0.02 14.0 13.0 0.027 13.5 13.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CTK3_C PF12350.8 CDI84303.1 - 0.022 14.9 0.8 0.022 14.9 0.8 2.2 2 0 0 2 2 1 0 CTD kinase subunit gamma CTK3 C-terminus DUF4770 PF15994.5 CDI84303.1 - 0.024 14.9 17.1 0.11 12.7 6.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) TERB2 PF15101.6 CDI84303.1 - 0.044 13.8 20.9 0.047 13.7 9.9 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF5523 PF17661.1 CDI84303.1 - 0.12 12.1 23.9 0.45 10.2 14.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) SRP-alpha_N PF04086.13 CDI84303.1 - 0.13 12.2 17.8 0.17 11.8 17.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal D123 PF07065.14 CDI84303.1 - 0.16 11.1 12.1 0.24 10.5 0.2 2.1 2 0 0 2 2 2 0 D123 Ureide_permease PF07168.11 CDI84303.1 - 0.28 9.9 7.3 0.1 11.3 1.9 2.0 2 0 0 2 2 2 0 Ureide permease DUF2151 PF10221.9 CDI84303.1 - 0.32 9.5 9.3 0.44 9.1 9.3 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator RR_TM4-6 PF06459.12 CDI84303.1 - 0.35 10.6 21.5 0.74 9.6 13.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5327 PF17261.2 CDI84303.1 - 0.36 11.6 28.4 2.3 9.0 16.7 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5327) DUF3408 PF11888.8 CDI84303.1 - 0.41 10.8 20.2 3.5 7.8 12.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Pinin_SDK_memA PF04696.13 CDI84303.1 - 0.41 10.7 38.3 1.9 8.5 22.1 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Folliculin PF11704.8 CDI84303.1 - 0.46 10.4 14.8 0.75 9.7 5.5 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport XRN_M PF17846.1 CDI84303.1 - 0.46 9.4 10.9 0.62 9.0 10.9 1.2 1 0 0 1 1 1 0 Xrn1 helical domain FYDLN_acid PF09538.10 CDI84303.1 - 0.5 11.1 15.7 4.1 8.1 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) ESM4 PF15952.5 CDI84303.1 - 0.51 10.8 26.8 0.097 13.1 2.9 2.4 2 0 0 2 2 2 0 Enhancer of split M4 family Peptidase_S49_N PF08496.10 CDI84303.1 - 0.51 10.4 19.7 1.9 8.5 11.4 2.4 2 1 0 2 2 2 0 Peptidase family S49 N-terminal Folate_carrier PF01770.18 CDI84303.1 - 0.56 8.9 10.3 0.97 8.1 4.1 2.1 2 0 0 2 2 2 0 Reduced folate carrier PAT1 PF09770.9 CDI84303.1 - 0.56 8.4 33.9 0.69 8.1 33.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ATAD4 PF15321.6 CDI84303.1 - 0.7 11.3 12.5 4.3 8.7 6.1 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Sin_N PF04801.13 CDI84303.1 - 0.71 9.0 32.6 0.31 10.2 4.4 2.1 2 0 0 2 2 2 0 Sin-like protein conserved region Ndc1_Nup PF09531.10 CDI84303.1 - 0.74 8.4 18.3 1 8.0 18.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNA_pol_Rpc4 PF05132.14 CDI84303.1 - 0.94 9.9 17.1 1.3 9.5 9.3 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 GREB1 PF15782.5 CDI84303.1 - 1 6.4 17.5 1.2 6.1 17.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Eapp_C PF10238.9 CDI84303.1 - 1.3 9.1 19.4 4.3 7.4 11.3 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF1764 PF08576.10 CDI84303.1 - 1.8 9.5 16.9 2.8 8.9 9.5 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) CRT10 PF08728.10 CDI84303.1 - 2.5 6.1 9.1 3 5.9 9.1 1.0 1 0 0 1 1 1 0 CRT10 eIF-3_zeta PF05091.12 CDI84303.1 - 2.6 6.9 24.6 1.9 7.4 15.4 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MPM1 PF17234.2 CDI84303.1 - 2.9 8.1 20.7 2.4 8.4 11.3 2.1 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF868 PF05910.12 CDI84303.1 - 3.1 7.4 8.3 2.9 7.5 2.5 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF868) Prothymosin PF03247.14 CDI84303.1 - 3.6 8.1 25.6 0.34 11.4 1.7 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family CSG2 PF16965.5 CDI84303.1 - 3.8 6.4 8.5 1.7 7.5 3.6 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator O-antigen_lig PF13425.6 CDI84303.1 - 4 6.1 8.1 15 4.2 0.1 2.0 2 0 0 2 2 2 0 O-antigen ligase like membrane protein CBP_BcsG PF11658.8 CDI84303.1 - 4.6 5.5 14.7 0.46 8.8 5.2 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG BBL5 PF07289.11 CDI84303.1 - 5.7 5.9 11.8 2.1 7.3 6.5 2.0 2 0 0 2 2 2 0 Bardet-Biedl syndrome 5 protein Kei1 PF08552.11 CDI84303.1 - 6.3 6.6 13.2 2.2 8.1 5.7 2.2 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Serinc PF03348.15 CDI84303.1 - 6.7 5.5 12.4 0.86 8.5 4.6 2.0 2 0 0 2 2 2 0 Serine incorporator (Serinc) Peptidase_S64 PF08192.11 CDI84303.1 - 8.3 4.8 19.2 11 4.3 19.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 RNA_pol_Rbc25 PF08292.12 CDI84306.1 - 2.5e-12 47.2 0.2 6.3e-09 36.2 0.3 2.9 2 1 0 2 2 2 2 RNA polymerase III subunit Rpc25 EIF4E-T PF10477.9 CDI84307.1 - 3e-05 23.1 0.2 3e-05 23.1 0.2 5.2 2 2 1 4 4 4 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E N6_N4_Mtase PF01555.18 CDI84307.1 - 0.0028 17.4 0.0 58 3.3 0.0 4.2 3 2 0 3 3 3 0 DNA methylase RskA PF10099.9 CDI84307.1 - 0.0033 17.8 12.8 0.0033 17.8 12.8 9.5 2 2 4 8 8 8 4 Anti-sigma-K factor rskA Connexin PF00029.19 CDI84307.1 - 0.089 12.5 0.1 0.089 12.5 0.1 7.3 5 2 0 5 5 5 0 Connexin GTP_EFTU PF00009.27 CDI84308.1 - 2.4e-44 151.2 0.0 6.9e-36 123.6 0.0 2.9 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDI84308.1 - 5e-09 36.1 0.0 0.0004 20.4 0.0 2.6 1 1 1 2 2 2 2 Elongation factor G C-terminus EFG_II PF14492.6 CDI84308.1 - 8.8e-06 25.7 0.0 1.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CDI84308.1 - 0.0089 16.1 0.0 0.03 14.4 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CDI84308.1 - 0.57 9.5 0.0 0.57 9.5 0.0 3.3 6 0 0 6 6 6 0 AIG1 family DUF2722 PF10846.8 CDI84308.1 - 7.2 5.4 20.6 0.28 10.1 8.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Peptidase_S28 PF05577.12 CDI84309.1 - 2.1e-31 109.2 7.7 9.2e-24 84.0 0.0 3.2 1 1 2 3 3 3 3 Serine carboxypeptidase S28 DUF3446 PF11928.8 CDI84309.1 - 0.0055 17.0 6.7 0.017 15.4 6.7 1.8 1 0 0 1 1 1 1 Early growth response N-terminal domain Myc_N PF01056.18 CDI84309.1 - 0.012 15.5 3.1 0.017 15.1 3.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region SUIM_assoc PF16619.5 CDI84309.1 - 0.014 15.4 11.7 0.014 15.4 11.7 2.3 2 0 0 2 2 1 0 Unstructured region C-term to UIM in Ataxin3 3HBOH PF10605.9 CDI84309.1 - 0.021 13.1 0.3 0.029 12.6 0.3 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) Hydrolase_4 PF12146.8 CDI84309.1 - 0.022 14.0 0.1 0.072 12.3 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 TCP PF03634.13 CDI84309.1 - 0.23 12.0 7.2 0.12 13.0 3.7 2.1 2 0 0 2 2 2 0 TCP family transcription factor IMUP PF15761.5 CDI84309.1 - 0.48 11.1 11.1 1.3 9.8 9.6 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein PRP38_assoc PF12871.7 CDI84309.1 - 0.53 10.9 17.4 1.3 9.7 17.4 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Apis_Csd PF11671.8 CDI84309.1 - 1.2 9.1 4.8 3.2 7.8 4.8 1.7 1 0 0 1 1 1 0 Complementary sex determiner protein SR-25 PF10500.9 CDI84309.1 - 1.3 8.5 17.8 2.1 7.9 17.1 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 CDI84310.1 - 0.00021 21.4 24.3 0.00034 20.7 24.3 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF755 PF05501.11 CDI84310.1 - 0.0014 18.9 5.7 0.0014 18.9 5.7 2.9 2 1 1 3 3 2 1 Domain of unknown function (DUF755) Suf PF05843.14 CDI84310.1 - 0.0058 16.6 3.1 0.0058 16.6 3.1 2.1 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 CDI84310.1 - 0.024 14.7 6.9 0.038 14.1 6.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BAF1_ABF1 PF04684.13 CDI84310.1 - 0.031 13.4 9.2 0.041 13.0 9.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FUSC PF04632.12 CDI84310.1 - 0.052 12.1 13.2 0.069 11.7 13.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Menin PF05053.13 CDI84310.1 - 0.064 11.6 13.9 0.091 11.1 13.9 1.2 1 0 0 1 1 1 0 Menin FAM76 PF16046.5 CDI84310.1 - 0.63 9.3 13.1 2.1 7.6 2.7 2.1 2 0 0 2 2 2 0 FAM76 protein DUF743 PF05332.11 CDI84310.1 - 0.83 9.7 8.6 1.7 8.7 8.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF743) GREB1 PF15782.5 CDI84310.1 - 1 6.4 12.2 1.4 5.9 12.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apc15p PF05841.11 CDI84310.1 - 2 9.2 20.6 3.7 8.4 6.0 2.3 2 0 0 2 2 2 0 Apc15p protein DUF572 PF04502.13 CDI84310.1 - 3.7 7.1 19.6 5.8 6.4 19.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SARAF PF06682.12 CDI84310.1 - 4.7 6.8 13.7 0.68 9.5 0.8 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Hid1 PF12722.7 CDI84310.1 - 6.9 4.7 11.7 9.4 4.2 11.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein OATP PF03137.20 CDI84310.1 - 7.7 4.7 6.8 1.7 6.8 0.3 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2052 PF09747.9 CDI84310.1 - 8.3 6.5 16.4 14 5.8 16.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 CDI84311.1 - 0.0028 16.5 0.7 1.1 8.0 0.0 2.1 2 0 0 2 2 2 2 Presenilin DUF4228 PF14009.6 CDI84311.1 - 0.11 12.9 8.6 2.3 8.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) DDHD PF02862.17 CDI84311.1 - 0.23 11.6 7.4 2.6 8.1 0.2 2.2 2 0 0 2 2 2 0 DDHD domain Glyco_hydro_1 PF00232.18 CDI84311.1 - 1.6 7.1 3.5 4.5 5.6 0.1 2.0 2 0 0 2 2 2 0 Glycosyl hydrolase family 1 RAP1 PF07218.11 CDI84311.1 - 2.4 6.3 15.4 3.2 5.9 15.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Tmemb_cc2 PF10267.9 CDI84311.1 - 3.3 6.7 15.5 0.2 10.8 5.4 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Neur_chan_memb PF02932.16 CDI84311.1 - 4.2 7.4 7.0 2.8 7.9 0.1 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Apt1 PF10351.9 CDI84311.1 - 5 5.9 17.3 3.5 6.4 12.0 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain SPX PF03105.19 CDI84311.1 - 7.8 6.3 17.3 3.4 7.5 10.5 2.1 2 0 0 2 2 2 0 SPX domain EPL1 PF10513.9 CDI84311.1 - 8.4 6.8 12.1 2 8.8 1.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like Band_7_C PF16200.5 CDI84314.1 - 3.9e-20 71.7 0.0 9.9e-20 70.4 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7 PF01145.25 CDI84314.1 - 2.4e-09 37.5 0.0 2.4e-09 37.5 0.0 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CDI84314.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family RMI1_N PF08585.12 CDI84314.1 - 0.13 12.0 0.1 0.15 11.8 0.1 1.1 1 0 0 1 1 1 0 RecQ mediated genome instability protein Arf PF00025.21 CDI84315.1 - 7.5e-30 103.7 0.0 9.9e-30 103.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CDI84315.1 - 0.00027 20.6 0.0 0.00035 20.2 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDI84315.1 - 0.0013 18.2 0.0 0.015 14.7 0.0 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDI84315.1 - 0.045 14.0 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Capsid-VNN PF11729.8 CDI84316.1 - 0.066 12.2 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 nodavirus capsid protein Sec16 PF12932.7 CDI84317.1 - 0.11 13.1 0.4 0.26 11.9 0.1 1.6 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region zf-C2H2_8 PF15909.5 CDI84317.1 - 0.14 12.4 2.4 1.2 9.5 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc ribbon 2OG-FeII_Oxy_3 PF13640.6 CDI84318.1 - 1.3e-07 32.4 0.0 2.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Spt20 PF12090.8 CDI84319.1 - 0.013 15.2 5.7 0.019 14.5 5.7 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CDI84319.1 - 4.2 7.3 11.3 8.9 6.2 11.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cytochrom_B561 PF03188.16 CDI84320.1 - 0.0037 17.4 2.9 0.28 11.3 0.2 2.6 2 1 1 3 3 3 2 Eukaryotic cytochrome b561 PP2C PF00481.21 CDI84321.1 - 2.9e-38 132.0 0.8 1.2e-26 93.9 0.0 4.1 4 1 0 4 4 4 3 Protein phosphatase 2C zf-RanBP PF00641.18 CDI84323.1 - 3e-15 55.2 20.0 1.4e-09 37.1 4.8 2.2 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-P11 PF03854.14 CDI84323.1 - 0.01 15.5 4.0 0.53 10.0 0.2 2.2 2 0 0 2 2 2 0 P-11 zinc finger Spt20 PF12090.8 CDI84323.1 - 0.013 15.2 8.5 0.017 14.7 8.5 1.1 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 CDI84323.1 - 0.44 9.2 3.4 0.55 8.9 3.4 1.1 1 0 0 1 1 1 0 Presenilin RecR PF02132.15 CDI84323.1 - 0.94 9.1 6.5 0.36 10.4 0.9 2.3 2 0 0 2 2 2 0 RecR protein Protamine_P2 PF00841.19 CDI84323.1 - 1.5 9.3 9.4 3.9 8.0 9.4 1.7 1 0 0 1 1 1 0 Sperm histone P2 zf-ribbon_3 PF13248.6 CDI84323.1 - 2.3 7.7 14.0 3.2 7.3 0.5 3.4 3 0 0 3 3 3 0 zinc-ribbon domain PTPRCAP PF15713.5 CDI84323.1 - 5.4 7.3 10.3 2.8 8.2 8.3 1.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF4834 PF16118.5 CDI84323.1 - 6.3 7.8 6.4 11 7.0 6.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TF_Zn_Ribbon PF08271.12 CDI84324.1 - 0.039 13.5 0.5 0.073 12.6 0.5 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding AP2 PF00847.20 CDI84326.1 - 8.9e-09 35.5 7.9 8.9e-09 35.5 7.9 4.9 4 1 0 4 4 4 2 AP2 domain ACDC PF14733.6 CDI84326.1 - 0.036 14.4 0.0 0.036 14.4 0.0 2.6 2 0 0 2 2 2 0 AP2-coincident C-terminal 14-3-3 PF00244.20 CDI84329.1 - 3.9e-08 33.1 0.2 2e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 14-3-3 protein Spt20 PF12090.8 CDI84329.1 - 0.2 11.2 2.7 0.46 10.1 2.5 1.6 2 0 0 2 2 2 0 Spt20 family PALP PF00291.25 CDI84330.1 - 2.2e-45 155.3 3.6 2.2e-45 155.3 3.6 2.6 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme mRNA_cap_enzyme PF01331.19 CDI84333.1 - 3.6e-24 85.7 1.2 6.2e-14 52.3 0.1 3.6 2 1 1 3 3 3 2 mRNA capping enzyme, catalytic domain TFIIA PF03153.13 CDI84333.1 - 0.0015 18.6 0.2 0.0019 18.3 0.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 CDI84333.1 - 0.0098 15.9 7.6 0.017 15.2 7.6 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 CDI84333.1 - 0.016 14.2 0.2 0.02 13.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DNA_ligase_A_M PF01068.21 CDI84333.1 - 0.19 11.3 2.3 10 5.7 2.4 2.3 1 1 0 1 1 1 0 ATP dependent DNA ligase domain MscS_TM PF12794.7 CDI84333.1 - 0.46 9.3 1.7 0.68 8.7 1.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Spt20 PF12090.8 CDI84333.1 - 3.7 7.1 11.3 5.5 6.5 11.3 1.2 1 0 0 1 1 1 0 Spt20 family Halogen_Hydrol PF10112.9 CDI84334.1 - 0.00051 20.1 0.1 0.00051 20.1 0.1 2.2 2 0 0 2 2 2 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein Regnase_1_C PF18561.1 CDI84334.1 - 0.0094 15.7 0.1 0.023 14.4 0.1 1.6 1 0 0 1 1 1 1 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain OAD_gamma PF04277.13 CDI84334.1 - 1.7 9.3 0.0 1.7 9.3 0.0 3.8 3 1 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain MAT1 PF06391.13 CDI84334.1 - 2.5 7.9 18.4 3.1 7.6 11.4 2.5 2 1 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Hydin_ADK PF17213.3 CDI84334.1 - 6.9 6.9 10.7 1.5 9.0 7.4 1.6 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain IMUP PF15761.5 CDI84335.1 - 6e-05 23.7 18.1 6e-05 23.7 18.1 4.4 3 1 1 4 4 4 2 Immortalisation up-regulated protein SR-25 PF10500.9 CDI84335.1 - 1.1 8.9 88.7 0.04 13.5 32.2 4.1 2 2 1 3 3 3 0 Nuclear RNA-splicing-associated protein DUF4692 PF15763.5 CDI84335.1 - 1.6 9.2 41.0 0.26 11.7 10.6 4.0 3 2 1 4 4 4 0 Regulator of human erythroid cell expansion (RHEX) WD40 PF00400.32 CDI84336.1 - 6.1e-22 77.5 2.0 3.9e-08 33.8 0.0 4.0 3 0 0 3 3 3 3 WD domain, G-beta repeat LisH_TPL PF17814.1 CDI84336.1 - 6e-12 45.0 0.0 1.2e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 CDI84336.1 - 2.8e-07 29.8 0.4 0.0068 15.4 0.0 3.1 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 CDI84336.1 - 5.5e-07 29.8 0.0 0.99 9.8 0.0 3.5 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDI84336.1 - 0.00032 20.6 0.0 9 6.1 0.0 3.4 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CDI84336.1 - 0.018 13.7 0.0 0.73 8.4 0.0 2.3 2 0 0 2 2 2 0 Nucleoporin Nup120/160 BURP PF03181.15 CDI84336.1 - 0.019 14.6 0.1 3.2 7.3 0.1 2.4 2 0 0 2 2 2 0 BURP domain XPC-binding PF09280.11 CDI84336.1 - 0.026 14.3 0.6 1 9.1 0.1 2.5 2 0 0 2 2 2 0 XPC-binding domain PD40 PF07676.12 CDI84336.1 - 0.047 13.7 0.0 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat LisH PF08513.11 CDI84336.1 - 0.076 13.0 0.0 0.39 10.7 0.0 2.1 2 0 0 2 2 2 0 LisH FACT-Spt16_Nlob PF14826.6 CDI84337.1 - 1.5e-16 60.6 0.1 2.1e-16 60.1 0.1 1.3 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain TFIIA PF03153.13 CDI84337.1 - 0.00031 20.9 23.5 0.00031 20.9 23.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Tim29 PF10171.9 CDI84337.1 - 0.048 13.2 0.8 0.098 12.1 0.8 1.5 1 0 0 1 1 1 0 Translocase of the Inner Mitochondrial membrane 29 DUF5320 PF17253.2 CDI84337.1 - 3.1 8.9 4.7 8.6 7.5 4.7 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5320) ATP-synt_ab_N PF02874.23 CDI84339.1 - 2e-17 63.5 0.6 3.8e-17 62.6 0.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 CDI84339.1 - 8.4e-05 22.7 0.1 0.00012 22.2 0.1 1.2 1 0 0 1 1 1 1 HAS barrel domain QueH PF02677.14 CDI84339.1 - 0.00032 20.8 0.4 0.00042 20.4 0.4 1.1 1 0 0 1 1 1 1 Epoxyqueuosine reductase QueH PTS_EIIC_2 PF13303.6 CDI84339.1 - 0.03 13.4 6.7 0.048 12.7 6.7 1.3 1 0 0 1 1 1 0 Phosphotransferase system, EIIC DUF3138 PF11336.8 CDI84339.1 - 1.6 7.3 8.1 2 7.0 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Spt20 PF12090.8 CDI84347.1 - 0.0022 17.6 7.1 0.0022 17.6 7.1 2.2 2 0 0 2 2 2 1 Spt20 family Suf PF05843.14 CDI84347.1 - 0.011 15.8 7.3 0.1 12.6 1.7 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) TCP PF03634.13 CDI84347.1 - 0.035 14.7 1.6 0.035 14.7 1.6 2.2 2 0 0 2 2 2 0 TCP family transcription factor Meth_synt_1 PF08267.12 CDI84347.1 - 0.037 13.5 0.0 0.048 13.2 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain Tim54 PF11711.8 CDI84347.1 - 0.11 11.2 5.0 0.61 8.8 0.2 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 CDI84347.1 - 0.14 10.9 12.3 0.37 9.5 1.9 2.2 2 0 0 2 2 2 0 Presenilin MID_MedPIWI PF18296.1 CDI84347.1 - 0.53 10.0 19.5 0.45 10.3 2.3 2.2 2 0 0 2 2 2 0 MID domain of medPIWI Neur_chan_memb PF02932.16 CDI84347.1 - 0.63 10.0 6.0 3.7 7.5 0.2 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PGA2 PF07543.12 CDI84347.1 - 0.65 10.0 5.7 1.6 8.7 0.1 2.4 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF572 PF04502.13 CDI84347.1 - 0.74 9.4 9.7 1.7 8.2 0.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Rxt3 PF08642.10 CDI84347.1 - 1.2 9.9 6.4 11 6.8 1.6 2.6 2 1 0 2 2 2 0 Histone deacetylation protein Rxt3 Orf78 PF06024.12 CDI84347.1 - 1.5 9.1 7.2 0.92 9.8 0.5 2.5 2 0 0 2 2 2 0 Orf78 (ac78) EOS1 PF12326.8 CDI84347.1 - 3.9 7.4 6.9 9.1 6.2 0.4 2.2 2 0 0 2 2 2 0 N-glycosylation protein rRNA_processing PF08524.11 CDI84347.1 - 4.2 7.4 14.5 1.6 8.7 2.7 2.2 2 0 0 2 2 2 0 rRNA processing Rsc14 PF08586.10 CDI84347.1 - 8.5 7.3 9.7 0.14 13.0 1.2 2.2 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Pkinase PF00069.25 CDI84348.1 - 7.2e-68 228.8 0.0 7.2e-68 228.8 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84348.1 - 2.1e-28 99.3 0.0 2.1e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDI84348.1 - 0.00014 20.8 0.6 0.00014 20.8 0.6 3.6 4 1 0 4 4 4 1 Fungal protein kinase Thioredoxin_8 PF13905.6 CDI84349.1 - 2.5e-48 162.4 0.0 7.3e-29 100.0 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 CDI84349.1 - 2.3e-10 40.9 0.0 9.2e-07 29.3 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin-like domain SCO1-SenC PF02630.14 CDI84349.1 - 3e-08 33.7 0.0 3.9e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 SCO1/SenC Redoxin PF08534.10 CDI84349.1 - 3.9e-08 33.1 0.0 1.6e-06 27.9 0.0 2.4 2 0 0 2 2 2 1 Redoxin AhpC-TSA PF00578.21 CDI84349.1 - 1.6e-07 31.3 0.0 3.4e-06 27.0 0.0 2.6 2 1 0 3 3 3 1 AhpC/TSA family Thioredoxin PF00085.20 CDI84349.1 - 2.7e-07 30.5 0.0 5.6e-05 23.1 0.1 3.5 3 1 1 4 4 4 1 Thioredoxin Glutaredoxin PF00462.24 CDI84349.1 - 0.00092 19.4 0.3 0.74 10.1 0.2 3.8 3 1 0 3 3 2 1 Glutaredoxin Thioredoxin_6 PF13848.6 CDI84349.1 - 0.0014 18.5 1.3 15 5.5 0.0 3.9 4 0 0 4 4 4 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDI84349.1 - 0.015 15.1 0.0 0.054 13.3 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin Response_reg PF00072.24 CDI84349.1 - 0.097 12.8 0.0 8.5 6.6 0.0 2.9 2 0 0 2 2 2 0 Response regulator receiver domain DUF3970 PF13113.6 CDI84349.1 - 0.22 11.8 0.6 0.56 10.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) XRN_N PF03159.18 CDI84350.1 - 8.5e-26 90.9 7.7 5.7e-19 68.5 0.0 3.5 3 1 0 3 3 3 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDI84350.1 - 0.00013 21.1 16.2 0.013 14.5 0.0 3.6 3 0 0 3 3 3 2 Xrn1 helical domain Dicty_REP PF05086.12 CDI84350.1 - 0.79 7.6 6.3 1.8 6.4 6.3 1.5 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AAA_6 PF12774.7 CDI84351.1 - 3.5e-131 437.0 0.0 4.3e-130 433.5 0.0 2.9 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDI84351.1 - 2.3e-113 379.3 6.6 2.3e-113 379.3 6.6 3.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 CDI84351.1 - 1.7e-111 373.7 4.1 1.7e-111 373.7 4.1 4.8 4 1 1 5 5 5 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 CDI84351.1 - 4.1e-68 228.8 0.1 4.1e-68 228.8 0.1 3.7 4 0 0 4 4 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 CDI84351.1 - 1.1e-58 198.6 0.0 1.5e-57 194.9 0.0 3.0 3 0 0 3 3 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 CDI84351.1 - 6.1e-42 143.9 0.5 1.1e-40 139.8 0.4 2.7 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 CDI84351.1 - 1.4e-35 122.4 0.0 2.4e-29 102.1 0.0 4.4 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 CDI84351.1 - 1.1e-32 113.1 0.0 2.5e-32 112.0 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDI84351.1 - 8.1e-31 106.6 0.7 7.9e-30 103.4 0.0 3.3 2 0 0 2 2 1 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 CDI84351.1 - 3.7e-29 101.5 0.0 4.5e-11 42.9 0.0 6.2 4 2 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDI84351.1 - 1.3e-20 73.8 0.0 4.9e-20 71.9 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 CDI84351.1 - 1.9e-20 73.2 16.1 5.8e-15 55.2 1.0 2.4 1 1 1 2 2 2 2 Microtubule-binding stalk of dynein motor AAA PF00004.29 CDI84351.1 - 1.3e-14 54.7 0.5 0.0062 17.0 0.0 6.1 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDI84351.1 - 1e-11 45.2 2.7 0.00073 19.8 0.0 7.2 5 1 0 6 6 6 1 AAA domain AAA_16 PF13191.6 CDI84351.1 - 1.5e-07 31.9 3.5 5.7 7.3 0.0 7.4 6 0 0 6 6 5 0 AAA ATPase domain AAA_18 PF13238.6 CDI84351.1 - 1.7e-06 28.6 0.0 8 7.0 0.0 5.4 4 0 0 4 4 4 0 AAA domain T2SSE PF00437.20 CDI84351.1 - 7.1e-06 25.3 0.0 0.1 11.7 0.0 3.4 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_30 PF13604.6 CDI84351.1 - 9.9e-05 22.1 0.9 5.7 6.6 0.0 4.9 4 0 0 4 4 4 0 AAA domain AAA_25 PF13481.6 CDI84351.1 - 0.00013 21.6 0.9 0.012 15.1 0.0 3.7 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.17 CDI84351.1 - 0.00025 20.8 0.1 0.23 11.2 0.0 4.8 4 0 0 4 4 4 1 IstB-like ATP binding protein TelA PF05816.11 CDI84351.1 - 0.00043 19.4 4.8 0.00043 19.4 4.8 3.3 2 0 0 2 2 1 1 Toxic anion resistance protein (TelA) AAA_19 PF13245.6 CDI84351.1 - 0.0039 17.5 2.4 0.23 11.8 0.0 4.7 5 0 0 5 5 4 1 AAA domain Mg_chelatase PF01078.21 CDI84351.1 - 0.0069 15.8 3.9 6.7 6.0 0.0 4.5 3 1 1 4 4 4 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CDI84351.1 - 0.0095 15.9 0.4 23 5.0 0.0 4.2 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CDI84351.1 - 0.011 15.9 9.7 0.75 10.0 0.0 5.1 6 0 0 6 6 4 0 AAA domain Rad17 PF03215.15 CDI84351.1 - 0.017 15.0 1.7 19 5.1 0.0 4.5 6 0 0 6 6 3 0 Rad17 P-loop domain Sigma54_activat PF00158.26 CDI84351.1 - 0.021 14.5 0.0 53 3.5 0.0 3.8 3 0 0 3 3 3 0 Sigma-54 interaction domain cobW PF02492.19 CDI84351.1 - 0.025 14.2 0.2 0.22 11.1 0.0 2.6 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Asn_synthase PF00733.21 CDI84351.1 - 0.026 14.2 0.2 0.069 12.8 0.2 1.7 1 0 0 1 1 1 0 Asparagine synthase RuvB_N PF05496.12 CDI84351.1 - 0.04 13.7 0.1 3.9 7.2 0.0 3.2 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_1 PF17857.1 CDI84351.1 - 0.041 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA+ lid domain RNA_helicase PF00910.22 CDI84351.1 - 0.069 13.5 0.1 1.2e+02 3.1 0.0 4.6 4 0 0 4 4 4 0 RNA helicase ResIII PF04851.15 CDI84351.1 - 0.1 12.6 0.4 7.6 6.5 0.0 3.8 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit MPS2 PF17060.5 CDI84351.1 - 0.17 11.1 13.0 0.38 10.0 3.4 2.7 2 0 0 2 2 2 0 Monopolar spindle protein 2 AAA_24 PF13479.6 CDI84351.1 - 0.42 10.3 4.1 20 4.9 0.0 3.9 4 0 0 4 4 3 0 AAA domain NBD94 PF16830.5 CDI84351.1 - 0.81 10.1 7.1 0.36 11.2 2.7 2.7 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH ATG16 PF08614.11 CDI84351.1 - 1 9.6 25.9 5.1 7.3 9.9 3.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4615 PF15393.6 CDI84351.1 - 1.8 9.1 7.0 1.7 9.2 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) PTPA PF03095.15 CDI84351.1 - 2.8 7.3 5.4 0.73 9.2 0.3 2.7 2 0 0 2 2 1 0 Phosphotyrosyl phosphate activator (PTPA) protein ABC_tran PF00005.27 CDI84351.1 - 3.9 8.0 10.9 18 5.9 0.0 5.2 6 0 0 6 6 3 0 ABC transporter Ribosomal_L29 PF00831.23 CDI84352.1 - 5.4e-18 64.7 2.4 5.4e-18 64.7 2.4 2.1 2 1 0 2 2 2 1 Ribosomal L29 protein Nup54_57_C PF18570.1 CDI84352.1 - 0.13 11.9 0.6 0.13 11.9 0.6 1.9 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain TLD PF07534.16 CDI84353.1 - 2e-08 34.6 0.4 4.2e-05 23.8 0.1 2.9 2 1 1 3 3 3 2 TLD Glyco_trans_4_4 PF13579.6 CDI84353.1 - 0.025 15.0 0.7 0.025 15.0 0.7 1.8 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain SUI1 PF01253.22 CDI84354.1 - 1.7e-15 57.3 0.1 3.4e-15 56.3 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 MecA PF05389.12 CDI84358.1 - 0.0085 15.8 0.9 0.01 15.5 0.9 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) CPSF100_C PF13299.6 CDI84358.1 - 0.027 14.7 5.5 0.053 13.7 5.5 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spt20 PF12090.8 CDI84358.1 - 0.029 14.0 31.2 0.048 13.3 31.2 1.3 1 0 0 1 1 1 0 Spt20 family SpoIIP PF07454.11 CDI84358.1 - 0.03 13.8 5.4 0.037 13.5 5.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Roughex PF06020.11 CDI84358.1 - 0.03 13.4 8.6 0.051 12.7 8.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein MMR1 PF08505.10 CDI84358.1 - 0.048 14.0 15.2 0.068 13.5 15.2 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.9 CDI84358.1 - 0.059 11.7 15.5 0.064 11.5 15.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EPL1 PF10513.9 CDI84358.1 - 0.065 13.6 5.7 0.089 13.2 5.7 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF2126 PF09899.9 CDI84358.1 - 0.075 11.1 6.7 0.097 10.7 6.7 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) eIF-3_zeta PF05091.12 CDI84358.1 - 0.084 11.8 9.6 0.11 11.5 9.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3721 PF12518.8 CDI84358.1 - 0.12 12.2 1.5 15 5.5 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function Presenilin PF01080.17 CDI84358.1 - 0.13 11.0 10.1 0.16 10.7 10.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 CDI84358.1 - 0.15 11.4 8.6 0.27 10.6 8.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) V_ATPase_I PF01496.19 CDI84358.1 - 0.19 9.6 4.0 0.22 9.4 4.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Suf PF05843.14 CDI84358.1 - 0.25 11.3 15.2 0.43 10.5 15.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 CDI84358.1 - 0.25 11.3 36.8 0.34 10.8 36.2 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Connexin PF00029.19 CDI84358.1 - 0.25 11.1 2.7 0.35 10.6 2.7 1.3 1 0 0 1 1 1 0 Connexin DUF3408 PF11888.8 CDI84358.1 - 0.54 10.4 9.2 0.91 9.7 9.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) MAM1 PF10434.9 CDI84358.1 - 0.57 9.7 11.3 0.82 9.2 11.3 1.2 1 0 0 1 1 1 0 Monopolin complex protein MAM1 Lin-8 PF03353.15 CDI84358.1 - 0.78 9.2 12.7 1.2 8.7 12.7 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ndc1_Nup PF09531.10 CDI84358.1 - 1 8.0 10.8 1.2 7.8 10.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.12 CDI84358.1 - 1.2 8.9 8.5 1.7 8.4 8.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 CDI84358.1 - 1.3 9.0 6.6 2.3 8.2 6.6 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Plasmodium_Vir PF05795.11 CDI84358.1 - 1.7 8.0 4.5 1.9 7.8 4.5 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ALMT PF11744.8 CDI84358.1 - 1.7 7.4 5.1 1.9 7.2 5.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 CDI84358.1 - 1.8 7.5 4.2 2.6 7.0 4.2 1.2 1 0 0 1 1 1 0 CLN3 protein Hid1 PF12722.7 CDI84358.1 - 2.5 6.1 10.2 2.7 6.0 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein EIIBC-GUT_N PF03612.14 CDI84358.1 - 2.9 7.6 9.1 4.8 6.9 9.1 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Baculo_PP31 PF05311.11 CDI84358.1 - 3.2 7.2 8.6 4.7 6.6 8.6 1.3 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2464 PF10240.9 CDI84358.1 - 4.1 6.9 8.9 8.1 5.9 8.9 1.5 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF1980 PF09323.10 CDI84358.1 - 5.4 6.9 7.9 2.6 7.9 3.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) SRP-alpha_N PF04086.13 CDI84358.1 - 5.6 6.8 14.2 9.7 6.0 14.2 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal GREB1 PF15782.5 CDI84358.1 - 7.7 3.5 13.3 8.5 3.3 13.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer tRNA-synt_1 PF00133.22 CDI84359.1 - 4.6e-68 229.9 0.2 5.7e-68 229.6 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDI84359.1 - 1.9e-33 115.6 0.1 5.2e-32 110.9 0.1 2.6 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA Val_tRNA-synt_C PF10458.9 CDI84359.1 - 3.2e-06 27.3 5.2 7e-06 26.2 5.2 1.6 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1g PF09334.11 CDI84359.1 - 5.6e-06 25.3 0.6 0.074 11.8 0.2 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1b PF00579.25 CDI84359.1 - 0.0041 16.5 0.1 0.008 15.5 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.18 CDI84359.1 - 0.052 12.5 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Enkurin PF13864.6 CDI84359.1 - 0.26 11.8 4.2 2.9 8.4 4.2 2.6 1 1 0 1 1 1 0 Calmodulin-binding RskA PF10099.9 CDI84361.1 - 1.4e-06 28.7 0.1 1.4e-06 28.7 0.1 9.5 6 3 2 8 8 8 3 Anti-sigma-K factor rskA SpoIIE PF07228.12 CDI84361.1 - 0.011 15.7 0.0 0.011 15.7 0.0 3.3 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) DUF2722 PF10846.8 CDI84362.1 - 0.0037 16.3 8.0 0.0037 16.3 8.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 CDI84362.1 - 0.083 13.6 11.2 0.09 13.4 11.2 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CMV_US PF08001.11 CDI84362.1 - 0.16 11.2 1.8 0.19 11.0 1.8 1.2 1 0 0 1 1 1 0 CMV US Spt20 PF12090.8 CDI84362.1 - 0.16 11.5 16.6 0.21 11.2 16.6 1.2 1 0 0 1 1 1 0 Spt20 family DUF3402 PF11882.8 CDI84362.1 - 0.37 9.8 6.1 0.4 9.7 6.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DUF3446 PF11928.8 CDI84362.1 - 0.77 10.1 8.6 1.2 9.5 8.6 1.3 1 0 0 1 1 1 0 Early growth response N-terminal domain LCIB_C_CA PF18599.1 CDI84362.1 - 1.8 7.8 4.3 2 7.7 4.3 1.1 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Presenilin PF01080.17 CDI84362.1 - 5.6 5.6 8.9 5.7 5.6 8.9 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 CDI84362.1 - 6.6 6.6 18.5 6.8 6.6 18.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI84362.1 - 7.6 6.4 10.1 8.2 6.3 10.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Androgen_recep PF02166.16 CDI84362.1 - 9.1 5.0 16.3 11 4.7 16.3 1.3 1 0 0 1 1 1 0 Androgen receptor TFIIA PF03153.13 CDI84365.1 - 4.5e-05 23.6 21.0 5.5e-05 23.3 21.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit AAA_17 PF13207.6 CDI84365.1 - 0.007 16.8 0.3 0.007 16.8 0.3 1.9 2 0 0 2 2 2 1 AAA domain LEAP-2 PF07359.11 CDI84365.1 - 0.013 15.3 0.6 0.013 15.3 0.6 2.8 2 1 1 3 3 3 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) LETM1 PF07766.13 CDI84365.1 - 0.017 14.5 7.5 0.017 14.5 7.5 2.0 2 0 0 2 2 2 0 LETM1-like protein DUF4175 PF13779.6 CDI84365.1 - 0.11 10.4 28.3 0.13 10.1 28.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAT1 PF09770.9 CDI84365.1 - 0.14 10.4 21.2 0.19 10.0 21.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 CDI84365.1 - 0.19 10.4 9.3 0.24 10.1 9.3 1.2 1 0 0 1 1 1 0 Presenilin PIG-S PF10510.9 CDI84365.1 - 0.33 9.7 8.8 0.4 9.5 8.8 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein MDM10 PF12519.8 CDI84365.1 - 0.91 8.3 6.7 1.2 7.9 6.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Jnk-SapK_ap_N PF09744.9 CDI84365.1 - 1.1 9.5 21.8 2.3 8.4 3.7 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF1764 PF08576.10 CDI84365.1 - 1.1 10.2 8.9 3.6 8.6 3.2 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Connexin PF00029.19 CDI84365.1 - 1.1 8.9 7.6 0.4 10.4 3.4 1.9 2 0 0 2 2 2 0 Connexin DUF3292 PF11696.8 CDI84365.1 - 8.6 4.6 9.3 6.3 5.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) Nrap_D6 PF17407.2 CDI84366.1 - 0.085 13.1 0.1 0.39 10.9 0.1 2.2 1 0 0 1 1 1 0 Nrap protein domain 6 DUF2722 PF10846.8 CDI84367.1 - 5.7e-05 22.3 2.4 5.7e-05 22.3 2.4 5.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2722) DUF3464 PF11947.8 CDI84367.1 - 0.21 11.4 0.1 0.21 11.4 0.1 4.6 2 1 1 3 3 3 0 Photosynthesis affected mutant 68 Gti1_Pac2 PF09729.9 CDI84367.1 - 0.22 11.6 0.0 0.22 11.6 0.0 3.4 2 2 1 3 3 3 0 Gti1/Pac2 family Apt1 PF10351.9 CDI84367.1 - 4.5 6.0 0.0 4.5 6.0 0.0 3.1 2 2 0 2 2 2 0 Golgi-body localisation protein domain IF-2B PF01008.17 CDI84368.1 - 0.021 14.0 0.2 0.057 12.6 0.3 1.6 2 0 0 2 2 2 0 Initiation factor 2 subunit family KH_1 PF00013.29 CDI84368.1 - 0.11 12.3 0.0 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 KH domain Mito_carr PF00153.27 CDI84369.1 - 1.5e-37 127.4 2.2 1.6e-16 59.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Glycos_transf_1 PF00534.20 CDI84371.1 - 5e-33 114.1 0.0 9.9e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDI84371.1 - 3.3e-28 98.8 0.1 1.9e-27 96.3 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CDI84371.1 - 8.7e-25 87.7 0.0 2.4e-24 86.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDI84371.1 - 4.1e-21 76.1 0.1 7.3e-20 72.0 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Alpha-amylase_C PF02806.18 CDI84371.1 - 1e-14 54.7 0.0 2.2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Glyco_transf_5 PF08323.11 CDI84371.1 - 3.5e-13 49.8 1.3 6.5e-11 42.4 0.3 2.8 2 1 0 2 2 2 1 Starch synthase catalytic domain Alpha-amylase PF00128.24 CDI84371.1 - 1.1e-08 35.0 0.0 2.4e-06 27.3 0.0 2.2 1 1 0 2 2 2 2 Alpha amylase, catalytic domain Glyco_trans_1_2 PF13524.6 CDI84371.1 - 0.0035 17.7 0.0 0.0078 16.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.13 CDI84371.1 - 0.013 14.1 0.8 0.096 11.2 0.3 2.5 2 1 0 2 2 2 0 Glycogen synthase Glyco_trans_4_2 PF13477.6 CDI84371.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase 4-like ATG101 PF07855.12 CDI84372.1 - 1.3e-05 25.3 0.0 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 2 Autophagy-related protein 101 TTL PF03133.15 CDI84372.1 - 0.022 13.9 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin-tyrosine ligase family DUF295 PF03478.18 CDI84372.1 - 0.72 9.5 6.1 0.23 11.0 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF295) zf-CCCH_2 PF14608.6 CDI84373.1 - 2.3e-09 37.4 32.1 0.00016 22.0 5.1 3.3 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDI84373.1 - 6.1e-06 25.9 17.7 0.071 12.9 2.8 4.2 4 0 0 4 4 4 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CDI84373.1 - 0.0033 17.4 21.4 0.14 12.3 0.7 4.2 3 1 1 4 4 4 3 Zinc finger domain Nab2p_Zf1 PF18260.1 CDI84373.1 - 0.0035 17.2 12.0 0.027 14.4 3.0 2.6 2 0 0 2 2 2 2 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 PWI PF01480.17 CDI84373.1 - 0.011 16.1 0.1 0.022 15.1 0.1 1.5 1 0 0 1 1 1 0 PWI domain zf-CCCH PF00642.24 CDI84373.1 - 0.012 15.5 21.7 0.039 13.9 0.4 4.0 3 1 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DEDD_Tnp_IS110 PF01548.17 CDI84373.1 - 0.13 12.1 0.1 0.13 12.1 0.1 1.6 2 0 0 2 2 2 0 Transposase zf-CCHH PF10283.9 CDI84373.1 - 0.65 10.0 13.6 8.1 6.5 0.5 3.7 3 0 0 3 3 3 0 PBZ domain Gpi1 PF05024.15 CDI84374.1 - 7.2e-36 124.0 15.5 3.7e-26 92.4 5.4 2.9 3 0 0 3 3 3 2 N-acetylglucosaminyl transferase component (Gpi1) DRY_EERY PF09750.9 CDI84374.1 - 8.5 6.7 7.2 3.5 7.9 0.1 2.8 2 0 0 2 2 2 0 Alternative splicing regulator C2 PF00168.30 CDI84376.1 - 4.3e-06 27.0 0.0 7.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain ABC1 PF03109.16 CDI84377.1 - 3.4e-31 107.9 0.2 9.9e-31 106.4 0.2 1.8 1 0 0 1 1 1 1 ABC1 family DEAD PF00270.29 CDI84377.1 - 2.8e-09 37.0 0.5 7e-08 32.4 0.5 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase RIO1 PF01163.22 CDI84377.1 - 0.08 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Ribonuc_P_40 PF08584.11 CDI84379.1 - 0.0044 16.3 0.0 0.0063 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit AAA_23 PF13476.6 CDI84380.1 - 5.5e-05 23.8 0.0 7.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDI84380.1 - 0.015 15.1 0.1 0.062 13.1 0.0 2.0 1 1 1 2 2 2 0 P-loop containing region of AAA domain MukB PF04310.12 CDI84380.1 - 0.017 14.9 0.1 0.029 14.2 0.1 1.2 1 0 0 1 1 1 0 MukB N-terminal SMC_N PF02463.19 CDI84380.1 - 0.087 12.2 0.0 0.23 10.9 0.0 1.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Metallophos PF00149.28 CDI84381.1 - 3.1e-06 27.9 0.0 9.7e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Mucin-like PF16058.5 CDI84381.1 - 1.7 8.8 7.9 2.7 8.1 7.9 1.3 1 0 0 1 1 1 0 Mucin-like TPR_1 PF00515.28 CDI84382.1 - 3.4e-13 48.8 6.0 0.00014 21.5 0.4 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDI84382.1 - 1.8e-12 46.3 4.2 0.0092 16.0 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDI84382.1 - 6.3e-11 41.6 0.3 0.086 13.1 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDI84382.1 - 9.6e-09 34.7 0.0 0.087 12.9 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI84382.1 - 2.1e-07 31.2 2.1 0.27 12.1 0.1 4.4 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 CDI84382.1 - 6.6e-07 29.4 3.3 0.0022 18.1 0.7 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDI84382.1 - 9.2e-07 28.3 0.0 1.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDI84382.1 - 1e-06 29.1 0.2 0.31 11.6 0.0 3.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDI84382.1 - 6.2e-06 26.5 0.2 0.99 10.2 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDI84382.1 - 1.3e-05 25.2 0.1 4.3 8.0 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDI84382.1 - 0.00019 21.0 0.4 2.8 7.7 0.0 4.6 4 1 1 5 5 5 1 TPR repeat TPR_12 PF13424.6 CDI84382.1 - 0.00095 19.4 1.3 3.2 8.1 0.0 3.4 1 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDI84382.1 - 0.0079 16.8 6.7 0.026 15.2 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDI84382.1 - 0.058 13.6 1.9 1.4 9.2 0.5 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 CDI84382.1 - 0.17 12.3 1.1 16 5.9 0.2 2.6 2 1 1 3 3 3 0 Bacterial transcriptional activator domain RPN7 PF10602.9 CDI84382.1 - 0.19 11.4 0.1 3.1 7.5 0.1 2.1 2 0 0 2 2 2 0 26S proteasome subunit RPN7 RskA PF10099.9 CDI84383.1 - 0.00062 20.1 10.7 0.00062 20.1 10.7 15.8 7 4 4 12 12 12 3 Anti-sigma-K factor rskA TrmE_N PF10396.9 CDI84385.1 - 3.6e-20 72.4 0.0 2.7e-13 50.3 0.0 3.8 2 1 0 2 2 2 2 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CDI84385.1 - 3.8e-16 59.2 0.0 1.1e-15 57.7 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Med15 PF09606.10 CDI84385.1 - 0.00023 20.0 31.1 0.00023 20.0 31.1 3.7 3 1 0 3 3 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal SR-25 PF10500.9 CDI84385.1 - 0.00053 19.7 4.8 0.00053 19.7 4.8 5.5 6 0 0 6 6 6 1 Nuclear RNA-splicing-associated protein DUF2722 PF10846.8 CDI84385.1 - 0.0016 17.5 1.3 0.0016 17.5 1.3 5.7 5 1 0 5 5 4 1 Protein of unknown function (DUF2722) Secretin_N_2 PF07655.13 CDI84385.1 - 0.0055 17.2 5.5 0.0055 17.2 5.5 5.1 4 1 0 4 4 2 1 Secretin N-terminal domain Histone_HNS PF00816.21 CDI84385.1 - 0.024 15.4 0.7 0.024 15.4 0.7 6.1 6 1 0 6 6 4 0 H-NS histone family SUIM_assoc PF16619.5 CDI84385.1 - 0.031 14.3 0.0 0.031 14.3 0.0 8.4 6 3 1 7 7 4 0 Unstructured region C-term to UIM in Ataxin3 FeoB_N PF02421.18 CDI84385.1 - 0.034 13.7 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B SRPRB PF09439.10 CDI84385.1 - 0.035 13.5 0.0 2.1 7.8 0.0 2.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CDI84385.1 - 0.67 9.8 0.0 0.67 9.8 0.0 3.3 4 0 0 4 4 4 0 RsgA GTPase Pkinase PF00069.25 CDI84386.1 - 3.2e-11 43.1 0.1 2.5e-08 33.6 0.0 3.5 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84386.1 - 3.6e-05 23.2 1.6 0.0005 19.4 0.0 2.8 3 0 0 3 3 3 1 Protein tyrosine kinase SUIM_assoc PF16619.5 CDI84386.1 - 0.0096 16.0 0.3 0.0096 16.0 0.3 10.1 6 2 3 9 9 9 1 Unstructured region C-term to UIM in Ataxin3 S10_plectin PF03501.15 CDI84387.1 - 2.2e-40 136.6 0.3 2.7e-40 136.3 0.3 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF384 PF04064.13 CDI84388.1 - 0.1 12.4 0.1 0.28 11.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF384) zf-B_box PF00643.24 CDI84390.1 - 4.2e-05 23.6 3.7 4.2e-05 23.6 3.7 3.7 4 1 0 4 4 4 1 B-box zinc finger IBR PF01485.21 CDI84390.1 - 0.0056 16.9 0.5 0.0056 16.9 0.5 3.1 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain Presenilin PF01080.17 CDI84390.1 - 0.69 8.6 6.8 0.15 10.8 1.1 2.1 2 0 0 2 2 2 0 Presenilin PEHE PF15275.6 CDI84390.1 - 1.3 9.6 9.3 2.9 8.5 0.4 2.7 3 0 0 3 3 3 0 PEHE domain Pkinase PF00069.25 CDI84392.1 - 3.5e-06 26.6 0.0 9.8e-06 25.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDI84392.1 - 0.0017 17.7 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF2572 PF10833.8 CDI84392.1 - 0.16 11.7 1.0 15 5.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2572) DUF1681 PF07933.14 CDI84392.1 - 0.24 11.1 3.3 0.13 11.9 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1681) Presenilin PF01080.17 CDI84403.1 - 0.00068 18.5 21.0 0.00075 18.4 21.0 1.2 1 0 0 1 1 1 1 Presenilin O-antigen_lig PF13425.6 CDI84403.1 - 0.0015 17.4 3.6 0.0019 17.0 3.6 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Zip PF02535.22 CDI84403.1 - 0.0028 16.9 10.1 0.0034 16.7 10.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter CDC45 PF02724.14 CDI84403.1 - 0.011 14.1 20.7 0.011 14.1 20.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.13 CDI84403.1 - 0.068 13.2 45.2 0.079 12.9 45.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 CDI84403.1 - 0.07 13.2 13.5 0.078 13.0 13.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Trypan_PARP PF05887.11 CDI84403.1 - 0.25 11.3 5.6 0.39 10.7 5.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) V_ATPase_I PF01496.19 CDI84403.1 - 0.26 9.2 18.5 0.3 8.9 18.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CDI84403.1 - 0.37 10.6 27.7 0.46 10.3 27.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PA26 PF04636.13 CDI84403.1 - 0.46 9.4 17.9 0.51 9.2 17.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Lin-8 PF03353.15 CDI84403.1 - 0.6 9.6 27.3 0.7 9.4 27.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM60A PF15396.6 CDI84403.1 - 0.72 9.8 17.5 0.87 9.6 17.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Membralin PF09746.9 CDI84403.1 - 0.86 8.6 12.1 0.99 8.4 12.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein CCSAP PF15748.5 CDI84403.1 - 1 9.5 26.9 1.1 9.4 26.9 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Velvet PF11754.8 CDI84403.1 - 1.4 8.8 16.2 2 8.3 16.2 1.2 1 0 0 1 1 1 0 Velvet factor DUF4746 PF15928.5 CDI84403.1 - 1.5 8.2 25.2 2 7.7 25.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HAUS6_N PF14661.6 CDI84403.1 - 2.2 7.8 21.7 2.5 7.6 21.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus MMR1 PF08505.10 CDI84403.1 - 2.3 8.4 25.8 2.9 8.1 25.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Smg8_Smg9 PF10220.9 CDI84403.1 - 3.3 5.9 22.3 3.5 5.8 22.3 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF913 PF06025.12 CDI84403.1 - 3.7 6.4 15.8 5.2 5.9 15.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) HCO3_cotransp PF00955.21 CDI84403.1 - 4.5 6.0 6.9 5.1 5.8 6.9 1.2 1 0 0 1 1 1 0 HCO3- transporter family SLC12 PF03522.15 CDI84403.1 - 4.7 6.1 25.9 5.1 6.0 25.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4045 PF13254.6 CDI84403.1 - 4.9 6.7 24.7 5.4 6.6 24.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) GAGA_bind PF06217.12 CDI84403.1 - 5.6 7.2 19.3 6.8 6.9 19.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_11 PF13086.6 CDI84403.1 - 5.8 6.6 23.5 7 6.3 23.5 1.1 1 0 0 1 1 1 0 AAA domain PPP4R2 PF09184.11 CDI84403.1 - 6.8 6.2 24.6 7.9 6.0 24.6 1.1 1 0 0 1 1 1 0 PPP4R2 eIF-3_zeta PF05091.12 CDI84403.1 - 7.1 5.5 26.7 10 5.0 26.7 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Paf1 PF03985.13 CDI84403.1 - 7.2 5.5 33.6 9.6 5.1 33.6 1.2 1 0 0 1 1 1 0 Paf1 Hid1 PF12722.7 CDI84403.1 - 7.8 4.5 25.2 8.1 4.4 25.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 CDI84403.1 - 7.9 5.1 23.0 8.7 5.0 23.0 1.0 1 0 0 1 1 1 0 Raftlin SNF2_N PF00176.23 CDI84404.1 - 5.9e-56 189.7 0.3 5.9e-56 189.7 0.3 4.0 2 1 2 4 4 4 1 SNF2 family N-terminal domain Chromo PF00385.24 CDI84404.1 - 2.5e-15 56.1 1.7 5.6e-08 32.6 0.2 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Macoilin PF09726.9 CDI84404.1 - 0.0018 16.9 2.6 0.0018 16.9 2.6 5.2 3 2 1 4 4 4 1 Macoilin family DUF1310 PF07006.11 CDI84404.1 - 0.0047 16.9 0.3 0.023 14.7 0.3 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1310) TFIIA PF03153.13 CDI84404.1 - 0.006 16.6 25.0 0.006 16.6 25.0 5.4 2 1 2 4 4 4 2 Transcription factor IIA, alpha/beta subunit ATP-synt_ab PF00006.25 CDI84408.1 - 2.6e-61 207.0 0.0 4.1e-61 206.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDI84408.1 - 5.8e-21 74.8 0.7 1.3e-20 73.7 0.7 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_16 PF13191.6 CDI84408.1 - 0.0011 19.4 0.0 0.0095 16.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain RskA PF10099.9 CDI84408.1 - 0.0026 18.1 9.3 0.0064 16.8 9.3 1.6 1 0 0 1 1 1 1 Anti-sigma-K factor rskA RnfC_N PF13375.6 CDI84408.1 - 0.0027 17.6 0.5 0.0067 16.4 0.5 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain NB-ARC PF00931.22 CDI84408.1 - 0.0087 15.3 0.4 0.019 14.1 0.2 1.6 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 CDI84408.1 - 0.011 16.1 2.2 0.38 11.2 0.0 3.4 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CDI84408.1 - 0.013 14.9 0.6 0.033 13.5 0.6 1.7 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 CDI84408.1 - 0.049 13.5 0.6 0.27 11.1 0.6 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RsgA_GTPase PF03193.16 CDI84408.1 - 0.065 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase OMP_b-brl PF13505.6 CDI84408.1 - 0.11 12.6 4.7 0.74 9.9 1.0 2.2 2 0 0 2 2 2 0 Outer membrane protein beta-barrel domain ATPase_2 PF01637.18 CDI84408.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Roc PF08477.13 CDI84408.1 - 0.19 12.0 0.4 0.51 10.6 0.4 1.8 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 CDI84408.1 - 0.19 11.6 1.4 0.5 10.3 0.1 2.1 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 CDI84408.1 - 0.21 12.0 0.0 0.51 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 CDI84408.1 - 0.41 11.2 2.1 0.49 10.9 0.2 2.0 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 CDI84408.1 - 0.8 10.0 5.9 0.33 11.3 0.2 2.7 3 0 0 3 3 3 0 AAA domain FAM60A PF15396.6 CDI84409.1 - 0.37 10.7 8.5 0.49 10.4 8.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A HflK_N PF12221.8 CDI84410.1 - 0.064 13.3 0.3 0.064 13.3 0.3 3.6 4 1 0 4 4 4 0 Bacterial membrane protein N terminal CRT10 PF08728.10 CDI84410.1 - 0.73 7.9 3.8 1 7.4 3.8 1.2 1 0 0 1 1 1 0 CRT10 LMBR1 PF04791.16 CDI84410.1 - 2 7.2 12.5 3.4 6.5 6.7 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein Ebp2 PF05890.12 CDI84411.1 - 7.2e-30 104.4 1.0 1.1e-29 103.8 1.0 1.2 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Gly-rich_Ago1 PF12764.7 CDI84411.1 - 7.6 7.4 9.3 0.26 12.1 1.9 2.3 2 0 0 2 2 2 0 Glycine-rich region of argonaut XRCC4 PF06632.12 CDI84412.1 - 0.9 8.3 28.5 1.1 8.0 28.5 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Presenilin PF01080.17 CDI84412.1 - 1.7 7.3 38.6 2.8 6.6 38.6 1.3 1 0 0 1 1 1 0 Presenilin PCM1_C PF15717.5 CDI84412.1 - 7.8 5.1 33.8 8.5 4.9 33.8 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Neur_chan_memb PF02932.16 CDI84412.1 - 10 6.1 30.4 14 5.7 30.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 CDI84413.1 - 0.0044 16.7 22.7 0.0044 16.7 22.7 1.0 1 0 0 1 1 1 1 Spt20 family DUF2722 PF10846.8 CDI84413.1 - 0.014 14.4 15.7 0.014 14.4 15.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI84413.1 - 0.94 9.4 21.9 1 9.3 21.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 CDI84413.1 - 7.7 5.2 7.6 7.2 5.3 7.6 1.1 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 CDI84414.1 - 0.00019 21.8 16.4 0.00019 21.8 16.4 2.0 1 1 1 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated DUF4207 PF13904.6 CDI84414.1 - 0.0015 18.3 41.4 0.002 17.9 41.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Isy1 PF06246.12 CDI84414.1 - 0.1 12.2 21.8 0.13 11.9 21.8 1.2 1 0 0 1 1 1 0 Isy1-like splicing family UPF0564 PF10595.9 CDI84414.1 - 0.17 10.9 36.6 0.21 10.6 36.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 SOBP PF15279.6 CDI84414.1 - 0.7 10.4 24.3 0.9 10.1 24.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein TFIIA PF03153.13 CDI84414.1 - 0.85 9.5 56.0 1.2 9.1 56.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 CDI84414.1 - 1.5 7.7 31.0 1.8 7.5 31.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ABC2_membrane_2 PF12679.7 CDI84414.1 - 1.5 8.0 4.0 2.8 7.1 4.0 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4407 PF14362.6 CDI84414.1 - 3.2 7.0 28.2 4.3 6.6 28.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PAT1 PF09770.9 CDI84414.1 - 3.5 5.8 40.6 4.2 5.5 40.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprA-related PF12118.8 CDI84414.1 - 3.8 6.6 49.0 5.4 6.1 49.0 1.1 1 0 0 1 1 1 0 SprA-related family Dynactin_p62 PF05502.13 CDI84414.1 - 4.3 6.0 18.0 5.5 5.7 18.0 1.0 1 0 0 1 1 1 0 Dynactin p62 family DUF5523 PF17661.1 CDI84414.1 - 5.7 6.5 26.4 7.2 6.2 26.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) AF-4 PF05110.13 CDI84414.1 - 7 4.6 35.8 8.8 4.3 35.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Nop53 PF07767.11 CDI84414.1 - 7.6 5.8 34.5 11 5.3 34.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) N6_N4_Mtase PF01555.18 CDI84414.1 - 7.8 6.1 8.2 10 5.7 8.2 1.2 1 0 0 1 1 1 0 DNA methylase TFIIA PF03153.13 CDI84415.1 - 3.9 7.4 10.6 3.8 7.4 10.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDI84415.1 - 5.4 6.6 11.0 5.6 6.5 11.0 1.1 1 0 0 1 1 1 0 Spt20 family Stathmin PF00836.19 CDI84416.1 - 1.3 9.0 11.6 2.3 8.2 9.4 2.5 2 0 0 2 2 2 0 Stathmin family Ras PF00071.22 CDI84421.1 - 6e-25 87.7 0.4 1.2e-24 86.7 0.4 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDI84421.1 - 4.1e-05 23.8 0.0 9.9e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SPX PF03105.19 CDI84421.1 - 0.0011 18.9 17.0 0.0013 18.8 17.0 1.1 1 0 0 1 1 1 1 SPX domain Apt1 PF10351.9 CDI84421.1 - 0.0075 15.2 17.9 0.0082 15.1 17.9 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain NPR3 PF03666.13 CDI84421.1 - 0.011 14.6 9.5 0.013 14.3 9.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Arf PF00025.21 CDI84421.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family PAP1 PF08601.10 CDI84421.1 - 0.02 14.7 20.2 0.022 14.5 20.2 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 FAM76 PF16046.5 CDI84421.1 - 0.024 14.0 9.2 0.032 13.6 9.2 1.2 1 0 0 1 1 1 0 FAM76 protein Velvet PF11754.8 CDI84421.1 - 0.048 13.6 10.1 0.086 12.8 10.1 1.4 1 0 0 1 1 1 0 Velvet factor Miga PF10265.9 CDI84421.1 - 0.049 12.6 15.5 0.058 12.4 15.5 1.0 1 0 0 1 1 1 0 Mitoguardin Macoilin PF09726.9 CDI84421.1 - 0.066 11.8 21.4 0.09 11.3 21.4 1.3 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CDI84421.1 - 0.11 11.2 9.8 0.13 11.0 9.8 1.3 1 0 0 1 1 1 0 Presenilin FeoB_N PF02421.18 CDI84421.1 - 0.18 11.3 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B Tmemb_cc2 PF10267.9 CDI84421.1 - 3.3 6.7 17.4 4.4 6.3 17.4 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Pannexin_like PF12534.8 CDI84421.1 - 4 6.4 8.3 6 5.8 8.3 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 MAP70 PF07058.11 CDI84421.1 - 4.3 6.0 17.1 5.4 5.6 17.1 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Peptidase_S64 PF08192.11 CDI84421.1 - 6.1 5.2 18.0 7.3 5.0 18.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 Band_3_cyto PF07565.13 CDI84421.1 - 6.2 6.6 9.0 10 5.9 9.0 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Zip PF02535.22 CDI84421.1 - 7.6 5.6 15.3 0.35 10.1 9.8 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter MMU163 PF17119.5 CDI84421.1 - 8.1 5.5 13.2 1.3e+02 1.6 13.2 2.2 1 1 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis GEMIN8 PF15348.6 CDI84421.1 - 8.2 6.7 17.0 12 6.1 17.0 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 CDK2AP PF09806.9 CDI84423.1 - 0.31 11.1 24.1 0.4 10.7 24.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Opi1 PF08618.10 CDI84423.1 - 0.37 10.0 17.0 0.41 9.9 17.0 1.0 1 0 0 1 1 1 0 Transcription factor Opi1 SR-25 PF10500.9 CDI84423.1 - 0.46 10.0 31.0 46 3.5 31.0 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4667 PF15700.5 CDI84423.1 - 0.65 10.1 24.0 0.79 9.8 24.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Rtf2 PF04641.12 CDI84423.1 - 1.1 8.5 15.5 1.3 8.4 15.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger MAP65_ASE1 PF03999.12 CDI84423.1 - 3.1 6.4 26.3 3.5 6.2 26.3 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Menin PF05053.13 CDI84423.1 - 6.4 5.0 15.8 7.1 4.8 15.8 1.0 1 0 0 1 1 1 0 Menin Folliculin PF11704.8 CDI84423.1 - 6.5 6.6 13.4 8.9 6.2 13.4 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport TFIIA PF03153.13 CDI84423.1 - 7.2 6.5 42.5 10 6.0 42.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CIAPIN1 PF05093.13 CDI84423.1 - 7.4 7.1 11.9 0.81 10.2 3.6 2.1 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Mito_fiss_reg PF05308.11 CDI84423.1 - 9.1 6.3 23.6 11 6.1 23.6 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Totivirus_coat PF05518.11 CDI84423.1 - 9.2 4.2 13.0 11 3.9 13.0 1.0 1 0 0 1 1 1 0 Totivirus coat protein Macoilin PF09726.9 CDI84423.1 - 9.4 4.7 19.8 10 4.5 19.8 1.0 1 0 0 1 1 1 0 Macoilin family ATP-synt_F PF01990.17 CDI84424.1 - 5.7e-14 52.2 0.1 1.6e-13 50.7 0.1 1.8 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit TFIIA PF03153.13 CDI84424.1 - 0.00027 21.1 25.4 0.00027 21.1 25.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CDI84424.1 - 0.005 17.5 18.0 0.0095 16.6 18.0 1.5 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DDHD PF02862.17 CDI84424.1 - 0.014 15.6 6.2 0.015 15.5 6.2 1.2 1 0 0 1 1 1 0 DDHD domain DUF5427 PF10310.9 CDI84424.1 - 0.023 13.7 21.3 0.03 13.3 21.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Presenilin PF01080.17 CDI84424.1 - 0.078 11.7 15.2 0.096 11.4 15.2 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 CDI84424.1 - 0.1 11.3 8.2 0.1 11.3 8.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Cellulose_synt PF03552.14 CDI84424.1 - 0.1 11.1 1.8 0.12 10.9 1.8 1.1 1 0 0 1 1 1 0 Cellulose synthase CDC45 PF02724.14 CDI84424.1 - 0.16 10.2 11.7 0.18 10.0 11.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2076 PF09849.9 CDI84424.1 - 0.23 11.5 27.5 0.32 11.0 27.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4746 PF15928.5 CDI84424.1 - 0.33 10.3 7.7 0.38 10.1 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF3292 PF11696.8 CDI84424.1 - 0.41 8.9 8.9 0.55 8.5 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) SARAF PF06682.12 CDI84424.1 - 0.5 10.0 21.1 2.9 7.5 17.1 2.1 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Zip PF02535.22 CDI84424.1 - 0.61 9.2 5.2 0.81 8.8 5.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter V_ATPase_I PF01496.19 CDI84424.1 - 0.64 7.9 11.1 0.66 7.8 11.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 CDI84424.1 - 1 8.1 13.7 1.2 7.8 13.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MMR1 PF08505.10 CDI84424.1 - 1.9 8.7 22.9 2.5 8.3 22.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein FAM91_C PF14648.6 CDI84424.1 - 2 7.1 7.4 2.5 6.8 7.4 1.1 1 0 0 1 1 1 0 FAM91 C-terminus LAP1C PF05609.12 CDI84424.1 - 2.6 7.0 18.9 3.2 6.7 18.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 CDI84424.1 - 3 4.8 17.8 3.7 4.6 17.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3138 PF11336.8 CDI84424.1 - 6.8 5.2 12.5 8.5 4.9 12.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) PAT1 PF09770.9 CDI84424.1 - 8.3 4.5 28.6 9.4 4.4 28.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Uteroglobin PF01099.17 CDI84425.1 - 6.4 7.2 7.0 4.7 7.6 3.8 2.6 2 0 0 2 2 2 0 Uteroglobin family COX6B PF02297.17 CDI84428.1 - 0.00016 21.8 5.0 0.00034 20.8 5.0 1.5 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb RCC1 PF00415.18 CDI84430.1 - 5.3e-30 103.8 19.4 1.4e-08 35.2 0.1 7.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDI84430.1 - 7.1e-14 51.2 26.9 0.00089 19.0 0.2 6.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat zf-RanBP PF00641.18 CDI84430.1 - 0.21 10.9 12.8 0.03 13.7 8.5 1.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Ribosomal_L5_C PF00673.21 CDI84434.1 - 2.5e-22 78.9 0.0 3.9e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CDI84434.1 - 2.6e-21 75.7 0.0 5.1e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 V-SNARE_C PF12352.8 CDI84434.1 - 0.1 12.9 0.3 0.39 11.1 0.1 1.9 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus HTH_ABP1_N PF18107.1 CDI84434.1 - 0.16 11.7 1.4 0.19 11.5 0.1 1.7 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain ADH_zinc_N PF00107.26 CDI84435.1 - 1.8e-24 86.1 0.1 2.7e-24 85.6 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDI84435.1 - 2e-10 40.5 8.2 5.9e-10 39.0 8.2 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 CDI84435.1 - 9.1e-05 22.0 0.1 0.00013 21.5 0.1 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 CDI84435.1 - 0.001 18.7 0.2 0.0015 18.2 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 CDI84435.1 - 0.0012 18.2 0.5 0.0018 17.6 0.2 1.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CDI84435.1 - 0.19 11.0 0.5 0.62 9.4 0.1 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TipAS PF07739.13 CDI84437.1 - 0.053 14.1 0.0 1 10.0 0.0 2.4 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Candida_ALS PF05792.13 CDI84437.1 - 1 10.0 7.3 6.7 7.4 7.3 2.5 1 0 0 1 1 1 0 Candida agglutinin-like (ALS) Nop14 PF04147.12 CDI84437.1 - 1 7.5 8.9 1.8 6.7 8.9 1.3 1 0 0 1 1 1 0 Nop14-like family Pkinase PF00069.25 CDI84439.1 - 5.2e-48 163.7 0.7 3.2e-41 141.5 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84439.1 - 5.3e-25 88.2 0.1 8e-25 87.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDI84439.1 - 2e-06 27.3 0.1 3.1e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDI84439.1 - 3.7e-05 23.2 0.0 0.0052 16.1 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 CDI84439.1 - 0.0013 18.7 0.0 0.64 9.9 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Cytokin-bind PF09265.10 CDI84439.1 - 0.076 12.4 0.0 0.16 11.3 0.0 1.5 2 0 0 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding RRM_1 PF00076.22 CDI84440.1 - 6e-18 64.4 0.1 8.3e-18 64.0 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDI84440.1 - 0.044 13.8 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Sigma54_CBD PF04963.13 CDI84442.1 - 0.029 14.2 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain DUF1864 PF08933.11 CDI84442.1 - 0.084 11.6 0.0 0.18 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1864) Porin_3 PF01459.22 CDI84444.1 - 1.2e-16 61.0 0.1 2.6e-16 59.9 0.1 1.7 1 1 0 1 1 1 1 Eukaryotic porin DUF3645 PF12359.8 CDI84444.1 - 0.049 13.0 1.1 0.43 10.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3645) NIF PF03031.18 CDI84445.1 - 1.5e-15 57.3 0.0 2.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ndc1_Nup PF09531.10 CDI84445.1 - 3.3 6.3 4.1 3.9 6.0 4.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2992 PF11208.8 CDI84445.1 - 5.1 7.3 12.1 10 6.4 12.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Hamartin PF04388.12 CDI84445.1 - 9.7 4.7 12.3 13 4.3 12.3 1.1 1 0 0 1 1 1 0 Hamartin protein PP2C PF00481.21 CDI84448.1 - 0.041 13.5 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein phosphatase 2C Apt1 PF10351.9 CDI84448.1 - 0.63 8.8 5.1 0.71 8.7 5.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CRISPR_Cse2 PF09485.10 CDI84448.1 - 4.6 7.8 14.1 0.27 11.7 6.3 2.1 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) IMUP PF15761.5 CDI84448.1 - 6.1 7.6 30.2 0.96 10.2 1.5 3.4 2 1 1 3 3 3 0 Immortalisation up-regulated protein PAT1 PF09770.9 CDI84449.1 - 1.1 7.5 45.8 1.6 6.9 45.8 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4776 PF16003.5 CDI84449.1 - 2.6 6.9 32.9 3.9 6.4 32.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Activator_LAG-3 PF11498.8 CDI84449.1 - 2.7 6.9 78.2 15 4.4 74.9 2.3 2 0 0 2 2 2 0 Transcriptional activator LAG-3 DUF3584 PF12128.8 CDI84449.1 - 4.1 4.8 46.3 5.4 4.4 46.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AF-4 PF05110.13 CDI84449.1 - 4.1 5.4 56.0 0.047 11.8 39.9 2.2 2 0 0 2 2 2 0 AF-4 proto-oncoprotein FapA PF03961.13 CDI84449.1 - 9.9 4.6 18.5 14 4.1 18.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Fasciclin PF02469.22 CDI84451.1 - 2.5e-10 40.7 8.6 2.6e-06 27.7 1.9 3.2 2 1 1 3 3 3 2 Fasciclin domain Neur_chan_memb PF02932.16 CDI84451.1 - 0.00035 20.7 1.7 0.00042 20.4 1.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PTPRCAP PF15713.5 CDI84451.1 - 0.00097 19.4 8.4 0.0024 18.2 8.4 1.6 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated Coilin_N PF15862.5 CDI84451.1 - 0.0014 18.4 7.6 0.0022 17.8 7.6 1.3 1 0 0 1 1 1 1 Coilin N-terminus SpoIIP PF07454.11 CDI84451.1 - 0.0017 17.9 7.0 0.0023 17.5 7.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Peroxin-3 PF04882.12 CDI84451.1 - 0.0029 16.7 9.1 0.0044 16.1 9.1 1.2 1 0 0 1 1 1 1 Peroxin-3 AIF_C PF14721.6 CDI84451.1 - 0.0043 17.4 3.6 0.0071 16.7 3.6 1.3 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Presenilin PF01080.17 CDI84451.1 - 0.0076 15.1 12.3 0.01 14.6 12.3 1.1 1 0 0 1 1 1 1 Presenilin Velvet PF11754.8 CDI84451.1 - 0.018 15.0 10.4 0.033 14.1 10.4 1.4 1 0 0 1 1 1 0 Velvet factor EPL1 PF10513.9 CDI84451.1 - 0.029 14.7 11.3 0.054 13.9 11.3 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like MCU PF04678.13 CDI84451.1 - 0.031 14.4 6.8 0.045 13.8 3.7 2.1 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF1764 PF08576.10 CDI84451.1 - 0.034 15.0 6.7 0.063 14.2 6.7 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Tim54 PF11711.8 CDI84451.1 - 0.043 12.6 8.9 0.077 11.8 8.9 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 CDI84451.1 - 0.045 13.9 8.8 0.09 13.0 8.8 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal MCD PF05292.11 CDI84451.1 - 0.068 12.7 3.7 0.083 12.4 1.5 1.9 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain SID-1_RNA_chan PF13965.6 CDI84451.1 - 0.086 11.2 0.1 0.082 11.3 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4471 PF14740.6 CDI84451.1 - 0.1 11.8 6.6 0.074 12.3 5.2 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4471) Endostatin PF06482.11 CDI84451.1 - 0.11 12.0 12.4 0.028 13.9 9.5 1.5 2 0 0 2 2 1 0 Collagenase NC10 and Endostatin Baculo_gp41 PF04700.12 CDI84451.1 - 0.11 12.2 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region Gti1_Pac2 PF09729.9 CDI84451.1 - 0.13 12.3 9.5 0.2 11.7 9.5 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family RR_TM4-6 PF06459.12 CDI84451.1 - 0.15 11.9 12.4 0.25 11.2 12.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2126 PF09899.9 CDI84451.1 - 0.21 9.6 9.6 0.31 9.0 9.6 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) GREB1 PF15782.5 CDI84451.1 - 0.25 8.4 9.8 0.32 8.1 9.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S49_N PF08496.10 CDI84451.1 - 0.29 11.2 8.7 0.52 10.4 8.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pex14_N PF04695.13 CDI84451.1 - 0.46 11.1 28.2 0.044 14.5 20.9 2.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Folate_carrier PF01770.18 CDI84451.1 - 0.52 9.0 7.5 0.87 8.2 7.5 1.3 1 0 0 1 1 1 0 Reduced folate carrier SelP_N PF04592.14 CDI84451.1 - 0.6 9.5 27.9 1 8.7 27.9 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ndc1_Nup PF09531.10 CDI84451.1 - 0.63 8.7 6.8 1 8.0 6.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 CDI84451.1 - 0.65 8.2 10.3 0.92 7.7 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 CDI84451.1 - 0.8 9.4 15.0 1.2 8.8 15.0 1.2 1 0 0 1 1 1 0 Connexin BORG_CEP PF14957.6 CDI84451.1 - 0.82 10.8 11.7 0.62 11.2 8.8 1.9 2 0 0 2 2 2 0 Cdc42 effector DUF1980 PF09323.10 CDI84451.1 - 0.9 9.4 5.1 1.7 8.5 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Serinc PF03348.15 CDI84451.1 - 0.98 8.3 4.4 1.4 7.8 4.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Med15 PF09606.10 CDI84451.1 - 1 8.0 42.6 1.5 7.4 42.6 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SLC12 PF03522.15 CDI84451.1 - 1.3 8.0 13.9 2 7.4 13.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF3043 PF11241.8 CDI84451.1 - 1.5 8.8 8.5 3.3 7.7 8.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) OATP PF03137.20 CDI84451.1 - 1.7 6.8 7.0 3.5 5.8 7.0 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3292 PF11696.8 CDI84451.1 - 1.9 6.8 9.9 2.9 6.2 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) FAM60A PF15396.6 CDI84451.1 - 2 8.4 10.6 3.1 7.8 10.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A V_ATPase_I PF01496.19 CDI84451.1 - 2.3 6.0 17.7 3.2 5.6 17.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Membralin PF09746.9 CDI84451.1 - 2.4 7.1 7.6 3.5 6.6 7.6 1.2 1 0 0 1 1 1 0 Tumour-associated protein WASH-7_C PF14746.6 CDI84451.1 - 2.6 7.7 13.7 5 6.8 13.7 1.4 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal TERB2 PF15101.6 CDI84451.1 - 2.9 7.9 22.0 4.8 7.2 20.4 1.8 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CobT PF06213.12 CDI84451.1 - 3 7.1 25.0 6.1 6.1 25.0 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CLN3 PF02487.17 CDI84451.1 - 3.8 6.4 12.0 5.9 5.8 12.0 1.2 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 CDI84451.1 - 4 6.1 13.4 6.2 5.5 13.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM31_MDM32 PF08118.11 CDI84451.1 - 4.2 5.9 7.9 5.6 5.5 7.9 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Peptidase_U57 PF05582.12 CDI84451.1 - 4.6 6.4 10.7 7.4 5.7 10.7 1.2 1 0 0 1 1 1 0 YabG peptidase U57 DUF4175 PF13779.6 CDI84451.1 - 4.6 5.0 45.1 2.6 5.9 40.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) U3_snoRNA_assoc PF08297.11 CDI84451.1 - 4.7 8.0 11.8 2.4 9.0 9.1 1.8 2 0 0 2 2 1 0 U3 snoRNA associated FAM176 PF14851.6 CDI84451.1 - 5.3 6.7 9.3 11 5.7 9.3 1.5 1 0 0 1 1 1 0 FAM176 family Baculo_PP31 PF05311.11 CDI84451.1 - 5.5 6.4 12.6 7.9 5.9 12.6 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF2828 PF11443.8 CDI84451.1 - 5.7 4.9 16.1 8.1 4.4 16.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PIP5K PF01504.18 CDI84451.1 - 5.8 6.1 14.3 9.1 5.4 14.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Sec62 PF03839.16 CDI84451.1 - 7 6.1 10.9 12 5.3 10.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4638 PF15472.6 CDI84451.1 - 7.1 6.3 13.8 37 3.9 14.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) AUX_IAA PF02309.16 CDI84451.1 - 7.3 6.4 9.5 16 5.3 9.1 1.6 2 0 0 2 2 2 0 AUX/IAA family Endonuc_Holl PF10107.9 CDI84451.1 - 7.8 6.3 9.6 13 5.6 9.6 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase CSG2 PF16965.5 CDI84451.1 - 8 5.3 7.8 12 4.7 7.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator EIIBC-GUT_N PF03612.14 CDI84451.1 - 8.4 6.1 12.9 16 5.2 12.9 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Macoilin PF09726.9 CDI84451.1 - 8.4 4.8 14.2 15 3.9 14.2 1.3 1 0 0 1 1 1 0 Macoilin family Ctr PF04145.15 CDI84451.1 - 8.8 6.9 10.6 21 5.7 10.6 1.6 1 0 0 1 1 1 0 Ctr copper transporter family MMM1 PF10296.9 CDI84451.1 - 9.3 5.2 9.7 13 4.7 9.7 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF1387 PF07139.11 CDI84452.1 - 0.34 10.6 9.2 0.53 10.0 9.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DLIC PF05783.11 CDI84452.1 - 0.57 8.9 13.6 0.81 8.4 13.6 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Plasmodium_Vir PF05795.11 CDI84452.1 - 0.72 9.2 4.7 0.87 8.9 4.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TFIIA PF03153.13 CDI84452.1 - 0.87 9.5 18.1 1 9.2 18.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 CDI84452.1 - 1.6 8.2 10.7 2 7.9 10.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SPX PF03105.19 CDI84452.1 - 1.8 8.4 17.5 2.4 8.0 17.5 1.1 1 0 0 1 1 1 0 SPX domain Hamartin PF04388.12 CDI84452.1 - 3.4 6.2 10.9 4.1 6.0 10.9 1.1 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 CDI84452.1 - 3.8 4.5 14.5 4.1 4.4 14.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cwf_Cwc_15 PF04889.12 CDI84452.1 - 8.5 6.0 10.8 4.1 7.1 8.8 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Utp14 PF04615.13 CDI84452.1 - 9.3 4.7 15.1 11 4.5 15.1 1.1 1 0 0 1 1 1 0 Utp14 protein Apt1 PF10351.9 CDI84453.1 - 3.5 6.4 35.7 3.7 6.3 35.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF3807 PF12720.7 CDI84453.1 - 3.9 7.7 17.2 4.9 7.4 17.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Band_3_cyto PF07565.13 CDI84453.1 - 5.7 6.7 14.7 6.3 6.5 14.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 CDI84453.1 - 9.6 6.2 14.1 10 6.1 14.1 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.13 CDI84454.1 - 1.3 9.0 12.6 1.5 8.7 12.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RAP1 PF07218.11 CDI84454.1 - 5.3 5.2 6.5 6.2 5.0 6.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) IMUP PF15761.5 CDI84454.1 - 7.9 7.2 11.5 14 6.4 11.5 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Ribosomal_S21e PF01249.18 CDI84457.1 - 6e-38 128.8 0.0 6.6e-38 128.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e NicO PF03824.16 CDI84458.1 - 1.5 8.1 12.1 2.6 7.3 12.1 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein Pkinase PF00069.25 CDI84459.1 - 1e-18 67.7 0.0 4.7e-13 49.1 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDI84459.1 - 2e-06 27.3 0.0 7.6e-05 22.1 0.0 2.5 2 1 1 3 3 3 1 Protein tyrosine kinase DUF2284 PF10050.9 CDI84460.1 - 0.023 14.4 1.8 0.054 13.2 1.8 1.6 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) TPR_1 PF00515.28 CDI84463.1 - 7.2e-10 38.3 0.5 3.3e-08 33.0 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat GFO_IDH_MocA PF01408.22 CDI84463.1 - 1.1e-07 32.7 0.0 2.6e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TPR_2 PF07719.17 CDI84463.1 - 2.1e-07 30.5 1.4 5.2e-05 23.1 0.0 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDI84463.1 - 8.3e-07 28.7 0.1 0.00011 22.1 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDI84463.1 - 1.7e-06 28.2 1.5 0.0064 16.8 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDI84463.1 - 0.00022 21.8 0.3 0.23 12.3 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDI84463.1 - 0.00037 20.3 0.5 0.99 9.6 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDI84463.1 - 0.00081 19.9 0.0 0.0023 18.4 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDI84463.1 - 0.015 15.0 0.0 0.33 10.7 0.0 2.5 1 1 1 2 2 2 0 TPR repeat TPR_16 PF13432.6 CDI84463.1 - 0.038 14.7 0.0 0.27 11.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDI84463.1 - 0.058 13.5 0.1 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 CDI84463.1 - 0.069 13.3 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Band_7 PF01145.25 CDI84466.1 - 3.6e-26 92.3 0.5 8.1e-26 91.1 0.3 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 CDI84466.1 - 0.00031 19.9 1.9 0.00041 19.5 1.9 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial Band_7_1 PF13421.6 CDI84466.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family WHAMM-JMY_N PF15920.5 CDI84466.1 - 0.081 12.8 0.5 0.21 11.5 0.5 1.6 1 0 0 1 1 1 0 N-terminal of Junction-mediating and WASP homolog-associated PAP2 PF01569.21 CDI84467.1 - 1.1e-20 73.8 3.8 1.1e-20 73.8 3.8 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CDI84467.1 - 0.0044 17.5 0.4 0.0044 17.5 0.4 2.8 3 0 0 3 3 3 1 PAP2 superfamily C-terminal DUF1682 PF07946.14 CDI84468.1 - 2.4e-52 178.2 0.0 3.2e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF2722 PF10846.8 CDI84469.1 - 0.015 14.3 0.2 0.017 14.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SPARC_Ca_bdg PF10591.9 CDI84469.1 - 0.031 14.6 1.8 0.048 14.0 1.8 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region FliD_N PF02465.18 CDI84469.1 - 1.1 10.0 5.8 4.2 8.1 1.3 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Spt20 PF12090.8 CDI84469.1 - 3.7 7.1 11.4 5.2 6.6 11.4 1.1 1 0 0 1 1 1 0 Spt20 family His_Phos_1 PF00300.22 CDI84475.1 - 1e-06 28.6 10.5 1e-06 28.6 10.5 7.5 7 1 0 7 7 7 2 Histidine phosphatase superfamily (branch 1) SUIM_assoc PF16619.5 CDI84475.1 - 0.0018 18.3 4.4 0.0018 18.3 4.4 19.0 17 2 0 17 17 17 2 Unstructured region C-term to UIM in Ataxin3 DUF3837 PF12939.7 CDI84475.1 - 0.39 11.1 4.8 0.33 11.4 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3837) Galactosyl_T PF01762.21 CDI84477.1 - 7.6e-35 120.5 0.0 2.8e-34 118.7 0.0 1.8 1 1 0 1 1 1 1 Galactosyltransferase DUF4064 PF13273.6 CDI84477.1 - 0.15 12.3 0.7 4.6 7.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) SUIM_assoc PF16619.5 CDI84477.1 - 0.16 12.1 17.0 0.68 10.0 6.0 3.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 YajC PF02699.15 CDI84477.1 - 1.2 9.1 12.1 0.38 10.7 2.8 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit RNase_Zc3h12a PF11977.8 CDI84478.1 - 0.26 11.1 4.0 2.1 8.1 0.0 3.4 3 0 0 3 3 3 0 Zc3h12a-like Ribonuclease NYN domain Transket_pyr PF02779.24 CDI84482.1 - 4.4e-44 150.3 0.0 2.3e-43 147.9 0.0 1.9 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDI84482.1 - 7.1e-33 113.1 0.0 3.2e-32 111.0 0.0 2.0 2 0 0 2 2 2 1 Transketolase, C-terminal domain MIF PF01187.18 CDI84483.1 - 3.1e-22 79.0 0.1 3.3e-22 78.9 0.1 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Barwin PF00967.17 CDI84483.1 - 0.13 12.2 0.5 0.14 12.1 0.5 1.2 1 1 0 1 1 1 0 Barwin family Copine PF07002.16 CDI84485.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Copine Tcf25 PF04910.14 CDI84486.1 - 8.3e-12 44.8 2.3 1.6e-11 43.9 2.3 1.5 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Ndc1_Nup PF09531.10 CDI84486.1 - 1.5 7.5 8.7 1.9 7.1 8.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 CDI84486.1 - 3.4 6.8 22.6 4.3 6.4 22.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SRP-alpha_N PF04086.13 CDI84486.1 - 4.9 7.0 21.1 6.7 6.5 21.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Mcm10 PF09332.11 CDI84487.1 - 1.1 8.6 6.8 0.26 10.7 3.3 1.8 2 0 0 2 2 2 0 Mcm10 replication factor GREB1 PF15782.5 CDI84487.1 - 5.1 4.1 8.2 8.9 3.3 8.2 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF755 PF05501.11 CDI84487.1 - 9.1 6.6 28.0 1.6 9.0 18.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Peptidase_C12 PF01088.21 CDI84488.1 - 6.5e-08 32.6 0.0 6.5e-08 32.6 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF2722 PF10846.8 CDI84488.1 - 0.017 14.1 1.1 0.018 14.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) La PF05383.17 CDI84490.1 - 8.6e-11 41.7 0.2 4.1e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 La domain Coilin_N PF15862.5 CDI84490.1 - 1.5e-06 28.0 1.4 1.5e-06 28.0 1.4 7.7 7 1 0 7 7 7 3 Coilin N-terminus ANAPC_CDC26 PF10471.9 CDI84490.1 - 0.0013 19.5 15.8 0.0013 19.5 15.8 10.8 8 2 2 11 11 11 3 Anaphase-promoting complex APC subunit CDC26 SR-25 PF10500.9 CDI84490.1 - 0.007 16.0 10.6 0.007 16.0 10.6 7.7 6 2 2 8 8 8 2 Nuclear RNA-splicing-associated protein Plus-3 PF03126.18 CDI84491.1 - 5e-05 23.8 0.0 0.00035 21.1 0.0 2.5 2 1 0 2 2 2 1 Plus-3 domain DUF1635 PF07795.11 CDI84491.1 - 3.4 7.5 19.3 0.58 10.0 2.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1635) DUF4570 PF15134.6 CDI84491.1 - 5.8 7.0 11.1 0.15 12.1 2.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Ribosomal_S2 PF00318.20 CDI84492.1 - 1.1e-30 106.6 1.0 1.4e-14 53.8 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 CDI84492.1 - 0.066 14.6 21.8 0.35 12.2 21.8 2.2 1 1 0 1 1 1 0 40S ribosomal protein SA C-terminus Sod_Fe_C PF02777.18 CDI84493.1 - 2.8e-35 120.5 0.1 2.8e-35 120.5 0.1 1.8 2 1 1 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDI84493.1 - 9.1e-34 115.8 1.0 2.1e-33 114.6 1.0 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain TAL_FSA PF00923.19 CDI84494.1 - 5.6e-95 318.0 0.9 6.7e-95 317.7 0.9 1.1 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase E1_4HB PF16191.5 CDI84495.1 - 0.014 15.5 0.1 0.026 14.7 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle Apt1 PF10351.9 CDI84497.1 - 0.045 12.6 0.0 0.045 12.6 0.0 2.3 3 0 0 3 3 3 0 Golgi-body localisation protein domain SAPIS-gp6 PF16722.5 CDI84497.1 - 0.052 14.0 2.7 0.052 14.0 2.7 2.5 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus RskA PF10099.9 CDI84497.1 - 0.087 13.1 7.6 0.095 13.0 1.3 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Cmyb_C PF09316.10 CDI84497.1 - 0.12 12.0 3.6 0.39 10.4 0.4 2.1 2 0 0 2 2 2 0 C-myb, C-terminal MAT1 PF06391.13 CDI84497.1 - 1.2 9.0 11.5 0.46 10.3 3.5 2.1 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 THOC2_N PF16134.5 CDI84497.1 - 1.4 7.5 11.3 1 7.9 1.6 2.1 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus Ribosomal_60s PF00428.19 CDI84497.1 - 2.1 9.0 9.6 1.8 9.2 1.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.13 CDI84498.1 - 0.85 9.5 23.4 0.069 13.1 14.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 CDI84498.1 - 4.1 7.3 7.6 0.57 10.1 3.4 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DnaJ_C PF01556.18 CDI84500.1 - 3.2e-34 118.1 0.1 4.9e-34 117.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDI84500.1 - 4.5e-25 87.5 1.5 8.2e-25 86.7 1.5 1.4 1 0 0 1 1 1 1 DnaJ domain TB PF00683.17 CDI84500.1 - 0.022 14.5 0.2 0.044 13.5 0.2 1.5 1 0 0 1 1 1 0 TB domain DnaJ_CXXCXGXG PF00684.19 CDI84500.1 - 0.16 12.3 3.9 0.32 11.4 3.9 1.4 1 0 0 1 1 1 0 DnaJ central domain Asp_protease_2 PF13650.6 CDI84501.1 - 5.3e-06 27.0 0.0 2.1e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.11 CDI84501.1 - 1e-05 25.4 0.0 1.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 CDI84501.1 - 0.0013 19.3 0.0 0.0035 17.9 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDI84501.1 - 0.08 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease DUF2237 PF09996.9 CDI84501.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) RT_RNaseH PF17917.1 CDI84502.1 - 2.6e-24 85.5 0.0 6.4e-24 84.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDI84502.1 - 9.3e-24 83.4 0.0 1.7e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Chromo PF00385.24 CDI84502.1 - 2.8e-15 56.0 0.0 5.4e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RVT_1 PF00078.27 CDI84502.1 - 3.5e-12 46.3 0.0 6.5e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CDI84502.1 - 2.6e-05 24.4 0.1 0.00014 22.0 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain PKS_DE PF18369.1 CDI84502.1 - 1.8 9.2 6.0 16 6.1 1.7 3.5 3 0 0 3 3 3 0 Polyketide synthase dimerisation element domain N2227 PF07942.12 CDI84503.1 - 3e-83 279.1 1.5 1.2e-82 277.1 0.0 2.1 2 0 0 2 2 2 1 N2227-like protein PI31_Prot_C PF08577.11 CDI84503.1 - 3.6e-08 34.5 6.9 3.6e-08 34.5 6.9 5.7 5 2 2 7 7 7 1 PI31 proteasome regulator DUF5427 PF10310.9 CDI84503.1 - 0.06 12.3 34.9 0.09 11.7 1.9 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Methyltransf_11 PF08241.12 CDI84503.1 - 0.14 12.9 0.5 0.8 10.4 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain GAGA_bind PF06217.12 CDI84503.1 - 0.89 9.8 30.8 1.2 9.4 23.8 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family V_ATPase_I PF01496.19 CDI84503.1 - 1.7 6.5 30.1 1.1 7.0 22.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SOBP PF15279.6 CDI84503.1 - 6.5 7.3 36.0 0.56 10.8 19.5 3.3 3 0 0 3 3 3 0 Sine oculis-binding protein TraG-D_C PF12696.7 CDI84504.1 - 1.9 8.5 5.6 0.52 10.3 1.8 2.0 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Connexin PF00029.19 CDI84505.1 - 0.0026 17.6 4.7 0.0026 17.6 4.7 8.2 2 1 1 4 4 4 1 Connexin CLN3 PF02487.17 CDI84505.1 - 0.0061 15.7 2.5 0.0061 15.7 2.5 7.8 2 1 2 4 4 4 1 CLN3 protein BAF1_ABF1 PF04684.13 CDI84506.1 - 0.035 13.2 13.5 0.073 12.1 13.5 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4228 PF14009.6 CDI84506.1 - 0.18 12.2 10.8 1.8 8.9 6.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Zip PF02535.22 CDI84506.1 - 0.19 10.9 3.7 0.28 10.4 3.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDI84506.1 - 0.4 9.4 13.7 0.049 12.4 9.7 1.5 2 0 0 2 2 2 0 Presenilin SDA1 PF05285.12 CDI84506.1 - 0.57 9.6 12.6 0.88 8.9 12.6 1.3 1 0 0 1 1 1 0 SDA1 Apt1 PF10351.9 CDI84506.1 - 3.1 6.5 22.3 1.5 7.6 16.9 2.0 2 0 0 2 2 2 0 Golgi-body localisation protein domain SLC12 PF03522.15 CDI84506.1 - 4.3 6.3 10.1 6.5 5.7 10.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Apc15p PF05841.11 CDI84506.1 - 4.7 8.0 17.4 1.8 9.4 13.7 2.3 2 0 0 2 2 2 0 Apc15p protein CDC45 PF02724.14 CDI84506.1 - 5.5 5.2 14.6 8.3 4.6 14.6 1.2 1 0 0 1 1 1 0 CDC45-like protein GCD14 PF08704.10 CDI84506.1 - 6.1 6.4 6.0 14 5.2 6.0 1.6 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Rep_fac-A_3 PF08661.11 CDI84507.1 - 8.8e-08 32.4 0.1 1.1e-07 32.1 0.1 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Ribosomal_L1 PF00687.21 CDI84508.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L1p/L10e family Paf1 PF03985.13 CDI84508.1 - 0.13 11.2 6.0 0.19 10.7 6.0 1.2 1 0 0 1 1 1 0 Paf1 Spore_coat_CotO PF14153.6 CDI84508.1 - 0.33 10.9 12.7 0.099 12.6 7.2 2.1 2 0 0 2 2 2 0 Spore coat protein CotO OAD_gamma PF04277.13 CDI84508.1 - 0.52 10.9 7.4 3.7 8.2 5.3 2.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF5308 PF17233.2 CDI84508.1 - 2.5 8.3 15.6 9 6.5 15.5 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5308) DUF4834 PF16118.5 CDI84508.1 - 2.6 9.1 7.1 4.2 8.4 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CDK2AP PF09806.9 CDI84508.1 - 3 7.9 14.1 1.5 8.9 6.7 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Mus7 PF09462.10 CDI84508.1 - 4.8 5.9 11.2 0.027 13.4 3.0 1.4 2 0 0 2 2 2 0 Mus7/MMS22 family TBK1_CCD1 PF18394.1 CDI84509.1 - 0.075 12.6 4.6 0.11 12.1 4.6 1.3 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 PRKG1_interact PF15898.5 CDI84509.1 - 0.82 10.6 6.2 2.8 8.9 6.2 2.0 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Chromo PF00385.24 CDI84510.1 - 2.2e-07 30.7 0.1 3.9e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PI3K_1B_p101 PF10486.9 CDI84510.1 - 0.18 9.6 8.1 0.28 8.9 8.1 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Collagen PF01391.18 CDI84511.1 - 0.0045 16.7 16.0 0.0045 16.7 16.0 4.4 4 0 0 4 4 4 1 Collagen triple helix repeat (20 copies) Synuclein PF01387.17 CDI84512.1 - 0.019 15.2 0.3 0.034 14.4 0.3 1.4 1 0 0 1 1 1 0 Synuclein Phostensin_N PF13916.6 CDI84512.1 - 0.064 13.6 3.4 0.055 13.8 2.1 1.7 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DUF2368 PF10166.9 CDI84512.1 - 0.61 9.7 4.4 0.9 9.1 4.4 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) RINGv PF12906.7 CDI84514.1 - 1.5e-12 47.4 4.5 1.5e-12 47.4 4.5 2.3 2 0 0 2 2 2 1 RING-variant domain FHA PF00498.26 CDI84514.1 - 3.7e-05 24.0 1.6 0.00099 19.4 0.8 2.5 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 CDI84514.1 - 0.0016 18.7 0.2 0.018 15.3 0.1 2.3 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain eIF-3_zeta PF05091.12 CDI84515.1 - 0.01 14.8 3.7 0.015 14.3 3.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) V_ATPase_I PF01496.19 CDI84515.1 - 0.58 8.0 3.4 0.8 7.5 3.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_60s PF00428.19 CDI84516.1 - 2.1e-17 63.5 8.3 2.1e-17 63.5 8.3 1.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein RL10P_insert PF17777.1 CDI84516.1 - 6.4e-05 22.9 0.0 0.00019 21.3 0.0 1.8 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 CDI84516.1 - 9.1e-05 22.5 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 DUF3138 PF11336.8 CDI84516.1 - 0.084 11.5 2.7 0.1 11.2 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) USP19_linker PF16602.5 CDI84516.1 - 0.21 12.1 2.9 1.7 9.2 0.0 2.1 2 0 0 2 2 2 0 Linker region of USP19 deubiquitinase WD40 PF00400.32 CDI84517.1 - 1.7e-28 98.3 16.0 9e-07 29.5 1.9 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 CDI84517.1 - 0.01 14.5 0.0 0.26 9.9 0.0 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CDI84517.1 - 0.035 14.4 0.2 5.7 7.3 0.0 3.6 2 2 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDI84517.1 - 0.073 12.4 0.0 1.6 8.0 0.0 2.3 1 1 1 2 2 2 0 WD40-like domain NAM-associated PF14303.6 CDI84517.1 - 0.31 11.7 0.0 0.31 11.7 0.0 2.5 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain SUIM_assoc PF16619.5 CDI84518.1 - 0.0074 16.3 0.0 0.0074 16.3 0.0 24.3 20 7 1 21 21 21 8 Unstructured region C-term to UIM in Ataxin3 zf_CCCH_4 PF18345.1 CDI84519.1 - 3.6e-11 42.7 19.4 1.2e-05 25.2 2.1 4.3 4 0 0 4 4 4 3 Zinc finger domain zf-CCCH PF00642.24 CDI84519.1 - 8.1e-10 38.4 17.0 2.3e-07 30.6 1.4 4.1 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDI84519.1 - 0.0063 16.3 14.4 0.0073 16.1 2.0 3.7 3 0 0 3 3 3 2 CCCH-type zinc finger Med15 PF09606.10 CDI84520.1 - 0.97 8.0 74.3 0.014 14.2 67.6 1.4 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Ribosomal_L6e PF01159.19 CDI84521.1 - 5.3e-36 123.5 1.4 7.5e-36 123.0 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Ycf54 PF10674.9 CDI84521.1 - 0.12 12.7 0.5 0.2 12.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Kelch_4 PF13418.6 CDI84522.1 - 4.6e-20 71.3 1.1 1.1e-07 31.8 0.0 4.5 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CDI84522.1 - 1.4e-13 50.8 1.2 0.003 17.8 0.0 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CDI84522.1 - 3e-11 43.0 0.2 0.044 13.8 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 CDI84522.1 - 3.4e-08 33.5 1.7 0.05 13.9 0.0 5.0 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 CDI84522.1 - 2.1e-05 24.0 0.6 0.34 10.5 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 CDI84522.1 - 0.0018 18.2 4.1 4 7.6 0.5 4.6 6 0 0 6 6 6 2 Kelch motif ECM11 PF15463.6 CDI84522.1 - 0.1 13.2 3.0 0.23 12.1 3.0 1.5 1 0 0 1 1 1 0 Extracellular mutant protein 11 UPF0242 PF06785.11 CDI84522.1 - 0.23 11.5 5.6 0.35 11.0 5.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sec2p PF06428.11 CDI84522.1 - 5.6 7.0 10.9 11 6.1 2.1 2.3 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Ribosomal_L28 PF00830.19 CDI84524.1 - 4e-16 58.9 2.5 3.1e-15 56.1 1.5 2.3 2 0 0 2 2 2 1 Ribosomal L28 family RRM_1 PF00076.22 CDI84525.1 - 1.1e-18 66.8 0.0 2.5e-05 24.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 CDI84533.1 - 0.022 14.8 2.0 0.022 14.8 2.0 3.1 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 CDI84533.1 - 0.15 11.6 3.2 0.26 10.9 3.2 1.3 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 CDI84533.1 - 0.49 9.3 3.1 0.76 8.6 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TFIIA PF03153.13 CDI84533.1 - 4.9 7.0 7.1 0.32 11.0 1.0 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Kinesin PF00225.23 CDI84534.1 - 1.6e-61 208.1 0.0 1.3e-41 142.6 0.0 2.7 3 0 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 CDI84534.1 - 4.3e-14 52.7 0.0 5.4e-11 42.6 0.0 2.8 3 0 0 3 3 3 2 Microtubule binding Prismane PF03063.20 CDI84535.1 - 0.15 10.7 2.2 0.18 10.5 2.2 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Med15 PF09606.10 CDI84535.1 - 0.2 10.3 18.4 0.24 10.1 18.4 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Spt20 PF12090.8 CDI84535.1 - 0.23 11.0 14.1 0.041 13.5 9.9 1.7 2 0 0 2 2 2 0 Spt20 family Hydin_ADK PF17213.3 CDI84535.1 - 2.6 8.3 7.5 3.2 8.0 7.5 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain zf-RING_2 PF13639.6 CDI84536.1 - 2.8e-08 34.0 2.1 8.5e-08 32.4 2.1 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDI84536.1 - 1.3e-07 31.8 1.2 4.1e-07 30.2 1.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDI84536.1 - 1.6e-05 24.7 2.5 2e-05 24.4 1.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDI84536.1 - 1.7e-05 24.5 3.6 5.2e-05 23.0 3.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDI84536.1 - 0.0002 21.0 1.9 0.0002 21.0 1.9 1.7 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 CDI84536.1 - 0.0012 18.8 1.4 0.004 17.2 1.4 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CDI84536.1 - 0.0034 17.0 1.4 0.0091 15.6 1.4 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 CDI84536.1 - 0.0036 17.2 1.1 0.0036 17.2 1.1 1.8 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDI84536.1 - 0.23 11.4 4.4 0.36 10.7 2.9 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDI84536.1 - 0.39 10.8 6.7 0.19 11.8 3.6 2.2 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDI84536.1 - 1.1 9.1 3.3 0.68 9.8 1.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) LPP20 PF02169.16 CDI84536.1 - 1.3 9.4 5.8 4.1 7.8 5.8 1.8 1 0 0 1 1 1 0 LPP20 lipoprotein FtsJ PF01728.19 CDI84537.1 - 3.9e-59 199.7 0.0 6.3e-59 199.0 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Vfa1 PF08432.10 CDI84537.1 - 0.37 11.1 10.0 0.058 13.7 3.0 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF1631 PF07793.11 CDI84537.1 - 1.8 6.9 15.7 1.1 7.6 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1631) Rib_recp_KP_reg PF05104.12 CDI84537.1 - 5.9 7.9 22.8 1 10.4 0.2 3.1 3 0 0 3 3 3 0 Ribosome receptor lysine/proline rich region SR-25 PF10500.9 CDI84537.1 - 8.3 5.9 32.5 1.8 8.1 2.7 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein SUIM_assoc PF16619.5 CDI84537.1 - 9.7 6.3 17.0 48 4.1 17.0 2.3 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Exo_endo_phos PF03372.23 CDI84538.1 - 0.0083 15.7 0.8 0.043 13.3 0.8 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RskA PF10099.9 CDI84538.1 - 0.44 10.8 80.8 0.048 14.0 12.9 4.9 1 1 2 3 3 3 0 Anti-sigma-K factor rskA RED_N PF07808.13 CDI84538.1 - 0.82 9.2 19.7 0.019 14.6 3.2 2.5 2 0 0 2 2 2 0 RED-like protein N-terminal region Rxt3 PF08642.10 CDI84538.1 - 4.4 8.1 5.6 31 5.4 1.8 2.6 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 UCH PF00443.29 CDI84539.1 - 1.3e-29 103.5 0.0 2e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CDI84539.1 - 7.5e-07 28.8 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UCH_1 PF13423.6 CDI84539.1 - 0.0022 17.7 0.2 0.12 12.0 0.0 2.8 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase TBK1_ULD PF18396.1 CDI84539.1 - 0.0077 16.1 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Herpes_capsid PF06112.11 CDI84539.1 - 5.8 6.9 22.6 1.2 9.2 4.9 3.2 3 0 0 3 3 3 0 Gammaherpesvirus capsid protein Secretin_N_2 PF07655.13 CDI84539.1 - 6.8 7.3 16.6 14 6.3 6.2 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Fasciclin PF02469.22 CDI84540.1 - 0.0036 17.5 0.0 0.0075 16.5 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain Trypsin_2 PF13365.6 CDI84541.1 - 9.7e-22 78.5 0.2 9.7e-22 78.5 0.2 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_3 PF17815.1 CDI84541.1 - 1.1e-19 70.7 0.0 4.1e-19 68.9 0.0 1.9 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 CDI84541.1 - 9e-15 55.1 0.3 1.5e-14 54.4 0.3 1.4 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 CDI84541.1 - 5.2e-06 26.7 0.1 4.1e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDI84541.1 - 4.8e-05 23.6 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDI84541.1 - 0.0012 18.6 0.0 0.0028 17.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Peptidase_S46 PF10459.9 CDI84541.1 - 0.048 12.3 0.0 0.074 11.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 Gram_pos_anchor PF00746.21 CDI84541.1 - 0.18 11.8 1.3 0.42 10.6 1.3 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif TAF4 PF05236.14 CDI84541.1 - 0.58 9.9 7.7 0.88 9.3 7.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Leu_Phe_trans PF03588.14 CDI84543.1 - 1.6e-09 37.5 0.1 3.9e-09 36.3 0.0 1.6 2 0 0 2 2 2 1 Leucyl/phenylalanyl-tRNA protein transferase zf-B_box PF00643.24 CDI84544.1 - 1.8e-11 44.0 12.9 1.6e-05 24.9 6.9 2.5 2 0 0 2 2 2 2 B-box zinc finger PARP PF00644.20 CDI84544.1 - 0.095 12.3 0.4 0.21 11.2 0.4 1.6 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain PseudoU_synth_1 PF01416.20 CDI84545.1 - 2.2 8.8 13.7 0.19 12.2 1.9 3.7 3 1 0 3 3 3 0 tRNA pseudouridine synthase RskA PF10099.9 CDI84546.1 - 0.0038 17.5 12.5 0.0047 17.2 12.5 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA SUIM_assoc PF16619.5 CDI84546.1 - 0.0059 16.6 0.5 0.0062 16.6 0.5 1.2 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Med3 PF11593.8 CDI84546.1 - 0.0094 15.2 9.8 0.011 15.0 9.8 1.0 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal AAA PF00004.29 CDI84547.1 - 2.2e-09 37.8 0.5 1.6e-08 35.0 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDI84547.1 - 9.1e-05 22.3 0.0 0.00024 20.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDI84547.1 - 0.00013 22.2 0.8 0.00013 22.2 0.8 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDI84547.1 - 0.003 18.1 0.0 0.016 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain eIF3_subunit PF08597.10 CDI84547.1 - 0.0036 17.2 1.4 0.0036 17.2 1.4 8.5 6 2 2 8 8 6 1 Translation initiation factor eIF3 subunit RskA PF10099.9 CDI84547.1 - 0.011 16.0 0.5 0.011 16.0 0.5 9.7 2 2 4 7 7 3 0 Anti-sigma-K factor rskA AAA_5 PF07728.14 CDI84547.1 - 0.015 15.3 0.0 0.045 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SPX PF03105.19 CDI84547.1 - 0.016 15.2 0.0 0.016 15.2 0.0 5.5 3 2 1 5 5 2 0 SPX domain ATPase_2 PF01637.18 CDI84547.1 - 0.084 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea CPT PF07931.12 CDI84547.1 - 0.13 12.1 4.5 0.44 10.4 0.1 3.1 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF4179 PF13786.6 CDI84547.1 - 4.8 7.7 0.0 4.8 7.7 0.0 8.8 8 2 0 8 8 5 0 Domain of unknown function (DUF4179) DUF4842 PF16130.5 CDI84547.1 - 6 7.0 10.7 5.8 7.0 3.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4842) PBP1_TM PF14812.6 CDI84548.1 - 0.012 16.0 12.4 0.015 15.7 12.4 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CPSF100_C PF13299.6 CDI84548.1 - 0.12 12.6 2.1 0.12 12.5 2.1 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RXT2_N PF08595.11 CDI84548.1 - 0.19 11.8 9.1 0.23 11.5 9.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2722 PF10846.8 CDI84548.1 - 0.19 10.6 3.1 0.18 10.7 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pox_Ag35 PF03286.14 CDI84548.1 - 0.25 11.1 10.2 0.28 10.9 10.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 CDI84548.1 - 0.33 9.2 15.4 0.35 9.1 15.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 CDI84548.1 - 0.43 9.7 25.9 0.45 9.6 25.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Vfa1 PF08432.10 CDI84548.1 - 0.87 9.9 5.7 0.97 9.7 5.7 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop14 PF04147.12 CDI84548.1 - 0.92 7.6 19.8 0.98 7.5 19.8 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 CDI84548.1 - 0.94 8.7 15.1 1 8.7 15.1 1.0 1 0 0 1 1 1 0 BUD22 DUF4637 PF15470.6 CDI84548.1 - 0.97 9.1 16.9 1.1 9.0 16.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CobT PF06213.12 CDI84548.1 - 0.99 8.7 19.9 1.1 8.6 19.9 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.12 CDI84548.1 - 1 7.8 16.7 1.1 7.6 16.7 1.0 1 0 0 1 1 1 0 Mpp10 protein PTPRCAP PF15713.5 CDI84548.1 - 1.1 9.6 18.9 1.2 9.5 18.9 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RPN2_C PF18004.1 CDI84548.1 - 1.3 8.9 7.0 1.5 8.7 7.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Zip PF02535.22 CDI84548.1 - 2.3 7.4 3.8 2.4 7.3 3.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Nop53 PF07767.11 CDI84548.1 - 2.4 7.5 14.9 2.6 7.3 14.9 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TFB6 PF17110.5 CDI84548.1 - 3.1 7.5 9.7 3.6 7.3 9.7 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SDA1 PF05285.12 CDI84548.1 - 3.4 7.0 20.5 3.7 6.9 20.5 1.0 1 0 0 1 1 1 0 SDA1 Paf1 PF03985.13 CDI84548.1 - 3.6 6.5 16.7 4 6.3 16.7 1.0 1 0 0 1 1 1 0 Paf1 Sigma70_ner PF04546.13 CDI84548.1 - 4 7.3 16.6 5 7.0 16.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region GCIP PF13324.6 CDI84548.1 - 4.3 6.8 11.6 4.6 6.8 11.6 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Cnd2 PF05786.14 CDI84548.1 - 4.4 5.9 10.6 5.1 5.6 10.6 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 SGT1 PF07093.11 CDI84548.1 - 5.5 5.3 10.2 6.1 5.2 10.2 1.0 1 0 0 1 1 1 0 SGT1 protein DNA_pol_phi PF04931.13 CDI84548.1 - 5.8 4.9 27.9 6.5 4.7 27.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi TLP-20 PF06088.11 CDI84548.1 - 5.9 6.8 6.5 6.9 6.5 6.5 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) NOA36 PF06524.12 CDI84548.1 - 7.8 5.7 22.9 9 5.5 22.9 1.1 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 CDI84548.1 - 8.3 6.1 18.9 9.4 5.9 18.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Rad60-SLD_2 PF13881.6 CDI84549.1 - 6.1e-05 23.1 0.0 7.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDI84549.1 - 0.00082 19.1 0.1 0.0042 16.8 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin family Na_trans_assoc PF06512.13 CDI84550.1 - 0.016 15.5 10.2 0.21 11.8 9.5 2.4 2 0 0 2 2 2 0 Sodium ion transport-associated Pkinase PF00069.25 CDI84550.1 - 0.017 14.5 1.2 0.028 13.8 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain Sporozoite_P67 PF05642.11 CDI84550.1 - 0.68 7.9 9.2 0.13 10.3 4.8 1.7 1 1 0 1 1 1 0 Sporozoite P67 surface antigen MMR1 PF08505.10 CDI84550.1 - 3.4 7.9 32.5 0.15 12.3 19.6 2.7 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein XRN_N PF03159.18 CDI84550.1 - 6.7 6.1 12.7 0.063 12.7 3.2 2.4 3 0 0 3 3 3 0 XRN 5'-3' exonuclease N-terminus Exo5 PF09810.9 CDI84551.1 - 1.5e-37 130.0 0.0 1.5e-37 130.0 0.0 4.6 2 1 1 3 3 3 1 Exonuclease V - a 5' deoxyribonuclease SOBP PF15279.6 CDI84551.1 - 0.00098 19.8 34.0 0.00098 19.8 34.0 3.7 3 1 1 4 4 4 2 Sine oculis-binding protein DIE2_ALG10 PF04922.12 CDI84553.1 - 0.48 9.6 1.0 1.8 7.7 1.0 2.0 1 0 0 1 1 1 0 DIE2/ALG10 family Spore_YhcN_YlaJ PF09580.10 CDI84553.1 - 0.74 9.9 6.8 4.7 7.3 0.0 3.4 4 0 0 4 4 4 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF2722 PF10846.8 CDI84554.1 - 0.00098 18.2 7.0 0.0011 18.0 7.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDI84554.1 - 0.0025 17.5 9.6 0.0025 17.5 9.6 1.1 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 CDI84554.1 - 0.024 14.7 11.3 0.025 14.6 11.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CDI84554.1 - 0.73 9.6 7.9 1.1 9.1 7.9 1.2 1 0 0 1 1 1 0 Septum formation initiator Activator_LAG-3 PF11498.8 CDI84554.1 - 0.99 8.3 21.6 1.3 7.9 21.6 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4834 PF16118.5 CDI84554.1 - 2 9.4 4.9 2.6 9.1 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SMC_N PF02463.19 CDI84555.1 - 1.2e-25 90.3 0.2 1.2e-25 90.3 0.2 3.5 2 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDI84555.1 - 2.2e-21 76.4 0.0 2.2e-21 76.4 0.0 4.1 5 0 0 5 5 5 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CDI84555.1 - 2e-05 24.5 0.0 4.2e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDI84555.1 - 4.1e-05 23.2 0.0 8.5e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF1289 PF06945.13 CDI84555.1 - 0.62 9.9 7.0 0.088 12.6 0.3 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) RRP36 PF06102.12 CDJ26762.1 - 0.009 16.0 15.6 0.009 16.0 15.6 3.3 3 1 0 4 4 4 1 rRNA biogenesis protein RRP36 HSP70 PF00012.20 CDJ26762.1 - 0.35 9.0 14.0 0.52 8.4 14.0 1.4 1 0 0 1 1 1 0 Hsp70 protein PRP38 PF03371.15 CDJ26763.1 - 6.3e-51 172.7 0.1 1.1e-50 171.9 0.1 1.4 1 0 0 1 1 1 1 PRP38 family PCB_OB PF17092.5 CDJ26763.1 - 0.0015 19.2 1.6 0.013 16.2 0.0 3.0 3 0 0 3 3 3 1 Penicillin-binding protein OB-like domain RMI2 PF16100.5 CDJ26763.1 - 0.044 13.6 0.0 0.044 13.6 0.0 2.3 2 0 0 2 2 2 0 RecQ-mediated genome instability protein 2 Tic110 PF16940.5 CDJ26763.1 - 2.7 6.4 9.8 4.3 5.7 9.8 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Pox_F12L PF03337.13 CDJ26764.1 - 0.075 11.2 1.7 0.068 11.3 0.9 1.3 1 1 0 1 1 1 0 Poxvirus F12L protein SR-25 PF10500.9 CDJ26764.1 - 0.17 11.5 15.3 0.043 13.4 11.9 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SLC12 PF03522.15 CDJ26765.1 - 0.0038 16.3 11.3 0.18 10.8 0.5 2.1 2 0 0 2 2 2 2 Solute carrier family 12 FAM60A PF15396.6 CDJ26765.1 - 0.5 10.3 10.6 2.2 8.2 3.4 2.3 2 0 0 2 2 2 0 Protein Family FAM60A DUF1676 PF07898.13 CDJ26765.1 - 0.58 10.2 6.2 0.34 10.9 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) eIF-3_zeta PF05091.12 CDJ26765.1 - 1.3 8.0 15.6 2.3 7.1 0.2 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) O-antigen_lig PF13425.6 CDJ26765.1 - 4.3 6.0 3.6 7.3 5.3 3.6 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RR_TM4-6 PF06459.12 CDJ26765.1 - 6.1 6.6 16.7 0.3 10.9 8.5 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4484 PF14831.6 CDJ26765.1 - 9.9 6.1 17.2 0.41 10.7 9.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) BSMAP PF12280.8 CDJ26766.1 - 0.014 15.6 0.0 0.017 15.3 0.0 1.1 1 0 0 1 1 1 0 Brain specific membrane anchored protein SARAF PF06682.12 CDJ26767.1 - 0.0049 16.6 2.5 0.0049 16.6 2.5 6.8 3 3 1 4 4 4 2 SOCE-associated regulatory factor of calcium homoeostasis DEAD PF00270.29 CDJ26768.1 - 5.3e-26 91.4 0.1 4.8e-25 88.3 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDJ26768.1 - 5.6e-14 52.4 0.1 4.2e-13 49.6 0.0 2.5 1 1 1 2 2 2 1 Helicase conserved C-terminal domain UTP25 PF06862.12 CDJ26768.1 - 0.0034 16.2 0.2 0.16 10.8 0.0 2.3 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 CDJ26768.1 - 0.015 15.7 0.0 0.052 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain RskA PF10099.9 CDJ26768.1 - 1 9.6 42.3 0.11 12.8 16.0 3.9 3 0 0 3 3 3 0 Anti-sigma-K factor rskA Peptidase_M24 PF00557.24 CDJ26769.1 - 3.3e-15 56.3 1.8 5.2e-11 42.6 0.1 2.3 1 1 0 2 2 2 2 Metallopeptidase family M24 RskA PF10099.9 CDJ26770.1 - 0.019 15.3 3.5 0.019 15.3 3.5 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA Spt20 PF12090.8 CDJ26771.1 - 0.0018 18.0 22.3 0.0018 17.9 22.3 1.0 1 0 0 1 1 1 1 Spt20 family DUF755 PF05501.11 CDJ26771.1 - 0.0081 16.4 17.2 0.0092 16.2 17.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF755) Med15 PF09606.10 CDJ26771.1 - 0.013 14.3 18.6 0.013 14.2 18.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RskA PF10099.9 CDJ26771.1 - 0.015 15.6 9.9 0.018 15.4 9.9 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF2722 PF10846.8 CDJ26771.1 - 0.015 14.2 18.4 0.017 14.1 18.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FlgH PF02107.16 CDJ26771.1 - 0.023 14.3 6.7 0.027 14.1 6.7 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein EphA2_TM PF14575.6 CDJ26771.1 - 0.31 12.0 6.2 0.37 11.7 6.2 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain GTA_holin_3TM PF11351.8 CDJ26771.1 - 0.39 11.3 8.7 0.45 11.1 8.7 1.1 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release OPT PF03169.15 CDJ26771.1 - 0.53 8.8 1.6 0.52 8.9 1.6 1.0 1 0 0 1 1 1 0 OPT oligopeptide transporter protein Connexin PF00029.19 CDJ26771.1 - 0.56 9.9 3.5 0.63 9.8 3.5 1.0 1 0 0 1 1 1 0 Connexin Activator_LAG-3 PF11498.8 CDJ26771.1 - 0.87 8.5 22.2 0.93 8.4 22.2 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Cadherin_C_2 PF16492.5 CDJ26771.1 - 0.9 10.3 4.1 1.2 10.0 4.1 1.3 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal FxsA PF04186.13 CDJ26771.1 - 1 9.5 2.4 1.3 9.2 2.4 1.1 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein Neur_chan_memb PF02932.16 CDJ26771.1 - 1.2 9.1 5.3 1.3 9.0 5.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Lin-8 PF03353.15 CDJ26771.1 - 1.2 8.6 14.3 1.4 8.4 14.3 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF775 PF05603.12 CDJ26771.1 - 1.5 8.3 10.5 1.7 8.1 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF4064 PF13273.6 CDJ26771.1 - 2 8.7 3.5 2.6 8.4 3.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) Conotoxin PF02950.17 CDJ26771.1 - 2.3 9.3 6.4 5.9 8.0 6.4 1.7 1 1 0 1 1 1 0 Conotoxin TFIIA PF03153.13 CDJ26771.1 - 2.8 7.8 21.7 3 7.8 21.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MPM1 PF17234.2 CDJ26771.1 - 2.8 8.1 11.8 3.2 8.0 11.8 1.0 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 CcmD PF04995.14 CDJ26771.1 - 3 8.0 6.9 5.5 7.2 6.9 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) CLN3 PF02487.17 CDJ26771.1 - 4.8 6.1 6.5 4.9 6.1 6.5 1.0 1 0 0 1 1 1 0 CLN3 protein Roughex PF06020.11 CDJ26771.1 - 5.8 5.9 11.7 6.1 5.8 11.7 1.0 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 CDJ26771.1 - 8.4 5.0 11.9 9.2 4.9 11.9 1.1 1 0 0 1 1 1 0 Presenilin T4BSS_DotI_IcmL PF11393.8 CDJ26773.1 - 0.098 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component HA2 PF04408.23 CDJ26775.1 - 3.5e-19 69.1 0.0 3.5e-19 69.1 0.0 3.6 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDJ26775.1 - 4.9e-15 55.7 0.0 9.6e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDJ26775.1 - 9.9e-13 48.4 0.0 2.2e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDJ26775.1 - 0.00013 22.3 3.9 0.00022 21.5 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_19 PF13245.6 CDJ26775.1 - 0.002 18.5 1.0 0.0049 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDJ26775.1 - 0.0025 16.9 2.4 0.007 15.5 2.4 1.7 1 1 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.29 CDJ26775.1 - 0.0028 17.4 1.1 0.1 12.3 1.1 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase cobW PF02492.19 CDJ26775.1 - 0.037 13.6 0.1 0.9 9.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CDJ26775.1 - 0.088 13.2 0.2 0.088 13.2 0.2 4.5 1 1 1 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CDJ26775.1 - 3.8 7.9 0.0 3.8 7.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain Serpin PF00079.20 CDJ26776.1 - 1e-70 239.0 0.0 1.2e-70 238.7 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) LAG1-DNAbind PF09271.11 CDJ26776.1 - 0.2 12.3 0.0 0.38 11.4 0.0 1.5 1 0 0 1 1 1 0 LAG1, DNA binding zf-C2H2_4 PF13894.6 CDJ26777.1 - 0.02 15.7 0.5 0.02 15.7 0.5 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CDJ26777.1 - 0.042 14.3 0.3 0.2 12.2 0.3 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type Cpn60_TCP1 PF00118.24 CDJ26779.1 - 3.8e-40 138.0 0.0 4.2e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family eIF-6 PF01912.18 CDJ26779.1 - 0.044 13.2 0.0 0.056 12.8 0.0 1.1 1 0 0 1 1 1 0 eIF-6 family Methyltransf_23 PF13489.6 CDJ26780.1 - 0.057 13.3 0.0 0.057 13.3 0.0 6.2 8 1 0 8 8 8 0 Methyltransferase domain VCBS PF13517.6 CDJ26781.1 - 5.9e-18 65.2 6.7 7.5e-07 29.6 0.6 6.9 6 1 1 7 7 7 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDJ26781.1 - 3.5e-09 36.6 17.2 1.2e-05 25.3 0.8 6.0 6 0 0 6 6 6 3 FG-GAP repeat TCP PF03634.13 CDJ26781.1 - 0.014 16.0 5.0 0.014 16.0 5.0 6.4 7 0 0 7 7 7 0 TCP family transcription factor Oxidored_q3 PF00499.20 CDJ26781.1 - 0.053 13.2 0.1 6.2 6.5 0.0 3.2 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 TMEM51 PF15345.6 CDJ26781.1 - 0.1 12.4 0.0 0.1 12.4 0.0 7.4 7 2 1 8 8 8 0 Transmembrane protein 51 DUF1467 PF07330.12 CDJ26781.1 - 0.32 11.0 1.1 4.5 7.3 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) DUF5523 PF17661.1 CDJ26781.1 - 5.6 6.6 18.2 0.11 12.2 4.2 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5523) DUF4471 PF14740.6 CDJ26781.1 - 7.4 5.7 10.0 11 5.2 2.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) Tmemb_9 PF05434.11 CDJ26781.1 - 9.6 6.1 0.0 9.6 6.1 0.0 4.6 6 0 0 6 6 6 0 TMEM9 Hamartin PF04388.12 CDJ26782.1 - 0.36 9.4 31.7 0.59 8.7 31.7 1.2 1 0 0 1 1 1 0 Hamartin protein NARP1 PF12569.8 CDJ26782.1 - 0.44 9.4 22.8 0.65 8.8 21.4 2.0 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Lin-8 PF03353.15 CDJ26782.1 - 5.7 6.4 27.2 2.8 7.4 19.4 2.8 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist RR_TM4-6 PF06459.12 CDJ26782.1 - 5.8 6.6 37.6 0.021 14.7 24.4 2.9 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 SWI-SNF_Ssr4 PF08549.10 CDJ26785.1 - 0.39 9.3 16.3 0.49 9.0 16.3 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RskA PF10099.9 CDJ26786.1 - 8.3e-08 32.7 4.1 8.3e-08 32.7 4.1 4.1 2 2 0 2 2 2 1 Anti-sigma-K factor rskA Presenilin PF01080.17 CDJ26786.1 - 0.0058 15.4 29.6 0.01 14.6 10.6 2.3 2 0 0 2 2 2 2 Presenilin DUF4746 PF15928.5 CDJ26786.1 - 0.065 12.7 20.9 0.29 10.5 8.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Gti1_Pac2 PF09729.9 CDJ26786.1 - 5.3 7.1 29.8 3.9 7.5 12.9 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Peptidase_S64 PF08192.11 CDJ26786.1 - 7 5.0 27.3 1.1 7.7 9.2 2.0 2 0 0 2 2 2 0 Peptidase family S64 FAM199X PF15814.5 CDJ26787.1 - 0.00011 21.4 12.6 0.00011 21.4 12.6 3.3 4 0 0 4 4 4 1 Protein family FAM199X DUF4207 PF13904.6 CDJ26787.1 - 0.0069 16.1 6.1 0.0069 16.1 6.1 3.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4207) DUF3464 PF11947.8 CDJ26787.1 - 0.011 15.5 3.3 0.011 15.5 3.3 4.4 4 0 0 4 4 4 0 Photosynthesis affected mutant 68 DUF2722 PF10846.8 CDJ26787.1 - 0.21 10.5 86.0 0.013 14.5 4.7 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2722) PRP1_N PF06424.12 CDJ26787.1 - 4.3 7.7 42.4 0.3 11.5 0.5 4.2 4 0 0 4 4 4 0 PRP1 splicing factor, N-terminal DUF1467 PF07330.12 CDJ26787.1 - 6.1 6.9 6.0 43 4.1 1.2 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) Ribosomal_60s PF00428.19 CDJ26788.1 - 0.001 19.6 20.7 0.001 19.6 4.9 2.5 2 0 0 2 2 2 2 60s Acidic ribosomal protein MeMO_Hyd_G PF02964.16 CDJ26788.1 - 0.041 13.9 0.4 0.076 13.0 0.4 1.4 1 0 0 1 1 1 0 Methane monooxygenase, hydrolase gamma chain TFIIA PF03153.13 CDJ26788.1 - 0.43 10.5 10.0 1.6 8.6 2.7 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Dynein_C PF18199.1 CDJ26789.1 - 6e-75 252.3 0.0 7.2e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDJ26789.1 - 2.7e-41 141.1 0.0 5.5e-41 140.1 0.0 1.5 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain V-ATPase_H_C PF11698.8 CDJ26790.1 - 1.2e-37 128.6 0.7 1.2e-37 128.6 0.7 2.2 2 1 0 2 2 2 1 V-ATPase subunit H UvrD_C PF13361.6 CDJ26790.1 - 0.0055 16.1 0.2 0.0058 16.1 0.2 1.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Cyt-b5 PF00173.28 CDJ26790.1 - 0.069 13.3 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain PNKP_ligase PF16542.5 CDJ26790.1 - 0.21 11.0 7.5 0.46 9.9 7.5 1.5 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain DDHD PF02862.17 CDJ26790.1 - 1.6 8.8 9.1 2.9 8.0 9.1 1.4 1 0 0 1 1 1 0 DDHD domain V_ATPase_I PF01496.19 CDJ26790.1 - 2.6 5.9 19.2 3.7 5.4 19.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF572 PF04502.13 CDJ26790.1 - 7.7 6.0 18.4 14 5.1 18.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lin-8 PF03353.15 CDJ26790.1 - 9.8 5.6 25.3 24 4.4 25.3 1.6 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.13 CDJ26791.1 - 0.0026 17.8 8.7 0.0029 17.7 8.7 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Glyco_hydro_108 PF05838.12 CDJ26791.1 - 0.0074 16.7 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase 108 CDC13_N PF16853.5 CDJ26791.1 - 0.021 14.3 1.0 0.029 13.9 1.0 1.2 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus SUIM_assoc PF16619.5 CDJ26791.1 - 0.082 13.0 10.9 0.18 11.9 10.9 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4407 PF14362.6 CDJ26791.1 - 0.15 11.4 3.7 0.22 10.8 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HD_4 PF13328.6 CDJ26791.1 - 0.28 10.9 5.5 0.48 10.1 4.5 1.9 1 1 0 1 1 1 0 HD domain OmpH PF03938.14 CDJ26791.1 - 0.95 9.8 20.0 2 8.7 15.2 2.5 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) PP2C PF00481.21 CDJ26793.1 - 9.6e-30 104.1 11.5 5.7e-29 101.5 4.9 5.4 5 2 1 7 7 7 2 Protein phosphatase 2C RskA PF10099.9 CDJ26793.1 - 7 6.9 0.0 1.8 8.8 19.5 13.4 6 5 5 11 11 11 0 Anti-sigma-K factor rskA HTH_Tnp_1 PF01527.20 CDJ26794.1 - 0.00053 20.2 0.1 0.00053 20.2 0.1 2.5 2 1 0 2 2 2 1 Transposase CytochromB561_N PF09786.9 CDJ26794.1 - 0.15 11.0 27.0 0.2 10.6 27.0 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal KleE PF17394.2 CDJ26794.1 - 4.9 7.4 6.6 1.7 8.9 0.2 3.1 2 1 0 2 2 2 0 Uncharacterized KleE stable inheritance protein Bromodomain PF00439.25 CDJ26795.1 - 1.3e-12 47.6 0.0 2.5e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Bromodomain Spt20 PF12090.8 CDJ26795.1 - 0.0022 17.7 6.6 0.0022 17.7 6.6 12.6 9 2 0 10 10 10 3 Spt20 family RskA PF10099.9 CDJ26795.1 - 0.033 14.5 0.3 0.033 14.5 0.3 19.0 7 4 6 13 13 13 0 Anti-sigma-K factor rskA DUF348 PF03990.14 CDJ26797.1 - 0.15 11.9 0.7 8.6 6.2 0.0 3.6 4 0 0 4 4 4 0 G5-linked-Ubiquitin-like domain MscS_TM PF12794.7 CDJ26797.1 - 1.4 7.7 4.2 3.5 6.4 4.2 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF702 PF05142.12 CDJ26798.1 - 0.014 15.9 9.4 0.014 15.9 9.4 8.0 4 1 3 8 8 8 0 Domain of unknown function (DUF702) BPL_LplA_LipB PF03099.19 CDJ26799.1 - 2.9e-08 33.7 0.2 6.2e-08 32.6 0.2 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family SUIM_assoc PF16619.5 CDJ26799.1 - 4e-06 26.8 34.1 0.00041 20.3 0.0 5.3 5 1 0 5 5 5 2 Unstructured region C-term to UIM in Ataxin3 BPL_C PF02237.17 CDJ26799.1 - 0.017 15.0 0.1 0.046 13.6 0.1 1.7 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain RskA PF10099.9 CDJ26799.1 - 0.09 13.1 0.0 0.09 13.1 0.0 5.7 1 1 3 5 5 5 0 Anti-sigma-K factor rskA Ribosomal_60s PF00428.19 CDJ26799.1 - 0.16 12.6 0.2 0.16 12.6 0.2 5.6 3 1 1 4 4 4 0 60s Acidic ribosomal protein WTX PF09422.10 CDJ26799.1 - 0.3 10.1 6.4 0.92 8.5 6.4 1.8 1 1 0 1 1 1 0 WTX protein DUF2722 PF10846.8 CDJ26799.1 - 0.3 10.0 20.3 0.36 9.7 1.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 CDJ26799.1 - 1.1 8.8 32.2 0.028 14.0 0.9 3.7 4 0 0 4 4 4 0 Spt20 family Caldesmon PF02029.15 CDJ26800.1 - 0.0021 16.9 33.5 0.0035 16.2 33.5 1.3 1 0 0 1 1 1 1 Caldesmon CNDH2_M PF16869.5 CDJ26801.1 - 0.042 14.5 1.3 0.13 13.0 0.3 2.3 2 0 0 2 2 2 0 PF16858 Ist1 PF03398.14 CDJ26802.1 - 2.2e-26 92.7 0.1 8.8e-26 90.8 0.1 1.9 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway SUIM_assoc PF16619.5 CDJ26802.1 - 0.00073 19.5 2.7 0.0014 18.7 2.7 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 CDJ26802.1 - 0.072 13.1 10.8 0.088 12.8 10.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 CDJ26802.1 - 0.56 9.8 13.3 0.87 9.1 13.3 1.3 1 0 0 1 1 1 0 Spt20 family VPS13 PF16908.5 CDJ26803.1 - 4e-14 53.0 9.0 1e-13 51.7 0.2 3.3 3 0 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 CDJ26803.1 - 7.9e-06 25.4 0.0 2.8e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 CDJ26803.1 - 0.00011 22.5 3.1 0.00022 21.5 0.0 3.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 CDJ26803.1 - 0.1 12.3 4.2 20 4.9 0.1 3.5 2 1 1 3 3 3 0 Vacuolar-sorting-associated 13 protein C-terminal Abhydrolase_3 PF07859.13 CDJ26804.1 - 0.00052 19.9 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CDJ26804.1 - 0.0086 15.0 0.0 0.0095 14.9 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Nop52 PF05997.12 CDJ26805.1 - 4.6e-41 141.0 4.5 4.6e-41 141.0 4.5 2.3 2 0 0 2 2 2 1 Nucleolar protein,Nop52 Spt20 PF12090.8 CDJ26806.1 - 0.07 12.7 2.8 0.14 11.8 2.8 1.5 1 0 0 1 1 1 0 Spt20 family Period_C PF12114.8 CDJ26806.1 - 0.16 11.5 4.5 0.31 10.6 4.5 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region RRM_1 PF00076.22 CDJ26807.1 - 0.0013 18.6 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nucleic_acid_bd PF13820.6 CDJ26807.1 - 0.049 13.5 0.1 0.054 13.3 0.1 1.2 1 0 0 1 1 1 0 Putative nucleic acid-binding region Plasmodium_Vir PF05795.11 CDJ26808.1 - 0.13 11.6 3.8 0.16 11.3 3.8 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF3807 PF12720.7 CDJ26808.1 - 0.56 10.5 7.3 0.92 9.8 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4551 PF15087.6 CDJ26808.1 - 2.7 6.7 7.5 3.4 6.4 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Presenilin PF01080.17 CDJ26808.1 - 4.6 5.9 5.7 6.4 5.4 5.7 1.3 1 0 0 1 1 1 0 Presenilin Rrn6 PF10214.9 CDJ26808.1 - 5.9 5.2 13.0 7.9 4.8 13.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor GREB1 PF15782.5 CDJ26808.1 - 6.3 3.8 8.9 7.4 3.6 8.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CDJ26809.1 - 0.00065 19.8 51.0 0.00065 19.8 51.0 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CDJ26809.1 - 0.019 12.1 23.1 0.025 11.8 23.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF-3_zeta PF05091.12 CDJ26809.1 - 0.027 13.5 15.8 0.042 12.8 15.8 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 CDJ26809.1 - 0.066 11.5 29.0 0.084 11.1 29.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.11 CDJ26809.1 - 0.23 10.9 14.7 0.47 9.8 14.7 1.5 1 0 0 1 1 1 0 Plasmodium vivax Vir protein VIR_N PF15912.5 CDJ26809.1 - 0.43 10.1 12.8 0.62 9.6 12.8 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal BUD22 PF09073.10 CDJ26809.1 - 0.57 9.5 36.8 0.025 13.9 31.3 1.4 2 0 0 2 2 2 0 BUD22 CDC45 PF02724.14 CDJ26809.1 - 0.65 8.2 27.8 0.97 7.6 27.8 1.1 1 0 0 1 1 1 0 CDC45-like protein NARP1 PF12569.8 CDJ26809.1 - 0.77 8.6 16.9 1.2 8.0 16.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SID-1_RNA_chan PF13965.6 CDJ26809.1 - 1.4 7.2 4.4 2.3 6.5 4.4 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Nop14 PF04147.12 CDJ26809.1 - 2.3 6.3 27.8 3.1 5.9 27.8 1.1 1 0 0 1 1 1 0 Nop14-like family Lin-8 PF03353.15 CDJ26809.1 - 2.7 7.5 35.1 4.5 6.7 35.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LETM1 PF07766.13 CDJ26809.1 - 3.1 7.1 12.6 4.9 6.4 12.6 1.2 1 0 0 1 1 1 0 LETM1-like protein SLC12 PF03522.15 CDJ26809.1 - 4.1 6.3 23.5 5.8 5.8 23.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Smg8_Smg9 PF10220.9 CDJ26809.1 - 4.8 5.3 19.6 6.8 4.9 19.6 1.3 1 0 0 1 1 1 0 Smg8_Smg9 Bud13 PF09736.9 CDJ26809.1 - 5.8 7.3 26.9 14 6.0 26.9 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex V_ATPase_I PF01496.19 CDJ26809.1 - 6.3 4.6 21.3 9 4.1 21.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SNARE_assoc PF09335.11 CDJ26810.1 - 6.1e-07 30.0 2.0 6.1e-07 30.0 2.0 4.0 3 1 1 4 4 4 1 SNARE associated Golgi protein RskA PF10099.9 CDJ26810.1 - 9.4e-05 22.8 15.5 0.047 14.0 0.0 4.4 3 1 0 4 4 4 1 Anti-sigma-K factor rskA PRCC PF10253.9 CDJ26810.1 - 0.00023 22.0 2.8 0.021 15.6 0.5 2.2 2 0 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting TFIIA PF03153.13 CDJ26810.1 - 0.0012 18.9 20.4 0.021 14.9 2.9 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF1980 PF09323.10 CDJ26810.1 - 0.017 15.0 2.7 2.3 8.1 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1980) DUF2722 PF10846.8 CDJ26810.1 - 0.058 12.3 21.7 0.088 11.7 11.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF4834 PF16118.5 CDJ26810.1 - 0.23 12.5 7.7 1.6 9.8 2.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 CDJ26810.1 - 0.32 11.4 4.8 3.5 8.0 1.7 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Transgly_assoc PF04226.13 CDJ26810.1 - 0.39 11.0 6.0 1.2 9.5 6.0 1.9 1 0 0 1 1 1 0 Transglycosylase associated protein DUF4175 PF13779.6 CDJ26810.1 - 0.69 7.7 22.0 1.1 7.1 8.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Suf PF05843.14 CDJ26810.1 - 0.74 9.7 8.9 0.32 10.9 2.6 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Senescence_reg PF04520.13 CDJ26810.1 - 2.2 9.1 8.8 5.2 7.9 6.4 2.3 2 0 0 2 2 2 0 Senescence regulator Pex14_N PF04695.13 CDJ26810.1 - 4.1 8.0 20.9 17 6.0 0.5 3.2 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.13 CDJ26810.1 - 4.6 7.0 9.6 4.7 6.9 3.2 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain IMUP PF15761.5 CDJ26810.1 - 7.4 7.3 29.6 4.2 8.1 10.3 3.5 3 0 0 3 3 3 0 Immortalisation up-regulated protein SpoIIE PF07228.12 CDJ26811.1 - 2.8 7.8 9.5 1.4 8.8 5.2 2.5 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) DFRP_C PF16543.5 CDJ26812.1 - 1e-15 58.0 8.4 1e-15 58.0 8.4 3.2 1 1 2 3 3 3 1 DRG Family Regulatory Proteins, Tma46 SR-25 PF10500.9 CDJ26812.1 - 0.0025 17.5 27.7 0.0025 17.5 27.7 3.4 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein SARAF PF06682.12 CDJ26812.1 - 0.048 13.3 14.0 0.12 12.0 14.1 1.7 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Utp14 PF04615.13 CDJ26812.1 - 0.073 11.6 24.6 0.091 11.3 24.6 1.0 1 0 0 1 1 1 0 Utp14 protein BUD22 PF09073.10 CDJ26812.1 - 0.17 11.2 37.2 2.4 7.4 37.0 1.9 1 1 0 1 1 1 0 BUD22 Secretin_N_2 PF07655.13 CDJ26812.1 - 0.17 12.4 19.1 0.44 11.1 19.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain GREB1 PF15782.5 CDJ26812.1 - 1.5 5.8 18.9 1.7 5.6 18.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PI3K_1B_p101 PF10486.9 CDJ26812.1 - 1.7 6.3 19.7 0.16 9.7 14.3 1.8 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Peptidase_C14 PF00656.22 CDJ26812.1 - 2.7 7.9 8.4 0.9 9.4 0.3 2.2 2 0 0 2 2 2 0 Caspase domain FAM104 PF15434.6 CDJ26812.1 - 4.7 7.8 20.2 14 6.3 20.2 1.8 1 0 0 1 1 1 0 Family 104 Herpes_pp85 PF04637.12 CDJ26812.1 - 8 4.8 20.6 14 4.0 20.6 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RR_TM4-6 PF06459.12 CDJ26813.1 - 1.8 8.3 8.1 2.7 7.8 8.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Suf PF05843.14 CDJ26813.1 - 3.1 7.7 6.4 4.7 7.1 6.4 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM60A PF15396.6 CDJ26813.1 - 5.9 6.8 6.7 10 6.1 6.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Pkinase PF00069.25 CDJ26814.1 - 1.4e-38 132.8 0.0 1.5e-38 132.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDJ26814.1 - 1.6e-16 60.4 0.0 1.8e-16 60.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDJ26814.1 - 1.3e-06 27.9 0.0 2.1e-06 27.3 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDJ26814.1 - 0.00015 20.7 0.0 0.00017 20.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDJ26814.1 - 0.00052 19.4 0.0 0.00069 19.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDJ26814.1 - 0.0013 18.8 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family XAP5 PF04921.14 CDJ26816.1 - 1.6 8.5 8.1 1.8 8.4 8.1 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator GOLD_2 PF13897.6 CDJ26816.1 - 1.8 9.1 4.0 2.3 8.7 4.0 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking PP_M1 PF03012.14 CDJ26816.1 - 2.1 7.8 7.7 2.2 7.7 7.7 1.0 1 0 0 1 1 1 0 Phosphoprotein CDC45 PF02724.14 CDJ26816.1 - 3.7 5.7 9.4 4.1 5.6 9.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDJ26816.1 - 9.2 4.9 6.2 10 4.8 6.2 1.0 1 0 0 1 1 1 0 Presenilin RibD_C PF01872.17 CDJ26817.1 - 0.039 13.8 0.2 0.039 13.8 0.2 2.6 3 0 0 3 3 3 0 RibD C-terminal domain CD20 PF04103.15 CDJ26819.1 - 0.0068 16.5 0.3 0.0099 16.0 0.3 1.3 1 0 0 1 1 1 1 CD20-like family BAF1_ABF1 PF04684.13 CDJ26819.1 - 0.48 9.4 7.6 0.64 9.0 7.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4366 PF14283.6 CDJ26819.1 - 7.9 6.5 13.6 3 7.9 3.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) PI-PLC-X PF00388.19 CDJ26821.1 - 3.4e-09 36.4 0.0 1.3e-08 34.5 0.0 1.7 1 1 1 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain Med3 PF11593.8 CDJ26821.1 - 4 6.5 11.7 5.6 6.0 11.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Med15 PF09606.10 CDJ26823.1 - 0.0027 16.5 75.3 0.0027 16.5 75.3 2.4 2 1 0 2 2 2 1 ARC105 or Med15 subunit of Mediator complex non-fungal Coilin_N PF15862.5 CDJ26823.1 - 0.0034 17.2 1.4 0.0034 17.2 1.4 4.2 2 1 1 3 3 3 1 Coilin N-terminus AMP-binding PF00501.28 CDJ26824.1 - 1.5e-37 129.2 0.0 2.5e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDJ26824.1 - 2.6e-05 25.1 0.1 4.8e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Creatinase_N PF01321.18 CDJ26824.1 - 0.0082 16.8 0.1 0.013 16.1 0.1 1.3 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain NYN_YacP PF05991.11 CDJ26824.1 - 0.15 12.0 0.1 0.23 11.4 0.1 1.2 1 0 0 1 1 1 0 YacP-like NYN domain tRNA_bind_2 PF13725.6 CDJ26825.1 - 7.1e-31 107.7 0.0 8e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 Possible tRNA binding domain Herpes_LP PF03363.13 CDJ26825.1 - 0.023 14.5 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus leader protein PIP5K PF01504.18 CDJ26826.1 - 2.9e-09 36.5 0.4 3.6e-09 36.2 0.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF1416 PF07210.12 CDJ26826.1 - 0.16 11.8 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1416) Cpn60_TCP1 PF00118.24 CDJ26827.1 - 1.2e-37 129.7 4.1 4.3e-37 127.9 4.1 1.7 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family GP3_package PF16677.5 CDJ26827.1 - 0.015 15.4 0.9 1.1 9.4 0.1 2.4 2 0 0 2 2 2 0 DNA-packaging protein gp3 DNA_primase_lrg PF04104.14 CDJ26827.1 - 0.046 13.1 2.8 0.6 9.5 0.2 2.1 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit Nbl1_Borealin_N PF10444.9 CDJ26827.1 - 0.12 12.1 2.4 0.16 11.7 0.6 2.1 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal DUF885 PF05960.11 CDJ26827.1 - 0.2 11.3 3.4 0.47 10.0 3.5 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Matrilin_ccoil PF10393.9 CDJ26827.1 - 1.1 9.2 3.2 0.73 9.7 0.6 2.1 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin V-ATPase_H_N PF03224.14 CDJ26828.1 - 0.0038 16.5 0.0 0.0042 16.4 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit H Glyco_transf_20 PF00982.21 CDJ26829.1 - 2.2e-14 53.0 0.0 2.3e-14 52.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 AAA_18 PF13238.6 CDJ26832.1 - 3.8e-26 92.2 0.0 6e-26 91.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CDJ26832.1 - 6.4e-07 29.9 0.2 4.4e-06 27.1 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 CDJ26832.1 - 6.4e-06 26.4 0.2 6.2e-05 23.2 0.2 2.5 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CDJ26832.1 - 3.1e-05 24.0 0.0 7.6e-05 22.7 0.0 1.6 2 0 0 2 2 1 1 NTPase AAA_28 PF13521.6 CDJ26832.1 - 4.3e-05 23.8 0.1 0.00013 22.2 0.0 1.7 1 1 0 2 2 2 1 AAA domain AAA PF00004.29 CDJ26832.1 - 9.2e-05 22.9 0.1 0.0002 21.8 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 CDJ26832.1 - 0.00018 21.1 0.1 0.00048 19.7 0.0 1.8 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 CDJ26832.1 - 0.00024 21.5 0.2 0.00057 20.3 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDJ26832.1 - 0.00025 21.3 0.1 0.00041 20.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 CDJ26832.1 - 0.00089 19.4 0.1 0.028 14.5 0.0 2.4 2 1 1 3 3 2 1 Adenylate kinase SKI PF01202.22 CDJ26832.1 - 0.0009 19.4 0.3 0.0097 16.0 0.3 2.4 1 1 0 1 1 1 1 Shikimate kinase AAA_14 PF13173.6 CDJ26832.1 - 0.0013 18.7 0.1 0.0094 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDJ26832.1 - 0.0015 18.9 0.0 0.0026 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.6 CDJ26832.1 - 0.0022 18.3 0.0 0.004 17.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 CDJ26832.1 - 0.0032 17.4 0.2 0.0094 15.9 0.0 1.8 2 1 0 2 2 2 1 NACHT domain Sigma54_activat PF00158.26 CDJ26832.1 - 0.0032 17.2 0.3 0.51 10.0 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 CDJ26832.1 - 0.0035 17.1 0.0 0.0062 16.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 CDJ26832.1 - 0.0042 16.5 0.1 0.0088 15.4 0.0 1.5 2 0 0 2 2 2 1 KaiC AAA_24 PF13479.6 CDJ26832.1 - 0.005 16.6 0.0 0.011 15.4 0.0 1.7 2 1 1 3 3 2 1 AAA domain T2SSE PF00437.20 CDJ26832.1 - 0.0055 15.8 0.1 0.019 14.0 0.0 1.9 2 1 0 2 2 2 1 Type II/IV secretion system protein ATPase_2 PF01637.18 CDJ26832.1 - 0.0068 16.3 0.0 0.011 15.6 0.0 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea TsaE PF02367.17 CDJ26832.1 - 0.01 15.8 0.0 0.022 14.8 0.0 1.6 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 CDJ26832.1 - 0.012 15.4 0.1 0.034 13.9 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 CDJ26832.1 - 0.015 15.3 0.0 0.038 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) dNK PF01712.19 CDJ26832.1 - 0.015 15.2 0.0 0.18 11.6 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase Viral_helicase1 PF01443.18 CDJ26832.1 - 0.015 15.0 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 CDJ26832.1 - 0.016 14.2 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 CDJ26832.1 - 0.017 14.4 0.0 0.025 13.8 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain Rad17 PF03215.15 CDJ26832.1 - 0.018 15.0 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 CDJ26832.1 - 0.026 14.0 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDJ26832.1 - 0.033 13.9 0.0 0.087 12.5 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Hydin_ADK PF17213.3 CDJ26832.1 - 0.035 14.4 0.1 0.069 13.4 0.0 1.5 2 0 0 2 2 1 0 Hydin Adenylate kinase-like domain AAA_3 PF07726.11 CDJ26832.1 - 0.036 13.9 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CDJ26832.1 - 0.038 13.3 0.1 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin Thymidylate_kin PF02223.17 CDJ26832.1 - 0.042 13.5 0.3 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase ResIII PF04851.15 CDJ26832.1 - 0.043 13.8 0.1 0.092 12.7 0.1 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit FDX-ACB PF03147.14 CDJ26832.1 - 0.046 14.1 0.3 0.086 13.3 0.3 1.4 1 0 0 1 1 1 0 Ferredoxin-fold anticodon binding domain FtsK_SpoIIIE PF01580.18 CDJ26832.1 - 0.047 13.1 0.1 0.22 10.8 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Peptidase_S68 PF10461.9 CDJ26832.1 - 0.061 13.5 0.2 0.12 12.6 0.2 1.5 1 0 0 1 1 1 0 Peptidase S68 SRP54 PF00448.22 CDJ26832.1 - 0.074 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF2075 PF09848.9 CDJ26832.1 - 0.076 12.2 1.6 0.32 10.2 1.6 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CDJ26832.1 - 0.1 12.2 0.1 0.32 10.5 0.0 1.7 2 1 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 CDJ26832.1 - 0.1 11.8 1.4 0.28 10.3 0.1 2.0 1 1 1 2 2 2 0 Anion-transporting ATPase APS_kinase PF01583.20 CDJ26832.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase MMR_HSR1 PF01926.23 CDJ26832.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Med26 PF08711.11 CDJ26835.1 - 0.013 15.5 0.3 0.031 14.3 0.3 1.6 1 0 0 1 1 1 0 TFIIS helical bundle-like domain DUF3474 PF11960.8 CDJ26836.1 - 1 9.5 7.8 0.69 10.1 1.6 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3474) Herpes_UL3 PF03369.13 CDJ26836.1 - 3.7 8.1 5.7 1.7 9.2 0.1 3.2 2 1 2 4 4 4 0 Herpesvirus UL3 protein # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_acervulina-EAH001/GCA_000499425.1_EAH001_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_acervulina-EAH001/GCA_000499425.1_EAH001_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_acervulina-EAH001/GCA_000499425.1_EAH001_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Eimeria_acervulina-EAH001/GCA_000499425.1_EAH001_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 01:05:36 2019 # [ok]