# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF5074 PF16819.5 EAK87289.1 - 0.41 10.7 4.5 6 7.0 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5074) PcfJ PF14284.6 EAK87290.1 - 0.049 13.5 2.4 13 5.6 0.1 3.1 1 1 2 3 3 3 0 PcfJ-like protein OCC1 PF15506.6 EAK87290.1 - 8.6 6.6 9.8 13 6.0 0.2 2.8 3 0 0 3 3 3 0 OCC1 family Ribosomal_S25 PF03297.15 EAK87291.1 - 0.36 11.1 5.9 0.19 12.0 3.5 1.8 2 0 0 2 2 2 0 S25 ribosomal protein Tudor_2 PF18104.1 EAK87291.1 - 0.77 9.5 3.4 2.3 8.0 0.2 2.7 3 0 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain GATase PF00117.28 EAK87292.1 - 1.4e-25 90.2 0.5 4.5e-25 88.5 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 EAK87292.1 - 2.1e-17 63.0 0.0 8.5e-09 35.4 0.0 2.9 2 1 0 2 2 2 2 GMP synthase C terminal domain NAD_synthase PF02540.17 EAK87292.1 - 1.8e-09 37.1 0.0 5e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EAK87292.1 - 0.0044 16.8 0.3 0.012 15.3 0.3 1.9 1 1 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EAK87292.1 - 0.019 14.5 0.0 0.065 12.7 0.0 1.8 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC ThiI PF02568.14 EAK87292.1 - 0.053 13.1 0.1 0.87 9.1 0.0 2.2 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.21 EAK87292.1 - 0.079 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase CSG2 PF16965.5 EAK87292.1 - 0.52 9.2 4.4 5.1 5.9 0.0 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator Orf78 PF06024.12 EAK87292.1 - 0.54 10.6 18.8 2.8 8.3 10.4 2.7 2 0 0 2 2 2 0 Orf78 (ac78) Peroxin-13_N PF04088.13 EAK87292.1 - 2.7 8.2 4.7 7.9 6.7 1.2 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region AsnA PF03590.15 EAK87293.1 - 9.8e-77 257.7 6.1 1.3e-76 257.3 6.1 1.2 1 0 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.20 EAK87293.1 - 0.0081 15.3 0.4 0.014 14.5 0.4 1.8 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) Choline_kin_N PF04428.14 EAK87293.1 - 0.061 13.0 3.0 0.14 11.9 0.1 2.7 4 0 0 4 4 4 0 Choline kinase N terminus PALP PF00291.25 EAK87294.1 - 7.3e-39 133.9 0.0 8.8e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Myc_N PF01056.18 EAK87296.1 - 0.0032 17.4 4.6 0.0037 17.2 4.6 1.2 1 0 0 1 1 1 1 Myc amino-terminal region Hox9_act PF04617.13 EAK87296.1 - 0.016 15.9 5.1 0.025 15.3 5.1 1.2 1 0 0 1 1 1 0 Hox9 activation region DUF2457 PF10446.9 EAK87296.1 - 0.017 14.3 12.4 0.032 13.4 12.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Paf1 PF03985.13 EAK87296.1 - 0.02 13.9 13.9 0.023 13.7 13.9 1.1 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 EAK87296.1 - 0.023 12.9 11.6 0.025 12.8 11.6 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EAK87296.1 - 0.098 10.9 15.2 0.11 10.7 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein ORC6 PF05460.13 EAK87296.1 - 0.21 10.8 7.7 0.25 10.6 7.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) AAA_11 PF13086.6 EAK87296.1 - 0.21 11.3 5.1 0.27 11.0 5.1 1.2 1 0 0 1 1 1 0 AAA domain Raftlin PF15250.6 EAK87296.1 - 0.24 10.1 7.5 0.32 9.7 7.5 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 EAK87296.1 - 0.34 9.6 8.4 0.4 9.4 8.4 1.2 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 EAK87296.1 - 0.36 11.0 8.8 0.51 10.5 8.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NOA36 PF06524.12 EAK87296.1 - 1 8.7 12.8 1.4 8.2 12.8 1.3 1 0 0 1 1 1 0 NOA36 protein GRP PF07172.11 EAK87296.1 - 1 10.1 18.7 0.35 11.6 3.2 2.5 2 1 0 2 2 2 0 Glycine rich protein family Tmemb_9 PF05434.11 EAK87296.1 - 1.6 8.6 4.1 24 4.8 0.0 2.2 2 0 0 2 2 2 0 TMEM9 SLC12 PF03522.15 EAK87296.1 - 1.6 7.7 7.1 1.9 7.4 7.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 EAK87296.1 - 2.6 7.4 10.5 3.3 7.1 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Hid1 PF12722.7 EAK87296.1 - 2.8 6.0 5.4 2.8 6.0 5.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3408 PF11888.8 EAK87296.1 - 3.5 7.8 13.8 6.2 7.0 13.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) FAM176 PF14851.6 EAK87296.1 - 3.7 7.2 12.1 6.6 6.4 12.1 1.5 1 0 0 1 1 1 0 FAM176 family CobT PF06213.12 EAK87296.1 - 4.8 6.5 16.0 7.3 5.9 16.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 EAK87296.1 - 4.9 5.1 14.7 6.3 4.8 14.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 EAK87296.1 - 5.1 6.8 14.1 7.5 6.3 14.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PPL5 PF18168.1 EAK87296.1 - 6.4 6.0 10.4 9.5 5.4 10.4 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF913 PF06025.12 EAK87296.1 - 6.5 5.6 7.1 8 5.3 7.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GRP PF07172.11 EAK87297.1 - 0.0015 19.2 0.3 0.0015 19.2 0.3 2.3 2 0 0 2 2 2 1 Glycine rich protein family CDC45 PF02724.14 EAK87297.1 - 0.043 12.1 15.0 0.049 11.9 15.0 1.1 1 0 0 1 1 1 0 CDC45-like protein PT PF04886.12 EAK87297.1 - 0.23 11.1 1.5 0.33 10.5 1.5 1.2 1 0 0 1 1 1 0 PT repeat CobT PF06213.12 EAK87297.1 - 2 7.8 15.0 3.1 7.1 15.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 EAK87298.1 - 0.017 13.4 19.4 0.019 13.2 19.4 1.1 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.11 EAK87298.1 - 0.023 14.7 19.3 0.034 14.1 19.3 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 EAK87298.1 - 0.13 10.5 26.0 0.18 10.1 26.0 1.1 1 0 0 1 1 1 0 CDC45-like protein PT PF04886.12 EAK87298.1 - 0.15 11.6 1.3 0.24 11.0 1.3 1.2 1 0 0 1 1 1 0 PT repeat YL1 PF05764.13 EAK87298.1 - 1.5 8.9 28.9 0.21 11.7 25.2 1.4 2 0 0 2 2 2 0 YL1 nuclear protein CobT PF06213.12 EAK87298.1 - 5.7 6.2 21.0 8.7 5.6 21.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Cwf_Cwc_15 PF04889.12 EAK87300.1 - 0.0031 17.3 18.7 0.0041 16.9 18.7 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 EAK87300.1 - 0.057 12.8 18.5 0.073 12.5 18.5 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EAK87300.1 - 0.058 11.6 17.5 0.066 11.4 17.5 1.0 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.10 EAK87300.1 - 0.19 11.1 17.2 0.22 10.9 17.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 EAK87300.1 - 0.37 9.0 20.7 0.48 8.7 20.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 EAK87300.1 - 1.7 7.2 25.2 2 6.9 25.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 EAK87300.1 - 2.7 6.0 21.3 3.4 5.6 21.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 EAK87300.1 - 3.2 7.1 19.8 5 6.4 19.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PTPRCAP PF15713.5 EAK87300.1 - 4.2 7.6 14.7 7.9 6.8 14.7 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Merozoite_SPAM PF07133.11 EAK87301.1 - 0.026 14.5 16.6 0.039 14.0 16.6 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF1002 PF06207.11 EAK87303.1 - 0.036 13.6 2.4 0.09 12.3 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) DSHCT PF08148.12 EAK87306.1 - 1.2e-34 119.3 0.1 3.6e-34 117.8 0.1 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EAK87306.1 - 1.5e-19 70.5 0.1 9e-19 67.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87306.1 - 2.3e-07 31.1 0.1 2.3e-07 31.1 0.1 4.4 4 0 0 4 4 4 1 Helicase conserved C-terminal domain VCX_VCY PF15231.6 EAK87306.1 - 0.13 13.0 11.5 0.34 11.6 11.5 1.7 1 0 0 1 1 1 0 Variable charge X/Y family DUF4407 PF14362.6 EAK87306.1 - 9.3 5.5 6.6 32 3.7 6.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SDA1 PF05285.12 EAK87307.1 - 4.9 6.5 7.0 8.3 5.7 7.0 1.2 1 0 0 1 1 1 0 SDA1 Sec20 PF03908.13 EAK87308.1 - 5.5e-06 26.2 1.5 1e-05 25.3 1.5 1.5 1 0 0 1 1 1 1 Sec20 V-SNARE_C PF12352.8 EAK87308.1 - 4.9e-05 23.5 0.7 7.8e-05 22.9 0.7 1.3 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus eIF3_p135 PF12807.7 EAK87309.1 - 2.7e-05 24.3 0.1 9.8e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 PPP4R2 PF09184.11 EAK87310.1 - 2.1e-08 34.1 0.9 2.1e-08 34.1 0.9 1.9 2 0 0 2 2 2 1 PPP4R2 zf_UBZ PF18439.1 EAK87310.1 - 0.024 14.2 1.0 0.18 11.4 1.0 2.4 1 1 0 1 1 1 0 Ubiquitin-Binding Zinc Finger TRAPPC10 PF12584.8 EAK87312.1 - 0.00089 19.0 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Gryzun-like PF12742.7 EAK87312.1 - 0.016 15.2 0.0 0.044 13.8 0.0 1.8 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking Spindle_Spc25 PF08234.12 EAK87313.1 - 1.3e-16 60.6 2.5 1.3e-16 60.6 2.5 2.5 2 1 0 2 2 2 1 Chromosome segregation protein Spc25 Apolipoprotein PF01442.18 EAK87313.1 - 0.018 14.9 4.3 0.033 14.1 4.3 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 EAK87313.1 - 0.12 12.0 3.7 0.15 11.6 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2935 PF11155.8 EAK87313.1 - 1.1 9.6 7.2 4.2 7.7 4.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Noelin-1 PF12308.8 EAK87313.1 - 1.2 9.2 5.6 0.7 9.9 0.3 2.7 2 1 1 3 3 3 0 Neurogenesis glycoprotein Ribosomal_S13 PF00416.22 EAK87313.1 - 2.3 8.6 6.5 1.5 9.2 3.4 1.9 1 1 0 2 2 2 0 Ribosomal protein S13/S18 CorA PF01544.18 EAK87313.1 - 4.8 6.4 6.6 9.2 5.5 6.6 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein EF-hand_14 PF17959.1 EAK87313.1 - 6.6 7.1 9.3 0.24 11.8 1.8 2.5 2 1 1 3 3 3 0 EF-hand domain MMR_HSR1_Xtn PF16897.5 EAK87314.1 - 1.6e-42 143.8 0.3 2.8e-42 143.0 0.3 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EAK87314.1 - 5.9e-21 74.7 0.0 1.2e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EAK87314.1 - 4.9e-15 55.3 0.0 1.4e-14 53.9 0.0 1.8 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EAK87314.1 - 4.1e-12 45.9 0.0 8e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EAK87314.1 - 0.00017 21.7 0.1 0.077 13.1 0.0 2.3 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 EAK87314.1 - 0.0038 16.7 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EAK87314.1 - 0.0047 17.1 0.1 0.13 12.5 0.0 2.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAK87314.1 - 0.0049 16.3 0.2 0.14 11.6 0.1 2.4 1 1 1 2 2 2 1 ADP-ribosylation factor family AAA_28 PF13521.6 EAK87314.1 - 0.023 14.9 0.1 0.05 13.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EAK87314.1 - 0.23 11.3 1.1 1.2 9.0 0.3 2.5 3 1 0 3 3 3 0 RsgA GTPase zf-CCCH_4 PF18044.1 EAK87315.1 - 3.4e-07 29.9 3.5 8.2e-07 28.7 3.5 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EAK87315.1 - 2.6e-06 27.3 7.7 5.8e-06 26.2 7.7 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EAK87315.1 - 3.3e-06 26.8 1.3 6.8e-06 25.9 1.3 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EAK87315.1 - 0.0023 18.6 0.7 0.0059 17.3 0.7 1.6 1 0 0 1 1 1 1 Torus domain PQQ_3 PF13570.6 EAK87315.1 - 0.16 12.5 0.0 2.2 8.9 0.0 2.7 2 0 0 2 2 2 0 PQQ-like domain zf-CCCH_2 PF14608.6 EAK87315.1 - 0.31 11.6 4.4 0.94 10.0 4.4 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RRP36 PF06102.12 EAK87316.1 - 1.3e-29 103.3 21.2 1.3e-29 103.3 21.2 2.0 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 ZapB PF06005.12 EAK87317.1 - 0.038 14.4 21.1 0.087 13.3 6.8 3.8 2 1 1 3 3 3 0 Cell division protein ZapB FliS PF02561.14 EAK87317.1 - 0.044 14.0 0.1 0.19 12.0 0.1 2.1 1 0 0 1 1 1 0 Flagellar protein FliS DUF1465 PF07323.12 EAK87317.1 - 0.15 11.9 5.4 0.41 10.5 4.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) Prefoldin_2 PF01920.20 EAK87317.1 - 0.73 9.8 13.8 0.41 10.6 10.2 2.5 2 0 0 2 2 2 0 Prefoldin subunit DUF4407 PF14362.6 EAK87317.1 - 1.2 8.4 6.9 2 7.7 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HALZ PF02183.18 EAK87317.1 - 1.6 9.0 10.2 0.4 10.9 0.9 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 EAK87317.1 - 1.8 8.7 12.8 5.3 7.2 3.9 2.7 2 0 0 2 2 2 0 bZIP transcription factor DUF573 PF04504.14 EAK87317.1 - 3 8.5 9.2 0.5 11.1 0.2 3.8 3 1 1 4 4 4 0 Protein of unknown function, DUF573 Agglutinin PF07468.11 EAK87318.1 - 0.069 13.3 0.2 3.4 7.9 0.0 2.7 2 0 0 2 2 2 0 Agglutinin domain DUF1011 PF06237.12 EAK87319.1 - 0.027 14.8 3.8 3.1 8.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) Asn_synthase PF00733.21 EAK87320.1 - 0.00026 20.8 0.1 0.48 10.0 0.0 2.2 2 0 0 2 2 2 2 Asparagine synthase Maf1 PF09174.10 EAK87320.1 - 0.03 14.5 1.3 0.044 13.9 0.2 1.8 2 0 0 2 2 2 0 Maf1 regulator ATP_bind_3 PF01171.20 EAK87320.1 - 0.051 13.3 0.7 0.22 11.3 0.0 2.2 2 0 0 2 2 2 0 PP-loop family Myb_DNA-bind_7 PF15963.5 EAK87321.1 - 0.45 10.5 4.3 0.46 10.4 0.6 2.5 2 0 0 2 2 2 0 Myb DNA-binding like PRR20 PF15708.5 EAK87323.1 - 0.0019 18.2 3.9 0.0019 18.2 3.9 3.3 4 0 0 4 4 4 1 Proline-rich protein family 20 Amelogenin PF02948.15 EAK87323.1 - 0.002 18.8 10.6 0.0036 18.0 10.6 1.4 1 0 0 1 1 1 1 Amelogenin PRP38_assoc PF12871.7 EAK87323.1 - 0.0038 17.8 42.8 0.0038 17.8 42.8 4.3 4 0 0 4 4 4 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term ArfGap PF01412.18 EAK87324.1 - 0.00097 19.2 0.6 0.002 18.2 0.6 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF2318 PF10080.9 EAK87324.1 - 0.065 13.4 1.4 0.16 12.1 0.2 2.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) DUF2576 PF10845.8 EAK87324.1 - 0.078 12.6 0.8 0.26 10.9 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2576) DUF676 PF05057.14 EAK87326.1 - 1.4e-41 142.4 0.0 2.9e-41 141.4 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 EAK87326.1 - 1.1e-17 64.3 1.2 4.9e-17 62.2 1.2 2.3 1 0 0 1 1 1 1 Protein FAM135 PGAP1 PF07819.13 EAK87326.1 - 0.00017 21.4 0.2 0.0088 15.8 0.2 2.3 1 1 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EAK87326.1 - 0.00064 19.6 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 EAK87326.1 - 0.042 14.5 0.0 0.067 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3265 PF11665.8 EAK87327.1 - 0.044 14.0 0.4 0.15 12.3 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3265) AdoHcyase PF05221.17 EAK87329.1 - 2.4e-119 397.9 0.1 2.9e-119 397.7 0.1 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EAK87329.1 - 5.1e-70 234.7 2.2 7.9e-70 234.1 2.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EAK87329.1 - 2.4e-10 40.1 0.1 4.5e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EAK87329.1 - 1.5e-06 27.8 0.3 2.6e-06 27.1 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EAK87329.1 - 3.8e-06 27.0 0.1 1e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EAK87329.1 - 0.00017 21.8 1.3 0.0014 18.9 1.3 2.2 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 EAK87329.1 - 0.00033 21.1 0.1 0.00087 19.7 0.1 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 EAK87329.1 - 0.002 17.5 1.3 0.0081 15.5 1.3 1.9 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AlaDh_PNT_C PF01262.21 EAK87329.1 - 0.0031 16.8 0.7 0.0078 15.5 0.7 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 EAK87329.1 - 0.0069 17.0 0.3 0.014 16.0 0.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Na_H_Exchanger PF00999.21 EAK87330.1 - 8.3e-50 169.7 37.4 1.1e-49 169.2 37.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Macoilin PF09726.9 EAK87333.1 - 0.012 14.2 14.0 0.011 14.3 14.0 1.2 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 EAK87333.1 - 0.48 8.6 3.4 0.49 8.5 3.4 1.0 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.11 EAK87333.1 - 0.57 8.2 18.6 0.59 8.1 18.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Menin PF05053.13 EAK87333.1 - 1.5 7.1 8.9 1.7 7.0 8.9 1.1 1 0 0 1 1 1 0 Menin Tmemb_cc2 PF10267.9 EAK87333.1 - 2.3 7.3 8.1 2.7 7.0 8.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Herpes_capsid PF06112.11 EAK87333.1 - 2.8 8.0 36.4 4.5 7.3 36.4 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SPX PF03105.19 EAK87333.1 - 4.4 7.1 22.8 5 6.9 22.8 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 EAK87333.1 - 6.4 5.5 24.4 7.9 5.2 24.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peroxin-3 PF04882.12 EAK87333.1 - 7.7 5.4 11.1 7.9 5.3 11.1 1.1 1 0 0 1 1 1 0 Peroxin-3 CAP_N PF01213.19 EAK87334.1 - 1.6 8.1 9.3 0.23 10.9 3.6 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EAK87334.1 - 8 6.5 11.5 0.4 10.7 3.6 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Peptidase_M48_N PF16491.5 EAK87335.1 - 1.8e-45 155.1 14.0 1.8e-45 155.1 14.0 2.2 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EAK87335.1 - 7.9e-31 107.4 0.0 1.7e-30 106.3 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_M56 PF05569.11 EAK87335.1 - 0.012 14.9 0.5 0.023 13.9 0.5 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 SprT-like PF10263.9 EAK87335.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 SprT-like family Peptidase_M23 PF01551.22 EAK87336.1 - 0.0052 17.0 4.0 1.5 9.1 0.0 5.9 7 1 1 8 8 8 1 Peptidase family M23 Mitofilin PF09731.9 EAK87336.1 - 7.4 5.3 6.0 12 4.5 6.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CCDC53 PF10152.9 EAK87336.1 - 8.2 6.8 18.2 0.91 9.9 4.7 2.5 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex MS_channel PF00924.18 EAK87337.1 - 3.3e-15 56.2 3.6 6.3e-15 55.3 3.6 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel Malectin PF11721.8 EAK87338.1 - 8.3e-27 94.3 0.2 1.1e-26 93.9 0.2 1.1 1 0 0 1 1 1 1 Malectin domain DUF5081 PF16887.5 EAK87338.1 - 0.038 13.1 0.3 0.067 12.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5081) Na_H_Exchanger PF00999.21 EAK87339.1 - 4.3e-53 180.5 33.8 5.8e-53 180.0 33.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Thioredoxin PF00085.20 EAK87340.1 - 1.5e-54 182.3 0.1 2.9e-27 94.7 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EAK87340.1 - 6.4e-19 68.6 7.3 5.2e-13 49.3 1.3 3.9 4 0 0 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.13 EAK87340.1 - 9.7e-11 41.5 1.7 8.4e-05 22.1 0.1 3.1 2 1 1 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EAK87340.1 - 3.7e-10 40.2 2.5 2.4e-08 34.4 0.1 3.5 3 2 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EAK87340.1 - 5.1e-09 36.3 0.5 0.035 14.4 0.0 5.6 5 2 2 7 7 6 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EAK87340.1 - 6.3e-09 35.9 0.0 0.013 15.7 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 EAK87340.1 - 4.5e-07 29.8 0.4 0.041 13.8 0.0 3.0 3 0 0 3 3 3 2 AhpC/TSA family Calsequestrin PF01216.17 EAK87340.1 - 3.3e-06 26.4 0.1 5.2e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Calsequestrin Redoxin PF08534.10 EAK87340.1 - 0.0017 18.1 0.0 2 8.1 0.0 2.5 2 0 0 2 2 2 2 Redoxin Thioredoxin_9 PF14595.6 EAK87340.1 - 0.0035 17.1 0.0 0.56 10.0 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_5 PF13743.6 EAK87340.1 - 0.08 12.6 1.1 20 4.8 0.1 3.3 3 0 0 3 3 3 0 Thioredoxin Thioredoxin_4 PF13462.6 EAK87340.1 - 0.13 12.4 2.0 20 5.3 0.0 3.6 4 0 0 4 4 4 0 Thioredoxin GLTSCR1 PF15249.6 EAK87341.1 - 7.9e-06 26.2 0.8 1.7e-05 25.2 0.1 2.0 1 1 1 2 2 2 1 Conserved region of unknown function on GLTSCR protein YvrJ PF12841.7 EAK87341.1 - 2 8.0 3.5 7.9 6.1 0.0 2.7 3 0 0 3 3 3 0 YvrJ protein family 30K_MP_core PF17644.1 EAK87342.1 - 0.079 12.8 0.1 0.92 9.4 0.0 2.6 1 1 1 2 2 2 0 Core domain of 30K viral movement proteins PH PF00169.29 EAK87344.1 - 2.5e-07 31.1 1.6 2.5e-07 31.1 1.6 3.3 4 0 0 4 4 4 1 PH domain FCH PF00611.23 EAK87344.1 - 0.02 15.2 0.1 0.096 13.0 0.1 2.3 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain PH_10 PF15411.6 EAK87344.1 - 0.046 14.0 0.1 0.046 14.0 0.1 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain YolD PF08863.10 EAK87344.1 - 1.1 9.3 9.3 0.74 9.9 1.0 3.9 4 1 0 4 4 4 0 YolD-like protein LprI PF07007.12 EAK87344.1 - 1.3 9.7 4.3 3.3 8.4 0.2 3.0 3 0 0 3 3 3 0 Lysozyme inhibitor LprI FliJ PF02050.16 EAK87344.1 - 1.3 9.2 8.5 16 5.7 0.2 3.5 2 1 1 3 3 3 0 Flagellar FliJ protein FOG_N PF15888.5 EAK87345.1 - 1.5e-10 41.4 17.1 0.0036 17.6 0.1 5.9 3 1 2 6 6 6 3 Folded gastrulation N-terminus CPW_WPC PF09717.10 EAK87345.1 - 6.3e-05 23.9 15.0 1.4 10.0 0.1 5.8 4 2 1 5 5 5 3 Plasmodium falciparum domain of unknown function (CPW_WPC) cEGF PF12662.7 EAK87345.1 - 0.016 15.1 14.3 1.5 8.9 0.2 4.9 4 0 0 4 4 4 0 Complement Clr-like EGF-like Antistasin PF02822.14 EAK87345.1 - 0.019 15.6 9.1 21 5.8 0.0 5.8 4 2 0 4 4 4 0 Antistasin family zf-RING_6 PF14835.6 EAK87345.1 - 0.17 11.7 2.2 0.65 9.9 0.2 2.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein CC PF04942.14 EAK87345.1 - 0.22 11.8 0.3 0.22 11.8 0.3 7.3 8 0 0 8 8 8 0 CC domain Tme5_EGF_like PF09064.10 EAK87345.1 - 2.6 8.0 9.7 22 5.1 0.3 4.4 5 0 0 5 5 5 0 Thrombomodulin like fifth domain, EGF-like G-patch_2 PF12656.7 EAK87347.1 - 1.2e-14 54.1 0.1 4.9e-14 52.2 0.0 2.1 2 0 0 2 2 2 1 G-patch domain CC190 PF15768.5 EAK87347.1 - 0.49 10.4 5.9 0.58 10.2 1.6 1.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 190 APG6 PF04111.12 EAK87348.1 - 6.6e-33 114.1 0.5 1.6e-32 112.9 0.0 1.8 2 0 0 2 2 2 1 Apg6 BARA domain BssC_TutF PF08201.11 EAK87348.1 - 0.27 11.3 3.4 0.73 9.9 0.2 2.6 2 0 0 2 2 2 0 BssC/TutF protein Voldacs PF03517.13 EAK87348.1 - 1.3 9.1 9.3 2.4 8.3 9.3 1.3 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DAGAT PF03982.13 EAK87349.1 - 4.2e-19 68.6 0.2 6.8e-19 67.9 0.2 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase End3 PF12761.7 EAK87351.1 - 0.041 14.1 1.2 0.14 12.3 0.9 1.8 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Mg_trans_NIPA PF05653.14 EAK87353.1 - 7.1e-15 54.9 21.0 2.3e-10 40.1 4.1 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EAK87353.1 - 3.3e-05 24.1 6.1 3.3e-05 24.1 6.1 3.2 3 0 0 3 3 3 2 EamA-like transporter family Big_7 PF17957.1 EAK87354.1 - 0.025 15.3 0.7 0.035 14.8 0.7 1.2 1 0 0 1 1 1 0 Bacterial Ig domain HTH_19 PF12844.7 EAK87355.1 - 0.48 10.5 2.7 0.29 11.2 0.6 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain IMPDH PF00478.25 EAK87356.1 - 5.1e-157 522.3 5.7 5.8e-157 522.1 5.7 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EAK87356.1 - 4.6e-11 42.3 13.1 5.4e-10 38.8 6.0 2.6 2 1 1 3 3 3 2 FMN-dependent dehydrogenase NMO PF03060.15 EAK87356.1 - 5.4e-08 32.6 10.0 3.8e-07 29.8 10.0 2.5 1 1 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EAK87356.1 - 1.4e-06 27.9 6.6 3.2e-06 26.8 6.6 1.7 1 1 0 1 1 1 1 Histidine biosynthesis protein Glu_synthase PF01645.17 EAK87356.1 - 3.1e-05 23.3 5.2 3.1e-05 23.3 5.2 1.7 1 1 1 2 2 2 1 Conserved region in glutamate synthase Dus PF01207.17 EAK87356.1 - 0.00072 18.7 2.7 0.035 13.2 0.0 2.8 3 0 0 3 3 3 1 Dihydrouridine synthase (Dus) ThiG PF05690.14 EAK87356.1 - 0.0028 17.0 4.0 0.0052 16.1 0.7 2.2 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EAK87356.1 - 0.0097 15.3 3.5 0.38 10.1 0.2 2.6 2 0 0 2 2 2 2 Glycerol-3-phosphate responsive antiterminator QRPTase_C PF01729.19 EAK87356.1 - 0.02 14.6 0.4 0.048 13.4 0.4 1.6 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain TMP-TENI PF02581.17 EAK87356.1 - 0.073 12.4 4.1 2.9 7.2 0.4 2.8 1 1 2 3 3 3 0 Thiamine monophosphate synthase DHO_dh PF01180.21 EAK87356.1 - 0.43 9.7 7.8 1.2 8.2 7.7 2.0 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase Hist_deacetyl PF00850.19 EAK87357.1 - 4.2e-81 272.8 0.0 5.6e-81 272.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain LRR_4 PF12799.7 EAK87358.1 - 4.2e-23 81.0 52.1 2.4e-06 27.8 0.8 6.7 5 2 0 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EAK87358.1 - 8.8e-17 60.6 33.6 8.2e-07 28.7 2.1 6.4 4 1 3 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 EAK87358.1 - 9.9e-08 31.7 22.1 0.0009 18.8 6.9 3.9 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EAK87358.1 - 0.0097 16.3 38.2 6.3 7.8 0.5 9.3 9 2 0 9 9 9 3 Leucine Rich Repeat DUF2322 PF10084.9 EAK87358.1 - 0.084 12.9 0.6 0.43 10.7 0.2 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2322) MCM PF00493.23 EAK87359.1 - 3e-97 324.1 0.0 4.7e-97 323.5 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EAK87359.1 - 6.5e-37 126.2 0.4 6.5e-37 126.2 0.4 1.7 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 EAK87359.1 - 1e-27 96.4 0.3 2.6e-27 95.1 0.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 EAK87359.1 - 2.9e-17 62.9 5.0 2.9e-17 62.9 5.0 2.4 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 EAK87359.1 - 4.1e-06 27.3 4.3 7.8e-05 23.2 0.0 3.7 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 EAK87359.1 - 5.5e-06 25.9 0.0 1.9e-05 24.1 0.0 1.8 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EAK87359.1 - 1.9e-05 24.7 0.0 4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 EAK87359.1 - 0.039 13.6 0.6 0.075 12.7 0.6 1.4 1 0 0 1 1 1 0 Thymidylate kinase Mg_chelatase_C PF13335.6 EAK87359.1 - 0.05 14.2 0.1 0.27 11.9 0.1 2.4 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal DUF913 PF06025.12 EAK87359.1 - 4.4 6.2 7.9 0.13 11.2 1.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Vps36_ESCRT-II PF11605.8 EAK87360.1 - 0.00012 22.1 0.0 0.00029 20.9 0.0 1.6 1 1 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 EAK87360.1 - 0.028 14.8 0.0 0.048 14.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial PH domain eIF-6 PF01912.18 EAK87360.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 eIF-6 family Apt1 PF10351.9 EAK87361.1 - 0.39 9.5 2.9 0.37 9.6 2.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 EAK87364.1 - 0.18 11.4 13.5 0.27 10.8 13.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EAK87364.1 - 0.32 11.7 17.4 0.088 13.5 12.6 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein Secretin_N PF03958.17 EAK87364.1 - 0.46 10.9 4.0 11 6.5 1.7 2.3 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain Pheromone PF08015.11 EAK87364.1 - 3 8.9 11.4 2.5 9.2 1.7 2.5 3 0 0 3 3 3 0 Fungal mating-type pheromone SPX PF03105.19 EAK87364.1 - 5 6.9 10.7 6.6 6.5 10.7 1.2 1 0 0 1 1 1 0 SPX domain Arm PF00514.23 EAK87368.1 - 3.1e-11 42.9 0.1 0.012 15.6 0.0 4.8 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 EAK87368.1 - 0.043 13.4 0.6 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 Atypical Arm repeat eIF2A PF08662.11 EAK87369.1 - 2.3e-33 115.7 4.6 1.4e-26 93.6 2.8 3.7 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EAK87369.1 - 3.3e-06 27.3 1.5 5.2 7.4 0.0 5.5 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EAK87369.1 - 4.6e-06 27.3 2.4 2 9.5 0.0 5.8 5 1 1 6 6 6 1 WD domain, G-beta repeat Pinin_SDK_memA PF04696.13 EAK87369.1 - 0.028 14.5 1.7 0.059 13.4 1.7 1.5 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region YqbF PF14553.6 EAK87369.1 - 1.5 8.7 3.9 8.6 6.3 0.1 3.2 3 0 0 3 3 3 0 YqbF, hypothetical protein domain BCL_N PF04714.13 EAK87370.1 - 0.15 12.1 4.8 0.9 9.6 0.3 3.8 3 0 0 3 3 3 0 BCL7, N-terminal conserver region FYVE PF01363.21 EAK87370.1 - 0.35 11.0 9.3 5.6 7.2 0.4 4.1 4 0 0 4 4 4 0 FYVE zinc finger Nucleoside_tran PF01733.18 EAK87371.1 - 7.1e-24 84.7 11.4 7.1e-24 84.7 11.4 1.5 2 0 0 2 2 2 1 Nucleoside transporter Kelch_4 PF13418.6 EAK87372.1 - 8.2e-13 48.1 5.7 0.00036 20.5 0.1 5.9 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EAK87372.1 - 6.4e-12 45.4 2.4 4.3e-06 26.9 0.0 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EAK87372.1 - 1.4e-08 34.7 7.6 6.6e-05 23.0 0.1 6.1 5 1 1 6 6 6 1 Kelch motif Kelch_5 PF13854.6 EAK87372.1 - 5.7e-08 32.6 0.0 0.0098 15.9 0.0 4.3 4 0 0 4 4 4 2 Kelch motif HATPase_c_3 PF13589.6 EAK87372.1 - 2e-06 27.7 0.0 6e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Morc6_S5 PF17942.1 EAK87372.1 - 2.6e-05 24.3 0.4 0.04 14.0 0.0 2.7 2 0 0 2 2 2 2 Morc6 ribosomal protein S5 domain 2-like Kelch_1 PF01344.25 EAK87372.1 - 0.0028 17.2 0.1 0.019 14.6 0.0 2.5 3 0 0 3 3 3 1 Kelch motif HATPase_c PF02518.26 EAK87372.1 - 0.0035 17.8 0.0 0.008 16.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_2 PF07646.15 EAK87372.1 - 0.17 11.9 5.0 15 5.7 0.0 4.9 6 0 0 6 6 6 0 Kelch motif UPF0176_N PF17773.1 EAK87373.1 - 0.24 11.8 1.5 1 9.7 0.3 2.1 2 0 0 2 2 2 0 UPF0176 acylphosphatase like domain DUF3130 PF11328.8 EAK87373.1 - 1.1 9.5 5.0 1.4 9.2 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3130 Ribosomal_L15e PF00827.17 EAK87374.1 - 2.6e-87 291.5 7.1 3e-87 291.3 7.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 eIF-3_zeta PF05091.12 EAK87375.1 - 1.5e-152 509.2 0.8 1.8e-152 509.0 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 EAK87375.1 - 0.01 15.4 0.7 0.014 14.9 0.0 1.7 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus His_binding PF02098.16 EAK87376.1 - 0.043 13.8 1.1 0.043 13.8 1.1 1.9 2 0 0 2 2 2 0 Tick histamine binding protein V-ATPase_G PF03179.15 EAK87377.1 - 1.9e-19 70.1 8.0 2.2e-19 69.9 8.0 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit MAT1 PF06391.13 EAK87377.1 - 0.0022 17.9 3.2 0.0031 17.4 3.2 1.3 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 DcrB PF08786.11 EAK87377.1 - 0.0072 16.4 0.1 0.0095 16.0 0.1 1.3 1 1 0 1 1 1 1 DcrB ABC_tran PF00005.27 EAK87377.1 - 0.1 13.1 0.2 0.11 13.0 0.2 1.2 1 0 0 1 1 1 0 ABC transporter MIS13 PF08202.11 EAK87377.1 - 0.21 10.9 4.9 0.25 10.6 4.9 1.1 1 0 0 1 1 1 0 Mis12-Mtw1 protein family ATP-synt_B PF00430.18 EAK87377.1 - 0.28 11.3 10.7 0.32 11.1 7.8 1.9 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Syja_N PF02383.18 EAK87379.1 - 1.3e-61 208.7 0.0 4e-61 207.1 0.0 1.9 1 1 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EAK87379.1 - 0.00032 20.3 0.0 0.00078 19.0 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.16 EAK87380.1 - 5.7e-30 103.1 0.1 1.7e-29 101.6 0.1 1.9 1 0 0 1 1 1 1 YEATS family UME PF08064.13 EAK87380.1 - 0.023 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 UME (NUC010) domain NAD_Gly3P_dh_N PF01210.23 EAK87381.1 - 1.1e-42 145.7 0.0 1.5e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EAK87381.1 - 8.5e-32 110.4 0.0 1.3e-31 109.8 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Got1 PF04178.12 EAK87382.1 - 4.6e-15 56.0 14.7 5.7e-15 55.7 14.7 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF308 PF03729.13 EAK87382.1 - 0.018 15.4 8.0 0.018 15.4 8.0 2.2 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) UL20 PF17582.2 EAK87382.1 - 0.027 13.8 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL20 DUF2157 PF09925.9 EAK87382.1 - 0.1 12.4 4.2 0.14 11.9 4.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) BCAS2 PF05700.11 EAK87383.1 - 1.8e-08 34.3 11.7 1.4e-07 31.5 8.2 2.2 1 1 1 2 2 2 2 Breast carcinoma amplified sequence 2 (BCAS2) LRRFIP PF09738.9 EAK87383.1 - 0.21 11.0 20.9 3.4 7.1 21.2 2.0 1 1 0 1 1 1 0 LRRFIP family Spore_III_AB PF09548.10 EAK87383.1 - 2.2 8.4 14.9 38 4.3 14.9 2.1 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Brix PF04427.18 EAK87384.1 - 8.5e-30 104.3 0.1 1.6e-29 103.4 0.1 1.5 1 0 0 1 1 1 1 Brix domain Mitofilin PF09731.9 EAK87384.1 - 0.73 8.6 15.5 0.99 8.2 15.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Borrelia_P83 PF05262.11 EAK87384.1 - 1.7 7.0 16.4 2.3 6.6 16.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein R3H PF01424.22 EAK87385.1 - 0.00034 20.6 0.5 0.013 15.5 0.0 3.0 3 0 0 3 3 3 1 R3H domain R3H-assoc PF13902.6 EAK87385.1 - 0.015 15.6 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 R3H-associated N-terminal domain Ribosomal_60s PF00428.19 EAK87386.1 - 5.5e-21 74.9 1.8 6.5e-21 74.7 1.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein ABC_tran PF00005.27 EAK87388.1 - 5.6e-31 107.9 0.0 1.9e-15 57.6 0.0 3.1 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EAK87388.1 - 1.1e-30 107.3 28.3 2.8e-24 86.2 5.7 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region MMR_HSR1 PF01926.23 EAK87388.1 - 2e-07 31.1 0.0 0.023 14.8 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 EAK87388.1 - 1.7e-06 27.3 0.5 0.024 13.7 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 EAK87388.1 - 3.3e-06 27.6 0.0 0.0012 19.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EAK87388.1 - 5.1e-06 26.1 0.3 0.041 13.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EAK87388.1 - 7.3e-06 25.5 0.0 0.0046 16.3 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 EAK87388.1 - 1.2e-05 25.2 0.4 0.0026 17.7 0.1 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EAK87388.1 - 1.3e-05 25.2 1.4 0.014 15.2 0.1 4.3 5 0 0 5 5 4 1 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.23 EAK87388.1 - 1.4e-05 25.2 0.5 0.14 12.2 0.1 2.8 2 0 0 2 2 2 2 Dynamin family NACHT PF05729.12 EAK87388.1 - 6.5e-05 22.9 0.3 0.11 12.4 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 EAK87388.1 - 7.3e-05 23.1 0.2 0.11 12.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EAK87388.1 - 0.00014 22.0 4.2 0.0059 16.7 0.1 3.0 2 1 1 3 3 3 1 Helicase HerA, central domain AAA_30 PF13604.6 EAK87388.1 - 0.00018 21.3 0.1 0.12 12.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EAK87388.1 - 0.00077 19.0 1.2 0.19 11.2 0.1 3.3 3 0 0 3 3 3 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EAK87388.1 - 0.0011 18.4 0.0 5.6 6.3 0.0 3.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI SMC_N PF02463.19 EAK87388.1 - 0.0012 18.3 2.0 1.8 8.0 0.2 3.5 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain ATP_bind_1 PF03029.17 EAK87388.1 - 0.0028 17.5 0.2 3.1 7.5 0.0 2.6 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein GvpD PF07088.11 EAK87388.1 - 0.003 16.2 0.0 0.0054 15.4 0.0 1.3 1 0 0 1 1 1 1 GvpD gas vesicle protein AAA_33 PF13671.6 EAK87388.1 - 0.0037 17.4 0.1 2.2 8.4 0.0 3.3 4 0 0 4 4 3 1 AAA domain Zeta_toxin PF06414.12 EAK87388.1 - 0.0041 16.4 0.0 0.031 13.5 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin cobW PF02492.19 EAK87388.1 - 0.0042 16.7 1.3 0.091 12.3 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 EAK87388.1 - 0.0044 17.4 0.7 0.19 12.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EAK87388.1 - 0.006 16.9 0.1 0.65 10.4 0.0 3.0 2 0 0 2 2 2 1 RNA helicase TrwB_AAD_bind PF10412.9 EAK87388.1 - 0.0088 15.0 0.5 2.9 6.7 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 EAK87388.1 - 0.01 16.4 2.9 4.8 7.7 0.0 4.0 4 0 0 4 4 3 0 AAA domain NTPase_1 PF03266.15 EAK87388.1 - 0.014 15.3 0.6 1.6 8.6 0.0 2.6 2 0 0 2 2 2 0 NTPase NB-ARC PF00931.22 EAK87388.1 - 0.014 14.6 0.2 4.4 6.4 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Viral_helicase1 PF01443.18 EAK87388.1 - 0.015 15.0 0.0 4.6 6.9 0.0 2.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 EAK87388.1 - 0.02 13.9 0.1 0.76 8.7 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB UvrD-helicase PF00580.21 EAK87388.1 - 0.023 14.2 0.6 0.28 10.7 0.1 2.5 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AIG1 PF04548.16 EAK87388.1 - 0.041 13.2 0.3 3.6 6.9 0.0 2.7 2 0 0 2 2 2 0 AIG1 family AAA PF00004.29 EAK87388.1 - 0.043 14.3 0.1 0.29 11.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 EAK87388.1 - 0.045 13.0 0.0 0.95 8.7 0.0 2.3 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.9 EAK87388.1 - 0.049 13.4 0.2 5.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 EAK87388.1 - 0.05 13.8 0.7 0.95 9.7 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EAK87388.1 - 0.069 13.1 0.0 4.3 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EAK87388.1 - 0.069 12.7 0.0 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EAK87388.1 - 0.078 12.7 0.1 7 6.3 0.0 2.8 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 EAK87388.1 - 0.11 12.2 0.0 3.9 7.2 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 EAK87388.1 - 0.14 12.2 0.1 14 5.7 0.0 2.7 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.14 EAK87388.1 - 0.28 11.1 0.8 9.8 6.1 0.0 2.7 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.6 EAK87388.1 - 1.2 9.6 14.7 0.64 10.5 0.1 4.2 3 1 1 4 4 3 0 AAA domain RseC_MucC PF04246.12 EAK87388.1 - 7.9 6.4 8.1 16 5.5 2.1 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC ABC_tran PF00005.27 EAK87389.1 - 3.5e-33 115.0 0.0 1.4e-15 58.1 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EAK87389.1 - 9.5e-12 45.1 24.2 9.9e-10 38.5 11.4 3.2 4 0 0 4 4 3 2 ABC transporter transmembrane region MMR_HSR1 PF01926.23 EAK87389.1 - 1.3e-08 34.9 0.0 0.0036 17.4 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EAK87389.1 - 1.5e-07 31.9 0.0 5.6e-05 23.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EAK87389.1 - 1.8e-06 27.6 0.0 0.084 12.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RNA_helicase PF00910.22 EAK87389.1 - 8.4e-06 26.1 0.0 0.0037 17.6 0.0 3.1 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 EAK87389.1 - 1.7e-05 25.1 0.0 0.011 16.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EAK87389.1 - 3.7e-05 23.7 0.0 0.043 13.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase DUF815 PF05673.13 EAK87389.1 - 0.00012 21.4 0.4 0.008 15.4 0.0 3.0 4 0 0 4 4 3 1 Protein of unknown function (DUF815) SMC_N PF02463.19 EAK87389.1 - 0.00013 21.4 0.1 0.25 10.8 0.0 3.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Viral_helicase1 PF01443.18 EAK87389.1 - 0.0011 18.7 0.0 0.045 13.5 0.0 2.8 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 EAK87389.1 - 0.0012 18.8 1.4 0.031 14.2 0.0 3.1 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 EAK87389.1 - 0.0014 17.7 0.0 1.1 8.3 0.0 2.6 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_7 PF12775.7 EAK87389.1 - 0.0016 18.0 0.0 0.16 11.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 EAK87389.1 - 0.002 18.5 0.0 0.01 16.3 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 EAK87389.1 - 0.0021 17.1 0.0 0.25 10.3 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EAK87389.1 - 0.0021 17.3 0.0 0.59 9.3 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 EAK87389.1 - 0.0026 17.1 0.0 0.024 13.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 EAK87389.1 - 0.0027 17.7 0.0 0.47 10.4 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 EAK87389.1 - 0.0029 17.6 0.0 0.22 11.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EAK87389.1 - 0.0038 17.4 0.1 0.22 11.6 0.1 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EAK87389.1 - 0.0063 15.9 0.0 0.036 13.4 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family NTPase_1 PF03266.15 EAK87389.1 - 0.0089 16.0 0.1 1.8 8.5 0.0 2.5 2 0 0 2 2 2 1 NTPase IstB_IS21 PF01695.17 EAK87389.1 - 0.015 15.0 0.0 1.1 9.0 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EAK87389.1 - 0.02 14.3 0.0 1.9 7.8 0.0 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EAK87389.1 - 0.024 14.8 0.1 12 6.0 0.1 2.7 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EAK87389.1 - 0.026 14.4 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_24 PF13479.6 EAK87389.1 - 0.056 13.2 0.0 10 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EAK87389.1 - 0.072 13.3 0.0 2.5 8.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EAK87389.1 - 0.073 13.6 4.9 6.8 7.3 0.0 3.8 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EAK87389.1 - 0.11 12.2 0.0 18 5.0 0.0 2.5 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EAK87389.1 - 0.12 12.1 0.0 11 5.6 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain ATP_bind_1 PF03029.17 EAK87389.1 - 0.13 12.1 0.0 1.4 8.6 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EAK87389.1 - 0.13 12.3 6.4 3.9 7.5 0.0 3.2 3 0 0 3 3 2 0 Dynamin family TrwB_AAD_bind PF10412.9 EAK87389.1 - 0.22 10.4 0.0 21 3.9 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain PRK PF00485.18 EAK87389.1 - 2.4 7.9 5.7 6.2 6.5 0.1 3.4 3 1 1 4 4 4 0 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 EAK87390.1 - 1.6e-27 96.7 0.1 4.2e-14 53.2 0.0 2.9 2 1 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 EAK87390.1 - 1.1e-07 32.0 2.8 0.0036 17.2 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EAK87390.1 - 2.1e-07 30.6 1.2 0.0067 16.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Septin PF00735.18 EAK87390.1 - 3.4e-05 23.3 1.8 0.47 9.7 0.0 3.6 3 0 0 3 3 3 1 Septin AAA_16 PF13191.6 EAK87390.1 - 4.8e-05 23.8 0.0 0.18 12.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EAK87390.1 - 6.7e-05 22.5 0.9 0.059 12.9 0.0 2.8 3 0 0 3 3 2 2 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EAK87390.1 - 6.7e-05 22.3 0.7 0.08 12.3 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.6 EAK87390.1 - 9.1e-05 22.8 0.0 0.2 12.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EAK87390.1 - 0.00011 22.2 0.8 0.032 14.1 0.0 2.9 3 0 0 3 3 3 1 NACHT domain MMR_HSR1 PF01926.23 EAK87390.1 - 0.00023 21.2 4.7 0.012 15.7 1.2 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EAK87390.1 - 0.00049 20.3 0.3 0.57 10.4 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EAK87390.1 - 0.00063 19.5 0.6 0.36 10.6 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EAK87390.1 - 0.00087 19.1 0.0 0.068 12.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EAK87390.1 - 0.0015 18.9 6.4 0.81 10.1 0.0 4.4 4 0 0 4 4 4 2 RNA helicase DUF87 PF01935.17 EAK87390.1 - 0.0019 18.3 2.9 0.38 10.8 1.6 3.2 2 0 0 2 2 2 1 Helicase HerA, central domain Viral_helicase1 PF01443.18 EAK87390.1 - 0.0023 17.7 0.0 1.6 8.4 0.0 2.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 EAK87390.1 - 0.003 17.5 9.5 0.036 14.0 0.0 3.7 4 1 0 4 4 2 2 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EAK87390.1 - 0.0055 15.9 1.3 2.3 7.3 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Dynamin_N PF00350.23 EAK87390.1 - 0.0059 16.7 1.0 0.0059 16.7 1.0 3.9 4 1 0 4 4 4 1 Dynamin family AAA_18 PF13238.6 EAK87390.1 - 0.0071 16.9 0.2 1.7 9.2 0.0 3.2 3 0 0 3 3 2 1 AAA domain cobW PF02492.19 EAK87390.1 - 0.013 15.1 2.4 3.8 7.1 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EAK87390.1 - 0.02 15.0 0.0 0.68 10.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EAK87390.1 - 0.022 14.2 13.7 1.2 8.5 1.5 4.0 3 1 0 4 4 4 0 RecF/RecN/SMC N terminal domain ATP_bind_1 PF03029.17 EAK87390.1 - 0.022 14.5 0.0 2.7 7.7 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 EAK87390.1 - 0.027 14.8 0.1 6.4 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EAK87390.1 - 0.034 14.0 0.5 0.48 10.3 0.0 2.4 2 0 0 2 2 2 0 NTPase T2SSE PF00437.20 EAK87390.1 - 0.046 12.8 0.2 6.5 5.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ATP-synt_ab PF00006.25 EAK87390.1 - 0.049 13.3 0.1 2.9 7.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 EAK87390.1 - 0.061 12.5 0.4 0.77 8.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TsaE PF02367.17 EAK87390.1 - 0.065 13.2 1.8 0.74 9.8 0.0 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DEAD PF00270.29 EAK87390.1 - 0.067 13.0 0.0 2.5 7.8 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase MobB PF03205.14 EAK87390.1 - 0.1 12.5 2.1 2.3 8.1 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activat PF00158.26 EAK87390.1 - 0.11 12.2 0.1 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EAK87390.1 - 0.12 11.8 0.0 20 4.5 0.0 2.5 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EAK87390.1 - 0.28 10.9 0.0 32 4.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.16 EAK87390.1 - 0.32 10.3 4.1 0.21 10.9 1.5 2.0 2 0 0 2 2 2 0 AIG1 family Nop PF01798.18 EAK87391.1 - 1.6e-80 269.9 0.6 1.6e-80 269.9 0.6 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EAK87391.1 - 2.3e-11 43.9 0.0 2.3e-11 43.9 0.0 2.8 3 0 0 3 3 3 1 NOP5NT (NUC127) domain Pep1_7 PF17232.2 EAK87391.1 - 3.8 8.1 8.5 9 6.8 8.5 1.7 1 0 0 1 1 1 0 Elicitor peptide 1-7 RP-C_C PF11800.8 EAK87391.1 - 6.4 6.8 8.3 12 6.0 8.3 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region ALMT PF11744.8 EAK87391.1 - 6.9 5.4 7.8 15 4.3 7.8 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-GRF PF06839.12 EAK87392.1 - 6.4e-11 42.2 3.3 1.6e-10 40.9 3.3 1.7 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos PF03372.23 EAK87392.1 - 3.6e-09 36.5 0.0 1.7e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EAK87392.1 - 4.8e-06 26.4 3.4 0.025 14.4 0.0 3.3 4 0 0 4 4 4 2 Endonuclease-reverse transcriptase Swi6_N PF18530.1 EAK87392.1 - 0.046 13.8 3.8 0.64 10.2 0.2 2.5 1 1 1 2 2 2 0 Swi6 N-terminal domain Aminotran_5 PF00266.19 EAK87393.1 - 8.8e-36 123.6 0.0 1.5e-35 122.8 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V JmjN PF02375.17 EAK87394.1 - 0.025 14.5 0.5 0.79 9.7 0.0 2.8 2 0 0 2 2 2 0 jmjN domain Protamine_3 PF08188.11 EAK87394.1 - 0.15 12.3 3.0 0.84 9.9 0.1 3.0 2 0 0 2 2 2 0 Spermatozal protamine family Ribosomal_L39 PF00832.20 EAK87395.1 - 3.9e-20 71.2 7.8 4.4e-20 71.0 7.8 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein NPL PF17800.1 EAK87396.1 - 6.5e-14 52.4 0.0 6.5e-14 52.4 0.0 3.0 2 1 0 2 2 2 1 Nucleoplasmin-like domain Drc1-Sld2 PF11719.8 EAK87396.1 - 9.7 5.6 37.4 15 5.0 37.4 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein Ribosomal_S24e PF01282.19 EAK87397.1 - 3e-28 97.6 0.0 5.6e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e HSP70 PF00012.20 EAK87398.1 - 1.5e-262 872.1 6.0 1.8e-262 871.9 6.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EAK87398.1 - 2.8e-16 59.3 0.1 1.8e-14 53.3 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DDR PF08841.10 EAK87398.1 - 0.033 13.2 0.3 0.35 9.8 0.1 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 EAK87398.1 - 0.045 13.0 0.3 0.13 11.5 0.1 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DUF494 PF04361.13 EAK87398.1 - 0.075 12.9 0.6 0.15 12.0 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF494) MutS_III PF05192.18 EAK87398.1 - 0.078 13.2 3.6 2.3 8.4 2.2 2.2 2 0 0 2 2 2 0 MutS domain III PKK PF12474.8 EAK87398.1 - 0.11 12.6 15.9 0.2 11.8 11.7 2.3 2 0 0 2 2 2 0 Polo kinase kinase DEAD PF00270.29 EAK87399.1 - 5.9e-34 117.4 0.3 3.4e-33 114.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87399.1 - 7.5e-24 84.2 9.1 1.3e-22 80.2 0.4 4.4 3 1 1 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK87399.1 - 1.9e-13 50.7 8.5 2.8e-13 50.2 0.0 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EAK87399.1 - 0.0045 17.3 0.0 0.041 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain SecA_DEAD PF07517.14 EAK87399.1 - 0.016 14.5 1.7 0.12 11.6 0.1 2.7 2 1 0 2 2 2 0 SecA DEAD-like domain AAA_22 PF13401.6 EAK87399.1 - 0.078 13.3 0.8 0.44 10.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain Helicase_C_2 PF13307.6 EAK87399.1 - 0.53 10.4 2.7 1 9.5 0.5 2.4 2 1 0 2 2 2 0 Helicase C-terminal domain AHSA1 PF08327.11 EAK87400.1 - 3.3e-17 62.9 0.0 3.7e-17 62.7 0.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein RAMP4 PF06624.12 EAK87401.1 - 1.9e-21 75.8 0.2 2.1e-21 75.7 0.2 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF5321 PF17254.2 EAK87401.1 - 0.097 12.1 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5321) RSRP PF17069.5 EAK87403.1 - 0.00013 21.6 47.5 0.00013 21.6 47.5 2.6 2 1 0 2 2 2 1 Arginine/Serine-Rich protein 1 Aa_trans PF01490.18 EAK87405.1 - 2.4e-45 155.0 44.0 3.3e-45 154.5 44.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PAP_PilO PF06864.12 EAK87406.1 - 0.011 14.6 1.0 0.013 14.4 1.0 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Lyase_catalyt PF09093.11 EAK87406.1 - 0.07 12.3 7.0 0.095 11.8 7.0 1.1 1 0 0 1 1 1 0 Lyase, catalytic Sigma70_ner PF04546.13 EAK87406.1 - 0.75 9.6 18.4 0.54 10.1 7.0 2.0 1 1 1 2 2 2 0 Sigma-70, non-essential region eIF3_N PF09440.10 EAK87406.1 - 8.5 6.8 12.8 6.3 7.3 2.4 2.1 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain PHD PF00628.29 EAK87407.1 - 1.8e-13 50.2 4.3 1.8e-13 50.2 4.3 2.8 3 0 0 3 3 3 1 PHD-finger Prok-RING_4 PF14447.6 EAK87407.1 - 5.6e-06 26.1 4.1 5.6e-06 26.1 4.1 2.6 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EAK87407.1 - 2e-05 24.8 4.4 2e-05 24.8 4.4 3.5 3 0 0 3 3 3 2 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EAK87407.1 - 3.3e-05 24.1 4.5 3.3e-05 24.1 4.5 3.4 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_3 PF13920.6 EAK87407.1 - 9.8e-05 22.1 3.7 9.8e-05 22.1 3.7 3.2 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK87407.1 - 0.00012 21.8 4.9 0.00012 21.8 4.9 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK87407.1 - 0.00057 19.7 5.1 0.00057 19.7 5.1 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK87407.1 - 0.0041 17.1 4.2 0.0041 17.1 4.2 3.1 4 1 0 4 4 3 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EAK87407.1 - 0.05 13.7 10.7 0.036 14.1 1.0 2.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD_2 PF13831.6 EAK87407.1 - 0.5 10.0 3.4 0.3 10.7 0.9 2.1 2 0 0 2 2 2 0 PHD-finger zf-RING_6 PF14835.6 EAK87407.1 - 7.8 6.5 6.8 0.67 9.9 1.2 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 EAK87407.1 - 9.9 6.0 8.0 20 5.0 1.8 2.9 2 0 0 2 2 2 0 RING-like zinc finger PKcGMP_CC PF16808.5 EAK87409.1 - 1.6e-05 24.7 0.7 5.3e-05 23.0 0.7 1.9 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2968 PF11180.8 EAK87409.1 - 0.00021 20.9 2.0 0.00041 20.0 2.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) DUF641 PF04859.12 EAK87409.1 - 0.0019 18.5 1.4 0.0019 18.5 1.4 2.6 2 1 1 3 3 3 1 Plant protein of unknown function (DUF641) ADIP PF11559.8 EAK87409.1 - 0.0048 17.0 6.7 0.011 15.8 6.7 1.6 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 EAK87409.1 - 0.012 16.1 11.9 0.089 13.3 9.4 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF3848 PF12959.7 EAK87409.1 - 0.015 15.4 4.8 0.085 12.9 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) NPV_P10 PF05531.12 EAK87409.1 - 0.025 15.0 0.4 0.073 13.5 0.4 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein HMMR_N PF15905.5 EAK87409.1 - 0.035 13.6 10.2 0.039 13.4 9.3 1.4 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal USP8_interact PF08941.10 EAK87409.1 - 0.042 13.7 0.6 0.085 12.7 0.6 1.5 1 0 0 1 1 1 0 USP8 interacting Cortex-I_coil PF09304.10 EAK87409.1 - 0.056 13.7 13.0 0.26 11.5 2.3 3.0 1 1 2 3 3 3 0 Cortexillin I, coiled coil Tropomyosin_1 PF12718.7 EAK87409.1 - 0.12 12.5 14.0 0.23 11.6 14.0 1.4 1 0 0 1 1 1 0 Tropomyosin like Fib_alpha PF08702.10 EAK87409.1 - 0.22 11.7 11.1 0.063 13.5 2.0 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family NYD-SP28_assoc PF14775.6 EAK87409.1 - 0.36 11.0 6.3 0.8 9.9 0.2 3.0 2 1 0 2 2 2 0 Sperm tail C-terminal domain RRP36 PF06102.12 EAK87409.1 - 0.43 10.5 5.5 0.69 9.9 5.5 1.4 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 UPF0242 PF06785.11 EAK87409.1 - 0.45 10.6 10.7 1.7 8.7 10.4 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 EAK87409.1 - 0.62 9.6 4.3 0.96 9.0 4.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CSN5_C PF18323.1 EAK87409.1 - 0.63 11.0 4.2 0.39 11.7 1.8 1.9 2 0 0 2 2 1 0 Cop9 signalosome subunit 5 C-terminal domain DUF16 PF01519.16 EAK87409.1 - 2.1 8.9 8.0 0.61 10.6 3.6 2.3 2 1 1 3 3 3 0 Protein of unknown function DUF16 Bap31_Bap29_C PF18035.1 EAK87409.1 - 2.8 8.0 8.2 1.3 9.1 4.7 2.3 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain TMPIT PF07851.13 EAK87409.1 - 3.3 6.9 6.5 1.4 8.1 3.7 1.6 1 1 1 2 2 2 0 TMPIT-like protein FapA PF03961.13 EAK87409.1 - 5 5.6 9.4 5.2 5.6 8.4 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A Takusan PF04822.13 EAK87409.1 - 9.2 6.2 10.4 0.83 9.6 4.8 2.2 2 1 1 3 3 3 0 Takusan DUF2587 PF10759.9 EAK87410.1 - 0.083 12.4 0.1 0.2 11.1 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2587) Ly49 PF08391.10 EAK87411.1 - 0.44 10.9 4.8 0.62 10.4 1.2 2.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region zf-RING_2 PF13639.6 EAK87412.1 - 4.9e-08 33.2 9.3 2.3e-07 31.0 9.3 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EAK87412.1 - 7.3e-08 32.3 2.0 1.3e-07 31.5 1.2 2.0 1 1 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EAK87412.1 - 5.5e-07 29.1 2.1 5.5e-07 29.1 2.1 1.8 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EAK87412.1 - 4.1e-06 26.4 3.0 1e-05 25.1 3.0 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EAK87412.1 - 7.4e-06 25.7 5.7 4.9e-05 23.1 5.7 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK87412.1 - 9.4e-06 25.4 3.4 9.4e-06 25.4 3.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EAK87412.1 - 1.6e-05 25.1 8.3 0.00017 21.8 8.3 2.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EAK87412.1 - 0.00012 22.0 4.1 0.00036 20.4 4.1 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EAK87412.1 - 0.0013 18.8 1.7 0.0013 18.8 1.7 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Zf_RING PF16744.5 EAK87412.1 - 0.0014 18.7 1.3 0.007 16.4 1.3 2.2 1 0 0 1 1 1 1 KIAA1045 RING finger zf-ANAPC11 PF12861.7 EAK87412.1 - 0.017 15.1 1.2 0.017 15.1 1.2 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 EAK87412.1 - 0.11 12.7 3.5 0.28 11.3 3.5 1.8 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_3 PF13920.6 EAK87412.1 - 0.14 12.1 6.8 1.2 9.0 2.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EAK87412.1 - 2.1 8.6 8.4 12 6.1 8.4 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 EAK87412.1 - 3.2 7.7 10.4 1.2 9.0 3.4 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 AAA_22 PF13401.6 EAK87413.1 - 7.2e-14 52.2 0.0 1.5e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EAK87413.1 - 1.4e-12 48.2 0.0 3.1e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EAK87413.1 - 7.9e-07 29.6 0.0 6.4e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_lid_10 PF17872.1 EAK87413.1 - 4.1e-06 26.8 0.6 1.2e-05 25.4 0.6 1.8 1 0 0 1 1 1 1 AAA lid domain TniB PF05621.11 EAK87413.1 - 5.5e-05 22.7 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_24 PF13479.6 EAK87413.1 - 0.0026 17.5 0.2 0.011 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EAK87413.1 - 0.0034 16.7 0.0 0.0075 15.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EAK87413.1 - 0.044 13.6 0.0 0.044 13.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EAK87413.1 - 0.15 12.4 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.12 EAK87414.1 - 0.00046 20.2 34.6 0.12 12.4 1.3 4.8 4 1 1 5 5 5 3 Protein of unknown function (DUF1664) ATG16 PF08614.11 EAK87414.1 - 0.001 19.3 53.5 0.0042 17.3 20.5 3.4 3 0 0 3 3 3 2 Autophagy protein 16 (ATG16) SlyX PF04102.12 EAK87414.1 - 0.0029 18.2 7.0 0.0029 18.2 7.0 7.5 5 2 2 8 8 8 2 SlyX SHE3 PF17078.5 EAK87414.1 - 0.0084 15.8 18.0 0.0084 15.8 18.0 3.8 4 0 0 4 4 4 2 SWI5-dependent HO expression protein 3 GAS PF13851.6 EAK87414.1 - 0.054 12.8 58.4 0.17 11.2 9.6 4.2 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Bacillus_HBL PF05791.11 EAK87414.1 - 0.68 9.7 36.8 0.064 13.1 8.2 4.4 3 2 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) DUF4988 PF16378.5 EAK87414.1 - 1.2 8.7 21.3 0.3 10.7 0.3 3.9 4 0 0 4 4 4 0 Domain of unknown function Yuri_gagarin PF15934.5 EAK87414.1 - 4.8 7.0 34.5 0.014 15.2 12.5 3.2 3 0 0 3 3 3 0 Yuri gagarin HOOK PF05622.12 EAK87414.1 - 5.9 4.9 59.9 0.61 8.2 18.0 4.5 2 1 2 4 4 4 0 HOOK protein Sugarporin_N PF11471.8 EAK87414.1 - 9.7 6.2 10.6 5.3 7.1 1.7 2.8 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension DAGK_acc PF00609.19 EAK87416.1 - 2.1e-31 109.4 0.3 1.3e-28 100.3 0.3 2.2 1 1 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EAK87416.1 - 5.5e-17 61.6 0.0 1e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Citrus_P18 PF05520.11 EAK87416.1 - 0.064 13.0 1.5 0.21 11.3 0.4 2.1 2 0 0 2 2 2 0 Citrus tristeza virus P18 protein zf-RING_2 PF13639.6 EAK87417.1 - 8.4e-12 45.2 13.5 1.5e-11 44.4 13.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EAK87417.1 - 6.1e-09 35.6 8.2 1.1e-08 34.8 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK87417.1 - 1.8e-08 34.1 12.2 3.1e-08 33.3 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK87417.1 - 3.8e-08 33.1 11.6 7.5e-08 32.1 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK87417.1 - 4.2e-07 29.9 11.3 1.1e-06 28.6 5.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAK87417.1 - 7.8e-07 29.0 9.7 1.4e-06 28.1 9.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EAK87417.1 - 8.7e-06 25.4 8.5 8.7e-06 25.4 8.5 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EAK87417.1 - 8.9e-06 25.9 9.7 2.3e-05 24.6 9.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EAK87417.1 - 0.00014 21.6 9.4 0.00029 20.7 9.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EAK87417.1 - 0.024 14.7 4.9 0.05 13.7 4.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EAK87417.1 - 0.024 14.5 4.1 0.055 13.3 4.1 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EAK87417.1 - 0.36 11.0 12.4 2.6 8.3 12.7 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DUF1244 PF06844.11 EAK87417.1 - 1.8 8.8 3.8 5.7 7.2 3.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) Zn_ribbon_17 PF17120.5 EAK87417.1 - 4.5 7.0 9.4 19 5.0 8.6 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type GCP_C_terminal PF04130.13 EAK87418.1 - 1.6e-13 50.8 5.9 1.6e-13 50.8 5.9 2.3 2 1 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EAK87419.1 - 1.5e-16 60.9 2.8 9.3e-16 58.3 2.8 2.1 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF5582 PF17819.1 EAK87419.1 - 0.017 15.6 0.2 0.03 14.8 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5582) Meth_synt_2 PF01717.18 EAK87419.1 - 0.088 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Cobalamin-independent synthase, Catalytic domain GlutR_N PF05201.15 EAK87422.1 - 0.04 13.7 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain Peptidase_M16_C PF05193.21 EAK87423.1 - 2.1e-06 27.9 0.7 0.00082 19.4 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain NPM1-C PF16276.5 EAK87423.1 - 0.084 12.9 0.3 0.46 10.5 0.0 2.4 2 0 0 2 2 2 0 Nucleophosmin C-terminal domain TPR_2 PF07719.17 EAK87426.1 - 2.8e-07 30.1 2.6 0.014 15.5 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EAK87426.1 - 8.1e-07 28.8 0.6 0.056 13.7 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EAK87426.1 - 1.8e-05 25.2 0.0 0.2 12.2 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EAK87426.1 - 2.5e-05 24.7 0.1 0.0071 17.1 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EAK87426.1 - 3.8e-05 23.7 0.9 0.55 10.4 0.1 3.5 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EAK87426.1 - 8.4e-05 22.2 0.0 0.00051 19.7 0.0 2.3 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.28 EAK87426.1 - 0.00044 19.9 0.2 0.035 13.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EAK87426.1 - 0.00045 20.1 0.2 0.31 11.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EAK87426.1 - 0.00047 20.4 0.0 1.3 9.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EAK87426.1 - 0.0023 18.1 0.1 2.9 8.1 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK87426.1 - 0.039 14.2 1.2 0.26 11.5 1.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EAK87426.1 - 0.087 13.5 0.0 3.9 8.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3791 PF12668.7 EAK87426.1 - 0.34 11.0 4.4 0.15 12.1 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3791) Sel1 PF08238.12 EAK87430.1 - 4.4e-11 43.1 12.3 0.0039 17.8 0.6 5.0 5 0 0 5 5 5 3 Sel1 repeat Peptidase_C14 PF00656.22 EAK87431.1 - 4.2e-30 105.5 0.0 2.4e-29 103.0 0.0 2.1 2 0 0 2 2 2 1 Caspase domain DUF155 PF02582.14 EAK87432.1 - 2.1e-49 168.0 0.1 3.4e-49 167.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CRAL_TRIO PF00650.20 EAK87433.1 - 3.1e-23 82.2 0.1 9.7e-23 80.6 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 EAK87433.1 - 0.0077 16.7 0.0 0.0077 16.7 0.0 4.2 4 1 0 4 4 4 1 Golgi-dynamics membrane-trafficking IFT81_CH PF18383.1 EAK87433.1 - 0.059 13.6 4.8 2.4 8.4 0.0 3.7 3 0 0 3 3 3 0 Intraflagellar transport 81 calponin homology domain MFS_1 PF07690.16 EAK87435.1 - 4.6e-33 114.6 54.1 2.1e-26 92.7 29.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EAK87435.1 - 7.7e-05 21.7 0.6 7.7e-05 21.7 0.6 3.5 3 1 0 3 3 3 2 MFS_1 like family PC_rep PF01851.22 EAK87436.1 - 1.2e-29 101.2 16.9 0.0012 19.2 0.4 9.9 9 0 0 9 9 9 7 Proteasome/cyclosome repeat RPN2_C PF18004.1 EAK87436.1 - 1.4e-28 99.8 9.9 1.4e-28 99.8 9.9 3.3 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 EAK87436.1 - 1.4e-19 70.3 0.0 5.1e-13 49.2 0.0 6.0 4 1 3 7 7 7 3 HEAT repeats HEAT PF02985.22 EAK87436.1 - 2e-05 24.5 0.1 0.54 10.7 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EAK87436.1 - 0.00026 21.4 0.1 0.049 14.1 0.0 4.3 6 0 0 6 6 6 1 HEAT-like repeat TPR_12 PF13424.6 EAK87436.1 - 0.05 13.9 0.1 0.41 11.0 0.1 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EAK87436.1 - 0.17 11.8 1.5 1.8 8.5 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK87436.1 - 0.27 11.5 4.2 1.1 9.5 0.1 3.7 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EAK87436.1 - 0.46 10.7 3.6 1.5 9.1 0.5 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Myosin_tail_1 PF01576.19 EAK87437.1 - 0.01 13.7 8.8 0.012 13.5 8.8 1.0 1 0 0 1 1 1 0 Myosin tail DUF836 PF05768.14 EAK87437.1 - 0.016 15.6 4.0 0.016 15.6 4.0 1.8 1 1 1 2 2 2 0 Glutaredoxin-like domain (DUF836) CCDC92 PF14916.6 EAK87437.1 - 0.069 12.9 0.4 0.069 12.9 0.4 2.6 3 0 0 3 3 3 0 Coiled-coil domain of unknown function Jnk-SapK_ap_N PF09744.9 EAK87437.1 - 0.16 12.2 14.4 1.2 9.3 14.4 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Nmad5 PF18757.1 EAK87437.1 - 0.92 9.7 8.6 1.2 9.3 8.6 1.2 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 YlqD PF11068.8 EAK87437.1 - 1 9.7 9.5 0.5 10.7 6.3 1.8 1 1 1 2 2 2 0 YlqD protein DUF745 PF05335.13 EAK87437.1 - 1.1 9.0 4.5 1.5 8.6 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) bZIP_1 PF00170.21 EAK87437.1 - 1.3 9.1 17.5 1.6 8.9 0.9 3.3 3 0 0 3 3 3 0 bZIP transcription factor CENP-H PF05837.12 EAK87437.1 - 5.8 7.4 11.7 28 5.2 8.1 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Exonuc_VII_L PF02601.15 EAK87437.1 - 6.6 6.2 7.7 7.6 6.0 7.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lipoprotein_2 PF00921.17 EAK87437.1 - 6.8 6.2 8.2 3.4 7.1 5.4 1.9 1 1 2 3 3 3 0 Borrelia lipoprotein Fib_alpha PF08702.10 EAK87437.1 - 7.2 6.8 14.7 8.8 6.5 14.1 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Acetyltransf_1 PF00583.25 EAK87438.1 - 6.6e-17 61.8 0.1 7.8e-17 61.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EAK87438.1 - 5e-12 45.9 0.0 6.7e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EAK87438.1 - 6.7e-09 36.1 0.1 9.1e-09 35.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EAK87438.1 - 4.9e-05 23.2 0.0 8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EAK87438.1 - 0.00021 21.3 0.0 0.00045 20.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EAK87438.1 - 0.00046 20.9 0.0 0.00058 20.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EAK87438.1 - 0.011 15.9 0.1 0.012 15.7 0.1 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EAK87438.1 - 0.015 14.8 0.1 0.024 14.1 0.1 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_9 PF13527.7 EAK87438.1 - 0.03 14.4 0.0 0.089 12.9 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Clenterotox PF03505.14 EAK87438.1 - 0.031 13.9 0.0 0.068 12.8 0.0 1.6 2 0 0 2 2 2 0 Clostridium enterotoxin CBS PF00571.28 EAK87438.1 - 0.11 12.9 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 CBS domain CLP1_P PF16575.5 EAK87439.1 - 0.038 13.8 0.3 4.9 6.9 0.0 3.0 3 1 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Ribonuc_red_2_N PF08471.10 EAK87439.1 - 0.15 12.3 0.0 0.42 10.8 0.0 1.7 1 0 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase Vps51 PF08700.11 EAK87440.1 - 2.2e-07 30.8 1.4 2.2e-07 30.8 1.4 3.6 3 0 0 3 3 3 1 Vps51/Vps67 Cwf_Cwc_15 PF04889.12 EAK87441.1 - 0.0044 16.8 5.6 0.0044 16.8 5.6 2.5 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein TBCA PF02970.16 EAK87441.1 - 0.079 13.3 4.2 0.18 12.2 4.2 1.6 1 0 0 1 1 1 0 Tubulin binding cofactor A TFIIF_alpha PF05793.12 EAK87441.1 - 1.4 7.4 40.5 0.24 9.9 17.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PBP1_TM PF14812.6 EAK87441.1 - 7.2 7.1 27.3 0.51 10.7 8.9 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PPI_Ypi1 PF07491.11 EAK87442.1 - 2.4e-15 56.1 30.3 4.6e-14 52.0 29.5 2.9 1 1 0 1 1 1 1 Protein phosphatase inhibitor AF-4 PF05110.13 EAK87442.1 - 0.0011 17.1 21.3 0.0013 16.9 21.3 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein IBB PF01749.20 EAK87442.1 - 0.42 11.1 5.7 0.34 11.4 0.5 2.2 2 0 0 2 2 2 0 Importin beta binding domain FAM176 PF14851.6 EAK87442.1 - 4.4 7.0 11.6 4.6 6.9 0.2 2.1 1 1 0 2 2 2 0 FAM176 family RNase_PH PF01138.21 EAK87443.1 - 3.4e-23 82.6 0.2 4.9e-23 82.1 0.2 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EAK87443.1 - 0.079 13.0 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 IMS PF00817.20 EAK87444.1 - 1.4e-30 106.3 0.0 1.8e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 impB/mucB/samB family DUF761 PF05553.11 EAK87444.1 - 0.14 11.7 2.5 0.27 10.8 0.1 2.6 2 0 0 2 2 2 0 Cotton fibre expressed protein Macoilin PF09726.9 EAK87445.1 - 0.0028 16.3 16.5 0.0043 15.7 16.5 1.3 1 0 0 1 1 1 1 Macoilin family Atrophin-1 PF03154.15 EAK87445.1 - 0.19 10.0 19.7 0.25 9.6 19.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family PI3K_1B_p101 PF10486.9 EAK87445.1 - 0.32 8.7 13.9 0.45 8.2 13.9 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 EAK87445.1 - 5.1 5.3 13.6 8.8 4.5 13.6 1.4 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EAK87445.1 - 8.5 4.4 22.9 15 3.7 22.9 1.3 1 0 0 1 1 1 0 Nop14-like family LAP1C PF05609.12 EAK87445.1 - 8.5 5.3 16.5 1.9 7.5 12.3 1.8 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Thymidylat_synt PF00303.19 EAK87446.1 - 6.1e-108 360.0 0.0 8e-108 359.6 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 EAK87446.1 - 4.9e-34 117.3 0.0 1.4e-33 115.9 0.0 1.7 2 0 0 2 2 2 1 Dihydrofolate reductase OTU PF02338.19 EAK87447.1 - 2.8e-18 66.6 0.4 3.3e-18 66.4 0.4 1.0 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EAK87447.1 - 6.7e-07 29.0 1.4 7.7e-07 28.8 1.4 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain Peptidase_C78 PF07910.13 EAK87447.1 - 0.035 13.6 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase family C78 DUF1016_N PF17761.1 EAK87447.1 - 0.044 13.9 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 DUF1016 N-terminal domain Adaptin_N PF01602.20 EAK87448.1 - 2.3e-116 389.4 17.3 3.2e-116 389.0 17.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EAK87448.1 - 6.7e-51 172.5 1.1 6.7e-51 172.5 1.1 3.5 2 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EAK87448.1 - 6.5e-13 48.9 0.2 2.3e-07 31.1 0.0 5.1 4 2 1 5 5 5 3 HEAT repeats HEAT PF02985.22 EAK87448.1 - 6.2e-12 44.7 2.2 0.00061 19.8 0.0 6.7 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 EAK87448.1 - 0.00019 21.8 0.2 0.25 11.9 0.0 4.5 2 2 2 4 4 4 1 HEAT-like repeat Condensin2nSMC PF12422.8 EAK87448.1 - 0.089 13.0 3.0 2.5 8.3 0.1 3.4 2 1 1 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit Peptidase_M14 PF00246.24 EAK87449.1 - 6.9e-16 58.9 0.1 1.8e-15 57.6 0.1 1.6 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EAK87449.1 - 9.6e-09 34.7 0.0 1.8e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 EAK87449.1 - 0.0015 18.0 0.0 0.0015 18.0 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2817) zf-B_box PF00643.24 EAK87450.1 - 1.2e-08 35.0 23.9 1.8e-05 24.8 5.4 3.0 3 0 0 3 3 3 2 B-box zinc finger DUF1043 PF06295.12 EAK87450.1 - 0.037 14.0 0.3 0.037 14.0 0.3 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1043) GDI PF00996.18 EAK87451.1 - 3.9e-202 671.5 0.1 4.5e-202 671.3 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Arm_vescicular PF18770.1 EAK87451.1 - 0.015 15.2 0.1 0.04 13.8 0.1 1.7 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor Avidin PF01382.17 EAK87451.1 - 0.048 14.1 0.1 0.98 9.9 0.0 2.6 3 0 0 3 3 3 0 Avidin family NAD_binding_8 PF13450.6 EAK87451.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GN3L_Grn1 PF08701.11 EAK87452.1 - 5.2e-17 61.7 18.7 1.2e-16 60.6 18.7 1.7 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EAK87452.1 - 3.3e-15 56.1 0.6 1.6e-13 50.7 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAK87452.1 - 2.5e-09 36.8 0.5 2.4e-06 27.1 0.1 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EAK87452.1 - 1.7e-06 28.0 0.3 0.00025 21.0 0.1 2.9 1 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EAK87452.1 - 0.021 14.4 0.4 2.7 7.5 0.0 3.1 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EAK87452.1 - 0.18 11.8 0.1 0.18 11.8 0.1 3.3 2 2 0 2 2 2 0 Dynamin family AAA_18 PF13238.6 EAK87452.1 - 0.22 12.1 2.7 0.53 10.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 EAK87452.1 - 0.34 9.8 0.0 0.34 9.8 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EAK87452.1 - 0.84 10.2 0.0 0.84 10.2 0.0 2.6 3 1 0 3 3 3 0 ABC transporter Ribosomal_S5 PF00333.20 EAK87453.1 - 2.3e-28 97.9 0.8 4.6e-28 97.0 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EAK87453.1 - 3.8e-21 74.3 0.0 6.6e-21 73.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain W_rich_C PF07483.11 EAK87454.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain Transformer PF06495.11 EAK87456.1 - 0.0048 17.0 22.6 0.0048 17.0 22.6 3.3 2 1 0 3 3 3 1 Fruit fly transformer protein Serglycin PF04360.12 EAK87456.1 - 3.3 7.7 8.3 0.27 11.2 1.4 2.8 3 0 0 3 3 3 0 Serglycin HbrB PF08539.11 EAK87457.1 - 2.1 8.3 9.7 5.1 7.1 7.9 2.6 2 1 0 2 2 2 0 HbrB-like Metallophos PF00149.28 EAK87460.1 - 7.1e-15 56.0 0.4 6.4e-14 52.9 0.4 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Aa_trans PF01490.18 EAK87461.1 - 2.6e-59 201.0 38.8 3.2e-59 200.7 38.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EAK87461.1 - 0.00034 19.8 30.3 0.0017 17.5 30.3 2.0 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family DUF4233 PF14017.6 EAK87461.1 - 8.6 6.8 18.3 5.3 7.4 0.6 4.2 4 1 1 5 5 5 0 Protein of unknown function (DUF4233) DUF3973 PF13119.6 EAK87462.1 - 0.1 12.7 0.1 11 6.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3973) APC_r PF05923.12 EAK87463.1 - 0.34 10.7 2.2 1.1 9.1 2.2 1.9 1 0 0 1 1 1 0 APC repeat TFIIIC_sub6 PF10419.9 EAK87464.1 - 0.0053 16.6 0.5 0.0084 16.0 0.5 1.3 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain DUF543 PF04418.12 EAK87465.1 - 2.5 8.2 5.3 5.6 7.0 5.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF543) YL1 PF05764.13 EAK87466.1 - 1.8e-31 110.1 29.4 1.8e-31 110.1 29.4 2.2 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 EAK87466.1 - 2.1e-11 43.4 0.6 2.7e-10 39.8 0.2 2.4 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain ThiF PF00899.21 EAK87468.1 - 0.0021 17.5 0.0 0.0038 16.6 0.0 1.4 1 0 0 1 1 1 1 ThiF family RNA_pol_Rpb2_6 PF00562.28 EAK87469.1 - 3e-124 415.0 0.0 4.5e-124 414.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EAK87469.1 - 5.8e-47 159.8 0.1 1e-46 159.0 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EAK87469.1 - 1.3e-32 112.1 0.1 3.4e-32 110.7 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EAK87469.1 - 1.5e-23 82.9 0.1 3.3e-23 81.7 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EAK87469.1 - 2.2e-20 73.1 0.2 7.5e-20 71.4 0.2 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EAK87469.1 - 1.6e-19 69.9 0.0 3.2e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EAK87469.1 - 2e-09 37.8 0.3 1.3e-08 35.3 0.3 2.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 PAN_1 PF00024.26 EAK87470.1 - 6.1e-05 22.9 7.2 0.0014 18.6 2.6 3.0 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.6 EAK87470.1 - 0.00086 19.2 0.3 0.00086 19.2 0.3 3.5 3 1 0 3 3 3 2 PAN domain TSP_1 PF00090.19 EAK87470.1 - 0.0021 18.2 2.3 0.0021 18.2 2.3 4.6 3 1 1 4 4 4 3 Thrombospondin type 1 domain Collagen_bind PF05737.12 EAK87470.1 - 0.23 11.6 2.3 0.42 10.8 2.3 1.3 1 0 0 1 1 1 0 Collagen binding domain DEAD PF00270.29 EAK87472.1 - 2.7e-36 125.0 0.0 1.2e-35 122.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87472.1 - 5.1e-26 91.2 0.0 2.7e-25 88.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EAK87472.1 - 0.0013 19.0 0.8 0.011 16.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain ERCC3_RAD25_C PF16203.5 EAK87472.1 - 0.017 14.4 0.1 0.017 14.4 0.1 2.6 3 0 0 3 3 3 0 ERCC3/RAD25/XPB C-terminal helicase Porin_OmpL1 PF11389.8 EAK87472.1 - 0.064 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Leptospira porin protein OmpL1 EF-hand_6 PF13405.6 EAK87473.1 - 0.14 12.2 0.0 0.52 10.4 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain DUF2318 PF10080.9 EAK87474.1 - 0.0012 19.0 0.5 0.0023 18.0 0.5 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) EXOSC1 PF10447.9 EAK87474.1 - 0.05 14.2 0.0 0.11 13.1 0.0 1.9 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 Zn_Tnp_IS91 PF14319.6 EAK87474.1 - 0.14 12.2 1.6 0.23 11.5 0.7 1.8 2 0 0 2 2 2 0 Transposase zinc-binding domain MadL PF03817.13 EAK87475.1 - 0.017 15.1 0.6 0.074 13.1 0.0 2.1 2 0 0 2 2 2 0 Malonate transporter MadL subunit FKS1_dom1 PF14288.6 EAK87475.1 - 0.097 13.0 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF3067 PF11267.8 EAK87475.1 - 0.19 12.3 0.0 0.35 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3067) MOZ_SAS PF01853.18 EAK87476.1 - 4.9e-67 225.1 0.7 7.8e-64 214.6 0.7 2.3 2 0 0 2 2 2 2 MOZ/SAS family zf-MYST PF17772.1 EAK87476.1 - 1.3e-21 75.9 1.9 2.9e-21 74.8 1.9 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EAK87476.1 - 6.5e-10 38.7 0.9 1.4e-09 37.7 0.9 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EAK87476.1 - 0.00018 21.9 0.0 0.00044 20.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EAK87476.1 - 0.055 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EAK87476.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Fumble PF03630.14 EAK87477.1 - 1.2e-25 90.4 0.9 1.4e-25 90.2 0.9 1.2 1 0 0 1 1 1 1 Fumble HIPIP PF01355.17 EAK87478.1 - 0.42 11.0 1.4 0.66 10.4 0.3 1.8 2 0 0 2 2 2 0 High potential iron-sulfur protein STATa_Ig PF18214.1 EAK87479.1 - 0.0043 17.0 0.4 0.0043 17.0 0.4 2.0 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain Metallophos PF00149.28 EAK87480.1 - 8.1e-13 49.3 0.2 1.4e-12 48.6 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase UPF0239 PF06783.11 EAK87480.1 - 0.01 16.0 0.3 0.018 15.2 0.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) RNA_pol_A_bac PF01000.26 EAK87481.1 - 4.8e-26 91.3 0.1 9.6e-26 90.4 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EAK87481.1 - 1.7e-21 75.4 0.0 2.5e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 EAK87481.1 - 0.0026 17.9 0.9 0.0064 16.6 0.9 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EAK87481.1 - 0.017 15.7 1.6 0.043 14.4 1.6 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 EAK87481.1 - 0.024 14.7 1.4 0.024 14.7 1.4 2.0 3 0 0 3 3 3 0 4Fe-4S dicluster domain tRNA-synt_2 PF00152.20 EAK87485.1 - 3.2e-84 282.7 0.0 6.7e-84 281.6 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EAK87485.1 - 8.7e-06 25.6 0.1 2.2e-05 24.4 0.1 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EAK87485.1 - 0.0014 18.1 0.0 0.013 15.0 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) DAO PF01266.24 EAK87486.1 - 4.7e-08 33.0 0.0 6.5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 EAK87486.1 - 0.00023 21.4 0.0 0.00089 19.5 0.0 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EAK87486.1 - 0.012 16.0 0.0 0.066 13.6 0.0 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain BLOC1_2 PF10046.9 EAK87486.1 - 0.057 13.7 1.1 0.19 12.1 0.0 2.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spermine_synth PF01564.17 EAK87486.1 - 0.086 12.2 0.6 13 5.1 0.1 2.5 2 0 0 2 2 2 0 Spermine/spermidine synthase domain Mqo PF06039.15 EAK87486.1 - 0.19 10.2 0.9 0.55 8.7 0.1 2.0 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) NAD_binding_8 PF13450.6 EAK87486.1 - 0.2 11.9 0.0 0.41 10.9 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain IPP-2 PF04979.14 EAK87487.1 - 1.7e-13 51.5 8.9 1.7e-13 51.5 8.9 2.0 1 1 1 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) AF-4 PF05110.13 EAK87487.1 - 0.025 12.7 19.5 0.027 12.6 19.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ribosomal_L6 PF00347.23 EAK87488.1 - 6e-28 97.3 2.5 3e-16 59.8 1.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Beta-Casp PF10996.8 EAK87490.1 - 4.5e-29 101.0 0.0 9.5e-29 99.9 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EAK87490.1 - 1.6e-16 60.3 0.0 3.3e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EAK87490.1 - 2.6e-16 59.3 0.0 5.6e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EAK87490.1 - 1.6e-13 51.1 0.0 4.8e-13 49.6 0.0 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily CPSF73-100_C PF11718.8 EAK87490.1 - 7.5e-05 22.4 0.4 0.00014 21.5 0.4 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_3 PF13483.6 EAK87490.1 - 0.00083 19.3 0.0 0.0029 17.5 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EAK87490.1 - 0.0023 17.5 0.1 0.015 14.8 0.1 2.3 2 1 0 2 2 2 1 Beta-lactamase superfamily domain DisA-linker PF10635.9 EAK87490.1 - 0.027 14.2 2.3 0.31 10.8 0.7 2.6 2 0 0 2 2 2 0 DisA bacterial checkpoint controller linker region HP1451_C PF18472.1 EAK87490.1 - 0.045 13.7 0.8 0.12 12.3 0.8 1.7 1 0 0 1 1 1 0 HP1451 C-terminal domain MRG PF05712.13 EAK87491.1 - 1.5e-19 70.1 4.8 3.7e-19 68.8 2.9 2.2 2 0 0 2 2 2 1 MRG DUF1360 PF07098.11 EAK87491.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) Hist_deacetyl PF00850.19 EAK87492.1 - 4.5e-63 213.6 0.0 8.4e-63 212.7 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Ank_2 PF12796.7 EAK87492.1 - 1e-13 51.7 0.1 9.4e-09 35.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK87492.1 - 4.7e-13 49.4 0.9 0.0002 21.9 0.1 3.8 2 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAK87492.1 - 1.6e-11 43.4 1.0 0.00033 20.9 0.1 4.2 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EAK87492.1 - 1.2e-10 41.4 1.6 2e-05 24.8 0.3 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EAK87492.1 - 7.7e-10 38.8 0.3 3.6e-05 24.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) AhpC-TSA PF00578.21 EAK87492.1 - 0.023 14.6 0.2 0.045 13.7 0.2 1.4 1 0 0 1 1 1 0 AhpC/TSA family SAS-6_N PF16531.5 EAK87493.1 - 2e-17 63.5 0.0 2.5e-16 60.0 0.0 3.0 2 1 0 2 2 2 1 Centriolar protein SAS N-terminal SHE3 PF17078.5 EAK87493.1 - 3.4e-06 26.9 47.5 4.7e-05 23.2 4.4 4.0 1 1 3 4 4 4 2 SWI5-dependent HO expression protein 3 EzrA PF06160.12 EAK87493.1 - 0.0052 15.0 49.2 0.017 13.3 26.0 3.2 1 1 2 3 3 3 2 Septation ring formation regulator, EzrA DUF3450 PF11932.8 EAK87493.1 - 0.17 11.2 36.3 0.015 14.6 13.5 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) Tektin PF03148.14 EAK87493.1 - 0.24 10.1 37.0 0.02 13.6 8.1 3.6 1 1 2 3 3 3 0 Tektin family Flagellin_C PF00700.21 EAK87493.1 - 0.41 11.0 7.9 9 6.7 0.2 4.0 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region GAS PF13851.6 EAK87493.1 - 1.2 8.5 46.1 0.19 11.1 14.0 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EAK87493.1 - 1.2 7.9 45.7 0.28 10.0 12.2 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein UPF0242 PF06785.11 EAK87493.1 - 1.4 9.0 50.8 0.11 12.5 30.4 3.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 EAK87493.1 - 1.4 8.9 44.1 1.4 9.0 8.2 4.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TACC_C PF05010.14 EAK87493.1 - 2.1 8.1 40.7 5.1 6.8 23.8 3.2 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ADIP PF11559.8 EAK87493.1 - 4.3 7.4 44.2 1.4 9.0 9.9 4.7 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding Rab5-bind PF09311.11 EAK87493.1 - 4.4 6.6 40.9 0.15 11.5 11.2 3.5 1 1 2 3 3 3 0 Rabaptin-like protein MAD PF05557.13 EAK87493.1 - 6.5 5.0 46.5 2.3 6.4 28.5 2.4 1 1 1 2 2 2 0 Mitotic checkpoint protein Lebercilin PF15619.6 EAK87493.1 - 9.6 5.8 48.1 0.16 11.6 16.7 3.7 2 1 2 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease PseudoU_synth_1 PF01416.20 EAK87494.1 - 5.1e-15 55.9 0.0 1.6e-12 47.8 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase Lipase_GDSL PF00657.22 EAK87495.1 - 0.002 18.1 4.3 0.025 14.5 4.3 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF2785 PF10978.8 EAK87495.1 - 0.87 9.3 4.8 3.9 7.2 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2785) CAF-1_p150 PF11600.8 EAK87495.1 - 1.8 8.3 70.6 0.36 10.5 46.5 3.0 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal ERG2_Sigma1R PF04622.12 EAK87495.1 - 6.1 6.1 10.5 5 6.4 0.4 3.1 2 1 1 3 3 3 0 ERG2 and Sigma1 receptor like protein Bud13 PF09736.9 EAK87495.1 - 7.9 6.9 41.7 1.2 9.5 22.2 2.5 3 0 0 3 3 3 0 Pre-mRNA-splicing factor of RES complex DUF4834 PF16118.5 EAK87496.1 - 0.016 16.1 0.3 0.016 16.1 0.3 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) DUF4692 PF15763.5 EAK87496.1 - 0.16 12.5 0.0 0.16 12.5 0.0 2.2 2 1 1 3 3 3 0 Regulator of human erythroid cell expansion (RHEX) OAD_gamma PF04277.13 EAK87496.1 - 0.29 11.7 0.0 0.29 11.7 0.0 2.7 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Tetraspanin PF00335.20 EAK87496.1 - 1.8 8.2 22.0 10 5.7 18.5 2.5 1 1 0 1 1 1 0 Tetraspanin family CRCB PF02537.15 EAK87496.1 - 3.1 8.2 9.1 15 6.0 9.1 2.3 1 1 0 1 1 1 0 CrcB-like protein, Camphor Resistance (CrcB) TSP_1 PF00090.19 EAK87497.1 - 0.065 13.5 0.1 0.065 13.5 0.1 4.9 4 1 2 6 6 6 0 Thrombospondin type 1 domain Hydrolase_4 PF12146.8 EAK87499.1 - 8.8e-19 67.7 0.0 1.5e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK87499.1 - 3.4e-16 59.7 0.1 8.6e-14 51.8 0.1 2.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EAK87499.1 - 2.4e-09 38.1 0.0 3e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EAK87499.1 - 2.6e-06 27.2 0.0 0.00069 19.2 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family LIDHydrolase PF10230.9 EAK87499.1 - 0.0072 15.9 0.0 0.055 13.0 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase UPF0227 PF05728.12 EAK87499.1 - 0.0087 16.0 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) FAM91_C PF14648.6 EAK87499.1 - 0.034 13.0 0.1 0.049 12.5 0.1 1.2 1 0 0 1 1 1 0 FAM91 C-terminus ITAM PF02189.15 EAK87500.1 - 0.039 14.4 0.8 0.085 13.3 0.1 2.0 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif Proteasom_PSMB PF10508.9 EAK87501.1 - 2.8e-26 92.1 7.9 1.2e-25 90.0 7.9 2.0 1 1 0 1 1 1 1 Proteasome non-ATPase 26S subunit Cnd1 PF12717.7 EAK87501.1 - 0.0049 16.9 7.6 0.0065 16.5 0.3 3.3 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Mcl1_mid PF12341.8 EAK87502.1 - 5.2e-41 140.9 0.0 1.2e-40 139.8 0.0 1.6 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region PPR_2 PF13041.6 EAK87504.1 - 0.065 13.4 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 PPR repeat family RNase_E_G PF10150.9 EAK87504.1 - 1.8 7.9 6.4 0.21 11.0 0.1 2.3 3 0 0 3 3 3 0 Ribonuclease E/G family DivIC PF04977.15 EAK87505.1 - 0.015 15.0 6.9 0.54 10.1 0.2 3.3 3 0 0 3 3 3 0 Septum formation initiator QueC PF06508.13 EAK87505.1 - 0.054 13.0 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC DUF4407 PF14362.6 EAK87505.1 - 0.1 11.9 2.0 0.15 11.4 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TBP PF00352.21 EAK87506.1 - 2.8e-18 65.7 0.6 1.1e-10 41.3 0.1 2.9 2 1 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) vATP-synt_E PF01991.18 EAK87507.1 - 9.4e-58 194.9 8.8 1.2e-57 194.6 8.8 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Par3_HAL_N_term PF12053.8 EAK87507.1 - 0.027 14.7 0.2 0.027 14.7 0.2 2.1 2 1 0 2 2 2 0 N-terminal of Par3 and HAL proteins FNIP_M PF14637.6 EAK87507.1 - 0.03 14.3 0.6 0.042 13.9 0.6 1.3 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain NAD_binding_5 PF07994.12 EAK87507.1 - 0.31 10.4 4.5 0.17 11.2 1.6 1.8 1 1 1 2 2 2 0 Myo-inositol-1-phosphate synthase SATase_N PF06426.14 EAK87507.1 - 0.53 10.7 3.9 0.61 10.5 1.5 2.2 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal Folliculin PF11704.8 EAK87507.1 - 1.4 8.8 4.6 2.3 8.1 4.6 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Tropomyosin_1 PF12718.7 EAK87508.1 - 0.0052 16.9 10.5 0.0052 16.9 10.5 5.5 5 1 1 6 6 6 1 Tropomyosin like Lipoprotein_2 PF00921.17 EAK87508.1 - 0.011 15.3 0.1 0.011 15.3 0.1 4.8 4 1 1 5 5 5 0 Borrelia lipoprotein Ribosomal_L7Ae PF01248.26 EAK87509.1 - 1.2e-20 73.0 0.8 2.4e-20 72.0 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L5e PF17144.4 EAK87510.1 - 3.2e-83 277.6 0.1 3.2e-83 277.6 0.1 2.1 3 0 0 3 3 3 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EAK87510.1 - 9.3e-31 106.6 8.8 9.3e-31 106.6 8.8 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF4208 PF13907.6 EAK87510.1 - 0.05 14.1 0.5 0.11 12.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) DnaJ PF00226.31 EAK87511.1 - 7.9e-16 57.9 0.9 7.9e-16 57.9 0.9 2.7 2 0 0 2 2 2 1 DnaJ domain RPT PF13446.6 EAK87511.1 - 0.005 16.7 0.1 0.049 13.6 0.0 2.6 2 1 1 3 3 3 1 A repeated domain in UCH-protein DUF2208 PF09973.9 EAK87511.1 - 0.74 9.4 3.0 1.3 8.6 3.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) EF-hand_8 PF13833.6 EAK87512.1 - 5.7e-13 48.5 1.7 6.5e-08 32.3 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK87512.1 - 1.3e-07 31.0 1.4 0.078 12.9 0.1 4.1 4 1 1 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 EAK87512.1 - 1.5e-07 30.4 4.1 0.014 14.9 0.0 4.0 4 1 1 5 5 5 2 EF hand EF-hand_7 PF13499.6 EAK87512.1 - 2.5e-07 31.0 1.9 0.0094 16.4 0.0 3.2 1 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EAK87512.1 - 0.011 15.2 5.7 1.5 8.5 0.4 4.0 3 1 1 4 4 4 0 EF hand EF-hand_9 PF14658.6 EAK87512.1 - 0.013 15.8 0.0 0.031 14.6 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain DUF5475 PF17569.2 EAK87512.1 - 0.13 12.6 0.0 0.43 10.9 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5475) RPN1_RPN2_N PF17781.1 EAK87513.1 - 2.6e-75 253.7 9.2 6.1e-75 252.5 9.2 1.6 1 1 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EAK87513.1 - 1e-25 89.5 0.0 2e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EAK87513.1 - 8.7e-16 57.5 12.8 3.4e-05 24.1 0.1 8.0 8 0 0 8 8 8 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EAK87513.1 - 6.1e-07 29.8 0.1 0.043 14.2 0.0 3.9 2 1 1 3 3 3 2 HEAT repeats Cnd1 PF12717.7 EAK87513.1 - 0.038 14.0 0.0 0.23 11.5 0.0 2.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EAK87513.1 - 0.089 13.1 0.0 0.68 10.4 0.0 2.7 1 0 0 1 1 1 0 HEAT repeat Ago_N_1 PF18351.1 EAK87513.1 - 0.2 12.1 0.4 11 6.5 0.0 2.6 2 0 0 2 2 2 0 Fungal Argonaute N-terminal domain Abhydrolase_1 PF00561.20 EAK87514.1 - 5.3e-15 55.8 0.0 9.4e-15 54.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EAK87514.1 - 1.4e-13 50.7 0.0 3e-13 49.6 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EAK87514.1 - 8.5e-09 36.3 0.0 1.1e-08 36.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EAK87514.1 - 0.00013 21.7 0.0 0.001 18.8 0.0 2.0 2 0 0 2 2 2 1 Putative esterase Peptidase_S9 PF00326.21 EAK87514.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.5 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF1100 PF06500.11 EAK87514.1 - 0.11 11.3 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) RFC1 PF08519.12 EAK87515.1 - 1.6e-36 125.9 0.5 5.2e-36 124.2 0.2 2.0 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EAK87515.1 - 7.7e-15 55.0 0.0 2.7e-14 53.3 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DNA_pol3_delta PF06144.13 EAK87515.1 - 2.6e-09 37.1 0.1 2.6e-09 37.1 0.1 2.2 2 0 0 2 2 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EAK87515.1 - 2.3e-08 34.5 0.0 8.9e-08 32.6 0.0 2.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PTCB-BRCT PF12738.7 EAK87515.1 - 0.0001 22.1 0.2 0.00034 20.5 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain Rad17 PF03215.15 EAK87515.1 - 0.00017 21.6 1.3 0.0048 16.8 0.3 3.2 2 1 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EAK87515.1 - 0.0084 15.9 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EAK87515.1 - 0.012 16.0 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EAK87515.1 - 0.017 15.7 0.0 0.017 15.7 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_5 PF07728.14 EAK87515.1 - 0.017 15.1 0.0 0.066 13.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EAK87515.1 - 0.023 14.8 0.0 0.086 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EAK87515.1 - 0.036 14.3 0.0 0.17 12.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 EAK87515.1 - 0.051 13.9 0.0 0.28 11.5 0.0 2.3 2 0 0 2 2 1 0 AAA C-terminal domain NACHT PF05729.12 EAK87515.1 - 0.1 12.5 0.0 15 5.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain Lig_C PF18330.1 EAK87515.1 - 0.38 10.8 2.0 5 7.2 0.5 3.1 3 0 0 3 3 3 0 Ligase Pab1020 C-terminal region Ribosomal_L23 PF00276.20 EAK87516.1 - 7.7e-17 61.4 5.7 7.7e-17 61.4 5.7 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EAK87516.1 - 1.6e-14 53.8 10.9 3.1e-14 52.9 10.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Peptidase_C3 PF00548.20 EAK87520.1 - 0.16 11.9 0.4 0.24 11.3 0.4 1.2 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) zf-DNL PF05180.12 EAK87521.1 - 1.1e-21 76.5 4.5 2.2e-21 75.6 4.5 1.4 1 0 0 1 1 1 1 DNL zinc finger TRAM_LAG1_CLN8 PF03798.16 EAK87524.1 - 8.4e-28 97.5 17.2 8.4e-28 97.5 17.2 1.5 2 0 0 2 2 2 1 TLC domain LSM PF01423.22 EAK87525.1 - 6.8e-09 35.3 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EAK87525.1 - 0.01 16.0 0.1 0.039 14.1 0.0 2.0 2 0 0 2 2 2 0 Ataxin 2 SM domain Ank_2 PF12796.7 EAK87526.1 - 5.5e-39 132.6 9.2 5.5e-10 39.7 0.0 3.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK87526.1 - 4.5e-21 74.9 7.5 0.00017 22.0 0.0 5.8 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EAK87526.1 - 9.5e-20 70.1 8.9 1.7e-05 25.1 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 EAK87526.1 - 3.5e-17 60.7 8.9 0.0036 17.7 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EAK87526.1 - 4e-17 62.0 5.4 0.00084 19.6 0.2 6.3 3 1 4 7 7 7 4 Ankyrin repeats (many copies) BAH PF01426.18 EAK87526.1 - 0.0033 17.3 0.0 0.0043 16.9 0.0 1.4 1 0 0 1 1 1 1 BAH domain Orf78 PF06024.12 EAK87526.1 - 0.082 13.2 8.3 0.48 10.7 0.3 2.8 3 0 0 3 3 3 0 Orf78 (ac78) DcuA_DcuB PF03605.14 EAK87526.1 - 0.084 11.8 0.1 0.51 9.2 0.1 1.9 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter DUF2615 PF11027.8 EAK87526.1 - 0.37 11.0 2.0 0.43 10.7 0.1 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) SARAF PF06682.12 EAK87526.1 - 1.2 8.7 3.2 0.33 10.6 0.1 1.5 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis ABC2_membrane_3 PF12698.7 EAK87526.1 - 7.9 5.5 8.3 12 4.8 8.3 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Ribosomal_S17e PF00833.18 EAK87527.1 - 4.1e-56 188.1 0.5 4.7e-56 188.0 0.5 1.0 1 0 0 1 1 1 1 Ribosomal S17 DUF4602 PF15375.6 EAK87528.1 - 1.2e-07 32.1 11.6 1.2e-07 32.1 11.6 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4602) WSS_VP PF12175.8 EAK87528.1 - 0.06 12.8 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 White spot syndrome virus structural envelope protein VP Acid_phosphat_B PF03767.14 EAK87528.1 - 0.2 11.2 4.5 0.32 10.6 4.5 1.5 1 1 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Ribosomal_L26 PF16906.5 EAK87528.1 - 0.34 11.4 5.4 0.11 13.0 2.1 1.8 2 0 0 2 2 2 0 Ribosomal proteins L26 eukaryotic, L24P archaeal Pet100 PF09803.9 EAK87528.1 - 3 8.4 6.9 16 6.1 6.9 2.3 1 1 0 1 1 1 0 Pet100 Ribosomal_L7Ae PF01248.26 EAK87529.1 - 2.6e-22 78.4 0.1 3.5e-22 77.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.12 EAK87529.1 - 0.022 15.0 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding zf-HIT PF04438.16 EAK87530.1 - 2.4e-08 33.7 11.0 2.4e-08 33.7 11.0 2.0 3 0 0 3 3 3 1 HIT zinc finger Snf7 PF03357.21 EAK87531.1 - 4e-22 78.6 22.9 5.2e-22 78.3 22.9 1.2 1 0 0 1 1 1 1 Snf7 RNase_PH_C PF03725.15 EAK87531.1 - 0.25 11.4 2.1 0.83 9.7 0.2 2.5 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 CpxA_peri PF16527.5 EAK87531.1 - 0.64 10.4 10.5 1.3 9.4 2.6 2.2 2 1 0 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain PIEZO PF15917.5 EAK87532.1 - 0.045 13.2 0.3 0.081 12.4 0.3 1.4 1 0 0 1 1 1 0 Piezo Mucin PF01456.17 EAK87532.1 - 0.14 12.1 19.5 0.23 11.4 19.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein ASD2 PF08687.11 EAK87532.1 - 4.9 6.6 9.9 2.5 7.6 7.7 1.5 1 1 0 1 1 1 0 Apx/Shroom domain ASD2 SNARE_assoc PF09335.11 EAK87533.1 - 5.7e-05 23.6 0.6 5.7e-05 23.6 0.6 2.8 3 0 0 3 3 3 1 SNARE associated Golgi protein ORMDL PF04061.14 EAK87533.1 - 0.003 17.4 6.1 0.0031 17.3 0.2 2.7 2 1 0 2 2 2 1 ORMDL family PepSY_TM_like_2 PF16357.5 EAK87534.1 - 6.5 6.7 5.8 8 6.4 5.4 1.5 1 1 0 1 1 1 0 Putative PepSY_TM-like BSD PF03909.17 EAK87535.1 - 3.4e-12 46.2 0.1 9.1e-12 44.8 0.1 1.6 1 0 0 1 1 1 1 BSD domain SWIM PF04434.17 EAK87536.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 SWIM zinc finger DCP1 PF06058.13 EAK87538.1 - 5.2e-35 119.9 0.8 1.7e-34 118.3 0.8 1.9 1 0 0 1 1 1 1 Dcp1-like decapping family ANTH PF07651.16 EAK87538.1 - 0.034 13.1 3.2 0.034 13.2 2.3 1.4 1 1 0 1 1 1 0 ANTH domain NADH5_C PF06455.11 EAK87538.1 - 0.15 11.6 0.1 0.51 9.9 0.0 1.9 2 0 0 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus zf-RING_11 PF17123.5 EAK87539.1 - 0.17 11.7 3.9 0.19 11.5 0.5 2.9 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_1 PF14446.6 EAK87539.1 - 1.2 9.1 3.9 0.98 9.4 0.6 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 EAK87539.1 - 2.9 8.3 7.4 33 4.9 7.7 2.8 1 1 1 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 EAK87539.1 - 4.2 7.4 7.9 1.5 8.8 4.3 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EAK87539.1 - 6.8 6.6 6.8 0.6 10.0 0.4 2.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.29 EAK87540.1 - 3.9 8.0 13.5 0.055 14.0 2.6 3.1 2 2 1 3 3 3 0 PH domain EF-hand_7 PF13499.6 EAK87541.1 - 1.9e-22 79.5 5.3 2.4e-11 43.9 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAK87541.1 - 6.6e-19 66.0 6.1 4.6e-05 22.7 0.9 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EAK87541.1 - 4.5e-18 63.6 7.4 1.5e-05 24.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EAK87541.1 - 1.3e-15 57.0 4.6 6.6e-07 29.1 0.0 4.3 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EAK87541.1 - 2.5e-13 48.9 10.5 3.7e-05 23.0 0.9 4.3 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EAK87541.1 - 1.2e-05 25.5 0.9 0.019 15.3 0.0 3.5 2 2 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 EAK87541.1 - 1.6e-05 24.8 2.4 0.14 12.2 0.2 3.1 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EAK87541.1 - 0.067 13.5 0.1 2.9 8.3 0.0 2.6 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Hydrolase_4 PF12146.8 EAK87544.1 - 1.1e-17 64.1 0.0 3.5e-17 62.5 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK87544.1 - 2e-16 60.4 0.0 2.6e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EAK87544.1 - 4.4e-06 27.5 0.0 6.1e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EAK87544.1 - 0.00026 20.6 0.2 0.00063 19.3 0.2 1.8 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Esterase PF00756.20 EAK87544.1 - 0.002 17.8 0.0 0.0033 17.1 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S15 PF02129.18 EAK87544.1 - 0.01 15.4 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EAK87544.1 - 0.024 14.1 0.0 3.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ntox21 PF15526.6 EAK87544.1 - 0.026 14.8 0.4 2.9 8.2 0.1 2.4 2 0 0 2 2 2 0 Novel toxin 21 Palm_thioest PF02089.15 EAK87544.1 - 0.072 12.9 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase TbpB_C PF17483.2 EAK87544.1 - 0.084 13.3 0.4 0.45 10.9 0.2 2.1 2 0 0 2 2 2 0 C-lobe handle domain of Tf-binding protein B DLH PF01738.18 EAK87544.1 - 0.091 12.3 0.0 0.25 10.8 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Ndr PF03096.14 EAK87544.1 - 0.1 11.3 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Ndr family Ran_BP1 PF00638.18 EAK87545.1 - 3e-39 134.1 3.3 4.5e-39 133.5 3.3 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EAK87545.1 - 0.057 13.4 4.1 0.27 11.2 4.1 2.1 1 1 0 1 1 1 0 WH1 domain zf-C3HC4_3 PF13920.6 EAK87546.1 - 6.8e-10 38.7 13.3 1.8e-09 37.3 13.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK87546.1 - 0.01 15.8 13.4 0.031 14.2 13.4 1.9 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EAK87546.1 - 0.023 14.5 13.0 0.11 12.4 13.0 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EAK87548.1 - 8.2e-10 38.4 4.4 1.7e-09 37.4 4.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK87548.1 - 0.00028 20.7 7.2 0.00089 19.1 7.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK87548.1 - 0.0013 18.6 7.1 0.0026 17.7 7.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EAK87548.1 - 0.0019 18.5 6.8 0.0019 18.5 6.8 2.3 3 0 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 EAK87548.1 - 0.015 15.2 6.7 0.044 13.7 6.7 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 YdjO PF14169.6 EAK87548.1 - 0.016 14.9 0.6 0.064 13.0 0.1 2.3 2 0 0 2 2 2 0 Cold-inducible protein YdjO zf-C3HC4_2 PF13923.6 EAK87548.1 - 0.44 10.4 5.7 4.8 7.1 5.9 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Nicastrin PF05450.15 EAK87550.1 - 0.15 11.5 0.4 10 5.5 0.1 2.3 2 0 0 2 2 2 0 Nicastrin Ins_P5_2-kin PF06090.12 EAK87551.1 - 0.017 14.6 10.4 0.048 13.1 10.4 1.7 1 1 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase LD_cluster2 PF18163.1 EAK87552.1 - 0.36 10.3 4.5 0.58 9.6 4.5 1.3 1 0 0 1 1 1 0 SLOG cluster2 zf-U1 PF06220.12 EAK87555.1 - 1.6e-17 63.0 4.5 1.6e-17 63.0 4.5 2.0 2 0 0 2 2 2 1 U1 zinc finger IMCp PF12314.8 EAK87556.1 - 4.1e-17 62.2 135.6 1.4e-10 41.3 22.6 6.7 1 1 6 7 7 7 5 Inner membrane complex protein Helicase_C PF00271.31 EAK87557.1 - 5.8e-12 45.9 3.5 2.5e-10 40.7 0.0 3.5 3 0 0 3 3 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EAK87557.1 - 2.1e-06 28.0 0.0 5.6e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EAK87557.1 - 1.2e-05 25.2 0.1 3.9e-05 23.5 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase HA2 PF04408.23 EAK87557.1 - 1.7e-05 25.0 0.0 1.7e-05 25.0 0.0 4.5 4 1 0 4 4 3 1 Helicase associated domain (HA2) CDC45 PF02724.14 EAK87557.1 - 0.00035 19.0 18.4 0.00035 19.0 18.4 3.3 2 1 1 3 3 1 1 CDC45-like protein NESP55 PF06390.12 EAK87557.1 - 0.00038 20.1 8.6 0.00038 20.1 8.6 2.6 3 0 0 3 3 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) YL1 PF05764.13 EAK87557.1 - 0.0016 18.6 31.7 0.0016 18.6 31.7 3.5 2 1 1 3 3 1 1 YL1 nuclear protein Trypan_PARP PF05887.11 EAK87557.1 - 0.0022 18.0 13.7 0.0022 18.0 13.7 3.4 4 1 0 4 4 2 1 Procyclic acidic repetitive protein (PARP) AAA_22 PF13401.6 EAK87557.1 - 0.0064 16.8 0.0 0.028 14.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EAK87557.1 - 0.013 14.6 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 EAK87557.1 - 0.039 14.1 0.0 0.13 12.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EAK87557.1 - 0.058 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EAK87557.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family ResIII PF04851.15 EAK87557.1 - 0.16 12.0 0.0 0.16 12.0 0.0 4.9 5 1 0 6 6 6 0 Type III restriction enzyme, res subunit FAM104 PF15434.6 EAK87558.1 - 4.3 7.9 8.6 0.27 11.8 0.8 2.6 2 1 1 3 3 3 0 Family 104 EF-hand_6 PF13405.6 EAK87559.1 - 0.00078 19.2 0.3 0.0072 16.2 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EAK87559.1 - 0.0044 16.5 0.1 0.052 13.1 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EAK87559.1 - 0.009 15.8 0.5 0.07 13.0 0.5 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EAK87559.1 - 0.028 14.9 0.8 0.028 14.9 0.8 2.1 2 0 0 2 2 2 0 EF-hand domain pair CHD5 PF04420.14 EAK87560.1 - 0.0002 21.2 4.1 0.00028 20.8 3.3 1.6 1 1 1 2 2 2 1 CHD5-like protein DUF4366 PF14283.6 EAK87561.1 - 0.061 13.4 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) MARVEL PF01284.23 EAK87562.1 - 4.3 7.4 11.3 0.82 9.7 7.4 1.7 2 0 0 2 2 2 0 Membrane-associating domain PP2C PF00481.21 EAK87565.1 - 1e-45 156.4 0.0 1.7e-45 155.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EAK87565.1 - 3.1e-05 24.0 0.0 9.2e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EAK87565.1 - 0.00048 19.8 0.0 0.0044 16.7 0.0 2.5 1 1 0 1 1 1 1 Protein phosphatase 2C TFIIA_gamma_N PF02268.16 EAK87567.1 - 0.048 13.7 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain DUF1948 PF09185.10 EAK87567.1 - 0.16 11.9 1.8 8.2 6.3 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1948) Proteasome PF00227.26 EAK87568.1 - 1.6e-47 161.5 0.3 2e-47 161.2 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Hexapep PF00132.24 EAK87569.1 - 0.02 14.6 4.3 0.055 13.2 4.3 1.8 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) HAD_2 PF13419.6 EAK87569.1 - 0.66 10.0 4.0 8.4 6.4 0.0 2.7 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF3522 PF12036.8 EAK87570.1 - 1.3e-16 61.5 19.7 2.1e-10 41.2 11.3 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3522) EGF_2 PF07974.13 EAK87570.1 - 0.13 12.7 10.7 0.41 11.0 10.7 1.9 1 0 0 1 1 1 0 EGF-like domain CH PF00307.31 EAK87571.1 - 9.3e-06 25.8 0.2 9.3e-06 25.8 0.2 3.8 3 1 0 3 3 3 1 Calponin homology (CH) domain BAF250_C PF12031.8 EAK87572.1 - 0.01 15.2 0.6 0.024 14.0 0.1 1.8 2 0 0 2 2 2 0 SWI/SNF-like complex subunit BAF250/Osa WD40 PF00400.32 EAK87574.1 - 9.8e-08 32.6 0.4 0.063 14.2 0.0 4.7 4 1 1 5 5 5 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EAK87574.1 - 0.02 13.9 0.1 0.058 12.4 0.1 1.9 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EAK87574.1 - 0.18 11.4 0.0 0.47 10.0 0.0 1.7 2 0 0 2 2 2 0 PQQ-like domain SNF2_N PF00176.23 EAK87577.1 - 2.7e-59 200.6 0.4 5.3e-59 199.7 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK87577.1 - 2e-17 63.5 0.0 1.7e-16 60.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain C2 PF00168.30 EAK87578.1 - 0.091 13.1 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 C2 domain Frataxin_Cyay PF01491.16 EAK87579.1 - 1.9e-23 82.6 0.2 2.9e-23 82.0 0.2 1.3 1 0 0 1 1 1 1 Frataxin-like domain DUF2396 PF09654.10 EAK87579.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2396) Methyltransf_31 PF13847.6 EAK87580.1 - 5.6e-15 55.5 0.1 8.9e-15 54.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAK87580.1 - 2.1e-08 34.8 0.0 3.9e-08 33.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK87580.1 - 1.4e-06 28.2 0.0 2e-06 27.8 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK87580.1 - 2.4e-06 28.1 0.0 4.2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK87580.1 - 4e-06 27.5 0.1 1.1e-05 26.1 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EAK87580.1 - 1.6e-05 24.9 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EAK87580.1 - 4.3e-05 23.1 0.0 7.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EAK87580.1 - 0.00022 20.6 0.1 0.00039 19.8 0.1 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EAK87580.1 - 0.0012 18.3 0.1 0.0017 17.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_20 PF12147.8 EAK87580.1 - 0.0016 17.7 0.0 0.0019 17.4 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 EAK87580.1 - 0.0022 17.8 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TrmK PF04816.12 EAK87580.1 - 0.0022 17.5 0.1 0.0062 16.1 0.0 1.7 1 1 1 2 2 2 1 tRNA (adenine(22)-N(1))-methyltransferase Methyltransf_4 PF02390.17 EAK87580.1 - 0.0048 16.4 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase tRNA_U5-meth_tr PF05958.11 EAK87580.1 - 0.019 14.0 0.1 0.05 12.6 0.1 1.6 1 1 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_9 PF08003.11 EAK87580.1 - 0.039 12.9 0.0 0.053 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MetW PF07021.12 EAK87580.1 - 0.042 13.5 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW zf-4CXXC_R1 PF10497.9 EAK87583.1 - 0.0054 16.9 9.0 0.0054 16.9 9.0 2.5 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 MAS20 PF02064.15 EAK87583.1 - 0.53 10.4 2.7 1.2 9.2 0.4 2.8 2 0 0 2 2 2 0 MAS20 protein import receptor Peptidase_S9 PF00326.21 EAK87584.1 - 3.6e-30 105.0 0.0 6.7e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EAK87584.1 - 6.5e-09 36.0 0.0 1.2e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 EAK87584.1 - 8.8e-08 31.7 0.0 0.0033 16.7 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK87584.1 - 3.9e-07 30.0 0.4 0.0013 18.5 0.4 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 EAK87584.1 - 7.9e-07 28.8 0.0 5.5e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EAK87584.1 - 0.0015 19.2 0.0 0.0039 17.8 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EAK87584.1 - 0.012 15.5 0.1 0.29 10.9 0.0 2.4 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EAK87584.1 - 0.2 11.5 0.0 2.1 8.1 0.0 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF4710 PF15828.5 EAK87585.1 - 0.13 12.4 4.1 0.46 10.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) SIL1 PF16782.5 EAK87585.1 - 0.44 9.7 13.9 1.7 7.8 2.1 2.0 1 1 1 2 2 2 0 Nucleotide exchange factor SIL1 Spore-coat_CotD PF11122.8 EAK87585.1 - 0.88 10.4 7.4 0.36 11.7 4.5 1.8 1 1 1 2 2 2 0 Inner spore coat protein D Pkinase PF00069.25 EAK87586.1 - 2.1e-18 66.6 2.8 4.3e-10 39.4 0.6 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK87586.1 - 7.5e-11 41.8 1.2 1.2e-06 28.0 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EAK87586.1 - 6.5e-05 22.4 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EAK87586.1 - 0.00018 21.0 0.1 0.25 10.6 0.1 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EAK87586.1 - 0.2 11.5 0.0 0.52 10.2 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Efg1 PF10153.9 EAK87587.1 - 2.3e-06 27.9 21.5 2.3e-06 27.9 21.5 3.3 2 2 0 2 2 2 1 rRNA-processing protein Efg1 DUF4986 PF16375.5 EAK87587.1 - 2.8 8.7 5.0 89 3.9 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function UPF0020 PF01170.18 EAK87588.1 - 1.5e-15 57.4 0.0 3.6e-14 52.9 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EAK87588.1 - 0.0002 21.2 1.4 0.0044 16.8 0.1 2.4 2 1 0 2 2 2 1 DNA methylase N6_Mtase PF02384.16 EAK87588.1 - 0.00045 19.6 0.1 0.0093 15.3 0.0 2.2 2 0 0 2 2 2 1 N-6 DNA Methylase MethyltransfD12 PF02086.15 EAK87588.1 - 0.016 14.9 1.1 0.19 11.3 0.0 2.1 1 1 1 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase PYRIN PF02758.16 EAK87590.1 - 0.033 14.3 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain TSP_1 PF00090.19 EAK87591.1 - 3.1e-27 94.5 31.7 1.2e-10 41.4 6.8 3.6 3 0 0 3 3 3 3 Thrombospondin type 1 domain EGF PF00008.27 EAK87591.1 - 0.00075 19.8 7.5 0.00075 19.8 7.5 3.1 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 EAK87591.1 - 0.072 13.8 9.1 0.081 13.6 3.3 3.5 2 0 0 2 2 2 0 Human growth factor-like EGF ATP-synt_8 PF00895.20 EAK87591.1 - 0.88 10.1 3.3 0.47 11.0 0.6 1.9 2 0 0 2 2 2 0 ATP synthase protein 8 ATG_C PF09333.11 EAK87592.1 - 4e-07 30.3 0.0 9.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EAK87592.1 - 2.2e-05 24.3 2.4 0.054 13.3 0.0 4.2 3 0 0 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EAK87593.1 - 7.5e-30 103.4 1.1 1.2e-28 99.5 0.2 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EAK87593.1 - 2.3e-07 30.9 1.8 3.6e-07 30.2 1.8 1.3 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Hexapep PF00132.24 EAK87596.1 - 2.5e-10 39.7 16.1 3.6e-07 29.7 2.6 3.8 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EAK87596.1 - 3.6e-05 23.4 11.8 0.0015 18.3 3.3 3.5 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EAK87596.1 - 0.00017 20.7 1.1 0.00026 20.0 1.1 1.2 1 0 0 1 1 1 1 L-fucokinase DDHD PF02862.17 EAK87596.1 - 0.073 13.2 2.5 0.097 12.8 2.5 1.1 1 0 0 1 1 1 0 DDHD domain DUF2457 PF10446.9 EAK87596.1 - 0.53 9.4 23.8 0.62 9.1 23.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CobT PF06213.12 EAK87596.1 - 0.62 9.4 12.4 0.73 9.2 12.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 EAK87596.1 - 1.8 6.8 15.0 2.1 6.5 15.0 1.1 1 0 0 1 1 1 0 CDC45-like protein GCIP PF13324.6 EAK87596.1 - 2 7.9 9.0 2.8 7.5 9.0 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Vfa1 PF08432.10 EAK87596.1 - 3.3 8.0 9.8 4.5 7.6 9.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SDA1 PF05285.12 EAK87596.1 - 3.5 6.9 19.6 4.5 6.6 19.6 1.1 1 0 0 1 1 1 0 SDA1 Pox_Ag35 PF03286.14 EAK87596.1 - 4.3 7.1 12.7 6.2 6.6 12.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PrmA PF06325.13 EAK87597.1 - 9e-10 38.4 0.5 9e-10 38.4 0.5 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EAK87597.1 - 7.5e-09 36.2 0.0 3e-08 34.3 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK87597.1 - 6.1e-07 29.4 0.1 2e-06 27.7 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain zf-C2H2_2 PF12756.7 EAK87597.1 - 2.4e-05 24.6 0.1 6e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Methyltransf_23 PF13489.6 EAK87597.1 - 3e-05 23.9 0.1 0.00039 20.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EAK87597.1 - 3.2e-05 23.9 0.1 7.1e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK87597.1 - 3.9e-05 24.2 0.0 0.00011 22.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EAK87597.1 - 6.5e-05 22.5 0.1 0.00014 21.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 EAK87597.1 - 0.0054 16.4 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Met_10 PF02475.16 EAK87597.1 - 0.013 15.2 0.4 0.029 14.1 0.4 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_9 PF08003.11 EAK87597.1 - 0.014 14.3 0.0 0.038 12.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_15 PF09445.10 EAK87597.1 - 0.023 14.3 0.1 0.057 13.0 0.1 1.6 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CMAS PF02353.20 EAK87597.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 EAK87597.1 - 0.049 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 EAK87597.1 - 0.069 13.9 0.4 0.86 10.4 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_16 PF10294.9 EAK87597.1 - 0.07 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EAK87597.1 - 0.099 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Adaptin_N PF01602.20 EAK87598.1 - 6.1e-87 292.3 20.8 1.2e-85 288.1 20.8 2.1 1 1 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EAK87598.1 - 1.8e-23 82.9 6.4 5.3e-23 81.5 6.4 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain RTP1_C1 PF10363.9 EAK87598.1 - 0.019 15.1 1.4 0.25 11.5 0.0 3.4 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DEAD PF00270.29 EAK87599.1 - 9.5e-23 80.9 0.1 5.7e-20 71.8 0.0 2.6 2 1 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87599.1 - 1.7e-14 54.1 4.7 2.9e-14 53.4 0.2 3.3 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK87599.1 - 4.9e-09 36.4 0.1 4.9e-09 36.4 0.1 3.5 3 1 2 5 5 5 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EAK87599.1 - 0.058 12.4 0.2 0.11 11.6 0.2 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein DUF4280 PF14107.6 EAK87599.1 - 0.067 14.0 0.3 0.35 11.7 0.3 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4280) Nup35_RRM PF05172.13 EAK87599.1 - 0.068 13.1 0.1 0.43 10.6 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif TK PF00265.18 EAK87600.1 - 4.3e-55 186.3 0.7 4.9e-55 186.1 0.7 1.0 1 0 0 1 1 1 1 Thymidine kinase AAA_22 PF13401.6 EAK87600.1 - 0.017 15.4 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Nup54 PF13874.6 EAK87601.1 - 1.5e-22 80.2 3.0 1.5e-22 80.2 3.0 3.0 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 Hydrolase_4 PF12146.8 EAK87602.1 - 1.9e-07 30.6 0.0 0.011 15.0 0.0 2.3 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EAK87602.1 - 4.1e-07 30.0 0.9 7.4e-06 25.9 0.9 2.3 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EAK87602.1 - 3.7e-05 23.5 3.0 0.016 14.9 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EAK87602.1 - 0.00081 18.9 0.0 0.0029 17.1 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Asp2 PF16929.5 EAK87602.1 - 0.002 17.2 0.1 0.002 17.2 0.1 2.0 2 0 0 2 2 2 1 Accessory Sec system GspB-transporter DLH PF01738.18 EAK87602.1 - 0.0055 16.3 0.0 0.0095 15.5 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 EAK87602.1 - 0.018 14.7 0.1 0.051 13.2 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DUF2457 PF10446.9 EAK87602.1 - 6.3 5.8 12.7 9.4 5.3 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Brix PF04427.18 EAK87603.1 - 1e-37 130.1 0.6 1.8e-37 129.3 0.5 1.4 1 1 0 1 1 1 1 Brix domain Prenyltransf PF01255.19 EAK87604.1 - 7.7e-59 198.9 0.1 9.7e-59 198.6 0.1 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF4065 PF13274.6 EAK87605.1 - 0.061 14.2 4.8 0.082 13.8 4.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) ArsC PF03960.15 EAK87605.1 - 0.073 13.1 0.5 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 ArsC family KRTAP PF11759.8 EAK87606.1 - 0.79 10.3 39.0 2.8 8.5 17.8 2.5 1 1 1 2 2 2 0 Keratin-associated matrix GAPT PF11770.8 EAK87607.1 - 0.0054 16.6 0.3 0.0065 16.3 0.3 1.2 1 0 0 1 1 1 1 GRB2-binding adapter (GAPT) PIEZO PF15917.5 EAK87607.1 - 0.0054 16.2 4.5 0.007 15.9 4.5 1.2 1 0 0 1 1 1 1 Piezo Peptidase_S49_N PF08496.10 EAK87607.1 - 0.01 15.9 2.5 0.013 15.5 2.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ly49 PF08391.10 EAK87607.1 - 0.013 15.8 1.9 0.018 15.4 1.9 1.1 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF4758 PF15950.5 EAK87607.1 - 0.079 13.3 0.3 0.095 13.0 0.3 1.1 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein PsbL PF02419.17 EAK87607.1 - 0.2 11.7 2.4 0.31 11.0 2.4 1.3 1 0 0 1 1 1 0 PsbL protein CLN3 PF02487.17 EAK87607.1 - 0.28 10.2 1.1 0.31 10.0 1.1 1.0 1 0 0 1 1 1 0 CLN3 protein ETRAMP PF09716.10 EAK87607.1 - 1.2 9.2 4.7 3.7 7.7 4.7 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4748 PF15932.5 EAK87607.1 - 1.6 8.6 4.0 0.48 10.2 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) TAP42 PF04177.12 EAK87609.1 - 5.2e-45 154.0 15.4 6.4e-45 153.7 15.4 1.1 1 0 0 1 1 1 1 TAP42-like family CID_GANP PF16766.5 EAK87609.1 - 0.0077 16.4 0.3 0.022 15.0 0.3 1.7 1 0 0 1 1 1 1 Binding region of GANP to ENY2 N2227 PF07942.12 EAK87610.1 - 1.1e-94 316.7 0.4 1.7e-94 316.0 0.4 1.3 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 EAK87610.1 - 8.6e-05 23.2 1.2 0.15 12.8 0.0 3.5 2 1 0 2 2 2 2 Methyltransferase domain ABC_tran PF00005.27 EAK87612.1 - 2.3e-11 44.4 0.0 9.8e-09 35.8 0.0 3.0 2 0 0 2 2 2 2 ABC transporter PRK PF00485.18 EAK87612.1 - 0.07 12.9 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family MobB PF03205.14 EAK87612.1 - 0.098 12.6 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EAK87612.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ResIII PF04851.15 EAK87612.1 - 0.35 10.9 2.8 0.93 9.5 0.0 2.6 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Pyrophosphatase PF00719.19 EAK87613.1 - 1.4e-43 148.5 0.0 2.1e-43 147.9 0.0 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase ABC_tran PF00005.27 EAK87614.1 - 5.7e-09 36.6 6.4 2.2e-06 28.2 3.3 4.0 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EAK87614.1 - 0.0038 17.1 2.5 0.01 15.7 0.4 2.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system zf-C3HC4_3 PF13920.6 EAK87615.1 - 1.5e-13 50.4 9.3 2.5e-13 49.7 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EAK87615.1 - 1.5e-07 31.1 11.8 3.1e-07 30.1 11.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EAK87615.1 - 0.00032 21.0 13.6 0.00032 21.0 13.6 1.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EAK87615.1 - 0.0013 18.7 11.2 0.0027 17.7 11.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain DUF3567 PF12091.8 EAK87615.1 - 0.08 13.1 0.2 0.22 11.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) DUF1644 PF07800.12 EAK87615.1 - 1.8 8.6 8.3 20 5.2 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) DUF726 PF05277.12 EAK87616.1 - 8.1e-92 307.8 2.7 8.1e-92 307.8 2.7 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF726) DUF900 PF05990.12 EAK87616.1 - 8.9e-05 22.1 0.1 0.00017 21.1 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Cutinase PF01083.22 EAK87616.1 - 0.002 18.1 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Cutinase Abhydrolase_1 PF00561.20 EAK87616.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Gly-zipper_Omp PF13488.6 EAK87617.1 - 5.5e-06 26.3 5.5 1e-05 25.4 5.5 1.4 1 0 0 1 1 1 1 Glycine zipper TraT PF05818.12 EAK87617.1 - 0.0088 15.7 0.1 0.0088 15.7 0.1 1.8 2 0 0 2 2 2 1 Enterobacterial TraT complement resistance protein DUF1269 PF06897.12 EAK87617.1 - 0.017 15.4 0.1 0.043 14.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Gly-zipper_OmpA PF13436.6 EAK87617.1 - 0.021 14.6 10.6 0.031 14.1 10.6 1.3 1 0 0 1 1 1 0 Glycine-zipper domain Gly-zipper_YMGG PF13441.6 EAK87617.1 - 0.82 9.5 9.5 1.4 8.7 9.5 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Rtf2 PF04641.12 EAK87619.1 - 2.7e-06 26.9 0.0 3.4e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Myb_DNA-bind_7 PF15963.5 EAK87620.1 - 1.7e-19 69.5 6.0 4.5e-19 68.1 6.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EAK87620.1 - 0.067 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ribosomal_L28e PF01778.17 EAK87622.1 - 2e-22 80.1 7.0 2.3e-22 79.9 7.0 1.0 1 0 0 1 1 1 1 Ribosomal L28e protein family PuR_N PF09182.10 EAK87622.1 - 0.0018 18.1 0.4 1.3 9.0 0.1 2.2 1 1 1 2 2 2 2 Bacterial purine repressor, N-terminal RRS1 PF04939.12 EAK87623.1 - 1.6e-42 145.2 3.1 1.6e-42 145.2 3.1 1.8 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) Sec8_exocyst PF04048.14 EAK87623.1 - 0.027 14.3 3.5 0.037 13.9 1.8 1.9 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF5399 PF17377.2 EAK87623.1 - 1.3 8.8 7.1 4.4 7.1 0.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5399) HIP1_clath_bdg PF16515.5 EAK87623.1 - 3.6 8.3 8.5 1.5 9.5 2.5 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SF1-HH PF16275.5 EAK87624.1 - 1.6e-30 105.8 1.3 3.7e-30 104.6 1.3 1.7 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EAK87624.1 - 6.5e-07 29.1 0.0 1.9e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 EAK87624.1 - 0.0045 17.0 1.4 0.0045 17.0 1.4 2.2 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 EAK87624.1 - 0.01 15.8 5.5 0.62 10.1 0.6 2.4 1 1 1 2 2 2 0 Zinc knuckle LRV_FeS PF05484.11 EAK87626.1 - 0.079 13.0 0.7 6.9 6.8 0.1 2.3 2 0 0 2 2 2 0 LRV protein FeS4 cluster UFD1 PF03152.14 EAK87627.1 - 9e-77 256.4 0.0 1.2e-76 256.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF1735 PF08522.10 EAK87627.1 - 0.045 14.4 2.1 0.089 13.4 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1735) CDC48_2 PF02933.17 EAK87627.1 - 0.087 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 CDC48_N PF02359.18 EAK87627.1 - 0.14 12.4 0.0 0.53 10.5 0.0 1.9 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain AAA PF00004.29 EAK87628.1 - 1.4e-42 145.3 0.0 6.1e-42 143.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EAK87628.1 - 2.1e-10 40.4 0.0 4.4e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EAK87628.1 - 6.4e-10 38.7 0.7 1.3e-09 37.7 0.7 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EAK87628.1 - 1.9e-07 31.4 0.0 4.7e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EAK87628.1 - 1.6e-05 24.7 0.0 2.9e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EAK87628.1 - 2e-05 24.8 0.2 0.0053 17.0 0.2 2.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EAK87628.1 - 2.2e-05 23.7 0.0 3.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EAK87628.1 - 6.2e-05 23.0 0.4 0.00044 20.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK87628.1 - 6.5e-05 23.4 0.2 0.00083 19.8 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EAK87628.1 - 0.0017 18.9 0.0 0.0036 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EAK87628.1 - 0.0026 17.5 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EAK87628.1 - 0.0037 17.4 0.0 0.01 16.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EAK87628.1 - 0.006 15.8 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EAK87628.1 - 0.006 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EAK87628.1 - 0.0074 15.9 1.0 0.022 14.4 0.0 2.3 3 0 0 3 3 2 1 Proteasomal ATPase OB N-terminal domain RNA_helicase PF00910.22 EAK87628.1 - 0.008 16.6 0.0 0.022 15.1 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EAK87628.1 - 0.0095 16.2 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EAK87628.1 - 0.013 15.0 0.9 0.45 10.1 0.1 2.4 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EAK87628.1 - 0.017 14.5 0.1 0.032 13.6 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EAK87628.1 - 0.027 13.8 0.1 0.87 8.9 0.1 2.3 1 1 0 2 2 2 0 KaiC AAA_24 PF13479.6 EAK87628.1 - 0.034 13.9 0.2 0.078 12.7 0.2 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EAK87628.1 - 0.034 14.1 0.1 0.47 10.4 0.0 2.2 1 1 0 2 2 2 0 NACHT domain AAA_3 PF07726.11 EAK87628.1 - 0.041 13.7 0.1 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EAK87628.1 - 0.049 13.1 0.1 0.13 11.7 0.1 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EAK87628.1 - 0.098 12.2 0.0 0.2 11.1 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EAK87628.1 - 0.11 12.2 0.2 0.28 10.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EAK87628.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EAK87628.1 - 0.12 12.9 0.0 0.48 10.9 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EAK87628.1 - 0.15 11.7 0.1 0.8 9.4 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EAK87628.1 - 0.16 11.9 0.4 1.5 8.7 0.1 2.6 2 1 0 2 2 2 0 NTPase Parvo_NS1 PF01057.17 EAK87628.1 - 0.16 11.0 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AI-2E_transport PF01594.16 EAK87630.1 - 0.018 14.2 1.3 0.028 13.6 1.3 1.3 1 0 0 1 1 1 0 AI-2E family transporter DUF4252 PF14060.6 EAK87630.1 - 0.031 14.2 0.2 0.031 14.2 0.2 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4252) DUF4834 PF16118.5 EAK87630.1 - 0.047 14.6 0.8 0.11 13.5 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 EAK87630.1 - 0.061 13.9 0.0 0.19 12.4 0.0 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF5383 PF17355.2 EAK87630.1 - 0.24 11.8 0.3 0.24 11.8 0.3 2.9 3 1 2 5 5 5 0 Family of unknown function (DUF5383) YMF19 PF02326.15 EAK87630.1 - 2.2 9.1 8.0 0.6 10.9 4.4 2.0 2 1 0 2 2 2 0 Plant ATP synthase F0 Thioredoxin PF00085.20 EAK87631.1 - 1.9e-31 108.1 0.4 4.8e-19 68.3 0.0 3.9 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_8 PF13905.6 EAK87631.1 - 2.8e-05 24.4 3.8 0.31 11.4 0.0 4.9 3 1 1 5 5 5 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EAK87631.1 - 0.00048 20.3 0.0 0.11 12.7 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EAK87631.1 - 0.00051 20.5 0.5 1.2 9.6 0.2 3.4 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EAK87631.1 - 0.0017 18.2 0.1 0.34 10.7 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin Glutaredoxin PF00462.24 EAK87631.1 - 0.002 18.3 1.8 1.2 9.4 0.0 3.6 3 0 0 3 3 3 1 Glutaredoxin AhpC-TSA PF00578.21 EAK87631.1 - 0.014 15.3 0.0 10 6.0 0.0 3.0 3 0 0 3 3 3 0 AhpC/TSA family Bud13 PF09736.9 EAK87632.1 - 7.5e-26 91.3 4.8 1e-25 90.8 4.8 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex Tox-REase-9 PF15650.6 EAK87632.1 - 0.075 13.3 1.8 0.39 11.0 0.0 2.3 1 1 1 2 2 2 0 Restriction endonuclease fold toxin 9 Lactamase_B_2 PF12706.7 EAK87633.1 - 2.7e-13 49.9 0.0 5.6e-08 32.5 0.0 2.2 1 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EAK87633.1 - 0.00014 21.3 0.6 0.00035 20.0 0.3 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EAK87633.1 - 0.025 14.6 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily SMI1_KNR4 PF09346.10 EAK87633.1 - 0.079 13.4 1.7 0.19 12.1 1.7 1.7 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Ribosomal_L50 PF10501.9 EAK87633.1 - 1.1 9.4 9.1 0.6 10.3 6.7 1.8 2 0 0 2 2 2 0 Ribosomal subunit 39S AP2 PF00847.20 EAK87634.1 - 4.8e-29 100.4 16.1 1.5e-18 66.7 2.6 4.0 4 1 0 4 4 4 2 AP2 domain HTH_43 PF09904.9 EAK87634.1 - 0.065 13.2 0.1 0.24 11.3 0.1 1.9 1 0 0 1 1 1 0 Winged helix-turn helix DUF3135 PF11333.8 EAK87634.1 - 0.13 12.5 1.5 0.51 10.6 1.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) MPM1 PF17234.2 EAK87635.1 - 0.0041 17.4 4.4 0.0041 17.4 4.4 3.5 2 1 1 4 4 4 1 Mitochondrial peculiar membrane protein 1 NopRA1 PF16201.5 EAK87637.1 - 7.8e-18 64.8 9.8 5.3e-16 58.8 2.7 2.8 2 0 0 2 2 2 2 Nucleolar pre-ribosomal-associated protein 1 Nop14 PF04147.12 EAK87637.1 - 0.00027 19.3 24.7 0.00027 19.3 24.7 2.4 3 0 0 3 3 3 1 Nop14-like family DUF2052 PF09747.9 EAK87637.1 - 0.026 14.7 30.1 0.056 13.6 23.3 2.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 EAK87637.1 - 0.085 11.6 19.8 0.015 14.1 14.7 2.0 2 0 0 2 2 2 0 Presenilin CDC45 PF02724.14 EAK87637.1 - 0.76 8.0 32.5 0.069 11.4 25.6 2.1 2 0 0 2 2 2 0 CDC45-like protein CLN3 PF02487.17 EAK87637.1 - 2.3 7.2 19.7 0.33 10.0 6.8 2.6 2 0 0 2 2 2 0 CLN3 protein GAGA_bind PF06217.12 EAK87637.1 - 2.8 8.2 14.2 0.86 9.8 6.9 2.5 2 0 0 2 2 2 0 GAGA binding protein-like family BUD22 PF09073.10 EAK87637.1 - 4.2 6.6 27.6 0.39 10.0 21.4 2.0 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 EAK87637.1 - 5.7 6.3 36.0 0.33 10.3 28.1 2.1 2 0 0 2 2 2 0 SDA1 Neur_chan_memb PF02932.16 EAK87637.1 - 5.9 6.9 9.5 0.86 9.6 5.5 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PGA2 PF07543.12 EAK87637.1 - 7.5 6.5 29.1 5.4 7.0 23.0 2.5 2 0 0 2 2 2 0 Protein trafficking PGA2 DDHD PF02862.17 EAK87638.1 - 0.051 13.7 8.6 0.42 10.8 0.0 3.4 4 0 0 4 4 4 0 DDHD domain ORC_WH_C PF18137.1 EAK87638.1 - 3.9 7.5 16.3 0.53 10.4 9.7 2.7 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal CobT PF06213.12 EAK87638.1 - 5.1 6.4 16.9 0.24 10.8 10.1 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF4834 PF16118.5 EAK87638.1 - 6.2 7.8 31.4 0.28 12.2 5.5 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Rxt3 PF08642.10 EAK87638.1 - 8.4 7.2 9.2 26 5.6 2.3 2.8 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 Connexin PF00029.19 EAK87638.1 - 8.5 6.1 20.2 0.14 11.9 5.8 3.2 3 0 0 3 3 3 0 Connexin Presenilin PF01080.17 EAK87639.1 - 1.7 7.3 3.7 1.8 7.2 3.7 1.0 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 EAK87639.1 - 2.1 7.1 16.0 2.2 7.0 16.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pkinase PF00069.25 EAK87640.1 - 3.2e-26 92.3 0.0 5.1e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK87640.1 - 5e-18 65.3 0.0 7.2e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MCM PF00493.23 EAK87642.1 - 3.3e-100 333.8 0.0 5.4e-100 333.1 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EAK87642.1 - 3.5e-27 94.7 2.0 6.9e-27 93.8 2.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EAK87642.1 - 3.3e-18 65.9 0.8 7.7e-18 64.7 0.8 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EAK87642.1 - 1.4e-13 51.3 1.4 6.5e-13 49.2 1.4 2.2 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EAK87642.1 - 4.2e-09 36.1 0.2 9.2e-06 25.2 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EAK87642.1 - 6.3e-06 26.1 0.0 1.4e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EAK87642.1 - 2.6e-05 24.3 0.0 0.00012 22.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK87642.1 - 0.0054 17.1 0.3 0.085 13.2 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 EAK87642.1 - 0.046 13.4 0.3 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EAK87642.1 - 0.051 13.5 1.2 42 4.0 0.0 3.5 2 1 1 3 3 3 0 NTPase WD40 PF00400.32 EAK87643.1 - 3.1e-16 59.5 12.6 0.00023 21.9 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK87643.1 - 2.6e-08 34.1 0.4 0.75 10.1 0.0 5.1 4 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EAK87643.1 - 1.6e-05 24.0 0.2 0.46 9.4 0.0 3.9 4 0 0 4 4 4 3 Partner and localizer of BRCA2 WD40 domain DUF1493 PF07377.12 EAK87643.1 - 0.084 13.3 0.3 0.55 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1493) DUF3945 PF13101.6 EAK87643.1 - 0.63 9.8 2.4 18 5.1 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF3945) Inos-1-P_synth PF01658.17 EAK87644.1 - 6.8 7.0 8.7 0.33 11.2 0.3 2.6 3 0 0 3 3 3 0 Myo-inositol-1-phosphate synthase PAP_central PF04928.17 EAK87645.1 - 9.6e-105 349.0 0.0 9.6e-105 349.0 0.0 1.9 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EAK87645.1 - 2e-19 69.8 5.4 1.5e-14 54.0 0.3 3.1 2 1 1 3 3 3 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EAK87645.1 - 9.2e-08 32.3 0.0 2.9e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Glycoprot_B_PH2 PF17417.2 EAK87645.1 - 3.9 7.9 7.0 1.5 9.2 3.0 2.4 1 1 0 2 2 2 0 Herpesvirus Glycoprotein B PH-like domain His_Phos_2 PF00328.22 EAK87646.1 - 1.7e-20 73.8 2.9 4.8e-20 72.3 2.9 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.22 EAK87647.1 - 4.4e-18 65.8 1.1 1.2e-17 64.4 1.1 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) WD40 PF00400.32 EAK87648.1 - 1.2e-39 133.5 32.9 2.7e-05 24.8 0.2 11.5 11 1 0 11 11 11 8 WD domain, G-beta repeat Utp13 PF08625.11 EAK87648.1 - 4.4e-20 72.0 4.8 9.5e-20 70.9 4.8 1.6 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EAK87648.1 - 2e-16 60.1 2.4 0.0028 17.9 0.1 6.3 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EAK87648.1 - 6.1e-05 21.9 14.7 0.59 8.7 0.1 5.0 2 1 2 5 5 5 4 Nucleoporin Nup120/160 Myb_DNA-binding PF00249.31 EAK87649.1 - 3.4e-09 36.7 0.3 3.4e-09 36.7 0.3 3.0 2 2 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 EAK87649.1 - 4e-08 32.9 9.3 7.4e-08 32.1 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 EAK87649.1 - 2.9e-06 27.4 0.6 2.2e-05 24.6 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain C1_2 PF03107.16 EAK87649.1 - 0.12 12.7 7.4 0.31 11.4 7.4 1.7 1 0 0 1 1 1 0 C1 domain DNA_pol_lambd_f PF10391.9 EAK87649.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.8 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda WWE PF02825.20 EAK87651.1 - 8.1e-10 39.2 0.4 2.2e-09 37.7 0.4 1.8 1 0 0 1 1 1 1 WWE domain Es2 PF09751.9 EAK87653.1 - 0.0042 16.9 17.3 0.0078 16.0 0.2 2.7 2 1 0 2 2 2 2 Nuclear protein Es2 Ribosomal_L24e PF01246.20 EAK87654.1 - 3e-26 91.4 0.6 3e-26 91.4 0.6 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e WD40 PF00400.32 EAK87655.1 - 4.1e-23 81.2 12.2 6.2e-06 26.9 1.6 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK87655.1 - 1.8e-09 37.7 0.0 6.7 7.1 0.0 6.0 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EAK87655.1 - 0.00072 18.0 0.3 0.0012 17.2 0.1 1.4 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EAK87655.1 - 0.00092 18.3 0.0 0.0059 15.6 0.1 2.2 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein CSTF1_dimer PF16699.5 EAK87655.1 - 0.0032 17.2 0.1 0.0084 15.9 0.1 1.7 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain UDPGP PF01704.18 EAK87656.1 - 1.1e-30 106.7 8.1 1.7e-30 106.0 8.1 1.3 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Yip1 PF04893.17 EAK87657.1 - 7e-08 32.4 12.0 1.1e-07 31.7 12.0 1.2 1 0 0 1 1 1 1 Yip1 domain DUF2374 PF09574.10 EAK87657.1 - 0.012 15.4 0.2 0.027 14.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (Duf2374) DNA_topoisoIV PF00521.20 EAK87659.1 - 4.6e-121 404.7 8.2 4.6e-84 282.8 0.0 2.8 2 0 0 2 2 2 2 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EAK87659.1 - 1.1e-43 148.5 9.1 1.1e-43 148.5 9.1 3.0 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EAK87659.1 - 8.3e-20 71.0 0.4 8.3e-20 71.0 0.4 2.4 2 0 0 2 2 2 1 DNA gyrase B HATPase_c PF02518.26 EAK87659.1 - 6.4e-11 42.8 0.1 2.4e-10 40.9 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EAK87659.1 - 2.4e-06 27.7 0.0 9.4e-06 25.8 0.0 2.1 1 0 0 1 1 1 1 Toprim domain Kazal_2 PF07648.15 EAK87660.1 - 1.9e-42 143.1 68.7 1.5e-08 34.6 0.2 8.3 8 0 0 8 8 8 7 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EAK87660.1 - 4e-29 100.4 66.3 7.8e-08 32.2 0.3 7.8 8 0 0 8 8 8 7 Kazal-type serine protease inhibitor domain Methyltransf_10 PF05971.12 EAK87660.1 - 0.16 11.3 0.3 0.26 10.6 0.3 1.2 1 0 0 1 1 1 0 RNA methyltransferase RRM_1 PF00076.22 EAK87661.1 - 3.8e-06 26.6 0.0 0.0053 16.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAK87661.1 - 0.0082 16.0 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 1 Occluded RNA-recognition motif POR_N PF01855.19 EAK87662.1 - 1e-69 234.8 0.2 3.2e-69 233.2 0.3 1.7 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg FAD_binding_1 PF00667.20 EAK87662.1 - 5.2e-33 114.5 0.0 9.3e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain POR PF01558.18 EAK87662.1 - 5.4e-30 104.8 0.0 9.8e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Flavodoxin_1 PF00258.25 EAK87662.1 - 2.9e-26 92.4 0.1 6.7e-26 91.2 0.1 1.7 1 0 0 1 1 1 1 Flavodoxin EKR PF10371.9 EAK87662.1 - 2.7e-19 68.7 0.0 1.6e-18 66.2 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function NAD_binding_1 PF00175.21 EAK87662.1 - 3.2e-10 40.6 0.1 1.6e-09 38.4 0.0 2.4 2 0 0 2 2 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 EAK87662.1 - 1.5e-09 38.0 0.1 6.5e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer4 PF00037.27 EAK87662.1 - 3.5e-09 36.1 19.2 1.8e-05 24.3 3.2 3.5 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_16 PF13484.6 EAK87662.1 - 8.2e-09 36.3 5.1 0.0027 18.6 0.2 3.0 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 EAK87662.1 - 1.6e-08 35.0 6.3 1.6e-08 35.0 6.3 2.4 2 0 0 2 2 1 1 4Fe-4S dicluster domain TPP_enzyme_C PF02775.21 EAK87662.1 - 1.8e-08 34.3 0.0 5.8e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fer4_10 PF13237.6 EAK87662.1 - 3.4e-08 33.5 5.6 3.4e-08 33.5 5.6 2.5 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EAK87662.1 - 4.9e-07 29.8 10.9 5.5e-06 26.4 11.0 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EAK87662.1 - 2.7e-06 27.5 11.3 5.9e-06 26.3 9.0 2.6 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.6 EAK87662.1 - 8.6e-05 22.9 3.7 8.6e-05 22.9 3.7 2.5 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EAK87662.1 - 0.0002 21.3 4.9 0.0002 21.3 4.9 3.4 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4_17 PF13534.6 EAK87662.1 - 0.00031 21.2 6.6 0.00031 21.2 6.6 2.6 2 1 0 2 2 1 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 EAK87662.1 - 0.0025 18.0 4.3 0.0059 16.8 2.9 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 EAK87662.1 - 0.082 13.5 9.8 0.73 10.4 0.5 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Flavodoxin_5 PF12724.7 EAK87662.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain Fer4_2 PF12797.7 EAK87662.1 - 0.26 11.5 28.2 0.017 15.2 2.9 3.5 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_4 PF12800.7 EAK87662.1 - 1.6 9.5 16.5 0.45 11.2 1.2 3.6 3 0 0 3 3 2 0 4Fe-4S binding domain Cbl_N2 PF02761.14 EAK87662.1 - 5.6 7.7 5.0 4.9 7.9 0.0 3.4 4 0 0 4 4 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Fer4_15 PF13459.6 EAK87662.1 - 8.8 7.1 6.8 10 6.9 0.6 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain DUF3591 PF12157.8 EAK87665.1 - 3.7e-37 128.0 0.0 5.6e-13 48.4 0.0 3.5 3 0 0 3 3 3 3 Protein of unknown function (DUF3591) Bromodomain PF00439.25 EAK87665.1 - 1.5e-14 53.8 0.2 3.7e-14 52.5 0.2 1.7 1 0 0 1 1 1 1 Bromodomain zf-CCHC_6 PF15288.6 EAK87665.1 - 0.0014 18.4 1.2 0.0033 17.2 1.2 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EAK87665.1 - 0.002 18.1 0.5 0.0044 17.0 0.5 1.6 1 0 0 1 1 1 1 Zinc knuckle fn3 PF00041.21 EAK87666.1 - 7.9e-08 32.5 0.0 7e-06 26.3 0.0 3.2 2 0 0 2 2 2 1 Fibronectin type III domain DrrA_P4M PF14860.6 EAK87666.1 - 8.7 6.3 9.1 2.5 8.0 1.6 2.8 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Diphthami_syn_2 PF01902.17 EAK87667.1 - 8.1e-33 113.8 0.0 1.8e-32 112.6 0.0 1.5 1 0 0 1 1 1 1 Diphthamide synthase DUF4488 PF14869.6 EAK87667.1 - 0.18 11.7 2.3 3.8 7.5 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4488) AP2 PF00847.20 EAK87668.1 - 1.1e-06 28.8 0.1 3.3e-06 27.2 0.1 1.9 1 0 0 1 1 1 1 AP2 domain NTF2 PF02136.20 EAK87669.1 - 4.4e-35 120.9 0.2 4.9e-35 120.7 0.2 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EAK87669.1 - 0.053 13.9 0.0 0.068 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DUF4518 PF15008.6 EAK87669.1 - 0.14 11.3 0.4 0.18 10.9 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) EPL1 PF10513.9 EAK87670.1 - 2.8e-10 40.8 1.6 4.1e-10 40.3 0.2 2.1 2 0 0 2 2 2 1 Enhancer of polycomb-like Arm-DNA-bind_5 PF17293.2 EAK87670.1 - 2.6 8.5 6.3 22 5.6 1.1 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain RAP1 PF07218.11 EAK87670.1 - 4.1 5.6 7.8 0.25 9.6 2.0 1.9 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Minor_capsid_3 PF12691.7 EAK87672.1 - 0.0043 17.4 1.0 0.0096 16.3 1.0 1.6 1 0 0 1 1 1 1 Minor capsid protein from bacteriophage AAA_11 PF13086.6 EAK87672.1 - 0.018 14.8 3.8 0.033 14.0 3.8 1.4 1 0 0 1 1 1 0 AAA domain FlxA PF14282.6 EAK87672.1 - 0.022 14.7 3.2 0.022 14.7 3.2 3.4 4 0 0 4 4 4 0 FlxA-like protein zf-AD PF07776.15 EAK87672.1 - 0.03 14.6 0.3 0.12 12.7 0.3 2.1 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) DUF2746 PF10874.8 EAK87672.1 - 0.33 11.4 3.2 6.6 7.2 0.0 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF2746) DivIC PF04977.15 EAK87672.1 - 0.75 9.6 5.2 22 4.9 4.5 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF3958 PF13125.6 EAK87672.1 - 1.2 9.4 12.6 0.071 13.3 4.6 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3958) SlyX PF04102.12 EAK87672.1 - 3.2 8.4 6.9 1 10.0 2.2 2.5 3 0 0 3 3 3 0 SlyX Ly49 PF08391.10 EAK87672.1 - 9.6 6.6 9.1 2 8.8 3.9 2.4 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region SAP PF02037.27 EAK87673.1 - 0.13 12.0 0.0 0.42 10.4 0.0 1.9 2 0 0 2 2 2 0 SAP domain VWA_2 PF13519.6 EAK87674.1 - 1.4e-15 57.8 0.1 9.6e-15 55.2 0.0 2.4 2 1 0 2 2 2 1 von Willebrand factor type A domain Shikimate_DH PF01488.20 EAK87674.1 - 0.067 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UIM PF02809.20 EAK87674.1 - 0.12 12.3 5.2 1.3 9.2 0.3 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif V-ATPase_C PF03223.15 EAK87675.1 - 2.4e-94 316.8 5.1 3e-94 316.5 5.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Glyco_hydro_31 PF01055.26 EAK87675.1 - 0.018 14.2 0.4 0.066 12.4 0.2 2.0 1 1 1 2 2 2 0 Glycosyl hydrolases family 31 SKA2 PF16740.5 EAK87675.1 - 0.12 12.2 3.4 0.99 9.2 0.1 2.9 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF4407 PF14362.6 EAK87675.1 - 0.41 9.9 1.7 1.6 8.0 1.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) BLM10_mid PF16507.5 EAK87677.1 - 2.1e-30 105.9 10.4 2.1e-30 105.9 10.4 2.5 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EAK87677.1 - 6.2e-24 83.7 0.0 2.5e-23 81.8 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) XPG_N PF00752.17 EAK87678.1 - 2.6e-27 95.2 0.0 8.7e-27 93.6 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EAK87678.1 - 9.7e-23 80.4 0.0 9.7e-23 80.4 0.0 3.6 3 1 1 4 4 4 1 XPG I-region 5_3_exonuc PF01367.20 EAK87678.1 - 0.008 16.8 1.1 0.17 12.5 0.0 3.7 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold Trypan_PARP PF05887.11 EAK87678.1 - 0.96 9.4 50.3 0.092 12.7 37.0 3.3 2 1 1 3 3 3 0 Procyclic acidic repetitive protein (PARP) ORC5_C PF14630.6 EAK87679.1 - 1.6e-25 90.2 0.0 2.5e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus NADH_dh_m_C1 PF15088.6 EAK87680.1 - 0.011 15.3 0.2 0.036 13.7 0.2 1.9 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial DUF4293 PF14126.6 EAK87680.1 - 6.6 7.0 14.7 42 4.4 14.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) Ninjurin PF04923.12 EAK87680.1 - 8 6.5 7.7 7.7 6.5 0.8 2.8 3 0 0 3 3 3 0 Ninjurin MFS_1 PF07690.16 EAK87681.1 - 3.1e-23 82.3 38.7 3.2e-17 62.5 9.0 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Spore_GerAC PF05504.11 EAK87681.1 - 1 9.6 8.3 1.5 9.0 8.3 1.2 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Orf78 PF06024.12 EAK87681.1 - 2.7 8.4 6.9 0.26 11.6 0.3 2.8 3 0 0 3 3 3 0 Orf78 (ac78) HEAT_2 PF13646.6 EAK87682.1 - 3.7e-20 72.1 0.6 4.2e-11 43.1 0.0 2.7 3 0 0 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 EAK87682.1 - 1.5e-11 43.8 0.0 0.24 12.2 0.0 5.7 5 0 0 5 5 5 3 PBS lyase HEAT-like repeat HEAT PF02985.22 EAK87682.1 - 1.9e-10 40.1 0.1 0.34 11.3 0.0 6.4 7 0 0 7 7 7 2 HEAT repeat DUF3385 PF11865.8 EAK87682.1 - 0.019 14.9 0.4 1.2 9.0 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EAK87682.1 - 0.02 15.0 1.7 1.1 9.3 0.2 2.8 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 EAK87682.1 - 0.02 15.2 0.0 0.099 13.0 0.0 2.3 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.6 EAK87682.1 - 0.091 13.3 0.0 36 5.0 0.0 4.1 5 0 0 5 5 5 0 HEAT-like repeat TPR_1 PF00515.28 EAK87683.1 - 5.8e-11 41.7 1.5 0.00023 20.8 0.3 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EAK87683.1 - 8.1e-10 38.1 0.5 0.00031 20.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EAK87683.1 - 1.4e-05 24.9 4.8 0.091 13.0 0.4 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EAK87683.1 - 0.02 15.2 0.1 2.4 8.5 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EAK87683.1 - 0.055 14.1 0.3 1.8 9.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ECH_2 PF16113.5 EAK87683.1 - 0.7 9.3 4.1 0.23 10.9 0.2 1.9 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase SET PF00856.28 EAK87684.1 - 8.4e-12 45.8 0.4 8.4e-12 45.8 0.4 2.6 2 2 0 2 2 2 1 SET domain TPR_2 PF07719.17 EAK87685.1 - 3.8e-15 54.7 6.6 0.012 15.7 0.0 7.1 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EAK87685.1 - 2.7e-11 42.8 9.3 0.0061 16.3 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EAK87685.1 - 9.1e-09 35.4 0.0 0.14 12.8 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EAK87685.1 - 6.3e-07 29.6 0.2 0.95 9.8 0.0 5.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EAK87685.1 - 0.00013 22.5 0.0 0.091 13.6 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK87685.1 - 0.00021 21.4 5.9 9.9 6.5 0.0 6.1 6 1 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EAK87685.1 - 0.0015 18.5 9.0 2.4 8.6 0.1 5.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EAK87685.1 - 0.0091 16.0 1.3 38 4.6 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EAK87685.1 - 0.014 15.1 0.0 3.9 7.3 0.0 3.7 3 0 0 3 3 3 0 TPR repeat TPR_3 PF07720.12 EAK87685.1 - 0.15 12.1 5.6 40 4.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EAK87685.1 - 0.35 10.8 3.7 6.1 6.9 0.0 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat Med24_N PF11277.8 EAK87686.1 - 0.0029 15.8 0.0 0.0033 15.6 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal TBCC PF07986.12 EAK87687.1 - 1.4e-15 57.0 7.6 2.7e-15 56.2 7.6 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EAK87687.1 - 2.6e-05 23.9 3.8 4.7e-05 23.1 2.3 2.2 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) C terminal Abhydrolase_3 PF07859.13 EAK87688.1 - 8.5e-37 127.1 0.0 1e-36 126.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EAK87688.1 - 4.6e-08 32.4 0.3 1.1e-06 27.8 0.3 2.1 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EAK87688.1 - 0.00047 19.1 0.1 0.0013 17.7 0.1 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EAK87688.1 - 0.1 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family PWI PF01480.17 EAK87688.1 - 0.11 12.8 0.1 0.24 11.8 0.1 1.5 1 0 0 1 1 1 0 PWI domain CBFD_NFYB_HMF PF00808.23 EAK87689.1 - 2.5e-12 46.9 0.0 4.9e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EAK87689.1 - 2e-08 34.6 0.1 2e-08 34.6 0.1 1.9 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EAK87689.1 - 0.031 14.5 0.0 0.078 13.2 0.0 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) TFIID_20kDa PF03847.13 EAK87689.1 - 0.048 14.2 0.0 0.13 12.8 0.0 1.8 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A PH_BEACH PF14844.6 EAK87689.1 - 1.8 8.7 5.0 1.2 9.2 0.1 2.9 3 0 0 3 3 3 0 PH domain associated with Beige/BEACH TUDOR PF00567.24 EAK87690.1 - 1.5e-06 28.3 0.0 5.9e-05 23.1 0.0 2.7 2 1 0 2 2 2 1 Tudor domain PilJ PF13675.6 EAK87690.1 - 0.032 14.3 1.2 0.04 13.9 0.1 1.7 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term SMN PF06003.12 EAK87690.1 - 2.9 7.1 7.0 0.21 10.8 0.3 2.0 1 1 0 2 2 2 0 Survival motor neuron protein (SMN) E3_UFM1_ligase PF09743.9 EAK87691.1 - 1.3e-42 146.3 15.8 1.3e-42 146.3 15.8 1.8 2 0 0 2 2 2 1 E3 UFM1-protein ligase 1 HTH_24 PF13412.6 EAK87691.1 - 0.0041 16.6 0.4 0.025 14.1 0.1 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding FeoC PF09012.10 EAK87691.1 - 0.04 14.0 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_11 PF08279.12 EAK87691.1 - 0.052 13.5 1.4 0.18 11.8 0.2 2.5 2 0 0 2 2 2 0 HTH domain WD40 PF00400.32 EAK87692.1 - 9.4e-07 29.4 3.8 1.2 10.1 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Sec16_C PF12931.7 EAK87692.1 - 3.5e-05 23.6 2.5 0.001 18.8 0.3 3.4 2 1 0 2 2 2 1 Sec23-binding domain of Sec16 ANAPC4_WD40 PF12894.7 EAK87692.1 - 0.00016 21.9 0.0 0.46 10.8 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Prp18 PF02840.15 EAK87692.1 - 0.00026 21.1 0.4 0.0024 17.9 0.0 2.5 2 1 0 2 2 2 1 Prp18 domain SRA1 PF07304.11 EAK87692.1 - 0.0007 19.4 0.0 0.0007 19.4 0.0 3.0 2 1 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Phage_CII PF05269.11 EAK87692.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage CII protein DUF2115 PF09888.9 EAK87693.1 - 4.4 7.8 9.5 0.28 11.7 0.4 3.0 1 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) DUF3879 PF12995.7 EAK87694.1 - 0.0065 16.2 0.4 0.0072 16.1 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3879) DUF2095 PF09868.9 EAK87697.1 - 0.035 14.1 0.8 0.043 13.8 0.8 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) MMS19_N PF14500.6 EAK87698.1 - 7.6e-18 65.0 0.1 1.8e-12 47.4 0.0 3.7 3 1 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II HJURP_C PF12347.8 EAK87698.1 - 0.1 12.6 0.3 0.67 10.0 0.1 2.3 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF4477 PF14780.6 EAK87699.1 - 0.013 15.1 11.5 0.046 13.3 0.1 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4477) Syntaxin-6_N PF09177.11 EAK87699.1 - 0.078 13.5 5.5 0.51 10.9 0.8 2.8 2 1 1 3 3 3 0 Syntaxin 6, N-terminal HTH_9 PF08221.11 EAK87700.1 - 3e-06 27.2 2.8 0.0067 16.5 0.2 4.3 3 1 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain UPF0240 PF06784.11 EAK87700.1 - 0.051 13.6 0.9 0.1 12.6 0.2 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) SNF2_N PF00176.23 EAK87701.1 - 6e-52 176.5 0.0 2.2e-24 85.8 0.0 3.5 2 1 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK87701.1 - 7.3e-17 61.7 0.0 1.4e-15 57.6 0.0 3.1 2 1 1 3 3 3 1 Helicase conserved C-terminal domain zf-RING_11 PF17123.5 EAK87701.1 - 7.8e-06 25.5 7.0 9.7e-06 25.2 4.4 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 EAK87701.1 - 8.6e-06 26.0 3.0 8.6e-06 26.0 3.0 3.4 4 1 0 4 4 2 1 Ring finger domain zf-C3HC4 PF00097.25 EAK87701.1 - 5.1e-05 23.1 3.1 5.1e-05 23.1 3.1 3.1 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK87701.1 - 0.00015 21.5 2.0 0.00015 21.5 2.0 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-PARP PF00645.18 EAK87701.1 - 0.00073 20.4 0.1 0.00073 20.4 0.1 5.6 5 2 1 6 6 4 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-rbx1 PF12678.7 EAK87701.1 - 0.00083 19.6 0.5 0.00083 19.6 0.5 2.6 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C2HC_2 PF13913.6 EAK87701.1 - 0.017 15.0 0.4 0.096 12.6 0.4 2.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-ANAPC11 PF12861.7 EAK87701.1 - 0.046 13.8 0.8 0.13 12.4 0.1 2.1 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EAK87701.1 - 0.22 11.7 5.4 2.1 8.6 2.7 3.3 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 EAK87701.1 - 0.34 11.0 5.0 0.28 11.2 0.8 2.8 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING-like PF08746.11 EAK87701.1 - 0.36 11.2 8.5 0.043 14.1 2.3 2.8 2 0 0 2 2 2 0 RING-like domain zf-Di19 PF05605.12 EAK87701.1 - 1.7 9.0 6.3 5.2 7.4 0.1 3.8 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Zf_RING PF16744.5 EAK87701.1 - 3.8 7.7 8.1 4 7.6 1.0 3.7 4 0 0 4 4 4 0 KIAA1045 RING finger RRM_1 PF00076.22 EAK87702.1 - 0.0054 16.5 0.0 0.02 14.7 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUI1 PF01253.22 EAK87703.1 - 9e-19 67.8 0.1 2.7e-18 66.2 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor SUI1 PUA PF01472.20 EAK87703.1 - 0.0014 18.5 0.0 0.0051 16.8 0.0 2.0 1 1 0 1 1 1 1 PUA domain Syja_N PF02383.18 EAK87704.1 - 2.8e-73 247.0 1.2 5.2e-73 246.1 1.2 1.4 1 0 0 1 1 1 1 SacI homology domain RRP7 PF12923.7 EAK87705.1 - 8.8e-20 71.0 8.7 1.3e-19 70.4 8.7 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Ribosomal_L14e PF01929.17 EAK87705.1 - 0.00033 21.1 5.2 0.00039 20.9 4.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L14 RRM_7 PF16367.5 EAK87705.1 - 0.067 13.3 0.4 0.28 11.3 0.0 2.0 2 1 0 2 2 2 0 RNA recognition motif COX6C PF02937.15 EAK87705.1 - 0.31 11.2 3.6 8.3 6.6 1.5 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc ThiF PF00899.21 EAK87707.1 - 1.7e-33 116.0 0.0 2.7e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 ThiF family DUF4548 PF15081.6 EAK87707.1 - 0.034 14.0 0.0 0.08 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) DNA_primase_S PF01896.19 EAK87710.1 - 3.3e-60 203.1 1.9 6.6e-60 202.2 1.9 1.5 1 0 0 1 1 1 1 DNA primase small subunit V_ATPase_I PF01496.19 EAK87711.1 - 5.3e-255 848.3 7.8 6.2e-255 848.0 7.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Minor_capsid_3 PF12691.7 EAK87711.1 - 0.61 10.5 8.3 2 8.8 0.6 3.0 3 0 0 3 3 3 0 Minor capsid protein from bacteriophage FAM184 PF15665.5 EAK87711.1 - 6.2 6.5 5.9 1.9 8.3 0.0 2.6 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B RIBIOP_C PF04950.12 EAK87712.1 - 1.6e-79 267.4 0.2 1.6e-79 267.4 0.2 2.0 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EAK87712.1 - 3.4e-25 87.9 0.0 1.3e-24 86.1 0.0 2.1 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_33 PF13671.6 EAK87712.1 - 2.3e-05 24.6 0.0 8.3e-05 22.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EAK87712.1 - 5.9e-05 23.5 0.0 0.00021 21.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 EAK87712.1 - 6.1e-05 22.7 0.0 0.0019 17.8 0.0 2.6 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EAK87712.1 - 6.8e-05 23.2 0.0 0.00022 21.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EAK87712.1 - 8.7e-05 22.3 0.0 0.00024 20.8 0.0 1.7 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EAK87712.1 - 0.00071 19.2 0.0 0.0015 18.2 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EAK87712.1 - 0.00077 19.9 0.0 0.0026 18.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 EAK87712.1 - 0.0017 18.3 0.1 0.005 16.8 0.1 1.8 1 0 0 1 1 1 1 NTPase MMR_HSR1 PF01926.23 EAK87712.1 - 0.0041 17.2 0.2 0.021 14.9 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EAK87712.1 - 0.0044 16.8 0.0 0.0084 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EAK87712.1 - 0.0073 16.2 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Viral_helicase1 PF01443.18 EAK87712.1 - 0.0083 15.9 0.0 0.035 13.9 0.0 2.1 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 EAK87712.1 - 0.011 14.9 0.0 0.026 13.7 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EAK87712.1 - 0.016 15.8 0.0 0.016 15.8 0.0 3.9 5 1 0 5 5 2 0 AAA domain AAA_14 PF13173.6 EAK87712.1 - 0.023 14.7 0.0 0.11 12.5 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EAK87712.1 - 0.026 14.3 0.0 0.026 14.3 0.0 4.3 3 1 0 3 3 2 0 AAA domain ABC_tran PF00005.27 EAK87712.1 - 0.029 14.9 0.0 0.029 14.9 0.0 4.2 4 1 0 4 4 3 0 ABC transporter AAA_28 PF13521.6 EAK87712.1 - 0.044 14.0 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EAK87712.1 - 0.056 13.8 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EAK87712.1 - 0.068 13.2 0.1 0.37 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EAK87712.1 - 0.087 12.7 0.1 0.52 10.2 0.0 2.1 1 1 1 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EAK87712.1 - 0.1 12.1 0.8 0.5 9.8 0.0 2.5 3 0 0 3 3 2 0 P-loop containing dynein motor region TsaE PF02367.17 EAK87712.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EAK87713.1 - 1.9e-18 67.3 0.0 3.3e-09 37.4 0.0 3.0 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EAK87713.1 - 3.3e-07 30.0 1.2 7.7e-05 22.3 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EAK87713.1 - 0.00021 21.2 3.7 0.017 14.9 0.6 3.9 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system NTPase_1 PF03266.15 EAK87713.1 - 0.058 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 NTPase AAA_16 PF13191.6 EAK87713.1 - 0.11 12.9 0.2 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EAK87713.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EAK87713.1 - 0.2 11.8 0.9 0.51 10.4 0.1 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 EAK87713.1 - 3.2 7.8 7.8 0.28 11.2 0.6 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain Bromodomain PF00439.25 EAK87714.1 - 4.9e-21 74.6 16.3 1.2e-15 57.3 0.5 3.9 3 1 0 3 3 3 2 Bromodomain T5orf172 PF10544.9 EAK87714.1 - 1.6 9.3 7.1 0.78 10.3 0.1 3.2 2 1 0 2 2 2 0 T5orf172 domain FAD_binding_1 PF00667.20 EAK87715.1 - 6.5e-30 104.4 2.3 1.8e-28 99.6 0.9 3.0 2 1 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 EAK87715.1 - 2.7e-11 43.8 0.0 9.1e-10 38.9 0.0 2.3 1 1 0 1 1 1 1 Flavodoxin NAD_binding_6 PF08030.12 EAK87715.1 - 0.00012 22.2 0.1 0.00012 22.2 0.1 2.7 3 0 0 3 3 3 1 Ferric reductase NAD binding domain Rtf2 PF04641.12 EAK87716.1 - 6.9e-12 45.3 0.1 8.1e-12 45.1 0.1 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger tRNA_int_endo PF01974.17 EAK87718.1 - 1.3e-19 70.0 2.6 4.8e-19 68.2 2.6 1.8 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Radical_SAM PF04055.21 EAK87719.1 - 4.5e-09 36.9 0.4 1.8e-07 31.7 0.0 3.3 2 1 1 3 3 3 1 Radical SAM superfamily WD40 PF00400.32 EAK87720.1 - 4.6e-14 52.6 0.3 0.0022 18.8 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK87720.1 - 5.5e-09 36.2 0.1 0.33 11.3 0.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 EAK87720.1 - 0.015 14.6 0.1 0.056 12.7 0.1 2.0 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus zf-met2 PF12907.7 EAK87721.1 - 1.8e-14 53.6 6.5 2.5e-14 53.1 6.5 1.2 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 EAK87721.1 - 1.4e-11 45.1 1.9 1.9e-11 44.6 1.9 1.2 1 0 0 1 1 1 1 4F5 protein family zf-C2H2_12 PF18658.1 EAK87721.1 - 0.049 13.2 1.2 0.071 12.7 1.2 1.3 1 0 0 1 1 1 0 Zinc-finger C2H2-type Elf1 PF05129.13 EAK87721.1 - 0.049 13.7 4.3 0.087 12.9 4.3 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like ASF1_hist_chap PF04729.13 EAK87722.1 - 5e-64 214.9 0.0 7.1e-64 214.4 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone NAP PF00956.18 EAK87723.1 - 6.4e-60 202.6 10.7 6.4e-60 202.6 10.7 2.7 2 1 0 2 2 2 1 Nucleosome assembly protein (NAP) AF-4 PF05110.13 EAK87723.1 - 2.5 6.1 16.7 4.7 5.2 16.7 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DNA_pol_phi PF04931.13 EAK87723.1 - 3.6 5.6 18.1 6.7 4.7 18.1 1.4 1 0 0 1 1 1 0 DNA polymerase phi UQ_con PF00179.26 EAK87724.1 - 7.2e-52 174.8 0.0 8.4e-52 174.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EAK87724.1 - 0.00016 21.4 0.0 0.00022 21.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EAK87724.1 - 0.0043 17.3 0.0 0.0056 17.0 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EAK87724.1 - 0.0084 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 UEV domain Sacchrp_dh_NADP PF03435.18 EAK87725.1 - 1e-05 25.8 0.0 2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UPF0113_N PF17833.1 EAK87726.1 - 1.7e-29 102.2 0.3 2.6e-29 101.6 0.3 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EAK87726.1 - 1.3e-21 76.6 0.0 2.1e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 UPF0113 PUA domain Sortase PF04203.13 EAK87726.1 - 0.019 14.8 0.0 0.052 13.3 0.0 1.7 2 0 0 2 2 2 0 Sortase domain XPA_C PF05181.12 EAK87727.1 - 5.7e-07 29.4 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 XPA protein C-terminus DUF3347 PF11827.8 EAK87727.1 - 0.17 12.1 6.3 0.24 11.6 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) MICSWaP PF17018.5 EAK87727.1 - 2 7.9 6.0 0.75 9.3 1.3 2.0 1 1 1 2 2 2 0 Spore wall protein zf-CCHC_2 PF13696.6 EAK87727.1 - 7 6.6 8.3 3 7.8 0.8 2.4 2 0 0 2 2 2 0 Zinc knuckle Ribosomal_L18 PF17135.4 EAK87728.1 - 1.8e-78 262.2 4.0 2e-78 262.1 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EAK87728.1 - 5.3e-05 23.9 0.1 0.00044 20.9 0.1 2.1 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A UPF0016 PF01169.19 EAK87729.1 - 4e-43 145.6 13.5 2.3e-22 79.1 1.1 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DoxX_2 PF13564.6 EAK87729.1 - 0.068 13.3 0.1 0.068 13.3 0.1 1.8 2 0 0 2 2 2 0 DoxX-like family FTR1 PF03239.14 EAK87729.1 - 2.6 7.1 10.2 0.027 13.6 0.8 2.0 2 0 0 2 2 2 0 Iron permease FTR1 family CDP-OH_P_transf PF01066.21 EAK87730.1 - 2.2e-13 50.7 0.1 2.2e-13 50.7 0.1 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase zf-C2H2_7 PF15269.6 EAK87730.1 - 0.046 13.8 0.7 0.17 12.0 0.7 2.0 1 0 0 1 1 1 0 Zinc-finger DUF2628 PF10947.8 EAK87730.1 - 3.2 8.2 10.8 0.16 12.4 1.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2628) B56 PF01603.20 EAK87731.1 - 5.6e-166 552.6 15.2 7.6e-166 552.2 15.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) ECD PF18432.1 EAK87731.1 - 0.11 12.4 0.2 0.36 10.8 0.0 1.9 2 0 0 2 2 2 0 Extracellular Cadherin domain APAF1_C PF17908.1 EAK87731.1 - 0.12 12.4 1.5 3.5 7.6 0.2 2.9 2 0 0 2 2 2 0 APAF-1 helical domain Proteasome PF00227.26 EAK87732.1 - 1e-57 194.7 0.0 1.4e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EAK87732.1 - 2.1e-13 49.7 0.2 3.7e-13 48.9 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature UQ_con PF00179.26 EAK87733.1 - 1.2e-41 141.7 0.0 1.7e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EAK87733.1 - 1.1e-05 25.2 0.0 2.7e-05 23.9 0.0 1.6 1 1 1 2 2 2 1 Prokaryotic E2 family B UBA PF00627.31 EAK87733.1 - 1.5e-05 24.8 0.1 3.1e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain RWD PF05773.22 EAK87733.1 - 0.0035 17.6 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 RWD domain UBA_3 PF09288.10 EAK87733.1 - 0.0038 17.0 0.5 0.016 15.0 0.5 2.0 1 1 0 1 1 1 1 Fungal ubiquitin-associated domain UBA_4 PF14555.6 EAK87733.1 - 0.021 14.7 0.7 0.048 13.5 0.8 1.6 1 1 0 1 1 1 0 UBA-like domain UEV PF05743.13 EAK87733.1 - 0.044 13.7 0.2 0.092 12.6 0.2 1.5 1 1 0 1 1 1 0 UEV domain E3_UbLigase_EDD PF11547.8 EAK87733.1 - 0.072 12.8 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD Nop PF01798.18 EAK87734.1 - 2.9e-59 200.3 1.2 4.7e-59 199.7 1.2 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EAK87734.1 - 1.6e-26 93.5 1.5 3.4e-26 92.5 1.5 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain KH_1 PF00013.29 EAK87734.1 - 4 7.3 7.9 0.28 11.0 2.0 2.2 2 0 0 2 2 2 0 KH domain CAF1C_H4-bd PF12265.8 EAK87735.1 - 7.4e-11 42.1 0.2 4.2e-10 39.7 0.1 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EAK87735.1 - 0.0058 17.4 13.7 1.3 10.1 0.2 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Ephrin_rec_like PF07699.13 EAK87736.1 - 0.06 13.1 29.5 0.043 13.6 5.6 4.1 2 2 1 3 3 3 0 Putative ephrin-receptor like zf-CHY PF05495.12 EAK87736.1 - 5.9 7.5 12.3 5.8 7.5 2.4 2.9 2 1 0 2 2 2 0 CHY zinc finger PMM PF03332.13 EAK87737.1 - 4.6e-99 330.7 2.5 5.7e-99 330.4 2.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EAK87737.1 - 2.3e-09 37.4 0.1 1.5e-08 34.7 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EAK87737.1 - 7.7e-05 22.3 0.0 0.054 13.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EAK87737.1 - 0.058 13.7 0.1 0.55 10.5 0.2 2.0 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EAK87737.1 - 0.32 11.1 2.8 3 7.9 0.1 2.6 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase FOG_N PF15888.5 EAK87738.1 - 9.4 6.7 42.8 3.6 8.0 0.2 10.1 5 4 5 10 10 10 0 Folded gastrulation N-terminus RPA_C PF08784.11 EAK87739.1 - 0.011 16.4 1.1 0.021 15.5 1.1 1.5 1 0 0 1 1 1 0 Replication protein A C terminal tRNA_bind PF01588.20 EAK87740.1 - 1.1e-26 92.7 0.0 2.5e-26 91.6 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.6 EAK87740.1 - 0.00014 21.9 0.0 0.0003 20.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EAK87740.1 - 0.0033 17.2 0.0 0.0064 16.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EAK87740.1 - 0.04 14.2 0.0 0.089 13.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EAK87740.1 - 0.079 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GCV_T PF01571.21 EAK87741.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain V-SNARE_C PF12352.8 EAK87742.1 - 5.9e-08 32.9 1.6 1.5e-07 31.6 1.6 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DHO_dh PF01180.21 EAK87742.1 - 0.18 11.0 1.4 0.26 10.4 1.4 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Lipase_GDSL_3 PF14606.6 EAK87742.1 - 0.3 11.2 4.8 0.18 11.9 2.2 1.8 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Sec20 PF03908.13 EAK87742.1 - 5.1 7.1 16.5 0.14 12.1 4.5 2.9 2 1 2 4 4 4 0 Sec20 Thioredoxin_13 PF18401.1 EAK87743.1 - 3.5e-05 23.7 0.1 0.00018 21.4 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain MRP-S33 PF08293.11 EAK87743.1 - 0.085 13.1 0.2 1.1 9.5 0.0 3.1 2 1 1 3 3 3 0 Mitochondrial ribosomal subunit S27 eIF-3c_N PF05470.12 EAK87744.1 - 1.2e-118 397.0 20.8 3.9e-66 223.6 2.3 2.5 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EAK87744.1 - 3.6e-09 37.1 1.2 1.5e-08 35.1 0.3 2.6 2 0 0 2 2 2 1 PCI domain ANAPC3 PF12895.7 EAK87744.1 - 0.043 14.1 0.0 24 5.3 0.0 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Baculo_PEP_C PF04513.12 EAK87745.1 - 0.12 12.4 0.7 0.3 11.1 0.7 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ank_4 PF13637.6 EAK87746.1 - 1.2e-15 57.6 2.9 1.3e-07 32.0 0.1 5.8 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAK87746.1 - 8.6e-11 42.3 0.9 2e-06 28.3 0.3 4.8 3 2 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EAK87746.1 - 7e-06 26.0 8.5 1.4 9.7 0.0 6.9 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EAK87746.1 - 0.0034 17.6 1.9 0.96 9.9 0.1 4.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAK87747.1 - 2e-22 79.5 0.0 1.7e-14 54.1 0.0 4.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK87747.1 - 7.3e-16 58.3 0.7 1e-06 29.2 0.0 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EAK87747.1 - 6.3e-14 51.7 0.2 7.5e-05 23.0 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EAK87747.1 - 1.4e-13 49.6 1.4 0.0013 19.1 0.0 5.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EAK87747.1 - 4e-13 49.3 0.1 9.1e-08 32.2 0.0 4.4 4 1 1 5 5 5 2 Ankyrin repeats (many copies) AP2 PF00847.20 EAK87748.1 - 0.0091 16.2 0.9 0.0091 16.2 0.9 2.5 2 0 0 2 2 2 1 AP2 domain TFIIE_alpha PF02002.17 EAK87749.1 - 0.00029 20.7 0.1 0.0024 17.7 0.1 2.4 2 0 0 2 2 2 1 TFIIE alpha subunit HTH_Mga PF08280.11 EAK87749.1 - 0.0042 17.1 3.1 0.02 14.9 0.1 3.0 3 0 0 3 3 3 1 M protein trans-acting positive regulator (MGA) HTH domain GntR PF00392.21 EAK87749.1 - 0.0095 15.6 1.4 0.011 15.3 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 EAK87749.1 - 0.011 15.7 0.1 0.027 14.4 0.1 1.7 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 EAK87749.1 - 0.017 14.6 0.1 0.053 13.1 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TFIIE-A_C PF11521.8 EAK87749.1 - 0.16 12.3 0.2 0.16 12.3 0.2 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Methyltransf_8 PF05148.15 EAK87750.1 - 6e-53 179.9 1.5 2.7e-52 177.8 0.1 2.0 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EAK87750.1 - 5.9e-05 23.6 0.0 0.00012 22.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK87750.1 - 0.0066 16.3 2.5 0.045 13.5 2.5 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAK87750.1 - 0.011 16.4 0.0 0.031 15.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EAK87750.1 - 0.051 13.4 0.0 0.23 11.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain APP_E2 PF12925.7 EAK87752.1 - 0.02 14.6 2.7 0.99 9.1 0.0 2.4 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein HWE_HK PF07536.14 EAK87752.1 - 0.024 15.3 0.2 12 6.7 0.0 2.9 2 0 0 2 2 2 0 HWE histidine kinase Col_cuticle_N PF01484.17 EAK87752.1 - 0.03 14.4 0.2 6.8 6.8 0.1 3.3 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain LIF_OSM PF01291.17 EAK87752.1 - 0.34 11.1 2.7 0.66 10.1 1.2 2.1 2 0 0 2 2 2 0 LIF / OSM family Pkinase PF00069.25 EAK87754.1 - 1.4e-31 109.8 0.5 3.5e-14 52.8 0.0 3.7 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EAK87754.1 - 5.3e-10 39.0 0.0 3.1e-05 23.4 0.0 3.6 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EAK87754.1 - 0.00082 18.8 0.2 2.7 7.3 0.0 3.7 4 0 0 4 4 4 1 Kinase-like FTA2 PF13095.6 EAK87754.1 - 0.0077 15.9 0.1 0.49 10.0 0.1 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EAK87754.1 - 0.091 11.5 0.0 0.091 11.5 0.0 2.6 3 0 0 3 3 3 0 Fungal protein kinase Cwf_Cwc_15 PF04889.12 EAK87754.1 - 0.93 9.2 9.2 0.072 12.8 3.2 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein BCNT PF07572.12 EAK87755.1 - 4.3e-17 61.9 2.6 4.3e-17 61.9 2.6 1.5 2 0 0 2 2 2 1 Bucentaur or craniofacial development MTS PF05175.14 EAK87756.1 - 3.6e-08 33.2 0.0 5.7e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EAK87756.1 - 0.00018 21.3 0.0 0.00025 20.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EAK87756.1 - 0.00068 19.5 0.0 0.00096 19.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain rRNA_methylase PF06962.12 EAK87756.1 - 0.0031 17.5 0.0 0.0065 16.5 0.0 1.4 1 0 0 1 1 1 1 Putative rRNA methylase Methyltransf_18 PF12847.7 EAK87756.1 - 0.01 15.8 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EAK87756.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TRM13 PF05206.14 EAK87756.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TRM13 Methyltransf_25 PF13649.6 EAK87756.1 - 0.019 15.6 0.0 0.041 14.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 EAK87756.1 - 0.037 13.7 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.6 EAK87756.1 - 0.038 15.0 0.0 0.081 14.0 0.0 1.5 2 0 0 2 2 1 0 Methyltransferase domain N6_Mtase PF02384.16 EAK87756.1 - 0.062 12.6 0.0 0.36 10.1 0.0 1.9 2 0 0 2 2 2 0 N-6 DNA Methylase PRMT5 PF05185.16 EAK87756.1 - 0.064 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Cons_hypoth95 PF03602.15 EAK87756.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_10 PF05971.12 EAK87756.1 - 0.14 11.4 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 RNA methyltransferase Methyltransf_33 PF10017.9 EAK87756.1 - 0.18 10.9 0.1 0.62 9.2 0.0 1.9 3 0 0 3 3 3 0 Histidine-specific methyltransferase, SAM-dependent PRTP PF01366.18 EAK87757.1 - 0.022 12.8 0.4 0.031 12.4 0.4 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Nudc_N PF14050.6 EAK87757.1 - 0.052 13.5 0.3 0.12 12.4 0.3 1.6 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. DUF4471 PF14740.6 EAK87758.1 - 0.016 14.4 0.9 0.017 14.4 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) RNA_pol_Rpo13 PF12136.8 EAK87758.1 - 0.043 13.7 11.9 0.081 12.8 11.9 1.5 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain Phosducin PF02114.16 EAK87758.1 - 0.12 11.3 5.6 0.15 10.9 5.6 1.1 1 0 0 1 1 1 0 Phosducin Collagen PF01391.18 EAK87759.1 - 0.0058 16.4 38.0 2.9e+02 1.3 33.0 3.2 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) DASH_Dad4 PF08650.10 EAK87759.1 - 2.4 8.2 8.9 4.3 7.4 0.5 2.7 3 0 0 3 3 3 0 DASH complex subunit Dad4 V-ATPase_H_C PF11698.8 EAK87760.1 - 0.0017 18.4 1.2 0.035 14.2 0.1 2.8 3 0 0 3 3 3 1 V-ATPase subunit H DUF2913 PF11140.8 EAK87760.1 - 0.01 15.6 2.5 0.011 15.5 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) V-SNARE_C PF12352.8 EAK87760.1 - 0.045 14.0 0.8 0.18 12.1 0.8 2.1 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Zemlya PF17646.1 EAK87760.1 - 0.08 13.3 1.7 0.29 11.5 0.8 2.3 2 1 0 2 2 2 0 Closterovirus 1a polyprotein central region NOA36 PF06524.12 EAK87761.1 - 6.4 6.0 13.2 14 4.9 13.2 1.5 1 0 0 1 1 1 0 NOA36 protein PMG PF05287.12 EAK87762.1 - 0.0025 17.9 2.6 0.0036 17.3 2.6 1.2 1 0 0 1 1 1 1 PMG protein Allexi_40kDa PF05549.11 EAK87762.1 - 0.035 13.6 6.1 0.042 13.3 5.8 1.3 1 1 0 1 1 1 0 Allexivirus 40kDa protein ParcG PF10274.9 EAK87762.1 - 0.041 14.0 0.7 4.4 7.4 0.1 2.3 1 1 0 2 2 2 0 Parkin co-regulated protein SIR2 PF02146.17 EAK87762.1 - 0.11 12.5 2.5 0.19 11.6 0.8 1.8 1 1 0 2 2 2 0 Sir2 family Thioredoxin_16 PF18569.1 EAK87762.1 - 0.14 12.3 0.5 0.14 12.3 0.5 2.0 2 1 0 2 2 2 0 Thioredoxin-like domain Noelin-1 PF12308.8 EAK87762.1 - 0.58 10.2 4.8 0.98 9.4 2.0 2.1 2 0 0 2 2 2 0 Neurogenesis glycoprotein ARD PF03079.14 EAK87765.1 - 0.27 11.4 0.0 0.27 11.4 0.0 2.3 3 0 0 3 3 3 0 ARD/ARD' family TrbM PF07424.11 EAK87766.1 - 0.001 19.1 1.1 0.0067 16.4 0.1 2.4 2 0 0 2 2 2 1 TrbM BioT2 PF15368.6 EAK87766.1 - 0.023 14.7 0.1 0.061 13.3 0.1 1.7 1 0 0 1 1 1 0 Spermatogenesis family BioT2 Viral_Beta_CD PF04530.12 EAK87767.1 - 0.022 15.1 1.4 1.4 9.2 0.2 2.8 2 0 0 2 2 2 0 Viral Beta C/D like family Helicase_C PF00271.31 EAK87767.1 - 0.25 11.7 1.6 1.4 9.3 0.3 3.0 2 1 0 2 2 2 0 Helicase conserved C-terminal domain HOK_GEF PF01848.16 EAK87769.1 - 0.063 12.7 0.3 0.14 11.6 0.3 1.5 1 0 0 1 1 1 0 Hok/gef family PV-1 PF06637.11 EAK87769.1 - 0.094 11.5 1.3 0.17 10.6 0.4 1.7 2 0 0 2 2 2 0 PV-1 protein (PLVAP) Kazal_1 PF00050.21 EAK87770.1 - 6.8e-75 246.9 122.7 8.7e-10 38.5 5.0 13.1 13 0 0 13 13 13 12 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EAK87770.1 - 9.8e-73 240.1 133.4 6.1e-10 39.1 6.4 13.0 13 0 0 13 13 13 12 Kazal-type serine protease inhibitor domain SSP160 PF06933.11 EAK87770.1 - 0.15 10.2 12.5 0.43 8.7 12.5 1.7 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Tower PF09121.10 EAK87770.1 - 0.22 11.7 0.1 52 4.1 0.0 4.2 5 0 0 5 5 5 0 Tower FSA_C PF10479.9 EAK87770.1 - 4.5 5.3 9.8 0.013 13.6 0.4 1.4 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus LPD5 PF18799.1 EAK87771.1 - 2.8 8.3 10.7 0.66 10.4 0.1 3.1 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 5 Tox-ART-HYD1 PF15633.6 EAK87772.1 - 0.046 14.4 0.2 0.08 13.6 0.2 1.4 1 0 0 1 1 1 0 HYD1 signature containing ADP-ribosyltransferase Sulfotransfer_3 PF13469.6 EAK87772.1 - 0.15 12.4 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family DUF1465 PF07323.12 EAK87775.1 - 0.029 14.2 0.4 0.029 14.2 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) RcbX PF02341.15 EAK87775.1 - 0.14 12.4 1.4 2.9 8.2 0.1 3.1 2 0 0 2 2 2 0 RbcX protein DUF2935 PF11155.8 EAK87775.1 - 0.47 10.8 2.9 6.2 7.2 0.5 3.8 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF4596 PF15363.6 EAK87775.1 - 0.64 10.3 4.0 7.3 6.9 4.0 3.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4596) DUF4227 PF14004.6 EAK87778.1 - 0.55 10.2 4.5 1.5 8.9 4.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) DUF1108 PF06531.11 EAK87779.1 - 0.025 14.9 0.8 0.08 13.3 0.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) ASFV_J13L PF05568.11 EAK87779.1 - 0.096 12.4 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein ACDC PF14733.6 EAK87781.1 - 0.15 12.4 0.0 0.45 10.9 0.0 1.8 1 0 0 1 1 1 0 AP2-coincident C-terminal PGA2 PF07543.12 EAK87782.1 - 0.12 12.4 11.4 0.41 10.6 0.2 3.4 3 0 0 3 3 3 0 Protein trafficking PGA2 Helicase_Sgs1 PF11408.8 EAK87782.1 - 0.27 11.3 10.6 0.1 12.6 0.6 3.8 3 0 0 3 3 3 0 Sgs1 RecQ helicase Vps53_N PF04100.12 EAK87783.1 - 8.1e-19 67.8 27.0 7.2e-13 48.2 6.7 4.1 2 1 0 2 2 2 2 Vps53-like, N-terminal DNA_meth_N PF18284.1 EAK87783.1 - 0.16 11.9 0.2 5.7 6.9 0.0 2.7 2 0 0 2 2 2 0 DNA methylase N-terminal domain PFK PF00365.20 EAK87784.1 - 0.0046 16.3 1.4 0.015 14.6 1.4 1.8 1 0 0 1 1 1 1 Phosphofructokinase Serglycin PF04360.12 EAK87784.1 - 0.008 16.1 3.5 0.013 15.5 1.1 2.6 2 0 0 2 2 2 1 Serglycin AMP-binding PF00501.28 EAK87785.1 - 1.8e-74 250.8 0.0 2.6e-74 250.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF643 PF04867.12 EAK87785.1 - 0.0055 17.3 0.1 0.023 15.3 0.1 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF643) ETRAMP PF09716.10 EAK87785.1 - 0.042 13.9 0.8 0.16 12.1 0.8 2.0 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) RSS_P20 PF11757.8 EAK87785.1 - 0.13 12.7 0.0 0.84 10.1 0.0 2.3 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain Beach PF02138.18 EAK87786.1 - 3.5e-78 262.8 4.6 3.5e-78 262.8 4.6 1.8 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 EAK87786.1 - 0.063 13.4 1.7 6.1 7.0 0.4 4.1 2 1 0 2 2 2 0 PH domain associated with Beige/BEACH GATA PF00320.27 EAK87789.1 - 0.23 11.1 7.1 0.16 11.6 0.5 2.4 2 0 0 2 2 2 0 GATA zinc finger PH PF00169.29 EAK87790.1 - 1.4e-12 48.0 0.0 5.6e-11 42.9 0.0 3.1 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 EAK87790.1 - 0.0035 17.6 0.0 0.0086 16.3 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EAK87790.1 - 0.0043 17.3 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain NOC3p PF07540.11 EAK87791.1 - 4e-14 52.8 2.8 5.9e-14 52.3 0.0 2.7 3 0 0 3 3 3 1 Nucleolar complex-associated protein PGM_PMM_I PF02878.16 EAK87792.1 - 5.1e-15 55.4 0.0 1.5e-07 31.2 0.0 2.8 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EAK87792.1 - 5.6e-07 29.6 0.0 2.4e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EAK87792.1 - 9.3e-05 23.0 0.1 0.001 19.6 0.1 2.6 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II IMCp PF12314.8 EAK87793.1 - 1.9e-08 34.5 54.4 8.9e-06 25.9 31.5 3.8 1 1 3 4 4 4 2 Inner membrane complex protein PsbU PF06514.11 EAK87793.1 - 0.076 13.0 0.8 0.18 11.8 0.5 1.8 1 1 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) IMCp PF12314.8 EAK87794.1 - 1.2e-12 47.9 33.9 1.2e-12 47.9 33.9 3.1 2 1 0 2 2 2 1 Inner membrane complex protein DUF2476 PF10630.9 EAK87794.1 - 0.018 15.2 0.3 0.053 13.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2476) NIF PF03031.18 EAK87795.1 - 1.4e-42 145.1 2.5 3.4e-42 143.9 0.5 2.2 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase TRM PF02005.16 EAK87796.1 - 1.9e-93 313.6 6.0 1.9e-66 224.8 3.2 3.5 2 1 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_25 PF13649.6 EAK87796.1 - 0.041 14.6 0.0 0.36 11.6 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain PrmA PF06325.13 EAK87796.1 - 0.097 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Pkinase PF00069.25 EAK87797.1 - 0.0027 17.1 0.7 2 7.7 0.1 2.7 2 0 0 2 2 2 2 Protein kinase domain DUF1957 PF09210.11 EAK87797.1 - 0.15 12.4 1.7 12 6.4 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1957) Telomerase_RBD PF12009.8 EAK87797.1 - 2.5 8.2 6.5 1.6 8.8 0.1 3.1 3 0 0 3 3 3 0 Telomerase ribonucleoprotein complex - RNA binding domain MTH865 PF07747.11 EAK87798.1 - 0.0069 16.1 0.0 0.02 14.7 0.0 1.8 2 0 0 2 2 2 1 MTH865-like family Ribosomal_S3Ae PF01015.18 EAK87799.1 - 2.2e-87 291.8 1.3 2.7e-87 291.6 1.3 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 EAK87799.1 - 0.024 14.2 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region SUI1 PF01253.22 EAK87799.1 - 1.4 9.5 5.1 7 7.3 0.0 2.8 3 0 0 3 3 3 0 Translation initiation factor SUI1 Cullin PF00888.22 EAK87800.1 - 1.1e-115 387.6 24.3 1.5e-115 387.2 24.3 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EAK87800.1 - 2.1e-13 50.1 2.5 2.1e-13 50.1 2.5 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain SRI PF08236.11 EAK87800.1 - 0.015 15.4 0.1 0.29 11.3 0.1 3.1 1 1 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain TPT PF03151.16 EAK87801.1 - 1.5e-24 86.9 12.5 1.5e-24 86.9 12.5 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EAK87801.1 - 5.3e-08 33.1 27.1 0.00014 22.0 9.8 3.1 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 EAK87801.1 - 3.1e-05 23.3 15.4 5.7e-05 22.5 15.4 1.4 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 EAK87801.1 - 3.4e-05 23.2 10.7 0.0018 17.5 10.7 2.5 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 EAK87801.1 - 0.0069 15.9 8.8 0.018 14.6 0.7 2.5 3 0 0 3 3 3 2 Solute carrier family 35 TMEM234 PF10639.9 EAK87801.1 - 0.014 15.4 1.4 0.014 15.4 1.4 2.1 2 0 0 2 2 2 0 Putative transmembrane family 234 eIF-6 PF01912.18 EAK87802.1 - 3.1e-77 258.4 2.2 4e-77 258.1 1.7 1.4 1 1 0 1 1 1 1 eIF-6 family Guanylate_cyc PF00211.20 EAK87803.1 - 9.2e-17 61.2 0.0 3.5e-08 33.3 0.0 3.2 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain EB PF01683.18 EAK87804.1 - 3.9e-05 23.8 41.6 0.2 12.0 1.1 10.6 6 4 2 8 8 8 4 EB module FOG_N PF15888.5 EAK87804.1 - 0.0051 17.2 41.6 1.1 9.6 0.1 11.0 3 3 9 14 14 14 3 Folded gastrulation N-terminus Prok-E2_C PF14459.6 EAK87804.1 - 0.48 10.6 4.6 3.1 8.0 0.0 4.1 1 1 3 5 5 5 0 Prokaryotic E2 family C Antistasin PF02822.14 EAK87804.1 - 4.8 7.9 64.4 16 6.2 0.7 14.5 9 5 4 13 13 13 0 Antistasin family FAM176 PF14851.6 EAK87805.1 - 0.0085 15.8 2.3 0.029 14.0 2.3 1.8 1 1 0 1 1 1 1 FAM176 family Herpes_glycop PF01528.16 EAK87805.1 - 0.013 14.4 0.0 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M PROL5-SMR PF15621.6 EAK87805.1 - 0.018 15.5 0.1 0.047 14.2 0.1 1.8 1 1 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family Shisa PF13908.6 EAK87805.1 - 0.029 14.6 5.9 0.047 13.9 5.9 1.5 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Polysacc_synt PF01943.17 EAK87805.1 - 0.04 13.3 0.0 0.051 13.0 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RIC3 PF15361.6 EAK87805.1 - 0.05 14.0 0.1 0.05 14.0 0.1 2.2 1 1 1 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DUF4407 PF14362.6 EAK87805.1 - 0.068 12.5 1.2 0.086 12.2 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 EAK87805.1 - 0.098 10.8 7.6 0.1 10.7 7.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 EAK87805.1 - 0.14 10.9 8.6 0.17 10.6 8.6 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EAK87805.1 - 0.15 11.1 6.8 0.16 10.9 6.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Mem_trans PF03547.18 EAK87805.1 - 0.2 10.0 1.7 0.23 9.8 1.7 1.1 1 0 0 1 1 1 0 Membrane transport protein Neur_chan_memb PF02932.16 EAK87805.1 - 0.39 10.7 4.7 0.48 10.5 4.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region OAD_gamma PF04277.13 EAK87805.1 - 1.3 9.6 9.8 38 5.0 9.8 2.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4834 PF16118.5 EAK87805.1 - 3.1 8.8 15.8 7.5e+02 1.2 15.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Otopetrin PF03189.13 EAK87805.1 - 3.9 6.2 5.4 4.9 5.9 5.4 1.3 1 1 0 1 1 1 0 Otopetrin Kei1 PF08552.11 EAK87805.1 - 6.1 6.7 8.5 33 4.3 8.5 1.9 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Borrelia_P83 PF05262.11 EAK87805.1 - 6.1 5.2 15.6 7.1 5.0 15.6 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Abhydrolase_2 PF02230.16 EAK87807.1 - 2.4e-06 27.5 0.1 6.9e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 EAK87807.1 - 0.091 12.4 0.0 0.61 9.7 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Aminotran_5 PF00266.19 EAK87808.1 - 3.2e-81 273.2 0.0 3.7e-81 272.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EAK87808.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EAK87808.1 - 0.022 14.0 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Abhydrolase_2 PF02230.16 EAK87809.1 - 1.9e-07 31.1 0.0 3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 EAK87809.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Glyco_hydro_42C PF08533.10 EAK87810.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain UXS1_N PF11803.8 EAK87811.1 - 0.00088 19.6 0.9 0.029 14.7 0.0 2.7 2 1 1 3 3 3 1 UDP-glucuronate decarboxylase N-terminal Tropomyosin PF00261.20 EAK87811.1 - 0.0035 16.7 9.5 0.0075 15.7 8.5 1.8 1 1 1 2 2 2 1 Tropomyosin SlyX PF04102.12 EAK87811.1 - 0.0071 16.9 2.3 0.49 11.1 0.3 3.2 3 1 1 4 4 4 2 SlyX BLOC1_2 PF10046.9 EAK87811.1 - 0.011 16.0 0.7 0.011 16.0 0.7 3.8 2 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ING PF12998.7 EAK87811.1 - 0.031 14.8 4.1 0.031 14.8 4.1 2.8 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding FAS_N PF17828.1 EAK87811.1 - 0.07 13.1 3.5 0.26 11.3 0.6 2.8 2 1 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta Atg14 PF10186.9 EAK87811.1 - 0.099 11.7 8.2 0.11 11.5 7.5 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF16 PF01519.16 EAK87811.1 - 0.13 12.7 12.9 1.2 9.7 8.7 3.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 Imm44 PF15571.6 EAK87811.1 - 0.15 12.3 0.3 0.15 12.3 0.3 3.2 1 1 3 4 4 4 0 Immunity protein 44 ATG16 PF08614.11 EAK87811.1 - 0.3 11.3 6.6 0.32 11.2 3.4 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CLZ PF16526.5 EAK87811.1 - 0.41 11.1 7.3 3.2 8.2 0.3 3.9 3 1 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 EAK87811.1 - 0.48 10.6 19.4 0.68 10.1 7.8 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EAK87811.1 - 0.7 10.3 10.3 0.23 11.9 4.0 2.3 1 1 2 3 3 3 0 Fez1 TMPIT PF07851.13 EAK87811.1 - 0.89 8.7 13.5 3.4 6.8 0.5 3.0 2 1 1 3 3 3 0 TMPIT-like protein Noelin-1 PF12308.8 EAK87811.1 - 1 9.4 5.3 0.28 11.2 1.0 2.3 2 1 0 2 2 2 0 Neurogenesis glycoprotein Prefoldin PF02996.17 EAK87811.1 - 1.1 9.1 11.7 9.6 6.1 0.6 4.6 3 1 2 5 5 5 0 Prefoldin subunit DUF641 PF04859.12 EAK87811.1 - 1.7 9.0 8.4 11 6.4 3.0 3.1 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Laminin_II PF06009.12 EAK87811.1 - 1.7 8.7 12.0 0.46 10.5 3.3 2.8 2 1 1 3 3 3 0 Laminin Domain II OmpH PF03938.14 EAK87811.1 - 2.3 8.5 7.2 13 6.1 5.9 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) AKNA PF12443.8 EAK87811.1 - 2.8 8.7 5.1 4.9 7.9 0.1 3.3 2 1 2 4 4 4 0 AT-hook-containing transcription factor DUF1664 PF07889.12 EAK87811.1 - 3.2 7.8 10.2 38 4.4 0.6 3.3 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 EAK87811.1 - 3.6 7.1 10.4 2.2 7.8 1.1 3.2 3 1 0 3 3 3 0 fzo-like conserved region Uso1_p115_C PF04871.13 EAK87811.1 - 5.5 7.4 12.2 8.9 6.7 2.8 3.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4200 PF13863.6 EAK87811.1 - 8.5 6.8 15.6 0.96 9.9 0.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DEAD PF00270.29 EAK87812.1 - 1.1e-49 168.6 0.0 1.8e-49 167.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87812.1 - 1.5e-32 112.3 0.0 7e-32 110.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK87812.1 - 0.044 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EAK87812.1 - 0.14 12.5 0.1 3.6 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain Tti2 PF10521.9 EAK87812.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Tti2 family AP2 PF00847.20 EAK87814.1 - 1e-05 25.7 4.8 1e-05 25.7 0.4 2.5 1 1 1 2 2 2 1 AP2 domain Ribosomal_S30 PF04758.14 EAK87814.1 - 0.081 13.1 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S30 Fis1_TPR_C PF14853.6 EAK87815.1 - 2.8e-09 36.9 4.4 0.00019 21.5 1.0 2.6 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 EAK87815.1 - 2.4e-08 33.4 5.4 0.00013 21.8 0.6 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EAK87815.1 - 1.4e-07 31.0 11.7 0.00068 19.4 1.6 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK87815.1 - 4.5e-05 23.6 4.8 6.5e-05 23.1 4.8 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EAK87815.1 - 0.00014 22.3 0.2 0.00036 21.0 0.2 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat DUF3856 PF12968.7 EAK87815.1 - 0.0028 17.7 0.5 0.46 10.6 0.1 2.1 1 1 1 2 2 2 2 Domain of Unknown Function (DUF3856) TPR_8 PF13181.6 EAK87815.1 - 0.0087 16.2 6.3 0.01 16.0 0.6 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EAK87815.1 - 0.0093 16.2 0.8 0.033 14.5 0.5 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF3973 PF13119.6 EAK87815.1 - 0.031 14.4 0.1 0.084 13.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3973) TPR_7 PF13176.6 EAK87815.1 - 0.071 13.2 0.1 0.29 11.3 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Caud_tail_N PF16838.5 EAK87815.1 - 0.079 13.4 0.3 0.19 12.2 0.0 1.7 2 0 0 2 2 2 0 Caudoviral major tail protein N-terminus Vps52 PF04129.12 EAK87816.1 - 3.4e-08 32.7 21.0 0.00041 19.2 3.6 2.4 2 0 0 2 2 2 2 Vps52 / Sac2 family DivIC PF04977.15 EAK87817.1 - 0.032 14.0 0.1 0.032 14.0 0.1 5.2 5 2 1 6 6 6 0 Septum formation initiator HALZ PF02183.18 EAK87817.1 - 2.4 8.5 16.5 0.18 12.1 2.2 4.8 4 1 0 4 4 4 0 Homeobox associated leucine zipper Stork_head PF10264.9 EAK87818.1 - 0.004 17.3 0.2 0.004 17.3 0.2 3.5 4 1 2 6 6 6 1 Winged helix Storkhead-box1 domain DUF3195 PF11424.8 EAK87818.1 - 0.034 14.2 0.4 0.17 12.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3195) DUF3368 PF11848.8 EAK87818.1 - 0.1 12.4 0.0 0.37 10.6 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) Gag_spuma PF03276.14 EAK87818.1 - 0.19 10.1 0.1 0.28 9.6 0.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Lar_N PF09861.9 EAK87818.1 - 0.63 9.2 5.1 3.9 6.6 0.2 2.7 2 0 0 2 2 2 0 Lactate racemase N-terminal domain ketoacyl-synt PF00109.26 EAK87820.1 - 0 1464.1 0.0 2.8e-69 233.5 0.0 7.3 7 0 0 7 7 7 7 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EAK87820.1 - 3.2e-248 807.7 8.1 1e-39 135.2 0.0 7.5 7 0 0 7 7 7 7 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EAK87820.1 - 1.3e-194 641.0 0.0 1.5e-48 165.1 0.0 7.2 6 0 0 6 6 6 4 KR domain PP-binding PF00550.25 EAK87820.1 - 4.8e-99 324.8 15.7 1.7e-13 50.7 0.1 8.8 8 0 0 8 8 8 8 Phosphopantetheine attachment site Acyl_transf_1 PF00698.21 EAK87820.1 - 1.4e-75 254.8 0.0 5.5e-44 151.0 0.0 2.3 2 0 0 2 2 2 2 Acyl transferase domain PS-DH PF14765.6 EAK87820.1 - 2.2e-71 240.6 0.0 2.3e-25 89.5 0.0 4.4 4 1 0 4 4 4 4 Polyketide synthase dehydratase NAD_binding_4 PF07993.12 EAK87820.1 - 3.2e-71 239.5 0.0 1.3e-68 231.0 0.0 3.1 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 EAK87820.1 - 1.9e-58 198.1 0.0 8.2e-58 196.0 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme KAsynt_C_assoc PF16197.5 EAK87820.1 - 1.3e-43 148.0 18.9 5.8e-06 26.7 0.3 8.2 7 0 0 7 7 7 7 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EAK87820.1 - 1.3e-38 131.9 0.0 2.1e-12 47.2 0.0 3.8 3 0 0 3 3 3 3 Zinc-binding dehydrogenase adh_short PF00106.25 EAK87820.1 - 2.5e-30 105.4 14.2 9e-08 31.8 0.2 7.6 9 0 0 9 9 8 4 short chain dehydrogenase Thiolase_N PF00108.23 EAK87820.1 - 4e-23 82.1 16.3 0.0089 15.4 0.0 7.4 7 0 0 7 7 7 6 Thiolase, N-terminal domain ADH_zinc_N_2 PF13602.6 EAK87820.1 - 5.1e-20 72.9 0.0 1.3e-08 35.9 0.0 3.8 3 0 0 3 3 3 3 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EAK87820.1 - 6.8e-18 65.1 0.0 0.0055 16.3 0.0 5.2 5 0 0 5 5 5 4 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EAK87820.1 - 1.3e-16 60.5 5.1 2.7e-05 24.0 0.0 5.0 4 0 0 4 4 4 3 Alcohol dehydrogenase GroES-like domain GDP_Man_Dehyd PF16363.5 EAK87820.1 - 4.5e-13 49.3 5.3 0.0059 16.1 0.1 5.0 5 0 0 5 5 5 3 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EAK87820.1 - 4.1e-07 29.7 0.0 5 6.5 0.0 5.6 6 0 0 6 6 6 3 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EAK87820.1 - 2.7e-06 26.8 7.9 0.073 12.2 0.0 5.2 5 0 0 5 5 5 2 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EAK87820.1 - 4.2e-06 27.0 0.6 11 6.2 0.0 6.7 8 0 0 8 8 6 0 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EAK87820.1 - 0.00044 19.6 0.2 0.25 10.6 0.1 2.7 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain SAT PF16073.5 EAK87820.1 - 0.007 16.1 0.0 0.045 13.5 0.0 2.1 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis AMP-binding_C_2 PF14535.6 EAK87820.1 - 0.043 14.1 0.2 0.25 11.7 0.2 2.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Sugar_tr PF00083.24 EAK87821.1 - 3.2e-22 79.0 44.4 1e-14 54.3 15.0 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EAK87821.1 - 3.5e-08 32.8 45.0 4.4e-05 22.6 11.9 3.5 2 2 1 3 3 3 2 Major Facilitator Superfamily DUF3314 PF11771.8 EAK87823.1 - 0.15 12.2 1.8 0.29 11.3 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3314) GIDA PF01134.22 EAK87823.1 - 0.17 10.9 8.7 0.21 10.6 8.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Cellulose_synt PF03552.14 EAK87823.1 - 0.33 9.4 6.0 0.53 8.7 6.0 1.3 1 0 0 1 1 1 0 Cellulose synthase zf-LITAF-like PF10601.9 EAK87824.1 - 2.8e-14 53.1 4.3 2.8e-14 53.1 4.3 2.4 1 1 1 2 2 2 1 LITAF-like zinc ribbon domain Rubredoxin PF00301.20 EAK87824.1 - 0.045 13.8 1.2 0.15 12.1 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin HypA PF01155.19 EAK87824.1 - 0.34 10.9 5.6 2.6 8.1 5.6 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CDP-OH_P_transf PF01066.21 EAK87826.1 - 1.3e-15 57.9 1.7 1.3e-15 57.9 1.7 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Aa_trans PF01490.18 EAK87827.1 - 5.2e-30 104.5 31.1 6.5e-30 104.1 31.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MOZART1 PF12554.8 EAK87828.1 - 5.1e-18 64.6 2.9 7.1e-18 64.1 2.9 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Imm26 PF15428.6 EAK87829.1 - 0.33 11.2 3.5 0.52 10.6 0.4 3.0 3 0 0 3 3 3 0 Immunity protein 26 WD40 PF00400.32 EAK87830.1 - 3.6e-10 40.3 11.8 0.00016 22.4 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK87830.1 - 2.4e-06 27.8 2.0 2.3e-05 24.6 0.2 3.4 3 2 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EAK87830.1 - 0.0015 17.4 0.2 0.31 9.7 0.0 2.4 1 1 1 2 2 2 2 Nup133 N terminal like Nup160 PF11715.8 EAK87830.1 - 0.018 13.7 0.9 0.15 10.7 0.1 2.4 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Brix PF04427.18 EAK87831.1 - 5.3e-31 108.2 0.1 6.9e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Brix domain E1-E2_ATPase PF00122.20 EAK87832.1 - 1.4e-46 158.3 1.3 3e-46 157.2 0.1 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EAK87832.1 - 2.1e-33 115.6 1.3 2.1e-33 115.6 1.3 3.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EAK87832.1 - 3.1e-22 79.9 0.1 1.6e-16 61.3 0.0 3.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EAK87832.1 - 4.8e-16 58.2 0.1 1.1e-15 57.1 0.1 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EAK87832.1 - 1.9e-08 34.3 4.5 1.6e-07 31.3 2.1 3.4 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EAK87832.1 - 0.0018 18.0 0.5 0.0018 18.0 0.5 2.9 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EAK87832.1 - 0.0038 17.7 0.0 0.036 14.5 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2190 PF09956.9 EAK87832.1 - 0.017 15.6 1.0 0.056 13.9 1.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2190) Flavodoxin_1 PF00258.25 EAK87834.1 - 3.1e-18 66.3 0.0 4.9e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EAK87834.1 - 3.2e-11 43.8 0.0 5.8e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.20 EAK87834.1 - 5.8e-10 39.1 0.8 2.1e-09 37.3 0.8 1.9 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_3 PF12641.7 EAK87834.1 - 0.02 14.6 0.2 0.081 12.6 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain Sec7 PF01369.20 EAK87835.1 - 8.3e-63 211.4 9.5 8.3e-63 211.4 9.5 2.2 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EAK87835.1 - 1.1e-19 70.9 0.3 1.1e-19 70.9 0.3 5.4 5 1 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal PI3_PI4_kinase PF00454.27 EAK87836.1 - 7.7e-40 137.3 0.0 2.2e-39 135.8 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EAK87836.1 - 2.6e-09 36.7 0.0 7.2e-09 35.3 0.0 1.8 1 0 0 1 1 1 1 FATC domain UME PF08064.13 EAK87836.1 - 0.011 15.6 0.2 0.16 11.9 0.0 3.1 2 0 0 2 2 2 0 UME (NUC010) domain PDCD2_C PF04194.13 EAK87837.1 - 4.4e-28 98.5 1.2 4.4e-28 98.5 1.2 1.5 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain SAS-6_N PF16531.5 EAK87839.1 - 1.7e-19 70.2 4.7 3e-19 69.4 4.7 1.4 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal ATR13 PF16829.5 EAK87841.1 - 0.049 14.0 0.5 0.48 10.8 0.1 2.3 2 0 0 2 2 2 0 Avirulence protein ATR13, RxLR effector Oxysterol_BP PF01237.18 EAK87842.1 - 2.1e-115 385.5 1.7 2.1e-115 385.5 1.7 2.0 2 0 0 2 2 2 1 Oxysterol-binding protein PH PF00169.29 EAK87842.1 - 1.1e-07 32.2 0.6 3.1e-07 30.9 0.6 1.8 1 0 0 1 1 1 1 PH domain WD40 PF00400.32 EAK87843.1 - 0.00039 21.1 11.0 0.91 10.5 0.3 5.3 5 1 1 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.6 EAK87843.1 - 0.037 14.5 0.2 13 6.4 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain PI-PLC-X PF00388.19 EAK87844.1 - 2e-59 199.3 0.0 3.8e-59 198.4 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EAK87844.1 - 3e-29 101.7 0.0 7.4e-29 100.4 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EAK87844.1 - 7.2e-11 42.3 0.0 1.6e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 EAK87844.1 - 1e-10 40.4 0.0 0.00012 21.4 0.0 3.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EAK87844.1 - 1.8e-08 34.1 0.1 4.1e-07 29.8 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK87844.1 - 3.3e-08 32.8 1.9 0.00056 19.6 0.1 4.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EAK87844.1 - 1.3e-07 32.0 4.5 8.5e-06 26.1 0.4 2.7 1 1 1 2 2 2 2 EF-hand domain pair Mcp5_PH PF12814.7 EAK87844.1 - 4.5e-05 23.6 0.1 0.00013 22.1 0.1 1.7 1 1 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_5 PF13202.6 EAK87844.1 - 0.00021 20.7 0.9 0.2 11.2 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 EAK87844.1 - 0.00085 19.1 0.1 0.0023 17.8 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_4 PF12763.7 EAK87844.1 - 0.0015 18.5 1.5 0.42 10.6 0.0 3.3 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand PH_12 PF16457.5 EAK87844.1 - 0.021 15.3 0.3 0.32 11.5 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain GDPD PF03009.17 EAK87844.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family AAA PF00004.29 EAK87845.1 - 2e-45 154.5 0.1 4e-44 150.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EAK87845.1 - 8.4e-10 38.5 0.1 5.2e-09 35.9 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EAK87845.1 - 2.2e-09 37.7 0.1 3e-08 34.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAK87845.1 - 1.2e-08 35.1 0.1 4.8e-08 33.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EAK87845.1 - 1.2e-06 28.2 0.0 2.9e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EAK87845.1 - 2.3e-06 28.1 0.3 0.00038 20.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EAK87845.1 - 3e-05 23.3 0.0 6.3e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EAK87845.1 - 3.3e-05 24.2 1.0 0.0073 16.6 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EAK87845.1 - 7.1e-05 23.4 0.0 0.00024 21.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EAK87845.1 - 8.8e-05 22.3 0.0 0.00028 20.7 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EAK87845.1 - 0.00028 21.2 0.0 0.00057 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EAK87845.1 - 0.00082 19.7 0.0 0.0019 18.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EAK87845.1 - 0.00083 19.3 0.2 0.017 15.0 0.0 2.6 3 0 0 3 3 3 1 NTPase TIP49 PF06068.13 EAK87845.1 - 0.00099 18.4 0.0 0.01 15.1 0.0 2.2 2 1 0 2 2 2 1 TIP49 P-loop domain AAA_3 PF07726.11 EAK87845.1 - 0.0013 18.6 0.1 0.044 13.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EAK87845.1 - 0.0016 17.9 0.1 0.0038 16.6 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EAK87845.1 - 0.0016 18.2 0.0 0.0041 16.9 0.0 1.8 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EAK87845.1 - 0.0016 18.6 0.0 0.0052 16.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EAK87845.1 - 0.005 16.8 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EAK87845.1 - 0.0057 16.2 0.1 0.036 13.6 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 EAK87845.1 - 0.0061 16.6 0.1 0.035 14.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EAK87845.1 - 0.0077 16.0 0.2 0.018 14.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EAK87845.1 - 0.0085 15.7 1.9 0.072 12.7 0.2 2.5 2 1 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EAK87845.1 - 0.0086 15.8 0.3 0.11 12.2 0.0 2.3 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_30 PF13604.6 EAK87845.1 - 0.017 14.8 0.3 0.041 13.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EAK87845.1 - 0.024 14.1 0.1 1.6 8.1 0.0 2.5 3 0 0 3 3 2 0 Bacterial TniB protein Parvo_NS1 PF01057.17 EAK87845.1 - 0.027 13.6 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 EAK87845.1 - 0.03 14.2 0.2 0.16 11.9 0.1 2.1 2 0 0 2 2 2 0 NACHT domain ATPase PF06745.13 EAK87845.1 - 0.034 13.5 1.0 0.88 8.9 0.0 2.7 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 EAK87845.1 - 0.049 13.5 0.9 0.66 9.8 0.0 2.5 2 1 0 3 3 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EAK87845.1 - 0.073 12.2 0.1 0.25 10.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain PhoH PF02562.16 EAK87845.1 - 0.11 12.0 0.1 0.26 10.7 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 EAK87845.1 - 0.14 12.0 1.2 0.45 10.3 0.1 2.1 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EAK87845.1 - 0.15 12.6 0.1 0.62 10.6 0.1 2.3 1 1 0 1 1 1 0 ABC transporter Sigma54_activ_2 PF14532.6 EAK87845.1 - 0.18 11.9 0.2 0.81 9.8 0.0 2.2 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_23 PF13476.6 EAK87845.1 - 0.76 10.2 3.8 15 6.0 0.0 2.4 2 1 0 2 2 2 0 AAA domain MSC PF09402.10 EAK87846.1 - 0.037 13.5 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain AIF_C PF14721.6 EAK87848.1 - 1.1 9.7 3.8 0.61 10.4 0.4 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TBCC PF07986.12 EAK87854.1 - 5.9e-24 84.1 2.5 8.6e-24 83.6 2.5 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EAK87854.1 - 0.11 12.2 6.3 0.083 12.5 1.9 2.0 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) C terminal Ank PF00023.30 EAK87856.1 - 3.1e-23 81.1 2.4 0.0016 18.8 0.0 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EAK87856.1 - 1.7e-22 79.5 0.1 5.8e-05 23.6 0.0 5.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAK87856.1 - 1.9e-22 79.6 0.0 1.1e-11 45.1 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EAK87856.1 - 4.2e-21 72.8 2.6 0.00054 20.2 0.0 6.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EAK87856.1 - 7e-17 61.3 0.2 0.002 18.4 0.0 5.1 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Sushi PF00084.20 EAK87856.1 - 8.3e-06 26.3 1.6 1e-05 26.0 0.4 1.9 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) SWIB PF02201.18 EAK87856.1 - 0.0057 16.5 0.1 0.025 14.5 0.1 2.0 2 0 0 2 2 2 1 SWIB/MDM2 domain Stevor PF17410.2 EAK87856.1 - 0.0067 16.0 0.1 0.012 15.1 0.1 1.4 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame DUF2970 PF11174.8 EAK87856.1 - 0.2 11.6 0.7 1.8 8.4 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Sigma_reg_N PF13800.6 EAK87856.1 - 1.5 9.1 5.6 3.1 8.1 1.3 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal IncF PF17626.2 EAK87857.1 - 0.0076 16.6 1.2 0.014 15.7 0.2 1.9 2 0 0 2 2 2 1 Inclusion membrane protein F TIP120 PF08623.10 EAK87857.1 - 7 6.4 11.8 6.5 6.5 2.0 3.4 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) Vps35 PF03635.17 EAK87859.1 - 1.4e-246 820.6 14.2 1.6e-246 820.4 14.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Npa1 PF11707.8 EAK87859.1 - 0.0077 15.6 0.1 0.0077 15.6 0.1 2.3 3 1 0 3 3 3 1 Ribosome 60S biogenesis N-terminal Propep_M14 PF02244.16 EAK87859.1 - 0.13 12.7 0.5 3.6 8.1 0.1 2.9 3 0 0 3 3 3 0 Carboxypeptidase activation peptide RTTN_N PF14726.6 EAK87859.1 - 1.1 10.1 4.8 39 5.1 0.7 4.0 3 1 1 4 4 4 0 Rotatin, an armadillo repeat protein, centriole functioning Mon1 PF03164.14 EAK87860.1 - 7.4e-50 170.2 25.5 1.2e-49 169.5 25.5 1.3 1 1 0 1 1 1 1 Trafficking protein Mon1 tRNA-synt_2 PF00152.20 EAK87861.1 - 8.4e-80 268.2 0.1 1.1e-79 267.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EAK87861.1 - 6.7e-09 35.6 0.0 2.2e-08 34.0 0.1 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EAK87861.1 - 3.3e-06 26.8 0.1 0.036 13.5 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) DUF4064 PF13273.6 EAK87862.1 - 0.011 16.0 11.7 2.9 8.2 5.3 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) Claudin_3 PF06653.11 EAK87863.1 - 0.076 13.0 2.7 0.41 10.6 2.7 2.0 1 1 0 1 1 1 0 Tight junction protein, Claudin-like FixS PF03597.15 EAK87863.1 - 0.69 9.7 8.0 0.12 12.1 3.5 1.9 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Met_gamma_lyase PF06838.11 EAK87864.1 - 0.15 10.5 0.1 0.21 10.0 0.1 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase DivIC PF04977.15 EAK87864.1 - 0.22 11.3 0.2 0.22 11.3 0.2 2.7 3 0 0 3 3 3 0 Septum formation initiator CENP-F_leu_zip PF10473.9 EAK87864.1 - 0.31 11.1 8.8 0.38 10.8 1.7 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KHA PF11834.8 EAK87866.1 - 0.031 14.3 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel PDT PF00800.18 EAK87867.1 - 0.033 14.0 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Prephenate dehydratase Rio2_N PF09202.11 EAK87867.1 - 0.13 12.4 0.1 0.42 10.9 0.1 1.8 1 0 0 1 1 1 0 Rio2, N-terminal DFP PF04127.15 EAK87868.1 - 1.8e-13 50.7 0.0 6.2e-06 26.2 0.0 2.6 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Dpy19 PF10034.9 EAK87869.1 - 1.2e-166 555.7 51.8 1.2e-166 555.7 51.8 2.1 2 0 0 2 2 2 1 Q-cell neuroblast polarisation TPR_17 PF13431.6 EAK87869.1 - 0.002 18.4 0.0 0.0064 16.8 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TAXi_N PF14543.6 EAK87870.1 - 3.8e-20 72.8 0.2 7.5e-20 71.9 0.2 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.23 EAK87870.1 - 6.3e-14 52.1 7.3 6.6e-13 48.8 7.3 2.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease gag-asp_proteas PF13975.6 EAK87870.1 - 0.044 14.3 0.0 0.54 10.9 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EAK87870.1 - 0.064 13.9 0.0 1.1 9.9 0.0 2.3 2 0 0 2 2 2 0 Aspartyl protease dsDNA_bind PF01984.20 EAK87871.1 - 3e-16 59.7 1.2 3.5e-16 59.4 1.2 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain CDT1 PF08839.11 EAK87874.1 - 3.8e-21 76.2 0.6 3.8e-21 76.2 0.6 3.2 3 1 0 3 3 3 1 DNA replication factor CDT1 like CDT1_C PF16679.5 EAK87874.1 - 0.016 15.6 0.1 0.049 14.1 0.1 1.9 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain SET PF00856.28 EAK87875.1 - 2.5e-10 41.0 0.7 1e-09 39.0 0.0 2.4 2 1 0 2 2 2 1 SET domain PX PF00787.24 EAK87876.1 - 1e-22 80.2 0.2 3.3e-22 78.6 0.2 1.9 1 0 0 1 1 1 1 PX domain RabGAP-TBC PF00566.18 EAK87877.1 - 3e-22 79.3 0.7 3e-22 79.3 0.7 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rad51 PF08423.11 EAK87878.1 - 2.7e-07 30.1 0.1 3.4e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Rad51 AAA_24 PF13479.6 EAK87878.1 - 0.0013 18.5 0.1 0.0019 17.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain Cyclin_N PF00134.23 EAK87879.1 - 1.8e-10 40.6 1.7 1.8e-10 40.6 1.7 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EAK87879.1 - 1.9e-05 24.7 0.4 8.5e-05 22.6 0.4 2.2 1 0 0 1 1 1 1 Cyclin, C-terminal domain VID27 PF08553.10 EAK87880.1 - 2.8e-55 187.8 0.6 3.9e-55 187.3 0.1 1.5 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain IL3Ra_N PF18611.1 EAK87880.1 - 0.49 10.4 2.4 1.5 8.8 2.3 1.8 1 1 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain CDC73_C PF05179.14 EAK87881.1 - 8.8e-42 142.5 0.6 8.8e-42 142.5 0.6 2.0 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal DUF5101 PF17031.5 EAK87881.1 - 0.042 13.9 2.9 4.2 7.5 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5101) ISP1_C PF18161.1 EAK87882.1 - 2.7e-25 88.5 0.3 2.7e-25 88.5 0.3 2.6 3 1 0 3 3 3 1 ISP1 C-terminal ISP3_C PF18045.1 EAK87882.1 - 1.1e-22 79.9 0.2 3e-22 78.6 0.2 1.7 1 0 0 1 1 1 1 ISP3 C-terminal Nop52 PF05997.12 EAK87883.1 - 2.4e-44 151.7 6.8 3.9e-44 151.0 5.3 2.1 1 1 0 1 1 1 1 Nucleolar protein,Nop52 RabGAP-TBC PF00566.18 EAK87884.1 - 3.6e-61 206.5 1.9 6.6e-61 205.7 1.9 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain BatD PF13584.6 EAK87885.1 - 0.038 12.8 0.0 0.046 12.5 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF4064 PF13273.6 EAK87885.1 - 0.041 14.1 0.1 0.062 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DUF3834 PF12916.7 EAK87885.1 - 0.075 12.3 0.0 0.098 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) RIFIN PF02009.16 EAK87885.1 - 0.09 12.7 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Rifin EGL-1 PF11430.8 EAK87885.1 - 0.23 11.4 2.4 0.46 10.4 2.4 1.5 1 0 0 1 1 1 0 Programmed cell death activator EGL-1 DUF676 PF05057.14 EAK87886.1 - 1.4e-23 83.5 0.0 7.9e-23 81.1 0.0 2.1 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EAK87886.1 - 0.00014 21.8 0.0 0.00027 20.8 0.0 1.6 1 1 0 1 1 1 1 Palmitoyl protein thioesterase KIP1 PF07765.12 EAK87886.1 - 0.33 11.1 2.9 0.48 10.6 2.0 1.8 1 1 0 1 1 1 0 KIP1-like protein Exo_endo_phos PF03372.23 EAK87887.1 - 3.5e-23 82.3 0.0 1.4e-22 80.4 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ORC2 PF04084.14 EAK87888.1 - 2e-41 142.0 7.7 2.8e-41 141.5 7.7 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Mce4_CUP1 PF11887.8 EAK87888.1 - 0.2 11.1 0.7 0.38 10.2 0.7 1.4 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF2278 PF10042.9 EAK87889.1 - 0.021 14.8 2.8 0.027 14.5 2.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) Rol_Rep_N PF18106.1 EAK87889.1 - 0.48 10.8 4.3 3.1 8.2 0.5 2.2 1 1 1 2 2 2 0 Rolling Circle replication initiation protein N-terminal domain YfhO PF09586.10 EAK87889.1 - 1.9 6.6 7.8 0.73 8.0 5.2 1.5 1 1 1 2 2 2 0 Bacterial membrane protein YfhO DUF2685 PF10886.8 EAK87890.1 - 0.085 13.1 0.2 0.82 9.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2685) AP2 PF00847.20 EAK87891.1 - 0.008 16.4 0.2 6 7.2 0.0 2.7 2 0 0 2 2 2 2 AP2 domain DUF3300 PF11737.8 EAK87891.1 - 0.02 14.4 0.1 0.071 12.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) HofP PF10748.9 EAK87891.1 - 0.071 12.7 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 DNA utilization proteins HofP A_deaminase PF00962.22 EAK87892.1 - 8.6e-92 307.9 0.0 5.4e-91 305.3 0.0 2.2 2 1 0 2 2 2 1 Adenosine/AMP deaminase DUF1965 PF09248.10 EAK87892.1 - 0.019 14.7 0.7 0.053 13.3 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) DUF865 PF05906.11 EAK87892.1 - 0.046 13.5 0.1 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus-7 repeat of unknown function (DUF865) Exo_endo_phos PF03372.23 EAK87894.1 - 2.6e-06 27.1 0.0 1.8e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C3HC4_3 PF13920.6 EAK87895.1 - 2.2e-06 27.4 3.0 4.2e-06 26.5 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK87895.1 - 9.2e-06 25.9 7.1 1.5e-05 25.2 6.4 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EAK87895.1 - 0.00016 21.6 5.4 0.00037 20.5 5.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EAK87895.1 - 0.00023 20.9 6.2 0.00046 20.0 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK87895.1 - 0.00068 19.4 7.7 0.0015 18.3 7.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK87895.1 - 0.0011 18.9 4.7 0.0022 17.9 4.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EAK87895.1 - 0.013 15.3 7.9 0.026 14.3 7.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EAK87895.1 - 0.018 14.8 1.4 0.018 14.8 1.4 2.0 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 EAK87895.1 - 0.078 12.9 9.3 1.9 8.4 8.2 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EAK87895.1 - 1.9 8.7 6.6 5.3 7.3 6.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Tctex-1 PF03645.13 EAK87898.1 - 2.8e-25 88.5 1.1 3.4e-25 88.2 1.1 1.1 1 0 0 1 1 1 1 Tctex-1 family KAR PF15222.6 EAK87898.1 - 0.02 15.2 1.4 0.045 14.0 1.0 1.7 1 1 1 2 2 2 0 Kidney androgen-regulated DELLA PF12041.8 EAK87898.1 - 0.12 12.2 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal AIM24 PF01987.17 EAK87901.1 - 0.0014 18.5 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF747 PF05346.11 EAK87902.1 - 3.8e-10 39.7 1.1 4.3e-10 39.6 1.1 1.0 1 0 0 1 1 1 1 Eukaryotic membrane protein family Wzy_C PF04932.15 EAK87902.1 - 0.063 12.9 3.8 0.093 12.4 3.8 1.3 1 0 0 1 1 1 0 O-Antigen ligase Pex26 PF07163.12 EAK87902.1 - 0.073 12.4 0.1 0.092 12.0 0.1 1.2 1 0 0 1 1 1 0 Pex26 protein CBP_BcsF PF11120.8 EAK87902.1 - 9.9 6.4 9.1 2.2 8.5 2.2 2.1 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsF DUF747 PF05346.11 EAK87903.1 - 8.7e-72 242.3 20.6 8.7e-72 242.3 20.6 1.5 2 0 0 2 2 2 1 Eukaryotic membrane protein family PGAP1 PF07819.13 EAK87904.1 - 1.8e-08 34.4 0.7 5.4e-08 32.8 0.7 1.9 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 EAK87904.1 - 0.0017 17.7 0.0 0.0038 16.5 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3837 PF12939.7 EAK87904.1 - 0.31 11.5 6.6 2.1 8.8 1.0 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3837) Brr6_like_C_C PF10104.9 EAK87906.1 - 3.9e-41 139.9 7.0 3.9e-41 139.9 7.0 2.2 2 0 0 2 2 2 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF2207 PF09972.9 EAK87906.1 - 0.046 12.5 7.1 0.074 11.8 6.1 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Claudin_2 PF13903.6 EAK87906.1 - 0.27 11.0 4.4 0.71 9.6 0.8 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4083 PF13314.6 EAK87906.1 - 5.8 6.9 14.9 1.1 9.2 6.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) Myosin_head PF00063.21 EAK87907.1 - 3.3e-132 442.0 33.2 1.2e-105 354.3 15.0 4.0 2 1 0 2 2 2 2 Myosin head (motor domain) AAA_16 PF13191.6 EAK87907.1 - 0.27 11.6 0.0 0.27 11.6 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain DUF4392 PF14336.6 EAK87909.1 - 1.2e-14 54.4 0.0 7.7e-14 51.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4392) Pkinase PF00069.25 EAK87912.1 - 2.3e-43 148.5 8.1 1.3e-42 146.1 8.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK87912.1 - 5.4e-27 94.7 0.2 1.1e-26 93.6 0.2 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase SNF2_N PF00176.23 EAK87914.1 - 1.5e-58 198.2 0.0 2.7e-58 197.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK87914.1 - 4.4e-20 72.1 0.0 1.1e-19 70.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EAK87914.1 - 3.1e-17 62.4 0.0 8.5e-17 61.0 0.0 1.8 1 0 0 1 1 1 1 Bromodomain Chromo PF00385.24 EAK87914.1 - 3.1e-12 46.2 0.1 2.1e-05 24.3 0.1 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 EAK87914.1 - 1.5e-08 34.9 0.0 6.4e-08 32.8 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EAK87914.1 - 0.00041 20.2 0.0 0.98 9.2 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase FtsJ PF01728.19 EAK87915.1 - 4.6e-59 199.5 0.2 2e-57 194.2 0.0 2.5 2 0 0 2 2 2 1 FtsJ-like methyltransferase Spb1_C PF07780.12 EAK87915.1 - 7.9e-48 162.9 20.8 7.9e-48 162.9 20.8 4.4 3 1 1 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.8 EAK87915.1 - 4.2e-32 111.2 17.1 4.2e-32 111.2 17.1 6.6 4 2 1 5 5 5 1 Domain of unknown function (DUF3381) SRP40_C PF05022.12 EAK87916.1 - 6e-20 71.9 6.8 6e-20 71.9 6.8 2.4 2 1 0 2 2 2 1 SRP40, C-terminal domain DUF4159 PF13709.6 EAK87916.1 - 0.032 13.6 0.2 0.077 12.4 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4159) V_ATPase_I PF01496.19 EAK87916.1 - 0.12 10.3 15.4 0.13 10.1 15.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TraI_2_C PF07515.11 EAK87916.1 - 0.91 9.5 7.7 0.94 9.4 3.9 2.3 1 1 1 2 2 2 0 Putative conjugal transfer nickase/helicase TraI C-term Spore_III_AB PF09548.10 EAK87916.1 - 1.8 8.6 5.8 0.47 10.6 2.6 1.6 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Cpn60_TCP1 PF00118.24 EAK87917.1 - 1.5e-153 512.0 1.7 1.7e-153 511.8 1.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EGF_2 PF07974.13 EAK87917.1 - 4.4 7.8 5.7 3.8 7.9 3.2 2.1 2 0 0 2 2 2 0 EGF-like domain Cpn60_TCP1 PF00118.24 EAK87918.1 - 1.5e-162 541.7 2.2 1.7e-162 541.5 2.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TPR_2 PF07719.17 EAK87919.1 - 1.4e-08 34.2 2.5 0.003 17.5 0.2 4.5 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EAK87919.1 - 0.00029 20.5 5.5 0.61 10.0 0.5 4.1 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EAK87919.1 - 0.082 13.2 0.1 0.61 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EAK87919.1 - 0.23 11.9 1.4 5.7 7.6 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EAK87919.1 - 0.28 11.5 9.9 5.1 7.6 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat CAF1C_H4-bd PF12265.8 EAK87920.1 - 3.3e-14 52.9 1.3 2.9e-13 49.9 0.3 2.7 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EAK87920.1 - 3.5e-11 43.5 12.1 7.6e-06 26.6 0.3 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK87920.1 - 0.00016 21.9 0.2 0.042 14.2 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EAK87920.1 - 0.0011 18.9 0.1 0.0026 17.7 0.1 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Histone PF00125.24 EAK87921.1 - 3.5e-52 176.2 1.1 3.9e-52 176.0 1.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EAK87921.1 - 0.00019 21.5 0.3 0.00038 20.5 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EAK87921.1 - 0.00031 21.1 0.0 0.00048 20.5 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EAK87921.1 - 0.0011 19.5 3.2 0.0015 19.1 3.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EAK87921.1 - 0.041 14.2 0.0 0.074 13.3 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EAK87921.1 - 0.056 13.5 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DEAD PF00270.29 EAK87922.1 - 3e-44 150.9 0.1 4.9e-44 150.2 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87922.1 - 4.3e-28 97.9 0.1 2.7e-27 95.3 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK87922.1 - 5.2e-06 26.6 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EAK87922.1 - 9e-05 21.8 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Alg6_Alg8 PF03155.15 EAK87923.1 - 1.9e-92 310.8 37.3 5.1e-92 309.3 37.3 1.6 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family EpsG PF14897.6 EAK87923.1 - 0.5 9.6 53.7 0.075 12.3 30.7 2.3 1 1 1 2 2 2 0 EpsG family WD40 PF00400.32 EAK87924.1 - 3.3e-25 87.9 16.1 5.9e-05 23.8 0.7 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK87924.1 - 4.3e-09 36.6 0.3 0.0047 17.2 0.0 5.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EAK87924.1 - 0.079 11.6 2.1 0.76 8.3 0.1 2.7 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Ribosomal_S27 PF01599.19 EAK87925.1 - 7.8e-24 83.6 2.0 7.8e-24 83.6 2.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S27a ubiquitin PF00240.23 EAK87925.1 - 1.6e-07 30.9 0.0 4.2e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin family Fer2_3 PF13085.6 EAK87925.1 - 0.051 13.6 0.5 0.094 12.7 0.5 1.5 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain IBR PF01485.21 EAK87925.1 - 0.054 13.7 0.3 0.092 13.0 0.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain PB1 PF00564.24 EAK87925.1 - 0.066 13.1 0.2 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 PB1 domain zf-C2H2_3 PF13878.6 EAK87925.1 - 0.075 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO CRAL_TRIO_2 PF13716.6 EAK87926.1 - 2.3e-28 99.1 2.7 5.5e-28 97.9 0.6 2.1 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EAK87926.1 - 4.1e-19 68.9 0.3 1.4e-18 67.2 0.1 2.0 2 0 0 2 2 2 1 RhoGAP domain DUF1708 PF08101.11 EAK87926.1 - 0.0035 16.5 0.0 0.0057 15.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) DUF3730 PF12530.8 EAK87926.1 - 0.019 14.5 0.2 5.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3730) CRAL_TRIO PF00650.20 EAK87926.1 - 0.046 13.4 0.3 0.18 11.5 0.3 2.0 1 1 0 1 1 1 0 CRAL/TRIO domain CDC45 PF02724.14 EAK87926.1 - 1.1 7.5 5.1 2 6.6 5.1 1.5 1 0 0 1 1 1 0 CDC45-like protein ERCC4 PF02732.15 EAK87927.1 - 1.1e-19 71.2 0.8 1.7e-19 70.5 0.1 1.6 2 0 0 2 2 2 1 ERCC4 domain Peptidase_M24 PF00557.24 EAK87928.1 - 1.2e-38 132.9 0.0 1.8e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 EAK87928.1 - 1.1e-33 116.7 4.8 1.3e-31 109.9 3.1 2.8 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EAK87928.1 - 1.2e-20 73.3 0.2 2.4e-20 72.4 0.2 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EAK87928.1 - 4.3e-15 56.5 0.0 4e-14 53.4 0.0 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain DUF2121 PF09894.9 EAK87928.1 - 0.00028 20.5 0.2 0.00059 19.4 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2121) Tubulin PF00091.25 EAK87929.1 - 3.4e-67 226.5 0.0 5e-67 225.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EAK87929.1 - 1e-50 171.1 0.4 2.1e-50 170.1 0.1 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EAK87929.1 - 0.024 14.3 0.0 0.056 13.1 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain EMG1 PF03587.14 EAK87930.1 - 1e-60 204.7 0.3 1.3e-60 204.4 0.3 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase EMG1 PF03587.14 EAK87931.1 - 8.3e-40 136.5 0.1 9.9e-40 136.3 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase SPOUT_MTase PF02590.17 EAK87931.1 - 0.0095 15.9 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase DnaJ_C PF01556.18 EAK87932.1 - 1e-32 113.3 0.0 1.4e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EAK87932.1 - 1.2e-26 92.6 1.9 2.3e-26 91.7 1.9 1.5 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EAK87932.1 - 0.13 12.2 0.1 0.98 9.4 0.0 2.5 3 1 0 3 3 3 0 A repeated domain in UCH-protein Bax1-I PF01027.20 EAK87933.1 - 1.3e-36 126.4 36.7 1.5e-36 126.2 36.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 polyprenyl_synt PF00348.17 EAK87934.1 - 3.3e-52 177.1 0.1 4.5e-52 176.6 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Ipi1_N PF12333.8 EAK87934.1 - 0.012 16.2 0.1 0.7 10.5 0.0 2.3 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation ubiquitin PF00240.23 EAK87935.1 - 1.4e-16 60.0 0.1 2.2e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EAK87935.1 - 7.5e-08 32.1 0.0 1.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EAK87935.1 - 7e-05 22.6 0.0 0.00021 21.1 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 EAK87935.1 - 0.0001 22.3 0.0 0.00021 21.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 EAK87935.1 - 0.00013 21.8 20.0 0.0039 17.1 0.6 4.0 3 1 1 4 4 4 1 STI1 domain DUF2407 PF10302.9 EAK87935.1 - 0.00021 21.8 0.1 0.00045 20.7 0.1 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain CUE PF02845.16 EAK87935.1 - 0.0016 18.1 0.6 0.0078 15.9 0.0 2.5 3 0 0 3 3 3 1 CUE domain TBK1_ULD PF18396.1 EAK87935.1 - 0.0084 16.0 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain HOIP-UBA PF16678.5 EAK87935.1 - 0.023 14.7 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair partial_CstF PF15861.5 EAK87935.1 - 0.4 10.5 2.3 1.4 8.7 0.0 2.6 2 1 0 2 2 2 0 Partial cleavage stimulation factor domain XPC-binding PF09280.11 EAK87935.1 - 2.8 7.7 16.7 27 4.6 14.3 3.3 1 1 1 2 2 2 0 XPC-binding domain ThiF PF00899.21 EAK87936.1 - 3.9e-91 304.8 0.0 4.1e-62 209.7 0.0 2.4 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EAK87936.1 - 1.4e-77 261.0 2.6 1.4e-77 261.0 2.6 1.5 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EAK87936.1 - 1e-22 80.1 0.2 3.3e-22 78.5 0.2 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EAK87936.1 - 6.6e-21 74.8 0.1 1.8e-20 73.4 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EAK87936.1 - 6.7e-12 45.4 0.0 1.5e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle AD PF09793.9 EAK87937.1 - 6.6e-17 61.4 0.1 2.9e-16 59.4 0.0 1.8 1 1 1 2 2 2 1 Anticodon-binding domain Gemin6 PF06372.12 EAK87937.1 - 0.0012 18.4 0.3 0.0093 15.5 0.0 2.0 1 1 1 2 2 2 1 Gemin6 protein RL10P_insert PF17777.1 EAK87938.1 - 7.5e-22 77.1 0.3 1.3e-21 76.3 0.3 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EAK87938.1 - 2.4e-19 69.3 0.1 5.1e-19 68.3 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 EAK87938.1 - 1.1e-08 35.6 0.2 3.8e-08 33.8 0.2 2.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3447 PF11929.8 EAK87939.1 - 0.94 9.5 7.1 0.3 11.1 3.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Adaptin_N PF01602.20 EAK87940.1 - 3.7e-71 240.3 29.9 5.9e-71 239.6 29.9 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EAK87940.1 - 6.5e-07 29.5 6.3 1.5e-05 25.1 0.2 3.5 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 KaiA PF07688.12 EAK87940.1 - 0.0011 19.1 0.9 0.0047 17.1 0.9 2.1 1 0 0 1 1 1 1 KaiA C-terminal domain HEAT PF02985.22 EAK87940.1 - 0.0075 16.4 0.9 25 5.5 0.1 4.4 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 EAK87940.1 - 0.17 12.3 0.1 17 5.9 0.1 2.6 2 0 0 2 2 2 0 HEAT repeats Vac14_Fab1_bd PF12755.7 EAK87940.1 - 0.5 11.0 3.1 7 7.3 0.0 4.0 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region PIGA PF08288.12 EAK87941.1 - 2.1e-41 140.4 1.8 6.3e-41 138.9 1.0 2.1 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EAK87941.1 - 9.7e-28 97.3 0.1 2.9e-27 95.7 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EAK87941.1 - 1.6e-27 96.2 0.0 3e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EAK87941.1 - 8.5e-23 81.3 0.0 1.6e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EAK87941.1 - 1.7e-09 38.3 0.0 2.8e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EAK87941.1 - 0.00031 20.8 0.1 0.0011 19.0 0.1 2.0 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EAK87941.1 - 0.052 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 DHHC PF01529.20 EAK87942.1 - 1.6e-30 106.0 19.2 1.6e-30 106.0 19.2 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase CTD_bind PF04818.13 EAK87943.1 - 6.5e-07 30.1 0.0 4.2e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase II-binding domain. zf-C2H2 PF00096.26 EAK87943.1 - 0.67 10.5 8.4 0.19 12.3 1.8 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type Histone PF00125.24 EAK87944.1 - 7.1e-31 107.3 0.0 7.9e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EAK87944.1 - 0.0015 18.7 0.0 0.004 17.4 0.0 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EAK87944.1 - 0.014 15.5 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EAK87944.1 - 0.072 13.3 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) ThiF PF00899.21 EAK87945.1 - 2.7e-43 148.1 0.1 3.7e-43 147.6 0.1 1.1 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EAK87945.1 - 0.0019 18.5 1.0 0.0079 16.5 1.0 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EAK87945.1 - 0.03 14.6 0.5 0.12 12.6 0.1 2.1 2 0 0 2 2 2 0 TrkA-N domain GAPT PF11770.8 EAK87945.1 - 0.061 13.2 2.4 0.13 12.1 2.4 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) UDPG_MGDP_dh_N PF03721.14 EAK87945.1 - 0.061 12.9 0.9 0.12 11.9 0.9 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PglD_N PF17836.1 EAK87945.1 - 0.071 13.8 0.2 0.21 12.2 0.2 2.0 1 0 0 1 1 1 0 PglD N-terminal domain NAD_binding_7 PF13241.6 EAK87945.1 - 0.071 13.5 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding RNase_PH PF01138.21 EAK87946.1 - 3.2e-17 63.3 0.0 5.7e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 NDK PF00334.19 EAK87947.1 - 8.6e-53 178.0 0.0 1e-52 177.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DEAD PF00270.29 EAK87948.1 - 7e-40 136.7 0.3 4.4e-39 134.1 0.1 2.4 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK87948.1 - 4.7e-22 78.4 1.9 2.9e-20 72.7 0.0 3.4 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EAK87948.1 - 1.2e-12 47.8 0.1 2.7e-12 46.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EAK87948.1 - 0.00042 20.4 5.8 0.0012 18.8 0.0 3.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EAK87948.1 - 0.0015 17.8 0.1 0.012 14.8 0.0 2.5 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase RNase_J_C PF17770.1 EAK87948.1 - 6.3 7.9 7.6 6.4 7.9 1.0 3.7 4 0 0 4 4 4 0 Ribonuclease J C-terminal domain AAA PF00004.29 EAK87949.1 - 7e-81 269.2 0.2 2.2e-48 164.0 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAK87949.1 - 4.6e-14 52.0 0.0 7.2e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EAK87949.1 - 1.3e-12 47.7 0.0 7.9e-05 22.5 0.0 3.0 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EAK87949.1 - 9.7e-12 45.3 0.0 7.9e-05 22.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAK87949.1 - 5.4e-10 39.4 0.6 0.0047 16.9 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK87949.1 - 6e-10 39.8 0.1 0.0023 18.4 0.1 4.4 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 EAK87949.1 - 9.8e-09 34.9 0.9 0.0083 15.4 0.0 3.6 2 1 1 3 3 3 2 TIP49 P-loop domain RNA_helicase PF00910.22 EAK87949.1 - 1.7e-06 28.3 0.1 0.048 14.1 0.0 3.8 3 0 0 3 3 3 2 RNA helicase AAA_14 PF13173.6 EAK87949.1 - 4.7e-06 26.7 7.6 0.022 14.8 0.2 4.5 4 1 1 5 5 5 2 AAA domain Mg_chelatase PF01078.21 EAK87949.1 - 9.4e-06 25.2 0.0 0.022 14.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EAK87949.1 - 1.5e-05 25.3 3.2 0.032 14.5 0.1 4.5 2 2 2 4 4 4 1 AAA domain IstB_IS21 PF01695.17 EAK87949.1 - 2.7e-05 24.0 0.0 0.073 12.8 0.0 2.9 2 2 1 3 3 3 2 IstB-like ATP binding protein AAA_33 PF13671.6 EAK87949.1 - 4e-05 23.8 0.0 0.51 10.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EAK87949.1 - 5.7e-05 22.9 1.8 0.0028 17.4 0.1 3.3 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EAK87949.1 - 0.00013 21.6 0.0 0.17 11.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 EAK87949.1 - 0.00013 22.5 0.2 0.022 15.3 0.0 3.6 3 1 0 3 3 3 1 AAA domain ABC_tran PF00005.27 EAK87949.1 - 0.0002 21.9 0.0 0.17 12.4 0.0 2.8 2 0 0 2 2 2 1 ABC transporter AAA_3 PF07726.11 EAK87949.1 - 0.00075 19.4 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EAK87949.1 - 0.0012 18.8 0.3 0.063 13.2 0.0 2.9 2 1 0 2 2 2 1 Rad17 P-loop domain ATPase PF06745.13 EAK87949.1 - 0.0012 18.2 0.3 0.58 9.5 0.0 3.0 3 0 0 3 3 2 1 KaiC NACHT PF05729.12 EAK87949.1 - 0.0013 18.6 0.0 0.14 12.1 0.0 3.5 3 1 0 3 3 3 1 NACHT domain TsaE PF02367.17 EAK87949.1 - 0.0024 17.9 0.0 0.65 10.0 0.0 2.8 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EAK87949.1 - 0.0025 17.0 0.0 0.074 12.1 0.0 2.5 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DUF815 PF05673.13 EAK87949.1 - 0.0025 17.0 0.0 1 8.5 0.0 2.7 3 0 0 3 3 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EAK87949.1 - 0.0028 17.4 0.0 0.92 9.2 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 EAK87949.1 - 0.0038 16.4 0.0 0.4 9.8 0.0 3.0 3 0 0 3 3 2 1 NB-ARC domain AAA_25 PF13481.6 EAK87949.1 - 0.0074 15.9 0.0 1.2 8.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 EAK87949.1 - 0.014 14.7 0.4 0.047 12.9 0.0 2.2 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 EAK87949.1 - 0.016 15.3 0.0 15 5.7 0.0 3.4 4 0 0 4 4 3 0 Sigma-54 interaction domain AAA_17 PF13207.6 EAK87949.1 - 0.019 15.4 0.0 6.7 7.1 0.0 3.0 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EAK87949.1 - 0.028 13.9 0.0 2.2 7.7 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 EAK87949.1 - 0.084 13.2 1.5 0.51 10.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain Viral_helicase1 PF01443.18 EAK87949.1 - 0.086 12.6 0.0 8.1 6.1 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 EAK87949.1 - 0.12 12.6 0.1 3.9 7.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EAK87949.1 - 0.16 11.2 0.0 12 5.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_11 PF13086.6 EAK87949.1 - 0.2 11.4 5.3 1.1 8.9 0.1 3.4 4 1 1 5 5 3 0 AAA domain AAA_30 PF13604.6 EAK87949.1 - 0.26 11.0 0.0 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EAK87949.1 - 0.67 9.9 8.8 2.9 7.9 2.5 4.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit NOG1_N PF17835.1 EAK87950.1 - 7.4e-48 162.5 1.3 1.6e-47 161.4 0.0 2.3 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 EAK87950.1 - 5.9e-27 93.2 0.3 1e-25 89.3 0.2 2.9 3 0 0 3 3 3 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 EAK87950.1 - 1.2e-25 89.2 4.8 2.7e-25 88.1 4.8 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 EAK87950.1 - 2.1e-18 66.5 0.0 8.7e-18 64.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAK87950.1 - 3e-10 39.8 0.0 1.2e-09 37.9 0.0 1.9 1 1 1 2 2 2 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EAK87950.1 - 0.0056 16.1 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EAK87950.1 - 0.0066 16.5 3.6 1.8 8.6 0.0 3.3 3 1 1 4 4 4 2 Dynamin family AAA_16 PF13191.6 EAK87950.1 - 0.015 15.7 0.0 1.5 9.2 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain AIG1 PF04548.16 EAK87950.1 - 0.027 13.8 0.1 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 EAK87950.1 - 0.044 13.7 0.4 1.1 9.2 0.0 3.2 3 1 0 3 3 3 0 RsgA GTPase TFA2_Winged_2 PF18121.1 EAK87950.1 - 0.095 12.4 0.2 0.31 10.8 0.2 1.8 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Roc PF08477.13 EAK87950.1 - 0.13 12.5 0.0 23 5.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Thioredoxin PF00085.20 EAK87951.1 - 3e-26 91.4 0.1 3.5e-26 91.2 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EAK87951.1 - 5.8e-05 23.3 0.0 6.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EAK87951.1 - 0.0019 18.1 0.1 0.002 18.0 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EAK87951.1 - 0.0053 16.5 0.1 0.0061 16.3 0.1 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 EAK87951.1 - 0.014 15.8 0.5 0.48 10.9 0.3 2.3 1 1 0 1 1 1 0 Thioredoxin-like domain SART-1 PF03343.13 EAK87952.1 - 8.1e-29 100.7 34.8 7.2e-26 90.9 34.8 2.3 1 1 0 1 1 1 1 SART-1 family Sec20 PF03908.13 EAK87953.1 - 5.1e-05 23.1 0.8 8.4e-05 22.4 0.7 1.4 1 1 0 1 1 1 1 Sec20 Use1 PF09753.9 EAK87953.1 - 0.00095 19.0 0.4 0.0011 18.7 0.4 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 ArsR PF09824.9 EAK87953.1 - 0.029 14.0 0.1 0.035 13.7 0.1 1.1 1 0 0 1 1 1 0 ArsR transcriptional regulator MannoseP_isomer PF01050.18 EAK87953.1 - 0.088 12.7 0.0 0.11 12.4 0.0 1.0 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Ribosomal_L31e PF01198.19 EAK87954.1 - 7.8e-38 128.6 0.7 9.2e-38 128.4 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Thioredoxin PF00085.20 EAK87955.1 - 1.6e-11 44.1 0.0 3e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Na_trans_assoc PF06512.13 EAK87955.1 - 4.7e-05 23.8 15.2 8.2e-05 23.0 15.0 1.7 1 1 0 1 1 1 1 Sodium ion transport-associated CDC45 PF02724.14 EAK87955.1 - 5.7e-05 21.6 30.8 8e-05 21.1 30.8 1.2 1 0 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EAK87955.1 - 0.0006 19.3 33.4 0.001 18.5 33.4 1.3 1 0 0 1 1 1 1 BUD22 Zip PF02535.22 EAK87955.1 - 0.00061 19.1 9.3 0.00061 19.1 9.3 1.8 2 0 0 2 2 2 1 ZIP Zinc transporter PA26 PF04636.13 EAK87955.1 - 0.002 17.1 11.5 0.0037 16.3 11.5 1.4 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Neur_chan_memb PF02932.16 EAK87955.1 - 0.0021 18.2 4.7 0.0021 18.2 4.7 1.6 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region CCSAP PF15748.5 EAK87955.1 - 0.011 15.9 28.0 0.011 15.9 28.0 1.8 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Spore_coat_CotO PF14153.6 EAK87955.1 - 0.013 15.5 27.1 0.013 15.5 27.1 1.9 2 0 0 2 2 2 0 Spore coat protein CotO OST3_OST6 PF04756.13 EAK87955.1 - 0.031 13.6 0.8 0.087 12.2 0.8 1.8 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EAK87955.1 - 0.047 14.2 0.0 0.16 12.4 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain HyaE PF07449.11 EAK87955.1 - 0.06 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Zn_peptidase PF04228.13 EAK87955.1 - 0.071 12.6 0.3 0.66 9.4 0.1 2.4 2 1 0 2 2 2 0 Putative neutral zinc metallopeptidase Nop14 PF04147.12 EAK87955.1 - 0.21 9.7 53.2 0.32 9.2 53.2 1.2 1 0 0 1 1 1 0 Nop14-like family XRN_M PF17846.1 EAK87955.1 - 0.25 10.2 14.6 0.42 9.5 14.6 1.3 1 0 0 1 1 1 0 Xrn1 helical domain Trypan_PARP PF05887.11 EAK87955.1 - 1.2 9.1 43.2 3.4 7.6 43.2 1.7 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Mpp10 PF04006.12 EAK87955.1 - 1.4 7.3 56.3 0.19 10.1 52.4 1.5 2 0 0 2 2 2 0 Mpp10 protein SLC12 PF03522.15 EAK87955.1 - 2.6 7.0 19.2 0.41 9.6 15.3 1.6 2 0 0 2 2 2 0 Solute carrier family 12 SDA1 PF05285.12 EAK87955.1 - 2.7 7.3 56.7 4.5 6.6 56.7 1.2 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 EAK87955.1 - 2.9 7.2 48.0 5 6.4 48.0 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Merozoite_SPAM PF07133.11 EAK87955.1 - 3.9 7.4 76.5 10 6.1 76.5 1.8 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop53 PF07767.11 EAK87955.1 - 5.3 6.3 49.7 11 5.3 49.7 1.6 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Glycos_transf_4 PF00953.21 EAK87956.1 - 1e-35 123.0 13.2 1e-35 123.0 13.2 2.5 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF4022 PF13214.6 EAK87957.1 - 0.042 14.1 3.2 0.071 13.4 3.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4022) GP41 PF00517.17 EAK87957.1 - 0.19 11.6 2.2 0.33 10.8 2.2 1.3 1 0 0 1 1 1 0 Retroviral envelope protein Actin PF00022.19 EAK87959.1 - 1.7e-120 402.4 0.0 2.2e-119 398.7 0.0 1.9 1 1 0 1 1 1 1 Actin SET PF00856.28 EAK87960.1 - 0.00061 20.2 2.0 0.036 14.4 0.0 3.0 2 2 1 3 3 3 2 SET domain UCH PF00443.29 EAK87961.1 - 9.6e-24 84.3 8.9 2.2e-23 83.1 8.9 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EAK87961.1 - 1.4e-08 34.9 3.0 3.6e-08 33.6 3.0 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein DUF4187 PF13821.6 EAK87961.1 - 0.095 12.5 0.2 0.25 11.2 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) PRE_C2HC PF07530.11 EAK87961.1 - 0.13 12.3 0.3 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Associated with zinc fingers Ribosomal_60s PF00428.19 EAK87962.1 - 5.8e-22 78.1 4.9 7.7e-22 77.7 4.7 1.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein Macoilin PF09726.9 EAK87963.1 - 0.02 13.5 18.5 0.029 12.9 18.5 1.2 1 0 0 1 1 1 0 Macoilin family Gcd10p PF04189.13 EAK87964.1 - 1.3e-18 67.2 20.0 5.9e-18 65.0 19.7 2.2 1 1 0 1 1 1 1 Gcd10p family DUF5130 PF17174.4 EAK87964.1 - 0.068 13.4 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5130) ABC1 PF03109.16 EAK87965.1 - 3.1e-29 101.6 0.3 5.7e-29 100.7 0.3 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EAK87965.1 - 7.1e-05 22.3 2.2 9.3e-05 21.9 0.6 1.8 2 0 0 2 2 2 1 Protein kinase domain CSG2 PF16965.5 EAK87966.1 - 1.4 7.8 17.7 4 6.3 17.7 1.8 1 0 0 1 1 1 0 Ceramide synthase regulator Dus PF01207.17 EAK87967.1 - 5.4e-43 147.2 0.0 1.6e-21 76.8 0.0 3.2 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EAK87967.1 - 0.48 10.4 2.6 0.37 10.7 0.4 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EAK87969.1 - 3e-07 30.2 0.0 6.3e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GCD14 PF08704.10 EAK87970.1 - 2.9e-61 207.3 0.3 1.8e-59 201.4 0.0 2.1 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EAK87970.1 - 2.6e-05 24.0 0.0 5.3e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EAK87970.1 - 8.2e-05 22.1 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase GCD14_N PF14801.6 EAK87970.1 - 0.00012 21.9 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term PCMT PF01135.19 EAK87970.1 - 0.00065 19.5 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 EAK87970.1 - 0.098 11.7 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase YIF1 PF03878.15 EAK87971.1 - 6.4e-06 25.9 3.3 9.1e-06 25.4 3.3 1.1 1 0 0 1 1 1 1 YIF1 Rad60-SLD PF11976.8 EAK87972.1 - 4.6e-10 39.2 0.0 3.9e-08 33.0 0.0 3.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like F-box-like PF12937.7 EAK87972.1 - 0.0024 17.7 1.4 0.0058 16.5 1.4 1.6 1 0 0 1 1 1 1 F-box-like ubiquitin PF00240.23 EAK87972.1 - 0.0054 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family F-box PF00646.33 EAK87972.1 - 0.0087 15.9 0.2 0.034 14.0 0.2 2.1 1 0 0 1 1 1 1 F-box domain UCH PF00443.29 EAK87973.1 - 1.4e-33 116.4 2.0 1.4e-33 116.4 2.0 4.1 4 0 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK87973.1 - 5e-10 39.5 3.3 5e-10 39.5 3.3 5.0 5 1 0 5 5 5 2 Ubiquitin carboxyl-terminal hydrolase CECR6_TMEM121 PF14997.6 EAK87974.1 - 2.9e-13 50.1 5.2 2.9e-13 50.1 5.2 2.2 2 0 0 2 2 2 1 CECR6/TMEM121 family WD40 PF00400.32 EAK87975.1 - 1.9e-09 38.0 19.3 0.066 14.1 0.0 9.6 10 1 0 10 10 10 2 WD domain, G-beta repeat NCBP3 PF10309.9 EAK87975.1 - 0.071 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 Mlh1_C PF16413.5 EAK87976.1 - 2.6e-34 118.8 4.7 2.6e-34 118.8 4.7 2.0 2 1 1 3 3 3 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EAK87976.1 - 2e-18 66.2 0.1 7.1e-18 64.4 0.1 2.0 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EAK87976.1 - 5.6e-13 48.9 0.9 1.6e-12 47.4 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EAK87976.1 - 6.3e-05 23.5 0.1 6.3e-05 23.5 0.1 2.7 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PTP_tm PF18861.1 EAK87977.1 - 0.17 11.9 3.1 0.29 11.1 3.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J zf-C2H2_4 PF13894.6 EAK87978.1 - 0.076 13.9 0.2 0.076 13.9 0.2 3.9 3 1 1 4 4 4 0 C2H2-type zinc finger zf-met PF12874.7 EAK87978.1 - 0.78 10.2 0.1 0.78 10.2 0.1 3.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Glycos_transf_2 PF00535.26 EAK87979.1 - 1.3e-17 64.1 0.1 1.9e-17 63.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EAK87979.1 - 0.0038 16.7 0.2 0.011 15.3 0.2 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 EAK87979.1 - 0.036 13.9 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 SWIB PF02201.18 EAK87980.1 - 0.00052 19.8 0.3 1.6 8.7 0.1 3.3 2 0 0 2 2 2 2 SWIB/MDM2 domain PUF PF00806.19 EAK87980.1 - 0.0009 18.8 0.0 0.016 14.9 0.0 3.2 2 0 0 2 2 2 1 Pumilio-family RNA binding repeat Chibby PF14645.6 EAK87981.1 - 0.035 14.5 1.1 0.056 13.9 0.1 1.8 2 0 0 2 2 2 0 Chibby family zf-RanBP PF00641.18 EAK87982.1 - 1.9 7.9 17.3 0.077 12.3 9.3 2.6 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Sdh_cyt PF01127.22 EAK87983.1 - 0.019 15.0 4.3 0.029 14.4 4.3 1.3 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Sigma_reg_N PF13800.6 EAK87983.1 - 0.59 10.4 9.1 1.6 9.1 2.3 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal ATP-synt_8 PF00895.20 EAK87983.1 - 6.3 7.3 6.4 5 7.7 1.1 2.3 2 0 0 2 2 2 0 ATP synthase protein 8 OppC_N PF12911.7 EAK87983.1 - 9.2 6.3 9.6 15 5.6 2.7 2.6 2 1 1 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Peptidase_M16_C PF05193.21 EAK87984.1 - 7.7e-06 26.0 0.1 0.00038 20.5 0.2 2.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain DUF5624 PF18538.1 EAK87984.1 - 0.25 11.5 1.2 1.3 9.1 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5624) WxL PF13731.6 EAK87985.1 - 0.0035 17.4 3.1 0.02 15.0 0.0 2.3 2 0 0 2 2 2 1 WxL domain surface cell wall-binding SecD-TM1 PF13721.6 EAK87985.1 - 0.2 12.2 0.6 1.1 9.7 0.1 2.5 2 0 0 2 2 2 0 SecD export protein N-terminal TM region CagY_I PF14585.6 EAK87986.1 - 0.039 14.0 1.9 0.53 10.4 1.9 2.6 1 1 0 1 1 1 0 CagY type 1 repeat Lig_C PF18330.1 EAK87986.1 - 0.97 9.5 3.0 2 8.5 0.1 2.9 3 0 0 3 3 3 0 Ligase Pab1020 C-terminal region RNase_J_C PF17770.1 EAK87989.1 - 0.011 16.8 0.1 0.14 13.2 0.0 2.9 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain WH2 PF02205.20 EAK87989.1 - 0.06 13.2 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 WH2 motif Draxin PF15550.6 EAK87989.1 - 0.85 9.4 6.6 1.5 8.6 6.6 1.4 1 0 0 1 1 1 0 Draxin Phage_fiber_2 PF03406.13 EAK87990.1 - 0.11 12.1 0.1 0.3 10.7 0.1 1.7 1 0 0 1 1 1 0 Phage tail fibre repeat SOBP PF15279.6 EAK87990.1 - 9.1 6.8 11.2 12 6.5 11.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein S10_plectin PF03501.15 EAK87991.1 - 1.6e-38 130.7 0.2 1.9e-38 130.4 0.2 1.0 1 0 0 1 1 1 1 Plectin/S10 domain AAA PF00004.29 EAK87992.1 - 1.1e-37 129.4 0.0 2.3e-37 128.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EAK87992.1 - 1.7e-07 31.1 0.0 6.5e-07 29.2 0.0 2.1 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 EAK87992.1 - 9.6e-07 28.5 0.0 2.4e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EAK87992.1 - 9.2e-06 25.9 0.0 2.6e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAK87992.1 - 7.9e-05 22.7 0.6 0.0064 16.5 0.2 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EAK87992.1 - 0.00019 21.7 0.2 0.0015 18.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EAK87992.1 - 0.0028 17.6 0.0 0.006 16.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 EAK87992.1 - 0.0029 18.0 0.0 0.0092 16.4 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EAK87992.1 - 0.0031 17.5 0.1 0.13 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EAK87992.1 - 0.0032 17.9 0.1 0.023 15.1 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EAK87992.1 - 0.0038 16.6 0.1 0.0073 15.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EAK87992.1 - 0.0069 16.9 0.0 0.026 15.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EAK87992.1 - 0.0081 15.8 0.0 0.14 11.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EAK87992.1 - 0.0093 15.2 0.0 0.02 14.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 EAK87992.1 - 0.022 14.5 0.3 0.095 12.4 0.2 2.2 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EAK87992.1 - 0.042 13.6 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EAK87992.1 - 0.066 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EAK87992.1 - 0.091 11.9 0.1 6.3 5.9 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF815) MCM PF00493.23 EAK87992.1 - 0.12 11.4 0.0 0.3 10.1 0.0 1.6 1 0 0 1 1 1 0 MCM P-loop domain AAA_33 PF13671.6 EAK87992.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EAK87992.1 - 0.16 11.4 0.2 5.6 6.3 0.0 2.9 3 0 0 3 3 3 0 Bacterial TniB protein Chorein_N PF12624.7 EAK87994.1 - 2.7e-21 75.9 1.2 2.7e-21 75.9 1.2 3.2 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EAK87994.1 - 6.5e-08 32.7 12.4 0.00035 20.5 0.4 4.6 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal Secretin_N_2 PF07655.13 EAK87996.1 - 0.66 10.5 19.6 4.6 7.9 9.5 2.9 2 0 0 2 2 2 0 Secretin N-terminal domain VPS13_C PF16909.5 EAK87997.1 - 1.4e-08 34.7 2.0 3.8e-07 30.0 0.3 3.0 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal eIF3m_C_helix PF18005.1 EAK87998.1 - 0.13 12.0 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 eIF3 subunit M, C-terminal helix DUF641 PF04859.12 EAK87999.1 - 0.084 13.2 16.6 0.17 12.2 0.1 3.9 4 0 0 4 4 4 0 Plant protein of unknown function (DUF641) DUF948 PF06103.11 EAK87999.1 - 0.13 12.6 7.4 8.7 6.7 0.0 4.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EAK87999.1 - 0.16 12.1 0.1 0.061 13.5 8.8 5.9 5 2 0 5 5 5 0 Fibrinogen alpha/beta chain family bZIP_1 PF00170.21 EAK87999.1 - 6.4 7.0 17.1 0.79 9.9 1.8 4.2 2 1 0 3 3 3 0 bZIP transcription factor SlyX PF04102.12 EAK87999.1 - 6.6 7.4 19.4 1.9 9.2 3.6 4.7 4 2 1 5 5 5 0 SlyX Cep57_MT_bd PF06657.13 EAK87999.1 - 7.6 7.1 14.8 0.65 10.5 1.2 3.9 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 RNA_helicase PF00910.22 EAK88000.1 - 0.0032 17.9 0.9 0.0082 16.5 0.9 1.7 1 0 0 1 1 1 1 RNA helicase zf-CCCH_3 PF15663.5 EAK88000.1 - 0.029 14.6 1.5 0.029 14.6 1.5 2.9 2 1 1 3 3 3 0 Zinc-finger containing family CLP1_P PF16575.5 EAK88002.1 - 1.9e-29 102.8 0.0 3.2e-26 92.3 0.0 2.4 1 1 1 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EAK88002.1 - 4.7e-19 68.4 0.0 1e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor CbiA PF01656.23 EAK88002.1 - 6.4e-06 26.2 0.1 1.8e-05 24.8 0.1 2.0 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EAK88002.1 - 0.00078 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EAK88002.1 - 0.0017 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EAK88002.1 - 0.0056 16.8 0.0 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Clp1 PF06807.14 EAK88002.1 - 0.031 14.7 0.0 0.093 13.2 0.0 1.8 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 AAA_18 PF13238.6 EAK88002.1 - 0.068 13.7 0.1 0.23 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EAK88002.1 - 0.078 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EAK88002.1 - 0.091 13.3 0.1 0.21 12.1 0.1 1.8 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 EAK88002.1 - 0.14 11.9 0.0 0.44 10.3 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Peptidase_C48 PF02902.19 EAK88003.1 - 1.1e-39 136.5 2.9 2.2e-39 135.6 2.9 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PP2C PF00481.21 EAK88004.1 - 1.9e-10 40.8 0.1 0.00033 20.4 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EAK88004.1 - 1.5e-07 31.6 0.0 0.00085 19.3 0.0 2.6 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EAK88004.1 - 0.00024 20.8 0.0 0.054 13.1 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C FHA PF00498.26 EAK88006.1 - 8.7e-15 54.8 0.2 2.6e-14 53.3 0.2 1.9 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EAK88006.1 - 0.00064 20.0 0.3 0.0035 17.6 0.0 2.4 2 1 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF4394 PF14339.6 EAK88006.1 - 0.014 14.8 0.1 0.021 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) Glyco_hydro_43 PF04616.14 EAK88006.1 - 0.072 12.4 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 DUF961 PF06125.11 EAK88006.1 - 3.4 8.1 7.2 2.8 8.4 3.1 2.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF961) Sec63 PF02889.16 EAK88007.1 - 7.4e-33 113.8 0.0 1.6e-32 112.7 0.0 1.6 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_PWI PF18149.1 EAK88007.1 - 1.2e-31 109.1 1.5 1.2e-31 109.1 1.5 2.6 3 0 0 3 3 3 1 N-terminal helicase PWI domain DEAD PF00270.29 EAK88007.1 - 3.8e-23 82.2 3.7 4.2e-23 82.0 0.1 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EAK88007.1 - 1.4e-12 48.0 1.5 2.3e-11 44.0 0.0 3.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EAK88007.1 - 1.9e-09 37.8 0.7 4.2e-06 27.1 0.1 3.6 2 1 0 2 2 2 2 Helicase conserved C-terminal domain FtsK_SpoIIIE PF01580.18 EAK88007.1 - 0.014 14.8 0.1 0.073 12.4 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_19 PF13245.6 EAK88007.1 - 0.49 10.7 2.3 0.96 9.8 0.0 2.5 3 1 0 3 3 3 0 AAA domain ECM11 PF15463.6 EAK88009.1 - 4.8 7.8 10.1 11 6.6 10.1 1.6 1 0 0 1 1 1 0 Extracellular mutant protein 11 RGS-like PF09128.11 EAK88010.1 - 0.0035 17.1 1.4 0.0044 16.8 1.4 1.1 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain NPV_P10 PF05531.12 EAK88010.1 - 0.012 16.0 3.9 0.016 15.6 3.9 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein RP-C_C PF11800.8 EAK88010.1 - 0.26 11.3 5.6 0.29 11.2 5.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region CHD5 PF04420.14 EAK88010.1 - 0.32 10.8 3.0 0.4 10.5 3.0 1.2 1 1 0 1 1 1 0 CHD5-like protein Nse4_C PF08743.10 EAK88011.1 - 0.0013 19.0 2.1 0.0025 18.0 0.1 2.5 2 0 0 2 2 2 1 Nse4 C-terminal COesterase PF00135.28 EAK88013.1 - 1.5e-59 202.3 2.2 4.3e-59 200.7 1.8 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EAK88013.1 - 9.7e-11 41.9 0.0 6.8e-10 39.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1749 PF08538.10 EAK88013.1 - 0.01 15.0 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.21 EAK88013.1 - 0.035 13.6 0.0 0.084 12.3 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family CENP-F_leu_zip PF10473.9 EAK88013.1 - 0.43 10.6 5.7 0.36 10.9 0.3 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Acetyltransf_1 PF00583.25 EAK88014.1 - 3.2e-08 33.8 0.0 3.9e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EAK88014.1 - 2.5e-07 31.0 0.0 3.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EAK88014.1 - 0.00012 22.0 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EAK88014.1 - 0.00016 21.6 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EAK88014.1 - 0.0054 16.8 0.1 0.014 15.5 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_5 PF07728.14 EAK88015.1 - 3.7e-85 282.9 0.2 1.8e-23 83.1 0.0 9.2 6 3 1 7 7 7 7 AAA domain (dynein-related subfamily) AAA_lid_5 PF17865.1 EAK88015.1 - 2.9e-41 139.9 4.3 4.6e-39 132.8 0.2 3.4 3 0 0 3 3 2 1 Midasin AAA lid domain AAA_lid_7 PF17867.1 EAK88015.1 - 7e-25 87.3 2.0 9.7e-11 41.8 0.2 5.0 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_3 PF07726.11 EAK88015.1 - 2.4e-23 82.4 0.0 1.9e-07 31.0 0.0 6.7 7 0 0 7 7 7 3 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 EAK88015.1 - 4e-16 59.2 0.5 0.001 19.2 0.0 6.7 6 1 0 6 6 5 2 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 EAK88015.1 - 1.3e-15 57.4 10.3 0.00055 19.5 0.1 5.4 6 0 0 6 6 4 4 P-loop containing dynein motor region AAA PF00004.29 EAK88015.1 - 7.5e-14 52.3 0.6 0.053 14.0 0.0 5.5 4 1 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EAK88015.1 - 2.5e-13 50.8 0.0 0.17 12.3 0.0 5.3 4 1 0 5 5 4 4 AAA ATPase domain ABC_tran PF00005.27 EAK88015.1 - 1e-12 48.8 1.4 0.0005 20.6 0.1 5.3 4 0 0 4 4 4 2 ABC transporter AAA_6 PF12774.7 EAK88015.1 - 8.8e-12 44.6 8.6 0.0037 16.3 1.8 7.7 7 1 0 7 7 7 3 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 EAK88015.1 - 2.2e-11 43.7 0.3 0.063 13.0 0.0 5.5 6 0 0 6 6 5 3 Sigma-54 interaction domain AAA_22 PF13401.6 EAK88015.1 - 1.2e-10 41.8 1.8 0.061 13.6 0.0 6.1 6 0 0 6 6 5 2 AAA domain Mg_chelatase PF01078.21 EAK88015.1 - 1.7e-10 40.7 0.0 0.29 10.5 0.0 5.8 6 0 0 6 6 6 3 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EAK88015.1 - 3.4e-10 40.6 20.3 0.00037 21.0 0.1 7.5 8 1 1 9 9 4 3 AAA domain T2SSE PF00437.20 EAK88015.1 - 2.5e-08 33.3 9.9 0.0051 15.9 0.1 5.4 6 0 0 6 6 6 2 Type II/IV secretion system protein TsaE PF02367.17 EAK88015.1 - 5.3e-08 32.9 0.4 0.34 10.9 0.0 4.8 4 0 0 4 4 4 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 EAK88015.1 - 1.6e-07 31.4 1.2 0.039 13.9 0.0 4.9 4 0 0 4 4 4 1 RsgA GTPase AAA_14 PF13173.6 EAK88015.1 - 2.6e-06 27.5 38.8 0.016 15.2 0.0 10.5 10 1 1 11 11 9 3 AAA domain DUF815 PF05673.13 EAK88015.1 - 2.7e-06 26.7 0.1 1.2 8.3 0.0 4.5 4 0 0 4 4 4 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EAK88015.1 - 3.2e-06 27.5 0.6 1.3 9.3 0.0 5.2 5 0 0 5 5 4 1 AAA domain AAA_28 PF13521.6 EAK88015.1 - 5.6e-06 26.7 0.3 2.5 8.3 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.6 EAK88015.1 - 5.7e-06 26.0 2.4 0.002 17.8 0.0 4.3 4 0 0 4 4 4 1 P-loop containing region of AAA domain PduV-EutP PF10662.9 EAK88015.1 - 1.3e-05 25.0 5.7 0.16 11.7 0.0 4.6 5 0 0 5 5 4 2 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EAK88015.1 - 4e-05 23.3 0.0 5.3 6.6 0.0 3.6 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EAK88015.1 - 4.5e-05 23.8 2.6 12 6.3 0.0 6.0 5 0 0 5 5 5 0 RNA helicase Roc PF08477.13 EAK88015.1 - 6e-05 23.2 1.4 0.62 10.3 0.0 4.4 4 0 0 4 4 3 1 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 EAK88015.1 - 6.1e-05 22.9 0.0 1 9.1 0.0 4.6 5 1 0 5 5 3 1 DEAD/DEAH box helicase AAA_23 PF13476.6 EAK88015.1 - 9.2e-05 23.0 13.3 9.2e-05 23.0 13.3 11.0 6 6 2 8 8 2 1 AAA domain AAA_30 PF13604.6 EAK88015.1 - 0.0001 22.1 0.0 4.7 6.9 0.0 5.4 6 0 0 6 6 6 0 AAA domain SRPRB PF09439.10 EAK88015.1 - 0.00014 21.4 3.5 0.17 11.3 0.0 4.8 5 0 0 5 5 5 1 Signal recognition particle receptor beta subunit Sigma54_activ_2 PF14532.6 EAK88015.1 - 0.0002 21.5 0.0 1.5 9.0 0.0 4.6 4 0 0 4 4 4 1 Sigma-54 interaction domain MCM PF00493.23 EAK88015.1 - 0.00024 20.3 1.6 0.35 9.9 0.0 4.5 5 0 0 5 5 4 1 MCM P-loop domain TniB PF05621.11 EAK88015.1 - 0.00024 20.6 2.1 0.64 9.4 0.0 4.5 4 0 0 4 4 4 1 Bacterial TniB protein IstB_IS21 PF01695.17 EAK88015.1 - 0.00039 20.2 0.0 0.89 9.3 0.0 4.0 4 0 0 4 4 3 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 EAK88015.1 - 0.0004 19.7 0.0 7.2 5.8 0.0 4.4 4 0 0 4 4 4 0 Zeta toxin AAA_24 PF13479.6 EAK88015.1 - 0.00048 19.9 0.2 1.9 8.1 0.0 4.8 5 0 0 5 5 5 1 AAA domain NACHT PF05729.12 EAK88015.1 - 0.00054 19.9 5.9 3.9 7.4 0.0 5.2 6 0 0 6 6 4 0 NACHT domain RuvB_N PF05496.12 EAK88015.1 - 0.0007 19.4 2.2 1.9 8.2 0.0 5.1 6 0 0 6 6 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EAK88015.1 - 0.00076 19.7 0.0 14 5.8 0.0 4.3 4 0 0 4 4 4 0 AAA domain MMR_HSR1 PF01926.23 EAK88015.1 - 0.0014 18.7 0.2 19 5.4 0.0 4.5 4 0 0 4 4 3 0 50S ribosome-binding GTPase SRP54 PF00448.22 EAK88015.1 - 0.0035 17.0 1.4 1.1 8.8 0.1 3.1 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain ResIII PF04851.15 EAK88015.1 - 0.0037 17.3 16.2 0.77 9.7 0.1 6.5 6 0 0 6 6 6 1 Type III restriction enzyme, res subunit ATP-synt_ab PF00006.25 EAK88015.1 - 0.019 14.6 0.2 21 4.7 0.0 3.5 4 0 0 4 4 4 0 ATP synthase alpha/beta family, nucleotide-binding domain CPT PF07931.12 EAK88015.1 - 0.026 14.4 0.0 13 5.6 0.0 4.0 4 1 0 4 4 4 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 EAK88015.1 - 0.032 14.2 6.4 6.3 6.7 0.0 5.8 8 0 0 8 8 4 0 NTPase FtsK_SpoIIIE PF01580.18 EAK88015.1 - 0.079 12.3 0.3 1.2 8.4 0.0 3.0 3 0 0 3 3 2 0 FtsK/SpoIIIE family HVSL PF09749.9 EAK88016.1 - 2e-07 30.7 1.6 1.2e-06 28.2 1.6 2.1 1 1 0 1 1 1 1 Uncharacterised conserved protein EF-hand_1 PF00036.32 EAK88017.1 - 3e-06 26.4 8.9 0.011 15.2 1.8 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EAK88017.1 - 3e-06 27.6 0.5 0.045 14.2 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EAK88017.1 - 7.3e-05 22.5 1.8 0.034 14.0 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK88017.1 - 0.0026 17.5 7.3 0.47 10.5 0.8 3.4 2 0 0 2 2 2 2 EF-hand domain RNA_pol_Rpa2_4 PF06883.12 EAK88017.1 - 0.0068 16.4 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain EF-hand_4 PF12763.7 EAK88017.1 - 0.031 14.2 2.6 6.1 6.9 0.2 3.0 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EAK88017.1 - 0.084 12.4 7.8 0.049 13.1 1.6 2.7 2 0 0 2 2 2 0 EF hand He_PIG PF05345.12 EAK88017.1 - 0.32 11.2 3.1 0.22 11.7 0.2 2.3 2 0 0 2 2 2 0 Putative Ig domain Glycos_transf_1 PF00534.20 EAK88018.1 - 3.6e-37 127.5 0.0 6.6e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EAK88018.1 - 1e-26 94.0 0.0 1.7e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EAK88018.1 - 5.9e-22 78.5 0.1 2.8e-21 76.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EAK88018.1 - 1.4e-17 64.6 0.0 4.4e-17 63.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 EAK88018.1 - 2.7e-15 56.8 0.0 9.1e-15 55.0 0.0 1.9 1 1 0 1 1 1 1 Starch synthase catalytic domain Alpha-amylase_C PF02806.18 EAK88018.1 - 2.9e-05 24.4 0.1 9.3e-05 22.8 0.1 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EAK88018.1 - 3.5e-05 23.5 0.0 0.00021 20.9 0.0 2.2 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_trans_1_2 PF13524.6 EAK88018.1 - 0.012 16.0 0.0 0.04 14.3 0.0 1.9 1 0 0 1 1 1 0 Glycosyl transferases group 1 Pkinase PF00069.25 EAK88019.1 - 1.7e-15 57.1 0.0 6e-10 38.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88019.1 - 1.8e-11 43.9 0.0 8.9e-08 31.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EAK88019.1 - 0.02 14.2 0.0 0.056 12.8 0.0 1.6 2 0 0 2 2 2 0 Kinase-like SAM_2 PF07647.17 EAK88020.1 - 0.0061 16.6 0.1 0.012 15.7 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EAK88020.1 - 0.027 14.9 0.2 0.052 14.0 0.2 1.5 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) USP7_ICP0_bdg PF12436.8 EAK88020.1 - 0.028 13.7 1.8 0.099 11.9 0.2 2.0 2 0 0 2 2 2 0 ICP0-binding domain of Ubiquitin-specific protease 7 AMP-binding PF00501.28 EAK88021.1 - 2.5e-74 250.4 0.0 3.3e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Proteasome PF00227.26 EAK88023.1 - 8.4e-26 90.6 0.2 4.2e-21 75.3 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit CENP-P PF13096.6 EAK88023.1 - 0.0019 17.9 0.1 0.0032 17.2 0.1 1.2 1 0 0 1 1 1 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P FadA PF09403.10 EAK88023.1 - 0.035 14.6 0.5 0.093 13.2 0.3 1.7 1 1 1 2 2 2 0 Adhesion protein FadA Glyco_transf_8 PF01501.20 EAK88025.1 - 1.8e-07 31.0 0.5 2.1e-07 30.8 0.5 1.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EAK88025.1 - 0.06 12.7 0.1 0.092 12.1 0.1 1.3 1 0 0 1 1 1 0 Glucosyltransferase 24 DUF1168 PF06658.12 EAK88026.1 - 1.5e-15 57.2 20.8 2e-15 56.8 20.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) TFIIS_M PF07500.14 EAK88027.1 - 4.1e-18 65.9 2.0 4.1e-18 65.9 2.0 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain zf-HC5HC2H_2 PF13832.6 EAK88028.1 - 1.9e-24 85.9 22.8 3.2e-08 33.7 0.5 6.2 5 1 0 5 5 5 4 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EAK88028.1 - 7.3e-11 42.2 8.6 1.2e-06 28.7 1.2 6.2 6 1 1 7 7 7 2 PHD-like zinc-binding domain PHD PF00628.29 EAK88028.1 - 2.3e-09 37.0 44.5 1.2e-06 28.3 3.0 5.0 4 0 0 4 4 4 2 PHD-finger PHD_2 PF13831.6 EAK88028.1 - 8.2e-09 34.9 28.4 7.6e-06 25.4 2.3 3.5 3 0 0 3 3 3 2 PHD-finger Keratin_2_head PF16208.5 EAK88028.1 - 0.4 10.8 13.5 1.3 9.1 13.5 1.8 1 0 0 1 1 1 0 Keratin type II head KRTAP PF11759.8 EAK88028.1 - 2 9.1 9.5 6.8 7.3 9.5 1.9 1 0 0 1 1 1 0 Keratin-associated matrix DER1 PF04511.15 EAK88030.1 - 1e-45 156.0 16.1 1.2e-45 155.9 16.1 1.0 1 0 0 1 1 1 1 Der1-like family Kazal_2 PF07648.15 EAK88032.1 - 7.7e-07 29.1 6.4 0.021 15.0 4.1 2.6 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EAK88032.1 - 0.00025 21.0 5.1 0.31 11.1 0.0 2.6 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain TPT PF03151.16 EAK88034.1 - 6.2e-24 84.9 24.3 7.8e-24 84.5 24.3 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EAK88034.1 - 7.4e-10 38.5 19.5 7.4e-10 38.5 19.5 1.8 1 1 1 2 2 2 1 UAA transporter family EamA PF00892.20 EAK88034.1 - 5.9e-09 36.2 33.2 9.8e-06 25.8 12.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family TSP_1 PF00090.19 EAK88035.1 - 4.6e-38 129.2 226.9 1.3e-08 34.9 4.2 19.6 20 2 0 20 20 20 11 Thrombospondin type 1 domain Notch PF00066.17 EAK88035.1 - 6.2e-23 81.0 140.6 8.7e-08 32.5 14.8 13.1 14 0 0 14 14 14 6 LNR domain DnaJ PF00226.31 EAK88036.1 - 1.8e-24 85.6 1.2 3.5e-24 84.7 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.11 EAK88036.1 - 1.4e-14 54.3 0.4 1.4e-14 54.3 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) SR-25 PF10500.9 EAK88036.1 - 0.048 13.3 9.9 0.087 12.4 9.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PRAI PF00697.22 EAK88036.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Macoilin PF09726.9 EAK88036.1 - 0.18 10.3 9.7 0.22 10.0 9.7 1.2 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 EAK88036.1 - 1.1 8.4 6.2 0.23 10.6 3.4 1.4 2 0 0 2 2 2 0 ZIP Zinc transporter SelP_N PF04592.14 EAK88036.1 - 5.5 6.3 14.8 11 5.3 14.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NAC PF01849.18 EAK88038.1 - 6.7e-16 58.0 0.0 1.4e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 NAC domain UBA_4 PF14555.6 EAK88038.1 - 0.002 17.9 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Spc24 PF08286.11 EAK88038.1 - 0.034 14.4 3.2 3.3 8.0 2.0 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 YqfQ PF14181.6 EAK88038.1 - 0.66 10.2 6.0 3.4 7.8 1.8 2.2 2 0 0 2 2 2 0 YqfQ-like protein 5_nucleotid_C PF02872.18 EAK88039.1 - 1.3e-33 116.5 0.0 3.4e-33 115.1 0.0 1.7 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EAK88039.1 - 1.2e-10 42.2 0.3 2e-10 41.5 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DTW PF03942.15 EAK88040.1 - 8.9e-25 87.6 0.1 1.2e-24 87.1 0.1 1.2 1 0 0 1 1 1 1 DTW domain 4HBT PF03061.22 EAK88041.1 - 9.2e-06 25.9 0.0 1.4e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Par3_HAL_N_term PF12053.8 EAK88041.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins BPL_N PF09825.9 EAK88042.1 - 4.7e-09 35.8 0.0 5.7e-09 35.5 0.0 1.3 1 1 0 1 1 1 1 Biotin-protein ligase, N terminal Ipi1_N PF12333.8 EAK88043.1 - 0.11 13.1 0.1 0.52 10.9 0.0 2.1 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation DnaJ PF00226.31 EAK88044.1 - 1.8e-07 31.2 0.0 2.5e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 EAK88044.1 - 1.2e-05 25.3 0.0 1.2e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Pam16 GLTP PF08718.11 EAK88045.1 - 5.9e-24 85.0 0.1 1.2e-23 84.0 0.1 1.5 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) 2-oxogl_dehyd_N PF16078.5 EAK88046.1 - 0.1 12.2 0.8 0.29 10.7 0.2 2.1 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus SbmA_BacA PF05992.12 EAK88047.1 - 3e-62 210.9 11.0 3.4e-62 210.7 11.0 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family SbmA_BacA PF05992.12 EAK88048.1 - 3e-56 191.2 14.7 3.4e-56 191.0 14.7 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 EAK88048.1 - 2e-13 50.4 8.0 7e-13 48.6 8.0 1.9 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 Csm1_B PF18211.1 EAK88049.1 - 0.14 12.0 1.8 1.8 8.5 0.2 2.9 2 0 0 2 2 2 0 Csm1 subunit domain B Gpi1 PF05024.15 EAK88050.1 - 3e-38 131.8 19.9 3e-38 131.8 19.9 3.1 2 2 1 3 3 3 1 N-acetylglucosaminyl transferase component (Gpi1) RRM_1 PF00076.22 EAK88051.1 - 3.3e-30 103.7 0.2 6.1e-14 51.6 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EAK88051.1 - 0.0012 19.1 0.0 0.89 9.8 0.0 2.5 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EAK88051.1 - 0.036 14.2 0.2 15 5.8 0.0 3.4 2 2 0 2 2 2 0 RNA recognition motif DUF4523 PF15023.6 EAK88051.1 - 0.055 13.3 0.0 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Endonuclease_NS PF01223.23 EAK88052.1 - 5.8e-39 134.2 0.0 9.2e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease YfcL PF08891.11 EAK88052.1 - 0.13 12.7 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 YfcL protein HALZ PF02183.18 EAK88053.1 - 0.081 13.2 4.7 0.19 12.0 4.6 1.6 1 1 0 1 1 1 0 Homeobox associated leucine zipper DUF4047 PF13256.6 EAK88053.1 - 2.3 8.4 6.2 0.48 10.6 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Zip PF02535.22 EAK88055.1 - 3.1e-36 125.3 11.8 3.8e-36 125.0 11.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Helicase_RecD PF05127.14 EAK88056.1 - 0.16 11.8 0.3 0.38 10.6 0.3 1.6 1 0 0 1 1 1 0 Helicase zf-CCHC_4 PF14392.6 EAK88056.1 - 1.2 8.9 7.0 1.6 8.5 0.6 2.8 2 0 0 2 2 2 0 Zinc knuckle Chromo PF00385.24 EAK88057.1 - 1.5e-10 40.8 0.5 4.6e-10 39.3 0.5 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1980 PF09323.10 EAK88057.1 - 0.13 12.1 0.8 0.54 10.1 0.8 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) RCC1_2 PF13540.6 EAK88057.1 - 0.22 11.4 1.0 6.4 6.7 0.1 3.1 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Plant_all_beta PF10532.9 EAK88057.1 - 1.3 9.3 6.0 26 5.1 2.5 3.0 2 0 0 2 2 2 0 Plant specific N-all beta domain RWD PF05773.22 EAK88058.1 - 6.2e-06 26.5 6.9 2.9e-05 24.3 6.9 2.2 1 1 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EAK88058.1 - 0.00023 21.6 1.3 0.00023 21.6 1.3 2.1 2 0 0 2 2 2 1 DRG Family Regulatory Proteins, Tma46 Elf1 PF05129.13 EAK88059.1 - 3.8e-26 90.9 3.9 6.9e-26 90.1 3.9 1.5 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 EAK88059.1 - 0.015 15.7 0.3 0.053 13.9 0.2 1.9 2 0 0 2 2 2 0 Restriction alleviation protein Lar Rubredoxin PF00301.20 EAK88059.1 - 0.13 12.3 1.1 7.4 6.7 0.1 2.4 2 0 0 2 2 2 0 Rubredoxin FdhE PF04216.12 EAK88059.1 - 0.16 11.8 0.2 0.33 10.8 0.2 1.4 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation FCH PF00611.23 EAK88060.1 - 3.9e-10 39.9 0.6 2.4e-09 37.3 0.2 2.7 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Nipped-B_C PF12830.7 EAK88061.1 - 4.5e-10 39.8 0.9 4.5e-10 39.8 0.9 3.9 5 0 0 5 5 5 1 Sister chromatid cohesion C-terminus PHD PF00628.29 EAK88061.1 - 7.2e-05 22.6 6.8 7.2e-05 22.6 6.8 2.9 3 0 0 3 3 3 1 PHD-finger Cnd1 PF12717.7 EAK88061.1 - 0.0022 18.0 1.1 0.0022 18.0 1.1 5.5 6 0 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Arm_3 PF16186.5 EAK88061.1 - 0.015 14.8 0.0 0.28 10.8 0.0 2.5 2 0 0 2 2 2 0 Atypical Arm repeat HEAT PF02985.22 EAK88061.1 - 0.022 15.0 1.5 7.1 7.2 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat CCDC24 PF15669.5 EAK88061.1 - 0.17 11.8 1.3 0.4 10.5 1.3 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PHD_4 PF16866.5 EAK88061.1 - 3.3 7.9 10.2 0.36 10.9 3.7 2.8 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.6 EAK88061.1 - 4.3 7.0 9.2 0.15 11.6 2.1 2.3 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 EAK88061.1 - 5.5 7.0 10.5 0.16 11.9 0.6 3.1 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_Tnp_IS1595 PF12760.7 EAK88061.1 - 9.8 6.3 6.2 2.5 8.2 1.5 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DEAD PF00270.29 EAK88062.1 - 2.4e-18 66.5 0.0 7.4e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EAK88062.1 - 8.8e-13 48.6 0.8 1.3e-11 44.8 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EAK88062.1 - 7.4e-06 26.3 0.0 4.7e-05 23.7 0.0 2.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain KIP1 PF07765.12 EAK88062.1 - 0.02 15.0 1.1 7.5 6.7 0.1 3.2 2 0 0 2 2 2 0 KIP1-like protein DUF2790 PF10976.8 EAK88062.1 - 0.021 14.8 0.0 0.052 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2790) SSP160 PF06933.11 EAK88063.1 - 0.061 11.5 7.6 0.092 10.9 7.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RP-C_C PF11800.8 EAK88063.1 - 0.22 11.6 0.9 25 4.9 0.4 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region FHA PF00498.26 EAK88064.1 - 1.1e-17 64.1 0.9 3.5e-17 62.5 0.9 2.0 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EAK88064.1 - 7.8e-09 35.7 0.0 4e-08 33.5 0.0 2.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PI_PP_I PF18363.1 EAK88064.1 - 0.46 10.7 3.3 1 9.6 0.6 2.6 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain PITH PF06201.13 EAK88065.1 - 1e-19 71.3 1.7 1.5e-19 70.7 1.7 1.2 1 0 0 1 1 1 1 PITH domain CAP PF00188.26 EAK88066.1 - 1.6e-18 67.8 2.5 2.9e-18 66.9 2.5 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family RIO1 PF01163.22 EAK88067.1 - 5.9e-54 182.5 0.2 2.2e-28 99.2 0.0 2.6 1 1 1 2 2 2 2 RIO1 family FERM_C PF09380.10 EAK88069.1 - 0.04 14.3 0.1 0.096 13.1 0.0 1.6 1 1 1 2 2 2 0 FERM C-terminal PH-like domain CPBP PF02517.16 EAK88071.1 - 1.6e-09 38.0 1.5 1.6e-09 38.0 1.5 2.3 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease EF-hand_1 PF00036.32 EAK88073.1 - 0.0026 17.2 5.8 0.0047 16.4 1.6 2.8 2 0 0 2 2 2 1 EF hand DUF812 PF05667.11 EAK88073.1 - 0.0032 16.4 27.2 0.0047 15.9 27.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) EF-hand_6 PF13405.6 EAK88073.1 - 0.0041 16.9 2.2 0.029 14.3 0.9 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EAK88073.1 - 0.0064 16.9 4.9 0.0064 16.9 4.9 2.7 3 0 0 3 3 3 1 EF-hand domain pair TolA_bind_tri PF16331.5 EAK88073.1 - 0.14 12.3 8.3 0.51 10.5 8.3 2.0 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF4239 PF14023.6 EAK88073.1 - 0.42 10.3 3.1 6 6.5 2.0 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF4239) WDCP PF15390.6 EAK88073.1 - 0.97 7.7 13.7 1.2 7.4 13.7 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family EF-hand_5 PF13202.6 EAK88073.1 - 4.3 7.0 7.4 9.6 5.9 2.1 2.9 2 0 0 2 2 2 0 EF hand THP2 PF09432.10 EAK88074.1 - 0.0055 16.8 1.1 0.1 12.7 0.1 2.6 1 1 2 3 3 3 1 Tho complex subunit THP2 FliT PF05400.13 EAK88074.1 - 0.0092 16.8 0.5 7.8 7.4 0.0 3.0 2 1 1 3 3 3 1 Flagellar protein FliT DUF2203 PF09969.9 EAK88074.1 - 0.011 16.5 0.3 22 5.8 0.1 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) GLE1 PF07817.13 EAK88074.1 - 0.019 14.2 4.4 0.2 10.9 0.2 2.5 2 1 0 2 2 2 0 GLE1-like protein COG2 PF06148.11 EAK88074.1 - 0.021 14.9 3.5 0.34 11.0 0.2 3.0 2 2 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CCDC-167 PF15188.6 EAK88074.1 - 0.024 14.9 0.7 0.29 11.5 0.0 2.3 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Helicase_Sgs1 PF11408.8 EAK88074.1 - 0.062 13.4 0.0 6.2 6.9 0.0 2.5 1 1 0 2 2 2 0 Sgs1 RecQ helicase TSNAXIP1_N PF15739.5 EAK88074.1 - 0.1 13.0 4.5 0.23 11.8 0.6 2.5 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF4407 PF14362.6 EAK88074.1 - 0.11 11.8 1.6 0.3 10.4 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 EAK88074.1 - 0.25 11.9 4.7 1.2 9.6 3.2 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 HMMR_N PF15905.5 EAK88074.1 - 0.43 10.0 6.6 0.19 11.1 1.9 2.2 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal ATG16 PF08614.11 EAK88074.1 - 0.64 10.2 5.0 26 5.0 0.0 3.6 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Nucleoporin_FG PF13634.6 EAK88074.1 - 1.1 10.2 20.3 0.3 12.0 10.4 2.2 1 1 1 2 2 2 0 Nucleoporin FG repeat region Las1 PF04031.13 EAK88075.1 - 9.7e-34 116.7 0.0 3.7e-33 114.8 0.0 2.1 1 0 0 1 1 1 1 Las1-like Trm5_N PF18093.1 EAK88075.1 - 0.26 11.2 2.9 0.47 10.4 0.6 2.5 2 0 0 2 2 2 0 tRNA methyltransferase 5 N-terminal domain LETM1 PF07766.13 EAK88076.1 - 3.9e-49 167.4 7.8 4.5e-49 167.2 7.8 1.0 1 0 0 1 1 1 1 LETM1-like protein Nucleo_P87 PF07267.11 EAK88076.1 - 0.021 13.7 1.1 0.027 13.3 1.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NUC153 PF08159.12 EAK88077.1 - 3.2e-11 42.9 8.6 1.4e-07 31.2 0.4 3.4 3 0 0 3 3 3 2 NUC153 domain DUF5089 PF17002.5 EAK88079.1 - 0.009 15.9 14.4 0.022 14.7 13.4 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF5089) Dynamitin PF04912.14 EAK88079.1 - 0.0092 15.4 7.3 0.0095 15.3 0.7 2.1 2 0 0 2 2 2 1 Dynamitin Sec20 PF03908.13 EAK88079.1 - 0.018 14.9 4.7 0.021 14.8 1.2 2.2 2 0 0 2 2 2 0 Sec20 NPV_P10 PF05531.12 EAK88079.1 - 0.025 15.0 7.9 0.12 12.9 2.1 2.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 EAK88079.1 - 0.078 13.2 0.4 0.078 13.2 0.4 3.4 3 1 1 4 4 4 0 Haemolysin XhlA V-SNARE_C PF12352.8 EAK88079.1 - 0.23 11.8 4.5 8.6 6.7 0.5 2.4 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus PspA_IM30 PF04012.12 EAK88079.1 - 0.36 10.4 9.7 0.17 11.5 7.1 1.6 2 0 0 2 2 2 0 PspA/IM30 family GAT PF03127.14 EAK88079.1 - 0.37 11.1 7.5 0.69 10.3 3.7 2.6 2 1 0 2 2 2 0 GAT domain DUF1664 PF07889.12 EAK88079.1 - 0.49 10.4 9.2 6.6 6.8 0.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EAK88079.1 - 0.54 10.4 12.7 1.2 9.3 0.5 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Sin3_corepress PF08295.12 EAK88079.1 - 0.78 9.9 4.9 0.28 11.3 1.6 1.9 2 1 0 2 2 2 0 Sin3 family co-repressor Muted PF14942.6 EAK88079.1 - 0.92 9.8 15.3 2.5 8.4 7.8 2.5 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein HOOK PF05622.12 EAK88079.1 - 1 7.4 14.1 0.048 11.8 7.7 1.7 2 0 0 2 2 2 0 HOOK protein TMPIT PF07851.13 EAK88079.1 - 1.6 7.9 8.8 0.67 9.1 2.8 2.0 2 0 0 2 2 2 0 TMPIT-like protein YtxH PF12732.7 EAK88079.1 - 2.8 8.5 6.0 35 5.0 3.6 2.6 2 1 0 2 2 2 0 YtxH-like protein DUF948 PF06103.11 EAK88079.1 - 3.7 7.9 7.6 14 6.1 0.6 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Uds1 PF15456.6 EAK88079.1 - 5.8 7.1 9.4 2.3 8.4 5.5 2.2 2 2 1 3 3 3 0 Up-regulated During Septation HMMR_N PF15905.5 EAK88079.1 - 6.7 6.1 16.2 0.9 8.9 10.7 1.9 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal UPF0242 PF06785.11 EAK88079.1 - 9.5 6.3 16.5 1.9 8.6 9.4 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Gar1 PF04410.14 EAK88081.1 - 9.4e-36 122.9 0.0 1.2e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Ras PF00071.22 EAK88082.1 - 0.00012 21.7 0.2 0.00018 21.1 0.0 1.3 2 0 0 2 2 2 1 Ras family Peptidase_C57 PF03290.13 EAK88082.1 - 0.00058 18.7 0.7 0.00073 18.4 0.7 1.1 1 0 0 1 1 1 1 Vaccinia virus I7 processing peptidase DUF2556 PF10831.8 EAK88083.1 - 0.2 11.7 1.7 0.39 10.7 1.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2556) Methyltr_RsmB-F PF01189.17 EAK88084.1 - 1.9e-17 63.5 0.2 3.1e-17 62.9 0.2 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PRP3 PF08572.10 EAK88085.1 - 3.1e-37 128.5 5.5 3.1e-37 128.5 5.5 1.6 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EAK88085.1 - 7.3e-26 91.0 6.9 1.5e-25 90.0 0.3 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1115) CTP_synth_N PF06418.14 EAK88086.1 - 3.6e-107 357.6 0.2 5.2e-107 357.1 0.2 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EAK88086.1 - 4.3e-44 150.6 0.0 1.2e-43 149.1 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EAK88086.1 - 0.0093 15.7 0.3 0.97 9.1 0.1 2.8 3 0 0 3 3 3 1 Peptidase C26 CbiA PF01656.23 EAK88086.1 - 0.042 13.9 0.0 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EAK88086.1 - 0.067 12.2 0.1 0.12 11.3 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CactinC_cactus PF09732.9 EAK88087.1 - 2.2e-42 144.0 5.9 5.2e-42 142.7 5.9 1.7 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 EAK88087.1 - 1.1e-05 25.3 6.6 0.00012 21.9 6.5 2.4 1 1 0 1 1 1 1 Conserved mid region of cactin U3_assoc_6 PF08640.11 EAK88087.1 - 0.00034 20.6 2.6 0.00034 20.6 2.6 2.7 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 BUD22 PF09073.10 EAK88090.1 - 0.0035 16.8 14.4 0.0044 16.4 14.4 1.2 1 0 0 1 1 1 1 BUD22 DNA_pol_phi PF04931.13 EAK88090.1 - 0.0075 14.4 20.6 0.011 13.9 20.6 1.2 1 0 0 1 1 1 1 DNA polymerase phi Sporozoite_P67 PF05642.11 EAK88090.1 - 0.17 9.9 12.1 0.24 9.5 11.7 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 EAK88090.1 - 3.5 6.0 13.3 4.8 5.6 13.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pab87_oct PF13969.6 EAK88092.1 - 0.083 13.0 0.0 4.1 7.6 0.0 2.3 1 1 1 2 2 2 0 Pab87 octamerisation domain Yip1 PF04893.17 EAK88093.1 - 9.2e-06 25.5 15.4 2.2e-05 24.2 15.4 1.7 1 1 0 1 1 1 1 Yip1 domain DUF4118 PF13493.6 EAK88099.1 - 1.9 8.3 8.3 2.7 7.9 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) AA_permease_2 PF13520.6 EAK88099.1 - 3.6 6.3 14.1 4.3 6.0 14.1 1.1 1 0 0 1 1 1 0 Amino acid permease Pox_polyA_pol_N PF12630.7 EAK88100.1 - 3.6 8.0 7.2 3.7 8.0 0.5 4.0 3 0 0 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain NADH-UOR_E PF16514.5 EAK88103.1 - 0.0065 16.8 0.5 0.17 12.2 0.1 3.1 2 1 1 3 3 3 1 putative NADH-ubiquinone oxidoreductase chain E DUF948 PF06103.11 EAK88104.1 - 8.1 6.8 5.6 3.5 8.0 0.6 3.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF3037 PF11236.8 EAK88105.1 - 0.9 10.0 4.0 0.49 10.8 0.2 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3037) Tcf25 PF04910.14 EAK88107.1 - 2.6e-44 151.7 8.4 4.1e-44 151.1 8.4 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 NTF2 PF02136.20 EAK88108.1 - 0.74 10.4 3.8 0.55 10.8 0.9 2.0 1 1 1 2 2 2 0 Nuclear transport factor 2 (NTF2) domain PRELI PF04707.14 EAK88109.1 - 3e-26 92.1 0.5 3e-26 92.1 0.5 1.4 2 0 0 2 2 2 1 PRELI-like family DUF4806 PF16064.5 EAK88109.1 - 4.3 7.7 9.9 3.5 8.0 5.6 2.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4806) Dynein_AAA_lid PF17852.1 EAK88110.1 - 0.018 15.1 0.1 0.027 14.6 0.1 1.3 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain zf-CCCH_4 PF18044.1 EAK88111.1 - 0.0077 16.0 1.6 0.0077 16.0 1.6 3.7 4 0 0 4 4 4 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EAK88111.1 - 0.0082 16.3 0.3 0.022 15.0 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH PF00642.24 EAK88111.1 - 0.3 11.1 22.3 0.079 12.9 1.3 4.5 4 1 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3883 PF13020.6 EAK88113.1 - 1.8e-23 82.4 0.1 2.2e-23 82.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) RRM_1 PF00076.22 EAK88114.1 - 7.4e-17 60.9 0.0 1.2e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAK88114.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif CS PF04969.16 EAK88115.1 - 0.0004 21.3 0.9 0.0029 18.6 0.9 2.3 1 1 0 1 1 1 1 CS domain TPR_7 PF13176.6 EAK88116.1 - 2.6e-09 36.5 5.5 0.76 9.9 0.0 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAK88116.1 - 3.5e-09 36.2 20.3 0.048 13.9 0.2 9.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 EAK88116.1 - 2.9e-08 33.8 1.8 8.2 7.3 0.0 8.5 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 EAK88116.1 - 9.4e-07 28.5 16.3 0.85 9.9 0.0 8.5 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 EAK88116.1 - 2.9e-05 24.3 4.4 8.1 6.8 0.0 6.8 8 1 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 EAK88116.1 - 0.00013 22.0 0.0 0.031 14.4 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EAK88116.1 - 0.00025 21.5 0.6 6.7 7.3 0.0 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EAK88116.1 - 0.0011 18.6 21.3 0.56 10.1 1.0 6.4 7 0 0 7 7 7 3 Tetratricopeptide repeat RPN7 PF10602.9 EAK88116.1 - 0.0014 18.4 11.5 0.36 10.5 0.8 4.7 3 1 1 4 4 4 2 26S proteasome subunit RPN7 ANAPC3 PF12895.7 EAK88116.1 - 0.01 16.0 16.2 0.087 13.1 1.5 5.5 4 2 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EAK88116.1 - 0.021 14.5 1.6 2.6 7.8 0.0 4.5 5 0 0 5 5 5 0 TPR repeat Alkyl_sulf_dimr PF14863.6 EAK88116.1 - 0.028 14.8 0.1 18 5.8 0.0 3.0 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 EAK88116.1 - 0.08 12.8 1.4 6.6 6.7 0.2 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Guanylate_cyc PF00211.20 EAK88117.1 - 1.6e-30 106.1 0.1 3.1e-30 105.2 0.1 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF4296 PF14129.6 EAK88117.1 - 0.96 10.1 6.4 1.2 9.7 1.9 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4296) Topoisom_I_N PF02919.15 EAK88118.1 - 2.1 7.8 6.7 2.3 7.7 1.4 2.7 1 1 1 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Sec62 PF03839.16 EAK88119.1 - 1.3e-28 100.0 1.3 2e-28 99.4 1.3 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 Dymeclin PF09742.9 EAK88120.1 - 9.8e-82 275.3 38.7 3.1e-81 273.7 38.7 1.7 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein RIBIOP_C PF04950.12 EAK88121.1 - 6.3e-91 304.8 0.2 1.1e-90 304.0 0.2 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EAK88121.1 - 1.8e-16 60.0 0.0 4.2e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain RNA_pol_Rpc4 PF05132.14 EAK88122.1 - 0.00018 22.0 0.0 0.0068 16.8 0.0 2.6 1 1 1 2 2 2 1 RNA polymerase III RPC4 DUF2718 PF10918.8 EAK88124.1 - 2.3 8.7 5.4 0.84 10.1 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) zf-B_box PF00643.24 EAK88125.1 - 1.4e-06 28.3 9.6 1.4e-06 28.3 9.6 3.0 4 0 0 4 4 4 2 B-box zinc finger Methyltransf_25 PF13649.6 EAK88125.1 - 0.016 15.9 0.1 1.1 10.1 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain zf-ANAPC11 PF12861.7 EAK88125.1 - 0.045 13.8 0.8 0.045 13.8 0.8 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EAK88125.1 - 0.64 9.9 37.3 0.14 12.0 8.6 4.3 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) BTB PF00651.31 EAK88126.1 - 3.8e-13 49.6 0.0 6.8e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Whirly PF08536.11 EAK88126.1 - 0.0079 16.0 0.0 0.063 13.1 0.0 2.0 2 0 0 2 2 2 1 Whirly transcription factor CENP-F_C_Rb_bdg PF10490.9 EAK88126.1 - 0.02 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Rb-binding domain of kinetochore protein Cenp-F/LEK1 Med26 PF08711.11 EAK88127.1 - 2.8e-05 24.0 4.6 3.9e-05 23.6 2.1 2.3 2 0 0 2 2 2 1 TFIIS helical bundle-like domain RsbRD_N PF14361.6 EAK88127.1 - 0.026 15.2 0.2 1.6 9.5 0.0 2.7 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Epimerase PF01370.21 EAK88128.1 - 3.4e-28 98.7 0.0 8.3e-28 97.5 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EAK88128.1 - 1.1e-20 73.8 0.2 1.7e-20 73.2 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EAK88128.1 - 3.6e-20 72.2 0.0 3.8e-19 68.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EAK88128.1 - 9.4e-16 58.1 0.0 1.5e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EAK88128.1 - 8e-14 51.9 0.0 1.2e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EAK88128.1 - 1.7e-09 37.6 0.0 3.6e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EAK88128.1 - 2.7e-07 30.0 0.0 4.3e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EAK88128.1 - 3.5e-05 23.8 0.0 8.4e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EAK88128.1 - 0.001 18.3 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EAK88128.1 - 0.003 17.0 0.0 0.015 14.8 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 EAK88128.1 - 0.093 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SANT_DAMP1_like PF16282.5 EAK88129.1 - 1.6e-27 95.5 2.4 4.2e-27 94.1 2.4 1.8 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 STATa_Ig PF18214.1 EAK88129.1 - 0.04 13.9 0.3 0.17 11.9 0.1 2.3 1 1 0 1 1 1 0 STATa Immunoglobulin-like domain SSXT PF05030.12 EAK88130.1 - 1.9e-05 24.2 0.2 4.9e-05 22.9 0.2 1.7 1 0 0 1 1 1 1 SSXT protein (N-terminal region) zf-C2H2 PF00096.26 EAK88130.1 - 0.0042 17.5 3.8 0.014 15.8 3.8 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 EAK88130.1 - 0.016 14.8 0.7 0.037 13.7 0.7 1.6 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain PyrI_C PF02748.15 EAK88130.1 - 0.068 13.1 5.2 1.9 8.4 0.3 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF1189 PF06691.11 EAK88130.1 - 0.17 11.4 3.3 0.1 12.2 1.3 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1189) zf-C2H2_4 PF13894.6 EAK88130.1 - 0.75 10.8 6.4 0.28 12.1 2.9 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Torus PF16131.5 EAK88132.1 - 4.3e-08 33.8 15.0 3.6e-05 24.4 0.7 3.6 2 1 2 4 4 4 3 Torus domain zf-CCCH_3 PF15663.5 EAK88132.1 - 5.7e-07 29.7 8.3 1.4e-06 28.5 8.3 1.6 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 EAK88132.1 - 1.6e-06 27.7 25.5 2.1e-06 27.4 1.9 4.8 5 1 0 5 5 5 2 CCCH-type zinc finger zf-CCCH PF00642.24 EAK88132.1 - 4.4e-06 26.5 17.1 5.8e-05 22.9 1.7 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EAK88132.1 - 1e-05 25.4 26.7 2.3e-05 24.3 5.8 4.5 3 2 0 3 3 3 2 Zinc finger domain zf-CCCH_2 PF14608.6 EAK88132.1 - 0.003 18.0 19.6 0.17 12.4 0.6 3.5 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger CLIP PF12032.8 EAK88132.1 - 0.024 14.9 1.0 0.42 10.9 0.2 2.8 2 0 0 2 2 2 0 Regulatory CLIP domain of proteinases zf-C3H1 PF10650.9 EAK88132.1 - 0.06 13.1 9.2 1.9 8.3 0.4 3.5 3 0 0 3 3 3 0 Putative zinc-finger domain Abhydrolase_1 PF00561.20 EAK88132.1 - 0.17 11.5 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Baculo_PEP_C PF04513.12 EAK88133.1 - 0.049 13.7 3.0 0.11 12.6 3.0 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus VPR PF00522.18 EAK88134.1 - 0.037 14.1 2.3 3.2 7.8 0.1 2.6 2 1 0 2 2 2 0 VPR/VPX protein I_LWEQ PF01608.17 EAK88134.1 - 0.32 11.2 0.1 0.32 11.2 0.1 2.8 2 1 1 3 3 3 0 I/LWEQ domain DUF4404 PF14357.6 EAK88134.1 - 1.6 9.4 13.7 5.5 7.7 2.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) CLZ PF16526.5 EAK88134.1 - 5.3 7.5 12.3 0.2 12.0 1.6 3.3 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ArfGap PF01412.18 EAK88135.1 - 1.1e-30 106.1 0.1 1.7e-30 105.5 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Herpes_UL52 PF03121.15 EAK88135.1 - 0.34 10.9 2.9 10 6.1 0.2 2.4 1 1 1 2 2 2 0 Herpesviridae UL52/UL70 DNA primase zf-RanBP PF00641.18 EAK88135.1 - 6 6.3 6.1 0.54 9.6 0.7 1.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Cas_Cas6 PF01881.16 EAK88136.1 - 0.0067 17.0 4.6 0.045 14.3 1.1 2.5 1 1 1 2 2 2 2 CRISPR associated protein Cas6 DUF1841 PF08897.11 EAK88136.1 - 0.0072 16.4 0.5 0.017 15.2 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1841) Mg_trans_NIPA PF05653.14 EAK88138.1 - 2.7e-21 76.0 20.0 5.6e-14 51.9 6.2 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA SieB PF14163.6 EAK88138.1 - 3.9e-06 26.4 0.2 0.0078 15.7 0.0 2.9 2 0 0 2 2 2 2 Super-infection exclusion protein B EamA PF00892.20 EAK88138.1 - 3.5 7.8 25.9 0.055 13.6 6.6 3.9 4 0 0 4 4 4 0 EamA-like transporter family DUF3139 PF11337.8 EAK88138.1 - 7 7.4 7.7 11 6.8 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3139) B-block_TFIIIC PF04182.12 EAK88140.1 - 1.6e-13 50.6 2.0 1.2e-08 35.0 0.0 3.7 2 1 0 2 2 2 2 B-block binding subunit of TFIIIC TFIIE_alpha PF02002.17 EAK88140.1 - 0.01 15.7 0.2 0.1 12.5 0.2 2.7 2 0 0 2 2 2 0 TFIIE alpha subunit ACI44 PF15270.6 EAK88140.1 - 0.026 14.7 0.6 0.14 12.4 0.1 2.5 2 0 0 2 2 2 0 Metallo-carboxypeptidase inhibitor zf-C2H2_4 PF13894.6 EAK88140.1 - 1.1 10.2 3.6 4.6 8.3 3.6 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger TLD PF07534.16 EAK88142.1 - 8.1e-30 103.9 3.8 1.8e-14 54.2 0.2 2.1 1 1 0 2 2 2 2 TLD PCI PF01399.27 EAK88143.1 - 1.2e-09 38.6 0.1 4.6e-09 36.7 0.0 2.1 2 0 0 2 2 2 1 PCI domain Histone PF00125.24 EAK88144.1 - 3e-15 56.7 0.0 3.9e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EAK88144.1 - 2.7e-10 39.8 1.1 7.6e-10 38.4 1.1 1.8 1 1 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EAK88144.1 - 0.0001 22.5 0.0 0.00014 22.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PRP1_N PF06424.12 EAK88146.1 - 6.3e-35 120.8 10.7 8.3e-35 120.4 7.2 2.7 2 1 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EAK88146.1 - 9e-17 60.3 0.0 0.55 11.2 0.0 9.6 7 1 3 10 10 10 2 Tetratricopeptide repeat TPR_19 PF14559.6 EAK88146.1 - 1e-12 48.4 0.0 0.25 11.9 0.0 8.0 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_15 PF13429.6 EAK88146.1 - 2.1e-08 33.7 0.4 0.015 14.5 0.0 5.6 2 1 2 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EAK88146.1 - 3.4e-06 26.7 2.0 0.42 10.8 0.0 7.0 8 0 0 8 8 8 1 Tetratricopeptide repeat Suf PF05843.14 EAK88146.1 - 8.1e-06 26.0 5.9 0.0002 21.5 0.3 3.9 4 1 0 5 5 5 1 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EAK88146.1 - 0.00015 21.9 4.4 21 5.8 0.0 8.2 11 0 0 11 11 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EAK88146.1 - 0.0025 17.9 0.2 1.3 9.4 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EAK88146.1 - 0.0028 17.1 0.1 0.61 9.4 0.0 3.2 2 1 1 3 3 3 1 Coatomer epsilon subunit TPR_1 PF00515.28 EAK88146.1 - 0.0081 16.0 1.5 6.4 6.8 0.0 4.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EAK88146.1 - 0.033 14.5 0.1 7.5 6.9 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EAK88146.1 - 0.13 12.0 0.0 18 5.1 0.0 4.0 4 0 0 4 4 4 0 TPR repeat Mad3_BUB1_I PF08311.12 EAK88146.1 - 0.2 11.6 2.0 5 7.1 0.1 3.9 3 1 1 4 4 4 0 Mad3/BUB1 homology region 1 UBA_3 PF09288.10 EAK88147.1 - 0.58 10.0 0.0 0.58 10.0 0.0 2.7 3 0 0 3 3 3 0 Fungal ubiquitin-associated domain ATP-synt_F PF01990.17 EAK88148.1 - 1.6e-28 98.9 0.3 1.8e-28 98.7 0.3 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit VCBS PF13517.6 EAK88150.1 - 3.3e-21 75.6 16.0 5.6e-07 30.1 0.7 6.5 5 1 0 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EAK88150.1 - 1.7e-11 44.0 13.5 0.025 14.7 0.0 5.9 5 0 0 5 5 5 5 FG-GAP repeat LRR_8 PF13855.6 EAK88151.1 - 0.0001 22.0 13.4 0.0001 22.0 13.4 4.8 4 2 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 EAK88151.1 - 0.00016 22.0 33.2 0.054 13.9 7.5 5.4 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EAK88151.1 - 0.00043 19.8 6.1 0.0049 16.4 2.7 2.9 1 1 1 2 2 2 2 Leucine-rich repeat SK_channel PF03530.14 EAK88151.1 - 0.1 12.6 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Calcium-activated SK potassium channel DUF155 PF02582.14 EAK88152.1 - 8e-36 123.8 2.5 1.4e-35 123.0 2.5 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DUF1978 PF09321.10 EAK88152.1 - 0.011 15.1 2.0 0.037 13.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) Glyco_transf_92 PF01697.27 EAK88153.1 - 4.9e-22 78.8 4.5 1.3e-21 77.4 4.5 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 EAK88153.1 - 1.7e-05 25.2 0.0 4.4e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 CAF1C_H4-bd PF12265.8 EAK88156.1 - 6.4e-23 80.8 2.5 3.5e-22 78.5 0.7 2.6 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EAK88156.1 - 1.9e-18 66.5 14.2 0.0022 18.8 1.7 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88156.1 - 0.00035 20.8 0.1 3.3 8.1 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EAK88156.1 - 0.0057 16.6 10.3 4 7.3 0.3 4.5 2 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A Choline_kinase PF01633.20 EAK88157.1 - 9.8e-43 146.2 1.8 9.8e-43 146.2 1.8 1.5 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EAK88157.1 - 0.0021 18.0 0.0 0.0035 17.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Thioredoxin PF00085.20 EAK88158.1 - 1.5e-14 53.8 0.1 2.3e-14 53.2 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EAK88158.1 - 0.00094 19.6 0.6 0.0052 17.2 0.6 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EAK88158.1 - 0.017 15.4 1.0 0.031 14.6 0.4 1.9 2 1 0 2 2 2 0 Thioredoxin-like Thioredoxin_7 PF13899.6 EAK88158.1 - 0.028 14.6 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like HTH_48 PF17906.1 EAK88158.1 - 0.11 12.7 0.5 3.8 7.7 0.0 2.9 3 0 0 3 3 3 0 HTH domain in Mos1 transposase AhpC-TSA PF00578.21 EAK88158.1 - 0.13 12.2 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_3 PF13192.6 EAK88158.1 - 0.15 12.1 0.0 0.38 10.8 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin domain TIP49 PF06068.13 EAK88159.1 - 5.3e-153 509.3 3.0 5.3e-153 509.3 3.0 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 EAK88159.1 - 7.6e-22 77.2 1.7 1.9e-21 76.0 1.7 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EAK88159.1 - 3.9e-11 43.5 0.4 2.6e-07 31.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EAK88159.1 - 3.9e-08 33.2 2.2 7.7e-05 22.5 0.1 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EAK88159.1 - 1.4e-06 28.3 0.4 0.0023 17.9 0.0 2.9 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) DnaB_C PF03796.15 EAK88159.1 - 2.5e-06 27.0 0.4 6.1e-06 25.8 0.4 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EAK88159.1 - 6.7e-06 26.6 0.3 2.4e-05 24.8 0.3 2.0 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EAK88159.1 - 2.9e-05 23.6 1.4 0.0077 15.6 0.3 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 EAK88159.1 - 7.1e-05 23.2 0.9 0.00025 21.5 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EAK88159.1 - 9.4e-05 22.8 2.4 0.0021 18.4 2.4 2.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EAK88159.1 - 0.00012 22.3 0.1 0.75 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EAK88159.1 - 0.00013 21.7 0.3 0.1 12.3 0.1 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 EAK88159.1 - 0.0004 20.0 0.0 0.00096 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EAK88159.1 - 0.00052 19.3 0.1 0.0015 17.8 0.1 1.8 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 EAK88159.1 - 0.00067 19.5 0.1 0.038 13.8 0.1 2.8 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein DUF2075 PF09848.9 EAK88159.1 - 0.00095 18.5 0.0 0.0024 17.2 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 EAK88159.1 - 0.0024 17.2 2.5 0.0039 16.6 1.6 1.8 1 1 1 2 2 2 1 KaiC NACHT PF05729.12 EAK88159.1 - 0.0025 17.8 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DNA_pol3_delta2 PF13177.6 EAK88159.1 - 0.0044 16.8 0.3 0.098 12.4 0.0 2.6 3 0 0 3 3 3 1 DNA polymerase III, delta subunit AAA_28 PF13521.6 EAK88159.1 - 0.0062 16.8 0.1 0.087 13.1 0.1 2.5 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 EAK88159.1 - 0.0084 15.2 0.1 0.014 14.5 0.1 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 TFIID-31kDa PF02291.15 EAK88159.1 - 0.012 15.6 0.7 0.028 14.5 0.7 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit AAA_30 PF13604.6 EAK88159.1 - 0.012 15.3 0.4 0.24 11.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EAK88159.1 - 0.014 15.4 0.1 0.036 14.1 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIF1 PF05970.14 EAK88159.1 - 0.016 14.4 0.2 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase IstB_IS21 PF01695.17 EAK88159.1 - 0.016 14.9 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EAK88159.1 - 0.018 15.5 2.1 0.039 14.5 0.1 2.6 3 1 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EAK88159.1 - 0.021 14.4 0.2 0.15 11.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EAK88159.1 - 0.054 13.9 0.0 0.19 12.1 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_23 PF13476.6 EAK88159.1 - 0.17 12.4 5.8 0.33 11.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EAK88159.1 - 0.65 10.0 3.9 4.5 7.2 0.1 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Glycos_transf_2 PF00535.26 EAK88160.1 - 9.4e-29 100.4 0.0 1.8e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EAK88160.1 - 8e-19 68.1 2.0 1.2e-18 67.6 2.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EAK88160.1 - 4.3e-08 32.7 0.2 8.6e-08 31.7 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EAK88160.1 - 0.0026 17.3 0.0 0.0061 16.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PPR_2 PF13041.6 EAK88160.1 - 0.14 12.4 0.1 0.37 11.0 0.1 1.6 1 0 0 1 1 1 0 PPR repeat family Ank_2 PF12796.7 EAK88161.1 - 7.3e-35 119.4 2.4 1.3e-14 54.6 0.1 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK88161.1 - 5.9e-20 71.4 0.9 3.9e-09 36.9 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAK88161.1 - 3.7e-18 63.7 0.3 7.6e-05 22.8 0.0 4.3 5 0 0 5 5 5 3 Ankyrin repeat Bromodomain PF00439.25 EAK88161.1 - 3.2e-17 62.4 0.2 7e-17 61.3 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Ank_5 PF13857.6 EAK88161.1 - 9.7e-15 54.5 4.4 1.9e-08 34.4 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EAK88161.1 - 9e-12 44.9 0.0 0.01 16.3 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat DNA_pol3_tau_5 PF12170.8 EAK88161.1 - 0.029 14.4 0.2 0.06 13.4 0.2 1.5 1 0 0 1 1 1 0 DNA polymerase III tau subunit V interacting with alpha MSG PF02349.15 EAK88161.1 - 1 9.6 4.2 1.1 9.5 0.1 2.7 2 1 0 2 2 2 0 Major surface glycoprotein Actin PF00022.19 EAK88162.1 - 4.8e-40 137.4 0.0 7.5e-40 136.8 0.0 1.3 1 1 0 1 1 1 1 Actin DUF1279 PF06916.13 EAK88163.1 - 2.3e-22 79.4 1.2 3.5e-22 78.7 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DUF5102 PF17104.5 EAK88164.1 - 0.029 14.4 3.4 0.065 13.3 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) CsgA PF17334.2 EAK88164.1 - 9.9 7.0 9.1 0.81 10.5 0.5 3.5 3 0 0 3 3 3 0 Minor curli fiber component A Transp_cyt_pur PF02133.15 EAK88165.1 - 0.014 14.2 0.0 0.017 13.9 0.0 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin YajC PF02699.15 EAK88165.1 - 0.31 11.0 4.0 0.51 10.3 3.2 1.8 2 0 0 2 2 2 0 Preprotein translocase subunit Symplekin_C PF12295.8 EAK88166.1 - 1.9e-33 116.1 1.4 6.3e-33 114.4 0.5 2.5 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal ATP_bind_3 PF01171.20 EAK88167.1 - 2.6e-16 59.9 0.0 3.9e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EAK88167.1 - 4.7e-08 32.4 2.3 4.7e-08 32.4 2.3 2.2 2 0 0 2 2 2 1 Zinc-ribbon PAPS_reduct PF01507.19 EAK88167.1 - 0.00072 19.6 0.0 0.0034 17.5 0.0 1.9 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family RecR PF02132.15 EAK88167.1 - 0.76 9.4 6.7 0.61 9.7 3.6 2.3 2 0 0 2 2 2 0 RecR protein tRNA_m1G_MT PF01746.21 EAK88168.1 - 8.5e-14 51.7 0.2 1.4e-13 51.0 0.2 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Methyltransf_12 PF08242.12 EAK88169.1 - 0.57 11.0 2.5 14 6.5 0.3 2.2 2 0 0 2 2 2 0 Methyltransferase domain Syntaxin-6_N PF09177.11 EAK88169.1 - 0.67 10.5 4.1 3.9 8.1 4.1 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal RPN13_C PF16550.5 EAK88170.1 - 2.4e-22 79.2 0.5 3.5e-22 78.7 0.5 1.3 1 0 0 1 1 1 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 EAK88170.1 - 4.1e-11 43.3 0.2 6.7e-11 42.6 0.2 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DUF2853 PF11015.8 EAK88170.1 - 0.045 14.4 0.0 0.19 12.4 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2853) GAT PF03127.14 EAK88170.1 - 0.078 13.3 6.7 0.2 12.0 1.1 2.6 1 1 1 2 2 2 0 GAT domain AKNA PF12443.8 EAK88170.1 - 0.14 12.8 0.5 0.26 12.0 0.5 1.5 1 0 0 1 1 1 0 AT-hook-containing transcription factor RNase_HII PF01351.18 EAK88170.1 - 2.8 7.7 4.8 2.6 7.8 3.7 1.5 1 1 0 1 1 1 0 Ribonuclease HII Peptidase_S9 PF00326.21 EAK88171.1 - 1.9e-07 30.8 0.0 1.3e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EAK88171.1 - 0.00011 21.6 0.0 0.43 9.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EAK88171.1 - 0.00084 19.2 0.4 0.08 12.7 0.0 2.7 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EAK88171.1 - 0.0031 17.2 0.0 0.007 16.0 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DUF1749 PF08538.10 EAK88171.1 - 0.0085 15.2 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_1 PF00561.20 EAK88171.1 - 0.011 15.4 0.7 0.49 10.0 0.0 2.3 2 1 0 2 2 2 0 alpha/beta hydrolase fold SET PF00856.28 EAK88172.1 - 5.8e-21 75.6 8.8 3.1e-20 73.3 0.6 2.7 2 0 0 2 2 2 2 SET domain PHD PF00628.29 EAK88172.1 - 1.3e-06 28.1 23.6 7.7e-06 25.7 6.9 7.1 7 1 0 7 7 7 4 PHD-finger FokI_C PF02980.16 EAK88172.1 - 0.025 14.6 0.4 0.065 13.3 0.4 1.7 1 0 0 1 1 1 0 Restriction endonuclease FokI, catalytic domain Rad51 PF08423.11 EAK88173.1 - 6.9e-120 399.1 0.1 8.4e-120 398.8 0.1 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EAK88173.1 - 4.7e-11 42.7 0.0 7.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EAK88173.1 - 1.5e-08 34.4 0.0 2.3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EAK88173.1 - 1.8e-05 24.2 1.3 9.4e-05 21.9 1.3 2.2 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 EAK88173.1 - 4.1e-05 24.1 0.0 0.0001 22.8 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF3853 PF12964.7 EAK88173.1 - 0.019 15.2 0.1 0.096 12.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) AAA_24 PF13479.6 EAK88173.1 - 0.019 14.7 0.0 0.035 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain PPC PF04151.15 EAK88175.1 - 2.1 9.5 7.7 4.3 8.5 0.9 2.6 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain Phage_TAC_6 PF09550.10 EAK88176.1 - 0.0068 16.8 9.4 49 4.5 0.1 7.4 8 0 0 8 8 8 1 Phage tail assembly chaperone protein, TAC BAMBI PF06211.12 EAK88176.1 - 0.021 15.1 0.3 26 5.1 0.0 4.4 4 0 0 4 4 4 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Toprim_Crpt PF13342.6 EAK88176.1 - 1 9.4 24.3 17 5.5 0.2 7.7 8 0 0 8 8 8 0 C-terminal repeat of topoisomerase CDC50 PF03381.15 EAK88177.1 - 1.2e-53 182.4 10.0 4e-53 180.7 9.4 2.1 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family SSP160 PF06933.11 EAK88178.1 - 3.4 5.8 30.1 5.7 5.0 30.1 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ResIII PF04851.15 EAK88179.1 - 0.047 13.7 0.0 0.44 10.5 0.0 2.0 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit BBP1_C PF15272.6 EAK88179.1 - 0.26 11.1 1.1 0.29 10.9 0.1 1.5 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal TPR_8 PF13181.6 EAK88180.1 - 0.1 12.8 0.4 20 5.7 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat D5_N PF08706.11 EAK88180.1 - 0.12 12.6 4.9 0.32 11.2 0.1 3.4 3 0 0 3 3 3 0 D5 N terminal like Abhydrolase_2 PF02230.16 EAK88181.1 - 2.1e-13 50.6 0.0 3.2e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 EAK88181.1 - 9.6e-06 25.3 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EAK88181.1 - 6.4e-05 22.5 0.0 0.0061 16.0 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 EAK88181.1 - 0.00015 20.5 0.0 0.00045 19.0 0.0 1.8 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 EAK88181.1 - 0.0026 17.0 0.0 0.0062 15.8 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EAK88181.1 - 0.015 15.2 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EAK88181.1 - 0.072 13.0 0.0 0.72 9.7 0.0 2.3 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.20 EAK88181.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold VTC PF09359.10 EAK88182.1 - 3.3e-98 328.5 2.9 3.3e-98 328.5 2.9 3.4 4 0 0 4 4 4 1 VTC domain DUF202 PF02656.15 EAK88182.1 - 0.00073 19.9 2.0 0.00092 19.6 0.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EAK88182.1 - 0.0029 17.6 0.1 0.0029 17.6 0.1 2.8 3 1 0 3 3 3 1 SPX domain DUF1282 PF06930.12 EAK88182.1 - 0.02 14.7 0.3 0.039 13.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) Qua1 PF16274.5 EAK88182.1 - 0.037 13.9 0.3 0.15 11.9 0.3 2.2 1 0 0 1 1 1 0 Qua1 domain F-box PF00646.33 EAK88183.1 - 0.04 13.8 0.2 0.27 11.2 0.0 2.6 2 0 0 2 2 2 0 F-box domain CCAP PF11105.8 EAK88183.1 - 0.089 12.7 0.5 0.2 11.6 0.5 1.6 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a Jagunal PF07086.12 EAK88184.1 - 0.32 11.0 8.4 0.056 13.5 4.2 1.7 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis MFS_1 PF07690.16 EAK88185.1 - 0.011 14.7 10.6 0.0065 15.4 8.0 1.5 1 1 1 2 2 2 0 Major Facilitator Superfamily MFS_3 PF05977.13 EAK88185.1 - 0.028 12.8 1.7 0.1 10.9 0.8 1.9 2 0 0 2 2 2 0 Transmembrane secretion effector AATF-Che1 PF13339.6 EAK88185.1 - 0.25 12.0 4.8 0.4 11.4 4.8 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor RSRP PF17069.5 EAK88187.1 - 0.0079 15.8 23.0 0.015 14.9 23.0 1.3 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 Chorion_2 PF03964.15 EAK88187.1 - 0.13 13.1 7.1 0.28 12.0 7.1 1.4 1 0 0 1 1 1 0 Chorion family 2 DUF1664 PF07889.12 EAK88187.1 - 8.7 6.4 10.8 4.4 7.3 1.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) tRNA_anti-codon PF01336.25 EAK88188.1 - 8.6e-08 32.1 0.2 1.5e-07 31.3 0.2 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain COPR5 PF15340.6 EAK88188.1 - 0.14 12.8 1.1 0.7 10.5 0.1 2.1 2 0 0 2 2 2 0 Cooperator of PRMT5 family bZIP_C PF12498.8 EAK88188.1 - 2.8 8.9 8.9 2 9.4 2.8 2.3 2 0 0 2 2 2 0 Basic leucine-zipper C terminal Rdx PF10262.9 EAK88190.1 - 1.3e-08 34.9 0.0 2.1e-08 34.2 0.0 1.4 1 1 0 1 1 1 1 Rdx family AAA_assoc PF14363.6 EAK88190.1 - 0.038 14.3 0.0 0.078 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA NOB1_Zn_bind PF08772.11 EAK88190.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF3918 PF13056.6 EAK88190.1 - 0.36 10.5 1.2 0.52 10.0 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) tRNA_m1G_MT PF01746.21 EAK88191.1 - 1.7e-10 40.9 0.1 1.7e-10 40.9 0.1 1.6 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase Aida_N PF08910.10 EAK88191.1 - 0.15 12.4 7.4 4.4 7.8 3.6 3.2 3 0 0 3 3 3 0 Aida N-terminus DUF3043 PF11241.8 EAK88191.1 - 0.57 10.2 6.1 1.1 9.3 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Pho88 PF10032.9 EAK88193.1 - 0.029 13.6 0.2 0.029 13.6 0.2 1.5 2 0 0 2 2 2 0 Phosphate transport (Pho88) FAM176 PF14851.6 EAK88193.1 - 0.085 12.5 0.2 0.085 12.5 0.2 2.0 2 0 0 2 2 2 0 FAM176 family Presenilin PF01080.17 EAK88193.1 - 0.22 10.2 3.9 0.28 9.9 3.9 1.2 1 0 0 1 1 1 0 Presenilin Kei1 PF08552.11 EAK88193.1 - 0.29 11.0 0.2 0.29 11.0 0.2 2.9 2 1 1 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 EOS1 PF12326.8 EAK88193.1 - 1.1 9.1 7.0 0.17 11.8 2.0 1.9 2 0 0 2 2 2 0 N-glycosylation protein Serinc PF03348.15 EAK88193.1 - 2.2 7.1 5.1 2.6 6.9 5.1 1.3 1 1 0 1 1 1 0 Serine incorporator (Serinc) Mem_trans PF03547.18 EAK88193.1 - 2.6 6.4 4.3 0.8 8.0 1.4 1.5 1 1 0 2 2 2 0 Membrane transport protein DUF4834 PF16118.5 EAK88193.1 - 3 8.9 12.6 0.37 11.8 3.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) YMF19 PF02326.15 EAK88193.1 - 5.4 7.9 7.7 0.7 10.7 1.4 2.1 2 0 0 2 2 2 0 Plant ATP synthase F0 Connexin PF00029.19 EAK88193.1 - 7.4 6.2 9.3 0.55 10.0 2.8 1.9 1 1 0 2 2 2 0 Connexin MAP17 PF15807.5 EAK88193.1 - 9.7 6.4 8.9 1.1 9.5 1.3 2.1 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SNF2_N PF00176.23 EAK88194.1 - 4.5e-27 94.7 1.9 3.5e-26 91.8 1.9 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK88194.1 - 4e-12 46.5 0.0 5.3e-11 42.9 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK88194.1 - 1.8e-08 34.5 1.2 8.9e-08 32.3 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EAK88194.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Ribosomal_L18_c PF14204.6 EAK88194.1 - 3.4 8.7 7.6 33 5.5 2.3 3.5 3 0 0 3 3 3 0 Ribosomal L18 C-terminal region C2 PF00168.30 EAK88195.1 - 2.8e-27 95.0 0.0 3.2e-07 30.6 0.0 6.3 6 0 0 6 6 6 5 C2 domain PI3K_C2 PF00792.24 EAK88195.1 - 0.0088 16.0 0.0 0.15 12.0 0.0 2.6 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 Spp-24 PF07448.11 EAK88195.1 - 0.087 13.0 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain FerI PF08151.12 EAK88195.1 - 0.12 12.5 0.6 3.9 7.6 0.0 3.0 2 0 0 2 2 2 0 FerI (NUC094) domain Ferlin_C PF16165.5 EAK88195.1 - 0.41 10.6 0.0 0.41 10.6 0.0 2.1 3 0 0 3 3 3 0 Ferlin C-terminus DNA_pol_A_exo1 PF01612.20 EAK88196.1 - 1.6e-37 128.9 0.1 2.9e-37 128.1 0.1 1.4 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 EAK88196.1 - 1.8e-07 31.0 0.0 4.5e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 HRDC domain PEPcase PF00311.17 EAK88198.1 - 1.4e-222 741.1 0.0 1.4e-134 450.0 0.0 3.1 3 0 0 3 3 3 3 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 EAK88198.1 - 0.0003 19.4 0.0 0.00087 17.9 0.0 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate carboxylase HpcH_HpaI PF03328.14 EAK88198.1 - 0.018 14.2 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family LOH1CR12 PF10158.9 EAK88198.1 - 0.38 10.8 4.5 0.27 11.2 0.1 3.0 4 0 0 4 4 4 0 Tumour suppressor protein EF-hand_1 PF00036.32 EAK88199.1 - 1.7e-31 105.4 11.9 7.4e-08 31.4 1.9 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAK88199.1 - 2.6e-28 98.3 9.1 3.6e-14 53.0 3.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK88199.1 - 2.5e-25 86.2 8.1 3.4e-07 29.7 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EAK88199.1 - 4.3e-17 61.7 6.7 1.3e-09 37.8 1.1 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EAK88199.1 - 8.4e-14 51.6 0.3 1.1e-05 25.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EAK88199.1 - 9.1e-10 37.6 10.9 0.00085 18.7 1.7 4.6 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 EAK88199.1 - 5.6e-05 23.0 3.2 0.17 11.9 0.0 2.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EAK88199.1 - 0.0001 22.6 2.1 0.21 12.0 0.4 2.8 1 1 1 2 2 2 2 EF-hand domain Caleosin PF05042.13 EAK88199.1 - 0.00072 19.5 0.3 2.8 7.8 0.0 3.7 1 1 3 4 4 4 1 Caleosin related protein DUF1636 PF07845.11 EAK88199.1 - 0.0038 17.7 0.0 0.16 12.4 0.0 3.0 1 1 3 4 4 4 1 Protein of unknown function (DUF1636) EF-hand_11 PF08976.11 EAK88199.1 - 0.0061 17.4 0.9 1.3 9.9 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain Gp-FAR-1 PF05823.12 EAK88199.1 - 0.0066 16.8 4.2 0.16 12.3 0.1 2.8 2 1 1 3 3 3 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SurA_N_2 PF13623.6 EAK88199.1 - 0.0098 15.8 2.5 1.1 9.2 0.1 2.7 1 1 1 2 2 2 2 SurA N-terminal domain HTH_40 PF14493.6 EAK88199.1 - 0.035 14.5 4.0 2.7 8.5 0.3 2.5 1 1 1 2 2 2 0 Helix-turn-helix domain DUF4214 PF13946.6 EAK88199.1 - 0.039 14.0 0.0 0.66 10.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4214) Mst1_SARAH PF11629.8 EAK88199.1 - 0.044 13.9 2.7 0.16 12.0 2.7 2.0 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Ribosomal_L12 PF00542.19 EAK88199.1 - 0.073 13.4 2.7 0.17 12.2 0.1 2.6 2 1 1 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain PhetRS_B1 PF18262.1 EAK88199.1 - 0.19 12.0 0.4 0.19 12.0 0.4 2.0 2 1 1 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain TerB PF05099.13 EAK88199.1 - 0.27 11.2 4.7 7.6 6.5 0.1 2.8 1 1 1 3 3 3 0 Tellurite resistance protein TerB EF-hand_10 PF14788.6 EAK88199.1 - 0.28 11.1 4.1 0.41 10.5 0.1 2.4 2 0 0 2 2 2 0 EF hand MgtE_N PF03448.17 EAK88199.1 - 1.1 9.9 7.0 0.25 11.9 1.2 2.3 2 1 0 2 2 2 0 MgtE intracellular N domain Yae1_N PF09811.9 EAK88201.1 - 0.0089 15.7 10.7 0.022 14.5 10.7 1.7 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Alpha_GJ PF03229.13 EAK88203.1 - 0.094 13.3 1.7 0.19 12.3 1.7 1.4 1 0 0 1 1 1 0 Alphavirus glycoprotein J Med6 PF04934.14 EAK88203.1 - 0.28 11.0 2.1 0.35 10.6 0.2 2.1 2 0 0 2 2 2 0 MED6 mediator sub complex component Ribosomal_S13_N PF08069.12 EAK88204.1 - 9.6e-28 96.0 0.2 1.8e-27 95.2 0.2 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EAK88204.1 - 9.6e-14 51.4 0.9 1.3e-13 51.0 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 IMS_C PF11799.8 EAK88204.1 - 0.051 14.3 0.2 0.1 13.3 0.2 1.7 1 1 0 1 1 1 0 impB/mucB/samB family C-terminal domain LSM PF01423.22 EAK88205.1 - 8.6e-17 60.6 3.0 1.1e-16 60.2 3.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EAK88205.1 - 0.0027 17.8 0.1 0.0037 17.4 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain RBP_receptor PF14752.6 EAK88205.1 - 0.036 12.6 0.1 0.047 12.3 0.1 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor Gemin7 PF11095.8 EAK88205.1 - 0.046 13.6 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) THDPS_M PF14789.6 EAK88206.1 - 0.056 13.5 0.0 6.9 6.8 0.0 2.6 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase middle DAD PF02109.16 EAK88208.1 - 3e-26 91.9 3.7 4.6e-26 91.3 3.7 1.2 1 0 0 1 1 1 1 DAD family Band_7 PF01145.25 EAK88209.1 - 5.5e-23 81.9 0.7 7.2e-23 81.5 0.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 EAK88209.1 - 0.077 13.2 1.7 0.15 12.2 1.7 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 Sin3_corepress PF08295.12 EAK88210.1 - 5.9e-36 122.5 0.2 2.2e-35 120.7 0.2 2.1 1 0 0 1 1 1 1 Sin3 family co-repressor PAH PF02671.21 EAK88210.1 - 4.5e-23 81.1 7.1 2.4e-11 43.6 0.4 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3a_C PF16879.5 EAK88210.1 - 2.7e-21 76.5 1.3 6.4e-20 72.0 0.2 3.4 2 1 0 2 2 2 1 C-terminal domain of Sin3a protein Nas2_N PF18265.1 EAK88211.1 - 4.2e-29 100.3 0.0 7.4e-29 99.5 0.0 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 EAK88211.1 - 3.3e-05 23.6 0.0 6.3e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EAK88211.1 - 0.0013 19.0 0.0 0.0034 17.7 0.0 1.6 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.24 EAK88211.1 - 0.033 14.5 0.0 0.068 13.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DUF1048 PF06304.11 EAK88211.1 - 0.068 13.6 0.1 0.15 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) GRASP55_65 PF04495.14 EAK88211.1 - 0.17 12.2 0.0 2.2 8.6 0.0 2.2 1 1 0 1 1 1 0 GRASP55/65 PDZ-like domain Beta-lactamase PF00144.24 EAK88212.1 - 1.5e-27 96.7 0.0 9.9e-27 94.0 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase Peptidase_S49_N PF08496.10 EAK88212.1 - 0.35 10.9 2.9 0.73 9.9 2.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Erf4 PF10256.9 EAK88212.1 - 8.7 6.5 8.0 1.2 9.3 2.2 2.6 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family Prefoldin PF02996.17 EAK88213.1 - 2.6e-20 72.5 2.4 3.8e-20 72.0 2.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF4988 PF16378.5 EAK88213.1 - 0.017 14.8 3.6 0.25 11.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function Rab_bind PF16704.5 EAK88213.1 - 0.028 14.4 0.2 0.071 13.2 0.2 1.6 1 0 0 1 1 1 0 Rab binding domain Fib_alpha PF08702.10 EAK88213.1 - 0.039 14.1 0.8 0.039 14.1 0.8 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family IFT20 PF14931.6 EAK88213.1 - 0.05 13.8 8.2 0.5 10.6 0.3 2.2 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Flu_NS2 PF00601.19 EAK88213.1 - 0.27 11.6 2.9 0.63 10.4 0.5 2.2 3 0 0 3 3 3 0 Influenza non-structural protein (NS2) DUF4041 PF13250.6 EAK88213.1 - 0.62 10.0 5.0 3.3 7.7 2.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4041) ubiquitin PF00240.23 EAK88214.1 - 3.7e-105 343.8 10.1 3e-34 116.6 0.3 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 EAK88214.1 - 5.7e-51 170.2 10.7 3.2e-16 58.9 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EAK88214.1 - 2.8e-20 72.6 3.6 5.7e-05 23.5 0.1 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EAK88214.1 - 2.1e-12 46.8 2.5 0.014 15.3 0.1 3.4 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EAK88214.1 - 7.8e-12 45.3 1.0 0.045 13.9 0.0 3.9 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EAK88214.1 - 2.2e-11 44.0 3.3 0.03 14.7 0.1 3.1 3 0 0 3 3 3 3 Ubiquitin-like domain DUF2407 PF10302.9 EAK88214.1 - 3.6e-09 37.1 0.1 0.36 11.4 0.0 3.2 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EAK88214.1 - 1.7e-06 27.9 0.0 1.7 8.4 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EAK88214.1 - 6.3e-06 26.1 14.1 18 5.5 0.0 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain UDP-g_GGTase PF06427.11 EAK88214.1 - 0.00024 21.2 1.5 3.7 7.7 0.0 3.4 4 0 0 4 4 3 2 UDP-glucose:Glycoprotein Glucosyltransferase DUF2870 PF11069.8 EAK88214.1 - 0.00028 21.2 0.1 22 5.5 0.0 3.8 3 3 0 3 3 3 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EAK88214.1 - 0.00077 18.9 0.1 1.3 8.3 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase RBD PF02196.15 EAK88214.1 - 0.00095 19.2 0.0 24 5.1 0.0 3.4 3 0 0 3 3 3 0 Raf-like Ras-binding domain DUF3861 PF12977.7 EAK88214.1 - 0.0025 17.9 0.5 29 4.9 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF969 PF06149.12 EAK88214.1 - 0.0081 15.6 0.0 15 4.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) TraK PF06586.11 EAK88214.1 - 0.011 15.5 0.2 11 5.6 0.0 3.1 3 0 0 3 3 3 0 TraK protein FlgD_ig PF13860.6 EAK88214.1 - 0.021 14.7 2.3 41 4.1 0.1 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain Big_7 PF17957.1 EAK88214.1 - 0.024 15.4 0.0 91 3.9 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain CorA PF01544.18 EAK88214.1 - 0.057 12.7 0.1 48 3.1 0.0 3.0 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein GDYXXLXY PF14345.6 EAK88214.1 - 0.061 13.1 0.1 83 3.0 0.0 3.2 3 0 0 3 3 3 0 GDYXXLXY protein Phage_sheath_1N PF17481.2 EAK88214.1 - 0.062 13.8 1.6 26 5.4 0.4 3.0 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain ORF11CD3 PF10549.9 EAK88214.1 - 0.074 13.2 0.0 66 3.7 0.0 3.6 3 0 0 3 3 3 0 ORF11CD3 domain ProRS-C_2 PF09181.10 EAK88214.1 - 0.1 12.7 1.1 95 3.2 0.0 3.1 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal DMA PF03474.14 EAK88214.1 - 0.5 10.0 1.7 1.2e+02 2.4 0.0 3.3 3 0 0 3 3 3 0 DMRTA motif PI3K_p85B PF02192.16 EAK88214.1 - 1.5 8.6 3.4 1.2e+02 2.5 0.1 3.2 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Peptidase_M17 PF00883.21 EAK88215.1 - 5.3e-99 331.4 0.0 6.7e-99 331.1 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain His_Phos_1 PF00300.22 EAK88216.1 - 3.3e-30 105.2 0.1 9.5e-30 103.7 0.1 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Med6 PF04934.14 EAK88217.1 - 4.6e-12 45.9 0.0 7.1e-12 45.3 0.0 1.4 1 1 0 1 1 1 1 MED6 mediator sub complex component Pkinase PF00069.25 EAK88218.1 - 6e-80 268.4 0.0 6.7e-80 268.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88218.1 - 3.4e-35 121.6 0.0 4.5e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EAK88218.1 - 6.9e-05 22.0 0.1 0.00056 19.0 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EAK88218.1 - 0.00013 22.0 0.0 0.03 14.3 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EAK88218.1 - 0.00013 21.4 0.0 0.00025 20.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EAK88218.1 - 0.012 15.2 0.3 0.044 13.4 0.1 1.7 1 1 1 2 2 2 0 RIO1 family Kdo PF06293.14 EAK88218.1 - 0.039 13.3 0.8 0.1 12.0 0.8 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EAK88218.1 - 0.081 12.5 0.2 0.64 9.6 0.1 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 EAK88218.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 ADH_N PF08240.12 EAK88219.1 - 4.1e-28 97.4 5.6 7.9e-28 96.5 5.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EAK88219.1 - 3.2e-19 69.2 0.3 6.7e-19 68.2 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EAK88219.1 - 2e-06 28.9 0.0 3.8e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EAK88219.1 - 0.0097 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EAK88219.1 - 0.015 15.4 0.1 0.046 13.9 0.1 1.8 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EAK88219.1 - 0.044 13.7 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EAK88219.1 - 0.057 12.7 0.2 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Arf PF00025.21 EAK88220.1 - 1.3e-11 44.2 0.0 1.7e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family T2SSE PF00437.20 EAK88220.1 - 0.00018 20.7 0.2 0.00024 20.3 0.2 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EAK88220.1 - 0.0013 18.8 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EAK88220.1 - 0.0028 17.1 0.1 0.0053 16.2 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EAK88220.1 - 0.017 15.3 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EAK88220.1 - 0.035 14.6 0.1 0.072 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 EAK88220.1 - 0.053 13.1 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 Ras family cobW PF02492.19 EAK88220.1 - 0.063 12.9 0.3 0.13 11.8 0.2 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EAK88220.1 - 0.07 12.9 1.1 0.15 11.8 1.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EAK88220.1 - 0.11 13.0 0.5 0.3 11.6 0.4 1.8 2 1 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EAK88220.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 EAK88220.1 - 0.19 11.1 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Cofilin_ADF PF00241.20 EAK88221.1 - 9.3e-28 96.5 0.1 1e-27 96.3 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Alpha-amylase PF00128.24 EAK88222.1 - 6.2e-51 173.9 2.6 1.1e-50 173.1 2.6 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EAK88222.1 - 0.019 15.1 0.0 0.038 14.1 0.0 1.5 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain Glyco_hydro_70 PF02324.16 EAK88222.1 - 0.02 13.1 0.0 0.22 9.6 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolase family 70 HTH_Tnp_Tc5 PF03221.16 EAK88222.1 - 0.046 13.8 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DnaJ PF00226.31 EAK88223.1 - 7.9e-24 83.6 0.8 3.2e-23 81.6 0.8 2.2 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 EAK88223.1 - 1.3e-09 38.2 14.3 7.3e-09 35.7 7.6 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EAK88223.1 - 6.9e-08 32.6 7.4 6.9e-08 32.6 7.4 3.4 3 0 0 3 3 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EAK88223.1 - 1.9e-07 31.3 8.7 0.00014 22.2 1.7 4.5 5 0 0 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EAK88223.1 - 3.7e-07 30.4 6.1 0.0045 17.7 1.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EAK88223.1 - 1.3e-05 25.4 9.5 0.0025 18.2 3.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-UBP PF02148.19 EAK88223.1 - 0.027 14.8 1.6 0.14 12.5 0.3 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein zf-C2H2_6 PF13912.6 EAK88223.1 - 0.041 13.9 7.1 0.76 9.9 1.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-LYAR PF08790.11 EAK88223.1 - 0.085 12.8 4.1 0.21 11.5 0.9 2.9 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Mut7-C PF01927.16 EAK88223.1 - 0.11 12.6 7.2 3.1 7.9 3.5 2.5 2 0 0 2 2 2 0 Mut7-C RNAse domain zf-BED PF02892.15 EAK88223.1 - 0.63 10.1 8.2 6.3 6.9 0.8 3.4 3 0 0 3 3 3 0 BED zinc finger DUF4379 PF14311.6 EAK88223.1 - 4.5 7.7 8.5 4.1 7.8 0.2 4.1 4 0 0 4 4 4 0 Probable Zinc-ribbon domain zf-H2C2_2 PF13465.6 EAK88223.1 - 6.9 7.3 8.3 1.2 9.7 1.0 3.0 3 0 0 3 3 3 0 Zinc-finger double domain Plus-3 PF03126.18 EAK88224.1 - 1.5e-09 38.3 0.5 8e-09 36.0 0.0 2.6 2 0 0 2 2 2 1 Plus-3 domain DUF4041 PF13250.6 EAK88224.1 - 0.044 13.7 2.7 0.23 11.4 0.4 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) Ribosomal_S7e PF01251.18 EAK88225.1 - 9.9e-60 201.4 0.1 1.1e-59 201.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e FANCD2OS PF15124.6 EAK88225.1 - 0.14 12.4 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 FANCD2 opposite strand protein Histone PF00125.24 EAK88226.1 - 5.2e-16 59.2 2.6 6.2e-16 59.0 2.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EAK88226.1 - 6.7e-06 26.3 0.8 1.4e-05 25.3 0.8 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1804 PF08822.11 EAK88226.1 - 0.0049 16.9 0.9 0.0062 16.5 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1804) TFIID_20kDa PF03847.13 EAK88226.1 - 0.008 16.6 0.0 0.015 15.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DltD PF04914.12 EAK88226.1 - 0.022 14.2 2.8 0.026 13.9 2.8 1.0 1 0 0 1 1 1 0 DltD protein Glyco_transf_8 PF01501.20 EAK88227.1 - 1.8e-14 53.9 2.1 2.2e-14 53.6 2.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 WD40 PF00400.32 EAK88228.1 - 3.5e-06 27.6 5.9 0.0022 18.8 0.4 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88228.1 - 0.0044 17.3 0.2 1.2 9.5 0.0 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EAK88228.1 - 0.069 13.2 0.1 3.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region vATP-synt_AC39 PF01992.16 EAK88229.1 - 1.5e-89 300.8 4.1 2.2e-89 300.3 4.1 1.1 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit ADK PF00406.22 EAK88230.1 - 4.7e-53 179.3 0.0 5.8e-53 179.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EAK88230.1 - 6.1e-25 88.2 0.0 1.2e-24 87.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EAK88230.1 - 4.6e-16 58.5 0.1 9.6e-16 57.5 0.1 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 EAK88230.1 - 4.3e-06 27.2 0.4 0.0002 21.7 0.0 2.1 1 1 1 2 2 2 1 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 EAK88230.1 - 0.00053 20.5 0.0 0.0022 18.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EAK88230.1 - 0.00091 19.4 0.0 0.0041 17.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EAK88230.1 - 0.024 14.0 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Thymidylate_kin PF02223.17 EAK88230.1 - 0.12 12.0 0.0 2.5 7.7 0.1 2.5 3 0 0 3 3 3 0 Thymidylate kinase Cytidylate_kin PF02224.18 EAK88230.1 - 0.19 11.4 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase TFIIB PF00382.19 EAK88231.1 - 1.5e-23 82.7 0.3 6.4e-11 42.1 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EAK88231.1 - 2.8e-17 62.9 4.8 2.8e-17 62.9 4.8 2.3 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EAK88231.1 - 3e-11 42.6 1.5 1e-10 40.9 1.5 2.0 1 0 0 1 1 1 1 TFIIB zinc-binding zf-RRN7 PF11781.8 EAK88231.1 - 0.0044 16.7 0.6 0.0094 15.6 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DZR PF12773.7 EAK88231.1 - 0.06 13.4 1.2 0.15 12.1 1.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EAK88231.1 - 0.94 9.0 4.8 7.1 6.2 4.8 2.4 1 1 0 1 1 1 0 zinc-ribbon domain DnaJ PF00226.31 EAK88232.1 - 2.5e-19 69.2 1.3 4.7e-19 68.3 0.2 1.9 2 0 0 2 2 2 1 DnaJ domain Methyltr_RsmB-F PF01189.17 EAK88233.1 - 2.3e-32 112.3 0.0 4e-30 105.0 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EAK88233.1 - 0.018 15.1 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Transketolase_C PF02780.20 EAK88233.1 - 0.19 11.6 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Transketolase, C-terminal domain DUF4193 PF13834.6 EAK88233.1 - 0.51 10.9 2.3 0.57 10.7 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) Enolase_C PF00113.22 EAK88234.1 - 2.8e-139 463.4 0.0 3.5e-139 463.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EAK88234.1 - 1.2e-54 184.0 0.0 1.8e-54 183.4 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EAK88234.1 - 7.9e-10 38.7 0.0 1.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like PH PF00169.29 EAK88235.1 - 1.3e-19 70.7 0.4 1.6e-19 70.4 0.4 1.0 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EAK88235.1 - 6.7e-06 26.1 0.2 1.2e-05 25.3 0.2 1.4 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 EAK88235.1 - 2.9e-05 24.3 0.1 4.2e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EAK88235.1 - 0.00019 21.8 2.8 0.0021 18.5 2.8 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 EAK88235.1 - 0.00069 19.5 0.0 0.0011 18.8 0.0 1.3 1 1 0 1 1 1 1 Pleckstrin homology domain AAA PF00004.29 EAK88236.1 - 8.3e-84 278.6 0.0 1.8e-48 164.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAK88236.1 - 1.6e-20 72.6 0.0 3e-09 36.5 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EAK88236.1 - 3.8e-12 46.2 0.0 2.6e-05 24.0 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EAK88236.1 - 1.6e-11 44.9 0.1 6.7e-05 23.3 0.0 3.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EAK88236.1 - 1e-09 38.7 0.0 0.0011 19.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EAK88236.1 - 4.8e-09 36.6 0.4 0.019 15.2 0.0 4.9 3 2 2 5 5 5 2 AAA domain TIP49 PF06068.13 EAK88236.1 - 7.4e-09 35.3 0.1 0.0025 17.1 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_5 PF07728.14 EAK88236.1 - 1.3e-08 34.9 0.7 0.0055 16.7 0.1 3.3 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EAK88236.1 - 7.6e-08 32.2 1.8 1.3 8.5 0.0 4.4 3 1 1 4 4 4 2 AAA domain IstB_IS21 PF01695.17 EAK88236.1 - 4.7e-07 29.7 0.0 0.019 14.7 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_2 PF07724.14 EAK88236.1 - 1.4e-06 28.5 0.1 0.00027 21.1 0.0 3.3 3 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EAK88236.1 - 5.2e-06 26.5 0.0 0.0038 17.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EAK88236.1 - 8.3e-06 26.1 0.0 0.018 15.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 EAK88236.1 - 8.4e-06 26.4 0.0 0.011 16.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EAK88236.1 - 1.9e-05 25.2 0.7 0.013 16.0 0.0 3.0 3 0 0 3 3 2 1 ABC transporter Mg_chelatase PF01078.21 EAK88236.1 - 3.2e-05 23.4 0.9 0.027 13.8 0.1 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EAK88236.1 - 4.1e-05 23.6 0.8 0.0036 17.2 0.0 3.4 4 0 0 4 4 4 1 Rad17 P-loop domain NACHT PF05729.12 EAK88236.1 - 6.3e-05 22.9 0.1 0.15 12.0 0.0 3.6 4 0 0 4 4 3 1 NACHT domain Zeta_toxin PF06414.12 EAK88236.1 - 6.5e-05 22.3 0.0 0.025 13.9 0.0 2.7 3 0 0 3 3 3 1 Zeta toxin TsaE PF02367.17 EAK88236.1 - 0.00023 21.2 0.0 0.034 14.2 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EAK88236.1 - 0.00027 20.7 0.0 0.18 11.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 EAK88236.1 - 0.00044 20.2 0.2 0.12 12.3 0.0 3.5 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EAK88236.1 - 0.00053 19.9 1.6 1.7 8.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.6 EAK88236.1 - 0.00074 20.0 2.1 0.16 12.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EAK88236.1 - 0.00084 19.6 0.0 0.11 12.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 EAK88236.1 - 0.0011 18.4 0.4 1.3 8.4 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.11 EAK88236.1 - 0.0015 18.4 0.0 0.71 9.7 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EAK88236.1 - 0.0028 17.4 0.1 0.38 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EAK88236.1 - 0.0037 17.4 0.1 0.57 10.3 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 EAK88236.1 - 0.0046 16.5 0.0 1.2 8.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EAK88236.1 - 0.005 16.0 0.0 0.12 11.4 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DUF815 PF05673.13 EAK88236.1 - 0.0059 15.8 0.0 0.1 11.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 EAK88236.1 - 0.014 15.1 0.1 0.1 12.3 0.0 2.4 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin PF02224.18 EAK88236.1 - 0.017 14.9 0.8 5.8 6.6 0.0 3.0 3 0 0 3 3 3 0 Cytidylate kinase ATPase PF06745.13 EAK88236.1 - 0.017 14.5 4.4 0.6 9.4 0.0 3.7 5 0 0 5 5 4 0 KaiC Cytidylate_kin2 PF13189.6 EAK88236.1 - 0.021 15.0 0.2 3.3 7.8 0.0 2.8 3 0 0 3 3 2 0 Cytidylate kinase-like family SKI PF01202.22 EAK88236.1 - 0.039 14.1 0.5 2.8 8.0 0.0 3.0 3 0 0 3 3 3 0 Shikimate kinase AAA_19 PF13245.6 EAK88236.1 - 0.042 14.2 1.1 13 6.2 0.1 3.0 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 EAK88236.1 - 0.046 12.9 0.1 0.31 10.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 EAK88236.1 - 0.054 13.2 0.2 11 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EAK88236.1 - 0.071 12.3 0.3 8.9 5.4 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IPT PF01745.16 EAK88236.1 - 0.075 12.4 0.2 2.5 7.4 0.0 2.7 3 0 0 3 3 3 0 Isopentenyl transferase KAP_NTPase PF07693.14 EAK88236.1 - 0.12 11.6 0.5 3.7 6.7 0.0 3.2 3 2 1 4 4 4 0 KAP family P-loop domain Cpn60_TCP1 PF00118.24 EAK88237.1 - 1.4e-145 485.7 15.1 1.7e-145 485.5 15.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Isy1 PF06246.12 EAK88238.1 - 5.7e-25 88.3 3.8 6.8e-25 88.1 3.8 1.0 1 0 0 1 1 1 1 Isy1-like splicing family SpoVIF PF14069.6 EAK88238.1 - 0.0014 18.3 1.0 0.0023 17.7 0.1 1.8 2 0 0 2 2 2 1 Stage VI sporulation protein F NFACT-R_1 PF05670.13 EAK88239.1 - 2.7e-32 111.7 0.0 1e-31 109.8 0.0 2.1 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EAK88239.1 - 3.9e-16 58.9 0.0 3.9e-16 58.9 0.0 3.5 3 1 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 EAK88239.1 - 4.3e-14 52.3 2.4 6.2e-14 51.8 0.0 2.6 2 0 0 2 2 2 1 NFACT protein C-terminal domain HORMA PF02301.18 EAK88240.1 - 4.5e-63 212.7 0.3 4.5e-63 212.7 0.3 1.9 2 0 0 2 2 2 1 HORMA domain CVNH PF08881.10 EAK88240.1 - 0.046 14.4 0.1 0.21 12.3 0.0 2.0 2 1 0 2 2 2 0 CVNH domain TrmO PF01980.16 EAK88241.1 - 3.3e-29 101.5 0.1 1.5e-28 99.4 0.0 2.0 2 0 0 2 2 2 1 tRNA-methyltransferase O TrmO_C PF18389.1 EAK88241.1 - 0.00034 20.7 0.0 0.00063 19.8 0.0 1.4 1 0 0 1 1 1 1 TrmO C-terminal domain Aa_trans PF01490.18 EAK88242.1 - 7.8e-36 123.7 44.4 2.5e-35 122.0 44.4 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein zf-CW PF07496.15 EAK88243.1 - 7.2e-16 57.9 5.9 7.2e-16 57.9 5.9 2.0 2 0 0 2 2 2 1 CW-type Zinc Finger IF-2B PF01008.17 EAK88244.1 - 5.1e-34 117.8 0.0 6.1e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF505 PF04458.12 EAK88244.1 - 0.19 10.1 0.1 0.26 9.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) Robl_LC7 PF03259.17 EAK88245.1 - 5.5e-05 22.9 0.0 8.4e-05 22.3 0.0 1.3 1 1 0 1 1 1 1 Roadblock/LC7 domain NDK PF00334.19 EAK88246.1 - 1.5e-50 170.7 0.0 2e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DHHC PF01529.20 EAK88247.1 - 2.5e-29 102.1 14.9 2.5e-29 102.1 14.9 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase RRM_1 PF00076.22 EAK88248.1 - 1.9e-13 50.0 3.7 5.8e-10 38.9 0.5 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lactamase_B_6 PF16661.5 EAK88249.1 - 9.3e-21 74.1 0.0 2.2e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EAK88249.1 - 3.5e-20 72.3 0.0 8.2e-20 71.1 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EAK88249.1 - 3.4e-13 49.3 0.3 8.5e-13 48.0 0.0 1.8 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EAK88249.1 - 3.1e-11 43.6 0.0 1e-07 32.2 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EAK88249.1 - 2.2e-06 27.3 0.0 1.9e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EAK88249.1 - 0.0019 18.1 0.1 0.016 15.1 0.0 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Cry1Ac_D5 PF17997.1 EAK88249.1 - 0.0061 16.4 0.4 0.015 15.2 0.4 1.6 1 0 0 1 1 1 1 Insecticidal delta-endotoxin CryIA(c) domain 5 Acyltransferase PF01553.21 EAK88250.1 - 2.1e-12 46.8 0.0 4.7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Allexi_40kDa PF05549.11 EAK88251.1 - 0.00013 21.6 3.8 0.00071 19.2 0.1 2.3 1 1 0 2 2 2 1 Allexivirus 40kDa protein CENP-Q PF13094.6 EAK88251.1 - 0.11 12.6 7.2 0.22 11.7 6.2 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit BLOC1_2 PF10046.9 EAK88251.1 - 0.15 12.4 15.7 1.8 9.0 8.0 3.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 EAK88251.1 - 0.15 10.9 15.2 0.34 9.8 15.2 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 EAK88251.1 - 0.15 12.6 15.8 2.4 8.7 12.2 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region ApoLp-III PF07464.11 EAK88251.1 - 0.2 11.7 9.4 0.58 10.2 3.7 2.7 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 EAK88251.1 - 0.41 10.7 6.5 2.3 8.2 6.4 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EAK88251.1 - 0.43 10.6 12.0 1 9.4 3.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 EAK88251.1 - 0.54 9.4 15.5 1.3 8.2 0.9 2.4 1 1 1 2 2 2 0 TMPIT-like protein Laminin_II PF06009.12 EAK88251.1 - 0.68 9.9 9.7 1.4 8.9 1.5 2.4 2 0 0 2 2 2 0 Laminin Domain II YabA PF06156.13 EAK88251.1 - 0.92 10.2 13.3 3.9 8.2 5.2 3.0 1 1 1 2 2 2 0 Initiation control protein YabA Syntaxin-6_N PF09177.11 EAK88251.1 - 1.2 9.8 9.8 0.33 11.5 1.3 2.7 1 1 0 2 2 2 0 Syntaxin 6, N-terminal HMMR_N PF15905.5 EAK88251.1 - 1.2 8.5 20.0 3.2 7.1 20.0 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal HAP1_N PF04849.13 EAK88251.1 - 1.8 7.7 15.0 1.1 8.4 1.3 2.3 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF3450 PF11932.8 EAK88251.1 - 2.1 7.6 8.5 4.6 6.5 6.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EAK88251.1 - 2.3 8.5 16.5 0.97 9.7 11.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.9 EAK88251.1 - 3 7.9 18.6 1.9 8.5 1.1 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.6 EAK88251.1 - 5.2 7.5 19.9 9.7 6.6 0.1 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Fzo_mitofusin PF04799.13 EAK88251.1 - 7.9 6.0 9.8 12 5.4 0.1 2.6 1 1 1 2 2 2 0 fzo-like conserved region Ribosomal_L13 PF00572.18 EAK88252.1 - 2e-07 31.3 0.1 4.8e-05 23.6 0.0 2.7 2 1 0 2 2 2 1 Ribosomal protein L13 ParA PF10609.9 EAK88253.1 - 4.7e-68 229.3 0.0 2.1e-67 227.2 0.0 1.9 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 EAK88253.1 - 5.9e-15 55.6 0.4 1.8e-14 54.0 0.4 1.8 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EAK88253.1 - 1.7e-11 44.3 0.0 3.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF971 PF06155.12 EAK88253.1 - 4.7e-11 43.2 0.0 1.3e-10 41.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF971) FeS_assembly_P PF01883.19 EAK88253.1 - 1.9e-09 37.5 0.0 6.6e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein ArsA_ATPase PF02374.15 EAK88253.1 - 3.9e-06 26.3 3.4 0.0058 15.9 1.0 3.1 2 1 1 3 3 3 2 Anion-transporting ATPase MipZ PF09140.11 EAK88253.1 - 4.3e-06 26.2 0.1 1.1e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 ATPase MipZ Fer4_NifH PF00142.18 EAK88253.1 - 0.0013 18.3 0.0 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 EAK88253.1 - 0.02 14.4 0.0 0.057 12.9 0.0 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 EAK88253.1 - 0.075 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop TrmO PF01980.16 EAK88254.1 - 8.8e-36 122.7 0.0 1.8e-35 121.7 0.0 1.5 1 0 0 1 1 1 1 tRNA-methyltransferase O Arg_tRNA_synt_N PF03485.16 EAK88254.1 - 0.0093 16.5 0.3 0.69 10.5 0.0 2.6 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain Pkinase PF00069.25 EAK88255.1 - 1.2e-82 277.3 0.6 2.2e-82 276.4 0.6 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88255.1 - 1.5e-43 148.9 0.4 2.9e-43 148.0 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EAK88255.1 - 1e-27 93.6 12.0 1.8e-06 27.1 0.1 4.8 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAK88255.1 - 5.1e-27 94.1 20.3 1e-09 38.7 0.6 3.6 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EAK88255.1 - 3.2e-22 76.5 7.6 6.5e-06 25.7 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EAK88255.1 - 8.5e-20 70.4 11.9 7.2e-05 22.6 0.1 4.9 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 EAK88255.1 - 3.4e-19 67.4 10.6 4.4e-06 26.0 0.2 4.6 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 EAK88255.1 - 7.3e-08 32.7 1.7 0.0015 18.8 0.2 3.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Kinase-like PF14531.6 EAK88255.1 - 4.1e-07 29.6 0.1 5.4e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 Kinase-like EF-hand_4 PF12763.7 EAK88255.1 - 2e-06 27.7 5.7 0.0021 18.0 0.7 3.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Pkinase_fungal PF17667.1 EAK88255.1 - 1.1e-05 24.4 0.1 2.2e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EAK88255.1 - 0.0014 18.1 0.1 0.0028 17.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAK88255.1 - 0.0088 16.0 0.0 0.027 14.4 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family PP2C PF00481.21 EAK88256.1 - 3.2e-32 112.2 0.0 3.9e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C OGFr_N PF04664.13 EAK88256.1 - 0.033 13.7 0.1 4 6.9 0.1 2.1 2 0 0 2 2 2 0 Opioid growth factor receptor (OGFr) conserved region rpo132 PF12415.8 EAK88256.1 - 0.055 12.8 0.1 0.26 10.6 0.0 2.0 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase Malic_M PF03949.15 EAK88257.1 - 3.5e-85 285.4 0.1 4.8e-85 284.9 0.1 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EAK88257.1 - 6.3e-56 189.0 0.0 1.1e-55 188.2 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain GHL10 PF02638.15 EAK88257.1 - 0.12 11.4 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 YIF1 PF03878.15 EAK88258.1 - 5.6e-35 121.0 11.7 7.5e-35 120.6 11.7 1.2 1 0 0 1 1 1 1 YIF1 RRM_1 PF00076.22 EAK88259.1 - 1.9e-36 123.7 0.0 3.3e-20 71.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK88259.1 - 5e-10 39.4 0.0 0.00035 20.6 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EAK88259.1 - 3.5e-05 23.7 0.1 0.088 12.8 0.0 2.7 2 1 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Laminin_G_1 PF00054.23 EAK88259.1 - 0.059 13.6 0.4 4.4 7.5 0.1 2.5 2 0 0 2 2 2 0 Laminin G domain PHM7_cyt PF14703.6 EAK88259.1 - 0.079 13.2 0.0 15 5.7 0.0 2.6 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CSD PF00313.22 EAK88259.1 - 0.22 11.4 0.3 13 5.7 0.0 2.5 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain IMCp PF12314.8 EAK88260.1 - 3.3e-24 85.0 104.7 6.4e-13 48.8 35.3 5.9 1 1 4 5 5 5 5 Inner membrane complex protein SelP_N PF04592.14 EAK88261.1 - 8.7 5.7 16.1 19 4.6 16.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ala_racemase_N PF01168.20 EAK88262.1 - 5e-14 52.5 0.0 6.2e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Sigma_1s PF02454.16 EAK88262.1 - 0.046 13.7 0.6 5.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Sigma 1s protein DUF1667 PF07892.11 EAK88262.1 - 0.11 12.6 0.2 6.2 7.0 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1667) ATP-synt_D PF01813.17 EAK88263.1 - 6.9e-62 208.8 1.3 9.5e-62 208.3 1.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit D Alpha_E2_glycop PF00943.19 EAK88263.1 - 0.14 10.9 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Alphavirus E2 glycoprotein YtxH PF12732.7 EAK88263.1 - 9.2 6.9 7.3 4.3 7.9 0.2 2.6 2 1 0 2 2 2 0 YtxH-like protein GDPD PF03009.17 EAK88264.1 - 1.8e-26 93.4 0.0 2.5e-18 66.7 0.0 2.3 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family zf-C3HC4_3 PF13920.6 EAK88265.1 - 5e-08 32.7 6.9 5e-07 29.5 3.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK88265.1 - 8.6e-08 32.0 6.7 6.6e-07 29.2 2.8 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EAK88265.1 - 1.1e-07 31.6 6.7 3.6e-07 29.9 6.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK88265.1 - 1.1e-06 28.5 6.7 2.7e-06 27.3 6.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EAK88265.1 - 1.9e-06 27.6 3.8 1.9e-06 27.6 3.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK88265.1 - 2.5e-06 27.7 10.8 2.9e-05 24.3 10.8 2.4 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EAK88265.1 - 8.8e-05 22.7 7.2 0.00034 20.8 7.2 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EAK88265.1 - 0.00016 21.4 5.3 0.004 17.0 2.7 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EAK88265.1 - 0.00042 20.4 6.9 0.0038 17.4 2.6 2.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EAK88265.1 - 0.00082 19.1 6.3 0.0028 17.4 3.2 2.4 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain DUF1272 PF06906.11 EAK88265.1 - 0.011 15.8 1.0 0.011 15.8 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-ANAPC11 PF12861.7 EAK88265.1 - 0.06 13.4 4.3 0.17 12.0 4.4 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger GxGYxYP_C PF14323.6 EAK88265.1 - 0.079 12.8 4.6 0.03 14.2 1.0 1.9 1 1 2 3 3 3 0 GxGYxYP putative glycoside hydrolase C-terminal domain zf-RING_10 PF16685.5 EAK88265.1 - 0.13 12.4 7.5 0.085 13.0 4.9 2.0 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EAK88265.1 - 0.23 11.4 3.2 0.17 11.7 1.6 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein PAP1 PF08601.10 EAK88265.1 - 0.27 10.9 26.5 0.38 10.4 26.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 zf-MIZ PF02891.20 EAK88265.1 - 0.5 10.2 5.0 8.1 6.3 2.6 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Peptidase_S64 PF08192.11 EAK88265.1 - 1.6 7.2 27.6 2 6.8 27.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 zf-P11 PF03854.14 EAK88265.1 - 2.4 7.9 6.6 0.36 10.5 2.0 2.0 2 0 0 2 2 2 0 P-11 zinc finger Cnd1 PF12717.7 EAK88265.1 - 3.5 7.7 13.0 2.3 8.3 6.8 2.4 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 CAP_C PF08603.11 EAK88266.1 - 2.9e-46 157.0 7.3 4.2e-46 156.4 7.3 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EAK88266.1 - 5.4e-06 26.1 4.5 9.8e-06 25.3 4.5 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C YabA PF06156.13 EAK88267.1 - 0.031 14.9 3.4 0.031 14.9 3.4 5.1 1 1 3 4 4 4 0 Initiation control protein YabA DUF2205 PF10224.9 EAK88267.1 - 0.39 10.7 10.9 0.061 13.3 4.8 3.0 3 1 0 3 3 3 0 Short coiled-coil protein RAP80_UIM PF18282.1 EAK88267.1 - 6.1 6.7 6.5 2.2 8.1 0.4 2.7 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif Arm PF00514.23 EAK88268.1 - 0.11 12.5 1.1 38 4.5 0.0 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat G-patch PF01585.23 EAK88270.1 - 2.9e-14 52.7 3.0 6.4e-14 51.6 3.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EAK88270.1 - 5.8e-09 35.9 0.1 5.8e-09 35.9 0.1 2.6 2 1 0 2 2 2 1 G-patch domain Dsh_C PF12316.8 EAK88270.1 - 8.9 6.7 10.7 11 6.4 10.7 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Myb_Cef PF11831.8 EAK88271.1 - 8.6e-19 68.1 4.9 8.6e-19 68.1 4.9 2.4 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EAK88271.1 - 2.3e-18 66.1 10.2 8.6e-12 45.1 0.7 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EAK88271.1 - 3.6e-16 59.2 3.4 1.5e-11 44.4 2.3 3.3 2 1 1 3 3 3 2 Myb-like DNA-binding domain Poxvirus_B22R_N PF13169.6 EAK88274.1 - 0.85 10.2 3.6 4.4 7.8 0.2 2.3 2 0 0 2 2 2 0 Poxvirus B22R protein N-terminal F-box PF00646.33 EAK88275.1 - 0.045 13.6 0.1 0.13 12.2 0.1 1.9 1 0 0 1 1 1 0 F-box domain VP7 PF00434.18 EAK88279.1 - 0.0083 15.3 0.2 0.0083 15.3 0.2 1.0 1 0 0 1 1 1 1 Glycoprotein VP7 CSF-1 PF05337.11 EAK88279.1 - 0.047 13.8 1.7 0.057 13.5 1.7 1.3 1 1 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) O-antigen_lig PF13425.6 EAK88279.1 - 0.11 11.3 2.4 0.11 11.3 2.4 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Transformer PF06495.11 EAK88280.1 - 0.0015 18.7 24.7 0.0015 18.7 24.7 3.3 2 1 1 3 3 3 1 Fruit fly transformer protein Colicin_immun PF09204.10 EAK88281.1 - 0.051 14.1 2.5 0.17 12.4 2.5 2.0 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity Sigma_reg_N PF13800.6 EAK88284.1 - 4.3 7.7 6.8 13 6.2 6.8 1.9 1 1 0 1 1 1 0 Sigma factor regulator N-terminal Abhydrolase_2 PF02230.16 EAK88286.1 - 2.5e-29 102.6 0.0 3e-28 99.1 0.0 1.9 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EAK88286.1 - 0.0048 16.2 0.0 0.14 11.4 0.0 2.6 2 1 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EAK88286.1 - 0.12 13.0 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ank_2 PF12796.7 EAK88287.1 - 1.1e-20 74.0 0.1 7.3e-10 39.3 0.0 5.5 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EAK88287.1 - 4.5e-12 46.0 4.1 0.03 14.6 0.0 6.7 6 1 2 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAK88287.1 - 4.8e-12 44.9 0.5 1.3 9.8 0.0 7.5 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 EAK88287.1 - 2.4e-10 40.7 0.4 0.035 14.7 0.0 6.2 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EAK88287.1 - 2.4e-08 34.0 0.3 0.14 12.6 0.1 5.4 4 0 0 4 4 4 2 Ankyrin repeat SET PF00856.28 EAK88287.1 - 0.077 13.4 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 SET domain SIS PF01380.22 EAK88288.1 - 3.5e-46 156.3 1.7 1.8e-24 86.1 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EAK88288.1 - 2e-22 79.8 0.0 4.6e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EAK88288.1 - 1.9e-17 63.3 0.0 3.6e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain bact-PGI_C PF10432.9 EAK88288.1 - 0.00018 21.6 0.0 0.0006 19.9 0.0 1.9 1 1 0 1 1 1 1 Bacterial phospho-glucose isomerase C-terminal SIS domain GATase_4 PF13230.6 EAK88288.1 - 0.01 14.8 0.0 0.021 13.7 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferases class-II SIS_2 PF13580.6 EAK88288.1 - 0.086 12.9 3.7 12 5.9 0.1 3.6 2 2 1 3 3 3 0 SIS domain AMP-binding PF00501.28 EAK88289.1 - 4.7e-91 305.5 0.0 6.3e-91 305.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EAK88289.1 - 2.1e-21 76.7 0.1 8.4e-21 74.7 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EAK88289.1 - 3.6e-18 65.2 0.1 8e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus WD40 PF00400.32 EAK88290.1 - 5.6e-25 87.1 19.0 9.6e-05 23.1 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88290.1 - 1e-16 61.0 10.5 1.1e-07 32.0 1.2 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EAK88290.1 - 6.2e-08 32.7 1.8 0.12 12.2 0.0 3.4 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EAK88290.1 - 7.6e-05 21.8 0.2 0.056 12.4 0.0 3.0 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EAK88290.1 - 0.00022 20.0 2.3 0.1 11.2 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EAK88290.1 - 1 8.2 7.6 0.067 12.1 1.0 2.2 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain SNF2_N PF00176.23 EAK88291.1 - 1.7e-61 207.9 0.2 1.5e-60 204.8 0.1 2.0 1 1 1 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.24 EAK88291.1 - 1.6e-23 82.3 2.5 1.6e-10 40.7 0.5 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EAK88291.1 - 2.9e-20 72.7 0.0 1.1e-19 70.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EAK88291.1 - 1.4e-10 40.8 4.2 2.1e-10 40.3 0.9 3.0 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EAK88291.1 - 2.9e-07 30.6 0.0 2.9e-07 30.6 0.0 3.9 3 2 1 4 4 4 1 Type III restriction enzyme, res subunit DUF4208 PF13907.6 EAK88291.1 - 2.3e-06 27.9 0.1 2.5e-05 24.6 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) DEAD PF00270.29 EAK88291.1 - 0.0014 18.5 0.0 0.058 13.2 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Big_3_4 PF13754.6 EAK88292.1 - 0.11 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DotA PF11388.8 EAK88292.1 - 0.12 12.6 0.4 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Phagosome trafficking protein DotA Patatin PF01734.22 EAK88293.1 - 3.8e-10 40.3 1.0 6.4e-09 36.3 1.0 2.5 1 1 0 1 1 1 1 Patatin-like phospholipase PITH PF06201.13 EAK88295.1 - 7.5e-32 110.6 0.0 9.6e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 PITH domain UBA2_C PF16195.5 EAK88296.1 - 0.41 11.4 4.8 6.6 7.5 0.2 2.5 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus DLIC PF05783.11 EAK88297.1 - 9.5e-05 21.4 16.4 0.0095 14.8 0.0 4.4 3 2 1 4 4 4 3 Dynein light intermediate chain (DLIC) TAFII55_N PF04658.13 EAK88298.1 - 1.2e-13 51.2 0.0 3.8e-13 49.5 0.0 1.9 2 1 0 2 2 2 1 TAFII55 protein conserved region DUF1676 PF07898.13 EAK88299.1 - 0.12 12.4 0.1 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Reticulon PF02453.17 EAK88299.1 - 0.19 11.7 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Reticulon ABC2_membrane_3 PF12698.7 EAK88300.1 - 0.062 12.4 1.7 0.082 12.0 1.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Vfa1 PF08432.10 EAK88300.1 - 0.079 13.3 3.0 0.1 12.9 3.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 EAK88300.1 - 1 8.0 3.1 1.1 7.9 3.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4615 PF15393.6 EAK88301.1 - 0.035 14.7 2.6 0.086 13.4 2.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) Mucin PF01456.17 EAK88303.1 - 6e-05 23.1 45.8 0.00013 22.0 45.8 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein BAT2_N PF07001.11 EAK88303.1 - 0.037 14.5 6.5 0.075 13.5 6.5 1.5 1 0 0 1 1 1 0 BAT2 N-terminus PAN_4 PF14295.6 EAK88303.1 - 0.073 13.0 0.8 0.21 11.5 0.8 1.7 1 0 0 1 1 1 0 PAN domain SWI-SNF_Ssr4 PF08549.10 EAK88303.1 - 0.53 8.9 8.7 0.75 8.4 8.7 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) AJAP1_PANP_C PF15298.6 EAK88303.1 - 0.71 10.1 25.8 1.4 9.1 25.8 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Med13_C PF06333.12 EAK88303.1 - 3.2 6.9 13.8 5.4 6.2 13.8 1.3 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain AP2 PF00847.20 EAK88304.1 - 1.3e-11 44.5 3.7 2.4e-11 43.7 3.7 1.4 1 0 0 1 1 1 1 AP2 domain RRM_1 PF00076.22 EAK88305.1 - 3e-37 126.3 0.0 3e-17 62.2 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EAK88305.1 - 0.0067 16.5 0.1 1.9 8.6 0.0 2.6 2 1 0 2 2 2 2 Limkain b1 RRM_3 PF08777.11 EAK88305.1 - 0.026 14.6 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 EAK88305.1 - 0.035 14.2 0.0 13 5.9 0.0 2.7 2 1 1 3 3 3 0 RNA recognition motif DUF4944 PF16302.5 EAK88305.1 - 0.04 14.0 0.5 18 5.4 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4944) RRM_Rrp7 PF17799.1 EAK88305.1 - 0.16 11.8 0.0 0.77 9.5 0.0 2.0 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain TPR_19 PF14559.6 EAK88306.1 - 6.8e-09 36.1 0.6 0.00071 20.0 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EAK88306.1 - 1e-07 31.5 11.6 0.73 9.8 0.5 8.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EAK88306.1 - 5.2e-06 26.6 5.1 21 5.5 0.0 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 EAK88306.1 - 2.5e-05 24.1 22.4 3.1 8.1 0.1 9.0 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.6 EAK88306.1 - 9.6e-05 22.3 8.7 3 8.3 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EAK88306.1 - 0.00018 22.1 0.0 0.65 10.7 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EAK88306.1 - 0.00019 21.3 0.2 15 5.9 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK88306.1 - 0.00046 20.3 9.3 0.21 11.9 0.0 5.0 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EAK88306.1 - 0.00057 20.5 0.0 18 6.5 0.0 5.8 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EAK88306.1 - 1.8 9.4 5.6 69 4.4 0.0 5.6 8 0 0 8 8 8 0 Tetratricopeptide repeat PCI PF01399.27 EAK88307.1 - 8e-10 39.2 0.3 4.5e-09 36.8 0.3 2.2 2 1 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 EAK88307.1 - 1.8e-05 24.3 0.3 4.2e-05 23.1 0.3 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix TSP_1 PF00090.19 EAK88309.1 - 3.3e-08 33.6 14.3 3.6e-06 27.1 4.3 6.3 7 1 0 7 7 7 4 Thrombospondin type 1 domain PAN_1 PF00024.26 EAK88309.1 - 2.6e-06 27.3 11.4 0.0002 21.3 3.2 3.9 4 1 1 5 5 5 2 PAN domain PAN_4 PF14295.6 EAK88309.1 - 0.0066 16.3 1.7 0.0066 16.3 1.7 4.0 3 0 0 3 3 3 1 PAN domain TSP_1 PF00090.19 EAK88310.1 - 3.2e-20 72.1 103.3 3.7e-09 36.7 5.7 8.5 9 1 0 9 9 9 6 Thrombospondin type 1 domain PAN_4 PF14295.6 EAK88310.1 - 0.0011 18.8 1.5 0.0011 18.8 1.5 6.6 7 0 0 7 7 7 1 PAN domain SKG6 PF08693.10 EAK88310.1 - 0.24 10.8 0.7 0.55 9.7 0.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Glyco_hydro_7 PF00840.20 EAK88311.1 - 0.033 12.9 1.6 0.042 12.6 1.6 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 7 Baculo_PEP_C PF04513.12 EAK88311.1 - 0.055 13.5 2.0 0.13 12.3 1.3 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Perilipin PF03036.16 EAK88311.1 - 0.12 11.4 9.6 0.13 11.3 9.6 1.1 1 0 0 1 1 1 0 Perilipin family TerY_C PF15616.6 EAK88311.1 - 0.18 11.9 3.3 0.2 11.7 2.3 1.6 1 1 0 1 1 1 0 TerY-C metal binding domain ISG65-75 PF11727.8 EAK88311.1 - 0.71 9.1 11.8 1.1 8.4 11.5 1.4 1 1 0 1 1 1 0 Invariant surface glycoprotein Exonuc_VII_L PF02601.15 EAK88311.1 - 1.3 8.5 14.3 1.5 8.3 14.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Myb_DNA-bind_3 PF12776.7 EAK88311.1 - 1.4 10.0 10.2 0.19 12.7 4.0 2.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Allexi_40kDa PF05549.11 EAK88311.1 - 1.5 8.3 6.8 1.6 8.1 5.9 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF3574 PF12098.8 EAK88311.1 - 1.8 8.4 6.3 1.3 8.9 2.2 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF3574) DUF1664 PF07889.12 EAK88311.1 - 2 8.4 10.9 0.55 10.3 3.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RP-C_C PF11800.8 EAK88311.1 - 2.1 8.4 11.1 1.8 8.6 9.7 1.5 1 1 1 2 2 2 0 Replication protein C C-terminal region Atg14 PF10186.9 EAK88311.1 - 5.6 5.9 21.9 6.7 5.7 21.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Goodbye PF17109.5 EAK88311.1 - 5.9 7.4 10.0 8.7 6.8 3.2 2.4 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain ERCC4 PF02732.15 EAK88313.1 - 2.7e-21 76.4 0.0 2.7e-21 76.4 0.0 3.2 1 1 3 4 4 4 1 ERCC4 domain HHH_8 PF14716.6 EAK88313.1 - 0.00017 21.9 0.0 0.0043 17.4 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix domain Ca_hom_mod PF14798.6 EAK88313.1 - 0.11 11.6 0.0 1.2 8.2 0.0 2.1 2 0 0 2 2 2 0 Calcium homeostasis modulator CS PF04969.16 EAK88315.1 - 0.016 16.2 2.8 0.057 14.4 2.8 1.9 1 1 0 1 1 1 0 CS domain Apis_Csd PF11671.8 EAK88315.1 - 0.019 15.0 5.7 0.031 14.3 5.7 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein DUF1842 PF08896.10 EAK88315.1 - 0.035 14.4 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1842) GPI2 PF06432.11 EAK88316.1 - 1.3e-48 165.9 21.2 3.7e-48 164.4 21.2 1.6 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Peptidase_M41 PF01434.18 EAK88317.1 - 2.1e-55 187.5 0.0 4.8e-55 186.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EAK88317.1 - 9.6e-42 142.5 0.0 2.2e-41 141.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAK88317.1 - 6.1e-10 38.7 0.0 1.8e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EAK88317.1 - 9e-06 25.7 0.0 2.6e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EAK88317.1 - 0.00069 18.9 0.0 0.0019 17.4 0.0 1.8 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EAK88317.1 - 0.0014 18.9 0.1 0.034 14.4 0.1 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EAK88317.1 - 0.0015 18.3 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EAK88317.1 - 0.0037 17.3 0.3 0.022 14.8 0.0 2.6 3 0 0 3 3 3 1 AAA domain FtsH_ext PF06480.15 EAK88317.1 - 0.0037 17.6 1.0 0.0037 17.6 1.0 3.7 3 1 0 3 3 3 1 FtsH Extracellular AAA_16 PF13191.6 EAK88317.1 - 0.0047 17.3 0.1 0.029 14.8 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EAK88317.1 - 0.013 15.6 0.0 0.037 14.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EAK88317.1 - 0.019 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EAK88317.1 - 0.023 14.8 0.0 0.066 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EAK88317.1 - 0.032 13.6 0.1 0.068 12.5 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 EAK88317.1 - 0.063 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EAK88317.1 - 0.23 12.0 1.3 0.66 10.5 0.1 2.5 3 1 0 3 3 2 0 AAA domain Myb_DNA-bind_6 PF13921.6 EAK88318.1 - 0.0012 19.0 0.0 0.0028 17.9 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-C3HC4_2 PF13923.6 EAK88319.1 - 1.2e-09 37.9 8.0 2e-09 37.1 8.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK88319.1 - 4.9e-09 35.9 9.4 8.7e-09 35.1 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK88319.1 - 1.4e-05 25.3 8.0 2.4e-05 24.6 8.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EAK88319.1 - 1.8e-05 24.5 5.2 3.1e-05 23.8 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK88319.1 - 5.5e-05 23.1 9.0 0.00011 22.1 9.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EAK88319.1 - 7.7e-05 22.8 7.9 0.00015 21.8 7.9 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EAK88319.1 - 8.2e-05 22.6 8.6 0.00017 21.6 8.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 EAK88319.1 - 0.0027 17.5 5.9 0.0052 16.6 3.5 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit RAWUL PF16207.5 EAK88319.1 - 0.014 16.1 0.0 0.079 13.6 0.0 2.2 1 1 1 2 2 2 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_6 PF14835.6 EAK88319.1 - 0.034 14.0 4.1 0.06 13.2 4.1 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-TFIIB PF13453.6 EAK88319.1 - 0.078 12.3 0.6 1.1 8.6 0.0 2.4 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc-ribbons_6 PF07191.12 EAK88319.1 - 0.1 12.6 2.5 0.19 11.7 2.5 1.4 1 0 0 1 1 1 0 zinc-ribbons zf-RING_4 PF14570.6 EAK88319.1 - 0.38 10.6 6.2 0.14 12.0 2.9 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EAK88319.1 - 0.45 10.4 10.3 20 5.2 11.3 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF1272 PF06906.11 EAK88319.1 - 5.8 7.1 7.7 38 4.5 8.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) zf-C3HC4_5 PF17121.5 EAK88319.1 - 6.6 6.7 8.6 46 4.0 8.6 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EAK88319.1 - 7.4 6.9 9.5 27 5.1 9.5 1.9 1 1 1 2 2 2 0 RING-H2 zinc finger domain Cyclin_N PF00134.23 EAK88320.1 - 6e-07 29.3 0.5 1.1e-06 28.4 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain MAT1 PF06391.13 EAK88321.1 - 1.2e-09 38.3 15.7 3.6e-09 36.8 15.7 1.8 1 1 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-RING_2 PF13639.6 EAK88321.1 - 7.8e-07 29.3 7.1 9.2e-07 29.1 5.8 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 EAK88321.1 - 4.8e-05 23.1 13.0 0.00079 19.3 12.1 3.2 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK88321.1 - 0.00021 21.2 8.0 0.00021 21.2 8.0 2.5 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EAK88321.1 - 0.00035 20.4 6.5 0.0015 18.3 6.5 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 EAK88321.1 - 0.00036 20.3 8.8 0.0019 18.0 5.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK88321.1 - 0.00044 20.0 10.5 0.02 14.7 10.5 3.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EAK88321.1 - 0.00064 19.8 3.1 0.0015 18.6 3.1 1.7 1 0 0 1 1 1 1 FYVE zinc finger zf-RING_UBOX PF13445.6 EAK88321.1 - 0.00079 19.4 1.7 0.00079 19.4 1.7 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 EAK88321.1 - 0.0018 18.0 5.6 0.0056 16.5 5.6 1.9 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EAK88321.1 - 0.0027 17.5 11.3 0.46 10.4 8.6 2.8 2 1 0 2 2 2 2 Prokaryotic RING finger family 4 DZR PF12773.7 EAK88321.1 - 0.33 11.0 6.5 1.6 8.8 6.5 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_4 PF15227.6 EAK88321.1 - 0.35 11.0 13.1 1.2 9.4 5.8 3.5 3 1 1 4 4 4 0 zinc finger of C3HC4-type, RING Prim_Zn_Ribbon PF08273.12 EAK88321.1 - 0.36 11.1 6.2 0.45 10.8 1.9 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Ribosomal_L37ae PF01780.19 EAK88321.1 - 1.6 8.9 4.7 3.4 7.8 1.4 2.6 2 1 0 2 2 2 0 Ribosomal L37ae protein family Wx5_PLAF3D7 PF09688.10 EAK88321.1 - 2.3 8.2 9.5 1.5 8.8 7.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) zf-rbx1 PF12678.7 EAK88321.1 - 6.8 7.1 9.5 83 3.6 9.4 2.7 1 1 1 2 2 2 0 RING-H2 zinc finger domain Adaptin_binding PF10199.9 EAK88322.1 - 0.00075 20.1 7.5 0.0013 19.3 0.4 3.2 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 Flu_B_M2 PF04772.12 EAK88322.1 - 0.17 12.1 1.8 1.3 9.3 0.4 2.7 3 0 0 3 3 3 0 Influenza B matrix protein 2 (BM2) EF-hand_6 PF13405.6 EAK88326.1 - 6e-08 32.0 2.0 0.0043 16.9 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EAK88326.1 - 3.1e-07 30.7 0.6 0.0005 20.5 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAK88326.1 - 1.6e-06 27.3 8.4 0.0036 16.7 0.1 3.6 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EAK88326.1 - 0.0008 19.2 0.3 0.65 9.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EAK88326.1 - 0.0053 16.2 1.9 0.13 11.8 0.0 3.2 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.9 EAK88326.1 - 0.11 12.8 0.2 5.7 7.3 0.1 2.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region GBP PF02263.19 EAK88327.1 - 0.0018 17.6 2.8 0.25 10.6 0.2 3.3 2 1 0 2 2 2 2 Guanylate-binding protein, N-terminal domain Vma12 PF11712.8 EAK88328.1 - 1.1e-08 35.2 0.0 1.1e-08 35.2 0.0 2.3 1 1 1 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2856 PF11043.8 EAK88328.1 - 0.0028 17.7 0.0 0.055 13.6 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2856) V_ATPase_I PF01496.19 EAK88328.1 - 0.22 9.4 8.0 0.19 9.6 0.0 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family CDT1_C PF16679.5 EAK88330.1 - 0.27 11.7 3.1 0.41 11.1 1.7 2.1 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain PH PF00169.29 EAK88331.1 - 5.4e-10 39.7 13.6 0.0012 19.3 0.2 5.5 4 0 0 4 4 4 3 PH domain TES PF08034.11 EAK88331.1 - 0.042 14.1 1.0 0.18 12.1 1.0 2.1 1 0 0 1 1 1 0 Trematode eggshell synthesis protein Suf PF05843.14 EAK88332.1 - 0.00018 21.6 27.0 0.00071 19.7 1.7 5.5 5 1 0 5 5 5 4 Suppressor of forked protein (Suf) Cyclin_N PF00134.23 EAK88333.1 - 7.8e-12 45.0 0.2 1.6e-11 44.0 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Sas10 PF09368.10 EAK88334.1 - 3.5e-21 75.5 11.0 3.5e-21 75.5 11.0 3.3 4 0 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EAK88334.1 - 2.4e-14 53.7 1.7 2.4e-14 53.7 1.7 4.3 4 1 0 4 4 4 1 Sas10/Utp3/C1D family Condensation PF00668.20 EAK88335.1 - 3.4e-09 35.9 0.0 7.5e-09 34.8 0.0 1.5 2 0 0 2 2 2 1 Condensation domain GCP_C_terminal PF04130.13 EAK88336.1 - 4.5e-08 32.9 8.6 4.5e-08 32.9 8.6 1.9 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal PAN_3 PF08277.12 EAK88336.1 - 0.0065 16.3 0.3 0.02 14.7 0.3 1.9 1 0 0 1 1 1 1 PAN-like domain Phage_RpbA PF10789.9 EAK88336.1 - 0.045 13.8 0.2 1.1 9.4 0.0 2.7 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA EOS1 PF12326.8 EAK88339.1 - 0.063 13.2 3.8 0.038 13.9 0.4 2.4 2 0 0 2 2 2 0 N-glycosylation protein Connexin PF00029.19 EAK88339.1 - 1.2 8.8 7.9 3.3 7.4 2.5 2.8 2 0 0 2 2 2 0 Connexin CPSF100_C PF13299.6 EAK88339.1 - 2.5 8.3 7.3 10 6.3 7.3 2.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Polysacc_deac_1 PF01522.21 EAK88340.1 - 3.1e-12 46.5 0.0 2.2e-10 40.5 0.0 2.2 2 0 0 2 2 2 2 Polysaccharide deacetylase Cation_efflux PF01545.21 EAK88341.1 - 4.6e-43 147.3 22.4 1.2e-42 145.9 22.4 1.6 1 1 0 1 1 1 1 Cation efflux family TIM PF00121.18 EAK88342.1 - 5.3e-88 294.5 0.0 6e-88 294.3 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Zn_ribbon_17 PF17120.5 EAK88343.1 - 4.2e-06 26.3 11.7 1.6e-05 24.4 11.7 2.1 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 EAK88343.1 - 1.9 9.5 8.6 20 6.3 0.0 5.1 5 0 0 5 5 5 0 WD domain, G-beta repeat ER_lumen_recept PF00810.18 EAK88344.1 - 6.6e-37 127.6 5.5 6.6e-37 127.6 5.5 2.1 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EAK88344.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.7 3 1 0 3 3 3 0 PQ loop repeat CGI-121 PF08617.10 EAK88345.1 - 2.5e-06 27.7 1.0 4.3e-06 27.0 0.8 1.5 1 1 1 2 2 2 1 Kinase binding protein CGI-121 DnaJ PF00226.31 EAK88346.1 - 8.2e-10 38.7 2.4 1.5e-09 37.8 2.4 1.5 1 0 0 1 1 1 1 DnaJ domain V-SNARE_C PF12352.8 EAK88348.1 - 1.1e-10 41.6 2.6 1.1e-10 41.6 2.6 2.9 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EAK88348.1 - 0.00068 19.5 0.3 0.00068 19.5 0.3 2.6 2 1 0 2 2 2 1 Sec20 BRE1 PF08647.11 EAK88348.1 - 0.0023 18.0 11.2 0.0041 17.2 3.8 2.4 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase ASD1 PF08688.10 EAK88348.1 - 0.0074 16.7 0.5 0.016 15.6 0.3 1.7 1 1 1 2 2 2 1 Apx/Shroom domain ASD1 Allexi_40kDa PF05549.11 EAK88348.1 - 0.016 14.7 1.1 0.022 14.3 1.1 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein HTH_19 PF12844.7 EAK88348.1 - 0.043 13.8 0.2 0.44 10.6 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain TFIIS_M PF07500.14 EAK88348.1 - 0.06 13.8 1.9 0.11 13.0 1.9 1.6 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain SCP-1 PF05483.12 EAK88348.1 - 0.14 10.1 9.0 0.052 11.6 5.5 1.7 1 1 1 2 2 2 0 Synaptonemal complex protein 1 (SCP-1) Syntaxin-18_N PF10496.9 EAK88348.1 - 0.42 10.9 5.0 1.3 9.3 2.7 2.6 1 1 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus KxDL PF10241.9 EAK88348.1 - 0.45 10.8 6.7 12 6.3 2.1 3.1 2 1 0 2 2 2 0 Uncharacterized conserved protein V-SNARE PF05008.15 EAK88348.1 - 2 8.9 10.1 2.3 8.6 0.9 3.6 3 1 1 4 4 4 0 Vesicle transport v-SNARE protein N-terminus Fzo_mitofusin PF04799.13 EAK88348.1 - 3.3 7.2 6.8 6.8 6.2 2.0 2.4 2 0 0 2 2 2 0 fzo-like conserved region Utp21 PF04192.12 EAK88349.1 - 2e-42 145.3 5.0 3.3e-42 144.6 5.0 1.4 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EAK88349.1 - 5.5e-11 42.6 0.7 0.0018 18.6 0.0 4.9 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EAK88349.1 - 2.6e-08 34.4 5.5 0.055 14.4 0.0 6.2 6 0 0 6 6 6 2 WD domain, G-beta repeat Hira PF07569.11 EAK88349.1 - 0.00055 19.7 0.2 0.00055 19.7 0.2 3.0 5 0 0 5 5 5 1 TUP1-like enhancer of split YccV-like PF08755.11 EAK88351.1 - 1.1e-18 67.5 0.2 4e-18 65.7 0.2 2.0 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like PRKCSH PF07915.13 EAK88351.1 - 3.5e-07 31.1 0.0 3.5e-07 31.1 0.0 3.2 3 1 1 4 4 4 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 EAK88351.1 - 0.002 17.8 0.1 0.0078 15.9 0.0 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein RRM_1 PF00076.22 EAK88352.1 - 4.4e-49 164.2 0.0 1.5e-21 76.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK88352.1 - 3.1e-05 24.0 0.0 0.08 13.1 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EAK88352.1 - 0.002 18.1 0.0 0.0097 15.9 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EAK88352.1 - 0.052 13.1 0.0 0.5 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med7 PF05983.11 EAK88353.1 - 9.9e-23 81.2 11.6 4.6e-21 75.8 11.6 2.0 1 1 0 1 1 1 1 MED7 protein KASH_CCD PF14662.6 EAK88353.1 - 0.0019 18.1 6.8 0.0023 17.8 6.8 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH BCDHK_Adom3 PF10436.9 EAK88353.1 - 0.0026 17.6 1.1 0.0036 17.2 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF641 PF04859.12 EAK88353.1 - 0.0089 16.4 1.7 0.011 16.0 1.7 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) SKA2 PF16740.5 EAK88353.1 - 0.011 15.5 2.9 0.016 15.0 2.9 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 HBM PF16591.5 EAK88353.1 - 0.021 14.3 0.4 0.026 13.9 0.4 1.1 1 0 0 1 1 1 0 Helical bimodular sensor domain EST1_DNA_bind PF10373.9 EAK88353.1 - 0.028 13.9 0.2 0.03 13.8 0.2 1.1 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain DUF1825 PF08855.10 EAK88353.1 - 0.031 14.2 1.6 0.06 13.3 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) Sec2p PF06428.11 EAK88353.1 - 0.05 13.6 3.2 0.081 12.9 3.2 1.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Med2 PF11214.8 EAK88353.1 - 0.065 13.4 3.6 0.13 12.4 3.6 1.6 1 1 0 1 1 1 0 Mediator complex subunit 2 FOXP-CC PF16159.5 EAK88353.1 - 0.074 13.7 1.0 0.15 12.7 1.0 1.5 1 0 0 1 1 1 0 FOXP coiled-coil domain PCRF PF03462.18 EAK88353.1 - 0.088 12.7 1.5 0.11 12.4 1.5 1.1 1 0 0 1 1 1 0 PCRF domain DUF948 PF06103.11 EAK88353.1 - 0.11 12.8 0.9 0.19 12.0 0.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 EAK88353.1 - 0.2 11.3 0.7 0.25 11.1 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) RNA_pol_Rpb2_6 PF00562.28 EAK88354.1 - 8e-120 400.5 0.0 1.1e-119 400.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EAK88354.1 - 3.9e-34 117.9 0.0 8.5e-34 116.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EAK88354.1 - 2.2e-26 91.8 0.0 4.4e-26 90.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EAK88354.1 - 2.1e-19 69.7 0.0 4.7e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 EAK88354.1 - 6e-10 39.0 0.0 1.5e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EAK88354.1 - 0.16 11.6 0.0 1.7 8.2 0.0 2.3 1 1 0 1 1 1 0 RNA polymerase Rpb2, domain 2 AAA PF00004.29 EAK88355.1 - 2e-10 41.2 0.4 1.3e-09 38.6 0.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EAK88355.1 - 0.003 17.9 1.7 0.11 12.8 0.1 3.5 3 2 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EAK88355.1 - 0.0033 16.6 0.0 0.047 12.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 EAK88355.1 - 0.019 14.7 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EAK88355.1 - 0.025 14.5 0.0 0.09 12.7 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 EAK88355.1 - 0.032 14.4 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EAK88355.1 - 0.038 14.1 0.0 0.13 12.3 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EAK88355.1 - 0.061 13.0 0.1 0.33 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EAK88355.1 - 0.063 13.7 0.0 0.68 10.4 0.0 2.7 2 0 0 2 2 2 0 RNA helicase DUF2554 PF10829.8 EAK88355.1 - 0.068 13.6 0.0 0.25 11.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2554) ATP_bind_1 PF03029.17 EAK88355.1 - 0.1 12.3 0.5 0.56 9.9 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF1493 PF07377.12 EAK88355.1 - 0.11 13.0 3.3 1.1 9.8 0.1 3.8 3 1 1 4 4 3 0 Protein of unknown function (DUF1493) AAA_22 PF13401.6 EAK88355.1 - 0.16 12.2 1.5 2.8 8.2 0.1 3.2 2 1 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EAK88355.1 - 0.18 12.3 0.1 0.18 12.3 0.1 2.5 3 1 0 3 3 3 0 ABC transporter Zw10 PF06248.13 EAK88356.1 - 7e-26 90.9 3.4 7e-26 90.9 3.4 1.6 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Peptidase_M24 PF00557.24 EAK88357.1 - 9.7e-52 175.7 0.0 1.7e-51 174.9 0.0 1.4 2 0 0 2 2 2 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EAK88357.1 - 9.1e-15 54.7 10.5 9.1e-15 54.7 10.5 2.0 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EAK88357.1 - 3.8e-05 23.7 6.5 0.0001 22.3 6.5 1.8 1 0 0 1 1 1 1 MYND finger PolC_DP2 PF03833.13 EAK88357.1 - 0.75 7.6 4.9 0.85 7.4 1.1 2.0 2 0 0 2 2 2 0 DNA polymerase II large subunit DP2 zinc-ribbons_6 PF07191.12 EAK88357.1 - 1 9.4 7.7 0.39 10.7 3.7 2.2 2 0 0 2 2 2 0 zinc-ribbons RNA_pol_A_bac PF01000.26 EAK88359.1 - 1.7e-26 92.8 0.0 3.1e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EAK88359.1 - 7.2e-21 73.4 0.0 1e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Na_Ca_ex PF01699.24 EAK88360.1 - 2.7e-38 131.3 41.4 4.4e-22 78.7 17.8 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF2627 PF11118.8 EAK88360.1 - 0.08 13.5 2.3 0.6 10.7 0.1 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) TFIID_NTD2 PF04494.15 EAK88361.1 - 1.3e-18 67.4 2.0 1.3e-18 67.4 2.0 2.3 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 EAK88361.1 - 1.7e-15 57.1 20.3 4.3e-06 27.4 0.5 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88361.1 - 4.5e-06 26.9 1.8 1.6 9.1 0.1 5.3 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF818 PF05677.12 EAK88362.1 - 1.7e-06 27.3 1.5 2.7e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 Chlamydia CHLPS protein (DUF818) Hydrolase_4 PF12146.8 EAK88362.1 - 9.8e-05 21.7 0.0 0.069 12.4 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK88362.1 - 0.018 14.7 0.0 1.1 8.8 0.1 2.5 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF4831 PF16115.5 EAK88362.1 - 0.036 13.1 1.5 0.077 12.0 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4831) Arf PF00025.21 EAK88363.1 - 3e-16 59.4 0.0 1.7e-13 50.4 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family SRPRB PF09439.10 EAK88363.1 - 5.7e-05 22.6 0.5 0.0054 16.2 0.5 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EAK88363.1 - 0.0047 16.1 0.1 0.0066 15.6 0.1 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Ras PF00071.22 EAK88363.1 - 0.0047 16.5 0.0 2.9 7.4 0.0 2.2 2 0 0 2 2 2 2 Ras family T2SSE PF00437.20 EAK88363.1 - 0.025 13.6 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein zinc_ribbon_6 PF14599.6 EAK88364.1 - 3.6e-19 68.5 1.7 3.6e-19 68.5 1.7 4.4 2 1 3 5 5 5 1 Zinc-ribbon zf-CHY PF05495.12 EAK88364.1 - 6.9e-16 58.5 25.9 6.9e-16 58.5 25.9 3.9 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EAK88364.1 - 7.9e-07 29.3 2.5 7.9e-07 29.3 2.5 6.0 2 1 2 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 EAK88364.1 - 1.9e-06 27.8 1.1 1.9e-06 27.8 1.1 5.8 7 1 1 8 8 8 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAK88364.1 - 0.00024 21.0 4.0 0.00024 21.0 4.0 6.5 2 1 2 5 5 5 1 zinc-RING finger domain zf-RING_11 PF17123.5 EAK88364.1 - 0.011 15.5 2.7 0.011 15.5 2.7 5.5 5 0 0 5 5 5 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 EAK88364.1 - 0.019 15.1 2.3 0.019 15.1 2.3 6.4 4 3 2 6 6 6 0 zinc finger of C3HC4-type, RING Porin_3 PF01459.22 EAK88365.1 - 2.9e-26 92.5 0.3 3.7e-26 92.2 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic porin PAS_12 PF18095.1 EAK88365.1 - 0.07 12.8 0.2 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain Ctr PF04145.15 EAK88366.1 - 2e-18 67.4 20.0 5.2e-10 40.1 1.4 2.1 1 1 1 2 2 2 2 Ctr copper transporter family H_PPase PF03030.16 EAK88366.1 - 0.0022 16.7 2.5 0.0025 16.5 2.5 1.1 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase Spidroin_N PF16763.5 EAK88366.1 - 0.025 14.6 0.1 0.038 14.0 0.1 1.2 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term Bac_GDH PF05088.12 EAK88366.1 - 0.23 8.9 0.1 0.25 8.8 0.1 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase HXXEE PF13787.6 EAK88366.1 - 2.6 8.9 8.3 5.8 7.8 8.3 1.5 1 1 0 1 1 1 0 Protein of unknown function with HXXEE motif Filamin PF00630.19 EAK88367.1 - 5.3e-19 68.9 6.7 3.9e-13 50.1 0.1 3.5 4 0 0 4 4 4 2 Filamin/ABP280 repeat TMEM71 PF15121.6 EAK88367.1 - 0.0077 15.9 0.1 0.027 14.1 0.1 1.9 1 0 0 1 1 1 1 TMEM71 protein family Lectin_N PF03954.14 EAK88368.1 - 2 8.1 4.9 29 4.4 4.0 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain SRP68 PF16969.5 EAK88371.1 - 3.7e-35 122.0 11.7 2.3e-27 96.2 5.0 3.0 2 1 0 2 2 2 2 RNA-binding signal recognition particle 68 Sld3_N PF18523.1 EAK88371.1 - 0.028 14.5 0.7 0.098 12.8 0.1 2.3 2 0 0 2 2 2 0 Sld3 N-terminal domain VirB8 PF04335.13 EAK88372.1 - 0.055 13.3 0.1 0.081 12.7 0.1 1.3 1 0 0 1 1 1 0 VirB8 protein Radical_SAM_C PF16199.5 EAK88373.1 - 1.6e-20 72.9 0.0 4.4e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EAK88373.1 - 8.8e-11 42.5 4.1 4.4e-10 40.2 3.0 2.7 2 1 0 2 2 2 1 Radical SAM superfamily Terpene_synth_C PF03936.16 EAK88373.1 - 0.033 13.5 0.1 0.07 12.5 0.1 1.5 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Acetyltransf_1 PF00583.25 EAK88373.1 - 0.048 13.9 0.4 0.14 12.4 0.4 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family O-FucT PF10250.9 EAK88374.1 - 8.7e-52 176.9 1.5 1.1e-51 176.5 1.5 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Actin PF00022.19 EAK88375.1 - 1.1e-19 70.4 0.0 4.6e-17 61.7 0.0 2.5 1 1 0 2 2 2 2 Actin Myb_DNA-binding PF00249.31 EAK88378.1 - 0.00071 19.7 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribonuc_P_40 PF08584.11 EAK88379.1 - 0.0066 15.8 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit Clathrin_propel PF01394.20 EAK88379.1 - 0.15 12.4 3.0 3.2 8.2 0.4 3.1 2 0 0 2 2 2 0 Clathrin propeller repeat Rad1 PF02144.16 EAK88380.1 - 1.2e-06 27.8 2.8 8.4e-06 25.0 2.8 1.9 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EAK88380.1 - 0.0041 16.6 1.3 0.0044 16.5 1.3 1.1 1 0 0 1 1 1 1 Rad9 Cyclin_N PF00134.23 EAK88381.1 - 2.4e-14 53.2 0.1 4.1e-10 39.5 0.0 2.6 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EAK88381.1 - 3.7e-12 46.4 0.1 8.5e-12 45.2 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain FliM PF02154.15 EAK88381.1 - 0.0066 16.4 0.2 3.2 7.6 0.0 2.5 2 1 0 2 2 2 2 Flagellar motor switch protein FliM Ribosomal_S26e PF01283.19 EAK88382.1 - 1.4e-48 163.8 11.4 1.5e-48 163.7 11.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e SRP19 PF01922.17 EAK88382.1 - 0.033 15.1 0.1 0.05 14.5 0.1 1.3 1 0 0 1 1 1 0 SRP19 protein RNA_pol_Rpb8 PF03870.15 EAK88383.1 - 1.9e-40 138.3 0.0 2.1e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EAK88383.1 - 6.5e-05 23.0 0.0 0.0014 18.7 0.0 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G DEK_C PF08766.11 EAK88384.1 - 6.9e-11 41.9 1.8 8.5e-11 41.6 0.2 1.9 2 0 0 2 2 2 1 DEK C terminal domain Lge1 PF11488.8 EAK88384.1 - 0.9 9.8 8.4 2 8.7 0.8 3.3 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 FlaF PF07309.11 EAK88385.1 - 0.049 13.6 0.1 0.087 12.8 0.1 1.4 1 0 0 1 1 1 0 Flagellar protein FlaF CTK3 PF12243.8 EAK88385.1 - 0.056 13.4 0.1 0.092 12.7 0.1 1.3 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 YabA PF06156.13 EAK88385.1 - 0.16 12.6 1.4 0.21 12.2 1.4 1.3 1 1 0 1 1 1 0 Initiation control protein YabA Na_H_Exchanger PF00999.21 EAK88387.1 - 3.4e-49 167.7 56.5 5e-49 167.1 56.5 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TIG PF01833.24 EAK88387.1 - 1.5e-06 28.1 6.0 0.0079 16.2 0.7 3.9 2 1 0 2 2 2 2 IPT/TIG domain PgaD PF13994.6 EAK88387.1 - 0.088 12.9 5.4 1.4 8.9 0.5 2.9 2 0 0 2 2 2 0 PgaD-like protein DUF4144 PF13642.6 EAK88387.1 - 0.18 12.4 0.4 4 8.1 0.0 2.7 2 0 0 2 2 2 0 protein structure with unknown function AAA PF00004.29 EAK88388.1 - 2.5e-35 121.8 1.3 1.5e-34 119.3 0.1 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EAK88388.1 - 5.1e-07 29.6 0.0 1.1e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EAK88388.1 - 8.6e-05 22.7 0.1 0.00074 19.7 0.0 2.3 1 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAK88388.1 - 0.00014 21.9 0.0 0.0005 20.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EAK88388.1 - 0.00018 21.8 1.9 0.13 12.6 0.0 4.0 2 1 1 4 4 4 1 AAA domain AAA_16 PF13191.6 EAK88388.1 - 0.0044 17.4 0.0 0.13 12.6 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EAK88388.1 - 0.0091 16.5 2.6 0.12 12.9 0.8 3.0 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EAK88388.1 - 0.0099 16.3 0.0 0.034 14.6 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 EAK88388.1 - 0.022 14.9 0.0 0.063 13.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EAK88388.1 - 0.022 14.5 0.0 0.059 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EAK88388.1 - 0.037 13.3 0.0 0.068 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EAK88388.1 - 0.093 12.4 0.1 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EAK88388.1 - 0.13 12.2 1.8 11 5.9 0.0 2.7 2 1 1 3 3 3 0 NACHT domain AAA_30 PF13604.6 EAK88388.1 - 0.22 11.2 0.0 0.4 10.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain SET PF00856.28 EAK88389.1 - 3.5e-11 43.8 3.7 4.4e-11 43.5 3.0 1.9 1 1 0 1 1 1 1 SET domain GYF PF02213.16 EAK88390.1 - 4.7e-05 23.0 0.1 0.00017 21.2 0.0 2.0 2 0 0 2 2 2 1 GYF domain BTB PF00651.31 EAK88390.1 - 0.0046 17.2 0.1 0.021 15.1 0.1 2.2 1 1 0 1 1 1 1 BTB/POZ domain GYF PF02213.16 EAK88391.1 - 4.1e-08 32.7 0.0 8.1e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 GYF domain BTB PF00651.31 EAK88391.1 - 0.00025 21.2 0.1 0.0019 18.4 0.1 2.5 1 1 0 1 1 1 1 BTB/POZ domain tRNA-synt_1c PF00749.21 EAK88392.1 - 1.2e-100 336.5 0.1 2.3e-100 335.5 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EAK88392.1 - 1.4e-35 122.7 0.6 2.8e-35 121.7 0.6 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain PI31_Prot_N PF11566.8 EAK88393.1 - 0.0043 16.9 0.0 0.0066 16.3 0.0 1.3 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal HEAT PF02985.22 EAK88394.1 - 3.3e-10 39.3 4.6 1.5 9.2 0.0 8.4 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EAK88394.1 - 0.00012 22.4 0.0 0.26 11.7 0.0 4.2 4 0 0 4 4 4 1 HEAT repeats Poxvirus_B22R_C PF13168.6 EAK88394.1 - 0.02 14.4 0.0 0.1 12.0 0.0 2.3 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal Regnase_1_C PF18561.1 EAK88395.1 - 0.18 11.6 0.2 0.4 10.5 0.2 1.5 1 0 0 1 1 1 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain Cytochrom_c3_2 PF14537.6 EAK88395.1 - 1.3 9.6 5.6 9.2 6.8 2.3 2.4 2 0 0 2 2 2 0 Cytochrome c3 DZR PF12773.7 EAK88395.1 - 4.1 7.5 9.4 18 5.4 1.4 2.9 2 1 0 2 2 2 0 Double zinc ribbon Pkinase PF00069.25 EAK88396.1 - 0.00024 20.5 13.9 0.00059 19.3 3.3 3.3 4 0 0 4 4 4 2 Protein kinase domain WD40 PF00400.32 EAK88396.1 - 0.034 15.0 0.1 0.16 12.9 0.1 2.2 1 0 0 1 1 1 0 WD domain, G-beta repeat SVM_signal PF12113.8 EAK88396.1 - 0.46 10.4 10.9 5.3 7.0 6.0 4.2 2 0 0 2 2 2 0 SVM protein signal sequence PWWP PF00855.17 EAK88397.1 - 0.012 16.0 0.0 0.56 10.6 0.0 2.6 1 1 1 2 2 2 0 PWWP domain Methyltransf_22 PF13383.6 EAK88397.1 - 0.047 13.2 0.7 0.5 9.9 0.1 2.2 2 0 0 2 2 2 0 Methyltransferase domain Mog1 PF04603.12 EAK88398.1 - 2.1e-30 105.9 0.0 2.7e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein DUF202 PF02656.15 EAK88399.1 - 2.1 8.9 9.1 0.3 11.6 1.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF202) DUF4501 PF14946.6 EAK88399.1 - 8.7 6.4 7.1 1.9 8.5 3.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4501) TauE PF01925.19 EAK88400.1 - 4.1e-22 79.0 16.9 1e-11 45.0 5.2 2.6 2 2 0 2 2 2 2 Sulfite exporter TauE/SafE STAG PF08514.11 EAK88400.1 - 0.049 13.5 0.2 2.2 8.2 0.0 2.6 2 1 0 2 2 2 0 STAG domain DUF1356 PF07092.12 EAK88400.1 - 0.18 11.1 6.5 0.53 9.5 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1356) DUF2628 PF10947.8 EAK88400.1 - 7.3 7.0 8.0 6.5 7.2 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2628) Prp19 PF08606.11 EAK88402.1 - 0.02 14.9 0.2 0.13 12.3 0.5 2.2 2 0 0 2 2 2 0 Prp19/Pso4-like COPI_assoc PF08507.10 EAK88403.1 - 1.6e-06 28.2 6.2 2e-06 27.9 6.2 1.1 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.9 EAK88403.1 - 0.23 11.8 5.4 0.36 11.2 5.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein CG6151-P Prenyltrans PF00432.21 EAK88404.1 - 3.8e-32 109.7 13.8 2.5e-10 39.9 3.3 5.3 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat DUF2093 PF09866.9 EAK88404.1 - 0.7 9.4 5.4 0.58 9.6 2.3 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2093) Utp14 PF04615.13 EAK88405.1 - 1.2e-56 192.7 40.4 7.5e-32 110.8 36.3 2.2 1 1 1 2 2 2 2 Utp14 protein TORC_N PF12884.7 EAK88405.1 - 0.1 13.4 2.1 1.2 9.9 1.3 3.2 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus Sec20 PF03908.13 EAK88405.1 - 0.25 11.3 8.0 7.5 6.6 1.4 3.6 2 1 0 2 2 2 0 Sec20 HECT PF00632.25 EAK88406.1 - 6.6e-63 213.0 0.8 6.6e-63 213.0 0.8 3.6 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 EAK88406.1 - 1.5e-08 34.8 1.0 5.4e-08 33.0 1.0 1.9 1 0 0 1 1 1 1 SPRY domain UBA PF00627.31 EAK88406.1 - 0.00022 21.1 0.1 0.00059 19.7 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Laminin_G_3 PF13385.6 EAK88406.1 - 0.0087 16.2 0.5 0.083 13.0 0.3 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DnaJ PF00226.31 EAK88407.1 - 1.6e-11 44.1 0.0 4e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain UPRTase PF14681.6 EAK88408.1 - 7.7e-59 198.6 0.0 9.3e-59 198.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EAK88408.1 - 0.0025 17.3 0.0 0.0056 16.2 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain ACT_5 PF13710.6 EAK88409.1 - 0.056 13.3 2.1 0.073 12.9 0.7 1.9 2 0 0 2 2 2 0 ACT domain ZnuA PF01297.17 EAK88409.1 - 0.067 12.6 0.1 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic IF-2B PF01008.17 EAK88410.1 - 2.8e-18 66.1 6.9 4e-17 62.3 6.9 2.5 1 1 0 1 1 1 1 Initiation factor 2 subunit family DUF4298 PF14131.6 EAK88410.1 - 0.065 13.2 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) GSH-S_ATP PF02955.16 EAK88411.1 - 0.081 12.3 1.6 0.69 9.3 0.0 2.7 2 1 1 3 3 3 0 Prokaryotic glutathione synthetase, ATP-grasp domain G-patch PF01585.23 EAK88412.1 - 6.5e-16 57.9 1.4 1.2e-15 57.2 1.4 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EAK88412.1 - 7.3e-05 22.8 1.1 0.00014 21.8 1.1 1.6 1 1 0 1 1 1 1 G-patch domain TB2_DP1_HVA22 PF03134.19 EAK88414.1 - 4.4e-29 100.2 12.0 4.5e-29 100.2 8.0 2.1 2 0 0 2 2 2 1 TB2/DP1, HVA22 family YvrJ PF12841.7 EAK88414.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 YvrJ protein family CAF1A PF12253.8 EAK88415.1 - 1.6e-08 34.6 3.0 4.6e-08 33.1 3.0 1.8 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A zf-RING_2 PF13639.6 EAK88417.1 - 1.3e-07 31.8 13.1 2.7e-07 30.8 13.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EAK88417.1 - 5.5e-06 26.6 11.9 1.2e-05 25.5 11.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EAK88417.1 - 0.00031 20.7 11.2 0.00055 19.8 11.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EAK88417.1 - 0.00036 20.1 12.0 0.00077 19.0 12.0 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EAK88417.1 - 0.00058 19.7 11.2 0.0015 18.4 11.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_9 PF13901.6 EAK88417.1 - 0.00065 19.7 10.5 0.0012 18.9 10.5 1.3 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon zf-C3HC4_2 PF13923.6 EAK88417.1 - 0.00084 19.1 15.5 0.0029 17.4 15.5 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EAK88417.1 - 0.0038 17.3 5.4 0.0096 16.0 5.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EAK88417.1 - 0.0056 16.5 11.6 0.016 15.1 11.6 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EAK88417.1 - 0.012 15.4 11.1 0.022 14.6 11.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EAK88417.1 - 0.045 13.8 8.4 0.1 12.7 8.4 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 EAK88417.1 - 0.42 10.4 15.6 0.072 12.8 10.5 2.5 2 1 0 2 2 2 0 RING-like zinc finger FANCL_C PF11793.8 EAK88417.1 - 1.6 9.0 10.3 5.6 7.2 10.3 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 EAK88417.1 - 5.2 7.0 11.3 9.5 6.2 11.3 1.5 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 EAK88417.1 - 5.4 7.2 11.3 11 6.3 11.3 1.5 1 0 0 1 1 1 0 RING-variant domain STAG PF08514.11 EAK88418.1 - 0.05 13.5 4.7 7.1 6.6 2.0 2.9 2 1 0 2 2 2 0 STAG domain KIAA1430 PF13879.6 EAK88418.1 - 0.13 13.0 8.1 9.3 7.1 0.2 3.3 2 1 1 3 3 3 0 KIAA1430 homologue CDC50 PF03381.15 EAK88419.1 - 4.9e-29 101.7 4.3 4.9e-29 101.7 4.3 1.9 1 1 1 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family US10 PF17617.2 EAK88420.1 - 0.066 13.3 2.6 0.31 11.1 0.6 2.4 2 0 0 2 2 2 0 Viral unique short region 10 DDRGK PF09756.9 EAK88421.1 - 2.8e-32 111.8 20.5 3.6e-32 111.5 20.5 1.1 1 0 0 1 1 1 1 DDRGK domain LPD25 PF18840.1 EAK88421.1 - 0.087 13.4 4.6 0.15 12.6 4.2 1.8 1 1 0 1 1 1 0 Large polyvalent protein associated domain 25 Hydrolase_3 PF08282.12 EAK88422.1 - 5.6e-30 104.9 0.0 1.3e-28 100.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EAK88422.1 - 1.7e-06 27.7 0.0 3.9e-05 23.3 0.0 2.4 2 1 1 3 3 3 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EAK88422.1 - 0.027 14.7 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EAK88422.1 - 0.051 13.7 0.0 0.13 12.3 0.0 1.8 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase SpoU_methylase PF00588.19 EAK88423.1 - 7.8e-25 87.7 0.0 1.5e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF4709 PF15821.5 EAK88423.1 - 0.034 14.4 0.7 0.14 12.4 0.7 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4709) DUF2009 PF09418.10 EAK88424.1 - 5.2e-182 606.0 3.9 1.2e-120 403.7 0.0 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF2009) S_layer_N PF05123.12 EAK88424.1 - 0.058 13.2 0.3 0.058 13.2 0.3 1.7 2 0 0 2 2 2 0 S-layer like family, N-terminal region His_Phos_1 PF00300.22 EAK88425.1 - 7.1e-19 68.3 0.0 1.5e-11 44.4 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF4364 PF14277.6 EAK88425.1 - 0.0093 15.7 0.3 0.018 14.8 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) His_Phos_2 PF00328.22 EAK88425.1 - 0.045 13.1 0.1 0.057 12.8 0.1 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) GATA PF00320.27 EAK88426.1 - 6.9e-07 28.8 4.7 3.1e-06 26.7 4.7 2.2 1 0 0 1 1 1 1 GATA zinc finger PHD PF00628.29 EAK88427.1 - 0.00065 19.5 10.2 0.002 18.0 10.2 1.9 1 0 0 1 1 1 1 PHD-finger C1_2 PF03107.16 EAK88427.1 - 0.016 15.5 2.0 0.016 15.5 2.0 3.2 3 0 0 3 3 3 0 C1 domain PWWP PF00855.17 EAK88427.1 - 0.11 12.9 1.1 0.32 11.4 0.0 2.5 2 0 0 2 2 2 0 PWWP domain Prok-RING_1 PF14446.6 EAK88427.1 - 0.21 11.6 7.5 0.69 9.9 7.5 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 HypA PF01155.19 EAK88427.1 - 0.32 11.0 4.4 2.9 7.9 1.2 2.7 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EAK88427.1 - 0.65 10.1 11.3 3 7.9 6.6 3.2 2 1 1 3 3 3 0 Double zinc ribbon ADK_lid PF05191.14 EAK88427.1 - 2.7 8.0 12.2 0.045 13.7 3.6 2.6 3 0 0 3 3 3 0 Adenylate kinase, active site lid Ribosomal_L36e PF01158.18 EAK88428.1 - 3.2e-37 126.7 2.6 3.5e-37 126.5 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Bystin PF05291.11 EAK88429.1 - 2.2e-103 345.6 5.3 3.4e-103 345.0 5.3 1.2 1 0 0 1 1 1 1 Bystin TFIIF_beta PF02270.15 EAK88429.1 - 0.13 12.5 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain DUF681 PF05080.12 EAK88430.1 - 0.039 14.6 0.0 0.058 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF681) PLU-1 PF08429.11 EAK88431.1 - 2.9e-19 69.4 68.2 6.5e-19 68.3 14.0 9.2 7 2 0 8 8 8 5 PLU-1-like protein PHD PF00628.29 EAK88431.1 - 3.2e-07 30.1 7.8 1e-06 28.5 7.8 2.0 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EAK88431.1 - 0.0083 16.2 10.2 0.031 14.4 10.2 2.1 1 0 0 1 1 1 1 PHD-finger Rhodanese_C PF12368.8 EAK88431.1 - 0.2 12.1 5.2 0.7 10.3 5.2 1.9 1 0 0 1 1 1 0 Rhodanase C-terminal Zf_RING PF16744.5 EAK88431.1 - 0.22 11.7 6.1 1.3 9.2 6.1 2.4 1 1 0 1 1 1 0 KIAA1045 RING finger SHS2_Rpb7-N PF03876.17 EAK88434.1 - 2.8e-07 30.8 0.0 6.7e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RPA43_OB PF17875.1 EAK88434.1 - 0.0018 18.9 0.0 0.0033 18.1 0.0 1.5 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I E2F_TDP PF02319.20 EAK88437.1 - 3.5e-14 52.6 0.0 7.4e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EAK88437.1 - 0.031 14.2 0.1 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB PCI PF01399.27 EAK88438.1 - 6.3e-10 39.5 2.8 6.3e-10 39.5 2.8 3.2 3 1 0 3 3 3 1 PCI domain Med9 PF07544.13 EAK88438.1 - 0.0012 18.9 1.7 2.3 8.4 0.0 4.1 3 1 0 3 3 3 2 RNA polymerase II transcription mediator complex subunit 9 CSN8_PSD8_EIF3K PF10075.9 EAK88438.1 - 0.015 15.3 0.7 0.1 12.6 0.1 2.6 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family WD40 PF00400.32 EAK88439.1 - 1.2e-09 38.6 9.4 0.0035 18.2 0.6 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88439.1 - 0.015 15.6 0.0 0.46 10.8 0.0 3.1 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Ephrin_rec_like PF07699.13 EAK88440.1 - 4.9e-10 39.0 24.8 3.4e-08 33.1 8.5 3.8 2 1 1 3 3 3 2 Putative ephrin-receptor like TNFR_c6 PF00020.18 EAK88440.1 - 1.7 9.1 9.7 5.7 7.4 0.7 3.4 1 1 0 2 2 2 0 TNFR/NGFR cysteine-rich region DUF2341 PF10102.9 EAK88441.1 - 0.067 13.8 0.1 0.12 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2341) E1-E2_ATPase PF00122.20 EAK88441.1 - 0.24 10.9 3.9 0.089 12.3 1.1 1.5 2 0 0 2 2 2 0 E1-E2 ATPase ThrE PF06738.12 EAK88441.1 - 1.4 8.2 6.5 2 7.7 6.4 1.3 1 1 0 1 1 1 0 Putative threonine/serine exporter APG6_N PF17675.1 EAK88442.1 - 0.39 11.3 10.4 0.68 10.5 2.2 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region ATP-synt_D PF01813.17 EAK88442.1 - 0.79 9.5 11.8 2.4 7.9 3.1 2.5 3 0 0 3 3 3 0 ATP synthase subunit D CENP-H PF05837.12 EAK88442.1 - 1.8 9.0 11.5 0.29 11.5 0.9 2.6 3 0 0 3 3 3 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 EAK88442.1 - 2.2 8.4 7.2 59 3.7 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2968 PF11180.8 EAK88442.1 - 6.5 6.4 14.7 0.072 12.7 3.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) HTH_37 PF13744.6 EAK88445.1 - 0.072 13.1 0.1 0.25 11.3 0.1 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain zf-CRD PF17979.1 EAK88445.1 - 0.86 9.7 3.4 3.8 7.6 0.2 2.9 3 0 0 3 3 3 0 Cysteine rich domain with multizinc binding regions FliS PF02561.14 EAK88446.1 - 0.018 15.3 5.5 0.31 11.3 0.1 4.1 3 1 0 3 3 3 0 Flagellar protein FliS LZ3wCH PF18517.1 EAK88446.1 - 0.033 14.3 1.4 14 5.9 0.1 4.1 4 0 0 4 4 4 0 Leucine zipper with capping helix domain C8 PF08742.11 EAK88446.1 - 0.12 12.8 0.1 0.27 11.7 0.1 1.6 1 0 0 1 1 1 0 C8 domain Ribosomal_S13 PF00416.22 EAK88446.1 - 3.1 8.2 11.3 10 6.5 0.1 4.9 2 2 2 5 5 5 0 Ribosomal protein S13/S18 PRANC PF09372.10 EAK88447.1 - 5.4 7.4 10.0 0.93 9.9 0.1 3.1 3 1 0 3 3 3 0 PRANC domain HisKA PF00512.25 EAK88448.1 - 0.12 12.4 0.8 0.2 11.7 0.3 1.6 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain IZUMO PF15005.6 EAK88450.1 - 0.21 12.1 0.1 0.21 12.1 0.1 3.1 4 0 0 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated Plk4_PB1 PF18190.1 EAK88451.1 - 0.012 15.8 0.9 0.026 14.7 0.3 2.0 2 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 DHHC PF01529.20 EAK88452.1 - 3.9e-35 120.9 27.3 4.8e-35 120.6 12.3 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF2975 PF11188.8 EAK88452.1 - 6.8 6.6 11.0 9.3 6.2 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) DUF2439 PF10382.9 EAK88453.1 - 1.6e-12 47.6 0.7 3e-12 46.7 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) ABC_membrane PF00664.23 EAK88454.1 - 5e-31 108.4 17.6 7.3e-31 107.8 17.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EAK88454.1 - 2.7e-30 105.7 0.1 9.6e-30 103.9 0.0 2.0 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EAK88454.1 - 3.9e-05 23.2 0.0 0.00013 21.5 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 EAK88454.1 - 0.029 14.1 0.6 0.59 9.8 0.0 2.8 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EAK88454.1 - 0.039 13.1 0.0 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 EAK88454.1 - 0.17 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Glyco_transf_41 PF13844.6 EAK88456.1 - 1.8e-40 138.8 0.5 8.3e-23 80.6 0.0 3.3 3 1 0 3 3 3 2 Glycosyl transferase family 41 TPR_1 PF00515.28 EAK88456.1 - 3.6e-19 67.7 3.5 2.9e-05 23.7 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EAK88456.1 - 1.8e-17 62.0 0.1 2.5e-05 24.1 0.0 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EAK88456.1 - 4.5e-17 60.8 5.5 0.0001 22.2 0.0 6.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EAK88456.1 - 1.4e-14 53.3 4.3 0.00063 19.9 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EAK88456.1 - 1.8e-09 37.0 0.0 0.15 12.2 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EAK88456.1 - 2.2e-09 37.5 0.0 0.016 15.4 0.0 4.6 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EAK88456.1 - 2.2e-08 33.6 1.0 0.0049 16.5 0.0 4.9 2 1 3 5 5 5 2 TPR repeat TPR_10 PF13374.6 EAK88456.1 - 1.8e-07 30.8 0.1 1.9 8.5 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EAK88456.1 - 3.1e-06 27.6 0.0 1.8 9.2 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EAK88456.1 - 0.0058 17.3 0.0 2e+02 3.2 0.0 5.0 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EAK88456.1 - 0.0069 16.9 0.0 9 7.2 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat CtsR_C PF17727.1 EAK88456.1 - 0.11 12.7 2.7 1.1 9.4 0.3 2.9 2 0 0 2 2 2 0 CtsR C-terminal dimerization domain Phage_holin_3_1 PF05106.12 EAK88456.1 - 0.14 12.6 0.0 2.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) KH_1 PF00013.29 EAK88458.1 - 1.6e-25 88.7 4.2 6e-07 29.2 0.0 5.0 5 0 0 5 5 5 4 KH domain KH_4 PF13083.6 EAK88458.1 - 1e-05 25.3 0.3 0.042 13.7 0.0 4.3 4 1 0 4 4 4 1 KH domain KH_2 PF07650.17 EAK88458.1 - 2.7e-05 23.9 1.1 2.2 8.1 0.0 4.2 3 1 1 4 4 4 2 KH domain DUF2969 PF11184.8 EAK88458.1 - 0.0034 17.8 0.4 1.9 8.9 0.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2969) CHZ PF09649.10 EAK88458.1 - 0.2 11.2 0.1 0.2 11.2 0.1 1.9 2 0 0 2 2 2 0 Histone chaperone domain CHZ Presenilin PF01080.17 EAK88459.1 - 0.036 12.8 12.1 0.047 12.5 12.1 1.3 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 EAK88459.1 - 0.057 12.2 9.8 0.068 11.9 9.8 1.1 1 0 0 1 1 1 0 Raftlin SpoIIIAH PF12685.7 EAK88459.1 - 0.22 11.3 17.1 0.31 10.8 17.1 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Ndc1_Nup PF09531.10 EAK88459.1 - 0.23 10.1 8.3 0.25 10.0 8.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOBP PF15279.6 EAK88459.1 - 0.4 11.3 12.5 0.49 11.0 12.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein CDC45 PF02724.14 EAK88459.1 - 0.55 8.5 19.1 0.71 8.1 19.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Smg8_Smg9 PF10220.9 EAK88459.1 - 0.72 8.1 15.2 0.95 7.7 15.2 1.1 1 0 0 1 1 1 0 Smg8_Smg9 SLC12 PF03522.15 EAK88459.1 - 2 7.3 15.8 2.5 7.0 15.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF5427 PF10310.9 EAK88459.1 - 2.7 6.9 22.1 3.9 6.3 22.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Neur_chan_memb PF02932.16 EAK88459.1 - 3.1 7.8 10.3 5.4 7.0 10.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.16 EAK88459.1 - 3.4 7.1 18.3 5.4 6.5 18.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4662 PF15578.6 EAK88459.1 - 4.7 6.9 18.1 11 5.8 18.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4662) Hid1 PF12722.7 EAK88459.1 - 8.9 4.3 16.8 12 3.9 16.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BAF PF02961.14 EAK88461.1 - 0.098 13.1 0.0 0.41 11.1 0.0 2.1 1 0 0 1 1 1 0 Barrier to autointegration factor SDA1 PF05285.12 EAK88461.1 - 0.34 10.3 5.9 0.57 9.5 5.9 1.3 1 0 0 1 1 1 0 SDA1 YojJ PF10372.9 EAK88461.1 - 9.8 6.4 10.7 0.97 9.6 0.0 4.7 5 1 0 5 5 5 0 Bacterial membrane-spanning protein N-terminus CRAL_TRIO PF00650.20 EAK88462.1 - 9.7e-32 109.9 0.0 1.6e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EAK88462.1 - 0.0018 18.5 0.0 0.0039 17.4 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Peptidase_C97 PF05903.14 EAK88462.1 - 0.095 12.5 0.0 0.26 11.1 0.0 1.7 2 0 0 2 2 2 0 PPPDE putative peptidase domain Ydr279_N PF17745.1 EAK88463.1 - 2e-06 28.0 0.0 2.8e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain SF-assemblin PF06705.11 EAK88464.1 - 7.7e-10 38.5 17.1 1.3e-08 34.5 17.2 2.6 1 1 0 1 1 1 1 SF-assemblin/beta giardin GSIII_N PF12437.8 EAK88464.1 - 0.0091 15.7 0.9 0.026 14.2 0.1 2.1 2 0 0 2 2 2 1 Glutamine synthetase type III N terminal FAM25 PF15825.5 EAK88464.1 - 0.058 13.7 0.5 9 6.7 0.1 2.6 2 0 0 2 2 2 0 FAM25 family DUF2400 PF09674.10 EAK88464.1 - 0.24 11.3 11.7 0.15 12.1 3.5 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2400) DUF3037 PF11236.8 EAK88464.1 - 0.35 11.3 3.4 1.1 9.7 0.3 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) KELK PF15796.5 EAK88464.1 - 0.44 11.0 9.3 2.4 8.7 0.4 3.5 3 1 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase APG17 PF04108.12 EAK88464.1 - 0.46 9.5 14.9 0.093 11.8 0.9 3.0 1 1 0 3 3 3 0 Autophagy protein Apg17 GCN5L1 PF06320.13 EAK88464.1 - 0.46 10.6 10.5 1.7 8.8 1.5 3.2 2 1 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) Chalcone_2 PF16035.5 EAK88464.1 - 0.48 10.2 6.6 14 5.4 0.1 3.1 2 1 0 3 3 3 0 Chalcone isomerase like Tiam_CC_Ex PF18385.1 EAK88464.1 - 0.6 10.5 3.6 3.1 8.2 0.2 2.5 2 1 0 2 2 2 0 T-lymphoma invasion and metastasis CC-Ex domain DUF2383 PF09537.10 EAK88464.1 - 1.1 9.6 6.6 0.44 10.9 1.0 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF2383) DUF16 PF01519.16 EAK88464.1 - 1.2 9.6 18.2 0.072 13.6 5.2 3.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 PRANC PF09372.10 EAK88464.1 - 1.5 9.1 10.1 0.21 12.0 1.2 3.1 1 1 2 3 3 3 0 PRANC domain DUF1664 PF07889.12 EAK88464.1 - 3.2 7.8 14.5 13 5.9 0.7 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Nup54 PF13874.6 EAK88464.1 - 9.5 6.3 11.9 1.4 9.0 4.2 2.8 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 Pkinase PF00069.25 EAK88466.1 - 6e-55 186.5 0.3 1.2e-49 169.1 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88466.1 - 7.5e-22 77.8 0.2 1.4e-15 57.3 0.4 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EAK88466.1 - 0.004 17.1 2.5 0.013 15.4 0.9 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EAK88466.1 - 0.018 13.8 0.1 0.018 13.8 0.1 2.3 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 EAK88466.1 - 0.024 14.0 0.1 0.13 11.5 0.1 2.2 1 1 0 1 1 1 0 Kinase-like DUF2193 PF09959.9 EAK88467.1 - 0.14 10.6 0.0 0.19 10.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) SNF2_N PF00176.23 EAK88469.1 - 2.9e-55 187.4 0.0 4.8e-55 186.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK88469.1 - 5.4e-14 52.5 0.0 1.5e-13 51.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK88469.1 - 7.8e-12 45.5 0.0 1.9e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EAK88469.1 - 6.4e-06 26.1 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EAK88469.1 - 0.0017 18.1 0.1 0.004 16.9 0.0 1.6 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 EAK88469.1 - 0.0076 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PSS PF03034.15 EAK88472.1 - 3.9e-85 285.9 13.0 3.9e-85 285.9 13.0 1.8 2 0 0 2 2 2 1 Phosphatidyl serine synthase DUF4079 PF13301.6 EAK88472.1 - 0.017 15.3 0.3 0.017 15.3 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Peptidase_S15 PF02129.18 EAK88473.1 - 1.7e-30 106.6 0.4 1.1e-25 90.7 0.3 2.6 3 0 0 3 3 3 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EAK88473.1 - 9.1e-12 45.4 0.0 2.6e-11 43.9 0.0 1.6 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 EAK88473.1 - 0.00026 20.3 0.1 0.0021 17.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Cas_Cas6 PF01881.16 EAK88474.1 - 0.05 14.2 3.9 0.045 14.3 1.3 2.3 1 1 1 2 2 2 0 CRISPR associated protein Cas6 DUF4606 PF15379.6 EAK88474.1 - 0.068 13.4 2.1 0.15 12.3 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4606) TB2_DP1_HVA22 PF03134.19 EAK88475.1 - 5.6e-15 55.0 6.6 7.9e-15 54.6 6.6 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF5592 PF17332.2 EAK88475.1 - 1.1 9.9 6.6 1.1 9.8 1.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5592) DNA_repr_REX1B PF14966.6 EAK88477.1 - 0.98 10.1 4.5 0.47 11.1 0.4 2.7 3 0 0 3 3 3 0 DNA repair REX1-B DUF5412 PF17428.2 EAK88479.1 - 0.28 11.1 2.4 4 7.3 0.0 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5412) CEP63 PF17045.5 EAK88480.1 - 0.0014 18.5 14.3 0.12 12.3 3.8 2.3 2 0 0 2 2 2 2 Centrosomal protein of 63 kDa THP2 PF09432.10 EAK88480.1 - 0.022 14.8 2.1 0.022 14.8 2.1 2.2 2 1 0 2 2 2 0 Tho complex subunit THP2 Acetyltransf_11 PF13720.6 EAK88480.1 - 0.032 14.7 3.4 0.053 14.0 0.2 2.5 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Urocanase PF01175.18 EAK88480.1 - 0.1 12.3 0.7 0.23 11.1 0.6 1.6 1 1 0 1 1 1 0 Urocanase Rossmann-like domain Bap31_Bap29_C PF18035.1 EAK88480.1 - 0.15 12.1 0.1 0.15 12.1 0.1 4.0 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF641 PF04859.12 EAK88480.1 - 0.46 10.8 14.9 0.28 11.5 5.2 2.6 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) RPW8 PF05659.11 EAK88480.1 - 1 9.0 7.7 2.9 7.6 2.3 3.2 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 FliJ PF02050.16 EAK88480.1 - 1.7 8.9 18.6 1.5 9.0 5.8 2.6 2 1 0 2 2 2 0 Flagellar FliJ protein HIP1_clath_bdg PF16515.5 EAK88480.1 - 3.8 8.2 20.5 0.14 12.8 5.3 2.8 2 2 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 EAK88480.1 - 9.9 5.4 12.8 1.4 8.2 2.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Ank_2 PF12796.7 EAK88481.1 - 0.0028 18.2 0.3 0.058 14.0 0.4 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) DUF4690 PF15756.5 EAK88481.1 - 0.11 13.1 0.0 0.36 11.4 0.0 1.9 1 0 0 1 1 1 0 Small Novel Rich in Cartilage PNTB PF02233.16 EAK88482.1 - 9.2e-165 549.0 23.2 1.4e-164 548.4 15.4 2.2 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EAK88482.1 - 3.3e-54 183.4 0.0 6.7e-53 179.2 0.0 2.9 4 0 0 4 4 4 1 Alanine dehydrogenase/PNT, C-terminal domain PNTB_4TM PF12769.7 EAK88482.1 - 9e-27 93.4 4.8 9e-27 93.4 4.8 3.3 3 0 0 3 3 3 1 4TM region of pyridine nucleotide transhydrogenase, mitoch AlaDh_PNT_N PF05222.15 EAK88482.1 - 2e-18 67.0 0.0 4.1e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 EAK88482.1 - 6.9e-08 32.0 0.4 0.00015 21.2 0.1 3.7 1 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 EAK88482.1 - 0.0023 17.7 0.5 0.042 13.6 0.1 3.3 3 1 1 4 4 4 1 Thiamine pyrophosphate enzyme, central domain Shikimate_DH PF01488.20 EAK88482.1 - 0.006 16.7 1.8 0.96 9.5 0.5 3.9 3 1 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 EAK88482.1 - 0.0077 15.5 0.0 0.017 14.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EAK88482.1 - 0.017 14.2 0.3 0.042 12.9 0.1 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EAK88482.1 - 0.048 12.7 0.1 0.079 12.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain GLYCAM-1 PF05242.11 EAK88482.1 - 0.065 13.4 2.0 0.58 10.3 1.2 2.5 2 0 0 2 2 2 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) DUF5056 PF16479.5 EAK88482.1 - 0.083 13.1 1.5 0.24 11.7 0.1 2.6 2 0 0 2 2 1 0 Domain of unknown function (DUF5056) ADH_zinc_N PF00107.26 EAK88482.1 - 0.086 12.8 0.0 0.56 10.2 0.0 2.4 3 0 0 3 3 3 0 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 EAK88482.1 - 0.098 13.1 0.8 0.47 10.9 0.1 2.5 3 0 0 3 3 2 0 Putative NAD(P)-binding Prok-RING_4 PF14447.6 EAK88483.1 - 0.031 14.1 9.3 0.11 12.4 9.3 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EAK88483.1 - 0.034 14.5 12.2 0.17 12.2 12.2 2.3 1 0 0 1 1 1 0 Ring finger domain zf-RING_10 PF16685.5 EAK88483.1 - 0.19 11.9 7.6 0.65 10.2 7.6 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EAK88483.1 - 0.21 11.6 16.5 0.15 12.0 13.3 2.5 2 0 0 2 2 2 0 zinc-RING finger domain zf-MIZ PF02891.20 EAK88483.1 - 0.45 10.3 11.7 1.2 8.9 11.7 1.8 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.6 EAK88483.1 - 1.1 9.3 8.4 5.4 7.1 8.4 2.3 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EAK88484.1 - 0.36 10.8 14.3 0.078 12.9 10.0 2.1 2 1 1 3 3 3 0 zinc-RING finger domain Myc_target_1 PF15179.6 EAK88484.1 - 0.6 10.0 6.8 0.091 12.7 1.8 2.0 2 0 0 2 2 2 0 Myc target protein 1 Prok-RING_4 PF14447.6 EAK88484.1 - 0.7 9.8 11.0 6.9 6.6 11.0 2.4 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 LRR_9 PF14580.6 EAK88486.1 - 1.9e-16 60.1 3.3 8.8e-16 57.9 2.7 1.9 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EAK88486.1 - 1e-06 28.9 17.0 0.00062 20.1 3.0 3.8 1 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EAK88486.1 - 0.0017 18.1 13.0 0.017 14.9 4.9 3.4 1 1 3 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EAK88486.1 - 1.4 9.2 3.5 16 5.9 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Pro_isomerase PF00160.21 EAK88488.1 - 7.8e-39 133.5 0.2 9.4e-39 133.2 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF441 PF04284.13 EAK88488.1 - 0.18 11.8 0.2 0.24 11.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF441) AAA_12 PF13087.6 EAK88489.1 - 3.5e-62 209.6 0.1 1.2e-61 207.9 0.1 2.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EAK88489.1 - 1.3e-55 189.0 0.6 4.9e-28 98.6 0.2 2.9 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EAK88489.1 - 4.9e-09 36.2 0.0 5.1e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EAK88489.1 - 6.3e-08 33.1 0.0 0.0063 16.9 0.0 3.0 3 1 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EAK88489.1 - 1.5e-06 28.1 0.0 0.04 13.7 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA PF00004.29 EAK88489.1 - 0.0055 17.1 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 EAK88489.1 - 0.0097 15.7 0.0 0.035 13.9 0.0 2.0 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 EAK88489.1 - 0.039 13.2 0.1 0.48 9.6 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EAK88489.1 - 0.041 12.9 0.0 0.098 11.7 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 EAK88489.1 - 0.042 13.8 0.1 0.44 10.4 0.1 2.7 2 0 0 2 2 2 0 Rad17 P-loop domain ResIII PF04851.15 EAK88489.1 - 0.062 13.3 0.1 0.33 10.9 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 EAK88489.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Phage-scaffold PF09306.10 EAK88489.1 - 0.1 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein AAA_14 PF13173.6 EAK88489.1 - 0.1 12.6 0.3 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EAK88489.1 - 0.11 12.3 0.1 0.28 11.0 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EAK88489.1 - 0.12 11.9 0.1 0.52 9.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region UvrD-helicase PF00580.21 EAK88489.1 - 1.9 7.9 6.7 2.1 7.8 0.2 3.1 3 1 0 3 3 3 0 UvrD/REP helicase N-terminal domain DHHC PF01529.20 EAK88490.1 - 2.5e-29 102.1 11.9 2.5e-29 102.1 11.9 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EAK88490.1 - 3.9e-17 62.6 0.1 7.3e-09 36.1 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK88490.1 - 1.1e-15 57.7 2.9 5.7e-07 30.0 0.1 4.6 1 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAK88490.1 - 9.1e-11 41.0 0.1 0.0041 17.5 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EAK88490.1 - 7.3e-07 29.4 0.2 0.15 12.5 0.0 3.7 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EAK88490.1 - 8.6e-07 29.1 0.9 0.043 14.3 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat NIF PF03031.18 EAK88492.1 - 0.0076 16.0 0.0 0.03 14.1 0.0 1.8 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BsuBI_PstI_RE PF06616.11 EAK88492.1 - 0.088 12.1 0.1 3.2 7.0 0.0 2.2 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain Pkinase PF00069.25 EAK88493.1 - 1.6e-47 162.1 0.2 3.2e-47 161.1 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88493.1 - 1.1e-22 80.6 0.1 1.8e-22 79.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase CdiI_2 PF18593.1 EAK88493.1 - 0.039 14.6 0.5 2.7 8.7 0.2 2.6 2 0 0 2 2 2 0 CdiI immunity protein Peptidase_S41_N PF11918.8 EAK88493.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Glyoxalase_2 PF12681.7 EAK88493.1 - 0.2 11.6 2.2 3 7.8 0.0 3.1 3 0 0 3 3 3 0 Glyoxalase-like domain Thioredoxin PF00085.20 EAK88494.1 - 8.6e-39 131.7 0.0 3.4e-20 72.0 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EAK88494.1 - 2.8e-11 43.7 11.5 4.3e-08 33.3 0.3 4.1 2 2 1 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EAK88494.1 - 2.8e-06 27.8 0.0 0.041 14.3 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EAK88494.1 - 5e-06 26.1 0.4 0.071 12.4 0.0 2.9 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EAK88494.1 - 2e-05 24.5 0.1 0.039 13.9 0.0 2.9 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 EAK88494.1 - 0.00015 21.5 0.0 0.044 13.5 0.0 2.8 2 0 0 2 2 2 1 Redoxin Thioredoxin_7 PF13899.6 EAK88494.1 - 0.00027 21.1 0.0 0.037 14.2 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 EAK88494.1 - 0.00096 19.4 6.7 0.078 13.3 0.0 4.8 5 1 0 5 5 5 1 Thioredoxin-like DUF3439 PF11921.8 EAK88494.1 - 0.11 12.5 1.4 0.28 11.2 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Glutaredoxin PF00462.24 EAK88494.1 - 0.15 12.3 2.5 3.6 7.9 0.5 2.8 2 1 0 2 2 2 0 Glutaredoxin LRR_6 PF13516.6 EAK88495.1 - 0.27 11.4 1.2 5.2 7.4 0.1 3.5 2 0 0 2 2 2 0 Leucine Rich repeat SPC25 PF06703.11 EAK88496.1 - 4.4e-05 23.3 1.5 0.00032 20.5 1.5 2.1 1 1 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF1011 PF06237.12 EAK88496.1 - 0.14 12.5 0.2 0.2 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1011) DUF1474 PF07342.11 EAK88497.1 - 0.03 14.9 5.0 1.1 9.9 0.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1474) ATP13 PF12921.7 EAK88497.1 - 0.038 13.9 1.6 0.55 10.1 0.1 2.7 2 0 0 2 2 2 0 Mitochondrial ATPase expression AAA_6 PF12774.7 EAK88498.1 - 4.1e-134 446.7 2.2 3.9e-130 433.6 0.1 4.4 4 0 0 4 4 4 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EAK88498.1 - 8.7e-89 298.4 20.5 1.5e-79 268.0 9.8 7.4 8 1 1 9 9 9 2 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 EAK88498.1 - 6.5e-81 272.7 7.0 6.5e-81 272.7 7.0 3.7 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 EAK88498.1 - 1.1e-68 230.7 0.1 1.1e-68 230.7 0.1 4.3 4 0 0 4 4 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 EAK88498.1 - 6.8e-52 176.4 4.0 9.9e-52 175.8 0.0 3.3 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EAK88498.1 - 4.4e-41 140.4 0.3 4.3e-32 111.1 0.0 5.5 5 0 0 5 5 5 2 P-loop containing dynein motor region MT PF12777.7 EAK88498.1 - 1.8e-32 112.7 7.8 4.1e-32 111.6 7.8 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EAK88498.1 - 4.3e-32 111.0 0.0 6e-12 45.7 0.0 6.5 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 EAK88498.1 - 1.7e-30 106.0 0.0 5.1e-30 104.4 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EAK88498.1 - 2e-21 76.8 0.9 3.1e-05 24.4 0.0 7.1 6 0 0 6 6 6 3 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 EAK88498.1 - 5.1e-21 75.0 0.0 5.1e-20 71.7 0.1 2.8 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_C PF18199.1 EAK88498.1 - 7.1e-16 58.3 0.0 7.1e-16 58.3 0.0 2.7 3 0 0 3 3 2 1 Dynein heavy chain C-terminal domain AAA_22 PF13401.6 EAK88498.1 - 1.5e-15 57.7 0.2 0.018 15.3 0.0 6.4 6 0 0 6 6 5 4 AAA domain Dynein_AAA_lid PF17852.1 EAK88498.1 - 4e-11 43.1 1.3 1.3e-10 41.4 0.2 2.7 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 EAK88498.1 - 2.9e-10 40.8 0.0 0.17 12.2 0.0 5.2 4 0 0 4 4 4 1 AAA ATPase domain AAA_18 PF13238.6 EAK88498.1 - 7e-08 33.1 0.1 3.8 8.1 0.0 5.7 4 0 0 4 4 4 1 AAA domain AAA_33 PF13671.6 EAK88498.1 - 2.3e-07 31.1 0.1 1.6 8.9 0.0 5.0 4 0 0 4 4 4 2 AAA domain Mg_chelatase PF01078.21 EAK88498.1 - 5.9e-07 29.1 1.6 0.11 11.9 0.2 4.3 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EAK88498.1 - 1.5e-06 27.5 0.0 0.12 11.4 0.1 3.7 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_19 PF13245.6 EAK88498.1 - 8.3e-06 26.2 6.3 0.45 10.8 0.0 5.8 6 0 0 6 6 5 1 AAA domain AAA_25 PF13481.6 EAK88498.1 - 2.3e-05 24.1 0.3 0.1 12.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 EAK88498.1 - 4.8e-05 23.2 0.2 0.11 12.2 0.0 4.1 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EAK88498.1 - 7.1e-05 23.2 0.5 22 5.5 0.0 5.5 5 0 0 5 5 4 0 RNA helicase AAA_24 PF13479.6 EAK88498.1 - 0.00013 21.7 1.0 23 4.6 0.1 5.6 5 0 0 5 5 5 0 AAA domain AAA_30 PF13604.6 EAK88498.1 - 0.00014 21.6 1.2 7.4 6.2 0.0 4.2 4 0 0 4 4 4 0 AAA domain IstB_IS21 PF01695.17 EAK88498.1 - 0.00081 19.2 0.8 9.3 5.9 0.0 4.3 4 0 0 4 4 4 0 IstB-like ATP binding protein TrwB_AAD_bind PF10412.9 EAK88498.1 - 0.00082 18.4 0.7 0.078 11.9 0.1 3.7 4 0 0 4 4 4 1 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 EAK88498.1 - 0.0016 17.8 0.0 0.79 9.0 0.1 3.6 3 0 0 3 3 3 1 FtsK/SpoIIIE family NACHT PF05729.12 EAK88498.1 - 0.0017 18.3 2.8 32 4.4 0.0 5.6 5 0 0 5 5 4 0 NACHT domain Zeta_toxin PF06414.12 EAK88498.1 - 0.0023 17.2 0.0 6.3 6.0 0.0 3.7 4 0 0 4 4 4 0 Zeta toxin ABC_tran PF00005.27 EAK88498.1 - 0.0033 17.9 16.9 0.63 10.6 0.1 5.8 5 0 0 5 5 4 1 ABC transporter PduV-EutP PF10662.9 EAK88498.1 - 0.0074 16.0 1.2 0.39 10.5 0.2 3.6 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.15 EAK88498.1 - 0.0098 15.9 3.3 0.22 11.5 0.1 4.5 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit AAA_lid_1 PF17857.1 EAK88498.1 - 0.024 14.8 0.1 0.13 12.5 0.1 2.3 1 0 0 1 1 1 0 AAA+ lid domain TsaE PF02367.17 EAK88498.1 - 0.035 14.1 6.1 0.69 9.9 0.1 5.0 5 0 0 5 5 5 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE POT1PC PF16686.5 EAK88498.1 - 0.045 13.6 0.1 0.19 11.6 0.0 2.1 2 0 0 2 2 1 0 ssDNA-binding domain of telomere protection protein AAA_28 PF13521.6 EAK88498.1 - 0.047 13.9 4.3 69 3.6 0.4 5.0 5 0 0 5 5 5 0 AAA domain cobW PF02492.19 EAK88498.1 - 0.098 12.2 1.3 5.7 6.5 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EAK88498.1 - 9.4 6.7 7.5 38 4.7 0.0 4.9 5 0 0 5 5 4 0 AAA domain Glu_cyclase_2 PF05096.12 EAK88499.1 - 1.4e-45 155.7 0.0 2.8e-45 154.7 0.0 1.4 1 1 0 1 1 1 1 Glutamine cyclotransferase Ins134_P3_kin PF05770.11 EAK88500.1 - 0.065 12.7 0.0 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain FYDLN_acid PF09538.10 EAK88503.1 - 0.023 15.3 1.7 0.023 15.3 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PilM PF07419.12 EAK88504.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 PilM DUF501 PF04417.12 EAK88504.1 - 0.24 11.2 5.0 0.36 10.6 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF501) Ecotin PF03974.13 EAK88505.1 - 0.049 13.6 0.3 0.09 12.8 0.3 1.4 1 0 0 1 1 1 0 Ecotin DUF5470 PF17564.2 EAK88505.1 - 0.13 12.5 3.9 0.42 10.9 1.3 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5470) Sec66 PF09802.9 EAK88506.1 - 9e-06 25.4 3.8 1.3e-05 24.9 3.8 1.3 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF4271 PF14093.6 EAK88506.1 - 0.018 15.0 0.7 0.028 14.3 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) TssO PF17561.2 EAK88506.1 - 0.061 13.4 0.5 0.061 13.4 0.5 3.2 3 0 0 3 3 3 0 Type VI secretion system, TssO DUF4061 PF13270.6 EAK88506.1 - 0.1 12.9 7.4 0.056 13.8 5.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) AF0941-like PF14591.6 EAK88509.1 - 0.034 14.7 1.4 0.078 13.5 1.4 1.6 1 0 0 1 1 1 0 AF0941-like Synaptobrevin PF00957.21 EAK88509.1 - 0.082 12.7 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Synaptobrevin Exonuc_VII_L PF02601.15 EAK88509.1 - 0.6 9.6 7.2 2.7 7.5 0.1 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit TelA PF05816.11 EAK88509.1 - 1.1 8.2 6.0 2.2 7.3 2.0 2.2 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) SKA1 PF07160.12 EAK88509.1 - 1.5 8.6 12.7 2.1 8.1 6.6 2.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 GCIP PF13324.6 EAK88509.1 - 7.6 6.1 20.9 0.77 9.3 3.6 3.0 2 1 0 2 2 2 0 Grap2 and cyclin-D-interacting ATP-synt_C PF00137.21 EAK88511.1 - 2.8e-28 98.0 38.2 4e-17 62.3 15.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C PT-VENN PF04829.13 EAK88511.1 - 0.56 10.3 5.0 1.8 8.7 5.0 1.9 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif SHR3_chaperone PF08229.11 EAK88511.1 - 1.5 7.8 4.5 2.2 7.2 4.5 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 G0-G1_switch_2 PF15103.6 EAK88511.1 - 8.5 6.9 5.1 0.92 10.0 0.2 1.9 2 0 0 2 2 2 0 G0/G1 switch protein 2 Borrelia_P13 PF05628.12 EAK88512.1 - 0.21 11.6 1.1 0.54 10.2 0.7 1.8 2 0 0 2 2 2 0 Borrelia membrane protein P13 Maelstrom PF13017.6 EAK88514.1 - 0.079 12.6 0.1 2.4 7.7 0.0 2.0 2 0 0 2 2 2 0 piRNA pathway germ-plasm component PyrI PF01948.18 EAK88515.1 - 0.0086 16.3 1.4 0.019 15.2 0.1 1.9 1 1 1 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain Pkinase PF00069.25 EAK88517.1 - 1.2e-28 100.2 0.7 1.2e-28 100.2 0.7 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88517.1 - 0.00052 19.4 0.1 0.015 14.6 0.0 2.8 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK88517.1 - 0.0035 16.7 0.0 0.078 12.3 0.0 2.7 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 EAK88517.1 - 0.049 13.2 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Josephin PF02099.17 EAK88518.1 - 2.2e-42 144.9 0.9 7.9e-42 143.1 0.0 2.0 2 1 0 2 2 2 1 Josephin UBX PF00789.20 EAK88518.1 - 9.9e-07 28.9 0.1 5.3e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 UBX domain JHY PF15261.6 EAK88518.1 - 0.00065 20.4 0.7 0.0025 18.5 0.1 2.1 2 1 0 2 2 2 1 Jhy protein G10 PF01125.17 EAK88518.1 - 0.11 12.2 0.2 0.45 10.3 0.1 2.0 2 0 0 2 2 2 0 G10 protein RRM_1 PF00076.22 EAK88519.1 - 0.0015 18.4 0.0 0.44 10.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M14 PF00246.24 EAK88520.1 - 6.9e-46 157.3 0.0 1.1e-45 156.6 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Orf78 PF06024.12 EAK88520.1 - 2.1 8.7 4.7 0.92 9.8 1.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Noc2 PF03715.13 EAK88521.1 - 3e-28 98.9 11.4 3e-28 98.9 11.4 1.9 2 0 0 2 2 2 1 Noc2p family Sec23_helical PF04815.15 EAK88521.1 - 0.083 12.7 1.4 0.48 10.3 0.1 2.8 3 0 0 3 3 3 0 Sec23/Sec24 helical domain adh_short PF00106.25 EAK88523.1 - 1.2e-31 109.7 0.0 1.7e-30 106.0 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EAK88523.1 - 1.9e-17 63.6 0.0 4e-17 62.6 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EAK88523.1 - 1.5e-08 34.8 0.0 2.4e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EAK88523.1 - 0.073 12.5 0.0 0.17 11.3 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TB2_DP1_HVA22 PF03134.19 EAK88526.1 - 0.00091 19.1 7.7 0.0013 18.6 7.3 1.5 1 1 0 1 1 1 1 TB2/DP1, HVA22 family Peptidase_C13 PF01650.18 EAK88527.1 - 3.4e-38 131.6 0.8 5.5e-38 130.9 0.8 1.4 1 0 0 1 1 1 1 Peptidase C13 family DUF5502 PF17606.2 EAK88527.1 - 0.32 11.7 2.4 0.66 10.7 0.4 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5502) Fe_hyd_lg_C PF02906.14 EAK88528.1 - 3.9e-46 157.7 0.2 2.2e-45 155.3 0.2 2.0 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain MRG PF05712.13 EAK88528.1 - 0.052 12.8 0.5 0.14 11.4 0.5 1.7 1 0 0 1 1 1 0 MRG Trimer_CC PF08954.11 EAK88529.1 - 0.039 13.5 0.2 0.15 11.7 0.2 2.0 1 0 0 1 1 1 0 Trimerisation motif TAF6_C PF07571.13 EAK88532.1 - 0.00026 21.3 0.0 0.00068 19.9 0.0 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EAK88532.1 - 0.0055 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) NLRC4_HD2 PF17776.1 EAK88536.1 - 0.8 10.2 6.8 0.19 12.2 1.0 2.6 2 0 0 2 2 2 0 NLRC4 helical domain HD2 FtsH_ext PF06480.15 EAK88538.1 - 0.1 13.0 1.7 0.33 11.3 0.1 2.2 2 0 0 2 2 2 0 FtsH Extracellular DUF2098 PF09871.9 EAK88538.1 - 1.4 9.4 5.5 0.91 9.9 0.4 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) UAA PF08449.11 EAK88539.1 - 1.7e-45 155.6 26.7 4.1e-45 154.3 26.7 1.6 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EAK88539.1 - 2.4e-08 34.2 10.9 2.4e-08 34.2 10.9 3.2 3 1 0 3 3 3 2 EamA-like transporter family TPT PF03151.16 EAK88539.1 - 0.00086 18.7 15.4 0.021 14.2 4.7 2.2 1 1 1 2 2 2 2 Triose-phosphate Transporter family TPR_2 PF07719.17 EAK88541.1 - 2.8e-09 36.4 0.6 2.6e-05 24.0 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EAK88541.1 - 4.3e-08 32.6 4.1 4.1e-07 29.6 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAK88541.1 - 0.0011 19.0 1.2 0.03 14.5 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EAK88541.1 - 0.0031 17.8 0.0 0.067 13.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Methyltransf_28 PF02636.17 EAK88541.1 - 0.0032 17.2 0.1 0.015 15.0 0.1 1.9 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase ANAPC3 PF12895.7 EAK88541.1 - 0.009 16.2 0.1 0.026 14.8 0.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EAK88541.1 - 0.011 15.7 0.0 0.046 13.8 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EAK88541.1 - 0.06 14.2 0.0 9.1 7.4 0.0 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EAK88541.1 - 0.16 12.4 1.7 4.8 7.8 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat MAGI_u1 PF16663.5 EAK88541.1 - 0.17 12.0 0.1 0.56 10.3 0.1 1.9 2 0 0 2 2 2 0 Unstructured region on MAGI PKD_channel PF08016.12 EAK88542.1 - 0.0049 15.6 51.7 0.092 11.4 17.9 3.1 2 0 0 2 2 2 2 Polycystin cation channel EGF PF00008.27 EAK88545.1 - 4.8e-14 52.3 36.6 1.5e-05 25.2 6.4 3.4 3 0 0 3 3 3 3 EGF-like domain EGF_2 PF07974.13 EAK88545.1 - 9.7e-09 35.4 41.8 0.00049 20.4 10.2 3.4 3 0 0 3 3 3 3 EGF-like domain EGF_3 PF12947.7 EAK88545.1 - 9.8e-05 22.5 34.4 0.023 14.9 4.8 3.5 3 0 0 3 3 3 3 EGF domain Plasmod_Pvs28 PF06247.11 EAK88545.1 - 0.00015 22.0 3.0 0.00015 22.0 3.0 3.9 2 2 1 3 3 3 2 Pvs28 EGF domain hEGF PF12661.7 EAK88545.1 - 0.0052 17.4 31.5 0.013 16.1 4.1 4.5 4 1 0 4 4 4 3 Human growth factor-like EGF Smim3 PF17307.2 EAK88545.1 - 0.12 11.8 0.8 0.23 11.0 0.8 1.4 1 0 0 1 1 1 0 Small integral membrane protein 3 F_actin_cap_B PF01115.17 EAK88546.1 - 4.9e-33 114.7 19.5 1.1e-32 113.6 19.5 1.5 1 1 0 1 1 1 1 F-actin capping protein, beta subunit Kelch_3 PF13415.6 EAK88546.1 - 0.075 13.3 2.6 1.4 9.3 0.2 2.5 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 EAK88546.1 - 0.19 11.3 1.0 0.52 9.9 1.0 1.8 1 0 0 1 1 1 0 Kelch motif Hydrolase_3 PF08282.12 EAK88547.1 - 5.9e-43 147.4 0.3 8.4e-43 146.9 0.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EAK88547.1 - 1.9e-15 57.1 0.3 1.1e-11 44.7 0.1 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EAK88547.1 - 2.7e-06 27.8 0.0 2.3e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EAK88547.1 - 0.0017 18.5 0.3 0.21 11.7 0.0 2.9 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EAK88547.1 - 0.051 14.0 0.0 4 7.8 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 EAK88547.1 - 0.056 12.6 0.1 0.13 11.3 0.0 1.6 2 0 0 2 2 2 0 Trehalose-phosphatase Hydrolase_like PF13242.6 EAK88547.1 - 0.072 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Dus PF01207.17 EAK88548.1 - 4e-71 239.7 0.0 5.6e-71 239.2 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EAK88548.1 - 2.7e-08 33.5 0.0 4.7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 EAK88548.1 - 0.00063 19.1 0.0 0.00092 18.6 0.0 1.1 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EAK88548.1 - 0.0056 15.7 0.1 0.008 15.2 0.1 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain G3P_antiterm PF04309.12 EAK88548.1 - 0.053 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator NMO PF03060.15 EAK88548.1 - 0.18 11.1 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Sld5 PF05916.11 EAK88549.1 - 3.7e-08 33.8 0.0 4.1e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein AAA PF00004.29 EAK88550.1 - 8.1e-42 142.8 0.3 7.1e-41 139.7 0.0 2.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EAK88550.1 - 2e-14 53.3 0.1 6.2e-14 51.7 0.1 1.9 1 1 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EAK88550.1 - 4.1e-12 46.0 0.8 1e-11 44.7 0.8 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 EAK88550.1 - 3.1e-09 36.8 0.0 8.2e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EAK88550.1 - 4.6e-07 30.1 0.0 1e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EAK88550.1 - 2e-05 25.0 0.1 0.0001 22.7 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EAK88550.1 - 2e-05 24.9 1.7 0.087 13.1 0.1 2.9 2 1 1 3 3 3 2 AAA domain AAA_5 PF07728.14 EAK88550.1 - 7.3e-05 22.8 0.1 0.0003 20.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EAK88550.1 - 0.0001 22.0 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 EAK88550.1 - 0.00026 21.0 0.0 0.00084 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EAK88550.1 - 0.00042 20.0 0.6 0.051 13.1 0.2 2.3 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 EAK88550.1 - 0.0005 19.5 1.7 0.18 11.2 0.0 3.0 2 2 1 3 3 3 2 KaiC DUF815 PF05673.13 EAK88550.1 - 0.0006 19.1 0.1 0.0044 16.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EAK88550.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EAK88550.1 - 0.0012 19.2 2.5 0.0026 18.1 0.1 2.8 3 1 0 3 3 2 1 RNA helicase TIP49 PF06068.13 EAK88550.1 - 0.0021 17.3 0.0 0.005 16.1 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 EAK88550.1 - 0.0057 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EAK88550.1 - 0.0061 16.7 0.0 0.016 15.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EAK88550.1 - 0.0099 15.3 0.6 0.075 12.5 0.2 2.4 2 1 0 2 2 2 1 PhoH-like protein AAA_18 PF13238.6 EAK88550.1 - 0.015 15.8 0.2 0.066 13.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EAK88550.1 - 0.021 14.2 0.0 6.9 6.0 0.0 2.6 1 1 0 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 EAK88550.1 - 0.026 13.9 0.1 0.06 12.7 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EAK88550.1 - 0.036 13.6 0.0 0.077 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EAK88550.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 EAK88550.1 - 0.078 12.8 0.1 1.6 8.5 0.1 2.4 1 1 0 1 1 1 0 Bacterial dnaA protein NACHT PF05729.12 EAK88550.1 - 0.091 12.7 0.1 1.6 8.6 0.0 2.4 1 1 1 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EAK88550.1 - 0.11 11.7 0.0 0.37 10.0 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.6 EAK88550.1 - 0.15 12.4 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EAK88551.1 - 8.6e-31 107.3 0.0 4.2e-30 105.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88551.1 - 3.8e-08 32.9 0.0 4.4e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase ADK PF00406.22 EAK88552.1 - 6.1e-43 146.5 0.0 7.4e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EAK88552.1 - 1.3e-29 103.4 0.0 1.7e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EAK88552.1 - 5.2e-08 33.5 0.0 8.5e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EAK88552.1 - 1.1e-05 25.7 0.0 1.7e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EAK88552.1 - 0.0025 17.5 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 1 Thymidylate kinase Cytidylate_kin PF02224.18 EAK88552.1 - 0.022 14.5 0.0 0.53 10.0 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase AAA PF00004.29 EAK88552.1 - 0.041 14.3 0.0 0.11 12.9 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF5024 PF16427.5 EAK88552.1 - 0.1 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5024) Zeta_toxin PF06414.12 EAK88552.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin 14-3-3 PF00244.20 EAK88553.1 - 9.3e-41 139.8 6.1 1.1e-40 139.5 6.1 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF2225 PF09986.9 EAK88553.1 - 0.0057 16.4 3.1 0.03 14.0 0.5 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_12 PF13424.6 EAK88553.1 - 0.015 15.6 0.1 0.072 13.4 0.2 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EAK88553.1 - 0.017 15.9 0.2 5.1 8.2 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EAK88553.1 - 0.018 14.8 2.5 4 7.4 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat CNOT1_TTP_bind PF16417.5 EAK88553.1 - 0.026 13.7 0.5 0.042 13.0 0.0 1.6 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 TTP binding domain TPR_8 PF13181.6 EAK88553.1 - 0.048 13.9 0.3 8.2 6.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EAK88553.1 - 0.069 13.3 2.9 4.5 7.6 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat RRM_1 PF00076.22 EAK88554.1 - 9.7e-05 22.1 0.0 0.00023 20.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3195 PF11424.8 EAK88554.1 - 0.2 11.8 0.7 27 4.9 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3195) Glycolytic PF00274.19 EAK88555.1 - 8.1e-162 537.8 0.0 9.2e-162 537.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Peptidase_M61 PF05299.12 EAK88555.1 - 0.17 12.3 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 M61 glycyl aminopeptidase Ribosomal_L27e PF01777.18 EAK88556.1 - 2.3e-20 72.7 0.8 3.6e-20 72.1 0.8 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EAK88556.1 - 0.0021 17.9 0.2 0.0035 17.2 0.2 1.4 1 0 0 1 1 1 1 KOW motif ATHILA PF03078.15 EAK88556.1 - 0.04 12.7 0.0 0.051 12.4 0.0 1.1 1 0 0 1 1 1 0 ATHILA ORF-1 family Pkinase PF00069.25 EAK88557.1 - 2.4e-33 115.6 0.0 9.4e-19 67.8 0.0 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88557.1 - 1.9e-07 30.7 0.0 0.022 14.0 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase CPSF_A PF03178.15 EAK88559.1 - 4.9e-31 108.2 1.8 1.3e-22 80.5 0.0 3.3 3 0 0 3 3 3 2 CPSF A subunit region MMS1_N PF10433.9 EAK88559.1 - 1.1e-23 83.7 0.7 8.9e-22 77.4 1.3 2.3 2 0 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term SNARE PF05739.19 EAK88560.1 - 2.1e-13 50.0 0.1 5.9e-13 48.6 0.1 1.8 1 0 0 1 1 1 1 SNARE domain Prominin PF05478.11 EAK88560.1 - 5.9e-06 24.6 8.4 0.0022 16.0 0.4 2.0 2 0 0 2 2 2 2 Prominin Syntaxin PF00804.25 EAK88560.1 - 1.7e-05 24.6 9.6 0.02 14.6 3.3 2.3 2 0 0 2 2 2 2 Syntaxin DUF5082 PF16888.5 EAK88560.1 - 0.0028 17.9 10.3 0.056 13.7 4.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5082) KxDL PF10241.9 EAK88560.1 - 0.0059 16.9 11.0 0.013 15.8 1.6 3.0 3 0 0 3 3 3 1 Uncharacterized conserved protein AI-2E_transport PF01594.16 EAK88560.1 - 0.0075 15.5 6.4 0.014 14.5 0.3 2.7 2 1 0 2 2 2 1 AI-2E family transporter FAM184 PF15665.5 EAK88560.1 - 0.013 15.3 0.5 0.013 15.3 0.5 2.1 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Corona_S2 PF01601.16 EAK88560.1 - 0.02 13.4 8.1 0.063 11.8 1.9 2.1 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein SH3BP5 PF05276.14 EAK88560.1 - 0.029 14.2 3.5 0.36 10.6 0.4 2.4 2 1 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) Syntaxin-6_N PF09177.11 EAK88560.1 - 0.042 14.4 5.1 1.9 9.1 2.3 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Goodbye PF17109.5 EAK88560.1 - 0.047 14.1 1.9 1.1 9.8 0.1 2.6 2 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain Lipoprotein_7 PF01540.16 EAK88560.1 - 0.053 12.8 1.5 0.3 10.3 0.1 2.3 3 0 0 3 3 3 0 Adhesin lipoprotein Syntaxin_2 PF14523.6 EAK88560.1 - 0.063 13.7 12.9 0.061 13.7 6.5 2.9 3 1 0 3 3 2 0 Syntaxin-like protein CLZ PF16526.5 EAK88560.1 - 0.12 12.8 5.2 2.2 8.7 0.1 3.0 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CcdA PF07362.12 EAK88560.1 - 0.13 12.7 1.6 1 9.8 0.0 2.7 3 0 0 3 3 2 0 Post-segregation antitoxin CcdA Phage_HK97_TLTM PF06120.11 EAK88560.1 - 0.22 10.6 4.9 0.067 12.4 0.5 2.0 2 0 0 2 2 2 0 Tail length tape measure protein Vac_Fusion PF02346.16 EAK88560.1 - 0.26 10.9 3.8 2.2 8.0 0.0 3.5 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Tweety PF04906.13 EAK88560.1 - 0.63 8.6 3.9 5.3 5.6 0.7 2.3 2 1 0 2 2 2 0 Tweety Laminin_II PF06009.12 EAK88560.1 - 0.68 9.9 5.4 1.9 8.5 1.4 2.5 2 0 0 2 2 2 0 Laminin Domain II DUF3456 PF11938.8 EAK88560.1 - 0.73 10.3 2.8 27 5.3 0.1 2.4 2 1 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP DUF948 PF06103.11 EAK88560.1 - 0.75 10.1 8.7 21 5.5 0.1 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 EAK88560.1 - 0.84 9.4 8.0 1.2 8.9 0.9 2.5 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 EAK88560.1 - 0.94 9.5 10.0 1.9 8.5 0.4 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 EAK88560.1 - 1.1 9.1 7.8 2.7 7.8 2.4 2.7 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4795 PF16043.5 EAK88560.1 - 2.8 7.5 10.8 0.25 10.9 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) DNA_repr_REX1B PF14966.6 EAK88560.1 - 3 8.6 8.4 1.2 9.8 1.0 3.1 2 1 1 3 3 3 0 DNA repair REX1-B DASH_Dad1 PF08649.10 EAK88560.1 - 4 7.7 10.0 5.1 7.4 0.6 3.4 3 1 0 3 3 3 0 DASH complex subunit Dad1 Tup_N PF08581.10 EAK88560.1 - 4.4 7.7 10.9 0.46 10.8 2.4 2.8 2 1 0 2 2 2 0 Tup N-terminal BLOC1_2 PF10046.9 EAK88560.1 - 5.3 7.4 11.3 6.5 7.1 2.6 2.9 3 0 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG2 PF06148.11 EAK88560.1 - 6.5 6.8 7.6 18 5.4 0.1 3.0 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF745 PF05335.13 EAK88560.1 - 7.6 6.2 8.6 3.1 7.5 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Fib_alpha PF08702.10 EAK88560.1 - 9 6.5 11.5 11 6.2 0.3 2.8 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Noelin-1 PF12308.8 EAK88560.1 - 9.9 6.2 9.0 13 5.9 1.1 3.0 2 1 1 3 3 3 0 Neurogenesis glycoprotein YchF-GTPase_C PF06071.13 EAK88561.1 - 2.3e-39 133.4 0.1 7.5e-39 131.8 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EAK88561.1 - 7.2e-21 74.4 0.0 3.6e-20 72.2 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAK88561.1 - 8.5e-07 28.6 0.0 3.1e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.21 EAK88561.1 - 0.037 14.1 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 TGS domain AAA PF00004.29 EAK88561.1 - 0.058 13.8 0.0 0.15 12.5 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) zf-ANAPC11 PF12861.7 EAK88562.1 - 5.5e-27 93.7 7.2 7.2e-27 93.3 7.2 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EAK88562.1 - 3.8e-20 71.9 11.9 6.9e-20 71.1 11.9 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EAK88562.1 - 1.2e-07 31.9 16.0 2.6e-06 27.7 15.5 2.4 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EAK88562.1 - 1.7e-05 24.7 11.5 3.2e-05 23.8 9.7 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAK88562.1 - 3.6e-05 23.6 7.8 3.6e-05 23.6 7.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EAK88562.1 - 0.00018 21.3 15.0 0.0015 18.4 14.9 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EAK88562.1 - 0.00066 19.8 3.3 0.00066 19.8 3.3 2.8 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EAK88562.1 - 0.0032 17.2 12.2 0.025 14.4 8.8 2.4 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 EAK88562.1 - 0.0044 16.8 8.0 0.0044 16.8 8.0 2.9 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAK88562.1 - 0.0068 16.2 13.6 0.025 14.4 8.1 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 EAK88562.1 - 0.024 14.5 0.4 0.062 13.2 0.0 1.9 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Nse PF11789.8 EAK88562.1 - 0.026 14.3 4.7 0.046 13.5 4.7 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-HIT PF04438.16 EAK88562.1 - 0.044 13.7 1.9 0.044 13.7 1.9 2.5 3 0 0 3 3 2 0 HIT zinc finger zf-RING_11 PF17123.5 EAK88562.1 - 0.063 13.0 17.6 0.11 12.2 13.9 2.7 2 1 0 2 2 2 0 RING-like zinc finger Pellino PF04710.14 EAK88562.1 - 0.14 10.8 3.5 0.19 10.4 3.2 1.4 1 1 0 1 1 1 0 Pellino Zn-C2H2_12 PF18112.1 EAK88562.1 - 0.27 11.7 0.3 0.27 11.7 0.3 3.3 3 1 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain TerY_C PF15616.6 EAK88562.1 - 0.54 10.4 10.8 12 6.0 10.8 2.4 1 1 0 1 1 1 0 TerY-C metal binding domain FANCL_C PF11793.8 EAK88562.1 - 0.71 10.1 14.4 7.1 6.9 14.2 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EAK88562.1 - 5.4 6.7 13.1 0.08 12.6 4.4 2.2 1 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Acetyltransf_1 PF00583.25 EAK88563.1 - 2.4e-15 56.8 0.0 3e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EAK88563.1 - 1.2e-10 41.4 0.0 1.4e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EAK88563.1 - 1.7e-09 38.0 0.0 2.4e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EAK88563.1 - 4.3e-06 26.9 0.1 5.3e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EAK88563.1 - 0.00011 22.1 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EAK88563.1 - 0.01 15.9 0.0 0.017 15.2 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Sua5_yciO_yrdC PF01300.18 EAK88564.1 - 1e-46 158.7 0.0 1.4e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EAK88564.1 - 8.3e-11 42.6 0.0 1.5e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding LSM PF01423.22 EAK88565.1 - 8.2e-16 57.5 0.0 1.1e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EAK88565.1 - 0.0014 18.7 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain Mito_carr PF00153.27 EAK88566.1 - 4.8e-46 154.6 2.3 2.2e-17 62.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1664 PF07889.12 EAK88567.1 - 0.09 12.8 6.3 0.32 11.1 5.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 EAK88567.1 - 0.12 12.8 19.0 0.035 14.5 15.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DHR10 PF18595.1 EAK88567.1 - 1.7 8.7 19.8 0.25 11.4 15.4 1.9 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DDE_Tnp_1 PF01609.21 EAK88567.1 - 3.1 7.4 7.8 0.27 10.9 2.5 1.9 2 0 0 2 2 2 0 Transposase DDE domain SlyX PF04102.12 EAK88567.1 - 3.6 8.3 15.8 2.7 8.7 0.2 4.3 2 1 2 4 4 4 0 SlyX PspA_IM30 PF04012.12 EAK88567.1 - 8.4 5.9 14.9 0.78 9.3 9.9 1.8 2 0 0 2 2 2 0 PspA/IM30 family WD40 PF00400.32 EAK88568.1 - 3.2e-06 27.7 2.6 0.0026 18.6 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat PK PF00224.21 EAK88569.1 - 8.5e-136 452.4 1.5 3.5e-134 447.1 0.6 2.0 2 0 0 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 EAK88569.1 - 1.9e-29 102.3 2.1 4.9e-29 100.9 1.9 1.8 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EAK88569.1 - 0.003 16.7 0.0 0.0074 15.4 0.0 1.6 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family RNA_pol_Rbc25 PF08292.12 EAK88570.1 - 1.7e-23 83.3 1.7 4.4e-18 65.8 0.0 2.2 1 1 1 2 2 2 2 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EAK88570.1 - 0.00028 21.2 0.0 0.00051 20.4 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EAK88570.1 - 0.0026 18.0 0.0 0.01 16.2 0.0 2.0 1 1 0 1 1 1 1 S1 RNA binding domain Rab5ip PF07019.12 EAK88571.1 - 4e-12 46.6 4.8 5e-12 46.2 4.8 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF5455 PF17537.2 EAK88571.1 - 0.14 12.6 3.3 0.24 11.8 3.4 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5455) Peptidase_M16 PF00675.20 EAK88572.1 - 2.2e-29 102.4 0.4 7e-29 100.7 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EAK88572.1 - 4.7e-24 85.2 1.1 7.5e-24 84.5 0.2 1.8 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EAK88572.1 - 2e-14 54.1 3.9 2.9e-06 27.4 0.3 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain S_layer_C PF05124.12 EAK88572.1 - 0.056 13.4 0.5 0.15 12.0 0.5 1.7 1 0 0 1 1 1 0 S-layer like family, C-terminal region HIT PF01230.23 EAK88573.1 - 2.9e-25 88.9 0.0 3.6e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EAK88573.1 - 3.1e-16 59.9 0.1 4e-16 59.5 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-CCCH PF00642.24 EAK88574.1 - 1.2e-08 34.6 2.1 1.2e-08 34.6 2.1 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_2 PF13639.6 EAK88574.1 - 0.00092 19.5 8.3 0.00092 19.5 8.3 1.9 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EAK88574.1 - 0.0026 17.6 8.4 0.0026 17.6 8.4 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EAK88574.1 - 0.012 15.5 8.9 0.028 14.4 8.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Torus PF16131.5 EAK88574.1 - 0.014 16.0 0.5 0.088 13.5 0.1 2.5 2 0 0 2 2 2 0 Torus domain zf-C3HC4_3 PF13920.6 EAK88574.1 - 0.084 12.7 11.6 0.021 14.7 8.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK88574.1 - 5 7.1 9.6 15 5.5 9.6 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EAK88575.1 - 4.1e-18 64.9 0.0 8.2e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) partial_CstF PF15861.5 EAK88575.1 - 3.8e-16 58.6 2.3 5.9e-16 58.0 1.5 1.8 2 0 0 2 2 2 1 Partial cleavage stimulation factor domain CSTF2_hinge PF14327.6 EAK88575.1 - 6.7e-13 48.9 1.9 9.6e-13 48.4 0.3 2.0 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 Peptidase_C97 PF05903.14 EAK88576.1 - 1e-41 142.3 0.0 1.6e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUB PF09409.10 EAK88576.1 - 2.6e-13 49.7 0.2 6.5e-13 48.4 0.1 1.7 2 0 0 2 2 2 1 PUB domain UBA PF00627.31 EAK88576.1 - 0.0056 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain HOIP-UBA PF16678.5 EAK88576.1 - 0.026 14.5 0.2 0.049 13.6 0.2 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair SCP_3 PF17844.1 EAK88576.1 - 0.18 11.6 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial SCP ortholog HXXSHH PF07586.11 EAK88576.1 - 0.36 10.4 2.3 0.38 10.3 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) Period_C PF12114.8 EAK88576.1 - 0.42 10.2 9.4 2.8 7.5 6.0 2.3 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Peptidase_C12 PF01088.21 EAK88577.1 - 2.3e-54 184.4 0.0 3.5e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EAK88577.1 - 2.1e-16 59.6 1.1 5.1e-16 58.3 1.1 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Bacillus_HBL PF05791.11 EAK88577.1 - 0.0024 17.7 0.5 0.0047 16.8 0.5 1.5 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) DUF953 PF06110.11 EAK88577.1 - 0.023 14.3 0.0 0.089 12.4 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) DUF2951 PF11166.8 EAK88577.1 - 0.096 12.9 0.7 0.24 11.6 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) ENTH PF01417.20 EAK88578.1 - 3e-12 46.7 0.0 8.9e-09 35.5 0.0 2.8 2 1 0 2 2 2 2 ENTH domain Colicin_Pyocin PF01320.18 EAK88578.1 - 0.2 11.8 1.7 1.1 9.5 0.0 3.1 4 0 0 4 4 4 0 Colicin immunity protein / pyocin immunity protein Abhydrolase_1 PF00561.20 EAK88579.1 - 6.8e-10 39.0 0.2 5.9e-09 35.9 0.1 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EAK88579.1 - 3.4e-08 33.1 0.1 6.9e-07 28.8 0.0 2.0 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EAK88579.1 - 0.00016 21.2 0.1 0.005 16.3 0.1 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EAK88579.1 - 0.0005 20.7 0.0 0.00068 20.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EAK88579.1 - 0.018 15.0 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1749 PF08538.10 EAK88579.1 - 0.089 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) RRM_1 PF00076.22 EAK88580.1 - 5.4e-20 71.0 0.1 9.6e-20 70.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phage_lysozyme2 PF18013.1 EAK88580.1 - 0.0015 18.5 0.1 0.0023 17.9 0.1 1.3 1 0 0 1 1 1 1 Phage tail lysozyme RRM_7 PF16367.5 EAK88580.1 - 0.029 14.5 0.1 0.085 13.0 0.0 1.9 2 1 0 2 2 2 0 RNA recognition motif Actin PF00022.19 EAK88581.1 - 3.6e-89 299.2 0.0 4.9e-88 295.5 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EAK88581.1 - 0.00054 18.9 0.0 0.0033 16.3 0.0 2.0 1 1 0 1 1 1 1 MreB/Mbl protein ALP_N PF17989.1 EAK88581.1 - 0.17 12.1 0.0 0.45 10.7 0.0 1.7 1 0 0 1 1 1 0 Actin like proteins N terminal domain zf-A20 PF01754.16 EAK88582.1 - 3.5e-12 46.0 10.2 3.5e-12 46.0 10.2 2.8 4 0 0 4 4 4 1 A20-like zinc finger zf-AN1 PF01428.16 EAK88582.1 - 5.5e-09 36.0 11.4 5.5e-09 36.0 11.4 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger Ribosomal_S19e PF01090.19 EAK88583.1 - 4.3e-51 172.2 0.0 4.9e-51 172.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Mnd1 PF03962.15 EAK88584.1 - 1.7e-22 79.5 0.5 2e-22 79.2 0.5 1.1 1 0 0 1 1 1 1 Mnd1 HTH domain TrmB PF01978.19 EAK88584.1 - 0.048 13.5 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Penicillinase_R PF03965.16 EAK88584.1 - 0.068 13.5 0.0 0.073 13.4 0.0 1.0 1 0 0 1 1 1 0 Penicillinase repressor DSPc PF00782.20 EAK88585.1 - 6e-28 97.3 0.1 2.1e-27 95.6 0.1 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain UPF0113_N PF17833.1 EAK88585.1 - 0.0022 18.5 0.4 0.27 11.8 0.0 3.6 3 0 0 3 3 3 1 UPF0113 Pre-PUA domain Y_phosphatase PF00102.27 EAK88585.1 - 0.0073 15.9 0.2 0.018 14.6 0.2 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Gelsolin PF00626.22 EAK88585.1 - 0.084 12.8 1.4 1 9.3 0.0 3.4 4 0 0 4 4 4 0 Gelsolin repeat eIF_4EBP PF05456.11 EAK88585.1 - 1.1 9.2 6.1 6.1 6.8 1.8 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Sec62 PF03839.16 EAK88585.1 - 5.3 6.5 8.2 0.55 9.7 3.0 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 Peptidase_S49_N PF08496.10 EAK88585.1 - 9.8 6.2 8.9 19 5.3 6.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal ATP-synt_C PF00137.21 EAK88586.1 - 1e-29 102.7 32.4 4.8e-17 62.0 13.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C EMP24_GP25L PF01105.24 EAK88587.1 - 5.1e-19 68.9 0.4 5.9e-19 68.7 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Orf78 PF06024.12 EAK88587.1 - 0.016 15.5 1.2 0.023 15.0 1.2 1.2 1 0 0 1 1 1 0 Orf78 (ac78) UQ_con PF00179.26 EAK88588.1 - 2.2e-44 150.5 0.0 2.6e-44 150.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EAK88588.1 - 0.058 13.1 0.1 0.063 13.0 0.1 1.3 1 1 0 1 1 1 0 Prokaryotic E2 family B AdoMet_Synthase PF01941.19 EAK88588.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.0 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) DUF3584 PF12128.8 EAK88589.1 - 8.8e-06 23.6 28.4 9.2e-05 20.2 28.4 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3584) FAM184 PF15665.5 EAK88589.1 - 0.0037 17.1 27.2 0.05 13.4 24.1 2.4 1 1 1 2 2 2 2 Family with sequence similarity 184, A and B OmpH PF03938.14 EAK88589.1 - 0.15 12.4 32.0 0.038 14.3 8.4 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DNA_photolyase PF00875.18 EAK88589.1 - 0.21 11.6 1.9 1.2 9.1 0.9 2.3 1 1 1 2 2 2 0 DNA photolyase DUF1664 PF07889.12 EAK88589.1 - 0.25 11.4 14.6 0.85 9.7 5.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) T7SS_ESX_EspC PF10824.8 EAK88589.1 - 0.58 10.7 3.3 2.5 8.6 0.3 3.0 2 1 1 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm Cep57_MT_bd PF06657.13 EAK88589.1 - 0.87 10.1 12.0 0.46 11.0 0.5 3.4 2 2 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Nbl1_Borealin_N PF10444.9 EAK88589.1 - 0.88 9.3 10.1 0.83 9.3 0.3 4.3 4 2 2 6 6 6 0 Nbl1 / Borealin N terminal DUF3641 PF12345.8 EAK88589.1 - 0.97 9.5 12.5 0.5 10.4 6.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) Mst1_SARAH PF11629.8 EAK88589.1 - 1.2 9.3 12.7 0.69 10.0 1.1 3.9 3 1 1 4 4 4 0 C terminal SARAH domain of Mst1 Phage_lysis PF03245.13 EAK88589.1 - 1.6 8.9 14.3 0.051 13.7 3.2 2.7 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Phage_Mu_Gam PF07352.12 EAK88589.1 - 1.7 8.6 26.6 0.22 11.4 4.8 3.8 2 2 2 4 4 4 0 Bacteriophage Mu Gam like protein PocR PF10114.9 EAK88589.1 - 2.4 7.9 6.9 1.1 9.0 0.7 2.5 2 0 0 2 2 2 0 Sensory domain found in PocR TACC_C PF05010.14 EAK88589.1 - 2.7 7.7 29.5 1.9 8.2 19.9 2.7 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Phasin PF05597.11 EAK88589.1 - 2.7 8.0 13.9 0.11 12.5 3.5 2.9 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ApoLp-III PF07464.11 EAK88589.1 - 3.3 7.8 25.1 9.8 6.3 5.1 2.9 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) KfrA_N PF11740.8 EAK88589.1 - 4 8.1 8.9 3.3 8.4 0.6 2.6 2 1 0 2 2 2 0 Plasmid replication region DNA-binding N-term Muted PF14942.6 EAK88589.1 - 4.5 7.6 31.4 0.058 13.7 5.1 3.0 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein DUF4407 PF14362.6 EAK88589.1 - 4.6 6.5 22.4 0.43 9.9 10.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) IFT57 PF10498.9 EAK88589.1 - 6.6 5.6 32.0 2.3 7.1 14.2 2.7 1 1 3 4 4 4 0 Intra-flagellar transport protein 57 Rootletin PF15035.6 EAK88589.1 - 8.8 6.3 26.5 0.4 10.7 6.6 2.6 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion AAA PF00004.29 EAK88590.1 - 6e-94 311.4 0.0 8.9e-47 158.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAK88590.1 - 5.4e-28 96.5 6.7 3.5e-15 55.5 1.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EAK88590.1 - 7.6e-22 77.3 0.2 2.1e-21 75.9 0.2 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EAK88590.1 - 1.3e-13 51.0 0.0 8e-06 25.7 0.0 3.2 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EAK88590.1 - 6.5e-12 46.2 1.7 0.0009 19.7 0.0 4.4 3 2 0 4 4 3 2 AAA ATPase domain AAA_2 PF07724.14 EAK88590.1 - 1.1e-11 45.2 0.0 3.3e-06 27.3 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAK88590.1 - 1.2e-10 41.6 0.1 1e-05 25.6 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 EAK88590.1 - 1.3e-10 40.9 0.0 3.4e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 EAK88590.1 - 6.7e-10 39.3 0.0 9.7e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EAK88590.1 - 1.9e-08 34.7 0.6 0.037 14.3 0.1 4.4 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 EAK88590.1 - 6.1e-08 32.2 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EAK88590.1 - 2.5e-07 31.3 0.0 0.033 14.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EAK88590.1 - 6.1e-07 29.0 0.3 0.038 13.4 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EAK88590.1 - 8.2e-07 29.4 0.0 0.029 14.8 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_14 PF13173.6 EAK88590.1 - 9.8e-07 28.9 0.0 0.011 15.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EAK88590.1 - 1.3e-06 28.2 0.4 0.54 9.8 0.0 3.6 2 1 1 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EAK88590.1 - 5.9e-06 26.1 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase_2 PF01637.18 EAK88590.1 - 3.5e-05 23.8 0.0 0.57 10.0 0.0 3.2 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EAK88590.1 - 5.3e-05 23.7 0.1 0.15 12.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EAK88590.1 - 5.5e-05 23.1 0.0 0.023 14.6 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein NACHT PF05729.12 EAK88590.1 - 6e-05 23.0 0.1 0.55 10.1 0.0 3.4 2 1 0 3 3 3 2 NACHT domain ATPase PF06745.13 EAK88590.1 - 6.8e-05 22.3 0.4 2.9 7.2 0.0 3.6 4 0 0 4 4 4 1 KaiC AAA_7 PF12775.7 EAK88590.1 - 7.3e-05 22.4 0.0 0.39 10.2 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EAK88590.1 - 8.7e-05 22.8 0.0 0.38 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EAK88590.1 - 0.00011 21.9 0.6 0.14 11.9 0.0 2.9 3 1 0 3 3 2 1 AAA domain ABC_tran PF00005.27 EAK88590.1 - 0.00013 22.5 0.0 0.45 11.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter TsaE PF02367.17 EAK88590.1 - 0.00015 21.8 0.0 0.72 9.9 0.0 2.8 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EAK88590.1 - 0.00018 21.2 0.0 0.31 10.7 0.0 3.1 2 2 0 2 2 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EAK88590.1 - 0.00021 20.5 0.0 0.47 9.5 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Viral_helicase1 PF01443.18 EAK88590.1 - 0.00031 20.6 0.0 0.03 14.0 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 EAK88590.1 - 0.00042 19.6 0.0 0.97 8.6 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain Zeta_toxin PF06414.12 EAK88590.1 - 0.0013 18.1 0.0 0.95 8.7 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin DUF815 PF05673.13 EAK88590.1 - 0.0016 17.6 0.0 0.57 9.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 EAK88590.1 - 0.0021 18.2 0.0 0.44 10.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Vps4_C PF09336.10 EAK88590.1 - 0.0021 18.0 0.1 0.0085 16.1 0.0 2.1 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain PhoH PF02562.16 EAK88590.1 - 0.0028 17.1 0.3 1.9 7.9 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein DUF2075 PF09848.9 EAK88590.1 - 0.0037 16.5 0.0 0.69 9.1 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.15 EAK88590.1 - 0.0043 17.0 0.0 1.1 9.1 0.0 2.7 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_3 PF07726.11 EAK88590.1 - 0.0055 16.6 0.0 4.2 7.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EAK88590.1 - 0.0086 16.1 0.0 0.43 10.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EAK88590.1 - 0.011 16.1 0.3 6.7 7.0 0.1 3.2 3 1 0 4 4 2 0 AAA domain NTPase_1 PF03266.15 EAK88590.1 - 0.019 14.9 1.4 8 6.3 0.0 3.7 4 0 0 4 4 3 0 NTPase AAA_30 PF13604.6 EAK88590.1 - 0.025 14.3 0.1 6.2 6.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.6 EAK88590.1 - 0.025 14.7 0.2 5.8 7.0 0.0 2.6 3 0 0 3 3 2 0 Cytidylate kinase-like family KAP_NTPase PF07693.14 EAK88590.1 - 0.044 13.0 0.1 2.4 7.3 0.0 3.0 2 2 2 4 4 4 0 KAP family P-loop domain AAA_29 PF13555.6 EAK88590.1 - 0.046 13.5 0.0 5.4 6.8 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_11 PF13086.6 EAK88590.1 - 0.052 13.3 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EAK88590.1 - 0.06 13.1 0.2 8.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase SKI PF01202.22 EAK88590.1 - 0.068 13.3 0.1 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase Oxysterol_BP PF01237.18 EAK88591.1 - 2.8e-107 358.8 1.9 2.8e-107 358.8 1.9 2.1 2 1 0 2 2 2 1 Oxysterol-binding protein AP_endonuc_2 PF01261.24 EAK88592.1 - 4.6e-31 107.9 0.0 3e-30 105.2 0.0 1.9 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel Ribosomal_S21e PF01249.18 EAK88593.1 - 2.7e-33 113.9 0.0 2.9e-33 113.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e UCH PF00443.29 EAK88594.1 - 1.8e-43 148.9 0.5 2.3e-43 148.6 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK88594.1 - 5.7e-08 32.7 4.9 9.8e-06 25.4 4.9 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EAK88594.1 - 1.8e-07 30.8 0.0 7.3e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family RE_NgoPII PF09521.10 EAK88594.1 - 0.0033 16.6 0.1 0.0068 15.6 0.1 1.4 1 0 0 1 1 1 1 NgoPII restriction endonuclease Glycos_transf_1 PF00534.20 EAK88595.1 - 5.3e-29 100.9 0.0 4.2e-28 98.0 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EAK88595.1 - 3e-12 47.1 0.0 7.5e-12 45.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EAK88595.1 - 0.0005 20.1 0.0 0.00082 19.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EAK88595.1 - 0.0037 17.6 0.0 0.0082 16.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Mannosyl_trans PF05007.13 EAK88596.1 - 5.2e-54 183.8 26.4 8.4e-54 183.1 26.4 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) TRM13 PF05206.14 EAK88597.1 - 3.8e-22 79.1 11.9 1.1e-13 51.4 0.9 3.6 3 1 1 4 4 4 2 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 EAK88597.1 - 9.9e-07 28.4 3.5 9.9e-07 28.4 3.5 2.1 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein WBS_methylT PF12589.8 EAK88598.1 - 1e-20 74.3 2.2 1.7e-20 73.5 2.2 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 EAK88598.1 - 8.9e-08 32.7 0.0 1.6e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK88598.1 - 1.2e-07 32.2 0.0 2.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK88598.1 - 0.00023 21.8 0.0 0.00051 20.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK88598.1 - 0.0035 17.2 0.0 0.0045 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK88598.1 - 0.035 13.9 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 EAK88599.1 - 2e-55 188.0 0.0 3.2e-55 187.3 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88599.1 - 8e-30 104.0 0.3 2.7e-28 99.0 0.3 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK88599.1 - 1.7e-07 30.9 0.5 1.4e-05 24.6 0.0 2.7 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EAK88599.1 - 3.4e-05 22.8 0.0 8.2e-05 21.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 EAK88599.1 - 0.039 13.6 0.9 0.66 9.6 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 TypeIII_RM_meth PF12564.8 EAK88599.1 - 0.79 9.9 4.0 0.35 11.0 0.6 2.2 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit AAA_23 PF13476.6 EAK88600.1 - 2.7e-28 99.9 6.1 2.7e-28 99.9 6.1 6.0 3 3 2 5 5 4 1 AAA domain SMC_N PF02463.19 EAK88600.1 - 1.4e-11 44.3 20.7 1.4e-07 31.2 0.0 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EAK88600.1 - 4.1e-07 30.1 0.7 0.00048 20.0 0.0 4.1 4 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EAK88600.1 - 2.2e-05 25.0 0.1 9.7e-05 22.9 0.0 5.2 4 1 1 5 5 4 2 ABC transporter AAA_16 PF13191.6 EAK88600.1 - 0.00025 21.5 0.2 0.0023 18.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EAK88600.1 - 0.00052 19.7 0.0 0.0014 18.3 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EAK88600.1 - 0.0017 18.7 5.1 0.0039 17.5 0.0 3.8 3 1 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 EAK88600.1 - 0.0091 16.2 0.0 0.031 14.5 0.0 1.9 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EAK88600.1 - 0.018 14.8 102.2 0.27 10.9 45.4 4.1 1 1 2 3 3 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EAK88600.1 - 0.038 13.3 0.0 0.13 11.5 0.0 1.9 1 0 0 1 1 1 0 Zeta toxin AKNA PF12443.8 EAK88600.1 - 0.053 14.2 0.1 0.053 14.2 0.1 4.0 5 0 0 5 5 4 0 AT-hook-containing transcription factor CAF1C_H4-bd PF12265.8 EAK88601.1 - 5.4e-23 81.0 1.6 6.2e-21 74.4 0.7 2.8 2 0 0 2 2 2 2 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EAK88601.1 - 1.3e-20 73.4 8.7 8.6e-05 23.2 0.0 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat EF-hand_7 PF13499.6 EAK88602.1 - 6.4e-25 87.4 2.8 1.9e-13 50.6 0.6 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAK88602.1 - 2.9e-24 82.7 4.7 6.8e-07 28.4 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EAK88602.1 - 1.4e-20 71.4 1.1 0.0012 18.7 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EAK88602.1 - 2.6e-18 64.6 2.7 0.00018 20.9 0.0 4.3 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 EAK88602.1 - 1.2e-11 45.0 0.3 2.2e-05 24.8 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 EAK88602.1 - 4.4e-11 42.4 5.9 8.8e-05 22.3 0.4 4.3 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_4 PF12763.7 EAK88602.1 - 0.0012 18.8 3.9 0.86 9.6 0.4 3.3 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EAK88602.1 - 0.0025 18.1 0.0 1.9 8.9 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain Dockerin_1 PF00404.18 EAK88602.1 - 0.0054 16.9 0.3 1.5 9.1 0.4 3.6 3 1 1 4 4 4 1 Dockerin type I domain Caleosin PF05042.13 EAK88602.1 - 0.0074 16.2 0.8 0.91 9.4 0.0 3.3 3 1 1 4 4 4 1 Caleosin related protein Utp11 PF03998.13 EAK88603.1 - 2.1e-49 168.7 20.7 2.4e-49 168.5 20.7 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EAK88603.1 - 0.011 15.1 0.2 0.011 15.1 0.2 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Spectrin_like PF18373.1 EAK88603.1 - 2.2 8.4 7.6 0.51 10.4 2.3 2.5 2 1 1 3 3 3 0 Spectrin like domain Coq4 PF05019.13 EAK88604.1 - 6.4e-50 169.5 0.1 4e-46 157.1 0.0 2.1 2 0 0 2 2 2 2 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 zf-C2H2_4 PF13894.6 EAK88605.1 - 1.6e-06 28.4 6.9 0.0048 17.6 1.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EAK88605.1 - 8.9e-06 25.9 5.2 0.00016 21.9 1.1 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EAK88605.1 - 2.9e-05 24.3 6.5 0.034 14.6 0.7 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2HC_2 PF13913.6 EAK88605.1 - 0.001 18.9 3.6 0.011 15.6 0.2 2.6 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 EAK88605.1 - 0.0021 18.4 3.3 1.2 9.5 0.2 2.5 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) LIM PF00412.22 EAK88605.1 - 0.023 14.9 1.7 0.039 14.2 1.7 1.4 1 0 0 1 1 1 0 LIM domain Rad50_zn_hook PF04423.14 EAK88605.1 - 0.027 14.3 1.3 0.11 12.4 0.1 2.4 1 1 1 2 2 2 0 Rad50 zinc hook motif DUF629 PF04780.12 EAK88605.1 - 0.49 8.9 6.6 0.17 10.4 0.8 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF629) zf-BED PF02892.15 EAK88605.1 - 5 7.2 9.5 0.92 9.6 3.2 2.3 1 1 1 2 2 2 0 BED zinc finger Alpha-2-MRAP_C PF06401.11 EAK88607.1 - 0.0054 16.7 3.2 0.0065 16.5 3.2 1.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin RAP, C-terminal domain Prefoldin PF02996.17 EAK88607.1 - 0.015 15.2 1.9 0.052 13.5 0.5 2.2 2 0 0 2 2 2 0 Prefoldin subunit Exonuc_VII_L PF02601.15 EAK88607.1 - 0.039 13.5 0.8 0.047 13.2 0.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prominin PF05478.11 EAK88607.1 - 0.13 10.2 3.4 0.15 10.0 3.4 1.2 1 0 0 1 1 1 0 Prominin Herpes_UL6 PF01763.16 EAK88607.1 - 0.14 10.7 3.9 0.16 10.5 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF4535 PF15054.6 EAK88609.1 - 0.022 14.5 0.4 0.12 12.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) Cut12 PF11500.8 EAK88609.1 - 0.074 13.0 12.9 0.046 13.7 2.9 2.4 2 0 0 2 2 2 0 Spindle pole body formation-associated protein Mod_r PF07200.13 EAK88609.1 - 0.15 12.1 30.1 0.55 10.3 1.9 4.1 2 1 1 4 4 4 0 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.12 EAK88609.1 - 0.28 11.7 4.7 3.1 8.3 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EAK88609.1 - 3.9 7.5 11.7 3.6 7.6 0.5 3.3 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) LTXXQ PF07813.12 EAK88609.1 - 4.2 8.1 8.4 1.9 9.2 1.7 3.0 3 0 0 3 3 3 0 LTXXQ motif family protein YabA PF06156.13 EAK88609.1 - 7 7.4 20.4 15 6.3 1.7 4.2 4 0 0 4 4 4 0 Initiation control protein YabA DUF16 PF01519.16 EAK88609.1 - 9.7 6.7 17.7 0.84 10.2 0.8 3.5 2 1 1 3 3 3 0 Protein of unknown function DUF16 UPF0020 PF01170.18 EAK88610.1 - 0.16 11.6 0.0 9.9 5.8 0.0 2.3 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Patched PF02460.18 EAK88611.1 - 3e-100 336.5 0.0 7.2e-100 335.3 0.0 1.6 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EAK88611.1 - 1e-20 74.2 6.3 1e-20 74.2 6.3 2.5 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 EAK88611.1 - 0.16 9.5 9.8 0.25 9.0 9.8 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DUF4752 PF15944.5 EAK88612.1 - 0.14 12.2 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) Maf PF02545.14 EAK88613.1 - 1.3e-32 113.0 0.1 1.4e-32 112.8 0.1 1.0 1 0 0 1 1 1 1 Maf-like protein MxiM PF11441.8 EAK88613.1 - 0.015 15.5 0.9 0.068 13.5 0.1 2.3 1 1 1 2 2 2 0 Pilot protein MxiM ChpXY PF10216.9 EAK88614.1 - 0.008 15.4 0.0 0.0099 15.1 0.0 1.1 1 0 0 1 1 1 1 CO2 hydration protein (ChpXY) CopK PF11525.8 EAK88614.1 - 0.05 13.2 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Copper resistance protein K GIY-YIG PF01541.24 EAK88615.1 - 1.9e-11 44.1 0.1 1.1e-10 41.6 0.0 2.3 1 1 1 2 2 2 1 GIY-YIG catalytic domain zf-RING_2 PF13639.6 EAK88615.1 - 0.12 12.7 7.9 0.16 12.4 2.7 2.5 2 0 0 2 2 2 0 Ring finger domain DUF872 PF05915.12 EAK88616.1 - 3.4e-10 40.1 0.2 3.8e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) HXXEE PF13787.6 EAK88616.1 - 0.033 15.0 0.7 0.042 14.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function with HXXEE motif RAMP4 PF06624.12 EAK88616.1 - 0.56 10.3 9.5 0.84 9.7 7.7 2.2 2 1 0 2 2 2 0 Ribosome associated membrane protein RAMP4 GCFC PF07842.12 EAK88618.1 - 1.6e-15 57.5 6.6 1.6e-15 57.5 6.6 2.0 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EAK88618.1 - 1e-08 34.9 0.6 2.1e-08 33.9 0.6 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EAK88618.1 - 0.83 9.8 2.3 0.95 9.6 0.1 2.3 3 0 0 3 3 3 0 G-patch domain Raptor_N PF14538.6 EAK88618.1 - 0.95 9.4 3.7 2.6 8.0 0.9 2.7 2 1 0 2 2 2 0 Raptor N-terminal CASPase like domain DUF4522 PF15022.6 EAK88618.1 - 4.3 7.6 6.5 0.81 10.0 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) E1-E2_ATPase PF00122.20 EAK88619.1 - 1.3e-17 63.9 0.0 8e-17 61.3 0.0 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EAK88619.1 - 5.5e-15 56.2 0.0 3.3e-05 24.3 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase CBM64 PF18666.1 EAK88619.1 - 0.0054 16.8 0.3 1.1 9.4 0.0 2.7 2 0 0 2 2 2 2 Carbohydrate-binding module 64 Cation_ATPase PF13246.6 EAK88619.1 - 0.043 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Band_3_cyto PF07565.13 EAK88620.1 - 0.031 14.1 0.3 0.031 14.1 0.3 3.0 2 1 1 3 3 3 0 Band 3 cytoplasmic domain Lar_N PF09861.9 EAK88620.1 - 0.13 11.4 2.3 0.28 10.3 1.7 1.9 1 1 0 1 1 1 0 Lactate racemase N-terminal domain DUF3053 PF11254.8 EAK88620.1 - 2.8 7.5 9.1 0.52 9.9 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3053) Ribosomal_L23 PF00276.20 EAK88621.1 - 0.0039 17.5 2.9 0.028 14.8 1.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L23 COPIIcoated_ERV PF07970.12 EAK88621.1 - 0.015 15.2 0.4 0.018 14.9 0.4 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum vesicle transporter Solute_trans_a PF03619.16 EAK88622.1 - 9.3e-75 251.6 18.1 1.3e-74 251.1 18.1 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DEAD PF00270.29 EAK88623.1 - 3.5e-15 56.2 0.0 1e-14 54.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK88623.1 - 2.9e-08 34.0 0.3 1e-05 25.9 0.2 2.7 1 1 1 2 2 2 2 Helicase conserved C-terminal domain UQ_con PF00179.26 EAK88624.1 - 1.8e-06 27.6 2.6 1.9e-06 27.5 0.5 2.1 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EAK88624.1 - 0.016 15.1 0.5 0.12 12.3 0.5 2.3 1 1 0 1 1 1 0 UEV domain IMCp PF12314.8 EAK88626.1 - 2.5e-18 66.1 47.4 1.8e-13 50.6 21.7 3.2 1 1 2 3 3 3 3 Inner membrane complex protein Phage_holin_3_6 PF07332.11 EAK88627.1 - 0.0068 16.4 1.4 0.0082 16.2 1.4 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF202 PF02656.15 EAK88627.1 - 0.048 14.1 1.2 0.072 13.6 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) PIRT PF15099.6 EAK88627.1 - 0.15 11.7 3.4 0.29 10.7 3.4 1.5 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family PMP22_Claudin PF00822.20 EAK88627.1 - 0.16 11.9 1.9 0.23 11.3 1.9 1.2 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family CD34_antigen PF06365.12 EAK88627.1 - 0.17 11.5 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family PsbX PF06596.11 EAK88627.1 - 0.87 9.6 7.1 0.27 11.3 1.1 2.2 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) EphA2_TM PF14575.6 EAK88627.1 - 1.5 9.8 0.0 1.5 9.8 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RMI2 PF16100.5 EAK88628.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 SNF2_N PF00176.23 EAK88629.1 - 2.6e-39 135.0 0.0 7.5e-39 133.4 0.0 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK88629.1 - 6.2e-10 39.4 0.1 2.9e-09 37.2 0.1 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain F-box PF00646.33 EAK88629.1 - 0.026 14.4 3.9 6.6 6.7 0.1 3.9 3 0 0 3 3 3 0 F-box domain F-box_4 PF15966.5 EAK88629.1 - 0.03 14.2 1.3 0.1 12.5 1.3 1.9 1 0 0 1 1 1 0 F-box AAA_22 PF13401.6 EAK88629.1 - 0.042 14.1 0.0 3.2 8.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain APAF1_C PF17908.1 EAK88629.1 - 0.14 12.1 3.1 0.6 10.1 0.1 3.4 2 1 0 2 2 2 0 APAF-1 helical domain F-box-like PF12937.7 EAK88629.1 - 0.16 11.8 1.2 1.2 9.0 0.1 2.9 3 0 0 3 3 3 0 F-box-like DUF3336 PF11815.8 EAK88630.1 - 1.4e-28 99.3 2.3 1.4e-28 99.3 2.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EAK88630.1 - 4.1e-22 79.4 0.0 1.3e-21 77.8 0.0 1.7 2 0 0 2 2 2 1 Patatin-like phospholipase DUF5071 PF16804.5 EAK88630.1 - 0.41 10.9 1.8 33 4.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5071) SF-assemblin PF06705.11 EAK88632.1 - 7.7e-08 32.0 29.3 3.1e-07 30.0 20.2 2.5 2 1 0 2 2 2 2 SF-assemblin/beta giardin MINDY_DUB PF04424.13 EAK88632.1 - 0.24 11.4 3.7 2.5 8.1 0.5 2.8 3 1 0 3 3 3 0 MINDY deubiquitinase ABC_tran_CTD PF16326.5 EAK88632.1 - 0.26 11.6 0.1 0.26 11.6 0.1 4.4 3 2 2 5 5 5 0 ABC transporter C-terminal domain SATase_N PF06426.14 EAK88632.1 - 0.32 11.4 1.7 1.4 9.3 0.1 2.6 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal DUF1600 PF07667.11 EAK88635.1 - 0.0056 16.9 3.2 0.0087 16.2 3.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1600) EF-hand_7 PF13499.6 EAK88636.1 - 1.8e-19 70.0 16.5 1.4e-09 38.3 2.2 4.8 3 2 4 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.6 EAK88636.1 - 3.6e-17 61.0 10.5 4.5e-05 22.7 0.2 4.9 4 0 0 4 4 4 4 EF hand EF-hand_1 PF00036.32 EAK88636.1 - 1.7e-15 55.3 21.0 8.8e-05 21.8 0.2 5.3 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EAK88636.1 - 5.5e-15 53.9 16.2 0.0022 17.8 0.1 5.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EAK88636.1 - 2e-07 30.8 19.4 0.00034 20.4 0.4 6.1 6 1 1 7 7 7 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EAK88636.1 - 0.013 15.8 2.7 0.099 13.0 0.5 3.4 2 1 3 5 5 5 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_like PF09279.11 EAK88636.1 - 0.043 14.3 2.7 0.39 11.2 0.0 3.2 3 0 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.6 EAK88636.1 - 0.15 12.0 5.3 2.9 7.8 0.1 3.8 4 0 0 4 4 4 0 EF hand Myb_DNA-binding PF00249.31 EAK88637.1 - 9.1e-13 48.2 0.4 1.6e-12 47.4 0.4 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EAK88637.1 - 0.00029 20.7 0.2 0.00074 19.4 0.2 1.6 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EAK88637.1 - 0.027 14.7 0.2 0.06 13.6 0.2 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Pox_Ag35 PF03286.14 EAK88637.1 - 4.9 6.9 11.4 0.15 11.9 4.1 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein V-ATPase_H_C PF11698.8 EAK88638.1 - 9.7e-40 135.3 2.7 2e-39 134.3 0.6 2.4 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EAK88638.1 - 3.2e-34 118.7 0.2 4.9e-34 118.1 0.2 1.2 1 0 0 1 1 1 1 V-ATPase subunit H Arm_2 PF04826.13 EAK88638.1 - 0.0001 21.9 0.7 0.00068 19.2 0.1 2.3 2 0 0 2 2 2 1 Armadillo-like HEAT_2 PF13646.6 EAK88638.1 - 0.014 15.8 0.3 1.4 9.4 0.0 3.2 3 0 0 3 3 3 0 HEAT repeats Arm PF00514.23 EAK88638.1 - 0.053 13.6 1.2 16 5.8 0.0 3.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat EF1_GNE PF00736.19 EAK88639.1 - 1e-23 83.3 1.7 1e-23 83.3 1.7 2.1 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain Stm1_N PF09598.10 EAK88639.1 - 0.017 16.0 3.3 0.017 16.0 3.3 1.8 2 0 0 2 2 2 0 Stm1 YlbD_coat PF14071.6 EAK88639.1 - 0.026 14.8 4.5 0.049 13.9 1.2 2.2 2 0 0 2 2 2 0 Putative coat protein EF-1_beta_acid PF10587.9 EAK88639.1 - 0.069 13.6 7.3 0.069 13.6 7.3 2.6 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region Pal1 PF08316.11 EAK88639.1 - 0.076 13.8 2.9 0.13 13.0 0.9 2.0 2 0 0 2 2 2 0 Pal1 cell morphology protein NUDIX_4 PF14815.6 EAK88640.1 - 0.0082 16.1 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain MIF4G PF02854.19 EAK88641.1 - 1.1e-30 106.9 5.9 2.7e-30 105.6 5.9 1.8 1 0 0 1 1 1 1 MIF4G domain AAA_14 PF13173.6 EAK88641.1 - 0.014 15.4 0.1 0.09 12.8 0.1 2.4 1 0 0 1 1 1 0 AAA domain NDUF_B4 PF07225.12 EAK88643.1 - 0.016 15.1 0.1 0.12 12.3 0.0 2.2 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Tape_meas_lam_C PF09718.10 EAK88643.1 - 0.1 12.8 0.1 0.96 9.6 0.0 2.7 4 0 0 4 4 4 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Rad51 PF08423.11 EAK88644.1 - 4.4e-08 32.7 0.3 6.4e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Rad51 ABC_tran PF00005.27 EAK88644.1 - 0.0033 17.9 1.9 0.0033 17.9 1.9 2.2 2 1 0 2 2 2 1 ABC transporter EF-hand_7 PF13499.6 EAK88645.1 - 4.1e-15 56.0 3.3 1.6e-10 41.3 0.8 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAK88645.1 - 1e-13 49.8 0.4 1e-05 24.7 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 EAK88645.1 - 1.6e-11 43.2 1.8 1.7e-05 24.1 0.5 2.7 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.6 EAK88645.1 - 4.7e-09 35.5 1.4 0.00023 20.8 0.1 2.6 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EAK88645.1 - 1.9e-08 34.0 0.6 0.00027 20.7 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EAK88645.1 - 8.2e-06 26.1 0.2 1.2e-05 25.6 0.2 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region LXG PF04740.12 EAK88645.1 - 0.00063 19.5 0.1 0.001 18.8 0.1 1.3 1 1 0 1 1 1 1 LXG domain of WXG superfamily Dockerin_1 PF00404.18 EAK88645.1 - 0.0071 16.5 0.0 0.09 13.0 0.0 2.1 2 0 0 2 2 2 1 Dockerin type I domain Lyase_catalyt PF09093.11 EAK88645.1 - 0.042 13.0 0.1 0.048 12.8 0.1 1.0 1 0 0 1 1 1 0 Lyase, catalytic Haemagg_act PF05860.13 EAK88645.1 - 0.3 11.0 7.7 1.4 8.8 4.6 2.4 1 1 1 2 2 2 0 haemagglutination activity domain ABC_tran PF00005.27 EAK88646.1 - 1.3e-18 67.8 29.3 7.5e-12 45.9 0.0 4.4 3 1 0 3 3 3 2 ABC transporter AAA_29 PF13555.6 EAK88646.1 - 1.3e-06 28.0 1.0 0.017 14.9 0.0 3.4 3 0 0 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EAK88646.1 - 0.00013 22.0 2.2 0.26 11.4 0.2 3.5 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EAK88646.1 - 0.0016 18.8 0.0 0.58 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain ABC_membrane PF00664.23 EAK88646.1 - 0.0021 17.8 5.4 0.0021 17.8 5.4 4.0 3 1 0 3 3 3 2 ABC transporter transmembrane region Roc PF08477.13 EAK88646.1 - 0.0023 18.1 0.9 0.73 10.1 0.0 3.5 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EAK88646.1 - 0.0029 17.5 0.1 1 9.3 0.0 2.8 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EAK88646.1 - 0.0038 17.5 0.2 6.1 7.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EAK88646.1 - 0.0075 15.5 0.1 1.8 7.7 0.0 2.7 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 EAK88646.1 - 0.027 14.9 1.3 37 4.8 0.0 4.5 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EAK88646.1 - 0.033 14.1 0.1 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 NACHT domain DUF3593 PF12159.8 EAK88646.1 - 0.039 14.0 0.2 0.14 12.2 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3593) AAA_33 PF13671.6 EAK88646.1 - 0.043 14.0 0.0 0.44 10.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EAK88646.1 - 0.045 14.3 11.3 3.7 8.1 0.1 5.0 4 0 0 4 4 4 0 AAA domain FtsK_SpoIIIE PF01580.18 EAK88646.1 - 0.054 12.9 0.0 6.2 6.1 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family TsaE PF02367.17 EAK88646.1 - 0.07 13.1 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynamin_N PF00350.23 EAK88646.1 - 0.16 12.0 0.0 0.16 12.0 0.0 4.8 4 1 0 4 4 4 0 Dynamin family FH2 PF02181.23 EAK88647.1 - 5e-17 62.1 14.7 5e-17 62.1 14.7 2.4 3 0 0 3 3 3 1 Formin Homology 2 Domain zf-B_box PF00643.24 EAK88648.1 - 8.5e-10 38.6 14.9 8.4e-08 32.2 1.6 3.3 4 0 0 4 4 4 2 B-box zinc finger PARP PF00644.20 EAK88648.1 - 0.12 11.9 2.3 0.28 10.7 1.4 2.3 2 1 0 2 2 2 0 Poly(ADP-ribose) polymerase catalytic domain SR-25 PF10500.9 EAK88651.1 - 0.0013 18.4 10.3 0.0015 18.2 8.4 1.9 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Dicty_REP PF05086.12 EAK88651.1 - 0.0025 15.9 10.7 0.0036 15.4 10.7 1.3 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein SOG2 PF10428.9 EAK88651.1 - 0.0071 15.6 20.6 0.009 15.3 20.6 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein NAM-associated PF14303.6 EAK88651.1 - 0.031 15.0 9.5 0.077 13.7 9.5 1.6 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain SPX PF03105.19 EAK88651.1 - 0.031 14.2 14.1 0.046 13.6 14.1 1.3 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 EAK88651.1 - 0.041 12.4 12.8 0.054 12.1 12.8 1.2 1 0 0 1 1 1 0 Macoilin family FSA_C PF10479.9 EAK88651.1 - 0.048 11.8 11.5 0.069 11.3 11.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FAM76 PF16046.5 EAK88651.1 - 0.18 11.2 9.4 0.27 10.6 9.4 1.2 1 0 0 1 1 1 0 FAM76 protein Otopetrin PF03189.13 EAK88651.1 - 1.3 7.8 7.3 1.7 7.4 7.3 1.3 1 0 0 1 1 1 0 Otopetrin Peptidase_S64 PF08192.11 EAK88651.1 - 1.3 7.4 15.0 1.7 7.0 15.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 NST1 PF13945.6 EAK88651.1 - 1.6 8.8 13.0 3.6 7.6 13.0 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF508 PF04370.12 EAK88651.1 - 1.9 8.3 9.5 2.5 7.8 8.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF508) HNF-1_N PF04814.13 EAK88651.1 - 5.5 7.6 18.2 4 8.0 16.3 1.7 1 1 1 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus bZIP_1 PF00170.21 EAK88652.1 - 0.033 14.3 1.0 0.033 14.3 1.0 2.3 2 0 0 2 2 2 0 bZIP transcription factor HALZ PF02183.18 EAK88652.1 - 0.055 13.7 0.5 0.25 11.6 0.5 2.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper GARP PF16731.5 EAK88652.1 - 0.073 12.8 0.6 0.2 11.3 0.1 1.9 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Laminin_II PF06009.12 EAK88652.1 - 0.14 12.2 2.9 0.34 10.9 2.9 1.6 1 0 0 1 1 1 0 Laminin Domain II zf-C4H2 PF10146.9 EAK88652.1 - 0.99 9.7 7.3 0.13 12.6 1.2 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein NRBF2 PF08961.10 EAK88652.1 - 4.6 6.8 7.8 0.74 9.4 3.6 1.9 2 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Sedlin_N PF04628.13 EAK88653.1 - 2.9e-17 63.0 0.0 3.9e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Haem_degrading PF03928.14 EAK88653.1 - 0.16 12.0 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Haem-degrading Tim54 PF11711.8 EAK88655.1 - 0.016 14.0 17.9 0.0054 15.6 12.4 2.6 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 TFIIF_alpha PF05793.12 EAK88655.1 - 0.51 8.9 36.0 1.6 7.2 36.0 1.8 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GAGA_bind PF06217.12 EAK88655.1 - 0.68 10.2 8.0 1.8 8.8 8.0 1.7 1 0 0 1 1 1 0 GAGA binding protein-like family Zip PF02535.22 EAK88655.1 - 1.4 8.1 9.0 2.8 7.1 9.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 EAK88655.1 - 1.9 8.9 14.5 4.6 7.7 14.5 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Connexin PF00029.19 EAK88655.1 - 3.2 7.5 15.1 3.5 7.3 12.9 2.2 2 0 0 2 2 2 0 Connexin Coilin_N PF15862.5 EAK88655.1 - 7.3 6.4 20.9 31 4.3 20.9 2.1 1 0 0 1 1 1 0 Coilin N-terminus SNF2_N PF00176.23 EAK88656.1 - 1e-66 225.1 0.6 1e-66 225.1 0.6 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK88656.1 - 2.7e-20 72.8 0.0 1.8e-19 70.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK88656.1 - 1.6e-09 38.0 0.0 1.6e-09 38.0 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EAK88656.1 - 0.00014 21.7 0.0 0.001 18.9 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase YlbE PF14003.6 EAK88656.1 - 0.0089 16.5 0.3 0.0089 16.5 0.3 2.4 2 0 0 2 2 2 1 YlbE-like protein DUF3467 PF11950.8 EAK88657.1 - 0.0046 17.1 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3467) FRB_dom PF08771.11 EAK88659.1 - 0.14 12.6 2.9 5.9 7.4 0.1 2.6 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain DUF2381 PF09544.10 EAK88659.1 - 0.18 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) GST_C_3 PF14497.6 EAK88660.1 - 6e-07 29.6 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EAK88660.1 - 0.0049 17.1 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Fe_hyd_lg_C PF02906.14 EAK88662.1 - 0.017 14.8 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Bromodomain PF00439.25 EAK88663.1 - 0.00027 20.9 0.3 0.0013 18.8 0.0 2.2 3 0 0 3 3 3 1 Bromodomain MRP-S31 PF15433.6 EAK88663.1 - 0.0087 15.8 1.3 0.0087 15.8 1.3 2.0 3 0 0 3 3 3 1 Mitochondrial 28S ribosomal protein S31 F-box-like PF12937.7 EAK88665.1 - 2.8e-05 23.9 1.1 0.00051 19.9 0.1 2.7 2 0 0 2 2 2 1 F-box-like Chorein_N PF12624.7 EAK88667.1 - 0.00012 22.2 1.0 0.00012 22.2 1.0 4.0 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 ETRAMP PF09716.10 EAK88669.1 - 0.039 14.0 2.9 4.5 7.4 1.8 3.4 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF382 PF04037.13 EAK88670.1 - 4.6e-53 178.7 0.4 4.6e-53 178.7 0.4 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 EAK88670.1 - 1.6e-19 69.5 6.1 3.1e-19 68.6 6.1 1.5 1 0 0 1 1 1 1 PSP PrsW-protease PF13367.6 EAK88671.1 - 2e-12 47.0 5.2 1.5e-11 44.1 5.2 2.3 1 1 0 1 1 1 1 PrsW family intramembrane metalloprotease ERGIC_N PF13850.6 EAK88671.1 - 4 7.9 7.4 13 6.3 0.4 3.2 2 1 1 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Dus PF01207.17 EAK88672.1 - 3.4e-39 134.8 0.0 2.1e-28 99.3 0.0 3.9 3 1 0 3 3 3 3 Dihydrouridine synthase (Dus) Nsp1_C PF05064.13 EAK88673.1 - 6.2e-13 48.6 5.2 2.5e-11 43.4 4.3 2.5 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EAK88673.1 - 0.013 16.3 33.4 0.013 16.3 33.4 9.8 2 1 5 7 7 6 0 Nucleoporin FG repeat region Filament PF00038.21 EAK88673.1 - 0.029 13.9 10.7 0.17 11.4 0.5 2.2 2 0 0 2 2 2 0 Intermediate filament protein LOH1CR12 PF10158.9 EAK88673.1 - 0.086 12.9 3.1 7 6.7 0.4 2.3 2 0 0 2 2 2 0 Tumour suppressor protein DUF1664 PF07889.12 EAK88673.1 - 0.34 10.9 7.2 1.3 9.1 3.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) T2SSC PF11356.8 EAK88673.1 - 1.7 8.6 16.8 1.5 8.7 7.8 4.2 2 1 1 3 3 3 0 Type II secretion system protein C DUF724 PF05266.14 EAK88673.1 - 1.7 8.4 10.2 0.69 9.7 4.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF4175 PF13779.6 EAK88673.1 - 2.3 6.0 6.4 3.3 5.5 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Fez1 PF06818.15 EAK88673.1 - 3.9 7.9 9.1 2.8 8.3 7.4 1.6 1 1 0 1 1 1 0 Fez1 APG6_N PF17675.1 EAK88673.1 - 6.2 7.4 12.5 13 6.4 8.0 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF489 PF04356.12 EAK88673.1 - 6.5 6.7 7.8 1.7 8.6 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF489) zf-HC5HC2H_2 PF13832.6 EAK88674.1 - 1.2e-15 57.6 16.8 4.4e-10 39.7 6.4 5.9 6 0 0 6 6 6 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EAK88674.1 - 1.6e-12 47.5 14.7 3.5e-09 36.8 2.2 6.3 6 0 0 6 6 6 3 PHD-like zinc-binding domain PHD PF00628.29 EAK88674.1 - 2.9e-06 27.1 21.5 6.7e-05 22.7 2.0 7.8 8 0 0 8 8 8 3 PHD-finger Apt1 PF10351.9 EAK88676.1 - 0.00022 20.3 8.1 0.00024 20.1 8.1 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain Neur_chan_memb PF02932.16 EAK88676.1 - 0.062 13.4 0.5 0.073 13.1 0.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 EAK88676.1 - 0.18 10.5 3.7 0.24 10.0 3.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EAK88676.1 - 0.36 9.3 12.8 0.54 8.8 12.8 1.3 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 EAK88676.1 - 0.81 8.0 6.1 1 7.6 6.1 1.1 1 0 0 1 1 1 0 Menin GREB1 PF15782.5 EAK88676.1 - 1.3 6.1 8.7 1.6 5.8 8.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 EAK88676.1 - 3 6.6 5.4 5 5.8 5.4 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter AP2 PF00847.20 EAK88677.1 - 2.3e-12 46.9 2.6 5.2e-12 45.8 2.6 1.6 1 0 0 1 1 1 1 AP2 domain Tweety PF04906.13 EAK88677.1 - 3.9 6.0 5.7 8.5 4.9 5.7 1.5 1 0 0 1 1 1 0 Tweety HTH_43 PF09904.9 EAK88678.1 - 0.0024 17.8 0.0 0.0064 16.4 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix Baculo_PEP_C PF04513.12 EAK88679.1 - 0.003 17.6 1.8 0.003 17.6 1.8 1.8 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus SF-assemblin PF06705.11 EAK88679.1 - 0.0086 15.5 6.0 0.018 14.4 6.0 1.4 1 0 0 1 1 1 1 SF-assemblin/beta giardin Apolipoprotein PF01442.18 EAK88679.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF5617 PF18493.1 EAK88679.1 - 0.031 14.4 1.8 0.63 10.2 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) DUF4795 PF16043.5 EAK88679.1 - 0.042 13.4 1.7 0.082 12.5 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF1664 PF07889.12 EAK88679.1 - 0.082 13.0 1.4 0.23 11.5 1.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 EAK88679.1 - 0.1 12.5 4.7 0.35 10.8 4.7 1.9 1 1 0 1 1 1 0 Prefoldin subunit CHIP_TPR_N PF18391.1 EAK88679.1 - 0.32 11.8 4.2 0.28 12.0 1.4 2.3 1 1 1 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain Pex19 PF04614.12 EAK88679.1 - 0.8 9.4 3.4 2.8 7.6 0.6 2.1 2 0 0 2 2 2 0 Pex19 protein family Telomerase_RBD PF12009.8 EAK88680.1 - 1.9e-21 76.6 6.7 1.9e-21 76.6 6.7 3.1 2 1 1 3 3 3 1 Telomerase ribonucleoprotein complex - RNA binding domain SR-25 PF10500.9 EAK88680.1 - 0.017 14.7 19.9 0.06 12.9 19.9 1.9 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SDA1 PF05285.12 EAK88681.1 - 1.7e-34 119.8 28.4 1.7e-34 119.8 28.4 2.4 2 0 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EAK88681.1 - 9.8e-13 48.2 0.2 6.9e-12 45.5 0.1 2.7 2 0 0 2 2 2 1 NUC130/3NT domain SapB_1 PF05184.15 EAK88681.1 - 0.056 13.5 0.0 24 5.1 0.0 3.1 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF3464 PF11947.8 EAK88681.1 - 3.7 7.3 6.7 1.1 9.0 0.2 3.0 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 DUF4288 PF14119.6 EAK88681.1 - 4.3 7.8 7.6 0.27 11.7 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) FAM76 PF16046.5 EAK88683.1 - 2e-32 112.8 40.6 2.8e-32 112.3 40.6 1.2 1 0 0 1 1 1 1 FAM76 protein Peptidase_S76 PF13611.6 EAK88683.1 - 0.011 16.0 2.3 0.013 15.8 0.3 2.1 2 0 0 2 2 2 0 Serine peptidase of plant viral polyprotein, P1 KELK PF15796.5 EAK88683.1 - 0.033 14.6 5.8 0.033 14.6 5.8 3.2 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HAUS-augmin3 PF14932.6 EAK88683.1 - 0.8 9.2 20.2 0.091 12.3 3.3 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 RMI1_N PF08585.12 EAK88684.1 - 4.8e-08 33.0 1.1 4.8e-08 33.0 1.1 3.2 2 2 0 2 2 2 1 RecQ mediated genome instability protein ZYG-11_interact PF05884.12 EAK88684.1 - 0.15 11.4 0.5 0.28 10.6 0.5 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 ACR_tran PF00873.19 EAK88684.1 - 0.38 8.4 3.3 0.49 8.0 3.3 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family SWIRM-assoc_1 PF16495.5 EAK88686.1 - 0.052 13.5 2.7 0.32 11.0 2.7 2.5 1 0 0 1 1 1 0 SWIRM-associated region 1 TPR_1 PF00515.28 EAK88687.1 - 2.4e-14 52.5 0.2 4.7e-05 23.0 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EAK88687.1 - 1.8e-12 46.4 0.9 0.0035 17.3 0.0 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EAK88687.1 - 2.7e-08 34.2 1.6 0.00026 21.4 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EAK88687.1 - 5.8e-08 32.3 0.0 0.00035 20.2 0.0 3.0 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.6 EAK88687.1 - 9.8e-07 29.3 5.9 0.00011 22.8 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EAK88687.1 - 4e-06 26.6 1.6 1.2 9.6 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EAK88687.1 - 8.9e-06 25.7 0.5 0.31 11.5 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EAK88687.1 - 0.0013 19.0 2.4 0.061 13.6 0.1 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK88687.1 - 0.0073 16.5 0.3 0.0073 16.5 0.3 2.6 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EAK88687.1 - 0.0083 16.3 0.1 0.027 14.6 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EAK88687.1 - 0.057 13.5 2.4 8.7 6.6 0.0 4.7 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EAK88687.1 - 0.17 12.8 8.6 0.18 12.7 0.5 4.0 3 1 2 5 5 3 0 Tetratricopeptide repeat FH2 PF02181.23 EAK88688.1 - 0.0037 16.4 2.5 0.0055 15.9 2.5 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain Phage_int_SAM_6 PF18644.1 EAK88688.1 - 0.0092 16.0 0.2 0.019 15.0 0.2 1.6 1 0 0 1 1 1 1 Phage integrase SAM-like domain COG2 PF06148.11 EAK88688.1 - 0.035 14.2 3.5 0.049 13.7 1.5 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YojJ PF10372.9 EAK88688.1 - 0.17 12.0 1.3 0.36 10.9 0.3 2.0 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Spc7 PF08317.11 EAK88688.1 - 0.32 9.8 8.7 0.52 9.1 8.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Microvir_H PF04687.12 EAK88688.1 - 0.66 9.3 3.5 0.69 9.2 2.0 1.7 2 0 0 2 2 2 0 Microvirus H protein (pilot protein) KxDL PF10241.9 EAK88688.1 - 0.88 9.9 5.1 0.81 10.0 1.3 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF615 PF04751.14 EAK88688.1 - 1.6 8.7 9.8 1.9 8.4 8.5 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF615) SlyX PF04102.12 EAK88688.1 - 1.9 9.2 8.7 11 6.7 0.3 2.4 2 0 0 2 2 2 0 SlyX Pan3_PK PF18101.1 EAK88689.1 - 4e-47 159.6 0.1 6.3e-47 159.0 0.1 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EAK88689.1 - 5.5e-05 22.7 0.0 0.00014 21.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain HSP70 PF00012.20 EAK88690.1 - 7.2e-56 189.6 1.1 4.4e-45 154.0 0.8 3.0 2 1 0 2 2 2 2 Hsp70 protein Mucin PF01456.17 EAK88691.1 - 0.0043 17.1 27.2 0.011 15.7 27.2 1.7 1 0 0 1 1 1 1 Mucin-like glycoprotein MGC-24 PF05283.11 EAK88691.1 - 7.4 7.0 22.2 0.28 11.6 15.1 2.4 3 0 0 3 3 3 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PGM_PMM_III PF02880.16 EAK88693.1 - 9.7e-28 96.7 0.0 1.9e-27 95.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 EAK88693.1 - 7.5e-26 90.5 0.0 1.5e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EAK88693.1 - 6e-13 49.3 0.0 2.9e-12 47.1 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EAK88693.1 - 3.3e-06 27.2 0.0 8.2e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EAK88694.1 - 1.3e-27 96.2 0.0 2.7e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 EAK88694.1 - 9.3e-26 90.2 0.0 1.4e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EAK88694.1 - 3.8e-12 46.7 0.0 1.1e-11 45.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EAK88694.1 - 7.6e-06 26.0 0.0 1.8e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain LSM14 PF12701.7 EAK88695.1 - 1.1e-20 73.5 0.0 2.1e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EAK88695.1 - 2.8e-10 40.2 0.0 9.1e-10 38.5 0.0 1.9 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 EAK88695.1 - 7.6e-06 26.8 8.3 7.6e-06 26.8 8.3 2.4 3 1 0 3 3 3 1 FDF domain LSM PF01423.22 EAK88695.1 - 9.7e-06 25.2 0.0 1.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 LSM domain DUF4403 PF14356.6 EAK88695.1 - 0.044 12.4 0.0 0.071 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) PGI PF00342.19 EAK88696.1 - 1.8e-171 571.0 0.0 2.3e-171 570.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase RabGAP-TBC PF00566.18 EAK88698.1 - 2.2e-38 132.1 4.0 2.2e-38 132.1 4.0 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF4867 PF16161.5 EAK88698.1 - 0.071 12.6 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4867) Fib_alpha PF08702.10 EAK88699.1 - 0.2 11.8 6.9 0.049 13.8 2.5 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family UFD1 PF03152.14 EAK88700.1 - 7e-26 90.7 0.5 7e-26 90.7 0.5 1.9 2 0 0 2 2 2 1 Ubiquitin fusion degradation protein UFD1 DEC-1_N PF04625.13 EAK88703.1 - 5.7 5.8 16.2 2.6 7.0 2.5 3.0 3 0 0 3 3 3 0 DEC-1 protein, N-terminal region TSP_1 PF00090.19 EAK88706.1 - 2.6e-30 104.4 50.5 7.7e-11 42.0 5.3 4.5 4 0 0 4 4 4 4 Thrombospondin type 1 domain Kringle PF00051.18 EAK88706.1 - 1.1e-09 38.4 0.3 5.1e-09 36.3 0.3 2.2 1 0 0 1 1 1 1 Kringle domain HMG_box PF00505.19 EAK88707.1 - 4.4e-15 55.9 4.7 4.4e-15 55.9 4.7 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EAK88707.1 - 1.8e-09 38.0 4.9 3e-09 37.3 4.9 1.4 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 EAK88707.1 - 0.0027 17.7 0.2 0.0047 16.9 0.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box 5 Las1 PF04031.13 EAK88709.1 - 0.036 14.2 0.0 0.044 13.9 0.0 1.1 1 0 0 1 1 1 0 Las1-like Serpulina_VSP PF05540.11 EAK88711.1 - 0.043 12.9 0.2 0.067 12.2 0.2 1.3 1 0 0 1 1 1 0 Serpulina hyodysenteriae variable surface protein POR PF01558.18 EAK88711.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Mur_ligase_M PF08245.12 EAK88711.1 - 0.14 12.2 0.6 0.4 10.7 0.2 2.0 1 1 0 1 1 1 0 Mur ligase middle domain Vps36_ESCRT-II PF11605.8 EAK88712.1 - 0.012 15.7 0.1 0.02 15.0 0.1 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 AAA PF00004.29 EAK88713.1 - 2.5e-52 176.8 0.1 2.7e-39 134.6 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EAK88713.1 - 3.2e-10 40.7 0.2 0.00057 20.3 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EAK88713.1 - 1.4e-09 38.4 2.5 0.0013 19.0 0.2 4.8 3 2 1 4 4 3 1 AAA domain AAA_lid_3 PF17862.1 EAK88713.1 - 3.9e-09 36.2 0.0 9.3e-09 35.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EAK88713.1 - 7.7e-09 35.7 0.0 0.00038 20.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EAK88713.1 - 3.9e-07 29.6 0.0 0.02 14.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 EAK88713.1 - 1.2e-06 28.9 0.0 0.069 13.5 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 EAK88713.1 - 1.3e-06 28.4 0.2 0.045 13.8 0.0 2.8 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 EAK88713.1 - 1e-05 25.7 0.0 7.3e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EAK88713.1 - 1.9e-05 24.5 0.1 0.095 12.4 0.0 2.8 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_33 PF13671.6 EAK88713.1 - 2.1e-05 24.7 0.0 0.0013 18.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EAK88713.1 - 2.9e-05 24.0 3.4 0.14 12.1 0.0 3.7 4 1 1 5 5 4 2 NACHT domain Mg_chelatase PF01078.21 EAK88713.1 - 4.3e-05 23.0 0.1 0.0044 16.4 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EAK88713.1 - 5e-05 22.9 0.6 0.12 11.9 0.0 2.9 3 0 0 3 3 3 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EAK88713.1 - 6.1e-05 22.8 0.0 0.14 11.8 0.0 3.0 3 0 0 3 3 3 2 IstB-like ATP binding protein ATPase PF06745.13 EAK88713.1 - 6.8e-05 22.3 0.1 0.17 11.2 0.0 2.6 2 0 0 2 2 2 2 KaiC AAA_14 PF13173.6 EAK88713.1 - 6.8e-05 22.9 0.0 0.17 12.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EAK88713.1 - 8.1e-05 22.4 0.1 0.039 13.7 0.0 2.9 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 EAK88713.1 - 0.00015 21.0 0.0 0.19 10.9 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain ABC_tran PF00005.27 EAK88713.1 - 0.0002 21.9 0.7 0.028 14.9 0.1 2.8 2 0 0 2 2 2 1 ABC transporter DAP3 PF10236.9 EAK88713.1 - 0.00023 20.4 0.2 0.13 11.4 0.1 2.9 3 0 0 3 3 3 1 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 EAK88713.1 - 0.00028 20.5 0.1 0.44 10.1 0.0 2.8 2 1 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EAK88713.1 - 0.0003 21.3 0.0 0.19 12.3 0.0 3.2 2 1 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EAK88713.1 - 0.00059 19.6 0.2 1.4 8.6 0.2 2.6 2 1 0 2 2 2 2 AAA domain TniB PF05621.11 EAK88713.1 - 0.0021 17.5 0.2 2.4 7.5 0.0 3.0 2 1 1 3 3 3 1 Bacterial TniB protein AAA_30 PF13604.6 EAK88713.1 - 0.0023 17.7 0.1 0.035 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EAK88713.1 - 0.0026 17.3 0.2 1.1 8.7 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_28 PF13521.6 EAK88713.1 - 0.0049 17.1 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EAK88713.1 - 0.0057 15.9 0.0 0.28 10.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Torsin PF06309.11 EAK88713.1 - 0.0071 16.5 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 1 Torsin AAA_3 PF07726.11 EAK88713.1 - 0.0092 15.8 0.0 0.061 13.2 0.0 2.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EAK88713.1 - 0.014 15.4 0.1 0.21 11.6 0.0 2.7 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EAK88713.1 - 0.017 15.5 0.1 0.18 12.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain Parvo_NS1 PF01057.17 EAK88713.1 - 0.018 14.1 0.1 0.47 9.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EAK88713.1 - 0.019 14.8 0.0 0.055 13.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain Rad17 PF03215.15 EAK88713.1 - 0.025 14.5 0.0 1.8 8.5 0.0 3.1 3 0 0 3 3 3 0 Rad17 P-loop domain ATPase_2 PF01637.18 EAK88713.1 - 0.026 14.4 1.1 10 6.0 0.0 3.3 3 1 1 4 4 3 0 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 EAK88713.1 - 0.04 14.0 0.0 9.5 6.3 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain DUF815 PF05673.13 EAK88713.1 - 0.054 12.6 0.1 0.34 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 EAK88713.1 - 0.06 13.1 0.3 2.2 8.1 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain DNA_pol3_delta2 PF13177.6 EAK88713.1 - 0.083 12.7 0.1 5.3 6.8 0.0 3.1 3 1 0 4 4 3 0 DNA polymerase III, delta subunit KTI12 PF08433.10 EAK88713.1 - 0.14 11.6 0.1 0.8 9.1 0.0 2.3 3 0 0 3 3 2 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 EAK88713.1 - 0.14 11.4 0.1 15 4.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Ribosomal_S9 PF00380.19 EAK88714.1 - 1.3e-28 99.9 0.0 1.5e-28 99.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF630 PF04783.12 EAK88714.1 - 0.048 13.8 0.2 10 6.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF630) zf-RING_2 PF13639.6 EAK88716.1 - 6.2e-06 26.4 10.6 1.7e-05 25.0 10.6 1.8 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EAK88716.1 - 0.00089 19.4 6.2 0.0024 18.0 6.2 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 EAK88716.1 - 0.001 19.3 8.7 0.0032 17.7 8.7 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EAK88716.1 - 0.0035 17.4 2.9 0.0089 16.1 2.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Vac14_Fab1_bd PF12755.7 EAK88716.1 - 0.011 16.3 0.3 0.24 12.0 0.0 3.3 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region RINGv PF12906.7 EAK88716.1 - 0.015 15.4 8.1 0.033 14.3 8.1 1.7 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 EAK88716.1 - 0.027 14.1 6.2 0.057 13.1 6.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_9 PF13901.6 EAK88716.1 - 0.051 13.5 4.4 0.1 12.6 2.5 2.6 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon zf-RING-like PF08746.11 EAK88716.1 - 0.076 13.3 9.5 0.2 12.0 9.5 1.8 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.25 EAK88716.1 - 0.21 11.5 11.3 0.73 9.8 11.3 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK88716.1 - 0.64 9.9 9.2 1.6 8.7 9.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) KH_1 PF00013.29 EAK88717.1 - 0.00033 20.4 1.8 0.00035 20.3 0.2 1.9 2 0 0 2 2 2 1 KH domain zf-C3HC PF07967.13 EAK88718.1 - 0.0077 16.3 0.2 0.011 15.7 0.2 1.2 1 0 0 1 1 1 1 C3HC zinc finger-like Ku_N PF03731.15 EAK88718.1 - 0.027 14.2 0.0 0.027 14.2 0.0 1.1 1 0 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain Ribosomal_L17 PF01196.19 EAK88718.1 - 0.16 12.9 0.4 0.25 12.3 0.4 1.3 1 0 0 1 1 1 0 Ribosomal protein L17 WD40 PF00400.32 EAK88719.1 - 1.2e-27 95.6 32.0 3.5e-06 27.6 0.5 12.8 13 1 0 13 13 13 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88719.1 - 2.9e-18 66.0 0.5 0.0036 17.6 0.0 9.2 5 3 5 10 10 10 4 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EAK88719.1 - 6.1e-07 29.7 3.6 1.4e-06 28.5 3.6 1.7 1 1 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EAK88719.1 - 7.7e-05 21.8 0.1 2 7.3 0.0 4.1 2 2 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 EAK88719.1 - 0.01 15.2 0.2 1.4 8.1 0.0 3.9 5 0 0 5 5 5 1 Lactonase, 7-bladed beta-propeller DUF1513 PF07433.11 EAK88719.1 - 0.051 12.7 0.1 13 4.7 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) Prefoldin_2 PF01920.20 EAK88720.1 - 0.19 11.7 0.2 0.19 11.7 0.2 6.3 6 1 2 8 8 8 0 Prefoldin subunit DUF1845 PF08900.11 EAK88720.1 - 0.57 9.9 4.1 4.1 7.1 0.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1845) Fmp27_SW PF10305.9 EAK88720.1 - 1.4 9.6 4.5 2.6 8.8 0.1 3.3 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain ER_lumen_recept PF00810.18 EAK88721.1 - 3.3e-32 112.3 7.3 3.3e-32 112.3 7.3 2.3 3 0 0 3 3 3 1 ER lumen protein retaining receptor PsbH PF00737.20 EAK88721.1 - 0.029 14.1 0.5 0.097 12.4 0.0 2.1 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein Mntp PF02659.15 EAK88721.1 - 0.039 13.7 1.4 0.087 12.6 1.4 1.6 1 0 0 1 1 1 0 Putative manganese efflux pump BPL_LplA_LipB PF03099.19 EAK88722.1 - 1e-06 28.7 0.0 2e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Peptidase_M16_C PF05193.21 EAK88724.1 - 1.8e-12 47.7 0.1 6.1e-12 45.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK88724.1 - 0.0079 16.2 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Sec63 PF02889.16 EAK88725.1 - 4e-73 245.7 16.2 1.1e-38 132.9 1.9 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EAK88725.1 - 3.9e-48 163.5 0.0 7.1e-24 84.5 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EAK88725.1 - 6.4e-20 71.8 6.7 4.1e-11 43.2 0.0 3.4 3 1 1 4 4 4 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EAK88725.1 - 1.5e-14 54.3 3.1 3.8e-05 24.0 0.0 4.7 2 2 2 4 4 4 2 Helicase conserved C-terminal domain PhoH PF02562.16 EAK88725.1 - 0.0022 17.5 0.0 1.1 8.6 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein T2SSE PF00437.20 EAK88725.1 - 0.0044 16.1 0.0 0.7 8.9 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_19 PF13245.6 EAK88725.1 - 0.026 14.9 0.0 1.2 9.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EAK88725.1 - 0.1 11.9 0.0 8.7 5.7 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI dCMP_cyt_deam_1 PF00383.23 EAK88726.1 - 5.6e-28 96.8 2.8 8.8e-28 96.2 2.8 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EAK88726.1 - 1.4e-18 67.0 0.7 2.5e-18 66.2 0.7 1.5 1 0 0 1 1 1 1 MafB19-like deaminase DLP_helical PF18709.1 EAK88726.1 - 0.049 12.8 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Dynamin-like helical domain SNAD4 PF18750.1 EAK88726.1 - 0.37 10.9 2.3 0.89 9.7 2.3 1.6 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 THUMP PF02926.17 EAK88727.1 - 0.00011 22.3 0.0 0.00055 20.1 0.0 2.4 1 1 0 1 1 1 1 THUMP domain SYF2 PF08231.12 EAK88728.1 - 4.9e-11 43.3 19.0 2e-10 41.3 19.0 2.0 1 1 0 1 1 1 1 SYF2 splicing factor DFRP_C PF16543.5 EAK88729.1 - 4.2e-20 72.0 1.8 4.2e-20 72.0 1.8 3.4 3 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Ndc1_Nup PF09531.10 EAK88729.1 - 4.2 5.9 7.9 6.2 5.4 7.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sec16 PF12932.7 EAK88729.1 - 4.2 8.0 7.6 1.4 9.5 3.3 2.4 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region SMC_N PF02463.19 EAK88730.1 - 5.3e-54 183.0 33.1 1.2e-52 178.5 33.1 2.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EAK88730.1 - 7.1e-19 69.1 6.8 7.1e-19 69.1 6.8 7.6 3 2 3 6 6 3 1 AAA domain SMC_hinge PF06470.13 EAK88730.1 - 1.4e-15 57.6 0.0 9.3e-15 55.0 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EAK88730.1 - 2.9e-14 53.6 9.3 9.8e-09 35.4 1.5 5.2 4 1 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EAK88730.1 - 4.8e-07 29.4 0.0 1.3e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EAK88730.1 - 5.9e-07 29.5 37.4 5.9e-07 29.5 37.4 5.3 1 1 4 5 5 4 2 AAA ATPase domain SbcCD_C PF13558.6 EAK88730.1 - 0.00017 21.8 0.0 0.00084 19.5 0.0 2.2 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit T3SSipB PF16535.5 EAK88730.1 - 0.00071 20.1 0.6 0.00071 20.1 0.6 5.2 3 2 2 5 5 5 1 Type III cell invasion protein SipB ABC_tran PF00005.27 EAK88730.1 - 0.068 13.7 0.0 0.068 13.7 0.0 6.9 5 3 0 5 5 3 0 ABC transporter DASH_Hsk3 PF08227.11 EAK88730.1 - 0.078 13.4 2.0 46 4.5 0.0 5.0 5 0 0 5 5 5 0 DASH complex subunit Hsk3 like AAA_27 PF13514.6 EAK88730.1 - 0.27 10.8 0.0 0.27 10.8 0.0 4.6 6 0 0 6 6 6 0 AAA domain AAA_22 PF13401.6 EAK88730.1 - 7.7 6.8 11.8 3.4 7.9 0.0 4.8 5 1 1 6 6 5 0 AAA domain Polbeta PF18765.1 EAK88731.1 - 0.0011 19.0 0.1 0.004 17.2 0.1 2.1 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 EAK88731.1 - 0.013 15.8 0.0 0.034 14.4 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain MTBP_N PF14918.6 EAK88731.1 - 0.12 11.9 3.2 0.21 11.0 3.2 1.3 1 0 0 1 1 1 0 MDM2-binding Nrap_D2 PF17403.2 EAK88731.1 - 0.57 9.9 0.0 0.57 9.9 0.0 3.0 4 0 0 4 4 4 0 Nrap protein PAP/OAS-like domain Proteasom_PSMB PF10508.9 EAK88732.1 - 0.045 12.3 0.7 0.21 10.0 0.1 2.2 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit Sipho_Gp157 PF05565.11 EAK88733.1 - 0.00062 19.8 9.3 0.00062 19.8 9.3 3.6 4 0 0 4 4 4 1 Siphovirus Gp157 DUF4201 PF13870.6 EAK88733.1 - 0.0087 15.8 9.0 0.0087 15.8 9.0 4.7 3 1 2 5 5 5 1 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 EAK88733.1 - 0.011 15.8 12.3 0.011 15.8 12.3 5.0 3 2 2 5 5 5 0 TPR/MLP1/MLP2-like protein Mrpl_C PF18502.1 EAK88733.1 - 0.038 14.3 1.1 0.038 14.3 1.1 2.6 2 1 1 3 3 3 0 54S ribosomal protein L8 C-terminal domain Cas6b_C PF17262.2 EAK88733.1 - 0.17 12.0 3.2 0.18 11.9 0.4 2.5 2 1 0 2 2 2 0 Cas6b C-terminal domain DUF1759 PF03564.15 EAK88733.1 - 0.2 11.6 8.5 0.14 12.1 1.5 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1759) FUSC PF04632.12 EAK88733.1 - 1.4 7.4 3.6 2.2 6.7 3.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Lipoprotein_20 PF13942.6 EAK88733.1 - 4.9 7.0 20.3 0.63 9.9 10.6 3.0 2 2 0 2 2 2 0 YfhG lipoprotein ATG16 PF08614.11 EAK88733.1 - 6.5 6.9 34.6 0.092 13.0 14.2 3.7 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Hydrolase PF00702.26 EAK88734.1 - 3.9e-13 50.2 0.0 0.00021 21.6 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EAK88734.1 - 1.4e-12 47.5 0.0 1.4e-12 47.5 0.0 2.8 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EAK88734.1 - 0.0082 16.2 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) HAD_2 PF13419.6 EAK88734.1 - 0.067 13.3 0.0 0.98 9.5 0.0 2.6 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Nuc_sug_transp PF04142.15 EAK88735.1 - 1e-73 248.3 13.8 1.5e-73 247.7 13.8 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EAK88735.1 - 3e-07 30.7 27.9 8.6e-05 22.7 10.7 2.6 2 2 0 2 2 2 2 EamA-like transporter family TauE PF01925.19 EAK88735.1 - 0.0016 18.2 1.5 0.0016 18.2 1.5 3.3 2 1 1 3 3 3 1 Sulfite exporter TauE/SafE TPT PF03151.16 EAK88735.1 - 0.0025 17.2 11.8 0.0045 16.4 2.6 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family EmrE PF13536.6 EAK88735.1 - 0.018 14.7 5.8 0.088 12.4 5.8 2.0 1 1 0 1 1 1 0 Putative multidrug resistance efflux transporter DMT_6 PF04342.12 EAK88735.1 - 1.9 8.7 9.3 3.9 7.7 1.0 2.7 2 0 0 2 2 2 0 Putative member of DMT superfamily (DUF486) Nuc_sug_transp PF04142.15 EAK88736.1 - 1.5e-69 234.6 28.7 9.2e-47 159.7 8.5 2.0 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 EAK88736.1 - 1.9e-05 24.9 34.9 0.00021 21.5 10.8 3.3 3 1 1 4 4 4 2 EamA-like transporter family P63C PF10546.9 EAK88736.1 - 0.06 13.9 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 P63C domain TMEM234 PF10639.9 EAK88736.1 - 0.83 9.7 14.6 0.56 10.2 2.3 2.8 2 1 0 2 2 2 0 Putative transmembrane family 234 Sas10_Utp3 PF04000.15 EAK88737.1 - 0.048 14.3 0.6 0.21 12.2 0.3 2.2 2 0 0 2 2 2 0 Sas10/Utp3/C1D family DUF1981 PF09324.10 EAK88740.1 - 0.17 11.8 5.3 0.6 10.0 0.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) Taxilin PF09728.9 EAK88740.1 - 1.6 7.8 6.0 0.077 12.2 0.5 1.6 2 0 0 2 2 2 0 Myosin-like coiled-coil protein GPS PF01825.21 EAK88741.1 - 0.15 12.7 6.3 0.022 15.3 0.9 2.4 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif GIT_CC PF16559.5 EAK88741.1 - 0.25 11.3 0.6 1.2 9.1 0.1 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor SET PF00856.28 EAK88743.1 - 2 8.8 7.0 0.52 10.7 3.7 1.7 2 0 0 2 2 2 0 SET domain Glyco_hydro_129 PF11308.8 EAK88745.1 - 0.051 12.7 0.1 0.074 12.2 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases related to GH101 family, GH129 TcdB_N PF12918.7 EAK88746.1 - 0.029 14.6 0.5 0.029 14.6 0.5 2.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Dzip-like_N PF13815.6 EAK88747.1 - 0.037 14.0 1.7 0.053 13.5 0.0 2.1 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal TINF2_N PF14973.6 EAK88749.1 - 2.6 8.4 6.5 0.22 11.9 0.8 2.2 2 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus DUF148 PF02520.17 EAK88749.1 - 6.1 7.0 17.7 0.32 11.1 4.7 3.7 2 2 2 4 4 4 0 Domain of unknown function DUF148 GMC_oxred_N PF00732.19 EAK88750.1 - 2.2e-20 73.2 0.3 1.6e-09 37.6 0.0 2.3 2 0 0 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EAK88750.1 - 7.5e-10 39.5 0.0 4.3e-09 37.0 0.0 2.0 1 1 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EAK88750.1 - 1.2e-06 28.0 0.1 1.9e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EAK88750.1 - 8.8e-05 22.7 1.0 0.00022 21.4 1.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EAK88750.1 - 0.00024 20.8 0.4 0.00042 20.0 0.4 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EAK88750.1 - 0.00031 19.9 0.5 0.00049 19.3 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EAK88750.1 - 0.0014 17.7 0.2 0.002 17.2 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EAK88750.1 - 0.0075 15.0 0.1 0.011 14.4 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EAK88750.1 - 0.011 16.3 0.9 0.019 15.5 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EAK88750.1 - 0.011 14.9 0.1 0.016 14.3 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.16 EAK88750.1 - 0.022 14.4 0.2 0.042 13.5 0.2 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EAK88750.1 - 0.063 12.5 0.1 0.12 11.6 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EAK88750.1 - 0.24 10.7 1.3 0.42 9.9 1.3 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase AIG2_2 PF13772.6 EAK88751.1 - 0.068 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 AIG2-like family Peptidase_M24 PF00557.24 EAK88752.1 - 4.1e-36 124.6 0.0 5.3e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF2281 PF10047.9 EAK88754.1 - 0.026 15.2 0.1 0.078 13.7 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2281) RINGv PF12906.7 EAK88756.1 - 5.8e-12 45.5 6.7 7.9e-12 45.1 6.7 1.2 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EAK88756.1 - 0.5 10.7 7.6 7.7 6.9 8.6 2.1 1 1 1 2 2 2 0 Ring finger domain PseudoU_synth_2 PF00849.22 EAK88757.1 - 5.4e-22 78.6 0.1 9.6e-22 77.8 0.1 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EAK88757.1 - 0.0042 16.8 0.0 0.0079 15.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain AA_kinase PF00696.28 EAK88758.1 - 5.2e-38 131.0 0.4 7.8e-38 130.4 0.4 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EAK88758.1 - 8.3e-15 54.5 0.6 1.6e-14 53.6 0.2 1.8 2 0 0 2 2 2 1 PUA domain Pkinase PF00069.25 EAK88759.1 - 7.4e-46 156.6 0.0 1.4e-45 155.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88759.1 - 2e-30 106.0 0.0 3.9e-30 105.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EAK88759.1 - 0.0011 18.9 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4420 PF14390.6 EAK88762.1 - 0.015 14.6 0.1 0.018 14.3 0.1 1.1 1 0 0 1 1 1 0 Putative PD-(D/E)XK family member, (DUF4420) DUF2089 PF09862.9 EAK88762.1 - 0.038 14.0 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) DASH_Ask1 PF08655.10 EAK88762.1 - 0.052 13.4 1.7 0.053 13.4 0.0 1.8 2 0 0 2 2 2 0 DASH complex subunit Ask1 Dopey_N PF04118.14 EAK88763.1 - 5.6e-92 308.1 2.1 5.6e-92 308.1 2.1 3.5 4 0 0 4 4 4 1 Dopey, N-terminal B3_4 PF03483.17 EAK88763.1 - 0.058 13.1 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 B3/4 domain MA3 PF02847.17 EAK88764.1 - 8e-17 61.3 5.5 1.8e-07 31.1 0.3 3.5 3 0 0 3 3 3 3 MA3 domain PPDK_N PF01326.19 EAK88766.1 - 9.6e-09 34.9 0.0 2.4e-08 33.6 0.0 1.8 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Mad3_BUB1_I PF08311.12 EAK88766.1 - 0.024 14.6 0.2 3.9 7.5 0.0 2.8 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 C2 PF00168.30 EAK88767.1 - 3.7e-28 97.8 2.6 6.1e-05 23.3 0.0 6.6 7 0 0 7 7 7 4 C2 domain Ferlin_C PF16165.5 EAK88767.1 - 0.021 14.8 0.1 0.085 12.8 0.0 2.0 2 0 0 2 2 2 0 Ferlin C-terminus Insulin_TMD PF17870.1 EAK88767.1 - 0.091 12.8 1.7 0.31 11.1 1.7 1.9 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DnaJ PF00226.31 EAK88768.1 - 2.7e-19 69.0 1.4 2.7e-19 69.0 1.4 2.6 2 1 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 EAK88768.1 - 1.6e-10 41.0 0.3 4.8e-05 23.5 0.0 3.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EAK88768.1 - 1.4e-06 28.5 3.9 0.039 14.2 0.3 3.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain OmdA PF13376.6 EAK88768.1 - 0.037 14.0 1.5 13 5.9 0.0 3.1 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated Acetyltransf_11 PF13720.6 EAK88768.1 - 6.7 7.2 8.9 57 4.3 0.7 4.6 3 2 1 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 EMC3_TMCO1 PF01956.16 EAK88768.1 - 7.6 6.2 12.8 1.1 9.0 3.3 3.0 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Cyclin PF08613.11 EAK88769.1 - 5.6e-27 95.1 0.4 9.7e-27 94.3 0.4 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EAK88769.1 - 0.0047 16.7 0.1 0.015 15.0 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain PP2C PF00481.21 EAK88770.1 - 5.7e-13 49.1 0.0 1.2e-12 48.0 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EAK88770.1 - 0.051 13.2 0.0 0.16 11.6 0.0 1.7 1 1 0 1 1 1 0 Protein phosphatase 2C PA26 PF04636.13 EAK88772.1 - 1.5e-29 103.3 1.6 5.3e-22 78.4 0.0 2.3 2 1 0 2 2 2 2 PA26 p53-induced protein (sestrin) VWA_N2 PF16164.5 EAK88773.1 - 0.11 12.6 0.5 0.27 11.4 0.5 1.6 1 0 0 1 1 1 0 VWA N-terminal TcdB_N PF12918.7 EAK88774.1 - 9.1 6.7 17.3 2.7 8.3 0.6 4.4 3 1 3 6 6 6 0 TcdB toxin N-terminal helical domain RPN7 PF10602.9 EAK88775.1 - 2.1e-47 161.1 1.5 3.8e-47 160.2 1.5 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EAK88775.1 - 1.3e-13 51.4 1.3 3.5e-13 50.0 1.3 1.7 1 0 0 1 1 1 1 PCI domain COXG PF06240.13 EAK88776.1 - 0.023 14.4 0.8 0.031 14.0 0.8 1.2 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit G (CoxG) NGP1NT PF08153.12 EAK88777.1 - 6.8e-36 123.3 1.1 1.5e-35 122.2 1.1 1.5 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EAK88777.1 - 3.9e-17 62.4 0.0 6.3e-14 52.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAK88777.1 - 7.2e-07 29.3 0.0 2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EAK88777.1 - 4.2e-06 26.4 0.0 5.2e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 EAK88777.1 - 0.00014 21.4 0.1 0.28 10.6 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EAK88777.1 - 0.028 14.6 0.1 12 6.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EAK88777.1 - 0.097 12.7 6.4 1.3 9.0 0.1 3.5 3 1 1 4 4 4 0 Dynamin family EMC1_C PF07774.13 EAK88778.1 - 1.1e-24 87.4 8.6 2.2e-24 86.3 8.6 1.6 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal HMG_box PF00505.19 EAK88779.1 - 0.014 15.8 0.0 7.3 7.1 0.0 2.2 2 0 0 2 2 2 0 HMG (high mobility group) box TMEM132D_C PF15706.5 EAK88780.1 - 0.013 15.3 0.0 0.013 15.3 0.0 3.4 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term BSMAP PF12280.8 EAK88780.1 - 0.22 11.7 9.8 0.022 15.0 4.6 2.1 2 0 0 2 2 2 0 Brain specific membrane anchored protein MLANA PF14991.6 EAK88780.1 - 0.38 11.0 4.9 14 6.0 0.1 3.8 3 1 0 3 3 3 0 Protein melan-A FxsA PF04186.13 EAK88780.1 - 0.87 9.7 5.5 11 6.2 0.0 3.9 3 0 0 3 3 3 0 FxsA cytoplasmic membrane protein PFK PF00365.20 EAK88781.1 - 7.1e-62 209.3 0.0 2.6e-37 128.7 0.0 3.6 4 0 0 4 4 4 2 Phosphofructokinase Serglycin PF04360.12 EAK88781.1 - 0.083 12.8 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 Serglycin DUF1643 PF07799.12 EAK88781.1 - 0.15 12.3 0.0 28 4.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1643) Tfb2 PF03849.14 EAK88784.1 - 5e-46 157.3 7.0 8.5e-27 94.0 1.4 2.3 1 1 1 2 2 2 2 Transcription factor Tfb2 Tfb2_C PF18307.1 EAK88784.1 - 1.8e-08 34.6 1.1 2.8e-08 34.1 0.1 1.9 2 0 0 2 2 2 1 Transcription factor Tfb2 (p52) C-terminal domain UPF0261 PF06792.11 EAK88784.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) HTH_20 PF12840.7 EAK88784.1 - 0.22 11.6 0.0 8 6.6 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain DUF384 PF04064.13 EAK88785.1 - 1e-13 50.9 0.2 2.6e-13 49.6 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF384) DUF383 PF04063.14 EAK88785.1 - 3.4e-13 49.7 12.9 4.9e-09 36.1 3.8 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF383) RICTOR_M PF14666.6 EAK88785.1 - 0.0044 16.8 0.3 0.24 11.2 0.0 2.8 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, middle domain CagY_M PF07337.11 EAK88785.1 - 0.051 13.2 0.2 0.15 11.7 0.2 1.8 1 0 0 1 1 1 0 DC-EC Repeat Lar_restr_allev PF14354.6 EAK88786.1 - 0.43 11.0 2.9 15 6.1 0.1 3.3 3 1 0 3 3 3 0 Restriction alleviation protein Lar zf-RING_2 PF13639.6 EAK88786.1 - 0.65 10.4 6.3 0.23 11.8 0.6 2.4 2 0 0 2 2 2 0 Ring finger domain DUF3228 PF11539.8 EAK88787.1 - 5.3e-76 254.5 0.1 6.1e-76 254.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) PH_RBD PF12068.8 EAK88787.1 - 0.039 13.4 0.2 0.056 12.9 0.2 1.2 1 0 0 1 1 1 0 Rab-binding domain (RBD) DUF4261 PF14080.6 EAK88787.1 - 0.039 14.1 0.0 0.092 12.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) EF-hand_8 PF13833.6 EAK88788.1 - 2.6e-05 24.0 0.3 4.9e-05 23.1 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EAK88788.1 - 0.001 18.4 0.2 0.0022 17.4 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EAK88788.1 - 0.0055 17.1 0.3 0.0095 16.4 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EAK88788.1 - 0.024 14.5 0.4 0.067 13.2 0.4 1.8 1 0 0 1 1 1 0 EF-hand domain DUF4337 PF14235.6 EAK88788.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) EF-hand_5 PF13202.6 EAK88788.1 - 0.17 11.4 0.6 0.44 10.1 0.6 1.6 1 0 0 1 1 1 0 EF hand Claudin_2 PF13903.6 EAK88788.1 - 0.46 10.2 3.8 5.2 6.8 0.3 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction COPI_assoc PF08507.10 EAK88789.1 - 0.00013 22.0 0.5 0.00018 21.6 0.5 1.2 1 0 0 1 1 1 1 COPI associated protein MORN PF02493.20 EAK88790.1 - 3.9e-43 142.8 73.7 1.4e-07 30.9 1.8 10.3 10 0 0 10 10 10 9 MORN repeat ABC2_membrane_3 PF12698.7 EAK88791.1 - 0.016 14.3 5.4 0.021 13.9 5.4 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein V-SNARE_C PF12352.8 EAK88791.1 - 0.043 14.1 1.9 0.086 13.1 1.9 1.6 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus DUF3519 PF12033.8 EAK88791.1 - 0.083 13.3 2.9 0.16 12.4 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3519) Sec20 PF03908.13 EAK88791.1 - 0.43 10.5 6.6 0.16 11.9 3.2 1.9 2 0 0 2 2 2 0 Sec20 zf-MIZ PF02891.20 EAK88793.1 - 2.2e-15 56.1 1.7 2.2e-15 56.1 1.7 2.6 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger PHD PF00628.29 EAK88793.1 - 4e-06 26.6 13.2 2e-05 24.4 4.6 3.4 2 1 0 2 2 2 1 PHD-finger Rho_N PF07498.12 EAK88793.1 - 0.0041 17.0 0.3 0.01 15.8 0.3 1.7 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain Prok-RING_1 PF14446.6 EAK88793.1 - 0.0067 16.3 4.7 0.0067 16.3 4.7 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 Zf_RING PF16744.5 EAK88793.1 - 0.061 13.4 4.9 0.038 14.1 2.0 2.1 2 0 0 2 2 2 0 KIAA1045 RING finger DUF3337 PF11816.8 EAK88793.1 - 0.062 13.2 0.1 0.71 9.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3337) zf-Nse PF11789.8 EAK88793.1 - 0.14 12.0 1.6 0.53 10.1 1.6 2.1 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD_4 PF16866.5 EAK88793.1 - 1.6 8.9 7.0 21 5.3 3.3 2.9 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 EAK88793.1 - 1.7 8.6 11.0 0.079 12.9 4.1 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cupin_2 PF07883.11 EAK88794.1 - 0.0041 16.8 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain CENP-C_C PF11699.8 EAK88794.1 - 0.0051 17.0 0.5 0.0089 16.2 0.5 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like DUF4085 PF13315.6 EAK88794.1 - 0.073 12.7 0.1 0.095 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) GFP PF01353.22 EAK88794.1 - 0.089 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Green fluorescent protein RabGAP-TBC PF00566.18 EAK88796.1 - 3.4e-11 43.2 4.5 3.4e-11 43.2 4.5 5.0 5 0 0 5 5 5 3 Rab-GTPase-TBC domain NTP_transferase PF00483.23 EAK88798.1 - 1.5e-42 145.9 0.0 2.1e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EAK88798.1 - 1.4e-08 34.1 16.0 9.1e-08 31.5 4.2 3.3 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EAK88798.1 - 1.1e-06 29.1 0.0 1.5e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 EAK88798.1 - 0.0023 16.9 1.5 0.011 14.7 0.9 2.3 2 1 0 2 2 2 1 L-fucokinase DUF4954 PF16314.5 EAK88798.1 - 0.0069 14.6 0.8 0.011 13.9 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EAK88798.1 - 0.0092 15.7 4.5 0.0092 15.7 4.5 3.5 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Ipi1_N PF12333.8 EAK88799.1 - 0.0046 17.5 0.0 0.019 15.5 0.0 2.1 1 0 0 1 1 1 1 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.7 EAK88799.1 - 0.042 14.4 3.6 0.13 12.9 0.2 3.3 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region TBCC_N PF16752.5 EAK88799.1 - 3.8 8.0 7.9 1.1 9.8 0.4 2.7 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Thioredoxin_6 PF13848.6 EAK88800.1 - 2.9e-07 30.6 0.6 0.15 11.9 0.1 3.3 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin PF00085.20 EAK88800.1 - 0.00061 19.7 0.1 0.3 11.1 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin zf-RING_UBOX PF13445.6 EAK88801.1 - 4e-07 29.9 7.2 1.1e-06 28.6 7.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAK88801.1 - 2.2e-06 27.5 5.5 7.8e-06 25.8 5.6 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EAK88801.1 - 9.9e-06 25.3 7.8 2.1e-05 24.3 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK88801.1 - 5.9e-05 23.3 6.9 0.00013 22.2 6.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EAK88801.1 - 7.5e-05 22.5 5.1 0.00016 21.5 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EAK88801.1 - 0.00042 20.4 8.5 0.00099 19.2 8.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EAK88801.1 - 0.0014 18.4 9.0 0.011 15.5 9.3 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 EAK88801.1 - 0.97 9.2 5.8 2.4 8.0 5.8 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Prok-RING_4 PF14447.6 EAK88801.1 - 1.3 8.9 10.7 55 3.7 0.3 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 SWIRM PF04433.17 EAK88802.1 - 2e-31 108.2 0.9 2e-31 108.2 0.9 2.8 2 1 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EAK88802.1 - 3.2e-13 49.5 5.5 7.8e-13 48.2 5.5 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 EAK88802.1 - 5.3e-10 39.4 0.0 1.7e-09 37.8 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EAK88802.1 - 1.9e-09 37.6 0.0 5.6e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Phycobilisome PF00502.19 EAK88803.1 - 0.13 12.2 1.2 4.3 7.3 0.0 2.8 3 0 0 3 3 3 0 Phycobilisome protein TadE PF07811.12 EAK88805.1 - 0.4 11.0 1.3 0.88 9.9 1.3 1.6 1 0 0 1 1 1 0 TadE-like protein CBFD_NFYB_HMF PF00808.23 EAK88806.1 - 0.0002 21.5 3.1 0.00066 19.9 3.1 1.8 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone FHA_2 PF17913.1 EAK88806.1 - 0.0066 16.7 0.8 0.0091 16.2 0.8 1.2 1 0 0 1 1 1 1 FHA domain EMC3_TMCO1 PF01956.16 EAK88806.1 - 0.032 14.0 1.2 0.042 13.6 1.2 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF4467 PF14729.6 EAK88806.1 - 0.042 14.2 0.9 0.11 12.9 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function with cystatin-like fold (DUF4467) DUF5394 PF17372.2 EAK88806.1 - 0.24 10.9 7.3 0.3 10.6 7.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5394) ING PF12998.7 EAK88807.1 - 2e-13 50.8 4.5 2e-13 50.8 4.5 2.3 2 1 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EAK88807.1 - 3.6 7.5 16.4 12 5.9 16.4 1.9 1 1 0 1 1 1 0 PHD-finger DDOST_48kD PF03345.14 EAK88808.1 - 2.4e-92 309.9 4.3 3.2e-92 309.5 4.3 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Metallophos PF00149.28 EAK88809.1 - 8.5e-18 65.6 0.6 2e-17 64.4 0.6 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 EAK88809.1 - 9.7e-12 43.6 1.4 0.00073 18.9 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EAK88809.1 - 5.2e-11 42.8 0.9 0.00013 22.3 0.1 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK88809.1 - 3.6e-10 38.9 0.6 0.003 17.4 0.0 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EAK88809.1 - 3.8e-06 26.6 0.2 0.012 15.5 0.2 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EAK88809.1 - 0.0029 17.0 0.2 3.8 7.2 0.0 3.1 3 0 0 3 3 3 2 EF hand MCM PF00493.23 EAK88811.1 - 5.5e-86 287.3 0.0 9.1e-86 286.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EAK88811.1 - 2.5e-28 98.5 0.8 5.8e-28 97.3 0.8 1.7 1 1 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EAK88811.1 - 2.2e-19 69.6 1.2 1.6e-18 66.9 0.1 2.8 3 0 0 3 3 2 1 MCM AAA-lid domain MCM_N PF14551.6 EAK88811.1 - 6.6e-08 33.1 0.0 2.2e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EAK88811.1 - 2.8e-07 30.1 0.1 8e-05 22.1 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EAK88811.1 - 0.018 14.9 0.0 0.052 13.4 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF5137 PF17220.3 EAK88811.1 - 0.018 15.9 1.3 0.068 14.1 1.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF5137) AAA_5 PF07728.14 EAK88811.1 - 0.021 14.8 0.0 0.18 11.8 0.0 2.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EAK88811.1 - 0.022 14.5 0.0 0.2 11.3 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 EAK88811.1 - 0.024 15.1 0.0 0.097 13.1 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RcpC PF16976.5 EAK88811.1 - 0.04 14.0 0.4 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB AAA_16 PF13191.6 EAK88811.1 - 0.095 13.1 0.4 1.7 9.0 0.0 2.9 2 1 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 EAK88811.1 - 0.24 11.7 0.9 8.2 6.7 0.0 3.2 3 1 1 4 4 4 0 AAA domain Vps26 PF03643.15 EAK88812.1 - 5.1e-96 320.9 2.3 6.2e-96 320.6 2.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 zf-Mss51 PF13824.6 EAK88813.1 - 0.21 11.7 2.3 17 5.6 0.0 2.7 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-B_box PF00643.24 EAK88813.1 - 0.39 10.9 3.8 7.4 6.8 0.9 2.5 2 0 0 2 2 2 0 B-box zinc finger EGF_CA PF07645.15 EAK88814.1 - 2.5e-23 82.0 75.6 2.2e-11 43.8 4.9 7.3 6 0 0 6 6 6 4 Calcium-binding EGF domain cEGF PF12662.7 EAK88814.1 - 5.2e-17 61.4 40.5 4.5e-08 32.9 0.9 7.3 7 0 0 7 7 7 4 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EAK88814.1 - 1.1e-06 28.8 71.4 9e-05 22.7 10.0 7.6 7 1 1 8 8 8 5 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EAK88814.1 - 0.00038 20.6 14.7 0.00074 19.7 3.4 7.1 6 1 1 7 7 7 4 EGF domain hEGF PF12661.7 EAK88814.1 - 0.00074 20.1 58.1 0.0021 18.7 1.8 7.9 7 0 0 7 7 7 5 Human growth factor-like EGF EGF PF00008.27 EAK88814.1 - 0.00099 19.4 14.5 0.004 17.4 7.4 7.5 7 1 0 7 7 7 4 EGF-like domain EGF_MSP1_1 PF12946.7 EAK88814.1 - 0.017 15.2 2.2 0.017 15.2 2.2 6.7 5 1 1 6 6 6 0 MSP1 EGF domain 1 zf-LYAR PF08790.11 EAK88816.1 - 2.2e-13 49.8 7.2 2.2e-13 49.8 7.2 2.4 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger T4_baseplate PF12322.8 EAK88816.1 - 0.00025 20.6 4.5 0.00034 20.2 4.5 1.2 1 0 0 1 1 1 1 T4 bacteriophage base plate protein zf_UBZ PF18439.1 EAK88816.1 - 0.034 13.7 1.5 5.8 6.6 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cullin_Nedd8 PF10557.9 EAK88816.1 - 0.039 14.0 0.2 0.069 13.2 0.2 1.4 1 0 0 1 1 1 0 Cullin protein neddylation domain zf_C2H2_ZHX PF18387.1 EAK88816.1 - 9.8 5.9 7.9 3.3 7.4 1.1 2.6 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain NPR2 PF06218.11 EAK88817.1 - 5.7e-35 120.9 10.1 5.2e-33 114.5 6.2 2.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 CorA PF01544.18 EAK88818.1 - 7.1e-05 22.3 2.0 0.00019 20.9 0.1 2.3 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein MutS_III PF05192.18 EAK88818.1 - 0.13 12.5 0.5 0.39 10.9 0.0 2.0 2 1 0 2 2 2 0 MutS domain III TruD PF01142.18 EAK88819.1 - 2.5e-54 184.7 3.5 2.1e-50 171.8 0.2 3.7 3 1 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) DUF3967 PF13152.6 EAK88819.1 - 0.038 13.8 1.6 0.35 10.7 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3967) DUF1564 PF07600.11 EAK88819.1 - 0.18 11.5 9.2 0.055 13.2 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1564) PCI PF01399.27 EAK88820.1 - 7e-11 42.6 2.6 1.4e-10 41.6 1.2 2.2 2 0 0 2 2 2 1 PCI domain eIF3_N PF09440.10 EAK88820.1 - 9.6e-08 32.5 0.7 2.8e-07 31.1 0.7 1.8 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain RP-C_C PF11800.8 EAK88820.1 - 0.85 9.7 7.1 1.6 8.8 0.2 2.7 3 0 0 3 3 3 0 Replication protein C C-terminal region RRM_1 PF00076.22 EAK88821.1 - 1.8e-14 53.3 0.0 8.6e-11 41.5 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1084 PF06454.11 EAK88822.1 - 1.4e-13 50.9 22.5 2.7e-13 49.9 22.4 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1084) Bromo_TP PF07524.13 EAK88823.1 - 0.00053 19.9 0.0 0.0009 19.2 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.9 EAK88823.1 - 0.96 10.1 2.9 1.9 9.1 2.9 1.5 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term DUF1754 PF08555.10 EAK88824.1 - 2.3 9.1 7.7 8.3 7.3 7.7 1.9 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) MFS_1 PF07690.16 EAK88825.1 - 3.1e-21 75.7 31.6 3.1e-21 75.7 31.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EAK88825.1 - 1.6e-16 59.8 28.6 4.1e-12 45.2 1.6 3.1 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 EAK88825.1 - 5.5e-09 35.4 14.0 5.5e-09 35.4 14.0 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter Dynactin_p62 PF05502.13 EAK88826.1 - 4.1e-19 68.7 17.4 9.8e-14 51.0 10.5 2.2 2 0 0 2 2 2 2 Dynactin p62 family zf_UBZ PF18439.1 EAK88826.1 - 0.083 12.5 14.5 2.5 7.8 0.1 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 EAK88826.1 - 0.16 12.0 18.1 0.26 11.3 6.5 3.5 2 1 1 3 3 3 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EAK88826.1 - 0.48 10.4 17.5 0.36 10.8 0.6 4.0 3 1 0 3 3 3 0 zinc-ribbons DnaJ PF00226.31 EAK88827.1 - 5.5e-06 26.4 3.8 8.6e-06 25.8 0.4 2.3 2 0 0 2 2 2 1 DnaJ domain DUF953 PF06110.11 EAK88827.1 - 0.033 13.8 0.1 0.094 12.3 0.0 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) zf-C4_ClpX PF06689.13 EAK88827.1 - 4 7.4 6.4 16 5.5 0.4 3.0 3 0 0 3 3 3 0 ClpX C4-type zinc finger NYD-SP28_assoc PF14775.6 EAK88828.1 - 0.64 10.2 2.5 18 5.5 1.0 3.1 3 0 0 3 3 3 0 Sperm tail C-terminal domain DUF5582 PF17819.1 EAK88829.1 - 0.0062 17.0 3.3 0.0074 16.8 2.8 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF5582) Moulting_cycle PF04870.16 EAK88829.1 - 0.048 12.9 7.2 0.062 12.6 7.2 1.1 1 0 0 1 1 1 0 Moulting cycle Ndc1_Nup PF09531.10 EAK88829.1 - 0.47 9.1 4.4 0.47 9.1 4.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EAK88829.1 - 2.8 6.6 4.8 2.8 6.6 4.8 1.1 1 0 0 1 1 1 0 Presenilin FGF-BP1 PF06473.12 EAK88829.1 - 5.7 6.7 11.9 7.9 6.2 11.9 1.2 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Baculo_PEP_C PF04513.12 EAK88831.1 - 0.0019 18.3 15.9 0.14 12.2 9.4 3.4 2 2 1 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EAK88831.1 - 0.0044 17.1 6.2 0.0045 17.0 2.4 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EAK88831.1 - 0.0045 17.0 6.7 0.17 11.9 2.3 3.5 2 1 1 3 3 3 1 Laminin Domain II Syntaxin_2 PF14523.6 EAK88831.1 - 0.005 17.2 8.7 1.3 9.5 6.0 3.5 2 1 0 2 2 2 1 Syntaxin-like protein DUF2730 PF10805.8 EAK88831.1 - 0.039 14.1 0.6 0.24 11.5 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) NPV_P10 PF05531.12 EAK88831.1 - 0.096 13.2 15.2 0.13 12.7 1.3 4.3 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein HsbA PF12296.8 EAK88831.1 - 0.21 12.0 8.1 0.42 11.1 0.2 3.4 2 1 1 3 3 3 0 Hydrophobic surface binding protein A Rsbr_N PF08678.10 EAK88831.1 - 0.21 11.6 4.8 0.6 10.2 2.4 2.7 1 1 1 2 2 2 0 Rsbr N terminal Lipoprotein_2 PF00921.17 EAK88831.1 - 0.23 11.0 6.2 0.049 13.2 1.3 2.1 1 1 2 3 3 3 0 Borrelia lipoprotein DUF948 PF06103.11 EAK88831.1 - 0.25 11.6 6.3 2.2 8.6 0.6 3.8 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Cluap1 PF10234.9 EAK88831.1 - 0.31 10.4 5.1 0.62 9.4 5.1 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 COG2 PF06148.11 EAK88831.1 - 0.33 11.0 3.5 0.79 9.8 0.9 2.8 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5446 PF17522.2 EAK88831.1 - 0.59 10.3 5.7 3.3 7.9 1.3 3.3 2 1 1 3 3 3 0 Family of unknown function (DUF5446) PhaP_Bmeg PF09602.10 EAK88831.1 - 0.85 9.5 7.1 0.73 9.8 2.6 2.4 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) FidL_like PF15941.5 EAK88831.1 - 9.1 6.8 13.2 4.8 7.7 2.3 4.1 3 1 1 4 4 4 0 FidL-like putative membrane protein PI3_PI4_kinase PF00454.27 EAK88832.1 - 8e-44 150.3 0.1 1.9e-43 149.1 0.0 1.7 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase SPICE PF15678.5 EAK88832.1 - 0.29 10.5 4.2 0.45 9.8 4.2 1.2 1 0 0 1 1 1 0 Centriole duplication and mitotic chromosome congression MFS_1 PF07690.16 EAK88833.1 - 7e-07 28.5 15.6 7e-07 28.5 15.6 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily Pkinase PF00069.25 EAK88834.1 - 1e-77 261.1 0.0 1.7e-77 260.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88834.1 - 8.7e-33 113.7 0.0 1.4e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EAK88834.1 - 1.9e-26 89.6 7.6 2.1e-06 26.8 1.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAK88834.1 - 5.9e-25 87.5 4.0 2.9e-12 46.8 0.9 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EAK88834.1 - 6.7e-23 79.1 5.5 1e-06 28.0 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EAK88834.1 - 2.2e-21 73.9 5.3 3.6e-05 23.3 0.0 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EAK88834.1 - 4.9e-19 67.9 9.2 1.7e-09 37.4 1.0 4.3 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EAK88834.1 - 4.8e-07 30.1 1.4 0.017 15.4 0.3 2.9 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EAK88834.1 - 8.8e-06 26.0 0.4 0.0024 18.2 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 EAK88834.1 - 0.00069 19.5 2.4 0.31 11.0 0.5 3.0 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand APH PF01636.23 EAK88834.1 - 0.001 19.1 0.0 0.0027 17.7 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EAK88834.1 - 0.025 13.5 1.3 1.6 7.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1679) Kdo PF06293.14 EAK88834.1 - 0.055 12.8 0.0 0.15 11.4 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_13 PF17958.1 EAK88834.1 - 0.1 12.4 0.1 30 4.5 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain DUF1948 PF09185.10 EAK88835.1 - 0.39 10.6 2.4 0.36 10.7 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1948) Sec16 PF12932.7 EAK88836.1 - 0.095 13.3 0.8 0.32 11.6 0.1 2.1 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region ECH_2 PF16113.5 EAK88836.1 - 0.15 11.5 0.1 1.1 8.7 0.1 1.9 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Menin PF05053.13 EAK88836.1 - 0.5 8.7 4.2 0.73 8.1 4.2 1.2 1 0 0 1 1 1 0 Menin DUF842 PF05811.13 EAK88836.1 - 2.1 8.0 8.7 0.054 13.2 2.2 1.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) DDHD PF02862.17 EAK88837.1 - 2.2e-38 132.6 0.7 2.4e-36 126.0 0.0 2.6 3 0 0 3 3 3 1 DDHD domain DUF676 PF05057.14 EAK88837.1 - 3.4e-05 23.5 1.9 0.00035 20.1 1.9 2.2 1 1 0 1 1 1 1 Putative serine esterase (DUF676) LIDHydrolase PF10230.9 EAK88837.1 - 0.00051 19.7 0.7 0.001 18.7 0.3 1.6 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase PGAP1 PF07819.13 EAK88837.1 - 0.0012 18.6 0.2 0.034 13.9 0.0 2.6 2 0 0 2 2 2 1 PGAP1-like protein Lipase_3 PF01764.25 EAK88837.1 - 0.0019 18.1 0.0 0.0046 16.8 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) LCAT PF02450.15 EAK88837.1 - 0.0049 16.1 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EAK88837.1 - 0.013 14.8 0.0 0.034 13.4 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK88837.1 - 0.015 14.9 0.0 0.056 13.1 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EAK88837.1 - 0.028 15.0 0.0 0.042 14.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family COG2 PF06148.11 EAK88838.1 - 7.1e-05 22.9 3.2 0.00043 20.4 2.6 2.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 EAK88838.1 - 0.00068 20.0 2.5 0.0057 17.0 0.1 3.6 3 1 0 3 3 3 1 Domain of unknown function (DUF3510) Guanylate_cyc PF00211.20 EAK88839.1 - 3.8e-14 52.7 0.0 1e-13 51.3 0.0 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Afaf PF15339.6 EAK88839.1 - 0.2 11.4 4.7 1.2 8.8 0.3 2.3 2 0 0 2 2 2 0 Acrosome formation-associated factor DUF4818 PF16089.5 EAK88839.1 - 0.81 10.2 4.6 2 8.9 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4818) PTS_2-RNA PF01885.16 EAK88841.1 - 2.2e-51 174.5 0.1 2.9e-51 174.1 0.1 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Methyltransf_15 PF09445.10 EAK88842.1 - 9.7e-25 87.1 1.6 3.7e-14 52.6 0.1 2.5 2 0 0 2 2 2 2 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 EAK88842.1 - 0.00053 19.7 0.0 0.0016 18.1 0.0 1.8 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EAK88842.1 - 0.049 14.3 0.0 0.26 12.0 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain Steroid_dh PF02544.16 EAK88843.1 - 1.5e-32 112.7 8.2 3.1e-32 111.7 8.2 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 EAK88843.1 - 1.5e-05 24.6 0.0 2.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_4 PF18036.1 EAK88843.1 - 0.0004 20.4 0.0 0.15 12.2 0.0 2.6 1 1 1 2 2 2 2 Ubiquitin-like domain MFS_1 PF07690.16 EAK88843.1 - 0.056 12.4 8.2 0.076 11.9 8.2 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily PalH PF08733.10 EAK88843.1 - 1.9 7.4 10.8 1.7 7.6 1.2 2.4 1 1 0 2 2 2 0 PalH/RIM21 Paf67 PF10255.9 EAK88844.1 - 3.7e-101 339.0 4.2 3.7e-101 339.0 4.2 1.4 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EAK88844.1 - 0.0033 17.4 0.0 0.0085 16.1 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Amelotin PF15757.5 EAK88844.1 - 0.63 9.6 3.6 0.86 9.1 0.1 2.5 3 0 0 3 3 3 0 Amelotin Pox_E10 PF04805.12 EAK88844.1 - 1.5 8.8 8.9 3.5 7.6 2.4 3.1 3 0 0 3 3 3 0 E10-like protein conserved region Syntaxin PF00804.25 EAK88845.1 - 2.5e-22 79.5 15.6 3.2e-22 79.2 15.6 1.1 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EAK88845.1 - 1.2e-12 47.6 0.7 2.7e-12 46.5 0.7 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 EAK88845.1 - 6.9e-05 23.2 18.1 0.0036 17.6 8.4 2.4 2 0 0 2 2 2 2 Syntaxin-like protein CDT1 PF08839.11 EAK88845.1 - 0.0065 16.8 4.4 0.084 13.2 0.3 2.4 1 1 0 2 2 2 1 DNA replication factor CDT1 like Gemini_BL1 PF00845.19 EAK88845.1 - 0.013 15.1 1.2 0.017 14.7 1.2 1.3 1 0 0 1 1 1 0 Geminivirus BL1 movement protein CTK3 PF12243.8 EAK88845.1 - 0.026 14.5 1.2 0.071 13.1 0.2 2.1 1 1 1 2 2 2 0 CTD kinase subunit gamma CTK3 Orf78 PF06024.12 EAK88845.1 - 0.04 14.2 0.3 0.04 14.2 0.3 2.5 3 0 0 3 3 3 0 Orf78 (ac78) DUF846 PF05832.12 EAK88845.1 - 0.096 12.7 0.9 0.13 12.3 0.1 1.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF846) DUF2116 PF09889.9 EAK88845.1 - 0.11 12.6 1.3 0.29 11.1 1.3 1.7 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF1676 PF07898.13 EAK88845.1 - 0.12 12.4 6.6 1.5 8.9 6.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) Mit_KHE1 PF10173.9 EAK88845.1 - 5.4 7.1 16.1 6.5 6.8 8.7 2.3 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF2203 PF09969.9 EAK88845.1 - 5.8 7.7 12.2 12 6.6 3.5 3.2 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF745 PF05335.13 EAK88845.1 - 6.2 6.5 10.4 7.3 6.3 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Ribosomal_L27A PF00828.19 EAK88845.1 - 6.5 7.4 10.1 4.2 8.0 6.4 2.4 2 1 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A ThiF PF00899.21 EAK88847.1 - 1.4e-54 185.1 0.0 1.9e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EAK88847.1 - 2.1e-07 31.4 0.2 1.1e-06 29.1 0.1 2.2 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 EAK88847.1 - 0.013 15.6 0.5 0.028 14.5 0.1 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EAK88847.1 - 0.039 13.8 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PglD_N PF17836.1 EAK88847.1 - 0.067 13.8 0.2 0.42 11.3 0.2 2.3 2 0 0 2 2 2 0 PglD N-terminal domain UDPG_MGDP_dh_N PF03721.14 EAK88847.1 - 0.11 12.1 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ELFV_dehydrog PF00208.21 EAK88847.1 - 0.14 11.9 0.1 0.22 11.2 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 EAK88847.1 - 0.16 11.4 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ribosomal_S25 PF03297.15 EAK88848.1 - 1.1e-35 121.8 3.1 1.3e-35 121.6 3.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Phage_FRD3 PF05798.11 EAK88849.1 - 0.074 13.3 3.7 0.7 10.2 0.3 3.6 2 1 0 2 2 2 0 Bacteriophage FRD3 protein Gly_radical PF01228.21 EAK88849.1 - 0.086 13.4 0.3 0.89 10.1 0.0 2.7 3 0 0 3 3 3 0 Glycine radical Kinase-PPPase PF03618.14 EAK88849.1 - 0.097 12.4 2.1 1.1 8.9 0.2 2.3 1 1 0 2 2 2 0 Kinase/pyrophosphorylase MCM PF00493.23 EAK88850.1 - 1.1e-99 332.0 0.1 1.9e-99 331.3 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EAK88850.1 - 4.4e-36 123.5 0.1 9.1e-36 122.5 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EAK88850.1 - 5.1e-25 87.7 0.2 1.5e-24 86.2 0.2 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 EAK88850.1 - 7.6e-18 65.3 16.6 7.6e-18 65.3 16.6 2.0 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 EAK88850.1 - 8.8e-14 52.0 0.3 8.8e-14 52.0 0.3 3.3 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 EAK88850.1 - 5.5e-07 29.2 0.0 3.7e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EAK88850.1 - 0.00017 21.4 0.0 0.00051 19.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EAK88850.1 - 0.00018 21.5 0.0 0.00041 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EAK88850.1 - 0.0056 16.4 0.0 0.063 13.0 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain MBOAT PF03062.19 EAK88851.1 - 2.3e-20 73.3 32.8 7.7e-20 71.5 32.8 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EAK88851.1 - 3.1 8.1 10.5 0.25 11.7 4.5 2.4 3 0 0 3 3 3 0 Membrane bound O-acyl transferase family Pkinase PF00069.25 EAK88852.1 - 1.5e-78 263.8 0.0 2.2e-78 263.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88852.1 - 1.4e-35 122.8 0.0 2.9e-35 121.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EAK88852.1 - 9.1e-27 90.6 6.1 3.7e-08 32.3 2.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAK88852.1 - 2.2e-23 82.5 0.2 2.6e-11 43.8 0.3 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK88852.1 - 9.3e-22 75.1 3.3 7.9e-06 25.4 0.0 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EAK88852.1 - 5.1e-17 60.5 6.6 0.00061 19.2 1.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EAK88852.1 - 1.3e-14 53.7 7.8 0.00072 19.4 0.7 5.2 3 1 2 5 5 5 3 EF-hand domain pair EF-hand_4 PF12763.7 EAK88852.1 - 1.5e-05 24.9 0.5 0.23 11.4 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Pkinase_fungal PF17667.1 EAK88852.1 - 1.5e-05 23.9 0.0 2.3e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EAK88852.1 - 0.0011 18.4 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like EF-hand_9 PF14658.6 EAK88852.1 - 0.0016 18.7 0.0 0.11 12.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain Kdo PF06293.14 EAK88852.1 - 0.0069 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAK88852.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family SPARC_Ca_bdg PF10591.9 EAK88852.1 - 0.065 13.6 0.1 22 5.4 0.1 3.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EAK88852.1 - 0.1 12.8 3.1 0.83 9.9 1.4 3.3 3 1 1 4 4 4 0 Dockerin type I domain PCI PF01399.27 EAK88854.1 - 6.8e-08 33.0 0.1 6.8e-08 33.0 0.1 2.9 3 0 0 3 3 3 1 PCI domain RRM_1 PF00076.22 EAK88855.1 - 2.2e-13 49.8 0.0 8e-11 41.6 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1897 PF09005.10 EAK88855.1 - 0.21 11.1 0.5 0.39 10.2 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1897) TGT PF01702.18 EAK88856.1 - 1e-29 103.8 0.0 2.9e-29 102.3 0.0 1.7 2 0 0 2 2 2 1 Queuine tRNA-ribosyltransferase ERM PF00769.19 EAK88858.1 - 0.0015 18.4 25.4 0.0015 18.4 25.4 1.6 2 0 0 2 2 2 1 Ezrin/radixin/moesin family Tcp10_C PF07202.13 EAK88858.1 - 0.0018 18.2 0.1 0.0018 18.2 0.1 2.8 2 1 1 3 3 3 1 T-complex protein 10 C-terminus Exonuc_VII_L PF02601.15 EAK88858.1 - 0.055 13.0 9.2 0.089 12.3 9.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit PPTA PF01239.22 EAK88859.1 - 0.15 11.8 5.7 12 5.8 0.2 4.6 4 0 0 4 4 4 0 Protein prenyltransferase alpha subunit repeat Peptidase_M16 PF00675.20 EAK88861.1 - 1.7e-33 115.7 0.0 3.3e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EAK88861.1 - 2.3e-32 112.4 9.4 4.3e-32 111.5 3.4 2.8 3 0 0 3 3 3 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EAK88861.1 - 5e-27 95.1 1.0 1.5e-17 64.2 0.1 3.3 3 1 0 3 3 3 2 Peptidase M16 inactive domain Thioredoxin_2 PF13098.6 EAK88861.1 - 0.13 12.7 0.2 0.49 10.9 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Ccdc124 PF06244.12 EAK88863.1 - 3.2e-28 98.9 35.8 3.2e-25 89.1 35.8 2.7 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 EAK88863.1 - 1.1e-05 25.7 0.8 1.1e-05 25.7 0.8 3.3 2 1 0 2 2 2 1 HMG (high mobility group) box DUF1002 PF06207.11 EAK88863.1 - 0.0022 17.5 2.0 0.004 16.7 2.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1002) CHDNT PF08073.12 EAK88863.1 - 0.043 13.8 0.4 0.12 12.3 0.4 1.8 1 0 0 1 1 1 0 CHDNT (NUC034) domain Hydin_ADK PF17213.3 EAK88863.1 - 5 7.4 13.7 5.5 7.2 13.3 1.4 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain Strep_pep PF14404.6 EAK88864.1 - 0.15 12.4 0.0 12 6.3 0.0 2.3 2 0 0 2 2 2 0 Ribosomally synthesized peptide in Streptomyces species DUF846 PF05832.12 EAK88865.1 - 9.8e-42 142.3 20.8 1.3e-41 141.9 20.8 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) SUI1 PF01253.22 EAK88866.1 - 1.6e-24 86.2 0.0 2.1e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 MFS_1 PF07690.16 EAK88867.1 - 7.4e-15 54.7 37.1 1.7e-13 50.3 31.5 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily LCCL PF03815.19 EAK88868.1 - 2.7e-88 290.3 19.3 5.5e-24 84.1 0.4 5.1 5 0 0 5 5 5 4 LCCL domain SRCR PF00530.18 EAK88868.1 - 1.3e-34 118.7 12.8 1.7e-17 63.8 6.8 2.8 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Laminin_G_3 PF13385.6 EAK88868.1 - 1.3e-17 64.4 0.4 3.2e-17 63.1 0.4 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PLAT PF01477.23 EAK88868.1 - 2.4e-14 53.9 0.1 2.7e-11 44.1 0.0 2.7 2 0 0 2 2 2 2 PLAT/LH2 domain Rxt3 PF08642.10 EAK88868.1 - 4.3e-09 37.2 0.0 0.015 16.1 0.1 4.6 4 1 0 4 4 4 2 Histone deacetylation protein Rxt3 Pentaxin PF00354.17 EAK88868.1 - 6.3e-05 22.8 0.1 0.00013 21.7 0.1 1.4 1 0 0 1 1 1 1 Pentaxin family SRCR_2 PF15494.6 EAK88868.1 - 9.5e-05 22.9 2.0 9.5e-05 22.9 2.0 3.0 3 0 0 3 3 3 1 Scavenger receptor cysteine-rich domain Sialidase PF02973.16 EAK88868.1 - 0.00022 20.8 0.3 0.0005 19.6 0.3 1.5 1 0 0 1 1 1 1 Sialidase, N-terminal domain Hepsin-SRCR PF09272.10 EAK88868.1 - 0.095 13.2 0.5 7 7.2 0.2 2.7 2 0 0 2 2 2 0 Hepsin, SRCR domain Bac_surface_Ag PF01103.23 EAK88870.1 - 2.9e-14 53.3 7.7 6.3e-14 52.2 7.7 1.5 1 1 0 1 1 1 1 Surface antigen IBN_N PF03810.19 EAK88870.1 - 0.03 14.2 0.1 0.071 13.0 0.1 1.6 1 0 0 1 1 1 0 Importin-beta N-terminal domain Tau95 PF09734.9 EAK88871.1 - 2.1e-28 99.9 0.0 5.5e-28 98.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EAK88871.1 - 8.9e-14 51.8 0.1 1.2e-10 41.6 0.0 2.8 2 1 1 3 3 3 2 Tau95 Triple barrel domain WD40 PF00400.32 EAK88872.1 - 4.1e-12 46.4 0.5 0.058 14.3 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK88872.1 - 0.0058 16.9 0.0 7 7.0 0.0 4.2 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Vps5 PF09325.10 EAK88873.1 - 0.0076 15.8 4.2 0.013 15.1 4.2 1.3 1 0 0 1 1 1 1 Vps5 C terminal like SCVP PF17619.2 EAK88873.1 - 0.18 12.7 1.4 1.4 9.9 0.0 2.8 2 1 1 3 3 3 0 Secreted clade V proteins Peptidase_C97 PF05903.14 EAK88874.1 - 2.3e-29 102.1 0.0 4.8e-29 101.1 0.0 1.5 2 0 0 2 2 2 1 PPPDE putative peptidase domain UL41A PF17591.2 EAK88876.1 - 0.022 14.9 0.0 0.19 11.8 0.0 2.5 2 0 0 2 2 2 0 Herpesvirus UL41A zf-RING_UBOX PF13445.6 EAK88877.1 - 0.015 15.3 2.2 0.015 15.3 2.2 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EAK88877.1 - 0.88 9.8 8.4 7.4 6.8 3.7 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EAK88877.1 - 1.1 9.6 9.8 6.5 7.2 3.0 2.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 EAK88877.1 - 1.3 8.9 12.3 1.4 8.8 5.1 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAK88877.1 - 1.5 8.7 12.5 0.28 11.1 2.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK88877.1 - 1.7 8.7 11.6 0.098 12.6 3.2 2.6 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EAK88877.1 - 4.9 7.1 13.4 9.4 6.2 5.6 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 TBPIP PF07106.13 EAK88878.1 - 1.3e-24 85.9 0.8 2.5e-24 85.0 0.8 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain TFIIE_beta PF02186.15 EAK88878.1 - 0.0043 17.3 0.8 0.21 11.9 0.0 2.6 2 0 0 2 2 2 1 TFIIE beta subunit core domain DUF4777 PF16007.5 EAK88878.1 - 0.087 13.1 0.0 2.2 8.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) Sad1_UNC PF07738.13 EAK88879.1 - 1.4e-13 51.0 0.8 4.2e-13 49.5 0.8 1.8 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal DASH_Dam1 PF08653.10 EAK88879.1 - 0.93 9.4 3.6 7 6.5 0.1 2.9 2 0 0 2 2 2 0 DASH complex subunit Dam1 Fib_alpha PF08702.10 EAK88879.1 - 4.3 7.5 14.4 1.7 8.8 10.1 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Metallophos PF00149.28 EAK88880.1 - 0.0027 18.2 0.4 0.0042 17.6 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NOPS PF08075.11 EAK88880.1 - 0.15 12.3 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 NOPS (NUC059) domain Cpn60_TCP1 PF00118.24 EAK88881.1 - 1.6e-147 492.1 3.6 1.8e-147 491.9 3.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Prolamin_like PF05617.11 EAK88881.1 - 0.41 10.9 1.8 0.67 10.2 0.3 2.0 2 0 0 2 2 2 0 Prolamin-like Hamartin PF04388.12 EAK88882.1 - 4.7 5.8 26.9 5.6 5.5 26.9 1.1 1 0 0 1 1 1 0 Hamartin protein IRK_C PF17655.1 EAK88883.1 - 1.6e-08 34.4 0.0 2.6e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EAK88883.1 - 9.3e-07 28.7 11.0 4.1e-06 26.6 11.0 1.9 1 1 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 EAK88883.1 - 1.3 9.0 13.0 2.1 8.4 12.0 1.9 1 1 0 1 1 1 0 Ion channel TRAPPC10 PF12584.8 EAK88884.1 - 0.0064 16.2 0.0 0.018 14.7 0.0 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Ku_PK_bind PF08785.11 EAK88885.1 - 0.025 14.7 0.5 0.13 12.5 0.5 2.2 1 0 0 1 1 1 0 Ku C terminal domain like Solute_trans_a PF03619.16 EAK88886.1 - 5.9e-09 35.8 20.3 9.3e-09 35.2 20.3 1.3 1 0 0 1 1 1 1 Organic solute transporter Ostalpha CstA_5TM PF13722.6 EAK88886.1 - 0.28 11.6 2.4 0.62 10.4 0.2 2.3 2 0 0 2 2 2 0 5TM C-terminal transporter carbon starvation CstA DUF2976 PF11190.8 EAK88886.1 - 0.56 10.0 4.6 0.98 9.3 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2976) TFIIA PF03153.13 EAK88886.1 - 0.97 9.4 35.2 1.3 9.0 35.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BRCT_2 PF16589.5 EAK88887.1 - 4.4e-06 27.0 5.1 0.03 14.7 1.8 3.2 3 1 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EAK88887.1 - 0.00041 20.7 1.6 0.26 11.7 0.0 3.9 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain DUF1241 PF06840.11 EAK88888.1 - 0.023 14.3 0.4 0.071 12.8 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1241) DUF4611 PF15387.6 EAK88888.1 - 0.34 11.2 16.1 0.38 11.0 3.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 EAK88888.1 - 5.2 6.7 10.5 12 5.6 1.1 2.5 2 0 0 2 2 2 0 FAM176 family Peptidase_S49_N PF08496.10 EAK88888.1 - 6 6.9 6.2 14 5.7 0.1 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal HsdM_N PF12161.8 EAK88888.1 - 6.2 7.4 13.3 0.85 10.2 9.2 1.6 2 0 0 2 2 2 0 HsdM N-terminal domain Porin_3 PF01459.22 EAK88890.1 - 0.0011 18.5 2.1 0.0011 18.5 2.1 2.6 2 1 0 2 2 2 1 Eukaryotic porin Ribosomal_S6e PF01092.19 EAK88891.1 - 8.3e-55 184.1 0.0 1.7e-54 183.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Peptidase_M16 PF00675.20 EAK88892.1 - 1.6e-22 80.1 1.6 1.2e-20 74.0 0.0 3.2 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88892.1 - 3.5e-15 56.5 0.4 7.5e-10 39.1 0.1 3.7 3 0 0 3 3 3 3 Peptidase M16 inactive domain Peptidase_M16_M PF16187.5 EAK88892.1 - 4.5e-13 49.1 1.5 8.9e-13 48.2 1.5 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 GAD PF02938.14 EAK88892.1 - 0.005 17.1 0.0 1.7 8.9 0.0 2.7 2 0 0 2 2 2 2 GAD domain IZUMO PF15005.6 EAK88892.1 - 7.4 7.1 6.8 1.3 9.5 0.7 2.9 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Pyr_redox_2 PF07992.14 EAK88893.1 - 9.6e-58 195.7 0.1 1.2e-57 195.4 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EAK88893.1 - 7.9e-22 77.6 0.0 2e-21 76.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EAK88893.1 - 2.3e-16 60.1 1.7 1.2e-11 45.0 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EAK88893.1 - 5e-12 45.7 0.1 2.3e-08 33.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EAK88893.1 - 1.7e-08 33.6 0.7 0.00017 20.4 1.5 2.3 1 1 1 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EAK88893.1 - 4.7e-08 32.5 1.5 2.6e-06 26.8 1.1 2.5 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 EAK88893.1 - 5e-06 26.0 0.1 0.0034 16.7 0.1 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EAK88893.1 - 8.7e-06 25.1 0.0 2e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EAK88893.1 - 1.6e-05 24.5 0.4 2.4e-05 23.9 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EAK88893.1 - 0.00012 22.3 1.7 0.00082 19.6 0.3 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EAK88893.1 - 0.00013 21.3 0.3 1.1 8.4 0.0 3.2 3 0 0 3 3 3 2 FAD binding domain Thi4 PF01946.17 EAK88893.1 - 0.0024 17.2 0.8 0.0062 15.8 0.3 1.9 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 EAK88893.1 - 0.012 14.8 0.0 0.031 13.4 0.0 1.6 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EAK88893.1 - 0.014 15.0 2.1 0.044 13.4 0.5 2.2 1 1 0 2 2 2 0 FAD dependent oxidoreductase TPR_MLP1_2 PF07926.12 EAK88894.1 - 0.0027 17.8 13.4 0.0027 17.8 13.4 2.6 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein FliJ PF02050.16 EAK88894.1 - 0.24 11.6 17.8 0.13 12.4 8.2 2.7 2 0 0 2 2 2 0 Flagellar FliJ protein Seryl_tRNA_N PF02403.22 EAK88894.1 - 0.64 10.3 31.5 0.28 11.4 8.5 4.1 3 2 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 EAK88894.1 - 5.5 6.3 11.4 8.8 5.6 11.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PI_PP_I PF18363.1 EAK88894.1 - 6 7.1 7.5 2.2 8.5 2.9 2.6 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain MbeD_MobD PF04899.12 EAK88894.1 - 6.6 6.9 12.1 16 5.7 0.4 3.3 2 1 1 3 3 3 0 MbeD/MobD like Tim17 PF02466.19 EAK88895.1 - 1.5e-25 89.7 6.8 2e-25 89.3 6.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family MMR_HSR1 PF01926.23 EAK88896.1 - 9.2e-15 54.7 0.0 1.7e-13 50.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAK88896.1 - 1.5e-05 24.6 0.0 0.00024 20.7 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EAK88896.1 - 0.0035 17.3 0.0 0.57 10.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase SDA1 PF05285.12 EAK88896.1 - 2.3 7.6 24.0 0.034 13.6 14.9 2.0 2 0 0 2 2 2 0 SDA1 CDC45 PF02724.14 EAK88896.1 - 9.7 4.3 13.8 0.041 12.2 4.8 1.6 2 0 0 2 2 2 0 CDC45-like protein Presenilin PF01080.17 EAK88896.1 - 10 4.8 8.7 16 4.1 8.7 1.2 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 EAK88897.1 - 3.2e-37 128.3 13.4 1e-33 116.9 7.6 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK88897.1 - 2.8e-27 95.6 1.4 2.4e-23 82.8 0.2 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EAK88897.1 - 4.1e-05 23.1 0.1 0.00025 20.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EAK88897.1 - 0.0062 15.9 0.9 0.011 15.1 0.2 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EAK88897.1 - 0.0088 15.7 1.7 0.36 10.4 0.1 2.6 2 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EAK88897.1 - 0.011 14.5 3.2 0.032 13.0 0.2 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EAK88897.1 - 0.022 14.7 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EAK88897.1 - 0.13 11.8 6.3 0.19 11.3 0.2 2.5 2 0 0 2 2 2 0 RIO1 family WD40 PF00400.32 EAK88898.1 - 0.0056 17.5 1.7 1.2 10.2 0.1 4.1 5 0 0 5 5 5 1 WD domain, G-beta repeat zf-CHY PF05495.12 EAK88899.1 - 1.3e-12 48.1 11.6 1.3e-12 48.1 11.6 3.6 2 1 1 3 3 3 1 CHY zinc finger Myb_DNA-binding PF00249.31 EAK88899.1 - 1.9e-07 31.1 0.2 4.3e-07 30.0 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Trs65 PF12735.7 EAK88899.1 - 0.096 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 zinc_ribbon_12 PF11331.8 EAK88899.1 - 0.9 9.4 12.1 0.2 11.5 2.5 3.8 3 1 1 4 4 4 0 Probable zinc-ribbon domain UCH PF00443.29 EAK88900.1 - 3.6e-37 128.2 2.1 4.9e-37 127.8 2.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK88900.1 - 7.5e-08 32.3 9.1 1.1e-06 28.5 9.1 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2073 PF09846.9 EAK88900.1 - 0.1 12.4 0.0 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) zf-HIT PF04438.16 EAK88900.1 - 1.9 8.4 6.9 4 7.4 0.6 2.4 2 0 0 2 2 2 0 HIT zinc finger CSN8_PSD8_EIF3K PF10075.9 EAK88901.1 - 4.1e-22 78.7 0.5 6.9e-22 78.0 0.5 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EAK88901.1 - 1.7e-06 27.7 1.1 2.3e-06 27.2 1.1 1.1 1 0 0 1 1 1 1 SAC3/GANP family FKBP26_C PF18046.1 EAK88901.1 - 0.094 12.8 0.3 2.6 8.2 0.0 2.7 2 1 0 2 2 2 0 FKBP26_C-terminal Peptidase_C1 PF00112.23 EAK88902.1 - 5.4e-31 108.4 18.1 7.2e-21 75.3 1.7 3.0 2 1 0 2 2 2 2 Papain family cysteine protease CathepsinC_exc PF08773.11 EAK88902.1 - 6e-13 49.1 4.6 9.2e-12 45.3 4.6 2.6 1 1 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EAK88902.1 - 0.00016 20.6 0.6 0.00036 19.4 0.6 1.5 1 0 0 1 1 1 1 Peptidase C1-like family DUF4746 PF15928.5 EAK88902.1 - 0.032 13.6 10.9 0.054 12.9 10.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop14 PF04147.12 EAK88902.1 - 0.038 12.2 21.9 0.057 11.6 21.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EAK88902.1 - 0.081 11.2 16.2 0.11 10.7 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.11 EAK88902.1 - 0.52 10.3 9.6 0.94 9.5 9.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) LAP1C PF05609.12 EAK88902.1 - 0.97 8.5 15.8 33 3.4 0.0 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 EAK88902.1 - 0.97 8.1 14.7 1.5 7.5 14.7 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EAK88902.1 - 1.2 7.6 12.1 2 6.9 12.1 1.2 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 EAK88902.1 - 6.3 6.8 8.0 11 6.0 8.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BUD22 PF09073.10 EAK88902.1 - 6.8 5.9 28.0 14 4.9 28.0 1.4 1 0 0 1 1 1 0 BUD22 DDRGK PF09756.9 EAK88902.1 - 10 5.7 29.9 23 4.5 29.9 1.5 1 0 0 1 1 1 0 DDRGK domain ArfGap PF01412.18 EAK88903.1 - 1.4e-31 109.0 0.1 5.5e-31 107.1 0.1 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ribosomal_S28e PF01200.18 EAK88904.1 - 4.2e-31 106.7 0.8 4.6e-31 106.6 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e PH PF00169.29 EAK88905.1 - 1.6e-07 31.8 0.6 9.6e-07 29.3 0.6 2.4 1 0 0 1 1 1 1 PH domain Ank_5 PF13857.6 EAK88905.1 - 0.0011 19.2 0.0 0.004 17.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAK88905.1 - 0.0075 16.8 0.2 0.16 12.6 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK88905.1 - 0.015 15.9 0.2 1.6 9.4 0.1 2.9 1 1 1 2 2 2 0 Ankyrin repeats (many copies) PH_11 PF15413.6 EAK88905.1 - 0.042 14.3 0.0 0.67 10.4 0.0 3.0 1 1 0 1 1 1 0 Pleckstrin homology domain Ank PF00023.30 EAK88905.1 - 0.11 13.0 2.8 11 6.7 0.0 4.4 5 0 0 5 5 4 0 Ankyrin repeat DUF3251 PF11622.8 EAK88905.1 - 0.23 11.1 1.3 0.49 10.0 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3251) DUF1664 PF07889.12 EAK88905.1 - 1.4 9.0 14.3 0.029 14.4 4.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 EAK88905.1 - 1.8 8.3 9.4 2.1 8.1 2.3 3.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain ATG16 PF08614.11 EAK88905.1 - 8.3 6.6 26.7 0.084 13.1 10.2 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TolA_bind_tri PF16331.5 EAK88905.1 - 9.2 6.4 12.8 28 4.9 7.2 3.2 1 1 1 2 2 2 0 TolA binding protein trimerisation tRNA_U5-meth_tr PF05958.11 EAK88906.1 - 3.6e-10 39.4 2.3 3.3e-09 36.2 1.4 2.6 1 1 1 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EAK88906.1 - 1.3e-09 38.0 0.0 2.2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAK88906.1 - 1e-06 29.4 0.0 2.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EAK88906.1 - 3.5e-06 26.7 0.0 6.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EAK88906.1 - 4e-05 23.1 0.0 8.9e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EAK88906.1 - 0.00032 20.2 0.0 0.00077 19.0 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 EAK88906.1 - 0.00035 20.6 0.0 0.00072 19.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK88906.1 - 0.0018 19.0 0.0 0.0044 17.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK88906.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 EAK88906.1 - 0.057 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_15 PF09445.10 EAK88906.1 - 0.071 12.7 0.1 0.21 11.1 0.1 1.9 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 EAK88906.1 - 0.088 13.5 0.0 0.27 11.9 0.0 1.8 2 0 0 2 2 1 0 Methyltransferase domain Glutaredoxin PF00462.24 EAK88907.1 - 3.6e-13 49.5 0.1 5.3e-13 49.0 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin DNA_pol_E_B PF04042.16 EAK88908.1 - 4.8e-19 68.6 1.7 4.3e-18 65.4 1.7 2.2 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF2691 PF10903.8 EAK88908.1 - 0.0004 20.3 0.5 0.0015 18.4 0.5 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2691) DUF1647 PF07801.11 EAK88908.1 - 0.014 15.1 0.3 0.014 15.1 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) UPF0029 PF01205.19 EAK88909.1 - 1.5e-32 112.1 0.0 2.1e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EAK88909.1 - 0.027 14.8 0.2 0.059 13.7 0.2 1.5 1 0 0 1 1 1 0 RWD domain Ribosomal_L37e PF01907.19 EAK88910.1 - 6.5e-25 87.0 13.9 6.5e-25 87.0 13.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L37e SelR PF01641.18 EAK88910.1 - 0.0058 16.7 0.4 0.0062 16.6 0.4 1.2 1 0 0 1 1 1 1 SelR domain DZR PF12773.7 EAK88910.1 - 0.011 15.7 1.2 0.016 15.2 1.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 EAK88910.1 - 0.047 13.7 1.3 0.069 13.2 1.3 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-P11 PF03854.14 EAK88910.1 - 0.052 13.2 0.7 0.082 12.6 0.7 1.2 1 0 0 1 1 1 0 P-11 zinc finger Rubredoxin_2 PF18073.1 EAK88910.1 - 0.15 11.8 3.0 3.6 7.4 0.2 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-Mss51 PF13824.6 EAK88910.1 - 0.83 9.8 3.4 42 4.3 3.4 2.2 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DHHC PF01529.20 EAK88911.1 - 7.6e-33 113.5 19.7 7.6e-33 113.5 19.7 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase CTV_P6 PF06706.11 EAK88911.1 - 0.028 14.1 0.7 0.028 14.1 0.7 2.6 2 1 0 2 2 2 0 Citrus tristeza virus 6-kDa protein HMG_box PF00505.19 EAK88912.1 - 5.3e-21 74.8 2.0 5.3e-21 74.8 2.0 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EAK88912.1 - 1.2e-16 61.0 5.2 1.9e-16 60.4 5.2 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 EAK88912.1 - 0.00037 20.4 1.0 0.00037 20.4 1.0 1.8 1 1 1 2 2 2 1 HMG (high mobility group) box 5 Imm58 PF15581.6 EAK88912.1 - 0.032 14.3 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 58 Proteasome PF00227.26 EAK88913.1 - 1e-55 188.2 0.0 1.4e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EAK88913.1 - 1.5e-12 46.9 0.1 2.7e-12 46.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ArfGap PF01412.18 EAK88914.1 - 1.3e-38 131.6 0.7 1.3e-38 131.6 0.7 2.3 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf EF-hand_7 PF13499.6 EAK88915.1 - 1.4e-14 54.3 0.1 4.1e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAK88915.1 - 4.8e-14 50.8 0.4 1.6e-05 24.1 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EAK88915.1 - 9.2e-13 47.0 0.3 6.4e-05 22.6 0.8 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EAK88915.1 - 1.8e-10 39.9 0.5 0.00071 19.0 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EAK88915.1 - 1.4e-06 28.0 2.2 0.082 12.8 0.3 3.9 3 2 2 5 5 5 2 EF-hand domain pair Caleosin PF05042.13 EAK88915.1 - 0.00012 22.0 0.0 0.0047 16.9 0.0 2.1 2 0 0 2 2 2 1 Caleosin related protein EF-hand_14 PF17959.1 EAK88915.1 - 0.06 13.7 0.0 0.22 11.9 0.0 1.8 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 EAK88915.1 - 0.12 12.6 0.1 16 5.8 0.0 2.7 2 1 1 3 3 3 0 Dockerin type I domain DUF751 PF05421.11 EAK88916.1 - 0.016 15.9 3.5 2.4 8.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF751) AAA_22 PF13401.6 EAK88917.1 - 0.0026 18.0 0.1 0.0099 16.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EAK88917.1 - 0.0036 16.7 0.0 0.012 15.1 0.0 1.8 1 0 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 EAK88917.1 - 0.011 16.2 0.0 0.059 13.8 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 EAK88917.1 - 0.073 13.3 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF1971 PF09313.11 EAK88917.1 - 0.16 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) Proteasome PF00227.26 EAK88918.1 - 3.8e-56 189.6 0.0 5.4e-56 189.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EAK88918.1 - 3.1e-14 52.3 0.0 4.9e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature FAM83 PF07894.12 EAK88918.1 - 0.093 12.3 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 FAM83 A-H AAA PF00004.29 EAK88919.1 - 6.4e-42 143.1 0.0 1.7e-41 141.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EAK88919.1 - 1.6e-19 69.6 0.0 3.5e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EAK88919.1 - 8e-10 38.4 0.1 1.7e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EAK88919.1 - 3.7e-06 27.0 1.8 4.6e-05 23.4 0.1 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EAK88919.1 - 0.00012 21.9 0.0 0.0003 20.5 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EAK88919.1 - 0.00013 22.4 0.6 0.0046 17.3 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain TMF_TATA_bd PF12325.8 EAK88919.1 - 0.00038 20.7 2.6 0.00038 20.7 2.6 1.8 2 0 0 2 2 1 1 TATA element modulatory factor 1 TATA binding DUF1192 PF06698.11 EAK88919.1 - 0.00046 20.2 0.2 0.0014 18.6 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) AAA_2 PF07724.14 EAK88919.1 - 0.00091 19.4 0.0 0.0047 17.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EAK88919.1 - 0.00094 19.5 1.1 0.096 13.0 0.1 2.5 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EAK88919.1 - 0.0024 17.3 0.2 0.013 14.9 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI UPF0242 PF06785.11 EAK88919.1 - 0.0033 17.5 0.8 0.0057 16.8 0.8 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus AAA_33 PF13671.6 EAK88919.1 - 0.0046 17.1 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain TolA_bind_tri PF16331.5 EAK88919.1 - 0.0058 16.7 3.5 0.011 15.8 1.1 2.3 2 0 0 2 2 2 1 TolA binding protein trimerisation DUF815 PF05673.13 EAK88919.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) KELK PF15796.5 EAK88919.1 - 0.013 16.0 2.0 0.035 14.6 2.0 1.8 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PhoH PF02562.16 EAK88919.1 - 0.015 14.8 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.17 EAK88919.1 - 0.027 14.2 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF1640 PF07798.11 EAK88919.1 - 0.029 14.4 1.0 0.054 13.5 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) AAA_11 PF13086.6 EAK88919.1 - 0.03 14.1 0.2 0.73 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EAK88919.1 - 0.041 13.6 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EAK88919.1 - 0.07 12.8 0.0 0.29 10.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 EAK88919.1 - 0.089 12.1 0.5 0.23 10.8 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 EAK88919.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region ZapB PF06005.12 EAK88919.1 - 0.42 11.1 5.9 0.32 11.5 3.2 2.1 2 0 0 2 2 2 0 Cell division protein ZapB MCM PF00493.23 EAK88920.1 - 2e-94 314.9 0.1 2.2e-82 275.5 0.0 2.6 3 0 0 3 3 3 2 MCM P-loop domain MCM_OB PF17207.3 EAK88920.1 - 9.2e-34 116.0 0.3 2.2e-33 114.8 0.3 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EAK88920.1 - 1.3e-28 99.2 0.3 3e-28 98.1 0.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EAK88920.1 - 4.7e-06 26.1 0.0 0.00014 21.3 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EAK88920.1 - 7.1e-06 26.6 0.0 0.0001 22.8 0.0 2.8 1 1 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 EAK88920.1 - 2.5e-05 24.3 0.0 0.0001 22.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EAK88920.1 - 0.0046 16.8 0.0 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 EAK88920.1 - 0.0075 16.9 0.3 0.17 12.6 0.1 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal AAA_16 PF13191.6 EAK88920.1 - 0.015 15.7 0.1 1.5 9.2 0.0 2.5 1 1 1 2 2 2 0 AAA ATPase domain EF-hand_4 PF12763.7 EAK88921.1 - 2.9e-12 46.5 2.0 4.9e-06 26.5 0.4 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EAK88921.1 - 2.6e-07 29.7 5.4 0.033 13.7 0.6 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EAK88921.1 - 1.3e-05 25.5 9.7 0.00035 21.0 1.1 3.7 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 EAK88921.1 - 0.00013 21.6 4.3 1.3 9.1 0.2 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EAK88921.1 - 0.0013 18.6 2.9 1.1 9.2 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair TMF_TATA_bd PF12325.8 EAK88921.1 - 0.018 15.3 5.1 0.037 14.3 5.1 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding EF-hand_5 PF13202.6 EAK88921.1 - 0.021 14.3 0.7 0.29 10.7 0.1 2.6 2 0 0 2 2 2 0 EF hand DUF2087 PF09860.9 EAK88921.1 - 0.15 12.3 0.0 0.55 10.4 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) CBM77 PF18283.1 EAK88921.1 - 0.26 11.7 1.7 1.3 9.4 0.1 2.7 2 1 1 3 3 3 0 Carbohydrate binding module 77 RNA_pol_Rpb5_C PF01191.19 EAK88922.1 - 2.7e-34 116.9 0.3 4.8e-34 116.1 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EAK88922.1 - 6e-22 78.0 2.2 9.4e-22 77.4 2.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EAK88922.1 - 0.0071 16.4 0.3 0.016 15.2 0.3 1.7 1 1 0 1 1 1 1 Restriction endonuclease Peptidase_M16 PF00675.20 EAK88923.1 - 2.2e-33 115.4 2.0 4.6e-33 114.3 0.3 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EAK88923.1 - 7.1e-25 87.9 7.8 7.1e-25 87.9 7.8 2.5 2 1 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EAK88923.1 - 3.3e-16 59.8 0.1 7.1e-14 52.2 0.0 2.9 2 0 0 2 2 2 2 Peptidase M16 inactive domain Cpn60_TCP1 PF00118.24 EAK88924.1 - 9.9e-146 486.2 4.7 1.1e-145 486.0 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF4995 PF16386.5 EAK88924.1 - 0.15 12.0 0.0 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function Proteasome PF00227.26 EAK88925.1 - 1.4e-47 161.7 0.4 1.9e-47 161.2 0.4 1.2 1 0 0 1 1 1 1 Proteasome subunit PIG-P PF08510.12 EAK88926.1 - 3.3e-25 88.3 0.1 1.9e-24 85.9 0.1 1.9 1 1 0 1 1 1 1 PIG-P DPM2 PF07297.12 EAK88926.1 - 0.13 12.6 2.4 0.23 11.8 2.4 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) SNAP PF14938.6 EAK88927.1 - 2.9e-61 207.4 16.0 2.4e-58 197.8 16.0 2.8 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EAK88927.1 - 0.00012 22.3 6.0 0.047 14.0 0.0 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat Sel1 PF08238.12 EAK88927.1 - 0.00016 22.3 1.6 32 5.4 0.0 5.2 5 0 0 5 5 5 0 Sel1 repeat TPR_2 PF07719.17 EAK88927.1 - 0.00041 20.2 15.2 0.48 10.7 0.3 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EAK88927.1 - 0.18 11.9 7.5 53 4.2 0.0 5.5 4 1 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EAK88927.1 - 0.23 11.3 17.3 0.26 11.2 0.1 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 EAK88927.1 - 0.29 11.2 15.3 1.8 8.7 0.1 5.3 4 2 1 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 EAK88927.1 - 1.1 9.7 0.1 1.1 9.7 0.1 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat NSF PF02071.20 EAK88927.1 - 2.1 9.5 9.5 74 4.8 0.2 6.2 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat MutL_C PF08676.11 EAK88928.1 - 2.6e-18 66.2 2.9 1.8e-17 63.4 0.3 2.8 3 0 0 3 3 3 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EAK88928.1 - 7.5e-16 57.9 1.4 1e-15 57.4 0.1 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EAK88928.1 - 6.7e-08 32.4 0.6 6.7e-08 32.4 0.6 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EAK88928.1 - 8.3e-07 29.5 0.8 3.8e-06 27.4 0.7 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EAK88928.1 - 0.021 14.8 0.0 0.052 13.5 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HIT PF01230.23 EAK88928.1 - 0.088 13.6 0.5 0.32 11.8 0.5 1.9 1 0 0 1 1 1 0 HIT domain RNA_pol_Rpc4 PF05132.14 EAK88928.1 - 7.7 6.9 17.5 3.1 8.2 6.6 3.3 3 0 0 3 3 3 0 RNA polymerase III RPC4 Sec61_beta PF03911.16 EAK88929.1 - 5.5e-15 55.1 0.3 6.7e-15 54.8 0.3 1.1 1 0 0 1 1 1 1 Sec61beta family Nuc_sug_transp PF04142.15 EAK88930.1 - 1.1e-103 346.7 22.3 1.3e-103 346.4 22.3 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EAK88930.1 - 4.7e-05 22.7 13.7 4.9e-05 22.7 9.6 2.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EAK88930.1 - 6.8e-05 23.1 34.6 0.00041 20.5 7.8 2.7 2 1 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 EAK88930.1 - 0.017 14.4 15.5 0.0091 15.3 12.2 2.1 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport RED_C PF07807.11 EAK88930.1 - 0.19 12.2 1.0 0.37 11.3 1.0 1.4 1 0 0 1 1 1 0 RED-like protein C-terminal region TMEM234 PF10639.9 EAK88930.1 - 9.6 6.3 18.0 1.5 8.9 1.3 3.3 2 1 0 3 3 3 0 Putative transmembrane family 234 PQ-loop PF04193.14 EAK88931.1 - 1.4e-20 72.8 20.8 1.8e-11 43.6 8.8 2.8 2 1 0 2 2 2 2 PQ loop repeat Proteasome PF00227.26 EAK88932.1 - 3.9e-39 134.1 0.0 4.5e-39 133.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Mito_carr PF00153.27 EAK88933.1 - 3.2e-31 107.1 2.2 1.6e-15 56.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 EAK88934.1 - 2.4e-23 81.7 0.0 5.7e-17 61.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EAK88934.1 - 5.6e-06 26.3 0.1 0.1 12.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EAK88934.1 - 0.00091 19.1 0.0 0.89 9.6 0.0 2.7 1 1 1 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EAK88934.1 - 0.0022 18.1 0.1 0.012 15.7 0.0 2.2 2 1 0 2 2 2 1 RNA recognition motif RL PF17797.1 EAK88934.1 - 0.091 12.7 0.1 5.2 7.1 0.1 2.3 2 0 0 2 2 2 0 RL domain NID PF07292.13 EAK88934.1 - 0.15 12.7 0.0 6.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) Arm PF00514.23 EAK88935.1 - 0.004 17.2 0.3 6.2 7.0 0.0 3.1 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 EAK88935.1 - 0.0094 16.0 0.2 0.85 9.7 0.0 3.1 2 1 1 3 3 3 2 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 EAK88935.1 - 0.16 12.0 1.6 0.56 10.2 0.2 2.4 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DnaJ_C PF01556.18 EAK88936.1 - 5.8e-24 84.9 0.0 9.5e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EAK88936.1 - 4e-20 71.7 2.8 5e-20 71.4 1.4 1.9 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EAK88936.1 - 1.1e-08 35.3 6.2 5.2e-08 33.1 6.2 2.2 1 1 0 1 1 1 1 DnaJ central domain DUF4248 PF14053.6 EAK88936.1 - 0.019 15.0 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) Anti-TRAP PF15777.5 EAK88936.1 - 0.027 14.4 13.0 0.058 13.4 3.3 2.9 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EAK88936.1 - 2.3 8.3 5.7 0.96 9.5 1.3 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ZPR1 PF03367.13 EAK88937.1 - 1.1e-102 340.6 4.1 5.4e-54 182.4 0.5 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EAK88937.1 - 0.0095 15.9 2.8 0.26 11.3 0.1 2.6 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 EAK88937.1 - 0.089 12.8 6.5 3.9 7.5 0.3 3.5 4 0 0 4 4 4 0 Transposase zinc-ribbon domain CpXC PF14353.6 EAK88937.1 - 0.42 10.7 3.6 16 5.5 0.6 3.5 3 1 0 3 3 3 0 CpXC protein DUF3797 PF12677.7 EAK88937.1 - 0.76 9.7 4.5 4.4 7.3 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) OrfB_Zn_ribbon PF07282.11 EAK88937.1 - 0.93 9.5 3.9 6.3 6.8 0.0 3.1 2 1 1 3 3 3 0 Putative transposase DNA-binding domain zf-Sec23_Sec24 PF04810.15 EAK88937.1 - 1 9.4 4.0 4.8 7.3 0.5 2.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger RecR PF02132.15 EAK88937.1 - 2.1 8.0 6.2 0.21 11.2 0.7 2.2 2 0 0 2 2 2 0 RecR protein DUF1610 PF07754.11 EAK88937.1 - 4.3 7.4 10.7 6.7 6.8 3.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-ribbon_3 PF13248.6 EAK88937.1 - 7.9 6.0 15.7 4.6 6.8 3.5 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Eco57I PF07669.11 EAK88938.1 - 0.011 16.3 0.6 0.33 11.5 0.0 2.9 3 0 0 3 3 3 0 Eco57I restriction-modification methylase RE_HaeIII PF09556.10 EAK88938.1 - 0.03 13.4 2.2 0.03 13.4 0.1 1.9 2 0 0 2 2 2 0 HaeIII restriction endonuclease Aa_trans PF01490.18 EAK88939.1 - 4.2e-42 144.3 32.3 6.3e-42 143.7 32.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EAK88939.1 - 5.2e-05 22.5 15.9 5.2e-05 22.5 15.9 2.7 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family DUF3681 PF12442.8 EAK88939.1 - 2.2 8.8 7.2 15 6.1 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3681) WEMBL PF05701.11 EAK88941.1 - 0.00027 19.8 5.4 0.00046 19.0 5.4 1.4 1 1 0 1 1 1 1 Weak chloroplast movement under blue light HIP1_clath_bdg PF16515.5 EAK88941.1 - 0.0015 19.1 2.4 0.0043 17.6 0.1 2.3 2 1 0 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Tweety PF04906.13 EAK88941.1 - 0.0043 15.8 1.4 0.0043 15.8 1.4 1.6 1 1 0 1 1 1 1 Tweety V-SNARE_C PF12352.8 EAK88941.1 - 0.013 15.8 0.8 0.045 14.0 0.6 2.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus MHC_II_beta PF00969.19 EAK88941.1 - 0.017 15.2 1.6 0.22 11.6 0.2 2.7 3 0 0 3 3 3 0 Class II histocompatibility antigen, beta domain Paramyx_P_V_C PF03210.13 EAK88941.1 - 0.049 13.4 1.6 0.066 13.0 0.3 1.8 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal V-ATPase_C PF03223.15 EAK88941.1 - 0.084 12.3 5.3 0.33 10.3 5.3 1.9 1 1 0 1 1 1 0 V-ATPase subunit C Syntaxin-6_N PF09177.11 EAK88941.1 - 0.15 12.7 7.5 0.87 10.2 1.5 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal ABC2_membrane_3 PF12698.7 EAK88941.1 - 0.16 11.0 3.1 0.23 10.5 3.1 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF745 PF05335.13 EAK88941.1 - 0.18 11.5 0.5 0.35 10.6 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF745) FlaC_arch PF05377.11 EAK88941.1 - 0.23 11.9 0.3 0.23 11.9 0.3 3.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 EAK88941.1 - 0.31 11.5 11.4 0.12 12.9 5.8 2.5 1 1 2 3 3 3 0 Protein of unknown function DUF16 Sec20 PF03908.13 EAK88941.1 - 0.9 9.5 9.5 0.037 13.9 1.6 2.5 2 1 0 3 3 3 0 Sec20 DUF1664 PF07889.12 EAK88941.1 - 2.8 8.0 6.2 7.1 6.7 2.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DNA_pol_B PF00136.21 EAK88942.1 - 1.5e-106 356.9 0.3 2.4e-106 356.2 0.3 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EAK88942.1 - 2e-24 86.4 1.6 1.4e-23 83.6 1.6 2.3 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EAK88942.1 - 9e-17 60.9 5.0 9e-17 60.9 5.0 2.7 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal zf-DNA_Pol PF08996.10 EAK88942.1 - 4.6e-05 23.2 2.6 0.0001 22.1 2.6 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger RRM_DME PF15628.6 EAK88942.1 - 0.19 11.9 0.2 4.4 7.5 0.1 2.5 2 0 0 2 2 2 0 RRM in Demeter Peptidase_M16_M PF16187.5 EAK88943.1 - 9.6e-11 41.5 8.5 7.2e-06 25.5 0.2 4.1 4 0 0 4 4 4 2 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EAK88943.1 - 3.9e-09 36.6 0.0 1.4e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88943.1 - 6.1e-09 36.2 0.1 4.8e-08 33.2 0.1 2.5 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK88945.1 - 3.3e-30 105.0 0.4 7.6e-30 103.9 0.4 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88945.1 - 2.5e-15 57.0 10.8 6.5e-09 36.1 0.3 3.7 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16_M PF16187.5 EAK88945.1 - 1.1e-10 41.3 22.7 1.7e-08 34.1 16.4 3.6 2 1 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EAK88946.1 - 1.4e-25 90.0 0.1 3.9e-25 88.6 0.1 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EAK88946.1 - 1.1e-13 51.2 21.3 1.1e-09 38.1 15.6 3.9 2 1 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EAK88946.1 - 6.6e-10 39.3 9.0 1.6e-09 38.1 0.2 3.7 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK88947.1 - 3.4e-08 33.6 0.0 3.4e-08 33.6 0.0 2.6 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88947.1 - 6.3e-08 32.8 1.1 0.0015 18.6 0.6 3.3 2 1 0 2 2 2 2 Peptidase M16 inactive domain Pex26 PF07163.12 EAK88947.1 - 0.038 13.3 0.1 1.3 8.3 0.0 3.1 4 0 0 4 4 4 0 Pex26 protein Il13Ra_Ig PF18001.1 EAK88948.1 - 0.18 11.9 0.7 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 Interleukin-13 receptor subunit alpha Ig-like domain Peptidase_M16 PF00675.20 EAK88949.1 - 2.3e-10 40.6 0.1 7.1e-10 39.1 0.1 1.9 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88949.1 - 1.8e-09 37.8 0.4 1.5e-08 34.9 0.0 2.7 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16_C PF05193.21 EAK88950.1 - 3.5e-10 40.2 0.1 8e-08 32.5 0.2 2.6 2 1 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK88950.1 - 7.4e-06 26.0 0.1 3.5e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88951.1 - 9.9e-09 35.5 0.1 9.9e-09 35.5 0.1 2.3 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK88951.1 - 6.3e-06 26.2 0.0 2.4e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK88952.1 - 5.2e-15 55.9 1.5 5.9e-12 46.0 0.0 3.4 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK88952.1 - 3.2e-13 49.9 0.1 1e-12 48.2 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) zf-CCHC PF00098.23 EAK88953.1 - 1.5e-11 43.8 24.9 0.00023 21.1 0.2 4.3 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 EAK88953.1 - 0.0013 18.4 25.9 0.042 13.6 0.8 4.7 4 0 0 4 4 4 3 Zinc knuckle HTH_38 PF13936.6 EAK88953.1 - 0.043 13.6 1.5 0.1 12.4 1.5 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Desulfoferrod_N PF06397.12 EAK88953.1 - 0.16 11.6 3.8 1.1 8.9 0.1 3.1 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain DUF489 PF04356.12 EAK88953.1 - 0.57 10.2 6.1 0.14 12.1 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF489) zf-CCHC_2 PF13696.6 EAK88953.1 - 1 9.3 26.4 0.55 10.1 1.2 4.3 4 0 0 4 4 4 0 Zinc knuckle Pro-MCH PF05824.12 EAK88953.1 - 1.1 9.2 6.0 4 7.4 0.0 3.5 4 0 0 4 4 4 0 Pro-melanin-concentrating hormone (Pro-MCH) SpoVR PF04293.13 EAK88953.1 - 4.9 5.7 11.7 10 4.7 11.7 1.5 1 0 0 1 1 1 0 SpoVR like protein E1-E2_ATPase PF00122.20 EAK88954.1 - 1.1e-21 77.2 0.8 3.5e-19 69.0 0.0 4.1 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EAK88954.1 - 3.1e-08 33.6 0.0 7e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EAK88954.1 - 4e-06 27.3 0.2 0.03 14.6 0.2 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EAK88954.1 - 0.0071 16.0 0.1 0.028 14.1 0.1 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus BTRD1 PF17660.1 EAK88954.1 - 0.066 13.0 0.1 0.29 11.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 Prismane PF03063.20 EAK88954.1 - 0.15 10.7 0.4 0.75 8.4 0.0 2.0 2 0 0 2 2 2 0 Prismane/CO dehydrogenase family Hira PF07569.11 EAK88956.1 - 4 7.1 27.1 0.024 14.4 7.9 4.5 3 2 0 3 3 3 0 TUP1-like enhancer of split TFIID_30kDa PF03540.13 EAK88957.1 - 7.1e-08 32.3 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit RNA_pol_Rpb1_4 PF05000.17 EAK88957.1 - 0.011 15.6 0.0 0.017 15.1 0.0 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 4 Ribosomal_S8e PF01201.22 EAK88959.1 - 2.2e-51 173.6 5.4 9.5e-51 171.6 0.5 2.0 1 1 1 2 2 2 2 Ribosomal protein S8e zf-UBR PF02207.20 EAK88960.1 - 3.7e-18 65.4 17.7 3.7e-18 65.4 17.7 2.4 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) RGS PF00615.19 EAK88960.1 - 0.071 13.4 5.0 0.19 12.0 1.5 3.7 3 0 0 3 3 3 0 Regulator of G protein signaling domain Ribosomal_L21e PF01157.18 EAK88961.1 - 0.14 12.0 0.5 0.21 11.4 0.5 1.2 1 0 0 1 1 1 0 Ribosomal protein L21e Trypan_PARP PF05887.11 EAK88962.1 - 5.3e-07 29.7 77.7 0.00045 20.2 37.1 3.2 2 1 1 3 3 3 2 Procyclic acidic repetitive protein (PARP) Reprolysin_4 PF13583.6 EAK88962.1 - 8.3 6.0 10.1 0.73 9.4 4.9 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like HECT_2 PF09814.9 EAK88963.1 - 1.2e-06 27.6 6.2 1.7e-06 27.1 6.2 1.2 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Yippee-Mis18 PF03226.14 EAK88963.1 - 0.00015 21.9 1.4 0.0021 18.3 0.5 3.0 2 1 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 EAK88963.1 - 0.0023 17.9 2.2 0.075 13.1 0.4 2.4 2 0 0 2 2 2 1 Double zinc ribbon DNA_RNApol_7kD PF03604.13 EAK88963.1 - 0.23 11.1 1.0 5.7 6.7 0.0 3.0 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-ribbon_3 PF13248.6 EAK88963.1 - 6.8 6.2 6.4 15 5.1 0.2 3.2 3 0 0 3 3 3 0 zinc-ribbon domain CS PF04969.16 EAK88964.1 - 1.9e-12 48.0 4.3 3.3e-12 47.2 4.3 1.4 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.11 EAK88964.1 - 0.00023 21.4 0.4 0.00054 20.2 0.4 1.8 1 0 0 1 1 1 1 Siah interacting protein, N terminal SGS PF05002.15 EAK88964.1 - 0.00075 19.6 0.2 0.0018 18.4 0.2 1.7 1 0 0 1 1 1 1 SGS domain Pre-PUA PF17832.1 EAK88966.1 - 2e-27 95.7 0.2 3.6e-27 94.9 0.2 1.4 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EAK88966.1 - 1.4e-18 66.6 0.1 1.9e-18 66.2 0.1 1.2 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 EAK88966.1 - 0.012 15.9 0.1 0.024 14.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) PUB PF09409.10 EAK88967.1 - 6.9e-25 86.8 0.8 8.6e-24 83.3 0.1 2.5 2 0 0 2 2 2 1 PUB domain UBA PF00627.31 EAK88967.1 - 4.7e-05 23.2 0.1 0.00037 20.3 0.0 2.4 2 0 0 2 2 2 1 UBA/TS-N domain BBP1_N PF15271.6 EAK88968.1 - 0.0048 17.7 2.4 0.0048 17.7 2.4 2.0 2 0 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein Piezo_RRas_bdg PF12166.8 EAK88968.1 - 0.085 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain OppC_N PF12911.7 EAK88968.1 - 0.22 11.6 0.3 0.38 10.8 0.3 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C RseA_C PF03873.13 EAK88969.1 - 4.6e-14 52.4 24.0 0.8 10.0 0.0 16.1 6 6 11 17 17 17 7 Anti sigma-E protein RseA, C-terminal domain GTP_EFTU PF00009.27 EAK88970.1 - 1.4e-35 122.6 0.0 7.2e-35 120.3 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EAK88970.1 - 5e-35 120.7 16.6 9.2e-35 119.9 16.6 1.5 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EAK88970.1 - 1.9e-20 72.9 0.0 4.5e-20 71.6 0.0 1.7 1 1 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EAK88970.1 - 6.8e-18 64.5 0.0 1.3e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EAK88970.1 - 6.2e-06 26.2 0.0 1.9e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EAK88970.1 - 3.2e-05 24.2 0.0 7.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EAK88970.1 - 0.0015 18.6 0.0 0.0032 17.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EAK88970.1 - 0.02 14.2 1.1 0.03 13.6 0.0 1.8 2 0 0 2 2 2 0 Septin Roc PF08477.13 EAK88970.1 - 0.073 13.3 0.0 4.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PUB PF09409.10 EAK88971.1 - 1e-14 54.2 2.0 3.9e-14 52.3 2.0 2.1 1 0 0 1 1 1 1 PUB domain DSPc PF00782.20 EAK88971.1 - 0.065 13.1 0.1 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain DNA_ligase_A_M PF01068.21 EAK88972.1 - 2.6e-57 193.8 0.6 5.1e-57 192.8 0.6 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EAK88972.1 - 2e-34 119.4 0.3 4.8e-34 118.2 0.3 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EAK88972.1 - 2.2e-24 85.9 0.0 5.3e-24 84.7 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EAK88972.1 - 1.4e-06 28.7 0.1 3e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 EAK88972.1 - 0.098 12.5 2.3 0.49 10.2 0.6 2.6 2 1 0 2 2 2 0 mRNA capping enzyme, catalytic domain DNA_ligase_OB_2 PF14743.6 EAK88972.1 - 0.15 12.1 0.4 24 5.1 0.0 3.1 3 0 0 3 3 3 0 DNA ligase OB-like domain WD40 PF00400.32 EAK88973.1 - 0.0023 18.7 10.2 0.014 16.3 1.1 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF1523 PF07509.11 EAK88973.1 - 0.028 13.8 0.0 0.068 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) AAA PF00004.29 EAK88974.1 - 7e-11 42.7 5.2 3.6e-06 27.4 0.3 3.1 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) EzrA PF06160.12 EAK88975.1 - 0.0014 16.9 4.0 0.0028 15.9 4.0 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA zf-CpG_bind_C PF12269.8 EAK88975.1 - 0.013 15.3 0.6 0.026 14.3 0.6 1.5 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain CCDC-167 PF15188.6 EAK88975.1 - 0.035 14.4 1.7 0.1 12.9 1.7 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 V-ATPase_C PF03223.15 EAK88975.1 - 0.055 12.9 0.3 0.11 11.9 0.3 1.5 1 0 0 1 1 1 0 V-ATPase subunit C ERM PF00769.19 EAK88975.1 - 0.12 12.2 3.0 0.16 11.8 0.8 1.9 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Fzo_mitofusin PF04799.13 EAK88975.1 - 0.24 10.9 3.4 11 5.6 0.1 2.3 2 0 0 2 2 2 0 fzo-like conserved region DUF5094 PF17015.5 EAK88975.1 - 0.44 10.6 6.9 1.2 9.2 6.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Siva PF05458.12 EAK88976.1 - 3.7e-07 30.0 9.8 4.4e-07 29.7 9.8 1.1 1 0 0 1 1 1 1 Cd27 binding protein (Siva) Ctf8 PF09696.10 EAK88977.1 - 0.0045 17.3 0.1 0.0072 16.7 0.1 1.3 1 1 0 1 1 1 1 Ctf8 Peptidase_S49_N PF08496.10 EAK88978.1 - 3.5 7.7 6.5 0.66 10.0 2.5 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF773 PF05600.12 EAK88979.1 - 7.3e-14 51.4 28.5 4.6e-11 42.1 9.6 2.1 1 1 1 2 2 2 2 CDK5 regulatory subunit-associated protein 3 GFP PF01353.22 EAK88979.1 - 0.0067 15.9 0.7 0.015 14.8 0.7 1.5 1 0 0 1 1 1 1 Green fluorescent protein Exonuc_VII_L PF02601.15 EAK88979.1 - 0.25 10.9 9.6 1.3 8.5 0.8 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Rootletin PF15035.6 EAK88979.1 - 0.67 9.9 12.5 0.096 12.7 3.6 2.7 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion FliJ PF02050.16 EAK88979.1 - 0.73 10.1 9.1 0.16 12.2 4.0 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein DUF4094 PF13334.6 EAK88979.1 - 3.8 8.0 5.9 5.6 7.5 0.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Jnk-SapK_ap_N PF09744.9 EAK88979.1 - 6.2 7.0 15.9 1.9 8.7 2.2 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 CK_II_beta PF01214.18 EAK88980.1 - 1.9e-69 233.1 0.1 2.4e-69 232.8 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit BicD PF09730.9 EAK88982.1 - 1.2 7.4 7.2 0.071 11.5 1.3 1.9 2 1 0 2 2 2 0 Microtubule-associated protein Bicaudal-D 2OG-FeII_Oxy_3 PF13640.6 EAK88983.1 - 1.1e-06 29.5 0.1 2.3e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_S51 PF03575.17 EAK88983.1 - 0.2 11.2 1.3 2.3 7.8 0.1 2.3 2 0 0 2 2 2 0 Peptidase family S51 CorA PF01544.18 EAK88985.1 - 0.46 9.7 18.6 0.065 12.5 5.9 3.1 3 1 0 3 3 3 0 CorA-like Mg2+ transporter protein MMR_HSR1_Xtn PF16897.5 EAK88986.1 - 6.2e-43 145.1 1.0 9.9e-43 144.5 1.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EAK88986.1 - 7.4e-22 77.2 0.1 1.3e-21 76.3 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EAK88986.1 - 7.3e-21 74.4 0.0 2e-20 73.0 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAK88986.1 - 2.9e-11 43.2 0.1 9.7e-11 41.4 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EAK88986.1 - 0.00077 18.5 0.3 0.0024 16.9 0.1 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EAK88986.1 - 0.00078 19.5 0.1 0.98 9.5 0.2 2.4 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 EAK88986.1 - 0.086 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EAK88986.1 - 0.11 12.5 0.1 0.91 9.4 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase SAC3_GANP PF03399.16 EAK88987.1 - 1.2e-27 97.0 5.6 3.9e-26 92.1 5.6 2.4 1 1 0 1 1 1 1 SAC3/GANP family DUF4973 PF16343.5 EAK88988.1 - 0.028 14.5 0.6 0.059 13.4 0.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4973) Na_Ca_ex PF01699.24 EAK88989.1 - 8.6e-34 116.7 49.4 8.4e-21 74.5 15.3 3.3 3 0 0 3 3 3 2 Sodium/calcium exchanger protein FAM53 PF15242.6 EAK88989.1 - 0.34 10.7 7.0 0.61 9.9 7.0 1.3 1 0 0 1 1 1 0 Family of FAM53 RRM_1 PF00076.22 EAK88991.1 - 2.5e-12 46.4 2.4 1.6e-09 37.5 0.1 4.3 3 2 1 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK88991.1 - 0.0011 19.1 0.0 0.039 14.1 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif BRAP2 PF07576.12 EAK88991.1 - 0.062 13.5 0.0 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 BRCA1-associated protein 2 Sec7 PF01369.20 EAK88993.1 - 4.2e-48 163.5 5.9 4.2e-48 163.5 5.9 4.8 6 0 0 6 6 6 1 Sec7 domain DWNN PF08783.11 EAK88995.1 - 2.8e-12 46.7 0.1 2.8e-12 46.7 0.1 2.6 3 0 0 3 3 3 1 DWNN domain zf-RING_2 PF13639.6 EAK88995.1 - 0.039 14.3 6.0 0.079 13.3 6.0 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 EAK88995.1 - 0.37 10.7 6.0 0.61 10.0 6.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EAK88995.1 - 0.62 10.3 9.3 0.53 10.5 6.8 2.2 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EAK88995.1 - 0.67 9.8 3.8 1.4 8.8 3.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 EAK88995.1 - 0.91 9.4 8.0 2.2 8.2 8.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK88995.1 - 1.3 9.0 7.5 2.4 8.1 7.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK88995.1 - 5.9 6.9 6.7 12 6.0 6.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain PCNA_N PF00705.18 EAK88996.1 - 8.3e-39 132.2 4.4 1.3e-38 131.6 4.4 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EAK88996.1 - 1e-32 113.0 0.0 3.6e-29 101.5 0.0 2.2 2 0 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EAK88996.1 - 1.9e-09 37.0 1.1 1.3e-07 31.0 0.4 2.0 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EAK88996.1 - 3.3e-07 30.0 0.1 5.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Rad9 DNA_pol3_beta_2 PF02767.16 EAK88996.1 - 0.0082 16.4 0.0 0.21 11.8 0.0 2.3 1 1 1 2 2 2 1 DNA polymerase III beta subunit, central domain Hus1 PF04005.12 EAK88996.1 - 0.076 12.1 0.2 0.49 9.5 0.1 2.2 1 1 2 3 3 3 0 Hus1-like protein HSP70 PF00012.20 EAK88997.1 - 5.7e-261 866.9 9.6 6.5e-261 866.8 9.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EAK88997.1 - 4.3e-15 55.4 1.6 2.1e-13 49.8 0.5 2.6 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EAK88997.1 - 0.0074 16.0 0.0 0.041 13.6 0.0 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain GLE1 PF07817.13 EAK88997.1 - 0.015 14.5 2.8 6.3 5.9 0.0 2.3 2 0 0 2 2 2 0 GLE1-like protein Syntaxin-6_N PF09177.11 EAK88997.1 - 0.57 10.8 6.5 8.3 7.0 0.3 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Z1 PF10593.9 EAK88997.1 - 4.1 6.8 7.2 8.7 5.8 7.2 1.6 1 0 0 1 1 1 0 Z1 domain Cu_amine_oxid PF01179.20 EAK88998.1 - 9.9e-66 222.3 0.1 1.5e-65 221.7 0.1 1.3 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain MAM PF00629.23 EAK88998.1 - 1.1e-14 54.6 0.0 3.2e-14 53.2 0.0 1.8 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu EF-hand_7 PF13499.6 EAK88999.1 - 2.1e-10 40.9 2.4 5.4e-10 39.6 2.4 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EAK88999.1 - 9.5e-10 37.3 6.3 7.3e-05 22.0 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EAK88999.1 - 4.3e-09 35.6 5.1 0.0001 22.0 0.4 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EAK88999.1 - 1.2e-07 31.5 5.9 0.0019 18.0 1.0 3.0 2 1 1 3 3 3 2 EF-hand domain pair COPI_assoc PF08507.10 EAK88999.1 - 0.00012 22.1 14.5 0.00019 21.5 14.5 1.3 1 0 0 1 1 1 1 COPI associated protein EF-hand_5 PF13202.6 EAK88999.1 - 0.00026 20.3 7.6 0.034 13.6 0.4 3.6 3 0 0 3 3 3 2 EF hand Cg6151-P PF10233.9 EAK88999.1 - 2 8.7 10.4 3.2 8.1 10.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein CG6151-P Adeno_E1B_19K PF01691.16 EAK89000.1 - 0.013 15.0 0.8 0.049 13.2 0.2 2.3 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen RNA_ligase PF09414.10 EAK89000.1 - 0.066 13.5 0.0 0.19 12.1 0.0 1.9 1 1 0 1 1 1 0 RNA ligase AAA_14 PF13173.6 EAK89000.1 - 0.069 13.2 1.0 1.8 8.6 0.0 3.7 3 0 0 3 3 3 0 AAA domain RPAP1_C PF08620.10 EAK89001.1 - 2e-23 82.3 0.0 5.6e-23 80.8 0.0 1.8 1 0 0 1 1 1 1 RPAP1-like, C-terminal Sigma70_r1_2 PF00140.20 EAK89001.1 - 0.035 14.1 0.1 0.075 13.1 0.1 1.6 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 Diphthamide_syn PF01866.17 EAK89003.1 - 2.8e-19 69.7 4.3 2.2e-09 37.2 1.6 2.5 2 1 0 2 2 2 2 Putative diphthamide synthesis protein STAT2_C PF12188.8 EAK89003.1 - 0.086 12.8 0.2 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal ITI_HC_C PF06668.12 EAK89004.1 - 0.043 13.5 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Inter-alpha-trypsin inhibitor heavy chain C-terminus T-box PF00907.22 EAK89004.1 - 0.1 12.9 1.0 0.2 11.9 0.1 1.9 2 0 0 2 2 2 0 T-box Ribosomal_L7Ae PF01248.26 EAK89005.1 - 1.4e-07 31.1 0.0 2.9e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family UPF0242 PF06785.11 EAK89007.1 - 0.011 15.9 16.8 0.011 15.9 16.8 4.4 2 2 1 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus CENP-H PF05837.12 EAK89007.1 - 0.012 16.1 4.1 0.012 16.1 4.1 5.4 3 1 2 5 5 5 0 Centromere protein H (CENP-H) DUF948 PF06103.11 EAK89007.1 - 0.46 10.8 12.6 4.2 7.7 1.3 4.1 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Caldesmon PF02029.15 EAK89007.1 - 1.3 7.7 58.5 0.23 10.2 53.8 1.9 1 1 1 2 2 2 0 Caldesmon Med31 PF05669.12 EAK89008.1 - 6.1e-36 122.3 5.8 7.2e-36 122.1 5.8 1.0 1 0 0 1 1 1 1 SOH1 Med4 PF10018.9 EAK89009.1 - 0.077 12.7 0.1 0.084 12.5 0.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 AAA_18 PF13238.6 EAK89010.1 - 3.1e-27 95.7 0.3 4.3e-27 95.2 0.3 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EAK89010.1 - 7.4e-07 29.4 0.0 1.8e-06 28.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EAK89010.1 - 5.2e-05 22.8 0.0 8.1e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_5 PF07728.14 EAK89010.1 - 8.4e-05 22.6 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EAK89010.1 - 0.00014 22.2 0.1 0.00025 21.3 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EAK89010.1 - 0.00015 22.2 0.4 0.00039 20.8 0.1 1.8 2 1 0 2 2 1 1 AAA domain AAA_22 PF13401.6 EAK89010.1 - 0.00017 21.9 0.2 0.00027 21.2 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EAK89010.1 - 0.00042 20.8 0.0 0.00059 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EAK89010.1 - 0.0011 18.7 1.0 0.0034 17.1 0.4 2.0 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 EAK89010.1 - 0.0011 19.3 1.3 0.008 16.6 0.6 2.4 1 1 0 1 1 1 1 RNA helicase AAA PF00004.29 EAK89010.1 - 0.0022 18.4 1.2 0.0028 18.1 0.3 1.8 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EAK89010.1 - 0.0041 16.4 0.0 0.0077 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin SRPRB PF09439.10 EAK89010.1 - 0.0059 16.1 0.5 0.031 13.7 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EAK89010.1 - 0.0086 15.8 0.1 0.018 14.8 0.1 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EAK89010.1 - 0.011 15.2 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MCM PF00493.23 EAK89010.1 - 0.011 14.8 0.0 0.023 13.8 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain AAA_7 PF12775.7 EAK89010.1 - 0.012 15.1 0.1 0.028 13.9 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 EAK89010.1 - 0.013 15.8 0.1 0.35 11.1 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EAK89010.1 - 0.014 15.1 0.5 0.22 11.2 0.0 2.4 2 1 0 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 EAK89010.1 - 0.018 14.4 0.0 0.029 13.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Sigma54_activ_2 PF14532.6 EAK89010.1 - 0.03 14.4 0.1 0.12 12.5 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 EAK89010.1 - 0.034 14.5 0.1 0.069 13.5 0.1 1.5 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 EAK89010.1 - 0.039 13.3 0.8 1.2 8.5 0.0 2.1 1 1 1 2 2 2 0 Isopentenyl transferase RuvB_N PF05496.12 EAK89010.1 - 0.052 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Thymidylate_kin PF02223.17 EAK89010.1 - 0.063 13.0 3.2 1.2 8.8 0.3 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_14 PF13173.6 EAK89010.1 - 0.078 13.0 2.0 0.094 12.7 0.3 1.8 1 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EAK89010.1 - 0.088 12.1 1.0 0.29 10.4 0.1 2.0 2 1 0 2 2 2 0 KaiC AAA_3 PF07726.11 EAK89010.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ploopntkinase3 PF18751.1 EAK89010.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 ABC_tran PF00005.27 EAK89010.1 - 0.14 12.7 0.5 0.22 12.0 0.5 1.6 1 1 0 1 1 1 0 ABC transporter SIT PF15330.6 EAK89011.1 - 0.014 15.8 0.9 0.016 15.6 0.0 1.7 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Peptidase_M56 PF05569.11 EAK89011.1 - 0.022 14.0 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 NCU-G1 PF15065.6 EAK89011.1 - 0.024 13.7 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 S_4TM PF18159.1 EAK89011.1 - 0.08 12.2 0.3 0.14 11.4 0.3 1.3 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Sigma_reg_N PF13800.6 EAK89011.1 - 0.15 12.3 3.3 0.42 10.9 0.2 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF3377 PF11857.8 EAK89011.1 - 0.24 11.4 2.6 2.3 8.2 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) CBF PF03914.17 EAK89013.1 - 5.4e-14 52.6 0.1 1e-13 51.7 0.0 1.6 2 0 0 2 2 2 1 CBF/Mak21 family ISPD_C PF18706.1 EAK89013.1 - 0.022 14.4 0.2 0.044 13.4 0.2 1.5 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain Pkinase PF00069.25 EAK89014.1 - 2.2e-50 171.5 0.0 1.5e-48 165.5 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK89014.1 - 7.5e-31 107.4 0.0 2.9e-23 82.5 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase RWD PF05773.22 EAK89014.1 - 0.03 14.6 0.4 0.14 12.4 0.4 2.3 1 0 0 1 1 1 0 RWD domain PduV-EutP PF10662.9 EAK89014.1 - 0.034 13.9 0.1 0.083 12.6 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Peptidase_M54 PF07998.11 EAK89015.1 - 1e-16 61.5 3.3 1.3e-16 61.2 3.3 1.1 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_3 PF13582.6 EAK89015.1 - 0.0086 16.6 0.3 0.017 15.6 0.3 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EAK89015.1 - 0.016 15.4 0.4 0.029 14.5 0.4 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 EAK89015.1 - 0.025 14.4 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Matrixin DUF2268 PF10026.9 EAK89015.1 - 0.037 13.6 0.1 0.052 13.1 0.1 1.2 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) ARPC4 PF05856.12 EAK89016.1 - 1.4e-59 200.4 5.8 2.1e-59 199.8 5.8 1.3 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Bromodomain PF00439.25 EAK89017.1 - 1.2e-20 73.4 3.1 1.6e-20 72.9 0.9 2.4 2 0 0 2 2 2 1 Bromodomain Acetyltransf_1 PF00583.25 EAK89017.1 - 1.1e-11 45.0 0.1 2.2e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EAK89017.1 - 6.6e-09 35.8 0.1 1.5e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EAK89017.1 - 8.1e-07 29.4 0.7 1.7e-06 28.3 0.7 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EAK89017.1 - 0.0061 16.5 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EAK89017.1 - 0.036 14.2 0.1 0.076 13.1 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EAK89018.1 - 1e-10 41.4 0.0 3.3e-10 39.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EAK89018.1 - 0.24 11.3 0.0 0.41 10.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ras PF00071.22 EAK89020.1 - 4.1e-59 198.8 0.2 4.9e-59 198.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAK89020.1 - 3.7e-36 124.0 0.1 7e-36 123.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAK89020.1 - 7.7e-17 61.3 0.0 1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EAK89020.1 - 0.00033 20.1 0.0 0.00042 19.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EAK89020.1 - 0.0013 18.8 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAK89020.1 - 0.0032 17.4 0.1 0.39 10.6 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EAK89020.1 - 0.004 16.7 0.1 0.018 14.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EAK89020.1 - 0.06 12.8 0.0 0.63 9.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein YjbT PF17089.5 EAK89020.1 - 0.16 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family DUF3453 PF11935.8 EAK89021.1 - 0.032 13.9 7.2 1.8 8.1 2.8 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3453) AOX PF01786.17 EAK89022.1 - 2.5e-83 278.9 0.0 3.1e-83 278.6 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase Ssl1 PF04056.14 EAK89023.1 - 1.2e-32 113.3 0.1 1.7e-32 112.8 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 EAK89023.1 - 6.6e-08 33.2 0.0 1.3e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_4 PF07975.12 EAK89023.1 - 0.04 14.2 30.7 0.034 14.4 18.2 3.3 2 1 1 3 3 3 0 TFIIH C1-like domain Tfb4 PF03850.14 EAK89023.1 - 6.5 6.2 12.2 3 7.3 9.3 2.1 2 1 0 2 2 2 0 Transcription factor Tfb4 FYVE PF01363.21 EAK89023.1 - 6.9 6.9 25.2 0.49 10.6 12.6 2.6 2 0 0 2 2 2 0 FYVE zinc finger MFS_1 PF07690.16 EAK89024.1 - 2.2e-41 142.0 18.5 1.3e-29 103.2 0.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EAK89024.1 - 2.5e-14 53.0 14.6 5.8e-11 41.9 0.3 3.2 3 0 0 3 3 3 3 Sugar (and other) transporter MFS_1_like PF12832.7 EAK89024.1 - 2e-08 33.5 0.7 2e-08 33.5 0.7 2.6 1 1 1 2 2 2 2 MFS_1 like family Cytochrome-c551 PF10643.9 EAK89024.1 - 0.23 11.0 4.0 0.25 10.9 0.4 2.5 2 1 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Sec34 PF04136.15 EAK89025.1 - 3.6e-10 39.9 9.4 4.2e-10 39.7 7.1 2.4 2 0 0 2 2 2 1 Sec34-like family CRM1_C PF08767.11 EAK89026.1 - 6.5e-75 252.3 19.3 6.5e-75 252.3 19.3 3.6 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EAK89026.1 - 4.4e-29 101.5 7.2 4.4e-29 101.5 7.2 4.3 6 0 0 6 6 6 1 Exportin 1-like protein CRM1_repeat_3 PF18787.1 EAK89026.1 - 9.4e-22 76.9 1.6 6.4e-21 74.2 0.8 2.7 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat_2 PF18784.1 EAK89026.1 - 1.2e-19 69.7 0.8 3.5e-19 68.2 0.3 2.2 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat PF18777.1 EAK89026.1 - 8.3e-10 38.0 0.7 3.5e-09 36.0 0.2 2.3 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EAK89026.1 - 2e-07 30.9 0.5 2e-07 30.9 0.5 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3412 PF11892.8 EAK89026.1 - 0.045 13.8 0.1 0.31 11.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3412) RNA_pol_3_Rpc31 PF11705.8 EAK89026.1 - 1.6 8.9 4.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 LisH_TPL PF17814.1 EAK89027.1 - 3.6e-05 23.3 2.2 5.3e-05 22.8 0.2 2.2 2 0 0 2 2 2 1 LisH-like dimerisation domain WD40 PF00400.32 EAK89027.1 - 5.4e-05 23.9 3.0 4.3 8.4 0.0 4.7 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK89027.1 - 0.0008 19.7 0.4 0.18 12.1 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Chalcone PF02431.15 EAK89028.1 - 0.12 11.8 0.3 0.22 10.9 0.3 1.5 1 0 0 1 1 1 0 Chalcone-flavanone isomerase RabGAP-TBC PF00566.18 EAK89029.1 - 2.1e-23 83.1 10.8 6e-22 78.4 10.7 3.0 1 1 1 2 2 2 1 Rab-GTPase-TBC domain IF-2B PF01008.17 EAK89031.1 - 2.6e-47 161.4 0.5 2.9e-47 161.2 0.5 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family L_lactis_RepB_C PF06430.12 EAK89031.1 - 0.00061 19.8 0.1 0.088 12.8 0.0 2.7 2 0 0 2 2 2 2 Lactococcus lactis RepB C-terminus PP_kinase_C_1 PF17941.1 EAK89031.1 - 0.0048 16.5 0.1 0.01 15.4 0.1 1.5 1 0 0 1 1 1 1 Polyphosphate kinase C-terminal domain 1 RNR_N PF08343.10 EAK89031.1 - 0.018 15.1 0.2 0.046 13.8 0.2 1.7 1 0 0 1 1 1 0 Ribonucleotide reductase N-terminal NADH-u_ox-rdase PF10785.9 EAK89032.1 - 0.11 13.2 0.3 6.4 7.5 0.0 3.7 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit zinc_ribbon_16 PF17034.5 EAK89033.1 - 1.3e-14 54.5 15.7 4.5e-14 52.7 15.7 2.0 1 0 0 1 1 1 1 Zinc-ribbon like family ACAS_N PF16177.5 EAK89033.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.9 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus KH_8 PF17903.1 EAK89036.1 - 3e-32 110.6 2.8 4.4e-32 110.0 0.0 2.6 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 EAK89036.1 - 0.00067 19.4 0.0 0.0022 17.8 0.0 1.9 1 0 0 1 1 1 1 KH domain Tim44 PF04280.15 EAK89037.1 - 2.6e-23 82.7 0.0 1.4e-21 77.1 0.0 2.4 1 1 0 1 1 1 1 Tim44-like domain DDE_Tnp_1_2 PF13586.6 EAK89037.1 - 0.16 12.4 0.0 7.2 7.1 0.0 2.6 2 0 0 2 2 2 0 Transposase DDE domain Peptidase_C54 PF03416.19 EAK89038.1 - 1.5e-53 182.0 3.6 1.9e-53 181.7 3.6 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EAK89038.1 - 0.00033 20.2 0.5 0.00048 19.7 0.5 1.3 1 0 0 1 1 1 1 Peptidase family C78 HpuA PF16960.5 EAK89039.1 - 0.097 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter PROCN PF08083.11 EAK89040.1 - 3.8e-218 724.1 10.2 6.6e-218 723.3 10.2 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EAK89040.1 - 6.5e-124 412.0 1.5 1.4e-123 411.0 1.5 1.6 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EAK89040.1 - 7.9e-88 292.4 3.2 2.1e-87 291.0 3.2 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EAK89040.1 - 7.5e-79 263.0 0.5 2.4e-78 261.4 0.5 1.9 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EAK89040.1 - 1.5e-68 229.0 0.1 3.6e-68 227.8 0.1 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EAK89040.1 - 4.6e-45 151.9 0.6 1.6e-44 150.2 0.6 2.0 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EAK89040.1 - 2.9e-31 107.9 0.2 6.7e-31 106.8 0.2 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain AMP-binding PF00501.28 EAK89041.1 - 1.1e-20 73.7 0.0 1.5e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF3386 PF11866.8 EAK89041.1 - 0.049 13.1 0.1 0.049 13.1 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3386) DUF1542 PF07564.11 EAK89041.1 - 9.3 6.4 9.0 0.76 9.9 1.1 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) BD_b_sandwich PF18820.1 EAK89042.1 - 0.3 11.1 2.4 0.7 9.9 2.4 1.5 1 0 0 1 1 1 0 Bdellovibrio Beta-sandwich Cullin PF00888.22 EAK89044.1 - 5.1e-78 263.2 24.9 1.5e-77 261.7 24.9 1.7 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EAK89044.1 - 1.6e-06 28.0 3.3 3.2e-06 27.1 0.5 3.0 2 0 0 2 2 2 1 Cullin protein neddylation domain zf-C2H2_jaz PF12171.8 EAK89045.1 - 5.4e-08 32.9 1.8 1.1e-07 32.0 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EAK89045.1 - 0.00076 19.8 2.2 0.0019 18.5 1.4 1.9 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EAK89045.1 - 0.0019 18.5 0.3 0.0036 17.6 0.3 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF1677 PF07911.13 EAK89045.1 - 0.01 16.2 0.7 0.38 11.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1677) ADK PF00406.22 EAK89046.1 - 0.041 14.0 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase Paf1 PF03985.13 EAK89046.1 - 0.098 11.6 1.7 0.61 9.0 0.1 2.4 2 1 1 3 3 3 0 Paf1 POP1 PF06978.11 EAK89047.1 - 4.4e-36 124.8 11.8 4.4e-36 124.8 11.8 2.8 3 1 0 3 3 3 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EAK89047.1 - 2.5e-12 47.0 0.0 6.9e-12 45.6 0.0 1.9 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.11 EAK89047.1 - 0.00066 19.6 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pox_A22 PF04848.13 EAK89047.1 - 0.057 13.5 0.4 0.18 11.9 0.4 1.8 1 0 0 1 1 1 0 Poxvirus A22 protein Rubredoxin_2 PF18073.1 EAK89047.1 - 0.23 11.2 0.9 0.49 10.2 0.9 1.5 1 0 0 1 1 1 0 Rubredoxin metal binding domain SPT16 PF08644.11 EAK89047.1 - 0.5 10.5 6.0 0.71 10.0 0.5 2.5 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) HSCB_C PF07743.13 EAK89048.1 - 5.4e-10 39.6 0.9 9.5e-10 38.8 0.9 1.4 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EAK89048.1 - 0.0054 16.8 0.2 0.018 15.1 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain TH1 PF04858.13 EAK89049.1 - 8.2e-13 47.9 3.1 3.1e-06 26.1 0.0 4.9 5 0 0 5 5 5 4 TH1 protein Ank_2 PF12796.7 EAK89050.1 - 0.0099 16.5 0.0 0.021 15.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Herpes_UL52 PF03121.15 EAK89051.1 - 2.8e-14 52.8 2.8 5e-14 52.0 0.4 2.4 2 0 0 2 2 2 1 Herpesviridae UL52/UL70 DNA primase DUF3528 PF12045.8 EAK89051.1 - 0.099 13.3 0.1 16 6.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3528) TF_Zn_Ribbon PF08271.12 EAK89052.1 - 0.00012 21.5 2.2 0.00032 20.1 2.2 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding A2L_zn_ribbon PF08792.10 EAK89052.1 - 0.0002 21.0 3.3 0.0005 19.7 3.3 1.7 1 0 0 1 1 1 1 A2L zinc ribbon domain zf-RRN7 PF11781.8 EAK89052.1 - 0.3 10.8 3.9 0.57 9.9 3.9 1.5 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TLD PF07534.16 EAK89053.1 - 2.4e-26 92.6 0.1 6.4e-26 91.2 0.1 1.8 1 0 0 1 1 1 1 TLD PhoLip_ATPase_C PF16212.5 EAK89054.1 - 1.7e-54 185.2 25.5 1.7e-54 185.2 25.5 2.9 2 1 1 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EAK89054.1 - 4.8e-18 64.6 1.9 4.8e-18 64.6 1.9 3.0 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EAK89054.1 - 2e-15 57.6 0.4 2.5e-06 27.9 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EAK89054.1 - 3.8e-05 23.6 3.7 0.00024 20.9 0.2 3.2 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EAK89054.1 - 6.6e-05 22.9 0.1 0.00055 20.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EAK89054.1 - 0.00026 20.6 4.9 0.00042 19.9 0.0 3.0 2 1 0 2 2 2 1 E1-E2 ATPase DUF4392 PF14336.6 EAK89054.1 - 0.036 13.5 0.1 0.29 10.6 0.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4392) DUF2183 PF09949.9 EAK89054.1 - 0.16 12.3 1.2 1.4 9.3 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2183) TMEM40 PF15817.5 EAK89054.1 - 8.4 6.2 7.5 17 5.2 3.5 3.0 2 0 0 2 2 2 0 Transmembrane protein 40 family CENP-C_C PF11699.8 EAK89055.1 - 0.00035 20.7 0.0 0.0009 19.4 0.0 1.6 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 EAK89055.1 - 0.21 11.3 0.0 0.65 9.8 0.0 1.8 1 0 0 1 1 1 0 Cupin domain DnaJ PF00226.31 EAK89056.1 - 3e-23 81.7 0.1 5.7e-23 80.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 EAK89056.1 - 6.8e-05 22.8 0.0 0.00019 21.4 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin Wx5_PLAF3D7 PF09688.10 EAK89056.1 - 0.041 13.9 0.1 0.13 12.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) DAGK_acc PF00609.19 EAK89058.1 - 1.4e-37 129.5 0.2 3e-14 53.6 0.0 3.5 3 0 0 3 3 3 3 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EAK89058.1 - 9.9e-27 93.1 0.0 1.8e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EAK89058.1 - 1.4e-09 37.7 25.5 3.2e-05 23.7 7.8 3.0 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EAK89058.1 - 1.9 8.7 13.9 3.7 7.7 3.2 2.7 2 0 0 2 2 2 0 KIAA1045 RING finger DUF498 PF04430.14 EAK89059.1 - 0.045 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) AlbA_2 PF04326.14 EAK89059.1 - 0.079 13.3 4.7 0.044 14.1 1.0 2.2 2 0 0 2 2 2 0 Putative DNA-binding domain Pullulanase_Ins PF18494.1 EAK89060.1 - 0.068 13.6 0.3 0.28 11.7 0.3 2.1 1 0 0 1 1 1 0 Pullulanase Ins domain RRM_1 PF00076.22 EAK89063.1 - 8.4e-18 64.0 0.2 1.8e-10 40.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAK89063.1 - 1e-05 25.1 0.0 0.0022 17.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAK89063.1 - 1.6e-05 24.7 0.0 0.00043 20.1 0.0 2.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif Methyltransf_16 PF10294.9 EAK89064.1 - 1.1e-10 41.6 0.1 4e-10 39.7 0.1 1.9 1 1 0 1 1 1 1 Lysine methyltransferase DUF2866 PF11065.8 EAK89064.1 - 0.00048 20.1 0.0 0.00098 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2866) FAM86 PF14904.6 EAK89064.1 - 0.00065 19.7 0.1 0.0016 18.5 0.1 1.7 1 0 0 1 1 1 1 Family of unknown function PrmA PF06325.13 EAK89064.1 - 0.026 13.9 0.0 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RabGAP-TBC PF00566.18 EAK89065.1 - 5.7e-51 173.2 8.6 1.2e-50 172.1 8.6 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain AbiJ_NTD4 PF18863.1 EAK89065.1 - 0.011 16.2 0.9 0.04 14.4 0.1 2.1 2 1 0 2 2 2 0 AbiJ N-terminal domain 4 Histone PF00125.24 EAK89066.1 - 1.4e-51 174.3 1.3 1.5e-51 174.1 1.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EAK89066.1 - 0.00032 21.0 0.0 0.00047 20.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EAK89066.1 - 0.00033 20.7 0.1 0.00054 20.1 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EAK89066.1 - 0.00087 19.9 2.9 0.0011 19.6 2.9 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EAK89066.1 - 0.012 15.9 0.1 0.021 15.1 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EAK89066.1 - 0.034 14.2 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Proteasome PF00227.26 EAK89067.1 - 6.7e-50 169.2 0.2 8.3e-50 168.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit AIRS PF00586.24 EAK89067.1 - 0.076 13.7 0.1 0.15 12.7 0.1 1.6 1 0 0 1 1 1 0 AIR synthase related protein, N-terminal domain TPR_2 PF07719.17 EAK89068.1 - 9.2e-10 37.9 0.6 0.033 14.3 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EAK89068.1 - 6e-08 32.2 4.9 0.082 12.8 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EAK89068.1 - 5.4e-05 23.3 0.4 0.0034 17.6 0.0 4.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EAK89068.1 - 0.0003 21.4 0.0 0.031 14.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EAK89068.1 - 0.00085 19.8 0.0 0.15 12.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK89068.1 - 0.0029 17.8 4.5 0.39 11.0 0.1 4.3 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EAK89068.1 - 0.023 14.9 11.4 46 4.6 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.6 EAK89068.1 - 0.034 14.4 0.1 44 4.4 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EAK89068.1 - 0.039 13.7 2.2 2.6 7.8 0.1 2.9 3 0 0 3 3 3 0 TPR repeat DUF1965 PF09248.10 EAK89068.1 - 0.071 12.9 1.3 0.2 11.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1965) Fis1_TPR_C PF14853.6 EAK89068.1 - 0.2 11.8 2.4 0.72 10.0 0.0 3.1 3 1 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Thioredoxin PF00085.20 EAK89070.1 - 9.6e-09 35.2 0.0 2.7e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin DUF4284 PF14112.6 EAK89070.1 - 0.01 16.8 12.9 0.049 14.5 0.9 2.9 3 0 0 3 3 3 0 Immunity protein 22 DASH_Duo1 PF08651.10 EAK89071.1 - 3.4 7.5 8.3 0.4 10.5 0.2 3.2 4 0 0 4 4 4 0 DASH complex subunit Duo1 Peptidase_M24 PF00557.24 EAK89072.1 - 1.5e-15 57.5 0.0 2.1e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 eIF3_subunit PF08597.10 EAK89073.1 - 1.4e-09 38.3 3.0 1.4e-09 38.3 3.0 1.6 1 1 1 2 2 2 1 Translation initiation factor eIF3 subunit GYF PF02213.16 EAK89074.1 - 1.6e-08 34.0 0.3 6.6e-08 32.1 0.1 2.1 3 0 0 3 3 3 1 GYF domain IQ PF00612.27 EAK89074.1 - 0.038 13.8 1.1 0.088 12.6 1.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ribosomal_S13 PF00416.22 EAK89075.1 - 6.1e-53 178.6 3.8 7.1e-53 178.4 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Ufd2P_core PF10408.9 EAK89077.1 - 2e-126 423.1 23.7 2.7e-126 422.7 23.7 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EAK89077.1 - 1.1e-23 83.1 1.9 6.7e-23 80.7 1.4 2.4 2 0 0 2 2 2 1 U-box domain DUF2999 PF11212.8 EAK89077.1 - 0.035 14.4 0.1 0.11 12.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) Spore_YhaL PF14147.6 EAK89078.1 - 1.4 8.7 4.3 2.3 8.0 4.3 1.4 1 0 0 1 1 1 0 Sporulation protein YhaL Nucleoporin2 PF04096.14 EAK89079.1 - 3.7e-38 131.0 0.0 8.8e-38 129.8 0.0 1.7 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 EAK89079.1 - 4.1e-13 49.1 0.0 7.9e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 Nuclear protein 96 Prenyltrans PF00432.21 EAK89080.1 - 4e-19 68.1 0.0 1.2e-08 34.6 0.0 4.1 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat AAA_5 PF07728.14 EAK89082.1 - 0.058 13.4 0.0 0.43 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK89082.1 - 0.083 13.3 0.0 0.62 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EAK89082.1 - 0.1 12.9 0.0 2.1 8.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EAK89082.1 - 0.18 11.5 0.0 2.8 7.6 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain PARG_cat PF05028.14 EAK89083.1 - 0.0057 16.0 0.2 0.0077 15.6 0.2 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF4128 PF13554.6 EAK89083.1 - 0.1 12.6 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function AAA PF00004.29 EAK89084.1 - 5e-06 27.0 0.1 6.4e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EAK89084.1 - 0.013 15.4 0.3 0.018 15.0 0.3 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EAK89084.1 - 0.028 14.4 0.7 0.063 13.3 0.7 1.6 1 1 0 1 1 1 0 AAA domain DUF2608 PF11019.8 EAK89084.1 - 0.053 13.0 0.1 0.073 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) AAA_16 PF13191.6 EAK89084.1 - 0.12 12.7 0.0 3 8.2 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain UTP15_C PF09384.10 EAK89085.1 - 2.3e-13 50.1 2.6 4.1e-13 49.3 2.6 1.4 1 0 0 1 1 1 1 UTP15 C terminal ANAPC4_WD40 PF12894.7 EAK89085.1 - 4e-10 39.9 0.3 0.042 14.2 0.0 4.4 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EAK89085.1 - 1.6e-07 31.9 4.9 0.57 11.1 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Utp13 PF08625.11 EAK89085.1 - 0.03 14.2 0.4 0.2 11.6 0.5 2.3 2 1 0 2 2 2 0 Utp13 specific WD40 associated domain Nkap_C PF06047.11 EAK89086.1 - 6.9e-43 144.9 4.3 6.9e-43 144.9 4.3 1.9 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain Proteasome PF00227.26 EAK89087.1 - 2.9e-48 163.9 0.2 3.7e-48 163.5 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EAK89087.1 - 7.3e-14 51.1 0.1 1.2e-13 50.5 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PTPLA PF04387.14 EAK89088.1 - 2.2e-49 167.4 8.2 3.2e-49 166.8 8.2 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA ketoacyl-synt PF00109.26 EAK89089.1 - 5e-227 750.3 2.1 6.1e-82 275.0 0.4 4.0 4 0 0 4 4 3 3 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EAK89089.1 - 1.8e-172 568.8 0.0 1.1e-60 204.6 0.0 4.5 4 0 0 4 4 4 3 KR domain Ketoacyl-synt_C PF02801.22 EAK89089.1 - 8.5e-123 403.2 0.3 7.4e-42 142.1 0.0 3.6 3 0 0 3 3 3 3 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 EAK89089.1 - 6.9e-116 387.2 0.0 7.6e-47 160.4 0.0 3.3 3 0 0 3 3 3 3 Acyl transferase domain AMP-binding PF00501.28 EAK89089.1 - 1.8e-66 224.5 0.0 1.4e-38 132.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PS-DH PF14765.6 EAK89089.1 - 2.4e-66 224.0 0.0 7.5e-27 94.3 0.0 4.1 3 2 0 3 3 3 3 Polyketide synthase dehydratase NAD_binding_4 PF07993.12 EAK89089.1 - 1.3e-65 221.2 0.0 1.7e-58 197.8 0.0 4.6 4 0 0 4 4 4 2 Male sterility protein ADH_zinc_N PF00107.26 EAK89089.1 - 3.9e-65 217.7 0.1 1.5e-19 70.3 0.0 4.6 4 0 0 4 4 4 3 Zinc-binding dehydrogenase PP-binding PF00550.25 EAK89089.1 - 6.4e-60 199.4 7.0 3.5e-16 59.3 0.2 4.7 4 0 0 4 4 4 4 Phosphopantetheine attachment site adh_short PF00106.25 EAK89089.1 - 2e-34 118.8 7.7 5.4e-11 42.3 0.0 6.7 6 0 0 6 6 6 3 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EAK89089.1 - 1.5e-29 103.7 0.0 6.9e-08 33.6 0.0 3.9 3 0 0 3 3 3 3 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EAK89089.1 - 2.7e-29 102.4 0.0 4e-10 39.6 0.0 4.1 3 0 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EAK89089.1 - 8.9e-29 100.6 0.0 1.1e-07 31.6 0.0 4.7 4 0 0 4 4 4 4 NAD dependent epimerase/dehydratase family KAsynt_C_assoc PF16197.5 EAK89089.1 - 3.9e-26 91.7 0.5 1.2e-07 32.1 0.0 3.8 3 0 0 3 3 3 3 Ketoacyl-synthetase C-terminal extension ADH_N PF08240.12 EAK89089.1 - 4.5e-18 65.1 4.2 0.00016 21.5 0.1 4.2 3 0 0 3 3 3 3 Alcohol dehydrogenase GroES-like domain GDP_Man_Dehyd PF16363.5 EAK89089.1 - 8e-18 64.9 0.4 2.5e-06 27.1 0.0 4.8 4 0 0 4 4 4 4 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EAK89089.1 - 5.3e-15 55.3 4.0 0.00048 19.3 0.0 4.4 4 0 0 4 4 4 3 Polysaccharide biosynthesis protein Thiolase_N PF00108.23 EAK89089.1 - 3.6e-12 46.2 11.4 0.00049 19.5 2.3 3.7 3 0 0 3 3 3 3 Thiolase, N-terminal domain 3Beta_HSD PF01073.19 EAK89089.1 - 8.6e-12 44.6 3.2 0.0029 16.6 0.1 4.8 4 1 0 4 4 4 2 3-beta hydroxysteroid dehydrogenase/isomerase family 2-Hacid_dh_C PF02826.19 EAK89089.1 - 0.00095 18.6 2.4 33 3.8 0.0 6.0 5 3 0 5 5 5 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EAK89089.1 - 0.0078 16.3 0.1 32 4.6 0.0 4.2 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase DUF2865 PF11064.8 EAK89089.1 - 0.049 14.0 1.3 98 3.4 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2865) HTH_24 PF13412.6 EAK89089.1 - 0.92 9.1 4.1 67 3.2 0.1 4.0 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding ACP_syn_III PF08545.10 EAK89089.1 - 1.3 8.9 6.3 7.9 6.4 0.4 3.7 3 1 0 3 3 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1860 PF08949.10 EAK89089.1 - 2.7 7.7 8.4 68 3.1 0.2 4.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1860) Asp_protease PF09668.10 EAK89090.1 - 3.4e-57 191.6 1.1 4.5e-57 191.2 0.2 1.6 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EAK89090.1 - 5.8e-19 68.4 0.0 1.1e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EAK89090.1 - 4.9e-09 36.7 0.0 9.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 EAK89090.1 - 5e-08 32.7 0.0 9.8e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RVP_2 PF08284.11 EAK89090.1 - 1.3e-05 25.0 0.1 2.9e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A3 PF02160.15 EAK89090.1 - 2e-05 24.2 0.5 5.2e-05 22.8 0.5 1.7 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) RVP PF00077.20 EAK89090.1 - 0.00029 21.1 0.0 0.00061 20.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease ubiquitin PF00240.23 EAK89090.1 - 0.021 14.6 0.2 0.05 13.4 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin family UBA_4 PF14555.6 EAK89090.1 - 0.07 13.0 0.2 0.19 11.6 0.2 1.7 1 0 0 1 1 1 0 UBA-like domain IFP_35_N PF07334.13 EAK89091.1 - 0.34 11.0 4.6 2.3 8.3 0.1 2.7 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4094 PF13334.6 EAK89091.1 - 9.5 6.7 6.6 1.4 9.3 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) PolyA_pol PF01743.20 EAK89092.1 - 1.3e-21 77.3 0.1 4.5e-21 75.6 0.1 2.0 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EAK89092.1 - 0.013 15.2 0.0 0.045 13.5 0.0 2.0 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A CD20 PF04103.15 EAK89092.1 - 0.22 11.6 0.3 0.43 10.7 0.3 1.5 1 0 0 1 1 1 0 CD20-like family BLOC1_2 PF10046.9 EAK89093.1 - 0.35 11.2 5.2 0.31 11.4 1.0 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Myosin_head PF00063.21 EAK89094.1 - 6.7e-35 120.4 11.2 1.7e-33 115.8 2.8 3.9 3 1 0 3 3 3 1 Myosin head (motor domain) RCC1 PF00415.18 EAK89094.1 - 1e-27 96.5 5.7 6.3e-09 36.3 0.0 6.8 6 2 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EAK89094.1 - 1.7e-13 49.0 33.3 4.7e-05 22.8 0.5 7.6 7 0 0 7 7 7 3 IQ calmodulin-binding motif RCC1_2 PF13540.6 EAK89094.1 - 5e-10 38.9 26.9 1.2e-06 28.1 0.4 7.0 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat CSRNP_N PF16019.5 EAK89094.1 - 0.35 10.7 1.9 0.85 9.5 0.2 2.4 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus BK_channel_a PF03493.18 EAK89096.1 - 2.7e-14 53.1 0.1 4.6e-07 30.0 0.0 3.4 3 0 0 3 3 3 2 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 EAK89096.1 - 6.3e-12 45.3 9.6 6.3e-12 45.3 9.6 2.6 2 0 0 2 2 2 1 Ion channel 2OG-FeII_Oxy_3 PF13640.6 EAK89097.1 - 5e-12 46.6 0.0 1.2e-11 45.3 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EAK89097.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase WD40 PF00400.32 EAK89098.1 - 3.6e-09 37.1 0.3 0.00065 20.5 0.1 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat HUN PF08729.10 EAK89099.1 - 3.9e-06 26.8 4.9 3.9e-06 26.8 4.9 2.6 2 0 0 2 2 2 1 HPC2 and ubinuclein domain AP2 PF00847.20 EAK89100.1 - 0.48 10.7 2.2 0.54 10.5 0.1 2.1 2 0 0 2 2 2 0 AP2 domain Filament PF00038.21 EAK89101.1 - 0.0032 17.1 4.0 0.0035 17.0 4.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.11 EAK89101.1 - 0.004 17.4 4.8 0.0061 16.8 4.8 1.3 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Npa1 PF11707.8 EAK89101.1 - 0.0045 16.4 1.7 0.0049 16.3 1.7 1.0 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Gly_acyl_tr_C PF08444.10 EAK89101.1 - 0.0063 16.7 0.1 0.0098 16.1 0.1 1.3 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region DUF5102 PF17104.5 EAK89101.1 - 0.01 15.9 1.5 0.011 15.8 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) Atg14 PF10186.9 EAK89101.1 - 0.015 14.4 6.3 0.016 14.3 6.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATPase_2 PF01637.18 EAK89101.1 - 0.025 14.5 1.3 0.026 14.4 1.3 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DXP_synthase_N PF13292.6 EAK89101.1 - 0.034 13.4 1.5 0.71 9.0 0.1 2.1 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase CAAP1 PF15335.6 EAK89101.1 - 0.046 14.3 7.0 0.14 12.7 4.1 2.9 2 1 0 2 2 2 0 Caspase activity and apoptosis inhibitor 1 Death_2 PF14786.6 EAK89101.1 - 0.05 13.5 0.1 0.055 13.4 0.1 1.2 1 0 0 1 1 1 0 Tube Death domain DUF948 PF06103.11 EAK89101.1 - 0.067 13.4 0.8 0.13 12.5 0.3 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Nbl1_Borealin_N PF10444.9 EAK89101.1 - 0.083 12.5 4.1 2.9 7.6 3.3 3.3 1 1 1 2 2 2 0 Nbl1 / Borealin N terminal SAP PF02037.27 EAK89101.1 - 0.084 12.6 1.1 0.22 11.3 1.1 1.8 1 0 0 1 1 1 0 SAP domain Vps51 PF08700.11 EAK89101.1 - 0.1 12.7 6.8 4.7 7.4 6.6 2.4 1 1 0 1 1 1 0 Vps51/Vps67 GAT PF03127.14 EAK89101.1 - 0.2 12.0 10.7 0.69 10.3 0.5 2.5 2 1 1 3 3 3 0 GAT domain Exonuc_VII_L PF02601.15 EAK89101.1 - 0.22 11.1 3.2 0.23 11.0 3.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 EAK89101.1 - 0.33 11.0 3.9 0.43 10.6 3.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 EAK89101.1 - 0.36 10.0 5.6 0.4 9.9 5.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein Serine_rich PF08824.10 EAK89101.1 - 0.36 10.8 6.7 0.35 10.9 4.4 2.0 2 1 0 2 2 2 0 Serine rich protein interaction domain LSM PF01423.22 EAK89101.1 - 0.41 10.4 2.7 4 7.2 0.1 2.8 3 0 0 3 3 3 0 LSM domain Aida_N PF08910.10 EAK89101.1 - 1.6 9.1 5.3 1.6 9.2 4.1 1.6 1 1 1 2 2 2 0 Aida N-terminus AAA_23 PF13476.6 EAK89101.1 - 1.9 9.0 11.6 2.4 8.6 11.6 1.1 1 0 0 1 1 1 0 AAA domain SAP30_Sin3_bdg PF13867.6 EAK89102.1 - 0.0014 18.9 0.7 0.0037 17.6 0.7 1.8 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Myosin_N PF02736.19 EAK89102.1 - 0.084 12.7 0.3 0.084 12.7 0.3 1.9 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain TCTP PF00838.17 EAK89103.1 - 1.5e-52 178.3 4.1 1.6e-52 178.2 4.1 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF2070 PF09843.9 EAK89103.1 - 0.004 15.5 0.5 0.013 13.8 0.2 1.7 1 1 1 2 2 2 1 Predicted membrane protein (DUF2070) Tma16 PF11176.8 EAK89103.1 - 0.045 13.6 0.4 0.066 13.1 0.2 1.5 2 0 0 2 2 2 0 Translation machinery-associated protein 16 RadC PF04002.15 EAK89103.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 RadC-like JAB domain TMEM154 PF15102.6 EAK89104.1 - 0.13 12.1 2.7 0.27 11.1 0.7 2.2 2 0 0 2 2 2 0 TMEM154 protein family PRP38 PF03371.15 EAK89105.1 - 3.6e-44 150.7 0.4 4.5e-44 150.4 0.4 1.1 1 0 0 1 1 1 1 PRP38 family SART-1 PF03343.13 EAK89105.1 - 0.034 12.7 0.0 0.047 12.3 0.0 1.2 1 0 0 1 1 1 0 SART-1 family Collar PF07484.12 EAK89105.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Phage Tail Collar Domain Acetyltransf_1 PF00583.25 EAK89107.1 - 3.2e-08 33.8 0.0 5.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EAK89107.1 - 0.00064 19.7 0.0 0.0013 18.6 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EAK89107.1 - 0.00065 20.1 0.0 0.0021 18.4 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EAK89107.1 - 0.023 14.8 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DSPc PF00782.20 EAK89108.1 - 3.2e-07 30.2 0.0 6.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EAK89108.1 - 0.0088 16.0 0.0 0.021 14.8 0.0 1.5 2 0 0 2 2 2 1 Tyrosine phosphatase family CDKN3 PF05706.12 EAK89108.1 - 0.012 15.3 0.1 0.021 14.5 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 EAK89108.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase RNA_POL_M_15KD PF02150.16 EAK89109.1 - 1.4e-07 31.3 8.3 1.4e-07 31.3 8.3 3.7 3 1 1 4 4 4 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EAK89109.1 - 6.7e-07 29.1 0.5 6.7e-07 29.1 0.5 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.7 EAK89109.1 - 0.0025 17.8 8.1 0.038 14.0 1.6 2.7 2 1 0 2 2 2 2 Double zinc ribbon DUF3795 PF12675.7 EAK89109.1 - 0.023 15.1 5.6 0.41 11.1 0.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3795) A2L_zn_ribbon PF08792.10 EAK89109.1 - 0.19 11.5 0.1 0.19 11.5 0.1 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain CDH-cyt PF16010.5 EAK89109.1 - 0.32 10.7 1.6 0.84 9.3 0.1 2.0 2 0 0 2 2 2 0 Cytochrome domain of cellobiose dehydrogenase zinc_ribbon_15 PF17032.5 EAK89109.1 - 0.96 10.2 8.5 14 6.5 0.6 3.4 2 1 1 3 3 3 0 zinc-ribbon family zinc_ribbon_10 PF10058.9 EAK89109.1 - 1.9 8.3 11.9 3.6 7.4 0.2 3.7 3 1 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein RNHCP PF12647.7 EAK89109.1 - 3.5 7.7 7.7 7.2 6.7 1.0 3.1 2 2 1 3 3 3 0 RNHCP domain zf-AN1 PF01428.16 EAK89109.1 - 4.6 7.5 11.0 16 5.7 0.1 4.1 3 1 1 4 4 4 0 AN1-like Zinc finger EGF_CA PF07645.15 EAK89110.1 - 2.9e-56 187.4 133.1 4e-10 39.7 8.6 10.0 10 0 0 10 10 10 8 Calcium-binding EGF domain cEGF PF12662.7 EAK89110.1 - 1.4e-50 168.8 56.4 4e-09 36.2 0.6 9.0 8 0 0 8 8 8 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EAK89110.1 - 6.9e-29 99.8 128.8 1.4e-07 31.7 8.9 9.4 9 0 0 9 9 9 7 Coagulation Factor Xa inhibitory site EGF PF00008.27 EAK89110.1 - 1.7e-19 69.8 116.8 5.2e-05 23.5 5.7 10.2 9 1 0 9 9 9 8 EGF-like domain EGF_3 PF12947.7 EAK89110.1 - 7.6e-08 32.4 107.2 0.0029 17.8 5.3 10.2 9 2 0 9 9 9 6 EGF domain hEGF PF12661.7 EAK89110.1 - 0.00013 22.5 99.3 0.028 15.0 2.8 11.2 10 2 0 10 10 10 6 Human growth factor-like EGF Tme5_EGF_like PF09064.10 EAK89110.1 - 0.018 14.9 4.9 0.018 14.9 4.9 8.4 8 0 0 8 8 8 0 Thrombomodulin like fifth domain, EGF-like CK_II_beta PF01214.18 EAK89111.1 - 5.5e-61 205.6 0.0 8.8e-61 204.9 0.0 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Tmemb_9 PF05434.11 EAK89111.1 - 1.6 8.6 4.9 0.37 10.7 0.2 1.9 2 0 0 2 2 2 0 TMEM9 HupE_UreJ PF04955.12 EAK89114.1 - 0.2 11.1 2.0 0.49 9.8 1.0 1.9 2 0 0 2 2 2 0 HupE / UreJ protein PI3K_1B_p101 PF10486.9 EAK89115.1 - 0.11 10.2 8.9 0.12 10.1 7.7 1.6 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Trypan_PARP PF05887.11 EAK89115.1 - 4.1 7.4 17.0 0.05 13.6 9.4 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF3959 PF13105.6 EAK89115.1 - 5.3 6.5 8.9 11 5.4 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Cse1 PF08506.10 EAK89116.1 - 9.3e-39 133.3 2.9 7.2e-37 127.1 2.9 2.4 1 1 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 EAK89116.1 - 1e-38 133.0 2.6 1e-38 133.0 2.6 1.7 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 EAK89116.1 - 3.7e-11 42.8 0.0 2e-10 40.4 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain DprA_WH PF17782.1 EAK89117.1 - 0.088 12.9 0.1 0.29 11.3 0.1 1.9 1 0 0 1 1 1 0 DprA winged helix domain PG_binding_1 PF01471.18 EAK89118.1 - 0.046 13.9 0.1 0.14 12.4 0.0 1.8 1 1 1 2 2 2 0 Putative peptidoglycan binding domain CCDC74_C PF14917.6 EAK89118.1 - 0.099 13.2 0.7 0.5 10.9 0.1 2.2 2 0 0 2 2 2 0 Coiled coil protein 74, C terminal TT_ORF2 PF02957.15 EAK89119.1 - 0.027 15.4 1.7 0.044 14.7 1.7 1.3 1 0 0 1 1 1 0 TT viral ORF2 RXT2_N PF08595.11 EAK89119.1 - 0.059 13.4 7.3 0.11 12.5 7.3 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Use1 PF09753.9 EAK89119.1 - 0.071 12.8 3.4 0.12 12.1 3.4 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 CENP-B_dimeris PF09026.10 EAK89119.1 - 0.21 12.0 12.8 0.44 11.0 12.8 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EAK89119.1 - 0.49 10.1 13.6 0.82 9.4 13.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein WRNPLPNID PF15017.6 EAK89119.1 - 0.84 10.6 11.1 1.9 9.4 11.1 1.6 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box ANAPC15 PF15243.6 EAK89119.1 - 2.5 8.6 12.5 5.8 7.4 12.5 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 NOA36 PF06524.12 EAK89119.1 - 3.4 6.9 14.3 5.9 6.1 14.3 1.3 1 0 0 1 1 1 0 NOA36 protein SesA PF17107.5 EAK89120.1 - 0.021 15.0 8.0 0.031 14.5 1.5 2.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PTPS PF01242.19 EAK89120.1 - 0.1 12.6 2.0 4.5 7.3 0.1 2.4 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase DUF3800 PF12686.7 EAK89120.1 - 1 10.0 4.3 6.5 7.4 4.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) LAGLIDADG_3 PF14528.6 EAK89120.1 - 1.3 9.3 10.7 0.46 10.8 0.4 3.1 1 1 2 3 3 3 0 LAGLIDADG-like domain PMC2NT PF08066.12 EAK89120.1 - 2.1 9.1 6.2 1.4 9.6 0.3 2.9 2 1 1 3 3 3 0 PMC2NT (NUC016) domain RNase_J_C PF17770.1 EAK89120.1 - 2.2 9.4 6.5 3.1 8.9 0.1 3.5 2 2 2 4 4 4 0 Ribonuclease J C-terminal domain MnmE_helical PF12631.7 EAK89120.1 - 2.7 8.1 8.5 4.9 7.3 8.3 1.5 1 1 0 1 1 1 0 MnmE helical domain DUF745 PF05335.13 EAK89120.1 - 5.6 6.6 7.2 6.6 6.4 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) PCRF PF03462.18 EAK89120.1 - 5.6 6.8 9.4 3 7.7 2.1 2.2 2 0 0 2 2 2 0 PCRF domain BLOC1_2 PF10046.9 EAK89125.1 - 0.00064 20.0 1.3 0.043 14.1 0.2 2.3 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Dad4 PF08650.10 EAK89125.1 - 0.049 13.6 0.1 0.3 11.1 0.2 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad4 XhlA PF10779.9 EAK89125.1 - 0.06 13.6 0.2 0.43 10.8 0.1 2.1 2 0 0 2 2 2 0 Haemolysin XhlA FlxA PF14282.6 EAK89125.1 - 0.083 12.9 0.3 0.28 11.2 0.3 1.9 1 0 0 1 1 1 0 FlxA-like protein Prefoldin PF02996.17 EAK89125.1 - 0.093 12.6 0.5 0.093 12.6 0.5 2.0 3 0 0 3 3 3 0 Prefoldin subunit DASH_Dad3 PF08656.10 EAK89125.1 - 0.33 11.1 5.9 7.5 6.7 0.1 2.7 2 1 0 2 2 2 0 DASH complex subunit Dad3 FapA PF03961.13 EAK89125.1 - 0.38 9.3 4.7 0.42 9.2 4.0 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A YvrJ PF12841.7 EAK89125.1 - 4.3 6.9 5.6 5.1 6.7 1.8 2.4 2 0 0 2 2 2 0 YvrJ protein family Med9 PF07544.13 EAK89126.1 - 0.23 11.6 2.4 0.77 9.9 0.7 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Fungus-induced PF10917.8 EAK89126.1 - 3.3 8.1 4.9 0.92 9.9 0.5 2.4 3 0 0 3 3 3 0 Fungus-induced protein Peroxin-13_N PF04088.13 EAK89129.1 - 0.0011 19.3 0.4 0.6 10.4 0.1 2.3 2 0 0 2 2 2 2 Peroxin 13, N-terminal region FH2 PF02181.23 EAK89129.1 - 0.029 13.5 4.4 0.035 13.2 1.4 2.6 1 1 0 1 1 1 0 Formin Homology 2 Domain Peptidase_C34 PF05413.11 EAK89129.1 - 0.13 12.5 0.2 0.47 10.7 0.1 2.0 2 1 0 2 2 2 0 Putative closterovirus papain-like endopeptidase RNase_P_p30 PF01876.16 EAK89130.1 - 2.6e-52 177.4 0.1 1.4e-47 161.9 0.1 2.1 2 0 0 2 2 2 2 RNase P subunit p30 START PF01852.19 EAK89131.1 - 8.7e-08 31.8 0.1 4.9e-07 29.4 0.1 1.9 1 1 0 1 1 1 1 START domain HV_small_capsid PF17086.5 EAK89131.1 - 0.038 14.3 0.0 0.46 10.8 0.0 2.4 2 0 0 2 2 2 0 Small capsid protein of Herpesviridae Neurensin PF14927.6 EAK89132.1 - 0.0011 18.7 2.0 0.5 10.1 0.4 2.8 3 0 0 3 3 3 2 Neurensin DUF2730 PF10805.8 EAK89132.1 - 0.011 15.8 0.8 2.1 8.5 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF308 PF03729.13 EAK89132.1 - 0.093 13.1 11.0 0.052 13.9 5.6 2.4 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) Phage_holin_2_1 PF04971.12 EAK89132.1 - 0.095 12.7 0.7 0.33 11.0 0.7 1.9 1 0 0 1 1 1 0 Bacteriophage P21 holin S DUF4064 PF13273.6 EAK89132.1 - 2.1 8.7 10.1 1.6 9.1 0.0 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF4064) TRIQK PF15168.6 EAK89132.1 - 3 7.8 9.0 5.7 6.9 0.7 3.3 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family Glyco_hydro_31 PF01055.26 EAK89133.1 - 3.6e-87 293.4 0.1 1.8e-86 291.1 0.1 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EAK89133.1 - 2e-15 56.9 0.3 1.1e-14 54.5 0.3 2.4 1 0 0 1 1 1 1 Galactose mutarotase-like CHDNT PF08073.12 EAK89133.1 - 0.0078 16.2 0.3 0.2 11.7 0.1 2.6 2 0 0 2 2 2 1 CHDNT (NUC034) domain DUF5110 PF17137.4 EAK89133.1 - 0.048 13.9 0.2 0.16 12.3 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) DIX PF00778.17 EAK89134.1 - 8.6e-12 44.7 0.1 1.3e-11 44.2 0.1 1.2 1 0 0 1 1 1 1 DIX domain Mito_fiss_reg PF05308.11 EAK89134.1 - 0.0029 17.7 9.4 0.0039 17.3 9.4 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator PRIMA1 PF16101.5 EAK89134.1 - 0.017 15.1 14.7 0.03 14.3 14.7 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mucin PF01456.17 EAK89135.1 - 0.51 10.3 60.6 1.2 9.2 60.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 EAK89135.1 - 7.7 4.5 22.0 14 3.6 22.0 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CRAL_TRIO PF00650.20 EAK89136.1 - 1.8e-27 96.0 0.3 4e-27 94.9 0.3 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EAK89136.1 - 0.027 14.6 1.8 0.043 14.0 0.3 2.1 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain DUF61 PF01886.16 EAK89136.1 - 0.14 12.2 4.9 0.13 12.3 1.5 2.8 3 0 0 3 3 3 0 Protein of unknown function DUF61 Zip PF02535.22 EAK89136.1 - 10 5.3 10.6 19 4.3 10.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Sde2_N_Ubi PF13019.6 EAK89137.1 - 0.00088 19.1 4.4 0.0016 18.3 4.1 1.4 1 1 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain BORCS6 PF10157.9 EAK89137.1 - 0.015 15.6 2.0 0.029 14.6 2.0 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 FAST_1 PF06743.15 EAK89138.1 - 1.5e-05 24.9 4.1 0.084 12.8 0.1 5.0 3 2 2 5 5 5 3 FAST kinase-like protein, subdomain 1 Myb_DNA-bind_6 PF13921.6 EAK89138.1 - 0.046 14.0 0.2 0.18 12.1 0.2 2.0 1 0 0 1 1 1 0 Myb-like DNA-binding domain RMI2 PF16100.5 EAK89139.1 - 0.0083 15.9 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 tRNA_anti-codon PF01336.25 EAK89139.1 - 0.0094 15.9 0.3 0.023 14.7 0.3 1.7 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain PP2C PF00481.21 EAK89140.1 - 1.1e-19 71.1 0.0 1.1e-12 48.2 0.0 2.9 2 1 0 2 2 2 2 Protein phosphatase 2C Mob_Pre PF01076.19 EAK89140.1 - 0.017 14.9 0.2 0.017 14.9 0.2 1.8 2 0 0 2 2 2 0 Plasmid recombination enzyme GAF_2 PF13185.6 EAK89141.1 - 0.13 12.6 0.0 22 5.3 0.0 3.2 4 0 0 4 4 4 0 GAF domain DSPc PF00782.20 EAK89142.1 - 2.1e-26 92.3 0.0 9.6e-26 90.2 0.0 2.0 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EAK89142.1 - 0.005 16.4 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase zf-U1 PF06220.12 EAK89143.1 - 0.00037 20.2 1.3 0.00085 19.1 1.3 1.7 1 0 0 1 1 1 1 U1 zinc finger DUF3906 PF13046.6 EAK89143.1 - 0.19 11.9 1.0 0.49 10.5 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) COX4 PF02936.14 EAK89144.1 - 0.13 12.3 0.0 0.58 10.2 0.0 1.9 1 1 1 2 2 2 0 Cytochrome c oxidase subunit IV Tho1_MOS11_C PF18592.1 EAK89144.1 - 0.37 10.6 13.6 0.2 11.5 1.3 3.2 1 1 3 4 4 4 0 Tho1/MOS11 C-terminal domain LZ_Tnp_IS66 PF13007.7 EAK89144.1 - 0.48 11.2 9.5 51 4.7 6.0 4.1 2 1 0 2 2 2 0 Transposase C of IS166 homeodomain PFK PF00365.20 EAK89146.1 - 7.1e-51 173.2 3.4 1.5e-39 136.1 0.9 3.5 2 2 0 2 2 2 2 Phosphofructokinase SF-assemblin PF06705.11 EAK89147.1 - 5.1 6.4 11.8 0.46 9.8 2.1 3.4 3 1 0 3 3 3 0 SF-assemblin/beta giardin IQ PF00612.27 EAK89148.1 - 3.8e-09 35.5 8.2 0.00065 19.3 0.8 4.4 4 0 0 4 4 4 3 IQ calmodulin-binding motif AMPK1_CBM PF16561.5 EAK89149.1 - 4.4e-06 26.8 0.0 1.2e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase IQ PF00612.27 EAK89149.1 - 5.9e-05 22.5 7.2 0.69 9.9 1.7 3.5 3 0 0 3 3 3 3 IQ calmodulin-binding motif ubiquitin PF00240.23 EAK89150.1 - 1.5e-14 53.5 0.0 3e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EAK89150.1 - 2.5e-05 24.0 0.1 5e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EAK89150.1 - 0.09 13.2 0.0 0.36 11.3 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 EAK89150.1 - 0.1 13.2 0.0 0.38 11.3 0.0 2.0 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain NMD3 PF04981.13 EAK89151.1 - 6.9e-78 261.5 11.4 1.4e-77 260.5 11.4 1.5 1 0 0 1 1 1 1 NMD3 family DUF4834 PF16118.5 EAK89152.1 - 1.4 9.9 0.0 1.4 9.9 0.0 4.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) UBA_4 PF14555.6 EAK89154.1 - 9.9e-14 50.9 0.6 2e-13 49.9 0.6 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EAK89154.1 - 2.4e-06 27.6 0.0 6.1e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 UBX domain Ubiquitin_3 PF14836.6 EAK89154.1 - 0.0049 16.8 0.6 0.74 9.8 0.0 2.8 2 1 0 2 2 2 1 Ubiquitin-like domain TAP_C PF03943.13 EAK89154.1 - 0.0065 16.1 0.1 0.015 14.9 0.1 1.6 1 0 0 1 1 1 1 TAP C-terminal domain DarT PF14487.6 EAK89154.1 - 0.22 11.3 5.0 0.054 13.3 1.2 1.8 2 0 0 2 2 2 0 ssDNA thymidine ADP-ribosyltransferase, DarT Coiled-coil_56 PF09813.9 EAK89154.1 - 8 6.6 9.4 1.2 9.3 2.9 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 56 zf-C3HC4_3 PF13920.6 EAK89155.1 - 2.1e-14 53.1 10.8 4.1e-14 52.2 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EAK89155.1 - 2.5e-07 30.5 11.6 5.4e-07 29.4 11.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EAK89155.1 - 4e-06 27.0 14.6 6.9e-06 26.3 13.5 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EAK89155.1 - 0.00093 19.1 12.6 0.003 17.5 12.6 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Spindle_Spc25 PF08234.12 EAK89155.1 - 0.0096 16.1 0.7 0.029 14.6 0.3 2.0 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 zf-C3HC4_2 PF13923.6 EAK89155.1 - 0.21 11.5 15.6 0.17 11.7 13.7 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EAK89155.1 - 0.34 10.6 12.5 1.3 8.8 12.5 1.9 1 1 0 1 1 1 0 P-11 zinc finger DUF916 PF06030.12 EAK89155.1 - 1.1 9.4 4.9 1.7 8.7 1.8 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) RecR PF02132.15 EAK89155.1 - 8.6 6.0 15.0 19 4.9 8.1 2.6 2 0 0 2 2 2 0 RecR protein zf-RING_11 PF17123.5 EAK89155.1 - 9.9 6.0 12.2 1.2 9.0 0.9 3.8 4 0 0 4 4 4 0 RING-like zinc finger WhiA_N PF10298.9 EAK89157.1 - 0.048 13.7 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 WhiA N-terminal LAGLIDADG-like domain DUF3744 PF12558.8 EAK89157.1 - 0.077 13.8 0.0 0.56 11.0 0.0 2.3 2 0 0 2 2 2 0 ATP-binding cassette cobalt transporter ECD PF18432.1 EAK89157.1 - 0.084 12.8 0.6 0.18 11.8 0.1 1.8 2 0 0 2 2 2 0 Extracellular Cadherin domain HABP4_PAI-RBP1 PF04774.15 EAK89159.1 - 8.3e-05 23.4 8.5 8.3e-05 23.4 8.5 2.9 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family zf-CCCH_2 PF14608.6 EAK89160.1 - 2.3e-14 53.2 30.5 3.9e-05 24.0 2.1 3.5 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger PWI PF01480.17 EAK89160.1 - 2.5e-06 27.7 0.1 4.5e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 PWI domain zf-CCCH_4 PF18044.1 EAK89160.1 - 0.37 10.7 24.0 0.092 12.6 1.4 4.1 3 1 0 3 3 3 0 CCCH-type zinc finger DUF21 PF01595.20 EAK89161.1 - 6.3e-40 136.7 3.8 1.1e-39 136.0 3.8 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Osmo_CC PF08946.10 EAK89164.1 - 0.07 13.4 0.4 0.07 13.4 0.4 1.9 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Mod_r PF07200.13 EAK89165.1 - 0.0057 16.8 3.2 0.012 15.8 3.2 1.6 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein GnsAB_toxin PF08178.11 EAK89165.1 - 0.053 13.4 2.3 0.93 9.5 0.8 2.6 2 0 0 2 2 2 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system Uds1 PF15456.6 EAK89165.1 - 0.29 11.3 2.7 0.77 9.9 2.7 1.8 1 1 0 1 1 1 0 Up-regulated During Septation Hydin_ADK PF17213.3 EAK89166.1 - 1.2 9.3 10.6 3.1 8.0 10.6 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Longin PF13774.6 EAK89167.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Regulated-SNARE-like domain zf-C2H2_jaz PF12171.8 EAK89168.1 - 2e-06 27.9 0.5 5.2e-06 26.6 0.5 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EAK89168.1 - 1.1e-05 25.6 1.9 2.8e-05 24.3 1.9 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EAK89168.1 - 0.011 16.5 0.2 0.026 15.3 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-DBF PF07535.12 EAK89168.1 - 0.046 13.8 0.1 0.099 12.8 0.1 1.5 1 0 0 1 1 1 0 DBF zinc finger Ub-RnfH PF03658.14 EAK89168.1 - 0.097 13.1 0.1 0.33 11.3 0.1 1.9 1 1 0 1 1 1 0 RnfH family Ubiquitin zf-C2H2 PF00096.26 EAK89168.1 - 0.12 12.9 0.5 0.26 11.8 0.5 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type DA1-like PF12315.8 EAK89168.1 - 0.21 10.9 3.9 0.087 12.2 0.3 1.9 2 0 0 2 2 2 0 Protein DA1 Vps39_2 PF10367.9 EAK89169.1 - 3.2e-20 72.6 0.4 1.4e-19 70.5 0.4 2.2 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EAK89169.1 - 6.5e-07 29.2 0.7 3.9e-06 26.7 0.1 2.3 2 0 0 2 2 2 1 CNH domain DUF1340 PF07067.11 EAK89170.1 - 0.031 13.7 1.3 0.035 13.5 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1340) HHA PF05321.11 EAK89170.1 - 0.19 12.1 0.4 1.5 9.2 0.0 2.3 1 1 2 3 3 3 0 Haemolysin expression modulating protein SHNi-TPR PF10516.9 EAK89171.1 - 0.00013 21.3 0.1 0.00095 18.6 0.1 2.4 2 0 0 2 2 2 1 SHNi-TPR TPR_2 PF07719.17 EAK89171.1 - 0.00039 20.3 0.1 17 5.8 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Apt1 PF10351.9 EAK89171.1 - 0.00058 18.8 9.9 0.0011 18.0 9.9 1.5 1 0 0 1 1 1 1 Golgi-body localisation protein domain Pkinase_fungal PF17667.1 EAK89171.1 - 0.054 12.3 1.4 0.081 11.7 1.4 1.2 1 0 0 1 1 1 0 Fungal protein kinase TPR_12 PF13424.6 EAK89171.1 - 0.064 13.6 0.0 0.25 11.7 0.0 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat DUF357 PF04010.13 EAK89171.1 - 0.064 13.3 2.0 6.9 6.8 0.5 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF357) AF-4 PF05110.13 EAK89171.1 - 0.065 11.3 26.7 0.11 10.6 26.7 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4614 PF15391.6 EAK89171.1 - 0.077 13.0 20.1 0.17 11.9 20.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CCDC24 PF15669.5 EAK89171.1 - 0.23 11.3 9.0 0.57 10.0 9.0 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PAP1 PF08601.10 EAK89171.1 - 0.99 9.1 23.9 1.8 8.2 23.9 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 BUD22 PF09073.10 EAK89171.1 - 1.1 8.6 20.5 1.9 7.7 20.5 1.3 1 0 0 1 1 1 0 BUD22 CDK2AP PF09806.9 EAK89171.1 - 2.2 8.3 11.4 0.17 11.9 6.3 1.7 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Velvet PF11754.8 EAK89171.1 - 3.5 7.5 12.2 6 6.7 11.6 1.4 1 1 0 1 1 1 0 Velvet factor Gti1_Pac2 PF09729.9 EAK89171.1 - 4.6 7.3 14.8 0.18 11.9 8.1 2.0 2 0 0 2 2 2 0 Gti1/Pac2 family RAP1 PF07218.11 EAK89171.1 - 7.7 4.7 24.8 13 3.9 24.8 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1635 PF07795.11 EAK89171.1 - 9 6.1 15.0 27 4.5 15.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF1149 PF06619.11 EAK89173.1 - 0.95 9.8 8.0 0.55 10.5 6.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1149) Collectrin PF16959.5 EAK89175.1 - 0.18 11.6 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Renal amino acid transporter CNDH2_C PF16858.5 EAK89176.1 - 3e-31 109.4 3.4 3e-31 109.4 3.4 3.5 4 1 0 4 4 4 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.11 EAK89176.1 - 1.4e-18 67.1 9.5 1.8e-18 66.8 4.8 3.3 2 1 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal GvpG PF05120.12 EAK89176.1 - 0.82 9.7 5.3 0.7 9.9 0.8 3.1 4 0 0 4 4 4 0 Gas vesicle protein G CAML PF14963.6 EAK89178.1 - 0.038 14.1 6.9 0.028 14.5 4.1 2.1 1 1 1 2 2 2 0 Calcium signal-modulating cyclophilin ligand Rad60-SLD PF11976.8 EAK89179.1 - 8.7e-08 31.9 0.7 2.9e-07 30.2 0.7 1.9 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Pox_Ag35 PF03286.14 EAK89179.1 - 0.24 11.2 10.8 0.14 11.9 8.9 1.5 1 1 1 2 2 2 0 Pox virus Ag35 surface protein SWIB PF02201.18 EAK89182.1 - 1.5e-14 53.6 0.1 3.6e-14 52.4 0.1 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain Ribosomal_L29 PF00831.23 EAK89183.1 - 1.2e-17 63.6 1.8 1.2e-17 63.6 1.8 2.2 2 1 0 2 2 2 1 Ribosomal L29 protein WD40_alt PF14077.6 EAK89183.1 - 0.13 12.1 0.7 0.28 11.1 0.7 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Podoplanin PF05808.11 EAK89184.1 - 0.00066 19.8 0.0 0.00085 19.5 0.0 1.1 1 0 0 1 1 1 1 Podoplanin TrbL PF04610.14 EAK89184.1 - 0.0012 18.7 0.2 0.0018 18.1 0.2 1.2 1 0 0 1 1 1 1 TrbL/VirB6 plasmid conjugal transfer protein RIFIN PF02009.16 EAK89184.1 - 0.01 15.8 0.4 0.011 15.6 0.4 1.1 1 0 0 1 1 1 1 Rifin E1-E2_ATPase PF00122.20 EAK89184.1 - 0.011 15.3 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 E1-E2 ATPase DUF4690 PF15756.5 EAK89184.1 - 0.031 14.9 0.6 0.052 14.1 0.4 1.5 1 1 1 2 2 2 0 Small Novel Rich in Cartilage Phage_Coat_Gp8 PF05371.12 EAK89184.1 - 0.038 13.8 0.2 0.067 13.0 0.2 1.4 1 0 0 1 1 1 0 Phage major coat protein, Gp8 LRRC37AB_C PF14914.6 EAK89184.1 - 0.16 11.9 4.7 0.44 10.5 4.7 1.8 1 1 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain T2SSF PF00482.23 EAK89184.1 - 0.18 11.8 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F CYYR1 PF10873.8 EAK89184.1 - 0.56 10.7 7.1 1 9.8 7.1 1.4 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Shisa PF13908.6 EAK89184.1 - 1.3 9.2 12.3 3.4 7.9 12.3 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DAG1 PF05454.11 EAK89184.1 - 5 6.4 10.3 1.9 7.8 6.8 1.6 1 1 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) HtaA PF04213.13 EAK89185.1 - 0.11 13.0 0.6 0.42 11.1 0.1 2.3 2 1 1 3 3 3 0 Htaa PIH1_CS PF18201.1 EAK89185.1 - 0.41 11.1 4.8 0.29 11.6 1.9 2.3 2 0 0 2 2 2 0 PIH1 CS-like domain UPF0086 PF01868.16 EAK89186.1 - 1.9e-25 88.6 0.2 9.9e-25 86.3 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function UPF0086 DUF2458 PF10454.9 EAK89186.1 - 0.11 12.2 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Peptidase_C48 PF02902.19 EAK89188.1 - 5.1e-20 72.2 7.3 1.3e-19 70.9 4.3 2.6 1 1 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain ATG16 PF08614.11 EAK89189.1 - 0.0043 17.3 2.3 0.0053 17.0 2.3 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 EAK89189.1 - 0.0055 17.2 3.5 0.0077 16.8 3.5 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region MPS2 PF17060.5 EAK89189.1 - 0.011 15.0 2.3 0.013 14.8 2.3 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF3053 PF11254.8 EAK89189.1 - 0.012 15.2 1.6 0.016 14.8 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) Laminin_II PF06009.12 EAK89189.1 - 0.028 14.5 1.6 0.039 14.0 1.6 1.2 1 0 0 1 1 1 0 Laminin Domain II Atg14 PF10186.9 EAK89189.1 - 0.034 13.3 3.2 0.041 13.0 3.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Serine_rich PF08824.10 EAK89189.1 - 0.054 13.5 2.2 0.075 13.0 2.2 1.1 1 0 0 1 1 1 0 Serine rich protein interaction domain DUF2935 PF11155.8 EAK89189.1 - 0.071 13.4 0.9 0.1 12.9 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) DUF3450 PF11932.8 EAK89189.1 - 0.075 12.3 3.4 0.1 11.9 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PCRF PF03462.18 EAK89189.1 - 0.084 12.7 3.1 0.12 12.3 3.1 1.1 1 0 0 1 1 1 0 PCRF domain DASH_Spc34 PF08657.10 EAK89189.1 - 0.15 11.8 4.2 0.22 11.3 4.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 DUF1664 PF07889.12 EAK89189.1 - 0.16 12.0 3.5 0.23 11.5 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) YabA PF06156.13 EAK89189.1 - 0.24 12.1 3.8 0.19 12.4 1.1 2.0 1 1 1 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 EAK89189.1 - 0.3 11.6 7.8 0.5 10.8 7.8 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Swi5 PF07061.11 EAK89189.1 - 0.33 11.1 6.0 0.4 10.8 0.7 2.4 1 1 1 2 2 2 0 Swi5 CREPT PF16566.5 EAK89189.1 - 0.34 11.1 5.5 0.59 10.3 5.5 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour APC_N_CC PF16689.5 EAK89189.1 - 0.44 10.7 6.7 1.8 8.7 5.2 2.3 1 1 1 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain SHNi-TPR PF10516.9 EAK89190.1 - 0.11 12.0 0.4 0.2 11.1 0.4 1.4 1 0 0 1 1 1 0 SHNi-TPR DUF2085 PF09858.9 EAK89190.1 - 8.8 6.9 10.8 1.1 9.8 0.3 3.2 2 1 1 3 3 3 0 Predicted membrane protein (DUF2085) Hydrolase_4 PF12146.8 EAK89191.1 - 9.6e-16 57.8 0.0 2.5e-10 40.0 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK89191.1 - 8.9e-10 38.6 0.2 9.5e-06 25.4 0.2 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 EAK89191.1 - 4.1e-09 35.6 0.1 0.027 13.1 0.0 3.1 2 1 1 3 3 3 3 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 EAK89191.1 - 3.4e-06 27.8 0.0 8.2e-06 26.6 0.0 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF1057 PF06342.12 EAK89191.1 - 0.00032 19.9 0.0 0.0006 18.9 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Peptidase_S9 PF00326.21 EAK89191.1 - 0.00047 19.7 0.0 0.002 17.7 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EAK89191.1 - 0.0005 19.8 0.1 0.0059 16.3 0.0 2.3 2 0 0 2 2 2 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 EAK89191.1 - 0.00057 19.9 0.0 1.1 9.1 0.0 2.3 1 1 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EAK89191.1 - 0.0012 18.5 0.0 0.015 14.9 0.0 2.3 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EAK89191.1 - 0.024 14.4 0.1 4.1 7.2 0.0 3.1 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 EAK89191.1 - 0.05 13.5 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Ins145_P3_rec PF08709.11 EAK89191.1 - 0.087 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor LIDHydrolase PF10230.9 EAK89191.1 - 0.097 12.2 0.6 0.22 11.0 0.2 1.8 2 1 0 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 EAK89191.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold NAGLU_N PF12971.7 EAK89192.1 - 0.08 12.7 0.1 0.54 10.1 0.1 2.5 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain DUF2122 PF09895.9 EAK89193.1 - 2.3 8.6 4.6 13 6.3 0.1 3.6 2 0 0 2 2 2 0 RecB-family nuclease (DUF2122) ABC_tran PF00005.27 EAK89194.1 - 4.3e-20 72.6 0.4 2e-17 64.0 0.1 3.0 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EAK89194.1 - 5.7e-10 39.3 42.2 5.9e-08 32.7 18.9 2.8 2 1 0 2 2 2 2 ABC transporter transmembrane region GST_C_3 PF14497.6 EAK89195.1 - 0.034 14.3 0.0 0.085 13.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EAK89195.1 - 0.055 13.7 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ILEI PF15711.5 EAK89195.1 - 0.071 13.6 0.5 0.18 12.3 0.0 2.0 2 0 0 2 2 2 0 Interleukin-like EMT inducer SRC-1 PF08832.10 EAK89196.1 - 0.028 15.5 3.1 0.083 14.0 3.1 1.8 1 0 0 1 1 1 0 Steroid receptor coactivator AF-4 PF05110.13 EAK89196.1 - 1.4 6.9 15.3 1.9 6.5 15.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 EAK89196.1 - 3.7 6.0 9.2 5 5.6 9.2 1.1 1 0 0 1 1 1 0 Macoilin family AMP-binding PF00501.28 EAK89199.1 - 3.6e-68 230.1 0.0 5.5e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF973 PF06157.11 EAK89200.1 - 2.7 6.9 8.3 4.8 6.2 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF973) PH_3 PF14593.6 EAK89201.1 - 0.064 13.4 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 PH domain DUF900 PF05990.12 EAK89202.1 - 8.5e-24 84.4 0.0 1.7e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) ATPase PF06745.13 EAK89203.1 - 2.1e-05 24.0 1.4 0.0001 21.8 0.1 2.4 2 0 0 2 2 2 1 KaiC MFS_1 PF07690.16 EAK89206.1 - 1.5e-11 43.9 41.3 4.1e-09 35.8 23.3 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EAK89207.1 - 1.1e-05 24.5 36.5 1.1e-05 24.5 36.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily PAN_1 PF00024.26 EAK89209.1 - 6e-10 38.9 10.9 0.00016 21.5 4.2 3.4 3 0 0 3 3 3 2 PAN domain PAN_4 PF14295.6 EAK89209.1 - 7.2e-07 29.0 7.1 0.00021 21.1 0.7 3.6 3 0 0 3 3 3 2 PAN domain Prot_inhib_II PF02428.15 EAK89209.1 - 2.9 8.4 8.6 9.8 6.7 1.0 2.8 2 0 0 2 2 2 0 Potato type II proteinase inhibitor family TPT PF03151.16 EAK89210.1 - 1.3e-18 67.4 14.7 1.6e-18 67.1 14.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EAK89210.1 - 2.5e-05 24.5 6.5 2.5e-05 24.5 6.5 2.3 2 0 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 EAK89211.1 - 1.9e-08 34.0 15.4 2.6e-08 33.6 15.4 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EAK89211.1 - 0.0021 18.3 2.4 0.0021 18.3 2.4 3.0 3 1 0 3 3 3 2 EamA-like transporter family TMEM234 PF10639.9 EAK89211.1 - 0.0044 17.0 3.2 0.0064 16.5 0.6 2.6 3 0 0 3 3 3 1 Putative transmembrane family 234 PUNUT PF16913.5 EAK89211.1 - 0.0067 15.7 6.1 0.0067 15.7 6.1 2.9 2 1 1 3 3 3 1 Purine nucleobase transmembrane transport TPT PF03151.16 EAK89212.1 - 7.2e-16 58.4 20.4 9.5e-16 58.0 20.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family PUNUT PF16913.5 EAK89212.1 - 0.0011 18.3 17.1 0.0074 15.6 10.2 2.2 2 0 0 2 2 2 2 Purine nucleobase transmembrane transport EamA PF00892.20 EAK89212.1 - 0.0032 17.6 30.0 0.01 16.0 12.7 2.7 2 1 0 2 2 2 2 EamA-like transporter family Aa_trans PF01490.18 EAK89215.1 - 9.6e-22 77.2 30.9 1.5e-17 63.4 14.5 2.5 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein Orf78 PF06024.12 EAK89215.1 - 0.0087 16.3 1.4 0.12 12.6 0.1 3.0 2 1 0 2 2 2 1 Orf78 (ac78) SieB PF14163.6 EAK89215.1 - 1.7 8.1 7.4 6.1 6.3 0.9 3.2 3 1 0 3 3 3 0 Super-infection exclusion protein B GSHPx PF00255.19 EAK89216.1 - 2.1e-26 91.6 0.0 5.2e-26 90.3 0.0 1.6 2 0 0 2 2 2 1 Glutathione peroxidase AhpC-TSA PF00578.21 EAK89216.1 - 8e-08 32.2 0.0 3.8e-06 26.8 0.0 2.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EAK89216.1 - 0.0018 18.0 0.0 0.0066 16.2 0.0 1.8 1 1 0 1 1 1 1 Redoxin mRNA_triPase PF02940.15 EAK89217.1 - 2.2e-11 43.9 2.1 3.6e-11 43.2 2.1 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain EphA2_TM PF14575.6 EAK89218.1 - 0.0034 18.2 0.4 0.0098 16.8 0.0 2.0 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain LRRC37AB_C PF14914.6 EAK89218.1 - 0.0056 16.6 0.0 0.0056 16.6 0.0 2.4 2 0 0 2 2 2 1 LRRC37A/B like protein 1 C-terminal domain WBP-1 PF11669.8 EAK89218.1 - 0.066 13.9 0.5 0.34 11.6 0.0 2.3 2 0 0 2 2 2 0 WW domain-binding protein 1 Tmemb_9 PF05434.11 EAK89218.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.5 2 1 0 2 2 2 0 TMEM9 TMEM154 PF15102.6 EAK89218.1 - 0.12 12.3 0.2 0.12 12.3 0.2 3.9 2 1 1 3 3 2 0 TMEM154 protein family SKG6 PF08693.10 EAK89218.1 - 0.17 11.3 4.9 0.63 9.5 4.9 2.0 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TMIE PF16038.5 EAK89218.1 - 0.18 11.6 0.4 0.44 10.4 0.4 1.7 1 0 0 1 1 1 0 TMIE protein Shisa PF13908.6 EAK89218.1 - 0.38 11.0 13.9 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF2407_C PF13373.6 EAK89218.1 - 0.39 10.9 5.6 4.5 7.4 5.6 2.7 1 1 0 1 1 1 0 DUF2407 C-terminal domain Orf78 PF06024.12 EAK89218.1 - 0.61 10.4 0.0 0.61 10.4 0.0 3.0 2 2 0 2 2 2 0 Orf78 (ac78) Comm PF15957.5 EAK89218.1 - 0.7 10.3 0.0 0.7 10.3 0.0 2.5 2 1 0 2 2 1 0 Commissureless Pneumo_att_G PF05539.11 EAK89218.1 - 0.9 9.1 30.1 1.5 8.4 30.1 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Glycophorin_A PF01102.18 EAK89218.1 - 0.95 9.7 0.0 0.95 9.7 0.0 3.4 2 1 0 2 2 1 0 Glycophorin A VPS13_C PF16909.5 EAK89219.1 - 5.2e-49 166.4 18.5 7.3e-46 156.2 9.1 4.0 3 1 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EAK89219.1 - 3.5e-25 88.4 0.2 1.1e-23 83.6 0.1 3.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EAK89219.1 - 1.1e-13 51.5 0.2 2.2e-09 37.5 0.0 3.0 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal ATG_C PF09333.11 EAK89219.1 - 4.5e-07 30.1 0.1 1.5e-06 28.5 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Sec1 PF00995.23 EAK89220.1 - 5.6e-07 29.2 17.2 0.0019 17.5 4.8 2.5 2 1 0 2 2 2 2 Sec1 family ABC_membrane PF00664.23 EAK89221.1 - 4.7e-25 88.8 42.0 1.9e-18 67.1 21.4 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EAK89221.1 - 1.2e-24 87.3 0.0 1.2e-11 45.2 0.0 3.0 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EAK89221.1 - 9.3e-07 28.5 0.6 0.0033 17.1 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SSE PF00437.20 EAK89221.1 - 7.4e-06 25.2 0.0 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_21 PF13304.6 EAK89221.1 - 3.9e-05 23.6 0.2 0.4 10.5 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EAK89221.1 - 0.00035 20.5 1.6 0.38 10.7 0.1 2.8 2 1 0 2 2 2 2 RsgA GTPase FtsK_SpoIIIE PF01580.18 EAK89221.1 - 0.00048 19.6 4.1 0.1 12.0 0.0 3.1 3 0 0 3 3 3 2 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EAK89221.1 - 0.00055 20.0 5.3 0.083 13.0 0.2 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EAK89221.1 - 0.00082 19.8 0.0 0.47 10.8 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EAK89221.1 - 0.0013 18.8 2.2 0.19 11.8 0.2 3.0 2 0 0 2 2 2 1 Dynamin family AAA_22 PF13401.6 EAK89221.1 - 0.0014 18.9 3.8 0.92 9.8 0.5 3.3 2 1 0 2 2 2 2 AAA domain NACHT PF05729.12 EAK89221.1 - 0.0016 18.3 0.1 2.6 7.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_7 PF12775.7 EAK89221.1 - 0.0028 17.2 0.5 0.84 9.1 0.1 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region Pox_A32 PF04665.12 EAK89221.1 - 0.0028 17.1 1.5 0.13 11.7 0.1 2.6 2 0 0 2 2 2 1 Poxvirus A32 protein IstB_IS21 PF01695.17 EAK89221.1 - 0.0029 17.4 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein MobB PF03205.14 EAK89221.1 - 0.0069 16.3 0.6 2.6 7.9 0.2 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 EAK89221.1 - 0.0087 15.7 0.0 0.5 9.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EAK89221.1 - 0.011 15.4 0.0 0.94 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EAK89221.1 - 0.015 15.4 0.0 8.9 6.5 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EAK89221.1 - 0.018 14.8 0.3 1.8 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EAK89221.1 - 0.034 13.6 3.4 1.2 8.5 0.2 3.3 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 EAK89221.1 - 0.053 13.1 2.7 3 7.4 0.4 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 EAK89221.1 - 0.1 11.5 0.3 5.6 5.8 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 EAK89221.1 - 0.13 12.8 0.1 19 5.8 0.0 3.6 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EAK89221.1 - 0.29 11.3 3.0 20 5.4 0.1 3.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EAK89221.1 - 1.2 8.9 3.7 4.7 6.9 0.1 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 EAK89221.1 - 4.5 7.3 15.3 1.2 9.2 0.6 3.7 3 1 1 4 4 4 0 Helicase HerA, central domain DEAD PF00270.29 EAK89223.1 - 2.1e-19 70.0 0.0 8.2e-19 68.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89223.1 - 5e-14 52.6 0.0 5e-14 52.6 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EAK89223.1 - 0.00021 22.0 2.0 0.00021 22.0 2.0 3.7 3 1 1 4 4 4 1 RecQ zinc-binding CAF1 PF04857.20 EAK89226.1 - 2.6e-23 82.7 8.2 1.7e-11 43.9 1.7 2.4 2 1 0 2 2 2 2 CAF1 family ribonuclease RNase_T PF00929.24 EAK89226.1 - 0.071 13.6 0.0 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 Exonuclease Sdh_cyt PF01127.22 EAK89227.1 - 0.066 13.2 6.4 0.79 9.8 6.4 2.4 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Lig_chan PF00060.26 EAK89227.1 - 1.8 8.4 4.7 3.2 7.6 0.3 2.4 2 0 0 2 2 2 0 Ligand-gated ion channel RCC1 PF00415.18 EAK89228.1 - 8.6e-110 359.3 40.4 3.2e-12 46.9 0.5 13.5 13 1 0 13 13 13 11 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EAK89228.1 - 1.3e-45 152.3 78.2 1.6e-07 30.9 0.2 14.0 13 1 0 13 13 13 11 Regulator of chromosome condensation (RCC1) repeat RasGAP_C PF03836.15 EAK89228.1 - 0.044 13.9 2.8 0.17 12.0 2.7 2.0 1 1 0 1 1 1 0 RasGAP C-terminus NTF2 PF02136.20 EAK89229.1 - 1.5e-12 48.1 0.6 9.6e-12 45.5 0.0 2.3 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain Mucin PF01456.17 EAK89229.1 - 0.092 12.7 13.8 0.024 14.7 8.8 2.2 2 1 0 2 2 2 0 Mucin-like glycoprotein eIF2_C PF09173.11 EAK89230.1 - 1.1e-30 105.6 0.0 2.4e-30 104.6 0.0 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EAK89230.1 - 1.7e-23 83.2 0.7 2.1e-22 79.7 0.7 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EAK89230.1 - 2.5e-11 43.8 1.3 9.1e-11 42.0 0.4 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EAK89230.1 - 0.005 16.9 0.0 0.0094 16.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dak1_2 PF13684.6 EAK89230.1 - 0.011 14.9 0.3 0.017 14.2 0.3 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family RsgA_GTPase PF03193.16 EAK89230.1 - 0.012 15.5 0.4 0.074 12.9 0.1 2.0 2 0 0 2 2 2 0 RsgA GTPase Metallophos PF00149.28 EAK89231.1 - 5.2e-08 33.6 0.8 1.2e-07 32.5 0.8 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EAK89231.1 - 0.051 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain DBR1 PF05011.13 EAK89231.1 - 0.057 13.8 0.2 0.11 12.9 0.0 1.5 2 0 0 2 2 2 0 Lariat debranching enzyme, C-terminal domain Peptidase_M16 PF00675.20 EAK89232.1 - 3.9e-28 98.3 1.8 2.6e-27 95.7 0.2 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK89232.1 - 5.2e-14 52.7 0.8 2.7e-08 34.0 0.1 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK89233.1 - 4.6e-12 46.2 0.0 4.6e-12 46.2 0.0 2.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAK89233.1 - 7.5e-08 32.6 0.2 2.7e-07 30.8 0.2 2.0 1 0 0 1 1 1 1 Peptidase M16 inactive domain TFIIF_alpha PF05793.12 EAK89233.1 - 0.6 8.6 18.0 0.91 8.0 18.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 EAK89233.1 - 1 7.6 13.1 1.5 7.0 8.6 2.1 2 0 0 2 2 2 0 CDC45-like protein Atrophin-1 PF03154.15 EAK89233.1 - 2.3 6.4 7.3 3.2 5.9 7.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family Roughex PF06020.11 EAK89233.1 - 3.1 6.8 11.2 7 5.6 11.2 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Cyclin_N PF00134.23 EAK89234.1 - 9.5e-27 93.3 1.1 1.4e-26 92.7 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EAK89234.1 - 0.0013 18.8 0.1 0.0029 17.7 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain AAA_18 PF13238.6 EAK89234.1 - 0.12 12.9 0.3 0.32 11.6 0.1 1.7 2 0 0 2 2 2 0 AAA domain Thioredoxin_7 PF13899.6 EAK89235.1 - 6.6e-10 39.0 0.0 1.4e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EAK89235.1 - 2.4e-07 30.4 0.1 6.3e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 UBA-like domain Sugar_tr PF00083.24 EAK89236.1 - 2.9e-50 171.5 23.6 3.5e-50 171.2 23.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EAK89236.1 - 6.2e-32 110.9 43.5 3.2e-25 88.8 22.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Bax1-I PF01027.20 EAK89237.1 - 7.2e-26 91.3 40.7 8.8e-26 91.0 40.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CSN8_PSD8_EIF3K PF10075.9 EAK89238.1 - 3.4e-32 111.4 0.2 8.9e-32 110.0 0.0 1.7 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF3865 PF12981.7 EAK89238.1 - 0.082 12.8 0.4 0.14 12.0 0.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3865) DmpG_comm PF07836.11 EAK89238.1 - 0.12 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 DmpG-like communication domain PA28_alpha PF02251.18 EAK89238.1 - 0.46 10.6 3.5 16 5.6 0.1 3.2 3 0 0 3 3 3 0 Proteasome activator pa28 alpha subunit Ribosomal_L27A PF00828.19 EAK89239.1 - 2.1e-21 76.9 0.0 3.2e-21 76.3 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF5026 PF16429.5 EAK89239.1 - 0.2 11.8 0.5 0.31 11.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5026) RTC4 PF14474.6 EAK89239.1 - 0.31 11.2 1.0 0.33 11.1 0.2 1.7 2 1 0 2 2 2 0 RTC4-like domain Ribosomal_L7Ae PF01248.26 EAK89240.1 - 1.9e-22 78.8 0.0 2.1e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DPBB_1 PF03330.18 EAK89240.1 - 0.0022 18.3 0.3 0.49 10.7 0.1 2.1 1 1 1 2 2 2 2 Lytic transglycolase Nuf2 PF03800.14 EAK89242.1 - 1.1e-25 90.3 0.0 1.1e-25 90.3 0.0 2.8 2 2 1 3 3 3 1 Nuf2 family TACC_C PF05010.14 EAK89242.1 - 0.0064 16.3 25.3 0.0064 16.3 25.3 3.6 1 1 2 3 3 3 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2379 PF09543.10 EAK89242.1 - 0.009 16.2 0.8 0.009 16.2 0.8 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2379) Filament PF00038.21 EAK89242.1 - 0.11 12.1 55.1 0.092 12.3 12.4 3.9 1 1 3 4 4 4 0 Intermediate filament protein DHR10 PF18595.1 EAK89242.1 - 2.4 8.3 53.5 0.79 9.8 19.4 4.2 1 1 2 4 4 4 0 Designed helical repeat protein 10 domain UPF0242 PF06785.11 EAK89242.1 - 8.7 6.4 68.4 67 3.5 29.6 4.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DKCLD PF08068.12 EAK89243.1 - 2.9e-32 110.5 0.2 2.7e-31 107.4 0.3 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 EAK89243.1 - 1.6e-22 80.5 0.1 3.4e-19 69.7 0.1 3.5 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EAK89243.1 - 6.4e-21 74.3 1.3 1.1e-20 73.5 1.3 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EAK89243.1 - 6.6e-20 70.8 2.8 1.5e-19 69.7 2.8 1.7 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EAK89243.1 - 0.021 15.1 0.1 0.074 13.3 0.1 2.0 1 0 0 1 1 1 0 UPF0113 PUA domain SR-25 PF10500.9 EAK89243.1 - 0.15 11.7 47.4 0.23 11.1 47.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Clat_adaptor_s PF01217.20 EAK89244.1 - 3.6e-20 72.3 3.3 4.4e-20 72.1 3.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1827 PF08860.10 EAK89244.1 - 0.0062 16.8 0.0 0.014 15.7 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1827) Ribosomal_L19e PF01280.20 EAK89245.1 - 6e-57 191.8 11.1 8.7e-57 191.2 11.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L19e HSP90 PF00183.18 EAK89246.1 - 7.4e-229 760.9 26.8 9.3e-229 760.6 26.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EAK89246.1 - 4.7e-16 59.3 0.3 8.9e-16 58.4 0.3 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EAK89246.1 - 3.9e-11 42.9 0.3 1e-10 41.6 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 EAK89246.1 - 0.046 13.7 0.1 0.15 12.1 0.1 1.9 1 0 0 1 1 1 0 Tumour suppressor protein DUF4032 PF13224.6 EAK89246.1 - 0.088 12.7 0.0 19 5.1 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4032) Ribosomal_S20p PF01649.18 EAK89246.1 - 0.66 10.7 3.8 0.47 11.1 0.4 2.6 3 0 0 3 3 3 0 Ribosomal protein S20 EF-hand_1 PF00036.32 EAK89247.1 - 8.3e-05 21.9 0.4 0.12 12.0 0.0 3.5 3 1 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EAK89247.1 - 0.00012 22.4 0.1 0.0021 18.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EAK89247.1 - 0.0021 17.8 2.7 0.11 12.5 0.0 3.4 4 1 1 5 5 5 1 EF-hand domain EF-hand_9 PF14658.6 EAK89247.1 - 0.076 13.4 0.0 0.4 11.1 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain TerB PF05099.13 EAK89247.1 - 0.088 12.8 0.0 0.48 10.4 0.0 1.9 1 1 0 1 1 1 0 Tellurite resistance protein TerB MBF1 PF08523.10 EAK89248.1 - 3.8e-19 68.9 0.9 3.8e-19 68.9 0.9 1.7 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EAK89248.1 - 6.5e-13 48.5 0.1 1.2e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EAK89248.1 - 2.8e-05 24.4 0.0 4.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EAK89248.1 - 0.00021 21.2 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 EAK89248.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_37 PF13744.6 EAK89248.1 - 0.025 14.5 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4205 PF13898.6 EAK89249.1 - 9.3e-46 156.3 0.5 1e-44 152.9 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4205) EF-hand_7 PF13499.6 EAK89249.1 - 0.0083 16.6 3.3 0.07 13.6 0.2 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EAK89249.1 - 0.009 15.9 4.2 0.077 13.0 0.5 4.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 EAK89249.1 - 0.045 13.3 0.1 0.3 10.7 0.1 2.5 1 0 0 1 1 1 0 EF hand Tubulin_3 PF14881.6 EAK89249.1 - 0.074 12.7 0.2 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 Tubulin domain UIM PF02809.20 EAK89249.1 - 6.5 6.9 5.3 1.8 8.7 1.8 2.1 2 0 0 2 2 2 0 Ubiquitin interaction motif BolA PF01722.18 EAK89250.1 - 6.6e-14 51.9 0.0 1.1e-13 51.2 0.0 1.4 1 1 0 1 1 1 1 BolA-like protein DUF1870 PF08965.10 EAK89250.1 - 0.076 13.0 0.1 0.15 12.1 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) Peptidase_M18 PF02127.15 EAK89251.1 - 1e-123 413.4 0.1 1.7e-123 412.6 0.1 1.3 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EAK89251.1 - 7.9e-10 38.2 0.0 8.5e-07 28.3 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Glyco_transf_22 PF03901.17 EAK89253.1 - 5.7e-59 200.4 56.0 1.4e-58 199.1 56.0 1.6 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family Rep_fac-A_3 PF08661.11 EAK89254.1 - 1.2e-16 60.9 0.0 1.4e-16 60.7 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF150_C PF17384.2 EAK89254.1 - 0.13 12.4 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain DEAD PF00270.29 EAK89255.1 - 1.3e-30 106.4 0.0 2.5e-30 105.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89255.1 - 1.3e-23 83.5 0.1 8.6e-23 80.8 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89255.1 - 4.8e-07 29.9 0.0 1.4e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit tRNA-synt_2d PF01409.20 EAK89256.1 - 1.1e-84 283.8 0.0 1.5e-84 283.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 EAK89256.1 - 6.2e-11 41.9 0.3 1.8e-10 40.4 0.1 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 EAK89256.1 - 4.9e-09 36.3 0.5 6.2e-08 32.8 0.0 2.9 3 0 0 3 3 3 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EAK89256.1 - 5.4e-06 26.0 0.0 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 EAK89256.1 - 0.00082 18.5 0.0 0.011 14.9 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) S10_plectin PF03501.15 EAK89256.1 - 0.005 16.9 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 Plectin/S10 domain AAA PF00004.29 EAK89257.1 - 5.9e-14 52.6 0.1 2e-13 50.9 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EAK89257.1 - 7.1e-13 48.8 0.0 3.8e-12 46.4 0.0 2.4 2 1 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EAK89257.1 - 6e-12 45.6 0.8 1.4e-11 44.4 0.8 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EAK89257.1 - 3.7e-10 40.0 0.1 8e-10 38.9 0.1 1.6 2 0 0 2 2 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EAK89257.1 - 7.2e-08 32.4 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EAK89257.1 - 1.3e-07 32.0 0.0 2.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EAK89257.1 - 4.2e-06 26.7 3.7 0.0014 18.5 0.1 2.3 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.6 EAK89257.1 - 2.9e-05 24.5 0.0 0.00017 22.0 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EAK89257.1 - 0.00028 20.9 0.1 0.0045 17.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EAK89257.1 - 0.00028 21.2 0.3 0.001 19.3 0.3 1.9 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EAK89257.1 - 0.0011 18.3 0.0 0.0017 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) PIF1 PF05970.14 EAK89257.1 - 0.0013 17.9 0.6 0.0092 15.2 0.5 1.9 1 1 0 1 1 1 1 PIF1-like helicase RuvB_N PF05496.12 EAK89257.1 - 0.0018 18.1 0.0 0.004 16.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 EAK89257.1 - 0.0019 18.2 0.0 0.0084 16.1 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EAK89257.1 - 0.003 17.4 0.5 0.02 14.7 0.5 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_assoc_2 PF16193.5 EAK89257.1 - 0.0041 17.4 0.0 0.012 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_3 PF07726.11 EAK89257.1 - 0.0046 16.8 0.1 0.019 14.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EAK89257.1 - 0.0056 16.2 0.0 0.0098 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region DNA_pol3_delta PF06144.13 EAK89257.1 - 0.0062 16.3 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF2075 PF09848.9 EAK89257.1 - 0.0081 15.4 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 EAK89257.1 - 0.015 15.8 0.2 0.022 15.2 0.2 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EAK89257.1 - 0.016 15.7 0.5 1.5 9.4 0.1 3.0 2 1 1 3 3 3 0 ABC transporter T2SSE PF00437.20 EAK89257.1 - 0.034 13.2 0.0 0.084 11.9 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 EAK89257.1 - 0.046 13.8 0.1 0.32 11.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EAK89257.1 - 0.053 12.9 0.1 0.13 11.6 0.1 1.8 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 EAK89257.1 - 0.064 12.4 0.0 0.095 11.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 EAK89257.1 - 0.084 12.6 0.1 1.2 8.8 0.0 2.4 3 0 0 3 3 3 0 Sigma-54 interaction domain Torsin PF06309.11 EAK89257.1 - 0.12 12.4 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Torsin AAA_28 PF13521.6 EAK89257.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain PLDc_2 PF13091.6 EAK89258.1 - 1.2e-33 115.8 2.1 6.2e-16 58.5 0.2 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EAK89258.1 - 7.3e-06 26.0 0.6 0.0032 17.6 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Chrome_Resist PF09828.9 EAK89258.1 - 0.01 16.3 0.2 0.023 15.1 0.2 1.6 1 1 0 1 1 1 0 Chromate resistance exported protein Pan3_PK PF18101.1 EAK89258.1 - 0.069 13.1 1.0 4.6 7.2 0.1 2.6 2 0 0 2 2 2 0 Pan3 Pseudokinase domain LRR_9 PF14580.6 EAK89259.1 - 6e-34 117.0 5.0 6e-34 117.0 5.0 1.9 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EAK89259.1 - 4.7e-09 36.4 28.9 0.0002 21.7 1.4 5.1 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EAK89259.1 - 4.2e-06 26.4 6.9 4.2e-06 26.4 6.9 4.2 2 1 3 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 EAK89259.1 - 0.28 11.9 9.9 6.9 7.6 0.4 4.6 3 2 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 EAK89259.1 - 0.34 11.1 6.7 11 6.3 0.3 3.9 3 0 0 3 3 3 0 Leucine Rich repeat NUFIP1 PF10453.9 EAK89260.1 - 0.002 17.9 0.6 0.012 15.4 0.6 2.5 1 1 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2_jaz PF12171.8 EAK89260.1 - 0.022 15.0 1.5 0.022 15.0 1.5 3.7 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding DUF523 PF04463.12 EAK89260.1 - 0.036 14.1 0.3 0.25 11.4 0.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF523) zf-C4pol PF14260.6 EAK89260.1 - 4.7 7.8 10.6 0.65 10.5 2.2 2.8 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta SPC22 PF04573.12 EAK89261.1 - 2.2e-35 121.6 1.5 2.6e-35 121.4 1.5 1.0 1 0 0 1 1 1 1 Signal peptidase subunit Runt PF00853.19 EAK89261.1 - 0.15 11.6 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Runt domain RNA_pol_Rpb1_5 PF04998.17 EAK89262.1 - 3e-101 338.4 0.3 6.3e-101 337.3 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EAK89262.1 - 8.1e-100 334.2 0.2 1.6e-99 333.2 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EAK89262.1 - 1.4e-74 249.9 0.0 2.8e-74 248.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EAK89262.1 - 6.5e-55 185.9 0.1 1.2e-54 185.0 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EAK89262.1 - 8.7e-45 152.5 0.3 2.9e-44 150.8 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EAK89262.1 - 2e-43 147.7 4.1 4.5e-43 146.5 4.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EAK89262.1 - 2.7e-37 127.0 0.1 1e-36 125.1 0.1 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EAK89262.1 - 1.2e-21 75.8 319.5 0.0027 18.0 11.4 21.5 11 4 12 25 25 25 19 RNA polymerase Rpb1 C-terminal repeat TFIIS_C PF01096.18 EAK89263.1 - 2.8e-14 52.7 15.8 2.9e-14 52.6 7.6 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 EAK89263.1 - 0.0029 17.7 6.5 4.6 7.4 0.1 4.3 4 0 0 4 4 4 1 Zinc ribbon domain PknG_rubred PF16919.5 EAK89263.1 - 0.053 13.7 0.3 0.79 9.9 0.1 2.3 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain IL31 PF15209.6 EAK89263.1 - 0.065 13.0 1.2 3.6 7.4 0.1 2.2 2 0 0 2 2 2 0 Interleukin 31 FAM163 PF15069.6 EAK89263.1 - 0.29 11.6 5.9 0.08 13.4 0.9 2.2 1 1 2 3 3 3 0 FAM163 family ADK_lid PF05191.14 EAK89263.1 - 0.3 11.1 5.6 7.9 6.6 0.1 2.7 2 1 0 2 2 2 0 Adenylate kinase, active site lid DNA_RNApol_7kD PF03604.13 EAK89263.1 - 0.92 9.2 0.0 0.92 9.2 0.0 3.7 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit Zn_Tnp_IS1595 PF12760.7 EAK89263.1 - 1.4 9.0 12.4 3.3 7.8 0.3 2.8 2 2 0 2 2 2 0 Transposase zinc-ribbon domain Myb_DNA-binding PF00249.31 EAK89264.1 - 2.5e-11 43.6 4.5 9.4e-11 41.7 1.4 3.0 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EAK89264.1 - 1e-09 38.5 0.5 1e-09 38.5 0.5 3.8 5 0 0 5 5 5 1 Myb-like DNA-binding domain Rap1a PF18602.1 EAK89264.1 - 0.07 13.5 0.1 0.24 11.8 0.1 1.8 2 0 0 2 2 2 0 Rap1a immunity proteins SANT_DAMP1_like PF16282.5 EAK89264.1 - 0.078 13.2 1.0 0.59 10.4 0.1 2.6 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_5 PF13873.6 EAK89264.1 - 0.74 9.9 6.8 12 6.0 0.3 4.1 5 0 0 5 5 5 0 Myb/SANT-like DNA-binding domain zf-CSL PF05207.13 EAK89265.1 - 4.5e-15 55.1 0.6 5.7e-15 54.8 0.6 1.2 1 0 0 1 1 1 1 CSL zinc finger Ribosomal_L37ae PF01780.19 EAK89266.1 - 5.3e-36 122.6 6.1 6e-36 122.4 6.1 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EAK89266.1 - 0.00031 20.7 4.6 0.00051 20.0 4.6 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Lar_restr_allev PF14354.6 EAK89266.1 - 0.0067 16.8 0.6 0.0087 16.4 0.6 1.4 1 0 0 1 1 1 1 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.10 EAK89266.1 - 0.011 15.4 2.6 0.38 10.5 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-RING_13 PF17977.1 EAK89266.1 - 0.016 15.3 4.1 0.023 14.8 4.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-H2C2_2 PF13465.6 EAK89266.1 - 0.016 15.6 2.5 0.15 12.5 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-BED PF02892.15 EAK89266.1 - 0.044 13.8 2.2 3.4 7.8 0.3 2.3 1 1 1 2 2 2 0 BED zinc finger Zn-ribbon_8 PF09723.10 EAK89266.1 - 0.068 13.3 1.2 0.37 10.9 0.6 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 EAK89266.1 - 0.1 12.9 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EAK89266.1 - 0.39 11.3 2.4 3.4 8.3 0.4 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EAK89266.1 - 1 10.4 3.1 6.3 7.9 1.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger UMP1 PF05348.11 EAK89267.1 - 6.5e-13 49.0 0.1 7.3e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 REPA_OB_2 PF16900.5 EAK89268.1 - 7e-26 90.0 0.2 8.8e-23 80.1 0.1 2.5 2 0 0 2 2 2 2 Replication protein A OB domain Rep_fac-A_C PF08646.10 EAK89268.1 - 1.5e-21 76.7 3.5 3.2e-21 75.6 3.5 1.6 1 0 0 1 1 1 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.25 EAK89268.1 - 7e-07 29.2 0.3 2.4e-05 24.2 0.1 2.9 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain DUF5088 PF17008.5 EAK89268.1 - 0.004 16.9 0.8 0.0096 15.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5088) SSB PF00436.25 EAK89268.1 - 0.008 16.2 0.2 6.5 6.9 0.0 2.9 2 1 0 2 2 2 2 Single-strand binding protein family DZR PF12773.7 EAK89268.1 - 0.85 9.7 3.1 0.68 10.0 0.6 1.6 1 1 1 2 2 2 0 Double zinc ribbon SprT-like PF10263.9 EAK89269.1 - 5.1e-28 97.2 0.1 9.1e-28 96.4 0.1 1.4 1 0 0 1 1 1 1 SprT-like family Nop PF01798.18 EAK89270.1 - 2.6e-83 279.0 0.1 3.7e-83 278.5 0.1 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EAK89270.1 - 4.3e-18 65.5 0.2 9.8e-18 64.3 0.2 1.7 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Ribosomal_S2 PF00318.20 EAK89271.1 - 5e-24 84.7 2.8 2.4e-13 49.8 0.4 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Pox_A22 PF04848.13 EAK89271.1 - 0.027 14.6 0.4 0.079 13.1 0.1 1.8 2 0 0 2 2 2 0 Poxvirus A22 protein zinc_ribbon_9 PF14369.6 EAK89272.1 - 3.8e-12 46.3 2.4 3.8e-12 46.3 2.4 2.3 2 0 0 2 2 2 1 zinc-ribbon zf-RING_2 PF13639.6 EAK89272.1 - 5.3e-11 42.7 5.2 5.3e-11 42.7 5.2 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EAK89272.1 - 2.2e-07 30.6 5.0 2.2e-07 30.6 5.0 2.9 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EAK89272.1 - 2.2e-07 31.0 6.1 2.2e-07 31.0 6.1 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EAK89272.1 - 4.1e-05 23.6 2.4 4.1e-05 23.6 2.4 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EAK89272.1 - 0.00011 21.9 2.7 0.00041 20.0 2.7 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EAK89272.1 - 0.00019 21.2 4.7 0.00019 21.2 4.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK89272.1 - 0.0011 19.0 4.8 0.0011 19.0 4.8 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAK89272.1 - 0.0071 16.3 17.2 0.0081 16.1 4.4 2.6 2 1 0 2 2 2 1 zinc-RING finger domain Zn-ribbon_8 PF09723.10 EAK89272.1 - 0.0089 16.1 1.8 0.0089 16.1 1.8 2.5 2 0 0 2 2 2 1 Zinc ribbon domain FANCL_C PF11793.8 EAK89272.1 - 0.01 16.0 3.9 0.01 16.0 3.9 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 EAK89272.1 - 0.015 15.2 5.9 0.015 15.2 5.9 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 NOB1_Zn_bind PF08772.11 EAK89272.1 - 0.062 13.5 1.5 0.16 12.1 1.5 1.7 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Tyrosinase PF00264.20 EAK89272.1 - 0.3 11.3 7.4 0.16 12.3 4.4 1.9 2 0 0 2 2 2 0 Common central domain of tyrosinase HypA PF01155.19 EAK89272.1 - 0.94 9.5 7.5 0.42 10.7 1.5 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA BIV_Env PF05858.12 EAK89272.1 - 1.2 7.3 3.7 1.7 6.7 3.7 1.1 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) Zn_Tnp_IS1595 PF12760.7 EAK89272.1 - 1.2 9.2 5.9 22 5.1 1.4 3.0 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-C3HC4_3 PF13920.6 EAK89272.1 - 1.9 8.4 16.1 0.094 12.6 5.3 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Tnp_zf-ribbon_2 PF13842.6 EAK89272.1 - 7 7.6 8.0 1.4e+02 3.4 8.6 2.5 1 1 1 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Choline_kinase PF01633.20 EAK89273.1 - 2.2e-51 174.5 2.9 3e-51 174.0 2.9 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EAK89273.1 - 9.3e-07 29.0 0.0 1.1e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family PP2C PF00481.21 EAK89274.1 - 5.1e-63 213.1 0.1 5.5e-52 177.0 0.1 2.7 3 0 0 3 3 3 2 Protein phosphatase 2C RRM_1 PF00076.22 EAK89275.1 - 1.3e-11 44.2 0.0 3.4e-07 30.0 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lsm_interact PF05391.11 EAK89275.1 - 0.0053 16.2 0.3 0.013 15.0 0.3 1.7 1 0 0 1 1 1 1 Lsm interaction motif Sec23_trunk PF04811.15 EAK89276.1 - 9e-64 215.3 0.0 1.3e-63 214.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EAK89276.1 - 5.1e-31 107.3 0.3 2.1e-30 105.3 0.1 2.0 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EAK89276.1 - 1.3e-23 82.8 1.5 2e-23 82.2 0.3 1.9 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EAK89276.1 - 2.1e-13 50.0 0.2 2.8e-12 46.3 0.3 2.6 2 1 0 2 2 2 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 EAK89276.1 - 2.3e-13 49.9 5.2 4.7e-13 48.9 5.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger KSHV_K1 PF11049.8 EAK89276.1 - 0.074 13.0 0.1 0.59 10.1 0.0 2.4 2 0 0 2 2 2 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus VP_N-CPKC PF11475.8 EAK89276.1 - 0.2 11.6 0.6 0.55 10.2 0.6 1.7 1 0 0 1 1 1 0 Virion protein N terminal domain DUF866 PF05907.13 EAK89277.1 - 8.6e-39 132.9 1.8 1e-38 132.7 1.8 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) DEAD PF00270.29 EAK89278.1 - 6.9e-34 117.1 0.0 1.3e-33 116.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89278.1 - 1.8e-23 83.0 0.9 1e-22 80.6 0.2 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EAK89278.1 - 5.7e-18 64.9 0.4 1.4e-17 63.7 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) AAA_22 PF13401.6 EAK89278.1 - 0.056 13.7 0.2 10 6.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EAK89279.1 - 1.4e-15 57.9 0.0 2.4e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EAK89279.1 - 2e-14 53.8 0.0 1e-13 51.5 0.0 2.2 2 1 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EAK89279.1 - 2.8e-12 46.7 0.1 2.3e-10 40.5 0.2 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EAK89279.1 - 1.6e-07 31.8 0.3 7.5e-05 23.2 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 EAK89279.1 - 1.3e-06 28.4 0.0 8e-06 25.9 0.0 2.1 1 1 1 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EAK89279.1 - 1.8e-06 27.8 0.2 8.9e-06 25.5 0.2 2.2 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EAK89279.1 - 1.9e-06 28.0 0.0 5.1e-06 26.5 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 EAK89279.1 - 9e-05 22.8 0.7 0.077 13.3 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 EAK89279.1 - 0.00013 22.0 0.4 0.001 19.1 0.3 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EAK89279.1 - 0.00024 20.6 0.1 0.0044 16.4 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EAK89279.1 - 0.00036 20.4 0.0 0.00058 19.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EAK89279.1 - 0.00039 20.3 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EAK89279.1 - 0.00043 20.6 0.5 0.022 15.1 0.1 2.6 2 1 1 3 3 3 1 AAA domain NTPase_1 PF03266.15 EAK89279.1 - 0.00085 19.3 1.0 0.27 11.1 0.1 2.3 1 1 1 2 2 2 1 NTPase TniB PF05621.11 EAK89279.1 - 0.0011 18.5 0.2 0.052 12.9 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein AAA_30 PF13604.6 EAK89279.1 - 0.0013 18.5 0.0 0.0024 17.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EAK89279.1 - 0.0018 18.1 0.0 0.0046 16.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EAK89279.1 - 0.0018 17.8 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DNA_pol3_delta PF06144.13 EAK89279.1 - 0.0022 17.8 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_18 PF13238.6 EAK89279.1 - 0.005 17.4 0.0 0.0084 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EAK89279.1 - 0.0095 16.3 0.1 0.047 14.1 0.1 2.1 1 1 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 EAK89279.1 - 0.011 15.3 0.0 0.039 13.5 0.0 1.9 2 1 0 2 2 1 0 AAA domain T2SSE PF00437.20 EAK89279.1 - 0.012 14.7 0.1 0.07 12.2 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein Viral_helicase1 PF01443.18 EAK89279.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.18 EAK89279.1 - 0.015 14.6 0.2 0.48 9.7 0.0 2.8 2 1 1 3 3 3 0 FtsK/SpoIIIE family AAA_28 PF13521.6 EAK89279.1 - 0.025 14.8 0.1 0.053 13.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain MCM PF00493.23 EAK89279.1 - 0.025 13.7 0.0 0.041 13.0 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain MeaB PF03308.16 EAK89279.1 - 0.034 13.1 0.1 0.14 11.1 0.1 1.9 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 EAK89279.1 - 0.035 13.8 0.0 0.11 12.2 0.0 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 EAK89279.1 - 0.039 13.1 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_assoc_2 PF16193.5 EAK89279.1 - 0.059 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA C-terminal domain DEAD PF00270.29 EAK89279.1 - 0.068 12.9 0.5 1.9 8.2 0.1 2.4 1 1 0 2 2 2 0 DEAD/DEAH box helicase Sigma54_activ_2 PF14532.6 EAK89279.1 - 0.069 13.3 0.1 0.42 10.7 0.1 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain KTI12 PF08433.10 EAK89279.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 EAK89279.1 - 0.17 12.4 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 EAK89279.1 - 0.17 11.5 0.1 19 4.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain SecA_DEAD PF07517.14 EAK89279.1 - 0.18 11.1 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain DUF1242 PF06842.12 EAK89280.1 - 2.5e-14 52.8 0.5 3.5e-14 52.3 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Phage_holin_3_3 PF16083.5 EAK89280.1 - 0.015 15.4 1.3 0.022 14.9 0.1 1.7 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III Jag_N PF14804.6 EAK89280.1 - 0.069 13.5 0.2 0.098 13.0 0.2 1.2 1 0 0 1 1 1 0 Jag N-terminus Methyltransf_25 PF13649.6 EAK89281.1 - 3.9e-07 30.7 0.0 1.1e-06 29.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK89281.1 - 0.00011 22.1 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain 14-3-3 PF00244.20 EAK89282.1 - 2.8e-98 327.9 5.9 3.3e-98 327.6 5.9 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 EAK89282.1 - 0.0024 18.1 1.2 0.22 11.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EAK89282.1 - 0.03 15.1 2.5 11 7.1 0.1 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat Adaptin_binding PF10199.9 EAK89282.1 - 0.12 13.0 2.9 0.53 10.9 2.2 2.1 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Orbi_VP5 PF00901.17 EAK89282.1 - 0.22 9.9 4.8 3.9 5.8 5.1 2.3 2 1 0 2 2 2 0 Orbivirus outer capsid protein VP5 CREPT PF16566.5 EAK89282.1 - 9.6 6.4 9.1 8.1 6.6 0.1 2.5 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Ribosomal_L11_N PF03946.14 EAK89283.1 - 1.2e-20 73.1 0.2 2.6e-20 72.0 0.2 1.6 1 1 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EAK89283.1 - 4.1e-14 52.8 0.4 6.6e-14 52.2 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain ZYG-11_interact PF05884.12 EAK89283.1 - 0.18 11.2 0.0 0.23 10.8 0.0 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 Prefoldin_2 PF01920.20 EAK89284.1 - 1.2e-17 63.8 9.3 1.6e-17 63.4 9.3 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EAK89284.1 - 0.00012 21.9 5.4 0.00026 20.9 5.4 1.7 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 EAK89284.1 - 0.015 15.3 3.2 0.033 14.3 2.0 1.9 1 1 1 2 2 2 0 Prefoldin subunit COG5 PF10392.9 EAK89284.1 - 0.032 14.4 0.6 0.032 14.4 0.6 2.3 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Spectrin PF00435.21 EAK89284.1 - 0.16 12.4 5.2 5.4 7.5 3.0 2.1 2 0 0 2 2 2 0 Spectrin repeat DUF1664 PF07889.12 EAK89284.1 - 0.18 11.8 0.3 0.18 11.8 0.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Spc24 PF08286.11 EAK89284.1 - 0.73 10.1 7.3 1.6 9.0 0.2 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CALCOCO1 PF07888.11 EAK89284.1 - 3.1 6.5 11.1 28 3.4 11.1 1.9 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FlaC_arch PF05377.11 EAK89284.1 - 6.6 7.2 15.6 5.1 7.6 2.4 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Myb_DNA-binding PF00249.31 EAK89285.1 - 7.1e-45 151.0 16.3 1.9e-10 40.8 0.1 6.8 7 0 0 7 7 7 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EAK89285.1 - 2e-38 130.4 24.4 3.5e-12 46.4 1.9 6.5 2 1 4 6 6 6 5 Myb-like DNA-binding domain SLIDE PF09111.10 EAK89285.1 - 3.3e-06 27.1 7.5 0.062 13.3 0.0 5.2 3 2 3 6 6 6 3 SLIDE Myb_DNA-bind_7 PF15963.5 EAK89285.1 - 0.00018 21.3 1.2 1.7 8.6 0.0 4.5 3 1 1 4 4 4 2 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 EAK89285.1 - 0.011 16.1 10.9 0.078 13.4 0.1 5.6 5 1 0 5 5 5 0 Myb/SANT-like DNA-binding domain Guanylate_cyc PF00211.20 EAK89286.1 - 1.3e-71 240.0 1.7 1.6e-35 122.4 0.1 3.6 3 0 0 3 3 3 3 Adenylate and Guanylate cyclase catalytic domain PhoLip_ATPase_C PF16212.5 EAK89286.1 - 1.6e-23 83.8 33.4 1.6e-23 83.8 33.4 5.0 5 0 0 5 5 5 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EAK89286.1 - 0.00017 21.2 0.7 0.00017 21.2 0.7 3.3 3 1 0 3 3 3 1 E1-E2 ATPase PhoLip_ATPase_N PF16209.5 EAK89286.1 - 0.0082 15.8 1.7 0.047 13.4 1.7 2.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal DOMON PF03351.17 EAK89286.1 - 0.27 11.4 3.1 0.42 10.8 0.3 2.9 2 0 0 2 2 2 0 DOMON domain WD40 PF00400.32 EAK89287.1 - 3.2e-24 84.7 16.1 3.7e-05 24.4 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK89287.1 - 0.017 15.4 0.3 0.23 11.8 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Synaptobrevin PF00957.21 EAK89288.1 - 2.8e-12 46.2 0.2 4e-12 45.8 0.2 1.2 1 0 0 1 1 1 1 Synaptobrevin 2OG-FeII_Oxy_2 PF13532.6 EAK89289.1 - 9e-05 22.7 0.0 9.6e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SH PF01445.17 EAK89289.1 - 3.5 7.7 6.3 1 9.4 3.0 1.8 2 0 0 2 2 2 0 Viral small hydrophobic protein DnaJ PF00226.31 EAK89290.1 - 2.2e-16 59.7 0.5 2.9e-15 56.1 0.5 2.1 1 1 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 EAK89290.1 - 6.9e-09 35.3 0.8 1.2e-08 34.6 0.8 1.4 1 0 0 1 1 1 1 CSL zinc finger FtsJ PF01728.19 EAK89291.1 - 3e-69 232.7 0.0 3.6e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Arf PF00025.21 EAK89292.1 - 9e-78 259.7 0.1 1e-77 259.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EAK89292.1 - 4.7e-14 52.6 0.0 6.5e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EAK89292.1 - 2.2e-13 50.1 0.0 2.7e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EAK89292.1 - 2e-12 47.0 0.0 2.2e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EAK89292.1 - 7.7e-11 41.7 0.4 9.7e-07 28.3 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EAK89292.1 - 5e-10 39.1 0.0 6.2e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EAK89292.1 - 7.9e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EAK89292.1 - 0.01 15.2 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.27 EAK89292.1 - 0.057 12.9 0.1 0.15 11.6 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Ribosomal_L7Ae PF01248.26 EAK89293.1 - 1.1e-21 76.3 0.3 1.8e-21 75.6 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EAK89293.1 - 0.085 12.9 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 RNase P subunit Pop3 NMT PF01233.19 EAK89295.1 - 1.1e-64 217.1 0.1 2.5e-64 216.0 0.1 1.6 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EAK89295.1 - 3e-49 167.4 8.1 7e-39 133.5 6.4 2.9 2 1 1 3 3 3 2 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 EAK89295.1 - 0.00044 20.3 0.0 0.0012 18.9 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EAK89295.1 - 0.0033 17.7 0.0 0.0078 16.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EAK89295.1 - 0.11 12.4 0.0 0.61 10.0 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain RNA_pol_Rpb4 PF03874.16 EAK89296.1 - 3.3e-08 33.9 0.2 1.1e-07 32.2 0.2 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb4 UQ_con PF00179.26 EAK89297.1 - 3.6e-50 169.3 0.0 4e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EAK89297.1 - 0.0012 19.1 0.1 0.0024 18.2 0.0 1.5 2 0 0 2 2 2 1 RWD domain SMK-1 PF04802.15 EAK89298.1 - 1.1e-25 90.6 9.9 3.2e-25 89.1 9.9 1.9 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Ran_BP1 PF00638.18 EAK89298.1 - 0.028 14.7 0.1 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 RanBP1 domain Proteasome PF00227.26 EAK89299.1 - 7.1e-36 123.5 0.0 9e-36 123.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EAK89299.1 - 3.6e-11 42.5 0.0 5.7e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ribosomal_L14e PF01929.17 EAK89300.1 - 5e-25 87.8 1.4 6.7e-25 87.4 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 ABC_tran_CTD PF16326.5 EAK89301.1 - 0.57 10.5 7.3 0.42 10.9 0.5 3.2 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF4407 PF14362.6 EAK89302.1 - 0.00088 18.7 1.7 0.0027 17.1 1.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DEC-1_N PF04625.13 EAK89302.1 - 0.84 8.6 2.5 1.9 7.4 2.5 1.5 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Neisseria_TspB PF05616.13 EAK89302.1 - 5.5 5.4 9.1 11 4.4 9.1 1.4 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein SlyX PF04102.12 EAK89302.1 - 9.3 6.9 10.7 0.36 11.5 0.8 3.7 4 0 0 4 4 4 0 SlyX DUF2203 PF09969.9 EAK89302.1 - 9.6 7.0 9.6 1.9 9.2 3.9 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Myosin_head PF00063.21 EAK89304.1 - 1.2e-172 575.7 9.9 4.1e-172 573.9 9.9 1.9 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_lid_6 PF17866.1 EAK89304.1 - 0.13 12.4 0.1 0.4 10.9 0.1 1.8 1 0 0 1 1 1 0 AAA lid domain Prefoldin PF02996.17 EAK89305.1 - 1.5e-18 66.9 0.9 1.5e-18 66.9 0.9 1.6 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.6 EAK89305.1 - 0.0078 16.2 2.0 0.014 15.4 0.3 2.3 2 1 1 3 3 3 1 Prefoldin subunit PRANC PF09372.10 EAK89305.1 - 0.091 13.1 2.1 0.37 11.1 0.1 2.4 2 0 0 2 2 2 0 PRANC domain DivIVA PF05103.13 EAK89305.1 - 0.26 11.4 18.8 0.29 11.2 4.7 3.0 3 0 0 3 3 3 0 DivIVA protein FliD_N PF02465.18 EAK89305.1 - 0.47 11.2 4.6 13 6.5 0.0 2.7 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus CK2S PF15011.6 EAK89305.1 - 0.68 9.8 6.7 0.64 9.9 0.1 2.6 3 0 0 3 3 3 0 Casein Kinase 2 substrate zf-CpG_bind_C PF12269.8 EAK89305.1 - 2.3 8.0 7.6 0.58 9.9 3.4 2.0 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain Pkinase PF00069.25 EAK89306.1 - 2.3e-62 210.8 0.2 1.2e-61 208.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.29 EAK89306.1 - 9.2e-51 169.9 0.8 4e-17 62.1 0.0 5.0 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 EAK89306.1 - 3.5e-29 101.9 0.0 5.9e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK89306.1 - 1.1e-07 31.5 0.0 2.7e-07 30.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EAK89306.1 - 0.0064 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Tnp_P_element PF12017.8 EAK89306.1 - 0.021 14.3 0.4 0.078 12.4 0.2 2.1 2 0 0 2 2 2 0 Transposase protein Haspin_kinase PF12330.8 EAK89306.1 - 0.033 13.2 1.6 0.1 11.5 0.1 2.4 2 0 0 2 2 2 0 Haspin like kinase domain T3SSipB PF16535.5 EAK89306.1 - 0.65 10.5 2.1 3.3 8.2 1.0 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB zf-CCCH PF00642.24 EAK89308.1 - 9e-06 25.5 18.1 7.5e-05 22.5 1.8 4.2 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EAK89308.1 - 5.3e-05 23.1 14.3 0.00093 19.2 1.5 3.5 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_2 PF14608.6 EAK89308.1 - 0.0005 20.4 19.9 0.086 13.3 4.6 3.8 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EAK89308.1 - 0.23 11.7 9.4 2.7 8.2 1.1 2.8 1 1 1 2 2 2 0 Zinc-finger containing family DEAD PF00270.29 EAK89310.1 - 3.8e-42 144.0 0.1 8.2e-42 142.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89310.1 - 1.5e-21 76.8 0.2 2.8e-20 72.7 0.0 3.2 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89310.1 - 0.036 14.1 0.0 0.036 14.1 0.0 4.3 5 0 0 5 5 5 0 Type III restriction enzyme, res subunit MscL PF01741.18 EAK89310.1 - 0.12 12.7 2.4 0.13 12.5 0.3 2.2 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL AP2 PF00847.20 EAK89311.1 - 3.4e-11 43.2 3.3 6.9e-11 42.2 3.3 1.6 1 0 0 1 1 1 1 AP2 domain DUF2040 PF09745.9 EAK89313.1 - 7.2e-09 35.8 12.4 7.2e-09 35.8 12.4 1.8 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) DNA_pol_E_B PF04042.16 EAK89315.1 - 1e-33 116.5 0.5 2.9e-33 115.0 0.6 1.8 1 1 1 2 2 2 2 DNA polymerase alpha/epsilon subunit B TFIIB PF00382.19 EAK89316.1 - 3.6e-12 46.2 1.3 4.9e-05 23.3 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EAK89316.1 - 4.1e-10 39.0 2.0 4.1e-10 39.0 2.0 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 EAK89316.1 - 0.2 11.4 2.0 11 5.8 0.8 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-RRN7 PF11781.8 EAK89316.1 - 1.4 8.7 8.3 0.53 10.0 3.2 2.6 2 1 1 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 U3_assoc_6 PF08640.11 EAK89317.1 - 1.2e-24 86.2 5.2 1.2e-24 86.2 5.2 2.8 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_19 PF14559.6 EAK89317.1 - 0.12 13.0 0.0 19 5.8 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EAK89317.1 - 0.21 12.5 0.0 65 4.7 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Pep3_Vps18 PF05131.14 EAK89318.1 - 9.5e-10 38.5 1.5 4.1e-08 33.2 0.4 3.3 1 1 1 2 2 2 1 Pep3/Vps18/deep orange family zf-RING_11 PF17123.5 EAK89318.1 - 0.0098 15.6 0.4 0.0098 15.6 0.4 2.6 2 0 0 2 2 2 1 RING-like zinc finger Vps39_2 PF10367.9 EAK89318.1 - 0.08 13.4 0.8 0.54 10.7 0.0 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 EAK89318.1 - 0.47 10.3 3.5 0.25 11.2 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EAK89318.1 - 0.68 10.3 2.1 1.4 9.3 0.8 2.2 1 1 1 2 2 2 0 RING-H2 zinc finger domain TPR_22 PF18833.1 EAK89318.1 - 2.6 8.2 7.1 1.1 9.4 3.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-rbx1 PF12678.7 EAK89319.1 - 7.3e-25 87.0 12.5 7.3e-25 87.0 12.5 1.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EAK89319.1 - 5.2e-18 64.9 9.8 7.4e-18 64.4 9.8 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EAK89319.1 - 8e-07 29.3 14.1 3.3e-05 24.1 14.1 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EAK89319.1 - 1.2e-05 25.0 3.4 1.2e-05 25.0 3.4 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK89319.1 - 0.00082 19.2 11.5 0.0055 16.5 11.5 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EAK89319.1 - 0.0019 17.9 1.2 0.0019 17.9 1.2 2.6 2 0 0 2 2 2 1 RING-like zinc finger FANCL_C PF11793.8 EAK89319.1 - 0.093 12.9 8.9 1.4 9.2 9.4 2.3 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 EAK89319.1 - 0.16 12.0 7.2 0.6 10.2 7.2 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EAK89319.1 - 0.3 11.0 11.7 0.81 9.6 5.5 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK89319.1 - 0.31 11.1 11.0 1.5 8.8 11.0 2.2 1 1 0 1 1 1 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EAK89319.1 - 0.8 9.4 14.3 0.12 12.1 4.4 2.4 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EAK89319.1 - 5.6 7.2 8.3 0.55 10.4 0.5 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF2423 PF10338.9 EAK89320.1 - 4.4e-06 26.8 2.9 9.5e-06 25.7 2.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) VPS13 PF16908.5 EAK89322.1 - 4.7e-13 49.5 0.0 1.6e-11 44.5 0.0 3.1 1 1 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EAK89322.1 - 1.5e-05 25.1 0.2 1.5e-05 25.1 0.2 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 SUB1_ProdP9 PF18213.1 EAK89324.1 - 0.69 9.8 4.7 1.3 8.9 0.4 2.9 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 Rad21_Rec8 PF04824.16 EAK89326.1 - 2.5e-08 33.1 0.0 4.7e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein HGTP_anticodon PF03129.20 EAK89327.1 - 6.9e-22 77.4 0.0 2.3e-21 75.8 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EAK89327.1 - 1.1e-09 38.5 0.0 8.9e-09 35.6 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Actin PF00022.19 EAK89329.1 - 4.7e-30 104.5 0.0 1.1e-27 96.7 0.0 2.2 1 1 0 1 1 1 1 Actin DUF4866 PF16160.5 EAK89329.1 - 0.0065 15.8 0.3 0.011 15.1 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4866) Sec1 PF00995.23 EAK89330.1 - 3e-86 290.9 15.2 3.5e-86 290.7 15.2 1.0 1 0 0 1 1 1 1 Sec1 family RNAse_A_bac PF18431.1 EAK89331.1 - 0.24 12.4 0.3 0.24 12.4 0.3 2.7 3 1 0 3 3 3 0 Bacterial CdiA-CT RNAse A domain CENP-Q PF13094.6 EAK89331.1 - 4.1 7.6 17.6 39 4.4 17.6 2.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Nrap_D4 PF17405.2 EAK89332.1 - 5.5e-26 91.3 0.1 1.1e-25 90.2 0.1 1.6 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 EAK89332.1 - 6.1e-19 68.7 0.3 3.2e-18 66.3 0.1 2.4 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D5 PF17406.2 EAK89332.1 - 6.9e-16 58.4 0.1 1.5e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 EAK89332.1 - 5.1e-14 52.6 1.8 2.1e-06 27.9 0.2 3.1 2 0 0 2 2 2 2 Nrap protein domain 1 Nrap_D2 PF17403.2 EAK89332.1 - 0.0021 17.8 2.9 0.011 15.5 0.6 2.6 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain GTP_EFTU PF00009.27 EAK89333.1 - 3.8e-33 114.7 0.0 5.8e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EAK89333.1 - 5e-05 23.4 0.0 0.0014 18.7 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EAK89333.1 - 0.016 14.8 0.1 0.016 14.8 0.1 2.5 3 0 0 3 3 3 0 Ras family Dynamin_N PF00350.23 EAK89333.1 - 0.36 10.9 4.6 3.5 7.7 0.6 3.1 2 1 0 2 2 2 0 Dynamin family PBP1_TM PF14812.6 EAK89333.1 - 4.1 7.8 5.4 8.1 6.9 5.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CRAL_TRIO PF00650.20 EAK89334.1 - 2.8e-06 27.1 0.3 5.5e-06 26.2 0.3 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain YacG PF03884.14 EAK89334.1 - 0.066 13.0 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG Pox_LP_H2 PF03356.15 EAK89335.1 - 3.5 7.5 6.1 15 5.4 0.6 2.0 2 0 0 2 2 2 0 Viral late protein H2 Aa_trans PF01490.18 EAK89336.1 - 2.4e-26 92.4 43.1 2.8e-26 92.2 43.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SID-1_RNA_chan PF13965.6 EAK89338.1 - 0.65 8.3 3.0 0.71 8.2 3.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 HECT PF00632.25 EAK89339.1 - 3.2e-92 309.3 6.4 3.2e-92 309.3 6.4 3.2 3 2 1 4 4 4 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 EAK89341.1 - 1.2e-48 165.8 0.6 3.9e-48 164.1 0.0 2.2 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK89341.1 - 1.3e-22 80.4 0.0 3.6e-22 78.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK89341.1 - 5.9e-06 25.8 1.7 0.00022 20.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DNA_pol_B_exo1 PF03104.19 EAK89342.1 - 8.6e-68 228.9 10.1 8.6e-68 228.9 10.1 3.3 3 0 0 3 3 3 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.12 EAK89342.1 - 7.8e-22 77.4 11.9 9e-12 44.3 1.9 3.9 3 1 0 3 3 3 3 Domain of unknown function (DUF1744) DNA_pol_B PF00136.21 EAK89342.1 - 3e-11 42.7 0.9 5e-07 28.8 0.0 3.6 3 0 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EAK89342.1 - 4.6e-06 26.5 3.9 0.00012 21.9 0.0 3.0 3 0 0 3 3 3 2 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EAK89342.1 - 1.3e-05 25.2 0.0 8.9e-05 22.5 0.0 2.5 1 0 0 1 1 1 1 RNase_H superfamily V-ATPase_H_C PF11698.8 EAK89342.1 - 1.2 9.3 8.9 0.44 10.7 2.7 3.4 3 0 0 3 3 3 0 V-ATPase subunit H Sec23_trunk PF04811.15 EAK89343.1 - 4.1e-18 65.8 0.3 1.2e-17 64.3 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EAK89343.1 - 5.8e-14 52.6 0.0 5.8e-14 52.6 0.0 2.5 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EAK89343.1 - 1.8e-11 43.9 8.0 5.6e-11 42.3 8.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EAK89343.1 - 1.9e-07 30.8 0.1 1e-06 28.5 0.1 2.2 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EAK89343.1 - 0.0068 16.3 0.0 0.024 14.5 0.0 1.9 1 0 0 1 1 1 1 Gelsolin repeat Clathrin PF00637.20 EAK89344.1 - 3.1e-146 481.0 61.5 2.2e-30 105.4 1.5 10.0 10 0 0 10 10 10 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EAK89344.1 - 9.5e-15 54.3 0.7 1.8e-12 47.0 0.0 4.1 5 0 0 5 5 5 1 Clathrin-H-link TPR_8 PF13181.6 EAK89344.1 - 0.00074 19.5 1.9 2.9 8.3 0.1 4.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EAK89344.1 - 0.0021 18.0 0.1 28 5.0 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EAK89344.1 - 0.0024 17.8 0.3 61 4.1 0.1 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat Clathrin_propel PF01394.20 EAK89344.1 - 0.0096 16.2 0.0 7.9 7.0 0.0 3.3 2 0 0 2 2 2 1 Clathrin propeller repeat Mic1 PF07035.12 EAK89344.1 - 0.044 13.5 10.7 0.024 14.3 4.0 3.6 4 0 0 4 4 4 0 Colon cancer-associated protein Mic1-like DUF4965 PF16335.5 EAK89344.1 - 0.056 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4965) TPR_1 PF00515.28 EAK89344.1 - 0.11 12.4 11.9 6.1 6.8 0.1 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EAK89344.1 - 0.15 12.3 1.8 1.3e+02 2.9 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK89344.1 - 0.54 10.5 7.1 5.8 7.2 0.2 5.0 6 0 0 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 RNA_pol_A_CTD PF03118.15 EAK89345.1 - 0.0017 18.1 9.3 0.12 12.1 2.7 4.2 2 1 2 4 4 4 3 Bacterial RNA polymerase, alpha chain C terminal domain IKKbetaNEMObind PF12179.8 EAK89345.1 - 0.12 12.4 1.4 0.27 11.3 0.5 2.2 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain SMC_N PF02463.19 EAK89346.1 - 2.3e-13 50.1 0.0 7.3e-13 48.5 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EAK89346.1 - 0.00019 21.1 0.1 0.00045 19.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain TMEM95 PF15203.6 EAK89346.1 - 0.7 9.5 13.8 0.96 9.1 0.4 4.2 3 1 0 3 3 3 0 TMEM95 family AAA_18 PF13238.6 EAK89346.1 - 0.9 10.1 0.0 0.9 10.1 0.0 4.6 5 0 0 5 5 5 0 AAA domain Peptidase_C2 PF00648.21 EAK89347.1 - 2.1e-33 115.6 0.3 2.2e-31 109.0 0.3 2.2 1 1 0 1 1 1 1 Calpain family cysteine protease TP6A_N PF04406.14 EAK89350.1 - 1.3e-17 63.5 0.6 5.1e-17 61.6 0.2 2.1 2 0 0 2 2 2 1 Type IIB DNA topoisomerase TPT PF03151.16 EAK89352.1 - 4.7e-25 88.5 34.3 5.7e-25 88.3 34.3 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EAK89352.1 - 2e-08 34.5 41.2 5.7e-08 33.0 19.9 2.9 2 1 1 3 3 3 2 EamA-like transporter family UAA PF08449.11 EAK89352.1 - 0.00027 20.2 37.3 0.00041 19.6 37.3 1.3 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 EAK89352.1 - 0.055 12.7 33.1 2.6 7.2 32.8 2.8 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport FHIPEP PF00771.20 EAK89353.1 - 8.1 4.8 20.1 20 3.5 20.1 1.5 1 0 0 1 1 1 0 FHIPEP family Acyltransferase PF01553.21 EAK89355.1 - 8.6e-11 41.6 0.0 2.5e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Acyltransferase DDOST_48kD PF03345.14 EAK89355.1 - 0.0037 16.2 0.6 0.0057 15.5 0.6 1.3 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Glyco_hydro_31 PF01055.26 EAK89356.1 - 4e-87 293.2 13.1 4e-87 293.2 13.1 2.9 3 1 0 3 3 3 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EAK89356.1 - 5.8e-12 45.8 0.2 5.8e-12 45.8 0.2 3.3 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 EAK89356.1 - 0.046 14.0 1.2 0.21 11.9 1.2 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) PP2C_2 PF13672.6 EAK89357.1 - 1.1e-05 25.1 0.0 1.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EAK89357.1 - 3.2e-05 23.9 0.0 0.17 11.8 0.0 3.1 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EAK89357.1 - 0.0059 16.3 2.5 0.13 11.8 0.0 2.7 3 0 0 3 3 3 2 Protein phosphatase 2C Sin_N PF04801.13 EAK89358.1 - 2.1e-43 149.2 5.3 1.1e-26 94.1 0.1 3.1 3 0 0 3 3 3 3 Sin-like protein conserved region RNA_GG_bind PF10258.9 EAK89359.1 - 2.2e-24 85.3 0.0 3.6e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 PHAX RNA-binding domain Paz_1 PF18349.1 EAK89359.1 - 0.052 13.5 0.5 0.1 12.5 0.2 1.7 1 1 0 1 1 1 0 PAZ domain CTD_bind PF04818.13 EAK89360.1 - 0.014 16.2 0.3 0.055 14.3 0.3 2.1 1 0 0 1 1 1 0 RNA polymerase II-binding domain. PRD PF00874.20 EAK89360.1 - 0.21 11.9 3.3 0.42 11.0 1.3 2.5 2 0 0 2 2 2 0 PRD domain Cnd1 PF12717.7 EAK89360.1 - 0.48 10.4 3.0 0.34 11.0 0.8 1.9 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Y_phosphatase3 PF13350.6 EAK89361.1 - 1.3e-30 107.2 0.0 9.1e-28 97.8 0.0 2.2 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EAK89361.1 - 0.00074 19.1 0.8 0.0061 16.2 0.0 2.7 2 1 1 3 3 3 1 Tyrosine phosphatase family FH2 PF02181.23 EAK89362.1 - 1.4e-40 139.6 8.9 1.4e-40 139.6 8.9 3.3 2 1 1 3 3 3 2 Formin Homology 2 Domain UCH PF00443.29 EAK89365.1 - 1.1e-50 172.6 0.0 2.9e-49 167.9 0.0 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK89365.1 - 4.3e-17 62.7 0.5 5.3e-12 46.0 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EAK89365.1 - 0.0032 17.2 0.1 0.014 15.1 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin-specific protease C-terminal Drc1-Sld2 PF11719.8 EAK89366.1 - 0.00035 20.2 2.5 0.00035 20.2 2.5 2.1 2 1 1 3 3 3 1 DNA replication and checkpoint protein EHD_N PF16880.5 EAK89366.1 - 0.6 10.1 5.9 3.2 7.7 3.7 2.7 2 0 0 2 2 2 0 N-terminal EH-domain containing protein Myc-LZ PF02344.15 EAK89366.1 - 0.69 10.1 7.6 0.22 11.7 0.5 3.0 3 0 0 3 3 3 0 Myc leucine zipper domain TolA_bind_tri PF16331.5 EAK89366.1 - 0.69 10.0 5.6 1.1 9.3 0.1 3.2 3 0 0 3 3 3 0 TolA binding protein trimerisation Pro_isomerase PF00160.21 EAK89367.1 - 2.8e-43 147.9 0.1 3.4e-43 147.7 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-CCCH_4 PF18044.1 EAK89368.1 - 5.7e-06 26.0 5.9 9.6e-06 25.3 5.9 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EAK89368.1 - 5.7e-05 23.0 5.1 0.0001 22.2 5.1 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EAK89368.1 - 0.00014 21.7 4.5 0.00026 20.8 4.5 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2971 PF11185.8 EAK89368.1 - 1.3 10.2 4.8 4.2 8.6 4.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2971) Ribo_biogen_C PF04034.13 EAK89369.1 - 1.5e-40 137.8 0.0 2.8e-40 137.0 0.0 1.5 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EAK89369.1 - 1.2e-05 25.0 0.5 2.1e-05 24.2 0.5 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Presenilin PF01080.17 EAK89369.1 - 0.00061 18.7 20.8 0.00096 18.0 20.8 1.2 1 0 0 1 1 1 1 Presenilin SDA1 PF05285.12 EAK89369.1 - 0.0011 18.5 38.7 0.0011 18.5 38.7 1.7 2 0 0 2 2 2 1 SDA1 Spore_coat_CotO PF14153.6 EAK89369.1 - 0.013 15.4 20.6 0.023 14.6 20.6 1.4 1 0 0 1 1 1 0 Spore coat protein CotO CCSAP PF15748.5 EAK89369.1 - 0.028 14.6 14.7 0.042 14.0 14.7 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Nop14 PF04147.12 EAK89369.1 - 0.12 10.6 49.5 0.23 9.7 49.5 1.4 1 0 0 1 1 1 0 Nop14-like family Raftlin PF15250.6 EAK89369.1 - 0.64 8.7 11.3 0.86 8.3 11.3 1.2 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 EAK89369.1 - 1.2 7.2 13.5 1.6 6.8 13.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BSMAP PF12280.8 EAK89369.1 - 1.3 9.2 3.7 3 8.0 3.7 1.6 1 0 0 1 1 1 0 Brain specific membrane anchored protein DUF2151 PF10221.9 EAK89369.1 - 3.5 6.1 14.1 4.8 5.6 14.1 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator MFS_1 PF07690.16 EAK89371.1 - 2.4e-35 122.1 36.0 1.2e-26 93.5 3.1 2.9 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF3883 PF13020.6 EAK89372.1 - 7e-11 42.0 0.1 3.1e-10 40.0 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3883) HATPase_c_3 PF13589.6 EAK89372.1 - 8.5e-05 22.4 0.0 0.00022 21.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SAC3 PF12209.8 EAK89372.1 - 0.12 12.5 0.8 1.1 9.5 0.2 2.8 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain DNA_pol_D_N PF18018.1 EAK89373.1 - 2e-33 115.2 0.0 3e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 EAK89373.1 - 1.4e-27 96.4 0.3 2.1e-27 95.9 0.3 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B PRA1 PF03208.19 EAK89374.1 - 5.2e-24 84.5 2.9 7e-24 84.1 2.9 1.1 1 0 0 1 1 1 1 PRA1 family protein DHHC PF01529.20 EAK89374.1 - 0.76 9.9 4.4 1.4 9.0 4.4 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase KH_1 PF00013.29 EAK89375.1 - 0.016 15.0 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 KH domain DUF4411 PF14367.6 EAK89376.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) YbfN PF13982.6 EAK89377.1 - 0.0045 17.2 0.2 0.013 15.8 0.0 1.8 2 0 0 2 2 2 1 YbfN-like lipoprotein Laminin_I PF06008.14 EAK89377.1 - 0.0059 16.3 5.9 0.0069 16.1 5.9 1.0 1 0 0 1 1 1 1 Laminin Domain I Spc7 PF08317.11 EAK89377.1 - 0.015 14.2 9.2 0.016 14.1 9.2 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein RmuC PF02646.16 EAK89377.1 - 0.044 12.9 4.5 2.3 7.3 3.2 2.0 1 1 0 2 2 2 0 RmuC family GAS PF13851.6 EAK89377.1 - 0.046 13.1 11.9 0.14 11.5 11.7 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.5 EAK89377.1 - 0.049 14.2 7.0 0.062 13.9 6.0 1.7 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MSC PF09402.10 EAK89377.1 - 0.057 12.9 2.2 0.057 12.9 2.2 1.0 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain CENP-K PF11802.8 EAK89377.1 - 0.076 12.6 8.2 0.09 12.3 8.2 1.0 1 0 0 1 1 1 0 Centromere-associated protein K TMPIT PF07851.13 EAK89377.1 - 0.11 11.8 5.2 0.12 11.6 5.2 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF724 PF05266.14 EAK89377.1 - 0.12 12.1 6.2 0.15 11.9 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3782 PF12644.7 EAK89377.1 - 0.13 12.5 4.0 0.21 11.8 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) DUF1664 PF07889.12 EAK89377.1 - 0.22 11.6 4.3 0.39 10.7 3.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CorA PF01544.18 EAK89377.1 - 0.28 10.4 4.2 0.34 10.2 4.2 1.2 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein PI3K_P85_iSH2 PF16454.5 EAK89377.1 - 0.33 10.5 10.5 0.27 10.8 4.3 2.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Arc_PepC_II PF06847.11 EAK89377.1 - 0.39 11.3 1.7 2 9.0 1.7 2.0 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II APG6_N PF17675.1 EAK89377.1 - 0.41 11.2 11.4 0.64 10.5 11.4 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region Rho_Binding PF08912.11 EAK89377.1 - 0.54 11.1 10.3 0.64 10.9 2.9 2.2 1 1 1 2 2 2 0 Rho Binding FapA PF03961.13 EAK89377.1 - 0.72 8.4 7.1 0.81 8.2 7.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A KxDL PF10241.9 EAK89377.1 - 1 9.7 6.5 0.8 10.0 4.0 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein CCDC-167 PF15188.6 EAK89377.1 - 3.5 8.0 10.9 1.8 8.9 8.0 1.8 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 MRPL52 PF18699.1 EAK89377.1 - 5.2 7.3 8.7 1.2 9.4 4.4 1.9 1 1 1 2 2 2 0 Mitoribosomal protein mL52 ubiquitin PF00240.23 EAK89382.1 - 3.2e-11 42.8 0.0 0.22 11.3 0.0 8.5 9 1 0 9 9 9 3 Ubiquitin family Rad60-SLD PF11976.8 EAK89382.1 - 2e-09 37.2 1.1 1.3 8.9 0.0 7.3 8 1 0 8 8 8 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EAK89382.1 - 2.2e-05 24.8 0.0 0.06 13.8 0.0 4.4 4 0 0 4 4 4 1 Ubiquitin-like domain DUF778 PF05608.12 EAK89384.1 - 0.087 13.2 3.2 0.78 10.1 3.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF778) DUF3972 PF13118.6 EAK89385.1 - 0.043 14.2 1.4 0.043 14.2 1.4 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3972) Histone_HNS PF00816.21 EAK89385.1 - 1.1 10.1 9.0 4.6 8.1 0.8 2.5 2 0 0 2 2 2 0 H-NS histone family Fez1 PF06818.15 EAK89385.1 - 1.7 9.0 22.3 0.5 10.8 19.0 1.7 2 0 0 2 2 2 0 Fez1 Prominin PF05478.11 EAK89385.1 - 4.3 5.2 10.7 5.9 4.7 10.3 1.5 1 1 0 1 1 1 0 Prominin APG6_N PF17675.1 EAK89385.1 - 7 7.2 15.2 0.72 10.4 5.9 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region SURF6 PF04935.12 EAK89386.1 - 1.6e-12 47.7 39.9 1.6e-12 47.7 39.9 1.6 1 1 0 1 1 1 1 Surfeit locus protein 6 E2F_TDP PF02319.20 EAK89387.1 - 5.6e-13 48.7 0.0 1.1e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain ANAPC4_WD40 PF12894.7 EAK89388.1 - 1.2e-10 41.5 0.1 7.2e-05 23.0 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EAK89388.1 - 3.3e-09 36.4 0.2 6e-09 35.5 0.2 1.5 1 0 0 1 1 1 1 LisH RAB3GAP2_N PF14655.6 EAK89388.1 - 1.8e-05 24.2 1.0 0.00018 20.9 0.1 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus WD40 PF00400.32 EAK89388.1 - 0.0044 17.8 0.3 0.43 11.5 0.2 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 EAK89389.1 - 1.2e-08 34.6 11.0 2.2e-08 33.8 11.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAK89389.1 - 3.2e-06 26.9 11.2 5e-06 26.3 11.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK89389.1 - 1.5e-05 24.8 11.2 2.8e-05 23.9 11.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK89389.1 - 8.6e-05 22.8 12.2 0.00015 22.1 12.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EAK89389.1 - 0.00029 20.8 11.3 0.00054 19.9 11.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EAK89389.1 - 0.013 15.5 8.7 0.027 14.5 8.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_6 PF14835.6 EAK89389.1 - 0.078 12.9 6.9 0.14 12.0 6.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 EAK89389.1 - 0.45 10.4 6.4 0.9 9.5 6.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EAK89389.1 - 0.54 10.2 10.1 0.99 9.3 10.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EAK89389.1 - 0.99 9.3 4.9 2.5 8.0 4.9 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EAK89389.1 - 1 9.7 6.5 2.6 8.4 6.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain VPS9 PF02204.18 EAK89390.1 - 3.1e-21 75.5 0.3 7.8e-21 74.2 0.3 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EAK89390.1 - 0.038 14.3 0.0 0.17 12.2 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) ELMO_CED12 PF04727.13 EAK89391.1 - 3.8e-39 134.6 1.7 8.2e-39 133.5 1.7 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family DUF4509 PF14970.6 EAK89391.1 - 0.049 13.6 0.2 0.089 12.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) TERF2_RBM PF16772.5 EAK89392.1 - 0.017 14.5 0.0 0.045 13.2 0.0 1.7 1 0 0 1 1 1 0 Telomeric repeat-binding factor 2 Rap1-binding motif PMI_typeI PF01238.21 EAK89393.1 - 1.9e-74 251.1 1.6 2e-73 247.7 1.4 2.4 2 1 0 2 2 2 1 Phosphomannose isomerase type I CWC25 PF12542.8 EAK89393.1 - 0.019 15.8 1.9 1.3 9.9 0.1 2.6 2 0 0 2 2 2 0 Pre-mRNA splicing factor DUF4522 PF15022.6 EAK89393.1 - 2.1 8.6 4.8 0.79 10.0 1.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4522) DUF1043 PF06295.12 EAK89393.1 - 7.5 6.6 10.7 0.18 11.8 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) ENTH PF01417.20 EAK89394.1 - 2.7e-35 121.2 0.2 4.4e-35 120.5 0.2 1.4 1 0 0 1 1 1 1 ENTH domain HEAT PF02985.22 EAK89395.1 - 2.4e-17 61.5 4.4 0.0015 18.6 0.1 10.0 10 0 0 10 10 10 4 HEAT repeat HEAT_EZ PF13513.6 EAK89395.1 - 6.5e-10 39.3 0.1 0.032 14.7 0.0 6.6 8 0 0 8 8 8 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EAK89395.1 - 6.4e-09 36.3 10.5 0.024 15.2 0.0 9.2 10 1 1 11 11 11 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 EAK89395.1 - 1.9e-07 31.4 0.1 0.1 13.0 0.0 6.2 6 0 0 6 6 6 2 HEAT repeats Cohesin_HEAT PF12765.7 EAK89395.1 - 0.00092 19.5 1.3 4 7.8 0.0 4.5 4 0 0 4 4 4 2 HEAT repeat associated with sister chromatid cohesion ERCC3_RAD25_C PF16203.5 EAK89396.1 - 3.8e-108 360.4 0.1 7e-108 359.5 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EAK89396.1 - 8.3e-28 97.1 0.0 1.4e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89396.1 - 2.6e-13 50.3 0.0 2.6e-13 50.3 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EAK89396.1 - 1.4e-09 38.3 0.5 8e-09 35.8 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EAK89396.1 - 0.00043 19.1 0.0 0.00075 18.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_14 PF13173.6 EAK89396.1 - 0.009 16.0 1.0 4 7.5 1.7 2.6 2 0 0 2 2 2 2 AAA domain Cwf_Cwc_15 PF04889.12 EAK89397.1 - 1.6e-23 83.8 32.3 6.8e-22 78.4 32.3 2.1 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF413 PF04219.12 EAK89397.1 - 1 9.5 4.5 0.66 10.0 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF GNAT_acetyltr_2 PF13718.6 EAK89399.1 - 1.9e-76 256.5 0.0 9.7e-76 254.1 0.0 2.2 1 1 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EAK89399.1 - 4.1e-56 189.6 0.0 8.5e-56 188.6 0.0 1.6 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 EAK89399.1 - 4.2e-40 137.9 3.6 1.2e-39 136.5 3.6 1.7 1 1 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 EAK89399.1 - 2.7e-26 91.3 0.0 6.7e-26 90.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_1 PF00583.25 EAK89399.1 - 0.033 14.4 0.0 0.085 13.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Pfk_N PF18468.1 EAK89399.1 - 0.033 14.6 0.5 0.49 10.8 0.0 2.9 3 0 0 3 3 3 0 Phosphofructokinase N-terminal domain yeast Acetyltransf_7 PF13508.7 EAK89399.1 - 0.11 12.9 0.0 0.56 10.7 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EAK89399.1 - 0.13 12.2 0.0 0.49 10.4 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein Dynamin_N PF00350.23 EAK89400.1 - 9.2e-13 48.6 1.6 2.8e-12 47.0 0.0 2.8 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EAK89400.1 - 0.0017 18.4 0.0 0.011 15.8 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2639 PF11121.8 EAK89400.1 - 0.067 13.2 0.1 0.18 11.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) Acetyltransf_1 PF00583.25 EAK89401.1 - 1.3e-06 28.7 0.0 2.1e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EAK89401.1 - 7.2e-05 23.1 0.1 0.00018 21.8 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EAK89401.1 - 0.00084 19.3 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EAK89401.1 - 0.0041 17.1 0.1 0.019 14.9 0.0 2.1 3 1 1 4 4 4 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EAK89401.1 - 0.0051 16.3 0.8 0.0051 16.3 0.8 1.4 2 0 0 2 2 2 1 Putative acetyl-transferase DUF1839 PF08893.10 EAK89401.1 - 0.18 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) TBP PF00352.21 EAK89402.1 - 1.2e-53 179.0 0.0 1.4e-25 89.1 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EAK89402.1 - 0.019 15.1 0.0 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) S1 PF00575.23 EAK89403.1 - 1.2e-23 83.2 19.1 2.3e-06 27.9 0.0 9.5 10 0 0 10 10 10 5 S1 RNA binding domain Suf PF05843.14 EAK89403.1 - 1.2e-07 32.0 16.8 0.0025 17.9 0.1 4.7 4 1 1 5 5 5 3 Suppressor of forked protein (Suf) TPR_5 PF12688.7 EAK89403.1 - 0.0022 18.2 0.0 0.0048 17.1 0.0 1.5 1 0 0 1 1 1 1 Tetratrico peptide repeat ProQ_C PF17516.2 EAK89403.1 - 0.05 13.0 0.1 1.6 8.2 0.0 3.0 2 0 0 2 2 2 0 ProQ C-terminal domain RICTOR_M PF14666.6 EAK89403.1 - 0.057 13.2 0.3 3.6 7.4 0.0 3.4 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain TPR_14 PF13428.6 EAK89403.1 - 0.1 13.5 0.0 8.1 7.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SHS2_FTSA PF02491.20 EAK89405.1 - 0.038 14.4 2.0 2.4 8.6 1.5 2.7 3 0 0 3 3 3 0 SHS2 domain inserted in FTSA E1-E2_ATPase PF00122.20 EAK89407.1 - 5.3e-26 91.2 0.1 5.3e-26 91.2 0.1 2.6 2 0 0 2 2 2 1 E1-E2 ATPase P5-ATPase PF12409.8 EAK89407.1 - 3.8e-12 46.4 0.1 1.7e-11 44.3 0.1 2.2 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 EAK89407.1 - 4.3e-10 40.2 0.0 0.023 15.0 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EAK89407.1 - 0.0001 22.3 0.2 0.0003 20.8 0.2 1.7 1 1 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EAK89407.1 - 0.46 10.2 9.9 0.58 9.8 0.5 3.1 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF3060 PF11259.8 EAK89407.1 - 1.1 9.1 5.2 0.66 9.7 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) NUP50 PF08911.11 EAK89408.1 - 3.1e-05 24.6 0.0 3.1e-05 24.6 0.0 4.2 3 1 1 4 4 4 1 NUP50 (Nucleoporin 50 kDa) CPSF100_C PF13299.6 EAK89408.1 - 0.34 11.1 15.7 7.2 6.8 0.1 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SDA1 PF05285.12 EAK89408.1 - 0.64 9.4 29.7 0.13 11.7 21.4 2.2 2 0 0 2 2 2 0 SDA1 RR_TM4-6 PF06459.12 EAK89408.1 - 0.78 9.5 24.6 0.044 13.6 16.2 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 EAK89408.1 - 0.83 7.7 6.4 1 7.4 6.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.12 EAK89408.1 - 2.7 6.1 34.3 0.055 11.7 24.7 2.0 2 0 0 2 2 2 0 Nop14-like family DUF2052 PF09747.9 EAK89408.1 - 3.7 7.6 25.7 3.2 7.8 18.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) AIF_C PF14721.6 EAK89408.1 - 6.5 7.1 10.6 6.8 7.1 7.8 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FancD2 PF14631.6 EAK89408.1 - 8.4 3.6 10.6 13 3.0 10.6 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease MIR PF02815.19 EAK89409.1 - 4e-07 30.1 0.3 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 MIR domain Ins145_P3_rec PF08709.11 EAK89409.1 - 0.00016 21.0 1.1 0.05 12.8 0.0 2.5 1 1 1 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF4564 PF15169.6 EAK89409.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4564) PCNA_N PF00705.18 EAK89412.1 - 4e-45 152.6 1.1 6.5e-45 151.9 1.1 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EAK89412.1 - 4.3e-40 136.8 0.0 1.5e-39 135.1 0.0 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EAK89412.1 - 4e-10 39.2 0.6 3.3e-06 26.4 0.4 2.0 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EAK89412.1 - 0.00015 21.3 0.4 0.00017 21.1 0.4 1.2 1 0 0 1 1 1 1 Rad9 DNA_pol3_beta PF00712.19 EAK89412.1 - 0.0036 17.4 0.5 5.1 7.3 0.0 3.1 1 1 1 3 3 3 2 DNA polymerase III beta subunit, N-terminal domain PARG_cat PF05028.14 EAK89413.1 - 7.7e-51 173.4 0.1 1e-50 172.9 0.1 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Histone_H2A_C PF16211.5 EAK89414.1 - 3.1e-18 65.2 0.7 6.1e-18 64.3 0.7 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EAK89414.1 - 9.1e-18 64.9 0.0 1.3e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EAK89414.1 - 9.7e-05 22.6 0.1 0.00017 21.8 0.0 1.4 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YdfA_immunity PF12127.8 EAK89414.1 - 0.095 11.8 0.1 0.11 11.5 0.1 1.0 1 0 0 1 1 1 0 SigmaW regulon antibacterial Pkinase PF00069.25 EAK89415.1 - 1e-55 189.0 3.7 1e-55 189.0 3.7 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK89415.1 - 2.3e-37 128.7 0.6 6.1e-37 127.3 0.6 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK89415.1 - 0.00023 20.6 0.0 0.00043 19.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like TFIIE_beta PF02186.15 EAK89415.1 - 0.49 10.7 5.0 30 5.0 0.2 4.1 4 0 0 4 4 4 0 TFIIE beta subunit core domain Ribosomal_L6e_N PF03868.15 EAK89416.1 - 0.047 13.9 3.3 0.072 13.3 3.3 1.3 1 0 0 1 1 1 0 Ribosomal protein L6, N-terminal domain DUF5082 PF16888.5 EAK89416.1 - 0.057 13.7 11.6 0.12 12.7 5.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) THP2 PF09432.10 EAK89416.1 - 0.09 12.8 6.0 0.12 12.4 5.4 1.5 1 1 0 1 1 1 0 Tho complex subunit THP2 Actin PF00022.19 EAK89417.1 - 1.6e-126 422.3 0.0 1.8e-126 422.1 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EAK89417.1 - 1.3e-06 27.5 0.2 0.0015 17.4 0.0 2.4 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 EAK89417.1 - 0.0031 17.9 0.1 3.7 8.0 0.0 3.0 3 0 0 3 3 3 2 Cell division protein FtsA HAP2-GCS1 PF10699.9 EAK89418.1 - 1.7e-16 59.9 0.0 3.4e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Male gamete fusion factor His_Phos_1 PF00300.22 EAK89419.1 - 1.1e-08 35.0 0.0 1.3e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CsgA PF17334.2 EAK89420.1 - 0.025 15.3 0.2 0.029 15.1 0.2 1.2 1 0 0 1 1 1 0 Minor curli fiber component A XRN_N PF03159.18 EAK89421.1 - 8.6e-97 323.3 0.0 8.6e-97 323.3 0.0 2.9 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EAK89421.1 - 1.4e-76 258.3 18.9 7.4e-53 180.1 4.2 3.2 1 1 1 2 2 2 2 Xrn1 helical domain ZapB PF06005.12 EAK89423.1 - 0.0023 18.3 4.6 0.0023 18.3 4.6 8.6 3 3 2 6 6 6 3 Cell division protein ZapB Par3_HAL_N_term PF12053.8 EAK89423.1 - 1.2 9.4 5.1 0.45 10.7 0.1 2.9 3 0 0 3 3 3 0 N-terminal of Par3 and HAL proteins zf-AN1 PF01428.16 EAK89424.1 - 1.5e-12 47.5 23.3 7.3e-07 29.3 8.9 2.3 2 0 0 2 2 2 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EAK89424.1 - 1.6e-05 25.1 21.9 5.9e-05 23.3 5.8 2.3 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain zf-C5HC2 PF02928.16 EAK89424.1 - 0.00023 21.5 11.0 0.0022 18.3 1.6 2.6 2 0 0 2 2 2 2 C5HC2 zinc finger C1_4 PF07975.12 EAK89424.1 - 2.3 8.5 14.2 3.9 7.8 2.9 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain SNF2_N PF00176.23 EAK89425.1 - 4e-60 203.4 0.0 4e-60 203.4 0.0 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK89425.1 - 3.5e-19 69.2 0.2 2.6e-18 66.4 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89425.1 - 1.4e-16 60.9 0.3 5.1e-15 55.9 0.0 3.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Bromodomain PF00439.25 EAK89425.1 - 1.7e-15 56.8 0.4 4.2e-15 55.6 0.4 1.7 1 0 0 1 1 1 1 Bromodomain DEAD PF00270.29 EAK89425.1 - 8.1e-07 29.0 0.0 2.3e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HSA PF07529.13 EAK89425.1 - 0.00034 20.9 10.2 0.00034 20.9 10.2 3.0 4 0 0 4 4 4 1 HSA RNA_pol_3_Rpc31 PF11705.8 EAK89425.1 - 0.002 18.4 10.6 0.002 18.4 10.6 4.1 4 0 0 4 4 4 1 DNA-directed RNA polymerase III subunit Rpc31 TetR_C_6 PF13977.6 EAK89425.1 - 0.16 12.2 0.4 0.32 11.2 0.4 1.5 1 0 0 1 1 1 0 BetI-type transcriptional repressor, C-terminal Rhabdo_ncap PF00945.18 EAK89425.1 - 1.9 7.3 9.3 0.023 13.6 1.4 1.8 2 0 0 2 2 2 0 Rhabdovirus nucleocapsid protein DUF3341 PF11821.8 EAK89426.1 - 0.047 13.3 8.4 0.24 11.1 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3341) DUF3149 PF11346.8 EAK89426.1 - 0.073 12.7 0.6 0.073 12.7 0.6 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3149) PNTB PF02233.16 EAK89427.1 - 4.7e-173 576.3 17.3 4.7e-173 576.3 17.3 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EAK89427.1 - 3.1e-67 226.0 3.0 6.5e-67 225.0 3.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EAK89427.1 - 1.2e-43 148.7 0.0 2.4e-43 147.7 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EAK89427.1 - 3.4e-30 104.3 5.9 3.4e-30 104.3 5.9 4.7 3 1 1 5 5 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EAK89427.1 - 2.7e-07 30.1 0.6 0.013 14.8 0.1 3.6 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EAK89427.1 - 0.0015 17.8 0.3 0.0029 16.9 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EAK89427.1 - 0.0042 17.1 0.1 0.015 15.3 0.1 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TPP_enzyme_M PF00205.22 EAK89427.1 - 0.023 14.4 0.2 0.75 9.5 0.1 3.1 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain NAD_binding_2 PF03446.15 EAK89427.1 - 0.048 13.8 1.9 0.14 12.3 0.3 2.7 3 1 0 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase GIDA PF01134.22 EAK89427.1 - 0.11 11.6 0.5 0.18 10.8 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DUF3446 PF11928.8 EAK89427.1 - 1.9 8.9 11.4 0.83 10.0 7.6 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 EAK89427.1 - 4.4 6.9 10.0 7.5 6.1 10.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 EAK89429.1 - 1.6e-44 152.3 1.5 3.8e-27 94.9 0.1 2.1 1 1 1 2 2 2 2 CDC45-like protein DEPP PF15343.6 EAK89429.1 - 0.035 14.2 0.7 0.18 11.9 0.2 2.2 2 1 0 2 2 2 0 Decidual protein induced by progesterone family DAGK_acc PF00609.19 EAK89430.1 - 3.4e-16 60.0 0.1 2.7e-11 44.0 0.0 3.5 3 0 0 3 3 3 2 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EAK89430.1 - 3.3e-11 42.9 0.0 9.5e-11 41.4 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ephrin_rec_like PF07699.13 EAK89430.1 - 0.13 12.1 5.1 0.28 11.0 1.5 2.5 2 0 0 2 2 2 0 Putative ephrin-receptor like V-ATPase_G PF03179.15 EAK89431.1 - 5.6e-06 26.8 12.5 5.6e-06 26.8 12.5 2.4 2 0 0 2 2 2 1 Vacuolar (H+)-ATPase G subunit KdpD PF02702.17 EAK89431.1 - 0.0078 15.7 1.7 0.012 15.1 1.7 1.3 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain DUF4449 PF14613.6 EAK89431.1 - 0.013 15.7 3.1 0.013 15.7 3.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4449) ATP-synt_B PF00430.18 EAK89431.1 - 5.2 7.2 12.8 0.87 9.7 7.1 2.3 2 1 1 3 3 3 0 ATP synthase B/B' CF(0) T3SSipB PF16535.5 EAK89431.1 - 7.1 7.1 13.2 0.13 12.7 4.6 2.0 1 1 0 2 2 2 0 Type III cell invasion protein SipB TFIIF_beta PF02270.15 EAK89432.1 - 2.2e-06 27.7 0.0 8.1e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain RPA_C PF08784.11 EAK89432.1 - 0.0011 19.6 0.2 0.0019 18.9 0.2 1.3 1 0 0 1 1 1 1 Replication protein A C terminal PPP1R32 PF15691.5 EAK89432.1 - 0.012 14.7 0.3 0.016 14.4 0.3 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 32 CAF1-p150_C2 PF15539.6 EAK89432.1 - 0.078 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term Pkinase_Tyr PF07714.17 EAK89433.1 - 1.3e-62 211.5 0.0 1.8e-62 211.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EAK89433.1 - 3e-55 187.4 0.0 5e-55 186.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 EAK89433.1 - 7.2e-10 39.2 0.0 2.4e-09 37.5 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EAK89433.1 - 3e-08 33.6 0.1 1.3e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) MORN PF02493.20 EAK89433.1 - 0.00037 20.2 13.0 0.51 10.3 0.1 4.2 4 0 0 4 4 4 3 MORN repeat Pkinase_fungal PF17667.1 EAK89433.1 - 0.00039 19.3 0.0 0.00092 18.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EAK89433.1 - 0.0092 15.3 0.0 0.025 13.9 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EAK89433.1 - 0.039 13.3 0.0 1.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EAK89434.1 - 1.5e-08 34.4 0.1 3e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EAK89434.1 - 0.017 15.3 0.0 60 4.3 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat Cnd1 PF12717.7 EAK89434.1 - 0.026 14.6 0.1 0.026 14.6 0.1 4.3 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Pkinase_fungal PF17667.1 EAK89434.1 - 0.11 11.2 2.7 0.29 9.9 0.0 2.3 2 0 0 2 2 2 0 Fungal protein kinase DUF4407 PF14362.6 EAK89434.1 - 0.31 10.4 1.9 0.47 9.8 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FH2 PF02181.23 EAK89435.1 - 5.3e-42 144.3 11.9 1.2e-26 93.7 5.8 2.8 3 0 0 3 3 3 2 Formin Homology 2 Domain SAP PF02037.27 EAK89436.1 - 6.6e-07 28.9 1.5 8.9e-07 28.5 0.3 1.9 2 0 0 2 2 2 1 SAP domain OST-HTH PF12872.7 EAK89436.1 - 0.00054 19.7 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Stn1 PF10451.9 EAK89436.1 - 0.031 13.3 7.7 0.019 13.9 4.6 2.1 2 0 0 2 2 2 0 Telomere regulation protein Stn1 LETM1 PF07766.13 EAK89436.1 - 0.1 11.9 0.1 0.1 11.9 0.1 3.3 3 0 0 3 3 3 0 LETM1-like protein DUF3099 PF11298.8 EAK89437.1 - 0.046 13.8 0.1 0.046 13.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) DSHCT PF08148.12 EAK89441.1 - 8.8e-46 155.6 0.0 2e-45 154.4 0.0 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 EAK89441.1 - 1.3e-17 64.6 12.1 1.5e-17 64.5 8.6 2.9 2 1 0 2 2 2 1 rRNA-processing arch domain DEAD PF00270.29 EAK89441.1 - 6.8e-16 58.5 0.1 2.2e-15 56.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89441.1 - 4.7e-05 23.7 3.0 0.00025 21.3 0.0 3.6 3 1 0 3 3 3 1 Helicase conserved C-terminal domain Sushi PF00084.20 EAK89442.1 - 1.6e-05 25.4 1.3 3.9e-05 24.2 1.3 1.7 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Troponin PF00992.20 EAK89443.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Troponin SHMT PF00464.19 EAK89448.1 - 8.4e-122 406.6 0.0 1.3e-121 406.0 0.0 1.3 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Autophagy_N PF03986.13 EAK89450.1 - 2.3e-25 89.1 0.0 3.1e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EAK89450.1 - 1.6e-18 67.0 0.2 3.4e-18 66.0 0.2 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EAK89450.1 - 6e-10 38.4 0.8 1.4e-09 37.2 0.8 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal zf-Nse PF11789.8 EAK89451.1 - 5.1e-10 39.0 0.6 9.5e-10 38.1 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Phage_glycop_gL PF11108.8 EAK89452.1 - 0.14 12.2 2.8 0.36 10.9 1.0 2.7 2 0 0 2 2 2 0 Viral glycoprotein L GMC_oxred_C PF05199.13 EAK89454.1 - 3.3e-23 82.8 0.0 7.8e-23 81.6 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EAK89454.1 - 2.5e-21 76.3 0.1 3.7e-11 42.9 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase Pyr_redox_2 PF07992.14 EAK89454.1 - 6.3e-05 22.3 0.1 0.00011 21.6 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EAK89454.1 - 7.3e-05 23.3 0.3 0.00078 20.0 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 EAK89454.1 - 0.00012 20.7 0.0 0.0002 20.0 0.0 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor FAD_binding_2 PF00890.24 EAK89454.1 - 0.00016 20.9 0.0 0.00024 20.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EAK89454.1 - 0.0004 19.7 0.0 0.00064 19.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EAK89454.1 - 0.00046 20.4 0.1 0.00046 20.4 0.1 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EAK89454.1 - 0.00055 19.6 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EAK89454.1 - 0.00072 18.9 0.1 0.0019 17.5 0.0 1.7 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EAK89454.1 - 0.0028 16.4 0.0 0.0043 15.8 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EAK89454.1 - 0.0029 16.8 0.2 0.0045 16.1 0.2 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EAK89454.1 - 0.0091 15.1 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DUF4847 PF16139.5 EAK89454.1 - 0.0091 15.9 0.1 0.025 14.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4847) FAD_oxidored PF12831.7 EAK89454.1 - 0.0095 15.3 0.1 0.014 14.8 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EAK89454.1 - 0.023 13.9 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EAK89454.1 - 0.075 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-HIT PF04438.16 EAK89455.1 - 0.001 18.9 7.6 0.001 18.9 7.6 1.7 2 0 0 2 2 2 1 HIT zinc finger Com_YlbF PF06133.11 EAK89455.1 - 0.21 12.2 7.9 0.49 11.0 6.0 2.3 1 1 1 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Peptidase_M16_C PF05193.21 EAK89457.1 - 6e-12 45.9 1.1 1.4e-09 38.2 0.0 3.3 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK89457.1 - 8e-10 38.9 0.0 4e-09 36.6 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) SET PF00856.28 EAK89458.1 - 1.3e-17 64.7 0.5 1.1e-16 61.6 0.5 2.8 1 0 0 1 1 1 1 SET domain PHD PF00628.29 EAK89458.1 - 2.7e-12 46.4 93.9 8.4e-06 25.6 8.0 9.5 8 1 1 9 9 9 7 PHD-finger Bromodomain PF00439.25 EAK89458.1 - 3.5e-10 39.8 1.5 4.1e-09 36.4 1.5 3.1 1 0 0 1 1 1 1 Bromodomain C1_1 PF00130.22 EAK89458.1 - 0.001 18.9 2.3 0.001 18.9 2.3 8.5 6 2 3 9 9 9 5 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3903 PF13043.6 EAK89459.1 - 0.2 11.5 1.7 1.4 8.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3903) Prefoldin_3 PF13758.6 EAK89460.1 - 0.19 11.8 1.4 0.58 10.3 0.7 2.1 2 1 0 2 2 2 0 Prefoldin subunit SNF2_N PF00176.23 EAK89461.1 - 2.6e-67 227.0 0.2 5.2e-67 226.0 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK89461.1 - 5.1e-17 62.2 0.0 2.2e-16 60.2 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SLIDE PF09111.10 EAK89461.1 - 0.0066 16.5 0.5 0.0066 16.5 0.5 3.1 3 0 0 3 3 3 1 SLIDE Myb_DNA-binding PF00249.31 EAK89461.1 - 0.032 14.4 1.6 1.5 9.1 0.0 3.7 2 1 1 3 3 3 0 Myb-like DNA-binding domain Astro_capsid_p PF12226.8 EAK89461.1 - 0.52 9.4 19.3 0.0082 15.3 11.6 1.9 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Myb_DNA-binding PF00249.31 EAK89462.1 - 0.0059 16.8 0.1 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Zn_Tnp_IS91 PF14319.6 EAK89462.1 - 0.086 12.9 0.7 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 Transposase zinc-binding domain PH PF00169.29 EAK89463.1 - 0.00017 22.1 1.7 0.00074 20.0 0.1 3.1 3 0 0 3 3 3 1 PH domain Notch PF00066.17 EAK89464.1 - 1.4e-36 124.6 120.4 1.1e-07 32.2 14.5 6.3 4 1 2 6 6 6 6 LNR domain DnaJ PF00226.31 EAK89465.1 - 8.5e-19 67.5 0.2 1.6e-18 66.5 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DUF2298 PF10060.9 EAK89465.1 - 0.14 10.8 0.8 3.7 6.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) DUF5638 PF18688.1 EAK89465.1 - 0.43 10.9 6.2 1.2 9.5 0.2 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5638) LRR_4 PF12799.7 EAK89466.1 - 5.6e-07 29.8 54.8 0.0012 19.1 1.2 8.2 4 2 2 8 8 8 7 Leucine Rich repeats (2 copies) DnaJ PF00226.31 EAK89469.1 - 1.2e-06 28.5 0.3 3.9e-06 26.9 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain CBM_21 PF03370.13 EAK89469.1 - 0.26 11.4 7.7 2.3 8.4 0.2 3.4 2 1 1 3 3 3 0 Carbohydrate/starch-binding module (family 21) SUI1 PF01253.22 EAK89470.1 - 2.9e-21 75.8 1.4 3e-21 75.7 0.2 1.6 2 0 0 2 2 2 1 Translation initiation factor SUI1 FTO_NTD PF12933.7 EAK89470.1 - 0.083 12.1 1.7 0.1 11.8 1.7 1.1 1 0 0 1 1 1 0 FTO catalytic domain SNRNP27 PF08648.12 EAK89471.1 - 3.8e-23 81.3 0.2 1.3e-22 79.6 0.2 1.9 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins C2 PF00168.30 EAK89472.1 - 8.2e-33 112.8 0.0 2.8e-07 30.7 0.0 5.8 5 0 0 5 5 5 5 C2 domain Ferlin_C PF16165.5 EAK89472.1 - 7.5e-07 29.2 0.0 2.4e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 Ferlin C-terminus FerI PF08151.12 EAK89472.1 - 0.0093 16.0 0.2 0.7 10.0 0.0 3.0 2 0 0 2 2 2 1 FerI (NUC094) domain Snf7 PF03357.21 EAK89473.1 - 1.4e-10 41.1 12.1 2.6e-10 40.2 12.1 1.4 1 0 0 1 1 1 1 Snf7 Lung_7-TM_R PF06814.13 EAK89474.1 - 8.1e-37 127.1 25.7 1.1e-36 126.6 25.7 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor MA3 PF02847.17 EAK89475.1 - 2e-20 72.8 3.1 2e-20 72.8 3.1 2.1 2 0 0 2 2 2 1 MA3 domain GST_C_3 PF14497.6 EAK89476.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain EXS PF03124.14 EAK89477.1 - 3.4e-70 237.0 30.3 4.9e-70 236.5 30.3 1.2 1 0 0 1 1 1 1 EXS family AAA_23 PF13476.6 EAK89478.1 - 6.8e-16 59.4 1.5 6.8e-16 59.4 1.5 6.7 1 1 3 4 4 4 1 AAA domain SMC_N PF02463.19 EAK89478.1 - 2.1e-11 43.7 37.3 3.8e-10 39.6 37.3 2.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EAK89478.1 - 6.4e-06 26.2 11.3 2.8e-05 24.1 3.5 4.7 3 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EAK89478.1 - 0.00016 21.3 0.2 0.00039 20.1 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain V-set_2 PF15910.5 EAK89478.1 - 0.022 14.9 0.4 0.022 14.9 0.4 3.4 3 0 0 3 3 3 0 ICOS V-set domain FtsK_SpoIIIE PF01580.18 EAK89478.1 - 0.23 10.8 2.2 4.8 6.5 0.0 2.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Img2 PF05046.14 EAK89478.1 - 0.41 11.0 3.0 1.1 9.6 0.6 3.1 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) TraF_2 PF13729.6 EAK89478.1 - 5.1 6.4 5.7 8.5 5.7 0.0 3.4 3 0 0 3 3 3 0 F plasmid transfer operon, TraF, protein Neur_chan_memb PF02932.16 EAK89479.1 - 5.5 7.0 6.6 25 4.8 6.3 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Alpha_adaptinC2 PF02883.20 EAK89482.1 - 3.2e-06 27.4 0.1 1.1e-05 25.7 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain SNF2_N PF00176.23 EAK89483.1 - 3e-69 233.4 2.7 5.6e-69 232.5 2.7 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAK89483.1 - 5.3e-20 71.8 2.9 6.1e-20 71.6 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EAK89483.1 - 3.2e-09 37.0 2.8 1.3e-08 35.0 2.8 2.1 1 0 0 1 1 1 1 HSA Cas9_C PF18525.1 EAK89483.1 - 0.11 12.7 0.3 0.55 10.4 0.3 2.2 1 0 0 1 1 1 0 Cas9 C-terminal domain tRNA-synt_1 PF00133.22 EAK89484.1 - 2.3e-179 597.5 0.1 7.9e-178 592.4 0.0 2.4 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EAK89484.1 - 8.2e-30 103.8 0.2 8.2e-30 103.8 0.2 2.3 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EAK89484.1 - 3.3e-15 55.7 3.6 9.5e-08 31.2 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EAK89484.1 - 5.9e-07 29.2 0.2 1.1e-05 25.0 0.0 2.4 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EAK89484.1 - 0.0014 18.1 1.7 0.018 14.4 0.0 3.0 4 0 0 4 4 4 1 tRNA synthetases class I (C) catalytic domain Coagulase PF08764.10 EAK89484.1 - 0.018 15.3 1.8 0.044 14.0 1.8 1.6 1 0 0 1 1 1 0 Staphylococcus aureus coagulase tRNA-synt_1b PF00579.25 EAK89484.1 - 0.084 12.2 0.1 0.66 9.2 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) DUF4358 PF14270.6 EAK89484.1 - 6.6 7.1 6.8 18 5.7 2.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) PA28_beta PF02252.18 EAK89485.1 - 2.4e-56 189.4 0.3 2.4e-56 189.4 0.3 1.4 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 EAK89485.1 - 0.031 14.3 0.1 0.099 12.7 0.0 1.9 2 0 0 2 2 2 0 Proteasome activator pa28 alpha subunit Babuvirus_MP PF07234.11 EAK89485.1 - 0.12 12.5 0.0 15 5.8 0.0 2.2 2 0 0 2 2 2 0 Movement and RNA silencing protein GATA PF00320.27 EAK89486.1 - 0.019 14.6 7.3 1 9.0 7.3 2.8 1 1 0 1 1 1 0 GATA zinc finger DUF4327 PF14217.6 EAK89486.1 - 0.14 12.3 0.0 0.41 10.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4327) AP2 PF00847.20 EAK89488.1 - 9.9e-15 54.5 3.4 2.1e-14 53.5 3.4 1.5 1 0 0 1 1 1 1 AP2 domain ParA PF10609.9 EAK89489.1 - 2.7e-84 282.5 0.4 3.4e-84 282.2 0.4 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EAK89489.1 - 4.1e-11 43.0 0.0 6.7e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EAK89489.1 - 4.7e-09 36.4 0.0 1.3e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EAK89489.1 - 3.8e-06 26.3 2.7 0.00015 21.1 0.1 2.6 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 EAK89489.1 - 2.5e-05 23.7 0.0 7.3e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 ATPase MipZ NB-ARC PF00931.22 EAK89489.1 - 0.0018 17.5 1.2 0.0039 16.4 0.4 1.8 1 1 1 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 EAK89489.1 - 0.0063 16.4 0.9 0.029 14.3 0.2 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_26 PF13500.6 EAK89489.1 - 0.021 14.6 0.4 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain CBP_BcsQ PF06564.12 EAK89489.1 - 0.083 12.4 0.0 0.18 11.2 0.0 1.7 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EAK89489.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase SRP54 PF00448.22 EAK89489.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EAK89489.1 - 0.15 11.6 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNase_H2_suC PF08615.11 EAK89490.1 - 3.7e-08 33.6 1.4 1.1e-06 28.9 0.1 1.9 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Condensin2nSMC PF12422.8 EAK89491.1 - 2.2e-40 138.3 3.1 2.9e-40 137.9 0.4 2.7 2 0 0 2 2 2 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 EAK89491.1 - 1.6e-06 27.8 1.0 0.11 12.8 0.1 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EAK89491.1 - 0.077 13.4 0.0 1.9 8.9 0.0 3.0 2 1 1 3 3 3 0 HEAT repeats ERO1 PF04137.15 EAK89492.1 - 1.8e-27 96.5 5.1 6.9e-24 84.7 5.1 3.0 1 1 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Sec20 PF03908.13 EAK89492.1 - 2.8 7.9 6.5 1.9 8.5 3.8 2.0 2 0 0 2 2 2 0 Sec20 Peptidase_C12 PF01088.21 EAK89493.1 - 4.3e-41 141.0 0.0 4.9e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UvrD-helicase PF00580.21 EAK89494.1 - 5.8e-53 180.5 4.4 5.8e-53 180.5 4.4 2.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EAK89494.1 - 1.1e-40 140.1 8.9 1.1e-40 140.1 8.9 3.3 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EAK89494.1 - 2.7e-24 86.1 0.0 9.1e-24 84.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EAK89494.1 - 7.9e-11 41.6 0.2 9.9e-10 38.1 0.2 2.3 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EAK89494.1 - 8.5e-06 25.6 0.0 9.4e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EAK89494.1 - 0.0024 17.5 7.6 0.03 14.0 0.3 3.6 3 1 0 3 3 3 2 AAA domain ResIII PF04851.15 EAK89494.1 - 0.006 16.6 0.0 0.006 16.6 0.0 3.0 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EAK89494.1 - 0.044 13.5 0.1 1.6 8.4 0.0 2.9 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Terminase_6 PF03237.15 EAK89494.1 - 0.059 13.0 0.2 4.7 6.8 0.0 3.6 4 1 1 5 5 5 0 Terminase-like family AAA_11 PF13086.6 EAK89494.1 - 0.31 10.8 0.0 0.31 10.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF3223 PF11523.8 EAK89495.1 - 4.4e-18 65.9 1.9 3.1e-17 63.2 0.8 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3223) La PF05383.17 EAK89495.1 - 1.5e-14 53.7 0.2 4.5e-14 52.2 0.2 1.9 1 0 0 1 1 1 1 La domain RRM_3 PF08777.11 EAK89495.1 - 0.022 14.8 2.8 0.024 14.7 0.1 2.3 3 0 0 3 3 3 0 RNA binding motif AP2 PF00847.20 EAK89496.1 - 2.8e-12 46.7 3.1 5.7e-12 45.7 3.1 1.6 1 0 0 1 1 1 1 AP2 domain DDHD PF02862.17 EAK89497.1 - 0.019 15.1 1.2 0.038 14.2 1.2 1.5 1 0 0 1 1 1 0 DDHD domain ABC1 PF03109.16 EAK89498.1 - 1e-26 93.4 0.0 3.7e-26 91.6 0.0 2.0 2 0 0 2 2 2 1 ABC1 family DnaJ-X PF14308.6 EAK89499.1 - 7.7e-47 159.5 6.4 1.8e-46 158.2 6.4 1.6 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 EAK89499.1 - 5.1e-24 84.2 6.1 1.2e-23 83.0 6.1 1.7 1 0 0 1 1 1 1 DnaJ domain ATG_C PF09333.11 EAK89499.1 - 4.3e-06 27.0 0.1 1.8e-05 25.0 0.1 2.1 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain DUF834 PF05754.14 EAK89499.1 - 0.22 11.6 4.0 0.69 10.0 4.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF834) Antimicrobial_2 PF08023.12 EAK89499.1 - 0.68 10.5 3.1 3.8 8.1 1.6 2.7 2 0 0 2 2 2 0 Frog antimicrobial peptide Methyltransf_31 PF13847.6 EAK89500.1 - 6e-15 55.3 0.0 8.9e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK89500.1 - 4e-12 46.6 0.0 6.6e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAK89500.1 - 1.4e-11 44.9 0.0 2.4e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK89500.1 - 1.7e-10 41.0 0.0 2.4e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK89500.1 - 5.9e-10 39.8 0.0 1.8e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EAK89500.1 - 2.5e-05 23.7 0.0 3.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EAK89500.1 - 5.5e-05 22.6 0.0 7.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Pox_MCEL PF03291.16 EAK89500.1 - 0.0003 20.0 0.0 0.00037 19.7 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme MTS PF05175.14 EAK89500.1 - 0.036 13.6 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EAK89500.1 - 0.068 12.6 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_24 PF13578.6 EAK89500.1 - 0.15 13.1 0.0 0.26 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EAK89500.1 - 0.2 11.5 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Kinesin PF00225.23 EAK89501.1 - 1.1e-91 307.3 7.1 1.8e-91 306.6 7.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EAK89501.1 - 2.4e-18 66.5 2.5 7.8e-18 64.8 2.5 1.9 1 0 0 1 1 1 1 Microtubule binding PhoH PF02562.16 EAK89501.1 - 0.026 14.0 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 EAK89501.1 - 0.058 13.4 0.7 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit EF-G-binding_N PF07299.11 EAK89501.1 - 6.2 7.4 7.9 0.46 11.0 0.3 3.1 3 1 1 4 4 4 0 Elongation factor G-binding protein, N-terminal eIF-1a PF01176.19 EAK89502.1 - 7.4e-24 83.3 0.0 1.2e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 CBM_14 PF01607.24 EAK89503.1 - 0.083 13.1 42.4 0.25 11.5 1.1 9.3 7 2 3 10 10 10 0 Chitin binding Peritrophin-A domain Prok-E2_C PF14459.6 EAK89503.1 - 0.22 11.7 1.3 6.1 7.0 0.0 3.6 4 0 0 4 4 4 0 Prokaryotic E2 family C FOG_N PF15888.5 EAK89503.1 - 0.54 10.6 33.3 11 6.5 0.1 9.8 7 2 3 10 10 10 0 Folded gastrulation N-terminus cEGF PF12662.7 EAK89503.1 - 1.9 8.5 29.6 1.5 8.8 0.5 8.8 9 0 0 9 9 9 0 Complement Clr-like EGF-like UL45 PF05473.12 EAK89503.1 - 4.9 6.8 8.8 8 6.0 0.4 3.5 3 1 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like PWI PF01480.17 EAK89504.1 - 3.5e-21 75.3 0.1 9.3e-21 73.9 0.1 1.7 1 0 0 1 1 1 1 PWI domain Chordopox_G3 PF06129.12 EAK89504.1 - 0.13 13.0 2.7 8 7.2 0.1 2.8 3 0 0 3 3 3 0 Chordopoxvirus G3 protein Ribosomal_L26 PF16906.5 EAK89504.1 - 0.57 10.7 6.3 0.11 13.0 0.8 2.6 3 1 0 3 3 3 0 Ribosomal proteins L26 eukaryotic, L24P archaeal MCM_bind PF09739.9 EAK89505.1 - 5.6e-33 114.3 11.2 5.8e-33 114.2 8.5 2.0 1 1 1 2 2 2 2 Mini-chromosome maintenance replisome factor NUC173 PF08161.12 EAK89506.1 - 4.4e-29 101.6 0.0 4.4e-29 101.6 0.0 3.6 4 1 0 4 4 4 1 NUC173 domain Brix PF04427.18 EAK89507.1 - 1.3e-38 133.1 0.0 1.8e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain NIF PF03031.18 EAK89508.1 - 4.2e-23 81.9 0.0 9.3e-23 80.7 0.0 1.6 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase Elf4 PF07011.11 EAK89508.1 - 0.021 14.7 0.3 0.051 13.5 0.3 1.6 1 0 0 1 1 1 0 Early Flowering 4 domain DUF3458_C PF17432.2 EAK89509.1 - 6.3e-54 183.5 0.0 8.8e-54 183.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 EAK89509.1 - 8.4e-45 153.0 0.1 1.3e-44 152.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 EAK89509.1 - 7.6e-24 84.0 0.0 2e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 EAK89509.1 - 3e-09 37.3 0.0 5.7e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Ribosomal_L22 PF00237.19 EAK89510.1 - 1.5e-29 102.2 0.0 2.4e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e zf-RING_2 PF13639.6 EAK89511.1 - 1.8e-11 44.2 9.1 3.6e-11 43.2 9.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EAK89511.1 - 1.4e-08 34.3 8.9 3.6e-08 33.0 8.3 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EAK89511.1 - 8.6e-08 32.4 9.8 5.9e-07 29.7 9.8 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EAK89511.1 - 3.3e-07 30.1 8.7 6.5e-07 29.1 8.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK89511.1 - 1.3e-05 24.9 7.9 2.7e-05 23.9 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK89511.1 - 6e-05 22.9 5.8 6e-05 22.9 5.8 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EAK89511.1 - 0.00065 19.5 5.9 0.00065 19.5 5.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK89511.1 - 0.00075 19.5 7.6 0.0019 18.1 7.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EAK89511.1 - 0.0016 18.0 5.6 0.0032 17.0 5.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_9 PF13901.6 EAK89511.1 - 0.008 16.2 4.0 0.41 10.6 3.4 2.8 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon Prok-RING_4 PF14447.6 EAK89511.1 - 0.013 15.3 7.9 0.013 15.3 7.9 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EAK89511.1 - 0.054 13.6 4.2 0.17 11.9 4.2 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 EAK89511.1 - 0.081 13.1 4.3 0.05 13.8 1.9 1.9 2 0 0 2 2 2 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 EAK89511.1 - 0.24 11.5 5.0 0.55 10.3 5.0 1.7 1 0 0 1 1 1 0 Zinc-finger C1_2 PF03107.16 EAK89511.1 - 0.33 11.3 3.6 0.96 9.8 3.6 1.8 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 EAK89511.1 - 0.37 10.7 6.7 0.77 9.7 6.7 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EAK89511.1 - 0.38 11.1 2.6 0.78 10.1 2.6 1.5 1 0 0 1 1 1 0 RING-like domain C1_1 PF00130.22 EAK89511.1 - 0.38 10.7 5.9 0.16 11.9 2.9 2.0 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EAK89511.1 - 0.52 10.5 4.2 1.1 9.4 4.2 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger RINGv PF12906.7 EAK89511.1 - 0.6 10.3 6.3 1.3 9.2 6.3 1.6 1 0 0 1 1 1 0 RING-variant domain RsmJ PF04378.13 EAK89512.1 - 0.091 12.0 0.2 0.13 11.4 0.2 1.2 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ Terminase_6 PF03237.15 EAK89512.1 - 0.17 11.5 0.7 0.4 10.3 0.8 1.6 1 1 0 1 1 1 0 Terminase-like family Bac_DNA_binding PF00216.21 EAK89513.1 - 0.01 16.0 0.9 5.8 7.2 0.1 3.4 2 0 0 2 2 2 0 Bacterial DNA-binding protein FapA PF03961.13 EAK89514.1 - 0.27 9.8 1.7 0.5 8.9 1.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A KSHV_K8 PF07188.11 EAK89516.1 - 0.071 12.5 0.2 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein Gate PF07670.14 EAK89517.1 - 0.092 13.0 0.8 1.4 9.2 0.8 2.1 1 1 0 1 1 1 0 Nucleoside recognition dUTPase_2 PF08761.11 EAK89518.1 - 1.3 9.2 5.3 0.25 11.5 0.2 2.3 3 0 0 3 3 3 0 dUTPase BAR PF03114.18 EAK89520.1 - 0.0039 16.9 6.6 0.0039 16.9 6.6 1.7 2 0 0 2 2 2 1 BAR domain XhlA PF10779.9 EAK89520.1 - 0.04 14.1 0.3 0.04 14.1 0.3 2.1 2 0 0 2 2 2 0 Haemolysin XhlA SseC PF04888.12 EAK89520.1 - 5.1 6.6 5.0 7.4 6.1 5.0 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family AAA_11 PF13086.6 EAK89520.1 - 8.4 6.1 9.1 11 5.8 9.1 1.3 1 1 0 1 1 1 0 AAA domain Patched PF02460.18 EAK89524.1 - 9.3e-21 73.6 29.0 1.4e-11 43.3 18.2 3.5 3 1 0 3 3 3 3 Patched family Sterol-sensing PF12349.8 EAK89524.1 - 1.3e-10 41.3 0.1 1.3e-10 41.3 0.1 3.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation HemY_N PF07219.13 EAK89524.1 - 2.1 8.6 5.0 4.5 7.5 0.1 3.4 4 0 0 4 4 4 0 HemY protein N-terminus DIM1 PF02966.16 EAK89526.1 - 9.4e-65 216.4 0.7 1.1e-64 216.2 0.7 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EAK89526.1 - 0.0064 16.5 0.0 0.0086 16.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin CCDC53 PF10152.9 EAK89528.1 - 0.61 10.5 8.3 0.73 10.2 3.5 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex ER PF01133.17 EAK89529.1 - 0.0027 17.7 2.4 0.012 15.6 2.4 2.0 1 1 0 1 1 1 1 Enhancer of rudimentary DUF1128 PF06569.11 EAK89529.1 - 0.1 12.6 1.2 0.22 11.5 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) zf-CCHC_2 PF13696.6 EAK89530.1 - 1.4e-08 34.4 5.4 2.6e-08 33.5 5.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-RING_UBOX PF13445.6 EAK89530.1 - 0.0011 19.0 3.9 0.0028 17.6 3.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EAK89530.1 - 0.0053 16.6 5.1 0.0053 16.6 5.1 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAK89530.1 - 0.006 16.4 7.6 0.006 16.4 7.6 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK89530.1 - 0.0066 16.8 8.8 0.0066 16.8 8.8 2.0 2 0 0 2 2 2 1 Ring finger domain DWNN PF08783.11 EAK89530.1 - 0.017 15.4 0.2 0.048 13.9 0.2 1.8 1 0 0 1 1 1 0 DWNN domain zf-C3HC4_4 PF15227.6 EAK89530.1 - 0.018 15.2 8.5 0.12 12.5 8.9 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-CCHC PF00098.23 EAK89530.1 - 0.25 11.5 3.9 0.6 10.3 3.9 1.7 1 0 0 1 1 1 0 Zinc knuckle Rubredoxin PF00301.20 EAK89530.1 - 0.57 10.3 3.6 16 5.6 0.0 3.9 3 1 0 3 3 3 0 Rubredoxin FANCL_C PF11793.8 EAK89530.1 - 0.59 10.4 5.6 1.7 8.9 5.6 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_5 PF14634.6 EAK89530.1 - 1.1 9.2 15.6 0.17 11.9 9.2 2.3 2 0 0 2 2 2 0 zinc-RING finger domain Aa_trans PF01490.18 EAK89531.1 - 2.4e-52 178.1 43.3 2.9e-52 177.8 43.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EAK89531.1 - 0.016 14.3 39.2 0.092 11.8 38.6 1.9 1 1 0 1 1 1 0 Tryptophan/tyrosine permease family Y_Y_Y PF07495.13 EAK89533.1 - 0.12 12.3 3.0 1.3 9.0 0.1 3.8 4 0 0 4 4 4 0 Y_Y_Y domain SNARE PF05739.19 EAK89534.1 - 0.21 11.6 2.8 0.27 11.2 1.6 1.8 2 0 0 2 2 2 0 SNARE domain EMP24_GP25L PF01105.24 EAK89534.1 - 0.67 9.9 3.6 1.1 9.2 3.6 1.5 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD CRAL_TRIO PF00650.20 EAK89535.1 - 3e-30 105.0 0.1 4.1e-30 104.6 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EAK89535.1 - 0.00015 21.9 0.0 0.00031 20.9 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain IQ PF00612.27 EAK89535.1 - 0.003 17.2 0.0 0.007 16.1 0.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif AATF-Che1 PF13339.6 EAK89536.1 - 1.4e-13 51.7 3.0 1.4e-13 51.7 3.0 1.7 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor Dcc1 PF09724.9 EAK89537.1 - 7.5e-31 107.6 0.8 9.9e-30 104.0 0.8 2.3 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Ntox27 PF15531.6 EAK89538.1 - 0.14 12.0 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial toxin 27 Tsc35 PF15079.6 EAK89539.1 - 0.026 14.1 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Testis-specific protein 35 CpxA_peri PF16527.5 EAK89539.1 - 0.12 12.7 0.2 1.2 9.5 0.0 2.1 2 0 0 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain ING PF12998.7 EAK89539.1 - 1.2 9.8 4.8 1 10.0 2.4 2.2 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding YbaB_DNA_bd PF02575.16 EAK89540.1 - 0.11 12.8 0.2 0.51 10.6 0.0 2.1 2 0 0 2 2 2 0 YbaB/EbfC DNA-binding family Fe_hyd_SSU PF02256.17 EAK89540.1 - 0.12 12.5 0.9 0.56 10.3 0.1 2.5 2 0 0 2 2 2 0 Iron hydrogenase small subunit UPF0449 PF15136.6 EAK89540.1 - 0.14 12.6 0.2 6 7.4 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Patatin PF01734.22 EAK89541.1 - 1.4e-07 32.0 0.0 0.00015 22.0 0.1 2.5 2 0 0 2 2 2 2 Patatin-like phospholipase Patatin PF01734.22 EAK89542.1 - 1.5e-22 80.8 0.5 1e-21 78.1 0.5 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase Aa_trans PF01490.18 EAK89543.1 - 7.1e-10 38.2 45.9 1.4e-05 24.0 30.0 2.3 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein MFS_1 PF07690.16 EAK89544.1 - 9.7e-45 153.0 28.6 2.3e-43 148.5 24.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Tmemb_18A PF09771.9 EAK89544.1 - 2.5 8.5 4.9 18 5.7 0.0 3.4 4 0 0 4 4 4 0 Transmembrane protein 188 MMR_HSR1 PF01926.23 EAK89546.1 - 2e-10 40.7 0.0 1.1e-09 38.4 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EAK89546.1 - 1.4e-08 34.9 0.1 2e-06 27.9 0.1 2.8 1 1 0 1 1 1 1 Dynamin family GTP_EFTU PF00009.27 EAK89546.1 - 4.1e-07 29.7 0.0 1.4e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EAK89546.1 - 9.8e-05 22.3 0.9 0.0028 17.6 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase ABC_tran PF00005.27 EAK89546.1 - 0.0028 18.2 1.3 0.0063 17.0 0.8 2.0 1 1 0 1 1 1 1 ABC transporter Roc PF08477.13 EAK89546.1 - 0.0031 17.7 0.1 0.013 15.8 0.1 2.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EAK89546.1 - 0.0033 16.9 0.1 0.0096 15.4 0.1 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EAK89546.1 - 0.0034 16.7 0.1 0.0034 16.7 0.1 2.0 2 1 0 2 2 2 1 Septin PduV-EutP PF10662.9 EAK89546.1 - 0.02 14.6 3.3 1.1 9.0 0.1 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EAK89546.1 - 0.037 13.6 0.4 0.85 9.1 0.1 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AIG1 PF04548.16 EAK89546.1 - 0.046 13.0 4.9 0.54 9.6 0.0 2.9 3 0 0 3 3 3 0 AIG1 family AAA_29 PF13555.6 EAK89546.1 - 0.1 12.4 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 EAK89546.1 - 0.19 11.3 2.7 3.5 7.2 0.1 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain NTP_transferase PF00483.23 EAK89547.1 - 1.4e-13 51.1 0.0 5.6e-13 49.0 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EAK89547.1 - 9.2e-11 41.0 10.9 5.7e-05 22.7 5.6 3.1 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EAK89547.1 - 2.9e-06 27.7 0.0 5.8e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EAK89547.1 - 0.00058 18.1 1.7 0.00098 17.4 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EAK89547.1 - 0.0053 16.5 12.5 0.069 12.9 6.8 3.5 1 1 2 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EAK89547.1 - 0.0088 15.0 5.5 0.033 13.1 5.6 1.6 1 1 0 1 1 1 1 L-fucokinase Seryl_tRNA_N PF02403.22 EAK89548.1 - 0.0061 16.8 1.3 0.009 16.2 1.3 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Syntaxin PF00804.25 EAK89548.1 - 0.21 11.2 7.1 0.28 10.8 7.1 1.2 1 0 0 1 1 1 0 Syntaxin PI3K_1B_p101 PF10486.9 EAK89548.1 - 8.1 4.1 13.8 8.3 4.0 13.8 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1640 PF07798.11 EAK89549.1 - 0.016 15.2 2.1 0.033 14.2 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) HALZ PF02183.18 EAK89549.1 - 0.042 14.1 3.6 3.7 7.8 0.1 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Cnn_1N PF07989.11 EAK89549.1 - 0.088 13.0 5.7 2.9 8.1 0.4 3.3 2 1 0 3 3 3 0 Centrosomin N-terminal motif 1 Herpes_BLRF2 PF05812.12 EAK89549.1 - 0.096 12.8 1.7 8.5 6.5 0.2 2.7 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein bZIP_1 PF00170.21 EAK89549.1 - 0.098 12.8 5.1 5.3 7.2 0.1 3.4 3 0 0 3 3 3 0 bZIP transcription factor Fungal_TACC PF12709.7 EAK89549.1 - 0.29 11.6 3.0 15 6.1 0.1 3.3 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins bZIP_2 PF07716.15 EAK89549.1 - 0.37 10.9 5.9 7.9 6.7 0.5 3.4 3 0 0 3 3 3 0 Basic region leucine zipper GIT_CC PF16559.5 EAK89549.1 - 0.43 10.5 2.9 8.2 6.4 0.1 3.3 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 EAK89549.1 - 0.52 11.0 9.1 3.3 8.4 0.2 3.3 1 1 2 3 3 3 0 Initiation control protein YabA NRBF2 PF08961.10 EAK89549.1 - 0.66 9.5 5.0 2.1 7.9 1.2 2.4 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 EAK89549.1 - 1.1 9.1 4.4 22 4.9 0.1 2.9 3 0 0 3 3 3 0 Septum formation initiator ZapB PF06005.12 EAK89549.1 - 1.1 9.8 11.0 8.8 6.8 5.1 3.5 1 1 1 2 2 2 0 Cell division protein ZapB LMBR1 PF04791.16 EAK89549.1 - 2.3 7.0 5.1 2.2 7.1 3.9 1.5 1 1 1 2 2 2 0 LMBR1-like membrane protein PRKG1_interact PF15898.5 EAK89549.1 - 2.3 9.2 11.3 9 7.3 0.3 3.2 3 1 1 4 4 4 0 cGMP-dependent protein kinase interacting domain Cep57_CLD_2 PF14197.6 EAK89549.1 - 2.3 8.4 10.4 7.5 6.7 0.3 3.9 4 0 0 4 4 4 0 Centrosome localisation domain of PPC89 Rootletin PF15035.6 EAK89549.1 - 3.4 7.6 10.2 4.1 7.4 0.4 2.8 2 2 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion cNMP_binding PF00027.29 EAK89550.1 - 3e-23 81.7 0.0 6.2e-05 23.0 0.0 4.8 5 0 0 5 5 5 4 Cyclic nucleotide-binding domain tRNA-synt_His PF13393.6 EAK89551.1 - 3.4e-46 158.0 0.0 4.9e-46 157.4 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EAK89551.1 - 2.6e-12 46.7 0.0 7.8e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EAK89551.1 - 0.00019 20.6 0.0 0.0036 16.4 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EAK89551.1 - 0.00045 20.2 2.6 0.00045 20.2 2.6 2.3 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 EAK89551.1 - 0.00079 19.0 0.0 0.0019 17.8 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs DUF5601 PF18151.1 EAK89551.1 - 2.5 8.5 10.2 7.2 7.0 0.7 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5601) Filamin PF00630.19 EAK89552.1 - 2.4e-29 102.2 8.5 3.8e-25 88.7 0.0 4.6 5 0 0 5 5 5 3 Filamin/ABP280 repeat WD40 PF00400.32 EAK89554.1 - 1.6e-12 47.7 4.0 0.57 11.1 0.1 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK89554.1 - 1.9e-08 34.4 0.3 0.2 12.0 0.0 5.1 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PsbQ PF05757.11 EAK89554.1 - 0.0053 16.5 0.0 0.0091 15.8 0.0 1.4 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) Myb_DNA-bind_6 PF13921.6 EAK89555.1 - 0.00091 19.4 1.9 0.0033 17.6 1.3 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EAK89555.1 - 0.01 16.0 0.0 0.04 14.1 0.0 2.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF1772 PF08592.11 EAK89556.1 - 0.91 9.8 10.3 1.6 9.0 1.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) PspB PF06667.12 EAK89556.1 - 1.8 8.7 7.4 0.69 10.0 0.5 2.6 3 0 0 3 3 3 0 Phage shock protein B HA2 PF04408.23 EAK89557.1 - 1e-21 77.2 0.1 2.3e-21 76.1 0.1 1.7 1 1 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EAK89557.1 - 3.1e-20 72.3 0.0 6.5e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EAK89557.1 - 2.8e-12 47.0 0.0 8.1e-12 45.5 0.0 1.8 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EAK89557.1 - 2.5e-08 33.9 0.6 1.6e-07 31.3 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EAK89557.1 - 5.9e-06 26.6 0.1 1.9e-05 24.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EAK89557.1 - 0.0002 21.4 0.7 0.12 12.4 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EAK89557.1 - 0.0028 18.0 0.0 0.0058 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EAK89557.1 - 0.0059 16.3 0.1 0.016 14.9 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Pox_A32 PF04665.12 EAK89557.1 - 0.014 14.9 0.5 4.5 6.6 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_7 PF12775.7 EAK89557.1 - 0.025 14.1 0.0 0.071 12.6 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EAK89557.1 - 0.044 13.5 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EAK89557.1 - 0.053 13.0 0.0 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 EAK89557.1 - 0.065 12.6 0.1 0.15 11.4 0.1 1.5 1 0 0 1 1 1 0 KaiC Zeta_toxin PF06414.12 EAK89557.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 EAK89557.1 - 0.11 12.0 0.2 0.59 9.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EAK89557.1 - 0.14 12.6 0.4 0.41 11.2 0.0 1.9 2 0 0 2 2 1 0 ABC transporter T2SSE PF00437.20 EAK89557.1 - 0.15 11.1 0.0 0.33 10.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RasGEF_N PF00618.20 EAK89557.1 - 0.15 12.3 1.3 0.39 11.0 0.3 2.2 3 0 0 3 3 3 0 RasGEF N-terminal motif TsaE PF02367.17 EAK89557.1 - 0.16 12.0 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EAK89557.1 - 0.66 10.4 5.8 1 9.8 1.0 2.8 2 1 0 2 2 2 0 AAA domain Patatin PF01734.22 EAK89558.1 - 4.5e-19 69.4 0.4 5.1e-18 66.0 0.4 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase ELM2 PF01448.24 EAK89559.1 - 3.4e-07 30.9 0.0 6.3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 ELM2 domain CBF PF03914.17 EAK89562.1 - 6.3e-21 75.2 1.6 6.3e-21 75.2 1.6 3.3 3 2 0 3 3 3 1 CBF/Mak21 family Cnd1 PF12717.7 EAK89562.1 - 0.00057 20.0 0.7 0.00057 20.0 0.7 2.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_UF PF18817.1 EAK89562.1 - 0.053 13.8 1.1 0.34 11.2 0.0 2.7 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 TFCD_C PF12612.8 EAK89562.1 - 0.91 9.3 3.6 11 5.8 3.1 2.6 1 1 1 2 2 2 0 Tubulin folding cofactor D C terminal DASH_Dad3 PF08656.10 EAK89563.1 - 0.0023 18.0 0.2 0.0023 18.0 0.2 2.2 2 1 0 2 2 2 1 DASH complex subunit Dad3 DUF637 PF04830.13 EAK89563.1 - 0.14 11.9 4.4 0.14 12.0 2.8 1.7 1 1 0 1 1 1 0 Possible hemagglutinin (DUF637) LPD11 PF18824.1 EAK89564.1 - 7.4 6.7 12.6 2.7 8.1 0.9 3.6 3 2 0 3 3 3 0 Large polyvalent protein-associated domain 11 GMC_oxred_N PF00732.19 EAK89565.1 - 9.2e-11 41.6 0.0 5.8e-09 35.7 0.0 2.3 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EAK89565.1 - 1.4e-08 35.4 0.0 5.5e-05 23.7 0.0 2.6 2 0 0 2 2 2 2 GMC oxidoreductase DAO PF01266.24 EAK89565.1 - 0.001 18.7 0.0 0.0018 17.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EAK89565.1 - 0.0046 17.0 0.0 0.0083 16.1 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EAK89565.1 - 0.06 13.6 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF1764 PF08576.10 EAK89565.1 - 0.95 10.4 11.2 0.29 12.1 1.6 2.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) HMG_box PF00505.19 EAK89566.1 - 7.8e-15 55.1 2.8 1.3e-14 54.4 2.1 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EAK89566.1 - 7e-11 42.6 1.8 1.2e-10 41.9 1.8 1.4 1 0 0 1 1 1 1 HMG-box domain MMS1_N PF10433.9 EAK89567.1 - 3.1e-115 385.6 0.2 4.9e-115 384.9 0.2 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EAK89567.1 - 8.4e-74 248.8 0.3 5e-70 236.4 0.1 3.0 3 0 0 3 3 3 2 CPSF A subunit region DUF5031 PF16434.5 EAK89567.1 - 0.021 14.0 0.0 0.067 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5031) Rad60-SLD PF11976.8 EAK89568.1 - 2.3e-21 75.4 0.2 3.5e-21 74.8 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EAK89568.1 - 3.1e-11 42.9 0.0 4e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UBX PF00789.20 EAK89568.1 - 0.044 14.0 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 UBX domain PH PF00169.29 EAK89569.1 - 0.015 15.8 0.0 0.025 15.1 0.0 1.4 1 0 0 1 1 1 0 PH domain Fibrillarin PF01269.17 EAK89572.1 - 7.7e-106 352.3 0.0 9.3e-106 352.0 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EAK89572.1 - 3.8e-05 23.5 0.0 5.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 EAK89572.1 - 0.016 15.3 0.1 0.035 14.2 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EAK89572.1 - 0.035 13.8 0.0 0.095 12.3 0.0 1.7 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F DREV PF05219.12 EAK89572.1 - 0.062 12.4 0.0 0.081 12.0 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase PCMT PF01135.19 EAK89572.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UCH PF00443.29 EAK89573.1 - 3.4e-44 151.3 5.8 3.4e-44 151.3 5.8 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK89573.1 - 5.5e-23 82.1 7.8 5.5e-23 82.1 7.8 3.0 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-HIT PF04438.16 EAK89573.1 - 6.7 6.7 8.4 2 8.3 0.6 3.2 3 0 0 3 3 3 0 HIT zinc finger Ribosomal_L30 PF00327.20 EAK89574.1 - 9e-18 63.9 1.8 3.4e-17 62.1 1.8 2.1 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EAK89574.1 - 1.1e-11 44.8 3.4 1.9e-11 44.0 3.4 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Nop14 PF04147.12 EAK89575.1 - 1.3e-56 192.4 66.4 1e-46 159.7 55.9 2.4 2 1 0 2 2 2 2 Nop14-like family SKIP_SNW PF02731.15 EAK89576.1 - 1.8e-57 193.5 4.8 1.8e-57 193.5 4.8 2.4 2 0 0 2 2 2 1 SKIP/SNW domain DOR PF14839.6 EAK89576.1 - 0.027 14.4 1.7 0.069 13.1 1.7 1.7 1 0 0 1 1 1 0 DOR family Ac81 PF05820.11 EAK89577.1 - 1.2 8.7 4.0 2.2 7.8 4.0 1.4 1 0 0 1 1 1 0 Baculoviridae AC81 TFIIS_M PF07500.14 EAK89578.1 - 1.6e-24 86.5 1.9 1.6e-24 86.5 1.9 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EAK89578.1 - 1.2e-19 69.9 5.6 2.3e-19 68.9 5.6 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EAK89578.1 - 3.3e-09 36.6 1.3 3.3e-09 36.6 1.3 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain zinc_ribbon_4 PF13717.6 EAK89578.1 - 0.25 11.3 2.2 4.2 7.4 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain LOH1CR12 PF10158.9 EAK89578.1 - 0.94 9.5 9.5 2.8 8.0 2.1 2.7 3 0 0 3 3 3 0 Tumour suppressor protein Zip PF02535.22 EAK89578.1 - 1.9 7.7 8.4 3.9 6.6 8.4 1.7 1 1 0 1 1 1 0 ZIP Zinc transporter EIIBC-GUT_N PF03612.14 EAK89578.1 - 4.3 7.0 9.4 2.7 7.7 0.5 2.4 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3069 PF11269.8 EAK89579.1 - 0.052 13.8 0.2 0.14 12.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) zinc_ribbon_16 PF17034.5 EAK89580.1 - 8.5e-10 38.9 4.9 3.1e-09 37.1 4.9 2.0 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EAK89580.1 - 0.00012 21.7 8.9 0.00023 20.7 8.9 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Palm_thioest PF02089.15 EAK89580.1 - 0.0084 16.0 0.7 0.022 14.6 0.7 1.6 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Tn7_Tnp_TnsA_N PF08722.11 EAK89580.1 - 0.094 12.9 0.2 0.34 11.1 0.0 2.0 2 0 0 2 2 2 0 TnsA endonuclease N terminal zf-RING_2 PF13639.6 EAK89580.1 - 0.14 12.5 6.0 0.34 11.3 6.0 1.7 1 0 0 1 1 1 0 Ring finger domain eIF-5_eIF-2B PF01873.17 EAK89581.1 - 3.3e-35 120.5 0.0 5.9e-35 119.7 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Lar_restr_allev PF14354.6 EAK89581.1 - 0.0076 16.6 0.1 0.017 15.5 0.1 1.7 1 0 0 1 1 1 1 Restriction alleviation protein Lar TF_Zn_Ribbon PF08271.12 EAK89581.1 - 0.061 12.8 0.2 0.11 12.0 0.2 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Nudix_N_2 PF14803.6 EAK89581.1 - 0.18 11.7 1.8 0.36 10.8 1.8 1.4 1 0 0 1 1 1 0 Nudix N-terminal Acyl_transf_3 PF01757.22 EAK89582.1 - 2.1e-62 211.2 21.2 2.1e-62 211.2 21.2 2.1 1 1 1 2 2 2 1 Acyltransferase family Imm9 PF15587.6 EAK89582.1 - 0.0094 15.6 0.8 0.022 14.4 0.2 1.9 2 0 0 2 2 2 1 Immunity protein 9 DUF1772 PF08592.11 EAK89582.1 - 0.19 12.1 3.8 18 5.7 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) YwiC PF14256.6 EAK89582.1 - 8.4 6.7 12.6 0.091 13.1 2.4 2.9 3 2 0 3 3 3 0 YwiC-like protein DUF4551 PF15087.6 EAK89584.1 - 0.0022 16.9 8.3 0.0036 16.2 8.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) RP-C_C PF11800.8 EAK89584.1 - 0.62 10.1 4.4 1.5 8.9 4.4 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region PI3_PI4_kinase PF00454.27 EAK89585.1 - 4.6e-28 98.7 2.4 6.4e-26 91.7 0.7 2.8 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase NYD-SP28 PF14772.6 EAK89588.1 - 0.12 12.5 1.9 0.46 10.6 1.9 2.1 1 0 0 1 1 1 0 Sperm tail KASH_CCD PF14662.6 EAK89589.1 - 0.00022 21.1 27.6 0.00022 21.1 27.6 3.3 2 1 1 3 3 3 2 Coiled-coil region of CCDC155 or KASH CHDCT2 PF08074.11 EAK89589.1 - 0.00055 20.1 9.5 0.00055 20.1 9.5 3.4 2 1 1 3 3 3 1 CHDCT2 (NUC038) domain KLRAQ PF10205.9 EAK89589.1 - 0.0075 16.5 13.2 0.0075 16.5 13.2 4.8 2 1 2 4 4 4 1 Predicted coiled-coil domain-containing protein bZIP_1 PF00170.21 EAK89589.1 - 0.028 14.5 40.6 0.038 14.1 3.5 5.1 4 2 1 5 5 5 0 bZIP transcription factor HALZ PF02183.18 EAK89589.1 - 0.11 12.7 29.2 0.031 14.5 6.5 4.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper YabA PF06156.13 EAK89589.1 - 0.14 12.8 45.4 0.038 14.6 9.6 5.2 3 1 1 5 5 5 0 Initiation control protein YabA Mce4_CUP1 PF11887.8 EAK89589.1 - 1.5 8.2 4.7 2.3 7.6 3.8 1.7 1 1 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative ADIP PF11559.8 EAK89589.1 - 1.8 8.7 49.5 0.84 9.7 1.3 4.1 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 EAK89589.1 - 2.1 7.6 55.0 0.22 10.8 1.6 3.4 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding CALCOCO1 PF07888.11 EAK89589.1 - 3.4 6.4 33.4 1.2 7.9 27.4 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2053 PF09767.9 EAK89591.1 - 3e-12 47.0 6.7 3.6e-12 46.7 6.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) RE_AlwI PF09491.10 EAK89591.1 - 0.12 11.1 0.1 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease DUF3938 PF13074.6 EAK89591.1 - 0.25 11.6 2.9 0.39 11.0 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3938) Band_3_cyto PF07565.13 EAK89592.1 - 0.22 11.3 0.6 0.32 10.8 0.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Lsr2 PF11774.8 EAK89593.1 - 0.15 12.2 2.9 0.65 10.2 0.1 3.1 1 1 2 3 3 3 0 Lsr2 DUF1465 PF07323.12 EAK89593.1 - 2.1 8.1 13.4 0.17 11.7 1.6 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1465) Dynactin_p22 PF07426.11 EAK89594.1 - 4.3e-06 26.7 6.5 4.3e-06 26.7 6.5 2.1 1 1 1 2 2 2 1 Dynactin subunit p22 GCN5L1 PF06320.13 EAK89594.1 - 0.036 14.2 4.0 0.97 9.6 0.1 2.8 2 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) Snapin_Pallidin PF14712.6 EAK89594.1 - 0.1 13.0 5.0 0.98 9.9 0.1 3.0 3 0 0 3 3 3 0 Snapin/Pallidin Baculo_PEP_C PF04513.12 EAK89594.1 - 0.48 10.5 7.9 0.24 11.4 1.8 2.6 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Elongin_A PF06881.11 EAK89594.1 - 1.1 9.8 4.9 2.6 8.6 0.0 3.2 3 1 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A APG6_N PF17675.1 EAK89594.1 - 3.6 8.1 8.4 3.1 8.3 0.1 3.2 2 2 1 3 3 3 0 Apg6 coiled-coil region NUDIX PF00293.28 EAK89595.1 - 5e-09 36.3 0.0 1.1e-08 35.2 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain DLEU7 PF15760.5 EAK89595.1 - 0.11 12.0 0.2 0.16 11.5 0.2 1.2 1 0 0 1 1 1 0 Leukemia-associated protein 7 Nucleoside_tran PF01733.18 EAK89596.1 - 1.5 8.2 3.8 3.3 7.0 3.8 1.6 1 0 0 1 1 1 0 Nucleoside transporter SNF2_N PF00176.23 EAK89597.1 - 2.7e-50 171.1 0.3 7.7e-50 169.6 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain PHD PF00628.29 EAK89597.1 - 3.5e-19 68.4 68.5 1.4e-09 37.7 5.3 6.5 6 0 0 6 6 6 5 PHD-finger Helicase_C PF00271.31 EAK89597.1 - 1.3e-12 48.0 0.0 4.2e-12 46.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89597.1 - 0.00013 22.0 2.9 0.00037 20.5 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit PHD_2 PF13831.6 EAK89597.1 - 0.00013 21.4 0.8 0.00013 21.4 0.8 6.9 7 0 0 7 7 7 1 PHD-finger Zf_RING PF16744.5 EAK89597.1 - 3.2 7.9 31.2 0.15 12.1 2.5 5.3 4 1 0 4 4 4 0 KIAA1045 RING finger Lge1 PF11488.8 EAK89597.1 - 4.3 7.6 11.8 0.3 11.3 4.8 2.7 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 ELO PF01151.18 EAK89598.1 - 9.8e-68 228.4 25.0 1.3e-67 228.0 25.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ANAPC4_WD40 PF12894.7 EAK89599.1 - 5.3e-08 33.1 0.1 0.51 10.7 0.0 5.0 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EAK89599.1 - 0.029 15.2 1.1 34 5.5 0.0 4.7 6 1 0 6 6 6 0 WD domain, G-beta repeat DNA_pol_delta_4 PF04081.13 EAK89600.1 - 1.7e-07 31.6 0.1 2.5e-07 31.1 0.1 1.4 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 Tho1_MOS11_C PF18592.1 EAK89600.1 - 0.18 11.6 0.0 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Tho1/MOS11 C-terminal domain HAS-barrel PF09378.10 EAK89602.1 - 0.052 13.7 0.9 2.8 8.1 0.1 2.4 1 1 1 2 2 2 0 HAS barrel domain Brix PF04427.18 EAK89603.1 - 1.7e-23 83.8 0.1 2.2e-23 83.4 0.1 1.2 1 0 0 1 1 1 1 Brix domain Sec23_trunk PF04811.15 EAK89603.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain zf-CCHC_2 PF13696.6 EAK89604.1 - 0.018 14.8 1.8 0.018 14.8 1.8 2.9 2 0 0 2 2 2 0 Zinc knuckle LepA_C PF06421.12 EAK89604.1 - 0.043 14.0 0.8 0.096 12.9 0.8 1.5 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus TRAPPC10 PF12584.8 EAK89604.1 - 0.16 11.7 0.7 0.31 10.7 0.0 1.8 2 0 0 2 2 2 0 Trafficking protein particle complex subunit 10, TRAPPC10 zf-CCHC PF00098.23 EAK89604.1 - 0.24 11.5 8.9 0.51 10.5 1.0 3.1 2 0 0 2 2 2 0 Zinc knuckle tRNA-synt_2b PF00587.25 EAK89605.1 - 9.6e-35 120.2 0.0 1.5e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EAK89605.1 - 5.9e-14 52.2 8.7 5.9e-14 52.2 8.7 1.5 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DHHC PF01529.20 EAK89606.1 - 1.3e-27 96.6 15.9 1.3e-27 96.6 15.9 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase DEAD PF00270.29 EAK89607.1 - 3.8e-31 108.2 0.1 9.5e-31 106.9 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89607.1 - 1.3e-23 83.5 1.8 2.1e-23 82.8 0.3 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89607.1 - 8.8e-06 25.8 0.0 8.8e-06 25.8 0.0 2.6 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EAK89607.1 - 0.021 15.1 0.1 0.1 12.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain PrmA PF06325.13 EAK89608.1 - 2.6e-09 36.9 0.1 4.7e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EAK89608.1 - 9e-09 35.9 0.0 1.8e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK89608.1 - 4.1e-08 33.2 0.0 6.8e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK89608.1 - 4.8e-07 30.3 0.0 9.8e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK89608.1 - 2.7e-05 24.0 0.0 4.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EAK89608.1 - 4.1e-05 22.7 0.1 5.6e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 EAK89608.1 - 0.00036 20.5 0.8 0.00075 19.5 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EAK89608.1 - 0.00072 19.1 0.2 0.0012 18.4 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EAK89608.1 - 0.0031 17.3 0.1 0.0049 16.6 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 EAK89608.1 - 0.0047 16.7 0.1 0.0076 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 EAK89608.1 - 0.0061 16.1 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 Histone methylation protein DOT1 PRMT5 PF05185.16 EAK89608.1 - 0.012 15.5 0.4 0.044 13.6 0.1 2.0 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.12 EAK89608.1 - 0.012 16.3 0.0 0.032 15.0 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EAK89608.1 - 0.025 14.2 0.0 0.049 13.3 0.0 1.5 1 1 0 1 1 1 0 Conserved hypothetical protein 95 Rsm22 PF09243.10 EAK89608.1 - 0.041 13.1 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_32 PF13679.6 EAK89608.1 - 0.058 13.4 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EAK89608.1 - 0.19 12.8 0.0 0.33 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CPSF_A PF03178.15 EAK89609.1 - 5.8e-18 65.3 0.1 2.2e-13 50.2 0.0 3.2 4 0 0 4 4 4 2 CPSF A subunit region RIC1 PF07064.13 EAK89610.1 - 1.1e-05 25.0 0.0 2.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 RIC1 ATP-synt_C PF00137.21 EAK89611.1 - 2.9e-30 104.4 18.0 6.4e-16 58.5 4.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C SHMT PF00464.19 EAK89612.1 - 3.4e-74 249.9 0.0 1.8e-73 247.4 0.0 1.8 1 1 0 1 1 1 1 Serine hydroxymethyltransferase RINGv PF12906.7 EAK89613.1 - 6.8e-13 48.5 6.3 1.8e-12 47.2 6.3 1.8 1 0 0 1 1 1 1 RING-variant domain FHA PF00498.26 EAK89613.1 - 6.8e-12 45.6 2.0 6.3e-11 42.5 0.3 3.0 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EAK89613.1 - 2e-07 31.2 0.1 2.6e-06 27.6 0.1 2.4 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Thioredoxin PF00085.20 EAK89613.1 - 0.044 13.8 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin zf-RING_2 PF13639.6 EAK89613.1 - 0.1 12.9 9.4 0.51 10.7 9.6 2.2 1 1 0 1 1 1 0 Ring finger domain FANCL_C PF11793.8 EAK89613.1 - 0.32 11.2 3.3 0.74 10.0 3.3 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain NIF PF03031.18 EAK89614.1 - 1.9e-14 53.7 7.5 1.5e-10 41.1 0.2 3.8 3 1 1 4 4 4 2 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 EAK89614.1 - 2e-05 24.4 0.1 4.1e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain PNK3P PF08645.11 EAK89614.1 - 0.0041 16.8 0.1 0.19 11.4 0.1 2.5 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase BRCT PF00533.26 EAK89614.1 - 0.0056 17.0 0.9 0.024 15.0 0.3 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain TFIID-31kDa PF02291.15 EAK89615.1 - 9.4e-06 25.7 0.9 1.8e-05 24.8 0.9 1.5 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Kazal_1 PF00050.21 EAK89616.1 - 8.7e-09 35.3 3.3 1.6e-08 34.4 3.3 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EAK89616.1 - 1.7e-06 28.0 3.4 3e-06 27.2 3.4 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Smg8_Smg9 PF10220.9 EAK89616.1 - 5.2 5.2 7.6 8.7 4.5 7.6 1.3 1 0 0 1 1 1 0 Smg8_Smg9 Myb_DNA-binding PF00249.31 EAK89617.1 - 0.00011 22.4 0.0 0.00023 21.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Caldesmon PF02029.15 EAK89617.1 - 0.00032 19.6 5.5 0.00032 19.6 5.5 2.9 4 0 0 4 4 4 1 Caldesmon Sporozoite_P67 PF05642.11 EAK89617.1 - 0.00056 18.1 15.7 0.00056 18.1 15.7 5.4 3 2 1 4 4 4 1 Sporozoite P67 surface antigen Trypan_PARP PF05887.11 EAK89617.1 - 0.021 14.8 0.2 0.063 13.3 0.2 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CLN3 PF02487.17 EAK89617.1 - 0.041 12.9 6.5 0.16 10.9 6.5 2.0 1 0 0 1 1 1 0 CLN3 protein Sad1_UNC PF07738.13 EAK89618.1 - 5.8e-09 36.1 3.7 9.1e-06 25.7 0.0 3.1 3 0 0 3 3 3 2 Sad1 / UNC-like C-terminal Neur_chan_memb PF02932.16 EAK89619.1 - 1.6 8.8 4.3 2.4 8.2 4.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SelP_N PF04592.14 EAK89619.1 - 1.8 7.9 21.9 2.9 7.2 21.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region UCH_1 PF13423.6 EAK89620.1 - 1.5e-24 87.2 0.0 5e-24 85.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EAK89620.1 - 1.9e-10 41.6 0.0 3.2e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Exonuclease WD40 PF00400.32 EAK89621.1 - 5.9e-07 30.1 3.1 0.00074 20.3 0.1 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat Proteasom_Rpn13 PF04683.13 EAK89621.1 - 0.08 13.5 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 Proteasome complex subunit Rpn13 ubiquitin receptor Glyco_transf_20 PF00982.21 EAK89622.1 - 3.5e-102 342.5 1.8 1.9e-88 297.2 0.3 2.4 2 0 0 2 2 2 2 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EAK89622.1 - 1.2e-42 145.7 0.0 4.7e-26 91.4 0.0 3.2 2 1 0 2 2 2 2 Trehalose-phosphatase Hydrolase_3 PF08282.12 EAK89622.1 - 0.37 10.5 11.2 5 6.8 0.0 5.2 5 1 1 6 6 6 0 haloacid dehalogenase-like hydrolase U1snRNP70_N PF12220.8 EAK89622.1 - 0.63 10.7 5.6 4.4 8.0 2.4 2.9 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Helicase_C PF00271.31 EAK89623.1 - 1.9e-21 76.5 0.3 1e-17 64.4 0.1 3.1 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 EAK89623.1 - 2.7e-15 56.6 0.2 2.8e-13 50.0 0.0 3.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EAK89623.1 - 4e-11 43.2 0.0 4e-11 43.2 0.0 3.5 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit eIF3_p135 PF12807.7 EAK89624.1 - 7.2e-05 22.9 0.5 0.00053 20.1 0.0 2.6 2 1 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 ANAPC3 PF12895.7 EAK89624.1 - 0.05 13.8 3.6 3 8.1 0.1 3.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Fungal_trans_2 PF11951.8 EAK89625.1 - 0.0066 15.3 0.5 0.0079 15.1 0.5 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gtr1_RagA PF04670.12 EAK89626.1 - 7.8e-52 175.9 0.3 1.1e-51 175.4 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EAK89626.1 - 7e-08 32.1 0.0 1.3e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EAK89626.1 - 0.00011 21.7 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAK89626.1 - 0.00051 20.1 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase KTI12 PF08433.10 EAK89626.1 - 0.042 13.3 0.0 0.068 12.6 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Utp12 PF04003.12 EAK89627.1 - 9.2e-05 22.7 0.4 0.00014 22.1 0.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family DNA_pol_phi PF04931.13 EAK89627.1 - 0.1 10.7 46.1 0.15 10.2 46.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Hid1 PF12722.7 EAK89627.1 - 0.6 8.2 7.8 0.69 8.0 7.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 EAK89627.1 - 5.5 5.2 27.8 9.2 4.4 27.8 1.4 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 EAK89627.1 - 9.9 5.4 33.5 12 5.0 33.5 1.1 1 0 0 1 1 1 0 BUD22 IMCp PF12314.8 EAK89629.1 - 8.5e-19 67.7 58.8 4.2e-18 65.4 26.9 3.6 1 1 2 3 3 3 3 Inner membrane complex protein CBM_20 PF00686.19 EAK89630.1 - 6.7e-21 74.0 2.2 9.4e-21 73.5 2.2 1.2 1 0 0 1 1 1 1 Starch binding domain DUF727 PF05303.12 EAK89631.1 - 0.0053 16.8 0.6 0.07 13.2 0.2 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF727) Use1 PF09753.9 EAK89633.1 - 0.79 9.4 8.1 3.7 7.2 4.9 2.2 2 0 0 2 2 2 0 Membrane fusion protein Use1 AP-5_subunit_s1 PF15001.6 EAK89635.1 - 0.018 15.0 0.1 0.028 14.4 0.1 1.3 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 DUF1878 PF08963.10 EAK89636.1 - 0.015 15.8 1.6 0.024 15.2 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1878) MHC_I PF00129.18 EAK89636.1 - 0.026 14.1 0.5 0.041 13.5 0.5 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 bZIP_1 PF00170.21 EAK89636.1 - 0.061 13.4 7.0 0.21 11.7 2.9 2.4 2 0 0 2 2 2 0 bZIP transcription factor RNB PF00773.19 EAK89637.1 - 4.3e-100 335.2 6.8 4.3e-100 335.2 6.8 2.5 3 0 0 3 3 3 1 RNB domain OB_RNB PF08206.11 EAK89637.1 - 9.4e-05 22.0 0.1 0.0002 21.0 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain EMP24_GP25L PF01105.24 EAK89638.1 - 3.3e-18 66.3 0.2 4.7e-18 65.8 0.2 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD tRNA_int_endo_N PF02778.14 EAK89638.1 - 0.13 12.0 0.1 0.38 10.4 0.1 1.7 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain DUF5104 PF17117.5 EAK89639.1 - 0.039 14.4 6.3 0.81 10.1 0.8 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5104) V-SNARE_C PF12352.8 EAK89639.1 - 0.044 14.1 0.4 0.18 12.1 0.3 2.0 1 1 1 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Vip3A_N PF12495.8 EAK89639.1 - 0.047 13.6 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal PRT_C PF08372.10 EAK89639.1 - 0.059 13.1 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Plk4_PB2 PF18409.1 EAK89639.1 - 0.51 11.0 7.0 0.54 11.0 0.8 2.7 2 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 Fib_alpha PF08702.10 EAK89639.1 - 1.7 8.8 10.6 0.39 10.9 0.7 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EAK89639.1 - 5.8 7.0 7.2 1.4 8.9 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Spc24 PF08286.11 EAK89639.1 - 9.8 6.5 11.3 8.9 6.6 6.4 2.7 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 PsbL PF02419.17 EAK89640.1 - 0.037 14.0 0.5 0.087 12.8 0.5 1.6 1 0 0 1 1 1 0 PsbL protein Strabismus PF06638.11 EAK89640.1 - 0.06 12.0 0.0 0.098 11.3 0.0 1.3 1 1 0 1 1 1 0 Strabismus protein BRCA2 PF00634.18 EAK89641.1 - 1.9e-59 197.0 32.5 1.1e-07 31.4 0.2 8.8 9 0 0 9 9 9 8 BRCA2 repeat BRCA-2_OB1 PF09103.10 EAK89641.1 - 4.9e-05 23.3 0.0 0.00012 22.0 0.0 1.7 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 PAP2 PF01569.21 EAK89642.1 - 2.9e-08 33.6 7.4 1.5e-06 28.0 7.4 2.4 1 1 0 1 1 1 1 PAP2 superfamily TPPII_N PF12583.8 EAK89642.1 - 0.083 13.5 0.5 0.13 12.8 0.5 1.2 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal DUF212 PF02681.14 EAK89642.1 - 0.16 12.1 1.0 1.7 8.8 0.2 2.2 2 0 0 2 2 2 0 Divergent PAP2 family OST3_OST6 PF04756.13 EAK89644.1 - 1.1e-30 107.0 12.8 1.5e-30 106.6 12.8 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF3974 PF13120.6 EAK89644.1 - 5.9 7.0 7.8 0.21 11.7 1.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3974) NADH_dehy_S2_C PF06444.11 EAK89644.1 - 8.9 6.9 12.7 0.2 12.2 0.9 3.3 3 1 0 3 3 3 0 NADH dehydrogenase subunit 2 C-terminus CENP-T_C PF15511.6 EAK89645.1 - 9.5e-09 35.4 0.2 1.1e-08 35.1 0.2 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EAK89645.1 - 0.00018 21.7 0.0 0.00028 21.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EAK89645.1 - 0.00054 20.3 0.4 0.00062 20.1 0.4 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EAK89645.1 - 0.00072 19.7 0.1 0.00098 19.3 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 EAK89645.1 - 0.0043 17.1 0.0 0.0053 16.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 EAK89645.1 - 0.014 15.8 0.2 0.019 15.3 0.2 1.3 1 1 0 1 1 1 0 CENP-S protein Bromo_TP PF07524.13 EAK89645.1 - 0.034 14.1 0.0 0.04 13.9 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EAK89645.1 - 0.12 12.2 0.1 0.15 11.9 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Thr_dehydrat_C PF00585.18 EAK89645.1 - 0.14 12.0 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase PHD PF00628.29 EAK89646.1 - 1.5e-10 40.8 40.9 5.2e-08 32.6 15.2 5.1 3 2 2 5 5 5 2 PHD-finger PHD_2 PF13831.6 EAK89646.1 - 0.0031 17.0 4.7 0.0031 17.0 4.7 5.8 6 1 0 6 6 6 2 PHD-finger zf-C2H2_6 PF13912.6 EAK89646.1 - 0.17 11.9 0.2 0.17 11.9 0.2 6.5 8 0 0 8 8 8 0 C2H2-type zinc finger SRP54 PF00448.22 EAK89647.1 - 7.7e-56 188.8 0.4 1.5e-55 187.9 0.4 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EAK89647.1 - 5.6e-08 33.1 24.8 0.00012 22.2 5.0 2.1 1 1 1 2 2 2 2 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 EAK89647.1 - 2.3e-07 30.9 0.8 1.3e-06 28.5 0.8 2.4 1 1 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EAK89647.1 - 8.8e-07 28.2 0.0 2.1e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 EAK89647.1 - 0.0017 18.4 0.9 0.17 12.0 0.1 2.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EAK89647.1 - 0.0047 16.7 0.0 0.0091 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EAK89647.1 - 0.0083 16.0 0.2 0.9 9.4 0.0 2.9 3 0 0 3 3 3 1 NTPase RsgA_GTPase PF03193.16 EAK89647.1 - 0.022 14.6 0.1 2.6 7.9 0.0 3.0 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EAK89647.1 - 0.098 13.0 0.1 0.46 10.8 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EAK89647.1 - 0.11 12.2 0.3 3.3 7.5 0.0 3.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain AA_permease_2 PF13520.6 EAK89648.1 - 4.8e-09 35.5 38.8 7.4e-09 34.9 38.6 1.3 1 1 0 1 1 1 1 Amino acid permease Pkinase PF00069.25 EAK89651.1 - 6.1e-11 42.2 0.3 0.00048 19.6 0.2 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK89651.1 - 0.018 14.3 0.1 2.9 7.1 0.1 2.5 2 1 0 2 2 2 0 Protein tyrosine kinase YojJ PF10372.9 EAK89652.1 - 4.6 7.4 11.4 4.4 7.5 0.3 3.1 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus PSI_integrin PF17205.3 EAK89654.1 - 0.0017 18.0 1.6 0.0079 15.9 1.6 2.1 1 0 0 1 1 1 1 Integrin plexin domain YkyA PF10368.9 EAK89654.1 - 0.0041 16.8 24.5 0.0041 16.8 24.5 5.4 2 1 4 6 6 6 1 Putative cell-wall binding lipoprotein BLOC1_2 PF10046.9 EAK89654.1 - 0.014 15.7 5.9 0.014 15.7 5.9 6.8 3 1 3 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SAPS PF04499.15 EAK89656.1 - 0.019 13.7 1.2 0.022 13.6 1.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 EAK89656.1 - 0.031 12.5 4.9 0.034 12.4 4.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EAK89656.1 - 0.19 10.0 6.1 0.24 9.7 6.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EAK89656.1 - 0.24 10.1 4.3 0.3 9.8 4.3 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 EAK89656.1 - 0.41 9.0 9.0 0.51 8.6 9.0 1.2 1 0 0 1 1 1 0 Menin NST1 PF13945.6 EAK89656.1 - 0.7 10.0 13.5 1.2 9.2 13.5 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Spt20 PF12090.8 EAK89656.1 - 0.73 9.4 13.3 1 8.9 13.3 1.1 1 0 0 1 1 1 0 Spt20 family CPSF100_C PF13299.6 EAK89656.1 - 0.99 9.6 4.1 1.4 9.1 4.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NPR3 PF03666.13 EAK89656.1 - 1 8.1 6.6 1.3 7.8 6.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 EAK89656.1 - 3.3 6.4 6.2 4.6 5.9 6.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 EAK89656.1 - 3.9 6.6 6.1 0.65 9.2 2.5 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter SelP_N PF04592.14 EAK89658.1 - 0.4 10.0 29.0 0.58 9.5 29.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 EAK89658.1 - 0.93 8.6 12.4 1.3 8.2 12.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TMPIT PF07851.13 EAK89663.1 - 0.18 11.1 1.0 0.24 10.6 1.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein MOLO1 PF17175.4 EAK89664.1 - 6.1e-13 48.9 0.0 2e-12 47.3 0.0 1.7 1 1 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 EAK89664.1 - 0.0018 18.4 0.0 0.0046 17.1 0.0 1.6 1 1 0 1 1 1 1 TPM domain AAA PF00004.29 EAK89665.1 - 7.7e-42 142.8 0.0 1.5e-41 141.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAK89665.1 - 8.8e-12 44.6 0.3 1.9e-11 43.5 0.3 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EAK89665.1 - 8.3e-11 41.7 0.1 1.8e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EAK89665.1 - 1.4e-07 32.1 0.0 9.7e-05 22.8 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EAK89665.1 - 8.6e-07 29.2 0.4 5.6e-06 26.6 0.0 2.5 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAK89665.1 - 9.1e-07 29.0 0.1 1.2e-05 25.3 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EAK89665.1 - 8.2e-06 25.7 0.0 2.1e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EAK89665.1 - 0.00017 21.9 0.1 0.015 15.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EAK89665.1 - 0.00031 20.3 0.1 0.023 14.4 0.0 2.6 3 0 0 3 3 2 1 Proteasomal ATPase OB N-terminal domain AAA_18 PF13238.6 EAK89665.1 - 0.00039 21.0 0.4 0.0036 17.8 0.0 2.7 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EAK89665.1 - 0.0011 18.5 0.0 0.0022 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EAK89665.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EAK89665.1 - 0.0013 18.0 0.0 0.003 16.8 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain Sigma54_activat PF00158.26 EAK89665.1 - 0.0019 18.0 0.0 0.0063 16.2 0.0 1.9 2 1 0 2 2 1 1 Sigma-54 interaction domain RNA_helicase PF00910.22 EAK89665.1 - 0.0024 18.3 0.0 0.0053 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EAK89665.1 - 0.0036 16.7 0.0 0.0075 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EAK89665.1 - 0.0047 16.8 0.0 0.0096 15.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EAK89665.1 - 0.0058 16.4 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EAK89665.1 - 0.0069 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EAK89665.1 - 0.0074 15.5 0.0 0.018 14.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 EAK89665.1 - 0.01 15.7 1.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EAK89665.1 - 0.014 15.5 0.0 0.062 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EAK89665.1 - 0.018 14.5 0.7 0.033 13.7 0.1 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 EAK89665.1 - 0.023 14.7 0.0 0.056 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EAK89665.1 - 0.03 13.7 0.4 0.097 12.0 0.0 2.0 3 0 0 3 3 3 0 KaiC Parvo_NS1 PF01057.17 EAK89665.1 - 0.033 13.3 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EAK89665.1 - 0.035 13.7 0.0 0.084 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EAK89665.1 - 0.036 14.3 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EAK89665.1 - 0.048 12.9 0.0 0.097 11.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EAK89665.1 - 0.12 12.3 0.1 0.51 10.2 0.1 2.1 1 1 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EAK89665.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 EAK89665.1 - 0.3 11.3 1.8 0.64 10.2 1.8 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family ATG16 PF08614.11 EAK89665.1 - 0.37 11.0 4.6 0.6 10.3 4.6 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) cobW PF02492.19 EAK89666.1 - 6.7e-43 146.3 1.2 1e-42 145.7 1.2 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EAK89666.1 - 6.3e-05 23.0 0.4 0.00016 21.6 0.4 2.1 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EAK89666.1 - 0.00043 20.6 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain CobW_C PF07683.14 EAK89666.1 - 0.00094 19.1 0.0 0.0026 17.7 0.0 1.9 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_14 PF13173.6 EAK89666.1 - 0.0017 18.4 0.0 0.0051 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EAK89666.1 - 0.004 17.1 1.2 1.7 8.6 0.6 2.5 2 0 0 2 2 2 2 RsgA GTPase Viral_helicase1 PF01443.18 EAK89666.1 - 0.0061 16.3 0.3 0.018 14.8 0.0 1.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EAK89666.1 - 0.011 16.1 0.0 0.03 14.7 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain ABC_tran PF00005.27 EAK89666.1 - 0.02 15.4 1.8 0.062 13.8 1.5 2.2 1 1 0 1 1 1 0 ABC transporter TsaE PF02367.17 EAK89666.1 - 0.044 13.8 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EAK89666.1 - 0.047 13.0 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EAK89666.1 - 0.05 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EAK89666.1 - 0.052 13.3 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EAK89666.1 - 0.056 14.0 0.3 0.24 12.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EAK89666.1 - 0.083 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EAK89666.1 - 0.1 12.5 1.5 0.88 9.5 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 EAK89666.1 - 0.11 12.8 0.0 0.31 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain OHA PF14418.6 EAK89666.1 - 0.11 12.3 0.3 0.42 10.4 0.0 2.1 2 0 0 2 2 2 0 OST-HTH Associated domain MeaB PF03308.16 EAK89666.1 - 0.21 10.6 0.4 7.1 5.5 0.0 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB UDPG_MGDP_dh_N PF03721.14 EAK89667.1 - 1e-59 201.3 0.1 2e-59 200.3 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EAK89667.1 - 1.3e-29 102.2 0.1 5.5e-29 100.2 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EAK89667.1 - 3.7e-29 101.2 0.0 2e-27 95.7 0.0 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.23 EAK89667.1 - 4.5e-06 26.7 0.0 0.0075 16.3 0.0 2.5 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.20 EAK89667.1 - 0.0013 18.8 0.4 0.12 12.4 0.0 3.6 3 1 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 EAK89667.1 - 0.011 16.0 0.0 0.052 13.7 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EAK89667.1 - 0.013 15.8 0.0 0.24 11.6 0.0 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EAK89667.1 - 0.043 13.1 0.0 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 EAK89667.1 - 0.16 12.6 0.0 3.4 8.3 0.0 2.9 2 2 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Adap_comp_sub PF00928.21 EAK89668.1 - 2.4e-55 187.7 4.7 3.6e-55 187.2 4.7 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EAK89668.1 - 3.8e-05 23.7 4.6 8.1e-05 22.6 4.6 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain EF-hand_8 PF13833.6 EAK89669.1 - 0.0025 17.6 0.1 0.016 15.0 0.1 2.2 1 1 2 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EAK89669.1 - 0.0034 17.2 0.0 0.008 16.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EAK89669.1 - 0.0063 16.9 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 EAK89669.1 - 0.019 15.3 0.0 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain Gar1 PF04410.14 EAK89670.1 - 2.9e-15 56.4 0.1 2.9e-15 56.4 0.1 2.9 3 1 1 4 4 4 1 Gar1/Naf1 RNA binding region ER_lumen_recept PF00810.18 EAK89671.1 - 1.9e-49 168.3 14.0 2.8e-49 167.7 14.0 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EAK89671.1 - 0.029 14.2 1.7 0.029 14.2 1.7 3.8 2 1 2 4 4 4 0 PQ loop repeat CTP_transf_like PF01467.26 EAK89672.1 - 2.1e-32 112.3 0.1 4e-32 111.4 0.1 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like WD40 PF00400.32 EAK89673.1 - 1.1e-12 48.3 0.5 0.0004 21.1 0.0 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat WD40_4 PF16300.5 EAK89673.1 - 2.5e-11 43.3 0.0 5.8e-11 42.1 0.0 1.7 2 0 0 2 2 2 1 Type of WD40 repeat DUF1899 PF08953.11 EAK89673.1 - 8.4e-05 22.4 0.0 0.00033 20.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EAK89673.1 - 0.00071 19.8 0.1 0.018 15.3 0.0 2.6 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain NPV_P10 PF05531.12 EAK89673.1 - 0.0013 19.2 1.4 0.0035 17.8 0.5 2.2 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein KxDL PF10241.9 EAK89673.1 - 0.026 14.8 0.3 0.34 11.2 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein FlaC_arch PF05377.11 EAK89673.1 - 0.17 12.3 1.2 28 5.2 0.2 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Mito_carr PF00153.27 EAK89674.1 - 2.7e-68 225.9 3.8 4.8e-27 93.7 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HALZ PF02183.18 EAK89675.1 - 0.24 11.7 9.1 2.4 8.4 0.9 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper EF-hand_1 PF00036.32 EAK89676.1 - 1.2e-28 96.5 7.5 1.4e-08 33.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAK89676.1 - 2.2e-26 92.1 4.1 1e-14 54.7 1.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK89676.1 - 1.2e-23 80.9 5.8 2e-08 33.5 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EAK89676.1 - 3.2e-17 62.1 6.9 1.1e-09 38.0 0.5 3.4 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EAK89676.1 - 8.2e-15 53.5 7.4 2.3e-06 26.8 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 EAK89676.1 - 2e-11 44.1 0.2 3.5e-06 27.2 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 EAK89676.1 - 3.6e-05 24.0 0.5 0.068 13.5 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EAK89676.1 - 4.6e-05 23.3 2.4 0.078 12.9 0.1 3.0 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 EAK89676.1 - 4.7e-05 23.4 0.1 0.0068 16.4 0.0 2.8 2 1 1 3 3 3 1 Tellurite resistance protein TerB Caleosin PF05042.13 EAK89676.1 - 0.0015 18.5 0.1 0.83 9.6 0.0 2.9 2 1 1 3 3 3 1 Caleosin related protein SUB1_ProdP9 PF18213.1 EAK89676.1 - 0.0034 17.2 0.1 0.0075 16.1 0.1 1.6 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 SPARC_Ca_bdg PF10591.9 EAK89676.1 - 0.01 16.2 0.1 4.1 7.7 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1257 PF06868.11 EAK89676.1 - 0.014 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) Toprim_2 PF13155.6 EAK89676.1 - 0.046 14.1 0.4 0.34 11.4 0.1 2.2 1 1 1 2 2 2 0 Toprim-like EF-hand_11 PF08976.11 EAK89676.1 - 0.057 14.3 0.1 0.91 10.4 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain DUF3008 PF11450.8 EAK89676.1 - 0.062 13.5 1.0 0.12 12.6 0.1 1.9 2 0 0 2 2 1 0 Protein of unknwon function (DUF3008) Nexin_C PF08628.12 EAK89676.1 - 0.074 13.6 0.0 0.21 12.2 0.0 1.8 2 0 0 2 2 2 0 Sorting nexin C terminal DUF591 PF04569.14 EAK89676.1 - 0.1 12.6 0.4 0.21 11.6 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function Skp1 PF01466.19 EAK89676.1 - 0.22 11.6 1.1 8.6 6.6 0.1 2.7 3 0 0 3 3 3 0 Skp1 family, dimerisation domain DNA_primase_lrg PF04104.14 EAK89678.1 - 2.5e-88 295.9 1.3 4.2e-88 295.2 0.1 1.9 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit Chalcone_2 PF16035.5 EAK89678.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Chalcone isomerase like TPT PF03151.16 EAK89679.1 - 4.5e-20 72.2 19.6 5.5e-20 71.9 19.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EAK89679.1 - 9.2e-09 35.6 30.6 5.7e-05 23.3 12.6 2.4 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 EAK89679.1 - 0.096 11.9 19.3 1.4 8.1 19.3 2.3 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport TMEM234 PF10639.9 EAK89679.1 - 0.19 11.8 6.0 2.3 8.3 1.4 2.9 2 0 0 2 2 2 0 Putative transmembrane family 234 WD40 PF00400.32 EAK89680.1 - 4.9e-46 153.8 21.0 2.6e-06 28.0 0.6 12.6 12 1 0 12 12 12 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK89680.1 - 5e-17 62.0 0.4 0.00035 20.8 0.0 7.1 5 2 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EAK89680.1 - 0.00089 18.7 0.1 0.00089 18.7 0.1 3.5 3 1 0 3 3 3 1 WD40-like domain Utp12 PF04003.12 EAK89680.1 - 0.0015 18.8 1.9 0.0039 17.5 1.9 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family ELYS-bb PF16687.5 EAK89680.1 - 0.029 13.0 0.0 4.2 5.9 0.0 3.1 3 1 1 4 4 4 0 beta-propeller of ELYS nucleoporin Ge1_WD40 PF16529.5 EAK89680.1 - 0.055 12.4 5.4 4.3 6.2 0.2 4.4 5 1 1 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-C2H2_2 PF12756.7 EAK89681.1 - 2.9e-26 91.7 6.3 1.7e-23 82.9 1.7 2.9 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EAK89681.1 - 9.8e-07 28.9 1.4 0.0039 17.5 0.0 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EAK89681.1 - 8.1e-05 23.1 2.1 0.036 14.9 0.2 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EAK89681.1 - 0.00026 21.2 8.0 0.12 12.9 0.4 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type Autoind_bind PF03472.15 EAK89681.1 - 0.05 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Autoinducer binding domain zf-C2H2_6 PF13912.6 EAK89681.1 - 0.16 12.0 2.8 0.24 11.4 0.1 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf_C2H2_6 PF18450.1 EAK89681.1 - 0.69 9.7 5.8 1.9 8.3 0.1 2.8 3 0 0 3 3 3 0 Zinc Finger domain zf-met PF12874.7 EAK89681.1 - 0.94 10.0 3.6 19 5.8 0.2 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type SLD5_C PF16922.5 EAK89682.1 - 0.00017 21.7 0.0 0.0003 20.9 0.0 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus DUF1474 PF07342.11 EAK89682.1 - 0.0095 16.5 0.3 0.29 11.7 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1474) ATP-synt_ab PF00006.25 EAK89683.1 - 9.2e-66 221.5 0.0 1.3e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EAK89683.1 - 1.6e-12 47.8 1.3 2.9e-12 46.9 1.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EAK89683.1 - 0.11 12.6 0.4 0.28 11.4 0.4 1.6 1 0 0 1 1 1 0 HAS barrel domain Fe-ADH PF00465.19 EAK89684.1 - 6.5e-59 199.6 0.0 3.6e-58 197.1 0.0 1.8 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EAK89684.1 - 2.8e-08 33.8 0.8 0.00013 21.8 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase PFK PF00365.20 EAK89684.1 - 0.054 12.8 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphofructokinase Fe-ADH PF00465.19 EAK89685.1 - 2e-111 372.4 0.0 2.9e-111 371.8 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Aldedh PF00171.22 EAK89685.1 - 1.1e-18 67.0 0.1 2.3e-17 62.7 0.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Fe-ADH_2 PF13685.6 EAK89685.1 - 4.1e-17 62.7 0.7 1.4e-07 31.5 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase ThiF PF00899.21 EAK89686.1 - 4e-44 150.8 0.0 5.4e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EAK89686.1 - 0.062 13.4 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase eRF1_1 PF03463.15 EAK89687.1 - 1.6e-33 115.4 1.6 2.5e-33 114.8 0.7 1.8 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_3 PF03465.15 EAK89687.1 - 8.9e-21 74.5 0.3 2.2e-19 70.0 0.0 3.1 2 1 1 3 3 3 1 eRF1 domain 3 eRF1_2 PF03464.15 EAK89687.1 - 4e-13 49.8 0.1 7.6e-13 48.9 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 WD40 PF00400.32 EAK89688.1 - 4e-05 24.3 1.5 0.85 10.6 0.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat NAD_kinase PF01513.21 EAK89689.1 - 2e-56 191.4 0.0 3e-56 190.8 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase OGG_N PF07934.12 EAK89690.1 - 1.1e-34 119.2 2.0 2.4e-34 118.0 0.7 2.2 2 1 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EAK89690.1 - 1.9e-07 31.5 0.0 4.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein BTB_2 PF02214.22 EAK89691.1 - 3.7e-13 49.6 1.8 4.6e-13 49.3 0.2 2.0 2 1 0 2 2 2 1 BTB/POZ domain DA1-like PF12315.8 EAK89691.1 - 0.006 16.0 1.1 0.0089 15.4 1.1 1.3 1 0 0 1 1 1 1 Protein DA1 Exo5 PF09810.9 EAK89691.1 - 0.057 12.9 7.9 0.066 12.7 7.9 1.1 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease RCC1_2 PF13540.6 EAK89692.1 - 1.5e-28 97.9 4.0 3e-08 33.3 0.0 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EAK89692.1 - 4.3e-19 68.9 0.8 1.4e-05 25.6 0.0 7.1 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat Phosphodiest PF01663.22 EAK89693.1 - 0.00015 21.5 5.1 0.025 14.2 5.1 2.8 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CSD PF00313.22 EAK89694.1 - 1.3e-24 85.8 0.1 1.9e-24 85.3 0.1 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EAK89694.1 - 1.5e-05 24.6 0.9 1.5e-05 24.6 0.9 2.1 2 1 0 2 2 2 1 Ribonuclease B OB domain API5 PF05918.11 EAK89694.1 - 0.57 8.9 4.0 0.75 8.5 4.0 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF5320 PF17253.2 EAK89694.1 - 0.57 11.3 10.9 0.91 10.6 10.0 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF1633 PF07794.11 EAK89694.1 - 0.6 8.2 3.2 0.66 8.1 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) PfkB PF00294.24 EAK89695.1 - 1.2e-29 103.6 0.0 2.5e-29 102.5 0.0 1.4 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Ring_hydroxyl_A PF00848.19 EAK89695.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) RHD3 PF05879.12 EAK89696.1 - 1.1e-85 288.4 9.7 1.6e-83 281.2 9.7 2.0 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EAK89696.1 - 2e-05 24.0 0.1 5.6e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 EAK89696.1 - 0.00011 22.3 0.0 0.00032 20.7 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ca_hom_mod PF14798.6 EAK89696.1 - 0.0026 16.9 0.3 0.028 13.5 0.1 2.2 2 0 0 2 2 2 1 Calcium homeostasis modulator Dynamin_N PF00350.23 EAK89696.1 - 0.0072 16.4 1.2 0.012 15.6 0.1 2.0 2 0 0 2 2 2 1 Dynamin family Roc PF08477.13 EAK89696.1 - 0.0076 16.5 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EAK89696.1 - 0.019 15.2 1.7 0.032 14.5 0.5 1.9 2 0 0 2 2 2 0 AAA domain zf-RING_2 PF13639.6 EAK89697.1 - 1.2e-09 38.3 6.4 2.1e-09 37.5 6.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EAK89697.1 - 1.3e-08 34.5 6.6 2.5e-08 33.6 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EAK89697.1 - 2.1e-07 31.1 8.4 9.1e-07 29.1 8.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EAK89697.1 - 8.4e-07 28.8 5.7 1.7e-06 27.8 5.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAK89697.1 - 1.8e-06 27.7 4.0 3.5e-06 26.8 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK89697.1 - 2e-05 24.5 2.1 2e-05 24.5 2.1 2.1 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EAK89697.1 - 3.5e-05 23.6 4.6 7e-05 22.6 4.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EAK89697.1 - 0.00058 19.8 5.5 0.002 18.0 5.8 1.8 1 1 1 2 2 2 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EAK89697.1 - 0.00063 19.3 3.2 0.0013 18.3 3.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EAK89697.1 - 0.0017 18.3 1.3 0.0038 17.2 1.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1201 PF06716.11 EAK89697.1 - 0.0032 17.5 1.9 0.0032 17.5 1.9 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1201) zf-RING_11 PF17123.5 EAK89697.1 - 0.0049 16.6 2.4 0.0049 16.6 2.4 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_6 PF14835.6 EAK89697.1 - 0.056 13.3 1.6 0.11 12.4 1.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FANCL_C PF11793.8 EAK89697.1 - 0.082 13.1 3.3 0.87 9.8 3.3 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 EAK89697.1 - 0.17 12.2 5.3 0.32 11.4 5.3 1.5 1 0 0 1 1 1 0 RING-like domain PROCN PF08083.11 EAK89697.1 - 0.19 10.4 1.1 1.6 7.3 0.1 2.2 2 0 0 2 2 2 0 PROCN (NUC071) domain zf-C3HC4_4 PF15227.6 EAK89697.1 - 0.28 11.4 5.6 0.65 10.2 5.6 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EAK89697.1 - 0.62 10.2 4.7 1.5 9.0 4.7 1.7 1 0 0 1 1 1 0 RING-variant domain CTU2 PF10288.9 EAK89697.1 - 2.2 8.5 7.3 0.78 10.0 3.0 2.3 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 FAD_binding_3 PF01494.19 EAK89698.1 - 4e-56 190.8 0.0 4.8e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 EAK89698.1 - 3.2e-05 23.1 0.0 0.00013 21.1 0.0 1.9 1 1 0 1 1 1 1 Squalene epoxidase Staphopain_pro PF14731.6 EAK89698.1 - 0.054 13.5 2.2 0.13 12.2 1.6 1.9 1 1 0 1 1 1 0 Staphopain proregion MKT1_N PF12247.8 EAK89698.1 - 0.078 13.4 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication Pyr_redox_2 PF07992.14 EAK89699.1 - 1.9e-06 27.3 0.0 0.0044 16.3 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EAK89699.1 - 0.0002 21.4 0.0 0.00058 19.9 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EAK89699.1 - 0.0012 19.0 0.0 0.0028 17.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain UPRTase PF14681.6 EAK89700.1 - 4.7e-62 209.1 0.0 6.8e-62 208.6 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EAK89700.1 - 2.1e-47 161.4 0.1 3.1e-47 160.9 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CoaE PF01121.20 EAK89700.1 - 0.00011 21.9 0.1 0.62 9.7 0.0 2.4 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_18 PF13238.6 EAK89700.1 - 0.0062 17.1 0.0 0.019 15.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EAK89700.1 - 0.021 14.6 0.1 0.066 12.9 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase AAA_33 PF13671.6 EAK89700.1 - 0.025 14.7 0.0 0.054 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EAK89700.1 - 0.04 13.2 0.0 0.098 11.9 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 EAK89700.1 - 0.096 13.1 0.0 0.24 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.6 EAK89700.1 - 0.37 11.2 2.5 8 6.9 2.5 2.4 1 1 0 1 1 1 0 AAA domain Ribosomal_L1 PF00687.21 EAK89701.1 - 2.6e-42 144.9 1.6 3.1e-42 144.6 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.8 EAK89701.1 - 0.048 13.7 4.8 0.071 13.2 4.2 1.7 1 1 0 1 1 1 0 Protein of unknown function MetOD2 PF18548.1 EAK89701.1 - 0.082 13.0 2.9 0.36 11.0 0.1 2.6 3 0 0 3 3 3 0 Metanogen output domain 2 COPIIcoated_ERV PF07970.12 EAK89702.1 - 1.3e-44 152.7 1.9 1.9e-44 152.1 1.9 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EAK89702.1 - 3.1e-20 72.3 1.5 4.2e-20 71.9 0.1 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DNA_pol3_delta2 PF13177.6 EAK89703.1 - 5.2e-16 58.9 0.0 1.4e-15 57.5 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EAK89703.1 - 2.2e-13 50.8 0.0 4.4e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EAK89703.1 - 2.4e-12 47.1 0.2 8.3e-12 45.4 0.1 2.0 2 0 0 2 2 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 EAK89703.1 - 1.1e-07 31.9 0.0 1.8e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EAK89703.1 - 2.2e-06 27.5 0.0 3.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EAK89703.1 - 1.5e-05 25.0 0.0 4.4e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK89703.1 - 4.5e-05 23.9 0.1 0.00025 21.5 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EAK89703.1 - 6.9e-05 23.1 0.1 0.0015 18.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EAK89703.1 - 0.00013 21.9 0.1 0.00024 21.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EAK89703.1 - 0.00014 22.1 0.0 0.00041 20.6 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 EAK89703.1 - 0.0002 21.4 0.0 0.00042 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EAK89703.1 - 0.0039 17.5 0.1 0.072 13.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EAK89703.1 - 0.006 16.4 0.1 0.01 15.6 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit TIP49 PF06068.13 EAK89703.1 - 0.0084 15.3 0.0 0.035 13.3 0.0 1.9 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_18 PF13238.6 EAK89703.1 - 0.0096 16.5 0.0 0.02 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EAK89703.1 - 0.0098 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 EAK89703.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EAK89703.1 - 0.015 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 EAK89703.1 - 0.031 13.5 0.0 0.085 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 EAK89703.1 - 0.037 13.8 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EAK89703.1 - 0.052 14.0 0.0 0.15 12.5 0.0 1.8 1 1 0 1 1 1 0 RNA helicase TniB PF05621.11 EAK89703.1 - 0.061 12.7 0.1 0.26 10.7 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 EAK89703.1 - 0.095 12.1 0.0 0.42 10.0 0.0 2.0 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EAK89703.1 - 0.1 12.7 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EAK89703.1 - 0.11 12.5 0.0 1.2 9.1 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit GTP_EFTU PF00009.27 EAK89704.1 - 8.4e-67 224.5 0.1 1.2e-66 223.9 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EAK89704.1 - 3.3e-33 114.0 0.0 9.6e-33 112.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EAK89704.1 - 9.9e-22 76.8 0.0 2.1e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EAK89704.1 - 1.1e-14 54.2 0.0 2.5e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EAK89704.1 - 5.6e-12 45.9 0.1 1.2e-11 44.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EAK89704.1 - 0.00039 20.5 0.0 0.001 19.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EAK89704.1 - 0.014 15.2 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain ANAPC4_WD40 PF12894.7 EAK89705.1 - 1.9e-09 37.7 0.4 0.67 10.3 0.0 6.2 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EAK89705.1 - 3.9e-07 30.6 13.0 0.86 10.6 0.6 8.2 9 0 0 9 9 9 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EAK89705.1 - 0.0028 16.7 0.9 0.52 9.2 0.0 4.1 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Fcf2 PF08698.11 EAK89706.1 - 2.4e-17 63.1 1.6 4e-17 62.4 1.6 1.4 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing Arm PF00514.23 EAK89707.1 - 4.4e-80 261.5 13.8 9.3e-13 47.7 0.0 10.1 10 0 0 10 10 10 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EAK89707.1 - 5.9e-19 68.2 0.1 0.00033 21.1 0.0 6.1 5 1 1 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 EAK89707.1 - 5.6e-17 61.9 0.0 0.00097 19.5 0.0 5.5 2 2 4 6 6 6 5 HEAT repeats Arm_3 PF16186.5 EAK89707.1 - 1.8e-15 56.2 0.5 6e-15 54.5 0.5 1.9 1 0 0 1 1 1 1 Atypical Arm repeat IBB PF01749.20 EAK89707.1 - 8e-15 55.1 4.3 1.1e-13 51.5 3.8 2.4 2 0 0 2 2 2 1 Importin beta binding domain HEAT PF02985.22 EAK89707.1 - 2.1e-14 52.4 0.8 0.024 14.9 0.0 7.0 8 0 0 8 8 7 3 HEAT repeat Cnd1 PF12717.7 EAK89707.1 - 3.9e-05 23.7 0.0 0.057 13.5 0.0 3.0 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EAK89707.1 - 0.0001 21.1 0.0 0.11 11.0 0.1 3.1 2 2 0 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 EAK89707.1 - 0.0041 17.2 0.0 5.9 7.0 0.0 4.1 3 2 2 5 5 5 1 V-ATPase subunit H ParcG PF10274.9 EAK89707.1 - 0.023 14.8 0.1 16 5.6 0.0 3.0 2 1 1 3 3 3 0 Parkin co-regulated protein Mo25 PF08569.11 EAK89707.1 - 0.096 12.0 0.0 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Mo25-like Atx10homo_assoc PF09759.9 EAK89707.1 - 0.13 12.3 0.2 26 4.9 0.0 3.4 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain NUSAP PF16006.5 EAK89707.1 - 2.2 8.0 8.8 3.4 7.3 8.8 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein SBDS PF01172.18 EAK89708.1 - 1.9e-32 111.2 2.0 2.1e-32 111.0 0.2 2.1 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EAK89708.1 - 9.4e-26 90.1 2.9 1.4e-25 89.5 0.9 2.0 2 0 0 2 2 2 1 SBDS protein C-terminal domain zf-met PF12874.7 EAK89708.1 - 0.015 15.7 1.9 0.056 13.9 1.9 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EAK89708.1 - 0.28 11.5 2.2 0.76 10.1 2.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding tRNA_synthFbeta PF17759.1 EAK89709.1 - 2.3e-32 112.2 0.0 3.7e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EAK89709.1 - 5.6e-23 81.0 0.4 3.5e-22 78.4 0.1 2.3 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EAK89709.1 - 3e-18 66.1 0.1 6.7e-18 65.0 0.1 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EAK89709.1 - 8.8e-10 38.7 0.1 9.8e-07 29.0 0.0 2.8 2 0 0 2 2 2 2 tRNA synthetase B5 domain RRM_1 PF00076.22 EAK89710.1 - 3.8e-26 90.7 0.2 2.6e-17 62.4 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EAK89710.1 - 0.012 15.7 0.1 0.85 9.7 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 EAK89710.1 - 0.017 15.1 0.2 0.14 12.2 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EAK89710.1 - 0.023 14.5 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif HEAT_EZ PF13513.6 EAK89711.1 - 1.6e-17 63.6 2.6 9.9e-09 35.5 0.0 6.6 6 1 1 7 7 7 4 HEAT-like repeat HEAT PF02985.22 EAK89711.1 - 2.1e-13 49.2 7.5 0.00087 19.3 0.0 8.4 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EAK89711.1 - 1.3e-07 31.9 0.0 0.0089 16.4 0.0 5.3 4 1 2 6 6 6 3 HEAT repeats Arm PF00514.23 EAK89711.1 - 0.0001 22.2 5.3 0.014 15.4 0.6 4.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DUF3437 PF11919.8 EAK89711.1 - 0.0013 18.6 0.2 0.69 9.9 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) IBN_N PF03810.19 EAK89711.1 - 0.0019 18.1 0.5 0.02 14.8 0.0 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain TAF6_C PF07571.13 EAK89711.1 - 0.087 13.2 0.0 1.2 9.5 0.0 2.9 2 1 1 3 3 3 0 TAF6 C-terminal HEAT repeat domain Adaptin_N PF01602.20 EAK89711.1 - 0.88 8.1 3.7 8.2 4.8 0.0 3.5 4 1 0 4 4 4 0 Adaptin N terminal region tRNA-synt_1g PF09334.11 EAK89712.1 - 8e-97 324.4 1.3 1.2e-54 185.6 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EAK89712.1 - 6.1e-31 107.3 3.9 2.6e-16 59.0 0.2 3.8 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EAK89712.1 - 2.8e-13 49.9 0.0 6.1e-08 32.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EAK89712.1 - 0.00078 18.5 0.0 1.1 8.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) Anticodon_1 PF08264.13 EAK89712.1 - 0.016 15.1 0.1 0.06 13.3 0.1 2.0 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Ribosomal_L34e PF01199.18 EAK89713.1 - 2.3e-38 130.4 5.6 2.3e-38 130.4 5.6 1.6 2 0 0 2 2 2 1 Ribosomal protein L34e SelP_N PF04592.14 EAK89713.1 - 0.095 12.1 2.0 0.22 10.9 0.5 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF3090 PF11290.8 EAK89713.1 - 2.2 8.0 7.5 13 5.5 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3090) PITH PF06201.13 EAK89714.1 - 7.3e-23 81.5 2.0 8.5e-23 81.3 2.0 1.0 1 0 0 1 1 1 1 PITH domain Sad1_UNC PF07738.13 EAK89714.1 - 0.014 15.4 0.2 0.022 14.8 0.2 1.5 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal DUF974 PF06159.13 EAK89716.1 - 3.5e-18 66.3 0.3 5.7e-18 65.6 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF974) SVA PF05326.11 EAK89716.1 - 0.08 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) RTC PF01137.21 EAK89717.1 - 3.1e-38 131.2 0.0 3.7e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EAK89717.1 - 7.7e-19 68.1 0.0 1.5e-18 67.2 0.0 1.5 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Carboxyl_trans PF01039.22 EAK89718.1 - 2.1e-146 488.5 0.0 2.8e-146 488.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EAK89718.1 - 1.3e-47 162.1 1.0 2.9e-47 160.9 1.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ACC_central PF08326.12 EAK89718.1 - 5.8e-36 124.0 11.9 1.8e-17 62.9 3.7 5.4 4 1 0 4 4 4 4 Acetyl-CoA carboxylase, central region Biotin_carb_N PF00289.22 EAK89718.1 - 1.4e-28 99.6 0.0 4.1e-28 98.1 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EAK89718.1 - 1.3e-18 67.1 0.0 5.9e-18 64.9 0.0 2.3 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EAK89718.1 - 2.8e-09 36.7 0.0 6.4e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EAK89718.1 - 4.9e-07 29.5 0.3 1.3e-06 28.1 0.3 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EAK89718.1 - 2.8e-06 27.5 0.5 9.5e-06 25.7 0.5 2.0 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 EAK89718.1 - 0.00011 21.8 0.2 0.00027 20.6 0.2 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EAK89718.1 - 0.015 14.9 0.7 0.038 13.6 0.7 1.7 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EAK89718.1 - 0.12 12.3 0.2 0.49 10.3 0.0 2.1 2 0 0 2 2 2 0 Biotin-lipoyl like HlyD_3 PF13437.6 EAK89718.1 - 0.46 11.2 1.6 54 4.5 0.0 3.4 4 0 0 4 4 3 0 HlyD family secretion protein PRANC PF09372.10 EAK89718.1 - 2.6 8.4 8.7 3.5 8.0 5.8 2.8 2 0 0 2 2 2 0 PRANC domain DnaJ_C PF01556.18 EAK89719.1 - 1.7e-38 132.0 1.4 3.1e-38 131.2 1.4 1.5 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EAK89719.1 - 2.6e-24 85.1 1.2 5.1e-24 84.2 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EAK89719.1 - 7.5e-14 51.8 15.6 1.3e-13 51.1 15.6 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EAK89719.1 - 1.2 9.1 12.8 0.3 11.1 3.4 2.8 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein TRAUB PF08164.12 EAK89720.1 - 7.6e-18 64.8 0.0 1.3e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal EII-GUT PF03608.13 EAK89720.1 - 0.033 14.1 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 PTS system enzyme II sorbitol-specific factor DEAD PF00270.29 EAK89721.1 - 5.3e-36 124.0 0.1 1.1e-35 123.0 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89721.1 - 1.1e-27 96.6 1.9 2.6e-27 95.3 0.3 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89721.1 - 2.2e-05 24.5 0.0 4.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EAK89721.1 - 0.0048 16.3 0.1 0.0097 15.3 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit tRNA-synt_1b PF00579.25 EAK89721.1 - 0.077 12.3 0.0 1.9 7.7 0.0 2.2 1 1 0 2 2 2 0 tRNA synthetases class I (W and Y) ChaC PF04752.12 EAK89721.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 ChaC-like protein MutS_V PF00488.21 EAK89722.1 - 7.8e-75 251.0 0.1 1.4e-74 250.2 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EAK89722.1 - 1.8e-23 83.8 0.6 1.8e-23 83.8 0.6 2.2 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EAK89722.1 - 8.8e-05 22.8 2.7 0.00011 22.5 0.3 2.5 2 0 0 2 2 2 1 MutS domain II DUF2884 PF11101.8 EAK89722.1 - 0.0062 16.1 1.0 0.0095 15.5 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2884) AAA_27 PF13514.6 EAK89722.1 - 0.011 15.4 0.0 0.033 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain NAP PF00956.18 EAK89723.1 - 3.9e-16 59.0 18.0 1.8e-13 50.3 12.2 2.4 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) DUF3836 PF12930.7 EAK89723.1 - 0.033 13.9 0.2 0.056 13.2 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF3836) Clat_adaptor_s PF01217.20 EAK89724.1 - 3.2e-51 173.0 3.0 4.1e-51 172.7 3.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PCI PF01399.27 EAK89725.1 - 3e-17 63.1 3.8 9.4e-17 61.5 0.0 3.2 3 1 0 3 3 3 1 PCI domain Rpn3_C PF08375.11 EAK89725.1 - 3.4e-08 33.8 0.1 3.4e-08 33.8 0.1 3.0 3 0 0 3 3 3 1 Proteasome regulatory subunit C-terminal MNE1 PF13762.6 EAK89725.1 - 0.018 15.1 0.7 0.2 11.7 0.1 2.6 2 0 0 2 2 2 0 Mitochondrial splicing apparatus component TPR_2 PF07719.17 EAK89725.1 - 0.018 15.1 0.4 0.14 12.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat SWIRM PF04433.17 EAK89725.1 - 0.089 13.1 6.2 3 8.3 0.2 3.5 1 1 2 3 3 3 0 SWIRM domain YlbD_coat PF14071.6 EAK89725.1 - 3.3 8.0 8.1 3.5 7.9 1.4 3.3 2 1 1 3 3 3 0 Putative coat protein Ribosomal_S14 PF00253.21 EAK89726.1 - 3.8e-14 52.2 3.5 4.5e-14 51.9 3.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e EF-hand_1 PF00036.32 EAK89727.1 - 4e-20 69.8 5.0 1.1e-05 24.6 1.6 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EAK89727.1 - 4.2e-18 63.7 3.2 1.6e-07 30.7 0.1 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EAK89727.1 - 8.4e-16 58.2 4.8 1.1e-07 32.1 0.5 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EAK89727.1 - 2e-14 53.1 6.3 9e-07 28.6 0.4 4.5 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 EAK89727.1 - 4.2e-12 45.0 2.4 8.7e-05 21.8 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 EAK89727.1 - 1.6e-07 31.6 0.9 0.17 12.2 0.0 3.9 3 1 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 EAK89727.1 - 0.017 15.1 5.0 0.62 10.0 0.5 3.6 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand PEPCK_ATP PF01293.20 EAK89727.1 - 0.084 11.5 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase Caleosin PF05042.13 EAK89727.1 - 0.1 12.5 0.8 7.6 6.4 0.0 2.4 2 0 0 2 2 2 0 Caleosin related protein RRM_1 PF00076.22 EAK89728.1 - 1.8e-09 37.3 0.3 4.2e-09 36.1 0.3 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CotJB PF12652.7 EAK89730.1 - 9.3 6.6 10.2 13 6.1 2.6 3.6 2 0 0 2 2 2 0 CotJB protein Methyltransf_23 PF13489.6 EAK89731.1 - 1.9e-12 47.3 0.0 2.6e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK89731.1 - 9.3e-07 29.5 0.0 3.3e-06 27.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAK89731.1 - 9.2e-05 23.1 0.0 0.018 15.7 0.0 2.5 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK89731.1 - 0.0063 17.1 0.0 0.084 13.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EAK89731.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Kri1_C PF12936.7 EAK89732.1 - 1.3e-24 86.1 1.4 1.3e-24 86.1 1.4 6.2 6 1 0 6 6 6 1 KRI1-like family C-terminal Kri1 PF05178.12 EAK89732.1 - 6.6e-15 55.5 16.0 6.6e-15 55.5 16.0 4.9 4 2 0 4 4 4 1 KRI1-like family FYVE PF01363.21 EAK89732.1 - 0.026 14.7 2.8 0.067 13.3 2.8 1.6 1 0 0 1 1 1 0 FYVE zinc finger ZZ PF00569.17 EAK89732.1 - 0.062 13.1 9.7 0.18 11.6 9.5 1.8 2 0 0 2 2 2 0 Zinc finger, ZZ type Ribosomal_S8 PF00410.19 EAK89733.1 - 3.5e-20 72.2 0.0 5.5e-20 71.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 ACPS PF01648.20 EAK89734.1 - 4.7e-15 55.7 0.0 1e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily DnaJ PF00226.31 EAK89735.1 - 4.7e-19 68.3 4.2 1.6e-18 66.5 4.2 2.0 1 0 0 1 1 1 1 DnaJ domain Consortin_C PF15281.6 EAK89735.1 - 3.2 7.8 7.2 4.3 7.4 1.6 2.8 2 0 0 2 2 2 0 Consortin C-terminus RRM_1 PF00076.22 EAK89736.1 - 1.8e-10 40.5 1.0 3.9e-05 23.4 0.1 3.9 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK89736.1 - 0.00022 21.3 0.0 0.00042 20.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif zf-CCCH PF00642.24 EAK89737.1 - 2e-08 33.9 15.6 1.8e-05 24.5 2.0 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EAK89737.1 - 6.3e-05 22.7 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EAK89737.1 - 0.0001 22.9 3.3 0.15 12.8 0.5 2.8 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EAK89737.1 - 0.32 11.1 19.3 0.1 12.7 2.5 2.7 2 0 0 2 2 2 0 Zinc finger domain PseudoU_synth_1 PF01416.20 EAK89738.1 - 1e-30 106.4 0.0 1.6e-28 99.3 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 EAK89738.1 - 0.04 13.8 0.0 0.089 12.6 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) KH_10 PF17905.1 EAK89738.1 - 0.12 12.8 0.0 0.36 11.3 0.0 1.8 2 0 0 2 2 2 0 GLD-3 KH domain 5 HhH-GPD PF00730.25 EAK89739.1 - 1.1e-15 58.0 0.2 5.9e-15 55.6 0.1 1.9 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein SBP_bac_5 PF00496.22 EAK89739.1 - 0.032 13.2 0.0 0.058 12.3 0.0 1.4 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 5 Middle UQ_con PF00179.26 EAK89740.1 - 5e-15 55.4 0.0 9.9e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EMC3_TMCO1 PF01956.16 EAK89741.1 - 4.7e-24 85.0 0.0 2.4e-23 82.7 0.0 1.8 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Adipogenin PF15202.6 EAK89741.1 - 1.3 9.1 4.9 5.3 7.1 0.0 3.0 3 0 0 3 3 3 0 Adipogenin DUP PF00674.18 EAK89742.1 - 0.23 11.6 4.6 8.5 6.6 0.1 3.1 2 1 1 3 3 3 0 DUP family COPI_assoc PF08507.10 EAK89743.1 - 1.9e-11 44.1 17.9 2.2e-11 43.9 17.9 1.0 1 0 0 1 1 1 1 COPI associated protein Fip1 PF05182.13 EAK89745.1 - 1.2e-08 34.3 0.1 2.3e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 Fip1 motif MatB PF16449.5 EAK89745.1 - 0.26 11.1 2.0 0.22 11.3 0.2 1.7 2 0 0 2 2 2 0 Fimbrillin MatB RRM_1 PF00076.22 EAK89746.1 - 8.7e-17 60.7 0.0 1.4e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_VP91_N PF08475.10 EAK89747.1 - 0.041 13.6 6.7 0.086 12.5 6.7 1.5 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal DUF2615 PF11027.8 EAK89747.1 - 0.11 12.6 0.3 7.9 6.7 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) CdiI_N PF18228.1 EAK89748.1 - 0.046 13.6 0.1 0.2 11.5 0.1 1.9 1 1 1 2 2 2 0 CdiI N-terminal domain DUF2418 PF10332.9 EAK89748.1 - 0.049 14.1 0.1 0.079 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) PP2C PF00481.21 EAK89749.1 - 2.1e-15 57.1 0.0 1.1e-11 44.9 0.0 2.5 1 1 0 1 1 1 1 Protein phosphatase 2C PH_TFIIH PF08567.11 EAK89750.1 - 0.0062 16.8 0.2 0.02 15.2 0.0 2.0 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Rsd_AlgQ PF04353.13 EAK89750.1 - 0.013 15.5 0.4 0.37 10.7 0.0 2.3 2 0 0 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Zip PF02535.22 EAK89753.1 - 5.7e-40 137.5 9.4 1.5e-39 136.2 9.4 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter SLC12 PF03522.15 EAK89753.1 - 0.29 10.1 8.1 0.4 9.6 8.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RuvC_III PF18541.1 EAK89753.1 - 3.4 7.6 12.7 0.2 11.6 6.4 2.0 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 Menin PF05053.13 EAK89753.1 - 8.4 4.6 12.1 12 4.1 12.1 1.2 1 0 0 1 1 1 0 Menin Synaptobrevin PF00957.21 EAK89754.1 - 4.9e-15 55.1 0.6 8e-15 54.4 0.6 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EAK89754.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain PDEase_I PF00233.19 EAK89755.1 - 1.4e-71 241.0 8.1 1.4e-71 241.0 8.1 4.2 4 1 0 4 4 4 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EAK89755.1 - 0.076 13.2 0.0 0.076 13.2 0.0 2.2 2 0 0 2 2 2 0 HD domain Caldesmon PF02029.15 EAK89755.1 - 2.2 6.9 32.8 0.0067 15.3 22.4 2.0 2 0 0 2 2 2 0 Caldesmon Pkinase PF00069.25 EAK89756.1 - 2.8e-77 259.6 0.0 2.8e-77 259.6 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK89756.1 - 1.1e-38 133.0 0.0 2e-38 132.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EAK89756.1 - 0.0071 15.7 0.1 0.014 14.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAK89756.1 - 0.29 11.0 0.0 0.48 10.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AP-5_subunit_s1 PF15001.6 EAK89757.1 - 1.4 8.9 6.1 4.9 7.1 6.3 1.7 1 1 0 1 1 1 0 AP-5 complex subunit sigma-1 Pkinase PF00069.25 EAK89758.1 - 2.6e-07 30.3 2.7 2.6e-07 30.3 2.7 1.7 2 0 0 2 2 2 1 Protein kinase domain RWD PF05773.22 EAK89758.1 - 0.00074 19.8 1.7 0.0059 16.9 1.7 2.7 1 1 0 1 1 1 1 RWD domain Imm30 PF15565.6 EAK89758.1 - 0.32 11.1 7.5 0.069 13.2 2.0 2.8 2 0 0 2 2 2 0 Immunity protein 30 AAA PF00004.29 EAK89759.1 - 3.3e-30 105.2 0.0 6.2e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EAK89759.1 - 0.00038 21.0 0.0 0.0012 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EAK89759.1 - 0.0015 19.0 0.0 0.0068 16.8 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EAK89759.1 - 0.0017 18.1 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EAK89759.1 - 0.0039 17.1 0.0 0.013 15.4 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_5 PF07728.14 EAK89759.1 - 0.0041 17.1 0.4 0.035 14.1 0.1 2.7 2 2 1 3 3 3 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EAK89759.1 - 0.0077 16.6 0.1 0.09 13.2 0.0 2.8 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 EAK89759.1 - 0.0085 15.3 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EAK89759.1 - 0.01 15.1 0.6 0.017 14.4 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_28 PF13521.6 EAK89759.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EAK89759.1 - 0.013 14.8 0.6 4.6 6.5 0.1 2.6 1 1 1 2 2 2 0 KaiC Mg_chelatase PF01078.21 EAK89759.1 - 0.015 14.7 0.2 0.15 11.4 0.0 2.5 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EAK89759.1 - 0.021 14.6 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 EAK89759.1 - 0.033 13.5 0.0 0.093 12.0 0.0 1.7 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EAK89759.1 - 0.035 14.4 0.6 0.18 12.1 0.1 2.4 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EAK89759.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CPT PF07931.12 EAK89759.1 - 0.096 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 EAK89759.1 - 0.096 12.0 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EAK89759.1 - 0.15 12.4 0.1 0.49 10.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EAK89759.1 - 0.19 11.9 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Usher PF00577.20 EAK89759.1 - 5.4 5.8 12.3 9.7 4.9 12.3 1.3 1 0 0 1 1 1 0 Outer membrane usher protein Beta-Casp PF10996.8 EAK89760.1 - 4.6e-17 62.3 0.2 2.7e-16 59.8 0.0 2.5 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EAK89760.1 - 2e-10 40.5 0.0 4.1e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Pex14_N PF04695.13 EAK89760.1 - 0.16 12.6 2.9 0.41 11.3 2.9 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SR-25 PF10500.9 EAK89760.1 - 6.9 6.2 29.1 0.39 10.3 23.0 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Mic1 PF07035.12 EAK89761.1 - 0.00028 20.6 14.7 0.031 14.0 4.0 3.1 3 1 0 4 4 4 2 Colon cancer-associated protein Mic1-like Asp PF00026.23 EAK89762.1 - 4.6e-50 170.8 0.0 3e-37 128.7 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EAK89762.1 - 1.6e-09 38.3 0.1 1.1e-06 29.0 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EAK89762.1 - 0.11 12.2 0.0 2.4 7.9 0.0 2.2 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal PPV_E1_N PF00524.18 EAK89762.1 - 0.36 11.2 5.7 0.9 10.0 5.7 1.6 1 0 0 1 1 1 0 E1 Protein, N terminal domain DUF2457 PF10446.9 EAK89762.1 - 5.9 5.9 13.6 8.4 5.4 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Peptidase_C11 PF03415.14 EAK89763.1 - 2.2e-23 83.3 0.6 2.2e-23 83.3 0.6 2.9 2 1 0 2 2 2 1 Clostripain family EGF_3 PF12947.7 EAK89763.1 - 1.6e-12 47.4 29.5 1.7e-08 34.5 2.8 5.0 4 0 0 4 4 4 2 EGF domain EGF_CA PF07645.15 EAK89763.1 - 2e-09 37.5 19.9 1.4e-06 28.4 2.9 6.1 6 0 0 6 6 6 2 Calcium-binding EGF domain cEGF PF12662.7 EAK89763.1 - 1e-07 31.7 28.1 0.0056 16.6 0.8 5.1 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF PF00008.27 EAK89763.1 - 6.4e-06 26.4 28.5 0.00034 20.8 2.8 4.7 4 0 0 4 4 4 2 EGF-like domain hEGF PF12661.7 EAK89763.1 - 3.6e-05 24.2 23.3 0.0028 18.2 2.0 4.4 4 0 0 4 4 4 2 Human growth factor-like EGF FXa_inhibition PF14670.6 EAK89763.1 - 0.0013 18.9 31.9 0.017 15.4 6.1 4.9 5 0 0 5 5 5 2 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 EAK89763.1 - 0.0018 18.3 2.2 0.0018 18.3 2.2 4.1 4 0 0 4 4 4 2 MSP1 EGF domain 1 Halogen_Hydrol PF10112.9 EAK89763.1 - 0.056 13.5 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein MpPF26 PF07666.11 EAK89763.1 - 0.071 13.2 5.9 0.24 11.5 5.9 1.9 1 0 0 1 1 1 0 M penetrans paralogue family 26 DUF4064 PF13273.6 EAK89763.1 - 0.073 13.4 2.1 0.18 12.1 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) C2 PF00168.30 EAK89764.1 - 8.3e-06 26.0 0.1 5.7e-05 23.3 0.1 2.4 1 1 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EAK89764.1 - 4.3e-05 23.1 0.0 9.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 CEP76 C2 domain Cnd1 PF12717.7 EAK89766.1 - 2.9e-11 43.7 0.1 2.9e-11 43.7 0.1 6.8 8 2 2 10 10 10 2 non-SMC mitotic condensation complex subunit 1 RTTN_N PF14726.6 EAK89766.1 - 0.043 14.6 1.1 7.2 7.5 0.1 3.7 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning BUD22 PF09073.10 EAK89766.1 - 2.1 7.6 22.8 2 7.7 7.4 2.3 2 0 0 2 2 2 0 BUD22 Folliculin PF11704.8 EAK89766.1 - 4.1 7.3 7.7 0.61 9.9 1.4 2.9 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport Rhomboid PF01694.22 EAK89768.1 - 8.4e-27 94.0 15.2 8.4e-27 94.0 15.2 1.9 3 0 0 3 3 3 1 Rhomboid family Sdh_cyt PF01127.22 EAK89768.1 - 0.79 9.8 6.8 9 6.4 1.3 2.8 3 0 0 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DEC-1_N PF04625.13 EAK89768.1 - 1.1 8.2 6.4 3.1 6.7 6.4 1.7 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ribonuc_red_sm PF00268.21 EAK89769.1 - 1e-104 350.0 2.4 1.5e-104 349.4 2.4 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain TryThrA_C PF12319.8 EAK89769.1 - 0.011 15.3 6.7 0.011 15.3 6.7 1.9 2 0 0 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal RTT107_BRCT_5 PF16770.5 EAK89770.1 - 1.1e-07 31.7 0.1 2.5e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EAK89770.1 - 0.00081 19.7 2.0 0.13 12.6 0.0 3.3 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain FHA PF00498.26 EAK89770.1 - 0.0031 17.8 0.2 0.014 15.8 0.0 2.2 2 0 0 2 2 2 1 FHA domain Lzipper-MIP1 PF14389.6 EAK89771.1 - 0.048 14.0 6.2 0.13 12.6 6.2 1.7 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF5320 PF17253.2 EAK89771.1 - 0.91 10.6 3.0 19 6.4 0.3 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5320) Csm1_N PF18504.1 EAK89771.1 - 1.2 9.5 8.3 0.54 10.6 1.1 2.8 1 1 1 2 2 2 0 Csm1 N-terminal domain FAM76 PF16046.5 EAK89771.1 - 2 7.7 10.3 2.5 7.4 10.3 1.1 1 0 0 1 1 1 0 FAM76 protein PH PF00169.29 EAK89772.1 - 1.1e-08 35.5 0.4 6.6e-06 26.6 0.0 3.8 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 EAK89772.1 - 0.00037 20.7 0.0 0.0015 18.8 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EAK89772.1 - 0.00041 20.6 0.0 0.019 15.3 0.0 3.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EAK89772.1 - 0.072 13.2 0.0 0.28 11.3 0.0 2.0 1 0 0 1 1 1 0 PH domain Peptidase_A22B PF04258.13 EAK89773.1 - 1e-77 261.4 14.3 1.6e-77 260.8 14.3 1.2 1 0 0 1 1 1 1 Signal peptide peptidase Pex24p PF06398.11 EAK89773.1 - 0.27 10.2 0.0 0.27 10.2 0.0 2.5 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin Kei1 PF08552.11 EAK89773.1 - 6.3 6.6 12.8 1.4 8.8 0.1 2.8 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 DUF410 PF04190.13 EAK89775.1 - 3.3e-35 122.1 5.7 4.2e-35 121.8 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) hDGE_amylase PF14701.6 EAK89776.1 - 5.8e-122 407.9 8.3 5.8e-122 407.9 8.3 2.5 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EAK89776.1 - 4.8e-104 348.3 0.1 8.9e-104 347.5 0.1 1.4 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EAK89776.1 - 3.4e-70 236.6 0.2 3.4e-70 236.6 0.2 2.6 3 0 0 3 3 3 1 Central domain of human glycogen debranching enzyme AMPK1_CBM PF16561.5 EAK89776.1 - 7.6e-16 58.1 5.8 1.7e-09 37.8 0.2 3.5 3 1 1 4 4 4 2 Glycogen recognition site of AMP-activated protein kinase Shugoshin_C PF07557.11 EAK89777.1 - 0.0014 18.4 0.6 0.0024 17.6 0.6 1.4 1 0 0 1 1 1 1 Shugoshin C terminus PH_12 PF16457.5 EAK89777.1 - 1 9.9 6.4 0.37 11.3 2.6 2.0 1 1 1 2 2 2 0 Pleckstrin homology domain Sec20 PF03908.13 EAK89778.1 - 1.6e-10 40.7 2.7 2.3e-10 40.3 2.7 1.2 1 0 0 1 1 1 1 Sec20 DUF4407 PF14362.6 EAK89778.1 - 0.04 13.3 0.3 0.052 12.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 EAK89778.1 - 0.091 12.8 4.0 0.12 12.4 4.0 1.1 1 0 0 1 1 1 0 Laminin Domain II Fib_alpha PF08702.10 EAK89778.1 - 0.39 10.9 4.3 0.49 10.6 4.3 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Peptidase_C78 PF07910.13 EAK89779.1 - 2.8e-45 154.4 0.7 5.4e-45 153.5 0.7 1.5 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 EAK89779.1 - 0.00035 20.1 0.0 0.0009 18.7 0.0 1.7 1 1 0 1 1 1 1 Peptidase family C54 RrnaAD PF00398.20 EAK89780.1 - 1e-53 182.1 0.0 1.4e-53 181.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EAK89780.1 - 4.3e-10 40.2 0.0 1e-09 39.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK89780.1 - 6e-09 35.9 0.0 2.1e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK89780.1 - 1.5e-08 35.2 0.0 7e-08 33.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK89780.1 - 9.1e-07 29.5 0.0 3.2e-06 27.8 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EAK89780.1 - 0.00018 21.0 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EAK89780.1 - 0.00053 19.9 0.0 0.0009 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EAK89780.1 - 0.0021 17.6 0.0 0.0048 16.4 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase PrmA PF06325.13 EAK89780.1 - 0.0049 16.3 0.0 0.0077 15.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EAK89780.1 - 0.0082 15.9 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 EAK89780.1 - 0.034 13.2 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_32 PF13679.6 EAK89780.1 - 0.083 12.9 0.0 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EAK89780.1 - 0.088 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Pescadillo_N PF06732.11 EAK89781.1 - 5.6e-100 334.4 1.6 5.6e-100 334.4 1.6 2.1 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EAK89781.1 - 1.4e-06 28.6 0.0 3.9e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EAK89781.1 - 1.9e-05 24.9 0.1 5.6e-05 23.4 0.1 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EAK89781.1 - 0.12 12.7 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain CRAL_TRIO PF00650.20 EAK89782.1 - 6.9e-29 100.6 0.0 1.5e-28 99.6 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EAK89782.1 - 3.3e-06 27.3 0.0 9.5e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EAK89782.1 - 0.00065 19.8 0.5 0.0015 18.6 0.5 1.8 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain SET PF00856.28 EAK89783.1 - 2.2e-07 31.4 0.2 7.3e-07 29.7 0.2 1.9 1 1 0 1 1 1 1 SET domain RRM_1 PF00076.22 EAK89784.1 - 6.6e-18 64.3 0.1 1.2e-17 63.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 EAK89784.1 - 9.8e-12 45.4 2.4 2e-11 44.4 2.4 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PHM7_cyt PF14703.6 EAK89784.1 - 0.0054 17.0 0.3 0.0091 16.2 0.3 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter OB_RNB PF08206.11 EAK89784.1 - 0.11 12.2 0.3 0.35 10.6 0.3 1.9 1 1 0 1 1 1 0 Ribonuclease B OB domain BRAP2 PF07576.12 EAK89784.1 - 0.14 12.4 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 BRCA1-associated protein 2 DUF2852 PF11014.8 EAK89784.1 - 0.21 11.8 2.0 0.38 10.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) IZUMO PF15005.6 EAK89784.1 - 0.27 11.8 0.3 0.54 10.8 0.1 1.5 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated CDC27 PF09507.10 EAK89785.1 - 2.8 7.2 46.7 4.1 6.7 46.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PP2C PF00481.21 EAK89786.1 - 3.4e-13 49.8 0.2 5.6e-05 22.9 0.0 3.4 3 0 0 3 3 3 3 Protein phosphatase 2C PP2C_2 PF13672.6 EAK89786.1 - 0.004 16.8 0.0 0.12 12.0 0.0 2.5 3 0 0 3 3 3 1 Protein phosphatase 2C IF4E PF01652.18 EAK89787.1 - 3.7e-32 111.3 0.6 5.9e-32 110.7 0.6 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Rpr2 PF04032.16 EAK89788.1 - 3e-17 62.7 1.7 4.3e-17 62.2 1.7 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain GidB PF02527.15 EAK89789.1 - 0.048 13.0 0.3 0.15 11.4 0.3 1.8 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DUF2973 PF11189.8 EAK89789.1 - 0.11 12.7 0.3 26 5.0 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) NifU_N PF01592.16 EAK89790.1 - 8.6e-47 158.5 0.1 9.8e-47 158.3 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain DUF1077 PF06417.12 EAK89792.1 - 1.5e-32 112.0 0.3 2.1e-32 111.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Rtt102p PF09510.10 EAK89792.1 - 0.028 14.6 1.2 0.028 14.6 1.2 1.9 1 1 1 2 2 2 0 Rtt102p-like transcription regulator protein GP40 PF11025.8 EAK89793.1 - 2.7e-114 378.5 3.8 2.7e-114 378.5 3.8 2.7 2 1 1 3 3 3 1 Glycoprotein GP40 of Cryptosporidium Asp-B-Hydro_N PF05279.11 EAK89794.1 - 6.9 6.7 33.7 13 5.8 33.7 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Nop PF01798.18 EAK89794.1 - 7.8 5.9 12.0 2.7 7.4 8.8 2.0 1 1 2 3 3 3 0 snoRNA binding domain, fibrillarin AP2 PF00847.20 EAK89798.1 - 9.8e-05 22.5 2.2 9.8e-05 22.5 2.2 2.2 2 0 0 2 2 2 1 AP2 domain ADAM_spacer1 PF05986.14 EAK89801.1 - 0.076 13.1 0.5 0.15 12.1 0.5 1.5 1 0 0 1 1 1 0 ADAM-TS Spacer 1 NOD2_WH PF17779.1 EAK89802.1 - 9.4 6.7 8.0 4.1 7.8 0.1 3.7 4 0 0 4 4 4 0 NOD2 winged helix domain Methyltransf_PK PF05891.12 EAK89803.1 - 1.1e-42 146.0 0.0 1.3e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EAK89803.1 - 2.6e-07 31.3 0.0 7e-07 29.9 0.0 1.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK89803.1 - 1.5e-06 28.7 0.0 3.7e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.11 EAK89803.1 - 0.0066 16.1 0.0 0.0089 15.7 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_12 PF08242.12 EAK89803.1 - 0.11 13.3 0.0 0.46 11.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 EAK89803.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EAK89803.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CLP1_P PF16575.5 EAK89805.1 - 3.4e-20 72.7 0.0 5.4e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 EAK89805.1 - 0.0029 17.7 0.4 0.0098 15.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EAK89805.1 - 0.026 15.0 0.0 0.06 13.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EAK89805.1 - 0.035 14.5 0.0 0.094 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EAK89805.1 - 0.043 13.7 0.4 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EAK89805.1 - 0.045 14.3 0.0 0.091 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EAK89805.1 - 0.046 13.4 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DsrD PF08679.11 EAK89805.1 - 0.089 13.1 0.2 0.31 11.3 0.2 1.9 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) PduV-EutP PF10662.9 EAK89805.1 - 0.091 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EAK89805.1 - 0.094 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein SRP54 PF00448.22 EAK89805.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Iron_traffic PF04362.14 EAK89806.1 - 0.087 12.5 0.2 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking EIF4E-T PF10477.9 EAK89809.1 - 2.5 6.8 4.6 0.53 9.0 0.9 1.6 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E zf-RING_2 PF13639.6 EAK89810.1 - 7.1e-13 48.7 9.8 1.6e-12 47.6 9.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EAK89810.1 - 3e-09 36.4 7.1 8.6e-09 35.0 7.1 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EAK89810.1 - 1.2e-07 31.9 10.2 4.6e-07 30.0 10.2 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EAK89810.1 - 4e-07 29.8 10.8 9.2e-07 28.6 10.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK89810.1 - 3.7e-06 26.7 9.2 6.8e-06 25.8 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK89810.1 - 0.00013 21.9 7.9 0.00028 20.8 7.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EAK89810.1 - 0.00014 21.7 7.7 0.00026 20.8 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EAK89810.1 - 0.0002 20.9 7.2 0.00043 19.8 7.2 1.6 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EAK89810.1 - 0.0046 17.0 2.7 0.0083 16.2 2.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EAK89810.1 - 0.0046 16.9 5.5 0.0055 16.7 3.9 2.0 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EAK89810.1 - 0.0059 16.4 10.6 0.034 14.0 10.1 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EAK89810.1 - 0.036 14.2 5.0 0.063 13.4 5.0 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3H2C3 PF17122.5 EAK89810.1 - 0.12 12.4 8.1 0.31 11.1 7.7 2.0 1 1 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 EAK89810.1 - 1.3 9.0 8.4 1.1 9.2 3.7 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 EAK89810.1 - 1.9 8.7 9.6 39 4.5 9.6 2.5 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EAK89810.1 - 5 7.3 11.1 5.2 7.3 9.6 1.8 2 0 0 2 2 1 0 RING-variant domain zf-LITAF-like PF10601.9 EAK89810.1 - 9.4 6.6 11.5 2.4 8.5 0.7 2.3 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain PAN_2 PF08276.11 EAK89811.1 - 0.0094 16.1 0.1 0.0094 16.1 0.1 4.1 4 1 1 5 5 5 1 PAN-like domain PAN_1 PF00024.26 EAK89811.1 - 0.065 13.2 15.5 2.5 8.1 0.0 3.3 3 1 0 3 3 3 0 PAN domain PAN_4 PF14295.6 EAK89811.1 - 0.21 11.6 0.1 0.21 11.6 0.1 3.7 3 1 0 3 3 3 0 PAN domain V-ATPase_H_C PF11698.8 EAK89812.1 - 0.053 13.6 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 V-ATPase subunit H FmiP_Thoc5 PF09766.9 EAK89814.1 - 0.0012 18.2 8.0 0.31 10.3 7.4 2.2 2 0 0 2 2 2 2 Fms-interacting protein/Thoc5 T3SchapCesA PF11439.8 EAK89814.1 - 1.2 9.3 5.0 0.38 10.9 0.9 2.2 2 0 0 2 2 2 0 Type III secretion system filament chaperone CesA YabA PF06156.13 EAK89814.1 - 1.4 9.6 6.4 6.1 7.5 3.2 2.8 2 1 0 2 2 2 0 Initiation control protein YabA bZIP_1 PF00170.21 EAK89814.1 - 7.1 6.8 7.7 5.7 7.1 5.1 2.2 2 0 0 2 2 2 0 bZIP transcription factor START PF01852.19 EAK89815.1 - 6.4e-09 35.5 0.0 1.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 START domain OCRE PF17780.1 EAK89815.1 - 0.11 12.6 0.4 0.33 11.0 0.4 1.9 1 0 0 1 1 1 0 OCRE domain Hus1 PF04005.12 EAK89817.1 - 1.6e-14 53.8 7.0 2.5e-14 53.1 7.0 1.3 1 1 0 1 1 1 1 Hus1-like protein E2F_TDP PF02319.20 EAK89819.1 - 5.7e-14 51.9 0.0 1.2e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain SET PF00856.28 EAK89820.1 - 1.1e-07 32.4 0.1 1.1e-07 32.4 0.1 3.7 3 2 0 3 3 3 1 SET domain Pik1 PF11522.8 EAK89820.1 - 0.0036 17.2 0.3 0.014 15.3 0.3 2.2 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 CooC_C PF15976.5 EAK89820.1 - 0.0069 16.4 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 CS1-pili formation C-terminal VWA_N2 PF16164.5 EAK89820.1 - 0.25 11.5 8.0 0.87 9.8 8.0 1.8 1 0 0 1 1 1 0 VWA N-terminal Zf_RING PF16744.5 EAK89820.1 - 7.7 6.7 21.5 0.019 15.1 6.8 3.3 3 0 0 3 3 3 0 KIAA1045 RING finger PHD PF00628.29 EAK89820.1 - 9.5 6.2 25.6 0.52 10.2 11.0 3.3 3 0 0 3 3 3 0 PHD-finger CRAL_TRIO PF00650.20 EAK89821.1 - 2.7e-29 101.9 0.2 5.9e-29 100.8 0.2 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EAK89821.1 - 8.4e-07 29.1 0.3 5.9e-06 26.4 0.2 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain POTRA PF07244.15 EAK89823.1 - 0.003 18.1 2.0 0.0063 17.1 2.0 1.4 1 0 0 1 1 1 1 Surface antigen variable number repeat PKD_channel PF08016.12 EAK89823.1 - 0.0065 15.2 24.7 0.014 14.1 24.7 1.4 1 0 0 1 1 1 1 Polycystin cation channel DUF1687 PF07955.11 EAK89823.1 - 0.08 13.4 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1687) Fijivirus_P9-2 PF06837.11 EAK89823.1 - 0.17 11.3 0.0 0.17 11.3 0.0 3.7 3 0 0 3 3 3 0 Fijivirus P9-2 protein UPF0004 PF00919.20 EAK89824.1 - 2.3e-18 66.0 0.3 5.8e-18 64.7 0.3 1.7 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 EAK89824.1 - 1.3e-17 64.6 0.0 3.1e-17 63.4 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Rad4 PF03835.15 EAK89825.1 - 1.3e-19 70.3 8.5 6.6e-15 55.1 4.4 2.7 2 0 0 2 2 2 2 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EAK89825.1 - 2.7e-16 59.7 0.1 5.4e-16 58.8 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EAK89825.1 - 2.5e-12 46.4 0.0 5.5e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EAK89825.1 - 0.045 14.7 0.6 0.045 14.7 0.6 2.4 2 1 0 2 2 2 0 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EAK89825.1 - 0.11 13.0 0.1 0.44 11.0 0.0 2.0 2 0 0 2 2 2 0 Transglutaminase-like superfamily NuA4 PF09340.10 EAK89826.1 - 3e-20 71.9 0.1 7.2e-20 70.6 0.1 1.6 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 SLBP_RNA_bind PF15247.6 EAK89827.1 - 2.9e-18 65.7 2.9 2.9e-18 65.7 2.9 3.0 3 1 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain STT3 PF02516.14 EAK89828.1 - 3e-83 280.4 44.1 8.2e-83 279.0 44.1 1.6 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Apyrase PF06079.11 EAK89829.1 - 2.5e-112 374.9 0.9 2.8e-112 374.7 0.9 1.0 1 0 0 1 1 1 1 Apyrase Reg_prop PF07494.11 EAK89829.1 - 0.0055 16.8 1.1 7.9 7.1 0.1 3.5 3 0 0 3 3 3 2 Two component regulator propeller RsgI_N PF12791.7 EAK89829.1 - 0.1 12.5 0.1 0.31 11.0 0.1 1.7 1 0 0 1 1 1 0 Anti-sigma factor N-terminus XPG_I PF00867.18 EAK89830.1 - 1.1e-20 73.8 0.8 4.4e-20 71.8 0.1 2.3 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EAK89830.1 - 3.2e-18 66.1 0.0 1.4e-17 64.0 0.0 2.1 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I_2 PF12813.7 EAK89830.1 - 4.9e-05 22.9 0.0 9.6e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing MFAP1 PF06991.11 EAK89831.1 - 1.3e-06 28.4 1.2 1.6e-06 28.1 1.2 1.1 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing DUF4919 PF16266.5 EAK89831.1 - 0.0064 16.5 0.0 0.0066 16.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4919) Ccdc124 PF06244.12 EAK89831.1 - 0.042 14.4 0.4 0.049 14.2 0.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 DOT1 PF08123.13 EAK89832.1 - 7.5e-05 22.4 0.1 0.00019 21.1 0.1 1.6 1 0 0 1 1 1 1 Histone methylation protein DOT1 GidB PF02527.15 EAK89832.1 - 0.048 13.0 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Toxin_35 PF10530.9 EAK89832.1 - 0.23 11.5 6.6 0.18 11.8 2.9 2.4 2 0 0 2 2 2 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold HHH_2 PF12826.7 EAK89834.1 - 0.15 12.2 0.0 11 6.2 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix motif TSP_1 PF00090.19 EAK89835.1 - 7.7e-06 26.0 39.4 1e-05 25.7 2.7 5.1 4 0 0 4 4 4 3 Thrombospondin type 1 domain hEGF PF12661.7 EAK89835.1 - 0.076 13.7 2.7 0.38 11.5 0.1 3.0 2 0 0 2 2 2 0 Human growth factor-like EGF RRM_1 PF00076.22 EAK89836.1 - 5.4e-05 22.9 0.1 1.8 8.4 0.0 3.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5082 PF16888.5 EAK89837.1 - 0.015 15.6 7.2 0.015 15.6 7.2 7.8 4 2 3 8 8 8 0 Domain of unknown function (DUF5082) DASH_Dam1 PF08653.10 EAK89837.1 - 0.19 11.5 13.8 2.3 8.1 0.2 5.3 4 1 0 4 4 4 0 DASH complex subunit Dam1 PAS_9 PF13426.7 EAK89837.1 - 3.8 7.8 8.5 1.1 9.6 1.6 3.5 3 0 0 3 3 3 0 PAS domain zf-primase PF09329.11 EAK89838.1 - 8.2e-08 31.9 0.9 8.2e-08 31.9 0.9 2.1 2 0 0 2 2 2 1 Primase zinc finger zf-C3Hc3H PF13891.6 EAK89838.1 - 0.018 15.4 0.1 0.072 13.5 0.1 2.1 1 0 0 1 1 1 0 Potential DNA-binding domain RRM_1 PF00076.22 EAK89839.1 - 1.4e-13 50.4 0.0 2.3e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Stk19 PF10494.9 EAK89840.1 - 0.28 10.9 4.7 0.54 9.9 4.7 1.7 1 1 0 1 1 1 0 Serine-threonine protein kinase 19 Torus PF16131.5 EAK89841.1 - 7.4e-06 26.6 8.1 0.0014 19.3 0.2 2.4 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EAK89841.1 - 2.7e-05 24.1 24.1 8.3e-05 22.5 3.0 3.8 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH PF00642.24 EAK89841.1 - 7.3e-05 22.6 2.6 7.3e-05 22.6 2.6 4.0 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EAK89841.1 - 7.4e-05 22.5 15.8 0.0029 17.4 1.2 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EAK89841.1 - 0.2 12.2 18.1 0.88 10.1 1.9 3.5 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EAK89841.1 - 1.5 9.1 12.6 6.9 6.9 1.6 2.7 1 1 1 2 2 2 0 Zinc-finger containing family PI3_PI4_kinase PF00454.27 EAK89842.1 - 7e-21 75.2 0.8 2.5e-20 73.3 0.8 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EAK89842.1 - 3.2e-09 36.5 0.2 3.2e-09 36.5 0.2 4.3 4 1 0 4 4 4 2 FAT domain FATC PF02260.20 EAK89842.1 - 8e-05 22.4 0.3 0.0016 18.2 0.0 2.7 2 0 0 2 2 2 1 FATC domain ParcG PF10274.9 EAK89842.1 - 0.025 14.7 0.4 0.44 10.6 0.0 3.1 2 0 0 2 2 2 0 Parkin co-regulated protein PI3_PI4_kinase PF00454.27 EAK89843.1 - 2.1e-36 126.0 0.1 5e-26 92.0 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EAK89843.1 - 3.2e-23 82.1 1.5 1.1e-22 80.4 1.5 1.8 1 1 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Prenyltrans PF00432.21 EAK89844.1 - 1.1e-36 124.2 13.9 3e-11 42.9 0.5 5.5 7 0 0 7 7 7 4 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EAK89844.1 - 3e-05 23.2 0.0 0.00063 18.9 0.0 2.3 2 0 0 2 2 2 1 A-macroglobulin TED domain SQHop_cyclase_N PF13249.6 EAK89844.1 - 9.1e-05 21.7 0.0 0.0061 15.7 0.0 2.3 1 1 0 2 2 2 2 Squalene-hopene cyclase N-terminal domain EGF_CA PF07645.15 EAK89844.1 - 6.5 7.1 7.7 4 7.7 0.3 2.5 2 0 0 2 2 2 0 Calcium-binding EGF domain DUF3546 PF12066.8 EAK89845.1 - 3.2e-22 78.8 2.1 4.1e-22 78.5 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 EAK89845.1 - 2.7e-10 40.9 0.2 6.1e-10 39.8 0.2 1.7 1 0 0 1 1 1 1 Arsenite-resistance protein 2 Mrr_cat_2 PF13156.6 EAK89845.1 - 0.0044 16.9 0.2 0.018 15.0 0.2 2.2 1 0 0 1 1 1 1 Restriction endonuclease DEAD PF00270.29 EAK89846.1 - 6.7e-24 84.6 0.0 1.5e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89846.1 - 3.5e-17 62.7 0.3 3.5e-17 62.7 0.3 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89846.1 - 0.0002 21.4 0.0 0.00075 19.5 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Acetyltransf_1 PF00583.25 EAK89847.1 - 7.9e-07 29.3 0.0 1.3e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EAK89847.1 - 0.0023 18.3 0.0 0.0041 17.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Cnd1 PF12717.7 EAK89848.1 - 3.2e-05 24.0 0.6 3.2e-05 24.0 0.6 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DXPR_C PF13288.6 EAK89848.1 - 0.0083 16.4 0.1 0.027 14.7 0.1 1.9 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain D123 PF07065.14 EAK89850.1 - 4.5e-33 114.7 0.5 7.2e-33 114.1 0.5 1.4 1 0 0 1 1 1 1 D123 DUF21 PF01595.20 EAK89851.1 - 7.4e-37 126.7 1.3 1.1e-36 126.2 1.3 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EAK89851.1 - 0.011 16.1 0.4 6.1 7.4 0.0 3.3 2 2 1 3 3 3 0 CBS domain BCIP PF13862.6 EAK89853.1 - 3.6e-36 124.9 1.0 5.1e-36 124.4 1.0 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DnaGprimase_HBD PF16730.5 EAK89853.1 - 0.071 13.2 0.1 0.22 11.6 0.0 1.8 1 1 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain Inhibitor_I42 PF09394.10 EAK89854.1 - 2.4e-13 50.3 0.0 3.2e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 DUF2500 PF10694.9 EAK89854.1 - 0.018 15.5 0.0 0.035 14.6 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) HALZ PF02183.18 EAK89855.1 - 0.00035 20.7 7.3 0.00035 20.7 7.3 4.1 4 1 0 4 4 4 1 Homeobox associated leucine zipper DUF4164 PF13747.6 EAK89855.1 - 0.52 10.6 6.0 9.4 6.6 2.5 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) ORC3_N PF07034.11 EAK89856.1 - 4.2e-08 32.7 5.2 3.2e-07 29.8 0.0 3.0 2 1 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EAK89856.1 - 3.8e-07 30.3 0.1 8.1e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal DUF2683 PF10884.8 EAK89856.1 - 0.75 10.1 6.9 1.3 9.3 0.4 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2683) MutS_III PF05192.18 EAK89856.1 - 1.2 9.4 4.3 0.65 10.2 0.3 2.5 2 1 0 2 2 2 0 MutS domain III DUF3656 PF12392.8 EAK89858.1 - 0.11 13.2 0.9 0.17 12.5 0.9 1.3 1 0 0 1 1 1 0 Collagenase Glycos_transf_2 PF00535.26 EAK89861.1 - 2.1e-18 66.7 0.0 5.5e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EAK89861.1 - 0.00023 21.4 6.0 0.0026 18.0 0.0 3.7 4 0 0 4 4 4 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EAK89861.1 - 0.0007 19.6 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EAK89861.1 - 0.003 17.2 0.6 0.0076 15.9 0.6 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Sigma_reg_N PF13800.6 EAK89861.1 - 7.9 6.8 12.3 26 5.2 0.2 2.9 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Methyltransf_10 PF05971.12 EAK89862.1 - 8.5e-59 199.3 7.3 1.6e-37 129.5 1.2 2.8 2 1 0 2 2 2 2 RNA methyltransferase AMPK1_CBM PF16561.5 EAK89863.1 - 1.3e-23 83.0 0.5 6.3e-23 80.8 0.1 2.0 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase Not1 PF04054.15 EAK89864.1 - 9.9e-108 360.3 1.3 9.9e-108 360.3 1.3 3.3 2 1 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EAK89864.1 - 1.7e-52 178.1 1.8 2.3e-35 122.0 0.0 2.7 2 0 0 2 2 2 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EAK89864.1 - 1.1e-48 164.8 0.1 4.6e-48 162.9 0.1 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EAK89864.1 - 1.2e-29 102.8 0.4 4.2e-29 101.1 0.4 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain XRN_N PF03159.18 EAK89865.1 - 1.2e-90 303.2 0.0 2.6e-90 302.1 0.0 1.6 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EAK89865.1 - 4.5e-56 190.7 20.8 3.9e-28 98.6 0.0 4.4 4 0 0 4 4 4 3 Xrn1 helical domain SH3_12 PF18129.1 EAK89865.1 - 1.1e-17 63.9 0.1 4.7e-16 58.6 0.1 2.7 2 0 0 2 2 2 1 Xrn1 SH3-like domain Pico_P2B PF01552.17 EAK89867.1 - 0.22 11.7 3.4 0.32 11.2 0.2 2.8 2 0 0 2 2 2 0 Picornavirus 2B protein DUF4903 PF16246.5 EAK89868.1 - 0.032 13.9 1.1 0.054 13.1 0.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4903) DUF5390 PF17365.2 EAK89868.1 - 0.034 14.4 3.1 1.5 9.0 0.1 2.4 2 1 0 3 3 3 0 Family of unknown function (DUF5390) Ribosomal_L5_C PF00673.21 EAK89870.1 - 5.2e-23 81.0 0.1 1.1e-22 80.0 0.0 1.5 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EAK89870.1 - 2.1e-19 69.6 0.2 3.6e-19 68.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 RabGAP-TBC PF00566.18 EAK89871.1 - 1.7e-48 165.1 5.4 3.5e-48 164.1 5.4 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain LRR_4 PF12799.7 EAK89872.1 - 1.3e-05 25.4 33.9 0.0016 18.8 0.4 6.4 5 1 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EAK89872.1 - 0.00021 21.0 0.4 0.00021 21.0 0.4 4.1 4 1 1 5 5 5 2 Leucine rich repeat LRR_6 PF13516.6 EAK89872.1 - 0.2 11.8 10.8 79 3.7 0.2 6.5 7 0 0 7 7 7 0 Leucine Rich repeat DUF3273 PF11677.8 EAK89873.1 - 1.7e-85 286.5 9.8 2e-85 286.3 9.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) DUF996 PF06195.13 EAK89873.1 - 0.0087 16.3 12.4 0.051 13.9 3.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF996) Fumarate_red_C PF02300.17 EAK89873.1 - 0.11 12.6 1.0 0.16 12.0 0.1 1.8 2 0 0 2 2 2 0 Fumarate reductase subunit C DUF3273 PF11677.8 EAK89874.1 - 5.5e-60 202.9 12.6 7.2e-60 202.5 12.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) ERGIC_N PF13850.6 EAK89874.1 - 0.27 11.6 0.1 0.27 11.6 0.1 2.1 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Diphthamide_syn PF01866.17 EAK89875.1 - 7.3e-76 255.5 1.0 1.1e-75 255.0 1.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein PHD PF00628.29 EAK89876.1 - 3.5e-06 26.8 1.9 3.5e-06 26.8 1.9 2.1 2 0 0 2 2 2 1 PHD-finger DUF3795 PF12675.7 EAK89876.1 - 0.54 10.7 1.9 2.3 8.7 1.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) DEAD PF00270.29 EAK89877.1 - 2.3e-42 144.7 0.6 1.5e-41 142.0 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89877.1 - 1.9e-21 76.5 0.3 1.5e-20 73.6 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EAK89877.1 - 3.4e-12 46.4 0.1 7.5e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) AAA_22 PF13401.6 EAK89877.1 - 0.037 14.3 0.2 0.29 11.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain PIG-X PF08320.12 EAK89879.1 - 9.8e-12 45.2 0.1 3.4e-11 43.5 0.0 1.9 2 1 0 2 2 2 1 PIG-X / PBN1 Exo_endo_phos PF03372.23 EAK89880.1 - 4.4e-06 26.4 0.0 1.2e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PTN_MK_C PF01091.18 EAK89882.1 - 2.2 8.7 5.6 9.1 6.8 1.1 2.8 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain DUF4982 PF16355.5 EAK89883.1 - 0.021 14.8 0.0 0.052 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4982) MFS_1 PF07690.16 EAK89884.1 - 7.4e-05 21.8 36.1 7.4e-05 21.8 36.1 3.5 2 1 1 3 3 3 2 Major Facilitator Superfamily Mito_carr PF00153.27 EAK89885.1 - 7e-31 106.0 5.5 9e-15 54.4 0.3 4.6 3 2 0 3 3 3 3 Mitochondrial carrier protein Thia_YuaJ PF09515.10 EAK89885.1 - 0.043 13.8 4.6 0.16 12.0 0.3 2.6 2 1 0 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) Keratin_assoc PF09775.9 EAK89885.1 - 0.046 13.4 0.4 0.046 13.4 0.4 1.9 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 Mito_carr PF00153.27 EAK89886.1 - 2.4e-12 46.6 0.0 3.7e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein Sec1 PF00995.23 EAK89887.1 - 6e-78 263.5 8.5 7.2e-78 263.2 8.5 1.1 1 0 0 1 1 1 1 Sec1 family Geminin PF07412.12 EAK89887.1 - 0.091 12.5 0.6 0.19 11.5 0.6 1.4 1 0 0 1 1 1 0 Geminin DUF1722 PF08349.11 EAK89887.1 - 0.095 13.0 0.6 0.34 11.2 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) NLRC4_HD PF17889.1 EAK89887.1 - 0.1 12.9 6.4 0.94 9.8 0.1 4.0 4 0 0 4 4 4 0 NLRC4 helical domain NAC PF01849.18 EAK89888.1 - 2.7e-17 62.5 0.0 6.4e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 NAC domain STI1 PF17830.1 EAK89888.1 - 0.0026 17.6 0.3 0.01 15.8 0.3 2.0 2 0 0 2 2 2 1 STI1 domain PEPCK_N PF17297.2 EAK89888.1 - 0.072 12.7 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain SRR1 PF07985.12 EAK89889.1 - 1.5e-08 34.6 0.0 3.4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 SRR1 Phosphorylase PF00343.20 EAK89891.1 - 1e-298 992.6 0.0 1.2e-298 992.4 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase TIG_plexin PF17960.1 EAK89891.1 - 0.05 13.6 0.0 1.6 8.8 0.0 2.5 2 0 0 2 2 2 0 TIG domain DUF4994 PF16385.5 EAK89891.1 - 0.14 12.1 0.2 0.35 10.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function Ribosomal_L21e PF01157.18 EAK89892.1 - 1.6e-43 146.6 2.1 2.1e-43 146.3 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e RNA_replicase_B PF03431.13 EAK89892.1 - 0.022 13.2 0.0 0.026 13.0 0.0 1.0 1 0 0 1 1 1 0 RNA replicase, beta-chain SepSecS PF05889.13 EAK89892.1 - 0.083 11.6 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Evr1_Alr PF04777.13 EAK89893.1 - 7.9e-11 42.3 0.1 2.6e-10 40.6 0.1 1.9 1 0 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 EAK89893.1 - 5.4e-07 29.6 0.0 1.4e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EAK89893.1 - 0.00089 19.2 0.0 0.0034 17.3 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EAK89893.1 - 0.15 12.5 0.1 0.44 11.0 0.1 1.8 1 1 0 1 1 1 0 Thioredoxin-like domain zinc_ribbon_10 PF10058.9 EAK89893.1 - 7 6.5 6.4 8.2 6.2 0.4 2.9 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Ion_trans PF00520.31 EAK89895.1 - 0.00052 19.3 5.4 0.00068 18.9 5.4 1.2 1 0 0 1 1 1 1 Ion transport protein Tmemb_18A PF09771.9 EAK89895.1 - 0.091 13.2 2.2 0.095 13.1 1.4 1.4 1 1 0 1 1 1 0 Transmembrane protein 188 DUF1211 PF06736.11 EAK89895.1 - 0.41 11.1 4.1 0.82 10.2 3.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1211) NAD4L PF06235.11 EAK89895.1 - 0.57 10.2 9.1 1.2 9.2 1.1 2.1 1 1 1 2 2 2 0 NADH dehydrogenase subunit 4L (NAD4L) PPTA PF01239.22 EAK89896.1 - 2.1e-27 94.0 20.0 2.4e-08 33.4 0.3 5.5 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat HTH_Tnp_1_2 PF13022.6 EAK89896.1 - 1.5 9.0 4.3 2.1 8.5 0.2 2.7 2 1 1 3 3 3 0 Helix-turn-helix of insertion element transposase Rpr2 PF04032.16 EAK89897.1 - 2.5e-08 34.1 2.2 8.9e-08 32.3 2.2 2.0 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Nucleoporin_FG PF13634.6 EAK89898.1 - 0.001 19.8 101.3 0.19 12.6 8.9 8.2 3 2 4 7 7 7 5 Nucleoporin FG repeat region MORN PF02493.20 EAK89899.1 - 1.3e-94 304.8 95.7 3.7e-09 36.0 2.2 14.8 15 0 0 15 15 15 14 MORN repeat PA_decarbox PF05870.11 EAK89899.1 - 1.2 8.8 6.6 1.7 8.3 0.8 2.8 2 0 0 2 2 2 0 Phenolic acid decarboxylase (PAD) DUF2158 PF09926.9 EAK89899.1 - 5.5 6.8 9.9 33 4.3 0.0 5.7 3 2 2 6 6 6 0 Uncharacterized small protein (DUF2158) Fib_alpha PF08702.10 EAK89900.1 - 0.0092 16.2 3.5 0.0092 16.2 3.5 3.7 4 1 0 4 4 4 1 Fibrinogen alpha/beta chain family PKcGMP_CC PF16808.5 EAK89900.1 - 0.025 14.4 0.3 0.066 13.1 0.3 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Flagellin_C PF00700.21 EAK89900.1 - 0.12 12.8 0.1 0.12 12.8 0.1 3.5 4 0 0 4 4 4 0 Bacterial flagellin C-terminal helical region TSC22 PF01166.18 EAK89900.1 - 2 8.8 6.5 0.6 10.5 0.8 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family MOZ_SAS PF01853.18 EAK89901.1 - 1.4e-72 243.2 0.1 2e-72 242.6 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EAK89901.1 - 1.1e-18 66.5 0.3 1.1e-18 66.5 0.3 2.3 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 EAK89901.1 - 5.2e-14 51.9 0.1 1.5e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EAK89901.1 - 0.0025 18.2 0.0 0.0065 16.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EAK89901.1 - 0.0048 17.1 0.1 0.056 13.7 0.1 2.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family RskA PF10099.9 EAK89902.1 - 0.0035 17.7 10.6 0.18 12.1 1.5 2.5 2 0 0 2 2 2 2 Anti-sigma-K factor rskA DUF4148 PF13663.6 EAK89902.1 - 0.24 11.6 10.5 2.1 8.6 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Ribosomal_60s PF00428.19 EAK89902.1 - 0.41 11.3 17.6 1.5 9.4 7.4 3.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Chorion_2 PF03964.15 EAK89902.1 - 2.6 8.9 13.6 0.91 10.4 2.2 3.2 3 0 0 3 3 3 0 Chorion family 2 FtsJ PF01728.19 EAK89905.1 - 0.097 12.8 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase FKBP_C PF00254.28 EAK89907.1 - 1.4e-16 60.6 0.0 3.1e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 EAK89907.1 - 1.5e-07 32.3 0.0 2.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase APC_u14 PF16635.5 EAK89907.1 - 0.011 16.2 0.4 0.023 15.2 0.4 1.5 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr NTP_transf_2 PF01909.23 EAK89908.1 - 0.00025 21.2 0.0 0.00083 19.6 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EAK89908.1 - 0.0015 18.6 0.1 0.0046 17.0 0.1 1.8 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Tai4 PF16695.5 EAK89908.1 - 0.07 13.7 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase immunity protein UPAR_LY6_2 PF16975.5 EAK89908.1 - 0.077 13.2 2.2 0.95 9.7 0.1 2.6 2 0 0 2 2 2 0 Ly6/PLAUR domain-containing protein 6, Lypd6 TPX2_importin PF12214.8 EAK89909.1 - 0.052 13.7 25.2 0.14 12.4 0.3 4.7 2 2 1 4 4 4 0 Cell cycle regulated microtubule associated protein DUF573 PF04504.14 EAK89909.1 - 0.2 12.3 4.2 0.15 12.7 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF573 SDA1 PF05285.12 EAK89911.1 - 0.017 14.6 12.6 0.019 14.4 12.6 1.1 1 0 0 1 1 1 0 SDA1 SRTM1 PF15872.5 EAK89911.1 - 0.063 13.4 0.2 0.31 11.2 0.0 2.1 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 DUF5393 PF17371.2 EAK89911.1 - 0.11 10.6 0.3 0.13 10.3 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5393) Nop14 PF04147.12 EAK89911.1 - 0.58 8.3 14.0 0.72 8.0 14.0 1.0 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 EAK89911.1 - 8.9 6.0 10.5 3 7.5 0.3 2.7 1 1 1 2 2 2 0 FAM176 family SLX9 PF15341.6 EAK89912.1 - 0.065 13.6 8.1 0.25 11.7 2.3 2.3 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 SNAP-25 PF00835.19 EAK89913.1 - 0.017 15.4 0.2 0.054 13.8 0.1 1.9 2 0 0 2 2 2 0 SNAP-25 family RRN3 PF05327.11 EAK89914.1 - 2.1e-13 49.7 6.5 4.3e-13 48.7 6.5 1.5 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Methyltransf_31 PF13847.6 EAK89915.1 - 7.3e-12 45.3 0.5 1.7e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EAK89915.1 - 4.2e-10 40.2 0.0 4.8e-06 27.2 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EAK89915.1 - 7.2e-10 39.5 0.2 7.2e-07 29.9 0.0 3.3 3 0 0 3 3 3 1 Methyltransferase domain Spermine_synth PF01564.17 EAK89915.1 - 5.1e-09 35.8 0.3 7.5e-07 28.7 0.2 2.5 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_11 PF08241.12 EAK89915.1 - 6.6e-08 33.1 0.0 2.1e-05 25.1 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EAK89915.1 - 7.7e-07 28.8 0.0 0.0076 15.8 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase small domain Methyltransf_23 PF13489.6 EAK89915.1 - 1.3e-05 25.1 0.0 0.00063 19.6 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EAK89915.1 - 0.00086 19.3 0.0 0.11 12.5 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain EntA_Immun PF08951.10 EAK89915.1 - 0.012 16.0 0.6 3.6 8.0 0.2 3.2 2 0 0 2 2 2 0 Enterocin A Immunity NodS PF05401.11 EAK89915.1 - 0.14 11.8 0.0 0.65 9.6 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein S (NodS) SF3A2 PF16835.5 EAK89916.1 - 5e-25 87.7 0.3 8.1e-25 87.0 0.3 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EAK89916.1 - 2e-06 28.0 1.0 2e-06 28.0 1.0 2.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EAK89916.1 - 0.044 14.1 2.5 0.76 10.2 0.3 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) CENP-F_leu_zip PF10473.9 EAK89918.1 - 0.012 15.6 8.2 0.012 15.6 8.2 6.3 4 1 2 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Exostosin PF03016.15 EAK89923.1 - 9.7e-09 34.8 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Exostosin family DUF489 PF04356.12 EAK89924.1 - 0.018 15.1 0.2 0.028 14.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) STAG PF08514.11 EAK89925.1 - 0.00047 20.0 0.8 0.0024 17.8 0.0 2.8 2 0 0 2 2 2 1 STAG domain YqgC PF17430.2 EAK89927.1 - 0.17 12.0 0.8 0.48 10.5 0.8 1.7 1 0 0 1 1 1 0 Uncharacterized YqgC-like Bax1-I PF01027.20 EAK89928.1 - 1.1e-29 103.8 29.9 1.3e-29 103.5 29.9 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2070 PF09843.9 EAK89928.1 - 7.7 4.7 21.7 9.6 4.4 21.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) tRNA-synt_1b PF00579.25 EAK89929.1 - 5.6e-55 186.7 0.0 7.1e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF2013 PF09431.10 EAK89930.1 - 1.1e-05 25.7 0.1 1.8e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Folate_rec PF03024.14 EAK89931.1 - 1.7e-23 83.4 11.7 2.1e-23 83.0 11.7 1.2 1 0 0 1 1 1 1 Folate receptor family RCC1 PF00415.18 EAK89933.1 - 6.6e-29 100.3 0.1 1.3e-09 38.5 0.1 6.7 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EAK89933.1 - 1.5e-23 82.0 18.5 4.8e-06 26.2 0.3 5.6 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RPAP3_C PF13877.6 EAK89934.1 - 1.8e-07 31.6 2.5 1.8e-07 31.6 2.5 2.5 2 1 1 3 3 3 1 Potential Monad-binding region of RPAP3 N6_N4_Mtase PF01555.18 EAK89934.1 - 0.0018 18.0 1.8 0.0047 16.7 1.4 2.0 1 1 1 2 2 2 1 DNA methylase TPR_1 PF00515.28 EAK89934.1 - 0.023 14.5 0.6 0.38 10.7 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4119 PF13494.6 EAK89934.1 - 0.029 14.5 1.3 6 7.1 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF4119) HGTP_anticodon PF03129.20 EAK89934.1 - 0.14 12.3 1.8 0.36 11.0 0.8 2.3 2 0 0 2 2 2 0 Anticodon binding domain TPR_2 PF07719.17 EAK89934.1 - 0.23 11.7 1.6 1.1 9.5 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_WhiA PF02650.14 EAK89934.1 - 0.37 11.2 4.1 0.43 10.9 0.0 2.9 3 0 0 3 3 3 0 WhiA C-terminal HTH domain Pox_Ag35 PF03286.14 EAK89936.1 - 0.16 11.8 3.7 0.2 11.5 3.7 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Renin_r PF07850.14 EAK89936.1 - 0.63 10.7 3.8 2.7 8.7 3.8 2.2 1 1 0 1 1 1 0 Renin receptor-like protein DUF4834 PF16118.5 EAK89936.1 - 2.4 9.2 11.8 14 6.8 6.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) BsuBI_PstI_RE PF06616.11 EAK89939.1 - 0.15 11.4 2.6 0.22 10.8 0.4 2.4 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain Putative_G5P PF17426.2 EAK89940.1 - 0.0047 17.0 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 Putative Gamma DNA binding protein G5P PDZ_4 PF17816.1 EAK89940.1 - 0.029 14.8 0.0 0.059 13.8 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Spc24 PF08286.11 EAK89940.1 - 0.057 13.7 0.8 0.18 12.0 0.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Mucin PF01456.17 EAK89942.1 - 6.6 6.7 14.4 14 5.6 14.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Rad9 PF04139.13 EAK89943.1 - 3.9e-15 56.0 0.1 7.2e-15 55.1 0.1 1.3 1 0 0 1 1 1 1 Rad9 Sec7 PF01369.20 EAK89944.1 - 6.6e-52 175.8 0.6 1.7e-51 174.5 0.6 1.8 1 0 0 1 1 1 1 Sec7 domain RabGAP-TBC PF00566.18 EAK89944.1 - 1e-26 94.0 9.0 1e-26 94.0 9.0 2.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain INCENP_ARK-bind PF03941.15 EAK89945.1 - 1.5e-09 37.6 0.0 4.6e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Trypan_PARP PF05887.11 EAK89945.1 - 0.013 15.5 0.3 0.013 15.5 0.3 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) NESP55 PF06390.12 EAK89945.1 - 2.2 7.8 7.4 4.8 6.7 7.4 1.5 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Sel1 PF08238.12 EAK89946.1 - 1e-25 89.6 15.9 4.3e-08 33.6 0.3 9.2 9 0 0 9 9 9 8 Sel1 repeat Ras PF00071.22 EAK89947.1 - 5.9e-67 224.3 0.7 6.9e-67 224.1 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAK89947.1 - 5e-37 126.8 0.6 7e-37 126.3 0.2 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAK89947.1 - 1.4e-17 63.7 0.2 1.8e-17 63.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EAK89947.1 - 1.6e-06 27.6 0.1 1.9e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EAK89947.1 - 4.4e-06 26.4 0.5 1e-05 25.2 0.5 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EAK89947.1 - 2.5e-05 24.3 0.1 0.00012 22.2 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAK89947.1 - 7.1e-05 22.8 0.3 0.12 12.3 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EAK89947.1 - 0.00012 21.6 0.1 0.00018 21.0 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NAGLU PF05089.12 EAK89947.1 - 0.011 14.7 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain AAA_16 PF13191.6 EAK89947.1 - 0.02 15.3 0.0 0.026 14.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 EAK89947.1 - 0.029 13.9 0.1 0.39 10.2 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 EAK89947.1 - 0.037 13.6 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 EAK89947.1 - 0.046 14.0 0.0 0.088 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EAK89947.1 - 0.062 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EAK89947.1 - 0.062 13.3 0.0 0.099 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LANC_like PF05147.13 EAK89947.1 - 0.091 11.3 0.0 0.21 10.1 0.0 1.5 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein TniB PF05621.11 EAK89947.1 - 0.12 11.7 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DEAD PF00270.29 EAK89948.1 - 2.3e-40 138.2 0.0 4.2e-40 137.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK89948.1 - 5e-30 104.1 0.4 3.4e-29 101.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK89948.1 - 4.5e-07 30.0 0.0 1.1e-06 28.8 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Methyltr_RsmB-F PF01189.17 EAK89949.1 - 6.2e-66 221.9 0.0 9.7e-66 221.2 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EAK89949.1 - 5.5e-08 33.2 0.0 1.6e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EAK89949.1 - 0.0034 17.5 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Glyco_hydro_63N PF16923.5 EAK89949.1 - 0.025 14.7 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 N-terminal domain Gpi16 PF04113.14 EAK89950.1 - 2.1e-16 59.5 0.9 1.6e-15 56.6 0.9 1.9 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component DUF3450 PF11932.8 EAK89951.1 - 0.015 14.6 8.9 0.022 14.1 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CorA PF01544.18 EAK89951.1 - 2.7 7.2 6.9 3.9 6.7 6.9 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ArAE_2_N PF10337.9 EAK89951.1 - 3 6.8 9.5 4.8 6.1 9.5 1.3 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal HARP PF07443.13 EAK89952.1 - 9.3e-05 22.0 1.2 0.08 12.6 0.1 2.7 2 0 0 2 2 2 2 HepA-related protein (HARP) JAB PF01398.21 EAK89953.1 - 1.7e-32 111.9 0.0 3e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EAK89953.1 - 1.6e-10 40.8 0.0 2.3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.6 EAK89953.1 - 1.3e-09 38.5 0.3 2.1e-09 37.8 0.3 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function CBM_48 PF02922.18 EAK89954.1 - 5.1e-22 78.0 0.3 8.6e-21 74.1 0.1 2.8 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 EAK89954.1 - 4.7e-18 65.5 0.2 3.9e-17 62.5 0.2 2.5 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EAK89954.1 - 2.5e-11 43.7 0.1 0.00014 21.6 0.0 3.2 1 1 1 2 2 2 2 Alpha amylase, catalytic domain RNA_pol_Rpb1_5 PF04998.17 EAK89955.1 - 3.6e-91 305.3 3.3 1.2e-90 303.6 3.3 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EAK89955.1 - 6.6e-74 249.0 0.0 6.6e-74 249.0 0.0 2.4 2 1 1 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EAK89955.1 - 2.2e-72 242.7 0.0 5e-72 241.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EAK89955.1 - 8e-37 126.6 0.0 3.4e-36 124.6 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EAK89955.1 - 3.9e-30 104.0 0.0 2.6e-29 101.3 0.0 2.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Octopine_DH PF02317.17 EAK89955.1 - 0.1 12.7 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain MAS20 PF02064.15 EAK89956.1 - 0.012 15.7 14.0 0.023 14.8 14.0 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor DUF2362 PF10154.9 EAK89956.1 - 0.17 10.8 8.5 0.21 10.5 8.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) DUF4407 PF14362.6 EAK89956.1 - 0.42 9.9 4.8 0.54 9.6 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 EAK89956.1 - 0.52 9.8 6.8 0.61 9.6 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EAK89956.1 - 2.7 7.0 11.9 3.4 6.7 11.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2207 PF09972.9 EAK89956.1 - 2.7 6.6 8.6 4.2 6.0 8.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) U79_P34 PF03064.16 EAK89956.1 - 4.9 6.4 14.0 6.2 6.1 14.0 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 AAA_11 PF13086.6 EAK89956.1 - 6.1 6.5 9.8 7.6 6.2 9.8 1.1 1 0 0 1 1 1 0 AAA domain Caldesmon PF02029.15 EAK89956.1 - 8.4 5.0 24.3 10 4.8 24.3 1.1 1 0 0 1 1 1 0 Caldesmon PUB PF09409.10 EAK89957.1 - 0.021 14.8 0.3 0.034 14.1 0.3 1.4 1 1 0 1 1 1 0 PUB domain DUF3741 PF12552.8 EAK89957.1 - 0.18 11.8 2.2 0.22 11.5 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3741) Glyco_transf_34 PF05637.12 EAK89958.1 - 0.0051 16.6 1.3 0.0051 16.6 1.3 2.1 2 1 0 2 2 2 1 galactosyl transferase GMA12/MNN10 family Ribosomal_L32e PF01655.18 EAK89959.1 - 4.1e-47 159.1 0.2 5.4e-47 158.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L32 pKID PF02173.17 EAK89959.1 - 0.09 12.3 0.3 0.22 11.0 0.3 1.6 1 0 0 1 1 1 0 pKID domain IGR PF09597.10 EAK89959.1 - 0.11 12.6 1.9 5.3 7.2 0.7 2.9 3 0 0 3 3 3 0 IGR protein motif Epsilon_antitox PF08998.11 EAK89960.1 - 0.054 13.8 0.5 0.077 13.3 0.5 1.2 1 0 0 1 1 1 0 Bacterial epsilon antitoxin FYVE PF01363.21 EAK89960.1 - 1.9 8.7 16.0 14 5.9 16.0 2.4 1 1 0 1 1 1 0 FYVE zinc finger NLE PF08154.12 EAK89961.1 - 2e-13 50.6 0.1 8.7e-13 48.6 0.0 2.1 2 0 0 2 2 2 1 NLE (NUC135) domain WD40 PF00400.32 EAK89961.1 - 6.6e-09 36.3 5.7 0.037 14.9 0.1 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK89961.1 - 0.01 16.1 0.6 9 6.7 0.0 4.1 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Elicitin PF00964.17 EAK89961.1 - 0.43 10.7 3.0 6.3 7.0 0.5 2.5 1 1 1 2 2 2 0 Elicitin PI3_PI4_kinase PF00454.27 EAK89962.1 - 5.1e-29 101.8 0.7 1e-27 97.6 0.7 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GCP_C_terminal PF04130.13 EAK89963.1 - 8.3e-29 101.0 11.6 8.3e-29 101.0 11.6 2.6 2 0 0 2 2 2 2 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EAK89963.1 - 6.3e-22 78.6 2.2 6.3e-22 78.6 2.2 2.3 2 1 0 3 3 3 1 Gamma tubulin complex component N-terminal Hexapep PF00132.24 EAK89964.1 - 3.7e-15 55.0 20.0 2.7e-05 23.7 4.4 3.7 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EAK89964.1 - 1.1e-05 25.0 20.6 0.00016 21.4 6.1 3.9 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EAK89964.1 - 0.0028 15.9 7.0 0.0048 15.1 7.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) W2 PF02020.18 EAK89964.1 - 0.0029 17.7 0.3 0.0029 17.7 0.3 2.4 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 EAK89964.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase Fucokinase PF07959.12 EAK89964.1 - 0.032 13.2 7.0 0.12 11.3 6.9 1.9 1 1 0 1 1 1 0 L-fucokinase RRM_1 PF00076.22 EAK89965.1 - 2.2e-11 43.4 0.1 1.5e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAK89965.1 - 0.00063 19.5 0.1 0.015 15.2 0.1 2.5 2 0 0 2 2 2 1 Occluded RNA-recognition motif SUB1_ProdP9 PF18213.1 EAK89965.1 - 0.39 10.6 5.0 6.5 6.7 0.8 2.7 2 1 1 3 3 3 0 SUB1 protease Prodomain ProdP9 DUF4424 PF14415.6 EAK89967.1 - 0.17 11.1 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4424) Stk19 PF10494.9 EAK89969.1 - 2.5e-09 37.2 0.6 6.7e-09 35.8 0.6 1.7 1 1 0 1 1 1 1 Serine-threonine protein kinase 19 HTH_48 PF17906.1 EAK89970.1 - 0.035 14.2 0.3 0.16 12.1 0.1 2.3 2 0 0 2 2 2 0 HTH domain in Mos1 transposase DUF4834 PF16118.5 EAK89970.1 - 5.4 8.0 12.8 7.2 7.6 1.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) MID_MedPIWI PF18296.1 EAK89970.1 - 6.3 6.5 16.4 8.6 6.1 1.7 2.5 2 0 0 2 2 2 0 MID domain of medPIWI RNase_PH PF01138.21 EAK89972.1 - 1.7e-30 106.2 0.3 3.6e-30 105.2 0.2 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 DER1 PF04511.15 EAK89974.1 - 1.8e-34 119.4 8.2 2.6e-34 118.9 8.2 1.2 1 0 0 1 1 1 1 Der1-like family WIF PF02019.18 EAK89974.1 - 0.036 13.8 0.1 0.06 13.1 0.1 1.2 1 0 0 1 1 1 0 WIF domain DUF2070 PF09843.9 EAK89974.1 - 7.8 4.7 7.2 9.6 4.4 7.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Myotub-related PF06602.14 EAK89975.1 - 1.1e-121 406.1 0.8 2.6e-121 404.9 0.8 1.7 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EAK89975.1 - 0.0015 18.5 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EAK89975.1 - 0.011 15.5 0.6 0.11 12.3 0.0 2.7 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EAK89975.1 - 0.023 14.3 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase BRCA2 PF00634.18 EAK89975.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 BRCA2 repeat GatB_Yqey PF02637.18 EAK89975.1 - 0.24 11.3 1.6 0.37 10.7 0.2 2.1 2 1 0 2 2 2 0 GatB domain RPN6_N PF18055.1 EAK89977.1 - 2.6e-35 121.3 0.9 6.9e-35 119.9 0.1 2.2 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EAK89977.1 - 2.4e-15 56.9 4.2 2.4e-15 56.9 4.2 2.6 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 EAK89977.1 - 2.6e-05 23.8 0.1 5.9e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain DUF410 PF04190.13 EAK89977.1 - 0.0011 18.9 0.8 1.1 9.0 0.4 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF410) TPR_12 PF13424.6 EAK89977.1 - 0.0079 16.5 0.8 5.6 7.3 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat DDRGK PF09756.9 EAK89977.1 - 0.015 14.9 1.4 0.029 14.0 1.4 1.4 1 0 0 1 1 1 0 DDRGK domain RcbX PF02341.15 EAK89977.1 - 0.038 14.3 1.3 0.8 10.0 0.1 3.0 2 0 0 2 2 2 0 RbcX protein NAD_binding_6 PF08030.12 EAK89977.1 - 0.096 12.8 1.1 0.23 11.6 1.1 1.7 1 0 0 1 1 1 0 Ferric reductase NAD binding domain HTH_24 PF13412.6 EAK89977.1 - 0.1 12.2 1.1 0.62 9.7 0.1 2.7 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding PMC2NT PF08066.12 EAK89977.1 - 2.8 8.7 4.9 3.3 8.5 0.6 3.3 2 1 1 3 3 3 0 PMC2NT (NUC016) domain TPR_2 PF07719.17 EAK89977.1 - 3 8.2 6.6 31 5.0 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4407 PF14362.6 EAK89978.1 - 2.2 7.5 3.6 2.9 7.1 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SF-assemblin PF06705.11 EAK89979.1 - 1.5e-38 132.6 39.3 1.5e-38 132.6 39.3 1.6 2 0 0 2 2 2 1 SF-assemblin/beta giardin E6 PF00518.17 EAK89979.1 - 0.27 11.7 1.0 0.7 10.4 1.0 1.8 1 0 0 1 1 1 0 Early Protein (E6) DUF3086 PF11285.8 EAK89979.1 - 2.2 7.3 15.7 0.62 9.1 11.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3086) Exonuc_VII_L PF02601.15 EAK89979.1 - 5.9 6.4 33.2 3.2 7.2 17.2 2.9 1 1 1 3 3 3 0 Exonuclease VII, large subunit DUF4172 PF13776.6 EAK89979.1 - 6.7 7.1 12.8 0.24 11.7 1.8 3.7 3 2 1 4 4 4 0 Domain of unknown function (DUF4172) Ank_2 PF12796.7 EAK89980.1 - 2.7e-05 24.7 0.0 9.8e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EAK89980.1 - 8.8e-05 22.6 0.0 0.01 16.3 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EAK89980.1 - 0.0014 18.9 0.0 0.0082 16.4 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EAK89980.1 - 0.029 14.8 0.0 0.19 12.3 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat Orf78 PF06024.12 EAK89980.1 - 0.054 13.8 0.1 0.054 13.8 0.1 3.7 4 0 0 4 4 4 0 Orf78 (ac78) Ank_4 PF13637.6 EAK89980.1 - 0.054 14.1 0.0 4.4 8.0 0.0 2.9 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Neur_chan_memb PF02932.16 EAK89980.1 - 0.089 12.8 12.0 0.013 15.6 3.2 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SLATT_5 PF18160.1 EAK89980.1 - 2.8 7.2 7.4 0.41 9.9 1.0 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Thioredoxin PF00085.20 EAK89981.1 - 1.8e-09 37.5 0.1 1.5e-05 24.9 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 EAK89981.1 - 0.00011 21.7 1.3 0.00056 19.3 0.1 2.5 4 0 0 4 4 4 1 OST3 / OST6 family, transporter family TsaE PF02367.17 EAK89981.1 - 0.0037 17.3 0.0 0.0072 16.3 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Thioredoxin_6 PF13848.6 EAK89981.1 - 0.026 14.4 7.7 1.4 8.8 0.1 3.8 3 1 0 3 3 3 0 Thioredoxin-like domain F-box PF00646.33 EAK89982.1 - 0.00014 21.6 0.2 0.00036 20.3 0.2 1.7 1 0 0 1 1 1 1 F-box domain Ank_2 PF12796.7 EAK89983.1 - 3.5e-14 53.1 0.9 5.5e-06 26.9 0.0 4.8 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK89983.1 - 5.9e-13 49.0 2.4 0.00011 22.7 0.2 5.7 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EAK89983.1 - 6.5e-07 29.5 0.7 0.0034 17.7 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAK89983.1 - 1.5e-06 28.1 1.4 15 6.6 0.0 6.5 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EAK89983.1 - 5.6e-06 26.6 1.6 4.7 7.8 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat NCBP3 PF10309.9 EAK89984.1 - 0.0069 16.2 0.3 0.017 15.0 0.3 1.7 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 DUF3657 PF12394.8 EAK89984.1 - 0.027 15.0 0.4 0.027 15.0 0.4 2.0 2 0 0 2 2 2 0 Protein FAM135 Baculo_PEP_C PF04513.12 EAK89984.1 - 0.046 13.8 1.5 0.88 9.6 0.2 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PP_kinase_N PF13089.6 EAK89984.1 - 0.057 13.8 2.0 0.15 12.4 0.1 2.4 2 1 1 3 3 3 0 Polyphosphate kinase N-terminal domain PUB PF09409.10 EAK89985.1 - 1.7e-13 50.3 0.5 4.5e-13 48.9 0.5 1.7 1 0 0 1 1 1 1 PUB domain Qua1 PF16274.5 EAK89985.1 - 2.7 7.9 7.3 6.4 6.7 2.6 3.1 2 0 0 2 2 2 0 Qua1 domain COMPASS-Shg1 PF05205.12 EAK89985.1 - 5.7 7.7 8.9 1.8 9.3 0.6 3.0 3 0 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 PAN_4 PF14295.6 EAK89986.1 - 0.0011 18.8 0.0 0.0035 17.2 0.0 1.9 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 EAK89986.1 - 0.0015 18.4 0.0 0.0073 16.2 0.0 2.2 1 0 0 1 1 1 1 PAN domain Phage_TAC_9 PF10876.8 EAK89986.1 - 0.042 13.9 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 Phage tail assemb.y chaperone protein, TAC GYF PF02213.16 EAK89987.1 - 0.043 13.5 1.8 0.046 13.4 0.2 1.9 2 0 0 2 2 2 0 GYF domain DUF5461 PF17545.2 EAK89987.1 - 0.078 13.3 0.2 0.61 10.4 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5461) GYF_2 PF14237.6 EAK89987.1 - 0.099 12.5 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 GYF domain 2 Gp_dh_C PF02800.20 EAK89989.1 - 3.8e-66 221.5 0.0 5.3e-66 221.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EAK89989.1 - 9.7e-40 135.0 0.0 2.1e-39 133.9 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EAK89989.1 - 0.08 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Hexokinase_1 PF00349.21 EAK89990.1 - 1.7e-55 188.0 0.7 5e-55 186.5 0.1 1.9 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.16 EAK89990.1 - 1.5e-52 178.4 0.0 2.3e-52 177.8 0.0 1.3 1 0 0 1 1 1 1 Hexokinase NUDIX_2 PF13869.6 EAK89991.1 - 6.2e-57 192.2 0.0 8.1e-57 191.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase Asp PF00026.23 EAK89992.1 - 1.7e-69 234.6 0.0 3.2e-69 233.8 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EAK89992.1 - 1.9e-12 47.8 0.1 2.7e-09 37.5 0.1 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EAK89992.1 - 0.0026 18.4 0.0 5.5 7.7 0.0 2.8 2 1 0 2 2 2 2 Aspartyl protease Ribosomal_L7Ae PF01248.26 EAK89993.1 - 1.2e-24 85.9 0.2 1.5e-24 85.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EAK89993.1 - 0.029 14.3 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 PELOTA RNA binding domain SET PF00856.28 EAK89994.1 - 0.00066 20.1 0.1 0.0021 18.5 0.1 1.9 1 1 0 1 1 1 1 SET domain Lipoprotein_7 PF01540.16 EAK89994.1 - 0.018 14.3 1.8 0.045 13.0 0.5 2.0 2 0 0 2 2 2 0 Adhesin lipoprotein Mito_carr PF00153.27 EAK89997.1 - 9.5e-38 128.0 1.2 4e-14 52.3 0.0 3.6 2 1 1 3 3 3 3 Mitochondrial carrier protein PH PF00169.29 EAK89998.1 - 6.6e-07 29.8 1.7 2.7e-06 27.8 1.7 2.1 1 0 0 1 1 1 1 PH domain Vps54 PF07928.12 EAK90001.1 - 0.00017 22.1 0.1 0.00017 22.1 0.1 3.5 5 0 0 5 5 5 1 Vps54-like protein AlphaC_C PF17480.2 EAK90001.1 - 0.048 13.7 2.3 0.42 10.7 2.3 2.7 1 0 0 1 1 1 0 AlphaC C-terminal Glutaredoxin PF00462.24 EAK90002.1 - 1.1e-13 51.1 0.0 2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin ZinT PF09223.11 EAK90002.1 - 0.035 14.0 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 ZinT (YodA) periplasmic lipocalin-like zinc-recruitment DUF1666 PF07891.12 EAK90003.1 - 0.25 11.0 11.9 0.24 11.0 11.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1666) V_ATPase_I PF01496.19 EAK90006.1 - 0.1 10.5 0.5 0.16 9.9 0.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cullin PF00888.22 EAK90007.1 - 2e-20 73.0 26.4 1.4e-17 63.6 26.4 4.1 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EAK90007.1 - 0.0081 16.2 3.6 0.04 13.9 3.6 2.3 1 0 0 1 1 1 1 Cullin protein neddylation domain TrmB PF01978.19 EAK90007.1 - 0.039 13.8 0.0 0.094 12.6 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PIG-H PF10181.9 EAK90007.1 - 0.086 12.7 0.5 0.76 9.7 0.0 2.7 3 0 0 3 3 3 0 GPI-GlcNAc transferase complex, PIG-H component TMEM208_SND2 PF05620.11 EAK90009.1 - 4.4e-13 49.3 14.1 1.9e-10 40.7 14.1 2.0 1 1 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 NT-C2 PF10358.9 EAK90010.1 - 1.1e-18 67.3 0.6 4.9e-18 65.2 0.0 2.4 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins FlxA PF14282.6 EAK90010.1 - 0.094 12.7 0.3 0.094 12.7 0.3 5.1 6 0 0 6 6 6 0 FlxA-like protein DUF1640 PF07798.11 EAK90010.1 - 0.15 12.1 0.1 0.15 12.1 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1640) FliD_N PF02465.18 EAK90010.1 - 0.58 10.9 0.1 0.58 10.9 0.1 4.8 4 1 0 4 4 4 0 Flagellar hook-associated protein 2 N-terminus Alph_Pro_TM PF09608.10 EAK90010.1 - 3.4 7.4 4.8 0.95 9.2 0.6 2.2 4 0 0 4 4 4 0 Putative transmembrane protein (Alph_Pro_TM) Hydrolase_4 PF12146.8 EAK90011.1 - 8.7e-17 61.2 0.0 1.7e-09 37.3 0.0 3.2 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK90011.1 - 4.6e-06 26.5 0.2 9.5e-05 22.2 0.1 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EAK90011.1 - 0.00015 22.5 0.0 0.00044 20.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EAK90011.1 - 0.029 14.2 1.6 9.7 5.9 0.0 3.3 5 0 0 5 5 5 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EAK90011.1 - 0.034 14.0 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Methyltransf_12 PF08242.12 EAK90011.1 - 0.14 12.9 0.1 0.46 11.3 0.1 1.8 1 0 0 1 1 1 0 Methyltransferase domain DUF2018 PF09442.10 EAK90012.1 - 0.17 12.8 3.7 13 6.8 1.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF2018) Collagen PF01391.18 EAK90014.1 - 8.1e-05 22.3 11.5 8.1e-05 22.3 11.5 2.9 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) SID-1_RNA_chan PF13965.6 EAK90014.1 - 1.6 7.1 9.2 2.8 6.2 9.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 EAK90014.1 - 5.8 5.7 11.3 11 4.8 11.3 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2828 PF11443.8 EAK90014.1 - 6.2 4.8 24.7 12 3.8 24.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CIAPIN1 PF05093.13 EAK90016.1 - 5.8e-20 71.7 14.1 1.2e-18 67.4 14.1 2.3 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Ndc80_HEC PF03801.13 EAK90017.1 - 2.5e-27 95.4 0.0 8.6e-27 93.6 0.0 1.9 1 0 0 1 1 1 1 HEC/Ndc80p family Cluap1 PF10234.9 EAK90017.1 - 0.12 11.7 0.0 0.12 11.7 0.0 5.5 3 2 2 5 5 5 0 Clusterin-associated protein-1 DUF5601 PF18151.1 EAK90017.1 - 0.13 12.6 2.5 0.99 9.8 2.5 2.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) WD40 PF00400.32 EAK90018.1 - 2.6e-06 28.0 2.8 0.11 13.4 0.0 4.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Bromodomain PF00439.25 EAK90018.1 - 1.2e-05 25.3 0.3 5.4e-05 23.2 0.3 2.1 1 0 0 1 1 1 1 Bromodomain zf-HC5HC2H PF13771.6 EAK90018.1 - 4.9e-05 23.5 7.2 0.00017 21.7 5.4 2.6 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EAK90018.1 - 4.9e-05 23.5 1.1 0.00019 21.5 1.1 2.0 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-RING-like PF08746.11 EAK90018.1 - 1.4 9.3 5.0 5.8 7.3 5.0 2.1 1 0 0 1 1 1 0 RING-like domain EF-hand_1 PF00036.32 EAK90019.1 - 0.00015 21.0 0.0 0.02 14.4 0.0 3.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EAK90019.1 - 0.00059 20.2 1.1 0.077 13.5 0.0 3.2 1 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EAK90019.1 - 0.00089 19.0 0.0 0.026 14.4 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain DUF531 PF04407.12 EAK90020.1 - 0.13 12.3 0.1 0.43 10.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF531) Ribosomal_L16 PF00252.18 EAK90021.1 - 3.9e-42 143.4 0.1 5e-42 143.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Metallophos PF00149.28 EAK90022.1 - 2.8e-36 126.0 0.1 5.3e-36 125.0 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Syntaxin PF00804.25 EAK90022.1 - 0.017 14.8 0.5 0.49 10.0 0.1 2.1 2 0 0 2 2 2 0 Syntaxin Mo25 PF08569.11 EAK90023.1 - 4.9e-63 213.5 20.6 7e-63 213.0 19.7 1.7 1 1 0 1 1 1 1 Mo25-like ATP_bind_1 PF03029.17 EAK90025.1 - 6.1e-81 271.7 0.1 6.9e-81 271.6 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EAK90025.1 - 0.00056 20.5 0.2 0.0017 18.9 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EAK90025.1 - 0.016 15.0 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EAK90025.1 - 0.016 15.2 0.0 0.14 12.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EAK90025.1 - 0.027 14.2 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EAK90025.1 - 0.033 14.0 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EAK90025.1 - 0.047 14.1 0.1 0.24 11.8 0.1 2.1 2 1 1 3 3 3 0 AAA ATPase domain AAA_17 PF13207.6 EAK90025.1 - 0.05 14.0 0.2 0.1 13.1 0.2 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EAK90025.1 - 0.1 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 EAK90025.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EAK90025.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.3 1 1 0 1 1 1 0 AAA domain CS PF04969.16 EAK90026.1 - 3.5e-05 24.7 2.8 3.5e-05 24.7 2.8 2.2 2 1 0 2 2 2 1 CS domain CDC37_N PF03234.14 EAK90026.1 - 0.0011 19.8 1.5 0.0011 19.8 1.5 2.4 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding Zn_Tnp_IS1595 PF12760.7 EAK90027.1 - 0.51 10.4 2.4 1.1 9.3 2.4 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain APG6_N PF17675.1 EAK90029.1 - 0.0019 18.7 21.4 0.0019 18.7 21.4 4.3 2 1 2 4 4 4 2 Apg6 coiled-coil region GAS PF13851.6 EAK90029.1 - 1.1 8.6 60.5 0.47 9.8 15.8 4.7 3 2 1 4 4 4 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EAK90029.1 - 3.4 7.8 52.0 0.54 10.4 7.5 4.2 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) TRAPPC-Trs85 PF12739.7 EAK90030.1 - 1.1e-25 90.5 0.6 7.6e-25 87.7 0.4 2.2 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit His_Phos_1 PF00300.22 EAK90031.1 - 9.4e-18 64.6 0.0 3.9e-10 39.7 0.0 3.5 2 2 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA PF00004.29 EAK90032.1 - 4.4e-40 137.2 0.0 9.5e-40 136.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAK90032.1 - 4.6e-10 39.1 0.1 9.8e-10 38.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EAK90032.1 - 2.8e-05 24.2 0.1 0.00012 22.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EAK90032.1 - 3.6e-05 24.1 0.2 0.0095 16.2 0.0 2.6 2 1 1 3 3 2 1 AAA domain AAA_16 PF13191.6 EAK90032.1 - 9.8e-05 22.8 0.2 0.0036 17.7 0.1 2.3 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EAK90032.1 - 0.00065 19.5 0.0 0.0021 17.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EAK90032.1 - 0.00094 19.3 0.0 0.0035 17.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EAK90032.1 - 0.0058 16.2 0.0 0.021 14.3 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 EAK90032.1 - 0.0065 17.0 0.0 0.029 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain BLOC1_2 PF10046.9 EAK90032.1 - 0.0098 16.2 0.0 0.091 13.1 0.0 2.6 3 0 0 3 3 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF815 PF05673.13 EAK90032.1 - 0.012 14.8 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 EAK90032.1 - 0.017 15.4 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EAK90032.1 - 0.022 14.5 0.1 0.1 12.3 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EAK90032.1 - 0.027 14.6 0.0 0.053 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EAK90032.1 - 0.047 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EAK90032.1 - 0.048 13.0 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EAK90032.1 - 0.064 12.5 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 EAK90032.1 - 0.087 12.7 0.0 11 5.9 0.0 2.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea zf_Rg PF17915.1 EAK90032.1 - 0.091 12.2 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 Reverse gyrase zinc finger IstB_IS21 PF01695.17 EAK90032.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein MARVEL PF01284.23 EAK90033.1 - 0.005 16.9 9.4 0.005 16.9 9.4 2.2 2 1 0 2 2 2 1 Membrane-associating domain Rax2 PF12768.7 EAK90033.1 - 0.039 13.4 0.1 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Adeno_E3_CR2 PF02439.15 EAK90033.1 - 0.19 11.5 0.0 0.19 11.5 0.0 3.0 3 0 0 3 3 3 0 Adenovirus E3 region protein CR2 Acyl_transf_3 PF01757.22 EAK90033.1 - 0.2 10.7 16.7 1 8.3 16.7 1.9 1 1 0 1 1 1 0 Acyltransferase family DUF202 PF02656.15 EAK90033.1 - 2.3 8.7 9.7 0.15 12.5 1.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF202) PIG-P PF08510.12 EAK90033.1 - 4.1 7.3 8.6 2.2 8.2 1.6 2.4 2 0 0 2 2 2 0 PIG-P YrhC PF14143.6 EAK90033.1 - 7.6 6.7 8.6 5.3 7.2 0.1 3.4 3 1 0 3 3 3 0 YrhC-like protein RRM_1 PF00076.22 EAK90034.1 - 1.1e-10 41.2 0.0 2.6e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF637 PF04830.13 EAK90034.1 - 0.092 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Possible hemagglutinin (DUF637) EF-hand_13 PF17958.1 EAK90035.1 - 0.1 12.4 0.1 0.5 10.2 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain Sp38 PF07354.12 EAK90036.1 - 0.019 14.4 0.3 0.37 10.2 0.1 2.3 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) GST_C_3 PF14497.6 EAK90036.1 - 0.046 13.9 1.1 1.8 8.8 0.0 2.9 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF4637 PF15470.6 EAK90036.1 - 0.053 13.3 0.6 0.11 12.2 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DNA_pol_B PF00136.21 EAK90037.1 - 6.6e-134 447.1 0.7 9.1e-134 446.6 0.7 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EAK90037.1 - 5.7e-65 219.7 0.4 9.4e-65 219.0 0.4 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EAK90037.1 - 1.3e-15 57.6 12.0 3.3e-15 56.3 12.0 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EAK90037.1 - 0.0018 17.2 0.1 0.0036 16.2 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral zf-RING-like PF08746.11 EAK90037.1 - 0.55 10.6 12.2 2.5 8.5 1.1 3.4 3 0 0 3 3 3 0 RING-like domain Helicase_C PF00271.31 EAK90038.1 - 2e-20 73.2 0.0 6.8e-18 65.0 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EAK90038.1 - 9.9e-17 61.2 0.0 3e-16 59.7 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EAK90038.1 - 8.4e-14 52.1 1.7 8.4e-14 52.1 1.7 3.1 3 0 0 3 3 3 1 RecQ zinc-binding HRDC PF00570.23 EAK90038.1 - 1.6e-06 28.0 0.0 3.9e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 HRDC domain SecA_DEAD PF07517.14 EAK90038.1 - 0.043 13.1 0.0 0.086 12.1 0.0 1.5 1 0 0 1 1 1 0 SecA DEAD-like domain Terminase_4 PF05119.12 EAK90038.1 - 0.51 10.8 2.6 44 4.6 0.1 3.5 3 0 0 3 3 3 0 Phage terminase, small subunit DUF4302 PF14135.6 EAK90039.1 - 0.69 9.8 7.4 0.64 9.9 0.9 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4302) DUF5344 PF17279.2 EAK90039.1 - 5.5 7.6 13.0 1.1 9.8 3.7 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5344) DUF1684 PF07920.11 EAK90040.1 - 0.1 12.9 0.4 0.19 12.0 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1684) HCO3_cotransp PF00955.21 EAK90040.1 - 1.4 7.6 3.4 0.34 9.7 0.1 1.5 2 0 0 2 2 2 0 HCO3- transporter family Myb_DNA-binding PF00249.31 EAK90042.1 - 1.2e-07 31.8 0.2 2.8e-07 30.6 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EAK90042.1 - 8.1e-05 22.8 0.1 0.00022 21.4 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain PRA1 PF03208.19 EAK90043.1 - 0.57 9.8 12.7 1.8 8.2 12.7 1.7 1 0 0 1 1 1 0 PRA1 family protein Svf1_C PF17187.4 EAK90045.1 - 0.03 14.1 1.8 0.09 12.6 1.8 1.8 1 0 0 1 1 1 0 Svf1-like C-terminal lipocalin-like domain UCH PF00443.29 EAK90046.1 - 3.7e-40 138.0 14.5 8.9e-40 136.8 14.5 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK90046.1 - 3e-16 59.9 9.5 5.7e-15 55.7 9.5 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EAK90046.1 - 4e-13 48.9 0.0 1.2e-12 47.4 0.0 1.9 1 0 0 1 1 1 1 Variant UBP zinc finger zf-UBP PF02148.19 EAK90046.1 - 5.6e-11 42.6 0.1 2.8e-10 40.4 0.0 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EAK90046.1 - 0.00011 22.0 0.0 0.39 10.7 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain UBA_4 PF14555.6 EAK90046.1 - 0.0012 18.6 0.9 0.0024 17.6 0.0 2.0 2 0 0 2 2 2 1 UBA-like domain Hormone_recep PF00104.30 EAK90046.1 - 0.023 14.3 1.3 0.07 12.7 0.7 2.1 2 0 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor RecX PF02631.16 EAK90046.1 - 0.046 14.2 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 RecX family DHHC PF01529.20 EAK90047.1 - 1.5e-35 122.2 4.0 1.5e-35 122.2 4.0 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase Gln-synt_C PF00120.24 EAK90048.1 - 1.9e-104 349.4 0.0 2.2e-104 349.2 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EAK90048.1 - 1.4e-20 72.8 0.6 2.8e-20 71.8 0.6 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain RNA_pol_Rpc34 PF05158.12 EAK90049.1 - 5.6e-42 144.3 2.3 4.3e-38 131.5 0.2 2.2 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.12 EAK90049.1 - 0.099 12.8 0.0 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC PIG-H PF10181.9 EAK90050.1 - 5.4e-08 32.6 0.8 2.4e-07 30.5 0.2 2.0 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component Phage_holin_2_3 PF16080.5 EAK90050.1 - 0.059 13.1 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Bacteriophage holin family HP1 Ribosomal_S8e PF01201.22 EAK90051.1 - 5.5e-52 175.6 0.2 6.7e-52 175.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e DUF3449 PF11931.8 EAK90054.1 - 4.7e-64 215.6 0.4 8.1e-64 214.8 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EAK90054.1 - 1.4e-14 54.3 3.9 1.4e-14 54.3 3.9 2.5 2 1 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 EAK90054.1 - 0.0089 16.4 4.7 1.3 9.5 0.3 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type YabA PF06156.13 EAK90054.1 - 0.095 13.4 1.8 0.35 11.5 1.8 2.0 1 0 0 1 1 1 0 Initiation control protein YabA DUF3752 PF12572.8 EAK90054.1 - 0.16 12.5 2.6 0.32 11.5 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) zf-C2H2_jaz PF12171.8 EAK90054.1 - 1.8 9.0 6.2 20 5.6 0.6 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EAK90054.1 - 5.1 8.2 5.2 11 7.1 1.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Rft-1 PF04506.13 EAK90055.1 - 1.3e-51 175.9 34.1 1.6e-51 175.6 34.1 1.0 1 0 0 1 1 1 1 Rft protein SAC3_GANP PF03399.16 EAK90056.1 - 5.4e-19 68.7 13.7 1.7e-18 67.0 6.1 3.3 2 2 0 2 2 2 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EAK90056.1 - 0.00011 22.1 0.4 0.0003 20.8 0.1 1.9 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family RRM_1 PF00076.22 EAK90057.1 - 4.6e-67 221.8 4.3 5.5e-15 54.9 0.0 5.8 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAK90057.1 - 3.5e-07 29.9 0.1 2.2 7.9 0.1 4.8 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EAK90057.1 - 5.7e-05 23.3 0.3 0.12 12.6 0.0 4.3 4 0 0 4 4 4 1 BRCA1-associated protein 2 Limkain-b1 PF11608.8 EAK90057.1 - 0.0013 18.7 0.5 3.3 7.8 0.0 4.1 3 0 0 3 3 3 1 Limkain b1 RRM_7 PF16367.5 EAK90057.1 - 0.0015 18.6 1.4 2.6 8.2 0.0 4.7 5 0 0 5 5 5 1 RNA recognition motif RL PF17797.1 EAK90057.1 - 0.0033 17.3 0.2 11 6.1 0.0 4.1 4 0 0 4 4 4 1 RL domain RRM_occluded PF16842.5 EAK90057.1 - 0.0043 16.9 1.5 0.012 15.4 0.0 2.7 4 0 0 4 4 4 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EAK90057.1 - 0.014 15.4 0.0 22 5.2 0.0 3.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif SNARE_assoc PF09335.11 EAK90058.1 - 2.4e-13 50.6 5.8 2.4e-13 50.6 5.8 2.1 2 1 0 2 2 2 1 SNARE associated Golgi protein DUF1980 PF09323.10 EAK90058.1 - 0.12 12.2 11.4 0.088 12.7 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) HEAT PF02985.22 EAK90059.1 - 1.8e-14 52.6 5.0 0.23 11.8 0.0 10.5 10 0 0 10 10 10 3 HEAT repeat HEAT_2 PF13646.6 EAK90059.1 - 4.6e-13 49.4 0.9 0.95 9.9 0.0 7.8 3 3 5 8 8 8 5 HEAT repeats SF3b1 PF08920.10 EAK90059.1 - 4.3e-11 43.4 4.1 3e-10 40.6 4.1 2.4 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT_EZ PF13513.6 EAK90059.1 - 6e-08 33.0 0.3 0.18 12.4 0.0 6.7 10 1 0 10 10 7 2 HEAT-like repeat Cnd1 PF12717.7 EAK90059.1 - 1.3e-07 31.8 0.5 2.2 8.3 0.0 6.0 4 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EAK90059.1 - 1.4e-06 28.1 3.1 0.021 14.4 0.1 4.2 4 1 1 5 5 5 2 CLASP N terminal UME PF08064.13 EAK90059.1 - 3.1e-06 27.0 0.4 0.37 10.7 0.0 5.4 3 2 2 5 5 5 1 UME (NUC010) domain Vac14_Fab1_bd PF12755.7 EAK90059.1 - 3.4e-06 27.6 0.1 0.17 12.5 0.0 4.5 4 2 0 4 4 4 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EAK90059.1 - 7e-05 22.8 11.2 0.069 13.1 0.0 5.5 6 2 0 6 6 6 2 Domain of unknown function (DUF3385) Dopey_N PF04118.14 EAK90059.1 - 0.00024 20.3 4.8 5.3 6.1 0.1 4.9 3 1 1 5 5 5 1 Dopey, N-terminal NUC173 PF08161.12 EAK90059.1 - 0.0031 17.2 0.2 8.6 6.0 0.0 4.2 4 1 0 4 4 4 2 NUC173 domain DUF4042 PF13251.6 EAK90059.1 - 0.0039 16.9 0.4 12 5.5 0.0 4.3 4 1 0 4 4 4 1 Domain of unknown function (DUF4042) Cnd3 PF12719.7 EAK90059.1 - 0.0059 15.8 0.2 0.0059 15.8 0.2 3.0 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain MMS19_C PF12460.8 EAK90059.1 - 0.0096 15.1 3.7 0.25 10.4 0.0 4.6 7 0 0 7 7 7 1 RNAPII transcription regulator C-terminal SNARE_assoc PF09335.11 EAK90060.1 - 9.4e-06 26.1 1.5 9.4e-06 26.1 1.5 2.4 2 1 1 3 3 3 1 SNARE associated Golgi protein PAP2 PF01569.21 EAK90060.1 - 0.28 11.0 0.0 0.28 11.0 0.0 3.5 3 1 0 4 4 4 0 PAP2 superfamily PRIMA1 PF16101.5 EAK90060.1 - 0.56 10.3 2.2 2.8 8.0 0.1 2.7 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Macoilin PF09726.9 EAK90060.1 - 4.4 5.7 6.8 6.4 5.2 6.8 1.1 1 0 0 1 1 1 0 Macoilin family Torus PF16131.5 EAK90061.1 - 3.4e-32 111.4 0.4 9e-32 110.0 0.4 1.7 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 EAK90061.1 - 1.3e-05 24.9 0.1 4.1e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EAK90061.1 - 0.00027 20.9 5.0 0.00066 19.6 5.0 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EAK90061.1 - 0.0052 16.6 5.1 0.014 15.2 5.1 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EAK90061.1 - 0.62 10.0 4.4 1.4 8.9 4.4 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ACAS_N PF16177.5 EAK90064.1 - 0.09 12.7 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Peptidase_S8 PF00082.22 EAK90066.1 - 2.5e-47 161.6 1.7 4.6e-47 160.7 1.7 1.4 1 0 0 1 1 1 1 Subtilase family Peptidase_C1 PF00112.23 EAK90067.1 - 9.8e-69 231.8 2.2 1.8e-68 230.9 2.2 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EAK90067.1 - 8.4e-13 48.6 10.4 1.1e-12 48.2 9.2 1.9 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EAK90067.1 - 1.2e-10 40.8 1.0 1.3e-06 27.5 0.1 2.4 2 0 0 2 2 2 2 Peptidase C1-like family 6PF2K PF01591.18 EAK90067.1 - 0.0058 16.0 3.1 0.011 15.1 3.1 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Insulin_TMD PF17870.1 EAK90067.1 - 0.024 14.7 0.3 0.054 13.6 0.3 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4519 PF15012.6 EAK90067.1 - 1.4 9.1 4.0 0.64 10.2 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) CRT-like PF08627.10 EAK90068.1 - 5.1e-113 377.4 20.5 6.3e-113 377.1 20.5 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EAK90068.1 - 6.9e-05 22.2 22.2 0.00017 20.9 22.2 1.6 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EAK90068.1 - 0.00011 22.3 26.5 0.036 14.3 11.8 3.2 3 0 0 3 3 3 3 EamA-like transporter family SLC35F PF06027.12 EAK90068.1 - 0.066 12.7 10.3 0.031 13.8 6.3 2.1 2 0 0 2 2 2 0 Solute carrier family 35 zf-CCCH_2 PF14608.6 EAK90069.1 - 0.061 13.8 17.5 0.066 13.7 3.2 4.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 EAK90069.1 - 0.32 11.1 9.7 3.1 8.0 0.0 3.6 3 0 0 3 3 3 0 Zinc finger domain Adaptin_N PF01602.20 EAK90071.1 - 3.8e-37 128.0 18.9 2.9e-36 125.1 18.9 2.0 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EAK90071.1 - 8.5e-19 68.2 0.2 8.5e-19 68.2 0.2 3.3 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EAK90071.1 - 0.00031 20.8 0.1 0.00084 19.4 0.1 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 EAK90071.1 - 0.023 14.9 0.0 8.6 6.9 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat NdhO PF11910.8 EAK90071.1 - 0.2 11.9 0.9 1 9.5 0.0 2.6 3 0 0 3 3 3 0 Cyanobacterial and plant NDH-1 subunit O MEIOC PF15189.6 EAK90072.1 - 0.053 13.1 1.4 0.11 12.1 1.4 1.5 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC Cpn60_TCP1 PF00118.24 EAK90074.1 - 7.5e-82 275.5 1.1 1.4e-81 274.6 1.1 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family HEAT PF02985.22 EAK90076.1 - 1.6e-09 37.2 8.7 0.84 10.1 0.0 7.4 9 0 0 9 9 9 4 HEAT repeat Cnd1 PF12717.7 EAK90076.1 - 1.1e-06 28.7 0.5 1.1 9.3 0.3 4.7 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EAK90076.1 - 2.5e-06 27.8 0.0 0.89 10.0 0.0 5.3 6 0 0 6 6 6 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EAK90076.1 - 0.0039 17.8 0.3 0.21 12.2 0.2 3.4 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EAK90076.1 - 0.014 15.8 0.1 57 4.4 0.0 4.6 5 0 0 5 5 5 0 HEAT-like repeat Hydrolase_4 PF12146.8 EAK90077.1 - 3.6e-12 46.1 0.0 5.1e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAK90077.1 - 1.6e-07 31.3 0.0 8.1e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EAK90077.1 - 2e-07 30.7 0.0 1.2e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EAK90077.1 - 1.2e-06 29.3 0.0 0.00033 21.3 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family FSH1 PF03959.13 EAK90077.1 - 4.4e-05 23.3 0.0 6.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EAK90077.1 - 0.022 14.6 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.18 EAK90077.1 - 0.027 14.0 0.0 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EAK90077.1 - 0.059 13.2 0.0 6.7 6.5 0.1 2.7 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 EAK90077.1 - 0.11 12.0 0.0 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) CS PF04969.16 EAK90079.1 - 3.5e-05 24.7 0.4 8e-05 23.6 0.4 1.6 1 1 0 1 1 1 1 CS domain Ribophorin_I PF04597.14 EAK90081.1 - 2.3e-76 257.8 5.7 2.7e-76 257.6 5.7 1.0 1 0 0 1 1 1 1 Ribophorin I MNSV_P7B PF06692.11 EAK90081.1 - 0.11 12.5 1.3 2 8.5 0.2 2.9 2 1 1 3 3 3 0 Melon necrotic spot virus P7B protein Pkinase PF00069.25 EAK90082.1 - 5.4e-32 111.2 0.0 8.3e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90082.1 - 1.7e-13 50.5 0.0 2.8e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK90082.1 - 0.00062 19.2 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EAK90082.1 - 0.025 14.2 0.0 0.063 12.9 0.0 1.6 1 0 0 1 1 1 0 RIO1 family SGT1 PF07093.11 EAK90083.1 - 7e-25 87.5 25.9 2e-21 76.1 26.0 2.8 1 1 0 1 1 1 1 SGT1 protein Paramyx_P_V_C PF03210.13 EAK90083.1 - 0.12 12.2 0.8 0.4 10.5 0.0 2.1 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal Adaptin_binding PF10199.9 EAK90083.1 - 6.6 7.4 10.8 14 6.3 10.8 1.7 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Lectin_leg-like PF03388.13 EAK90085.1 - 3.7e-22 78.8 0.1 7.4e-22 77.8 0.1 1.5 1 1 0 1 1 1 1 Legume-like lectin family SNARE PF05739.19 EAK90085.1 - 2.4e-05 24.3 0.6 5.1e-05 23.2 0.6 1.6 1 0 0 1 1 1 1 SNARE domain Lectin_legB PF00139.19 EAK90085.1 - 0.00013 21.6 0.5 0.00038 20.1 0.5 1.8 1 1 0 1 1 1 1 Legume lectin domain Bact_lectin PF18483.1 EAK90085.1 - 0.0031 17.6 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial lectin Met_10 PF02475.16 EAK90086.1 - 2.6e-41 141.6 0.1 4.1e-41 140.9 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EAK90086.1 - 0.00037 20.1 0.0 0.00064 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EAK90086.1 - 0.0025 17.2 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EAK90086.1 - 0.012 16.3 0.0 0.024 15.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EAK90086.1 - 0.013 15.3 0.1 0.032 14.0 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EAK90086.1 - 0.048 13.6 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EAK90086.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DTC PF18102.1 EAK90087.1 - 2.5e-28 98.9 0.1 6.2e-28 97.6 0.1 1.7 1 0 0 1 1 1 1 Deltex C-terminal domain WWE PF02825.20 EAK90087.1 - 9.7e-12 45.3 14.6 8.9e-08 32.6 1.6 3.8 3 1 0 3 3 3 2 WWE domain zf-RING_2 PF13639.6 EAK90087.1 - 1.2e-07 31.9 7.9 1.2e-07 31.9 7.9 2.0 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 EAK90087.1 - 1.4e-05 24.7 4.8 4.7e-05 23.0 4.8 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EAK90087.1 - 6.5e-05 22.9 4.5 0.00043 20.2 4.9 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EAK90087.1 - 0.0006 20.0 4.9 0.0006 20.0 4.9 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EAK90087.1 - 0.0012 18.6 9.1 0.0012 18.6 9.1 2.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EAK90087.1 - 0.0013 18.5 1.8 0.0038 17.0 1.8 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.25 EAK90087.1 - 0.0024 17.7 9.5 0.0024 17.7 9.5 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EAK90087.1 - 0.018 14.6 5.5 0.018 14.6 5.5 2.1 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 EAK90087.1 - 0.021 14.7 5.9 0.059 13.3 5.9 1.8 1 0 0 1 1 1 0 PHD-finger SAICAR_synt PF01259.18 EAK90087.1 - 0.026 14.1 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 SAICAR synthetase zf-RING_6 PF14835.6 EAK90087.1 - 0.027 14.3 2.9 0.027 14.3 2.9 1.9 2 1 0 2 2 2 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 EAK90087.1 - 0.064 13.3 4.2 0.3 11.2 4.3 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EAK90087.1 - 5.1 7.1 14.4 0.096 12.7 7.1 2.0 2 0 0 2 2 1 0 zinc-RING finger domain PI3K_P85_iSH2 PF16454.5 EAK90088.1 - 3.8 7.1 10.6 0.17 11.5 3.9 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CAMSAP_CKK PF08683.11 EAK90089.1 - 1.4e-20 73.6 0.2 2.3e-20 72.9 0.2 1.3 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated zf-RING_9 PF13901.6 EAK90091.1 - 1.7e-11 44.5 8.3 1.1e-10 41.9 8.3 2.3 1 1 0 1 1 1 1 Putative zinc-RING and/or ribbon DUF2572 PF10833.8 EAK90092.1 - 0.03 14.1 0.8 0.03 14.1 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2572) TSC22 PF01166.18 EAK90092.1 - 1.6 9.1 5.9 1 9.7 0.8 3.0 2 2 2 4 4 4 0 TSC-22/dip/bun family Pkinase PF00069.25 EAK90093.1 - 1e-59 202.1 0.0 6e-59 199.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90093.1 - 2.3e-32 112.3 0.0 3.4e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK90093.1 - 5.7e-07 29.1 0.0 1.6e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EAK90093.1 - 0.00028 20.6 0.0 0.9 9.1 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EAK90093.1 - 0.0039 16.0 0.0 0.007 15.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EAK90093.1 - 0.0083 16.1 0.0 0.029 14.3 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EAK90093.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SH2_2 PF14633.6 EAK90094.1 - 9.8e-29 100.3 0.0 2.4e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 SH2 domain HHH_7 PF14635.6 EAK90094.1 - 3.9e-11 43.2 0.0 1.3e-10 41.6 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif SPT6_acidic PF14632.6 EAK90094.1 - 0.00019 21.9 20.2 0.00019 21.9 20.2 7.0 4 1 2 7 7 7 1 Acidic N-terminal SPT6 HTH_44 PF14641.6 EAK90094.1 - 0.0024 18.3 0.4 0.0078 16.6 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 ABC_tran PF00005.27 EAK90095.1 - 1.3e-46 158.6 0.1 9.7e-23 81.2 0.0 3.1 3 1 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EAK90095.1 - 3.3e-19 68.7 0.2 3.3e-19 68.7 0.2 2.3 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EAK90095.1 - 2.4e-15 57.1 17.1 3.3e-07 30.4 0.3 4.5 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EAK90095.1 - 1.4e-10 41.0 1.8 0.0054 16.2 0.0 3.7 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EAK90095.1 - 9.2e-05 22.1 5.7 0.094 12.5 0.2 3.6 4 0 0 4 4 4 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EAK90095.1 - 0.0001 22.6 0.2 0.096 13.0 0.2 3.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EAK90095.1 - 0.00019 21.8 0.0 0.37 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EAK90095.1 - 0.00023 21.1 0.0 0.79 9.6 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EAK90095.1 - 0.0019 18.0 0.1 0.86 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EAK90095.1 - 0.002 18.2 5.0 6.1 6.9 0.1 4.4 4 0 0 4 4 4 0 Helicase HerA, central domain G-alpha PF00503.20 EAK90095.1 - 0.0025 17.0 0.2 0.0098 15.1 0.0 2.1 2 1 0 2 2 2 1 G-protein alpha subunit AAA_28 PF13521.6 EAK90095.1 - 0.0032 17.7 2.0 1.3 9.3 0.6 2.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EAK90095.1 - 0.0038 17.6 0.2 0.064 13.6 0.0 2.7 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 EAK90095.1 - 0.0046 16.9 1.4 3.5 7.5 0.6 2.7 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.6 EAK90095.1 - 0.0049 16.6 0.0 0.0049 16.6 0.0 5.0 6 1 0 6 6 6 2 AAA ATPase domain T2SSE PF00437.20 EAK90095.1 - 0.005 15.9 2.3 0.013 14.6 0.3 2.4 2 1 0 3 3 3 1 Type II/IV secretion system protein Roc PF08477.13 EAK90095.1 - 0.0052 17.0 0.3 25 5.1 0.0 3.6 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EAK90095.1 - 0.0089 16.1 0.0 1.4 9.0 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EAK90095.1 - 0.011 16.3 0.0 0.011 16.3 0.0 4.6 4 1 1 5 5 4 0 AAA domain AAA_33 PF13671.6 EAK90095.1 - 0.013 15.7 0.1 2 8.6 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EAK90095.1 - 0.013 16.0 2.6 1.6 9.3 0.0 3.7 5 0 0 5 5 3 0 AAA domain NB-ARC PF00931.22 EAK90095.1 - 0.016 14.4 0.5 4.4 6.4 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 EAK90095.1 - 0.018 14.5 0.5 0.4 10.2 0.3 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EAK90095.1 - 0.019 15.4 0.1 8 6.9 0.0 2.8 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.23 EAK90095.1 - 0.019 15.0 0.1 5.9 6.9 0.0 2.7 2 1 0 2 2 2 0 Dynamin family NTPase_1 PF03266.15 EAK90095.1 - 0.023 14.6 0.9 1.9 8.4 0.3 2.8 2 0 0 2 2 2 0 NTPase AAA PF00004.29 EAK90095.1 - 0.056 13.9 0.2 4.8 7.6 0.0 3.6 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) OTCace PF00185.24 EAK90095.1 - 0.061 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain FtsK_SpoIIIE PF01580.18 EAK90095.1 - 0.1 11.9 0.9 0.27 10.6 0.1 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family MobB PF03205.14 EAK90095.1 - 0.14 12.1 0.1 4.2 7.3 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EAK90095.1 - 0.18 11.8 0.2 2.3 8.2 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EAK90095.1 - 0.21 11.2 0.7 1.2 8.8 0.1 2.4 3 0 0 3 3 3 0 Sigma-54 interaction domain cobW PF02492.19 EAK90095.1 - 0.32 10.6 1.4 11 5.6 0.4 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain Fe_hyd_SSU PF02256.17 EAK90096.1 - 0.1 12.7 1.1 6.1 7.0 0.1 2.3 2 0 0 2 2 2 0 Iron hydrogenase small subunit FYRC PF05965.14 EAK90099.1 - 0.01 16.0 0.0 2 8.7 0.0 3.0 2 0 0 2 2 2 0 F/Y rich C-terminus AP2 PF00847.20 EAK90101.1 - 4.8e-50 167.6 11.0 3e-14 53.0 1.3 4.4 4 0 0 4 4 4 4 AP2 domain ZapD PF07072.11 EAK90102.1 - 0.064 13.0 0.6 0.37 10.5 0.1 2.5 2 1 1 3 3 3 0 Cell division protein MaoC_dehydratas PF01575.19 EAK90103.1 - 0.1 12.1 0.0 0.76 9.4 0.0 2.4 3 0 0 3 3 3 0 MaoC like domain BRCT_3 PF18428.1 EAK90103.1 - 0.13 12.3 0.2 0.31 11.2 0.2 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF4003 PF13170.6 EAK90104.1 - 0.017 14.5 0.1 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) Sld3_N PF18523.1 EAK90104.1 - 0.82 9.8 4.4 5.8 7.1 0.5 3.1 2 1 1 3 3 3 0 Sld3 N-terminal domain Tox-HNH-HHH PF15637.6 EAK90105.1 - 1.7 8.8 7.7 3.9 7.7 0.1 3.9 4 0 0 4 4 4 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif EF-hand_3 PF09069.11 EAK90106.1 - 0.11 12.9 0.1 1.1 9.7 0.0 2.7 2 0 0 2 2 2 0 EF-hand DUF4731 PF15875.5 EAK90111.1 - 0.04 14.1 0.4 0.04 14.1 0.4 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4731) BRK PF07533.16 EAK90111.1 - 0.097 12.3 0.0 6 6.6 0.0 2.7 1 1 1 2 2 2 0 BRK domain DUF3273 PF11677.8 EAK90113.1 - 2.9e-71 239.9 11.5 3.4e-71 239.7 11.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) tRNA-synt_2c PF01411.19 EAK90114.1 - 8.8e-189 628.6 0.0 8.8e-189 628.6 0.0 1.9 3 0 0 3 3 3 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EAK90114.1 - 9.5e-16 57.6 2.4 1.4e-15 57.1 0.3 2.6 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EAK90114.1 - 6.1e-06 26.7 0.6 2.7e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 DHHA1 domain DUF3492 PF11997.8 EAK90114.1 - 0.004 16.9 2.3 4 7.1 0.1 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF3492) STAT_int PF02865.17 EAK90114.1 - 1.1 9.7 6.2 0.37 11.3 0.3 3.2 3 1 0 3 3 3 0 STAT protein, protein interaction domain OrfB_IS605 PF01385.19 EAK90114.1 - 2.7 8.2 6.2 0.6 10.3 1.1 2.4 2 1 0 2 2 2 0 Probable transposase Ribosomal_L14 PF00238.19 EAK90115.1 - 7.6e-34 116.4 0.0 9.4e-34 116.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e IML1 PF12257.8 EAK90116.1 - 1.1e-20 73.9 4.5 4.4e-20 72.0 4.5 2.0 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 zf_CopZ PF18423.1 EAK90116.1 - 0.097 12.6 0.6 0.39 10.7 0.1 2.4 2 0 0 2 2 2 0 Zinc binding domain Got1 PF04178.12 EAK90117.1 - 1e-27 96.8 18.9 1.7e-27 96.1 18.9 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2070 PF09843.9 EAK90117.1 - 3.7 5.7 14.4 4.2 5.5 14.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) bZIP_2 PF07716.15 EAK90118.1 - 0.00032 20.7 10.1 0.00032 20.7 10.1 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EAK90118.1 - 0.0042 17.1 8.1 0.014 15.5 8.1 1.9 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EAK90118.1 - 0.11 13.0 4.7 0.43 11.1 4.7 2.0 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF1003 PF06210.11 EAK90118.1 - 0.42 10.7 2.4 1 9.5 2.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Thioredoxin PF00085.20 EAK90119.1 - 3.8e-26 91.1 0.7 1.2e-25 89.5 0.7 1.9 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EAK90119.1 - 5.3e-06 26.0 4.6 0.0053 16.1 0.2 3.1 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EAK90119.1 - 0.00041 20.8 0.7 0.0012 19.3 0.2 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EAK90119.1 - 0.0028 18.0 0.5 0.019 15.3 0.1 2.6 1 1 1 2 2 2 1 Thioredoxin-like DnaJ PF00226.31 EAK90120.1 - 1.4e-17 63.5 0.2 5.4e-17 61.7 0.2 2.0 1 0 0 1 1 1 1 DnaJ domain FlaC_arch PF05377.11 EAK90120.1 - 0.23 11.9 1.8 2.3 8.7 1.1 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) TP_methylase PF00590.20 EAK90121.1 - 6.4e-22 78.5 0.0 1.4e-21 77.4 0.0 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Acyltransferase PF01553.21 EAK90122.1 - 6.4e-17 61.4 0.0 5.6e-16 58.4 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase zf-CCCH PF00642.24 EAK90123.1 - 1.7e-08 34.2 8.6 0.003 17.4 0.1 3.4 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EAK90123.1 - 9.5e-07 28.7 0.4 9.5e-07 28.7 0.4 4.0 3 2 1 4 4 4 1 Zinc finger domain Torus PF16131.5 EAK90123.1 - 1.4e-06 29.0 10.8 0.00043 21.0 0.7 3.4 2 1 2 4 4 4 2 Torus domain zf-CCCH_4 PF18044.1 EAK90123.1 - 4.7e-06 26.3 14.3 1.2e-05 25.0 0.2 3.6 3 1 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EAK90123.1 - 3.6e-05 24.1 6.0 0.3 11.6 0.0 3.7 3 1 0 3 3 3 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EAK90123.1 - 0.55 10.5 12.0 2.1 8.6 2.1 3.3 2 2 2 4 4 4 0 Zinc-finger containing family zf-C3H1 PF10650.9 EAK90123.1 - 6.8 6.5 10.5 1.3 8.8 0.2 4.1 4 0 0 4 4 4 0 Putative zinc-finger domain Hist_deacetyl PF00850.19 EAK90124.1 - 4.6e-77 259.5 0.1 5.6e-77 259.2 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain PS_pyruv_trans PF04230.13 EAK90125.1 - 6.1e-21 75.6 2.1 6.1e-21 75.6 2.1 1.8 2 0 0 2 2 2 1 Polysaccharide pyruvyl transferase Fringe PF02434.16 EAK90125.1 - 3e-19 69.4 0.1 6.8e-19 68.3 0.1 1.6 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EAK90125.1 - 1.1e-10 41.7 0.0 3.4e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 Galactosyltransferase Fez1 PF06818.15 EAK90126.1 - 0.00035 21.1 20.1 0.00035 21.1 20.1 4.2 2 1 2 4 4 4 1 Fez1 DUF572 PF04502.13 EAK90127.1 - 8e-49 167.1 6.4 1e-48 166.7 6.4 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) DNA_RNApol_7kD PF03604.13 EAK90127.1 - 0.89 9.3 3.6 0.8 9.4 0.1 2.4 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit BT1 PF03092.16 EAK90128.1 - 3.5e-39 134.4 14.5 8.3e-35 120.0 12.0 2.1 1 1 0 2 2 2 2 BT1 family MFS_1_like PF12832.7 EAK90128.1 - 0.00067 18.6 9.6 0.00067 18.6 9.6 1.7 1 1 1 2 2 2 1 MFS_1 like family DUF2367 PF10164.9 EAK90128.1 - 0.14 12.7 0.2 0.4 11.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) MIF4G PF02854.19 EAK90129.1 - 2.3e-29 102.5 8.4 2.3e-29 102.5 8.4 2.1 2 0 0 2 2 2 1 MIF4G domain PAM2 PF07145.15 EAK90129.1 - 2.6e-08 33.0 0.0 4.7e-05 22.8 0.0 2.7 2 0 0 2 2 2 2 Ataxin-2 C-terminal region MA3 PF02847.17 EAK90129.1 - 0.085 12.8 1.4 0.17 11.9 0.1 2.2 2 0 0 2 2 2 0 MA3 domain Ets PF00178.22 EAK90129.1 - 0.13 12.8 0.6 0.54 10.8 0.6 2.1 1 0 0 1 1 1 0 Ets-domain CS PF04969.16 EAK90130.1 - 9.5e-10 39.4 0.1 1.9e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 CS domain Rtt102p PF09510.10 EAK90130.1 - 0.7 10.1 5.8 1.2 9.4 5.8 1.3 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein MMR_HSR1_C PF08438.10 EAK90131.1 - 2.7e-31 108.4 0.4 5.2e-31 107.5 0.4 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EAK90131.1 - 1.1e-19 70.5 0.0 3.4e-19 69.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAK90131.1 - 9.6e-10 38.2 0.1 8e-07 28.7 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EAK90131.1 - 0.00026 20.9 0.5 0.088 12.6 0.1 2.3 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Spore_IV_A PF09547.10 EAK90131.1 - 0.0043 16.0 2.5 0.1 11.5 0.8 2.1 2 0 0 2 2 2 2 Stage IV sporulation protein A (spore_IV_A) GTP_EFTU PF00009.27 EAK90131.1 - 0.029 13.9 0.1 0.35 10.4 0.1 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRP19 PF01922.17 EAK90132.1 - 1.6e-21 77.1 0.0 2.7e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 SRP19 protein Ribonuc_red_lgC PF02867.15 EAK90133.1 - 5.7e-188 625.7 0.0 7e-188 625.4 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EAK90133.1 - 2.9e-22 78.5 0.0 6e-22 77.5 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EAK90133.1 - 7e-13 49.0 0.0 1.8e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain Adaptin_N PF01602.20 EAK90134.1 - 2.6e-20 72.5 16.1 4.8e-13 48.5 0.1 5.2 4 1 0 5 5 5 4 Adaptin N terminal region Cbl_N PF02262.16 EAK90134.1 - 0.089 12.8 0.9 1.3 9.0 0.0 3.3 3 1 1 4 4 4 0 CBL proto-oncogene N-terminal domain 1 cEGF PF12662.7 EAK90135.1 - 1.1e-06 28.4 182.6 0.25 11.3 0.3 32.3 35 0 0 35 35 35 25 Complement Clr-like EGF-like GTP_EFTU PF00009.27 EAK90136.1 - 2.1e-31 109.0 0.0 2.1e-31 109.0 0.0 2.8 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EAK90136.1 - 2.1e-17 63.2 2.7 3.4e-17 62.5 0.1 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 EAK90136.1 - 2.8e-15 56.0 0.3 7.5e-15 54.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 EAK90136.1 - 2.9e-15 56.4 2.2 1.4e-09 38.1 0.2 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EAK90136.1 - 1.6e-06 28.2 3.6 6.1e-06 26.3 0.0 3.2 3 1 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EAK90136.1 - 0.00039 20.6 0.0 0.0017 18.5 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EAK90136.1 - 0.048 13.4 1.8 0.073 12.8 0.0 2.4 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein CdiA_C PF18451.1 EAK90136.1 - 0.15 12.3 2.2 0.34 11.2 0.5 2.5 2 0 0 2 2 2 0 Contact-dependent growth inhibition CdiA C-terminal domain Hydrolase PF00702.26 EAK90136.1 - 0.45 10.8 6.7 1.1 9.4 4.8 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase mRNA_cap_enzyme PF01331.19 EAK90137.1 - 8.4e-38 130.1 0.1 1.4e-24 87.0 0.0 2.2 2 0 0 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EAK90137.1 - 1.3e-14 54.8 0.0 3.4e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain RNA_ligase PF09414.10 EAK90137.1 - 0.0028 18.0 0.0 0.0044 17.3 0.0 1.4 1 0 0 1 1 1 1 RNA ligase CutA1 PF03091.15 EAK90138.1 - 3.5e-34 116.6 1.2 4.1e-34 116.4 1.2 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein NOT2_3_5 PF04153.18 EAK90139.1 - 8e-19 68.0 2.8 8e-19 68.0 2.8 2.6 3 1 0 3 3 3 1 NOT2 / NOT3 / NOT5 family LUC7 PF03194.15 EAK90140.1 - 5.8e-60 203.1 7.5 1.2e-59 202.1 7.5 1.5 1 0 0 1 1 1 1 LUC7 N_terminus Nnf1 PF03980.14 EAK90140.1 - 0.032 14.6 0.2 0.082 13.3 0.2 1.7 1 0 0 1 1 1 0 Nnf1 Rad10 PF03834.14 EAK90141.1 - 9.5e-37 125.5 0.0 1.4e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 PF12826.7 EAK90141.1 - 4.4e-09 36.3 0.0 9.6e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EAK90141.1 - 5.1e-08 33.4 0.1 1.1e-07 32.3 0.1 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 EAK90141.1 - 5.6e-06 26.0 0.1 1.4e-05 24.7 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.7 EAK90141.1 - 0.0047 17.2 0.1 0.071 13.4 0.1 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif DUF790 PF05626.11 EAK90141.1 - 0.0099 14.6 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF790) Acid_PPase PF12689.7 EAK90141.1 - 0.085 12.7 0.0 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 Acid Phosphatase Motile_Sperm PF00635.26 EAK90142.1 - 1.7e-23 82.5 0.0 3.7e-23 81.4 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain SOG2 PF10428.9 EAK90142.1 - 0.0012 18.1 1.3 0.0016 17.8 1.3 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein CENP-Q PF13094.6 EAK90142.1 - 0.033 14.4 0.1 0.055 13.7 0.1 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HALZ PF02183.18 EAK90142.1 - 0.043 14.0 3.6 0.083 13.1 3.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper EMP24_GP25L PF01105.24 EAK90142.1 - 0.045 13.7 0.3 0.063 13.2 0.3 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD FTA4 PF13093.6 EAK90142.1 - 0.088 12.7 0.7 0.11 12.4 0.7 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 TMCO5 PF14992.6 EAK90142.1 - 0.15 11.6 3.6 0.33 10.5 3.3 1.7 1 1 1 2 2 2 0 TMCO5 family bZIP_1 PF00170.21 EAK90142.1 - 0.22 11.7 2.8 0.54 10.4 2.8 1.6 1 0 0 1 1 1 0 bZIP transcription factor Helicase_C_2 PF13307.6 EAK90143.1 - 1.3e-54 184.9 0.1 1.3e-53 181.7 0.0 2.6 2 1 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EAK90143.1 - 5.8e-41 140.0 4.6 3.1e-39 134.4 4.6 2.5 1 1 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EAK90143.1 - 1.5e-05 25.0 5.7 0.001 19.1 0.1 3.6 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EAK90143.1 - 3.3e-05 23.7 2.5 0.039 13.7 0.1 3.5 4 0 0 4 4 4 2 DEAD/DEAH box helicase AAA_22 PF13401.6 EAK90143.1 - 0.024 14.9 4.3 2.5 8.4 0.2 3.2 3 0 0 3 3 3 0 AAA domain Exog_C PF18026.1 EAK90143.1 - 0.029 14.4 0.0 0.082 13.0 0.0 1.7 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain RRM_1 PF00076.22 EAK90144.1 - 8.4e-15 54.4 0.0 1.5e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) S6PP PF05116.13 EAK90145.1 - 1.9e-35 122.6 0.0 1.6e-18 67.2 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 EAK90145.1 - 7.4e-14 52.1 0.0 5.3e-13 49.3 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase COG7 PF10191.9 EAK90146.1 - 6.4e-06 24.7 1.7 6.4e-06 24.7 1.7 2.7 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) DUF1033 PF06279.11 EAK90146.1 - 0.035 14.3 0.9 0.12 12.5 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1033) RNase_H PF00075.24 EAK90146.1 - 0.12 12.6 1.6 1.7 8.8 0.1 3.0 1 1 1 2 2 2 0 RNase H Syntaxin-18_N PF10496.9 EAK90146.1 - 1.5 9.1 8.6 0.45 10.8 1.8 3.4 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus Pilin_PilX PF11530.8 EAK90146.1 - 6 6.8 6.7 6 6.8 0.8 2.7 2 0 0 2 2 2 0 Minor type IV pilin, PilX Ribosomal_S19 PF00203.21 EAK90148.1 - 2.9e-31 107.2 0.4 6.2e-31 106.1 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S19 Tai4 PF16695.5 EAK90149.1 - 0.019 15.5 2.2 0.033 14.7 0.3 2.3 2 0 0 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein Curto_V2 PF07325.11 EAK90149.1 - 1 9.2 15.9 0.13 12.1 6.3 3.3 2 1 1 3 3 3 0 Curtovirus V2 protein zf-CCCH PF00642.24 EAK90150.1 - 6e-09 35.6 4.3 6e-09 35.6 4.3 2.4 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EAK90150.1 - 9.7e-06 25.4 6.5 1.7e-05 24.6 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 EAK90150.1 - 2.5e-05 24.1 4.3 2.5e-05 24.1 4.3 2.5 2 0 0 2 2 2 1 Zinc finger domain zf-RING_2 PF13639.6 EAK90150.1 - 3.4e-05 24.1 10.1 8e-05 22.9 10.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EAK90150.1 - 4.1e-05 23.4 12.0 8.4e-05 22.5 12.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EAK90150.1 - 0.0011 18.9 9.8 0.0029 17.6 9.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EAK90150.1 - 0.0014 18.4 12.3 0.0014 18.4 12.3 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 EAK90150.1 - 0.002 17.9 2.8 0.002 17.9 2.8 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger zf-C3HC4_2 PF13923.6 EAK90150.1 - 0.0063 16.3 10.5 0.0063 16.3 10.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 EAK90150.1 - 0.016 15.4 5.9 0.016 15.4 5.9 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 EAK90150.1 - 0.056 13.2 3.0 0.12 12.2 3.0 1.6 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 EAK90150.1 - 0.2 11.5 7.6 0.47 10.4 7.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EAK90150.1 - 1.2 8.9 7.8 3.3 7.4 7.8 1.7 1 0 0 1 1 1 0 P-11 zinc finger DUF1272 PF06906.11 EAK90150.1 - 1.5 9.0 6.7 3.5 7.8 6.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-CCCH_2 PF14608.6 EAK90150.1 - 1.5 9.4 12.0 0.089 13.3 2.6 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DZR PF12773.7 EAK90150.1 - 1.6 8.8 9.1 3.4 7.8 9.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_4 PF15227.6 EAK90150.1 - 2.5 8.4 8.6 6.1 7.1 8.6 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF202 PF02656.15 EAK90151.1 - 5e-15 55.7 1.2 1.2e-14 54.5 1.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 EAK90151.1 - 1.4e-10 41.6 35.9 8.7e-08 32.5 0.5 4.9 2 2 2 4 4 4 3 SPX domain DUF4199 PF13858.6 EAK90151.1 - 0.014 15.8 0.4 0.014 15.8 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) 7TM_GPCR_Srj PF10319.9 EAK90151.1 - 0.087 12.2 2.5 0.1 12.0 0.4 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srj eRF1_2 PF03464.15 EAK90152.1 - 7.4e-45 152.5 0.0 1.5e-44 151.5 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EAK90152.1 - 5.5e-40 136.4 0.1 1.3e-39 135.2 0.1 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EAK90152.1 - 8.3e-21 74.3 0.0 1.4e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EAK90152.1 - 6.6e-10 39.4 0.0 1.1e-09 38.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EAK90152.1 - 2.6e-09 37.4 0.0 4.1e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Ribosomal_L7Ae PF01248.26 EAK90152.1 - 0.003 17.2 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF5643 PF18705.1 EAK90152.1 - 0.057 13.4 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5643) RRM_1 PF00076.22 EAK90153.1 - 9e-11 41.4 0.0 1.5e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK90153.1 - 0.073 13.2 0.0 0.22 11.6 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif TrpBP PF02081.15 EAK90153.1 - 0.073 12.9 0.3 0.16 11.8 0.1 1.7 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein DUF3584 PF12128.8 EAK90154.1 - 0.00015 19.5 35.5 0.00056 17.6 35.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3584) EzrA PF06160.12 EAK90154.1 - 0.22 9.7 44.6 5.7 5.0 23.7 2.5 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Rop-like PF05082.13 EAK90154.1 - 0.46 10.3 4.6 2.6 7.9 0.9 3.0 2 0 0 2 2 2 0 Rop-like Spc7 PF08317.11 EAK90154.1 - 1.2 8.0 41.8 0.56 9.0 20.9 2.8 1 1 0 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EAK90154.1 - 2.5 8.1 45.0 0.023 14.7 12.7 3.7 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YtxH PF12732.7 EAK90154.1 - 5 7.7 9.3 1.8e+03 -0.5 9.4 4.2 1 1 0 1 1 1 0 YtxH-like protein Golgin_A5 PF09787.9 EAK90154.1 - 8 5.8 44.1 4 6.8 11.8 2.7 1 1 1 2 2 2 0 Golgin subfamily A member 5 NPV_P10 PF05531.12 EAK90154.1 - 9.2 6.8 24.5 0.094 13.2 1.2 5.4 2 2 3 5 5 5 0 Nucleopolyhedrovirus P10 protein P5CR_dimer PF14748.6 EAK90155.1 - 1.2e-21 76.9 0.0 1.7e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EAK90155.1 - 9e-15 55.0 0.0 2.4e-14 53.7 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 EAK90155.1 - 0.051 14.4 0.0 0.09 13.6 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ribosomal_S30 PF04758.14 EAK90156.1 - 2.9e-27 94.6 9.8 3.2e-27 94.5 9.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Alpha-amylase PF00128.24 EAK90157.1 - 4.6e-15 56.0 0.2 3.3e-07 30.2 0.1 2.8 1 1 0 2 2 2 2 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 EAK90157.1 - 2.1e-05 24.9 0.5 6.8e-05 23.3 0.5 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EAK90157.1 - 0.023 15.0 0.2 0.14 12.5 0.0 2.3 2 0 0 2 2 2 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Malt_amylase_C PF16657.5 EAK90157.1 - 0.067 13.3 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain DUF3467 PF11950.8 EAK90157.1 - 0.12 12.6 0.1 0.36 11.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3467) DUF1639 PF07797.14 EAK90158.1 - 0.13 12.3 0.5 0.47 10.5 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) Trypan_PARP PF05887.11 EAK90160.1 - 0.0031 17.5 18.5 0.0031 17.5 18.5 3.5 2 1 1 3 3 3 1 Procyclic acidic repetitive protein (PARP) Merozoite_SPAM PF07133.11 EAK90160.1 - 0.0045 17.0 30.5 0.006 16.6 30.5 1.1 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) CDC45 PF02724.14 EAK90160.1 - 0.013 13.9 30.6 0.016 13.5 30.6 1.0 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.7 EAK90160.1 - 3 8.5 63.4 6.3 7.5 63.4 1.5 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Apt1 PF10351.9 EAK90160.1 - 5.5 5.7 14.1 6.6 5.5 14.1 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 EAK90160.1 - 6.1 6.8 10.9 8.2 6.4 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Nop14 PF04147.12 EAK90160.1 - 10 4.2 30.0 12 4.0 30.0 1.0 1 0 0 1 1 1 0 Nop14-like family UQ_con PF00179.26 EAK90161.1 - 1.2e-40 138.4 0.9 7.4e-35 119.6 0.3 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme RWD PF05773.22 EAK90161.1 - 0.0075 16.6 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EAK90161.1 - 0.0085 15.8 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B Glyco_transf_11 PF01531.16 EAK90161.1 - 0.045 13.0 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 11 RabGAP-TBC PF00566.18 EAK90162.1 - 3.5e-52 177.2 6.7 3.5e-52 177.2 6.7 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain LisH PF08513.11 EAK90162.1 - 0.14 12.2 0.2 0.67 10.0 0.0 2.3 2 0 0 2 2 2 0 LisH Ribosomal_S7 PF00177.21 EAK90163.1 - 1.8e-37 128.3 0.7 2.3e-37 127.9 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e ProRS-C_1 PF09180.11 EAK90164.1 - 9.1e-26 89.9 1.6 2.9e-25 88.2 1.3 2.1 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA_edit PF04073.15 EAK90164.1 - 5e-22 78.3 0.0 1e-21 77.3 0.0 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 EAK90164.1 - 6.7e-21 74.3 0.8 1.1e-19 70.4 0.2 3.0 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EAK90164.1 - 3.4e-18 66.3 0.0 9.9e-18 64.7 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) UME PF08064.13 EAK90165.1 - 0.00017 21.4 0.3 0.77 9.7 0.0 4.8 3 0 0 3 3 3 2 UME (NUC010) domain Cnd3 PF12719.7 EAK90165.1 - 0.0058 15.9 1.9 0.023 13.9 0.2 2.8 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Bac_RepA_C PF18008.1 EAK90165.1 - 0.11 12.9 0.7 1.4 9.3 0.1 2.8 2 0 0 2 2 2 0 Replication initiator protein A C-terminal domain Arm PF00514.23 EAK90165.1 - 0.14 12.2 19.9 9 6.5 0.3 9.9 12 0 0 12 12 12 0 Armadillo/beta-catenin-like repeat zf-Tim10_DDP PF02953.15 EAK90166.1 - 7.3e-14 51.2 0.5 1.2e-13 50.5 0.5 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Ank_4 PF13637.6 EAK90167.1 - 5.5e-41 138.4 0.9 1.5e-09 38.2 0.0 5.3 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAK90167.1 - 1.6e-35 121.6 0.2 5.2e-12 46.2 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EAK90167.1 - 1.1e-30 102.2 0.9 0.00018 21.6 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EAK90167.1 - 1.6e-30 104.2 0.7 2.9e-05 24.3 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 EAK90167.1 - 1.4e-28 98.6 1.2 3.1e-08 33.7 0.0 4.0 3 1 0 3 3 3 3 Ankyrin repeats (many copies) RNA_GG_bind PF10258.9 EAK90167.1 - 1.2e-23 83.0 0.4 2.6e-23 81.9 0.4 1.6 1 0 0 1 1 1 1 PHAX RNA-binding domain DUF3447 PF11929.8 EAK90167.1 - 0.0011 18.9 2.8 1.2 9.2 0.0 4.2 3 1 1 4 4 4 2 Domain of unknown function (DUF3447) RRM_1 PF00076.22 EAK90168.1 - 7.9e-37 124.9 0.9 1.3e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAK90168.1 - 1.5e-06 27.8 0.6 0.0068 16.0 0.1 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK90168.1 - 0.016 15.3 0.1 2.2 8.5 0.1 2.5 2 1 0 2 2 2 0 RNA recognition motif DUF4523 PF15023.6 EAK90168.1 - 0.046 13.5 0.0 0.52 10.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Myosin_head PF00063.21 EAK90169.1 - 9.1e-191 635.6 10.2 2.3e-190 634.2 10.2 1.7 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 EAK90169.1 - 6.9e-20 68.9 33.2 0.00019 20.9 1.0 6.8 6 0 0 6 6 6 6 IQ calmodulin-binding motif WD40 PF00400.32 EAK90169.1 - 1e-09 38.8 0.4 0.052 14.4 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat NACHT PF05729.12 EAK90169.1 - 0.014 15.3 1.1 0.8 9.6 0.0 3.2 3 0 0 3 3 3 0 NACHT domain Zeta_toxin PF06414.12 EAK90169.1 - 0.032 13.5 0.1 0.8 8.9 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 EAK90169.1 - 0.058 13.7 0.9 0.33 11.2 0.1 2.8 3 0 0 3 3 3 0 AAA domain Myosin_N PF02736.19 EAK90169.1 - 0.1 12.5 0.2 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain CENP-H PF05837.12 EAK90169.1 - 0.9 10.0 9.5 0.35 11.3 5.7 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Cep57_CLD_2 PF14197.6 EAK90169.1 - 1.9 8.6 11.8 6 7.0 10.5 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 APG6_N PF17675.1 EAK90169.1 - 2.5 8.6 13.8 12 6.5 13.8 2.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Spt5-NGN PF03439.13 EAK90170.1 - 2.2e-18 65.9 0.0 5.4e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EAK90170.1 - 1.7e-08 34.1 18.9 0.68 10.0 0.1 7.3 8 0 0 8 8 8 5 KOW motif Spt5_N PF11942.8 EAK90170.1 - 0.00059 20.8 10.6 0.0012 19.8 10.6 1.4 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal zf-B_box PF00643.24 EAK90171.1 - 4.8e-06 26.6 29.6 0.00058 20.0 8.5 3.2 3 0 0 3 3 3 2 B-box zinc finger TAP35_44 PF07265.11 EAK90171.1 - 0.023 14.7 0.1 0.092 12.8 0.1 2.1 1 0 0 1 1 1 0 Tapetum specific protein TAP35/TAP44 DEAD PF00270.29 EAK90172.1 - 1.3e-43 148.8 1.6 1.5e-43 148.6 0.0 1.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK90172.1 - 1.2e-27 96.4 0.1 3.5e-25 88.5 0.1 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EAK90172.1 - 0.27 11.5 2.8 1.4 9.2 1.7 2.7 2 1 0 2 2 2 0 AAA domain Prp19 PF08606.11 EAK90173.1 - 2.9e-29 100.9 0.5 5.8e-29 99.9 0.5 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 EAK90173.1 - 8.5e-06 25.9 0.1 0.0002 21.5 0.0 2.6 2 0 0 2 2 2 1 U-box domain WD40 PF00400.32 EAK90173.1 - 0.00054 20.7 1.8 0.015 16.1 0.2 3.3 2 0 0 2 2 2 1 WD domain, G-beta repeat zf-Nse PF11789.8 EAK90173.1 - 0.00084 19.1 0.3 0.0023 17.7 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 EAK90173.1 - 0.0053 16.9 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein ANAPC4_WD40 PF12894.7 EAK90173.1 - 0.018 15.3 0.1 2.4 8.5 0.0 3.4 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DEAD PF00270.29 EAK90174.1 - 5.4e-48 163.1 0.0 1e-47 162.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK90174.1 - 5.9e-27 94.2 0.2 1.6e-25 89.6 0.2 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain GUCT PF08152.12 EAK90174.1 - 1.8e-09 37.8 0.0 8.8e-09 35.5 0.0 2.2 2 0 0 2 2 2 1 GUCT (NUC152) domain ResIII PF04851.15 EAK90174.1 - 7.4e-08 32.6 0.0 1.6e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EAK90174.1 - 0.04 13.1 0.0 0.068 12.4 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase WD40 PF00400.32 EAK90175.1 - 9e-11 42.2 0.8 0.00015 22.5 0.0 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Cpn60_TCP1 PF00118.24 EAK90176.1 - 3.3e-146 487.8 3.9 3.8e-146 487.6 3.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.17 EAK90176.1 - 0.013 15.4 0.0 0.07 13.0 0.0 2.1 2 0 0 2 2 2 0 DAK2 domain DUF2529 PF10740.9 EAK90176.1 - 0.02 14.5 0.0 0.053 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) BRCT PF00533.26 EAK90176.1 - 0.15 12.4 0.1 2 8.9 0.0 2.5 1 1 1 2 2 2 0 BRCA1 C Terminus (BRCT) domain zf-HC5HC2H PF13771.6 EAK90177.1 - 2.7e-11 43.6 10.1 2.7e-11 43.6 10.1 3.1 2 1 1 3 3 3 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EAK90177.1 - 1.8e-10 40.9 25.4 1.9e-10 40.9 9.1 3.1 1 1 3 4 4 4 2 PHD-zinc-finger like domain PHD_2 PF13831.6 EAK90177.1 - 2e-06 27.3 4.3 2e-06 27.3 4.3 3.2 4 1 0 4 4 4 1 PHD-finger PHD PF00628.29 EAK90177.1 - 3e-05 23.8 6.0 3e-05 23.8 6.0 3.6 3 0 0 3 3 3 1 PHD-finger ABC2_membrane PF01061.24 EAK90178.1 - 6.5e-30 104.1 28.0 6.5e-30 104.1 28.0 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EAK90178.1 - 2.3e-23 83.2 0.0 3.5e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EAK90178.1 - 7.3e-08 32.6 6.0 0.00016 21.6 0.2 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EAK90178.1 - 9e-05 21.7 31.5 9e-05 21.7 31.5 2.0 1 1 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.19 EAK90178.1 - 0.00016 21.2 0.0 0.028 13.9 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EAK90178.1 - 0.0019 18.1 0.2 0.0037 17.2 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 EAK90178.1 - 0.0059 17.1 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EAK90178.1 - 0.0097 16.3 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EAK90178.1 - 0.026 14.2 0.3 6.8 6.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EAK90178.1 - 0.027 14.2 0.4 0.067 12.9 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EAK90178.1 - 0.05 13.3 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EAK90178.1 - 0.062 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EAK90178.1 - 0.09 12.7 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EAK90178.1 - 0.09 12.9 0.4 0.17 12.0 0.4 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EAK90178.1 - 0.11 13.0 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EAK90178.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EAK90178.1 - 0.21 10.6 0.3 0.41 9.7 0.3 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein TSP_1 PF00090.19 EAK90179.1 - 4.8e-16 58.7 31.4 1.3e-06 28.5 5.7 3.5 3 0 0 3 3 3 3 Thrombospondin type 1 domain EGF PF00008.27 EAK90179.1 - 4.3e-06 26.9 8.6 4.3e-06 26.9 8.6 3.0 4 0 0 4 4 4 1 EGF-like domain EGF_2 PF07974.13 EAK90179.1 - 1.2 9.6 20.1 0.18 12.2 13.5 3.0 1 1 1 2 2 2 0 EGF-like domain hEGF PF12661.7 EAK90179.1 - 1.7 9.4 14.0 0.12 13.1 7.5 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF TSP_1 PF00090.19 EAK90180.1 - 1.6e-25 89.1 41.5 5.2e-10 39.4 9.7 4.1 3 1 1 4 4 4 3 Thrombospondin type 1 domain EGF PF00008.27 EAK90180.1 - 3.7e-08 33.5 7.0 2.6e-07 30.8 7.0 2.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EAK90180.1 - 0.00085 19.9 4.4 0.00085 19.9 4.4 2.9 3 0 0 3 3 3 1 Human growth factor-like EGF CRT-like PF08627.10 EAK90180.1 - 0.053 12.5 0.4 0.088 11.7 0.4 1.2 1 0 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like tRNA-synt_1e PF01406.19 EAK90181.1 - 2.8e-125 417.6 0.0 4.2e-125 417.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EAK90181.1 - 9.2e-07 27.9 2.3 0.017 13.9 0.1 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EAK90181.1 - 0.00058 18.2 0.0 0.004 15.5 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Cmc1 PF08583.10 EAK90181.1 - 0.011 15.7 1.0 0.082 12.9 0.3 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Cas_Csn2 PF09711.10 EAK90181.1 - 0.013 15.2 0.5 0.013 15.2 0.5 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csn2) tRNA-synt_1f PF01921.18 EAK90181.1 - 0.017 14.1 0.1 2.1 7.2 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) DALR_2 PF09190.11 EAK90181.1 - 0.017 15.6 0.0 0.11 13.0 0.0 2.5 1 1 1 2 2 2 0 DALR domain tRNA-synt_1c PF00749.21 EAK90181.1 - 0.039 12.8 0.0 0.12 11.2 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain MSA-2c PF12238.8 EAK90181.1 - 0.053 13.5 1.7 0.17 11.9 1.7 1.9 1 1 0 1 1 1 0 Merozoite surface antigen 2c Nod1 PF17114.5 EAK90181.1 - 0.33 11.1 1.8 2.1 8.5 0.0 2.6 3 0 0 3 3 3 0 Gef2-related medial cortical node protein Nod1 Methyltrans_RNA PF04452.14 EAK90182.1 - 3.1e-44 151.0 0.1 5.4e-38 130.6 0.0 2.1 1 1 1 2 2 2 2 RNA methyltransferase Ebp2 PF05890.12 EAK90183.1 - 9.4e-38 130.3 26.5 1.1e-37 130.0 26.5 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Ribosomal_L26 PF16906.5 EAK90184.1 - 3.2e-35 120.4 2.9 4.1e-35 120.1 2.9 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EAK90184.1 - 5.4e-05 23.0 3.2 0.0001 22.1 3.2 1.5 1 0 0 1 1 1 1 KOW motif Methyltrans_RNA PF04452.14 EAK90184.1 - 0.0014 18.0 0.2 0.0016 17.8 0.2 1.2 1 0 0 1 1 1 1 RNA methyltransferase Tubulin PF00091.25 EAK90185.1 - 3.3e-69 233.0 0.0 6.7e-69 232.0 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EAK90185.1 - 2.1e-40 137.8 0.1 3.2e-40 137.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EAK90185.1 - 0.00011 22.4 0.0 0.00028 21.2 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EAK90185.1 - 0.031 14.0 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 EAK90185.1 - 0.045 12.9 0.0 0.08 12.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Taeniidae_ag PF05596.11 EAK90187.1 - 0.044 13.8 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Taeniidae antigen ORC_WH_C PF18137.1 EAK90187.1 - 0.11 12.6 1.5 0.25 11.4 1.5 1.6 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Pkinase PF00069.25 EAK90188.1 - 7e-43 146.9 0.0 2.8e-42 144.9 0.0 2.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90188.1 - 7.5e-22 77.8 0.0 1.3e-18 67.2 0.0 3.7 2 1 0 2 2 2 2 Protein tyrosine kinase Dicty_CAD PF05720.12 EAK90189.1 - 0.055 13.5 0.2 0.14 12.2 0.2 1.6 1 0 0 1 1 1 0 Cell-cell adhesion domain CRAL_TRIO PF00650.20 EAK90190.1 - 6.1e-08 32.5 0.1 1.8e-07 31.0 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO domain UME PF08064.13 EAK90190.1 - 0.067 13.1 0.1 0.43 10.5 0.1 2.4 2 0 0 2 2 2 0 UME (NUC010) domain HTH_Tnp_Tc3_1 PF11427.8 EAK90190.1 - 0.088 12.7 0.1 1.2 9.1 0.0 2.6 2 0 0 2 2 2 0 Tc3 transposase TssO PF17561.2 EAK90192.1 - 0.0075 16.4 1.6 0.013 15.6 0.5 1.8 1 1 1 2 2 2 1 Type VI secretion system, TssO CDT1_C PF16679.5 EAK90192.1 - 0.059 13.8 0.4 0.12 12.9 0.4 1.6 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Cathelicidins PF00666.17 EAK90192.1 - 0.16 12.3 2.4 0.47 10.8 2.4 1.8 1 1 0 1 1 1 0 Cathelicidin Asp-B-Hydro_N PF05279.11 EAK90192.1 - 3.1 7.8 14.6 5 7.1 14.6 1.4 1 1 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SbmA_BacA PF05992.12 EAK90193.1 - 7.3e-40 137.3 6.7 8.8e-40 137.1 6.7 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family MIF4G PF02854.19 EAK90193.1 - 0.039 13.6 1.9 1.9 8.1 0.4 2.2 2 0 0 2 2 2 0 MIF4G domain EpoR_lig-bind PF09067.10 EAK90193.1 - 0.1 12.8 0.4 0.42 10.9 0.0 2.0 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding DUF2207 PF09972.9 EAK90193.1 - 0.42 9.3 2.1 0.59 8.8 2.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SbmA_BacA PF05992.12 EAK90194.1 - 1.1e-49 169.5 14.6 1.4e-49 169.2 14.6 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 EAK90194.1 - 3e-05 23.6 8.9 3e-05 23.6 8.9 2.3 2 1 0 2 2 2 1 ABC transporter transmembrane region 2 DUF3523 PF12037.8 EAK90195.1 - 5.2e-76 255.5 22.5 7.4e-76 255.0 22.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 EAK90195.1 - 1.4e-23 83.8 0.0 2.9e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EAK90195.1 - 0.00095 19.6 0.1 0.19 12.1 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EAK90195.1 - 0.0011 18.7 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EAK90195.1 - 0.0022 18.1 2.1 0.004 17.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EAK90195.1 - 0.0034 17.1 0.2 0.0098 15.6 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EAK90195.1 - 0.0076 15.8 0.2 0.03 13.9 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EAK90195.1 - 0.0084 15.5 0.0 0.028 13.8 0.0 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zot PF05707.12 EAK90195.1 - 0.0085 15.7 0.0 0.067 12.8 0.0 2.4 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_22 PF13401.6 EAK90195.1 - 0.011 16.0 2.7 0.12 12.6 0.0 3.0 3 1 0 3 3 2 0 AAA domain NACHT PF05729.12 EAK90195.1 - 0.015 15.3 0.1 0.04 13.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 EAK90195.1 - 0.02 14.9 0.0 0.063 13.3 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EAK90195.1 - 0.049 13.6 0.1 0.049 13.6 0.1 2.9 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 EAK90195.1 - 0.069 13.3 0.1 0.26 11.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_lid_3 PF17862.1 EAK90195.1 - 0.082 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA+ lid domain AAA_18 PF13238.6 EAK90195.1 - 0.082 13.4 0.1 0.082 13.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain Transthyretin PF00576.21 EAK90195.1 - 0.15 12.8 1.4 0.37 11.5 1.4 1.6 1 0 0 1 1 1 0 HIUase/Transthyretin family AAA_11 PF13086.6 EAK90195.1 - 1.1 9.0 0.0 1.1 9.0 0.0 3.2 2 1 0 2 2 1 0 AAA domain BRAP2 PF07576.12 EAK90196.1 - 0.11 12.7 0.0 0.47 10.7 0.0 2.0 2 0 0 2 2 2 0 BRCA1-associated protein 2 Cgr1 PF03879.14 EAK90198.1 - 0.0026 18.1 26.6 0.0033 17.8 26.6 1.1 1 0 0 1 1 1 1 Cgr1 family Casc1 PF12366.8 EAK90198.1 - 0.49 9.9 6.7 0.58 9.6 6.7 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 CRF PF00473.17 EAK90198.1 - 1.3 9.2 4.0 3.5 7.8 4.0 1.9 1 1 0 1 1 1 0 Corticotropin-releasing factor family PhoD PF09423.10 EAK90199.1 - 3.9e-16 59.0 0.0 7.9e-14 51.4 0.0 2.1 2 0 0 2 2 2 2 PhoD-like phosphatase OAD_gamma PF04277.13 EAK90199.1 - 0.24 12.0 0.9 0.54 10.9 0.9 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TPR_1 PF00515.28 EAK90200.1 - 1.1e-15 56.7 2.3 0.011 15.5 0.1 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EAK90200.1 - 3.9e-11 42.2 17.7 0.17 12.1 0.2 7.8 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EAK90200.1 - 1.1e-10 40.8 11.9 0.2 12.0 0.0 7.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 EAK90200.1 - 1.8e-08 34.8 2.2 0.09 13.3 0.0 5.6 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EAK90200.1 - 1.2e-07 31.6 11.3 0.0024 18.1 0.1 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EAK90200.1 - 2.1e-07 31.1 14.4 0.036 14.4 0.8 6.8 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EAK90200.1 - 8.1e-06 26.2 5.4 20 6.4 0.0 7.1 4 1 3 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 EAK90200.1 - 9.2e-06 26.2 3.1 0.025 15.2 0.0 4.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 EAK90200.1 - 1.2e-05 25.4 0.1 0.13 12.5 0.0 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK90200.1 - 5e-05 23.5 16.2 0.17 12.2 0.3 5.4 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EAK90200.1 - 0.00011 21.9 8.1 0.24 11.5 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EAK90200.1 - 0.0002 21.0 0.1 0.0002 21.0 0.1 5.6 8 1 1 9 9 8 2 TPR repeat ANAPC8 PF04049.13 EAK90200.1 - 0.0009 19.3 0.1 0.0048 16.9 0.0 2.2 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_6 PF13174.6 EAK90200.1 - 0.009 16.6 9.8 13 6.7 0.0 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EAK90200.1 - 0.1 12.5 0.9 89 3.2 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EAK90200.1 - 0.11 12.6 4.0 22 5.2 0.0 5.3 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EAK90200.1 - 8.4 6.5 6.6 2.9 8.0 0.0 3.6 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain HTH_36 PF13730.6 EAK90201.1 - 0.036 14.0 0.7 1.4 8.9 0.1 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain TFIIB PF00382.19 EAK90201.1 - 0.095 12.8 0.0 5.5 7.1 0.0 3.0 4 0 0 4 4 4 0 Transcription factor TFIIB repeat CBS PF00571.28 EAK90202.1 - 0.05 14.1 0.0 0.26 11.7 0.0 2.2 3 0 0 3 3 3 0 CBS domain tRNA-synt_1b PF00579.25 EAK90203.1 - 2.7e-21 76.2 0.0 4.6e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF5074 PF16819.5 EAK90203.1 - 0.048 13.7 0.1 1.8 8.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5074) His_Phos_2 PF00328.22 EAK90204.1 - 3.5e-50 171.5 3.1 1.9e-49 169.0 3.1 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EAK90204.1 - 1.3e-35 121.4 0.2 8.1e-35 118.9 0.2 2.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EAK90204.1 - 0.0014 18.3 0.0 0.0038 16.9 0.0 1.7 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Frankia_peptide PF14407.6 EAK90204.1 - 0.16 12.0 0.0 23 5.0 0.0 2.5 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. NOB1_Zn_bind PF08772.11 EAK90206.1 - 1.1e-21 76.7 1.8 2.8e-21 75.4 1.8 1.7 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EAK90206.1 - 1.1e-20 73.9 0.0 2.1e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease Presenilin PF01080.17 EAK90206.1 - 0.27 10.0 3.4 0.39 9.4 3.4 1.1 1 0 0 1 1 1 0 Presenilin Pes-10 PF07149.11 EAK90206.1 - 2 7.4 15.6 2.8 6.9 15.6 1.2 1 0 0 1 1 1 0 Pes-10 Lactamase_B_4 PF13691.6 EAK90208.1 - 7.7e-10 38.3 0.0 3.9e-09 36.1 0.0 2.3 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EAK90208.1 - 1.9e-08 34.1 0.0 0.0027 17.3 0.0 2.6 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EAK90208.1 - 6.1e-06 25.8 0.2 0.042 13.3 0.1 2.6 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EAK90208.1 - 0.0001 22.4 0.0 0.00027 21.0 0.0 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily hSac2 PF12456.8 EAK90208.1 - 0.011 15.5 0.1 0.028 14.1 0.1 1.7 1 0 0 1 1 1 0 Inositol phosphatase DUF3978 PF13123.6 EAK90209.1 - 0.022 14.5 1.5 0.028 14.1 1.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3978) TaqI_C PF12950.7 EAK90209.1 - 0.038 14.1 0.8 0.043 13.9 0.8 1.2 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain Nic96 PF04097.14 EAK90210.1 - 5.6e-10 38.3 7.0 5.6e-05 21.8 0.1 2.3 2 0 0 2 2 2 2 Nup93/Nic96 DUF1617 PF07761.12 EAK90210.1 - 0.023 14.8 0.1 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1617) DMAP1_like PF17024.5 EAK90210.1 - 0.73 10.0 4.8 0.56 10.3 0.6 3.0 3 0 0 3 3 3 0 Putative DMAP1-like Mga PF05043.13 EAK90210.1 - 2 9.1 7.3 1.9 9.1 0.0 4.4 4 0 0 4 4 4 0 Mga helix-turn-helix domain Ribosomal_L10 PF00466.20 EAK90211.1 - 7.6e-17 61.3 0.5 1.3e-16 60.5 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EAK90211.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 Insertion domain in 60S ribosomal protein L10P ER_lumen_recept PF00810.18 EAK90212.1 - 1.6e-15 58.2 4.9 1.6e-15 58.2 4.9 2.1 2 2 0 2 2 2 1 ER lumen protein retaining receptor Rad51 PF08423.11 EAK90213.1 - 9e-119 395.4 0.0 1.4e-118 394.8 0.0 1.3 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EAK90213.1 - 8e-11 41.9 0.3 1.2e-10 41.4 0.3 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EAK90213.1 - 6.7e-07 29.1 0.0 1.3e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EAK90213.1 - 1.5e-06 28.7 1.0 3.4e-06 27.6 1.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA PF00004.29 EAK90213.1 - 0.00057 20.3 0.5 0.0043 17.5 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EAK90213.1 - 0.0021 17.4 2.0 0.0023 17.3 0.3 2.0 2 1 0 2 2 2 1 KaiC RNA_pol_A_CTD PF03118.15 EAK90213.1 - 0.02 14.6 0.5 0.041 13.6 0.5 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain HHH PF00633.23 EAK90213.1 - 0.026 14.4 0.1 0.05 13.5 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_3 PF12836.7 EAK90213.1 - 0.069 13.4 0.2 0.47 10.8 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif CPL PF08144.11 EAK90213.1 - 0.073 13.4 0.0 9.2 6.6 0.1 2.5 2 1 0 2 2 2 0 CPL (NUC119) domain HHH_6 PF14579.6 EAK90213.1 - 0.14 12.5 0.4 2.9 8.2 0.1 2.6 1 1 1 2 2 2 0 Helix-hairpin-helix motif Histone PF00125.24 EAK90214.1 - 4.3e-16 59.5 0.3 6.1e-16 59.0 0.3 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EAK90214.1 - 0.00038 20.7 0.0 0.00077 19.7 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EAK90214.1 - 0.0013 19.2 0.0 0.002 18.6 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A tRNA-synt_2b PF00587.25 EAK90215.1 - 1.1e-32 113.4 0.1 5.7e-30 104.6 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EAK90215.1 - 3.6e-19 68.7 0.1 1.1e-18 67.1 0.1 1.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 EAK90215.1 - 2.2e-11 43.7 0.3 7.5e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EAK90215.1 - 1.1e-08 35.0 0.0 1.2e-07 31.6 0.0 2.6 2 1 0 2 2 2 1 TGS domain LCCL PF03815.19 EAK90216.1 - 1.4e-22 79.6 0.4 1.4e-22 79.6 0.4 3.1 3 0 0 3 3 3 1 LCCL domain F5_F8_type_C PF00754.25 EAK90216.1 - 2.1e-10 40.8 6.8 0.00018 21.7 0.1 3.3 3 0 0 3 3 3 2 F5/8 type C domain DUF1080 PF06439.11 EAK90216.1 - 5.5e-05 23.4 3.4 0.094 12.8 0.0 2.4 2 0 0 2 2 2 2 Domain of Unknown Function (DUF1080) PHD PF00628.29 EAK90217.1 - 0.00037 20.3 6.5 0.0011 18.8 6.5 1.9 1 0 0 1 1 1 1 PHD-finger ubiquitin PF00240.23 EAK90218.1 - 0.00039 20.1 0.0 0.0005 19.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family FucT_N PF18025.1 EAK90218.1 - 0.07 13.6 0.0 0.095 13.2 0.0 1.2 1 0 0 1 1 1 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain ARID PF01388.21 EAK90219.1 - 1.8e-14 54.1 0.2 1.9e-13 50.9 0.0 2.8 2 1 1 3 3 3 1 ARID/BRIGHT DNA binding domain Xpo1 PF08389.12 EAK90220.1 - 2.2e-30 105.7 2.8 2.2e-30 105.7 2.8 4.2 6 0 0 6 6 6 1 Exportin 1-like protein Phage_int_SAM_5 PF13102.6 EAK90220.1 - 0.49 10.8 3.4 0.96 9.8 0.2 3.1 3 0 0 3 3 3 0 Phage integrase SAM-like domain Lum_binding PF00677.17 EAK90221.1 - 0.22 11.5 0.5 3.2 7.8 0.1 3.1 4 0 0 4 4 4 0 Lumazine binding domain Glyco_trans_1_4 PF13692.6 EAK90222.1 - 7.1e-09 36.2 0.0 2.4e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EAK90222.1 - 2.1e-05 24.1 0.0 7.7e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 TRAPP PF04051.16 EAK90223.1 - 3.6e-32 111.1 0.0 4.4e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component UDPGP PF01704.18 EAK90224.1 - 3.5e-21 75.3 0.0 6.5e-21 74.5 0.0 1.5 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Pkinase PF00069.25 EAK90225.1 - 9.1e-70 235.0 0.0 1.4e-69 234.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90225.1 - 3.1e-28 98.8 0.0 5e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EAK90225.1 - 3.2e-21 73.2 6.6 9.3e-07 28.0 0.4 4.8 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAK90225.1 - 4.2e-20 72.0 2.2 2.7e-11 43.8 1.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAK90225.1 - 1.1e-15 56.1 6.2 0.00064 19.5 0.0 4.8 5 0 0 5 5 4 3 EF-hand domain EF-hand_8 PF13833.6 EAK90225.1 - 1.4e-15 56.8 4.6 0.0004 20.2 0.3 4.5 3 1 1 4 4 4 4 EF-hand domain pair CBM_20 PF00686.19 EAK90225.1 - 3.8e-12 45.9 0.0 8.4e-12 44.8 0.0 1.6 1 1 0 1 1 1 1 Starch binding domain EF-hand_5 PF13202.6 EAK90225.1 - 5.7e-12 44.6 8.1 0.00013 21.3 0.3 4.0 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EAK90225.1 - 5.9e-07 29.7 0.2 0.00066 20.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EAK90225.1 - 9.2e-05 22.7 0.4 3.8 7.9 0.1 3.4 1 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EAK90225.1 - 0.00015 21.6 0.6 0.0088 16.0 0.2 2.5 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Kdo PF06293.14 EAK90225.1 - 0.0005 19.5 0.0 0.00098 18.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EAK90225.1 - 0.088 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Dockerin_1 PF00404.18 EAK90225.1 - 0.12 12.6 1.6 1.3 9.3 0.4 2.9 2 1 1 3 3 2 0 Dockerin type I domain EMP24_GP25L PF01105.24 EAK90226.1 - 3.4e-32 111.8 4.4 4.2e-32 111.6 4.4 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 EAK90226.1 - 0.008 16.4 0.1 0.012 15.8 0.1 1.2 1 0 0 1 1 1 1 SdrD B-like domain DUF4160 PF13711.6 EAK90226.1 - 0.027 14.8 0.3 0.1 12.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) DUF2524 PF10732.9 EAK90226.1 - 0.28 11.5 3.2 0.37 11.1 2.1 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2524) DUF1947 PF09183.10 EAK90226.1 - 0.41 11.0 3.6 3.6 8.0 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) KH_1 PF00013.29 EAK90228.1 - 2.9e-18 65.5 16.1 1.4e-11 44.1 1.3 6.4 7 0 0 7 7 7 3 KH domain SLS PF14611.6 EAK90228.1 - 1.6e-07 31.4 17.0 0.00033 20.5 0.2 4.7 1 1 4 5 5 5 3 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EAK90228.1 - 0.0005 19.8 2.7 0.0029 17.4 0.1 3.3 3 0 0 3 3 3 1 KH domain KH_4 PF13083.6 EAK90228.1 - 0.34 10.8 2.3 0.42 10.5 0.0 2.5 3 0 0 3 3 3 0 KH domain DUF2067 PF09840.9 EAK90228.1 - 1.4 8.4 10.9 0.4 10.2 0.3 4.8 5 1 1 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2067) Pyr_redox_2 PF07992.14 EAK90229.1 - 8.6e-35 120.4 0.0 1.1e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EAK90229.1 - 5.8e-07 30.0 0.1 5.4e-06 26.9 0.3 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SopE_GEF PF07487.13 EAK90229.1 - 0.01 16.0 0.3 8.7 6.5 0.1 2.9 3 0 0 3 3 3 0 SopE GEF domain DUF2200 PF09966.9 EAK90229.1 - 0.1 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) SPT16 PF08644.11 EAK90230.1 - 3e-42 144.4 0.5 3e-42 144.4 0.5 3.4 2 1 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EAK90230.1 - 5.9e-29 100.9 0.1 5.9e-29 100.9 0.1 2.4 3 0 0 3 3 3 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EAK90230.1 - 8.1e-24 84.5 0.0 1.3e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EAK90230.1 - 4.7e-17 62.2 0.0 1.4e-16 60.7 0.0 1.9 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Codanin-1_C PF15296.6 EAK90230.1 - 5.7 7.0 8.5 0.25 11.4 1.3 2.2 2 0 0 2 2 2 0 Codanin-1 C-terminus FapA PF03961.13 EAK90231.1 - 0.0011 17.7 14.4 0.0011 17.7 14.4 2.0 1 1 1 2 2 2 1 Flagellar Assembly Protein A Cob_adeno_trans PF01923.18 EAK90231.1 - 0.0025 18.0 10.8 0.021 15.0 0.3 3.8 1 1 2 4 4 4 2 Cobalamin adenosyltransferase Uso1_p115_C PF04871.13 EAK90231.1 - 0.041 14.3 19.0 0.81 10.1 0.4 3.4 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1411 PF07199.11 EAK90231.1 - 0.97 9.1 4.2 1.1 8.9 1.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1411) Tropomyosin_1 PF12718.7 EAK90231.1 - 2 8.5 23.1 0.034 14.3 12.9 2.8 2 1 0 2 2 2 0 Tropomyosin like GTP-bdg_M PF16360.5 EAK90231.1 - 2.8 8.6 6.6 5.1 7.8 3.8 2.7 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region Fungal_trans_2 PF11951.8 EAK90231.1 - 3.4 6.4 6.4 0.7 8.6 0.1 2.3 1 1 1 2 2 2 0 Fungal specific transcription factor domain Syntaxin-6_N PF09177.11 EAK90231.1 - 6.4 7.4 19.3 1.2 9.7 2.7 4.1 3 2 1 4 4 4 0 Syntaxin 6, N-terminal Polyketide_cyc PF03364.20 EAK90232.1 - 2.4e-06 27.8 0.0 3.3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Hid1 PF12722.7 EAK90233.1 - 0.014 13.5 13.0 0.023 12.8 13.0 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PA26 PF04636.13 EAK90233.1 - 0.8 8.6 13.7 1.2 8.0 13.7 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Mitofilin PF09731.9 EAK90233.1 - 0.87 8.4 27.2 1.2 7.9 27.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein ALMT PF11744.8 EAK90233.1 - 1.7 7.4 13.4 3.1 6.5 13.4 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 EAK90233.1 - 2.5 8.1 10.8 5.2 7.0 10.8 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF262 PF03235.14 EAK90233.1 - 3.5 7.7 13.9 5.5 7.1 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 Borrelia_P83 PF05262.11 EAK90233.1 - 3.7 5.9 33.9 5.2 5.4 33.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2457 PF10446.9 EAK90233.1 - 5.6 6.0 37.5 0.025 13.7 28.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Pkinase PF00069.25 EAK90235.1 - 1.5e-09 37.7 0.1 5.9e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90235.1 - 0.074 12.3 0.0 0.53 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine kinase HEAT PF02985.22 EAK90236.1 - 5.3e-07 29.4 0.1 0.15 12.4 0.0 3.8 3 0 0 3 3 3 3 HEAT repeat Phage_holin_3_3 PF16083.5 EAK90236.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III Vac14_Fab1_bd PF12755.7 EAK90236.1 - 0.12 12.9 0.0 22 5.8 0.0 3.0 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF848 PF05852.11 EAK90236.1 - 0.27 11.4 6.6 1.1 9.4 6.6 2.0 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF948 PF06103.11 EAK90236.1 - 1 9.7 5.7 0.49 10.7 1.0 2.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 EAK90236.1 - 9 6.8 10.0 25 5.4 2.7 3.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Metallophos_2 PF12850.7 EAK90238.1 - 2.9e-17 63.4 0.0 3.4e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EAK90238.1 - 0.0015 19.0 0.2 0.041 14.4 0.2 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase P4Ha_N PF08336.11 EAK90239.1 - 0.052 13.6 3.8 0.36 10.9 0.1 2.9 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Peptidase_M16_C PF05193.21 EAK90240.1 - 6.3e-25 88.2 0.0 4.9e-24 85.4 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EAK90240.1 - 2.1e-12 47.2 0.1 3.8e-12 46.4 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) WD40 PF00400.32 EAK90241.1 - 0.00046 20.9 0.9 1.6 9.7 0.0 4.5 3 0 0 3 3 3 1 WD domain, G-beta repeat SPC25 PF06703.11 EAK90241.1 - 5.8 6.7 6.8 6.7 6.5 0.2 3.5 4 0 0 4 4 4 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Ribosomal_L2_C PF03947.18 EAK90242.1 - 8.7e-44 148.8 3.2 1.3e-43 148.2 3.2 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EAK90242.1 - 1.3e-14 53.9 0.3 4.7e-14 52.1 0.1 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain DDE_Tnp_1_6 PF13751.6 EAK90244.1 - 0.033 14.4 0.1 0.082 13.1 0.1 1.6 1 0 0 1 1 1 0 Transposase DDE domain ECSIT_C PF14784.6 EAK90244.1 - 0.089 13.1 0.0 0.089 13.1 0.0 2.4 3 1 0 3 3 3 0 C-terminal domain of the ECSIT protein PAT1 PF09770.9 EAK90245.1 - 6.5 4.9 18.6 1.8 6.7 0.2 2.6 2 1 1 3 3 3 0 Topoisomerase II-associated protein PAT1 Guanylate_kin PF00625.21 EAK90247.1 - 8.9e-48 162.4 0.2 9.9e-48 162.2 0.2 1.0 1 0 0 1 1 1 1 Guanylate kinase Rad17 PF03215.15 EAK90247.1 - 3.9e-05 23.7 0.0 5.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 EAK90247.1 - 0.0002 21.3 0.1 0.00051 20.0 0.0 1.7 1 1 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 EAK90247.1 - 0.0016 18.8 0.2 0.0054 17.1 0.1 2.0 1 1 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 EAK90247.1 - 0.0016 18.6 0.2 0.017 15.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EAK90247.1 - 0.0023 18.2 0.0 0.0052 17.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EAK90247.1 - 0.0055 17.2 0.1 0.0085 16.6 0.1 1.7 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EAK90247.1 - 0.0069 16.8 0.0 0.0078 16.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF3970 PF13113.6 EAK90247.1 - 0.0077 16.4 0.1 0.67 10.2 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3970) AAA_18 PF13238.6 EAK90247.1 - 0.01 16.4 0.1 0.053 14.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EAK90247.1 - 0.012 16.1 0.0 0.02 15.3 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EAK90247.1 - 0.022 14.7 0.8 0.067 13.1 0.8 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Roc PF08477.13 EAK90247.1 - 0.025 14.8 0.1 0.061 13.5 0.0 1.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EAK90247.1 - 0.025 14.7 0.0 0.049 13.7 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.6 EAK90247.1 - 0.029 14.8 1.7 0.51 10.8 0.0 2.8 2 1 1 3 3 3 0 AAA domain NTPase_1 PF03266.15 EAK90247.1 - 0.045 13.7 0.1 0.12 12.3 0.1 2.0 1 1 0 1 1 1 0 NTPase AAA_7 PF12775.7 EAK90247.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EAK90247.1 - 0.12 12.4 0.6 0.43 10.6 0.1 2.2 1 1 0 2 2 2 0 AAA domain cobW PF02492.19 EAK90247.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EAK90247.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 EAK90247.1 - 0.18 11.7 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 EAK90247.1 - 0.19 11.5 0.1 0.32 10.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1682 PF07946.14 EAK90251.1 - 1.8e-65 221.3 3.5 2.1e-65 221.1 3.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Ribosomal_S3_C PF00189.20 EAK90252.1 - 5.7e-26 90.8 2.2 1.4e-25 89.6 1.3 2.1 3 0 0 3 3 3 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EAK90252.1 - 1.5e-09 37.6 0.1 2.4e-09 36.9 0.1 1.4 1 0 0 1 1 1 1 KH domain DUF4848 PF16140.5 EAK90254.1 - 0.051 13.1 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4848) AAA PF00004.29 EAK90256.1 - 1.9e-10 41.3 0.1 5.6e-10 39.8 0.1 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EAK90256.1 - 2.5e-07 31.0 0.0 1.2e-06 28.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EAK90256.1 - 3e-07 31.0 0.0 1.3e-06 28.9 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EAK90256.1 - 8.7e-07 29.1 1.5 1.6e-06 28.2 1.5 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EAK90256.1 - 0.0012 19.1 0.0 0.0032 17.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EAK90256.1 - 0.0021 17.6 0.3 0.069 12.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region T2SSE PF00437.20 EAK90256.1 - 0.0046 16.0 0.0 0.0088 15.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein UvrD-helicase PF00580.21 EAK90256.1 - 0.0082 15.7 1.5 0.1 12.1 0.0 2.2 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_14 PF13173.6 EAK90256.1 - 0.011 15.8 1.1 0.38 10.8 0.1 3.0 2 1 0 3 3 3 0 AAA domain PIF1 PF05970.14 EAK90256.1 - 0.013 14.7 0.0 0.042 13.0 0.0 1.8 1 0 0 1 1 1 0 PIF1-like helicase NTPase_1 PF03266.15 EAK90256.1 - 0.014 15.3 0.1 0.041 13.8 0.1 1.9 1 1 0 1 1 1 0 NTPase AAA_11 PF13086.6 EAK90256.1 - 0.042 13.6 0.0 0.042 13.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_lid_10 PF17872.1 EAK90256.1 - 0.049 13.8 0.2 0.24 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA lid domain ABC_tran PF00005.27 EAK90256.1 - 0.055 14.0 0.1 0.19 12.2 0.0 1.9 2 0 0 2 2 2 0 ABC transporter MobB PF03205.14 EAK90256.1 - 0.056 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 EAK90256.1 - 0.095 13.1 0.0 0.4 11.1 0.0 2.1 1 0 0 1 1 1 0 RNA helicase AAA_26 PF13500.6 EAK90256.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EAK90256.1 - 0.12 11.8 0.0 0.89 8.9 0.0 2.4 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EAK90256.1 - 0.2 11.4 0.0 0.47 10.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pigment_DH PF06324.11 EAK90256.1 - 0.94 9.7 2.9 7.7 6.8 0.2 2.8 2 0 0 2 2 2 0 Pigment-dispersing hormone (PDH) Abhydrolase_6 PF12697.7 EAK90257.1 - 8e-06 26.6 0.0 1.1e-05 26.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EAK90257.1 - 1.3e-05 25.5 0.4 0.0028 17.8 0.1 3.5 2 1 0 2 2 2 1 Thioesterase domain Abhydrolase_1 PF00561.20 EAK90257.1 - 0.0048 16.6 1.3 0.16 11.6 0.3 2.5 2 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EAK90257.1 - 0.0064 15.8 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 CDC50 PF03381.15 EAK90259.1 - 3.6e-18 66.1 5.9 2.4e-12 47.0 2.6 2.2 2 0 0 2 2 2 2 LEM3 (ligand-effect modulator 3) family / CDC50 family EB1 PF03271.17 EAK90260.1 - 4.9e-10 39.5 2.6 1.1e-09 38.3 2.6 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EAK90260.1 - 2.9e-08 33.8 0.2 2.9e-08 33.8 0.2 1.9 2 1 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 EAK90260.1 - 0.037 14.1 0.8 0.037 14.1 0.8 2.1 2 0 0 2 2 2 0 CH-like domain in sperm protein Tyr-DNA_phospho PF06087.12 EAK90261.1 - 2.8e-66 224.2 1.7 3.6e-66 223.8 1.7 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EAK90261.1 - 0.0016 18.3 0.2 1.7 8.6 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain Ribosomal_L22e PF01776.17 EAK90263.1 - 1.5e-45 154.0 0.3 1.7e-45 153.8 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family MerB PF03243.15 EAK90263.1 - 0.031 14.4 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 Alkylmercury lyase eIF-5_eIF-2B PF01873.17 EAK90264.1 - 4.2e-36 123.4 0.1 8.6e-36 122.4 0.1 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EAK90264.1 - 1.9e-15 56.7 0.3 1.4e-14 54.0 0.0 2.3 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon PBP1_TM PF14812.6 EAK90264.1 - 3.5 8.1 13.6 3.6 8.0 2.6 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 EAK90264.1 - 8.2 5.5 8.0 0.15 11.2 0.7 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Tho2 PF11262.8 EAK90265.1 - 6e-17 61.8 14.9 1.2e-15 57.5 14.9 2.9 1 1 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EAK90265.1 - 2.8e-08 33.7 0.3 1.3e-07 31.6 0.3 2.2 1 0 0 1 1 1 1 Transcription- and export-related complex subunit MFS_1 PF07690.16 EAK90266.1 - 1.5e-05 24.1 25.5 1.5e-05 24.1 25.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TcpE PF12648.7 EAK90267.1 - 0.01 16.3 0.2 0.01 16.3 0.2 2.5 3 0 0 3 3 3 0 TcpE family 14-3-3 PF00244.20 EAK90268.1 - 3.5e-14 52.9 3.7 4e-14 52.7 3.7 1.0 1 0 0 1 1 1 1 14-3-3 protein NAS PF03059.16 EAK90268.1 - 0.011 15.1 0.5 0.015 14.7 0.5 1.2 1 0 0 1 1 1 0 Nicotianamine synthase protein MIS13 PF08202.11 EAK90268.1 - 0.018 14.3 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Rotavirus_VP7 PF05868.11 EAK90268.1 - 0.082 12.3 3.0 0.15 11.4 2.8 1.5 1 1 0 1 1 1 0 Rotavirus major outer capsid protein VP7 Cyclin PF08613.11 EAK90270.1 - 1.6e-17 64.4 0.0 1.6e-17 64.4 0.0 2.2 2 1 0 3 3 3 1 Cyclin DUF389 PF04087.14 EAK90271.1 - 5e-05 23.4 8.2 0.0024 17.9 0.1 3.4 1 1 1 2 2 2 1 Domain of unknown function (DUF389) DUF2157 PF09925.9 EAK90271.1 - 0.013 15.3 0.8 0.013 15.3 0.8 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) TauE PF01925.19 EAK90271.1 - 0.021 14.4 18.4 0.06 13.0 18.2 1.9 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE Ceramidase PF05875.12 EAK90271.1 - 0.039 13.4 2.8 0.022 14.2 1.0 1.5 1 1 0 1 1 1 0 Ceramidase Caa3_CtaG PF09678.10 EAK90271.1 - 0.066 12.7 1.5 0.094 12.2 1.5 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) LapA_dom PF06305.11 EAK90271.1 - 0.14 12.0 0.1 0.14 12.0 0.1 4.1 3 1 0 4 4 4 0 Lipopolysaccharide assembly protein A domain SDF PF00375.18 EAK90271.1 - 0.17 10.9 16.7 0.23 10.4 9.1 2.5 3 0 0 3 3 3 0 Sodium:dicarboxylate symporter family DUF4131 PF13567.6 EAK90271.1 - 0.27 10.9 7.0 3 7.5 2.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) UPF0182 PF03699.13 EAK90271.1 - 2.2 6.3 5.8 0.52 8.4 1.8 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0182) FTR1 PF03239.14 EAK90271.1 - 3.2 6.8 11.8 0.12 11.5 0.9 2.9 2 1 0 2 2 2 0 Iron permease FTR1 family RAMP4 PF06624.12 EAK90271.1 - 7.3 6.7 8.7 21 5.3 1.8 2.8 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 TMEM220 PF15071.6 EAK90272.1 - 0.043 14.6 1.3 0.096 13.4 1.2 1.7 1 1 0 1 1 1 0 Transmembrane family 220, helix DUF2663 PF10864.8 EAK90272.1 - 2.6 8.5 8.9 0.13 12.6 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) Big_2 PF02368.18 EAK90273.1 - 0.029 14.3 0.0 6.6 6.7 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 2) DUF365 PF04033.12 EAK90273.1 - 0.16 12.3 2.1 0.37 11.1 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF365) Ribosomal_L35Ae PF01247.18 EAK90274.1 - 9.2e-40 134.7 0.4 1.1e-39 134.4 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae DUF2935 PF11155.8 EAK90275.1 - 0.82 10.0 4.0 1 9.7 0.9 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) CTV_P6 PF06706.11 EAK90275.1 - 3 7.6 4.6 5.3 6.8 0.9 2.9 3 0 0 3 3 3 0 Citrus tristeza virus 6-kDa protein FtsJ PF01728.19 EAK90276.1 - 6.6e-24 85.0 0.2 1.1e-20 74.5 0.0 3.1 3 0 0 3 3 3 2 FtsJ-like methyltransferase TPT PF03151.16 EAK90277.1 - 7.4e-09 35.4 18.6 3.2e-08 33.3 15.5 2.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.20 EAK90277.1 - 1.1e-06 28.9 0.9 1.1e-06 28.9 0.9 3.4 3 0 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 EAK90277.1 - 0.0034 17.0 12.6 0.0034 17.0 12.6 2.5 2 1 0 2 2 2 1 Solute carrier family 35 DUF4083 PF13314.6 EAK90277.1 - 0.09 12.7 0.3 0.09 12.7 0.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) Kelch_1 PF01344.25 EAK90279.1 - 7e-31 105.6 2.2 7.2e-08 31.9 0.0 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EAK90279.1 - 5.4e-29 100.0 5.1 1.8e-07 31.0 0.0 6.6 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EAK90279.1 - 3.4e-21 74.8 11.1 1.3e-06 28.4 0.0 6.8 4 2 2 6 6 6 4 Kelch motif BTB_2 PF02214.22 EAK90279.1 - 3e-15 56.3 0.1 1.1e-14 54.6 0.1 2.0 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 EAK90279.1 - 6.6e-12 44.9 6.3 0.075 13.0 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EAK90279.1 - 4.9e-11 42.6 1.3 0.46 10.8 0.0 6.2 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EAK90279.1 - 0.00084 19.3 7.2 2.1 8.4 0.0 4.8 7 0 0 7 7 7 2 Kelch motif zf-C4H2 PF10146.9 EAK90279.1 - 0.29 11.4 10.5 0.44 10.8 10.5 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein PulA_N1 PF17999.1 EAK90279.1 - 3.3 8.5 6.8 7.3 7.4 2.3 2.5 2 0 0 2 2 2 0 Pullulanase N1-terminal domain AAA_lid_9 PF17871.1 EAK90280.1 - 1.5e-06 28.1 0.0 6e-06 26.1 0.0 2.0 1 0 0 1 1 1 1 AAA lid domain TIP49 PF06068.13 EAK90280.1 - 4.2e-05 22.9 0.0 0.00014 21.1 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 EAK90280.1 - 0.0038 17.2 0.0 0.014 15.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK90280.1 - 0.0075 16.7 0.0 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EAK90280.1 - 0.032 14.0 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EAK90280.1 - 0.043 13.3 0.0 1.6 8.2 0.0 2.8 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 EAK90280.1 - 0.045 12.8 0.6 12 4.8 0.0 3.2 3 0 0 3 3 3 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EAK90280.1 - 0.076 12.7 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein APS_kinase PF01583.20 EAK90280.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Patatin PF01734.22 EAK90281.1 - 2.6e-06 27.8 0.2 0.00027 21.2 0.2 2.5 1 1 0 1 1 1 1 Patatin-like phospholipase RPAP1_N PF08621.10 EAK90281.1 - 2.8 7.8 4.4 0.84 9.5 0.4 2.2 3 0 0 3 3 3 0 RPAP1-like, N-terminal TPR_19 PF14559.6 EAK90282.1 - 3.9e-11 43.3 0.0 1.1e-05 25.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EAK90282.1 - 4.1e-09 35.9 0.3 0.11 12.7 0.0 4.9 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EAK90282.1 - 3.5e-08 33.3 0.0 0.00016 21.9 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EAK90282.1 - 9.8e-07 29.3 0.0 0.0059 17.2 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EAK90282.1 - 5.9e-06 26.7 0.0 0.088 13.7 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EAK90282.1 - 1.6e-05 24.8 4.7 0.85 10.0 0.0 5.8 7 0 0 7 7 6 1 Tetratricopeptide repeat PknG_TPR PF16918.5 EAK90282.1 - 0.00024 20.0 0.1 0.00041 19.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_1 PF00515.28 EAK90282.1 - 0.0015 18.3 0.1 1.2 9.1 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK90282.1 - 0.0044 17.2 0.1 1.5 9.1 0.1 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EAK90282.1 - 0.0098 15.9 0.0 9.6 6.5 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EAK90282.1 - 0.01 15.5 0.5 3.8 7.3 0.2 3.2 1 1 1 2 2 2 0 TPR repeat TPR_12 PF13424.6 EAK90282.1 - 0.14 12.4 0.0 5.2 7.4 0.0 3.2 3 1 0 4 4 4 0 Tetratricopeptide repeat S-AdoMet_synt_C PF02773.16 EAK90283.1 - 5.5e-62 207.8 0.2 2e-61 206.0 0.0 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EAK90283.1 - 1.6e-43 147.8 0.0 2.8e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EAK90283.1 - 3.4e-41 140.0 1.1 5.9e-41 139.2 0.3 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EAK90283.1 - 0.023 13.5 0.3 0.4 9.4 0.0 2.1 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Rad17 PF03215.15 EAK90284.1 - 7.7e-12 45.5 5.7 8.7e-12 45.3 0.1 2.7 2 1 0 3 3 3 1 Rad17 P-loop domain AAA_23 PF13476.6 EAK90284.1 - 3.5e-06 27.6 1.6 3.5e-06 27.6 1.6 4.1 3 1 0 3 3 3 1 AAA domain ABC_tran PF00005.27 EAK90284.1 - 0.00014 22.4 0.0 0.0004 20.9 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA PF00004.29 EAK90284.1 - 0.0012 19.3 0.0 0.0028 18.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EAK90284.1 - 0.0025 18.1 0.0 0.0069 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EAK90284.1 - 0.0089 16.0 0.1 0.034 14.0 0.1 2.0 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EAK90284.1 - 0.022 15.1 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 EAK90284.1 - 0.027 14.0 0.0 0.057 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EAK90284.1 - 0.033 14.2 0.0 0.15 12.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EAK90284.1 - 0.04 13.7 0.1 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EAK90284.1 - 0.053 13.9 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 EAK90284.1 - 0.062 12.7 0.5 0.13 11.7 0.5 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF916 PF06030.12 EAK90284.1 - 0.064 13.3 2.2 0.16 12.0 0.2 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) cobW PF02492.19 EAK90284.1 - 0.087 12.4 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EAK90284.1 - 0.23 11.2 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Adap_comp_sub PF00928.21 EAK90285.1 - 5.2e-85 285.0 3.2 6.4e-85 284.7 3.2 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EAK90285.1 - 7.7e-08 32.4 3.2 1.4e-07 31.5 3.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain OMPdecase PF00215.24 EAK90286.1 - 0.062 12.9 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF1507 PF07408.11 EAK90286.1 - 0.36 10.7 2.2 14 5.7 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1507) DCP2 PF05026.13 EAK90287.1 - 2.4e-19 69.4 2.6 5.8e-19 68.2 2.6 1.7 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EAK90287.1 - 9.7e-11 41.8 0.0 1.8e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain ABC_membrane_2 PF06472.15 EAK90288.1 - 3.6e-42 144.6 9.2 6.3e-42 143.8 9.2 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EAK90288.1 - 8.9e-18 65.1 0.0 2e-17 64.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SbmA_BacA PF05992.12 EAK90288.1 - 2e-08 34.0 2.8 6e-08 32.5 2.8 1.8 1 1 0 1 1 1 1 SbmA/BacA-like family AAA_23 PF13476.6 EAK90288.1 - 0.00099 19.7 2.4 0.026 15.0 0.2 2.9 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EAK90288.1 - 0.0011 18.5 0.0 0.0027 17.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_29 PF13555.6 EAK90288.1 - 0.0021 17.7 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 EAK90288.1 - 0.0034 17.3 0.0 0.0096 15.8 0.0 1.8 2 0 0 2 2 2 1 NACHT domain Sigma54_activat PF00158.26 EAK90288.1 - 0.004 16.9 0.0 0.35 10.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain SMC_N PF02463.19 EAK90288.1 - 0.0046 16.4 0.2 0.013 14.9 0.2 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 EAK90288.1 - 0.0077 15.9 15.1 0.033 13.9 15.1 2.0 1 1 0 1 1 1 1 ABC transporter transmembrane region RsgA_GTPase PF03193.16 EAK90288.1 - 0.0081 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EAK90288.1 - 0.019 15.3 0.0 0.034 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EAK90288.1 - 0.026 14.6 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase GPW_gp25 PF04965.14 EAK90288.1 - 0.04 13.7 0.1 0.5 10.2 0.0 2.6 3 0 0 3 3 3 0 Gene 25-like lysozyme MCM PF00493.23 EAK90288.1 - 0.079 12.0 0.0 0.19 10.8 0.0 1.6 1 0 0 1 1 1 0 MCM P-loop domain AAA_5 PF07728.14 EAK90288.1 - 0.08 12.9 0.1 8.3 6.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EAK90288.1 - 0.085 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Roc PF08477.13 EAK90288.1 - 0.086 13.1 0.3 0.21 11.8 0.3 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RTT107_BRCT_6 PF16771.5 EAK90289.1 - 0.35 11.1 5.4 6.5 7.0 0.2 3.7 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain Baculo_LEF-2 PF03041.14 EAK90290.1 - 0.11 12.2 4.0 9 5.9 0.6 3.6 3 0 0 3 3 3 0 lef-2 DUF469 PF04320.14 EAK90290.1 - 0.11 13.3 0.2 0.55 11.1 0.1 2.3 2 0 0 2 2 2 0 Protein with unknown function (DUF469) BRCT_2 PF16589.5 EAK90290.1 - 0.13 12.7 3.0 1.5 9.3 0.1 3.9 3 0 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EAK90290.1 - 0.51 10.8 8.2 6.2 7.3 0.1 4.3 4 1 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain Peptidase_C50 PF03568.17 EAK90291.1 - 2.4e-41 142.2 4.0 2.4e-41 142.2 4.0 4.1 3 1 0 3 3 3 1 Peptidase family C50 DUF3833 PF12915.7 EAK90291.1 - 0.024 14.2 0.0 0.057 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) NOT2_3_5 PF04153.18 EAK90292.1 - 8e-31 106.8 10.1 1.4e-30 106.0 10.1 1.4 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family KID PF02524.14 EAK90293.1 - 1.4 9.3 4.4 1.3 9.4 0.1 3.6 3 0 0 3 3 3 0 KID repeat Kin17_mid PF10357.9 EAK90294.1 - 4.3e-39 133.3 7.4 4.3e-39 133.3 7.4 1.5 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EAK90294.1 - 0.0024 18.2 3.8 0.0082 16.5 3.8 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EAK90294.1 - 0.0046 17.2 3.2 0.015 15.5 3.2 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF4097 PF13349.6 EAK90294.1 - 0.0097 15.3 1.3 0.018 14.4 1.3 1.4 1 0 0 1 1 1 1 Putative adhesin Nup54_57_C PF18570.1 EAK90294.1 - 0.039 13.5 0.1 0.083 12.5 0.1 1.6 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain OAS1_C PF10421.9 EAK90296.1 - 0.015 14.8 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Peptidase_C1 PF00112.23 EAK90297.1 - 3.4e-38 131.9 2.6 6.8e-38 130.9 2.6 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EAK90297.1 - 0.00033 19.5 2.2 0.00036 19.4 0.1 1.9 2 0 0 2 2 2 1 Peptidase C1-like family zf-HC5HC2H PF13771.6 EAK90299.1 - 0.014 15.6 7.5 0.045 14.0 7.5 1.9 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EAK90299.1 - 0.17 12.0 5.9 0.41 10.8 5.9 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain TFIID_20kDa PF03847.13 EAK90300.1 - 2.6e-05 24.6 0.0 6.9e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 EAK90300.1 - 0.00042 20.7 0.0 0.0007 20.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF643 PF04867.12 EAK90300.1 - 0.004 17.8 0.1 0.012 16.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF643) TFIID-31kDa PF02291.15 EAK90300.1 - 0.02 15.0 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIID-18kDa PF02269.16 EAK90300.1 - 0.047 13.7 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit JAB PF01398.21 EAK90301.1 - 2.5e-29 101.7 0.0 3.8e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EAK90301.1 - 3.5e-27 95.1 0.1 5.6e-27 94.4 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Pox_MCEL PF03291.16 EAK90302.1 - 4.9e-41 140.9 8.5 4.2e-40 137.9 8.5 2.2 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EAK90302.1 - 6.9e-13 49.1 0.0 1.6e-12 47.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK90302.1 - 6e-11 42.4 0.1 1.3e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK90302.1 - 5.3e-10 39.9 0.0 1.4e-09 38.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK90302.1 - 2.3e-09 37.3 0.0 4.6e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAK90302.1 - 7e-09 36.2 0.0 1.3e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain mRNA_triPase PF02940.15 EAK90302.1 - 8.9e-05 22.3 1.9 0.00012 21.9 0.1 2.0 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain CMAS PF02353.20 EAK90302.1 - 0.0068 15.7 0.3 0.015 14.6 0.0 1.7 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 EAK90302.1 - 0.019 15.0 0.2 0.046 13.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_5 PF01795.19 EAK90302.1 - 0.022 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 MraW methylase family Methyltransf_20 PF12147.8 EAK90302.1 - 0.065 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Topoisom_I_N PF02919.15 EAK90302.1 - 0.1 12.1 0.9 0.75 9.3 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment MCM PF00493.23 EAK90304.1 - 2.1e-98 327.9 0.2 4e-98 327.0 0.2 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EAK90304.1 - 9.6e-31 106.3 0.1 1.7e-30 105.4 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EAK90304.1 - 3.9e-27 94.5 1.5 8.8e-27 93.4 1.5 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EAK90304.1 - 8e-08 32.8 0.3 0.00037 21.0 0.2 2.7 2 0 0 2 2 2 2 MCM N-terminal domain Mg_chelatase PF01078.21 EAK90304.1 - 2.1e-06 27.3 0.0 3.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EAK90304.1 - 0.0065 16.5 0.0 0.03 14.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EAK90304.1 - 0.068 12.9 0.0 0.19 11.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 EAK90304.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Clat_adaptor_s PF01217.20 EAK90305.1 - 0.0038 17.2 2.2 0.0068 16.3 2.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Hexapep PF00132.24 EAK90307.1 - 4.3e-06 26.2 19.7 0.0013 18.4 3.2 3.9 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EAK90307.1 - 0.001 18.7 11.5 1.4 8.7 0.2 3.4 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EAK90307.1 - 0.0049 15.8 7.2 0.015 14.2 2.4 2.0 1 1 1 2 2 2 2 L-fucokinase Phytochelatin_C PF09328.10 EAK90308.1 - 0.048 13.0 1.8 0.087 12.1 1.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1984) Rhomboid PF01694.22 EAK90309.1 - 3.4e-25 88.8 16.5 3.4e-25 88.8 16.5 1.7 2 0 0 2 2 2 1 Rhomboid family CCDC14 PF15254.6 EAK90310.1 - 8.6 4.9 8.1 11 4.5 8.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Maf1 PF09174.10 EAK90311.1 - 9.9e-36 123.5 3.4 1.5e-35 122.9 3.4 1.3 1 1 0 1 1 1 1 Maf1 regulator IPK PF03770.16 EAK90312.1 - 7.5e-14 52.0 1.4 3.5e-13 49.9 0.7 2.3 2 0 0 2 2 2 1 Inositol polyphosphate kinase DUF1062 PF06353.12 EAK90312.1 - 0.0047 17.8 0.1 0.0095 16.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1062) HEAT_EZ PF13513.6 EAK90313.1 - 1.4e-12 47.9 4.5 1.6e-06 28.4 0.0 7.9 7 1 1 8 8 8 1 HEAT-like repeat HEAT PF02985.22 EAK90313.1 - 1.2e-08 34.5 15.9 0.0016 18.5 0.0 8.9 11 1 0 11 11 11 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EAK90313.1 - 1.1e-06 29.1 0.1 0.059 14.0 0.0 3.4 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 EAK90313.1 - 3.5e-06 26.8 0.4 3.5e-06 26.8 0.4 2.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cnd1 PF12717.7 EAK90313.1 - 0.0003 20.8 0.7 0.025 14.6 0.0 4.0 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EAK90313.1 - 0.03 13.9 0.1 14 5.2 0.0 3.7 4 0 0 4 4 4 0 CLASP N terminal mRNA_stabil PF13929.6 EAK90313.1 - 0.069 12.1 0.1 0.14 11.2 0.1 1.4 1 0 0 1 1 1 0 mRNA stabilisation Arm PF00514.23 EAK90313.1 - 0.68 10.1 7.4 15 5.8 0.3 5.0 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Peptidase_M60_C PF18630.1 EAK90314.1 - 3.3 7.9 4.6 0.91 9.7 0.3 2.3 2 0 0 2 2 2 0 Peptidase M60 C-terminal domain GCP_C_terminal PF04130.13 EAK90315.1 - 1.2e-26 94.0 8.7 3.4e-26 92.5 8.7 1.9 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Pkinase PF00069.25 EAK90316.1 - 1.2e-42 146.1 0.3 1.2e-42 146.1 0.3 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90316.1 - 1.4e-11 44.2 0.1 2.4e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Sec15 PF04091.12 EAK90317.1 - 0.0082 15.6 1.6 0.014 14.8 0.2 1.9 1 1 0 1 1 1 1 Exocyst complex subunit Sec15-like DUF2746 PF10874.8 EAK90317.1 - 0.047 14.1 0.1 0.13 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) LXG PF04740.12 EAK90317.1 - 0.12 12.1 0.2 1.7 8.3 0.0 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily RWD PF05773.22 EAK90318.1 - 0.25 11.6 6.0 15 5.9 0.8 3.7 2 1 0 3 3 3 0 RWD domain LsmAD PF06741.13 EAK90319.1 - 4e-12 46.5 2.2 4e-12 46.5 2.2 2.6 2 1 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 EAK90319.1 - 3.9e-05 23.7 0.0 9.3e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 EAK90319.1 - 0.0015 18.1 2.1 0.0015 18.1 2.1 1.7 2 0 0 2 2 2 1 Ataxin-2 C-terminal region COPIIcoated_ERV PF07970.12 EAK90320.1 - 1.9e-57 194.7 0.6 2.7e-57 194.2 0.6 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EAK90320.1 - 9.6e-24 83.6 4.8 4.9e-23 81.3 1.1 2.4 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF4139 PF13598.6 EAK90320.1 - 0.19 11.4 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) FOP_dimer PF09398.10 EAK90321.1 - 0.029 14.6 0.8 0.072 13.4 0.2 2.0 2 0 0 2 2 2 0 FOP N terminal dimerisation domain Get5_C PF18514.1 EAK90321.1 - 0.093 12.5 0.7 8.3 6.2 0.1 2.6 2 0 0 2 2 2 0 Get5 C-terminal domain LisH_TPL PF17814.1 EAK90321.1 - 1.4 8.6 5.9 0.21 11.3 0.5 2.4 3 0 0 3 3 3 0 LisH-like dimerisation domain LMBR1 PF04791.16 EAK90322.1 - 9.6e-67 226.0 33.0 1.2e-66 225.7 33.0 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Scs3p PF10261.9 EAK90323.1 - 0.0003 20.4 2.3 0.00052 19.6 1.5 1.7 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM ASFV_J13L PF05568.11 EAK90323.1 - 0.32 10.7 0.4 0.98 9.1 0.4 1.8 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF1514 PF07438.11 EAK90323.1 - 0.44 10.4 4.3 0.14 12.0 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) zf-CCCH PF00642.24 EAK90324.1 - 7.6e-06 25.7 8.5 8.4e-05 22.4 0.8 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EAK90324.1 - 9.2e-05 22.6 0.7 0.00021 21.5 0.1 1.9 2 0 0 2 2 2 1 Zinc-finger containing family Torus PF16131.5 EAK90324.1 - 0.0029 18.3 3.4 0.013 16.1 0.7 2.5 1 1 1 2 2 2 1 Torus domain zf-CCCH_4 PF18044.1 EAK90324.1 - 0.026 14.3 1.7 0.026 14.3 1.7 2.9 3 0 0 3 3 3 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EAK90324.1 - 0.028 14.5 3.0 0.028 14.5 3.0 3.1 3 0 0 3 3 3 0 Zinc finger domain SLBP_RNA_bind PF15247.6 EAK90326.1 - 1.1e-20 73.5 0.8 1.1e-20 73.5 0.8 2.5 3 1 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain SUR7 PF06687.12 EAK90327.1 - 0.029 14.0 0.5 0.046 13.3 0.5 1.3 1 0 0 1 1 1 0 SUR7/PalI family DUF768 PF05589.11 EAK90327.1 - 0.081 12.9 1.2 0.29 11.2 1.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF768) DUF724 PF05266.14 EAK90327.1 - 2.4 7.9 7.4 0.53 10.1 3.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Importin_rep_4 PF18808.1 EAK90328.1 - 1.4e-15 57.4 0.5 1.4e-15 57.4 0.5 4.4 3 2 2 5 5 5 1 Importin repeat HEAT PF02985.22 EAK90328.1 - 2.1e-11 43.0 1.0 0.0012 18.9 0.0 7.4 6 0 0 6 6 5 2 HEAT repeat RIX1 PF08167.12 EAK90328.1 - 2.5e-08 33.9 4.2 0.011 15.4 0.3 5.8 5 2 0 5 5 5 2 rRNA processing/ribosome biogenesis HEAT_EZ PF13513.6 EAK90328.1 - 1.9e-07 31.5 0.1 0.064 13.8 0.0 6.2 5 2 2 7 7 6 2 HEAT-like repeat IFRD PF05004.13 EAK90328.1 - 7.9e-07 28.5 0.2 0.00051 19.3 0.0 4.4 4 1 1 5 5 5 1 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 EAK90328.1 - 1.4e-06 28.6 0.0 0.0022 18.3 0.0 5.2 4 1 2 6 6 6 2 HEAT repeats Tti2 PF10521.9 EAK90328.1 - 9.2e-06 25.4 1.0 4.8 6.6 0.0 5.5 3 2 1 4 4 4 2 Tti2 family Vac14_Fab1_bd PF12755.7 EAK90328.1 - 2e-05 25.1 1.5 0.34 11.5 0.0 5.9 6 1 1 7 7 7 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 EAK90328.1 - 0.0097 15.9 0.0 3.1 8.0 0.0 4.4 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat UME PF08064.13 EAK90328.1 - 0.014 15.3 11.3 2.8 7.9 0.0 6.6 6 2 1 8 8 8 0 UME (NUC010) domain Ipi1_N PF12333.8 EAK90328.1 - 0.015 15.9 2.3 21 5.8 0.0 5.4 7 0 0 7 7 7 0 Rix1 complex component involved in 60S ribosome maturation DUF3385 PF11865.8 EAK90328.1 - 0.068 13.1 18.7 5 7.0 0.0 7.2 5 3 2 8 8 8 0 Domain of unknown function (DUF3385) MMS19_N PF14500.6 EAK90328.1 - 0.073 12.6 2.1 3.2 7.2 0.0 3.4 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II IBN_N PF03810.19 EAK90328.1 - 1.3 9.0 7.0 0.99 9.4 0.5 3.7 3 0 0 3 3 3 0 Importin-beta N-terminal domain SWIB PF02201.18 EAK90329.1 - 1.2e-06 28.3 0.6 1.2e-06 28.3 0.6 2.5 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 EAK90329.1 - 0.0091 15.9 0.4 0.033 14.1 0.0 2.2 2 0 0 2 2 2 1 DEK C terminal domain DIT1_PvcA PF05141.12 EAK90329.1 - 0.041 13.3 2.7 0.082 12.4 1.3 2.2 1 1 0 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein RRT14 PF17075.5 EAK90329.1 - 4.6 7.3 19.0 1.3 9.1 2.7 2.9 3 0 0 3 3 3 0 Regular of rDNA transcription protein 14 TMC PF07810.13 EAK90330.1 - 4.4 7.9 6.7 1.1 9.8 3.2 2.0 2 1 0 2 2 2 0 TMC domain UPF0172 PF03665.13 EAK90331.1 - 2.1e-21 76.8 0.0 4.8e-21 75.7 0.0 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 EAK90331.1 - 0.00023 21.1 0.0 0.00035 20.5 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CLPTM1 PF05602.12 EAK90332.1 - 2.9e-98 329.7 15.8 3.8e-98 329.3 15.8 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EAK90332.1 - 0.00078 19.2 3.0 0.0083 15.9 0.2 3.3 2 0 0 2 2 2 1 PQ loop repeat UbiA PF01040.18 EAK90332.1 - 0.38 10.0 8.4 0.042 13.2 3.2 2.0 2 0 0 2 2 2 0 UbiA prenyltransferase family FHA PF00498.26 EAK90333.1 - 9.7e-20 70.7 0.5 3.3e-13 49.8 0.4 2.8 2 0 0 2 2 2 2 FHA domain zf-C3HC4_4 PF15227.6 EAK90333.1 - 3e-09 36.9 9.3 1.5e-08 34.7 9.7 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EAK90333.1 - 6.9e-09 35.6 8.1 1.4e-08 34.6 5.6 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EAK90333.1 - 8.3e-09 35.2 6.1 1.6e-08 34.3 6.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK90333.1 - 1.2e-08 34.7 10.1 2.6e-08 33.6 10.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK90333.1 - 2.5e-08 33.7 9.1 7.3e-08 32.2 9.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK90333.1 - 2.2e-06 27.9 9.5 6.3e-06 26.4 9.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EAK90333.1 - 0.00022 21.1 9.4 0.00065 19.6 9.5 1.8 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EAK90333.1 - 0.00048 19.9 8.5 0.0016 18.3 8.2 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EAK90333.1 - 0.001 19.2 3.5 0.0022 18.1 3.5 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EAK90333.1 - 0.032 14.1 3.4 0.081 12.8 3.4 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EAK90333.1 - 0.097 12.5 8.7 0.054 13.3 3.5 2.9 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EAK90333.1 - 1.5 9.1 8.0 9.2 6.6 8.2 2.2 1 1 1 2 2 2 0 RING-H2 zinc finger domain ELMO_CED12 PF04727.13 EAK90334.1 - 2.3e-45 154.8 0.5 3.9e-45 154.1 0.5 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family TcA_TcB_BD PF18276.1 EAK90336.1 - 0.0027 16.9 0.2 0.0036 16.4 0.2 1.2 1 0 0 1 1 1 1 Tc toxin complex TcA C-terminal TcB-binding domain Ribosomal_S17e PF00833.18 EAK90336.1 - 0.092 12.7 0.4 9 6.2 0.0 2.4 2 0 0 2 2 2 0 Ribosomal S17 Vma12 PF11712.8 EAK90337.1 - 0.72 9.9 3.2 0.47 10.5 0.4 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Patatin PF01734.22 EAK90338.1 - 1e-14 55.2 0.0 2.2e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Fzo_mitofusin PF04799.13 EAK90338.1 - 0.024 14.2 0.8 0.054 13.0 0.8 1.6 1 0 0 1 1 1 0 fzo-like conserved region DASH_Duo1 PF08651.10 EAK90338.1 - 0.61 9.9 5.7 0.62 9.9 3.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Duo1 ER_lumen_recept PF00810.18 EAK90339.1 - 1.2e-27 97.6 12.8 3.2e-27 96.2 12.8 1.8 1 1 0 1 1 1 1 ER lumen protein retaining receptor SNF5 PF04855.12 EAK90341.1 - 0.00026 20.9 0.1 0.00043 20.2 0.1 1.4 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 HNF-1_N PF04814.13 EAK90341.1 - 0.0024 18.5 0.1 0.0024 18.5 0.1 2.7 4 0 0 4 4 4 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Pkinase PF00069.25 EAK90343.1 - 2.3e-49 168.1 0.0 4.2e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90343.1 - 1.6e-47 162.0 0.0 2.2e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAK90343.1 - 0.018 14.4 0.0 0.046 13.0 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EAK90343.1 - 0.019 14.3 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.16 EAK90345.1 - 2e-22 79.6 38.1 4.3e-20 71.9 4.8 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 EAK90345.1 - 8.1e-16 57.9 25.0 4.8e-15 55.4 2.3 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 EAK90345.1 - 2.6e-08 32.6 24.8 0.00012 20.5 4.7 3.9 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family Sigma_reg_N PF13800.6 EAK90345.1 - 2.1 8.7 9.4 3.6 8.0 1.6 3.6 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Tir_receptor_C PF07489.11 EAK90345.1 - 2.9 7.8 6.7 0.21 11.5 1.4 1.7 1 1 1 2 2 2 0 Translocated intimin receptor (Tir) C-terminus HypA PF01155.19 EAK90346.1 - 0.0038 17.2 1.2 0.014 15.4 0.2 2.5 3 0 0 3 3 3 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Bromodomain PF00439.25 EAK90347.1 - 0.0054 16.8 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain tRNA_int_end_N2 PF12928.7 EAK90347.1 - 0.062 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term Leo1 PF04004.13 EAK90348.1 - 1.4e-08 34.8 0.0 2e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Leo1-like protein Ribosomal_L1 PF00687.21 EAK90349.1 - 1.9e-45 155.1 5.1 2.3e-45 154.9 5.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PP2C PF00481.21 EAK90350.1 - 3.2e-54 184.3 0.2 2.3e-53 181.5 0.2 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EAK90350.1 - 0.053 13.2 0.0 0.12 12.0 0.0 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C DUF4456 PF14644.6 EAK90353.1 - 0.056 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) CTU2 PF10288.9 EAK90353.1 - 0.1 12.9 0.1 0.27 11.5 0.1 1.7 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Tn7_Tnp_TnsA_N PF08722.11 EAK90353.1 - 0.12 12.6 0.2 0.36 11.1 0.2 1.8 1 0 0 1 1 1 0 TnsA endonuclease N terminal zinc_ribbon_16 PF17034.5 EAK90353.1 - 0.41 10.9 2.0 1.6 8.9 0.1 2.3 2 0 0 2 2 2 0 Zinc-ribbon like family Mpp10 PF04006.12 EAK90354.1 - 2.3e-40 138.7 46.6 9.2e-40 136.7 41.5 3.4 1 1 1 2 2 2 1 Mpp10 protein CTD_bind PF04818.13 EAK90355.1 - 0.0078 17.0 1.9 0.017 15.9 0.4 2.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CDC73_N PF16050.5 EAK90355.1 - 0.085 12.2 1.0 0.11 11.8 0.2 1.5 2 0 0 2 2 2 0 Paf1 complex subunit CDC73 N-terminal PRMT5 PF05185.16 EAK90356.1 - 1.6e-61 207.2 0.4 2.6e-61 206.5 0.4 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EAK90356.1 - 9e-44 149.4 3.6 9e-44 149.4 3.6 1.7 2 0 0 2 2 2 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 EAK90356.1 - 5.7e-30 104.4 1.2 9.4e-30 103.7 1.2 1.3 1 0 0 1 1 1 1 PRMT5 TIM barrel domain TehB PF03848.14 EAK90356.1 - 5.6e-05 22.6 0.2 0.00015 21.2 0.2 1.7 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_25 PF13649.6 EAK90356.1 - 0.0011 19.7 0.0 0.0022 18.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK90356.1 - 0.0089 16.8 0.0 0.022 15.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EAK90356.1 - 0.056 13.0 0.1 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain PP2C PF00481.21 EAK90357.1 - 5.6e-41 140.9 0.0 1.1e-40 139.9 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EAK90357.1 - 0.00044 20.2 0.0 0.00084 19.3 0.0 1.5 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) OCRE PF17780.1 EAK90357.1 - 0.04 13.9 0.2 0.089 12.8 0.2 1.6 1 0 0 1 1 1 0 OCRE domain Defb50 PF17546.2 EAK90357.1 - 0.099 12.6 0.2 0.43 10.5 0.2 2.2 1 0 0 1 1 1 0 Beta defensin 50 NTP_transf_2 PF01909.23 EAK90358.1 - 1e-06 29.0 0.0 2.8e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EAK90358.1 - 1e-05 25.6 0.2 2.3e-05 24.5 0.2 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase Carb_kinase PF01256.17 EAK90359.1 - 2.3e-47 161.5 0.0 4.9e-35 121.2 0.0 2.1 2 0 0 2 2 2 2 Carbohydrate kinase E2F_TDP PF02319.20 EAK90360.1 - 1.7e-11 44.0 0.6 4e-11 42.8 0.6 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.10 EAK90360.1 - 0.0003 20.7 0.6 0.00068 19.6 0.6 1.5 1 0 0 1 1 1 1 Transcription factor DP IFT20 PF14931.6 EAK90360.1 - 0.039 14.1 0.4 0.072 13.3 0.4 1.5 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 HSP90 PF00183.18 EAK90361.1 - 2.7e-154 514.9 18.6 1e-147 493.2 14.9 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c PF02518.26 EAK90361.1 - 5.1e-11 43.1 0.1 1e-10 42.1 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EAK90361.1 - 5.9e-11 42.4 0.1 2.4e-10 40.4 0.1 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_2 PF07719.17 EAK90362.1 - 3.5e-25 86.0 8.9 0.0017 18.3 0.0 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 EAK90362.1 - 1.3e-23 81.7 10.5 1.8e-07 30.6 0.1 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 EAK90362.1 - 2.6e-19 68.6 2.0 2.1e-06 27.3 0.0 5.3 4 2 2 6 6 5 3 TPR repeat TPR_19 PF14559.6 EAK90362.1 - 2.2e-13 50.5 0.1 0.0044 17.5 0.0 5.5 4 1 1 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EAK90362.1 - 7.8e-13 48.5 4.7 0.00027 21.2 0.6 5.0 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EAK90362.1 - 2.4e-12 46.0 5.1 1.1e-05 25.3 0.2 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EAK90362.1 - 1e-11 45.3 0.0 0.00011 22.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EAK90362.1 - 1.5e-10 41.0 0.0 0.021 15.6 0.2 6.1 4 2 3 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK90362.1 - 6.9e-10 39.0 19.7 1.2e-06 28.6 0.7 6.2 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EAK90362.1 - 2.6e-08 33.7 3.3 1.1 9.8 0.1 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EAK90362.1 - 1.2e-05 24.9 0.7 6.7 7.0 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EAK90362.1 - 0.0031 18.0 0.4 32 5.4 0.0 5.5 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EAK90362.1 - 0.0042 17.2 0.0 5.4 7.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EAK90362.1 - 0.012 15.5 1.8 8.4 6.4 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EAK90362.1 - 0.02 14.9 6.9 1.2 9.2 0.4 3.4 3 1 1 4 4 3 0 Putative TPR-like repeat TOM20_plant PF06552.12 EAK90362.1 - 0.031 14.0 0.2 0.11 12.3 0.0 2.0 2 0 0 2 2 1 0 Plant specific mitochondrial import receptor subunit TOM20 SHNi-TPR PF10516.9 EAK90362.1 - 0.06 12.8 0.0 1.3 8.6 0.0 2.6 2 0 0 2 2 2 0 SHNi-TPR TPR_4 PF07721.14 EAK90362.1 - 0.07 13.8 0.0 76 4.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Coatomer_E PF04733.14 EAK90362.1 - 0.1 12.0 0.1 0.26 10.6 0.1 1.7 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_15 PF13429.6 EAK90362.1 - 0.12 11.6 1.6 0.53 9.5 0.1 2.6 2 1 0 3 3 3 0 Tetratricopeptide repeat Serglycin PF04360.12 EAK90362.1 - 0.13 12.2 0.1 0.3 11.0 0.1 1.5 1 0 0 1 1 1 0 Serglycin TPR_3 PF07720.12 EAK90362.1 - 0.26 11.3 1.4 15 5.7 0.2 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat MIT PF04212.18 EAK90362.1 - 0.99 9.5 8.2 2.2 8.4 0.2 4.3 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Suf PF05843.14 EAK90363.1 - 0.00012 22.2 2.5 0.00012 22.2 2.5 3.7 3 2 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EAK90363.1 - 0.00022 21.8 0.0 0.5 11.3 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EAK90363.1 - 0.00083 19.8 0.0 8.7 6.9 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EAK90363.1 - 0.0027 17.7 0.0 5.9 7.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAK90363.1 - 0.0039 17.3 0.1 29 5.2 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat HAT PF02184.16 EAK90363.1 - 0.009 16.0 23.2 4.3 7.4 0.0 6.4 7 0 0 7 7 7 3 HAT (Half-A-TPR) repeat TPR_1 PF00515.28 EAK90363.1 - 0.041 13.7 0.0 20 5.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EAK90363.1 - 0.07 13.2 20.7 0.14 12.2 1.1 6.4 2 2 3 6 6 6 0 U3 small nucleolar RNA-associated protein 6 Mad3_BUB1_I PF08311.12 EAK90363.1 - 0.14 12.1 7.8 9.5 6.2 0.0 5.5 5 2 0 5 5 5 0 Mad3/BUB1 homology region 1 Baculo_IE-1 PF05290.11 EAK90364.1 - 0.01 15.8 0.6 0.014 15.4 0.6 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Allexi_40kDa PF05549.11 EAK90364.1 - 0.26 10.8 3.0 0.3 10.6 3.0 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein LRR_4 PF12799.7 EAK90365.1 - 1.2e-08 35.1 64.0 0.055 13.9 1.4 10.2 7 4 3 11 11 11 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EAK90365.1 - 0.00012 22.2 46.2 1.3 9.8 0.0 12.3 14 1 0 14 14 14 6 Leucine Rich Repeat LRR_8 PF13855.6 EAK90365.1 - 0.71 9.7 37.7 0.3 10.9 5.2 8.4 7 3 1 8 8 8 0 Leucine rich repeat LRR_6 PF13516.6 EAK90365.1 - 5.7 7.3 44.8 0.89 9.8 0.4 11.5 13 1 1 14 14 14 0 Leucine Rich repeat polyprenyl_synt PF00348.17 EAK90366.1 - 3e-44 151.0 0.0 3.9e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase RNA_pol_Rpb2_6 PF00562.28 EAK90367.1 - 9.2e-128 426.6 0.0 1.3e-127 426.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EAK90367.1 - 2.2e-56 190.6 0.0 3.1e-56 190.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EAK90367.1 - 2.5e-44 151.2 0.0 5.3e-44 150.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EAK90367.1 - 1e-31 109.2 0.9 2.1e-31 108.1 0.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EAK90367.1 - 2.7e-24 85.1 0.0 6.7e-24 83.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EAK90367.1 - 8.4e-20 71.1 1.9 2.2e-19 69.8 1.9 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 EAK90367.1 - 3.7e-19 68.8 0.1 8.7e-19 67.6 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 COG4 PF08318.12 EAK90369.1 - 2.6e-27 95.8 14.3 9.4e-27 94.0 9.2 3.4 2 1 0 2 2 2 1 COG4 transport protein DASH_Duo1 PF08651.10 EAK90369.1 - 0.33 10.7 7.3 8.8 6.2 0.0 4.2 4 0 0 4 4 4 0 DASH complex subunit Duo1 HSBP1 PF06825.12 EAK90370.1 - 4.4e-12 45.7 3.0 7.4e-12 44.9 3.0 1.4 1 0 0 1 1 1 1 Heat shock factor binding protein 1 CLZ PF16526.5 EAK90370.1 - 0.0018 18.6 2.4 0.086 13.2 0.3 2.1 1 1 1 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 EAK90370.1 - 0.026 14.6 2.6 0.033 14.2 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1043 PF06295.12 EAK90370.1 - 0.034 14.1 6.0 0.07 13.1 6.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) V-SNARE PF05008.15 EAK90370.1 - 0.064 13.6 2.3 0.14 12.5 0.9 1.9 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Fzo_mitofusin PF04799.13 EAK90370.1 - 0.11 12.1 2.9 0.13 11.8 2.9 1.2 1 0 0 1 1 1 0 fzo-like conserved region YlqD PF11068.8 EAK90370.1 - 0.23 11.9 6.0 0.1 13.0 0.9 2.0 1 1 1 2 2 2 0 YlqD protein Cyclin PF08613.11 EAK90371.1 - 1.1e-28 100.7 0.8 1.1e-28 100.7 0.8 2.0 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EAK90371.1 - 3.4e-08 33.3 0.1 6.7e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Myosin_head PF00063.21 EAK90372.1 - 8.1e-184 612.6 1.2 1e-183 612.3 1.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 EAK90372.1 - 0.0023 18.2 0.0 0.0087 16.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain DUF2780 PF11075.8 EAK90372.1 - 0.058 13.5 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) AAA_16 PF13191.6 EAK90372.1 - 0.079 13.3 0.4 0.3 11.4 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain PcfJ PF14284.6 EAK90373.1 - 0.12 12.3 0.0 0.42 10.5 0.0 1.9 1 0 0 1 1 1 0 PcfJ-like protein DUF5503 PF17607.2 EAK90377.1 - 0.16 12.3 2.7 0.63 10.4 0.1 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5503) Dev_Cell_Death PF10539.9 EAK90378.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Development and cell death domain HsbA PF12296.8 EAK90379.1 - 0.0099 16.3 0.8 0.81 10.1 0.0 4.0 5 0 0 5 5 5 1 Hydrophobic surface binding protein A Lzipper-MIP1 PF14389.6 EAK90379.1 - 0.019 15.2 0.1 0.019 15.2 0.1 4.5 4 0 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 DUF1359 PF07097.11 EAK90379.1 - 0.92 9.8 11.8 10 6.4 0.1 5.7 4 1 1 5 5 5 0 Protein of unknown function (DUF1359) CHD5 PF04420.14 EAK90379.1 - 2.3 8.1 7.7 0.26 11.1 1.7 2.6 2 0 0 2 2 2 0 CHD5-like protein Pallilysin PF18663.1 EAK90380.1 - 0.016 15.2 0.0 0.071 13.1 0.0 2.1 1 0 0 1 1 1 0 Pallilysin beta barrel domain TetR_C_27 PF17935.1 EAK90380.1 - 0.068 13.2 0.0 5.1 7.2 0.0 3.5 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain RPW8 PF05659.11 EAK90380.1 - 0.49 10.1 4.7 15 5.3 0.4 3.2 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TetR_C_19 PF17924.1 EAK90380.1 - 2.3 8.8 8.6 1.8 9.2 0.2 3.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DnaJ PF00226.31 EAK90381.1 - 1.8e-21 76.0 0.4 4.4e-21 74.8 0.4 1.7 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EAK90381.1 - 9.7e-15 54.4 0.1 1.5e-14 53.8 0.1 1.2 1 0 0 1 1 1 1 Sec63 Brl domain CrgA PF06781.12 EAK90381.1 - 0.029 14.4 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 Cell division protein CrgA TraL PF07178.11 EAK90381.1 - 0.093 13.2 0.4 0.093 13.2 0.4 2.2 3 0 0 3 3 3 0 TraL protein PspB PF06667.12 EAK90381.1 - 0.41 10.7 3.5 1 9.5 0.8 2.7 2 0 0 2 2 2 0 Phage shock protein B DUF4075 PF13294.6 EAK90382.1 - 0.0035 17.4 3.9 1.2 9.3 0.2 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4075) Tox-REase-7 PF15649.6 EAK90382.1 - 0.029 14.7 1.0 0.1 12.9 1.0 1.9 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 AATF-Che1 PF13339.6 EAK90382.1 - 0.18 12.5 3.9 2.2 9.0 1.8 2.2 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor MSC PF09402.10 EAK90383.1 - 4.4e-14 52.7 1.6 1.7e-13 50.7 0.1 2.1 1 1 1 2 2 2 1 Man1-Src1p-C-terminal domain MMtag PF10159.9 EAK90384.1 - 7.1e-17 61.5 0.8 7.1e-17 61.5 0.8 2.1 3 0 0 3 3 3 1 Multiple myeloma tumor-associated DUF1235 PF06822.12 EAK90384.1 - 0.099 11.9 0.4 0.12 11.7 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) Zn_ribbon_2 PF12674.7 EAK90385.1 - 0.1 13.3 0.8 1 10.1 0.1 2.5 2 1 0 2 2 2 0 Putative zinc ribbon domain FF PF01846.19 EAK90386.1 - 0.0015 18.7 2.5 0.1 12.8 0.0 3.9 3 1 0 3 3 3 2 FF domain PX PF00787.24 EAK90387.1 - 1e-13 51.3 0.3 2.2e-13 50.2 0.3 1.5 1 0 0 1 1 1 1 PX domain PMC2NT PF08066.12 EAK90388.1 - 0.043 14.5 0.5 0.043 14.5 0.5 4.0 4 1 0 4 4 4 0 PMC2NT (NUC016) domain DDE_Tnp_IS66 PF03050.14 EAK90388.1 - 0.085 12.3 3.4 0.043 13.3 0.6 1.8 1 1 1 2 2 2 0 Transposase IS66 family SYCP2_SLD PF18584.1 EAK90388.1 - 0.45 10.7 9.5 0.68 10.2 0.7 2.9 2 0 0 2 2 2 0 Synaptonemal complex 2 Spt16M-like domain YvrJ PF12841.7 EAK90388.1 - 2.5 7.7 5.3 1.9 8.1 0.2 3.3 3 0 0 3 3 3 0 YvrJ protein family OCRE PF17780.1 EAK90389.1 - 5.3e-18 64.8 9.5 0.051 13.6 0.0 14.0 15 1 0 15 15 15 7 OCRE domain SRP72 PF08492.12 EAK90391.1 - 2.1e-15 56.9 8.1 2.1e-15 56.9 8.1 2.1 2 0 0 2 2 2 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 EAK90391.1 - 3e-11 43.4 1.0 3e-11 43.4 1.0 3.0 2 1 0 2 2 2 1 Putative TPR-like repeat TPR_19 PF14559.6 EAK90391.1 - 2.5e-07 31.1 3.1 0.27 11.8 0.1 6.2 3 2 3 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK90391.1 - 2.8e-07 30.7 9.8 0.035 14.3 0.4 5.2 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EAK90391.1 - 9.8e-06 25.3 7.7 3.8 7.9 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EAK90391.1 - 0.0039 17.9 0.0 64 4.8 0.0 5.1 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EAK90391.1 - 0.0071 16.9 2.2 44 5.0 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EAK90391.1 - 0.014 15.2 8.9 1.9 8.5 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Csm2_III-A PF03750.13 EAK90391.1 - 0.42 11.5 3.5 2 9.3 0.1 3.2 3 0 0 3 3 3 0 Csm2 Type III-A PPR PF01535.20 EAK90391.1 - 1.8 9.0 4.0 16 6.1 0.1 4.9 6 1 1 7 7 6 0 PPR repeat TPR_8 PF13181.6 EAK90391.1 - 4.7 7.7 15.1 2.9 8.3 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat NARP1 PF12569.8 EAK90391.1 - 8.1 5.2 11.5 1.8 7.4 0.1 3.4 4 0 0 4 4 4 0 NMDA receptor-regulated protein 1 CLASP_N PF12348.8 EAK90392.1 - 1.6e-06 27.9 0.7 5.3e-06 26.2 0.7 1.8 1 1 0 1 1 1 1 CLASP N terminal RINGv PF12906.7 EAK90393.1 - 6.2e-11 42.2 1.6 6.2e-11 42.2 1.6 2.3 2 0 0 2 2 2 1 RING-variant domain FHA PF00498.26 EAK90393.1 - 9.9e-07 29.0 0.7 5.6e-06 26.6 0.1 2.7 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EAK90393.1 - 0.072 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain BING4CT PF08149.11 EAK90394.1 - 2.5e-33 113.7 0.0 5.8e-30 102.9 0.0 2.8 2 0 0 2 2 2 2 BING4CT (NUC141) domain WD40 PF00400.32 EAK90394.1 - 0.0009 20.0 3.5 12 7.0 0.1 6.0 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK90394.1 - 0.011 16.0 0.0 6 7.2 0.0 3.6 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EAK90394.1 - 0.092 12.1 0.3 1.2 8.4 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain DOR PF14839.6 EAK90394.1 - 1.8 8.5 5.1 2.9 7.8 5.1 1.3 1 0 0 1 1 1 0 DOR family Glycos_transf_2 PF00535.26 EAK90395.1 - 9.7e-07 28.8 0.0 1.8e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Csm1_B PF18211.1 EAK90395.1 - 0.055 13.3 0.6 1.9 8.4 0.0 2.6 1 1 1 2 2 2 0 Csm1 subunit domain B WD40 PF00400.32 EAK90396.1 - 4.2e-20 71.7 12.6 1.5e-05 25.7 0.4 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK90396.1 - 3.9e-14 52.7 0.5 0.00037 20.7 0.1 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EAK90396.1 - 4e-06 26.9 0.0 0.00057 19.8 0.0 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A PP2C PF00481.21 EAK90397.1 - 9.1e-23 81.2 0.0 1.6e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EAK90397.1 - 0.0033 17.1 0.0 0.032 13.9 0.0 2.5 2 1 0 2 2 2 1 Protein phosphatase 2C Glycos_transf_2 PF00535.26 EAK90398.1 - 1.8e-26 93.0 0.0 3e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EAK90398.1 - 1e-09 38.7 3.8 1.4e-08 35.1 4.2 2.1 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EAK90398.1 - 5.9e-07 29.0 0.0 1.7e-05 24.4 0.0 2.6 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 EAK90398.1 - 1.8e-06 28.0 0.0 6e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 EAK90398.1 - 0.0013 19.4 0.1 0.059 14.1 0.0 2.5 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like GlcNAc PF11397.8 EAK90398.1 - 0.24 10.8 0.4 1.4 8.3 0.4 2.0 1 1 0 1 1 1 0 Glycosyltransferase (GlcNAc) zf-RING_2 PF13639.6 EAK90399.1 - 1.3e-11 44.7 9.8 2.6e-11 43.7 9.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EAK90399.1 - 2.9e-08 33.9 6.1 7.9e-08 32.5 6.1 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EAK90399.1 - 9.7e-08 31.6 3.8 9.7e-08 31.6 3.8 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EAK90399.1 - 4.4e-05 23.2 8.3 8.3e-05 22.4 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAK90399.1 - 5.4e-05 23.0 7.8 0.00018 21.3 7.8 1.9 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAK90399.1 - 5.4e-05 23.1 6.4 0.00012 22.0 6.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EAK90399.1 - 0.00041 20.2 11.0 0.011 15.6 4.6 2.5 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EAK90399.1 - 0.00068 19.6 1.8 0.00068 19.6 1.8 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EAK90399.1 - 0.0012 18.6 8.3 0.0027 17.6 8.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EAK90399.1 - 0.0066 16.5 3.2 0.0066 16.5 3.2 2.3 3 0 0 3 3 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EAK90399.1 - 0.021 14.4 6.2 0.045 13.4 5.7 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Baculo_RING PF05883.11 EAK90399.1 - 0.043 13.8 1.3 0.089 12.8 1.3 1.5 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain Transglut_core2 PF13369.6 EAK90399.1 - 0.058 13.0 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 Transglutaminase-like superfamily zf_Rg PF17915.1 EAK90399.1 - 0.068 12.6 1.9 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 Reverse gyrase zinc finger CitMHS PF03600.16 EAK90399.1 - 0.083 12.1 1.3 0.13 11.4 1.3 1.3 1 0 0 1 1 1 0 Citrate transporter TMEM154 PF15102.6 EAK90399.1 - 0.099 12.5 0.0 0.099 12.5 0.0 2.5 3 0 0 3 3 3 0 TMEM154 protein family RINGv PF12906.7 EAK90399.1 - 0.17 12.0 8.1 0.38 10.9 8.1 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 EAK90399.1 - 0.25 11.6 8.6 0.1 12.8 5.0 2.3 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EAK90399.1 - 2 8.3 13.4 0.17 11.7 8.1 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.12 EAK90399.1 - 7.9 6.9 8.4 7.8e+02 0.5 8.5 2.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Cation_ATPase_C PF00689.21 EAK90400.1 - 9.2e-50 168.9 6.4 9.2e-50 168.9 6.4 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EAK90400.1 - 1.2e-49 168.3 1.3 1.2e-49 168.3 1.3 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EAK90400.1 - 8.5e-22 78.5 0.0 1.7e-11 44.8 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EAK90400.1 - 1.2e-16 60.5 0.0 2.8e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EAK90400.1 - 1.3e-14 53.6 0.0 3.9e-14 52.1 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EAK90400.1 - 0.00011 22.1 1.4 0.013 15.3 0.7 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EAK90400.1 - 0.0072 16.7 0.0 0.062 13.7 0.0 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EAK90400.1 - 0.13 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RNA_pol_Rpb4 PF03874.16 EAK90401.1 - 7.6e-15 55.3 1.6 8.2e-15 55.2 0.6 1.6 1 1 1 2 2 2 1 RNA polymerase Rpb4 Cpn60_TCP1 PF00118.24 EAK90402.1 - 8.8e-164 545.7 1.0 9.9e-164 545.6 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family His_Phos_1 PF00300.22 EAK90403.1 - 2.3e-37 128.6 0.0 1.1e-28 100.3 0.0 2.0 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) NIF PF03031.18 EAK90405.1 - 5.9e-25 87.9 0.1 1.1e-24 87.0 0.1 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EAK90405.1 - 4.1e-07 30.3 0.0 1.4e-06 28.5 0.0 2.0 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EAK90405.1 - 0.00016 21.5 0.1 0.00057 19.8 0.1 2.0 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 EAK90405.1 - 0.0024 18.1 0.1 0.0053 17.0 0.1 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain CAP_N PF01213.19 EAK90406.1 - 0.017 14.6 1.3 0.026 14.0 1.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EAK90406.1 - 0.11 12.5 1.2 0.22 11.6 1.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF4681 PF15732.5 EAK90406.1 - 0.23 11.7 2.5 0.63 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4681) Avl9 PF09794.9 EAK90408.1 - 0.0063 15.2 1.4 0.0076 15.0 1.4 1.1 1 0 0 1 1 1 1 Transport protein Avl9 NblA PF04485.12 EAK90408.1 - 0.009 16.4 0.9 0.12 12.8 0.1 2.6 2 1 0 2 2 2 1 Phycobilisome degradation protein nblA Lebercilin PF15619.6 EAK90408.1 - 0.065 12.9 1.5 0.081 12.6 1.5 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 EAK90408.1 - 0.079 13.4 0.6 8.2 7.0 0.1 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein KIP1 PF07765.12 EAK90408.1 - 0.15 12.2 1.1 0.76 9.9 0.3 2.2 2 1 0 2 2 2 0 KIP1-like protein MHC_II_beta PF00969.19 EAK90408.1 - 0.27 11.4 2.2 0.41 10.8 0.5 2.1 2 1 0 2 2 2 0 Class II histocompatibility antigen, beta domain Tup_N PF08581.10 EAK90408.1 - 0.27 11.5 3.1 14 6.1 0.3 2.6 1 1 1 2 2 2 0 Tup N-terminal KMP11 PF03037.16 EAK90408.1 - 0.28 12.0 2.6 1.7 9.5 0.5 2.2 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Helicase_C_2 PF13307.6 EAK90409.1 - 5.8e-43 147.0 0.4 6e-42 143.7 0.0 2.3 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EAK90409.1 - 2.8e-37 128.0 9.4 5.2e-26 91.3 2.9 4.7 3 1 0 3 3 3 2 DEAD_2 HBB PF06777.11 EAK90409.1 - 1.6e-26 93.1 0.7 2.1e-20 73.3 0.1 2.7 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 EAK90409.1 - 7.7e-12 45.5 0.0 4.3e-07 30.1 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PhoH PF02562.16 EAK90409.1 - 0.025 14.1 0.0 0.81 9.1 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein MIF4G PF02854.19 EAK90409.1 - 0.028 14.0 0.2 1.1 8.8 0.0 2.6 3 0 0 3 3 3 0 MIF4G domain SNF2_N PF00176.23 EAK90409.1 - 0.11 11.2 0.1 1 8.0 0.1 2.1 1 1 0 1 1 1 0 SNF2 family N-terminal domain MFS_1 PF07690.16 EAK90410.1 - 3.4e-21 75.6 35.9 3.4e-21 75.6 35.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1772 PF08592.11 EAK90410.1 - 0.16 12.3 9.1 4.1 7.7 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) CAP PF00188.26 EAK90411.1 - 3.4e-57 192.7 7.1 1.7e-17 64.4 0.0 4.7 4 0 0 4 4 4 4 Cysteine-rich secretory protein family Myosin_head PF00063.21 EAK90414.1 - 7.6e-182 606.1 13.6 7.6e-182 606.1 13.6 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) RCC1 PF00415.18 EAK90414.1 - 2e-34 117.9 2.0 5.2e-10 39.8 0.1 6.7 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EAK90414.1 - 2.3e-29 100.5 14.0 2.7e-10 39.7 0.7 5.6 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EAK90414.1 - 1.7e-06 27.3 38.3 0.004 16.8 0.7 7.5 7 0 0 7 7 7 4 IQ calmodulin-binding motif AAA_16 PF13191.6 EAK90414.1 - 0.015 15.7 0.0 0.048 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain CbiA PF01656.23 EAK90414.1 - 0.066 13.3 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EAK90414.1 - 0.14 12.4 0.0 0.56 10.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain MMgT PF10270.9 EAK90415.1 - 0.025 14.9 0.2 15 6.0 0.0 3.4 3 0 0 3 3 3 0 Membrane magnesium transporter DUF5598 PF18127.1 EAK90415.1 - 0.046 14.2 0.2 0.26 11.7 0.2 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5598) Streptin-Immun PF11083.8 EAK90415.1 - 2.5 8.6 7.9 16 6.0 0.1 5.1 5 0 0 5 5 5 0 Lantibiotic streptin immunity protein DUF1115 PF06544.12 EAK90416.1 - 7e-12 45.7 0.1 1.5e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.22 EAK90416.1 - 0.0086 16.4 0.2 0.029 14.7 0.1 2.0 1 1 1 2 2 2 1 RWD domain Shugoshin_N PF07558.11 EAK90416.1 - 2.3 8.1 4.9 2 8.4 0.3 2.5 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region WD40 PF00400.32 EAK90417.1 - 1.9e-19 69.6 1.4 3.6e-07 30.8 0.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF1899 PF08953.11 EAK90417.1 - 1e-15 57.3 0.1 2e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EAK90417.1 - 1.4e-15 56.9 0.2 3.1e-15 55.8 0.0 1.7 2 0 0 2 2 2 1 Type of WD40 repeat ANAPC4_WD40 PF12894.7 EAK90417.1 - 4.5e-07 30.1 0.4 0.0001 22.5 0.2 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EAK90417.1 - 0.0082 15.1 0.7 3 6.7 0.3 2.6 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PSII_BNR PF14870.6 EAK90417.1 - 0.011 15.0 0.1 0.017 14.4 0.1 1.2 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 PKcGMP_CC PF16808.5 EAK90417.1 - 0.042 13.7 0.4 0.097 12.5 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Phage_GP20 PF06810.11 EAK90417.1 - 0.05 13.4 1.8 0.083 12.7 1.8 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 Metallophos PF00149.28 EAK90418.1 - 1.3e-17 64.9 1.3 2.4e-17 64.1 1.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RIO1 PF01163.22 EAK90418.1 - 0.15 11.7 0.1 0.28 10.8 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Glycos_transf_2 PF00535.26 EAK90420.1 - 1.3e-09 38.1 0.0 2.2e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EAK90420.1 - 1.3e-05 25.2 0.0 2.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EAK90420.1 - 0.033 13.7 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 EF1G PF00647.19 EAK90421.1 - 1e-36 125.2 0.8 1.8e-36 124.5 0.3 1.6 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EAK90421.1 - 4.2e-07 30.1 0.0 8e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EAK90421.1 - 1.3e-06 28.6 0.0 2.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EAK90421.1 - 0.13 12.3 0.0 0.5 10.4 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Ribosomal_L6e PF01159.19 EAK90422.1 - 1.6e-33 115.5 1.0 2.2e-33 115.1 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Phage_attach PF05354.11 EAK90422.1 - 0.018 14.9 0.0 0.049 13.5 0.0 1.7 1 1 0 1 1 1 0 Phage Head-Tail Attachment DUF3496 PF12001.8 EAK90422.1 - 0.06 13.7 0.3 0.11 12.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) DSPn PF14671.6 EAK90423.1 - 1.3e-44 152.1 0.6 3.1e-44 150.9 0.3 1.8 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EAK90423.1 - 1.5e-10 41.0 0.2 1.2e-08 34.8 0.0 3.0 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EAK90423.1 - 0.00023 21.3 0.1 0.00069 19.8 0.0 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EAK90423.1 - 0.0015 18.2 0.0 0.0039 16.8 0.0 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RRM_1 PF00076.22 EAK90424.1 - 8.3e-32 108.8 1.6 3.8e-17 61.9 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HigB_toxin PF09907.9 EAK90424.1 - 0.021 15.1 0.2 0.092 13.0 0.1 2.0 2 0 0 2 2 2 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system RRM_7 PF16367.5 EAK90424.1 - 0.041 14.0 0.0 1.3 9.2 0.0 2.7 2 1 0 2 2 2 0 RNA recognition motif DUF5602 PF18197.1 EAK90424.1 - 0.2 12.1 0.0 0.37 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5602) DERM PF14704.6 EAK90425.1 - 0.22 12.0 1.5 13 6.2 0.0 4.2 5 0 0 5 5 5 0 Dermatopontin AbrB_C PF18277.1 EAK90426.1 - 0.11 12.1 0.3 0.26 11.0 0.3 1.6 1 0 0 1 1 1 0 AbrB C-terminal domain IL13 PF03487.13 EAK90426.1 - 0.23 11.3 1.6 0.53 10.1 1.6 1.5 1 0 0 1 1 1 0 Interleukin-13 ABC_tran PF00005.27 EAK90427.1 - 3.5e-46 157.1 0.0 5.1e-26 91.8 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EAK90427.1 - 4.7e-33 115.0 31.7 9.5e-27 94.3 11.5 3.6 3 1 1 4 4 4 3 ABC transporter transmembrane region AAA_29 PF13555.6 EAK90427.1 - 8.3e-07 28.7 0.2 0.039 13.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EAK90427.1 - 1.8e-05 24.3 13.3 0.048 13.1 1.0 4.5 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 EAK90427.1 - 0.00014 22.0 0.1 0.14 12.2 0.0 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain MMR_HSR1 PF01926.23 EAK90427.1 - 0.00015 21.8 0.2 0.0076 16.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATPase_2 PF01637.18 EAK90427.1 - 0.00075 19.5 0.0 0.18 11.7 0.0 2.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_21 PF13304.6 EAK90427.1 - 0.0012 18.7 4.1 0.06 13.1 0.2 3.6 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EAK90427.1 - 0.0013 18.7 0.1 1.3 8.9 0.0 2.7 3 0 0 3 3 3 2 RsgA GTPase NB-ARC PF00931.22 EAK90427.1 - 0.0042 16.3 0.0 1.8 7.7 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_22 PF13401.6 EAK90427.1 - 0.0086 16.4 0.0 3.9 7.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EAK90427.1 - 0.014 15.0 0.1 2.6 7.6 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EAK90427.1 - 0.21 12.1 6.9 0.35 11.3 0.1 3.3 3 0 0 3 3 3 0 AAA domain Sec62 PF03839.16 EAK90427.1 - 0.28 10.7 1.2 0.38 10.2 0.0 1.7 2 0 0 2 2 2 0 Translocation protein Sec62 TMEMspv1-c74-12 PF11044.8 EAK90428.1 - 0.004 17.1 0.9 0.012 15.6 0.9 1.8 1 0 0 1 1 1 1 Plectrovirus spv1-c74 ORF 12 transmembrane protein Big_5 PF13205.6 EAK90429.1 - 1.2e-12 48.5 0.1 1.3e-08 35.5 0.0 3.7 3 0 0 3 3 3 2 Bacterial Ig-like domain APP_N PF02177.16 EAK90429.1 - 0.054 13.9 0.5 0.43 11.0 0.0 2.9 2 0 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding Snf7 PF03357.21 EAK90430.1 - 8.1e-18 64.6 12.6 1.1e-17 64.2 12.6 1.2 1 0 0 1 1 1 1 Snf7 DUF5082 PF16888.5 EAK90430.1 - 0.0011 19.2 3.8 0.47 10.7 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF5082) IFT57 PF10498.9 EAK90430.1 - 0.037 13.0 8.0 0.064 12.2 8.0 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SPX PF03105.19 EAK90430.1 - 0.11 12.3 3.8 0.17 11.8 3.6 1.5 1 1 0 1 1 1 0 SPX domain YlqD PF11068.8 EAK90430.1 - 0.29 11.5 7.7 0.13 12.6 5.0 1.9 1 1 1 2 2 2 0 YlqD protein SOAR PF16533.5 EAK90430.1 - 0.43 10.6 10.3 1 9.4 0.6 2.7 2 1 1 3 3 3 0 STIM1 Orai1-activating region DUF3585 PF12130.8 EAK90430.1 - 0.47 10.6 11.5 0.32 11.1 6.4 2.2 1 1 1 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Spc24 PF08286.11 EAK90430.1 - 0.94 9.8 7.4 0.21 11.9 2.6 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 K-box PF01486.17 EAK90430.1 - 1.4 9.1 10.8 0.38 10.9 1.4 3.0 2 1 0 2 2 2 0 K-box region GPS2_interact PF15784.5 EAK90430.1 - 2.1 8.9 7.3 3 8.3 2.7 2.6 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain Fzo_mitofusin PF04799.13 EAK90430.1 - 5.9 6.4 7.6 1.8 8.1 1.7 2.2 1 1 1 2 2 2 0 fzo-like conserved region APG6_N PF17675.1 EAK90430.1 - 6.6 7.3 12.1 6.1 7.4 7.6 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region Methyltrn_RNA_3 PF02598.17 EAK90431.1 - 4.6e-95 318.4 0.0 5.6e-95 318.1 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.19 EAK90431.1 - 0.0012 19.1 0.0 0.024 14.8 0.0 2.7 3 0 0 3 3 3 1 SpoU rRNA Methylase family DEAD PF00270.29 EAK90432.1 - 3.9e-40 137.5 0.0 3.6e-39 134.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK90432.1 - 1.5e-32 112.2 0.4 1.9e-31 108.7 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK90432.1 - 1.1e-06 28.7 0.0 2.1e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-CCHC PF00098.23 EAK90432.1 - 0.35 11.0 3.4 0.64 10.2 3.4 1.5 1 0 0 1 1 1 0 Zinc knuckle Cyclin_N PF00134.23 EAK90433.1 - 4e-06 26.6 0.1 1.4e-05 24.8 0.1 1.8 1 1 0 1 1 1 1 Cyclin, N-terminal domain Alba PF01918.21 EAK90434.1 - 1.9e-19 69.2 0.1 3.5e-19 68.4 0.1 1.5 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 EAK90434.1 - 6.9e-14 52.0 0.3 6.9e-14 52.0 0.3 1.6 2 0 0 2 2 2 1 Rpp20 subunit of nuclear RNase MRP and P DUF5507 PF17612.2 EAK90434.1 - 0.017 14.9 0.2 0.025 14.3 0.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5507) GTA_holin_3TM PF11351.8 EAK90434.1 - 0.15 12.6 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Mucin PF01456.17 EAK90435.1 - 0.0018 18.3 29.3 0.017 15.1 25.7 2.2 2 0 0 2 2 2 2 Mucin-like glycoprotein Hydrolase_6 PF13344.6 EAK90435.1 - 0.0076 16.3 0.1 0.018 15.1 0.1 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF3439 PF11921.8 EAK90435.1 - 0.058 13.4 16.5 0.17 11.8 16.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Med3 PF11593.8 EAK90435.1 - 1.7 7.8 10.5 2.6 7.1 10.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RGS12_us1 PF16613.5 EAK90436.1 - 0.33 11.3 8.8 0.65 10.3 8.8 1.5 1 0 0 1 1 1 0 Unstructured region of RGS12 Shisa PF13908.6 EAK90438.1 - 0.0036 17.6 0.1 0.0036 17.6 0.1 3.5 2 1 1 3 3 3 1 Wnt and FGF inhibitory regulator DUF1449 PF07290.11 EAK90438.1 - 0.014 15.1 0.1 0.38 10.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1449) Adeno_E3_CR2 PF02439.15 EAK90438.1 - 4.8 7.0 7.1 6.9 6.5 7.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 AAA PF00004.29 EAK90439.1 - 5e-12 46.4 0.0 1.2e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EAK90439.1 - 5.4e-07 29.7 0.4 7.9e-06 25.9 0.0 3.0 4 1 0 4 4 4 1 Rad17 P-loop domain AAA_22 PF13401.6 EAK90439.1 - 0.00048 20.4 1.9 1.7 9.0 0.1 3.3 2 1 1 3 3 3 2 AAA domain AAA_18 PF13238.6 EAK90439.1 - 0.00094 19.7 0.6 0.0033 18.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_8 PF12780.7 EAK90439.1 - 0.0024 17.2 0.0 0.0052 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_16 PF13191.6 EAK90439.1 - 0.0044 17.4 0.1 0.015 15.7 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EAK90439.1 - 0.0059 16.6 0.0 0.029 14.4 0.0 2.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EAK90439.1 - 0.0091 16.5 1.2 0.023 15.2 0.1 2.2 2 0 0 2 2 2 1 ABC transporter dNK PF01712.19 EAK90439.1 - 0.014 15.3 2.9 0.025 14.4 0.5 2.8 2 1 0 2 2 2 0 Deoxynucleoside kinase AAA_5 PF07728.14 EAK90439.1 - 0.014 15.4 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 EAK90439.1 - 0.015 14.7 0.0 2.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_2 PF07724.14 EAK90439.1 - 0.034 14.3 0.0 0.074 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) SMC_ScpA PF02616.14 EAK90439.1 - 0.041 13.8 0.2 0.089 12.7 0.2 1.5 1 0 0 1 1 1 0 Segregation and condensation protein ScpA Cytidylate_kin PF02224.18 EAK90439.1 - 0.043 13.6 0.2 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase RsgA_GTPase PF03193.16 EAK90439.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_6 PF12774.7 EAK90439.1 - 0.057 12.4 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_33 PF13671.6 EAK90439.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EAK90439.1 - 0.18 11.5 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain C1_2 PF03107.16 EAK90440.1 - 0.19 12.1 8.0 2.2 8.7 5.4 2.3 2 0 0 2 2 2 0 C1 domain PHD PF00628.29 EAK90440.1 - 0.37 10.7 9.4 0.14 12.1 5.4 2.0 2 0 0 2 2 2 0 PHD-finger zf-RING_2 PF13639.6 EAK90440.1 - 0.67 10.3 12.5 2.7 8.4 12.6 1.8 1 1 1 2 2 2 0 Ring finger domain C1_1 PF00130.22 EAK90440.1 - 0.73 9.8 8.4 0.31 11.0 5.5 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 EAK90440.1 - 0.98 9.4 8.1 0.3 11.1 4.7 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 RINGv PF12906.7 EAK90440.1 - 1.4 9.1 11.0 3 8.0 10.3 1.9 1 1 1 2 2 2 0 RING-variant domain START PF01852.19 EAK90441.1 - 0.00069 19.1 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 START domain GDI PF00996.18 EAK90443.1 - 3.5e-34 118.1 6.3 4.3e-15 55.2 0.1 3.4 3 1 1 4 4 4 3 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EAK90443.1 - 0.03 14.6 0.0 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF4999 PF16390.5 EAK90443.1 - 0.048 13.9 0.0 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function HAGH_C PF16123.5 EAK90444.1 - 0.12 12.9 0.0 5.4 7.6 0.0 2.3 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus RNA_pol_Rpb6 PF01192.22 EAK90445.1 - 6.8e-18 64.3 0.1 1.3e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb6 GST_C_3 PF14497.6 EAK90446.1 - 0.0024 18.0 0.1 0.039 14.1 0.0 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain YpsA PF06908.11 EAK90446.1 - 0.063 13.3 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 YspA SLOG family S1-P1_nuclease PF02265.16 EAK90446.1 - 0.094 12.5 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 S1/P1 Nuclease PP2C PF00481.21 EAK90447.1 - 4.8e-06 26.4 0.0 0.067 12.8 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EAK90447.1 - 1.7e-05 24.9 0.0 0.0011 18.9 0.0 3.3 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) FAM104 PF15434.6 EAK90447.1 - 1.8 9.2 8.3 0.28 11.8 0.3 2.6 2 0 0 2 2 2 0 Family 104 PA14 PF07691.12 EAK90448.1 - 1.7e-26 92.8 0.0 3.4e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 EAK90448.1 - 0.00018 21.9 0.0 0.0009 19.6 0.0 2.2 2 0 0 2 2 2 1 GLEYA domain fn2 PF00040.19 EAK90448.1 - 0.011 16.0 2.3 0.011 16.0 2.3 1.8 2 0 0 2 2 2 0 Fibronectin type II domain FliJ PF02050.16 EAK90448.1 - 0.026 14.7 3.5 0.85 9.9 0.4 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein Exonuc_VII_L PF02601.15 EAK90448.1 - 0.043 13.4 0.5 0.074 12.6 0.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HSBP1 PF06825.12 EAK90448.1 - 1.1 9.2 4.6 2.9 7.8 1.1 3.0 2 1 1 3 3 3 0 Heat shock factor binding protein 1 DUF812 PF05667.11 EAK90448.1 - 6.3 5.6 8.7 0.2 10.5 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF812) MS_channel PF00924.18 EAK90449.1 - 5e-18 65.4 1.6 1.1e-17 64.3 1.6 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel DUF3464 PF11947.8 EAK90450.1 - 0.024 14.4 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Phosducin PF02114.16 EAK90451.1 - 4.8e-11 42.1 0.3 7e-11 41.6 0.3 1.3 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EAK90451.1 - 0.00075 19.5 0.1 0.0023 17.9 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin CDO_I PF05995.12 EAK90451.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Cysteine dioxygenase type I DUF1836 PF08876.11 EAK90452.1 - 0.13 12.4 7.7 0.035 14.1 2.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1836) zf-RING_2 PF13639.6 EAK90453.1 - 6.4e-12 45.6 4.9 6.4e-12 45.6 4.9 1.8 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 EAK90453.1 - 1.1e-09 37.8 3.5 3.3e-09 36.3 3.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EAK90453.1 - 1e-08 35.3 3.3 3.3e-08 33.7 3.3 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EAK90453.1 - 1.7e-07 30.9 4.1 3.7e-07 29.9 4.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAK90453.1 - 1.7e-06 27.8 4.5 4.2e-06 26.5 4.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK90453.1 - 3.1e-06 27.1 4.4 7.5e-06 25.9 4.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAK90453.1 - 1.3e-05 25.0 3.3 3e-05 23.9 3.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_1 PF14446.6 EAK90453.1 - 0.00013 21.9 3.2 0.00037 20.3 0.4 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-C3HC4_3 PF13920.6 EAK90453.1 - 0.0016 18.2 2.1 0.0036 17.1 2.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EAK90453.1 - 0.026 14.1 1.9 0.026 14.1 1.9 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EAK90453.1 - 0.027 14.3 2.9 0.052 13.4 2.9 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EAK90453.1 - 0.033 14.0 2.8 0.07 12.9 2.8 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EAK90453.1 - 0.047 13.7 2.7 0.15 12.2 2.7 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 EAK90453.1 - 0.15 12.2 1.3 0.27 11.4 1.3 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger FtsL PF04999.13 EAK90453.1 - 0.21 11.6 1.4 0.24 11.4 0.1 1.7 2 0 0 2 2 2 0 Cell division protein FtsL FANCL_C PF11793.8 EAK90453.1 - 0.21 11.8 4.4 1.1 9.5 4.4 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Voltage_CLC PF00654.20 EAK90453.1 - 0.59 9.3 3.3 1.1 8.4 3.3 1.4 1 1 0 1 1 1 0 Voltage gated chloride channel UCH PF00443.29 EAK90454.1 - 1.2e-18 67.6 12.1 1.2e-18 67.6 12.1 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EAK90454.1 - 0.00055 19.6 15.4 0.0009 18.9 12.3 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Alg14 PF08660.11 EAK90456.1 - 4.7e-35 121.1 0.0 5.9e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like 2Fe-2S_thioredx PF01257.19 EAK90456.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin Aldedh PF00171.22 EAK90457.1 - 8.2e-15 54.3 0.0 4.4e-09 35.4 0.0 2.3 2 1 0 2 2 2 2 Aldehyde dehydrogenase family HTH_57 PF18679.1 EAK90457.1 - 0.12 12.7 0.0 0.66 10.3 0.0 2.2 2 0 0 2 2 2 0 ThcOx helix turn helix domain Fumble PF03630.14 EAK90458.1 - 1.7e-44 152.4 5.2 2.1e-44 152.0 5.2 1.1 1 0 0 1 1 1 1 Fumble DUF3924 PF13062.6 EAK90458.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3924) zf-RING_4 PF14570.6 EAK90459.1 - 4e-20 71.3 16.7 1.2e-19 69.8 16.7 1.9 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EAK90459.1 - 7.6e-09 35.3 0.1 1.9e-08 34.0 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EAK90459.1 - 5.3e-07 29.4 9.6 1.5e-06 28.0 9.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EAK90459.1 - 0.0027 18.0 11.6 0.0085 16.4 11.6 2.0 1 0 0 1 1 1 1 Ring finger domain RRM_5 PF13893.6 EAK90459.1 - 0.0077 15.8 0.1 0.019 14.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 EAK90459.1 - 0.031 14.1 0.2 1.9 8.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Prok-RING_4 PF14447.6 EAK90459.1 - 0.068 13.0 8.7 2.9 7.8 9.4 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EAK90459.1 - 7.6 6.5 12.9 23 4.9 12.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EF-hand_13 PF17958.1 EAK90460.1 - 7.6e-12 44.9 0.6 6.2e-11 42.0 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 EAK90460.1 - 2.1e-10 40.9 14.5 8.5e-09 35.7 10.7 3.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EAK90460.1 - 1.7e-05 24.4 4.4 0.0076 16.1 0.2 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EAK90460.1 - 0.0051 16.3 6.1 1.5 8.6 0.2 4.3 4 0 0 4 4 4 2 EF hand HECT PF00632.25 EAK90462.1 - 1.2e-41 143.3 0.0 3.7e-41 141.6 0.0 1.9 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank_4 PF13637.6 EAK90462.1 - 9e-07 29.3 0.1 0.034 14.7 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAK90462.1 - 2.1e-06 28.2 0.1 0.0088 16.6 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EAK90462.1 - 0.0046 17.3 0.4 0.92 10.1 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EAK90462.1 - 0.013 15.9 0.1 4.4 8.2 0.0 3.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EAK90462.1 - 0.042 14.2 0.1 0.38 11.1 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) ubiquitin PF00240.23 EAK90463.1 - 9.8e-09 34.9 0.0 1.8e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 EAK90463.1 - 0.00032 20.6 4.1 0.00032 20.6 4.1 3.4 3 1 1 4 4 4 2 STI1 domain UBA PF00627.31 EAK90463.1 - 0.00052 19.9 0.0 0.0017 18.2 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EAK90463.1 - 0.0017 18.2 0.0 0.0036 17.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like GerD PF17898.1 EAK90463.1 - 0.0025 17.7 0.3 0.0076 16.2 0.3 1.8 1 0 0 1 1 1 1 Spore germination GerD central core domain HOIP-UBA PF16678.5 EAK90463.1 - 0.018 15.1 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair XPC-binding PF09280.11 EAK90463.1 - 1.8 8.4 12.7 0.36 10.6 0.5 4.0 3 1 1 4 4 4 0 XPC-binding domain Rgp1 PF08737.10 EAK90464.1 - 5.6e-10 39.0 8.7 4.1e-08 32.8 0.8 2.3 2 0 0 2 2 2 2 Rgp1 Arrestin_N PF00339.29 EAK90464.1 - 0.72 9.9 4.1 0.19 11.8 0.2 2.0 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain Ribophorin_II PF05817.14 EAK90466.1 - 2.5e-10 39.6 15.0 2e-09 36.6 8.4 2.2 2 0 0 2 2 2 2 Oligosaccharyltransferase subunit Ribophorin II Thioredoxin PF00085.20 EAK90467.1 - 4.7e-24 84.3 1.2 1.3e-15 57.3 0.3 3.0 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EAK90467.1 - 3.2e-15 56.5 9.8 5e-10 39.6 0.1 4.4 2 1 2 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EAK90467.1 - 5e-06 26.1 2.5 0.0005 19.5 0.6 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EAK90467.1 - 8.1e-06 25.8 0.2 0.016 15.1 0.1 2.8 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_2 PF13098.6 EAK90467.1 - 1.1e-05 25.8 2.4 0.013 15.9 0.3 3.9 3 1 0 3 3 3 1 Thioredoxin-like domain DUF836 PF05768.14 EAK90467.1 - 2.3e-05 24.7 0.9 0.03 14.7 0.5 2.7 2 0 0 2 2 2 2 Glutaredoxin-like domain (DUF836) Thioredoxin_5 PF13743.6 EAK90467.1 - 0.0016 18.2 0.1 3 7.5 0.0 3.5 3 0 0 3 3 3 1 Thioredoxin TraF PF13728.6 EAK90467.1 - 0.024 14.5 0.1 0.095 12.5 0.0 2.0 3 0 0 3 3 3 0 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 EAK90467.1 - 0.068 12.9 0.5 0.89 9.3 0.0 2.5 2 1 0 2 2 2 0 Thioredoxin Redoxin PF08534.10 EAK90467.1 - 0.16 11.7 0.0 5.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Redoxin DUF5381 PF17353.2 EAK90468.1 - 0.06 13.1 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5381) VASt PF16016.5 EAK90469.1 - 0.0088 16.5 0.3 0.0088 16.5 0.3 2.7 3 1 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 EAK90471.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 PH domain CBM_14 PF01607.24 EAK90472.1 - 6.3e-05 23.1 54.5 0.12 12.6 3.0 12.2 4 4 9 13 13 13 7 Chitin binding Peritrophin-A domain DUF2971 PF11185.8 EAK90472.1 - 0.077 14.2 2.4 21 6.4 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2971) cEGF PF12662.7 EAK90472.1 - 0.83 9.6 19.1 3.9 7.5 0.1 6.7 7 0 0 7 7 7 0 Complement Clr-like EGF-like dUTPase PF00692.19 EAK90473.1 - 3.7e-15 55.7 0.0 4.9e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 dUTPase JAB PF01398.21 EAK90474.1 - 0.00012 22.0 0.1 0.41 10.6 0.0 2.7 2 0 0 2 2 2 2 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Adeno_shaft PF00608.17 EAK90474.1 - 0.12 12.2 1.0 0.24 11.3 0.2 2.0 2 0 0 2 2 2 0 Adenoviral fibre protein (repeat/shaft region) Bromodomain PF00439.25 EAK90477.1 - 6.7e-19 67.8 0.2 2.7e-18 65.8 0.0 2.1 2 0 0 2 2 2 1 Bromodomain RRM_1 PF00076.22 EAK90478.1 - 4.7e-29 100.0 2.2 9e-14 51.1 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAK90478.1 - 4e-05 23.2 0.4 0.087 12.4 0.0 2.6 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EAK90478.1 - 0.00022 22.3 2.1 0.00022 22.3 2.1 2.5 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EAK90478.1 - 0.00024 20.9 0.5 2.5 8.0 0.0 4.0 3 2 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EAK90478.1 - 0.011 15.8 0.4 0.081 13.0 0.0 2.5 2 1 0 2 2 2 0 RNA binding motif LPD7 PF18821.1 EAK90478.1 - 0.11 12.6 0.0 0.39 10.9 0.0 1.9 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 7 DUF5344 PF17279.2 EAK90478.1 - 5.8 7.6 8.6 8.2 7.1 0.2 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5344) ETRAMP PF09716.10 EAK90479.1 - 0.55 10.3 5.1 14 5.8 0.1 3.3 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Sec3-PIP2_bind PF15277.6 EAK90480.1 - 0.015 15.4 0.6 0.051 13.7 0.2 2.2 2 0 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH Rtt106 PF08512.12 EAK90481.1 - 4.4e-25 87.9 0.3 4.7e-23 81.4 0.0 2.5 2 0 0 2 2 2 1 Histone chaperone Rttp106-like POB3_N PF17292.2 EAK90481.1 - 8e-24 83.9 0.3 5.4e-20 71.6 0.1 2.6 2 0 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 EAK90481.1 - 4.7e-15 55.2 0.3 1.4e-14 53.7 0.0 1.9 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) WD40_like PF17005.5 EAK90481.1 - 0.012 14.9 0.3 0.019 14.3 0.3 1.2 1 0 0 1 1 1 0 WD40-like domain DUF515 PF04415.12 EAK90481.1 - 0.36 9.2 0.0 0.36 9.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF515) Pex14_N PF04695.13 EAK90481.1 - 0.76 10.4 4.2 1.3 9.6 4.2 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cwf_Cwc_15 PF04889.12 EAK90481.1 - 3.5 7.3 22.3 5.1 6.8 22.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EAK90481.1 - 7.4 5.8 16.5 12 5.1 16.5 1.3 1 0 0 1 1 1 0 NOA36 protein Hint PF01079.20 EAK90482.1 - 2.1e-23 83.0 0.0 3.3e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.6 EAK90482.1 - 7.2e-05 23.1 0.0 0.0012 19.1 0.0 2.3 2 0 0 2 2 2 1 Hint domain DUF1317 PF07026.11 EAK90482.1 - 0.053 13.3 0.2 0.13 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1317) DNA_ligase_OB PF03120.16 EAK90482.1 - 0.18 11.7 0.3 3 7.8 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent DNA ligase OB-fold domain PPTA PF01239.22 EAK90483.1 - 1e-28 98.1 18.3 1.5e-07 30.9 0.7 6.1 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_17 PF13431.6 EAK90483.1 - 0.11 12.9 0.2 1 9.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat FYVE PF01363.21 EAK90484.1 - 3.5 7.8 13.3 1 9.5 8.5 2.4 1 1 1 2 2 2 0 FYVE zinc finger OmpH PF03938.14 EAK90485.1 - 1.6 9.1 23.3 0.51 10.7 8.3 2.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DHHC PF01529.20 EAK90485.1 - 3.9 7.6 16.5 0.65 10.1 1.0 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase AKAP7_NLS PF10469.9 EAK90487.1 - 4.3e-30 105.1 1.4 6.9e-30 104.5 1.4 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain LigT_PEase PF02834.16 EAK90487.1 - 1.4e-05 25.2 0.0 0.072 13.3 0.2 3.4 2 1 0 2 2 2 1 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 EAK90487.1 - 6.2e-05 22.9 0.0 0.00053 19.9 0.0 2.2 1 1 1 2 2 2 1 2'-5' RNA ligase superfamily WD40 PF00400.32 EAK90489.1 - 7.2e-16 58.3 6.5 0.013 16.4 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK90489.1 - 1.4e-10 41.3 0.3 0.024 14.9 0.0 5.1 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EAK90489.1 - 0.075 12.0 0.0 5.4 5.9 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Adipogenin PF15202.6 EAK90490.1 - 0.13 12.3 0.1 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Adipogenin DUF5542 PF17696.1 EAK90490.1 - 0.55 10.4 0.1 0.55 10.4 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5542) SAE2 PF08573.10 EAK90492.1 - 7.4e-06 27.0 13.1 0.0003 21.9 10.0 3.2 2 1 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus APC_N_CC PF16689.5 EAK90492.1 - 0.22 11.6 2.7 0.34 11.0 0.8 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain PikAIV_N PF18605.1 EAK90492.1 - 0.24 11.0 4.1 0.61 9.7 4.1 1.7 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain CCDC92 PF14916.6 EAK90492.1 - 0.31 10.8 3.5 0.26 11.1 0.7 2.2 2 0 0 2 2 2 0 Coiled-coil domain of unknown function RMI1_N PF08585.12 EAK90493.1 - 1.3e-10 41.4 0.8 7.6e-09 35.6 0.6 3.0 1 1 0 1 1 1 1 RecQ mediated genome instability protein Dynein_AAA_lid PF17852.1 EAK90494.1 - 0.14 12.2 2.1 32 4.6 0.1 4.2 3 0 0 3 3 3 0 Dynein heavy chain AAA lid domain DUF4834 PF16118.5 EAK90495.1 - 1.4 10.0 8.5 39 5.3 4.6 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF5383 PF17355.2 EAK90495.1 - 6 7.3 8.2 1.1 9.6 3.4 2.5 2 2 0 2 2 2 0 Family of unknown function (DUF5383) Vps16_N PF04841.13 EAK90497.1 - 5.2e-38 130.9 0.0 1.2e-37 129.7 0.0 1.6 1 1 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EAK90497.1 - 1.5e-18 66.9 6.9 1.9e-09 37.1 0.9 2.8 1 1 1 2 2 2 2 Vps16, C-terminal region PilO PF04350.13 EAK90498.1 - 1.2 9.3 4.0 1.7 8.8 0.1 3.1 3 0 0 3 3 3 0 Pilus assembly protein, PilO GPS PF01825.21 EAK90500.1 - 0.05 14.1 1.0 0.14 12.7 1.0 1.7 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif Val_tRNA-synt_C PF10458.9 EAK90501.1 - 0.095 13.0 0.6 0.095 13.0 0.6 2.4 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DIT1_PvcA PF05141.12 EAK90501.1 - 0.095 12.1 4.6 0.11 11.9 4.2 1.3 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein DUF919 PF06034.11 EAK90501.1 - 2.1 8.3 9.7 1.2 9.0 2.9 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2436 PF10365.9 EAK90503.1 - 0.14 11.9 0.1 0.34 10.7 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2436) CTP_transf_1 PF01148.20 EAK90504.1 - 1e-70 238.6 15.3 1.4e-70 238.1 15.3 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family CitMHS PF03600.16 EAK90504.1 - 2.9 7.0 12.0 1.1 8.4 1.9 3.0 2 1 1 3 3 3 0 Citrate transporter DUF3464 PF11947.8 EAK90505.1 - 0.013 15.2 1.3 0.013 15.2 1.3 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Jagunal PF07086.12 EAK90505.1 - 0.024 14.7 6.8 0.033 14.3 6.8 1.2 1 0 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis Tetraspanin PF00335.20 EAK90505.1 - 0.034 13.9 10.1 0.49 10.1 10.0 2.2 1 1 0 1 1 1 0 Tetraspanin family PHO4 PF01384.20 EAK90505.1 - 0.069 12.2 1.8 0.082 11.9 1.8 1.1 1 0 0 1 1 1 0 Phosphate transporter family TB2_DP1_HVA22 PF03134.19 EAK90505.1 - 5.4 7.0 9.4 0.57 10.2 3.1 2.4 1 1 2 3 3 3 0 TB2/DP1, HVA22 family DUF3915 PF13054.6 EAK90506.1 - 0.34 10.9 1.9 0.8 9.7 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Pox_EPC_I2-L1 PF12575.8 EAK90507.1 - 0.045 14.0 0.0 0.24 11.6 0.0 2.4 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF1189 PF06691.11 EAK90508.1 - 0.033 13.7 2.8 0.04 13.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) CD24 PF14984.6 EAK90508.1 - 0.047 13.9 0.2 0.08 13.2 0.2 1.4 1 0 0 1 1 1 0 CD24 protein DUF4131 PF13567.6 EAK90508.1 - 0.1 12.2 0.8 0.16 11.6 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Hat1_N PF10394.9 EAK90509.1 - 8.5e-20 71.6 1.2 3.8e-19 69.5 0.6 2.2 2 1 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus MOZ_SAS PF01853.18 EAK90509.1 - 0.071 12.8 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 MOZ/SAS family DUF148 PF02520.17 EAK90509.1 - 0.11 12.7 0.4 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF148 Acetyltransf_10 PF13673.7 EAK90509.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-C3HC4_3 PF13920.6 EAK90510.1 - 4.3e-06 26.5 9.4 4.3e-06 26.5 9.4 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) ADD_DNMT3 PF17980.1 EAK90510.1 - 0.088 12.8 10.2 0.42 10.6 7.6 2.4 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 ATP_bind_1 PF03029.17 EAK90511.1 - 3.3e-71 239.9 0.0 3.8e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 EAK90511.1 - 0.00049 20.3 0.0 0.0006 20.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EAK90511.1 - 0.0048 16.3 0.7 2.2 7.7 0.0 3.0 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 EAK90511.1 - 0.01 15.8 0.0 0.19 11.7 0.0 2.2 2 0 0 2 2 2 1 NTPase cobW PF02492.19 EAK90511.1 - 0.011 15.4 0.0 0.082 12.5 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EAK90511.1 - 0.017 14.9 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EAK90511.1 - 0.018 15.5 0.0 0.041 14.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EAK90511.1 - 0.021 15.1 0.0 0.71 10.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EAK90511.1 - 0.025 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EAK90511.1 - 0.025 15.0 0.0 0.061 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 EAK90511.1 - 0.028 14.2 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EAK90511.1 - 0.031 14.4 0.1 0.43 10.7 0.1 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EAK90511.1 - 0.04 14.5 0.0 0.074 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EAK90511.1 - 0.075 13.4 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EAK90511.1 - 0.08 12.7 0.0 0.85 9.4 0.0 2.1 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_29 PF13555.6 EAK90511.1 - 0.086 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EAK90511.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain KTI12 PF08433.10 EAK90511.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Sigma54_activat PF00158.26 EAK90511.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EAK90511.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 EAK90511.1 - 0.18 11.5 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sortilin-Vps10 PF15902.5 EAK90512.1 - 1.2e-95 320.9 14.0 5.8e-95 318.7 14.0 1.9 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EAK90512.1 - 4.6e-37 128.0 0.7 8.6e-37 127.1 0.7 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EAK90512.1 - 0.00095 18.8 15.3 0.72 10.1 0.1 7.0 7 0 0 7 7 7 2 BNR/Asp-box repeat BNR_6 PF15899.5 EAK90512.1 - 0.019 14.9 0.0 0.19 11.8 0.1 2.8 2 0 0 2 2 2 0 BNR-Asp box repeat UCR_UQCRX_QCR9 PF05365.12 EAK90512.1 - 0.24 11.4 2.1 0.88 9.6 0.2 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like SprT-like PF10263.9 EAK90513.1 - 3.6e-18 65.5 0.0 7.5e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 EAK90513.1 - 0.0092 15.9 1.8 0.0092 15.9 1.8 2.5 2 0 0 2 2 2 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EAK90513.1 - 0.011 15.8 0.5 0.027 14.6 0.5 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Chordopox_G3 PF06129.12 EAK90513.1 - 0.2 12.4 1.9 0.64 10.8 0.6 2.3 2 0 0 2 2 2 0 Chordopoxvirus G3 protein FKBP_C PF00254.28 EAK90516.1 - 8.7e-26 90.1 0.0 4.2e-25 87.9 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase cwf18 PF08315.12 EAK90516.1 - 0.072 13.8 2.5 0.11 13.2 2.5 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor OTU PF02338.19 EAK90517.1 - 0.018 15.6 0.0 0.06 13.8 0.0 2.0 1 1 0 1 1 1 0 OTU-like cysteine protease RNase_PH PF01138.21 EAK90518.1 - 1.3e-08 35.4 0.1 2.3e-08 34.6 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EAK90518.1 - 0.0012 18.9 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 NPC1_N PF16414.5 EAK90518.1 - 0.17 11.4 4.3 5.3 6.5 0.3 2.2 2 0 0 2 2 2 0 Niemann-Pick C1 N terminus UTP25 PF06862.12 EAK90520.1 - 3.6e-106 355.8 0.0 8.8e-106 354.5 0.0 1.5 1 1 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Amino_oxidase PF01593.24 EAK90521.1 - 1.9e-24 86.8 0.0 3.1e-09 36.6 0.0 3.2 3 0 0 3 3 3 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EAK90521.1 - 6.8e-07 29.4 0.0 1.7e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EAK90521.1 - 8.6e-05 21.9 0.0 0.00021 20.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EAK90521.1 - 0.00013 21.4 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EAK90521.1 - 0.00029 20.5 0.0 0.00053 19.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EAK90521.1 - 0.0011 18.2 0.1 0.0016 17.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EAK90521.1 - 0.0011 18.2 0.1 0.002 17.4 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EAK90521.1 - 0.0011 17.7 0.1 0.002 16.9 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EAK90521.1 - 0.0034 16.7 0.1 0.0054 16.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EAK90521.1 - 0.0043 16.1 0.0 0.0068 15.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EAK90521.1 - 0.011 16.3 0.0 0.026 15.1 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EAK90521.1 - 0.071 12.2 0.6 0.15 11.1 0.2 1.8 1 1 1 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EAK90521.1 - 0.079 12.9 0.0 0.35 10.9 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EAK90521.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EAK90521.1 - 0.15 11.4 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase LCCL PF03815.19 EAK90522.1 - 8.6e-19 67.5 0.1 8.6e-19 67.5 0.1 3.0 2 0 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.25 EAK90522.1 - 7.4e-12 45.5 1.2 2.3e-06 27.7 0.6 2.6 2 0 0 2 2 2 2 F5/8 type C domain DUF1080 PF06439.11 EAK90522.1 - 0.0008 19.6 1.6 0.009 16.1 0.0 2.9 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1080) Rxt3 PF08642.10 EAK90522.1 - 0.11 13.3 0.1 0.78 10.5 0.1 2.3 1 1 1 2 2 2 0 Histone deacetylation protein Rxt3 Rad21_Rec8_N PF04825.13 EAK90523.1 - 4.8e-17 62.1 0.1 1.4e-16 60.6 0.1 1.8 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EAK90523.1 - 1.8e-06 27.1 0.0 4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 EAK90523.1 - 0.022 14.7 0.0 0.059 13.3 0.0 1.7 1 0 0 1 1 1 0 Segregation and condensation protein ScpA AAA_18 PF13238.6 EAK90524.1 - 2.5e-06 28.1 1.5 5.9e-06 26.8 0.6 2.2 2 1 0 2 2 1 1 AAA domain Zeta_toxin PF06414.12 EAK90524.1 - 2.1e-05 23.9 0.1 0.00017 20.9 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EAK90524.1 - 3.4e-05 24.0 0.1 7.1e-05 23.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 EAK90524.1 - 0.00041 20.1 1.2 0.0016 18.2 1.2 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 EAK90524.1 - 0.0014 18.4 0.2 0.0048 16.6 0.2 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain dNK PF01712.19 EAK90524.1 - 0.0018 18.2 6.6 0.0018 18.2 6.6 1.8 2 0 0 2 2 2 1 Deoxynucleoside kinase APS_kinase PF01583.20 EAK90524.1 - 0.0063 16.4 0.0 0.016 15.1 0.0 1.6 2 0 0 2 2 2 1 Adenylylsulphate kinase Cytidylate_kin PF02224.18 EAK90524.1 - 0.0097 15.7 1.8 0.043 13.5 1.8 2.2 1 1 0 1 1 1 1 Cytidylate kinase AAA_17 PF13207.6 EAK90524.1 - 0.01 16.2 0.1 0.055 13.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EAK90524.1 - 0.011 16.0 0.1 0.018 15.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 EAK90524.1 - 0.016 15.3 0.5 0.037 14.1 0.5 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 EAK90524.1 - 0.018 15.5 0.8 0.035 14.6 0.8 1.7 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EAK90524.1 - 0.026 14.9 0.1 0.061 13.7 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain Ploopntkinase2 PF18747.1 EAK90524.1 - 0.037 13.3 0.6 0.1 11.8 0.4 1.7 1 1 0 1 1 1 0 P-loop Nucleotide Kinase2 RsgA_GTPase PF03193.16 EAK90524.1 - 0.042 13.7 0.2 0.13 12.2 0.2 1.8 1 1 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EAK90524.1 - 0.049 13.9 0.8 0.28 11.5 0.8 2.3 1 1 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 EAK90524.1 - 0.052 13.7 0.7 0.12 12.5 0.2 1.9 2 0 0 2 2 1 0 Cytidylate kinase-like family FtsK_SpoIIIE PF01580.18 EAK90524.1 - 0.053 12.9 0.0 0.099 12.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family SKI PF01202.22 EAK90524.1 - 0.061 13.4 0.5 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase AAA_5 PF07728.14 EAK90524.1 - 0.064 13.2 0.1 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CoaE PF01121.20 EAK90524.1 - 0.081 12.6 0.1 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Dephospho-CoA kinase RNA_helicase PF00910.22 EAK90524.1 - 0.092 13.1 2.6 0.25 11.8 1.5 2.4 2 1 0 2 2 2 0 RNA helicase SRP54 PF00448.22 EAK90524.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 EAK90524.1 - 0.12 11.4 1.1 0.3 10.1 0.8 1.9 1 1 1 2 2 2 0 Type II/IV secretion system protein CPT PF07931.12 EAK90524.1 - 0.13 12.1 0.2 0.25 11.1 0.2 1.7 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.6 EAK90524.1 - 0.23 11.0 0.1 0.54 9.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EAK90524.1 - 0.54 10.2 3.9 4.4 7.2 0.3 2.6 1 1 0 2 2 2 0 NTPase BORCS7 PF16088.5 EAK90524.1 - 0.56 10.5 5.2 8.3 6.7 0.1 3.0 2 1 1 3 3 3 0 BLOC-1-related complex sub-unit 7 Ribosomal_L18A PF01775.17 EAK90525.1 - 4.2e-49 165.7 1.2 5.2e-49 165.4 1.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A GLE1 PF07817.13 EAK90526.1 - 6.1e-22 78.1 0.3 6.1e-22 78.1 0.3 2.5 2 1 0 2 2 2 1 GLE1-like protein AF2331-like PF14556.6 EAK90526.1 - 0.059 13.9 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 AF2331-like DUF3523 PF12037.8 EAK90526.1 - 2.7 7.3 39.0 4.1 6.7 39.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) GRASP55_65 PF04495.14 EAK90527.1 - 1.4e-33 116.2 0.0 5.8e-27 94.7 0.0 2.5 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PDZ PF00595.24 EAK90527.1 - 0.0023 18.2 0.0 1.1 9.7 0.1 3.1 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 EAK90527.1 - 0.0024 18.2 0.2 0.011 16.0 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 EAK90527.1 - 0.061 13.2 0.0 9.9 6.1 0.0 2.5 2 0 0 2 2 2 0 PDZ domain HSP70 PF00012.20 EAK90529.1 - 8.3e-256 849.9 13.0 9.5e-256 849.7 13.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EAK90529.1 - 3.6e-17 62.2 3.1 2.6e-16 59.3 2.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EAK90529.1 - 0.001 19.4 5.8 0.65 10.5 0.1 3.8 3 2 0 3 3 3 1 Cell division protein FtsA Hydantoinase_A PF01968.18 EAK90529.1 - 0.065 12.5 0.6 1.8 7.8 0.1 2.8 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase FIVAR PF07554.13 EAK90529.1 - 0.084 13.6 1.3 0.38 11.5 0.1 2.7 3 0 0 3 3 3 0 FIVAR domain StbA PF06406.11 EAK90529.1 - 0.25 10.5 3.2 0.31 10.3 0.2 2.4 2 1 0 2 2 2 0 StbA protein Effector_1 PF04518.12 EAK90529.1 - 0.8 8.8 4.5 1.3 8.1 0.2 2.2 2 0 0 2 2 2 0 Effector from type III secretion system Cytochrom_B562 PF07361.11 EAK90529.1 - 1.2 9.9 8.7 4.8 7.9 5.0 2.7 2 0 0 2 2 2 0 Cytochrome b562 VSG_B PF13206.6 EAK90529.1 - 1.7 7.8 6.2 0.3 10.3 2.1 1.7 2 0 0 2 2 2 0 Trypanosomal VSG domain CdiI_2 PF18593.1 EAK90529.1 - 2.3 8.9 6.5 2.8 8.7 1.5 3.0 1 1 1 2 2 2 0 CdiI immunity protein DUF357 PF04010.13 EAK90529.1 - 2.5 8.2 4.5 17 5.6 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF357) Hydrolase_4 PF12146.8 EAK90530.1 - 5e-13 48.9 0.0 1.5e-08 34.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EAK90530.1 - 1.3e-08 34.8 0.0 3.3e-05 23.6 0.0 2.3 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 EAK90530.1 - 2.4e-06 27.4 0.4 0.0037 16.9 0.2 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 EAK90530.1 - 1.3e-05 25.0 0.0 3.7e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) PhoPQ_related PF10142.9 EAK90530.1 - 2e-05 23.4 0.1 4.2e-05 22.4 0.1 1.4 2 0 0 2 2 2 1 PhoPQ-activated pathogenicity-related protein Abhydrolase_6 PF12697.7 EAK90530.1 - 0.00024 21.8 0.0 0.00035 21.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EAK90530.1 - 0.0053 16.2 0.1 0.04 13.4 0.1 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family PAF-AH_p_II PF03403.13 EAK90530.1 - 0.048 12.2 0.0 0.28 9.7 0.0 2.0 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II AXE1 PF05448.12 EAK90530.1 - 0.056 12.1 0.0 0.3 9.7 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 EAK90530.1 - 0.089 12.7 0.0 0.41 10.5 0.0 1.9 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal SNF2_N PF00176.23 EAK90533.1 - 2e-44 151.8 5.1 6.5e-41 140.2 0.0 3.1 3 0 0 3 3 3 2 SNF2 family N-terminal domain zf-RING_2 PF13639.6 EAK90533.1 - 1.8e-06 28.1 8.2 1.8e-06 28.1 8.2 3.5 3 0 0 3 3 3 1 Ring finger domain Helicase_C PF00271.31 EAK90533.1 - 2.9e-06 27.6 0.3 2.9e-06 27.6 0.3 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EAK90533.1 - 8.6e-05 22.4 7.7 8.6e-05 22.4 7.7 2.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_4 PF14570.6 EAK90533.1 - 9.5e-05 22.1 6.7 9.5e-05 22.1 6.7 2.4 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EAK90533.1 - 0.0001 22.3 6.6 0.00037 20.5 6.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EAK90533.1 - 0.00041 19.8 6.3 0.00041 19.8 6.3 6.9 5 2 0 5 5 5 1 Rtf2 RING-finger zf-C3HC4 PF00097.25 EAK90533.1 - 0.00046 20.0 11.0 0.00046 20.0 11.0 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EAK90533.1 - 0.01 15.7 16.3 0.021 14.7 11.8 3.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EAK90533.1 - 1.2 9.4 10.5 1.1 9.4 6.4 3.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 E1-E2_ATPase PF00122.20 EAK90534.1 - 3.9e-17 62.4 0.4 3.9e-17 62.4 0.4 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EAK90534.1 - 4.7e-13 49.9 0.1 1.4e-06 28.7 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EAK90534.1 - 6.5e-08 32.6 0.0 8.4e-07 29.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) PUB_1 PF18486.1 EAK90534.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 PNGase/UBA- or UBX-containing domain SSrecog PF03531.14 EAK90535.1 - 0.042 13.8 1.9 0.6 10.1 0.1 2.4 2 0 0 2 2 2 0 Structure-specific recognition protein (SSRP1) DUF334 PF03904.13 EAK90535.1 - 7.9 6.0 10.5 0.58 9.7 4.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF334) RPAP2_Rtr1 PF04181.13 EAK90536.1 - 6.9e-12 45.5 0.2 6.9e-12 45.5 0.2 3.0 4 0 0 4 4 4 1 Rtr1/RPAP2 family Caldesmon PF02029.15 EAK90536.1 - 4.4e-05 22.4 0.1 4.4e-05 22.4 0.1 2.1 1 1 1 2 2 2 1 Caldesmon Pro_isomerase PF00160.21 EAK90537.1 - 6.2e-50 169.6 0.0 1.7e-49 168.2 0.0 1.8 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EAK90537.1 - 7.7e-07 29.7 0.0 0.27 12.2 0.1 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EAK90537.1 - 0.00024 20.2 0.0 0.0087 15.1 0.0 2.5 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EAK90537.1 - 0.0079 16.5 0.1 3.4 8.0 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PIG-U PF06728.13 EAK90538.1 - 3.3e-54 184.4 54.3 4e-54 184.1 54.3 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Herpes_UL92 PF03048.14 EAK90538.1 - 0.046 13.5 0.7 0.1 12.4 0.7 1.5 1 0 0 1 1 1 0 UL92 family DUF3099 PF11298.8 EAK90539.1 - 0.13 12.4 2.0 2.2 8.5 0.2 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3099) TPR_1 PF00515.28 EAK90540.1 - 1e-06 28.3 2.6 4.6e-05 23.1 0.1 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EAK90540.1 - 2.3e-05 24.2 0.6 0.0069 16.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 EAK90540.1 - 0.00026 19.9 0.7 0.00035 19.4 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_17 PF13431.6 EAK90540.1 - 0.022 15.1 2.9 2.5 8.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EAK90540.1 - 0.031 14.4 3.8 0.88 9.7 1.5 3.1 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EAK90540.1 - 0.051 13.6 4.0 0.28 11.3 0.4 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF3552 PF12072.8 EAK90540.1 - 0.16 11.3 5.9 0.28 10.6 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF919 PF06034.11 EAK90540.1 - 0.71 9.8 5.2 1.8 8.5 5.2 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Pkinase_Tyr PF07714.17 EAK90543.1 - 0.00017 21.0 0.0 0.00021 20.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EAK90543.1 - 0.00034 20.1 0.2 0.0005 19.5 0.2 1.3 1 1 0 1 1 1 1 Protein kinase domain SLC3A2_N PF16028.5 EAK90543.1 - 0.043 13.4 0.1 0.082 12.5 0.1 1.5 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus UPF0242 PF06785.11 EAK90544.1 - 6.1 6.9 8.2 0.56 10.3 1.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CRAL_TRIO PF00650.20 EAK90545.1 - 2.1e-28 99.1 0.4 3.7e-28 98.2 0.4 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain Methyltransf_11 PF08241.12 EAK90546.1 - 1.3e-13 51.4 0.1 6e-13 49.3 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAK90546.1 - 1.4e-12 48.1 0.1 3e-12 47.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAK90546.1 - 2.4e-08 34.0 0.0 4e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAK90546.1 - 4.4e-08 33.8 0.0 8.7e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAK90546.1 - 4.7e-06 26.5 0.1 1e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 EAK90546.1 - 0.0017 18.0 0.0 0.0031 17.2 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 EAK90546.1 - 0.0034 16.4 0.0 0.014 14.3 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.11 EAK90546.1 - 0.0099 15.5 0.0 0.026 14.1 0.0 1.7 2 0 0 2 2 2 1 Nodulation protein S (NodS) CMAS PF02353.20 EAK90546.1 - 0.035 13.4 0.0 0.11 11.8 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase TRAF_BIRC3_bd PF16673.5 EAK90546.1 - 0.37 10.6 2.3 9.6 6.1 0.0 3.3 3 1 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain HA2 PF04408.23 EAK90547.1 - 3.8e-22 78.6 0.0 1.3e-21 76.9 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EAK90547.1 - 1.2e-12 48.0 0.1 2.7e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EAK90547.1 - 6.2e-12 45.8 0.0 1.5e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EAK90547.1 - 3.8e-06 26.8 0.0 7.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EAK90547.1 - 4.6e-06 27.0 0.0 1.4e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EAK90547.1 - 0.00012 21.5 0.0 0.00024 20.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EAK90547.1 - 0.00012 21.2 0.0 0.00022 20.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EAK90547.1 - 0.00023 21.5 0.1 0.00057 20.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EAK90547.1 - 0.00048 19.9 0.0 0.00083 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EAK90547.1 - 0.011 15.4 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.14 EAK90547.1 - 0.013 15.5 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_7 PF12775.7 EAK90547.1 - 0.066 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 EAK90547.1 - 0.095 12.8 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 EAK90547.1 - 0.13 12.6 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EAK90547.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Cyclin_N PF00134.23 EAK90548.1 - 0.00045 20.0 0.1 0.00082 19.1 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_N PF00134.23 EAK90549.1 - 1.3e-08 34.7 3.9 3.8e-06 26.7 0.5 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EAK90549.1 - 6.3e-07 29.5 0.6 1.2e-06 28.6 0.2 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Baculo_PEP_C PF04513.12 EAK90550.1 - 0.0018 18.3 4.4 0.73 9.9 0.1 2.6 3 0 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus TssO PF17561.2 EAK90550.1 - 0.0047 17.1 4.8 0.0047 17.1 4.8 3.1 3 1 0 3 3 2 1 Type VI secretion system, TssO HSBP1 PF06825.12 EAK90550.1 - 0.0075 16.1 3.9 0.09 12.6 0.9 3.2 3 1 0 3 3 2 1 Heat shock factor binding protein 1 MCPsignal PF00015.21 EAK90550.1 - 0.012 15.5 3.7 0.64 9.8 0.5 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SNARE PF05739.19 EAK90550.1 - 0.022 14.8 0.1 0.022 14.8 0.1 1.9 2 0 0 2 2 1 0 SNARE domain BLOC1_2 PF10046.9 EAK90550.1 - 0.053 13.8 0.5 0.053 13.8 0.5 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LOH1CR12 PF10158.9 EAK90550.1 - 0.088 12.8 3.7 0.088 12.8 0.7 2.1 2 0 0 2 2 2 0 Tumour suppressor protein GGDEF PF00990.21 EAK90550.1 - 0.12 12.2 2.6 1.4 8.6 0.3 2.4 2 1 0 2 2 2 0 Diguanylate cyclase, GGDEF domain DUF948 PF06103.11 EAK90550.1 - 0.37 11.1 11.9 0.94 9.8 0.4 2.9 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 EAK90550.1 - 0.43 10.6 8.0 2.7 8.0 2.6 2.7 2 1 0 2 2 2 0 Laminin Domain II PBECR1 PF18809.1 EAK90550.1 - 0.58 10.8 0.1 0.58 10.8 0.1 3.3 3 1 1 4 4 4 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 TMF_DNA_bd PF12329.8 EAK90550.1 - 0.73 9.9 13.2 0.16 12.0 3.3 3.4 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 EAK90550.1 - 0.93 9.5 9.6 2.1 8.4 1.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Goodbye PF17109.5 EAK90550.1 - 1.6 9.2 4.6 12 6.4 0.0 3.3 2 2 1 3 3 3 0 fungal STAND N-terminal Goodbye domain UPF0242 PF06785.11 EAK90550.1 - 1.8 8.6 18.7 6.9 6.7 11.3 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 EAK90550.1 - 2.8 8.5 16.0 0.85 10.1 1.1 2.7 3 0 0 3 3 3 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 EAK90550.1 - 3.1 8.0 18.8 1.4 9.1 2.0 3.3 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 EAK90550.1 - 3.6 8.0 8.6 3.4 8.1 2.5 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Nup88 PF10168.9 EAK90550.1 - 3.8 5.2 12.4 0.29 8.9 5.4 1.9 2 0 0 2 2 2 0 Nuclear pore component KxDL PF10241.9 EAK90550.1 - 4.5 7.6 9.0 0.54 10.6 2.2 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein P4Ha_N PF08336.11 EAK90550.1 - 8.9 6.3 11.1 9.5 6.2 0.4 3.4 2 1 1 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF1298 PF06974.13 EAK90551.1 - 4.1e-23 81.9 0.0 7.4e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) PerB PF06590.11 EAK90551.1 - 0.054 14.0 1.0 5.2 7.6 0.3 2.6 2 0 0 2 2 2 0 PerB protein KH_1 PF00013.29 EAK90552.1 - 4.4e-14 52.0 4.8 6.8e-10 38.6 1.7 2.7 3 0 0 3 3 3 2 KH domain Beta_elim_lyase PF01212.21 EAK90552.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase Helicase_C PF00271.31 EAK90553.1 - 0.00015 22.0 4.7 0.1 12.9 0.1 4.1 1 1 2 3 3 3 2 Helicase conserved C-terminal domain Sec20 PF03908.13 EAK90553.1 - 0.95 9.4 6.7 0.97 9.4 0.3 3.4 2 1 0 2 2 2 0 Sec20 BrkDBD PF09607.10 EAK90554.1 - 0.053 13.3 0.1 0.25 11.1 0.1 2.1 1 1 0 1 1 1 0 Brinker DNA-binding domain RRM_1 PF00076.22 EAK90557.1 - 4.2e-35 119.4 1.2 7.4e-17 60.9 0.2 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAK90557.1 - 4.6e-07 29.9 0.1 0.0011 19.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 EAK90557.1 - 6.5e-07 29.0 2.6 0.0053 16.3 0.6 2.7 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EAK90557.1 - 3.4e-05 24.0 0.2 0.26 11.6 0.0 2.6 2 0 0 2 2 2 2 BRCA1-associated protein 2 Methyltransf_23 PF13489.6 EAK90557.1 - 0.56 10.0 5.0 17 5.2 5.9 2.5 2 1 0 2 2 2 0 Methyltransferase domain DUF4413 PF14372.6 EAK90558.1 - 0.16 12.4 2.8 0.4 11.1 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) TGT PF01702.18 EAK90561.1 - 4.3e-142 473.4 0.0 5.5e-142 473.1 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Vac14_Fab1_bd PF12755.7 EAK90563.1 - 0.03 14.9 0.1 0.03 14.9 0.1 4.0 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region DUF4533 PF15047.6 EAK90564.1 - 0.00023 20.8 0.9 0.00038 20.1 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4533) DHR10 PF18595.1 EAK90564.1 - 0.0074 16.3 1.9 0.0074 16.3 1.9 1.8 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain DUF948 PF06103.11 EAK90564.1 - 0.012 15.9 1.5 0.26 11.6 0.9 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) P4Ha_N PF08336.11 EAK90564.1 - 0.015 15.3 1.5 0.45 10.5 0.7 2.5 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Csm1_N PF18504.1 EAK90564.1 - 0.02 15.2 2.1 0.02 15.2 2.1 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF4509 PF14970.6 EAK90564.1 - 0.028 14.4 3.7 0.05 13.5 1.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4509) BCAS2 PF05700.11 EAK90564.1 - 0.037 13.7 3.7 0.26 11.0 2.3 2.1 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Syntaxin-6_N PF09177.11 EAK90564.1 - 0.076 13.6 7.2 0.52 10.9 3.2 2.5 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF4164 PF13747.6 EAK90564.1 - 0.15 12.3 4.7 4.8 7.5 0.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) ABC_tran_CTD PF16326.5 EAK90564.1 - 0.42 10.9 5.7 0.07 13.4 1.2 2.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF1664 PF07889.12 EAK90564.1 - 0.62 10.1 4.9 0.37 10.8 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) E2F_CC-MB PF16421.5 EAK90564.1 - 0.67 10.4 4.8 0.17 12.2 1.3 1.9 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain KELK PF15796.5 EAK90564.1 - 0.67 10.4 7.2 0.078 13.4 1.8 2.3 2 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Prp19 PF08606.11 EAK90564.1 - 0.69 9.9 4.4 0.93 9.5 1.3 2.4 2 0 0 2 2 2 0 Prp19/Pso4-like APG6_N PF17675.1 EAK90564.1 - 2.9 8.4 10.0 9.1 6.8 10.0 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region eIF2A PF08662.11 EAK90565.1 - 2.6e-53 180.8 0.0 3.7e-43 147.7 0.0 3.4 3 0 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A Seipin PF06775.14 EAK90568.1 - 3.2e-27 95.9 13.2 5.3e-26 92.0 13.2 2.4 1 1 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) KASH PF10541.9 EAK90568.1 - 3.2 8.1 5.5 14 6.0 1.4 2.6 2 0 0 2 2 2 0 Nuclear envelope localisation domain SecY PF00344.20 EAK90569.1 - 4e-71 239.8 17.5 4.9e-71 239.5 17.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EAK90569.1 - 1.9e-17 62.8 1.8 3.9e-17 61.8 0.1 2.5 2 0 0 2 2 2 1 Plug domain of Sec61p RRM_1 PF00076.22 EAK90570.1 - 1e-16 60.5 0.0 1.5e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EAK90570.1 - 0.00025 21.0 0.0 0.00078 19.4 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EAK90570.1 - 0.092 12.6 0.0 0.18 11.7 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif CDC45 PF02724.14 EAK90570.1 - 1.4 7.2 3.3 1.5 7.0 3.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DHQ_synthase PF01761.20 EAK90571.1 - 0.41 9.8 1.7 0.68 9.0 0.0 2.0 2 0 0 2 2 2 0 3-dehydroquinate synthase PI_PP_I PF18363.1 EAK90571.1 - 0.87 9.8 8.7 1.8 8.8 0.4 4.1 4 1 0 4 4 4 0 Phosphoinositide phosphatase insertion domain Med3 PF11593.8 EAK90571.1 - 1.5 8.0 8.8 0.064 12.4 2.4 1.9 2 1 0 2 2 2 0 Mediator complex subunit 3 fungal TSC22 PF01166.18 EAK90571.1 - 8.7 6.7 12.4 7.8 6.9 1.1 3.5 3 0 0 3 3 3 0 TSC-22/dip/bun family TPR_12 PF13424.6 EAK90572.1 - 0.011 16.0 0.1 1.2 9.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Suf PF05843.14 EAK90572.1 - 0.024 14.7 23.1 1.3 8.9 0.2 5.0 4 1 1 5 5 5 0 Suppressor of forked protein (Suf) Ank_2 PF12796.7 EAK90573.1 - 8.6e-16 58.3 0.3 1.2e-10 41.8 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAK90573.1 - 1.4e-14 54.2 1.4 1.2e-07 32.1 0.0 5.6 5 1 1 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EAK90573.1 - 4.8e-12 45.7 1.8 0.0038 17.6 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EAK90573.1 - 2.9e-09 36.4 0.7 0.16 12.6 0.0 5.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EAK90573.1 - 4.3e-07 30.1 3.2 0.011 16.0 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeats (many copies) SET PF00856.28 EAK90573.1 - 0.029 14.7 1.6 0.055 13.9 0.1 2.3 2 0 0 2 2 2 0 SET domain Herpes_heli_pri PF05774.11 EAK90573.1 - 0.057 13.6 0.6 19 5.5 0.1 2.7 2 0 0 2 2 2 0 Herpesvirus helicase-primase complex component 2OG-FeII_Oxy_2 PF13532.6 EAK90575.1 - 1e-16 61.8 0.0 3.7e-16 59.9 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3638 PF12340.8 EAK90576.1 - 1e-22 80.6 0.2 2.7e-19 69.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EAK90576.1 - 4e-14 51.7 0.1 7.4e-14 50.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) EF-hand_6 PF13405.6 EAK90576.1 - 2.2e-06 27.1 0.3 0.046 13.7 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EAK90576.1 - 6.1e-05 22.3 3.1 0.023 14.2 0.1 4.2 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EAK90576.1 - 0.0052 17.2 1.0 0.88 10.1 0.1 3.6 3 0 0 3 3 3 1 EF-hand domain pair G10 PF01125.17 EAK90577.1 - 3.5e-59 198.8 8.6 3.8e-59 198.7 8.6 1.0 1 0 0 1 1 1 1 G10 protein DUF2387 PF09526.10 EAK90577.1 - 7.8 6.7 10.7 2.2 8.5 0.4 2.6 2 1 0 3 3 3 0 Probable metal-binding protein (DUF2387) IBN_N PF03810.19 EAK90578.1 - 0.068 13.1 0.2 0.16 11.9 0.2 1.6 1 0 0 1 1 1 0 Importin-beta N-terminal domain RRP7 PF12923.7 EAK90579.1 - 0.0069 16.5 0.8 0.025 14.7 0.0 2.1 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain JAB PF01398.21 EAK90580.1 - 4.5e-14 52.4 0.1 1e-13 51.3 0.0 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EAK90580.1 - 2.8e-06 27.7 0.6 5.8e-06 26.7 0.6 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function PPR_1 PF12854.7 EAK90581.1 - 0.38 10.5 1.2 0.59 9.9 0.0 1.9 2 0 0 2 2 2 0 PPR repeat FPL PF09758.9 EAK90582.1 - 2.6e-50 170.3 10.2 2.6e-50 170.3 10.2 4.0 5 0 0 5 5 5 1 Uncharacterised conserved protein cwf21 PF08312.12 EAK90583.1 - 0.00069 19.7 6.5 0.0023 18.0 6.5 1.9 1 0 0 1 1 1 1 cwf21 domain Bromodomain PF00439.25 EAK90584.1 - 2.8e-22 78.6 1.5 2.8e-22 78.6 1.5 1.8 2 0 0 2 2 2 1 Bromodomain RRN3 PF05327.11 EAK90584.1 - 0.042 12.4 4.9 0.069 11.7 4.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 EAK90584.1 - 0.91 7.7 23.4 2.3 6.4 23.4 1.5 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EAK90584.1 - 2.1 6.6 16.9 3.7 5.7 16.9 1.3 1 0 0 1 1 1 0 CDC45-like protein zf-C3HC4_3 PF13920.6 EAK90585.1 - 0.00038 20.3 6.8 0.00038 20.3 6.8 5.9 5 2 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.18 EAK90585.1 - 0.0017 17.6 4.3 0.0083 15.4 4.3 2.2 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF3877 PF12993.7 EAK90585.1 - 0.022 14.6 1.3 0.46 10.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3877) Helicase_C PF00271.31 EAK90586.1 - 1.9e-12 47.5 3.6 4e-12 46.5 0.2 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EAK90586.1 - 4.4e-11 43.0 0.2 3e-10 40.3 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.29 EAK90586.1 - 1.3e-09 38.1 1.0 2.3e-09 37.2 0.3 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase dsrm PF00035.26 EAK90586.1 - 0.0041 17.8 0.2 0.015 16.0 0.0 2.1 2 0 0 2 2 2 1 Double-stranded RNA binding motif ResIII PF04851.15 EAK90586.1 - 0.0072 16.3 0.3 0.046 13.7 0.3 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EAK90586.1 - 0.014 15.6 0.5 0.8 10.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EAK90586.1 - 0.021 15.4 3.1 0.029 14.9 0.1 2.9 3 0 0 3 3 3 0 ABC transporter OB_NTP_bind PF07717.16 EAK90586.1 - 0.039 14.3 0.1 0.1 12.9 0.1 1.8 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold DND1_DSRM PF14709.7 EAK90586.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 T2SSE PF00437.20 EAK90586.1 - 0.12 11.4 0.0 0.24 10.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Cir_N PF10197.9 EAK90587.1 - 1e-11 44.8 11.8 1e-11 44.8 11.8 2.2 2 1 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR Slu7 PF11708.8 EAK90587.1 - 1.1e-05 25.3 6.2 1.1e-05 25.3 6.2 1.8 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor Pkinase PF00069.25 EAK90588.1 - 5.5e-30 104.6 0.2 1.5e-29 103.2 0.2 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90588.1 - 1.2e-08 34.6 0.0 2.6e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase NAS PF03059.16 EAK90590.1 - 0.015 14.7 2.8 0.02 14.2 2.8 1.1 1 0 0 1 1 1 0 Nicotianamine synthase protein Csm2_III-A PF03750.13 EAK90590.1 - 0.12 13.3 0.7 0.18 12.6 0.7 1.3 1 0 0 1 1 1 0 Csm2 Type III-A DHR10 PF18595.1 EAK90590.1 - 0.14 12.2 6.2 0.085 12.9 3.0 2.0 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain ApoLp-III PF07464.11 EAK90590.1 - 0.15 12.1 1.5 0.87 9.7 1.4 2.0 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) YMF19 PF02326.15 EAK90590.1 - 0.16 12.7 1.0 1.6 9.5 0.1 2.4 2 1 0 2 2 2 0 Plant ATP synthase F0 LEDGF PF11467.8 EAK90590.1 - 1 9.0 6.2 0.67 9.6 3.4 1.9 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) RP-C_C PF11800.8 EAK90590.1 - 1.4 9.0 3.5 4.9 7.2 0.1 2.6 2 1 1 3 3 3 0 Replication protein C C-terminal region Mito_fiss_reg PF05308.11 EAK90590.1 - 2.8 8.0 9.3 5.2 7.1 9.3 1.5 1 1 0 1 1 1 0 Mitochondrial fission regulator Tk-SP_N-pro PF18237.1 EAK90591.1 - 0.039 14.0 0.5 0.25 11.4 0.1 2.5 2 0 0 2 2 2 0 Tk-SP N-propeptide domain Lipoxygenase PF00305.19 EAK90593.1 - 0.033 12.6 0.3 0.045 12.2 0.3 1.1 1 0 0 1 1 1 0 Lipoxygenase YniB PF14002.6 EAK90593.1 - 0.041 13.7 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 YniB-like protein Mucin PF01456.17 EAK90593.1 - 1.8 8.5 15.1 2.8 7.9 15.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Lactococcin PF04369.13 EAK90594.1 - 0.1 12.7 0.2 0.2 11.8 0.2 1.4 1 0 0 1 1 1 0 Lactococcin-like family DUF2500 PF10694.9 EAK90596.1 - 0.1 13.1 0.5 0.23 12.0 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2500) RNA_POL_M_15KD PF02150.16 EAK90597.1 - 1.4e-06 28.0 0.6 3.1e-06 26.9 0.6 1.5 1 0 0 1 1 1 1 RNA polymerases M/15 Kd subunit C1_1 PF00130.22 EAK90597.1 - 0.031 14.1 1.2 0.048 13.5 1.2 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.6 EAK90597.1 - 0.82 10.2 4.8 2.3 8.8 5.0 1.6 1 1 0 1 1 1 0 Zinc-finger double domain Glycos_transf_2 PF00535.26 EAK90598.1 - 5.6e-19 68.6 0.0 1.2e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EAK90598.1 - 1.2e-06 28.8 0.3 0.00017 21.8 0.1 3.4 3 1 1 4 4 4 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EAK90598.1 - 1.6e-06 28.2 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EAK90598.1 - 0.00026 20.6 0.4 0.00069 19.2 0.4 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 EAK90598.1 - 0.0039 16.7 0.0 0.0069 15.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 MliC PF09864.9 EAK90598.1 - 0.19 11.7 0.1 0.47 10.4 0.1 1.6 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Ribosomal_S27e PF01667.17 EAK90599.1 - 8.4e-26 89.4 6.2 1.1e-25 89.1 6.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 Prok-RING_1 PF14446.6 EAK90599.1 - 0.21 11.5 3.9 0.34 10.9 3.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DHHC PF01529.20 EAK90600.1 - 3.6e-34 117.7 14.0 3.6e-34 117.7 14.0 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase zf-ribbon_3 PF13248.6 EAK90600.1 - 0.45 10.0 8.0 0.79 9.2 3.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF2985 PF11204.8 EAK90600.1 - 1.1 9.5 6.3 0.15 12.2 0.7 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2985) DUF5366 PF17328.2 EAK90600.1 - 3.3 7.8 18.1 0.41 10.8 3.4 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5366) RRM_1 PF00076.22 EAK90601.1 - 2.7e-17 62.4 0.1 4.5e-17 61.6 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAK90601.1 - 0.0013 18.4 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EAK90601.1 - 0.0049 17.1 0.2 0.011 16.0 0.0 1.7 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EAK90601.1 - 0.0096 16.0 0.2 0.021 14.9 0.2 1.9 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EAK90601.1 - 0.032 14.2 0.0 0.065 13.2 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF3882 PF07066.11 EAK90601.1 - 0.038 14.1 0.4 0.1 12.7 0.0 1.8 1 1 0 2 2 2 0 Lactococcus phage M3 protein Methyltr_RsmB-F PF01189.17 EAK90602.1 - 3.5e-40 137.8 0.0 1.6e-39 135.6 0.0 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EAK90602.1 - 0.009 16.1 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase SRP54 PF00448.22 EAK90603.1 - 5e-75 251.5 0.1 1.7e-74 249.8 0.0 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EAK90603.1 - 9.3e-32 109.6 3.6 9.3e-32 109.6 3.6 2.6 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 EAK90603.1 - 2.3e-19 69.4 1.4 6.3e-19 68.0 1.4 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 EAK90603.1 - 5.2e-05 23.4 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EAK90603.1 - 0.0001 22.0 0.3 0.00064 19.3 0.1 2.3 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 EAK90603.1 - 0.00024 21.2 0.0 0.0022 18.0 0.0 2.7 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EAK90603.1 - 0.00028 19.9 0.4 0.0061 15.6 0.0 2.9 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EAK90603.1 - 0.00037 20.9 0.0 0.0017 18.8 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EAK90603.1 - 0.00051 19.4 0.0 0.00096 18.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin ResIII PF04851.15 EAK90603.1 - 0.0016 18.5 0.0 0.004 17.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EAK90603.1 - 0.003 17.8 0.0 0.014 15.7 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EAK90603.1 - 0.004 16.9 0.0 0.0096 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EAK90603.1 - 0.0052 17.2 1.4 0.018 15.5 0.1 2.5 2 2 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EAK90603.1 - 0.007 16.3 0.2 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase ATP_bind_1 PF03029.17 EAK90603.1 - 0.0082 16.0 0.1 0.039 13.7 0.1 2.2 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 EAK90603.1 - 0.01 15.1 0.0 0.02 14.2 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.6 EAK90603.1 - 0.016 15.4 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EAK90603.1 - 0.019 14.8 0.1 0.37 10.6 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NTPase_1 PF03266.15 EAK90603.1 - 0.023 14.6 0.7 1.4 8.8 0.7 2.7 1 1 0 1 1 1 0 NTPase MobB PF03205.14 EAK90603.1 - 0.027 14.4 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Fe-ADH PF00465.19 EAK90603.1 - 0.04 12.7 0.0 0.077 11.8 0.0 1.4 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Thymidylate_kin PF02223.17 EAK90603.1 - 0.053 13.2 0.0 0.19 11.4 0.0 2.0 1 0 0 1 1 1 0 Thymidylate kinase DUF2209 PF09974.9 EAK90603.1 - 0.059 13.7 1.3 0.19 12.1 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2209) AAA_31 PF13614.6 EAK90603.1 - 0.063 13.2 0.1 0.79 9.6 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EAK90603.1 - 0.083 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EAK90603.1 - 0.092 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EAK90603.1 - 0.11 12.6 0.3 0.76 9.9 0.1 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA PF00004.29 EAK90603.1 - 0.11 12.9 1.3 1.7 9.1 0.0 3.5 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EAK90603.1 - 0.13 12.8 0.1 0.54 10.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EAK90603.1 - 0.2 11.1 2.6 3 7.3 0.6 2.6 2 1 0 2 2 1 0 Signal recognition particle receptor beta subunit ArsA_ATPase PF02374.15 EAK90603.1 - 7.1 5.7 7.4 1.9 7.6 0.0 3.5 3 2 1 4 4 4 0 Anion-transporting ATPase Clr5 PF14420.6 EAK90604.1 - 0.00064 19.9 2.7 1.2 9.4 0.0 3.5 4 0 0 4 4 4 2 Clr5 domain STOP PF05217.12 EAK90604.1 - 0.0061 16.8 0.1 0.0061 16.8 0.1 4.6 6 0 0 6 6 6 1 STOP protein IBN_N PF03810.19 EAK90605.1 - 2.2e-06 27.5 0.1 8.1e-06 25.7 0.1 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain PhoLip_ATPase_C PF16212.5 EAK90606.1 - 2.5e-54 184.7 30.7 2.5e-54 184.7 30.7 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EAK90606.1 - 1.8e-20 72.4 5.0 1.8e-20 72.4 5.0 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EAK90606.1 - 4.2e-13 50.1 0.1 7.2e-08 33.0 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EAK90606.1 - 3.7e-08 33.1 0.0 3.7e-08 33.1 0.0 3.5 4 1 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EAK90606.1 - 0.00012 22.0 0.0 0.00055 20.0 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EAK90606.1 - 0.007 16.1 1.7 0.065 13.0 0.0 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Ferredoxin_N PF16947.5 EAK90606.1 - 0.068 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 N-terminal region of 4Fe-4S ferredoxin iron-sulfur binding SMC_N PF02463.19 EAK90607.1 - 3.4e-60 203.2 53.1 1.5e-59 201.1 53.1 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EAK90607.1 - 3.4e-20 72.5 0.9 1.4e-19 70.5 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EAK90607.1 - 4.8e-15 56.6 6.1 4.8e-15 56.6 6.1 7.6 2 2 3 5 5 5 1 AAA domain AAA_21 PF13304.6 EAK90607.1 - 6.4e-15 55.7 25.1 6.7e-08 32.7 9.6 4.4 3 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EAK90607.1 - 4.7e-10 39.7 12.3 4.7e-10 39.7 12.3 4.6 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 EAK90607.1 - 3.4e-07 29.9 0.0 6.3e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EAK90607.1 - 0.035 14.6 0.0 0.035 14.6 0.0 6.6 3 2 0 3 3 3 0 ABC transporter CREPT PF16566.5 EAK90607.1 - 0.04 14.1 0.4 0.04 14.1 0.4 8.5 4 2 5 9 9 9 0 Cell-cycle alteration and expression-elevated protein in tumour Tropomyosin_1 PF12718.7 EAK90607.1 - 6.5 6.9 135.3 0.72 10.0 13.2 8.1 3 3 2 6 6 6 0 Tropomyosin like AAA_22 PF13401.6 EAK90607.1 - 7.8 6.8 8.1 0.93 9.8 0.0 3.7 4 1 0 4 4 4 0 AAA domain Ribosomal_L44 PF00935.19 EAK90608.1 - 9.4e-34 115.7 15.2 1.2e-33 115.4 15.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L44 Ribosomal_L33 PF00471.20 EAK90608.1 - 1.1 9.7 10.7 1.2 9.7 0.9 2.9 2 1 1 3 3 3 0 Ribosomal protein L33 Adaptin_N PF01602.20 EAK90609.1 - 4e-77 259.9 15.3 5.5e-77 259.5 15.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EAK90609.1 - 5.9e-28 97.9 0.1 5e-27 94.9 0.0 2.2 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EAK90609.1 - 1.8e-24 86.0 0.0 5.3e-24 84.6 0.0 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EAK90609.1 - 1.9e-07 31.4 0.4 9.3e-05 22.7 0.0 3.8 3 0 0 3 3 3 1 HEAT repeats Cnd1 PF12717.7 EAK90609.1 - 1.9e-06 28.0 12.9 5.2e-05 23.3 0.0 4.6 1 1 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EAK90609.1 - 3.6 8.1 10.8 9 6.9 0.3 5.6 6 0 0 6 6 6 0 HEAT repeat Sld5 PF05916.11 EAK90610.1 - 3.7e-15 56.3 0.0 5e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein Glyco_hydro_15 PF00723.21 EAK90610.1 - 0.033 13.0 0.0 0.033 13.0 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 15 FAP206 PF12018.8 EAK90610.1 - 0.054 13.0 0.2 0.062 12.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function NPL4 PF05021.15 EAK90611.1 - 3.5e-31 108.7 0.0 1.3e-29 103.5 0.0 2.5 1 1 0 1 1 1 1 NPL4 family UN_NPL4 PF11543.8 EAK90611.1 - 1.6e-21 76.5 0.6 4.6e-21 75.1 0.1 2.0 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 zf-NPL4 PF05020.15 EAK90611.1 - 2e-06 28.0 0.0 3.8e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region ACP_syn_III_C PF08541.10 EAK90611.1 - 0.0045 17.1 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ubiquitin PF00240.23 EAK90611.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Tubulin PF00091.25 EAK90612.1 - 2.2e-69 233.6 0.0 5.1e-69 232.4 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EAK90612.1 - 4.1e-43 146.5 1.0 4.1e-43 146.5 1.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EAK90612.1 - 0.00023 21.5 0.0 0.00091 19.5 0.0 2.1 2 1 0 2 2 2 1 Misato Segment II tubulin-like domain Hrs_helical PF12210.8 EAK90612.1 - 0.0018 18.7 0.1 0.0043 17.6 0.1 1.6 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate Tubulin_2 PF13809.6 EAK90612.1 - 0.0028 16.9 0.0 0.005 16.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin like SIR2 PF02146.17 EAK90613.1 - 3.2e-22 79.3 0.0 4.3e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF1936 PF09151.10 EAK90613.1 - 0.033 14.1 0.1 0.033 14.1 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1936) TPP_enzyme_M PF00205.22 EAK90613.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Mistic PF11458.8 EAK90613.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 Membrane-integrating protein Mistic IL8 PF00048.20 EAK90613.1 - 0.36 11.0 4.0 13 6.0 0.2 2.4 2 0 0 2 2 2 0 Small cytokines (intecrine/chemokine), interleukin-8 like LSM PF01423.22 EAK90614.1 - 2.9e-16 58.9 0.1 3.6e-16 58.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EAK90614.1 - 8.5e-05 22.6 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EAK90614.1 - 0.042 13.9 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Scd6-like Sm domain Aha1_N PF09229.11 EAK90615.1 - 5.5e-32 110.8 11.3 1.3e-22 80.5 2.2 2.5 2 1 1 3 3 3 2 Activator of Hsp90 ATPase, N-terminal LMBR1 PF04791.16 EAK90615.1 - 1.2 7.9 5.8 1.4 7.8 5.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PRP21_like_P PF12230.8 EAK90616.1 - 9.1e-60 202.2 9.9 1.4e-59 201.6 9.9 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EAK90616.1 - 6.8e-35 118.8 0.5 9.1e-17 60.8 0.0 2.5 2 0 0 2 2 2 2 Surp module FinO_N PF12602.8 EAK90616.1 - 0.039 14.3 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Fertility inhibition protein N terminal IL5 PF02025.15 EAK90616.1 - 0.089 13.1 0.8 0.17 12.1 0.8 1.4 1 0 0 1 1 1 0 Interleukin 5 DUF2353 PF09789.9 EAK90617.1 - 0.00014 21.4 5.8 0.00014 21.4 5.8 4.1 4 1 0 4 4 4 2 Uncharacterized coiled-coil protein (DUF2353) ApoO PF09769.9 EAK90617.1 - 0.93 9.5 3.2 0.89 9.5 0.3 2.4 2 0 0 2 2 2 0 Apolipoprotein O ubiquitin PF00240.23 EAK90618.1 - 5.8e-35 118.9 0.3 7.5e-35 118.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EAK90618.1 - 2.5e-29 100.9 9.6 3.9e-29 100.3 9.6 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EAK90618.1 - 5e-17 61.5 0.4 8.1e-17 60.8 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EAK90618.1 - 4.5e-06 27.0 0.1 1.7e-05 25.2 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EAK90618.1 - 0.0032 17.4 0.1 0.0045 16.9 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EAK90618.1 - 0.0032 17.5 0.1 0.0066 16.5 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EAK90618.1 - 0.0063 16.9 0.1 0.0093 16.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EAK90618.1 - 0.024 14.7 0.7 7 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EAK90618.1 - 0.049 14.2 0.0 0.057 14.0 0.0 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain eIF-5a PF01287.20 EAK90619.1 - 4.5e-23 81.1 0.0 7e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EAK90619.1 - 0.0066 16.5 0.1 0.0096 15.9 0.1 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Arf PF00025.21 EAK90620.1 - 1.6e-62 210.0 0.0 1.9e-62 209.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EAK90620.1 - 4.3e-13 49.2 0.5 8.2e-10 38.4 0.1 2.5 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EAK90620.1 - 5.3e-11 42.3 0.0 7e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EAK90620.1 - 2.8e-09 36.8 0.0 3.5e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAK90620.1 - 5.4e-09 36.3 0.0 1.4e-08 35.0 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EAK90620.1 - 1.4e-07 31.6 0.0 1.9e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EAK90620.1 - 7.5e-06 25.5 0.0 9.5e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EAK90620.1 - 0.0027 17.3 0.0 0.046 13.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EAK90620.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NOG1 PF06858.14 EAK90620.1 - 0.14 12.0 0.1 0.58 10.0 0.1 2.1 2 1 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) RNase_PH PF01138.21 EAK90621.1 - 6.2e-13 49.4 0.2 3.2e-12 47.1 0.0 2.2 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EAK90621.1 - 5.3e-10 39.2 0.0 1.2e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF2977 PF11192.8 EAK90621.1 - 0.038 14.1 0.7 0.074 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2977) Cpn10 PF00166.21 EAK90622.1 - 4.4e-15 55.5 0.0 6.3e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit PS_pyruv_trans PF04230.13 EAK90623.1 - 2e-14 54.2 7.8 1.8e-13 51.1 7.8 2.5 1 1 0 1 1 1 1 Polysaccharide pyruvyl transferase SMC_N PF02463.19 EAK90624.1 - 3.7e-50 170.4 22.0 1.1e-49 168.8 22.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EAK90624.1 - 4.2e-36 123.8 0.5 1.3e-35 122.2 0.5 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EAK90624.1 - 1.8e-17 64.6 6.0 1.8e-17 64.6 6.0 7.4 3 2 3 6 6 6 1 AAA domain AAA_15 PF13175.6 EAK90624.1 - 1.7e-13 51.1 13.0 1.7e-13 51.1 13.0 4.9 1 1 3 4 4 4 2 AAA ATPase domain AAA_21 PF13304.6 EAK90624.1 - 5.2e-10 39.6 34.2 7.3e-06 26.0 0.3 5.3 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EAK90624.1 - 0.00014 21.5 0.0 0.0003 20.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EAK90624.1 - 0.0067 16.9 0.0 0.0067 16.9 0.0 5.5 3 2 0 4 4 4 1 ABC transporter SRA1 PF07304.11 EAK90624.1 - 0.03 14.1 0.3 0.13 12.0 0.3 2.1 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) SbcCD_C PF13558.6 EAK90624.1 - 0.09 13.0 0.0 0.3 11.3 0.0 1.9 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SLBP_RNA_bind PF15247.6 EAK90626.1 - 7.1e-23 80.5 1.5 1.3e-22 79.7 1.5 1.4 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain CTP_transf_like PF01467.26 EAK90627.1 - 1.9e-30 106.0 0.0 9.4e-15 55.1 0.0 2.4 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EAK90627.1 - 0.0014 18.6 0.3 2.2 8.2 0.1 3.0 3 0 0 3 3 3 2 FAD synthetase DUF726 PF05277.12 EAK90627.1 - 0.01 14.8 0.0 0.2 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF726) TPP_enzyme_N PF02776.18 EAK90628.1 - 1.2e-29 103.1 0.0 2.3e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EAK90628.1 - 9.5e-23 80.5 0.0 2.2e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EAK90628.1 - 3.9e-16 59.2 0.0 1.7e-15 57.1 0.0 2.1 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 EAK90628.1 - 0.0086 15.9 0.2 0.018 14.8 0.2 1.5 1 0 0 1 1 1 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Thioredoxin PF00085.20 EAK90629.1 - 7.3e-09 35.6 0.1 1.7e-08 34.4 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EAK90629.1 - 1.8e-08 33.7 2.0 2e-08 33.5 2.0 1.1 1 0 0 1 1 1 1 Phosducin Soyouz_module PF14313.6 EAK90629.1 - 0.49 10.2 2.4 1.5 8.6 0.8 2.5 3 0 0 3 3 3 0 N-terminal region of Paramyxovirinae phosphoprotein (P) Skp1 PF01466.19 EAK90629.1 - 1.5 9.0 7.3 8.3 6.6 0.6 2.6 1 1 1 2 2 2 0 Skp1 family, dimerisation domain Cpn60_TCP1 PF00118.24 EAK90630.1 - 3.8e-149 497.5 7.4 4.3e-149 497.3 7.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DHHC PF01529.20 EAK90631.1 - 5.2e-34 117.2 14.0 5.2e-34 117.2 14.0 2.7 2 1 1 3 3 3 1 DHHC palmitoyltransferase Urm1 PF09138.11 EAK90632.1 - 1.7e-30 105.2 0.3 1.9e-30 105.1 0.3 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EAK90632.1 - 0.0095 16.6 0.1 0.03 15.0 0.1 1.9 1 1 0 1 1 1 1 ThiS family Topoisom_I PF01028.20 EAK90633.1 - 1.2e-103 345.4 7.9 1.2e-103 345.4 7.9 2.1 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EAK90633.1 - 5.8e-83 277.6 6.1 5.8e-83 277.6 6.1 3.0 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EAK90633.1 - 4.3e-31 106.6 1.1 1.4e-30 105.0 1.1 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain Stk19 PF10494.9 EAK90633.1 - 0.019 14.6 0.4 0.045 13.4 0.4 1.5 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 DUF1853 PF08907.11 EAK90633.1 - 0.087 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1853) LSM PF01423.22 EAK90634.1 - 3.4e-12 45.9 0.2 4.4e-12 45.5 0.2 1.1 1 0 0 1 1 1 1 LSM domain Gemin6 PF06372.12 EAK90634.1 - 0.14 11.7 0.0 0.14 11.6 0.0 1.0 1 0 0 1 1 1 0 Gemin6 protein Gon7 PF08738.10 EAK90635.1 - 0.023 14.8 0.5 0.087 12.9 0.5 1.9 1 0 0 1 1 1 0 Gon7 family KLRAQ PF10205.9 EAK90635.1 - 0.031 14.5 9.1 0.048 13.9 3.0 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DivIC PF04977.15 EAK90635.1 - 0.46 10.3 13.8 0.044 13.5 3.4 2.5 2 0 0 2 2 2 0 Septum formation initiator betaPIX_CC PF16523.5 EAK90635.1 - 2.7 7.9 7.2 6.3 6.7 1.4 2.5 2 0 0 2 2 2 0 betaPIX coiled coil NRBF2 PF08961.10 EAK90635.1 - 3 7.4 10.6 1.8 8.1 1.3 2.5 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator FlxA PF14282.6 EAK90635.1 - 4.9 7.2 11.7 5.6 7.0 2.6 2.8 2 1 0 2 2 2 0 FlxA-like protein YabA PF06156.13 EAK90635.1 - 7.2 7.3 9.4 5.8 7.6 0.2 2.5 2 1 0 2 2 2 0 Initiation control protein YabA Kelch_4 PF13418.6 EAK90636.1 - 2.5e-37 126.6 11.2 5.9e-07 29.4 0.0 6.7 6 2 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EAK90636.1 - 1.5e-31 108.1 4.9 5.8e-07 29.6 0.1 7.6 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EAK90636.1 - 4.8e-25 87.1 8.9 3.5e-06 26.9 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EAK90636.1 - 4.3e-24 83.9 15.1 1.7e-06 28.1 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EAK90636.1 - 1.5e-18 66.1 18.2 6e-06 25.7 0.2 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EAK90636.1 - 7.6e-14 51.0 16.4 3.8e-05 23.5 0.5 6.6 6 0 0 6 6 6 5 Kelch motif DUF4110 PF13422.6 EAK90636.1 - 1.9e-13 50.3 0.3 1.9e-13 50.3 0.3 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) Proteasome PF00227.26 EAK90637.1 - 7.6e-59 198.4 0.0 3.5e-58 196.2 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EAK90637.1 - 1.2e-10 40.8 1.0 3.2e-10 39.5 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DEAD PF00270.29 EAK90638.1 - 3.5e-42 144.1 0.0 6.7e-42 143.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAK90638.1 - 1.4e-30 105.8 0.0 6.8e-30 103.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAK90638.1 - 5.7e-05 23.2 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EAK90638.1 - 0.001 18.5 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 EAK90638.1 - 0.0021 17.8 0.0 0.0046 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EAK90638.1 - 0.0068 16.7 0.1 0.03 14.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EAK90638.1 - 0.0094 16.3 0.0 0.022 15.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain ATP-synt_ab PF00006.25 EAK90638.1 - 0.067 12.8 0.0 0.087 12.5 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Spore_GerQ PF09671.10 EAK90638.1 - 0.087 12.8 0.3 3.6 7.7 0.3 2.6 2 0 0 2 2 2 0 Spore coat protein (Spore_GerQ) Helicase_RecD PF05127.14 EAK90638.1 - 0.16 11.8 0.0 0.43 10.4 0.0 1.6 2 0 0 2 2 2 0 Helicase Ribosomal_L38e PF01781.18 EAK90639.1 - 9e-29 99.4 3.4 1e-28 99.2 3.4 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Thioredoxin PF00085.20 EAK90640.1 - 3.2e-52 174.8 0.1 4.3e-28 97.3 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EAK90640.1 - 5.8e-09 36.1 1.2 5.5e-05 23.1 0.1 2.8 3 0 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EAK90640.1 - 5.9e-07 29.1 0.2 9.2e-05 21.9 0.1 2.7 3 0 0 3 3 3 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EAK90640.1 - 9.3e-07 29.3 2.2 0.1 13.0 0.1 4.4 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EAK90640.1 - 1e-06 28.9 0.1 0.008 16.5 0.0 3.9 2 2 2 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EAK90640.1 - 3e-06 27.3 0.0 0.014 15.5 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EAK90640.1 - 1.7e-05 24.8 0.1 0.0074 16.2 0.0 2.5 2 0 0 2 2 2 2 AhpC/TSA family TraF PF13728.6 EAK90640.1 - 0.00093 19.1 0.0 0.44 10.3 0.0 2.6 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EAK90640.1 - 0.0017 18.4 0.0 0.063 13.3 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EAK90640.1 - 0.0049 17.0 0.8 0.071 13.3 0.3 2.7 1 1 1 2 2 2 1 Thioredoxin Redoxin PF08534.10 EAK90640.1 - 0.023 14.4 0.1 0.5 10.1 0.0 2.6 3 0 0 3 3 3 0 Redoxin DSBA PF01323.20 EAK90640.1 - 0.039 13.7 0.4 2.1 8.1 0.0 3.1 2 2 1 3 3 3 0 DSBA-like thioredoxin domain HyaE PF07449.11 EAK90640.1 - 0.11 12.5 0.0 2 8.4 0.0 2.6 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Methyltr_RsmB-F PF01189.17 EAK90641.1 - 2.7e-21 76.1 0.0 2.5e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F UPF0449 PF15136.6 EAK90641.1 - 0.0071 16.8 0.4 0.015 15.7 0.4 1.6 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 CSN7a_helixI PF18392.1 EAK90641.1 - 0.063 13.2 0.4 0.17 11.8 0.4 1.7 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain FtsJ PF01728.19 EAK90641.1 - 0.067 13.3 0.0 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase DUF4965 PF16335.5 EAK90641.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4965) Methyltransf_31 PF13847.6 EAK90641.1 - 0.088 12.6 0.2 9.8 6.0 0.1 3.0 3 0 0 3 3 3 0 Methyltransferase domain Castor1_N PF18700.1 EAK90641.1 - 0.089 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain Band_7 PF01145.25 EAK90642.1 - 5.9e-23 81.8 0.4 1.2e-22 80.7 0.4 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EAK90642.1 - 3.7e-07 29.5 0.6 5.3e-07 29.0 0.6 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial CS PF04969.16 EAK90643.1 - 2.6e-15 57.2 2.0 5.4e-15 56.2 2.0 1.6 1 0 0 1 1 1 1 CS domain Nudc_N PF14050.6 EAK90643.1 - 1.4e-14 53.8 0.5 3.4e-14 52.5 0.5 1.7 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. DUF1682 PF07946.14 EAK90643.1 - 0.075 12.2 6.7 0.13 11.4 6.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MscS_TM PF12794.7 EAK90643.1 - 6.9 5.4 5.5 9.7 4.9 5.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ISP3_C PF18045.1 EAK90644.1 - 3.3e-25 88.1 0.6 4.5e-25 87.6 0.6 1.2 1 0 0 1 1 1 1 ISP3 C-terminal ISP1_C PF18161.1 EAK90644.1 - 2.3e-22 79.0 0.7 3.2e-22 78.6 0.7 1.2 1 0 0 1 1 1 1 ISP1 C-terminal DUF3751 PF12571.8 EAK90644.1 - 0.15 12.1 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Phage tail-collar fibre protein LSM PF01423.22 EAK90645.1 - 8.5e-18 63.8 0.5 1.2e-17 63.3 0.5 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EAK90645.1 - 0.00016 21.8 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EAK90645.1 - 0.0062 16.6 0.0 0.0091 16.1 0.0 1.3 1 1 0 1 1 1 1 Scd6-like Sm domain Rep_fac-A_C PF08646.10 EAK90646.1 - 5.7e-27 94.3 0.8 1.7e-26 92.7 0.1 2.0 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EAK90646.1 - 5.9e-24 83.8 0.3 1.9e-21 75.8 0.0 2.5 2 0 0 2 2 2 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 EAK90646.1 - 5.6e-14 51.9 0.4 1.3e-10 41.2 0.2 3.8 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 EAK90646.1 - 1.7e-07 31.4 0.2 5.1e-06 26.7 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function DUF223 CDC24_OB3 PF17244.2 EAK90646.1 - 0.0024 17.6 0.4 0.044 13.5 0.1 3.0 3 1 0 3 3 3 1 Cell division control protein 24, OB domain 3 UPF0052 PF01933.18 EAK90646.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0052 DZR PF12773.7 EAK90646.1 - 0.12 12.4 0.6 0.28 11.2 0.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon Sgf11 PF08209.11 EAK90646.1 - 0.2 11.2 2.7 3.2 7.4 0.2 2.6 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf_C2H2_10 PF18414.1 EAK90646.1 - 9.8 5.8 6.3 9.4 5.9 0.3 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger PP2C PF00481.21 EAK90647.1 - 8e-13 48.6 0.4 1.1e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EAK90647.1 - 3.7e-12 46.6 0.0 1.4e-11 44.7 0.0 1.8 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EAK90647.1 - 4e-07 29.9 0.0 5.6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DUF1647 PF07801.11 EAK90647.1 - 0.0086 15.8 0.6 0.02 14.7 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) DUF483 PF04467.12 EAK90647.1 - 0.033 14.2 0.4 0.084 12.9 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF483) UBA PF00627.31 EAK90648.1 - 5.1e-28 96.6 4.4 8e-14 51.2 0.2 2.6 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 EAK90648.1 - 6.8e-22 77.0 5.9 1.6e-21 75.8 5.9 1.7 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EAK90648.1 - 1.8e-16 59.7 0.4 1.8e-16 59.7 0.4 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EAK90648.1 - 4.3e-09 36.1 0.8 7.6e-09 35.3 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EAK90648.1 - 3.1e-07 30.9 1.5 7.8e-07 29.6 1.5 1.8 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EAK90648.1 - 7.5e-07 29.2 1.4 1.6e-06 28.2 1.4 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EAK90648.1 - 2.1e-05 24.3 0.0 0.099 12.5 0.0 2.9 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain Ubiquitin_5 PF18037.1 EAK90648.1 - 0.0036 17.6 3.7 0.0088 16.4 3.7 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain YukD PF08817.10 EAK90648.1 - 0.012 16.3 0.0 0.038 14.7 0.0 1.9 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD UPF0147 PF03685.13 EAK90648.1 - 0.041 13.9 0.7 0.14 12.2 0.7 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) Ubiquitin_4 PF18036.1 EAK90648.1 - 1.9 8.6 6.9 3.6 7.7 0.9 3.0 2 1 1 3 3 3 0 Ubiquitin-like domain DUF3306 PF11748.8 EAK90648.1 - 5.7 7.8 7.6 0.18 12.7 0.9 1.9 3 0 0 3 3 2 0 Protein of unknown function (DUF3306) Aa_trans PF01490.18 EAK90649.1 - 3.8e-50 170.8 29.7 1.8e-49 168.6 29.7 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1761 PF08570.10 EAK90649.1 - 0.44 10.8 0.1 0.44 10.8 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1761) NCOA_u2 PF16665.5 EAK90649.1 - 0.67 10.3 5.9 1.3 9.3 5.9 1.4 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein Coatomer_WDAD PF04053.14 EAK90650.1 - 1e-126 423.6 2.1 1.7e-126 422.9 0.1 2.1 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EAK90650.1 - 8.6e-37 124.5 9.7 1.4e-08 35.2 0.0 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAK90650.1 - 3.1e-09 37.0 1.6 1.8 8.9 0.0 6.4 3 2 5 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EAK90650.1 - 0.0019 16.9 1.7 0.075 11.7 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 TPR_1 PF00515.28 EAK90650.1 - 0.0041 16.9 0.0 0.023 14.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAK90650.1 - 0.013 15.6 0.2 0.15 12.4 0.0 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EAK90650.1 - 0.021 14.9 0.1 0.13 12.5 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.20 EAK90650.1 - 0.065 13.1 0.2 1.1 9.2 0.0 2.5 1 1 1 2 2 2 0 Region in Clathrin and VPS Macoilin PF09726.9 EAK90650.1 - 8.7 4.8 14.5 12 4.3 14.5 1.2 1 0 0 1 1 1 0 Macoilin family ATP-synt_ab PF00006.25 EAK90651.1 - 1.5e-104 348.3 0.0 2.1e-104 347.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EAK90651.1 - 2.1e-41 140.6 0.0 4.8e-41 139.4 0.0 1.7 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EAK90651.1 - 1e-14 54.8 0.8 2.3e-14 53.7 0.8 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Ribosomal_S10 PF00338.22 EAK90652.1 - 3.7e-28 97.6 0.8 4e-28 97.5 0.2 1.3 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e PriA_C PF18074.1 EAK90652.1 - 0.032 15.1 0.1 0.069 14.0 0.0 1.6 2 0 0 2 2 2 0 Primosomal protein N C-terminal domain RAG1_imp_bd PF12560.8 EAK90652.1 - 0.055 13.0 0.1 0.055 13.0 0.1 1.1 1 0 0 1 1 1 0 RAG1 importin binding FeS_assembly_P PF01883.19 EAK90653.1 - 0.00018 21.6 0.0 0.00037 20.6 0.0 1.5 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein SET PF00856.28 EAK90654.1 - 6.9e-19 68.8 0.2 1.3e-18 68.0 0.2 1.5 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 EAK90654.1 - 0.0034 17.4 13.7 0.0034 17.4 13.7 3.5 3 1 0 3 3 3 1 MYND finger DUF1073 PF06381.11 EAK90654.1 - 0.016 14.1 0.3 0.031 13.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1073) Minor_capsid_3 PF12691.7 EAK90654.1 - 0.53 10.7 5.1 0.22 11.9 0.8 2.4 2 1 0 2 2 2 0 Minor capsid protein from bacteriophage Lge1 PF11488.8 EAK90654.1 - 1.7 8.9 8.6 3.1 8.1 4.7 2.7 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 RRM_1 PF00076.22 EAK90655.1 - 1.3e-07 31.3 0.1 3e-07 30.2 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAK90655.1 - 0.0015 18.2 0.0 0.0019 17.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAK90655.1 - 0.023 14.6 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Tyr_Deacylase PF02580.16 EAK90656.1 - 5.9e-48 163.1 0.0 6.7e-48 162.9 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Methyltransf_16 PF10294.9 EAK90657.1 - 6.5e-22 78.1 0.0 1.4e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Ank_4 PF13637.6 EAK90657.1 - 3e-15 56.4 1.3 3.2e-07 30.8 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EAK90657.1 - 1.2e-14 54.2 1.4 7e-11 42.2 0.5 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EAK90657.1 - 3.7e-12 46.1 0.4 3e-05 24.3 0.5 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EAK90657.1 - 7.8e-12 45.6 1.2 2.3e-07 31.3 0.3 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EAK90657.1 - 1.4e-11 43.5 0.1 0.00094 19.5 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat MTS PF05175.14 EAK90657.1 - 0.015 14.9 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 EAK90657.1 - 0.028 14.3 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EAK90657.1 - 0.038 13.8 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EAK90657.1 - 0.056 14.2 0.1 0.24 12.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain PrmA PF06325.13 EAK90657.1 - 0.058 12.8 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EAK90657.1 - 0.071 13.8 0.0 0.35 11.6 0.0 2.3 3 1 0 3 3 1 0 Methyltransferase domain EIF_2_alpha PF07541.12 EAK90658.1 - 8.3e-29 100.0 0.3 1.5e-27 96.0 0.0 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EAK90658.1 - 1.8e-13 50.6 0.6 4e-13 49.5 0.6 1.6 1 0 0 1 1 1 1 S1 RNA binding domain Ribosomal_L24e PF01246.20 EAK90659.1 - 2.2e-31 107.9 7.7 2.2e-31 107.9 7.7 2.0 3 0 0 3 3 3 1 Ribosomal protein L24e zf-FCS PF06467.14 EAK90659.1 - 0.0078 16.1 2.5 0.019 14.9 2.3 1.9 1 1 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif FDF PF09532.10 EAK90659.1 - 0.13 13.1 2.6 0.29 12.1 2.6 1.5 1 0 0 1 1 1 0 FDF domain LSM PF01423.22 EAK90660.1 - 1.3e-15 56.8 2.2 1.7e-15 56.5 2.2 1.1 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.7 EAK90660.1 - 0.0033 17.5 0.9 0.0043 17.1 0.9 1.4 1 1 0 1 1 1 1 Scd6-like Sm domain Peptidase_M23 PF01551.22 EAK90660.1 - 0.069 13.4 0.0 0.13 12.5 0.0 1.5 1 1 1 2 2 2 0 Peptidase family M23 Prp18 PF02840.15 EAK90661.1 - 3.7e-54 182.7 0.4 3.7e-54 182.7 0.4 1.8 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EAK90661.1 - 2.2e-13 49.5 3.3 4.7e-13 48.4 3.3 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Pkinase PF00069.25 EAK90662.1 - 1.1e-66 224.9 0.3 1.6e-43 149.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90662.1 - 1.8e-34 119.2 0.0 2.7e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 EAK90662.1 - 3.3e-14 53.1 0.2 6e-08 33.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAK90662.1 - 4.3e-09 35.3 0.7 0.018 14.6 0.1 3.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EAK90662.1 - 5.8e-08 32.0 0.6 0.013 15.4 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EAK90662.1 - 7.1e-08 32.2 0.7 0.0014 18.4 0.0 3.6 1 1 2 3 3 3 2 EF-hand domain pair Kdo PF06293.14 EAK90662.1 - 2.5e-06 27.0 0.2 7.3e-05 22.2 0.0 2.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EAK90662.1 - 6.7e-05 21.8 0.1 0.00018 20.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase EF-hand_5 PF13202.6 EAK90662.1 - 0.00068 19.0 2.1 0.74 9.4 0.1 2.7 2 0 0 2 2 2 2 EF hand Kinase-like PF14531.6 EAK90662.1 - 0.0037 16.6 0.0 0.0059 16.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EAK90662.1 - 0.0042 16.7 0.2 0.014 15.0 0.0 1.9 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EAK90662.1 - 0.0046 16.9 0.0 0.025 14.5 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family zf-C3HC4 PF00097.25 EAK90663.1 - 8.2e-06 25.6 9.8 8.2e-06 25.6 9.8 4.8 2 2 2 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EAK90663.1 - 1.1e-05 25.5 8.3 1.1e-05 25.5 8.3 4.9 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EAK90663.1 - 3e-05 23.8 10.8 3e-05 23.8 10.8 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAK90663.1 - 7.3e-05 22.5 14.3 7.3e-05 22.5 14.3 3.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EAK90663.1 - 0.0002 21.3 9.3 0.0002 21.3 9.3 4.4 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_2 PF13639.6 EAK90663.1 - 0.00025 21.3 15.0 0.00025 21.3 15.0 4.1 3 1 2 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 EAK90663.1 - 0.00034 20.5 14.3 0.00034 20.5 14.3 4.2 4 1 1 5 5 5 1 zinc-RING finger domain U-box PF04564.15 EAK90663.1 - 0.0044 17.2 1.3 0.55 10.4 0.3 2.6 2 0 0 2 2 2 1 U-box domain Rubredoxin PF00301.20 EAK90663.1 - 0.0084 16.1 5.2 0.29 11.2 0.1 4.2 4 0 0 4 4 4 1 Rubredoxin NDUFB10 PF10249.9 EAK90663.1 - 5 7.6 7.7 0.55 10.7 0.5 2.6 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase subunit 10 Ribosomal_S11 PF00411.19 EAK90664.1 - 1e-45 154.6 1.3 1.2e-45 154.4 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Dynamitin PF04912.14 EAK90666.1 - 3e-09 36.7 0.2 3.7e-09 36.4 0.2 1.0 1 0 0 1 1 1 1 Dynamitin PerC PF06069.11 EAK90666.1 - 0.1 12.9 0.0 5 7.5 0.0 2.1 1 1 1 2 2 2 0 PerC transcriptional activator VIT1 PF01988.19 EAK90667.1 - 8.5e-48 163.1 0.3 1e-47 162.8 0.3 1.1 1 0 0 1 1 1 1 VIT family Mig-14 PF07395.11 EAK90667.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Mig-14 DUF1129 PF06570.11 EAK90667.1 - 0.17 11.3 3.6 1.1 8.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) EMP70 PF02990.16 EAK90668.1 - 4e-114 382.1 28.5 4e-114 382.1 28.5 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 GBV-C_env PF12786.7 EAK90668.1 - 0.25 10.0 0.5 0.39 9.4 0.5 1.2 1 0 0 1 1 1 0 GB virus C genotype envelope RIO1 PF01163.22 EAK90669.1 - 7.5e-45 152.8 0.1 3.8e-44 150.5 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 EAK90669.1 - 7.8e-32 109.3 0.4 2.1e-31 107.9 0.4 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EAK90669.1 - 4.9e-05 23.4 0.2 0.0048 16.8 0.3 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EAK90669.1 - 0.0014 18.0 0.1 0.017 14.5 0.1 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Nop14 PF04147.12 EAK90669.1 - 0.05 11.8 31.5 0.07 11.3 31.5 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EAK90669.1 - 0.63 8.3 26.9 1.1 7.5 26.9 1.3 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EAK90669.1 - 0.75 7.8 35.8 1.1 7.3 35.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi CPSF100_C PF13299.6 EAK90669.1 - 1.5 9.0 9.0 2.5 8.3 9.0 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RRN3 PF05327.11 EAK90669.1 - 2.4 6.6 19.5 3.5 6.1 19.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GET2 PF08690.10 EAK90669.1 - 2.4 7.7 9.9 3.8 7.1 9.9 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Usp PF00582.26 EAK90669.1 - 3 8.4 10.8 1.1e+02 3.3 0.0 2.2 2 0 0 2 2 2 0 Universal stress protein family BUD22 PF09073.10 EAK90669.1 - 3.8 6.8 31.0 5.1 6.3 31.0 1.1 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 EAK90669.1 - 4.4 6.2 8.7 7 5.5 8.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SLC12 PF03522.15 EAK90669.1 - 7.5 5.5 13.9 3.8 6.4 11.7 1.7 2 0 0 2 2 2 0 Solute carrier family 12 DUF2457 PF10446.9 EAK90669.1 - 8 5.5 37.6 11 5.0 37.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ldh_1_N PF00056.23 EAK90670.1 - 1.1e-42 145.5 0.3 3.2e-42 144.0 0.1 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EAK90670.1 - 1.6e-29 103.0 0.1 2.4e-29 102.4 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain F420_oxidored PF03807.17 EAK90670.1 - 0.00012 22.5 0.1 0.00077 20.0 0.0 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.14 EAK90670.1 - 0.00043 19.9 1.0 0.0036 16.9 0.7 2.5 3 1 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_hydro_4 PF02056.16 EAK90670.1 - 0.01 15.4 1.2 0.037 13.6 0.1 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Shikimate_DH PF01488.20 EAK90670.1 - 0.03 14.4 0.4 0.36 10.9 0.2 2.6 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EAK90670.1 - 0.11 12.4 0.1 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EAK90670.1 - 0.12 11.8 0.1 0.27 10.6 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MIT_C PF16565.5 EAK90670.1 - 0.16 11.9 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT Ldh_1_N PF00056.23 EAK90671.1 - 3.7e-35 121.1 0.3 6.3e-35 120.3 0.3 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EAK90671.1 - 2.7e-24 86.0 0.0 4e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EAK90671.1 - 0.0019 17.8 0.1 0.0079 15.8 0.0 2.0 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase 3HCDH_N PF02737.18 EAK90671.1 - 0.0071 16.2 0.6 0.017 15.0 0.4 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EAK90671.1 - 0.037 13.6 1.3 0.13 11.8 1.3 1.8 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TFIIS_C PF01096.18 EAK90672.1 - 5.8e-21 74.1 2.9 5.8e-21 74.1 2.9 1.5 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 EAK90672.1 - 0.0047 16.6 0.6 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 Baculoviridae late expression factor 5 C-terminal domain DUF2387 PF09526.10 EAK90672.1 - 0.0048 17.0 0.4 0.0061 16.7 0.4 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) Zn_Tnp_IS1595 PF12760.7 EAK90672.1 - 0.0079 16.1 0.5 0.011 15.6 0.5 1.4 1 1 0 1 1 1 1 Transposase zinc-ribbon domain P5-ATPase PF12409.8 EAK90672.1 - 0.031 14.4 0.1 0.036 14.2 0.1 1.2 1 0 0 1 1 1 0 P5-type ATPase cation transporter zf_C2H2_ZHX PF18387.1 EAK90672.1 - 0.21 11.2 2.0 3.8 7.2 0.3 2.2 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain C1_2 PF03107.16 EAK90672.1 - 0.29 11.5 0.1 0.29 11.5 0.1 2.6 2 1 0 2 2 2 0 C1 domain Prefoldin_2 PF01920.20 EAK90673.1 - 1.9e-08 34.2 0.8 2.2e-08 34.0 0.8 1.0 1 0 0 1 1 1 1 Prefoldin subunit HSCB_C PF07743.13 EAK90673.1 - 0.0029 18.1 0.2 0.0038 17.7 0.2 1.2 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DUF4795 PF16043.5 EAK90673.1 - 0.022 14.4 0.5 0.026 14.1 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Mt_ATP-synt_D PF05873.12 EAK90673.1 - 0.025 14.4 0.1 0.027 14.3 0.1 1.1 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) YojJ PF10372.9 EAK90673.1 - 0.039 14.0 1.4 0.039 14.0 1.4 1.9 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF883 PF05957.13 EAK90673.1 - 0.044 14.4 0.1 0.056 14.1 0.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) EF-G-binding_N PF07299.11 EAK90673.1 - 0.053 14.1 0.3 0.072 13.6 0.3 1.2 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal KfrA_N PF11740.8 EAK90673.1 - 0.076 13.7 0.0 0.077 13.7 0.0 1.1 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term Takusan PF04822.13 EAK90673.1 - 0.17 11.8 3.1 1.1 9.1 3.1 2.0 1 1 0 1 1 1 0 Takusan LSM PF01423.22 EAK90674.1 - 9.2e-21 73.3 0.1 1.1e-20 73.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain Metallophos PF00149.28 EAK90676.1 - 1.3e-35 123.8 0.4 2e-35 123.2 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EAK90676.1 - 0.02 15.4 0.4 0.047 14.1 0.4 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 EAK90676.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain PGK PF00162.19 EAK90677.1 - 1.9e-145 484.6 0.7 2.1e-145 484.4 0.7 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF5085 PF16895.5 EAK90677.1 - 0.079 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5085) DUF5053 PF16476.5 EAK90677.1 - 0.15 11.7 0.1 0.54 10.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5053) NARP1 PF12569.8 EAK90678.1 - 9.2e-47 160.1 24.2 2e-40 139.2 13.9 3.2 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EAK90678.1 - 2.4e-09 36.6 11.9 0.00033 20.5 0.0 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EAK90678.1 - 5e-08 33.3 3.0 0.015 15.8 0.0 5.6 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EAK90678.1 - 1.5e-06 28.2 0.5 0.032 14.6 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAK90678.1 - 8.1e-05 22.5 11.0 0.0099 16.0 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EAK90678.1 - 0.00011 22.7 0.0 1.6 9.8 0.0 5.6 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EAK90678.1 - 0.00012 21.7 14.7 0.00078 19.2 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EAK90678.1 - 0.00022 20.8 2.1 0.15 11.7 0.0 4.4 5 0 0 5 5 5 1 TPR repeat TPR_7 PF13176.6 EAK90678.1 - 0.002 18.0 0.3 0.41 10.8 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAK90678.1 - 0.018 15.3 11.2 0.4 10.9 0.5 4.6 3 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Peptidase_S66C PF17676.1 EAK90678.1 - 0.037 14.6 0.0 0.19 12.2 0.0 2.2 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain TPR_12 PF13424.6 EAK90678.1 - 0.07 13.4 1.0 3.7 7.9 0.0 3.8 4 1 1 5 5 4 0 Tetratricopeptide repeat S4 PF01479.25 EAK90679.1 - 1.5e-08 34.2 0.0 2.7e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EAK90679.1 - 5.5e-07 30.4 4.9 1.1e-06 29.4 4.9 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain LSM PF01423.22 EAK90680.1 - 3.6e-14 52.2 2.1 6.5e-14 51.4 2.1 1.4 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EAK90680.1 - 0.0014 18.2 0.4 0.002 17.7 0.4 1.3 1 0 0 1 1 1 1 Hfq protein SM-ATX PF14438.6 EAK90680.1 - 0.033 14.3 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Stn1_C PF12659.7 EAK90680.1 - 0.079 12.9 1.3 0.21 11.6 1.1 1.7 1 1 1 2 2 2 0 Telomere capping C-terminal wHTH zf-CCCH PF00642.24 EAK90681.1 - 2.2e-17 62.5 11.3 2.9e-07 30.2 0.9 3.6 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EAK90681.1 - 7.3e-10 38.4 14.1 5.5e-05 22.9 2.1 3.6 3 0 0 3 3 3 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EAK90681.1 - 1.4e-07 31.3 17.4 3.6e-05 23.7 3.0 4.0 3 1 0 3 3 3 2 Zinc finger domain zf-CCCH_3 PF15663.5 EAK90681.1 - 1.5e-05 25.1 10.1 0.00029 21.0 2.6 2.9 2 1 1 3 3 3 2 Zinc-finger containing family Torus PF16131.5 EAK90681.1 - 0.00016 22.4 15.3 0.00021 22.0 0.9 4.0 3 1 2 5 5 5 2 Torus domain zf-CCCH_2 PF14608.6 EAK90681.1 - 0.16 12.5 14.9 0.55 10.8 0.6 3.7 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Pkinase PF00069.25 EAK90682.1 - 6.7e-59 199.4 0.0 5e-37 127.7 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAK90682.1 - 2.1e-32 112.4 0.0 1.7e-22 80.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_1 PF00036.32 EAK90682.1 - 3.5e-30 101.3 9.5 1.1e-05 24.6 0.1 5.9 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 EAK90682.1 - 4.8e-29 100.6 0.5 3.7e-10 40.1 0.2 3.8 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EAK90682.1 - 1.2e-25 87.1 11.8 1.9e-05 24.2 0.1 5.8 5 0 0 5 5 5 5 EF-hand domain EF-hand_5 PF13202.6 EAK90682.1 - 6.3e-24 82.4 14.2 0.0001 21.6 0.2 5.7 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 EAK90682.1 - 1e-21 76.5 11.3 1.1e-05 25.2 0.0 5.7 4 1 1 5 5 5 5 EF-hand domain pair Kinase-like PF14531.6 EAK90682.1 - 5.1e-06 26.0 0.0 0.11 11.8 0.1 2.6 2 0 0 2 2 2 2 Kinase-like SPARC_Ca_bdg PF10591.9 EAK90682.1 - 8.8e-06 26.0 2.7 0.088 13.1 0.0 4.4 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Kdo PF06293.14 EAK90682.1 - 0.00026 20.4 0.7 0.00083 18.8 0.0 2.1 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Loricrin PF15847.5 EAK90682.1 - 0.0029 16.7 13.5 0.0029 16.7 13.5 2.1 2 0 0 2 2 2 1 Major keratinocyte cell envelope protein Caleosin PF05042.13 EAK90682.1 - 0.031 14.2 0.5 26 4.7 0.0 3.8 2 1 0 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 EAK90682.1 - 0.14 12.2 4.7 2.4 8.2 0.0 3.5 2 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand HTH_Tnp_Mu_2 PF09039.11 EAK90682.1 - 0.15 12.2 0.0 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Mu DNA binding, I gamma subdomain CTP_transf_like PF01467.26 EAK90683.1 - 0.0043 17.3 0.0 0.0079 16.4 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like Peptidase_M16 PF00675.20 EAZ51200.1 - 5.1e-26 91.4 0.0 1.5e-25 89.9 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAZ51200.1 - 3.1e-07 30.6 2.2 3.1e-07 30.6 2.2 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Pkinase PF00069.25 EAZ51201.1 - 1.6e-29 103.1 0.0 2.9e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51201.1 - 2.3e-19 69.7 0.0 3.3e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EAZ51201.1 - 3.8e-09 35.8 0.0 3.8e-09 35.8 0.0 2.5 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EAZ51201.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EAZ51201.1 - 0.0091 15.0 0.3 0.024 13.6 0.0 1.7 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EAZ51201.1 - 0.028 13.8 0.1 0.053 12.9 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family cEGF PF12662.7 EAZ51202.1 - 1.3e-05 25.0 5.4 1.3e-05 25.0 5.4 2.1 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF_3 PF12947.7 EAZ51202.1 - 0.00011 22.3 7.8 0.00011 22.3 7.8 2.7 2 0 0 2 2 2 1 EGF domain EGF_CA PF07645.15 EAZ51202.1 - 0.0034 17.6 10.6 0.0034 17.6 10.6 2.9 3 0 0 3 3 3 2 Calcium-binding EGF domain EGF PF00008.27 EAZ51202.1 - 0.77 10.1 17.1 0.037 14.3 3.4 2.8 2 1 0 2 2 2 0 EGF-like domain Metallophos PF00149.28 EAZ51203.1 - 2.6e-32 113.0 0.7 4.5e-32 112.2 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_5 PF13854.6 EAZ51203.1 - 3.3e-10 39.7 0.2 0.00049 20.0 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EAZ51203.1 - 3.3e-07 30.0 0.7 0.00059 19.7 0.1 3.4 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EAZ51203.1 - 1.1e-06 28.5 2.3 0.13 12.3 0.0 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EAZ51203.1 - 3.8e-06 26.4 0.3 0.07 12.7 0.0 3.2 2 1 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 EAZ51203.1 - 0.00014 22.0 0.0 0.56 10.6 0.0 3.2 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 EAZ51203.1 - 0.012 15.9 0.0 0.012 15.9 0.0 3.7 5 0 0 5 5 5 0 Galactose oxidase, central domain Pkinase PF00069.25 EAZ51204.1 - 4.5e-68 229.5 0.0 4.5e-34 118.0 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51204.1 - 3.9e-27 95.2 0.0 4.2e-15 55.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_6 PF13405.6 EAZ51204.1 - 1.4e-11 43.4 0.6 0.016 15.1 0.1 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EAZ51204.1 - 9.2e-08 32.4 2.8 0.0014 19.1 0.1 4.2 3 1 2 5 5 5 3 EF-hand domain pair EF-hand_1 PF00036.32 EAZ51204.1 - 7.1e-07 28.3 1.0 0.005 16.3 0.1 4.1 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 EAZ51204.1 - 9.1e-07 28.1 0.7 0.0064 15.9 0.2 3.2 3 0 0 3 3 3 2 EF hand Kdo PF06293.14 EAZ51204.1 - 0.01 15.2 0.1 0.018 14.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_8 PF13833.6 EAZ51204.1 - 0.13 12.1 2.6 11 5.9 0.0 4.2 5 0 0 5 5 5 0 EF-hand domain pair Synaptobrevin PF00957.21 EAZ51205.1 - 5.3e-21 74.2 1.3 8.8e-21 73.5 1.3 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EAZ51205.1 - 3.2e-12 46.3 0.1 6.4e-12 45.3 0.1 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain TatD_DNase PF01026.21 EAZ51206.1 - 1.1e-35 123.2 0.0 1.9e-35 122.5 0.0 1.4 1 1 0 1 1 1 1 TatD related DNase Adaptin_N PF01602.20 EAZ51207.1 - 5.6e-59 200.1 26.1 1.7e-49 168.8 17.2 2.1 2 0 0 2 2 2 2 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EAZ51207.1 - 3.1e-35 121.0 4.0 2.3e-33 114.9 4.0 3.1 1 1 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EAZ51207.1 - 5.3e-33 113.9 5.1 1.1e-32 112.8 2.7 2.7 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 EAZ51207.1 - 4.9e-07 29.9 13.7 6.1e-07 29.6 0.8 3.5 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EAZ51207.1 - 0.00012 22.0 0.0 0.041 14.1 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 EAZ51207.1 - 0.00094 19.5 0.0 0.24 11.8 0.0 3.6 3 1 1 4 4 4 1 HEAT repeats RTP1_C1 PF10363.9 EAZ51207.1 - 0.01 16.0 4.0 0.012 15.8 0.1 3.0 2 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Nop53 PF07767.11 EAZ51208.1 - 0.86 8.9 40.1 1.6 8.0 11.1 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Alpha-2-MRAP_C PF06401.11 EAZ51209.1 - 0.14 12.1 5.5 0.21 11.5 5.5 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain ABC_tran PF00005.27 EAZ51210.1 - 7.9e-32 110.6 0.2 1.4e-20 74.2 0.0 3.7 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EAZ51210.1 - 2.4e-15 56.9 30.7 1.8e-14 54.0 13.7 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EAZ51210.1 - 4.3e-07 29.6 3.6 0.079 12.4 0.0 4.2 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EAZ51210.1 - 3.3e-06 27.2 0.0 0.019 15.1 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAZ51210.1 - 1.1e-05 25.4 0.3 0.018 15.0 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EAZ51210.1 - 4.8e-05 23.0 0.6 0.034 13.9 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EAZ51210.1 - 0.00012 22.5 0.1 0.021 15.2 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 EAZ51210.1 - 0.00056 19.1 0.2 0.086 11.9 0.1 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 EAZ51210.1 - 0.0008 19.0 0.2 0.078 12.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region cobW PF02492.19 EAZ51210.1 - 0.0016 18.1 0.8 0.65 9.6 0.0 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EAZ51210.1 - 0.0032 17.8 0.3 2.7 8.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EAZ51210.1 - 0.0034 17.1 0.3 3.8 7.3 0.0 2.7 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Viral_helicase1 PF01443.18 EAZ51210.1 - 0.0047 16.7 1.9 1.6 8.4 0.0 3.2 4 0 0 4 4 3 1 Viral (Superfamily 1) RNA helicase Dynamin_N PF00350.23 EAZ51210.1 - 0.018 15.1 1.8 1.9 8.5 0.1 2.8 2 0 0 2 2 2 0 Dynamin family RNA_helicase PF00910.22 EAZ51210.1 - 0.089 13.2 2.8 6.5 7.2 0.0 3.5 3 0 0 3 3 3 0 RNA helicase ATPase_2 PF01637.18 EAZ51210.1 - 0.092 12.6 1.4 4.1 7.2 0.0 3.3 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AIG1 PF04548.16 EAZ51210.1 - 0.11 11.7 1.1 4.3 6.6 0.0 2.7 2 0 0 2 2 2 0 AIG1 family NB-ARC PF00931.22 EAZ51210.1 - 0.13 11.4 0.1 11 5.1 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain TrwB_AAD_bind PF10412.9 EAZ51210.1 - 0.16 10.8 0.4 3.6 6.4 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Roc PF08477.13 EAZ51210.1 - 0.17 12.1 2.2 47 4.2 0.0 3.7 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 EAZ51210.1 - 0.22 10.8 0.1 14 4.9 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EAZ51210.1 - 0.22 11.4 2.1 23 4.8 0.0 2.9 3 0 0 3 3 2 0 NTPase AAA_28 PF13521.6 EAZ51210.1 - 0.39 10.9 1.3 4.1 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EAZ51210.1 - 0.5 10.4 5.7 0.33 11.0 1.0 2.9 2 1 1 3 3 3 0 Helicase HerA, central domain MobB PF03205.14 EAZ51210.1 - 0.52 10.2 1.4 17 5.3 0.6 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 EAZ51210.1 - 0.72 9.8 3.8 17 5.3 0.0 3.2 3 0 0 3 3 3 0 NACHT domain AAA_18 PF13238.6 EAZ51210.1 - 0.96 10.0 5.6 24 5.5 0.0 3.5 4 0 0 4 4 3 0 AAA domain Ribosomal_L29e PF01779.17 EAZ51211.1 - 4.5e-19 68.5 12.0 6.4e-19 68.0 12.0 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family WD40 PF00400.32 EAZ51212.1 - 1.6e-59 196.4 30.2 1.3e-10 41.7 0.0 9.6 8 2 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51212.1 - 9.5e-20 70.7 7.0 0.00069 19.9 0.2 6.2 3 3 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EAZ51212.1 - 7.1e-08 31.8 1.8 0.44 9.5 0.0 5.0 2 2 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EAZ51212.1 - 1.2e-07 31.9 0.1 0.00066 19.6 0.0 3.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EAZ51212.1 - 5.6e-07 28.6 6.5 0.031 12.9 0.5 4.7 4 1 0 4 4 4 3 Nucleoporin Nup120/160 NLE PF08154.12 EAZ51212.1 - 2.9e-06 27.7 0.8 5.9e-06 26.7 0.8 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain DPPIV_N PF00930.21 EAZ51212.1 - 0.0016 17.3 1.7 0.45 9.2 0.0 3.8 4 0 0 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nbas_N PF15492.6 EAZ51212.1 - 0.0019 17.6 1.3 14 4.9 0.0 4.1 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 EAZ51212.1 - 0.0041 15.5 0.0 0.36 9.1 0.0 2.3 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 EAZ51212.1 - 0.03 13.3 10.1 0.3 10.0 0.0 3.9 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 EAZ51212.1 - 0.077 13.0 4.4 2.6 8.1 0.1 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat CoaE PF01121.20 EAZ51213.1 - 3e-15 56.3 0.0 3.4e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase NPIP PF06409.11 EAZ51213.1 - 0.063 12.3 0.0 0.074 12.1 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Clathrin PF00637.20 EAZ51214.1 - 9.7e-08 32.0 12.0 1.7e-07 31.2 6.3 2.7 2 1 0 2 2 2 2 Region in Clathrin and VPS DASH_Dad4 PF08650.10 EAZ51214.1 - 0.0081 16.1 0.1 0.039 13.9 0.1 2.2 1 0 0 1 1 1 1 DASH complex subunit Dad4 SEP PF08059.13 EAZ51215.1 - 2.4e-22 79.3 0.2 6.2e-22 78.0 0.1 1.7 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EAZ51215.1 - 2.6e-09 37.1 0.0 5e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 UBX domain Peptidase_M6 PF05547.11 EAZ51215.1 - 0.0016 16.8 0.1 0.002 16.6 0.1 1.1 1 0 0 1 1 1 1 Immune inhibitor A peptidase M6 NEAT PF05031.12 EAZ51215.1 - 0.17 12.5 1.4 11 6.7 0.1 2.4 1 1 1 2 2 2 0 Iron Transport-associated domain Coatomer_E PF04733.14 EAZ51216.1 - 3.7e-13 49.5 2.0 9.5e-11 41.6 2.0 2.4 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_2 PF07719.17 EAZ51216.1 - 0.0031 17.5 0.0 0.073 13.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Abhydrolase_1 PF00561.20 EAZ51217.1 - 6.4e-11 42.4 0.0 8.7e-09 35.4 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EAZ51217.1 - 3.5e-05 23.2 0.0 0.002 17.4 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EAZ51217.1 - 0.001 17.8 0.0 0.0019 17.0 0.0 1.3 1 0 0 1 1 1 1 Ndr family Ham1p_like PF01725.16 EAZ51218.1 - 1.7e-45 155.3 0.0 2e-45 155.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family TrkH PF02386.16 EAZ51218.1 - 0.0091 14.5 0.3 0.013 14.0 0.3 1.1 1 0 0 1 1 1 1 Cation transport protein HA2 PF04408.23 EAZ51219.1 - 3.3e-18 65.9 0.2 8.4e-17 61.4 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EAZ51219.1 - 6.8e-16 58.4 0.1 3.4e-15 56.2 0.1 2.2 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EAZ51219.1 - 1.6e-11 44.5 0.1 1.6e-11 44.5 0.1 3.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EAZ51219.1 - 2.5e-09 37.2 0.4 3.2e-08 33.6 0.1 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EAZ51219.1 - 3.4e-05 24.1 0.0 0.00012 22.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EAZ51219.1 - 0.00067 19.5 0.8 0.0026 17.7 0.0 2.3 2 0 0 2 2 2 1 Helicase AAA_23 PF13476.6 EAZ51219.1 - 0.00075 20.1 15.2 0.0031 18.1 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EAZ51219.1 - 0.00093 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EAZ51219.1 - 0.001 18.8 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EAZ51219.1 - 0.0036 17.8 1.7 0.0078 16.7 0.0 2.5 3 1 0 3 3 3 1 ABC transporter AAA_19 PF13245.6 EAZ51219.1 - 0.0066 16.8 0.1 0.029 14.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EAZ51219.1 - 0.0099 15.8 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase PhoH PF02562.16 EAZ51219.1 - 0.021 14.3 0.0 0.074 12.5 0.0 2.1 1 1 0 1 1 1 0 PhoH-like protein MMR_HSR1 PF01926.23 EAZ51219.1 - 0.025 14.7 0.1 0.46 10.6 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 EAZ51219.1 - 0.03 13.7 0.9 0.089 12.2 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain SMC_ScpB PF04079.16 EAZ51219.1 - 0.045 13.4 0.1 0.098 12.3 0.1 1.5 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB ATPase PF06745.13 EAZ51219.1 - 0.05 12.9 0.1 0.19 11.0 0.0 2.0 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 EAZ51219.1 - 0.063 13.2 0.0 0.28 11.1 0.0 2.3 1 1 0 1 1 1 0 NACHT domain T2SSE PF00437.20 EAZ51219.1 - 0.088 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 EAZ51219.1 - 9 6.1 9.7 0.2 11.6 0.2 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EAZ51220.1 - 4.7e-29 101.6 0.1 1.8e-17 64.1 0.0 3.0 2 1 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 EAZ51220.1 - 9.6e-07 29.3 0.0 0.0042 17.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EAZ51220.1 - 1e-06 28.3 0.2 0.012 15.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain NB-ARC PF00931.22 EAZ51220.1 - 1.3e-06 27.8 2.7 0.0029 16.8 0.0 3.4 4 1 0 4 4 3 2 NB-ARC domain ABC_membrane PF00664.23 EAZ51220.1 - 1.6e-06 28.0 18.8 1.6e-06 28.0 18.8 2.4 2 0 0 2 2 2 1 ABC transporter transmembrane region RsgA_GTPase PF03193.16 EAZ51220.1 - 1e-05 25.5 1.7 0.074 13.0 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_7 PF12775.7 EAZ51220.1 - 8.2e-05 22.2 0.3 0.17 11.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 EAZ51220.1 - 9.8e-05 22.6 3.2 0.19 12.0 0.0 3.6 4 1 0 4 4 3 2 AAA domain DUF87 PF01935.17 EAZ51220.1 - 0.00028 21.0 4.9 0.003 17.7 0.2 3.7 3 0 0 3 3 3 1 Helicase HerA, central domain RNA_helicase PF00910.22 EAZ51220.1 - 0.00032 21.1 0.2 1.1 9.7 0.0 3.2 2 0 0 2 2 2 2 RNA helicase MMR_HSR1 PF01926.23 EAZ51220.1 - 0.00032 20.7 0.1 0.029 14.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 EAZ51220.1 - 0.00033 20.2 5.4 0.033 13.6 0.5 2.9 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EAZ51220.1 - 0.00053 20.2 0.0 0.002 18.3 0.0 2.0 2 0 0 2 2 1 1 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EAZ51220.1 - 0.00065 19.6 1.2 0.3 11.0 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA PF00004.29 EAZ51220.1 - 0.00067 20.1 0.1 1.9 8.9 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EAZ51220.1 - 0.0011 19.5 0.8 0.0011 19.5 0.8 4.0 3 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EAZ51220.1 - 0.0019 17.5 0.0 0.12 11.7 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin FtsK_SpoIIIE PF01580.18 EAZ51220.1 - 0.0024 17.3 0.0 0.11 11.9 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family TsaE PF02367.17 EAZ51220.1 - 0.0032 17.5 0.0 2 8.4 0.0 2.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EAZ51220.1 - 0.0077 15.3 0.1 0.17 10.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MobB PF03205.14 EAZ51220.1 - 0.0078 16.1 0.7 1.7 8.6 0.0 2.9 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.6 EAZ51220.1 - 0.0081 15.9 0.0 0.34 10.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EAZ51220.1 - 0.0082 15.3 0.1 0.67 9.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 EAZ51220.1 - 0.017 15.1 0.4 7.9 6.4 0.2 2.5 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 EAZ51220.1 - 0.018 15.4 0.1 14 6.0 0.0 3.3 4 0 0 4 4 3 0 AAA domain Viral_helicase1 PF01443.18 EAZ51220.1 - 0.034 13.9 0.0 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.9 EAZ51220.1 - 0.036 13.0 0.2 5.1 5.9 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DAP3 PF10236.9 EAZ51220.1 - 0.051 12.7 0.5 0.58 9.3 0.0 2.5 2 1 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 EAZ51220.1 - 0.094 11.9 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 EAZ51220.1 - 0.14 12.2 0.1 13 5.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.19 EAZ51220.1 - 0.14 11.7 1.8 0.8 9.3 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ResIII PF04851.15 EAZ51220.1 - 0.32 11.0 3.3 1.4 8.9 0.0 3.3 3 1 0 3 3 2 0 Type III restriction enzyme, res subunit PduV-EutP PF10662.9 EAZ51220.1 - 0.53 10.0 5.1 13 5.6 0.5 3.4 2 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation UQ_con PF00179.26 EAZ51221.1 - 8.9e-30 103.2 0.1 1.2e-29 102.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EAZ51221.1 - 0.0046 17.2 0.1 0.0073 16.6 0.1 1.5 1 1 0 1 1 1 1 RWD domain RNase_PH PF01138.21 EAZ51222.1 - 4.3e-12 46.7 0.1 2.6e-11 44.2 0.1 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EAZ51222.1 - 0.026 14.6 1.3 0.054 13.5 0.1 2.1 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 MutS_V PF00488.21 EAZ51223.1 - 3.5e-71 239.1 0.1 6.9e-71 238.2 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EAZ51223.1 - 1.3e-32 112.4 0.0 3.2e-32 111.1 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 EAZ51223.1 - 4.4e-28 98.8 0.2 4.4e-28 98.8 0.2 2.6 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EAZ51223.1 - 6.4e-05 23.2 2.4 0.00022 21.5 2.4 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EAZ51223.1 - 0.0029 17.9 0.0 0.014 15.7 0.0 2.2 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 EAZ51223.1 - 0.072 12.7 0.1 15 5.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Defb50 PF17546.2 EAZ51223.1 - 0.73 9.8 3.0 0.71 9.8 0.7 2.2 2 0 0 2 2 2 0 Beta defensin 50 EBP PF05241.12 EAZ51224.1 - 0.092 12.2 1.7 0.22 11.0 0.7 1.9 1 1 1 2 2 2 0 Emopamil binding protein UQ_con PF00179.26 EAZ51225.1 - 1.4e-15 57.2 0.0 1.5e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EAZ51225.1 - 0.0059 16.9 0.0 0.0059 16.9 0.0 1.2 1 0 0 1 1 1 1 RWD domain Thymidylate_kin PF02223.17 EAZ51226.1 - 1.5e-25 90.0 0.0 1.9e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase Sec1 PF00995.23 EAZ51227.1 - 2.6e-106 357.2 18.8 2.9e-106 357.0 18.8 1.0 1 0 0 1 1 1 1 Sec1 family DUF4874 PF16173.5 EAZ51227.1 - 0.023 14.4 0.1 0.11 12.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) Metallophos PF00149.28 EAZ51229.1 - 1.7e-28 100.5 0.2 2.2e-28 100.2 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EAZ51229.1 - 0.00048 20.5 1.5 0.0016 18.8 1.5 1.9 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain TIR_3 PF18567.1 EAZ51229.1 - 0.02 14.9 0.2 0.039 13.9 0.2 1.4 1 0 0 1 1 1 0 Toll/interleukin-1 receptor domain DUF4279 PF14106.6 EAZ51229.1 - 0.083 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) Sec1 PF00995.23 EAZ51230.1 - 3.4e-81 274.2 10.8 3.9e-81 274.0 10.8 1.0 1 0 0 1 1 1 1 Sec1 family EarP PF10093.9 EAZ51230.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP tRNA-synt_1d PF00750.19 EAZ51231.1 - 7e-112 373.8 1.5 9.3e-111 370.1 1.5 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EAZ51231.1 - 6.8e-28 97.2 0.1 1.2e-27 96.4 0.1 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EAZ51231.1 - 5.5e-20 71.7 0.5 1.5e-19 70.3 0.5 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EAZ51231.1 - 0.00087 18.7 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 EAZ51231.1 - 0.052 11.8 0.0 0.098 10.9 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EAZ51231.1 - 0.078 11.7 0.0 0.21 10.3 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (M) AJAP1_PANP_C PF15298.6 EAZ51232.1 - 0.00021 21.6 15.5 0.00048 20.4 15.5 1.5 1 0 0 1 1 1 1 AJAP1/PANP C-terminus Dicty_REP PF05086.12 EAZ51232.1 - 0.0097 14.0 12.3 0.016 13.3 12.3 1.2 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 EAZ51232.1 - 0.074 13.0 43.8 0.16 12.0 43.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein TT_ORF1 PF02956.14 EAZ51232.1 - 0.34 9.6 8.4 0.19 10.3 0.3 2.3 2 0 0 2 2 2 0 TT viral orf 1 DUF2500 PF10694.9 EAZ51234.1 - 0.16 12.5 1.5 2.2 8.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Mito_carr PF00153.27 EAZ51235.1 - 1.4e-22 79.4 0.2 1.1e-09 38.1 0.0 3.2 2 1 0 2 2 2 2 Mitochondrial carrier protein MtrD PF04207.12 EAZ51235.1 - 0.17 11.5 0.0 0.87 9.2 0.0 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit D Pkinase PF00069.25 EAZ51236.1 - 9.9e-59 198.8 0.0 1.4e-58 198.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51236.1 - 4.2e-18 65.6 0.0 2.2e-13 50.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51236.1 - 0.00027 20.4 0.0 0.033 13.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Choline_kinase PF01633.20 EAZ51236.1 - 0.0034 17.0 0.1 0.0058 16.2 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EAZ51236.1 - 0.015 14.6 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAZ51236.1 - 0.017 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EAZ51236.1 - 0.17 11.5 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Ras PF00071.22 EAZ51237.1 - 1.1e-59 200.7 0.1 1.3e-59 200.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51237.1 - 1.1e-35 122.5 0.0 1.6e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51237.1 - 5.5e-14 52.0 0.0 7.7e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51237.1 - 5e-07 29.8 0.0 8.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAZ51237.1 - 0.00012 22.1 0.0 0.024 14.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EAZ51237.1 - 0.0019 17.8 0.0 0.0048 16.5 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EAZ51237.1 - 0.0031 17.9 0.0 0.0057 17.0 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EAZ51237.1 - 0.0035 17.6 0.1 0.042 14.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 EAZ51237.1 - 0.0036 16.7 0.0 0.0045 16.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EAZ51237.1 - 0.0048 16.7 0.0 0.015 15.0 0.0 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EAZ51237.1 - 0.021 14.3 0.0 0.038 13.4 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EAZ51237.1 - 0.025 14.3 0.1 0.054 13.2 0.0 1.6 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EAZ51237.1 - 0.038 14.5 0.4 0.089 13.3 0.4 2.0 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EAZ51237.1 - 0.059 12.8 0.1 0.18 11.2 0.0 1.8 2 1 0 2 2 2 0 Bacterial TniB protein AAA_14 PF13173.6 EAZ51237.1 - 0.076 13.1 0.0 0.2 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EAZ51237.1 - 0.16 11.5 0.0 1.4 8.5 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_21 PF13304.6 EAZ51237.1 - 0.19 11.5 0.7 0.4 10.4 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Bromodomain PF00439.25 EAZ51238.1 - 0.056 13.5 2.5 0.29 11.2 0.7 2.9 2 0 0 2 2 2 0 Bromodomain HSA PF07529.13 EAZ51239.1 - 4.5e-12 46.1 0.7 4.5e-12 46.1 0.7 4.1 4 0 0 4 4 4 1 HSA Myb_DNA-binding PF00249.31 EAZ51239.1 - 0.023 14.9 0.0 0.084 13.1 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Peptidase_S24 PF00717.23 EAZ51240.1 - 0.00087 19.2 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EAZ51240.1 - 0.0011 18.8 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 COMP PF11598.8 EAZ51241.1 - 3.5 8.2 6.5 19 5.8 0.1 3.6 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein AhpC-TSA PF00578.21 EAZ51242.1 - 1.5e-39 134.8 0.0 1.9e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EAZ51242.1 - 3.2e-20 72.3 0.0 3.9e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EAZ51242.1 - 1.9e-12 46.8 0.0 4.7e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 EAZ51242.1 - 0.00033 20.6 0.0 0.00075 19.4 0.0 1.5 2 0 0 2 2 2 1 SCO1/SenC SF3b10 PF07189.11 EAZ51243.1 - 4.5e-23 81.2 0.2 4.9e-23 81.0 0.2 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) RRM_1 PF00076.22 EAZ51244.1 - 5.4e-17 61.4 0.8 1.3e-16 60.2 0.4 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 EAZ51244.1 - 2.9e-06 27.7 0.2 2.9e-06 27.7 0.2 2.0 3 0 0 3 3 3 1 Eukaryotic translation initiation factor 3 subunit G L_lac_phage_MSP PF06488.11 EAZ51244.1 - 0.0076 15.6 0.3 0.016 14.5 0.3 1.5 1 0 0 1 1 1 1 Phage tail tube protein ComGF PF15980.5 EAZ51244.1 - 0.075 13.4 0.2 0.075 13.4 0.2 2.7 2 1 0 3 3 3 0 Putative Competence protein ComGF RRM_7 PF16367.5 EAZ51244.1 - 0.09 12.9 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif zf-MYND PF01753.18 EAZ51245.1 - 4.1e-11 42.8 15.2 7.3e-11 42.0 15.2 1.4 1 0 0 1 1 1 1 MYND finger Myb_DNA-bind_7 PF15963.5 EAZ51245.1 - 0.12 12.3 1.6 0.56 10.1 0.2 2.2 2 0 0 2 2 2 0 Myb DNA-binding like zf-C6H2 PF15801.5 EAZ51245.1 - 0.13 12.6 12.0 0.32 11.3 12.0 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Zn_ribbon_17 PF17120.5 EAZ51245.1 - 0.84 9.3 9.7 1.7 8.3 7.8 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RCC1 PF00415.18 EAZ51246.1 - 1.9e-40 137.2 0.2 1.3e-05 25.7 0.0 9.1 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EAZ51246.1 - 3.8e-22 77.5 27.6 7.4e-09 35.2 0.3 8.1 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat DUF2052 PF09747.9 EAZ51246.1 - 0.028 14.5 0.5 0.028 14.5 0.5 5.0 3 1 1 4 4 4 0 Coiled-coil domain containing protein (DUF2052) LSM PF01423.22 EAZ51247.1 - 1.3e-15 56.9 0.2 1.9e-15 56.3 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EAZ51247.1 - 0.0057 16.3 0.1 0.0086 15.7 0.1 1.3 1 0 0 1 1 1 1 Hfq protein YabP PF07873.11 EAZ51247.1 - 0.047 13.5 0.1 0.49 10.2 0.1 2.1 2 0 0 2 2 2 0 YabP family CBFD_NFYB_HMF PF00808.23 EAZ51248.1 - 4e-15 55.8 0.0 2.1e-14 53.5 0.0 2.2 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EAZ51248.1 - 0.0051 17.2 1.4 0.01 16.2 0.0 2.2 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 Phospholip_A2_3 PF09056.11 EAZ51248.1 - 2.9 8.6 12.8 0.1 13.2 5.5 2.3 2 2 1 3 3 3 0 Prokaryotic phospholipase A2 Rad51 PF08423.11 EAZ51249.1 - 1.9e-15 56.8 0.0 2.2e-15 56.6 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_22 PF13401.6 EAZ51249.1 - 0.00032 21.0 0.0 0.00038 20.7 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EAZ51249.1 - 0.00077 20.0 0.3 0.001 19.6 0.3 1.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EAZ51249.1 - 0.00084 19.8 0.1 0.0011 19.4 0.1 1.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EAZ51249.1 - 0.027 14.8 0.0 0.037 14.4 0.0 1.4 1 1 0 1 1 1 0 RNA helicase ATPase PF06745.13 EAZ51249.1 - 0.045 13.1 1.3 0.081 12.3 1.3 1.7 1 1 0 1 1 1 0 KaiC AAA_33 PF13671.6 EAZ51249.1 - 0.054 13.7 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EAZ51249.1 - 0.079 13.4 0.1 0.13 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain Peptidase_C1 PF00112.23 EAZ51250.1 - 2.7e-41 142.0 3.6 7.7e-41 140.6 3.6 1.7 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EAZ51250.1 - 5.4e-13 49.3 2.3 5.1e-07 30.0 1.2 3.3 2 1 0 2 2 2 2 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EAZ51250.1 - 0.034 12.9 0.4 0.034 12.9 0.4 1.5 2 0 0 2 2 2 0 Peptidase C1-like family RNase_HII PF01351.18 EAZ51251.1 - 2.7e-13 50.2 0.0 1.5e-12 47.8 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease HII HTH_19 PF12844.7 EAZ51251.1 - 0.096 12.7 0.0 0.22 11.5 0.0 1.5 2 0 0 2 2 2 0 Helix-turn-helix domain SMC_N PF02463.19 EAZ51252.1 - 1.6e-57 194.5 37.1 8e-29 100.6 25.8 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EAZ51252.1 - 3.6e-19 69.2 0.0 1.4e-18 67.3 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EAZ51252.1 - 5.7e-15 56.4 9.1 5.7e-15 56.4 9.1 6.9 2 2 3 5 5 1 1 AAA domain AAA_21 PF13304.6 EAZ51252.1 - 2.1e-07 31.0 27.5 4.1e-05 23.5 3.0 5.2 3 2 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system Lebercilin PF15619.6 EAZ51252.1 - 3.1e-06 27.0 24.4 3.1e-06 27.0 24.4 6.0 2 2 4 6 6 6 2 Ciliary protein causing Leber congenital amaurosis disease AAA_29 PF13555.6 EAZ51252.1 - 0.0002 21.1 0.1 0.00048 19.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 EAZ51252.1 - 0.0028 16.6 17.5 0.0028 16.6 17.5 6.1 2 2 3 6 6 6 2 Spc7 kinetochore protein DUF745 PF05335.13 EAZ51252.1 - 0.0068 16.2 4.6 0.0068 16.2 4.6 5.2 3 2 4 7 7 7 1 Protein of unknown function (DUF745) FdhE PF04216.12 EAZ51252.1 - 0.52 10.1 5.7 0.59 10.0 3.9 2.0 1 1 0 1 1 1 0 Protein involved in formate dehydrogenase formation Bcr-Abl_Oligo PF09036.10 EAZ51252.1 - 4.6 7.3 10.4 6 7.0 0.4 4.6 4 0 0 4 4 4 0 Bcr-Abl oncoprotein oligomerisation domain AAA_15 PF13175.6 EAZ51252.1 - 5 6.7 112.6 0.096 12.4 46.9 4.8 2 2 1 3 3 2 0 AAA ATPase domain Pox_A_type_inc PF04508.12 EAZ51252.1 - 8.4 6.4 8.3 12 5.9 0.2 4.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat adh_short PF00106.25 EAZ51253.1 - 2.9e-31 108.4 0.0 2.3e-25 89.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EAZ51253.1 - 1.2e-15 57.8 0.0 5.6e-14 52.3 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EAZ51253.1 - 3.3e-09 36.9 0.0 4.7e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EAZ51253.1 - 0.0011 18.5 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ThiF PF00899.21 EAZ51253.1 - 0.0019 17.6 0.1 0.0032 16.9 0.1 1.3 1 0 0 1 1 1 1 ThiF family Polysacc_synt_2 PF02719.15 EAZ51253.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PFU PF09070.11 EAZ51254.1 - 1.8e-18 66.8 0.3 5.7e-18 65.2 0.3 1.8 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EAZ51254.1 - 1.9e-18 66.4 21.3 9.4e-05 23.1 0.5 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat PUL PF08324.11 EAZ51254.1 - 9e-17 61.2 3.1 1.6e-16 60.4 3.1 1.3 1 0 0 1 1 1 1 PUL domain GDPD PF03009.17 EAZ51255.1 - 4.9e-42 144.4 0.0 6.6e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 EAZ51255.1 - 0.07 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain GDP_Man_Dehyd PF16363.5 EAZ51256.1 - 7.8e-57 193.1 0.0 8.9e-57 193.0 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EAZ51256.1 - 1.6e-48 165.3 0.0 2e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EAZ51256.1 - 1e-15 57.5 0.0 1.7e-15 56.8 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EAZ51256.1 - 1.3e-15 57.4 0.0 1.2e-14 54.1 0.0 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EAZ51256.1 - 1e-09 37.9 0.0 1.6e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EAZ51256.1 - 1.3e-05 25.2 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EAZ51256.1 - 1.4e-05 24.4 0.0 0.00052 19.3 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EAZ51256.1 - 1.4e-05 24.6 0.0 3.4e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EAZ51256.1 - 0.0025 17.7 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EAZ51256.1 - 0.057 13.0 0.0 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 NmrA-like family UDPG_MGDP_dh_N PF03721.14 EAZ51256.1 - 0.069 12.7 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Chal_sti_synt_N PF00195.19 EAZ51256.1 - 0.071 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain adh_short_C2 PF13561.6 EAZ51256.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase LSM PF01423.22 EAZ51257.1 - 0.00044 19.9 0.8 0.00068 19.3 0.8 1.3 1 0 0 1 1 1 1 LSM domain HDA2-3 PF11496.8 EAZ51257.1 - 0.052 12.7 0.0 0.054 12.7 0.0 1.0 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 ALG11_N PF15924.5 EAZ51258.1 - 1.1e-35 123.6 4.8 5.7e-35 121.3 1.3 2.7 2 1 0 2 2 2 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EAZ51258.1 - 2.7e-12 46.6 0.0 7.8e-12 45.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Phage_min_cap2 PF06152.11 EAZ51258.1 - 0.017 14.0 0.1 0.029 13.3 0.1 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 LSM PF01423.22 EAZ51260.1 - 3.5e-18 65.1 0.2 4.8e-18 64.6 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EAZ51260.1 - 0.019 14.6 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Hfq protein RNA_pol_L_2 PF13656.6 EAZ51261.1 - 6.2e-16 57.9 0.0 9.3e-16 57.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_N PF01194.17 EAZ51262.1 - 7.6e-30 103.0 0.2 9e-30 102.8 0.2 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit HSP70 PF00012.20 EAZ51263.1 - 6.5e-115 384.6 1.8 1.4e-114 383.5 0.1 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EAZ51263.1 - 0.0011 17.8 3.4 0.002 17.0 0.0 2.4 3 0 0 3 3 3 1 MreB/Mbl protein Spectrin_like PF18373.1 EAZ51263.1 - 2.6 8.2 6.3 0.79 9.8 0.1 3.2 3 1 1 4 4 4 0 Spectrin like domain Pkinase PF00069.25 EAZ51264.1 - 6.4e-69 232.2 0.0 1.1e-68 231.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51264.1 - 1.8e-40 138.9 0.0 3.3e-40 138.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 EAZ51264.1 - 3.2e-32 110.8 1.4 8.9e-11 42.1 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 EAZ51264.1 - 5.2e-31 103.9 11.0 1.1e-05 24.6 0.1 6.9 7 0 0 7 7 6 5 EF hand EF-hand_6 PF13405.6 EAZ51264.1 - 5.6e-28 94.4 8.6 3.2e-05 23.5 0.1 7.0 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.6 EAZ51264.1 - 1.6e-19 69.5 6.8 1.4e-05 24.9 0.2 5.5 5 1 1 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.6 EAZ51264.1 - 7e-18 63.3 4.3 1.7e-06 27.3 0.2 5.0 5 0 0 5 5 5 3 EF hand Kdo PF06293.14 EAZ51264.1 - 4.4e-06 26.2 0.3 8.2e-06 25.3 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.9 EAZ51264.1 - 5.3e-06 26.7 1.6 0.039 14.3 0.0 3.8 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EAZ51264.1 - 5e-05 23.2 2.6 0.81 9.7 0.0 4.7 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand Kinase-like PF14531.6 EAZ51264.1 - 5.5e-05 22.6 0.2 0.00032 20.1 0.2 2.0 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51264.1 - 6.8e-05 21.8 0.3 9.8e-05 21.3 0.3 1.4 1 1 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EAZ51264.1 - 0.0002 20.5 0.5 0.00039 19.5 0.5 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase EF-hand_10 PF14788.6 EAZ51264.1 - 0.0019 18.0 0.4 0.11 12.4 0.0 4.0 5 0 0 5 5 5 1 EF hand Choline_kinase PF01633.20 EAZ51264.1 - 0.0049 16.5 0.1 0.014 15.0 0.1 1.7 1 0 0 1 1 1 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 EAZ51264.1 - 0.0061 16.1 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 EAZ51264.1 - 0.0071 16.3 0.1 0.41 10.5 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Mob1_phocein PF03637.17 EAZ51265.1 - 3e-46 157.5 2.3 5e-46 156.8 2.3 1.4 1 0 0 1 1 1 1 Mob1/phocein family RRM_1 PF00076.22 EAZ51266.1 - 2.3e-47 158.7 0.1 1.7e-14 53.4 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 EAZ51266.1 - 5e-10 39.3 1.9 1.4e-09 37.8 1.9 1.8 1 0 0 1 1 1 1 WW domain RRM_5 PF13893.6 EAZ51266.1 - 5.5e-10 38.9 0.1 0.0054 16.3 0.0 3.5 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAZ51266.1 - 7.6e-08 32.4 0.2 0.067 13.3 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif RNA_bind PF08675.11 EAZ51266.1 - 0.0005 20.1 0.0 4 7.5 0.0 3.5 3 0 0 3 3 3 2 RNA binding domain SPC12 PF06645.13 EAZ51267.1 - 1.8e-11 44.0 2.2 3.1e-11 43.2 2.2 1.4 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF5510 PF17629.2 EAZ51267.1 - 0.036 14.0 1.0 0.056 13.4 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5510) RabGAP-TBC PF00566.18 EAZ51268.1 - 1.3e-29 103.4 9.7 1.3e-29 103.4 9.7 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Phage_pRha PF09669.10 EAZ51268.1 - 0.051 14.1 2.0 0.89 10.2 0.0 2.7 2 1 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) ArfGap PF01412.18 EAZ51269.1 - 6.2e-24 84.3 0.8 6.2e-24 84.3 0.8 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EAZ51269.1 - 0.00016 21.7 1.5 0.00028 21.0 1.5 1.4 1 0 0 1 1 1 1 B-box zinc finger DUF5401 PF17380.2 EAZ51270.1 - 0.15 10.1 12.1 0.26 9.3 12.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Pkinase PF00069.25 EAZ51271.1 - 1.1e-41 143.0 0.0 2.5e-41 141.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51271.1 - 3.5e-20 72.4 0.0 6.3e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_1 PF00515.28 EAZ51273.1 - 3.2e-05 23.6 2.5 0.0081 16.0 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EAZ51273.1 - 0.00011 22.0 0.2 0.34 11.1 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EAZ51273.1 - 0.0016 18.1 3.3 0.0023 17.6 1.0 2.2 3 0 0 3 3 3 1 TPR repeat Fis1_TPR_C PF14853.6 EAZ51273.1 - 0.0067 16.5 0.6 0.084 13.0 0.0 2.3 2 1 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat Fringe PF02434.16 EAZ51274.1 - 1.1e-15 57.7 3.4 1.7e-08 34.2 0.2 3.0 2 1 1 3 3 3 3 Fringe-like Beta-Casp PF10996.8 EAZ51275.1 - 0.0016 18.7 0.0 0.0084 16.4 0.0 2.3 1 0 0 1 1 1 1 Beta-Casp domain tRNA-synt_1 PF00133.22 EAZ51277.1 - 1.3e-17 63.3 0.1 2.1e-16 59.3 0.1 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EAZ51277.1 - 6.3e-09 35.6 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EAZ51277.1 - 2.8e-07 29.6 0.7 9.7e-06 24.6 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) WD40 PF00400.32 EAZ51278.1 - 4.6e-14 52.6 0.6 4.6e-05 24.1 0.0 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51278.1 - 0.0074 16.6 0.0 7.7 6.9 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EAZ51278.1 - 0.045 12.7 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RNA_pol_Rpb1_5 PF04998.17 EAZ51279.1 - 1.8e-60 204.6 0.1 5.5e-60 203.0 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EAZ51279.1 - 1.1e-58 198.2 0.0 2.4e-58 197.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EAZ51279.1 - 3.4e-29 101.8 0.8 1e-28 100.2 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EAZ51279.1 - 1.4e-24 87.1 0.6 1.4e-24 87.1 0.6 3.6 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EAZ51279.1 - 7.3e-16 58.1 3.0 9.3e-16 57.7 0.1 2.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 C2 PF00168.30 EAZ51280.1 - 2.6e-08 34.1 0.0 4.1e-06 27.0 0.0 3.3 2 1 0 2 2 2 2 C2 domain KLRAQ PF10205.9 EAZ51281.1 - 0.0014 18.8 0.8 0.0014 18.8 0.8 2.1 1 1 1 2 2 2 1 Predicted coiled-coil domain-containing protein Baculo_E25 PF05274.11 EAZ51281.1 - 0.0043 16.9 0.9 0.013 15.3 0.1 1.9 2 0 0 2 2 2 1 Occlusion-derived virus envelope protein E25 Prefoldin PF02996.17 EAZ51282.1 - 5.4e-21 74.7 0.2 8.4e-21 74.1 0.1 1.3 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EAZ51282.1 - 0.0017 18.2 0.1 0.21 11.6 0.0 2.3 2 0 0 2 2 2 2 Prefoldin subunit WD40 PF00400.32 EAZ51283.1 - 2.6e-25 88.2 17.1 9.3e-05 23.1 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat PRP4 PF08799.11 EAZ51283.1 - 3.3e-13 48.9 1.0 5.3e-13 48.3 1.0 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EAZ51283.1 - 4.6e-06 26.8 1.7 0.11 12.9 0.0 4.5 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EAZ51283.1 - 2.9e-05 22.9 3.3 0.11 11.1 0.1 4.1 3 2 1 5 5 5 2 Nucleoporin Nup120/160 Topoisom_bac PF01131.20 EAZ51284.1 - 2.8e-93 313.2 0.0 5.8e-93 312.1 0.0 1.4 1 1 1 2 2 2 1 DNA topoisomerase Toprim PF01751.22 EAZ51284.1 - 5.1e-12 45.9 0.0 1.8e-11 44.2 0.0 2.0 1 0 0 1 1 1 1 Toprim domain Transpos_assoc PF13963.6 EAZ51284.1 - 0.063 13.6 0.1 0.38 11.1 0.0 2.4 1 1 1 2 2 2 0 Transposase-associated domain Actin PF00022.19 EAZ51285.1 - 2.8e-47 161.2 0.0 2.3e-25 89.0 0.0 2.0 1 1 1 2 2 2 2 Actin Steroid_dh PF02544.16 EAZ51286.1 - 4.7e-17 62.4 13.1 4.7e-17 62.4 13.1 2.2 2 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EAZ51286.1 - 0.0037 16.8 3.3 0.0059 16.1 3.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Ribosomal_L3 PF00297.22 EAZ51287.1 - 1.3e-120 402.8 0.6 1.5e-120 402.6 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 MORN PF02493.20 EAZ51288.1 - 1.1e-60 198.0 75.6 3.9e-09 35.9 3.0 12.4 13 1 0 13 13 13 11 MORN repeat DJ-1_PfpI PF01965.24 EAZ51289.1 - 7.9e-34 116.8 0.1 9.1e-34 116.6 0.1 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EAZ51289.1 - 0.01 15.5 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain ThiJ_like PF17124.5 EAZ51289.1 - 0.15 11.8 0.0 1.2 8.8 0.0 2.0 1 1 1 2 2 2 0 ThiJ/PfpI family-like Proteasome PF00227.26 EAZ51290.1 - 1.6e-54 184.3 0.2 2.2e-54 183.8 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EAZ51290.1 - 4e-13 48.8 0.0 6.8e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ATP-sulfurylase PF01747.17 EAZ51290.1 - 0.085 12.3 0.0 1 8.8 0.0 1.9 1 1 0 2 2 2 0 ATP-sulfurylase ATP_bind_1 PF03029.17 EAZ51291.1 - 2e-69 234.1 0.1 2.5e-69 233.7 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EAZ51291.1 - 0.00052 19.6 0.0 0.0014 18.2 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_31 PF13614.6 EAZ51291.1 - 0.0042 17.0 0.0 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain Dor1 PF04124.12 EAZ51291.1 - 0.039 12.7 0.1 0.051 12.3 0.1 1.2 1 0 0 1 1 1 0 Dor1-like family CbiA PF01656.23 EAZ51291.1 - 0.048 13.7 0.0 0.075 13.1 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain CLP1_P PF16575.5 EAZ51291.1 - 0.08 12.7 0.0 0.32 10.8 0.0 2.0 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ArsA_ATPase PF02374.15 EAZ51291.1 - 0.088 12.0 0.2 2.1 7.4 0.0 2.7 3 0 0 3 3 3 0 Anion-transporting ATPase DUF463 PF04317.12 EAZ51291.1 - 0.11 11.5 0.4 0.9 8.4 0.0 2.0 2 0 0 2 2 2 0 YcjX-like family, DUF463 MeaB PF03308.16 EAZ51291.1 - 0.21 10.5 0.0 0.55 9.2 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Peptidase_M60 PF13402.6 EAZ51292.1 - 3.4e-40 138.3 2.4 6.1e-40 137.4 2.4 1.4 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like Myb_DNA-bind_7 PF15963.5 EAZ51292.1 - 0.043 13.7 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Myb DNA-binding like FAST_2 PF08368.12 EAZ51292.1 - 0.17 12.7 0.6 2.4 9.0 0.1 2.8 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 2 Glycos_transf_2 PF00535.26 EAZ51293.1 - 8.6e-37 126.6 0.0 1.1e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EAZ51293.1 - 1.1e-13 51.6 0.0 1.3e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EAZ51293.1 - 4.2e-09 36.3 0.0 5.8e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EAZ51293.1 - 0.0002 20.9 0.0 0.0003 20.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 EAZ51293.1 - 0.018 15.6 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 DNA_methylase PF00145.17 EAZ51294.1 - 4.5e-18 65.7 1.7 6.9e-18 65.1 1.7 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Turandot PF07240.11 EAZ51294.1 - 0.24 11.4 0.8 2.6 8.1 0.1 2.4 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot EF-hand_6 PF13405.6 EAZ51295.1 - 7.3e-07 28.6 0.2 0.0011 18.7 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EAZ51295.1 - 5.6e-05 22.4 0.2 0.0017 17.8 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EAZ51295.1 - 9.5e-05 22.2 0.1 0.44 10.4 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 EAZ51295.1 - 0.0015 18.9 0.3 0.011 16.1 0.3 2.2 1 1 0 1 1 1 1 EF-hand domain pair Sigma70_r1_1 PF03979.14 EAZ51295.1 - 0.0024 17.9 0.4 2.2 8.4 0.1 2.3 2 0 0 2 2 2 2 Sigma-70 factor, region 1.1 EF-hand_9 PF14658.6 EAZ51295.1 - 0.033 14.5 0.0 0.069 13.5 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 EAZ51295.1 - 0.075 12.6 0.2 0.99 9.0 0.1 2.4 2 0 0 2 2 2 0 EF hand Pkinase PF00069.25 EAZ51296.1 - 7.7e-31 107.4 0.1 1.2e-30 106.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51296.1 - 1.3e-11 44.3 0.1 2.2e-11 43.6 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EAZ51296.1 - 5.7e-05 22.6 0.0 8.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EAZ51296.1 - 0.058 13.0 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SNF2_N PF00176.23 EAZ51298.1 - 3.5e-41 141.1 6.9 4.1e-41 140.9 3.7 2.1 1 1 1 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 EAZ51298.1 - 5.5e-12 46.0 0.7 2.9e-11 43.6 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EAZ51298.1 - 0.00054 18.9 0.0 0.001 18.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF1694 PF07997.11 EAZ51298.1 - 0.02 14.9 2.3 0.073 13.2 2.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) Helicase_C PF00271.31 EAZ51298.1 - 0.044 14.1 3.4 0.097 13.0 0.1 2.8 2 0 0 2 2 2 0 Helicase conserved C-terminal domain Helicase_C PF00271.31 EAZ51299.1 - 0.00028 21.2 2.9 0.00028 21.2 2.9 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Sec63 PF02889.16 EAZ51299.1 - 0.00052 19.2 0.9 0.00088 18.5 0.1 1.8 2 0 0 2 2 2 1 Sec63 Brl domain KH_5 PF13184.6 EAZ51299.1 - 0.57 10.3 3.7 23 5.1 0.3 3.3 2 1 0 2 2 2 0 NusA-like KH domain Sec63 PF02889.16 EAZ51300.1 - 1.5e-20 73.4 10.6 2.9e-20 72.5 10.6 1.4 1 1 0 1 1 1 1 Sec63 Brl domain PPO1_KFDV PF12143.8 EAZ51300.1 - 0.042 14.0 0.2 0.1 12.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) Bap31_Bap29_C PF18035.1 EAZ51301.1 - 0.2 11.7 0.1 0.25 11.4 0.1 1.2 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain p25-alpha PF05517.12 EAZ51302.1 - 2.6e-10 40.7 1.6 4.6e-10 39.9 1.6 1.4 1 0 0 1 1 1 1 p25-alpha DCX PF03607.17 EAZ51302.1 - 1.6e-07 31.3 0.0 4.6e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Doublecortin Cullin PF00888.22 EAZ51303.1 - 7.4e-20 71.1 14.5 1.8e-08 33.5 0.3 4.4 4 1 0 4 4 4 3 Cullin family Actin PF00022.19 EAZ51304.1 - 2.7e-143 477.5 0.0 1.1e-142 475.4 0.0 1.7 1 1 0 1 1 1 1 Actin Sod_Fe_C PF02777.18 EAZ51305.1 - 2.1e-36 124.2 0.9 9.5e-36 122.1 0.0 2.1 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EAZ51305.1 - 1.7e-30 105.3 0.1 3.6e-30 104.3 0.1 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain CobN-Mg_chel PF02514.16 EAZ51305.1 - 0.14 9.8 0.0 0.18 9.5 0.0 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase RRM_1 PF00076.22 EAZ51306.1 - 9.5e-27 92.6 1.2 2.9e-12 46.2 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EAZ51306.1 - 1.3e-08 34.9 1.1 0.0052 16.9 0.1 3.1 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EAZ51306.1 - 0.0024 17.8 0.3 0.94 9.5 0.1 2.9 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EAZ51306.1 - 0.03 14.0 0.3 8.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Pro_isomerase PF00160.21 EAZ51307.1 - 8.8e-40 136.6 0.0 1e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M16 PF00675.20 EAZ51308.1 - 1.3e-45 155.0 0.0 2.3e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EAZ51308.1 - 5.5e-14 52.6 0.2 2.2e-12 47.3 0.2 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain DUF725 PF05267.12 EAZ51308.1 - 0.027 14.5 0.2 0.082 12.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF725) LOH1CR12 PF10158.9 EAZ51308.1 - 0.058 13.4 0.0 3.4 7.7 0.1 2.3 2 0 0 2 2 2 0 Tumour suppressor protein GrpE PF01025.19 EAZ51309.1 - 1.7e-47 161.2 3.2 2.1e-47 160.9 3.2 1.1 1 0 0 1 1 1 1 GrpE Pkinase PF00069.25 EAZ51310.1 - 1.5e-60 204.8 0.0 1.7e-60 204.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51310.1 - 2.4e-33 115.5 0.0 2.9e-33 115.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EAZ51310.1 - 3.3e-05 23.6 0.1 0.014 15.0 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EAZ51310.1 - 0.025 13.5 0.2 0.1 11.5 0.1 1.8 1 1 1 2 2 2 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EAZ51310.1 - 0.027 13.5 0.7 0.042 12.8 0.7 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 EAZ51310.1 - 0.033 13.8 1.0 1.5 8.4 0.1 2.3 1 1 1 2 2 2 0 RIO1 family APH PF01636.23 EAZ51310.1 - 0.062 13.2 0.0 0.19 11.6 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EAZ51310.1 - 0.14 10.9 0.2 1.1 8.0 0.1 1.9 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 EAZ51310.1 - 0.18 11.1 0.1 0.39 10.1 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arf PF00025.21 EAZ51311.1 - 1.1e-69 233.4 0.2 1.2e-69 233.2 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EAZ51311.1 - 6.8e-12 45.7 0.0 9.4e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EAZ51311.1 - 3.3e-10 39.7 0.9 3.5e-05 23.1 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EAZ51311.1 - 4.1e-09 36.2 0.0 4.8e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EAZ51311.1 - 1e-07 31.6 0.0 1.3e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EAZ51311.1 - 2.3e-07 30.4 0.0 3.1e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EAZ51311.1 - 5.5e-06 26.4 0.0 8.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EAZ51311.1 - 0.011 15.3 0.0 2.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B TniB PF05621.11 EAZ51311.1 - 0.02 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.27 EAZ51311.1 - 0.078 12.5 0.0 0.49 9.9 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EAZ51311.1 - 0.096 12.3 0.0 0.77 9.3 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain 6PF2K PF01591.18 EAZ51311.1 - 0.18 11.1 0.3 1.9 7.7 0.1 2.0 1 1 1 2 2 2 0 6-phosphofructo-2-kinase DEAD PF00270.29 EAZ51312.1 - 4.7e-43 147.0 0.0 2.5e-42 144.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51312.1 - 1.1e-29 103.0 0.4 7.1e-27 94.0 0.3 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51312.1 - 1.3e-08 35.0 0.0 9.1e-08 32.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EAZ51312.1 - 0.08 13.2 2.5 0.44 10.8 0.6 3.1 2 1 0 2 2 2 0 AAA domain Proteasome PF00227.26 EAZ51313.1 - 5.9e-29 100.9 0.0 7e-29 100.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Peptidase_S24 PF00717.23 EAZ51314.1 - 4.1e-10 39.5 0.1 5.9e-10 39.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Exo5 PF09810.9 EAZ51315.1 - 2.2e-56 191.9 6.6 1e-55 189.8 6.6 1.8 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PIN_4 PF13638.6 EAZ51315.1 - 0.072 13.4 1.8 0.87 9.9 0.0 2.6 3 0 0 3 3 3 0 PIN domain Nop10p PF04135.12 EAZ51316.1 - 3.4e-20 71.8 0.1 3.8e-20 71.7 0.1 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family BNIP3 PF06553.12 EAZ51317.1 - 0.052 13.2 0.0 0.087 12.5 0.0 1.4 1 0 0 1 1 1 0 BNIP3 Dynamin_M PF01031.20 EAZ51318.1 - 1.5e-82 277.0 0.0 1.5e-82 277.0 0.0 2.6 3 1 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 EAZ51318.1 - 5.3e-29 101.4 0.0 5.3e-29 101.4 0.0 2.4 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EAZ51318.1 - 2.8e-24 85.1 1.1 2.8e-24 85.1 1.1 3.5 4 0 0 4 4 4 1 Dynamin GTPase effector domain Matrilin_ccoil PF10393.9 EAZ51318.1 - 0.018 14.9 0.1 1 9.3 0.0 3.6 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin HSBP1 PF06825.12 EAZ51318.1 - 0.09 12.6 5.6 33 4.5 0.0 4.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 Peptidase_M41 PF01434.18 EAZ51318.1 - 0.11 12.4 0.3 0.42 10.4 0.3 2.0 1 0 0 1 1 1 0 Peptidase family M41 Mito_carr PF00153.27 EAZ51319.1 - 7e-43 144.5 0.6 7.1e-17 61.1 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3021 PF11457.8 EAZ51319.1 - 0.1 12.9 3.9 0.24 11.7 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3021) UPF0242 PF06785.11 EAZ51320.1 - 0.00042 20.5 23.0 0.00042 20.5 23.0 3.3 1 1 2 3 3 3 1 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 EAZ51320.1 - 0.014 16.0 33.0 0.045 14.4 1.9 4.5 1 1 1 3 3 3 0 SlyX ATG16 PF08614.11 EAZ51320.1 - 2.1 8.6 59.3 5.5 7.2 26.6 3.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Macoilin PF09726.9 EAZ51320.1 - 5.8 5.4 41.8 9.7 4.6 41.8 1.4 1 0 0 1 1 1 0 Macoilin family TMF_DNA_bd PF12329.8 EAZ51320.1 - 6.2 6.9 69.4 1.1 9.3 22.6 4.5 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding PARM PF17061.5 EAZ51320.1 - 7 6.7 11.3 3.8 7.6 8.7 1.8 1 1 1 2 2 2 0 PARM ABC_tran PF00005.27 EAZ51322.1 - 1.1e-52 178.1 3.9 1.4e-30 106.6 0.5 3.1 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EAZ51322.1 - 4e-15 56.2 38.0 1.4e-07 31.4 16.5 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EAZ51322.1 - 6.7e-09 35.5 7.2 0.004 16.6 0.1 4.0 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EAZ51322.1 - 5.6e-07 29.7 2.3 0.051 13.4 0.2 4.1 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EAZ51322.1 - 6.4e-07 29.4 4.5 0.028 14.3 0.1 3.6 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EAZ51322.1 - 3.4e-06 26.7 1.1 0.0068 16.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SSE PF00437.20 EAZ51322.1 - 4.1e-06 26.1 0.2 0.065 12.3 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.6 EAZ51322.1 - 8.6e-06 26.1 1.2 0.14 12.4 0.1 3.5 3 1 0 3 3 2 2 AAA domain MeaB PF03308.16 EAZ51322.1 - 9.1e-06 24.8 0.0 0.036 13.0 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EAZ51322.1 - 1.7e-05 24.9 1.1 0.082 13.0 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EAZ51322.1 - 1.7e-05 25.2 0.0 0.17 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain cobW PF02492.19 EAZ51322.1 - 3.6e-05 23.4 1.3 0.037 13.6 0.1 2.6 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EAZ51322.1 - 0.0002 21.5 7.5 0.031 14.4 0.3 2.9 3 0 0 3 3 2 2 Helicase HerA, central domain AAA_7 PF12775.7 EAZ51322.1 - 0.00046 19.7 0.2 0.7 9.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 EAZ51322.1 - 0.00077 20.0 2.8 1.4 9.4 0.0 3.5 4 0 0 4 4 3 2 AAA domain NB-ARC PF00931.22 EAZ51322.1 - 0.00085 18.6 2.9 0.58 9.3 0.0 3.2 2 1 0 2 2 2 2 NB-ARC domain AAA PF00004.29 EAZ51322.1 - 0.00092 19.6 0.2 0.67 10.4 0.1 3.7 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EAZ51322.1 - 0.00097 19.6 0.1 23 5.4 0.0 3.6 3 0 0 3 3 3 0 AAA domain MobB PF03205.14 EAZ51322.1 - 0.00099 19.0 1.3 0.11 12.4 0.1 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 EAZ51322.1 - 0.0017 17.9 2.2 0.27 10.8 0.0 3.1 4 0 0 4 4 3 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EAZ51322.1 - 0.0021 17.8 0.4 0.93 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EAZ51322.1 - 0.0083 16.3 0.0 3 8.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EAZ51322.1 - 0.0085 16.0 0.8 3 7.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.12 EAZ51322.1 - 0.011 15.0 0.1 5.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 EAZ51322.1 - 0.012 15.4 0.5 12 5.6 0.0 3.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.6 EAZ51322.1 - 0.015 15.8 19.0 0.042 14.4 0.4 4.0 3 1 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EAZ51322.1 - 0.017 14.9 0.0 4.1 7.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 EAZ51322.1 - 0.019 13.9 0.4 2.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF815 PF05673.13 EAZ51322.1 - 0.021 14.0 0.1 0.14 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TsaE PF02367.17 EAZ51322.1 - 0.024 14.6 0.2 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EAZ51322.1 - 0.026 14.5 0.6 44 4.1 0.1 4.0 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EAZ51322.1 - 0.027 14.9 6.9 26 5.2 0.0 5.0 4 1 1 5 5 4 0 RNA helicase Dynamin_N PF00350.23 EAZ51322.1 - 0.033 14.3 3.9 2.6 8.1 0.1 3.5 3 0 0 3 3 3 0 Dynamin family FtsK_SpoIIIE PF01580.18 EAZ51322.1 - 0.036 13.4 0.1 0.61 9.4 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP-synt_ab PF00006.25 EAZ51322.1 - 0.049 13.3 0.3 8.8 5.9 0.1 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ABC_ATPase PF09818.9 EAZ51322.1 - 0.099 11.4 7.8 0.03 13.1 1.1 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AAA_19 PF13245.6 EAZ51322.1 - 0.13 12.6 1.8 8.4 6.7 0.0 3.4 4 0 0 4 4 3 0 AAA domain DEAD PF00270.29 EAZ51322.1 - 0.2 11.4 1.3 4.2 7.1 0.9 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase Roc PF08477.13 EAZ51322.1 - 0.21 11.8 1.8 48 4.2 0.1 3.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EAZ51322.1 - 0.25 11.4 5.2 17 5.5 0.0 4.2 3 1 0 4 4 4 0 AAA domain NTPase_1 PF03266.15 EAZ51322.1 - 0.49 10.3 12.2 1.4 8.8 0.1 4.2 5 0 0 5 5 4 0 NTPase SPRY PF00622.28 EAZ51323.1 - 5.7e-10 39.4 0.4 0.00034 20.7 0.1 2.7 2 1 0 2 2 2 2 SPRY domain ubiquitin PF00240.23 EAZ51324.1 - 2.8e-07 30.2 0.1 6e-07 29.1 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EAZ51324.1 - 2.5e-05 24.7 0.1 0.00013 22.3 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 EAZ51324.1 - 0.031 14.1 0.3 0.29 11.0 0.3 2.0 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DEAD PF00270.29 EAZ51325.1 - 3.8e-45 153.8 0.2 1.7e-44 151.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51325.1 - 9.9e-32 109.6 0.8 4e-31 107.6 0.2 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51325.1 - 2.7e-05 24.2 0.0 6.1e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EAZ51325.1 - 0.00013 21.8 0.0 0.00027 20.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 EAZ51325.1 - 0.00031 20.2 0.2 0.00074 18.9 0.0 1.6 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 EAZ51325.1 - 0.0017 18.7 0.2 0.042 14.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain Pkinase PF00069.25 EAZ51326.1 - 2.6e-31 109.0 0.1 1.1e-17 64.3 0.1 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51326.1 - 1.1e-15 57.6 0.0 1.3e-11 44.3 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase FTA2 PF13095.6 EAZ51326.1 - 0.00061 19.5 0.1 0.18 11.4 0.0 2.5 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EAZ51326.1 - 0.0017 17.7 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EAZ51326.1 - 0.056 12.2 1.4 0.1 11.4 0.1 1.9 2 0 0 2 2 2 0 Fungal protein kinase PQQ PF01011.21 EAZ51326.1 - 0.071 13.1 2.4 10 6.3 0.1 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat Pox_A14 PF05767.12 EAZ51326.1 - 0.13 12.4 0.1 0.3 11.3 0.1 1.6 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 APH PF01636.23 EAZ51326.1 - 0.18 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ABC_tran PF00005.27 EAZ51327.1 - 1.7e-36 125.8 0.0 7.4e-18 65.4 0.0 2.3 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EAZ51327.1 - 2.5e-14 52.8 2.9 6.2e-14 51.5 2.9 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 EAZ51327.1 - 2.2e-11 44.1 3.8 0.0024 17.7 0.0 4.2 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EAZ51327.1 - 7.6e-11 41.9 4.6 0.0014 18.1 0.1 3.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EAZ51327.1 - 2.3e-07 30.9 0.6 0.012 15.3 0.1 3.1 2 1 0 3 3 3 2 AAA ATPase domain Rad17 PF03215.15 EAZ51327.1 - 3.1e-07 30.5 0.0 0.031 14.2 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain Fer4 PF00037.27 EAZ51327.1 - 2e-06 27.4 3.4 2e-06 27.4 3.4 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_7 PF12838.7 EAZ51327.1 - 3.5e-05 24.3 4.9 0.00018 22.0 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain RsgA_GTPase PF03193.16 EAZ51327.1 - 3.9e-05 23.6 0.1 0.28 11.1 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase Fer4_6 PF12837.7 EAZ51327.1 - 4e-05 23.5 2.9 4e-05 23.5 2.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.6 EAZ51327.1 - 0.00037 20.2 0.3 0.59 9.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EAZ51327.1 - 0.00039 21.0 3.8 0.019 15.5 0.0 3.0 2 1 0 2 2 2 1 AAA domain G-alpha PF00503.20 EAZ51327.1 - 0.00093 18.4 0.0 0.65 9.1 0.3 2.9 1 1 0 2 2 2 1 G-protein alpha subunit RNA_helicase PF00910.22 EAZ51327.1 - 0.0011 19.4 0.1 1.8 9.0 0.0 2.9 3 0 0 3 3 2 1 RNA helicase NACHT PF05729.12 EAZ51327.1 - 0.0011 18.9 0.3 0.37 10.7 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 EAZ51327.1 - 0.0013 19.2 1.7 0.35 11.4 0.0 3.2 4 0 0 4 4 2 1 AAA domain AAA PF00004.29 EAZ51327.1 - 0.0014 19.1 0.2 0.51 10.8 0.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EAZ51327.1 - 0.0015 18.2 0.2 0.21 11.2 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EAZ51327.1 - 0.0021 17.4 0.0 0.025 13.9 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin Fer4_16 PF13484.6 EAZ51327.1 - 0.0033 18.3 4.7 0.0047 17.8 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain SbcCD_C PF13558.6 EAZ51327.1 - 0.0038 17.4 0.0 0.62 10.3 0.0 2.8 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Fer4_9 PF13187.6 EAZ51327.1 - 0.0065 16.6 11.2 0.013 15.6 11.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EAZ51327.1 - 0.0072 16.4 1.8 0.0072 16.4 1.8 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_33 PF13671.6 EAZ51327.1 - 0.0075 16.4 0.0 0.74 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 EAZ51327.1 - 0.008 16.3 1.9 0.008 16.3 1.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_16 PF13191.6 EAZ51327.1 - 0.013 15.9 0.0 8.1 6.8 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EAZ51327.1 - 0.015 15.0 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EAZ51327.1 - 0.018 15.1 0.5 2.1 8.4 0.0 3.1 2 1 1 3 3 3 0 AAA domain VirE PF05272.11 EAZ51327.1 - 0.019 14.7 0.0 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_28 PF13521.6 EAZ51327.1 - 0.021 15.1 0.0 3.2 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EAZ51327.1 - 0.022 13.9 0.5 12 5.0 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain Fer4_21 PF14697.6 EAZ51327.1 - 0.027 14.6 12.8 0.069 13.3 12.8 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_5 PF07728.14 EAZ51327.1 - 0.029 14.4 0.3 14 5.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EAZ51327.1 - 0.038 14.0 0.1 0.8 9.7 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EAZ51327.1 - 0.048 13.9 0.0 6.8 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_8 PF13183.6 EAZ51327.1 - 0.078 13.4 0.2 0.078 13.4 0.2 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain MeaB PF03308.16 EAZ51327.1 - 0.078 11.9 0.4 1.3 7.9 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 EAZ51327.1 - 0.085 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 EAZ51327.1 - 0.09 12.9 0.0 20 5.3 0.0 3.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EAZ51327.1 - 0.12 12.1 0.6 1.6 8.5 0.0 2.8 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Fer4_4 PF12800.7 EAZ51327.1 - 0.36 11.4 16.3 0.55 10.9 3.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain FeoB_N PF02421.18 EAZ51327.1 - 0.91 9.0 3.0 8.7 5.9 0.1 3.5 4 1 1 5 5 5 0 Ferrous iron transport protein B NTPase_1 PF03266.15 EAZ51327.1 - 3.1 7.7 5.1 49 3.8 0.0 3.9 6 0 0 6 6 4 0 NTPase Fer4_17 PF13534.6 EAZ51327.1 - 5.6 7.6 11.6 0.063 13.8 1.5 2.4 1 1 2 3 3 2 0 4Fe-4S dicluster domain Ank_2 PF12796.7 EAZ51328.1 - 4.2e-20 72.1 0.3 1.5e-12 47.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) ACBP PF00887.19 EAZ51328.1 - 1.3e-18 66.9 0.7 2.6e-18 66.0 0.7 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_5 PF13857.6 EAZ51328.1 - 1.9e-17 63.0 0.0 2.2e-10 40.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EAZ51328.1 - 1e-12 47.9 0.1 1.2e-05 25.5 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EAZ51328.1 - 7.6e-11 42.3 0.1 8.8e-08 32.5 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAZ51328.1 - 2.5e-09 36.6 0.0 0.00076 19.8 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Exostosin PF03016.15 EAZ51328.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Exostosin family ERCC4 PF02732.15 EAZ51329.1 - 0.015 15.5 1.0 0.019 15.2 1.0 1.3 1 0 0 1 1 1 0 ERCC4 domain SNF2_N PF00176.23 EAZ51330.1 - 1.2e-52 178.8 1.6 2.5e-52 177.8 1.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EAZ51330.1 - 8.9e-17 61.4 2.7 5.1e-15 55.8 0.1 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51330.1 - 9.4e-12 45.3 0.3 9.4e-12 45.3 0.3 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EAZ51330.1 - 7e-08 32.4 0.1 2.4e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 EAZ51330.1 - 0.00054 19.6 1.4 0.0084 15.7 0.2 3.0 2 0 0 2 2 2 1 DEAD_2 rve_2 PF13333.6 EAZ51330.1 - 0.18 12.0 2.7 3.9 7.7 0.0 3.3 3 0 0 3 3 3 0 Integrase core domain AAA_11 PF13086.6 EAZ51330.1 - 7.9 6.2 20.8 0.75 9.5 4.1 3.4 2 1 0 2 2 2 0 AAA domain Mre11_DNA_bind PF04152.14 EAZ51331.1 - 6.9e-30 104.6 1.3 6.9e-30 104.6 1.3 2.0 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EAZ51331.1 - 5.4e-06 27.1 0.8 1.3e-05 25.8 0.8 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pkinase PF00069.25 EAZ51332.1 - 1.1e-65 221.6 0.1 1.6e-65 221.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51332.1 - 1.3e-45 155.7 0.0 2e-45 155.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EAZ51332.1 - 0.00016 20.6 0.1 0.00048 19.0 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase WD40 PF00400.32 EAZ51333.1 - 7.4e-25 86.7 11.5 0.00052 20.8 0.4 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.11 EAZ51333.1 - 1e-05 25.5 4.9 0.03 14.2 0.1 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EAZ51333.1 - 9.6e-05 22.6 0.9 2.8 8.3 0.0 4.3 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EAZ51333.1 - 0.023 14.0 3.0 0.074 12.4 3.0 2.2 1 1 0 1 1 1 0 WD40-like domain Longin PF13774.6 EAZ51334.1 - 3.8e-21 74.9 0.0 6.9e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EAZ51334.1 - 3.6e-16 58.7 1.2 6.2e-16 58.0 1.2 1.4 1 0 0 1 1 1 1 Synaptobrevin zf-RING_2 PF13639.6 EAZ51335.1 - 7.2e-12 45.5 7.3 1.4e-11 44.5 7.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EAZ51335.1 - 5.9e-08 32.3 5.7 1.5e-07 31.0 5.7 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EAZ51335.1 - 6.5e-08 32.7 6.9 1.2e-07 31.9 6.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EAZ51335.1 - 1.6e-06 27.9 6.9 3e-06 27.0 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAZ51335.1 - 4.1e-06 26.6 6.3 8.7e-06 25.5 6.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAZ51335.1 - 7.5e-06 25.8 5.1 1.6e-05 24.8 5.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EAZ51335.1 - 2e-05 24.5 3.6 4.4e-05 23.4 3.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EAZ51335.1 - 2.1e-05 24.1 6.9 7e-05 22.4 7.0 1.8 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EAZ51335.1 - 8.4e-05 22.4 3.1 0.00014 21.6 3.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EAZ51335.1 - 0.0013 18.7 2.6 0.0027 17.7 2.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 EAZ51335.1 - 0.0082 16.4 2.3 0.0082 16.4 2.3 2.1 1 1 1 2 2 2 1 Zinc-ribbon like family zf-C3H2C3 PF17122.5 EAZ51335.1 - 0.014 15.5 2.8 0.043 13.9 2.8 1.9 1 0 0 1 1 1 0 Zinc-finger CDC48_2 PF02933.17 EAZ51335.1 - 0.045 13.6 0.0 0.27 11.0 0.0 2.3 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 Prok-RING_4 PF14447.6 EAZ51335.1 - 0.052 13.4 8.0 0.063 13.2 6.4 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EAZ51335.1 - 0.054 13.6 4.1 0.13 12.4 3.5 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 FANCL_C PF11793.8 EAZ51335.1 - 0.19 11.9 5.4 0.65 10.2 5.4 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 EAZ51335.1 - 0.22 11.4 5.9 0.56 10.1 5.9 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EAZ51335.1 - 0.24 11.8 6.3 0.62 10.4 6.3 1.8 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EAZ51335.1 - 1.2 9.3 9.2 0.71 10.0 7.0 1.8 2 0 0 2 2 1 0 RING-variant domain Prok-RING_1 PF14446.6 EAZ51335.1 - 1.8 8.6 8.1 0.26 11.2 2.1 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 EAZ51335.1 - 2.4 8.4 8.6 5.5 7.2 7.5 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Thg1 PF04446.12 EAZ51336.1 - 1.2e-48 164.3 0.2 2e-48 163.5 0.2 1.4 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EAZ51336.1 - 1.3e-37 128.6 1.5 2.2e-37 127.9 1.5 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain Ras PF00071.22 EAZ51337.1 - 1.2e-61 207.0 0.2 1.4e-61 206.8 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51337.1 - 3.7e-33 114.3 0.0 6.4e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51337.1 - 1.2e-13 50.9 0.1 1.6e-13 50.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51337.1 - 2.3e-06 27.7 0.1 4.4e-06 26.8 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EAZ51337.1 - 0.00091 18.8 0.1 0.0052 16.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EAZ51337.1 - 0.0044 16.9 0.0 0.44 10.4 0.1 2.2 2 1 0 2 2 2 1 RsgA GTPase DNA_pol_E_B PF04042.16 EAZ51337.1 - 0.0047 16.3 0.0 0.0063 15.9 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B ATPase_2 PF01637.18 EAZ51337.1 - 0.038 13.9 0.1 0.22 11.4 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Gtr1_RagA PF04670.12 EAZ51337.1 - 0.076 12.4 0.0 0.1 11.9 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 EAZ51337.1 - 0.094 12.7 0.1 0.31 11.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain SLS PF14611.6 EAZ51337.1 - 0.095 12.5 0.2 0.21 11.4 0.1 1.6 1 1 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator AAA_22 PF13401.6 EAZ51337.1 - 0.1 12.9 0.0 4.9 7.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain Alg6_Alg8 PF03155.15 EAZ51338.1 - 5.2e-37 128.0 37.9 6.2e-37 127.7 37.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family WD40 PF00400.32 EAZ51339.1 - 1.2e-26 92.4 24.6 4.2e-08 33.7 0.7 7.6 6 1 2 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51339.1 - 5e-13 49.2 0.6 0.087 13.1 0.0 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Asp PF00026.23 EAZ51340.1 - 4.9e-16 59.0 1.0 1.3e-15 57.6 1.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EAZ51340.1 - 9e-13 48.8 0.7 4.1e-11 43.4 0.5 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EAZ51340.1 - 6.5e-12 45.5 0.0 9.8e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal DnaJ PF00226.31 EAZ51341.1 - 2.1e-15 56.6 0.0 5.6e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain La PF05383.17 EAZ51342.1 - 6e-17 61.4 0.8 1.6e-16 60.1 0.8 1.8 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EAZ51342.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos PF00149.28 EAZ51343.1 - 3.7e-36 125.5 0.7 5.2e-36 125.1 0.2 1.5 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EAZ51343.1 - 0.00046 20.6 0.6 0.0011 19.4 0.6 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain BpuJI_N PF11564.8 EAZ51343.1 - 0.13 11.4 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal PTPA PF03095.15 EAZ51344.1 - 3.1e-103 345.4 0.4 3.5e-103 345.2 0.4 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Actin PF00022.19 EAZ51345.1 - 1e-56 192.3 0.0 1.2e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EAZ51345.1 - 0.00016 20.6 0.9 0.068 12.0 0.2 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EAZ51345.1 - 0.037 14.5 1.4 0.32 11.4 0.1 2.6 2 0 0 2 2 2 0 Cell division protein FtsA Proteasome PF00227.26 EAZ51346.1 - 5.3e-36 123.9 0.2 6.5e-36 123.6 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit HA2 PF04408.23 EAZ51347.1 - 1.4e-22 80.0 0.2 6.1e-22 77.9 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EAZ51347.1 - 2.7e-18 66.1 0.1 9.1e-18 64.4 0.0 1.9 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EAZ51347.1 - 2.1e-12 47.4 0.0 8.3e-12 45.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EAZ51347.1 - 5.3e-05 23.5 0.2 0.00033 20.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EAZ51347.1 - 0.00086 18.4 0.0 0.0017 17.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.29 EAZ51347.1 - 0.00088 19.1 0.0 0.0032 17.3 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EAZ51347.1 - 0.0017 18.7 0.0 0.0037 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EAZ51347.1 - 0.0031 17.3 0.0 0.0063 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Glug PF07581.12 EAZ51347.1 - 0.068 13.6 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 The GLUG motif Flavi_DEAD PF07652.14 EAZ51347.1 - 0.14 12.1 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_23 PF13476.6 EAZ51347.1 - 0.41 11.1 0.1 0.41 11.1 0.1 4.0 2 1 1 3 3 2 0 AAA domain Ank_2 PF12796.7 EAZ51348.1 - 6.9e-23 81.0 3.1 8.1e-07 29.5 0.1 3.8 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAZ51348.1 - 8.2e-17 61.3 0.5 0.00033 21.1 0.0 5.1 2 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EAZ51348.1 - 1.8e-12 46.3 0.5 0.014 15.9 0.0 6.6 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EAZ51348.1 - 1.2e-10 41.4 0.1 0.036 14.5 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EAZ51348.1 - 5.2e-06 26.6 0.5 0.094 13.1 0.0 4.9 3 2 3 6 6 6 2 Ankyrin repeats (many copies) TPR_1 PF00515.28 EAZ51348.1 - 6.3e-05 22.6 0.0 0.021 14.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EAZ51348.1 - 0.00014 21.7 0.0 0.44 10.8 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EAZ51348.1 - 0.01 16.0 1.0 5 7.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EAZ51348.1 - 0.026 14.2 0.1 0.13 12.0 0.0 2.2 3 0 0 3 3 3 0 TPR repeat LSM PF01423.22 EAZ51349.1 - 5.7e-18 64.4 0.1 8.3e-18 63.9 0.1 1.3 1 0 0 1 1 1 1 LSM domain Ufm1 PF03671.14 EAZ51350.1 - 8.6e-16 57.8 0.1 1.2e-15 57.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Pkinase PF00069.25 EAZ51351.1 - 4.1e-46 157.5 0.0 8.7e-46 156.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51351.1 - 1.9e-30 106.0 0.0 4.8e-30 104.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51351.1 - 3.5e-07 29.8 0.0 6.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EAZ51351.1 - 0.024 14.2 0.6 0.88 9.1 0.1 2.5 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 EAZ51351.1 - 0.098 12.6 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EAZ51351.1 - 1.5 7.5 5.4 0.42 9.3 0.1 2.3 2 0 0 2 2 2 0 Fungal protein kinase Ubie_methyltran PF01209.18 EAZ51352.1 - 2.2e-58 197.3 0.1 3e-58 196.9 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EAZ51352.1 - 2.3e-13 50.6 0.0 3.8e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAZ51352.1 - 1.5e-11 44.8 0.0 2.5e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAZ51352.1 - 5.9e-10 39.8 0.0 1.4e-09 38.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAZ51352.1 - 6.6e-08 32.5 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAZ51352.1 - 1.8e-07 31.1 0.0 5.3e-07 29.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain GSH-S_ATP PF02955.16 EAZ51352.1 - 0.039 13.4 0.2 0.067 12.6 0.2 1.4 1 1 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain FlgD_ig PF13860.6 EAZ51352.1 - 0.073 13.0 0.1 0.19 11.6 0.0 1.7 1 1 1 2 2 2 0 FlgD Ig-like domain DREV PF05219.12 EAZ51352.1 - 0.09 11.9 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_8 PF05148.15 EAZ51352.1 - 0.09 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Hypothetical methyltransferase LSM PF01423.22 EAZ51353.1 - 1.2e-21 76.2 0.8 1.5e-21 75.8 0.8 1.1 1 0 0 1 1 1 1 LSM domain XAP5 PF04921.14 EAZ51355.1 - 4.8e-24 85.6 7.0 6.5e-24 85.1 7.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator ALS2CR11 PF15729.5 EAZ51355.1 - 0.19 10.9 7.2 0.24 10.5 7.2 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 DUF4207 PF13904.6 EAZ51355.1 - 0.19 11.4 6.4 0.48 10.1 6.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4207) NUC153 PF08159.12 EAZ51356.1 - 0.032 14.0 4.6 0.087 12.7 4.6 1.8 1 0 0 1 1 1 0 NUC153 domain Methyltransf_12 PF08242.12 EAZ51356.1 - 0.14 12.9 5.3 0.18 12.5 0.1 3.3 4 0 0 4 4 4 0 Methyltransferase domain Abhydrolase_2 PF02230.16 EAZ51357.1 - 3.3e-31 108.8 1.4 2.3e-30 106.0 1.4 2.2 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EAZ51357.1 - 5.2e-05 23.0 0.0 0.00017 21.3 0.0 1.9 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EAZ51357.1 - 0.021 14.7 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold SR-25 PF10500.9 EAZ51358.1 - 0.25 10.9 0.0 0.25 10.9 0.0 3.2 2 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein FHA PF00498.26 EAZ51359.1 - 6.4e-15 55.3 1.1 3.5e-14 52.9 0.3 2.2 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EAZ51359.1 - 1.2e-06 28.7 0.0 3.1e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Asp PF00026.23 EAZ51360.1 - 1.5e-20 73.9 6.9 8.2e-13 48.4 0.7 3.4 2 2 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EAZ51360.1 - 1.6e-17 64.3 2.0 1.6e-17 64.3 2.0 3.2 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EAZ51360.1 - 1.5e-12 47.6 3.4 2.7e-06 27.3 0.0 3.1 4 0 0 4 4 4 2 Xylanase inhibitor C-terminal dUTPase PF00692.19 EAZ51361.1 - 3.9e-09 36.3 0.0 4.1e-08 33.0 0.0 2.0 2 0 0 2 2 2 1 dUTPase SpoU_methylase PF00588.19 EAZ51362.1 - 2.2e-27 96.0 0.0 2.9e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family BET PF17035.5 EAZ51362.1 - 0.47 10.7 2.4 5.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation TolA_bind_tri PF16331.5 EAZ51363.1 - 0.0067 16.5 0.5 0.0067 16.5 0.5 17.0 11 4 5 17 17 17 4 TolA binding protein trimerisation PRIMA1 PF16101.5 EAZ51363.1 - 2.4 8.2 11.8 6.6 6.8 11.8 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Dynein_light PF01221.18 EAZ51364.1 - 7.3e-42 141.6 1.0 8.1e-42 141.5 1.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 EF-hand_1 PF00036.32 EAZ51365.1 - 1.2e-38 127.8 11.5 3.6e-09 35.5 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAZ51365.1 - 6.8e-33 112.9 3.3 1.7e-16 60.4 1.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EAZ51365.1 - 1e-28 96.8 6.9 2.9e-09 36.1 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EAZ51365.1 - 4.5e-28 96.9 12.8 5e-14 51.9 1.2 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EAZ51365.1 - 4.7e-24 82.8 9.4 3.8e-06 26.1 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EAZ51365.1 - 5.2e-13 49.1 0.1 3.7e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EAZ51365.1 - 4.9e-08 32.9 0.5 0.0019 18.2 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EAZ51365.1 - 2.3e-07 31.1 0.2 0.0093 16.3 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EAZ51365.1 - 7.2e-05 22.7 0.0 0.35 10.9 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 EAZ51365.1 - 0.0001 23.1 0.0 0.01 16.7 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 EAZ51365.1 - 0.0019 18.4 4.3 0.13 12.5 0.3 3.1 1 1 3 4 4 4 1 Dockerin type I domain DUF3349 PF11829.8 EAZ51365.1 - 0.0019 18.9 0.2 2.6 8.9 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) EFhand_Ca_insen PF08726.10 EAZ51365.1 - 0.0024 17.9 0.5 0.0078 16.3 0.1 2.1 2 2 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.13 EAZ51365.1 - 0.0032 17.4 0.2 1.1 9.2 0.0 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EAZ51365.1 - 0.0032 17.4 0.2 0.68 9.8 0.0 3.0 1 1 2 3 3 3 1 Caleosin related protein MotA_activ PF09114.10 EAZ51365.1 - 0.0068 16.5 0.0 0.089 12.9 0.0 2.1 2 0 0 2 2 2 1 Transcription factor MotA, activation domain YqeY PF09424.10 EAZ51365.1 - 0.015 15.3 0.1 0.31 11.1 0.0 2.1 1 1 1 2 2 2 0 Yqey-like protein RNA_pol_Rpb4 PF03874.16 EAZ51365.1 - 0.05 13.9 0.9 1.4 9.2 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 DUF1811 PF08838.10 EAZ51365.1 - 0.085 13.1 0.0 20 5.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) SapB_1 PF05184.15 EAZ51365.1 - 0.089 12.8 3.3 4.5 7.4 0.0 3.2 4 0 0 4 4 4 0 Saposin-like type B, region 1 SUB1_ProdP9 PF18213.1 EAZ51365.1 - 0.26 11.1 2.4 4.4 7.2 0.1 2.9 1 1 2 3 3 3 0 SUB1 protease Prodomain ProdP9 zf-C3HC4_2 PF13923.6 EAZ51366.1 - 3.8e-11 42.6 11.1 7.6e-11 41.7 11.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EAZ51366.1 - 3.6e-09 36.3 11.8 9.4e-09 35.0 11.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAZ51366.1 - 8.5e-09 35.1 11.9 1.7e-08 34.2 11.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EAZ51366.1 - 6.3e-08 32.4 11.2 1.3e-07 31.3 11.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EAZ51366.1 - 7e-07 29.5 12.9 1.5e-06 28.4 12.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EAZ51366.1 - 1.5e-06 28.2 8.4 3.3e-06 27.0 8.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EAZ51366.1 - 1.5e-05 24.9 12.8 3e-05 23.9 12.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EAZ51366.1 - 0.00037 20.7 7.4 0.0014 18.9 7.4 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EAZ51366.1 - 0.0031 17.4 6.2 0.0063 16.4 6.2 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EAZ51366.1 - 0.0041 17.3 9.5 0.011 15.8 9.5 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING DUF4200 PF13863.6 EAZ51366.1 - 0.0081 16.6 0.4 0.0081 16.6 0.4 6.2 4 2 0 4 4 4 1 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.8 EAZ51366.1 - 0.014 15.3 13.4 0.014 15.3 13.4 8.0 5 2 0 6 6 6 0 TATA element modulatory factor 1 DNA binding zf-UDP PF14569.6 EAZ51366.1 - 0.023 14.8 5.4 0.075 13.2 5.4 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger Prp19 PF08606.11 EAZ51366.1 - 0.039 13.9 5.1 0.34 10.9 0.0 3.8 4 0 0 4 4 4 0 Prp19/Pso4-like zf-ANAPC11 PF12861.7 EAZ51366.1 - 0.82 9.8 4.7 1.6 8.8 4.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger HSBP1 PF06825.12 EAZ51366.1 - 3.3 7.6 8.9 19 5.2 0.9 4.2 4 0 0 4 4 4 0 Heat shock factor binding protein 1 Pkinase PF00069.25 EAZ51367.1 - 1.5e-20 73.7 0.0 2.6e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EAZ51367.1 - 0.034 12.9 0.4 0.057 12.2 0.4 1.3 1 0 0 1 1 1 0 Fungal protein kinase DEAD PF00270.29 EAZ51368.1 - 3e-48 163.9 0.0 6.7e-48 162.8 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51368.1 - 3.3e-30 104.7 0.0 1.4e-29 102.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51368.1 - 0.0011 19.0 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EAZ51368.1 - 0.0062 15.8 0.0 0.0097 15.1 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ArfGap PF01412.18 EAZ51368.1 - 0.074 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf CMS1 PF14617.6 EAZ51368.1 - 0.12 11.6 0.0 0.37 10.1 0.0 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Mito_carr PF00153.27 EAZ51369.1 - 6.7e-61 202.2 1.6 9.2e-20 70.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cyt-b5 PF00173.28 EAZ51370.1 - 1.1e-13 51.1 0.1 2.1e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PLDc_2 PF13091.6 EAZ51371.1 - 8.2e-08 32.2 1.3 0.011 15.6 0.1 2.8 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EAZ51371.1 - 0.0039 17.3 2.0 0.012 15.8 0.1 2.5 2 0 0 2 2 2 1 Phospholipase D Active site motif zf-C2H2 PF00096.26 EAZ51372.1 - 2.9e-26 90.4 49.9 1.1e-05 25.6 4.0 7.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EAZ51372.1 - 1.8e-22 78.1 48.7 0.00054 20.6 1.1 7.6 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EAZ51372.1 - 1.3e-10 41.2 54.0 1.4e-05 25.3 2.5 8.8 9 1 0 9 9 9 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 EAZ51372.1 - 5.5e-08 32.6 30.7 0.002 18.1 0.1 6.5 6 1 0 6 6 6 3 C2H2-type zinc finger FOXP-CC PF16159.5 EAZ51372.1 - 2e-05 25.1 13.5 1.3 9.7 0.1 6.4 4 2 3 7 7 7 2 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EAZ51372.1 - 2.2e-05 24.1 38.1 0.078 12.8 1.0 6.8 6 1 0 6 6 6 4 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 EAZ51372.1 - 0.0045 17.7 16.0 0.042 14.5 6.7 3.9 2 1 1 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 EAZ51372.1 - 0.0052 16.4 1.9 6 6.6 0.0 3.9 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf-C2H2_aberr PF17017.5 EAZ51372.1 - 0.009 16.2 19.8 0.67 10.1 4.9 3.8 3 1 1 4 4 4 2 Aberrant zinc-finger Ribosomal_S26e PF01283.19 EAZ51372.1 - 0.015 15.7 0.3 2.5 8.6 0.2 2.5 1 1 1 2 2 2 0 Ribosomal protein S26e PBECR3 PF18812.1 EAZ51372.1 - 0.018 15.0 1.0 9.2 6.3 0.0 3.8 4 1 0 4 4 4 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 zf-met PF12874.7 EAZ51372.1 - 0.018 15.4 28.6 0.27 11.7 0.1 7.4 8 0 0 8 8 7 0 Zinc-finger of C2H2 type zf-MYST PF17772.1 EAZ51372.1 - 0.28 10.8 0.0 0.28 10.8 0.0 5.7 4 3 1 5 5 5 0 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 EAZ51372.1 - 0.29 11.5 25.2 3.2 8.2 0.4 8.0 8 1 1 9 9 9 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EAZ51372.1 - 1.9 8.2 20.3 2.3 7.9 0.9 4.9 1 1 4 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF629 PF04780.12 EAZ51372.1 - 4.7 5.6 22.1 2.9 6.3 1.5 4.8 2 1 3 5 5 5 0 Protein of unknown function (DUF629) ATP-synt_ab PF00006.25 EAZ51373.1 - 7.8e-58 195.6 0.0 1.9e-57 194.3 0.0 1.7 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EAZ51373.1 - 3.1e-22 78.9 0.4 7e-22 77.7 0.4 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 EAZ51373.1 - 0.0044 16.4 2.2 0.0044 16.4 0.8 1.7 2 0 0 2 2 2 1 KaiC ATPase_2 PF01637.18 EAZ51373.1 - 0.019 14.9 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EAZ51373.1 - 0.029 13.5 0.1 0.058 12.6 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EAZ51373.1 - 0.034 14.6 0.1 0.081 13.3 0.1 1.7 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 EAZ51373.1 - 0.064 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EAZ51373.1 - 0.093 13.1 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Pox_A32 PF04665.12 EAZ51373.1 - 0.19 11.2 0.5 0.6 9.5 0.3 1.8 2 0 0 2 2 2 0 Poxvirus A32 protein ABC_tran PF00005.27 EAZ51373.1 - 1.3 9.5 4.2 1.8 9.1 0.3 2.9 3 1 1 4 4 4 0 ABC transporter ThiF PF00899.21 EAZ51374.1 - 2.5e-62 210.4 0.1 3.7e-62 209.9 0.1 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EAZ51374.1 - 2.2e-14 53.8 0.0 1.3e-13 51.4 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EAZ51374.1 - 9.3e-07 29.0 7.5 2.4e-06 27.7 1.7 2.6 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EAZ51374.1 - 0.0017 18.8 0.4 0.0083 16.6 0.0 2.2 2 1 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EAZ51374.1 - 0.0049 16.9 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EAZ51374.1 - 0.0061 16.8 3.8 0.022 15.0 1.8 2.5 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Pyr_redox PF00070.27 EAZ51374.1 - 0.066 13.8 0.1 0.2 12.3 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 EAZ51375.1 - 4.3e-47 160.7 0.0 4.3e-46 157.4 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51375.1 - 2.2e-18 66.5 0.0 1.3e-10 41.0 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EAZ51375.1 - 0.00015 20.7 0.0 0.00026 19.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EAZ51375.1 - 0.00053 19.4 0.1 0.017 14.5 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family dCMP_cyt_deam_1 PF00383.23 EAZ51376.1 - 6.2e-13 48.5 2.3 1.4e-12 47.4 2.3 1.6 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EAZ51376.1 - 7.1e-12 45.3 2.3 1e-05 25.3 0.1 2.1 2 0 0 2 2 2 2 MafB19-like deaminase Yuri_gagarin PF15934.5 EAZ51376.1 - 0.041 13.7 0.3 0.06 13.2 0.3 1.2 1 0 0 1 1 1 0 Yuri gagarin Bd3614-deam PF14439.6 EAZ51376.1 - 0.093 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase Pro_isomerase PF00160.21 EAZ51377.1 - 1.4e-44 152.1 0.0 1.6e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DnaJ_C PF01556.18 EAZ51378.1 - 2.6e-41 141.1 0.4 3.6e-41 140.7 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EAZ51378.1 - 3.2e-26 91.2 3.3 5.4e-26 90.5 3.3 1.4 1 0 0 1 1 1 1 DnaJ domain DUF2784 PF10861.8 EAZ51378.1 - 0.25 11.4 0.0 0.46 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) Inositol_P PF00459.25 EAZ51379.1 - 1.1e-38 133.3 0.0 1.4e-38 132.9 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 EAZ51379.1 - 0.00095 18.7 0.0 0.0024 17.4 0.0 1.6 1 1 1 2 2 2 1 Fructose-1-6-bisphosphatase, N-terminal domain zf-C3HC4 PF00097.25 EAZ51380.1 - 2.2e-09 37.0 9.4 3.4e-09 36.4 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EAZ51380.1 - 9.9e-09 34.9 6.8 1.4e-08 34.4 6.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EAZ51380.1 - 1.2e-08 34.6 9.0 1.8e-08 34.1 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EAZ51380.1 - 1.3e-07 31.4 8.7 2e-07 30.8 8.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EAZ51380.1 - 3.2e-07 30.6 11.4 4.7e-07 30.0 11.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EAZ51380.1 - 6.8e-07 29.2 7.2 1.5e-05 24.9 8.3 2.2 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EAZ51380.1 - 3.3e-06 26.9 7.3 5.1e-06 26.3 7.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EAZ51380.1 - 0.00027 21.0 9.8 0.00058 20.0 9.8 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EAZ51380.1 - 0.00029 21.0 7.6 0.00056 20.2 7.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain Rtf2 PF04641.12 EAZ51380.1 - 0.0042 16.5 0.8 0.015 14.7 0.8 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger zf-RING_6 PF14835.6 EAZ51380.1 - 0.55 10.1 6.1 1 9.3 6.1 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Baculo_IE-1 PF05290.11 EAZ51380.1 - 2.2 8.2 8.9 4.1 7.4 8.9 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Pkinase PF00069.25 EAZ51381.1 - 6.7e-53 179.7 0.4 3.6e-30 105.2 0.5 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51381.1 - 6.2e-24 84.7 0.1 1.1e-15 57.6 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EAZ51381.1 - 6.1e-08 32.9 0.1 0.00017 21.6 0.2 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EAZ51381.1 - 3e-06 26.8 0.3 0.0009 18.6 0.1 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EAZ51381.1 - 0.00057 19.3 0.1 0.0011 18.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EAZ51381.1 - 0.0019 17.2 0.3 0.0029 16.6 0.3 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EAZ51381.1 - 0.045 12.5 0.1 0.067 12.0 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase TPR_1 PF00515.28 EAZ51382.1 - 5.7e-44 146.2 28.1 2.2e-09 36.7 1.0 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EAZ51382.1 - 1.4e-36 121.7 22.1 1.3e-06 28.1 0.2 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 EAZ51382.1 - 1.8e-23 81.9 10.9 1.7e-10 40.4 0.1 4.8 4 1 1 5 5 5 4 TPR repeat TPR_8 PF13181.6 EAZ51382.1 - 2.2e-19 68.0 25.3 7.2e-05 22.7 1.5 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.6 EAZ51382.1 - 3.3e-19 69.0 2.2 1.4e-08 34.9 0.0 5.0 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 EAZ51382.1 - 3.2e-17 61.6 12.1 0.00054 20.2 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 EAZ51382.1 - 2.5e-16 59.9 4.4 0.0018 18.8 0.3 4.6 2 2 2 4 4 4 4 Tetratricopeptide repeat STI1 PF17830.1 EAZ51382.1 - 1.3e-15 57.1 2.7 1.5e-15 56.8 0.6 2.4 2 0 0 2 2 1 1 STI1 domain TPR_16 PF13432.6 EAZ51382.1 - 1.2e-14 54.6 0.0 8.5e-08 32.7 0.0 4.1 4 2 1 5 5 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EAZ51382.1 - 6.8e-11 42.0 0.8 3.2 8.8 0.0 6.9 3 3 4 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EAZ51382.1 - 2.6e-10 39.8 5.9 0.72 9.8 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EAZ51382.1 - 6.9e-10 38.9 0.0 0.0043 17.2 0.1 4.0 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EAZ51382.1 - 1.3e-05 24.9 8.5 0.0037 17.2 0.1 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAZ51382.1 - 1.7e-05 25.0 10.3 0.042 14.1 1.0 3.5 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EAZ51382.1 - 8.3e-05 23.0 11.7 0.34 11.6 0.2 6.2 5 1 1 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EAZ51382.1 - 0.00014 21.8 17.5 0.2 11.7 0.3 6.2 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 EAZ51382.1 - 0.00076 18.8 0.5 3.4 6.8 0.0 3.4 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 EAZ51382.1 - 0.0028 17.4 10.1 0.065 12.9 4.3 4.0 1 1 1 3 3 3 1 Tetratricopeptide repeat-like domain XPC-binding PF09280.11 EAZ51382.1 - 0.0097 15.6 1.6 0.025 14.3 1.6 1.7 1 0 0 1 1 1 1 XPC-binding domain IFNGR1 PF07140.11 EAZ51382.1 - 0.038 14.1 0.7 0.082 13.0 0.7 1.6 1 0 0 1 1 1 0 Interferon gamma receptor (IFNGR1) TPR_3 PF07720.12 EAZ51382.1 - 0.041 13.9 0.1 0.041 13.9 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EAZ51382.1 - 0.048 13.6 8.8 0.32 11.0 0.5 3.5 3 2 0 3 3 3 0 Mad3/BUB1 homology region 1 PPR PF01535.20 EAZ51382.1 - 0.12 12.7 0.4 0.12 12.7 0.4 3.0 3 0 0 3 3 2 0 PPR repeat Coatomer_E PF04733.14 EAZ51382.1 - 0.12 11.7 10.1 6.1 6.2 0.0 4.2 1 1 3 4 4 4 0 Coatomer epsilon subunit Syntaxin-6_N PF09177.11 EAZ51382.1 - 0.32 11.6 2.6 0.48 11.0 0.7 2.2 2 1 0 2 2 2 0 Syntaxin 6, N-terminal SNAP PF14938.6 EAZ51382.1 - 0.33 10.3 15.3 0.13 11.7 9.7 2.4 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP MIT PF04212.18 EAZ51382.1 - 0.78 9.8 17.0 12 6.1 0.1 5.7 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain Seryl_tRNA_N PF02403.22 EAZ51382.1 - 1.3 9.3 7.5 0.36 11.1 2.8 2.4 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain WD40 PF00400.32 EAZ51383.1 - 5.4e-49 163.1 32.1 3.7e-09 37.1 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51383.1 - 1e-10 41.8 2.3 0.063 13.6 0.1 4.7 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EAZ51383.1 - 9e-06 25.2 0.0 0.18 11.1 0.0 3.1 2 2 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 EAZ51383.1 - 0.00015 20.8 0.2 2.2 7.1 0.1 3.9 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EAZ51383.1 - 0.0033 17.9 1.0 2.2 8.9 0.0 3.9 3 1 0 3 3 3 1 PQQ-like domain VID27 PF08553.10 EAZ51383.1 - 0.032 13.3 0.0 0.084 11.9 0.0 1.8 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain PALB2_WD40 PF16756.5 EAZ51383.1 - 0.046 12.6 1.6 1.5 7.7 0.0 3.1 3 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 EAZ51383.1 - 0.17 11.9 0.1 9.1 6.4 0.1 3.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Pkinase PF00069.25 EAZ51384.1 - 6.1e-12 45.4 0.0 6.7e-12 45.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51384.1 - 1e-06 28.3 0.0 1.1e-06 28.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EAZ51384.1 - 0.0023 17.3 0.0 0.0025 17.2 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EAZ51384.1 - 0.0097 15.3 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.11 EAZ51384.1 - 0.047 12.7 0.0 0.05 12.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EAZ51384.1 - 0.071 13.0 0.0 0.082 12.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EAZ51384.1 - 0.078 11.7 0.0 0.079 11.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Spc7 PF08317.11 EAZ51385.1 - 0.00048 19.1 16.1 0.00048 19.1 16.1 1.6 1 1 0 1 1 1 1 Spc7 kinetochore protein SLATT_1 PF18181.1 EAZ51385.1 - 0.1 12.6 0.5 0.21 11.5 0.5 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 COG2 PF06148.11 EAZ51385.1 - 0.32 11.1 10.9 0.028 14.5 2.6 2.6 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CC2-LZ PF16516.5 EAZ51385.1 - 0.33 11.3 12.3 0.84 10.0 4.6 2.9 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Fib_alpha PF08702.10 EAZ51385.1 - 1.2 9.4 18.8 0.048 13.8 10.7 2.5 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EAZ51385.1 - 1.5 8.9 11.6 0.41 10.7 0.8 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 EAZ51385.1 - 2 8.6 17.5 0.31 11.3 11.8 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Uso1_p115_C PF04871.13 EAZ51385.1 - 5.9 7.3 22.2 0.56 10.6 14.3 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region GDP_Man_Dehyd PF16363.5 EAZ51386.1 - 3.6e-52 177.8 0.0 4.3e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EAZ51386.1 - 1.6e-45 155.5 0.0 2e-45 155.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EAZ51386.1 - 4.3e-10 39.2 0.0 6.2e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EAZ51386.1 - 1.7e-08 33.8 0.0 2.3e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EAZ51386.1 - 1e-05 24.8 0.0 1.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EAZ51386.1 - 0.0028 16.8 0.1 0.035 13.2 0.1 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EAZ51386.1 - 0.018 14.6 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 EAZ51386.1 - 0.027 14.0 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_10 PF13460.6 EAZ51386.1 - 0.2 11.5 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Ras PF00071.22 EAZ51387.1 - 8.4e-59 197.8 0.4 1.1e-58 197.5 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51387.1 - 9.1e-36 122.7 0.1 1.7e-35 121.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51387.1 - 5.6e-15 55.2 0.3 7.6e-15 54.8 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EAZ51387.1 - 3.3e-06 26.8 0.0 9.7e-06 25.3 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EAZ51387.1 - 0.0002 21.4 0.0 0.00033 20.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EAZ51387.1 - 0.0002 20.8 0.2 0.00051 19.5 0.2 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EAZ51387.1 - 0.00023 20.6 0.1 0.0003 20.2 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EAZ51387.1 - 0.0009 19.2 0.1 0.13 12.2 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EAZ51387.1 - 0.021 14.3 0.2 0.4 10.2 0.2 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 EAZ51387.1 - 0.045 13.3 0.0 0.099 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase PF00069.25 EAZ51388.1 - 1.8e-66 224.2 0.0 3.5e-66 223.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51388.1 - 2.2e-30 105.8 0.3 6.4e-29 101.0 0.3 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51388.1 - 5.4e-08 32.5 0.3 5.2e-07 29.3 0.2 2.5 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EAZ51388.1 - 0.0089 15.4 0.2 0.017 14.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EAZ51388.1 - 9 4.9 6.8 0.37 9.5 0.1 2.0 2 1 1 3 3 3 0 Fungal protein kinase GTP_EFTU PF00009.27 EAZ51390.1 - 4.7e-44 150.2 0.0 7.6e-44 149.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EAZ51390.1 - 8.7e-25 87.2 0.0 2.3e-24 85.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EAZ51390.1 - 1.6e-06 28.4 0.0 7.8e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EAZ51390.1 - 0.002 18.2 0.1 0.016 15.3 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNB PF00773.19 EAZ51391.1 - 2.6e-92 309.7 6.2 4.1e-92 309.0 6.2 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EAZ51391.1 - 1e-19 70.3 0.0 2.3e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EAZ51391.1 - 9.9e-10 38.5 0.3 5.5e-07 29.7 0.0 2.9 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EAZ51391.1 - 1.5e-08 34.5 0.6 6.3e-08 32.5 0.6 2.1 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rer1 PF03248.13 EAZ51392.1 - 5.2e-54 182.5 15.0 6.6e-54 182.2 15.0 1.1 1 0 0 1 1 1 1 Rer1 family EI24 PF07264.11 EAZ51392.1 - 0.17 12.1 8.8 0.21 11.8 8.8 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) 2TM PF13239.6 EAZ51392.1 - 8.3 6.8 14.6 5.7 7.3 2.9 2.3 2 0 0 2 2 2 0 2TM domain PhoLip_ATPase_C PF16212.5 EAZ51393.1 - 3e-42 145.1 24.2 3e-42 145.1 24.2 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EAZ51393.1 - 9.9e-17 60.4 3.4 9.9e-17 60.4 3.4 2.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EAZ51393.1 - 3e-11 43.2 1.2 8.2e-07 28.7 0.0 3.1 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase PF13246.6 EAZ51393.1 - 2.3e-10 40.4 0.0 8.5e-09 35.4 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EAZ51393.1 - 3e-09 37.5 0.0 0.00068 20.0 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EAZ51393.1 - 0.0015 18.3 0.6 0.005 16.6 0.6 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4392 PF14336.6 EAZ51393.1 - 0.15 11.5 0.2 0.28 10.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) Trm112p PF03966.16 EAZ51394.1 - 1.1e-07 32.3 0.0 1.4e-07 32.0 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Bromodomain PF00439.25 EAZ51395.1 - 4.1e-23 81.2 1.6 1.5e-22 79.5 0.2 2.1 2 0 0 2 2 2 1 Bromodomain BET PF17035.5 EAZ51395.1 - 0.015 15.5 0.1 0.038 14.2 0.1 1.7 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation Tam41_Mmp37 PF09139.11 EAZ51396.1 - 7.5e-19 68.3 0.9 8.2e-19 68.2 0.9 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Spt4 PF06093.13 EAZ51397.1 - 2.3e-30 104.5 0.3 3.6e-30 103.9 0.3 1.3 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Methyltransf_23 PF13489.6 EAZ51398.1 - 1.2e-12 48.0 0.0 2.6e-12 46.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAZ51398.1 - 1.5e-09 38.4 0.0 3.9e-08 33.8 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EAZ51398.1 - 8.5e-08 32.9 0.1 8e-07 29.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAZ51398.1 - 9.7e-08 31.9 0.1 1.2e-06 28.4 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EAZ51398.1 - 2.4e-07 31.4 0.0 3.6e-05 24.4 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EAZ51398.1 - 7.5e-05 22.3 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EAZ51398.1 - 0.00017 21.1 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 EAZ51398.1 - 0.079 11.9 0.0 0.52 9.2 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) NodS PF05401.11 EAZ51398.1 - 0.08 12.6 0.0 12 5.5 0.1 2.4 1 1 1 2 2 2 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 EAZ51398.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EAZ51398.1 - 0.2 10.9 1.2 10 5.3 0.0 2.4 1 1 1 2 2 2 0 Mycolic acid cyclopropane synthetase WD40 PF00400.32 EAZ51399.1 - 7.9e-12 45.5 3.8 0.0017 19.1 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51399.1 - 9.2e-06 25.9 0.1 0.44 10.9 0.0 3.6 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Metallophos PF00149.28 EAZ51400.1 - 3.7e-32 112.5 1.0 6.8e-32 111.6 1.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EAZ51400.1 - 1.8e-15 57.0 0.0 7.5e-15 55.0 0.1 2.0 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 EAZ51400.1 - 2.3e-13 49.4 5.3 0.00022 20.9 0.2 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EAZ51400.1 - 2.8e-11 42.6 0.7 0.014 15.4 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EAZ51400.1 - 7e-06 25.8 3.3 0.072 13.3 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EAZ51400.1 - 1.5e-05 24.6 0.2 0.089 12.5 0.3 2.7 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 EAZ51400.1 - 4.4e-05 23.7 0.5 0.0018 18.5 0.1 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EAZ51400.1 - 0.0051 17.1 0.1 0.098 13.1 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.6 EAZ51400.1 - 0.011 15.1 0.5 0.018 14.4 0.5 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP SusD-like_3 PF14322.6 EAZ51400.1 - 0.027 14.8 1.6 0.05 13.9 1.6 1.4 1 0 0 1 1 1 0 Starch-binding associating with outer membrane DUF2225 PF09986.9 EAZ51400.1 - 0.097 12.4 2.5 0.14 11.9 2.1 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 EAZ51400.1 - 0.098 13.3 0.8 4.3 8.2 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EAZ51400.1 - 0.1 12.9 1.9 0.29 11.4 1.9 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EAZ51400.1 - 0.19 11.8 0.1 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EAZ51400.1 - 0.34 11.0 2.1 1.1 9.4 0.3 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain SHS2_Rpb7-N PF03876.17 EAZ51401.1 - 4.8e-13 49.3 0.3 8.8e-13 48.4 0.0 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 EAZ51401.1 - 2.4e-06 27.8 0.0 3.5e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 S1 PF00575.23 EAZ51401.1 - 4.9e-06 26.8 0.5 1e-05 25.8 0.5 1.6 1 1 0 1 1 1 1 S1 RNA binding domain Ribosomal_L13e PF01294.18 EAZ51402.1 - 2.4e-68 229.6 2.7 2.8e-68 229.3 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L13e DNA_pol3_delta2 PF13177.6 EAZ51404.1 - 8.6e-09 35.4 0.0 1.7e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EAZ51404.1 - 0.0029 18.0 0.0 0.0062 17.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EAZ51404.1 - 0.011 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Pkinase PF00069.25 EAZ51405.1 - 1.7e-71 240.7 0.0 2.2e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51405.1 - 6.6e-41 140.3 0.0 8.9e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51405.1 - 0.0003 20.2 0.0 0.00049 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51405.1 - 0.019 13.8 0.0 0.035 12.9 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EAZ51405.1 - 0.047 13.0 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAZ51405.1 - 0.068 13.1 0.1 7.4 6.4 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DnaJ PF00226.31 EAZ51406.1 - 3.2e-25 88.0 1.0 6.4e-25 87.1 1.0 1.5 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 EAZ51406.1 - 4.3e-15 55.6 0.1 2.3e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 EAZ51406.1 - 5.2e-05 22.7 0.0 0.00024 20.6 0.1 2.0 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EAZ51406.1 - 0.033 14.1 0.1 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 AhpC/TSA family RAB3GAP2_N PF14655.6 EAZ51406.1 - 0.063 12.5 0.1 0.14 11.4 0.0 1.5 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Thioredoxin_8 PF13905.6 EAZ51406.1 - 0.071 13.4 0.6 32 4.9 0.0 3.6 3 1 1 4 4 4 0 Thioredoxin-like Thioredoxin_3 PF13192.6 EAZ51406.1 - 0.093 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin domain Dynamin_M PF01031.20 EAZ51407.1 - 1.1e-88 297.1 0.1 1.1e-88 297.1 0.1 2.2 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EAZ51407.1 - 4.8e-49 166.6 1.8 7.1e-49 166.1 0.1 2.2 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 EAZ51407.1 - 8.5e-27 93.1 2.6 8.5e-27 93.1 2.6 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EAZ51407.1 - 2.9e-06 27.4 0.0 1.2e-05 25.4 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EAZ51407.1 - 0.0038 17.4 0.1 0.15 12.3 0.0 2.9 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Peroxin-22 PF12827.7 EAZ51407.1 - 0.02 14.8 0.2 0.11 12.5 0.1 2.3 2 0 0 2 2 2 0 Peroxisomal biogenesis protein family FeoB_N PF02421.18 EAZ51407.1 - 0.076 12.5 0.1 4.8 6.7 0.0 2.7 2 0 0 2 2 2 0 Ferrous iron transport protein B GDPD_2 PF13653.6 EAZ51407.1 - 0.16 12.4 0.0 0.37 11.3 0.0 1.6 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Arf PF00025.21 EAZ51408.1 - 2.1e-77 258.5 0.2 2.4e-77 258.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EAZ51408.1 - 1.1e-14 54.6 0.0 1.6e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EAZ51408.1 - 1.1e-13 51.1 0.0 1.2e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EAZ51408.1 - 5.8e-13 48.7 0.0 7.1e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EAZ51408.1 - 2.7e-12 46.5 0.7 3.2e-08 33.1 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EAZ51408.1 - 3.2e-09 36.5 0.0 4e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EAZ51408.1 - 7.9e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EAZ51408.1 - 0.0082 15.5 0.1 0.017 14.5 0.1 1.4 1 1 0 1 1 1 1 6-phosphofructo-2-kinase cobW PF02492.19 EAZ51408.1 - 0.015 14.9 0.1 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EAZ51408.1 - 0.025 14.5 0.0 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 EAZ51408.1 - 0.042 13.4 0.1 0.11 12.0 0.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PDCD2_C PF04194.13 EAZ51409.1 - 4.7e-31 108.2 11.2 9.8e-31 107.2 0.1 2.5 3 0 0 3 3 3 2 Programmed cell death protein 2, C-terminal putative domain zf_C2H2_13 PF18508.1 EAZ51409.1 - 0.0092 15.6 1.0 0.22 11.1 0.1 2.6 2 0 0 2 2 2 1 Zinc finger domain CENP-B_dimeris PF09026.10 EAZ51409.1 - 3.5 8.1 10.0 6 7.3 10.0 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_S8 PF00082.22 EAZ51410.1 - 6.7e-28 97.8 0.5 9.5e-28 97.3 0.5 1.1 1 0 0 1 1 1 1 Subtilase family BOP1NT PF08145.12 EAZ51411.1 - 8.4e-77 258.6 5.2 1.5e-76 257.8 5.2 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EAZ51411.1 - 1.7e-07 31.8 4.4 9.3 7.3 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51411.1 - 0.00011 22.4 0.1 21 5.5 0.0 4.8 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF5453 PF17534.2 EAZ51411.1 - 0.1 12.5 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5453) NIF PF03031.18 EAZ51412.1 - 8.1e-45 152.4 0.0 8.1e-45 152.4 0.0 1.9 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase ER PF01133.17 EAZ51413.1 - 7.3e-34 115.7 2.8 8.2e-34 115.5 2.8 1.0 1 0 0 1 1 1 1 Enhancer of rudimentary DUF4709 PF15821.5 EAZ51413.1 - 0.03 14.6 0.0 1.1 9.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4709) PS_Dcarbxylase PF02666.15 EAZ51413.1 - 0.038 13.5 0.0 0.038 13.5 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylserine decarboxylase Rx_N PF18052.1 EAZ51413.1 - 0.087 13.1 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Rx N-terminal domain Delta_lysin PF05372.11 EAZ51413.1 - 0.13 11.6 0.4 11 5.4 0.5 2.4 2 0 0 2 2 2 0 Delta lysin family DS PF01916.17 EAZ51414.1 - 4.4e-129 429.8 0.0 5.1e-129 429.6 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Rad51 PF08423.11 EAZ51415.1 - 3.6e-23 82.1 0.0 8.5e-23 80.9 0.0 1.5 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 EAZ51415.1 - 8.1e-07 28.6 1.0 6.4e-05 22.4 0.1 2.4 2 1 0 2 2 2 2 KaiC RecA PF00154.21 EAZ51415.1 - 0.0012 18.4 0.0 0.0028 17.2 0.0 1.5 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 EAZ51415.1 - 0.0017 18.1 0.1 1.4 8.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EAZ51415.1 - 0.017 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pro_isomerase PF00160.21 EAZ51416.1 - 1.9e-49 168.0 0.0 2.2e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EAZ51416.1 - 0.037 14.1 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain Rho_N PF07498.12 EAZ51417.1 - 2.1e-05 24.3 1.7 3.8e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 Rho termination factor, N-terminal domain HeH PF12949.7 EAZ51417.1 - 0.0034 17.0 0.1 0.014 15.1 0.1 2.1 1 0 0 1 1 1 1 HeH/LEM domain SAP PF02037.27 EAZ51417.1 - 0.0036 17.0 0.1 0.014 15.2 0.1 2.1 1 0 0 1 1 1 1 SAP domain DUF572 PF04502.13 EAZ51417.1 - 1 8.9 32.5 1.3 8.6 32.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Sybindin PF04099.12 EAZ51418.1 - 1.6e-41 141.6 0.1 1.8e-41 141.4 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EAZ51418.1 - 5.9e-07 29.7 0.0 8.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Pkinase PF00069.25 EAZ51419.1 - 4.8e-61 206.4 1.2 1.5e-52 178.6 0.6 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51419.1 - 1.2e-27 96.9 0.2 1.3e-23 83.6 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EAZ51419.1 - 0.0011 18.0 0.2 0.0021 17.1 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EAZ51419.1 - 0.095 12.0 0.1 0.3 10.4 0.1 1.9 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family adh_short PF00106.25 EAZ51420.1 - 3.9e-34 117.8 0.0 5e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EAZ51420.1 - 2e-32 112.6 0.0 2.9e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EAZ51420.1 - 8.2e-08 32.4 0.1 4.1e-07 30.1 0.1 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EAZ51420.1 - 2.6e-06 27.1 0.0 6e-05 22.6 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EAZ51420.1 - 1.4e-05 24.3 1.6 6.7e-05 22.0 1.6 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EAZ51420.1 - 2.1e-05 23.8 0.6 9e-05 21.7 0.6 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EAZ51420.1 - 0.0042 16.3 0.2 1 8.5 0.2 3.0 2 1 0 2 2 2 1 Male sterility protein DUF1776 PF08643.10 EAZ51420.1 - 0.065 12.6 0.0 0.095 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Peptidase_C1 PF00112.23 EAZ51421.1 - 7.9e-41 140.5 7.1 1e-40 140.1 7.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EAZ51421.1 - 0.0015 17.4 2.3 0.0015 17.4 0.3 1.8 2 0 0 2 2 2 1 Peptidase C1-like family FeoB_associated PF12669.7 EAZ51421.1 - 0.33 11.4 5.0 20 5.7 0.0 2.8 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein KH_6 PF15985.5 EAZ51422.1 - 6.4e-10 39.2 0.0 1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 KH domain RNA_pol_Rpb1_1 PF04997.12 EAZ51422.1 - 0.0031 16.9 0.0 0.0042 16.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 Flavoprotein PF02441.19 EAZ51423.1 - 1.8e-53 180.5 0.0 2.1e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein NAD_binding_7 PF13241.6 EAZ51423.1 - 0.096 13.1 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase PF00069.25 EAZ51424.1 - 5.2e-82 275.2 0.9 5.7e-82 275.0 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51424.1 - 4.2e-43 147.5 0.0 6.4e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EAZ51424.1 - 6.2e-25 84.8 11.1 1.3e-06 27.5 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EAZ51424.1 - 1.6e-24 86.1 10.7 7.2e-13 48.8 2.5 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EAZ51424.1 - 5.2e-20 69.6 9.9 7.4e-07 28.6 0.4 4.9 3 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EAZ51424.1 - 1.4e-18 65.5 11.5 6.4e-05 22.3 0.3 4.9 4 1 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EAZ51424.1 - 5.2e-17 61.4 9.8 0.0013 18.5 0.0 4.5 2 1 2 4 4 4 4 EF-hand domain pair Pkinase_fungal PF17667.1 EAZ51424.1 - 5.3e-07 28.8 0.0 1.2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EAZ51424.1 - 6.5e-07 28.9 0.3 1.8e-06 27.5 0.3 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EAZ51424.1 - 1.1e-05 24.9 0.0 0.028 13.7 0.0 2.8 1 1 1 2 2 2 2 Kinase-like EF-hand_4 PF12763.7 EAZ51424.1 - 3.9e-05 23.5 6.2 0.1 12.6 0.7 3.7 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EAZ51424.1 - 0.0001 22.6 1.0 0.41 11.0 0.2 2.6 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EAZ51424.1 - 0.0039 17.5 0.5 0.068 13.5 0.0 2.8 3 0 0 3 3 2 1 EF-hand domain FTA2 PF13095.6 EAZ51424.1 - 0.0091 15.6 0.2 4.4 6.9 0.0 2.5 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EAZ51424.1 - 0.01 15.7 0.0 0.036 14.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EAZ51424.1 - 0.024 13.6 1.0 0.13 11.2 1.0 2.2 1 1 0 1 1 1 0 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 EAZ51424.1 - 0.034 13.7 0.1 0.095 12.2 0.1 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL EF-hand_10 PF14788.6 EAZ51424.1 - 0.36 10.7 2.5 1.5 8.8 0.0 3.0 2 1 0 2 2 2 0 EF hand Rhomboid PF01694.22 EAZ51425.1 - 2.2e-29 102.4 13.6 3.1e-29 101.9 13.6 1.2 1 0 0 1 1 1 1 Rhomboid family DER1 PF04511.15 EAZ51425.1 - 0.00099 19.1 3.9 0.002 18.1 4.0 1.5 1 1 0 1 1 1 1 Der1-like family Aminotran_5 PF00266.19 EAZ51426.1 - 2.8e-26 92.4 0.0 7.7e-19 67.9 0.0 3.0 3 0 0 3 3 3 2 Aminotransferase class-V ATP_bind_3 PF01171.20 EAZ51426.1 - 6.5e-16 58.6 0.0 1.4e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 PP-loop family SHMT PF00464.19 EAZ51426.1 - 0.00092 17.9 0.0 0.0017 17.1 0.0 1.3 1 0 0 1 1 1 1 Serine hydroxymethyltransferase zf-C2H2_2 PF12756.7 EAZ51426.1 - 0.042 14.2 3.8 0.078 13.3 0.3 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EAZ51426.1 - 0.5 10.7 6.0 0.25 11.7 1.6 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EAZ51426.1 - 1.9 9.5 10.0 1.5 9.9 0.9 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger DUF913 PF06025.12 EAZ51427.1 - 3.1e-16 59.3 3.7 3.1e-16 59.3 3.7 5.0 4 1 0 4 4 4 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EAZ51427.1 - 5e-09 36.0 0.6 5e-09 36.0 0.6 4.1 5 0 0 5 5 5 1 Domain of Unknown Function (DUF908) EF-hand_7 PF13499.6 EAZ51428.1 - 1.7e-23 82.8 8.4 4.3e-13 49.5 3.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EAZ51428.1 - 3.6e-22 76.2 16.0 7.8e-09 34.5 1.1 4.7 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EAZ51428.1 - 3.2e-19 67.2 8.5 3.8e-05 23.3 0.1 4.8 4 1 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EAZ51428.1 - 4.1e-17 61.8 9.2 9e-14 51.1 0.7 4.0 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 EAZ51428.1 - 1.1e-11 44.8 0.1 7.9e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EAZ51428.1 - 7.9e-06 25.8 2.5 0.044 13.7 0.8 2.5 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EAZ51428.1 - 3.1e-05 23.3 14.8 0.00091 18.6 1.4 4.6 5 1 0 5 5 5 2 EF hand SurA_N_2 PF13623.6 EAZ51428.1 - 0.048 13.5 0.7 0.48 10.3 0.1 2.3 2 0 0 2 2 2 0 SurA N-terminal domain SurA_N_3 PF13624.6 EAZ51428.1 - 0.055 13.3 1.6 0.17 11.7 0.7 1.9 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_14 PF17959.1 EAZ51428.1 - 0.06 13.7 1.0 1.2 9.5 0.3 2.4 1 1 1 2 2 2 0 EF-hand domain Toprim_2 PF13155.6 EAZ51428.1 - 0.085 13.3 0.4 0.7 10.4 0.1 2.3 1 1 2 3 3 3 0 Toprim-like B5 PF03484.15 EAZ51428.1 - 0.087 13.1 1.3 18 5.7 0.0 3.0 2 2 0 2 2 2 0 tRNA synthetase B5 domain DUF2767 PF10965.8 EAZ51428.1 - 0.089 12.8 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2767) MgtE_N PF03448.17 EAZ51428.1 - 0.13 12.9 1.4 0.18 12.5 0.4 1.8 2 0 0 2 2 1 0 MgtE intracellular N domain SUB1_ProdP9 PF18213.1 EAZ51428.1 - 0.17 11.7 2.4 1.2 9.0 0.5 2.4 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 SPARC_Ca_bdg PF10591.9 EAZ51428.1 - 0.27 11.5 1.1 0.5 10.7 0.5 1.8 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region HTH_40 PF14493.6 EAZ51428.1 - 0.39 11.2 3.1 1.2 9.7 0.5 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain Pkinase PF00069.25 EAZ51429.1 - 1.2e-70 237.9 0.0 1.3e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51429.1 - 1.3e-34 119.7 0.0 1.6e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EAZ51429.1 - 0.0036 17.3 0.0 0.0079 16.1 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EAZ51429.1 - 0.034 13.7 0.0 0.079 12.5 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 EAZ51429.1 - 0.13 11.2 0.0 0.35 9.8 0.0 1.7 1 1 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EAZ51429.1 - 0.16 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Profilin PF00235.19 EAZ51430.1 - 6.8e-22 78.1 0.7 1e-21 77.5 0.7 1.2 1 0 0 1 1 1 1 Profilin SPC22 PF04573.12 EAZ51430.1 - 0.063 12.8 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 Signal peptidase subunit Pkinase PF00069.25 EAZ51431.1 - 3.7e-26 92.1 0.0 4.8e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51431.1 - 9.2e-17 61.2 0.0 1.2e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EAZ51431.1 - 1.7e-09 37.0 0.0 2.3e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EAZ51431.1 - 0.00047 20.2 0.0 0.0024 17.8 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EAZ51431.1 - 0.027 13.4 0.4 0.042 12.8 0.4 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SKG6 PF08693.10 EAZ51431.1 - 5.3 6.5 7.5 0.36 10.3 1.5 2.1 2 0 0 2 2 2 0 Transmembrane alpha-helix domain NUDIX PF00293.28 EAZ51432.1 - 6.7e-07 29.4 0.1 7.5e-07 29.3 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain UDPG_MGDP_dh_C PF03720.15 EAZ51432.1 - 0.034 14.6 0.0 0.042 14.3 0.0 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PS_Dcarbxylase PF02666.15 EAZ51434.1 - 1.9e-55 187.5 0.0 2.3e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase KGK PF08872.10 EAZ51434.1 - 0.055 13.9 0.8 0.23 11.9 0.2 2.3 2 1 0 2 2 2 0 KGK domain UQ_con PF00179.26 EAZ51435.1 - 6.8e-48 161.9 0.0 7.6e-48 161.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EAZ51435.1 - 0.0094 15.7 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EAZ51435.1 - 0.012 15.5 0.1 0.022 14.6 0.1 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 EAZ51435.1 - 0.031 14.6 0.1 0.038 14.3 0.1 1.3 1 0 0 1 1 1 0 RWD domain RRM_1 PF00076.22 EAZ51436.1 - 1.3e-14 53.7 0.0 1.6e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDEase_I PF00233.19 EAZ51437.1 - 4.1e-66 223.1 0.0 9.2e-66 222.0 0.0 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF1053 PF06327.14 EAZ51437.1 - 0.17 12.4 0.4 1.1 9.9 0.6 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1053) PsbH PF00737.20 EAZ51437.1 - 0.26 11.0 1.0 0.87 9.4 1.0 1.9 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein DEAD PF00270.29 EAZ51438.1 - 2e-44 151.4 0.0 4.5e-44 150.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51438.1 - 8.2e-27 93.8 0.1 4.5e-26 91.4 0.1 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EAZ51438.1 - 4.4e-09 36.4 5.5 1.2e-08 35.0 5.5 1.8 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ERCC3_RAD25_C PF16203.5 EAZ51438.1 - 1.4e-07 31.0 0.2 3e-07 29.9 0.2 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 EAZ51438.1 - 0.078 13.3 0.2 0.28 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain SH3BGR PF04908.15 EAZ51438.1 - 0.64 10.2 3.7 5 7.3 0.1 3.0 3 0 0 3 3 3 0 SH3-binding, glutamic acid-rich protein DUF536 PF04394.14 EAZ51438.1 - 3.6 7.5 7.3 21 5.1 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF536 adh_short PF00106.25 EAZ51439.1 - 1.3e-39 135.7 0.0 1.5e-39 135.5 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EAZ51439.1 - 6.7e-23 81.5 0.0 8.2e-23 81.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EAZ51439.1 - 8.9e-06 25.7 0.0 1.4e-05 25.1 0.0 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EAZ51439.1 - 1.7e-05 24.4 0.0 2.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EAZ51439.1 - 0.011 14.9 0.0 0.048 12.8 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EAZ51439.1 - 0.094 13.0 0.0 0.26 11.6 0.0 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EAZ51439.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 2 0 0 2 2 2 0 NAD(P)H-binding DUF659 PF04937.15 EAZ51440.1 - 0.007 16.2 0.3 0.0082 16.0 0.3 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) KRBA1 PF15287.6 EAZ51440.1 - 0.74 9.6 1.9 1.3 8.8 1.9 1.3 1 0 0 1 1 1 0 KRBA1 family repeat UbiA PF01040.18 EAZ51441.1 - 1.9e-06 27.3 0.2 2.6e-06 26.9 0.2 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Kinesin PF00225.23 EAZ51442.1 - 9.1e-100 333.8 5.3 9.1e-100 333.8 5.3 2.1 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EAZ51442.1 - 1.2e-49 168.0 0.3 1.2e-49 168.0 0.3 2.5 2 1 0 2 2 2 1 Microtubule binding DUF948 PF06103.11 EAZ51442.1 - 0.76 10.1 7.6 1.7 8.9 4.3 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TMPIT PF07851.13 EAZ51442.1 - 1.6 7.9 8.5 3.4 6.8 8.5 1.7 1 0 0 1 1 1 0 TMPIT-like protein YvrJ PF12841.7 EAZ51442.1 - 2 8.0 5.5 18 5.0 0.4 3.0 2 0 0 2 2 2 0 YvrJ protein family CREPT PF16566.5 EAZ51442.1 - 4 7.6 16.0 0.26 11.5 9.7 2.3 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TRAPP PF04051.16 EAZ51443.1 - 3.7e-32 111.1 0.0 4.6e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF2399 PF09664.10 EAZ51444.1 - 2.7e-06 27.4 0.0 4.3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) DUF2220 PF09983.9 EAZ51444.1 - 0.0027 17.1 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria C-term(DUF2220) Pkinase_Tyr PF07714.17 EAZ51445.1 - 6.1e-44 150.3 0.0 7.5e-43 146.7 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EAZ51445.1 - 7.4e-43 146.8 0.0 3.4e-40 138.1 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 EAZ51445.1 - 0.07 11.9 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PVL_ORF50 PF07768.11 EAZ51445.1 - 0.14 12.5 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 PVL ORF-50-like family Pkinase PF00069.25 EAZ51446.1 - 1.1e-68 231.5 0.0 1.6e-68 231.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51446.1 - 1.3e-32 113.2 0.0 2.2e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EAZ51446.1 - 0.0032 16.5 0.3 0.0076 15.2 0.3 1.6 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EAZ51446.1 - 0.0032 16.8 0.4 0.01 15.2 0.4 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EAZ51446.1 - 0.046 13.3 0.5 0.21 11.2 0.1 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase PF00069.25 EAZ51447.1 - 5.5e-70 235.8 0.0 6.7e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51447.1 - 9.8e-35 120.1 0.0 1.3e-34 119.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51447.1 - 2.6e-05 23.7 0.0 6.5e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EAZ51447.1 - 0.038 13.1 0.0 0.057 12.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kinesin PF00225.23 EAZ51448.1 - 5.7e-85 285.2 10.8 3.7e-84 282.5 10.8 2.2 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EAZ51448.1 - 3.2e-17 62.8 10.0 3.7e-16 59.4 0.2 3.8 2 2 0 2 2 2 1 Microtubule binding Amino_oxidase PF01593.24 EAZ51449.1 - 1.3 8.2 3.7 2 7.6 2.9 1.8 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase CRISPR_Cas2 PF09827.9 EAZ51449.1 - 7.4 6.8 7.7 5.6 7.2 0.3 4.1 3 0 0 3 3 3 0 CRISPR associated protein Cas2 DUF489 PF04356.12 EAZ51449.1 - 8.9 6.3 22.9 0.86 9.6 7.2 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF489) Arb1 PF09692.10 EAZ51450.1 - 0.035 13.3 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 LNS2 PF08235.13 EAZ51451.1 - 7.2e-89 297.1 0.0 1e-88 296.6 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EAZ51451.1 - 4.1e-32 110.2 0.0 8.8e-32 109.1 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 EAZ51451.1 - 7e-15 55.0 0.0 1.3e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Acid_phosphat_B PF03767.14 EAZ51451.1 - 0.12 11.9 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) zf-C2HC5 PF06221.13 EAZ51452.1 - 0.011 15.7 9.7 0.41 10.7 9.7 2.3 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Kelch_4 PF13418.6 EAZ51453.1 - 1.2e-35 121.2 4.8 1.1e-09 38.2 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EAZ51453.1 - 1.5e-30 104.8 5.8 3.6e-07 30.3 0.0 7.3 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EAZ51453.1 - 2.5e-29 100.7 9.0 4.1e-07 29.8 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EAZ51453.1 - 2.7e-24 84.1 7.0 2.2e-06 27.4 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EAZ51453.1 - 2.6e-23 81.4 9.2 2e-06 27.3 0.0 6.2 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 EAZ51453.1 - 3.2e-22 78.8 4.0 4.2e-22 78.5 1.7 2.1 1 1 1 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.6 EAZ51453.1 - 5.5e-22 77.2 7.7 0.00057 20.1 0.0 6.3 5 1 1 6 6 6 6 Kelch motif DUF1265 PF06887.14 EAZ51453.1 - 0.016 15.2 10.3 0.59 10.1 0.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1265) BACK PF07707.15 EAZ51453.1 - 0.026 14.6 0.4 0.55 10.4 0.1 2.7 2 0 0 2 2 2 0 BTB And C-terminal Kelch DEAD PF00270.29 EAZ51454.1 - 4.8e-45 153.5 0.2 1e-44 152.4 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51454.1 - 4e-29 101.2 2.4 1e-28 99.9 0.3 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51454.1 - 0.0003 20.8 0.0 0.0009 19.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit WYL_2 PF10902.8 EAZ51454.1 - 0.17 12.3 0.4 0.36 11.2 0.4 1.6 1 0 0 1 1 1 0 WYL_2, Sm-like SH3 beta-barrel fold E1-E2_ATPase PF00122.20 EAZ51455.1 - 8.5e-34 116.6 2.3 1e-32 113.1 0.4 2.5 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EAZ51455.1 - 2.4e-06 27.9 0.5 8.3e-06 26.2 0.5 2.0 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase PF00702.26 EAZ51455.1 - 0.00026 21.4 0.0 0.0014 18.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase LepB_GAP_C PF18227.1 EAZ51455.1 - 0.24 12.0 2.4 16 6.1 0.0 3.1 3 0 0 3 3 3 0 LepB GAP domain C-terminal subdomain tRNA-synt_1 PF00133.22 EAZ51456.1 - 3.8e-214 712.4 0.7 3.3e-213 709.3 0.1 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EAZ51456.1 - 2.5e-27 95.7 2.6 1e-25 90.5 0.5 2.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EAZ51456.1 - 6.8e-14 51.4 3.1 0.00031 19.6 0.1 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EAZ51456.1 - 2.4e-05 23.8 0.0 0.00019 20.9 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain ZapD PF07072.11 EAZ51456.1 - 0.2 11.4 1.7 3.5 7.3 0.3 2.3 2 0 0 2 2 2 0 Cell division protein Stap_Strp_toxin PF01123.20 EAZ51456.1 - 0.79 10.6 5.1 1.7 9.5 0.0 3.5 3 0 0 3 3 3 0 Staphylococcal/Streptococcal toxin, OB-fold domain DEAD PF00270.29 EAZ51457.1 - 1.2e-47 161.9 0.3 4.5e-47 160.1 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51457.1 - 3.3e-23 82.2 0.0 2.4e-22 79.4 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EAZ51457.1 - 8.3e-17 61.2 0.8 1.6e-16 60.3 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EAZ51457.1 - 9.2e-06 25.8 0.0 4.1e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EAZ51457.1 - 0.046 13.4 0.0 1.3 8.7 0.0 2.4 1 1 0 1 1 1 0 AAA domain Cnd2 PF05786.14 EAZ51458.1 - 8.1e-15 54.6 35.4 5.6e-10 38.6 24.4 2.9 2 1 0 2 2 2 2 Condensin complex subunit 2 TraC_F_IV PF11130.8 EAZ51458.1 - 0.024 14.3 0.3 0.046 13.3 0.3 1.4 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer WYL_3 PF18488.1 EAZ51458.1 - 0.15 12.5 0.6 2.5 8.5 0.1 2.9 2 0 0 2 2 2 0 WYL domain RRM_1 PF00076.22 EAZ51459.1 - 6.6e-36 122.0 0.0 3.3e-18 65.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAZ51459.1 - 5.4e-06 26.2 0.0 2.5e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EAZ51459.1 - 0.016 15.2 1.7 1.4 9.0 0.0 3.7 3 0 0 3 3 3 0 RNA binding motif Nup35_RRM_2 PF14605.6 EAZ51459.1 - 0.057 13.4 0.0 2.2 8.3 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Pkinase PF00069.25 EAZ51460.1 - 8.4e-31 107.3 0.0 1.9e-30 106.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51460.1 - 3.3e-30 105.2 0.0 5.5e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase tRNA-synt_1c PF00749.21 EAZ51461.1 - 1.5e-109 365.7 0.0 1.9e-109 365.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EAZ51461.1 - 2.6e-36 125.1 0.0 8e-36 123.5 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain Coatomer_WDAD PF04053.14 EAZ51462.1 - 1.1e-62 212.6 16.2 9.6e-58 196.3 4.2 2.9 3 1 0 3 3 3 2 Coatomer WD associated region COPI_C PF06957.11 EAZ51462.1 - 1.3e-60 205.3 0.4 2.4e-60 204.4 0.0 1.5 2 0 0 2 2 2 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EAZ51462.1 - 7.7e-42 140.5 24.1 8.6e-08 32.7 0.9 8.5 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51462.1 - 1.1e-11 44.8 1.7 6.4e-06 26.4 0.1 5.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 EAZ51462.1 - 0.12 12.5 0.0 1.5 9.1 0.0 2.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Ras PF00071.22 EAZ51463.1 - 7.9e-57 191.4 0.1 9.4e-57 191.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51463.1 - 1.2e-31 109.4 0.1 2.1e-31 108.6 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51463.1 - 5.7e-14 51.9 0.0 7.3e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EAZ51463.1 - 3.5e-05 23.4 0.1 0.0044 16.6 0.1 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EAZ51463.1 - 0.00027 21.0 0.0 0.00042 20.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EAZ51463.1 - 0.0016 18.3 0.0 0.41 10.4 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EAZ51463.1 - 0.017 15.1 0.1 2.5 8.0 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EAZ51463.1 - 0.023 14.5 0.1 0.27 11.0 0.1 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EAZ51463.1 - 0.023 14.1 0.0 0.036 13.4 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DAP3 PF10236.9 EAZ51463.1 - 0.07 12.3 0.0 0.23 10.6 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 EAZ51463.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 EAZ51463.1 - 0.083 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Septin Pkinase PF00069.25 EAZ51464.1 - 3.8e-29 101.8 0.0 1.3e-15 57.5 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51464.1 - 5.9e-08 32.3 0.0 1.9e-06 27.4 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51464.1 - 2.1e-07 30.6 2.3 1.9e-06 27.4 0.6 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51464.1 - 0.0026 16.6 0.0 0.0051 15.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EAZ51464.1 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAZ51464.1 - 0.025 14.5 0.1 0.057 13.3 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family ANKH PF07260.11 EAZ51464.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Progressive ankylosis protein (ANKH) DEAD PF00270.29 EAZ51465.1 - 1e-43 149.1 0.0 1.5e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EAZ51465.1 - 2.9e-28 98.4 0.8 2e-27 95.7 0.4 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51465.1 - 0.00038 20.5 0.0 0.00072 19.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit S4 PF01479.25 EAZ51466.1 - 1.6e-11 43.8 0.6 3.2e-11 42.7 0.6 1.5 1 0 0 1 1 1 1 S4 domain Aha1_N PF09229.11 EAZ51467.1 - 1.3e-15 57.8 0.1 1.3e-15 57.8 0.1 2.4 2 1 0 2 2 1 1 Activator of Hsp90 ATPase, N-terminal TPR_2 PF07719.17 EAZ51467.1 - 2.4e-13 49.1 2.0 9.5e-05 22.2 0.0 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EAZ51467.1 - 4.7e-12 45.4 1.1 0.0022 17.6 0.0 3.4 3 0 0 3 3 3 3 TPR repeat TPR_1 PF00515.28 EAZ51467.1 - 9.9e-12 44.2 4.7 5.8e-06 25.9 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 EAZ51467.1 - 1.3e-07 31.8 2.2 0.064 13.9 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EAZ51467.1 - 4.8e-06 27.1 0.0 0.019 15.6 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EAZ51467.1 - 1.7e-05 24.8 0.8 0.035 14.2 0.1 3.5 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 EAZ51467.1 - 2.6e-05 24.3 0.0 0.00011 22.2 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAZ51467.1 - 3e-05 23.9 0.1 0.0041 17.2 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EAZ51467.1 - 0.00053 19.8 0.5 0.38 10.9 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EAZ51467.1 - 0.00083 19.6 0.0 2.8 8.5 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EAZ51467.1 - 0.0098 16.6 0.1 0.52 11.3 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EAZ51467.1 - 0.017 15.6 2.2 0.48 11.0 0.3 2.9 2 1 1 3 3 2 0 Tetratricopeptide repeat MIT PF04212.18 EAZ51467.1 - 0.027 14.5 0.4 0.027 14.5 0.4 3.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 EAZ51467.1 - 0.14 12.4 0.4 20 5.5 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Pro_isomerase PF00160.21 EAZ51468.1 - 1.9e-34 119.2 0.0 2.6e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EAZ51468.1 - 1.7e-15 56.5 0.2 4.7e-15 55.2 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CKS PF01111.19 EAZ51470.1 - 2.5e-20 72.5 0.2 2.7e-20 72.4 0.2 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit KH_6 PF15985.5 EAZ51471.1 - 1.5e-10 41.3 0.1 2.5e-10 40.5 0.1 1.4 1 0 0 1 1 1 1 KH domain DUF2892 PF11127.8 EAZ51472.1 - 0.22 11.6 2.7 0.39 10.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2892) Pkinase PF00069.25 EAZ51473.1 - 6.9e-61 205.9 0.4 4.1e-60 203.4 0.4 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51473.1 - 4e-22 78.8 0.5 3e-20 72.6 0.5 2.8 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EAZ51473.1 - 0.00032 20.4 0.2 0.073 12.7 0.0 2.5 2 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EAZ51473.1 - 0.00042 19.2 0.1 0.00057 18.8 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EAZ51473.1 - 0.002 17.5 0.0 0.0056 16.1 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EAZ51473.1 - 0.071 12.6 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 EAZ51473.1 - 0.21 11.5 0.0 0.39 10.6 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family PTH2 PF01981.16 EAZ51474.1 - 6e-34 116.8 0.0 6.6e-34 116.7 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 AsnC_trans_reg PF01037.21 EAZ51474.1 - 0.0015 18.4 0.0 0.0043 17.0 0.0 1.7 2 0 0 2 2 2 1 Lrp/AsnC ligand binding domain TPR_14 PF13428.6 EAZ51474.1 - 0.098 13.5 0.0 0.46 11.4 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PIP5K PF01504.18 EAZ51475.1 - 2.9e-78 262.9 9.0 2.9e-78 262.9 9.0 2.4 2 2 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.32 EAZ51475.1 - 0.00072 18.9 0.4 0.0032 16.9 0.4 2.2 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EAZ51475.1 - 0.00097 18.9 0.1 0.0044 16.8 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 EAZ51475.1 - 0.0093 15.8 1.7 0.026 14.4 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 EAZ51475.1 - 0.15 12.6 2.2 1.2 9.6 2.2 2.5 1 1 0 1 1 1 0 EF-hand domain pair PTH2 PF01981.16 EAZ51476.1 - 1.5e-17 63.9 0.0 1.8e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 HEPN_RiboL-PSP PF18735.1 EAZ51476.1 - 0.054 13.4 0.0 0.059 13.3 0.0 1.1 1 0 0 1 1 1 0 RiboL-PSP-HEPN PrmA PF06325.13 EAZ51477.1 - 1.9e-10 40.7 0.1 2.8e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EAZ51477.1 - 4.5e-09 36.9 0.1 1.8e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EAZ51477.1 - 4.5e-08 33.6 0.0 1.5e-07 32.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EAZ51477.1 - 3.9e-07 30.0 0.0 5e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EAZ51477.1 - 1.3e-06 28.3 0.5 4.7e-06 26.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EAZ51477.1 - 3.5e-05 23.4 0.1 6e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EAZ51477.1 - 0.00089 20.0 0.0 0.0022 18.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EAZ51477.1 - 0.0028 17.5 0.1 0.004 16.9 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.7 EAZ51477.1 - 0.0031 17.5 0.1 0.0064 16.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EAZ51477.1 - 0.0036 16.6 0.1 0.0056 16.0 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 EAZ51477.1 - 0.0042 16.1 0.0 0.0093 14.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) PRMT5 PF05185.16 EAZ51477.1 - 0.033 14.0 0.1 0.055 13.3 0.1 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase FtsJ PF01728.19 EAZ51477.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EAZ51477.1 - 0.068 12.9 0.2 0.16 11.7 0.2 1.6 1 0 0 1 1 1 0 Lysine methyltransferase UFC1 PF08694.11 EAZ51478.1 - 1.1e-70 236.3 0.2 1.2e-70 236.1 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 EAZ51478.1 - 0.02 14.6 0.1 0.034 13.8 0.1 1.4 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme ANAPC4_WD40 PF12894.7 EAZ51479.1 - 9.7e-13 48.2 0.0 0.0046 17.2 0.0 4.8 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EAZ51479.1 - 5.7e-12 46.0 9.5 0.87 10.6 0.0 7.2 6 1 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.11 EAZ51479.1 - 7.4e-08 32.5 0.3 0.067 13.1 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EAZ51479.1 - 1.4e-05 24.6 2.2 0.047 13.0 0.4 3.1 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 EAZ51479.1 - 7.2e-05 22.6 0.5 2.8 8.0 0.0 4.5 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat IKI3 PF04762.12 EAZ51479.1 - 0.12 10.3 0.1 1.3 6.9 0.1 2.1 1 1 0 1 1 1 0 IKI3 family Proteasome_A_N PF10584.9 EAZ51479.1 - 0.15 11.7 0.0 0.15 11.7 0.0 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 EAZ51480.1 - 4.3e-17 62.2 20.8 0.0015 19.3 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51480.1 - 1.1e-05 25.6 0.7 5 7.5 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 EAZ51480.1 - 0.005 14.9 0.8 0.0091 14.0 0.6 1.3 1 1 0 1 1 1 1 IKI3 family BBS2_Mid PF14783.6 EAZ51480.1 - 0.013 15.5 0.0 5.9 7.0 0.0 3.3 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region adh_short PF00106.25 EAZ51481.1 - 5.5e-24 84.7 0.0 7.1e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EAZ51481.1 - 3e-16 59.7 0.0 3.9e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EAZ51481.1 - 3.8e-05 23.7 0.0 5e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EAZ51481.1 - 0.0086 15.6 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EAZ51481.1 - 0.015 14.7 0.1 0.023 14.1 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF2626 PF11117.8 EAZ51481.1 - 0.18 12.5 10.4 2.3 9.0 1.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2626) Cnd1_N PF12922.7 EAZ51482.1 - 0.061 13.2 1.0 0.083 12.7 1.0 1.2 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term DUF4710 PF15828.5 EAZ51482.1 - 0.082 13.0 2.8 0.15 12.2 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) Ferlin_C PF16165.5 EAZ51482.1 - 0.4 10.6 4.1 0.55 10.2 4.1 1.2 1 0 0 1 1 1 0 Ferlin C-terminus Rcd1 PF04078.13 EAZ51483.1 - 6.3e-119 396.0 0.5 7.4e-119 395.8 0.5 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like FlgH PF02107.16 EAZ51483.1 - 0.031 13.9 1.4 0.049 13.3 1.4 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein Sec23_trunk PF04811.15 EAZ51484.1 - 3e-58 197.3 0.0 4.6e-58 196.6 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EAZ51484.1 - 8e-17 61.8 0.0 2.9e-16 60.0 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EAZ51484.1 - 1.1e-14 54.2 3.1 2.3e-14 53.1 3.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EAZ51484.1 - 6.6e-14 51.6 0.4 3.6e-13 49.2 0.4 2.1 1 1 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EAZ51484.1 - 2.4e-06 27.4 0.0 1.3e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EAZ51484.1 - 0.12 11.7 0.1 0.31 10.5 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-RanBP PF00641.18 EAZ51484.1 - 0.14 11.5 0.2 0.39 10.1 0.2 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others WD40 PF00400.32 EAZ51485.1 - 1.9e-11 44.3 4.3 0.0014 19.4 0.3 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat RIO1 PF01163.22 EAZ51486.1 - 3.5e-11 43.0 0.2 5e-11 42.5 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 EAZ51486.1 - 4.3e-10 39.4 2.9 6.2e-10 38.9 2.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51486.1 - 9.1e-10 38.3 0.4 1.1e-09 37.9 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EAZ51486.1 - 4.5e-08 32.7 0.0 7.9e-08 31.9 0.0 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EAZ51486.1 - 0.00025 21.0 0.1 0.011 15.6 1.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EAZ51486.1 - 0.00036 19.9 0.6 0.00059 19.2 0.6 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EAZ51486.1 - 0.071 12.7 3.3 0.15 11.6 3.0 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EAZ51486.1 - 0.15 10.8 2.2 0.2 10.4 2.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase Fcf1 PF04900.12 EAZ51487.1 - 3.1e-23 82.0 0.3 9.3e-14 51.6 0.0 2.2 1 1 1 2 2 2 2 Fcf1 Pro-MCH PF05824.12 EAZ51487.1 - 0.044 13.7 0.2 0.21 11.6 0.2 2.1 1 1 1 2 2 2 0 Pro-melanin-concentrating hormone (Pro-MCH) zf-RING_UBOX PF13445.6 EAZ51487.1 - 0.091 12.8 0.1 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 RING-type zinc-finger Clat_adaptor_s PF01217.20 EAZ51488.1 - 1.7e-42 144.7 6.3 2e-42 144.5 6.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DHHC PF01529.20 EAZ51489.1 - 4.6e-32 110.9 8.3 7.1e-32 110.3 8.3 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase UPF0542 PF15086.6 EAZ51489.1 - 0.066 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 CbiX PF01903.17 EAZ51489.1 - 0.086 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 CbiX Sedlin_N PF04628.13 EAZ51490.1 - 7.9e-37 126.3 0.0 9.1e-37 126.1 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EAZ51490.1 - 1.3e-05 25.1 0.0 1.7e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Sybindin-like family Pkinase PF00069.25 EAZ51491.1 - 3.8e-57 193.6 0.0 5e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51491.1 - 9.4e-40 136.5 0.0 2.1e-39 135.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51491.1 - 3.6e-08 33.1 0.0 5.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51491.1 - 2.9e-06 26.3 0.1 4.1e-06 25.8 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EAZ51491.1 - 0.012 14.6 0.2 0.022 13.7 0.2 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EAZ51491.1 - 0.096 12.0 0.1 0.23 10.8 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Saf_2TM PF18303.1 EAZ51491.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Pkinase PF00069.25 EAZ51492.1 - 4.8e-56 190.1 4.2 4.8e-56 190.1 4.2 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51492.1 - 3.7e-30 105.1 0.3 7.4e-29 100.8 0.1 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 EAZ51492.1 - 1.9e-05 24.3 0.1 4.2e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EAZ51492.1 - 0.0086 15.5 0.6 0.016 14.6 0.6 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EAZ51492.1 - 0.012 15.0 0.0 0.024 13.9 0.0 1.6 1 1 0 1 1 1 0 Kinase-like ABC_tran_2 PF16949.5 EAZ51492.1 - 0.23 10.2 0.0 0.31 9.8 0.0 1.1 1 0 0 1 1 1 0 Putative ATP-binding cassette APH PF01636.23 EAZ51492.1 - 0.29 11.0 0.0 0.48 10.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Acatn PF13000.7 EAZ51493.1 - 1.8e-95 320.6 18.9 3.2e-95 319.7 18.8 1.5 1 1 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Atg14 PF10186.9 EAZ51494.1 - 0.0009 18.4 2.9 0.0009 18.4 2.9 2.2 1 1 1 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4795 PF16043.5 EAZ51494.1 - 0.014 15.0 7.6 0.019 14.6 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) ATP-synt_ab PF00006.25 EAZ51495.1 - 1.4e-65 221.0 0.0 2e-65 220.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EAZ51495.1 - 1.6e-13 50.9 0.8 3.3e-13 49.9 0.8 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab_C PF00306.27 EAZ51495.1 - 4.1e-11 43.3 6.4 8.3e-11 42.3 6.4 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain Roc PF08477.13 EAZ51495.1 - 0.11 12.7 0.1 1.2 9.3 0.0 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EAZ51495.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.4 3 1 0 3 3 3 0 AAA domain Pkinase PF00069.25 EAZ51496.1 - 1e-60 205.4 0.0 1.2e-60 205.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51496.1 - 1.3e-19 70.5 0.0 1.7e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EAZ51496.1 - 6.8e-07 29.4 0.0 8.2e-06 25.9 0.0 2.4 1 1 2 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EAZ51496.1 - 0.011 15.3 0.7 0.075 12.6 0.1 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 EAZ51496.1 - 0.034 13.5 0.1 0.055 12.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EAZ51496.1 - 0.036 12.8 0.0 0.05 12.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 EAZ51497.1 - 3.2e-76 256.2 0.0 7.7e-76 254.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51497.1 - 1.3e-41 142.7 0.0 2.2e-41 141.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51497.1 - 1.2e-06 28.1 0.0 5.2e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EAZ51497.1 - 0.022 14.7 0.1 0.037 13.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EAZ51497.1 - 0.077 12.3 0.0 0.21 10.9 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribonuc_red_sm PF00268.21 EAZ51498.1 - 1.6e-45 155.7 13.6 3.4e-45 154.7 13.6 1.5 1 1 0 1 1 1 1 Ribonucleotide reductase, small chain Hemocyanin_N PF03722.14 EAZ51498.1 - 0.0067 16.9 3.6 3.5 8.2 1.8 2.5 2 0 0 2 2 2 2 Hemocyanin, all-alpha domain DUF2290 PF10053.9 EAZ51498.1 - 0.098 12.1 2.8 0.21 11.0 0.1 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2290) E1-E2_ATPase PF00122.20 EAZ51499.1 - 4.2e-17 62.2 0.1 2.2e-06 27.3 0.1 3.6 3 0 0 3 3 3 3 E1-E2 ATPase Hydrolase PF00702.26 EAZ51499.1 - 4.2e-09 37.0 0.0 0.051 13.8 0.0 3.9 4 0 0 4 4 4 3 haloacid dehalogenase-like hydrolase LRR_4 PF12799.7 EAZ51500.1 - 7.5e-29 99.3 60.2 2.9e-08 33.9 6.3 7.1 3 1 6 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EAZ51500.1 - 1.5e-21 76.7 31.3 1.9e-07 30.8 1.7 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 EAZ51500.1 - 1.2e-19 69.8 48.2 6.9e-09 35.4 2.3 6.9 2 1 6 8 8 8 8 Leucine rich repeat LRR_1 PF00560.33 EAZ51500.1 - 0.0066 16.8 39.5 3.2 8.7 0.0 10.0 10 1 0 10 10 10 3 Leucine Rich Repeat Latarcin PF10279.9 EAZ51500.1 - 0.01 16.2 0.0 1.1 9.7 0.0 3.0 1 1 0 1 1 1 0 Latarcin precursor LRR_6 PF13516.6 EAZ51500.1 - 0.05 13.7 32.3 1 9.6 0.2 9.0 10 0 0 10 10 10 0 Leucine Rich repeat IGR PF09597.10 EAZ51500.1 - 0.31 11.2 1.6 9.9 6.4 0.1 3.6 2 1 2 4 4 4 0 IGR protein motif LRR_2 PF07723.13 EAZ51500.1 - 0.43 11.3 5.9 30 5.5 0.2 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat AAA PF00004.29 EAZ51501.1 - 5.5e-43 146.5 0.0 1.1e-42 145.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EAZ51501.1 - 3.2e-11 42.8 0.1 7.7e-11 41.6 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EAZ51501.1 - 2.1e-07 31.2 0.0 5.2e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EAZ51501.1 - 5.4e-06 26.5 0.0 1.8e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EAZ51501.1 - 1e-05 25.8 0.8 0.0056 16.9 0.8 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EAZ51501.1 - 1.2e-05 25.8 0.2 0.00011 22.6 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EAZ51501.1 - 0.0001 22.1 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EAZ51501.1 - 0.00068 18.9 0.1 0.0024 17.1 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 EAZ51501.1 - 0.0011 19.1 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EAZ51501.1 - 0.0017 18.9 0.1 0.012 16.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EAZ51501.1 - 0.0027 17.5 0.0 0.0056 16.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase PF06745.13 EAZ51501.1 - 0.0037 16.7 1.1 0.022 14.1 0.0 2.5 3 0 0 3 3 3 1 KaiC Mg_chelatase PF01078.21 EAZ51501.1 - 0.0075 15.7 0.1 0.018 14.4 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EAZ51501.1 - 0.0082 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EAZ51501.1 - 0.011 16.0 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EAZ51501.1 - 0.014 15.8 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EAZ51501.1 - 0.015 15.3 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 EAZ51501.1 - 0.016 14.6 0.1 0.15 11.5 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein DUF4200 PF13863.6 EAZ51501.1 - 0.019 15.4 0.4 0.036 14.4 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) NACHT PF05729.12 EAZ51501.1 - 0.019 14.9 0.0 0.68 9.8 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_14 PF13173.6 EAZ51501.1 - 0.025 14.6 0.0 0.066 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EAZ51501.1 - 0.026 14.2 0.1 0.066 12.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EAZ51501.1 - 0.031 14.0 1.2 0.12 12.0 0.0 2.5 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_7 PF12775.7 EAZ51501.1 - 0.033 13.7 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EAZ51501.1 - 0.045 13.3 0.1 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EAZ51501.1 - 0.047 12.8 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF815 PF05673.13 EAZ51501.1 - 0.061 12.5 0.0 0.16 11.1 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF815) AAA_17 PF13207.6 EAZ51501.1 - 0.086 13.3 0.1 0.28 11.6 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.6 EAZ51501.1 - 0.11 12.3 0.2 0.37 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EAZ51501.1 - 0.13 11.5 0.0 0.28 10.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin RILP PF11461.8 EAZ51501.1 - 0.13 12.5 1.0 0.31 11.3 1.0 1.6 1 0 0 1 1 1 0 Rab interacting lysosomal protein Phage_GP20 PF06810.11 EAZ51501.1 - 0.14 12.0 0.9 14 5.4 0.2 2.5 2 0 0 2 2 2 0 Phage minor structural protein GP20 Pkinase PF00069.25 EAZ51502.1 - 3.3e-30 105.3 0.0 3.8e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51502.1 - 1.3e-14 54.1 0.0 1.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EAZ51502.1 - 5.2e-06 25.5 0.0 6.7e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EAZ51502.1 - 2.6e-05 23.7 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EAZ51502.1 - 0.0016 17.8 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DnaJ PF00226.31 EAZ51503.1 - 2.9e-22 78.5 1.2 2.9e-22 78.5 1.2 2.7 2 0 0 2 2 2 1 DnaJ domain IFRD PF05004.13 EAZ51503.1 - 0.03 13.4 3.8 0.027 13.6 2.2 1.7 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) Ribosom_S12_S23 PF00164.25 EAZ51504.1 - 5.5e-50 167.8 0.5 7.2e-50 167.4 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Methyltransf_15 PF09445.10 EAZ51504.1 - 0.0018 17.9 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase HA2 PF04408.23 EAZ51505.1 - 7.4e-25 87.3 0.0 2.4e-24 85.7 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EAZ51505.1 - 9.7e-25 86.8 0.0 2.1e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EAZ51505.1 - 5.9e-12 45.9 0.0 3.6e-11 43.4 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EAZ51505.1 - 2e-07 31.0 0.1 4.1e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EAZ51505.1 - 9.3e-07 29.2 0.0 3.2e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EAZ51505.1 - 0.00034 21.0 0.0 0.00074 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EAZ51505.1 - 0.008 15.9 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EAZ51505.1 - 0.0086 15.2 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA PF00004.29 EAZ51505.1 - 0.012 16.1 0.5 1.5 9.2 0.0 3.9 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EAZ51505.1 - 0.016 14.5 0.1 0.042 13.2 0.0 1.6 2 0 0 2 2 2 0 KaiC PhoH PF02562.16 EAZ51505.1 - 0.021 14.3 0.0 0.068 12.6 0.0 1.9 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 EAZ51505.1 - 0.073 13.1 0.3 4.1 7.5 0.3 2.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EAZ51505.1 - 0.079 13.5 4.1 0.72 10.4 0.2 3.5 3 1 0 4 4 4 0 ABC transporter Microtub_bd PF16796.5 EAZ51505.1 - 0.096 12.6 0.0 5.9 6.8 0.0 2.7 2 0 0 2 2 2 0 Microtubule binding Pkinase PF00069.25 EAZ51506.1 - 2.6e-61 207.3 0.0 7.7e-61 205.8 0.0 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51506.1 - 3.3e-28 98.7 0.0 1.1e-27 96.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Trypan_PARP PF05887.11 EAZ51506.1 - 0.12 12.3 5.9 0.22 11.5 5.9 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) EMC3_TMCO1 PF01956.16 EAZ51507.1 - 3.9e-16 59.3 3.4 4.6e-16 59.0 3.4 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DUF4229 PF14012.6 EAZ51507.1 - 0.033 14.3 0.4 0.42 10.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) SRPRB PF09439.10 EAZ51508.1 - 8.9e-20 70.9 1.0 2.2e-19 69.6 1.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EAZ51508.1 - 2.9e-12 46.4 0.2 8.2e-12 44.9 0.2 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51508.1 - 1.4e-06 28.3 0.4 2.9e-06 27.4 0.4 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EAZ51508.1 - 5.9e-06 25.8 0.5 1e-05 25.1 0.5 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EAZ51508.1 - 0.00052 20.0 3.4 0.071 13.0 0.3 3.0 1 1 2 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 EAZ51508.1 - 0.0019 18.4 0.1 0.0047 17.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EAZ51508.1 - 0.0028 17.4 0.9 0.0053 16.5 0.2 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 EAZ51508.1 - 0.0052 17.0 1.0 0.04 14.1 1.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EAZ51508.1 - 0.0077 15.8 2.5 0.1 12.2 0.2 2.1 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EAZ51508.1 - 0.01 15.8 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 EAZ51508.1 - 0.017 14.9 0.2 0.031 14.0 0.2 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 EAZ51508.1 - 0.022 14.0 0.2 0.035 13.3 0.2 1.5 1 1 0 1 1 1 0 NB-ARC domain Ras PF00071.22 EAZ51508.1 - 0.029 14.0 2.6 0.38 10.3 2.6 2.4 1 1 0 1 1 1 0 Ras family AAA_23 PF13476.6 EAZ51508.1 - 0.034 14.6 5.7 0.82 10.1 5.7 2.1 1 1 0 1 1 1 0 AAA domain DUF3987 PF13148.6 EAZ51508.1 - 0.041 12.9 0.0 0.062 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) AAA_16 PF13191.6 EAZ51508.1 - 0.046 14.1 0.2 0.12 12.8 0.1 1.6 1 1 1 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EAZ51508.1 - 0.047 13.4 0.2 0.071 12.8 0.2 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EAZ51508.1 - 0.051 13.5 0.2 0.31 10.9 0.1 2.0 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EAZ51508.1 - 0.052 13.7 0.3 0.068 13.3 0.3 1.3 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EAZ51508.1 - 0.054 13.2 1.1 0.067 12.9 1.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EAZ51508.1 - 0.06 12.8 0.4 0.1 12.1 0.1 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 EAZ51508.1 - 0.088 13.2 0.3 0.18 12.3 0.3 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EAZ51508.1 - 0.094 12.5 0.1 0.11 12.2 0.1 1.3 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EAZ51508.1 - 0.098 12.4 1.3 0.64 9.7 0.5 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ResIII PF04851.15 EAZ51508.1 - 0.14 12.2 2.1 0.39 10.7 2.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EAZ51508.1 - 0.18 12.2 1.9 0.66 10.4 1.2 2.3 1 1 1 2 2 2 0 RNA helicase NTPase_1 PF03266.15 EAZ51508.1 - 0.19 11.6 1.4 0.66 9.9 0.4 2.0 1 1 2 3 3 3 0 NTPase ABC_tran PF00005.27 EAZ51508.1 - 0.28 11.7 4.3 0.46 11.0 4.3 1.5 1 1 0 1 1 1 0 ABC transporter SMC_N PF02463.19 EAZ51508.1 - 0.46 9.9 1.9 1.5 8.2 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Ribosomal_L28e PF01778.17 EAZ51509.1 - 1.7e-31 109.4 1.0 1.7e-31 109.4 1.0 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EAZ51509.1 - 6e-22 78.1 8.9 1.1e-21 77.3 8.9 1.5 1 1 0 1 1 1 1 Mak16 protein C-terminal region ANAPC10 PF03256.16 EAZ51510.1 - 2.9e-45 154.2 0.0 3.5e-45 153.9 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 EAZ51510.1 - 0.00052 20.1 0.0 0.00061 19.9 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain DUF1764 PF08576.10 EAZ51511.1 - 8.3e-07 29.8 1.1 1.2e-06 29.4 1.1 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Kinesin PF00225.23 EAZ51512.1 - 4.5e-65 219.8 0.6 4.5e-65 219.8 0.6 2.6 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EAZ51512.1 - 1.3e-17 64.1 0.6 3.6e-17 62.7 0.6 1.8 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 EAZ51513.1 - 1.7e-94 316.5 7.0 1.7e-94 316.5 7.0 2.8 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EAZ51513.1 - 2.2e-22 79.6 1.1 2.2e-22 79.6 1.1 3.4 3 1 1 4 4 4 1 Microtubule binding BT1 PF03092.16 EAZ51514.1 - 1.5e-08 33.3 0.2 2.2e-08 32.8 0.2 1.3 1 0 0 1 1 1 1 BT1 family DUF3433 PF11915.8 EAZ51514.1 - 0.0066 16.9 1.2 0.012 16.1 1.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3433) PUCC PF03209.15 EAZ51514.1 - 0.037 13.1 0.9 4.1 6.3 0.2 2.2 2 0 0 2 2 2 0 PUCC protein Ion_trans_2 PF07885.16 EAZ51515.1 - 1.7e-13 50.3 0.1 7.8e-13 48.2 0.1 2.1 1 0 0 1 1 1 1 Ion channel BK_channel_a PF03493.18 EAZ51515.1 - 2.3e-05 24.5 0.0 8.9e-05 22.6 0.0 2.1 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit RRM_1 PF00076.22 EAZ51516.1 - 1.1e-10 41.2 0.6 3.6e-07 29.9 0.1 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EAZ51516.1 - 2.3e-05 24.0 1.7 0.0001 21.9 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 EAZ51516.1 - 0.004 17.0 0.1 0.0082 16.0 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1866) DUF4523 PF15023.6 EAZ51516.1 - 0.015 15.2 0.1 0.025 14.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Myb_DNA-binding PF00249.31 EAZ51517.1 - 6.2e-23 80.7 4.7 4.4e-11 42.8 0.3 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EAZ51517.1 - 2.3e-18 66.2 2.2 1.1e-13 51.2 0.2 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EAZ51517.1 - 0.016 15.1 0.4 13 5.8 0.0 3.4 3 0 0 3 3 3 0 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 EAZ51517.1 - 0.021 15.2 0.3 0.68 10.4 0.0 2.9 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Topoisom_bac PF01131.20 EAZ51518.1 - 8.6e-113 377.4 0.0 1.2e-112 377.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EAZ51518.1 - 6.9e-17 61.6 0.0 1.7e-16 60.3 0.0 1.8 1 0 0 1 1 1 1 Toprim domain PHF5 PF03660.14 EAZ51519.1 - 1.9e-44 150.1 13.9 2e-44 150.0 13.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EAZ51519.1 - 0.19 9.6 8.4 0.2 9.5 8.4 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EAZ51519.1 - 0.37 10.9 15.9 2.1 8.4 2.7 2.7 1 1 1 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 EAZ51519.1 - 7.6 6.9 19.6 0.36 11.2 6.2 3.0 1 1 1 2 2 2 0 C1 domain DUF2039 PF10217.9 EAZ51519.1 - 9.4 6.7 16.6 1.4e+02 2.9 16.6 2.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) HECT PF00632.25 EAZ51520.1 - 1.6e-87 293.9 0.3 3.1e-87 292.9 0.1 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) IPPT PF01715.17 EAZ51521.1 - 2.7e-54 184.4 0.1 3.6e-54 184.0 0.1 1.1 1 0 0 1 1 1 1 IPP transferase DnaJ PF00226.31 EAZ51522.1 - 1.3e-29 102.1 3.8 2e-29 101.5 3.8 1.3 1 0 0 1 1 1 1 DnaJ domain NCOA_u2 PF16665.5 EAZ51522.1 - 1.5 9.1 12.1 0.14 12.5 7.1 1.7 2 0 0 2 2 2 0 Unstructured region on nuclear receptor coactivator protein OTU PF02338.19 EAZ51523.1 - 6.8e-15 55.7 0.1 2.6e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EAZ51523.1 - 1.2e-08 34.7 2.4 2.5e-05 23.9 1.2 2.5 2 0 0 2 2 2 2 Peptidase C65 Otubain RCC1 PF00415.18 EAZ51524.1 - 3e-76 251.9 20.0 8.8e-15 55.1 0.4 7.2 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EAZ51524.1 - 5.8e-36 121.6 42.0 4.7e-08 32.6 0.2 8.2 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.14 EAZ51524.1 - 0.0041 16.9 3.3 2.5 8.0 0.0 4.2 4 1 1 5 5 5 2 Peptidase family C25, C terminal ig-like domain Hira PF07569.11 EAZ51524.1 - 0.032 14.0 0.6 14 5.3 0.0 3.9 4 0 0 4 4 4 0 TUP1-like enhancer of split Cep57_CLD_2 PF14197.6 EAZ51524.1 - 0.22 11.6 3.9 0.52 10.4 3.9 1.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Kinesin PF00225.23 EAZ51525.1 - 2.7e-107 358.6 1.9 2.7e-107 358.6 1.9 2.8 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EAZ51525.1 - 1.5e-24 86.7 0.1 1.5e-24 86.7 0.1 2.8 2 1 1 3 3 3 1 Microtubule binding APG6_N PF17675.1 EAZ51525.1 - 7.4 7.1 62.8 1.4 9.5 20.2 4.4 1 1 2 3 3 3 0 Apg6 coiled-coil region Gtr1_RagA PF04670.12 EAZ51526.1 - 1.9e-83 279.4 0.5 2.6e-83 278.9 0.5 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EAZ51526.1 - 1.4e-06 28.5 0.1 1e-05 25.8 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EAZ51526.1 - 7.5e-06 25.6 0.6 2.9e-05 23.7 0.0 2.1 2 1 0 2 2 2 1 Ras family Arf PF00025.21 EAZ51526.1 - 2e-05 24.1 0.0 3.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51526.1 - 0.00037 20.6 0.0 0.0014 18.6 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EAZ51526.1 - 0.017 15.6 0.0 0.042 14.4 0.0 1.9 1 1 0 1 1 1 0 ABC transporter Fer2 PF00111.27 EAZ51527.1 - 1.5e-12 47.3 0.7 1.9e-12 47.0 0.7 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain RRM_1 PF00076.22 EAZ51528.1 - 1.6e-75 248.9 0.1 6.8e-19 67.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EAZ51528.1 - 3.6e-26 91.1 0.9 8e-26 90.0 0.9 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EAZ51528.1 - 6.1e-06 25.8 0.7 0.0069 16.0 0.0 4.3 3 1 2 5 5 5 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EAZ51528.1 - 0.00097 19.0 0.0 0.14 12.0 0.0 3.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EAZ51528.1 - 0.0012 18.9 0.0 14 5.9 0.0 4.6 4 1 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EAZ51528.1 - 0.0036 17.3 0.1 7.2 6.7 0.0 3.9 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EAZ51528.1 - 0.014 15.4 0.1 7.7 6.6 0.0 3.6 3 0 0 3 3 3 0 RNA binding motif CDC45 PF02724.14 EAZ51528.1 - 0.38 9.0 5.9 0.53 8.5 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EAZ51528.1 - 0.75 8.5 5.3 1.3 7.7 5.3 1.3 1 0 0 1 1 1 0 Presenilin Ribosomal_L4 PF00573.22 EAZ51529.1 - 2e-40 138.6 0.1 2e-40 138.6 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EAZ51529.1 - 3.5e-18 65.4 0.6 9.8e-18 64.0 0.1 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Pkinase PF00069.25 EAZ51530.1 - 1.8e-65 221.0 0.0 5.2e-65 219.4 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51530.1 - 2.4e-33 115.5 0.0 3.8e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51530.1 - 3.9e-07 29.7 0.0 7.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51530.1 - 4.8e-05 22.3 0.0 0.00015 20.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EAZ51530.1 - 0.0026 17.1 0.0 0.0064 15.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EAZ51530.1 - 0.037 13.6 0.1 0.084 12.5 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Collagen PF01391.18 EAZ51531.1 - 3.2 7.6 9.0 45 3.9 9.0 2.4 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Peptidase_M22 PF00814.25 EAZ51532.1 - 1.8e-79 267.2 0.0 2.3e-79 266.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family WD40 PF00400.32 EAZ51533.1 - 6.5e-30 102.8 20.0 2.5e-07 31.3 0.2 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51533.1 - 7.7e-16 58.2 0.0 0.02 15.2 0.0 4.9 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EAZ51533.1 - 1.9e-06 27.4 0.0 1.2 8.4 0.0 4.5 3 2 1 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 EAZ51533.1 - 0.00017 20.7 0.0 0.84 8.5 0.0 3.5 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EAZ51533.1 - 0.05 12.3 0.0 0.13 10.9 0.0 1.5 2 0 0 2 2 2 0 Nucleoporin Nup120/160 eIF2A PF08662.11 EAZ51533.1 - 0.082 12.8 0.1 89 2.9 0.0 3.5 2 2 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A TRAPP PF04051.16 EAZ51534.1 - 1.1e-36 125.7 0.0 1.3e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ras PF00071.22 EAZ51535.1 - 4.5e-60 201.9 1.7 5.3e-60 201.7 1.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51535.1 - 1.9e-34 118.5 1.4 2.8e-34 117.9 0.2 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51535.1 - 1.9e-13 50.2 0.4 2.5e-13 49.9 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51535.1 - 5.3e-06 26.5 0.1 9.3e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAZ51535.1 - 7.5e-06 26.0 0.6 0.063 13.2 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EAZ51535.1 - 3.7e-05 23.2 0.5 4.6e-05 22.9 0.5 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EAZ51535.1 - 9.5e-05 22.0 0.6 0.00023 20.8 0.6 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EAZ51535.1 - 0.0084 16.4 0.0 0.12 12.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EAZ51535.1 - 0.017 15.6 0.0 0.025 15.1 0.0 1.4 1 1 0 1 1 1 0 ABC transporter DUF1327 PF07041.11 EAZ51535.1 - 0.035 14.1 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1327) AAA_16 PF13191.6 EAZ51535.1 - 0.087 13.2 0.0 0.13 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EAZ51535.1 - 0.13 12.4 0.0 0.51 10.5 0.0 1.7 1 1 0 2 2 2 0 AAA domain SNF2_N PF00176.23 EAZ51536.1 - 5.2e-67 226.0 0.0 1e-66 225.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EAZ51536.1 - 3.1e-31 107.8 7.4 1.7e-30 105.4 4.0 3.1 2 0 0 2 2 2 1 SLIDE Helicase_C PF00271.31 EAZ51536.1 - 5.2e-19 68.6 0.0 3.4e-18 66.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EAZ51536.1 - 2.5e-13 50.4 0.0 1.2e-11 44.9 0.0 3.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EAZ51536.1 - 5.4e-06 26.3 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EAZ51536.1 - 0.00019 20.7 0.1 0.032 13.4 0.0 2.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DEAD_2 PF06733.15 EAZ51536.1 - 0.0016 18.1 0.0 0.0047 16.6 0.0 1.8 1 0 0 1 1 1 1 DEAD_2 AAA_14 PF13173.6 EAZ51536.1 - 0.047 13.7 0.2 0.32 11.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EAZ51536.1 - 0.13 12.6 0.1 0.62 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 EAZ51537.1 - 1.1e-53 181.7 0.2 2.1e-53 180.8 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EAZ51537.1 - 2.6e-15 56.2 0.0 8.4e-15 54.6 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EAZ51537.1 - 1.1e-06 28.6 0.0 4e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EAZ51537.1 - 5.3e-05 23.3 0.1 0.00018 21.5 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_IV PF03764.18 EAZ51537.1 - 0.00032 20.5 0.0 0.001 18.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 EAZ51537.1 - 0.034 14.5 0.0 0.086 13.2 0.0 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 EAZ51538.1 - 1.4e-52 178.1 0.0 2.1e-52 177.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EAZ51538.1 - 9.4e-41 138.6 0.1 2.6e-40 137.2 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EAZ51538.1 - 3.6e-16 59.3 0.5 1.7e-15 57.1 0.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EAZ51538.1 - 9.4e-05 22.5 0.0 0.0035 17.4 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EAZ51538.1 - 0.0013 18.6 0.3 0.0043 16.9 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 FlpD PF02662.16 EAZ51538.1 - 0.024 14.6 0.1 0.091 12.8 0.0 1.9 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit G-alpha PF00503.20 EAZ51538.1 - 0.19 10.8 0.2 0.88 8.7 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit PDEase_I PF00233.19 EAZ51539.1 - 3.3e-45 154.7 13.4 2.7e-44 151.7 13.4 2.6 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Wzy_C PF04932.15 EAZ51539.1 - 0.054 13.1 0.1 9.8 5.8 0.1 2.5 2 1 0 2 2 2 0 O-Antigen ligase DUF420 PF04238.12 EAZ51539.1 - 0.61 10.4 4.1 4 7.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF420) FH2 PF02181.23 EAZ51540.1 - 3.2e-76 256.9 0.2 5.4e-76 256.1 0.2 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain TPR_10 PF13374.6 EAZ51540.1 - 3.3e-10 39.5 0.4 0.032 14.1 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EAZ51540.1 - 1.2e-09 38.4 0.1 5.5e-06 26.6 0.0 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EAZ51540.1 - 0.0092 15.8 8.5 4.6 7.2 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF4167 PF13763.6 EAZ51540.1 - 0.0099 16.0 0.0 0.028 14.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4167) TPR_2 PF07719.17 EAZ51540.1 - 0.021 14.9 7.1 3.5 8.0 0.6 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinesin PF00225.23 EAZ51541.1 - 8.1e-110 366.9 2.6 8.1e-110 366.9 2.6 2.7 4 1 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EAZ51541.1 - 1.4e-24 86.7 0.2 1.4e-24 86.7 0.2 3.2 2 0 0 2 2 2 1 Microtubule binding UDPGT PF00201.18 EAZ51541.1 - 0.0016 17.3 0.9 0.0016 17.3 0.9 2.2 2 1 1 3 3 3 1 UDP-glucoronosyl and UDP-glucosyl transferase ResIII PF04851.15 EAZ51541.1 - 0.24 11.4 0.0 0.24 11.4 0.0 4.1 4 1 0 4 4 4 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EAZ51541.1 - 0.39 11.0 0.0 0.39 11.0 0.0 3.2 3 1 1 4 4 4 0 AAA domain VASP_tetra PF08776.11 EAZ51541.1 - 0.77 9.4 4.4 3.6 7.2 4.4 2.2 1 0 0 1 1 1 0 VASP tetramerisation domain DUF4208 PF13907.6 EAZ51541.1 - 0.8 10.2 6.1 14 6.2 0.0 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF4208) DUF4140 PF13600.6 EAZ51541.1 - 8.6 6.9 6.2 3.2 8.2 0.0 3.4 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Myosin_head PF00063.21 EAZ51542.1 - 7e-209 695.4 1.3 2e-208 693.9 1.3 1.8 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.19 EAZ51542.1 - 0.00047 19.9 0.0 0.0012 18.6 0.0 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Uso1_p115_C PF04871.13 EAZ51542.1 - 0.0023 18.3 6.6 0.0023 18.3 6.6 5.2 2 2 2 4 4 4 1 Uso1 / p115 like vesicle tethering protein, C terminal region IQ PF00612.27 EAZ51542.1 - 0.017 14.8 16.8 0.17 11.8 0.2 4.1 4 0 0 4 4 4 0 IQ calmodulin-binding motif CbiA PF01656.23 EAZ51542.1 - 0.073 13.1 0.7 0.3 11.2 0.0 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Spc7 PF08317.11 EAZ51542.1 - 0.24 10.3 62.7 0.025 13.4 11.6 3.5 2 1 1 3 3 3 0 Spc7 kinetochore protein AAA_22 PF13401.6 EAZ51542.1 - 0.53 10.6 0.0 0.53 10.6 0.0 4.0 4 0 0 4 4 4 0 AAA domain AAA_16 PF13191.6 EAZ51542.1 - 1.6 9.1 0.0 1.6 9.1 0.0 3.5 4 0 0 4 4 4 0 AAA ATPase domain CALCOCO1 PF07888.11 EAZ51542.1 - 3.4 6.4 57.9 0.8 8.5 13.1 2.4 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2407_C PF13373.6 EAZ51542.1 - 6.7 6.9 7.2 25 5.0 7.2 2.0 1 0 0 1 1 1 0 DUF2407 C-terminal domain Ank_2 PF12796.7 EAZ51543.1 - 2.8e-23 82.3 0.1 4.2e-12 46.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EAZ51543.1 - 8.8e-23 80.4 0.3 6.7e-07 29.7 0.0 4.7 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EAZ51543.1 - 3.8e-19 68.5 0.6 4.6e-08 33.2 0.0 4.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EAZ51543.1 - 1.1e-16 60.4 1.1 0.00052 20.3 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EAZ51543.1 - 1.4e-14 52.8 0.1 0.004 17.5 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat WD40 PF00400.32 EAZ51544.1 - 2e-18 66.4 11.1 0.00015 22.5 0.4 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.11 EAZ51544.1 - 0.00032 20.6 0.0 0.31 10.9 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EAZ51544.1 - 0.00034 20.9 0.0 18 5.7 0.0 4.8 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EAZ51544.1 - 0.082 11.4 0.0 0.27 9.7 0.0 1.7 2 0 0 2 2 2 0 Cytochrome D1 heme domain ABC_membrane PF00664.23 EAZ51545.1 - 3.2e-89 299.2 30.3 1.7e-47 162.4 12.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EAZ51545.1 - 1.5e-49 168.1 0.6 1.1e-33 116.7 0.2 2.9 2 0 0 2 2 2 2 ABC transporter AAA_15 PF13175.6 EAZ51545.1 - 1.4e-09 38.2 8.7 7.3e-06 25.9 0.1 3.3 3 1 0 3 3 2 2 AAA ATPase domain SMC_N PF02463.19 EAZ51545.1 - 1.1e-07 31.6 3.2 0.0068 15.9 1.6 3.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EAZ51545.1 - 2.7e-07 30.7 5.4 0.037 13.8 0.1 3.6 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EAZ51545.1 - 5.1e-07 29.3 0.9 0.015 15.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EAZ51545.1 - 1.7e-06 28.0 0.1 0.031 14.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EAZ51545.1 - 2.9e-06 27.8 0.0 0.079 13.3 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EAZ51545.1 - 5.2e-06 26.8 0.3 0.12 12.6 0.0 3.3 2 1 0 2 2 2 2 AAA domain G-alpha PF00503.20 EAZ51545.1 - 4.3e-05 22.8 0.5 0.042 13.0 0.0 2.6 2 0 0 2 2 2 2 G-protein alpha subunit AAA_23 PF13476.6 EAZ51545.1 - 0.00015 22.4 7.1 0.12 12.8 0.4 3.4 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EAZ51545.1 - 0.00025 21.1 0.0 0.078 13.1 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EAZ51545.1 - 0.00035 20.4 0.0 0.88 9.3 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EAZ51545.1 - 0.002 17.7 0.0 1.3 8.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region Ycf70 PF17382.2 EAZ51545.1 - 0.0091 16.4 0.2 0.05 14.0 0.2 2.3 1 0 0 1 1 1 1 Uncharacterized Ycf70-like AAA_18 PF13238.6 EAZ51545.1 - 0.01 16.4 0.0 0.46 11.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EAZ51545.1 - 0.012 15.6 0.0 11 6.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EAZ51545.1 - 0.013 15.6 0.4 3.2 7.8 0.0 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain DUF417 PF04224.12 EAZ51545.1 - 0.021 14.4 0.9 0.12 11.9 0.4 2.6 3 0 0 3 3 2 0 Protein of unknown function, DUF417 DUF815 PF05673.13 EAZ51545.1 - 0.024 13.8 0.1 0.1 11.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 EAZ51545.1 - 0.043 13.1 0.0 4.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.12 EAZ51545.1 - 0.05 13.5 0.1 9.6 6.1 0.0 2.9 3 0 0 3 3 2 0 NACHT domain RNA_helicase PF00910.22 EAZ51545.1 - 0.065 13.6 0.0 12 6.4 0.0 3.1 2 0 0 2 2 2 0 RNA helicase ATP-synt_ab PF00006.25 EAZ51545.1 - 0.072 12.7 0.0 0.45 10.1 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 EAZ51545.1 - 0.081 13.4 0.2 18 5.7 0.4 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 EAZ51545.1 - 0.087 12.6 0.0 6.6 6.4 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family YjzC PF14168.6 EAZ51547.1 - 0.22 11.9 1.2 3.1 8.2 0.0 2.8 2 0 0 2 2 2 0 YjzC-like protein TolA_bind_tri PF16331.5 EAZ51547.1 - 4.1 7.6 31.0 2.2 8.4 10.2 5.3 4 1 0 4 4 4 0 TolA binding protein trimerisation DUF4140 PF13600.6 EAZ51547.1 - 4.6 7.7 23.3 0.069 13.6 2.4 4.6 3 2 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) Filament PF00038.21 EAZ51547.1 - 6 6.4 51.9 0.027 14.0 26.0 3.1 2 1 1 3 3 3 0 Intermediate filament protein SLED PF12140.8 EAZ51547.1 - 6.2 7.4 9.9 1.9 9.0 0.2 3.9 3 1 0 3 3 3 0 SLED domain SlyX PF04102.12 EAZ51547.1 - 6.6 7.4 32.0 1.5 9.5 0.3 5.3 4 1 1 5 5 5 0 SlyX Lebercilin PF15619.6 EAZ51547.1 - 8.6 6.0 47.8 0.17 11.5 16.5 4.3 3 1 1 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Acylphosphatase PF00708.18 EAZ51548.1 - 8.4e-21 74.2 0.1 1.1e-20 73.8 0.1 1.1 1 0 0 1 1 1 1 Acylphosphatase Pkinase PF00069.25 EAZ51549.1 - 1.2e-32 113.4 3.6 4.5e-15 55.7 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51549.1 - 5e-15 55.5 0.5 6.9e-08 32.1 0.6 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51549.1 - 7.5e-06 25.5 0.0 0.11 11.8 0.1 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EAZ51549.1 - 0.046 12.5 0.2 0.069 11.9 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase Tfb4 PF03850.14 EAZ51550.1 - 3.2e-28 99.0 5.7 5.8e-28 98.1 5.4 1.7 1 1 0 1 1 1 1 Transcription factor Tfb4 Mannosyl_trans2 PF04188.13 EAZ51551.1 - 2.9e-35 122.4 49.9 4.2e-35 121.9 49.9 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) ABC2_membrane PF01061.24 EAZ51552.1 - 5.5e-34 117.4 21.0 5.5e-34 117.4 21.0 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EAZ51552.1 - 9.8e-24 84.4 0.0 1.7e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EAZ51552.1 - 8.9e-08 31.6 23.9 8.9e-08 31.6 23.9 1.9 2 1 0 2 2 2 1 ABC-2 family transporter protein SMC_N PF02463.19 EAZ51552.1 - 2.6e-06 27.1 0.4 0.0086 15.5 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EAZ51552.1 - 1.6e-05 24.9 3.6 0.072 12.9 0.1 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EAZ51552.1 - 0.00037 20.4 0.1 0.00088 19.2 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EAZ51552.1 - 0.00044 19.9 0.1 0.00099 18.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EAZ51552.1 - 0.0011 19.1 0.2 0.0026 17.8 0.2 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EAZ51552.1 - 0.0014 19.2 0.2 0.0034 17.9 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EAZ51552.1 - 0.0018 18.8 0.0 0.0035 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EAZ51552.1 - 0.0031 17.9 0.1 0.0085 16.5 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 EAZ51552.1 - 0.019 14.8 0.1 0.035 14.0 0.1 1.4 1 0 0 1 1 1 0 NTPase T2SSE PF00437.20 EAZ51552.1 - 0.023 13.7 0.1 0.039 13.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EAZ51552.1 - 0.028 14.7 0.1 0.071 13.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 EAZ51552.1 - 0.029 13.3 0.1 0.049 12.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IglC PF11550.8 EAZ51552.1 - 0.042 13.3 0.4 0.081 12.4 0.4 1.4 1 0 0 1 1 1 0 Intracellular growth locus C protein AAA PF00004.29 EAZ51552.1 - 0.058 13.8 0.1 0.32 11.4 0.0 2.2 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 EAZ51552.1 - 0.07 13.2 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Dynamin family Rad17 PF03215.15 EAZ51552.1 - 0.087 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 EAZ51552.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EAZ51552.1 - 0.11 12.8 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EAZ51552.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EAZ51552.1 - 0.16 11.9 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.17 EAZ51552.1 - 0.18 11.5 0.0 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Ank_4 PF13637.6 EAZ51553.1 - 5.8e-39 132.0 5.2 2.4e-13 50.3 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EAZ51553.1 - 3.2e-31 107.7 1.0 1.5e-13 51.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EAZ51553.1 - 1.4e-23 82.2 0.0 2.7e-06 27.6 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EAZ51553.1 - 1.2e-22 77.5 0.2 0.00018 21.6 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EAZ51553.1 - 1e-20 73.5 0.1 1.2e-07 31.9 0.0 4.5 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Sulfate_transp PF00916.20 EAZ51554.1 - 2.3e-54 184.6 17.5 7.4e-35 120.4 7.6 2.2 2 0 0 2 2 2 2 Sulfate permease family STAS PF01740.21 EAZ51554.1 - 2.4e-10 40.0 0.1 8e-10 38.4 0.1 2.0 1 1 0 1 1 1 1 STAS domain cNMP_binding PF00027.29 EAZ51555.1 - 6.4e-42 141.5 0.0 1.1e-21 76.7 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Methyltransf_4 PF02390.17 EAZ51556.1 - 1.8e-45 154.5 0.0 2.3e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EAZ51556.1 - 5.8e-05 23.7 0.0 9.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EAZ51556.1 - 0.00011 21.8 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW RrnaAD PF00398.20 EAZ51556.1 - 0.00074 18.7 0.0 0.001 18.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.7 EAZ51556.1 - 0.016 15.1 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EAZ51556.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EAZ51556.1 - 0.027 15.1 0.0 0.055 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EAZ51556.1 - 0.028 15.2 0.0 0.047 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EAZ51556.1 - 0.04 13.5 0.0 0.054 13.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 EAZ51556.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 EAZ51556.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ras PF00071.22 EAZ51557.1 - 1e-50 171.5 0.0 1.2e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51557.1 - 2.1e-31 108.6 0.0 5.5e-31 107.3 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51557.1 - 3.2e-12 46.3 0.0 4e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51557.1 - 0.00011 22.3 0.0 0.00023 21.2 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EAZ51557.1 - 0.00098 19.5 0.3 0.013 15.9 0.2 2.4 1 1 1 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 EAZ51557.1 - 0.0012 18.8 0.0 0.57 10.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EAZ51557.1 - 0.0077 15.6 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EAZ51557.1 - 0.0094 15.5 0.6 0.086 12.4 0.6 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ArgoMid PF16487.5 EAZ51557.1 - 0.016 15.4 0.1 0.029 14.6 0.1 1.4 1 0 0 1 1 1 0 Mid domain of argonaute AAA_16 PF13191.6 EAZ51557.1 - 0.023 15.1 0.1 0.045 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EAZ51557.1 - 0.024 13.8 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 EAZ51557.1 - 0.025 15.1 0.1 0.22 12.0 0.0 2.0 2 0 0 2 2 2 0 ABC transporter FixO PF02433.15 EAZ51557.1 - 0.064 12.7 0.0 0.086 12.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO G-alpha PF00503.20 EAZ51557.1 - 0.075 12.2 0.1 7.2 5.7 0.1 2.7 2 1 1 3 3 3 0 G-protein alpha subunit AAA_7 PF12775.7 EAZ51557.1 - 0.087 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EAZ51557.1 - 0.14 11.9 0.1 0.23 11.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EAZ51557.1 - 0.18 12.0 0.1 0.68 10.2 0.0 1.9 3 0 0 3 3 3 0 AAA domain Pkinase PF00069.25 EAZ51558.1 - 4.9e-60 203.1 0.0 6.1e-60 202.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51558.1 - 1.2e-31 110.0 0.0 1.6e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51558.1 - 0.053 12.8 0.0 0.1 11.9 0.0 1.5 1 1 0 1 1 1 0 Kinase-like OHA PF14418.6 EAZ51559.1 - 1.8e-26 91.8 0.0 3.6e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 OST-HTH Associated domain OST-HTH PF12872.7 EAZ51559.1 - 0.00031 20.5 0.4 0.0025 17.6 0.2 2.6 3 0 0 3 3 3 1 OST-HTH/LOTUS domain Pkinase PF00069.25 EAZ51560.1 - 4e-66 223.1 0.0 5.1e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51560.1 - 1.1e-31 110.1 0.0 2e-31 109.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51560.1 - 7.8e-05 22.1 0.0 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EAZ51560.1 - 0.019 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 EAZ51561.1 - 2.2e-23 82.1 12.6 1.2e-06 29.2 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51561.1 - 1.1e-21 76.9 0.4 7.1e-05 23.0 0.0 6.5 3 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EAZ51561.1 - 0.00095 18.2 0.8 0.04 12.9 0.0 3.4 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Invas_SpaK PF03519.14 EAZ51561.1 - 0.059 13.4 1.6 18 5.5 0.5 3.6 2 1 1 3 3 3 0 Invasion protein B family PIG-L PF02585.17 EAZ51562.1 - 2.4e-27 96.2 0.0 2.8e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase SAM_3 PF18016.1 EAZ51562.1 - 0.16 11.8 0.2 25 4.8 0.0 2.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Patched PF02460.18 EAZ51563.1 - 4e-94 316.3 37.0 3.4e-65 220.6 12.0 3.7 4 0 0 4 4 4 3 Patched family Sterol-sensing PF12349.8 EAZ51563.1 - 1.4e-28 99.6 3.1 1.4e-28 99.6 3.1 3.2 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 EAZ51563.1 - 0.16 9.6 11.8 0.26 8.9 11.8 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family RNase_T PF00929.24 EAZ51564.1 - 1.3e-08 35.6 0.0 1.8e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Exonuclease His_Phos_1 PF00300.22 EAZ51564.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) zf-SNAP50_C PF12251.8 EAZ51565.1 - 3e-38 131.5 6.1 3e-38 131.5 6.1 2.2 2 0 0 2 2 2 1 snRNA-activating protein of 50kDa MW C terminal DUF4820 PF16091.5 EAZ51565.1 - 0.017 14.5 0.7 0.024 14.0 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF3915 PF13054.6 EAZ51565.1 - 0.047 13.7 1.6 0.13 12.3 1.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Presenilin PF01080.17 EAZ51565.1 - 0.23 10.2 0.8 0.27 9.9 0.8 1.2 1 0 0 1 1 1 0 Presenilin Ureide_permease PF07168.11 EAZ51565.1 - 0.55 8.9 3.5 2.8 6.6 0.9 2.1 2 0 0 2 2 2 0 Ureide permease Pkinase PF00069.25 EAZ51567.1 - 1.3e-39 136.2 1.8 3.2e-38 131.6 1.8 2.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51567.1 - 2.2e-12 46.8 0.0 4.9e-12 45.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EAZ51567.1 - 0.00089 19.2 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EAZ51567.1 - 0.015 14.9 1.2 0.029 13.9 0.1 1.9 2 1 0 2 2 2 0 Choline/ethanolamine kinase dCMP_cyt_deam_1 PF00383.23 EAZ51568.1 - 5.6e-12 45.4 0.0 1.2e-11 44.4 0.0 1.5 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EAZ51568.1 - 3.8e-06 26.7 0.0 0.0026 17.5 0.0 2.4 2 0 0 2 2 2 2 MafB19-like deaminase DUF4108 PF13390.6 EAZ51568.1 - 0.02 14.8 2.2 0.043 13.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) TPR_1 PF00515.28 EAZ51569.1 - 7.9e-09 35.0 1.2 3.9e-05 23.3 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EAZ51569.1 - 1.7e-07 30.8 0.1 0.00058 19.8 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EAZ51569.1 - 4.2e-06 26.8 0.2 5.2e-05 23.4 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EAZ51569.1 - 5.1e-06 26.3 1.2 4.8e-05 23.2 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EAZ51569.1 - 1.5e-05 25.1 0.9 2e-05 24.7 0.9 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EAZ51569.1 - 0.00017 22.0 0.1 0.00056 20.4 0.1 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 EAZ51569.1 - 0.00064 19.8 0.0 0.00071 19.7 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EAZ51569.1 - 0.0016 19.1 0.0 0.0032 18.2 0.1 1.5 1 1 1 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EAZ51569.1 - 0.0019 18.2 1.6 0.055 13.5 0.5 2.1 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 EAZ51569.1 - 0.0023 18.5 0.0 0.0028 18.3 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_15 PF13429.6 EAZ51569.1 - 0.0041 16.4 0.1 0.0048 16.1 0.1 1.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EAZ51569.1 - 0.0099 15.5 2.1 0.37 10.5 0.1 2.7 2 1 1 3 3 3 1 TPR repeat TPR_6 PF13174.6 EAZ51569.1 - 0.015 15.9 0.1 0.03 15.0 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Guanylate_cyc_2 PF09778.9 EAZ51569.1 - 0.028 13.8 0.1 0.033 13.5 0.1 1.0 1 0 0 1 1 1 0 Guanylylate cyclase IL6 PF00489.17 EAZ51569.1 - 0.048 13.2 0.2 0.051 13.1 0.2 1.1 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family tRNA-synt_2 PF00152.20 EAZ51570.1 - 9.9e-76 254.8 0.0 1.4e-75 254.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EAZ51570.1 - 7.9e-05 22.6 0.1 0.00013 21.8 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EAZ51570.1 - 0.00011 21.8 0.1 0.19 11.1 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Peptidase_S49_N PF08496.10 EAZ51570.1 - 0.066 13.3 3.2 0.1 12.7 3.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal UDG PF03167.19 EAZ51571.1 - 2.6e-07 30.7 0.0 4.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily ECM1 PF05782.11 EAZ51571.1 - 0.011 14.7 0.1 0.018 14.0 0.1 1.3 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) RRP36 PF06102.12 EAZ51571.1 - 0.024 14.6 1.5 0.031 14.3 1.5 1.1 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Ras PF00071.22 EAZ51572.1 - 7.8e-57 191.4 0.1 9.3e-57 191.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51572.1 - 1.5e-31 109.1 0.0 2.4e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51572.1 - 4.9e-12 45.6 0.0 6.2e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EAZ51572.1 - 6.4e-07 29.4 0.0 9.5e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EAZ51572.1 - 7.2e-06 25.5 0.0 1.1e-05 24.9 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EAZ51572.1 - 2.2e-05 24.4 0.0 0.0032 17.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EAZ51572.1 - 4.2e-05 23.2 0.0 0.0011 18.6 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 EAZ51572.1 - 0.0066 16.1 0.0 0.017 14.7 0.0 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EAZ51572.1 - 0.0086 16.5 0.0 0.013 15.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain Septin PF00735.18 EAZ51572.1 - 0.0088 15.3 0.1 0.035 13.4 0.1 1.8 2 0 0 2 2 2 1 Septin SRPRB PF09439.10 EAZ51572.1 - 0.022 14.2 0.1 0.061 12.8 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EAZ51572.1 - 0.025 14.9 0.0 0.058 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EAZ51572.1 - 0.026 14.1 0.1 0.04 13.4 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EAZ51572.1 - 0.034 13.9 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EAZ51572.1 - 0.038 13.8 0.2 1.3 8.7 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EAZ51572.1 - 0.038 13.7 0.7 0.079 12.7 0.2 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 EAZ51572.1 - 0.066 12.3 0.1 0.089 11.9 0.1 1.2 1 0 0 1 1 1 0 MCM P-loop domain TniB PF05621.11 EAZ51572.1 - 0.067 12.6 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DAP3 PF10236.9 EAZ51572.1 - 0.072 12.3 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 G-alpha PF00503.20 EAZ51572.1 - 0.073 12.2 0.7 0.16 11.1 0.7 1.7 1 1 0 1 1 1 0 G-protein alpha subunit RuvB_N PF05496.12 EAZ51572.1 - 0.079 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 EAZ51572.1 - 0.086 12.7 0.5 0.23 11.4 0.1 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EAZ51572.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 EAZ51572.1 - 0.14 12.1 0.0 0.53 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EAZ51572.1 - 0.21 12.1 0.5 0.35 11.4 0.4 1.7 1 1 0 1 1 1 0 ABC transporter HhH-GPD PF00730.25 EAZ51573.1 - 3.4e-22 78.9 0.0 4.4e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EAZ51573.1 - 8.1e-07 28.6 0.0 2.8e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 EAZ51573.1 - 0.00084 19.6 5.8 0.0013 19.0 5.8 1.3 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III Cdd1 PF11731.8 EAZ51573.1 - 0.038 14.2 0.0 0.088 13.0 0.0 1.7 1 1 0 1 1 1 0 Pathogenicity locus DNA_meth_N PF18284.1 EAZ51573.1 - 0.051 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 DNA methylase N-terminal domain HHH_5 PF14520.6 EAZ51573.1 - 0.15 12.7 0.1 0.44 11.2 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_3 PF12836.7 EAZ51573.1 - 0.16 12.2 0.1 0.52 10.6 0.0 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif Slu7 PF11708.8 EAZ51574.1 - 2.3e-68 230.8 11.4 3.5e-68 230.3 11.4 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.23 EAZ51574.1 - 0.0033 17.4 2.0 0.007 16.4 2.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 EAZ51574.1 - 0.029 14.1 0.9 0.074 12.8 0.9 1.7 1 0 0 1 1 1 0 Zinc knuckle DUF2362 PF10154.9 EAZ51574.1 - 0.51 9.2 6.9 2.9 6.7 1.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2362) TIP49 PF06068.13 EAZ51575.1 - 1.5e-158 527.6 0.1 1.8e-158 527.3 0.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EAZ51575.1 - 6.2e-21 74.3 0.1 2.3e-20 72.5 0.1 2.1 2 0 0 2 2 1 1 TIP49 AAA-lid domain AAA PF00004.29 EAZ51575.1 - 1.3e-12 48.3 0.0 4e-08 33.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EAZ51575.1 - 3.5e-09 36.6 0.1 1.6e-06 27.9 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EAZ51575.1 - 1.4e-08 35.1 0.0 0.0018 18.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EAZ51575.1 - 7.8e-06 25.9 0.0 0.00078 19.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EAZ51575.1 - 2.3e-05 24.8 0.2 0.044 14.1 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EAZ51575.1 - 4.3e-05 24.0 0.0 0.00025 21.5 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 EAZ51575.1 - 0.00015 21.6 0.1 0.047 13.4 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 EAZ51575.1 - 0.00017 21.0 0.1 0.0065 15.9 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EAZ51575.1 - 0.001 19.1 0.0 1 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EAZ51575.1 - 0.0013 18.2 0.1 0.0054 16.3 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 EAZ51575.1 - 0.0016 18.7 0.0 0.0027 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EAZ51575.1 - 0.0017 18.0 0.2 0.004 16.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EAZ51575.1 - 0.0019 18.8 0.0 0.0046 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.17 EAZ51575.1 - 0.0029 16.7 0.0 0.0051 15.9 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EAZ51575.1 - 0.0047 16.2 0.1 0.0086 15.4 0.1 1.3 1 0 0 1 1 1 1 Zeta toxin IstB_IS21 PF01695.17 EAZ51575.1 - 0.006 16.3 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 EAZ51575.1 - 0.0067 16.5 0.0 0.13 12.4 0.0 2.7 3 0 0 3 3 3 1 Sigma-54 interaction domain TsaE PF02367.17 EAZ51575.1 - 0.0071 16.4 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EAZ51575.1 - 0.014 15.8 0.1 0.037 14.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 EAZ51575.1 - 0.017 14.8 0.1 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EAZ51575.1 - 0.027 13.8 0.1 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 EAZ51575.1 - 0.03 14.9 0.0 0.22 12.0 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 EAZ51575.1 - 0.033 14.4 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EAZ51575.1 - 0.036 14.0 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain DnaB_C PF03796.15 EAZ51575.1 - 0.041 13.2 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain NACHT PF05729.12 EAZ51575.1 - 0.042 13.8 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_2 PF07724.14 EAZ51575.1 - 0.045 13.9 0.2 0.41 10.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_11 PF13086.6 EAZ51575.1 - 0.046 13.5 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EAZ51575.1 - 0.055 13.8 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 EAZ51575.1 - 0.07 13.0 0.1 0.29 11.0 0.0 2.1 2 1 0 2 2 1 0 NTPase DUF2075 PF09848.9 EAZ51575.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EAZ51575.1 - 0.089 12.2 0.1 0.18 11.2 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein PIF1 PF05970.14 EAZ51575.1 - 0.093 11.9 0.0 9.8 5.2 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase ResIII PF04851.15 EAZ51575.1 - 0.096 12.7 0.1 2 8.4 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 EAZ51575.1 - 0.12 12.1 0.1 0.73 9.6 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain XPG_I PF00867.18 EAZ51576.1 - 1.4e-29 102.3 1.2 4.7e-29 100.6 0.1 2.5 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EAZ51576.1 - 3e-29 101.5 0.0 6.4e-29 100.4 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EAZ51576.1 - 4.5e-07 30.4 0.0 1.9e-06 28.4 0.0 2.2 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 EAZ51576.1 - 0.011 15.9 0.3 0.045 13.8 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif CDKN3 PF05706.12 EAZ51576.1 - 0.049 13.3 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) EMP24_GP25L PF01105.24 EAZ51577.1 - 2.6e-28 99.2 5.8 2.9e-28 99.0 5.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Filamin PF00630.19 EAZ51577.1 - 0.019 15.8 1.3 0.042 14.7 0.4 1.9 2 0 0 2 2 2 0 Filamin/ABP280 repeat Fcf1 PF04900.12 EAZ51578.1 - 2.8e-36 123.9 1.5 3.4e-36 123.6 1.5 1.1 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EAZ51578.1 - 9.5e-13 48.5 0.0 1.1e-12 48.2 0.0 1.1 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 EAZ51578.1 - 0.11 12.7 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 NTF2 fold immunity protein Skp1 PF01466.19 EAZ51579.1 - 1.4e-25 89.2 1.4 1.4e-25 89.2 1.4 1.6 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EAZ51579.1 - 4.9e-18 65.1 0.0 1.1e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Hydrolase_4 PF12146.8 EAZ51580.1 - 9.3e-11 41.4 0.1 1.3e-10 40.9 0.1 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EAZ51580.1 - 7.5e-07 29.0 0.5 5.2e-05 23.0 0.4 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EAZ51580.1 - 0.00016 21.3 0.1 0.00021 21.0 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EAZ51580.1 - 0.0044 17.7 0.0 0.019 15.5 0.0 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF5052 PF16475.5 EAZ51580.1 - 0.016 14.9 0.1 0.032 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5052) Mak10 PF04112.13 EAZ51580.1 - 0.034 13.6 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Metallophos PF00149.28 EAZ51581.1 - 1.3e-41 143.4 0.5 1.6e-41 143.1 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EAZ51581.1 - 7.3e-23 80.8 0.3 1.8e-22 79.5 0.2 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Bromodomain PF00439.25 EAZ51582.1 - 1.9e-19 69.5 0.8 9.8e-19 67.2 0.8 2.4 1 0 0 1 1 1 1 Bromodomain DUF1512 PF07431.12 EAZ51582.1 - 0.15 11.0 0.1 0.33 9.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) UQ_con PF00179.26 EAZ51583.1 - 1.7e-39 134.7 0.1 1.8e-39 134.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EAZ51583.1 - 3.4e-05 23.5 0.0 4.2e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UQ_con PF00179.26 EAZ51584.1 - 4.7e-46 155.9 0.1 5.3e-46 155.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EAZ51584.1 - 3.6e-06 26.7 0.0 4.6e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EAZ51584.1 - 0.033 14.5 1.5 0.058 13.7 1.5 1.7 1 1 0 1 1 1 0 RWD domain Pkinase PF00069.25 EAZ51585.1 - 6.1e-46 156.9 0.0 6.8e-30 104.3 0.0 2.7 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51585.1 - 1.4e-23 83.6 0.0 4.6e-16 58.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51585.1 - 9e-06 25.2 0.0 0.015 14.6 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EAZ51585.1 - 9.9e-05 21.3 0.0 0.00017 20.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EAZ51585.1 - 0.14 11.5 0.3 0.26 10.6 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family S1-P1_nuclease PF02265.16 EAZ51586.1 - 3.4e-19 69.7 0.0 4.2e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 S1/P1 Nuclease Phospholamban PF04272.14 EAZ51586.1 - 0.1 12.1 4.4 0.23 11.0 4.4 1.6 1 0 0 1 1 1 0 Phospholamban DNA_RNApol_7kD PF03604.13 EAZ51587.1 - 1.8e-16 59.5 6.3 2.2e-16 59.2 6.3 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 EAZ51587.1 - 0.0078 16.2 1.0 0.0081 16.2 1.0 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EAZ51587.1 - 0.0094 16.0 1.1 0.012 15.7 1.1 1.2 1 0 0 1 1 1 1 Double zinc ribbon Zn_ribbon_SprT PF17283.2 EAZ51587.1 - 0.012 15.5 3.8 0.018 14.9 3.7 1.4 1 1 0 1 1 1 0 SprT-like zinc ribbon domain DUF2757 PF10955.8 EAZ51587.1 - 0.015 15.6 0.2 0.017 15.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) Zn-ribbon_8 PF09723.10 EAZ51587.1 - 0.02 15.0 0.9 0.029 14.5 0.9 1.4 1 0 0 1 1 1 0 Zinc ribbon domain zinc-ribbon_6 PF10005.9 EAZ51587.1 - 0.043 14.5 0.5 0.05 14.3 0.5 1.1 1 0 0 1 1 1 0 zinc-ribbon domain DUF1451 PF07295.11 EAZ51587.1 - 0.067 13.2 1.3 0.072 13.1 1.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf_UBZ PF18439.1 EAZ51587.1 - 0.2 11.3 1.3 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Helicase_C_2 PF13307.6 EAZ51588.1 - 3.5e-47 160.7 1.2 6.2e-47 159.9 0.1 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EAZ51588.1 - 5.6e-35 120.5 9.4 5.6e-35 120.5 9.4 2.0 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 EAZ51588.1 - 0.026 14.3 0.0 0.24 11.2 0.0 2.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase ResIII PF04851.15 EAZ51588.1 - 0.12 12.3 8.3 15 5.6 4.1 3.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit NADH_dehy_S2_C PF06444.11 EAZ51588.1 - 0.73 10.4 3.9 0.62 10.6 1.4 2.3 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus Pkinase PF00069.25 EAZ51589.1 - 2.1e-60 204.4 0.0 2.3e-60 204.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51589.1 - 1.9e-34 119.1 0.0 2.2e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51589.1 - 1.1e-08 34.8 0.0 2.4e-08 33.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51589.1 - 1.7e-05 23.8 0.0 2.3e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EAZ51589.1 - 0.00033 20.6 0.0 0.043 13.7 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EAZ51590.1 - 5.3e-71 239.1 0.1 6.7e-71 238.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51590.1 - 4.5e-38 131.0 0.0 5.8e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EAZ51590.1 - 2.7e-07 29.9 3.3 4.5e-07 29.1 3.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EAZ51590.1 - 1.9e-06 27.5 0.0 0.00013 21.3 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 EAZ51590.1 - 0.0052 16.2 0.1 0.0076 15.6 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EAZ51590.1 - 0.014 14.2 0.1 0.031 13.0 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EAZ51590.1 - 0.029 14.3 0.0 0.39 10.6 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 EAZ51590.1 - 0.054 13.1 0.2 0.12 12.0 0.1 1.6 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 EAZ51591.1 - 1.1e-34 117.8 12.3 2.4e-07 31.3 0.4 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EAZ51591.1 - 2.1e-08 34.3 1.1 0.24 11.7 0.1 5.4 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EAZ51591.1 - 3.3e-05 22.7 2.2 0.13 10.9 0.1 3.9 3 2 1 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EAZ51591.1 - 0.00031 19.6 2.2 0.84 8.3 0.4 3.9 1 1 2 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 EAZ51591.1 - 0.022 14.1 0.3 1.2 8.4 0.0 2.9 2 1 1 3 3 3 0 WD40-like domain Ricin_B_lectin PF00652.22 EAZ51591.1 - 0.025 14.9 0.1 7.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain SBBP PF06739.11 EAZ51591.1 - 0.038 14.0 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Beta-propeller repeat LSM PF01423.22 EAZ51592.1 - 2.4e-18 65.6 1.2 2.8e-18 65.3 1.2 1.0 1 0 0 1 1 1 1 LSM domain Atg8 PF02991.16 EAZ51593.1 - 3.4e-31 107.5 2.1 1.1e-29 102.7 2.1 2.0 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EAZ51593.1 - 1.2e-05 25.7 1.2 0.00037 20.9 1.2 2.0 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 RCC1_2 PF13540.6 EAZ51594.1 - 0.00014 21.6 5.1 0.082 12.7 0.0 4.4 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat ArAE_2_N PF10337.9 EAZ51594.1 - 1.9 7.4 8.2 3.8 6.4 8.2 1.4 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal ArsA_ATPase PF02374.15 EAZ51595.1 - 1.6e-86 290.2 1.2 3.8e-81 272.6 0.2 2.0 1 1 1 2 2 2 2 Anion-transporting ATPase CbiA PF01656.23 EAZ51595.1 - 4.6e-12 46.1 0.0 3.9e-11 43.1 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EAZ51595.1 - 1e-11 45.1 1.9 2.9e-10 40.4 0.0 2.7 2 2 0 2 2 2 1 AAA domain Fer4_NifH PF00142.18 EAZ51595.1 - 7.3e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EAZ51595.1 - 1.6e-05 24.5 0.1 0.00026 20.5 0.0 2.2 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EAZ51595.1 - 0.00075 19.2 0.0 0.0039 16.8 0.0 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EAZ51595.1 - 0.0013 18.3 0.0 0.0048 16.4 0.0 1.8 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ Palm_thioest PF02089.15 EAZ51595.1 - 0.019 14.8 0.8 0.039 13.8 0.6 1.5 1 1 0 1 1 1 0 Palmitoyl protein thioesterase Zeta_toxin PF06414.12 EAZ51595.1 - 0.026 13.8 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 EAZ51595.1 - 0.046 14.3 0.2 0.21 12.1 0.1 2.2 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EAZ51595.1 - 0.057 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 EAZ51595.1 - 0.13 12.1 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EAZ51595.1 - 0.15 11.6 0.1 0.39 10.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EAZ51595.1 - 0.16 11.6 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Clat_adaptor_s PF01217.20 EAZ51596.1 - 3.6e-06 27.0 0.0 4.6e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SecE PF00584.20 EAZ51597.1 - 7.9e-12 44.9 0.0 9.8e-12 44.6 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex TerY_C PF15616.6 EAZ51598.1 - 0.38 10.9 3.5 6.2 6.9 0.2 2.2 2 0 0 2 2 2 0 TerY-C metal binding domain RNA_pol_L_2 PF13656.6 EAZ51599.1 - 1.3e-24 85.7 0.0 1.7e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EAZ51599.1 - 0.00043 19.7 0.1 0.00071 19.0 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Ras PF00071.22 EAZ51600.1 - 7.5e-51 171.9 0.0 8.8e-51 171.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EAZ51600.1 - 8.1e-31 106.7 0.0 1.4e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EAZ51600.1 - 1.8e-14 53.5 0.0 2.2e-14 53.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EAZ51600.1 - 1.1e-06 28.2 0.0 1.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EAZ51600.1 - 0.00014 21.9 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EAZ51600.1 - 0.0026 17.3 0.0 0.0086 15.6 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EAZ51600.1 - 0.011 15.2 0.0 0.032 13.7 0.0 1.7 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EAZ51600.1 - 0.034 13.6 0.0 0.16 11.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 EAZ51600.1 - 0.075 13.4 0.0 0.11 12.8 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EAZ51600.1 - 0.11 12.8 0.1 0.4 10.9 0.0 2.0 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 EAZ51601.1 - 5.1e-52 176.0 0.1 2.1e-27 96.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EAZ51601.1 - 4.1e-38 131.6 27.5 3.2e-30 105.7 8.8 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EAZ51601.1 - 1.6e-07 31.0 10.3 0.0097 15.4 0.2 4.2 2 2 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EAZ51601.1 - 0.00011 21.9 0.8 0.1 12.4 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EAZ51601.1 - 0.0012 18.9 0.7 0.4 10.8 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EAZ51601.1 - 0.0058 16.6 0.3 0.62 9.9 0.1 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EAZ51601.1 - 0.0089 16.4 0.5 3.3 8.1 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain DUF1691 PF07950.11 EAZ51601.1 - 0.094 13.4 0.5 0.42 11.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1691) T2SSE PF00437.20 EAZ51601.1 - 0.097 11.7 0.0 1.4 8.0 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EAZ51601.1 - 0.18 11.1 0.9 15 4.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 EAZ51601.1 - 0.21 12.0 7.0 2.2 8.7 0.1 3.4 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EAZ51601.1 - 2.4 8.2 7.8 2.2 8.3 0.1 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain ubiquitin PF00240.23 EAZ51602.1 - 4e-24 84.1 1.0 4.4e-24 84.0 1.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EAZ51602.1 - 2e-13 50.0 0.7 2.2e-13 49.8 0.7 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EAZ51602.1 - 0.00021 21.6 0.3 0.0006 20.2 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EAZ51602.1 - 0.00042 20.4 0.1 0.00088 19.4 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EAZ51602.1 - 0.0019 18.5 0.4 0.0023 18.2 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 EAZ51602.1 - 0.025 15.1 0.0 0.03 14.9 0.0 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Prefoldin_2 PF01920.20 EAZ51603.1 - 4.4e-23 81.3 4.6 5.2e-23 81.0 4.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EAZ51603.1 - 0.00019 21.3 6.3 0.0015 18.5 6.3 1.9 1 1 0 1 1 1 1 Prefoldin subunit OmpH PF03938.14 EAZ51603.1 - 0.0017 18.7 0.9 0.0074 16.6 0.3 1.9 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Spc7 PF08317.11 EAZ51603.1 - 0.0029 16.5 4.6 0.032 13.1 0.7 2.0 2 0 0 2 2 2 1 Spc7 kinetochore protein Lectin_N PF03954.14 EAZ51603.1 - 0.0036 17.0 0.5 0.0055 16.4 0.3 1.4 1 1 0 1 1 1 1 Hepatic lectin, N-terminal domain SlyX PF04102.12 EAZ51603.1 - 0.004 17.7 1.2 2.5 8.8 0.1 2.2 2 0 0 2 2 2 0 SlyX Spc24 PF08286.11 EAZ51603.1 - 0.004 17.4 5.1 0.13 12.5 3.2 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 DUF677 PF05055.12 EAZ51603.1 - 0.0041 16.1 2.3 0.13 11.1 0.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF677) DUF5320 PF17253.2 EAZ51603.1 - 0.006 17.6 1.0 0.034 15.2 0.0 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5320) APG6_N PF17675.1 EAZ51603.1 - 0.0062 17.1 7.0 0.03 14.9 2.2 2.1 2 0 0 2 2 2 1 Apg6 coiled-coil region DUF2802 PF10975.8 EAZ51603.1 - 0.011 15.9 1.1 0.69 10.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) NPV_P10 PF05531.12 EAZ51603.1 - 0.012 16.1 1.0 2.3 8.7 0.1 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF5082 PF16888.5 EAZ51603.1 - 0.015 15.6 6.7 1.9 8.8 6.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.12 EAZ51603.1 - 0.016 15.2 0.3 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4618 PF15397.6 EAZ51603.1 - 0.018 14.4 4.4 0.41 10.0 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) BRE1 PF08647.11 EAZ51603.1 - 0.019 15.1 8.0 0.022 14.8 1.5 2.1 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase CLZ PF16526.5 EAZ51603.1 - 0.021 15.2 3.8 2.8 8.4 1.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YscO-like PF16789.5 EAZ51603.1 - 0.024 14.7 4.8 0.053 13.5 0.9 2.0 2 0 0 2 2 2 0 YscO-like protein MbeD_MobD PF04899.12 EAZ51603.1 - 0.025 14.7 0.5 3.5 7.8 0.0 2.5 3 0 0 3 3 2 0 MbeD/MobD like FlxA PF14282.6 EAZ51603.1 - 0.026 14.5 14.9 0.061 13.3 0.9 2.8 2 1 1 3 3 2 0 FlxA-like protein TMF_DNA_bd PF12329.8 EAZ51603.1 - 0.028 14.4 14.1 0.24 11.4 1.4 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SKA1 PF07160.12 EAZ51603.1 - 0.028 14.3 3.6 0.13 12.1 1.2 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Snf7 PF03357.21 EAZ51603.1 - 0.032 13.8 4.5 0.094 12.3 0.7 2.0 2 0 0 2 2 2 0 Snf7 DUF4140 PF13600.6 EAZ51603.1 - 0.038 14.4 1.2 0.89 10.0 0.2 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Seryl_tRNA_N PF02403.22 EAZ51603.1 - 0.038 14.2 4.6 0.91 9.8 1.1 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Ax_dynein_light PF10211.9 EAZ51603.1 - 0.041 13.8 3.8 0.33 10.9 0.8 2.0 2 0 0 2 2 2 0 Axonemal dynein light chain LRRFIP PF09738.9 EAZ51603.1 - 0.041 13.4 6.3 0.048 13.1 6.3 1.0 1 0 0 1 1 1 0 LRRFIP family DUF4407 PF14362.6 EAZ51603.1 - 0.05 13.0 2.8 0.33 10.3 2.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) E2F_CC-MB PF16421.5 EAZ51603.1 - 0.051 13.9 2.4 3.5 8.1 0.2 2.2 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain GrpE PF01025.19 EAZ51603.1 - 0.052 13.2 4.4 0.24 11.1 1.1 2.0 2 0 0 2 2 2 0 GrpE Tropomyosin_1 PF12718.7 EAZ51603.1 - 0.055 13.6 8.9 0.19 11.9 3.2 2.1 2 0 0 2 2 2 0 Tropomyosin like DUF16 PF01519.16 EAZ51603.1 - 0.056 13.9 2.5 0.46 11.0 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 DASH_Dad3 PF08656.10 EAZ51603.1 - 0.056 13.5 1.4 4.3 7.5 0.1 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad3 ZapB PF06005.12 EAZ51603.1 - 0.058 13.8 6.8 1 9.8 2.2 2.1 2 0 0 2 2 2 0 Cell division protein ZapB Laminin_I PF06008.14 EAZ51603.1 - 0.067 12.9 5.2 0.27 10.9 5.2 1.7 1 1 1 2 2 2 0 Laminin Domain I Cep57_CLD_2 PF14197.6 EAZ51603.1 - 0.068 13.3 7.3 0.41 10.8 2.6 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Med4 PF10018.9 EAZ51603.1 - 0.081 12.6 3.8 0.094 12.4 0.5 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF948 PF06103.11 EAZ51603.1 - 0.081 13.2 1.1 0.64 10.3 0.3 2.1 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) XhlA PF10779.9 EAZ51603.1 - 0.091 13.0 5.5 2.6 8.3 0.1 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF4047 PF13256.6 EAZ51603.1 - 0.093 12.9 1.4 0.18 12.0 1.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) FliD_N PF02465.18 EAZ51603.1 - 0.094 13.4 4.6 0.54 11.0 1.8 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4795 PF16043.5 EAZ51603.1 - 0.095 12.3 4.2 0.28 10.8 4.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) BRI3BP PF14965.6 EAZ51603.1 - 0.1 12.1 0.8 11 5.5 0.0 2.2 2 0 0 2 2 2 0 Negative regulator of p53/TP53 GAT PF03127.14 EAZ51603.1 - 0.11 12.9 2.2 6.4 7.2 0.4 2.1 2 0 0 2 2 2 0 GAT domain DUF4600 PF15372.6 EAZ51603.1 - 0.11 13.0 4.9 0.51 10.8 4.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) HalX PF08663.10 EAZ51603.1 - 0.11 12.8 3.6 0.97 9.8 0.9 2.2 2 0 0 2 2 2 0 HalX domain ACP_PD PF04336.12 EAZ51603.1 - 0.11 12.9 0.1 0.36 11.3 0.0 1.7 2 0 0 2 2 1 0 Acyl carrier protein phosphodiesterase BST2 PF16716.5 EAZ51603.1 - 0.12 12.9 6.4 0.16 12.5 2.0 2.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF1845 PF08900.11 EAZ51603.1 - 0.13 12.0 0.8 0.97 9.1 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1845) LPP PF04728.13 EAZ51603.1 - 0.13 12.7 4.0 2.3 8.6 0.3 2.5 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Vps51 PF08700.11 EAZ51603.1 - 0.13 12.3 3.4 5 7.3 0.1 2.5 2 1 0 2 2 2 0 Vps51/Vps67 ApoO PF09769.9 EAZ51603.1 - 0.15 12.0 0.3 0.27 11.2 0.1 1.5 2 0 0 2 2 1 0 Apolipoprotein O Nas2_N PF18265.1 EAZ51603.1 - 0.15 12.0 0.5 0.15 12.0 0.5 2.4 2 1 1 3 3 3 0 Nas2 N_terminal domain CCDC-167 PF15188.6 EAZ51603.1 - 0.15 12.4 3.5 0.59 10.5 3.5 1.9 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 ADIP PF11559.8 EAZ51603.1 - 0.16 12.0 4.6 0.53 10.4 0.6 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EAZ51603.1 - 0.17 11.9 8.8 0.59 10.2 2.7 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EAZ51603.1 - 0.17 12.0 8.8 0.29 11.2 2.2 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Rho_Binding PF08912.11 EAZ51603.1 - 0.26 12.1 7.4 1.9 9.4 2.1 2.4 2 0 0 2 2 2 0 Rho Binding Tho2 PF11262.8 EAZ51603.1 - 0.26 10.5 2.4 7 5.7 0.1 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 TMF_TATA_bd PF12325.8 EAZ51603.1 - 0.28 11.4 7.0 0.22 11.8 2.1 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.9 EAZ51603.1 - 0.28 11.5 5.6 8.7 6.7 0.1 2.5 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Swi5 PF07061.11 EAZ51603.1 - 0.29 11.2 7.5 1.5 8.9 2.3 2.3 1 1 1 2 2 2 0 Swi5 DUF3086 PF11285.8 EAZ51603.1 - 0.35 9.9 2.5 0.18 10.9 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) FlaC_arch PF05377.11 EAZ51603.1 - 0.35 11.3 6.8 1.3 9.5 2.0 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EAZ51603.1 - 0.37 10.8 2.8 1.9 8.6 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EAZ51603.1 - 0.48 10.6 9.2 5.3 7.2 3.4 2.7 2 1 0 2 2 2 0 bZIP transcription factor DUF4665 PF15679.5 EAZ51603.1 - 0.49 11.1 5.3 4.9 7.8 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) DivIC PF04977.15 EAZ51603.1 - 0.66 9.8 6.8 1.9 8.3 0.8 2.2 2 0 0 2 2 2 0 Septum formation initiator Helo_like_N PF17111.5 EAZ51603.1 - 0.7 9.2 5.4 0.82 9.0 0.6 2.0 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins ABC_tran_CTD PF16326.5 EAZ51603.1 - 0.82 10.0 9.0 8.1 6.8 5.3 2.5 2 1 0 2 2 2 0 ABC transporter C-terminal domain Syntaxin-6_N PF09177.11 EAZ51603.1 - 0.89 10.1 5.6 5 7.8 5.6 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TSC22 PF01166.18 EAZ51603.1 - 0.96 9.8 4.6 4.9 7.5 0.9 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family FmiP_Thoc5 PF09766.9 EAZ51603.1 - 0.99 8.6 6.6 0.82 8.9 1.6 2.0 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 Allexi_40kDa PF05549.11 EAZ51603.1 - 1.8 8.0 5.6 3.3 7.2 1.2 2.1 1 1 0 2 2 2 0 Allexivirus 40kDa protein Ribosomal_S4e PF00900.20 EAZ51604.1 - 9.5e-28 95.9 1.5 1.2e-27 95.6 0.3 1.8 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.12 EAZ51604.1 - 7.4e-21 74.0 3.5 1.3e-20 73.2 3.5 1.4 1 0 0 1 1 1 1 RS4NT (NUC023) domain 40S_S4_C PF16121.5 EAZ51604.1 - 4.5e-20 71.0 0.1 7.5e-20 70.3 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 EAZ51604.1 - 6.9e-08 32.1 0.0 1.3e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EAZ51604.1 - 0.00045 20.1 0.1 0.00045 20.1 0.1 2.9 4 0 0 4 4 4 1 KOW motif Pkinase PF00069.25 EAZ51605.1 - 6.9e-48 163.3 0.0 8.3e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51605.1 - 2e-26 92.8 0.0 2.9e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EAZ51605.1 - 0.0007 18.6 0.2 0.00098 18.2 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EAZ51605.1 - 0.01 15.5 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EAZ51605.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EAZ51608.1 - 5.6e-59 199.7 0.0 6.7e-58 196.1 0.0 2.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EAZ51608.1 - 1.1e-37 129.7 0.0 2.6e-37 128.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EAZ51608.1 - 7e-06 25.6 0.1 2e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EAZ51608.1 - 0.00014 20.8 0.1 0.00067 18.5 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase EF-hand_11 PF08976.11 EAZ51608.1 - 0.00039 21.3 0.0 0.001 19.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain APH PF01636.23 EAZ51608.1 - 0.18 11.7 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CdhC PF03598.15 EAZ51608.1 - 0.41 10.5 2.0 0.64 9.9 0.7 2.0 2 0 0 2 2 2 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_parvum-IowaII-ASM16534v1/GCA_000165345.1_ASM16534v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_parvum-IowaII-ASM16534v1/GCA_000165345.1_ASM16534v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_parvum-IowaII-ASM16534v1/GCA_000165345.1_ASM16534v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_parvum-IowaII-ASM16534v1/GCA_000165345.1_ASM16534v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 00:29:08 2019 # [ok]