# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Pkinase PF00069.25 EEA04697.1 - 1e-27 97.2 0.0 1.6e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA04697.1 - 2.8e-17 62.9 0.0 3.7e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA04697.1 - 6.5e-09 35.1 0.9 1.3e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EEA04697.1 - 0.0099 15.8 0.1 0.028 14.3 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EEA04697.1 - 0.07 12.7 0.4 0.24 11.0 0.0 2.1 3 0 0 3 3 3 0 RIO1 family Kdo PF06293.14 EEA04697.1 - 0.15 11.4 0.1 0.26 10.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF676 PF05057.14 EEA04698.1 - 2.9e-42 144.7 0.0 5.3e-42 143.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 EEA04698.1 - 2e-18 66.7 0.6 2e-18 66.7 0.6 2.9 3 0 0 3 3 3 1 Protein FAM135 Palm_thioest PF02089.15 EEA04698.1 - 8.9e-05 22.4 0.0 0.00026 20.9 0.0 1.8 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EEA04698.1 - 0.00047 19.9 0.0 0.0056 16.4 0.0 2.2 1 1 0 1 1 1 1 PGAP1-like protein DUF900 PF05990.12 EEA04698.1 - 0.084 12.4 0.1 0.23 10.9 0.1 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Oxidored_nitro PF00148.19 EEA04698.1 - 0.11 11.2 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase ArfGap PF01412.18 EEA04699.1 - 0.015 15.3 3.0 0.015 15.3 3.0 2.2 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Scm3 PF10384.9 EEA04700.1 - 0.0017 18.1 0.4 0.0056 16.4 0.4 2.0 1 0 0 1 1 1 1 Centromere protein Scm3 AdoHcyase PF05221.17 EEA04701.1 - 1.3e-122 408.6 0.1 1.8e-122 408.2 0.1 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EEA04701.1 - 3.1e-69 232.2 2.5 5e-69 231.5 2.5 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EEA04701.1 - 1.2e-06 28.0 0.2 3.7e-06 26.4 0.2 1.8 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EEA04701.1 - 0.0072 15.9 0.2 0.013 15.0 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EEA04701.1 - 0.019 15.2 0.7 0.11 12.7 0.7 2.2 1 1 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EEA04701.1 - 0.048 13.7 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Endonuc-dimeris PF09124.10 EEA04701.1 - 0.14 12.4 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation WD40 PF00400.32 EEA04702.1 - 0.0021 18.9 2.2 13 6.8 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat UPF0020 PF01170.18 EEA04703.1 - 1.2e-12 47.9 0.1 1.9e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EEA04703.1 - 5.8e-06 26.2 0.2 0.0004 20.2 0.0 2.5 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.16 EEA04703.1 - 0.006 15.9 0.0 0.12 11.7 0.0 2.3 2 0 0 2 2 2 1 N-6 DNA Methylase T4_neck-protein PF11649.8 EEA04703.1 - 0.022 14.1 0.5 0.038 13.3 0.5 1.3 1 0 0 1 1 1 0 Virus neck protein HOCHOB PF17943.1 EEA04703.1 - 0.057 14.1 0.2 21 5.9 0.0 2.6 2 0 0 2 2 2 0 Homeobox-cysteine loop-homeobox Efg1 PF10153.9 EEA04704.1 - 8.8e-16 58.3 12.7 8.8e-16 58.3 12.7 2.9 3 1 0 3 3 3 1 rRNA-processing protein Efg1 MEDS PF14417.6 EEA04704.1 - 0.097 12.5 0.4 0.26 11.1 0.1 1.9 2 1 0 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF2096 PF09869.9 EEA04704.1 - 0.19 11.8 11.1 0.035 14.2 1.4 3.1 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) tRNA-synt_1d PF00750.19 EEA04705.1 - 1.6e-120 402.3 1.7 2.8e-120 401.4 1.7 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EEA04705.1 - 3.7e-25 88.4 0.1 7.6e-25 87.4 0.1 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EEA04705.1 - 8.3e-15 55.1 0.4 3.1e-14 53.3 0.1 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EEA04705.1 - 0.00014 21.3 0.1 0.00044 19.7 0.1 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EEA04705.1 - 0.0046 15.8 0.1 0.13 11.0 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (M) DUF2067 PF09840.9 EEA04705.1 - 0.013 15.1 1.0 0.34 10.5 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) DapB_N PF01113.20 EEA04705.1 - 0.033 14.3 0.0 0.085 13.0 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Pkinase PF00069.25 EEA04706.1 - 1.9e-15 57.0 1.2 7.8e-09 35.3 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA04706.1 - 2e-09 37.1 1.1 2.3e-05 23.8 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 EEA04706.1 - 0.0019 17.6 0.1 0.0033 16.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA04706.1 - 0.0026 17.1 0.3 0.35 10.2 0.1 2.3 2 0 0 2 2 2 2 Kinase-like ETS_PEA3_N PF04621.13 EEA04706.1 - 0.014 15.3 2.5 0.024 14.5 2.5 1.4 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain APH PF01636.23 EEA04706.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S9 PF00326.21 EEA04708.1 - 3.1e-33 115.0 0.0 4.6e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EEA04708.1 - 4.1e-10 39.7 1.4 9e-07 28.8 0.5 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA04708.1 - 6.5e-07 28.9 0.0 0.0018 17.6 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA04708.1 - 0.00018 21.4 0.0 0.26 11.1 0.0 2.5 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 EEA04708.1 - 0.071 12.7 0.0 4.4 6.8 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EEA04708.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.13 EEA04708.1 - 0.13 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA04708.1 - 0.17 12.4 0.0 0.24 12.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family zf-4CXXC_R1 PF10497.9 EEA04709.1 - 0.091 13.0 17.6 0.085 13.1 13.2 2.9 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Methyltransf_31 PF13847.6 EEA04712.1 - 1.3e-15 57.5 0.2 3e-15 56.3 0.2 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA04712.1 - 6.1e-07 30.1 0.0 1.8e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EEA04712.1 - 2.5e-06 27.5 0.1 8.1e-06 25.8 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA04712.1 - 5.7e-06 26.9 0.0 1.3e-05 25.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA04712.1 - 1.6e-05 25.5 0.1 3.1e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA04712.1 - 0.00012 21.6 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EEA04712.1 - 0.00037 20.4 0.0 0.00049 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EEA04712.1 - 0.00069 19.2 0.1 0.00082 19.0 0.1 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 PrmA PF06325.13 EEA04712.1 - 0.0027 17.2 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EEA04712.1 - 0.004 16.9 0.0 0.0063 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EEA04712.1 - 0.005 16.3 0.0 0.0093 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase TrmK PF04816.12 EEA04712.1 - 0.015 14.8 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase MetW PF07021.12 EEA04712.1 - 0.026 14.1 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CMAS PF02353.20 EEA04712.1 - 0.034 13.5 0.1 0.063 12.6 0.1 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_20 PF12147.8 EEA04712.1 - 0.041 13.0 0.1 0.063 12.4 0.1 1.4 1 1 0 1 1 1 0 Putative methyltransferase AdoMet_MTase PF07757.13 EEA04712.1 - 0.043 14.1 0.1 0.09 13.1 0.0 1.7 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase Methyltransf_9 PF08003.11 EEA04712.1 - 0.049 12.5 0.0 0.073 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Frataxin_Cyay PF01491.16 EEA04713.1 - 1.4e-23 83.0 0.2 1.9e-23 82.6 0.2 1.2 1 0 0 1 1 1 1 Frataxin-like domain AAA_6 PF12774.7 EEA04714.1 - 0.083 11.8 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region C2 PF00168.30 EEA04715.1 - 0.013 15.7 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 C2 domain SNF2_N PF00176.23 EEA04716.1 - 4.5e-54 183.5 0.0 1.4e-53 181.9 0.0 1.8 1 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA04716.1 - 6.4e-15 55.5 0.0 2e-14 53.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Codanin-1_C PF15296.6 EEA04716.1 - 0.021 14.9 0.2 0.18 11.9 0.0 2.4 2 0 0 2 2 2 0 Codanin-1 C-terminus T6PP_N PF18572.1 EEA04717.1 - 4.6 7.1 10.7 5.5 6.9 0.7 3.3 1 1 1 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain PIG-S PF10510.9 EEA04718.1 - 3.4e-07 29.5 5.0 1.6e-06 27.2 5.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein GBP PF02263.19 EEA04718.1 - 0.0038 16.5 1.0 0.0058 15.9 0.1 1.6 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain ATP11 PF06644.11 EEA04719.1 - 2.6e-18 66.8 0.4 3.4e-18 66.4 0.4 1.1 1 0 0 1 1 1 1 ATP11 protein Sigma70_r1_2 PF00140.20 EEA04719.1 - 0.005 16.8 0.1 0.0092 16.0 0.1 1.5 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 DUF4017 PF13209.6 EEA04719.1 - 0.042 13.8 0.1 0.095 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4017) WD40 PF00400.32 EEA04720.1 - 3.1e-08 34.2 1.6 1.8 9.5 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA04720.1 - 5.8e-05 23.3 0.0 0.066 13.5 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EEA04720.1 - 0.064 11.6 0.0 0.1 10.9 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 EEA04720.1 - 0.066 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain DUF1513 PF07433.11 EEA04720.1 - 0.21 10.7 0.0 8.4 5.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Gas_vesicle PF00741.18 EEA04722.1 - 0.21 11.8 1.3 0.4 10.9 1.3 1.4 1 0 0 1 1 1 0 Gas vesicle protein CH PF00307.31 EEA04723.1 - 1.8 8.8 7.3 0.51 10.5 0.8 3.2 3 1 0 3 3 3 0 Calponin homology (CH) domain DUF3522 PF12036.8 EEA04724.1 - 4.8e-17 62.9 19.9 1.7e-15 57.8 19.9 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3522) DUF2935 PF11155.8 EEA04724.1 - 4.8 7.5 6.8 1 9.7 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) EGF PF00008.27 EEA04724.1 - 4.9 7.5 7.8 13 6.2 7.8 1.8 1 0 0 1 1 1 0 EGF-like domain HAD_2 PF13419.6 EEA04725.1 - 0.12 12.5 2.1 0.78 9.8 2.1 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Proteasome PF00227.26 EEA04726.1 - 7e-44 149.6 0.4 9e-44 149.2 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit YedD PF13987.6 EEA04726.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 YedD-like protein Ig_Tie2_1 PF10430.9 EEA04727.1 - 0.12 12.8 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Sec1 PF00995.23 EEA04729.1 - 1.3e-113 381.3 23.5 1.5e-113 381.1 23.5 1.0 1 0 0 1 1 1 1 Sec1 family Sld5 PF05916.11 EEA04731.1 - 0.014 15.8 0.4 0.027 14.9 0.4 1.4 1 0 0 1 1 1 0 GINS complex protein AAA_26 PF13500.6 EEA04731.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain PP2C PF00481.21 EEA04732.1 - 9.3e-45 153.3 0.0 1.6e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EEA04732.1 - 9.2e-05 22.4 0.0 0.0003 20.8 0.0 1.7 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EEA04732.1 - 0.077 12.6 0.0 0.96 9.0 0.0 2.6 1 1 0 1 1 1 0 Protein phosphatase 2C RecG_N PF17190.4 EEA04735.1 - 0.48 11.2 22.9 5.3 7.9 1.1 5.3 5 0 0 5 5 5 0 RecG N-terminal helical domain ABC_tran PF00005.27 EEA04737.1 - 9.1e-19 68.3 0.0 4.7e-15 56.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA04737.1 - 1.7e-05 24.6 18.5 1.7e-05 24.6 18.5 3.5 3 1 0 3 3 3 2 ABC transporter transmembrane region MMR_HSR1 PF01926.23 EEA04737.1 - 0.0033 17.5 1.2 0.0096 16.0 1.2 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4014 PF13198.6 EEA04737.1 - 0.095 13.1 1.1 0.46 10.9 1.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4014) NB-ARC PF00931.22 EEA04737.1 - 0.12 11.5 0.8 0.25 10.5 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.6 EEA04737.1 - 0.17 11.7 0.1 0.49 10.2 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 EEA04737.1 - 0.38 10.8 3.1 0.71 9.9 0.3 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain SMC_N PF02463.19 EEA04737.1 - 0.38 10.1 3.5 1.9 7.9 0.9 2.5 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain DUF2628 PF10947.8 EEA04737.1 - 1.5 9.2 5.5 7.9 6.9 5.5 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Peptidase_C1 PF00112.23 EEA04738.1 - 3.7e-37 128.5 5.4 5.5e-37 128.0 5.4 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EEA04738.1 - 0.0015 17.4 0.2 0.0033 16.3 0.2 1.5 1 0 0 1 1 1 1 Peptidase C1-like family DUF273 PF03314.14 EEA04738.1 - 0.1 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF273 GST_C_3 PF14497.6 EEA04739.1 - 2e-05 24.7 0.0 5.9e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Arm_3 PF16186.5 EEA04741.1 - 0.0003 20.3 0.2 0.00084 18.9 0.2 1.8 1 0 0 1 1 1 1 Atypical Arm repeat AMP-binding PF00501.28 EEA04742.1 - 1.8e-74 250.9 0.0 2.4e-74 250.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA04742.1 - 0.0063 17.5 0.0 0.014 16.3 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF155 PF02582.14 EEA04742.1 - 0.043 13.9 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 DUF2070 PF09843.9 EEA04744.1 - 0.15 10.3 8.0 0.2 9.9 8.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PH_3 PF14593.6 EEA04745.1 - 0.084 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 PH domain DUF900 PF05990.12 EEA04746.1 - 3.4e-25 88.9 0.0 8e-25 87.7 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) DUF5547 PF17701.1 EEA04746.1 - 0.01 15.7 1.2 0.017 15.0 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5547) Reprolysin_4 PF13583.6 EEA04747.1 - 0.061 13.0 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like KxDL PF10241.9 EEA04747.1 - 0.067 13.5 0.8 0.58 10.5 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein CDC24_OB2 PF17245.2 EEA04749.1 - 0.022 15.3 1.9 0.21 12.1 0.0 2.9 4 0 0 4 4 4 0 Cell division control protein 24, OB domain 2 MFS_1 PF07690.16 EEA04752.1 - 7.4e-05 21.8 36.9 0.00013 21.0 36.9 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4998 PF16389.5 EEA04753.1 - 0.023 14.3 0.1 0.11 12.1 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function zf-DNL PF05180.12 EEA04754.1 - 0.0072 16.2 1.2 3.1 7.8 0.1 2.8 2 0 0 2 2 2 2 DNL zinc finger PAN_1 PF00024.26 EEA04755.1 - 4.7e-05 23.3 0.6 4.7e-05 23.3 0.6 3.0 3 0 0 3 3 3 1 PAN domain PAN_4 PF14295.6 EEA04755.1 - 0.00042 20.2 0.8 0.00042 20.2 0.8 3.1 3 0 0 3 3 3 1 PAN domain PAN_3 PF08277.12 EEA04755.1 - 0.022 14.6 11.9 0.19 11.6 1.5 2.8 2 0 0 2 2 2 0 PAN-like domain CarbpepA_inh PF02977.15 EEA04755.1 - 0.31 10.8 7.5 1.1 9.2 0.7 2.8 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor PAN_2 PF08276.11 EEA04755.1 - 1.6 8.9 5.6 3.8 7.7 1.7 3.0 2 1 1 3 3 3 0 PAN-like domain TPT PF03151.16 EEA04756.1 - 6e-17 61.9 19.3 7.5e-17 61.6 19.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA04756.1 - 2.8e-05 24.3 26.3 0.0011 19.1 10.2 2.4 2 1 0 2 2 2 2 EamA-like transporter family DUF1449 PF07290.11 EEA04756.1 - 0.28 10.8 4.1 2.6 7.6 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1449) Form-deh_trans PF09163.11 EEA04756.1 - 9.1 6.2 6.1 5.5 6.9 0.0 2.8 3 0 0 3 3 3 0 Formate dehydrogenase N, transmembrane TPT PF03151.16 EEA04757.1 - 2.2e-11 43.7 14.5 3.4e-11 43.0 14.5 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA04757.1 - 0.0038 17.4 6.5 0.0038 17.4 6.5 3.0 3 2 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 EEA04757.1 - 0.026 13.8 16.6 0.28 10.4 8.4 2.8 1 1 1 2 2 2 0 Purine nucleobase transmembrane transport TMEM234 PF10639.9 EEA04757.1 - 0.16 12.0 6.0 0.046 13.8 1.4 2.3 2 1 0 2 2 2 0 Putative transmembrane family 234 TPT PF03151.16 EEA04758.1 - 5e-16 58.9 23.4 6.5e-16 58.5 23.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA04758.1 - 9.6e-09 35.5 28.3 5.1e-05 23.5 12.9 2.3 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 EEA04758.1 - 0.058 12.6 24.6 0.98 8.6 24.4 2.4 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport DUF996 PF06195.13 EEA04759.1 - 0.16 12.2 8.0 2.7 8.3 8.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF996) DUF1500 PF07389.12 EEA04760.1 - 1.8 8.7 4.1 0.74 9.9 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1500) Aa_trans PF01490.18 EEA04761.1 - 1.5e-15 56.8 48.2 2.6e-12 46.2 32.7 2.6 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein GSHPx PF00255.19 EEA04762.1 - 5.2e-25 87.1 0.1 8.4e-25 86.4 0.1 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EEA04762.1 - 3.5e-05 23.7 0.0 6.4e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EEA04762.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 Redoxin MapZ_EC1 PF18041.1 EEA04762.1 - 0.096 12.9 0.2 0.17 12.1 0.2 1.3 1 0 0 1 1 1 0 MapZ extracellular domain 1 LisH PF08513.11 EEA04763.1 - 7.4e-06 25.7 0.2 1.4e-05 24.8 0.2 1.5 1 0 0 1 1 1 1 LisH LisH_2 PF16045.5 EEA04763.1 - 1.1e-05 24.4 2.2 2.1e-05 23.4 2.2 1.5 1 0 0 1 1 1 1 LisH FOP_dimer PF09398.10 EEA04763.1 - 0.00043 20.5 1.6 0.0022 18.2 1.3 2.2 1 1 0 1 1 1 1 FOP N terminal dimerisation domain mRNA_triPase PF02940.15 EEA04764.1 - 1.8e-21 76.9 0.7 1.8e-21 76.9 0.7 1.5 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain DUF4464 PF14713.6 EEA04764.1 - 0.017 14.7 0.1 0.027 14.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4464) FSA_C PF10479.9 EEA04765.1 - 0.84 7.7 28.0 1.3 7.0 28.0 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3533 PF12051.8 EEA04765.1 - 6.3 5.6 16.6 11 4.9 16.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) SRCR_2 PF15494.6 EEA04765.1 - 9.1 6.9 7.8 51 4.5 0.1 4.1 4 0 0 4 4 4 0 Scavenger receptor cysteine-rich domain VPS13_C PF16909.5 EEA04766.1 - 7.4e-59 198.5 16.8 3.4e-58 196.3 1.3 3.9 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EEA04766.1 - 1.4e-21 76.7 1.4 2.8e-20 72.6 0.6 3.7 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EEA04766.1 - 1.5e-18 67.5 0.3 4.3e-17 62.7 0.3 3.0 1 1 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal ATG_C PF09333.11 EEA04766.1 - 6.6e-07 29.6 0.2 2.5e-06 27.7 0.1 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Sec1 PF00995.23 EEA04767.1 - 6e-10 39.0 9.5 2.4e-05 23.8 3.4 2.5 2 0 0 2 2 2 2 Sec1 family ABC_membrane PF00664.23 EEA04768.1 - 5e-29 101.8 35.0 7.7e-21 75.0 17.4 3.6 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EEA04768.1 - 1.5e-23 83.8 0.0 1.2e-12 48.5 0.0 3.1 3 0 0 3 3 2 2 ABC transporter AAA_29 PF13555.6 EEA04768.1 - 1e-08 34.8 1.2 0.0055 16.4 0.0 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA04768.1 - 1.4e-06 28.3 0.5 0.0027 17.7 0.2 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA04768.1 - 5.8e-06 26.3 0.1 0.087 12.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 EEA04768.1 - 0.00015 20.9 0.2 0.13 11.3 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 EEA04768.1 - 0.00021 21.7 0.0 1.1 9.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 EEA04768.1 - 0.00047 19.7 0.6 0.73 9.2 0.1 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 EEA04768.1 - 0.00085 19.3 0.0 1.1 9.2 0.0 2.7 2 0 0 2 2 2 2 NTPase NACHT PF05729.12 EEA04768.1 - 0.00095 19.1 0.6 0.66 9.9 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EEA04768.1 - 0.0013 19.0 0.3 1.3 9.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EEA04768.1 - 0.0029 16.8 0.2 1.7 7.8 0.0 2.7 2 0 0 2 2 2 2 NB-ARC domain AAA_21 PF13304.6 EEA04768.1 - 0.0041 17.0 16.5 0.023 14.5 0.2 5.0 6 0 0 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 EEA04768.1 - 0.0079 15.6 0.2 0.44 9.9 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_18 PF13238.6 EEA04768.1 - 0.012 16.2 0.2 7.5 7.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EEA04768.1 - 0.014 15.0 1.3 2.5 7.7 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EEA04768.1 - 0.018 14.8 0.0 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EEA04768.1 - 0.02 15.4 0.2 0.02 15.4 0.2 4.1 4 0 0 4 4 3 0 AAA domain RNA_helicase PF00910.22 EEA04768.1 - 0.021 15.2 0.0 3.7 8.0 0.0 2.8 2 0 0 2 2 2 0 RNA helicase MobB PF03205.14 EEA04768.1 - 0.026 14.4 0.1 4.2 7.3 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 EEA04768.1 - 0.031 13.8 0.1 7.5 6.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 EEA04768.1 - 0.053 13.6 0.2 0.053 13.6 0.2 3.1 3 0 0 3 3 2 0 Dynamin family DUF2075 PF09848.9 EEA04768.1 - 0.063 12.5 0.2 0.7 9.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 EEA04768.1 - 0.1 12.1 0.0 2.3 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EEA04768.1 - 0.18 12.1 0.1 12 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EEA04768.1 - 0.23 10.7 0.1 10 5.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 EEA04768.1 - 0.24 11.6 0.3 14 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EEA04768.1 - 1.4 8.9 10.2 0.36 10.9 0.2 3.5 3 0 0 3 3 3 0 Helicase HerA, central domain Telomere_reg-2 PF10193.9 EEA04769.1 - 0.024 15.1 0.2 0.12 12.8 0.2 2.3 1 0 0 1 1 1 0 Telomere length regulation protein DEAD PF00270.29 EEA04770.1 - 1.4e-18 67.3 0.0 6.5e-18 65.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA04770.1 - 2.2e-14 53.7 0.4 1.3e-13 51.3 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA04770.1 - 1.4e-07 31.7 0.0 5e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EEA04770.1 - 4.7e-05 24.0 4.2 0.00025 21.7 4.2 2.3 1 1 0 1 1 1 1 RecQ zinc-binding Herpes_TK PF00693.18 EEA04772.1 - 0.18 11.0 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Thymidine kinase from herpesvirus CAF1 PF04857.20 EEA04773.1 - 3.9e-27 95.3 7.2 5e-14 52.2 0.9 2.4 2 1 0 2 2 2 2 CAF1 family ribonuclease RNase_T PF00929.24 EEA04773.1 - 0.074 13.6 0.0 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 Exonuclease adh_short PF00106.25 EEA04775.1 - 1.9e-38 131.9 0.0 2.5e-38 131.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA04775.1 - 4.6e-34 118.0 0.0 6.3e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA04775.1 - 2.3e-05 24.0 0.0 4e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EEA04775.1 - 5.5e-05 23.1 0.1 0.00031 20.7 0.1 2.1 2 1 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 EEA04775.1 - 7.7e-05 21.8 0.3 0.00013 21.1 0.2 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EEA04775.1 - 0.0021 17.2 0.3 0.008 15.4 0.3 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EEA04775.1 - 0.0035 16.8 0.0 0.006 16.0 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NMT PF01233.19 EEA04776.1 - 5.1e-64 214.9 0.2 1.4e-63 213.5 0.1 1.9 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EEA04776.1 - 1.6e-51 174.8 3.0 1.5e-38 132.5 1.4 3.1 2 1 1 3 3 3 2 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 EEA04776.1 - 0.00024 21.2 0.0 0.0034 17.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA04776.1 - 0.00033 20.9 0.0 0.0007 19.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family RCC1 PF00415.18 EEA04777.1 - 1.1e-105 346.1 53.9 7.3e-14 52.1 0.4 14.4 15 1 0 15 15 15 12 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA04777.1 - 1.5e-43 145.8 90.7 3.7e-07 29.8 1.0 14.6 14 1 0 14 14 14 11 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EEA04777.1 - 0.38 11.0 1.2 3.4 8.0 0.0 3.2 2 2 1 3 3 3 0 Putative heavy-metal chelation NTF2 PF02136.20 EEA04778.1 - 7.7e-10 39.4 0.1 2.1e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain Glyco_hydro_63N PF16923.5 EEA04778.1 - 0.11 12.6 1.2 0.19 11.8 0.0 2.0 2 1 0 2 2 2 0 Glycosyl hydrolase family 63 N-terminal domain NUDIX PF00293.28 EEA04779.1 - 7.7e-13 48.6 0.0 1.2e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain KCH PF16944.5 EEA04779.1 - 0.024 14.4 0.0 0.033 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal potassium channel DSHCT PF08148.12 EEA04782.1 - 9.3e-43 145.7 0.0 2.1e-42 144.6 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EEA04782.1 - 9.1e-20 71.1 0.0 4.3e-19 68.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase MNNL PF07657.13 EEA04783.1 - 0.014 15.4 2.4 0.058 13.4 2.4 2.0 1 0 0 1 1 1 0 N terminus of Notch ligand Pkinase PF00069.25 EEA04784.1 - 1.7e-64 217.7 0.0 1e-33 116.8 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA04784.1 - 2.1e-28 99.3 0.0 1e-17 64.3 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase EF-hand_6 PF13405.6 EEA04784.1 - 7.8e-11 41.0 0.7 0.023 14.6 0.1 5.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EEA04784.1 - 1.6e-05 25.3 3.6 0.081 13.4 0.4 4.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA04784.1 - 1.7e-05 24.1 2.6 0.0037 16.7 0.2 4.1 4 0 0 4 4 4 1 EF hand EF-hand_1 PF00036.32 EEA04784.1 - 2.3e-05 23.6 6.9 0.0028 17.1 0.1 5.2 5 0 0 5 5 5 1 EF hand Kdo PF06293.14 EEA04784.1 - 0.093 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA04784.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF262 PF03235.14 EEA04784.1 - 0.19 11.9 0.1 0.19 11.9 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function DUF262 EF-hand_8 PF13833.6 EEA04784.1 - 0.25 11.2 4.5 16 5.5 0.1 4.7 5 0 0 5 5 5 0 EF-hand domain pair Metallophos PF00149.28 EEA04785.1 - 3.6e-30 106.0 0.2 6.9e-30 105.1 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_5 PF13854.6 EEA04785.1 - 3.3e-28 97.2 1.7 1.8e-05 24.6 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EEA04785.1 - 2.7e-22 78.5 10.9 1.2e-09 38.1 0.4 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EEA04785.1 - 1.2e-17 63.1 2.2 0.00076 19.4 0.0 5.9 4 1 1 5 5 5 5 Kelch motif Kelch_3 PF13415.6 EEA04785.1 - 3e-14 52.9 11.8 9.6e-06 25.8 0.1 6.0 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EEA04785.1 - 7.6e-12 44.6 0.7 0.00062 19.3 0.0 5.3 5 1 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 EEA04785.1 - 2.5e-09 37.1 8.6 0.67 10.3 0.0 6.3 3 2 3 6 6 6 4 Kelch motif RAG2 PF03089.14 EEA04785.1 - 0.00015 20.9 0.0 0.33 9.9 0.0 2.3 2 0 0 2 2 2 2 Recombination activating protein 2 PGAP1 PF07819.13 EEA04786.1 - 0.21 11.3 1.8 0.32 10.7 0.6 1.9 2 1 0 2 2 2 0 PGAP1-like protein PPP4R2 PF09184.11 EEA04787.1 - 0.00017 21.3 5.2 0.0026 17.4 2.9 2.5 2 0 0 2 2 2 2 PPP4R2 ORC5_C PF14630.6 EEA04787.1 - 0.074 12.6 0.2 0.1 12.1 0.2 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus eIF3_p135 PF12807.7 EEA04788.1 - 2e-06 28.0 0.0 6e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EEA04788.1 - 9.9e-06 25.8 0.3 0.41 11.0 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA04788.1 - 0.0052 16.8 0.2 1.3 9.3 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA04788.1 - 0.057 13.3 0.4 8.4 6.4 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EEA04788.1 - 0.088 12.7 0.1 2.4 8.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat US6 PF17616.2 EEA04788.1 - 0.1 12.6 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Viral unique short region 6 TPR_8 PF13181.6 EEA04788.1 - 0.1 12.8 0.2 1.2 9.6 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Hydantoinase_A PF01968.18 EEA04790.1 - 0.16 11.2 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase zf-CCCH PF00642.24 EEA04791.1 - 3.2e-07 30.1 0.5 6.9e-07 29.0 0.5 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EEA04791.1 - 3.6e-07 29.8 2.4 8.7e-07 28.6 2.4 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EEA04791.1 - 1.9e-06 27.7 5.0 4.5e-06 26.5 5.0 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 EEA04791.1 - 0.025 15.0 3.3 0.073 13.6 3.3 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger PelG PF16933.5 EEA04791.1 - 0.075 11.9 0.1 0.12 11.2 0.1 1.3 1 0 0 1 1 1 0 Putative exopolysaccharide Exporter (EPS-E) EGF_CA PF07645.15 EEA04792.1 - 0.0001 22.4 23.2 0.00013 22.1 5.6 2.4 2 0 0 2 2 2 2 Calcium-binding EGF domain EGF_3 PF12947.7 EEA04792.1 - 0.00066 19.8 9.0 0.00066 19.8 9.0 2.4 2 0 0 2 2 2 1 EGF domain cEGF PF12662.7 EEA04792.1 - 0.01 15.7 4.1 0.031 14.2 4.1 1.9 1 0 0 1 1 1 0 Complement Clr-like EGF-like hEGF PF12661.7 EEA04792.1 - 1.6 9.5 10.6 0.073 13.7 1.4 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF Sec20 PF03908.13 EEA04793.1 - 0.00012 21.9 2.8 0.00012 21.9 2.8 2.5 2 1 0 2 2 2 1 Sec20 V-SNARE_C PF12352.8 EEA04793.1 - 0.036 14.3 4.3 0.32 11.3 1.0 2.4 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Glyco_transf_28 PF03033.20 EEA04793.1 - 0.045 13.8 0.1 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain Guanylin PF02058.15 EEA04793.1 - 0.091 13.2 0.1 0.16 12.4 0.1 1.5 1 0 0 1 1 1 0 Guanylin precursor YfdX PF10938.8 EEA04793.1 - 0.096 12.6 0.4 0.85 9.5 0.4 2.0 1 1 0 1 1 1 0 YfdX protein Synaptobrevin PF00957.21 EEA04793.1 - 4.5 7.1 11.8 4.1 7.3 0.8 2.9 3 0 0 3 3 3 0 Synaptobrevin RRP36 PF06102.12 EEA04794.1 - 5.5e-26 91.5 20.5 6.8e-26 91.2 20.5 1.1 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 DUF4337 PF14235.6 EEA04795.1 - 0.53 10.4 7.2 1.1 9.4 7.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MukB PF04310.12 EEA04795.1 - 9.8 5.9 7.2 3.5 7.4 2.4 2.4 2 1 1 3 3 3 0 MukB N-terminal HEAT PF02985.22 EEA04797.1 - 0.00015 21.8 1.1 1.6 9.2 0.1 5.5 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EEA04797.1 - 0.00054 20.4 0.0 0.0017 18.8 0.0 1.9 1 0 0 1 1 1 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EEA04797.1 - 0.04 14.5 12.4 1.1 9.9 0.6 5.0 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region Phage_TAC_5 PF08890.11 EEA04797.1 - 0.071 13.1 0.5 0.2 11.7 0.5 1.8 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC MscL PF01741.18 EEA04797.1 - 6.7 7.0 11.0 3.3 8.0 0.6 3.8 4 1 0 4 4 4 0 Large-conductance mechanosensitive channel, MscL MMR_HSR1_Xtn PF16897.5 EEA04798.1 - 2.7e-42 143.1 2.7 5.5e-42 142.1 2.7 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EEA04798.1 - 3.1e-19 69.1 0.0 6.6e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EEA04798.1 - 7.3e-15 54.8 0.1 1.3e-14 53.9 0.1 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EEA04798.1 - 4.4e-11 42.5 0.0 1.1e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA04798.1 - 3.9e-05 23.8 0.2 0.00036 20.6 0.2 2.3 1 1 0 1 1 1 1 Dynamin family Arf PF00025.21 EEA04798.1 - 0.055 12.9 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 EEA04798.1 - 0.087 13.0 0.1 2.8 8.2 0.0 2.8 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Spindle_Spc25 PF08234.12 EEA04799.1 - 1.8e-16 60.1 1.0 1.8e-16 60.1 1.0 2.3 3 0 0 3 3 3 1 Chromosome segregation protein Spc25 Apolipoprotein PF01442.18 EEA04799.1 - 0.005 16.7 2.5 0.0093 15.9 2.5 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 EEA04799.1 - 0.0096 15.5 3.7 0.013 15.1 3.7 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit ARA70 PF12489.8 EEA04799.1 - 0.026 14.7 1.4 0.088 13.0 1.2 1.9 2 0 0 2 2 2 0 Nuclear coactivator Allexi_40kDa PF05549.11 EEA04799.1 - 0.027 14.0 2.8 0.047 13.2 2.8 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein Spectrin_like PF18373.1 EEA04799.1 - 0.068 13.3 2.4 0.34 11.0 1.9 2.3 2 0 0 2 2 2 0 Spectrin like domain HAUS4 PF14735.6 EEA04799.1 - 0.078 12.7 5.7 0.13 12.0 5.2 1.5 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 OmpH PF03938.14 EEA04799.1 - 0.12 12.7 5.0 0.17 12.2 3.6 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF5082 PF16888.5 EEA04799.1 - 0.24 11.7 13.0 1.2 9.4 4.7 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) Ax_dynein_light PF10211.9 EEA04799.1 - 0.89 9.5 13.0 0.86 9.5 8.3 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain KIP1 PF07765.12 EEA04799.1 - 1.2 9.3 8.8 3.4 7.9 2.0 2.8 2 1 1 3 3 3 0 KIP1-like protein Noelin-1 PF12308.8 EEA04799.1 - 2 8.5 8.2 5.2 7.1 2.5 2.7 2 1 1 3 3 3 0 Neurogenesis glycoprotein Rootletin PF15035.6 EEA04799.1 - 2.4 8.1 13.8 0.72 9.9 11.1 1.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.6 EEA04799.1 - 3.1 7.1 5.0 5.1 6.4 3.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Asn_synthase PF00733.21 EEA04800.1 - 9.5e-09 35.4 0.0 0.19 11.3 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase TK PF00265.18 EEA04803.1 - 6.9e-58 195.4 1.7 7.7e-58 195.2 1.7 1.0 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.6 EEA04803.1 - 0.0062 16.6 0.2 0.0093 16.0 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA04803.1 - 0.053 13.8 0.3 0.1 12.9 0.3 1.4 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EEA04803.1 - 0.56 10.1 3.2 16 5.3 3.2 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TSP_1 PF00090.19 EEA04805.1 - 1.1e-21 76.8 39.0 6.8e-11 42.2 5.7 3.5 3 0 0 3 3 3 3 Thrombospondin type 1 domain EGF PF00008.27 EEA04805.1 - 0.0005 20.3 6.0 0.0005 20.3 6.0 2.6 3 0 0 3 3 3 1 EGF-like domain Chorein_N PF12624.7 EEA04806.1 - 1.1e-28 99.6 1.3 1.1e-27 96.5 0.2 3.3 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EEA04806.1 - 7.4e-08 32.5 1.6 7.4e-08 32.5 1.6 4.0 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal ATG_C PF09333.11 EEA04806.1 - 7.8e-07 29.4 0.0 3e-06 27.5 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EEA04806.1 - 7.4e-05 22.6 1.1 1.3 8.7 0.0 4.3 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal CdiA_C_tRNase PF18664.1 EEA04806.1 - 0.12 12.5 2.7 0.8 9.9 2.7 2.4 1 0 0 1 1 1 0 CdiA C-terminal tRNase domain Cullin PF00888.22 EEA04807.1 - 1.1e-21 77.2 15.5 7.8e-08 31.4 0.2 4.2 4 0 0 4 4 4 3 Cullin family Cullin_Nedd8 PF10557.9 EEA04807.1 - 5.4e-06 26.4 1.1 2e-05 24.5 1.1 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain Acetyltransf_1 PF00583.25 EEA04808.1 - 2.1e-10 40.8 0.0 2.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA04808.1 - 3.8e-07 30.4 0.0 5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA04808.1 - 1.5e-05 25.0 0.1 1.9e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA04808.1 - 0.0023 17.9 0.0 0.0031 17.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA04808.1 - 0.03 14.4 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain E_raikovi_mat PF06360.11 EEA04808.1 - 0.062 13.7 0.7 0.15 12.5 0.4 1.8 2 0 0 2 2 2 0 Euplotes raikovi mating pheromone COesterase PF00135.28 EEA04810.1 - 6.2e-63 213.4 0.4 8.7e-62 209.6 0.4 2.2 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EEA04810.1 - 3.5e-10 40.1 0.1 1.3e-09 38.3 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1749 PF08538.10 EEA04810.1 - 0.0036 16.4 0.0 0.0065 15.6 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.21 EEA04810.1 - 0.04 13.4 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ser_hydrolase PF06821.13 EEA04810.1 - 0.084 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_6 PF12697.7 EEA04810.1 - 0.11 13.0 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3446 PF11928.8 EEA04810.1 - 0.75 10.1 6.8 0.31 11.3 1.6 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain zf_PR_Knuckle PF18445.1 EEA04811.1 - 0.86 9.5 3.4 11 5.9 0.7 2.6 2 0 0 2 2 2 0 PR zinc knuckle motif p25-alpha PF05517.12 EEA04812.1 - 4.4e-09 36.7 0.3 9.7e-09 35.6 0.1 1.6 1 1 0 1 1 1 1 p25-alpha DCX PF03607.17 EEA04812.1 - 4.5e-07 29.9 0.0 9.7e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Doublecortin HopA1 PF17914.1 EEA04812.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 HopA1 effector protein family Ribosomal_S7e PF01251.18 EEA04813.1 - 5.5e-59 199.0 0.1 6.2e-59 198.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e IL17R_D_N PF16742.5 EEA04813.1 - 0.092 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D Plus-3 PF03126.18 EEA04815.1 - 7.6e-15 55.4 0.3 4.4e-14 52.9 0.0 2.5 2 0 0 2 2 2 1 Plus-3 domain Phage_int_SAM_2 PF12834.7 EEA04815.1 - 0.59 10.9 3.9 19 6.0 0.3 2.5 2 0 0 2 2 2 0 Phage integrase, N-terminal CS PF04969.16 EEA04816.1 - 1.3e-09 39.0 2.6 3.3e-09 37.6 2.6 1.6 1 1 0 1 1 1 1 CS domain PUF PF00806.19 EEA04817.1 - 9.5e-09 34.5 9.1 0.013 15.1 0.1 6.1 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat DsrD PF08679.11 EEA04817.1 - 0.038 14.3 0.1 0.22 11.8 0.1 2.4 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) MMADHC PF10229.9 EEA04817.1 - 0.12 12.1 0.7 0.22 11.2 0.7 1.3 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein Sec63 PF02889.16 EEA04818.1 - 1.1e-88 296.8 10.5 1.1e-55 188.7 0.1 2.7 2 0 0 2 2 2 2 Sec63 Brl domain Helicase_PWI PF18149.1 EEA04818.1 - 5e-35 120.0 2.8 2.3e-34 117.9 2.8 2.3 1 0 0 1 1 1 1 N-terminal helicase PWI domain DEAD PF00270.29 EEA04818.1 - 5.9e-28 97.8 0.0 4.2e-23 82.0 0.1 3.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EEA04818.1 - 1.8e-10 41.1 0.0 8.1e-10 39.0 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA04818.1 - 9.5e-10 38.8 3.8 1e-05 25.8 0.1 4.7 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA04818.1 - 0.0067 16.7 0.8 0.23 11.7 0.6 3.2 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EEA04818.1 - 0.048 14.1 0.8 0.41 11.1 0.2 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EEA04818.1 - 0.12 11.4 0.0 0.25 10.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD-helicase PF00580.21 EEA04818.1 - 0.38 10.2 12.2 3.2 7.2 0.0 3.9 4 0 0 4 4 4 0 UvrD/REP helicase N-terminal domain DnaJ PF00226.31 EEA04819.1 - 1e-23 83.2 0.2 4.1e-23 81.3 0.2 2.2 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 EEA04819.1 - 2.7e-09 37.1 3.0 2.7e-09 37.1 3.0 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA04819.1 - 3.3e-09 36.8 4.3 3.3e-09 36.8 4.3 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EEA04819.1 - 1.1e-06 28.9 15.9 0.0031 17.8 1.1 3.5 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EEA04819.1 - 1.3e-05 25.7 5.1 0.042 14.7 0.8 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger VAPB_antitox PF02697.14 EEA04819.1 - 0.0061 17.3 3.8 0.0061 17.3 3.8 3.3 2 1 1 3 3 3 1 Putative antitoxin zf-C2H2 PF00096.26 EEA04819.1 - 0.0071 16.7 8.0 0.27 11.8 2.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EEA04819.1 - 0.058 14.1 8.9 3.1 8.5 1.2 3.5 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-UBP PF02148.19 EEA04819.1 - 0.075 13.4 1.3 0.3 11.4 0.2 2.4 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein zf-DBF PF07535.12 EEA04819.1 - 0.63 10.2 4.0 0.33 11.1 0.6 2.3 2 0 0 2 2 2 0 DBF zinc finger VPS11_C PF12451.8 EEA04819.1 - 1.2 9.5 4.1 1.4 9.2 0.3 3.1 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal zf-C2H2_6 PF13912.6 EEA04819.1 - 2.8 8.0 5.0 6.6 6.9 1.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger FHA PF00498.26 EEA04820.1 - 4.2e-16 59.0 0.8 4.2e-16 59.0 0.8 2.1 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EEA04820.1 - 0.0065 16.8 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Rho_RNA_bind PF07497.12 EEA04820.1 - 0.018 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Rho termination factor, RNA-binding domain DNA_pol_phi PF04931.13 EEA04821.1 - 4.3e-11 41.7 0.0 4.3e-11 41.7 0.0 3.8 4 0 0 4 4 4 3 DNA polymerase phi FANCI_S2 PF14676.6 EEA04821.1 - 0.1 12.9 2.4 6.6 7.0 0.2 3.5 3 1 0 3 3 3 0 FANCI solenoid 2 SNF2_N PF00176.23 EEA04822.1 - 1e-46 159.3 0.7 2.8e-45 154.6 0.7 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA04822.1 - 3.2e-20 72.5 0.0 4.1e-19 69.0 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EEA04822.1 - 4.9e-08 32.5 0.1 1.1e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EEA04822.1 - 1.8e-07 31.3 0.0 1.8e-07 31.3 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EEA04822.1 - 0.00093 18.2 0.0 0.0055 15.6 0.0 2.0 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 SWI2_SNF2 PF18766.1 EEA04822.1 - 0.014 15.0 0.0 0.038 13.7 0.0 1.7 1 1 0 1 1 1 0 SWI2/SNF2 ATPase Alpha-amylase PF00128.24 EEA04823.1 - 1.8e-53 182.3 0.2 5.4e-52 177.4 0.2 2.2 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EEA04823.1 - 0.00052 20.1 0.0 0.025 14.7 0.0 2.4 2 0 0 2 2 2 1 Maltogenic Amylase, C-terminal domain HTH_Tnp_Tc5 PF03221.16 EEA04823.1 - 0.2 11.7 0.8 19 5.4 0.2 3.0 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain PP2C PF00481.21 EEA04824.1 - 1.6e-10 41.1 0.0 0.00024 20.9 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EEA04824.1 - 5.3e-06 26.5 0.0 0.00062 19.7 0.0 2.5 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EEA04824.1 - 8.9e-05 22.2 0.0 0.0077 15.9 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C CLP1_P PF16575.5 EEA04826.1 - 6.8e-28 97.7 0.0 3.3e-23 82.5 0.0 3.1 2 1 1 3 3 3 2 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EEA04826.1 - 1.1e-21 76.8 0.0 2.8e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor CbiA PF01656.23 EEA04826.1 - 0.00062 19.8 0.0 0.0019 18.2 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Clp1 PF06807.14 EEA04826.1 - 0.0017 18.7 0.0 0.0088 16.5 0.0 2.1 2 0 0 2 2 2 1 Pre-mRNA cleavage complex II protein Clp1 MMR_HSR1 PF01926.23 EEA04826.1 - 0.0029 17.7 0.2 0.014 15.4 0.0 2.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EEA04826.1 - 0.0047 16.7 0.2 0.013 15.2 0.0 1.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 EEA04826.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EEA04826.1 - 0.014 15.7 0.3 0.52 10.7 0.0 3.0 2 1 1 3 3 3 0 RNA helicase ABC_tran PF00005.27 EEA04826.1 - 0.02 15.4 0.0 0.047 14.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EEA04826.1 - 0.021 15.2 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EEA04826.1 - 0.036 14.6 0.0 0.083 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Thia_YuaJ PF09515.10 EEA04826.1 - 0.085 12.9 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Thiamine transporter protein (Thia_YuaJ) ATPase PF06745.13 EEA04826.1 - 0.14 11.5 0.0 0.65 9.3 0.0 2.0 2 0 0 2 2 2 0 KaiC APS_kinase PF01583.20 EEA04826.1 - 0.2 11.5 0.0 0.62 9.9 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase zf-CCCH_3 PF15663.5 EEA04827.1 - 0.0047 17.1 1.5 0.0047 17.1 1.5 2.6 2 1 0 3 3 3 1 Zinc-finger containing family zf-CCCH PF00642.24 EEA04827.1 - 0.43 10.5 23.2 0.52 10.3 1.3 5.3 5 0 0 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) APG6_N PF17675.1 EEA04828.1 - 0.0021 18.6 0.7 0.0021 18.6 0.7 3.3 3 0 0 3 3 3 1 Apg6 coiled-coil region Lebercilin PF15619.6 EEA04828.1 - 0.01 15.5 2.3 0.01 15.5 2.3 2.9 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF5371 PF17341.2 EEA04828.1 - 0.069 13.4 1.3 0.18 12.0 1.3 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5371) DUF641 PF04859.12 EEA04828.1 - 0.086 13.2 0.1 0.086 13.2 0.1 3.5 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) ATG16 PF08614.11 EEA04828.1 - 0.13 12.4 21.5 1.9 8.7 1.6 2.9 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EEA04828.1 - 0.54 9.1 30.5 0.24 10.2 1.9 3.3 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 EEA04828.1 - 0.98 9.5 19.5 0.79 9.8 1.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EEA04828.1 - 2.5 8.8 19.0 0.26 11.9 3.0 4.6 3 1 1 4 4 4 0 SlyX GrpE PF01025.19 EEA04828.1 - 3.5 7.3 20.1 0.031 13.9 1.4 3.1 2 1 0 2 2 2 0 GrpE Spectrin PF00435.21 EEA04828.1 - 4.9 7.7 14.7 9.1 6.8 2.0 3.7 3 0 0 3 3 3 0 Spectrin repeat DUF16 PF01519.16 EEA04828.1 - 5.3 7.6 19.7 0.041 14.4 1.0 3.5 2 1 0 2 2 1 0 Protein of unknown function DUF16 PspA_IM30 PF04012.12 EEA04828.1 - 6 6.4 16.9 6.2 6.3 1.6 3.2 2 1 1 3 3 3 0 PspA/IM30 family IL5 PF02025.15 EEA04828.1 - 9.2 6.6 11.2 0.17 12.2 0.3 3.5 4 0 0 4 4 4 0 Interleukin 5 ACT_5 PF13710.6 EEA04829.1 - 0.089 12.6 0.4 0.18 11.7 0.4 1.5 1 0 0 1 1 1 0 ACT domain DHH PF01368.20 EEA04830.1 - 1e-12 48.2 0.0 1.9e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 DHH family DHHA2 PF02833.14 EEA04830.1 - 0.0087 16.3 0.1 0.02 15.1 0.1 1.5 1 0 0 1 1 1 1 DHHA2 domain Chorein_N PF12624.7 EEA04831.1 - 6.5e-16 58.5 0.1 4e-15 56.0 0.0 2.6 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EEA04831.1 - 7.4e-11 42.3 8.7 2.4e-07 30.8 0.2 4.9 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 EEA04831.1 - 1.4e-09 38.0 3.9 5.4e-08 32.8 3.9 3.2 1 1 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal ErmC PF06308.11 EEA04831.1 - 0.14 12.5 0.8 0.48 10.8 0.8 1.9 1 0 0 1 1 1 0 23S rRNA methylastransferase leader peptide (ErmCL) Peptidase_C48 PF02902.19 EEA04833.1 - 1e-38 133.4 4.1 2e-38 132.4 4.1 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Cofilin_ADF PF00241.20 EEA04834.1 - 7.6e-29 100.0 0.1 8.4e-29 99.8 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein AAA PF00004.29 EEA04835.1 - 4.3e-39 134.0 0.0 9.9e-39 132.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA04835.1 - 2.8e-07 30.4 0.0 5.6e-07 29.4 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EEA04835.1 - 3.9e-06 27.1 0.0 9e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA04835.1 - 0.00014 22.1 0.3 0.0018 18.5 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EEA04835.1 - 0.00014 21.8 1.0 0.0029 17.6 0.3 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EEA04835.1 - 0.00024 20.8 0.0 0.00061 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EEA04835.1 - 0.0026 18.2 0.0 0.0091 16.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EEA04835.1 - 0.0035 16.7 0.1 0.0079 15.6 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EEA04835.1 - 0.0039 17.1 0.7 0.014 15.3 0.0 2.3 3 0 0 3 3 3 1 NACHT domain TIP49 PF06068.13 EEA04835.1 - 0.0044 16.3 0.0 0.014 14.6 0.0 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_18 PF13238.6 EEA04835.1 - 0.0049 17.4 0.1 0.024 15.2 0.0 2.3 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EEA04835.1 - 0.0069 16.0 0.2 0.13 11.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA04835.1 - 0.0073 16.1 0.1 0.018 14.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EEA04835.1 - 0.01 15.8 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EEA04835.1 - 0.019 14.1 0.2 0.3 10.2 0.0 2.6 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 EEA04835.1 - 0.025 14.6 0.1 0.14 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA04835.1 - 0.04 13.7 0.0 0.089 12.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EEA04835.1 - 0.04 14.1 0.0 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA04835.1 - 0.049 14.0 0.0 0.14 12.6 0.0 1.9 1 1 0 1 1 1 0 RNA helicase Vps4_C PF09336.10 EEA04835.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Zot PF05707.12 EEA04835.1 - 0.17 11.5 0.2 0.92 9.1 0.1 2.0 1 1 1 2 2 2 0 Zonular occludens toxin (Zot) ABC_tran PF00005.27 EEA04835.1 - 0.26 11.8 1.4 1 9.9 0.0 2.5 2 1 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 EEA04835.1 - 0.73 9.7 2.6 3.5 7.5 0.0 3.1 4 1 1 5 5 4 0 NTPase RasGEF_N PF00618.20 EEA04835.1 - 2.3 8.5 5.4 1.9 8.8 2.2 2.6 1 1 2 3 3 3 0 RasGEF N-terminal motif S10_plectin PF03501.15 EEA04836.1 - 1.7e-39 133.8 0.3 2e-39 133.6 0.3 1.0 1 0 0 1 1 1 1 Plectin/S10 domain Arf PF00025.21 EEA04837.1 - 3.4e-15 55.9 0.0 6.4e-15 55.0 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 EEA04837.1 - 5.7e-08 32.4 0.2 1.1e-07 31.5 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EEA04837.1 - 2.3e-06 27.8 0.0 6.5e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EEA04837.1 - 0.00011 21.8 0.2 0.0002 21.0 0.0 1.5 2 0 0 2 2 2 1 Ras family Gtr1_RagA PF04670.12 EEA04837.1 - 0.00037 19.9 0.0 0.00065 19.1 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA04837.1 - 0.00043 20.4 0.0 0.00085 19.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EEA04837.1 - 0.0013 18.5 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EEA04837.1 - 0.0019 17.3 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 EEA04837.1 - 0.0067 16.1 0.3 0.013 15.2 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.6 EEA04837.1 - 0.0075 16.3 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EEA04837.1 - 0.023 15.2 6.1 0.13 12.7 1.3 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EEA04837.1 - 0.052 13.1 0.0 0.081 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 EEA04837.1 - 0.08 12.5 0.4 0.2 11.3 0.2 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EEA04837.1 - 0.088 13.2 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EEA04837.1 - 0.18 11.9 0.2 0.26 11.4 0.2 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EEA04837.1 - 0.44 11.0 1.7 0.62 10.6 0.2 1.9 2 0 0 2 2 2 0 ABC transporter Pox_A3L PF05288.11 EEA04838.1 - 0.073 13.1 0.8 0.15 12.0 0.1 2.0 2 0 0 2 2 2 0 Poxvirus A3L Protein zf-C2H2_12 PF18658.1 EEA04843.1 - 0.012 15.2 0.1 0.031 13.8 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger C2H2-type MRAP PF15183.6 EEA04846.1 - 0.11 12.5 0.7 0.53 10.3 0.7 2.2 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family EI24 PF07264.11 EEA04847.1 - 0.017 15.4 0.1 0.026 14.8 0.1 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) ADH_N PF08240.12 EEA04848.1 - 2.7e-25 88.4 3.4 4.4e-25 87.7 3.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EEA04848.1 - 1.7e-13 50.7 1.4 3.1e-13 49.8 0.3 2.0 2 1 1 3 3 3 1 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 EEA04848.1 - 0.0074 16.5 0.1 0.018 15.2 0.1 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EEA04848.1 - 0.0092 15.3 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EEA04848.1 - 0.011 16.8 0.0 0.048 14.7 0.0 2.0 2 0 0 2 2 2 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EEA04848.1 - 0.018 14.4 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EEA04848.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Imm26 PF15428.6 EEA04849.1 - 0.38 11.0 2.4 18 5.6 0.4 2.9 3 0 0 3 3 3 0 Immunity protein 26 zf-RanBP PF00641.18 EEA04850.1 - 0.0026 17.0 5.4 0.0026 17.0 5.4 2.5 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others DUF241 PF03087.14 EEA04851.1 - 0.5 10.2 6.4 0.6 9.9 6.4 1.5 1 1 0 1 1 1 0 Arabidopsis protein of unknown function PUF PF00806.19 EEA04852.1 - 0.01 15.5 0.1 0.4 10.5 0.1 3.7 3 0 0 3 3 3 0 Pumilio-family RNA binding repeat DUF1981 PF09324.10 EEA04852.1 - 0.01 15.6 2.3 0.12 12.3 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) His_Phos_1 PF00300.22 EEA04853.1 - 9.7e-29 100.5 0.5 1.6e-28 99.7 0.5 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_M17 PF00883.21 EEA04854.1 - 2.5e-97 325.9 0.0 3.1e-97 325.6 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DUF4516 PF14990.6 EEA04854.1 - 0.21 11.3 0.8 0.6 9.9 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4516) Swm2 PF17083.5 EEA04855.1 - 0.0039 17.2 3.0 0.0063 16.5 3.0 1.3 1 0 0 1 1 1 1 Nucleolar protein Swm2 DUF2719 PF10891.8 EEA04855.1 - 0.011 15.6 0.1 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2719) PYRIN PF02758.16 EEA04855.1 - 0.04 14.1 0.4 0.52 10.5 0.0 2.5 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Mlh1_C PF16413.5 EEA04856.1 - 2e-42 145.4 2.3 6.3e-42 143.8 2.3 1.9 1 1 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EEA04856.1 - 1.2e-19 70.1 5.1 2.6e-19 69.1 1.1 2.7 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EEA04856.1 - 1e-11 44.8 0.0 3.7e-11 43.0 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EEA04856.1 - 9.9e-06 26.0 0.0 2.8e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ubiquitin PF00240.23 EEA04857.1 - 6.9e-71 234.0 4.2 1.1e-34 117.9 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EEA04857.1 - 9.4e-35 118.3 4.6 1.2e-16 60.3 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA04857.1 - 6.2e-14 52.2 0.8 3.1e-05 24.3 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA04857.1 - 1.8e-08 34.2 0.3 0.0068 16.3 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EEA04857.1 - 5.2e-08 33.1 0.2 0.013 15.8 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA04857.1 - 6.1e-08 32.8 0.3 0.02 15.0 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EEA04857.1 - 7e-06 26.5 0.0 0.17 12.4 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EEA04857.1 - 4.8e-05 23.3 6.8 9.2 6.4 0.0 4.0 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EEA04857.1 - 0.0002 21.2 0.0 0.58 10.0 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 EEA04857.1 - 0.013 15.9 0.1 11 6.5 0.0 2.8 2 2 2 4 4 4 0 Protein of unknown function (DUF2870) RBD PF02196.15 EEA04857.1 - 0.028 14.5 0.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Raf-like Ras-binding domain FERM_f0 PF16511.5 EEA04857.1 - 0.046 14.0 2.0 32 4.9 0.1 3.7 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM DUF3861 PF12977.7 EEA04857.1 - 0.046 13.9 0.1 11 6.2 0.0 2.2 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) FlgD_ig PF13860.6 EEA04857.1 - 0.11 12.4 0.5 21 5.1 0.1 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain TmoB PF06234.12 EEA04857.1 - 0.11 12.6 0.3 25 5.0 0.0 2.7 2 2 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) UDP-g_GGTase PF06427.11 EEA04857.1 - 0.14 12.3 0.5 1.6 8.9 0.0 2.4 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EEA04857.1 - 0.15 11.5 0.0 6.4 6.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF969) WD40 PF00400.32 EEA04858.1 - 4.8e-11 43.0 28.7 9.4e-06 26.3 0.2 9.8 11 0 0 11 11 11 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA04858.1 - 2.2e-05 24.7 1.6 2.8 8.3 0.2 5.5 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain SdiA-regulated PF06977.11 EEA04858.1 - 0.093 11.9 0.0 0.26 10.5 0.0 1.7 1 0 0 1 1 1 0 SdiA-regulated CECR6_TMEM121 PF14997.6 EEA04859.1 - 1.2e-12 48.1 6.2 3.4e-12 46.6 6.2 1.8 1 0 0 1 1 1 1 CECR6/TMEM121 family Med6 PF04934.14 EEA04860.1 - 1.1e-22 80.3 0.0 1.6e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component Pkinase PF00069.25 EEA04861.1 - 1.1e-77 261.0 0.0 1.2e-77 260.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA04861.1 - 2.4e-34 118.8 0.0 3.5e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA04861.1 - 4.8e-05 23.4 0.6 0.015 15.3 0.3 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EEA04861.1 - 5.8e-05 22.6 0.0 0.00011 21.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EEA04861.1 - 0.00039 19.5 0.0 0.0048 15.9 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA04861.1 - 0.0022 17.4 0.3 0.004 16.5 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EEA04861.1 - 0.0035 17.0 0.2 0.022 14.4 0.1 1.8 1 1 1 2 2 2 1 RIO1 family FTA2 PF13095.6 EEA04861.1 - 0.071 12.7 0.1 0.53 9.9 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 UCH PF00443.29 EEA04862.1 - 1.2e-28 100.3 14.6 2.3e-28 99.4 0.0 3.9 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD PF11976.8 EEA04864.1 - 4.4e-09 36.1 0.0 3.2e-06 26.9 0.0 3.9 4 0 0 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EEA04864.1 - 0.027 14.2 0.0 0.11 12.2 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin family GCD14 PF08704.10 EEA04865.1 - 8.9e-65 218.8 0.3 3.3e-63 213.7 0.0 2.0 1 1 1 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EEA04865.1 - 1.4e-09 37.9 0.0 2e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EEA04865.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EEA04865.1 - 2e-05 24.1 0.0 4.8e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase GCD14_N PF14801.6 EEA04865.1 - 0.00072 19.3 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_25 PF13649.6 EEA04865.1 - 0.0031 18.2 0.0 0.0051 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA04865.1 - 0.0038 17.8 0.0 0.0063 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EEA04865.1 - 0.017 14.2 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 EEA04865.1 - 0.017 14.7 0.0 0.039 13.6 0.0 1.5 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_3 PF01596.17 EEA04865.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase RRM_1 PF00076.22 EEA04866.1 - 1.7e-06 27.8 0.0 3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dus PF01207.17 EEA04868.1 - 6.6e-35 120.7 0.0 1.6e-21 76.7 0.0 3.3 3 1 0 3 3 3 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EEA04868.1 - 1.5e-05 24.7 6.3 0.033 14.1 2.0 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EEA04868.1 - 0.0036 17.3 7.9 0.033 14.2 0.3 2.7 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EEA04868.1 - 0.0095 16.6 3.2 0.0095 16.6 3.2 3.1 2 1 1 3 3 3 1 Torus domain Tis11B_N PF04553.12 EEA04868.1 - 0.49 11.0 9.8 5.9 7.5 0.4 3.8 3 0 0 3 3 3 0 Tis11B like protein, N terminus zf-CCCH_4 PF18044.1 EEA04868.1 - 5.4 6.9 10.0 4.1 7.3 0.6 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger ARD PF03079.14 EEA04868.1 - 5.8 7.1 7.0 0.97 9.6 2.8 1.8 2 0 0 2 2 2 0 ARD/ARD' family zf-CCCH_2 PF14608.6 EEA04868.1 - 6.5 7.4 7.8 22 5.7 0.3 2.9 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Prefoldin PF02996.17 EEA04869.1 - 4.5e-22 78.2 0.1 6.3e-22 77.7 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Fib_alpha PF08702.10 EEA04869.1 - 0.077 13.2 1.0 0.79 9.9 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EEA04869.1 - 0.14 12.2 2.0 1.1 9.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) NicO PF03824.16 EEA04870.1 - 2 7.7 7.9 3.7 6.8 7.9 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein Beta-lactamase PF00144.24 EEA04871.1 - 4.8e-31 108.2 0.0 1e-28 100.5 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase ABC1 PF03109.16 EEA04872.1 - 6.9e-27 94.0 0.3 1.2e-26 93.2 0.3 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EEA04872.1 - 0.00061 19.4 0.1 0.19 11.3 0.0 2.4 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 EEA04872.1 - 0.0032 17.4 0.1 0.0095 15.9 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family LtuB PF17455.2 EEA04872.1 - 0.012 16.2 0.1 0.026 15.1 0.1 1.5 1 0 0 1 1 1 0 Late transcription unit B Gcd10p PF04189.13 EEA04873.1 - 1.5e-14 53.9 6.0 2.5e-10 40.0 4.8 3.2 2 1 0 2 2 2 2 Gcd10p family DUF5130 PF17174.4 EEA04873.1 - 0.016 15.4 0.0 0.04 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5130) PAF-AH_p_II PF03403.13 EEA04873.1 - 0.024 13.2 1.5 0.039 12.5 1.5 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Mem_trans PF03547.18 EEA04874.1 - 0.35 9.2 0.7 0.33 9.3 0.7 1.3 1 0 0 1 1 1 0 Membrane transport protein Ribosomal_60s PF00428.19 EEA04875.1 - 3.7e-19 69.1 0.7 4.9e-19 68.7 0.7 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Atrophin-1 PF03154.15 EEA04875.1 - 0.09 11.1 1.1 0.089 11.1 1.1 1.0 1 0 0 1 1 1 0 Atrophin-1 family Nas2_N PF18265.1 EEA04876.1 - 4.5e-29 100.2 0.1 8e-29 99.4 0.1 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 EEA04876.1 - 2.7e-06 27.1 0.0 5.8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EEA04876.1 - 0.00027 21.2 0.0 0.00069 19.9 0.0 1.7 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.24 EEA04876.1 - 0.086 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 PDZ domain DUF1048 PF06304.11 EEA04876.1 - 0.1 13.0 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) UCH PF00443.29 EEA04877.1 - 2.3e-23 83.0 1.5 3.2e-23 82.5 1.5 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EEA04877.1 - 8.1e-10 38.9 6.1 1.8e-09 37.8 6.1 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein SET PF00856.28 EEA04878.1 - 2.9 8.3 7.1 2.2 8.6 0.0 3.4 3 2 0 3 3 3 0 SET domain Actin PF00022.19 EEA04879.1 - 2.6e-123 411.6 0.0 3e-122 408.2 0.0 1.9 1 1 0 1 1 1 1 Actin Band_7 PF01145.25 EEA04880.1 - 1.2e-23 84.0 0.6 1.2e-23 84.0 0.6 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family Med2 PF11214.8 EEA04880.1 - 0.03 14.5 0.9 0.055 13.6 0.9 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 Sin3_corepress PF08295.12 EEA04881.1 - 4.3e-34 116.5 0.4 1.4e-33 114.8 0.1 2.1 2 0 0 2 2 2 1 Sin3 family co-repressor PAH PF02671.21 EEA04881.1 - 6.5e-25 87.0 3.3 1.8e-11 44.0 0.0 3.7 3 0 0 3 3 3 2 Paired amphipathic helix repeat Sin3a_C PF16879.5 EEA04881.1 - 6.2e-18 65.5 0.6 1.1e-16 61.4 0.0 3.3 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein DAD PF02109.16 EEA04882.1 - 2e-26 92.4 4.1 2.7e-26 92.0 4.1 1.1 1 0 0 1 1 1 1 DAD family Phage_holin_3_3 PF16083.5 EEA04882.1 - 5.5 7.2 8.7 11 6.2 1.5 3.0 3 1 0 3 3 3 0 LydA holin phage, holin superfamily III Pkinase PF00069.25 EEA04884.1 - 1.1e-33 116.8 2.4 1.7e-33 116.1 2.4 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA04884.1 - 1.6e-19 70.2 0.2 3.3e-19 69.2 0.2 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA04884.1 - 4.2e-05 23.0 0.0 6.4e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.20 EEA04884.1 - 0.0011 18.3 2.2 0.0042 16.5 0.2 2.1 1 1 1 2 2 2 1 Ecdysteroid kinase Kinase-like PF14531.6 EEA04884.1 - 0.0029 17.0 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EEA04884.1 - 0.0034 16.9 0.8 0.0059 16.1 0.8 1.4 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 EEA04884.1 - 0.017 15.0 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EEA04884.1 - 0.06 12.9 2.1 0.15 11.7 2.1 1.7 1 1 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EEA04884.1 - 0.07 12.7 0.5 0.23 11.0 0.1 1.9 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SpoIIIAH PF12685.7 EEA04885.1 - 0.0042 16.9 2.6 0.0051 16.7 2.6 1.0 1 0 0 1 1 1 1 SpoIIIAH-like protein Serinc PF03348.15 EEA04885.1 - 0.056 12.4 2.9 0.069 12.1 2.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.6 EEA04885.1 - 0.21 10.0 7.1 0.24 9.8 7.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Paramyxo_ncap PF00973.19 EEA04885.1 - 0.24 10.3 6.6 0.26 10.1 6.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein EIF4E-T PF10477.9 EEA04885.1 - 0.26 10.0 20.8 0.31 9.8 20.8 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Presenilin PF01080.17 EEA04885.1 - 0.26 10.0 7.1 0.32 9.7 7.1 1.2 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.13 EEA04885.1 - 0.4 9.4 2.5 0.64 8.8 2.5 1.4 1 1 0 1 1 1 0 Otopetrin CLN3 PF02487.17 EEA04885.1 - 0.47 9.4 3.6 0.5 9.4 3.6 1.2 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 EEA04885.1 - 0.77 8.9 5.5 0.83 8.8 5.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EEA04885.1 - 0.95 9.5 6.2 1.1 9.3 6.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region O-antigen_lig PF13425.6 EEA04885.1 - 1.1 8.0 8.8 1.5 7.6 8.8 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Afi1 PF07792.12 EEA04885.1 - 2.1 8.8 10.9 2.6 8.5 10.9 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking THDPS_M PF14789.6 EEA04886.1 - 0.11 12.6 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle Glycos_transf_4 PF00953.21 EEA04887.1 - 9e-38 129.8 13.8 9e-38 129.8 13.8 3.2 4 0 0 4 4 4 1 Glycosyl transferase family 4 Thioredoxin PF00085.20 EEA04888.1 - 5.2e-11 42.4 0.1 8.5e-11 41.8 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Trypan_PARP PF05887.11 EEA04888.1 - 8.3e-05 22.6 16.4 0.00014 21.9 16.4 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Thioredoxin_6 PF13848.6 EEA04888.1 - 0.00033 20.6 0.0 0.00077 19.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain RNA_pol_Rpc4 PF05132.14 EEA04888.1 - 0.0022 18.4 2.3 0.0033 17.8 2.3 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 V_ATPase_I PF01496.19 EEA04888.1 - 0.0047 14.9 3.4 0.0065 14.5 3.4 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Nop14 PF04147.12 EEA04888.1 - 0.0074 14.6 38.9 0.0097 14.2 38.9 1.1 1 0 0 1 1 1 1 Nop14-like family SAPS PF04499.15 EEA04888.1 - 0.0093 14.8 12.0 0.012 14.5 12.0 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein PA26 PF04636.13 EEA04888.1 - 0.012 14.6 1.2 0.017 14.1 1.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Zip PF02535.22 EEA04888.1 - 0.013 14.7 4.6 0.019 14.2 4.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Spore_coat_CotO PF14153.6 EEA04888.1 - 0.015 15.3 10.4 0.022 14.7 10.4 1.2 1 0 0 1 1 1 0 Spore coat protein CotO CDC45 PF02724.14 EEA04888.1 - 0.016 13.5 31.9 0.023 13.0 31.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 EEA04888.1 - 0.019 13.4 0.3 0.029 12.8 0.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OST3_OST6 PF04756.13 EEA04888.1 - 0.031 13.6 1.9 0.045 13.1 0.5 1.9 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Serinc PF03348.15 EEA04888.1 - 0.057 12.3 0.5 0.094 11.6 0.5 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF5622 PF18533.1 EEA04888.1 - 0.065 13.4 0.5 0.16 12.2 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5622) DNA_pol_phi PF04931.13 EEA04888.1 - 0.068 11.3 46.2 0.13 10.3 46.2 1.5 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EEA04888.1 - 0.12 11.7 40.7 0.17 11.3 40.7 1.1 1 0 0 1 1 1 0 SDA1 CSRNP_N PF16019.5 EEA04888.1 - 0.22 11.4 7.8 0.45 10.4 7.8 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Mpp10 PF04006.12 EEA04888.1 - 0.33 9.3 38.1 0.45 8.9 38.1 1.1 1 0 0 1 1 1 0 Mpp10 protein SLC12 PF03522.15 EEA04888.1 - 0.39 9.7 4.7 0.51 9.3 4.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 EEA04888.1 - 1.9 8.3 17.2 3 7.6 17.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Smg8_Smg9 PF10220.9 EEA04888.1 - 3 6.0 7.7 3.9 5.7 7.7 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Vfa1 PF08432.10 EEA04888.1 - 4.7 7.5 20.5 9.3 6.5 20.5 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 EEA04888.1 - 5.3 5.7 13.3 7.5 5.2 13.3 1.2 1 0 0 1 1 1 0 Presenilin DUF2151 PF10221.9 EEA04888.1 - 5.5 5.4 15.1 8.1 4.9 15.1 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator BUD22 PF09073.10 EEA04888.1 - 5.8 6.1 38.1 8.3 5.6 38.1 1.1 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 EEA04888.1 - 6.4 5.4 15.0 10 4.8 15.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAR2 PF05282.11 EEA04888.1 - 7.2 5.9 9.2 12 5.2 9.2 1.3 1 0 0 1 1 1 0 AAR2 protein LSM PF01423.22 EEA04889.1 - 1.2e-15 56.9 2.9 1.6e-15 56.6 2.9 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA04889.1 - 0.015 15.4 0.2 0.02 15.0 0.2 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain RBP_receptor PF14752.6 EEA04889.1 - 0.085 11.4 0.1 0.096 11.2 0.1 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor Gemin7 PF11095.8 EEA04889.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) Ribosomal_S13_N PF08069.12 EEA04890.1 - 9.2e-28 96.1 0.4 1.7e-27 95.2 0.4 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EEA04890.1 - 7.3e-14 51.8 1.1 9.7e-14 51.3 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 IMS_C PF11799.8 EEA04890.1 - 0.11 13.2 0.2 0.19 12.4 0.2 1.6 1 1 0 1 1 1 0 impB/mucB/samB family C-terminal domain RRM_1 PF00076.22 EEA04891.1 - 8.8e-32 108.8 0.2 3e-14 52.6 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EEA04891.1 - 0.0013 19.0 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 EEA04891.1 - 0.0035 17.4 0.2 6.8 6.9 0.1 3.2 2 2 0 2 2 2 2 RNA recognition motif Endonuclease_NS PF01223.23 EEA04892.1 - 8.5e-37 127.1 0.1 1.9e-33 116.2 0.2 2.2 2 0 0 2 2 2 2 DNA/RNA non-specific endonuclease HALZ PF02183.18 EEA04893.1 - 0.016 15.4 3.8 0.032 14.5 3.8 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Helo_like_N PF17111.5 EEA04893.1 - 0.02 14.2 1.5 0.067 12.6 1.5 1.8 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins YabA PF06156.13 EEA04893.1 - 0.093 13.4 2.2 0.51 11.0 2.2 2.3 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 EEA04893.1 - 0.34 11.4 5.2 1.3 9.5 5.2 2.0 1 0 0 1 1 1 0 Cell division protein ZapB ADIP PF11559.8 EEA04893.1 - 2.6 8.1 11.9 0.17 12.0 5.9 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1837 PF08878.11 EEA04895.1 - 0.023 14.5 0.1 0.046 13.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1837) T3RM_EcoP15I_C PF18273.1 EEA04895.1 - 0.073 13.4 0.1 0.13 12.6 0.1 1.5 1 1 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain EF-hand_8 PF13833.6 EEA04896.1 - 0.012 15.4 0.2 0.48 10.3 0.0 2.8 2 1 0 2 2 2 0 EF-hand domain pair Zip PF02535.22 EEA04897.1 - 4.4e-36 124.8 12.8 5.7e-36 124.4 12.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Gin PF10764.9 EEA04897.1 - 0.12 12.3 0.4 0.78 9.7 0.4 2.4 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin MTHFR_C PF12225.8 EEA04898.1 - 0.61 9.8 7.6 1.9 8.2 7.6 1.8 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal Chromo PF00385.24 EEA04899.1 - 3.2e-11 43.0 0.7 7.2e-11 41.8 0.7 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RWD PF05773.22 EEA04900.1 - 7.6e-15 55.2 1.4 1.4e-14 54.3 1.4 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EEA04900.1 - 0.0071 16.8 0.1 0.012 16.0 0.1 1.4 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 UQ_con PF00179.26 EEA04900.1 - 0.01 15.5 0.1 0.015 14.9 0.1 1.4 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme Elf1 PF05129.13 EEA04901.1 - 1.6e-28 98.6 2.1 2.5e-28 98.0 2.1 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 EEA04901.1 - 0.0063 16.9 0.1 0.016 15.6 0.1 1.6 1 0 0 1 1 1 1 Restriction alleviation protein Lar DUF4931 PF16285.5 EEA04901.1 - 0.059 12.7 2.3 0.89 8.8 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4931) zf-Di19 PF05605.12 EEA04901.1 - 9.2 6.7 7.0 2.2 8.6 2.6 2.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DNA_methylase PF00145.17 EEA04902.1 - 3.5e-26 92.3 0.1 5.4e-26 91.7 0.1 1.2 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase FCH PF00611.23 EEA04903.1 - 2.6e-09 37.2 8.2 4.6e-09 36.4 0.1 3.8 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain EcKinase PF02958.20 EEA04903.1 - 0.00051 19.4 1.1 0.00051 19.4 1.1 2.0 2 0 0 2 2 2 1 Ecdysteroid kinase Nipped-B_C PF12830.7 EEA04904.1 - 1.3e-09 38.3 2.2 1.7e-09 37.9 0.1 2.3 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus HEAT PF02985.22 EEA04904.1 - 8.9e-08 31.8 0.4 0.11 12.8 0.1 4.5 4 0 0 4 4 4 2 HEAT repeat PHD PF00628.29 EEA04904.1 - 3.3e-06 26.9 8.7 3.3e-06 26.9 8.7 2.6 2 0 0 2 2 2 1 PHD-finger Cnd1 PF12717.7 EEA04904.1 - 0.01 15.9 13.3 0.39 10.8 0.1 5.6 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA04904.1 - 0.012 16.0 0.1 1.2 9.6 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats PHD_2 PF13831.6 EEA04904.1 - 0.031 13.8 8.3 0.01 15.4 4.3 2.3 2 0 0 2 2 2 0 PHD-finger HEAT_EZ PF13513.6 EEA04904.1 - 0.21 12.1 1.0 8.1 7.1 0.3 3.3 2 1 1 3 3 3 0 HEAT-like repeat SNF2_N PF00176.23 EEA04905.1 - 1.5e-76 257.4 1.3 2.5e-76 256.7 1.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA04905.1 - 1.6e-14 54.1 0.3 9.6e-14 51.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 EEA04905.1 - 3.8e-08 33.0 6.8 8.8e-08 31.9 6.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA04905.1 - 1.4e-07 31.5 9.8 2.9e-07 30.5 9.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EEA04905.1 - 4.9e-07 29.7 5.5 1.1e-06 28.6 5.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EEA04905.1 - 5.4e-06 26.6 7.6 1.2e-05 25.6 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EEA04905.1 - 5.5e-06 26.2 8.2 1.2e-05 25.1 8.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA04905.1 - 6.6e-06 25.9 8.1 1.3e-05 25.0 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA04905.1 - 9.5e-05 22.2 6.0 0.00024 20.9 6.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DEAD PF00270.29 EEA04905.1 - 0.00046 20.0 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 EEA04905.1 - 0.0011 18.9 6.2 0.0022 17.9 6.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain UBA_4 PF14555.6 EEA04905.1 - 0.076 12.8 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain zf-RING_4 PF14570.6 EEA04905.1 - 0.37 10.6 5.6 0.81 9.5 5.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EEA04905.1 - 1.6 8.9 9.8 1.3 9.2 7.0 2.2 1 1 1 2 2 2 0 zinc RING finger of MSL2 DEAD PF00270.29 EEA04906.1 - 9.8e-19 67.8 0.0 3.1e-18 66.2 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA04906.1 - 9.3e-13 48.5 0.1 7.8e-12 45.5 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA04906.1 - 0.00043 20.6 0.1 0.0026 18.1 0.1 2.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF935 PF06074.12 EEA04906.1 - 0.099 11.4 0.3 0.17 10.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF935) Adaptin_binding PF10199.9 EEA04906.1 - 0.62 10.7 8.7 3.4 8.3 0.6 2.7 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 FHA PF00498.26 EEA04908.1 - 1.1e-17 64.1 0.3 1.1e-17 64.1 0.3 3.3 4 0 0 4 4 4 1 FHA domain Yop-YscD_cpl PF16697.5 EEA04908.1 - 1.5e-09 38.0 0.1 1e-08 35.4 0.0 2.4 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Cob_adeno_trans PF01923.18 EEA04908.1 - 0.11 12.6 8.0 0.16 12.1 3.0 3.0 3 1 0 3 3 3 0 Cobalamin adenosyltransferase DUF4214 PF13946.6 EEA04908.1 - 0.14 12.2 2.0 0.6 10.2 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4214) T3SSipB PF16535.5 EEA04908.1 - 1.5 9.3 6.2 0.52 10.8 0.8 2.5 1 1 1 2 2 2 0 Type III cell invasion protein SipB DUF1664 PF07889.12 EEA04908.1 - 1.8 8.6 13.9 5.2 7.1 1.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PspB PF06667.12 EEA04908.1 - 2.8 8.1 4.1 2.4 8.3 0.3 2.5 2 0 0 2 2 2 0 Phage shock protein B Speriolin_C PF15059.6 EEA04908.1 - 4.2 7.5 14.5 8 6.6 0.6 2.6 1 1 1 2 2 2 0 Speriolin C-terminus ERM PF00769.19 EEA04908.1 - 5.2 6.8 27.1 0.084 12.7 18.9 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Glycos_transf_2 PF00535.26 EEA04909.1 - 3.9e-32 111.4 0.0 4.7e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EEA04909.1 - 8e-12 45.5 0.0 1e-11 45.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EEA04909.1 - 6e-06 25.9 0.0 8e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EEA04909.1 - 0.014 14.9 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 PITH PF06201.13 EEA04910.1 - 1.2e-22 80.8 2.6 1.7e-22 80.3 2.6 1.2 1 0 0 1 1 1 1 PITH domain CAP PF00188.26 EEA04911.1 - 2.9e-20 73.4 2.2 2.9e-20 73.4 2.2 2.1 2 0 0 2 2 2 1 Cysteine-rich secretory protein family AAA PF00004.29 EEA04912.1 - 4.8e-84 279.4 0.0 2.4e-48 163.9 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA04912.1 - 3.7e-21 74.6 0.1 1.5e-10 40.7 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EEA04912.1 - 9.9e-13 48.1 0.0 5e-05 23.1 0.0 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA04912.1 - 2.4e-11 44.3 0.3 2.3e-05 24.8 0.0 4.2 3 2 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA04912.1 - 2.1e-09 37.7 0.2 0.0044 17.3 0.0 5.0 3 2 2 5 5 4 1 AAA domain AAA_2 PF07724.14 EEA04912.1 - 5e-09 36.5 0.0 4.5e-05 23.6 0.0 3.4 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EEA04912.1 - 7.9e-09 35.2 0.2 0.002 17.4 0.0 2.9 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_33 PF13671.6 EEA04912.1 - 1.3e-08 35.1 0.0 0.0064 16.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EEA04912.1 - 7.8e-08 32.4 0.0 0.0055 16.7 0.0 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EEA04912.1 - 1.4e-07 31.4 0.2 0.013 15.2 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_18 PF13238.6 EEA04912.1 - 2.4e-06 28.1 0.2 0.011 16.3 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 EEA04912.1 - 1e-05 25.2 1.1 0.86 9.1 0.1 3.8 2 2 0 3 3 3 2 AAA domain TsaE PF02367.17 EEA04912.1 - 1.2e-05 25.4 0.0 0.06 13.4 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EEA04912.1 - 2.6e-05 24.7 0.4 0.0076 16.8 0.0 3.3 3 0 0 3 3 3 1 ABC transporter Mg_chelatase PF01078.21 EEA04912.1 - 3.4e-05 23.3 0.9 0.025 14.0 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA04912.1 - 3.6e-05 24.1 0.0 0.012 16.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Zeta_toxin PF06414.12 EEA04912.1 - 7.3e-05 22.1 0.0 0.029 13.6 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_14 PF13173.6 EEA04912.1 - 7.9e-05 22.7 0.0 0.006 16.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EEA04912.1 - 0.00011 22.0 2.2 0.087 12.6 0.0 3.1 4 0 0 4 4 4 2 AAA domain NACHT PF05729.12 EEA04912.1 - 0.00014 21.8 0.1 0.14 12.0 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_3 PF07726.11 EEA04912.1 - 0.00016 21.5 0.0 0.67 9.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA04912.1 - 0.00038 20.3 0.1 0.19 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EEA04912.1 - 0.00066 20.0 0.1 0.096 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EEA04912.1 - 0.0011 18.7 0.0 0.15 11.7 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain PhoH PF02562.16 EEA04912.1 - 0.0019 17.7 0.1 2.8 7.4 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ATPase PF06745.13 EEA04912.1 - 0.002 17.5 0.3 0.7 9.2 0.0 3.5 4 0 0 4 4 4 1 KaiC Rad17 PF03215.15 EEA04912.1 - 0.0025 17.8 0.0 0.037 13.9 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 EEA04912.1 - 0.0035 17.1 0.0 0.076 12.7 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 EEA04912.1 - 0.0037 17.7 3.0 0.27 11.6 0.0 3.6 5 0 0 5 5 2 1 AAA domain ATPase_2 PF01637.18 EEA04912.1 - 0.0057 16.6 0.0 0.12 12.2 0.0 2.7 2 1 1 3 3 2 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EEA04912.1 - 0.0075 15.5 0.1 0.25 10.5 0.0 3.2 4 0 0 4 4 4 1 NB-ARC domain AAA_7 PF12775.7 EEA04912.1 - 0.0088 15.6 0.0 1.2 8.6 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 EEA04912.1 - 0.015 15.7 1.0 10 6.5 0.3 3.0 3 0 0 3 3 2 0 AAA domain Parvo_NS1 PF01057.17 EEA04912.1 - 0.022 13.8 0.0 0.24 10.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 DUF815 PF05673.13 EEA04912.1 - 0.033 13.3 0.0 0.22 10.7 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 EEA04912.1 - 0.07 12.8 0.1 11 5.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EEA04912.1 - 0.093 12.0 0.1 14 4.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EEA04912.1 - 0.11 12.4 0.0 14 5.6 0.0 3.0 3 0 0 3 3 2 0 NTPase Cytidylate_kin PF02224.18 EEA04912.1 - 0.12 12.0 0.1 11 5.7 0.0 2.8 3 0 0 3 3 2 0 Cytidylate kinase CPT PF07931.12 EEA04912.1 - 0.14 12.0 0.0 21 4.9 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ATP-synt_ab PF00006.25 EEA04912.1 - 0.15 11.7 0.0 0.41 10.3 0.0 1.7 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RIO1 PF01163.22 EEA04913.1 - 4e-52 176.5 0.5 5.9e-28 97.7 0.1 3.0 3 1 1 4 4 4 2 RIO1 family Peptidase_M60 PF13402.6 EEA04914.1 - 2.6e-47 161.6 0.7 7.4e-47 160.1 0.0 2.0 2 0 0 2 2 2 1 Peptidase M60, enhancin and enhancin-like M60-like_N PF17291.2 EEA04914.1 - 1.2e-06 28.3 0.0 3.9e-06 26.7 0.0 1.8 1 1 0 1 1 1 1 N-terminal domain of M60-like peptidases S-AdoMet_synt_N PF00438.20 EEA04914.1 - 0.11 13.2 0.2 0.99 10.1 0.0 2.6 3 0 0 3 3 3 0 S-adenosylmethionine synthetase, N-terminal domain KLRAQ PF10205.9 EEA04915.1 - 0.66 10.2 7.2 0.34 11.2 1.2 3.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein PH PF00169.29 EEA04916.1 - 8.2e-19 68.1 0.3 1e-18 67.8 0.3 1.1 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EEA04916.1 - 1.9e-05 24.7 0.1 4.9e-05 23.4 0.1 1.6 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 EEA04916.1 - 0.00013 22.2 0.1 0.00019 21.6 0.1 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EEA04916.1 - 0.00021 21.6 1.5 0.0049 17.3 1.5 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 EEA04916.1 - 0.0077 16.0 0.0 0.013 15.3 0.0 1.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EEA04916.1 - 0.098 13.0 0.0 0.17 12.3 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain Enolase_C PF00113.22 EEA04917.1 - 1.3e-138 461.3 0.0 1.6e-138 461.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EEA04917.1 - 4.9e-55 185.3 0.0 7.4e-55 184.7 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EEA04917.1 - 6.1e-10 39.0 0.0 1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EEA04917.1 - 0.011 14.8 0.1 0.02 14.0 0.1 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus MR_MLE_N PF02746.16 EEA04917.1 - 0.029 14.6 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain CPBP PF02517.16 EEA04918.1 - 3.5e-14 52.9 6.2 3.5e-14 52.9 6.2 2.4 2 2 0 2 2 2 1 CPBP intramembrane metalloprotease DUF572 PF04502.13 EEA04919.1 - 0.58 9.7 13.5 0.19 11.3 5.9 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF572) RNA_POL_M_15KD PF02150.16 EEA04919.1 - 0.95 9.4 6.4 2.2 8.2 0.1 3.2 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit Tnp_zf-ribbon_2 PF13842.6 EEA04919.1 - 6.1 7.7 10.2 12 6.8 0.2 3.5 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon Ste5 PF11610.8 EEA04920.1 - 0.052 13.4 7.3 0.91 9.5 0.7 4.6 4 0 0 4 4 4 0 Scaffold protein Ste5, Fus3-binding region PH PF00169.29 EEA04921.1 - 0.0019 18.7 0.1 0.0059 17.1 0.1 1.9 1 0 0 1 1 1 1 PH domain EF-hand_7 PF13499.6 EEA04922.1 - 1.6e-06 28.5 2.6 1.6e-06 28.5 2.6 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EEA04922.1 - 2.1e-06 26.9 0.5 2.1e-06 26.9 0.5 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EEA04922.1 - 4.6e-06 26.1 1.4 1.2e-05 24.9 0.6 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EEA04922.1 - 1.4e-05 24.9 3.2 4.4e-05 23.2 0.2 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 EEA04922.1 - 0.0011 18.4 1.0 0.0047 16.4 0.5 2.3 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 EEA04922.1 - 0.0058 17.5 0.0 0.013 16.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain Plasmod_dom_1 PF09715.10 EEA04922.1 - 0.0073 16.3 0.8 0.021 14.9 0.8 1.8 1 0 0 1 1 1 1 Plasmodium protein of unknown function (Plasmod_dom_1) ATP_bind_1 PF03029.17 EEA04923.1 - 1e-65 221.9 0.1 1.3e-65 221.6 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EEA04923.1 - 0.0013 18.7 0.1 0.23 11.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EEA04923.1 - 0.0062 16.1 0.1 1 8.9 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CLP1_P PF16575.5 EEA04923.1 - 0.019 14.8 0.1 0.086 12.6 0.1 2.1 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NAP PF00956.18 EEA04923.1 - 0.022 13.9 1.4 0.035 13.3 1.4 1.2 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) SRP54 PF00448.22 EEA04923.1 - 0.031 13.9 0.1 2.3 7.8 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF463 PF04317.12 EEA04923.1 - 0.046 12.6 0.3 4.3 6.1 0.0 2.2 2 0 0 2 2 2 0 YcjX-like family, DUF463 DUF87 PF01935.17 EEA04923.1 - 0.074 13.1 0.2 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain CbiA PF01656.23 EEA04923.1 - 0.081 13.0 0.0 0.097 12.7 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain FlaC_arch PF05377.11 EEA04925.1 - 0.0029 18.0 7.2 0.31 11.5 0.3 3.5 3 0 0 3 3 3 1 Flagella accessory protein C (FlaC) PRANC PF09372.10 EEA04925.1 - 0.0049 17.2 9.1 0.15 12.4 0.8 2.5 2 0 0 2 2 2 2 PRANC domain CCDC-167 PF15188.6 EEA04925.1 - 0.014 15.7 0.9 0.19 12.1 0.9 2.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF4618 PF15397.6 EEA04925.1 - 0.024 14.0 4.3 0.055 12.9 4.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) TRAF_BIRC3_bd PF16673.5 EEA04925.1 - 0.067 13.0 7.9 0.57 10.0 0.6 3.3 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Not3 PF04065.15 EEA04925.1 - 0.078 12.4 7.3 0.43 10.0 0.8 2.1 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Vac_Fusion PF02346.16 EEA04925.1 - 0.12 12.0 3.6 0.22 11.1 0.0 3.0 4 1 1 5 5 4 0 Chordopoxvirus multifunctional envelope protein A27 CENP-F_leu_zip PF10473.9 EEA04925.1 - 0.12 12.4 5.5 2.7 8.0 1.2 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LXG PF04740.12 EEA04925.1 - 0.19 11.4 5.6 3.6 7.2 5.5 2.3 1 1 0 1 1 1 0 LXG domain of WXG superfamily THOC7 PF05615.13 EEA04925.1 - 0.24 11.7 3.5 5.1 7.4 0.5 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4363 PF14276.6 EEA04925.1 - 0.29 11.3 5.6 0.92 9.7 0.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) DUF16 PF01519.16 EEA04925.1 - 0.4 11.2 9.2 5 7.7 2.3 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 TSNAXIP1_N PF15739.5 EEA04925.1 - 0.84 10.0 5.7 1.4 9.3 0.4 2.7 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus Fzo_mitofusin PF04799.13 EEA04925.1 - 1.2 8.7 3.8 1.1 8.8 0.4 2.4 2 1 1 3 3 3 0 fzo-like conserved region SlyX PF04102.12 EEA04925.1 - 1.2 9.8 4.3 30 5.3 1.7 2.9 3 0 0 3 3 2 0 SlyX Nucleoporin_FG PF13634.6 EEA04925.1 - 1.5 9.7 44.1 0.49 11.3 4.9 2.8 2 1 0 2 2 2 0 Nucleoporin FG repeat region DUF1664 PF07889.12 EEA04925.1 - 1.6 8.8 4.5 14 5.8 0.3 2.9 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 EEA04925.1 - 2.6 8.4 5.5 15 6.0 1.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Prefoldin_2 PF01920.20 EEA04925.1 - 3.8 7.5 7.4 5.9 6.9 0.3 3.1 3 1 1 4 4 4 0 Prefoldin subunit Cpn60_TCP1 PF00118.24 EEA04926.1 - 2.4e-140 468.4 16.3 2.9e-140 468.2 16.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family LETM1 PF07766.13 EEA04927.1 - 7.4e-77 258.3 4.2 9.2e-77 258.0 4.2 1.0 1 0 0 1 1 1 1 LETM1-like protein Cactin_mid PF10312.9 EEA04927.1 - 0.029 14.1 0.9 0.046 13.4 0.9 1.3 1 0 0 1 1 1 0 Conserved mid region of cactin COMPASS-Shg1 PF05205.12 EEA04927.1 - 0.14 12.9 2.9 0.26 12.0 2.9 1.4 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Las1 PF04031.13 EEA04928.1 - 7.5e-40 136.5 0.1 1.6e-39 135.5 0.1 1.6 1 0 0 1 1 1 1 Las1-like EntA_Immun PF08951.10 EEA04928.1 - 1.2 9.5 5.1 1.5 9.2 0.0 3.9 4 1 1 5 5 5 0 Enterocin A Immunity Gpi1 PF05024.15 EEA04929.1 - 1.6e-44 152.3 22.1 4.9e-44 150.7 22.1 1.9 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) NUC153 PF08159.12 EEA04930.1 - 2e-12 46.7 8.1 1.4e-08 34.4 0.1 3.7 3 0 0 3 3 3 3 NUC153 domain zf-CCCH_2 PF14608.6 EEA04931.1 - 0.018 15.5 5.5 0.018 15.5 5.5 3.4 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger tRNA-Thr_ED PF08915.11 EEA04931.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase Proteasome PF00227.26 EEA04932.1 - 2.1e-55 187.2 0.8 2.9e-55 186.7 0.8 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA04932.1 - 8e-14 51.0 0.0 1.5e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5089 PF17002.5 EEA04933.1 - 7.8e-06 25.9 18.0 3.9e-05 23.6 17.4 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) Sec20 PF03908.13 EEA04933.1 - 0.0075 16.2 9.0 0.17 11.9 2.1 2.7 2 1 0 2 2 2 2 Sec20 NPV_P10 PF05531.12 EEA04933.1 - 0.013 15.9 12.9 0.045 14.2 2.9 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 EEA04933.1 - 0.014 15.4 9.8 0.14 12.2 1.7 2.4 2 0 0 2 2 2 0 Laminin Domain II V-SNARE_C PF12352.8 EEA04933.1 - 0.016 15.5 5.6 0.28 11.5 0.4 3.2 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus COG2 PF06148.11 EEA04933.1 - 0.019 15.1 1.1 0.019 15.1 1.1 2.4 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 BLOC1_2 PF10046.9 EEA04933.1 - 0.031 14.6 14.4 0.75 10.1 0.8 2.8 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TBCA PF02970.16 EEA04933.1 - 0.039 14.3 3.0 0.039 14.3 3.0 2.5 3 0 0 3 3 2 0 Tubulin binding cofactor A DUF1664 PF07889.12 EEA04933.1 - 0.13 12.3 10.0 2 8.5 1.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 EEA04933.1 - 0.15 12.6 8.2 0.43 11.2 1.9 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CHDCT2 PF08074.11 EEA04933.1 - 0.2 11.8 5.7 5.3 7.2 0.1 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain DUF16 PF01519.16 EEA04933.1 - 0.42 11.1 16.4 0.14 12.7 2.7 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 Dynamitin PF04912.14 EEA04933.1 - 0.68 9.2 14.2 0.21 10.9 3.1 2.2 2 0 0 2 2 2 0 Dynamitin HIP1_clath_bdg PF16515.5 EEA04933.1 - 0.96 10.1 13.2 0.058 14.0 3.4 2.7 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CdvA PF18822.1 EEA04933.1 - 2.2 8.2 15.4 2.8 7.8 2.1 3.4 2 2 1 3 3 3 0 CdvA-like coiled-coil domain KxDL PF10241.9 EEA04933.1 - 2.3 8.6 18.8 0.85 9.9 0.8 3.9 2 2 2 4 4 4 0 Uncharacterized conserved protein Use1 PF09753.9 EEA04933.1 - 8.5 6.0 18.2 0.5 10.0 6.7 2.6 2 2 0 2 2 2 0 Membrane fusion protein Use1 KCNQC3-Ank-G_bd PF11956.8 EEA04934.1 - 2.4 8.5 4.2 8.2 6.8 0.0 2.7 2 1 0 3 3 3 0 Ankyrin-G binding motif of KCNQ2-3 Isy1 PF06246.12 EEA04935.1 - 4e-47 161.0 3.4 5.1e-47 160.6 3.4 1.1 1 0 0 1 1 1 1 Isy1-like splicing family NFACT-R_1 PF05670.13 EEA04936.1 - 2.7e-32 111.7 0.0 1.9e-31 109.0 0.0 2.6 2 0 0 2 2 2 1 NFACT protein RNA binding domain FbpA PF05833.11 EEA04936.1 - 7.3e-22 77.8 10.8 1.4e-15 57.0 0.2 2.7 2 0 0 2 2 2 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 EEA04936.1 - 1.5e-15 57.0 0.1 7.3e-15 54.8 0.1 2.3 2 0 0 2 2 2 1 NFACT protein C-terminal domain Mt_ATP-synt_D PF05873.12 EEA04936.1 - 1.9 8.3 8.1 0.25 11.2 2.5 2.4 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Ras PF00071.22 EEA04937.1 - 8.6e-14 51.5 0.1 2.2e-11 43.7 0.1 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EEA04937.1 - 0.00033 20.8 0.0 0.38 11.0 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA04937.1 - 0.0017 17.8 0.0 0.19 11.2 0.1 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA04937.1 - 0.0095 15.5 0.1 3.2 7.3 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA04937.1 - 0.02 14.9 0.0 0.078 13.1 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 EEA04937.1 - 0.045 13.4 1.0 0.079 12.6 1.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EEA04937.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 EEA04937.1 - 0.14 12.2 1.2 2.6 8.1 0.0 2.8 4 0 0 4 4 4 0 Dynamin family Gar1 PF04410.14 EEA04938.1 - 1.4e-35 122.4 0.4 2.4e-35 121.6 0.2 1.4 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region HORMA PF02301.18 EEA04939.1 - 4.1e-58 196.5 0.0 7e-58 195.7 0.0 1.4 1 0 0 1 1 1 1 HORMA domain Ribosomal_S25 PF03297.15 EEA04939.1 - 0.22 11.7 0.0 0.22 11.7 0.0 2.3 3 0 0 3 3 3 0 S25 ribosomal protein PRP3 PF08572.10 EEA04940.1 - 5.8e-55 186.5 4.6 5.8e-55 186.5 4.6 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EEA04940.1 - 1.3e-28 99.9 1.6 1.3e-28 99.9 1.6 3.5 4 1 0 4 4 4 1 Protein of unknown function (DUF1115) Ribosomal_S16 PF00886.19 EEA04940.1 - 0.11 12.6 0.0 0.4 10.8 0.0 2.0 1 1 1 2 2 2 0 Ribosomal protein S16 Methyltr_RsmB-F PF01189.17 EEA04941.1 - 4e-25 88.6 0.4 1.2e-24 87.1 0.4 1.8 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F ComFB PF10719.9 EEA04941.1 - 0.025 14.7 0.1 0.079 13.1 0.1 1.9 1 0 0 1 1 1 0 Late competence development protein ComFB bPH_3 PF14470.6 EEA04941.1 - 0.084 13.3 0.3 0.084 13.3 0.3 2.5 2 0 0 2 2 2 0 Bacterial PH domain CTP_synth_N PF06418.14 EEA04943.1 - 1.3e-111 372.1 0.1 2.3e-111 371.4 0.1 1.4 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EEA04943.1 - 5.6e-47 160.0 0.0 1.8e-46 158.3 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EEA04943.1 - 8e-05 22.5 0.8 0.18 11.5 0.2 3.3 2 1 1 3 3 3 2 Peptidase C26 CbiA PF01656.23 EEA04943.1 - 0.0095 16.0 0.0 0.016 15.3 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EEA04943.1 - 0.064 12.2 0.1 0.11 11.4 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SNARE_assoc PF09335.11 EEA04944.1 - 0.019 15.5 0.9 0.019 15.5 0.9 1.9 2 0 0 2 2 2 0 SNARE associated Golgi protein SUR7 PF06687.12 EEA04944.1 - 0.069 12.8 16.8 0.015 14.9 5.7 2.1 1 1 1 2 2 2 0 SUR7/PalI family DUF2777 PF10949.8 EEA04944.1 - 0.076 12.7 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) E1-E2_ATPase PF00122.20 EEA04944.1 - 0.084 12.4 7.3 0.25 10.8 4.2 2.3 1 1 1 2 2 2 0 E1-E2 ATPase Cytochrom_B561 PF03188.16 EEA04945.1 - 0.019 15.1 0.5 0.036 14.2 0.5 1.4 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 CactinC_cactus PF09732.9 EEA04946.1 - 2.8e-37 127.4 6.6 1.1e-36 125.5 6.6 2.1 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 EEA04946.1 - 1.6e-08 34.5 7.5 4.2e-08 33.1 7.5 1.7 1 0 0 1 1 1 1 Conserved mid region of cactin FlgH PF02107.16 EEA04947.1 - 0.028 14.0 0.1 0.028 14.0 0.1 2.9 3 1 0 3 3 3 0 Flagellar L-ring protein DJ-1_PfpI PF01965.24 EEA04950.1 - 6.5e-35 120.4 0.1 7.5e-35 120.2 0.1 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EEA04950.1 - 0.14 11.7 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain MORN PF02493.20 EEA04951.1 - 7.3e-63 204.9 69.0 1.2e-08 34.3 1.5 12.6 13 0 0 13 13 13 12 MORN repeat Aa_trans PF01490.18 EEA04952.1 - 4e-37 127.9 31.9 8.3e-37 126.9 31.9 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein TMEM100 PF16311.5 EEA04952.1 - 0.26 10.9 4.4 2 8.0 3.5 2.5 2 0 0 2 2 2 0 Transmembrane protein 100 Aa_trans PF01490.18 EEA04953.1 - 1.4e-27 96.5 25.2 2e-27 95.9 25.2 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein zf-CW PF07496.15 EEA04954.1 - 2e-16 59.7 5.1 6.5e-16 58.1 5.1 2.0 1 0 0 1 1 1 1 CW-type Zinc Finger IF-2B PF01008.17 EEA04956.1 - 1.1e-37 129.9 0.0 1.3e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family L27_N PF09060.10 EEA04956.1 - 0.11 12.6 0.2 0.42 10.7 0.1 2.0 2 0 0 2 2 2 0 L27_N Choline_transpo PF04515.12 EEA04958.1 - 0.2 10.8 7.2 0.081 12.1 0.9 2.5 3 0 0 3 3 3 0 Plasma-membrane choline transporter Ribosomal_L3 PF00297.22 EEA04959.1 - 5.2e-168 558.8 2.5 5.9e-168 558.6 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Yip1 PF04893.17 EEA04960.1 - 1.3e-06 28.3 17.9 1.9e-06 27.7 17.9 1.3 1 1 0 1 1 1 1 Yip1 domain Robl_LC7 PF03259.17 EEA04962.1 - 2.1e-09 37.0 0.0 2.8e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 EEA04962.1 - 0.0022 17.9 0.0 0.0031 17.4 0.0 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 GAPES3 PF17154.4 EEA04962.1 - 0.14 12.1 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain Myb_DNA-bind_3 PF12776.7 EEA04963.1 - 1.5 9.8 10.0 0.24 12.4 5.6 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain zinc_ribbon_10 PF10058.9 EEA04965.1 - 0.63 9.8 3.9 0.52 10.1 2.0 1.8 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DED PF01335.21 EEA04966.1 - 0.018 15.3 0.8 1.1 9.6 0.1 2.9 2 0 0 2 2 2 0 Death effector domain SFTA2 PF15210.6 EEA04966.1 - 0.065 13.2 0.4 0.21 11.5 0.4 1.9 1 0 0 1 1 1 0 Surfactant-associated protein 2 YfhO PF09586.10 EEA04967.1 - 9.3 4.3 10.0 22 3.1 10.0 1.6 1 0 0 1 1 1 0 Bacterial membrane protein YfhO MRP-S33 PF08293.11 EEA04968.1 - 0.069 13.4 0.8 0.26 11.5 0.1 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal subunit S27 TrmB PF01978.19 EEA04968.1 - 0.16 11.9 17.0 8.1 6.4 0.0 7.9 2 2 9 11 11 11 0 Sugar-specific transcriptional regulator TrmB Spore_YunB PF09560.10 EEA04968.1 - 0.17 11.9 9.1 54 3.9 0.1 6.2 3 2 5 9 9 9 0 Sporulation protein YunB (Spo_YunB) CHIP_TPR_N PF18391.1 EEA04968.1 - 4.5 8.1 10.5 0.99 10.2 2.7 3.4 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain DUF2841 PF11001.8 EEA04970.1 - 0.21 11.6 2.3 1.6 8.8 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2841) PRANC PF09372.10 EEA04971.1 - 0.41 11.0 3.6 0.34 11.2 0.7 2.5 2 0 0 2 2 2 0 PRANC domain NDK PF00334.19 EEA04972.1 - 1.7e-45 154.4 0.0 2.5e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Pentapeptide_4 PF13599.6 EEA04972.1 - 0.03 14.5 2.0 0.062 13.5 2.0 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) SmpB PF01668.18 EEA04972.1 - 0.085 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 SmpB protein DUF2729 PF10870.8 EEA04975.1 - 0.094 12.6 0.2 0.28 11.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2729) DUF948 PF06103.11 EEA04975.1 - 4.5 7.6 6.0 2 8.7 1.4 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Aldo_ket_red PF00248.21 EEA04976.1 - 0.037 13.2 0.1 0.29 10.3 0.0 2.3 2 0 0 2 2 2 0 Aldo/keto reductase family Asp PF00026.23 EEA04977.1 - 6.6e-48 163.7 0.3 9.4e-46 156.7 0.3 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA04977.1 - 5.3e-10 39.8 0.0 1.8e-07 31.5 0.0 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EEA04977.1 - 0.012 16.1 0.0 9.8 6.8 0.0 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EEA04977.1 - 0.015 15.9 0.0 1.7 9.4 0.0 2.7 2 1 0 2 2 2 0 Aspartyl protease Tcf25 PF04910.14 EEA04978.1 - 5.3e-51 173.8 5.6 5.3e-51 173.8 5.6 1.9 2 0 0 2 2 2 1 Transcriptional repressor TCF25 PRELI PF04707.14 EEA04979.1 - 9.3e-34 116.5 0.1 1.7e-33 115.7 0.1 1.4 1 0 0 1 1 1 1 PRELI-like family MatP PF06303.12 EEA04979.1 - 0.012 16.1 0.1 0.049 14.2 0.1 2.0 1 0 0 1 1 1 0 MatP N-terminal domain zf-HIT PF04438.16 EEA04980.1 - 0.0001 22.1 18.2 0.0001 22.1 18.2 1.8 2 0 0 2 2 2 1 HIT zinc finger PolC_DP2 PF03833.13 EEA04980.1 - 0.35 8.7 2.0 0.43 8.4 2.0 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-MYND PF01753.18 EEA04980.1 - 0.57 10.3 20.2 1.4 9.1 20.2 1.7 1 0 0 1 1 1 0 MYND finger zf-CCCH PF00642.24 EEA04981.1 - 7.3e-05 22.6 4.2 0.003 17.4 0.1 4.3 4 1 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EEA04981.1 - 0.0052 17.0 0.1 0.013 15.7 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger containing family ADPRTs_Tse2 PF18648.1 EEA04981.1 - 0.093 12.8 0.0 0.77 9.8 0.1 2.0 2 0 0 2 2 2 0 Tse2 ADP-ribosyltransferase toxins Gemini_AL1_M PF08283.11 EEA04982.1 - 0.025 14.7 0.5 0.025 14.7 0.5 1.5 2 0 0 2 2 2 0 Geminivirus rep protein central domain Peptidase_C28 PF05408.11 EEA04982.1 - 0.083 12.6 0.0 0.12 12.1 0.0 1.3 1 1 0 1 1 1 0 Foot-and-mouth virus L-proteinase DUF4533 PF15047.6 EEA04982.1 - 0.11 12.0 0.4 0.18 11.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) DUF2070 PF09843.9 EEA04983.1 - 0.0047 15.3 1.1 0.0051 15.2 1.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) DUF2721 PF11026.8 EEA04983.1 - 0.19 11.6 3.6 0.34 10.8 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Synaptobrevin PF00957.21 EEA04984.1 - 4.9e-09 35.8 0.6 6.4e-09 35.5 0.6 1.1 1 0 0 1 1 1 1 Synaptobrevin Sec8_exocyst PF04048.14 EEA04984.1 - 0.042 13.7 0.6 0.05 13.5 0.5 1.3 1 1 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF2937 PF11157.8 EEA04984.1 - 0.16 11.7 0.2 0.26 11.0 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) DUF3883 PF13020.6 EEA04985.1 - 1.2e-21 76.6 0.2 3e-21 75.2 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) Steroid_dh PF02544.16 EEA04986.1 - 6.9e-16 58.6 9.2 6.9e-16 58.6 9.2 2.2 1 1 2 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase SVM_signal PF12113.8 EEA04986.1 - 0.16 11.9 0.4 0.16 11.9 0.4 2.3 2 0 0 2 2 2 0 SVM protein signal sequence RRM_1 PF00076.22 EEA04987.1 - 1.4e-14 53.6 0.0 2.2e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Actin PF00022.19 EEA04988.1 - 4.4e-72 242.9 0.0 2.6e-70 237.1 0.0 2.0 1 1 0 1 1 1 1 Actin CS PF04969.16 EEA04989.1 - 5e-05 24.2 0.0 0.00021 22.3 0.0 2.1 1 1 0 1 1 1 1 CS domain KleE PF17394.2 EEA04989.1 - 0.1 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein FAD-SLDH PF12318.8 EEA04989.1 - 0.15 12.1 0.4 0.39 10.8 0.1 1.7 2 1 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase Guanylate_cyc PF00211.20 EEA04990.1 - 2.9e-33 115.0 0.0 6.1e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.31 EEA04990.1 - 0.0053 16.0 9.9 0.0053 16.0 9.9 2.6 2 1 1 3 3 3 1 Ion transport protein EF-hand_6 PF13405.6 EEA04990.1 - 0.018 15.0 0.0 0.1 12.6 0.0 2.4 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 EEA04990.1 - 0.021 14.3 0.1 0.29 10.8 0.0 2.6 2 0 0 2 2 2 0 EF hand TPR_12 PF13424.6 EEA04991.1 - 1.7e-08 34.7 8.3 0.34 11.2 0.0 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA04991.1 - 1.7e-08 33.9 9.1 1.5 9.0 0.1 7.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA04991.1 - 2.5e-06 27.2 21.3 0.46 10.7 0.1 9.4 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA04991.1 - 2e-05 24.2 24.0 0.079 12.8 0.7 7.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA04991.1 - 0.00015 22.1 7.4 13 6.6 0.1 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA04991.1 - 0.00017 21.7 19.6 0.18 12.1 1.4 6.5 5 2 3 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EEA04991.1 - 0.0003 21.2 4.0 3.1 8.4 0.1 5.2 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA04991.1 - 0.00052 20.1 0.3 1.2 9.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA04991.1 - 0.0029 18.3 0.0 2.9 8.9 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EEA04991.1 - 0.011 16.2 0.8 3.1 8.2 0.0 3.2 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_8 PF13181.6 EEA04991.1 - 0.02 15.0 33.3 0.1 12.9 0.4 8.8 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_10 PF13374.6 EEA04991.1 - 0.028 14.3 7.5 3 7.8 0.5 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA04991.1 - 0.096 13.3 1.0 41 4.9 0.3 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat RPN7 PF10602.9 EEA04991.1 - 0.11 12.1 10.0 2.3 7.9 0.2 4.3 3 1 1 4 4 4 0 26S proteasome subunit RPN7 Sec62 PF03839.16 EEA04992.1 - 2.7e-26 92.4 6.1 3.6e-26 92.0 6.1 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 DHHC PF01529.20 EEA04993.1 - 1.4e-30 106.1 17.0 1.4e-30 106.1 17.0 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase PGG PF13962.6 EEA04993.1 - 1.2 8.9 7.2 3 7.7 7.2 1.6 1 0 0 1 1 1 0 Domain of unknown function Dymeclin PF09742.9 EEA04994.1 - 1.7e-95 320.8 18.7 2.7e-95 320.1 18.7 1.3 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Pkinase PF00069.25 EEA04995.1 - 3.8e-60 203.5 0.0 5.6e-60 202.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA04995.1 - 9.6e-27 93.9 0.0 1.4e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA04995.1 - 1.1e-05 25.0 0.0 0.0017 17.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EEA04995.1 - 0.22 11.4 0.0 0.38 10.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIBIOP_C PF04950.12 EEA04996.1 - 4.9e-93 311.7 0.4 1.1e-92 310.7 0.4 1.6 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EEA04996.1 - 3.2e-16 59.2 0.0 9.7e-16 57.6 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain DUF4144 PF13642.6 EEA04996.1 - 0.2 12.2 0.8 0.57 10.8 0.8 1.8 1 0 0 1 1 1 0 protein structure with unknown function FERM_N_2 PF18038.1 EEA04996.1 - 1.5 9.7 4.3 9.8 7.1 0.0 3.3 3 0 0 3 3 3 0 FERM N-terminal domain RNA_pol_Rpc4 PF05132.14 EEA04997.1 - 2.3e-07 31.4 0.2 4.5e-06 27.2 0.0 2.2 1 1 1 2 2 2 1 RNA polymerase III RPC4 DUF3439 PF11921.8 EEA04998.1 - 0.01 15.8 5.4 0.01 15.8 5.4 29.4 12 5 2 14 14 14 0 Domain of unknown function (DUF3439) zf-B_box PF00643.24 EEA04999.1 - 6.4e-07 29.4 34.0 1.3e-06 28.4 6.7 6.7 4 0 0 4 4 4 2 B-box zinc finger zf-RING_2 PF13639.6 EEA04999.1 - 8.3 6.8 40.2 0.035 14.5 8.4 4.0 3 0 0 3 3 3 0 Ring finger domain RRM_1 PF00076.22 EEA05000.1 - 2.1e-18 65.9 0.5 6.2e-13 48.4 0.1 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EEA05000.1 - 1.4e-05 24.9 0.1 0.0014 18.4 0.0 2.7 1 1 1 2 2 2 1 Rrp7 RRM-like N-terminal domain SAGA-Tad1 PF12767.7 EEA05000.1 - 0.032 14.0 4.3 0.065 13.0 4.3 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PMBR PF09373.10 EEA05000.1 - 0.039 14.1 1.3 0.17 12.1 0.3 2.5 2 0 0 2 2 2 0 Pseudomurein-binding repeat PHM7_cyt PF14703.6 EEA05000.1 - 0.046 14.0 1.9 6.7 6.9 0.0 3.3 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Topoisom_bac PF01131.20 EEA05001.1 - 4.8e-105 351.9 0.0 3.9e-103 345.6 0.0 2.1 1 1 1 2 2 2 2 DNA topoisomerase Toprim PF01751.22 EEA05001.1 - 1.1e-14 54.5 0.0 2.6e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Toprim domain Lactamase_B_6 PF16661.5 EEA05002.1 - 3.6e-21 75.5 0.1 1.1e-20 73.9 0.1 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EEA05002.1 - 2.2e-20 73.0 0.0 7.9e-20 71.2 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 EEA05002.1 - 2.5e-12 46.5 0.0 5.9e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EEA05002.1 - 6.1e-12 46.0 0.5 1.1e-07 32.1 0.2 2.5 2 1 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EEA05002.1 - 2e-05 24.2 0.0 9.7e-05 22.0 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EEA05002.1 - 5e-05 22.6 0.8 0.00021 20.6 0.0 2.3 3 0 0 3 3 3 1 Putative beta-lactamase-like family Lactamase_B_3 PF13483.6 EEA05002.1 - 0.00016 21.6 0.2 0.0016 18.4 0.1 2.6 2 1 0 2 2 2 1 Beta-lactamase superfamily domain BTB PF00651.31 EEA05003.1 - 2.6e-08 34.0 0.0 6.1e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Med26 PF08711.11 EEA05004.1 - 5.7e-07 29.5 0.7 1.4e-06 28.2 0.7 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Cloacin_immun PF03513.14 EEA05004.1 - 0.0059 16.9 0.1 0.051 13.9 0.0 2.5 2 0 0 2 2 2 1 Cloacin immunity protein Epimerase PF01370.21 EEA05005.1 - 4.6e-27 95.0 0.1 1.1e-26 93.8 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EEA05005.1 - 5.1e-20 71.7 0.0 2e-18 66.5 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EEA05005.1 - 6.1e-18 64.8 0.0 1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EEA05005.1 - 3.6e-15 56.2 0.0 5.5e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EEA05005.1 - 2.6e-14 53.5 0.0 3.9e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EEA05005.1 - 1.4e-07 31.4 0.0 3.8e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EEA05005.1 - 1.4e-06 27.7 0.0 3e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EEA05005.1 - 0.0032 17.4 0.0 0.02 14.8 0.0 2.1 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EEA05005.1 - 0.013 14.6 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short PF00106.25 EEA05005.1 - 0.04 13.4 0.0 0.38 10.2 0.0 2.3 1 1 0 1 1 1 0 short chain dehydrogenase WD40 PF00400.32 EEA05006.1 - 1.1e-29 102.1 14.5 0.0012 19.6 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.11 EEA05006.1 - 2.5e-11 42.9 0.0 5.3e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EEA05006.1 - 9.8e-10 38.6 0.9 0.81 10.0 0.1 5.0 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA05006.1 - 0.00025 20.1 0.2 0.64 8.9 0.0 3.3 2 2 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EEA05006.1 - 0.047 12.3 0.0 0.81 8.3 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Exo_endo_phos_2 PF14529.6 EEA05006.1 - 0.056 13.3 0.4 0.12 12.2 0.4 1.5 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Nbas_N PF15492.6 EEA05006.1 - 0.083 12.2 0.0 18 4.5 0.0 3.2 4 0 0 4 4 4 0 Neuroblastoma-amplified sequence, N terminal SANT_DAMP1_like PF16282.5 EEA05007.1 - 6.1e-29 100.1 2.1 1.7e-28 98.6 2.1 1.8 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 EEA05007.1 - 0.005 17.1 0.0 0.022 15.0 0.0 2.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Transposase_22 PF02994.14 EEA05007.1 - 0.11 12.7 0.3 0.91 9.7 0.1 2.6 2 0 0 2 2 2 0 L1 transposable element RBD-like domain SSXT PF05030.12 EEA05008.1 - 0.00039 20.0 0.2 0.0011 18.6 0.2 1.8 1 0 0 1 1 1 1 SSXT protein (N-terminal region) zf-C2H2 PF00096.26 EEA05008.1 - 0.0044 17.4 3.8 0.017 15.6 3.8 2.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 EEA05008.1 - 0.016 14.8 0.6 0.041 13.5 0.6 1.7 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_4 PF13894.6 EEA05008.1 - 0.08 13.8 2.9 0.34 11.9 2.9 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger Orthopox_F8 PF05886.11 EEA05009.1 - 0.021 15.0 0.3 0.047 13.8 0.3 1.5 1 0 0 1 1 1 0 Orthopoxvirus F8 protein ESCRT-II PF05871.12 EEA05010.1 - 0.31 11.3 3.7 11 6.3 0.1 2.6 3 0 0 3 3 3 0 ESCRT-II complex subunit Acyltransferase PF01553.21 EEA05011.1 - 1.3e-12 47.5 0.0 4.1e-12 45.9 0.0 1.8 1 1 1 2 2 2 1 Acyltransferase Torus PF16131.5 EEA05012.1 - 5.8e-12 46.3 14.2 5.1e-05 23.9 2.0 3.5 1 1 2 3 3 3 3 Torus domain zf_CCCH_4 PF18345.1 EEA05012.1 - 4.4e-11 42.4 25.1 9.7e-06 25.5 2.7 4.4 3 1 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 EEA05012.1 - 9.3e-09 34.9 26.4 0.00019 21.1 0.9 4.6 4 1 0 4 4 4 3 CCCH-type zinc finger zf-CCCH PF00642.24 EEA05012.1 - 9.3e-06 25.4 22.8 0.00039 20.2 3.1 3.9 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EEA05012.1 - 0.00047 20.5 18.5 0.004 17.6 0.4 4.2 3 1 0 3 3 3 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EEA05012.1 - 0.012 15.8 13.7 0.3 11.3 5.0 2.8 1 1 1 2 2 2 0 Zinc-finger containing family Occludin_ELL PF07303.13 EEA05013.1 - 0.0024 18.5 9.0 0.0024 18.5 9.0 5.5 2 1 4 6 6 6 2 Occludin homology domain Sec34 PF04136.15 EEA05013.1 - 0.0068 16.3 31.4 0.069 13.0 10.4 4.7 3 2 1 4 4 4 2 Sec34-like family PH PF00169.29 EEA05013.1 - 0.1 13.1 2.0 0.3 11.6 0.3 2.8 2 1 0 2 2 2 0 PH domain Spc7 PF08317.11 EEA05013.1 - 0.11 11.3 47.8 0.054 12.4 13.4 4.0 1 1 3 4 4 4 0 Spc7 kinetochore protein V-SNARE_C PF12352.8 EEA05013.1 - 0.37 11.1 0.0 0.37 11.1 0.0 3.8 4 0 0 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus DUF1664 PF07889.12 EEA05013.1 - 3.4 7.7 26.3 13 5.8 7.4 4.9 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EEA05013.1 - 5.3 7.4 14.8 9.3 6.6 1.6 4.4 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EEA05013.1 - 8.2 7.0 11.4 1.2 9.7 0.7 3.9 3 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Taxilin PF09728.9 EEA05013.1 - 8.7 5.4 58.8 0.04 13.1 40.1 3.0 1 1 2 3 3 3 0 Myosin-like coiled-coil protein ArfGap PF01412.18 EEA05014.1 - 1.5e-29 102.5 1.8 1.8e-29 102.2 0.2 1.9 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf DUF1841 PF08897.11 EEA05015.1 - 0.032 14.3 0.3 0.076 13.0 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) SYCE1 PF15233.6 EEA05015.1 - 5.4 7.1 7.9 0.47 10.5 1.4 2.4 3 0 0 3 3 3 0 Synaptonemal complex central element protein 1 Mg_trans_NIPA PF05653.14 EEA05016.1 - 1.4e-17 63.7 16.5 1.1e-09 37.9 3.5 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA SieB PF14163.6 EEA05016.1 - 0.0001 21.8 1.4 0.052 13.0 0.0 2.8 2 0 0 2 2 2 2 Super-infection exclusion protein B Shisa PF13908.6 EEA05016.1 - 0.023 14.9 0.2 2.2 8.5 0.0 2.6 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator UPF0239 PF06783.11 EEA05016.1 - 0.079 13.2 0.3 1.7 8.9 0.0 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) EamA PF00892.20 EEA05016.1 - 3.7 7.7 24.2 0.1 12.8 5.1 3.9 4 0 0 4 4 4 0 EamA-like transporter family Imm39 PF15568.6 EEA05017.1 - 0.061 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 39 B-block_TFIIIC PF04182.12 EEA05019.1 - 1.7e-19 69.8 0.3 2.5e-14 53.2 0.0 3.4 2 0 0 2 2 2 2 B-block binding subunit of TFIIIC TFIIE_alpha PF02002.17 EEA05019.1 - 0.0024 17.7 0.7 0.055 13.3 0.1 3.4 3 0 0 3 3 3 1 TFIIE alpha subunit HTH_5 PF01022.20 EEA05019.1 - 0.003 17.4 0.8 0.12 12.3 0.0 3.6 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family KASH_CCD PF14662.6 EEA05020.1 - 0.03 14.2 1.5 0.046 13.6 0.6 1.7 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Ribosomal_L13 PF00572.18 EEA05021.1 - 1.3e-07 31.9 0.2 2.7e-05 24.4 0.0 2.8 2 1 0 2 2 2 1 Ribosomal protein L13 TLD PF07534.16 EEA05022.1 - 2.1e-30 105.8 1.0 3.3e-14 53.3 0.1 2.3 1 1 0 2 2 2 2 TLD PCI PF01399.27 EEA05023.1 - 1.8e-09 38.0 0.1 6.8e-09 36.2 0.0 2.1 2 0 0 2 2 2 1 PCI domain CoA_binding PF02629.19 EEA05024.1 - 5.6e-23 81.4 0.7 1.6e-22 80.0 0.7 1.8 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 EEA05024.1 - 2.3e-21 76.2 0.1 4e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EEA05024.1 - 2.4e-07 30.6 0.2 8.4e-07 28.9 0.2 1.9 1 1 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EEA05024.1 - 0.086 13.3 0.1 0.24 11.9 0.0 1.7 2 0 0 2 2 2 0 CoA binding domain Histone PF00125.24 EEA05025.1 - 8.3e-15 55.3 0.0 1.1e-14 54.9 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EEA05025.1 - 6.1e-11 41.9 0.6 1.3e-10 40.9 0.6 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EEA05025.1 - 0.00046 20.4 0.0 0.00066 19.9 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Prefoldin PF02996.17 EEA05026.1 - 2.3e-19 69.5 0.2 2.8e-19 69.2 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit PRP1_N PF06424.12 EEA05028.1 - 7.2e-30 104.3 4.7 2.2e-29 102.8 4.7 1.8 1 1 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EEA05028.1 - 1.6e-19 68.9 6.0 0.047 14.5 0.1 9.9 6 2 4 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 EEA05028.1 - 7.6e-14 52.0 1.0 5.5e-06 26.8 0.0 6.0 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA05028.1 - 4e-06 26.5 3.3 1.6 9.0 0.0 7.4 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 EEA05028.1 - 8.8e-06 25.1 1.0 0.0086 15.3 0.1 4.5 2 2 2 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.10 EEA05028.1 - 0.00047 19.3 4.2 0.038 13.0 0.0 4.1 4 1 0 5 5 5 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_16 PF13432.6 EEA05028.1 - 0.00049 20.7 0.0 9.9 6.9 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA05028.1 - 0.00062 19.8 0.2 19 5.8 0.0 5.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Suf PF05843.14 EEA05028.1 - 0.0011 19.0 1.6 1.7 8.6 0.0 3.9 4 1 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_1 PF00515.28 EEA05028.1 - 0.0017 18.1 0.3 41 4.2 0.0 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA05028.1 - 0.0017 18.6 3.4 18 5.7 0.0 6.1 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 EEA05028.1 - 0.0027 17.8 0.4 2 8.6 0.0 4.2 4 1 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA05028.1 - 0.0047 17.1 2.5 3 8.1 0.1 4.7 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EEA05028.1 - 0.0097 16.2 0.1 49 4.6 0.0 5.9 6 1 0 6 6 6 0 Tetratricopeptide repeat ParA PF10609.9 EEA05030.1 - 3.4e-68 229.7 0.0 1.2e-66 224.7 0.0 2.2 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 EEA05030.1 - 6.7e-16 58.2 0.0 6.8e-15 55.0 0.0 2.4 2 1 0 2 2 2 1 Iron-sulfur cluster assembly protein AAA_31 PF13614.6 EEA05030.1 - 7.7e-12 45.5 3.3 9e-12 45.3 0.2 2.7 3 1 0 3 3 3 1 AAA domain DUF971 PF06155.12 EEA05030.1 - 8.9e-11 42.3 0.1 2.2e-10 41.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CbiA PF01656.23 EEA05030.1 - 2.2e-09 37.4 0.0 4.7e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EEA05030.1 - 3.9e-05 23.1 0.0 6.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EEA05030.1 - 0.00067 18.9 0.6 0.039 13.1 0.2 2.5 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 EEA05030.1 - 0.0045 16.5 0.2 0.014 14.8 0.2 1.8 1 1 1 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 EEA05030.1 - 0.085 12.3 0.0 0.82 9.1 0.0 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 EEA05030.1 - 0.099 12.4 0.2 0.57 9.9 0.0 2.3 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Flt3_lig PF02947.14 EEA05031.1 - 0.013 15.7 0.4 3.7 7.8 0.1 3.8 2 1 1 3 3 3 0 flt3 ligand SNARE PF05739.19 EEA05032.1 - 7.4e-08 32.3 0.3 3.3e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EEA05032.1 - 0.021 14.5 6.9 1.2 8.7 6.9 2.5 1 1 0 1 1 1 0 Syntaxin RNA_polI_A14 PF08203.11 EEA05032.1 - 2.9 8.7 7.4 0.34 11.7 0.4 2.7 3 0 0 3 3 3 0 Yeast RNA polymerase I subunit RPA14 ATP-synt_F PF01990.17 EEA05034.1 - 6.2e-28 97.0 0.1 7.2e-28 96.7 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit PP2C PF00481.21 EEA05035.1 - 1.4e-39 136.3 0.0 1.8e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C rpo132 PF12415.8 EEA05035.1 - 0.16 11.2 0.2 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase AFG1_ATPase PF03969.16 EEA05036.1 - 4e-68 229.9 0.2 1e-50 172.7 0.2 2.1 1 1 0 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 EEA05036.1 - 3.5e-07 30.3 0.2 9.6e-07 28.9 0.2 1.6 1 0 0 1 1 1 1 Bacterial dnaA protein AAA PF00004.29 EEA05036.1 - 6.3e-06 26.6 0.2 3.3e-05 24.3 0.1 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA05036.1 - 3e-05 24.3 2.2 0.0072 16.6 0.8 3.8 3 1 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 EEA05036.1 - 0.00063 19.7 2.7 0.41 10.5 0.1 2.6 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EEA05036.1 - 0.0085 15.8 0.4 0.041 13.6 0.2 2.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EEA05036.1 - 0.011 16.1 0.0 0.066 13.6 0.0 2.1 2 1 1 3 3 3 0 AAA ATPase domain AAA_14 PF13173.6 EEA05036.1 - 0.018 15.1 2.6 0.023 14.7 0.3 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EEA05036.1 - 0.018 15.0 0.0 0.052 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EEA05036.1 - 0.037 14.4 0.2 0.13 12.6 0.1 2.2 2 1 0 2 2 2 0 RNA helicase Dynein_heavy PF03028.15 EEA05036.1 - 0.13 12.4 0.2 1.8 8.7 0.1 2.6 2 0 0 2 2 2 0 Dynein heavy chain region D6 P-loop domain NACHT PF05729.12 EEA05036.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 EEA05036.1 - 1.1 8.7 4.3 5.2 6.4 0.0 3.8 5 0 0 5 5 5 0 Bacterial TniB protein VCBS PF13517.6 EEA05037.1 - 1e-21 77.3 13.1 1.2e-06 29.0 0.6 6.4 4 2 3 7 7 7 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EEA05037.1 - 1.2e-07 31.8 19.0 0.25 11.5 0.2 6.6 7 0 0 7 7 7 4 FG-GAP repeat TcdB_toxin_midN PF12256.8 EEA05037.1 - 0.00016 21.1 0.3 2.6 7.4 0.0 5.4 5 1 1 6 6 6 1 Insecticide toxin TcdB middle/N-terminal region Evr1_Alr PF04777.13 EEA05037.1 - 0.09 13.2 0.5 1.9 9.0 0.1 2.6 2 0 0 2 2 2 0 Erv1 / Alr family EF-hand_1 PF00036.32 EEA05037.1 - 0.74 9.5 4.1 58 3.6 0.0 4.0 3 0 0 3 3 3 0 EF hand Pkinase PF00069.25 EEA05038.1 - 3.2e-81 272.6 0.0 5.6e-81 271.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05038.1 - 3.3e-41 141.3 0.0 5.3e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EEA05038.1 - 2e-28 95.8 10.9 1.1e-06 27.7 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EEA05038.1 - 6.6e-22 75.5 6.0 1.6e-05 24.5 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EEA05038.1 - 1e-20 73.9 6.1 1.8e-09 37.9 1.1 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA05038.1 - 1.2e-19 68.8 9.7 3.6e-05 23.0 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EEA05038.1 - 6.4e-16 57.9 12.0 0.0015 18.4 0.4 4.9 3 1 2 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA05038.1 - 2.7e-07 30.9 3.0 0.018 15.4 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Kinase-like PF14531.6 EEA05038.1 - 6.3e-07 29.0 0.0 2e-05 24.1 0.0 2.6 2 1 0 2 2 2 1 Kinase-like EF-hand_4 PF12763.7 EEA05038.1 - 2.7e-06 27.3 7.2 0.01 15.7 0.4 3.5 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Pkinase_fungal PF17667.1 EEA05038.1 - 5.7e-06 25.4 0.1 1e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA05038.1 - 0.0047 16.9 0.0 0.015 15.2 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA05038.1 - 0.0073 15.7 0.2 0.017 14.5 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_9 PF14658.6 EEA05038.1 - 0.023 15.0 0.2 0.3 11.4 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain RIO1 PF01163.22 EEA05038.1 - 0.04 13.5 1.2 0.11 12.1 0.4 2.0 1 1 1 2 2 2 0 RIO1 family CNOT1_CAF1_bind PF16415.5 EEA05038.1 - 0.094 12.1 0.9 0.14 11.5 0.1 1.6 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain LRR_4 PF12799.7 EEA05039.1 - 5.5e-15 55.2 30.9 3.1e-06 27.4 3.3 5.2 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA05039.1 - 2.3e-14 52.9 28.6 1.8e-07 30.8 6.3 5.1 4 0 0 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 EEA05039.1 - 0.00071 19.1 5.7 0.031 13.8 0.7 3.1 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 EEA05039.1 - 0.0026 18.1 30.3 2 9.3 0.2 8.8 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 EEA05039.1 - 0.033 14.2 24.4 0.15 12.1 0.9 7.0 7 0 0 7 7 7 0 Leucine Rich repeat DUF155 PF02582.14 EEA05040.1 - 2e-37 129.0 0.0 3.5e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Glyco_transf_92 PF01697.27 EEA05041.1 - 4.7e-20 72.3 2.2 6.5e-19 68.6 2.2 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 EEA05041.1 - 0.00087 19.8 0.0 0.0034 17.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 2 C2 PF00168.30 EEA05042.1 - 2e-10 40.8 0.1 2e-06 28.0 0.0 4.5 3 1 0 3 3 3 2 C2 domain Malic_M PF03949.15 EEA05044.1 - 2.4e-84 282.7 0.0 2.9e-84 282.4 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EEA05044.1 - 1.4e-59 200.9 0.0 2.2e-59 200.3 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain CAF1C_H4-bd PF12265.8 EEA05047.1 - 7.9e-22 77.3 3.3 2.9e-21 75.5 0.3 2.9 4 0 0 4 4 4 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EEA05047.1 - 2.1e-13 50.5 13.9 0.00086 20.1 0.2 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat RNA_pol_Rpb1_5 PF04998.17 EEA05048.1 - 1.6e-80 270.4 0.0 3.1e-80 269.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EEA05048.1 - 1.8e-58 197.4 0.2 4.7e-58 196.1 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EEA05048.1 - 4.7e-31 107.9 0.2 1.6e-30 106.1 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EEA05048.1 - 6.4e-27 94.7 0.7 9.2e-26 90.9 0.0 3.2 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EEA05048.1 - 1.1e-16 60.7 0.3 6.3e-16 58.3 0.3 2.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Glyco_transf_5 PF08323.11 EEA05049.1 - 2.1e-57 194.6 0.0 3.3e-57 194.0 0.0 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EEA05049.1 - 3.4e-14 52.7 0.0 5.9e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA05049.1 - 3.6e-12 46.9 0.0 1.2e-08 35.5 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferases group 1 Choline_kinase PF01633.20 EEA05050.1 - 2e-42 145.2 0.3 3.3e-42 144.5 0.3 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EEA05050.1 - 1.8e-06 28.0 0.0 5.7e-06 26.4 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EEA05050.1 - 0.0016 17.9 0.1 0.11 11.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain YIF1 PF03878.15 EEA05051.1 - 6.7e-36 124.0 9.7 8.5e-36 123.7 9.7 1.1 1 0 0 1 1 1 1 YIF1 TctB PF07331.11 EEA05051.1 - 0.23 11.8 9.7 0.47 10.7 9.7 1.5 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Yip1 PF04893.17 EEA05051.1 - 5.3 6.7 20.9 19 4.9 20.9 1.9 1 1 0 1 1 1 0 Yip1 domain RRM_1 PF00076.22 EEA05052.1 - 1.7e-36 123.9 0.0 2.7e-20 72.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA05052.1 - 1.8e-10 40.8 0.1 0.00012 22.1 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EEA05052.1 - 4.1e-05 23.5 0.1 0.16 12.0 0.0 2.9 2 1 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EEA05052.1 - 0.016 15.1 0.0 4.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EEA05052.1 - 0.054 13.7 0.0 19 5.5 0.0 2.8 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Laminin_G_1 PF00054.23 EEA05052.1 - 0.071 13.3 0.0 1.5 9.1 0.0 2.3 2 0 0 2 2 2 0 Laminin G domain RL PF17797.1 EEA05052.1 - 0.084 12.8 1.0 7.4 6.6 0.0 2.7 3 0 0 3 3 3 0 RL domain CSD PF00313.22 EEA05052.1 - 0.2 11.6 0.3 14 5.6 0.0 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain Glycos_transf_2 PF00535.26 EEA05053.1 - 1.1e-28 100.2 0.0 2e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EEA05053.1 - 3.7e-15 56.3 0.6 5.8e-15 55.7 0.6 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EEA05053.1 - 6.5e-10 38.5 0.1 1.6e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 EEA05053.1 - 5.1e-07 29.8 0.0 1.3e-06 28.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EEA05053.1 - 0.00069 19.2 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF4083 PF13314.6 EEA05053.1 - 0.047 13.6 0.8 0.1 12.6 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) WD40 PF00400.32 EEA05054.1 - 7.8e-16 58.2 10.2 0.0011 19.7 0.0 5.6 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA05054.1 - 2.3e-07 31.0 0.0 0.012 15.9 0.0 4.3 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EEA05054.1 - 0.0019 17.8 0.0 0.0032 17.1 0.0 1.5 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.5 EEA05054.1 - 0.0086 15.1 0.1 4.2 6.2 0.0 2.7 3 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EEA05054.1 - 0.04 14.4 0.0 2.4 8.8 0.0 3.3 3 0 0 3 3 3 0 PQQ-like domain TIP49 PF06068.13 EEA05055.1 - 2.6e-150 500.5 1.9 3.3e-150 500.2 1.9 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EEA05055.1 - 7.4e-21 74.1 1.5 1.7e-20 72.9 1.5 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EEA05055.1 - 1.6e-11 44.8 0.4 1.3e-07 32.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA05055.1 - 4.5e-09 36.3 0.9 9e-05 22.3 0.1 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EEA05055.1 - 1.7e-06 28.1 0.1 0.0021 18.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) DnaB_C PF03796.15 EEA05055.1 - 2.2e-06 27.2 0.4 4.6e-06 26.1 0.4 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EEA05055.1 - 4e-06 27.3 0.3 9.9e-06 26.0 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EEA05055.1 - 4.1e-05 24.0 1.2 0.00052 20.4 1.2 2.3 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EEA05055.1 - 8.5e-05 22.0 0.9 0.019 14.3 0.3 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EEA05055.1 - 0.00012 21.8 0.3 0.066 12.9 0.1 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 EEA05055.1 - 0.00017 21.9 0.1 0.42 10.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 EEA05055.1 - 0.00023 21.6 0.5 0.00064 20.2 0.1 2.1 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EEA05055.1 - 0.00082 18.7 0.1 0.0017 17.7 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 EEA05055.1 - 0.001 18.7 0.0 0.0022 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 EEA05055.1 - 0.0018 18.2 0.7 0.058 13.2 0.0 2.7 3 1 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein ATPase PF06745.13 EEA05055.1 - 0.0028 17.0 0.1 0.0049 16.3 0.1 1.4 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.9 EEA05055.1 - 0.0031 16.8 0.0 0.0064 15.8 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EEA05055.1 - 0.0039 17.1 0.0 0.0077 16.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Parvo_NS1 PF01057.17 EEA05055.1 - 0.0056 15.8 0.1 0.0091 15.1 0.1 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 PIF1 PF05970.14 EEA05055.1 - 0.0071 15.6 0.4 2.3 7.3 0.1 2.2 2 0 0 2 2 2 2 PIF1-like helicase IstB_IS21 PF01695.17 EEA05055.1 - 0.011 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 EEA05055.1 - 0.012 15.3 0.3 0.18 11.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EEA05055.1 - 0.015 14.8 0.1 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EEA05055.1 - 0.019 15.0 0.1 0.049 13.6 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EEA05055.1 - 0.026 15.0 0.2 0.15 12.6 0.1 2.4 2 1 0 2 2 1 0 AAA domain GvpD PF07088.11 EEA05055.1 - 0.039 12.6 0.0 0.076 11.6 0.0 1.4 1 0 0 1 1 1 0 GvpD gas vesicle protein DNA_pol3_delta2 PF13177.6 EEA05055.1 - 0.044 13.6 0.2 0.22 11.3 0.0 2.1 2 1 0 2 2 2 0 DNA polymerase III, delta subunit RNA_helicase PF00910.22 EEA05055.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_28 PF13521.6 EEA05055.1 - 0.057 13.7 0.2 0.3 11.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 EEA05055.1 - 0.082 13.0 0.7 0.74 9.9 0.1 2.6 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) PhoH PF02562.16 EEA05055.1 - 0.21 11.0 3.7 0.36 10.2 0.4 2.6 3 0 0 3 3 3 0 PhoH-like protein DUF5446 PF17522.2 EEA05055.1 - 0.31 11.2 2.0 10 6.4 0.6 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Thioredoxin PF00085.20 EEA05056.1 - 2.1e-14 53.4 0.9 4.1e-14 52.4 0.8 1.6 1 1 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EEA05056.1 - 0.0043 17.0 0.2 0.0071 16.3 0.2 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EEA05056.1 - 0.0094 16.3 0.1 0.019 15.3 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EEA05056.1 - 0.033 14.4 0.2 0.063 13.5 0.2 1.5 1 0 0 1 1 1 0 Thioredoxin-like PyocinActivator PF11112.8 EEA05056.1 - 0.069 13.3 0.3 0.44 10.7 0.0 2.3 2 1 1 3 3 3 0 Pyocin activator protein PrtN Thioredoxin_2 PF13098.6 EEA05056.1 - 0.086 13.3 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain IMCp PF12314.8 EEA05058.1 - 1.1e-26 92.9 107.3 1.8e-12 47.4 27.5 5.9 1 1 4 5 5 5 5 Inner membrane complex protein Ank_2 PF12796.7 EEA05059.1 - 1e-23 83.7 3.5 5.7e-13 49.3 0.0 3.3 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA05059.1 - 1.1e-23 83.2 2.6 3.5e-10 40.2 0.0 4.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA05059.1 - 5.4e-17 60.2 0.8 1.3e-05 25.2 0.0 5.3 7 0 0 7 7 7 3 Ankyrin repeat Bromodomain PF00439.25 EEA05059.1 - 3.4e-16 59.1 0.2 8e-16 57.9 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Ank_5 PF13857.6 EEA05059.1 - 1.1e-13 51.1 1.1 4.6e-10 39.6 0.3 2.9 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA05059.1 - 4.5e-13 49.0 2.0 2.4e-05 24.6 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat Lipase_GDSL_2 PF13472.6 EEA05059.1 - 0.043 14.2 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF5633 PF18656.1 EEA05059.1 - 0.07 13.0 0.1 0.23 11.4 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5633) Ala_racemase_N PF01168.20 EEA05060.1 - 1.8e-15 57.2 0.0 2.2e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Baculo_LEF5 PF04838.12 EEA05060.1 - 0.065 13.3 1.9 0.079 13.0 0.1 1.9 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 ThiF PF00899.21 EEA05060.1 - 0.12 11.7 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 ThiF family Nucleo_LEF-12 PF06256.11 EEA05060.1 - 0.19 11.5 1.3 5 6.8 0.1 2.3 1 1 2 3 3 3 0 Nucleopolyhedrovirus LEF-12 protein tRNA-synt_1 PF00133.22 EEA05061.1 - 6.5e-39 133.7 0.0 3.2e-20 71.9 0.0 3.7 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EEA05061.1 - 4.5e-19 68.5 6.2 1.9e-11 43.4 0.0 3.3 4 0 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EEA05061.1 - 1.9e-12 47.4 0.7 5.4e-12 45.9 0.7 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EEA05061.1 - 7.1e-10 38.7 0.0 8.5e-09 35.2 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Mo-nitro_C PF06967.11 EEA05061.1 - 0.12 12.3 0.0 0.44 10.5 0.0 1.9 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus Actin PF00022.19 EEA05062.1 - 1.6e-43 148.9 0.0 1.3e-42 145.9 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA05062.1 - 0.11 11.2 0.1 1.3 7.7 0.0 2.2 2 1 0 2 2 2 0 MreB/Mbl protein DUF1279 PF06916.13 EEA05063.1 - 9.3e-16 58.2 0.2 1.6e-15 57.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) TM1586_NiRdase PF14512.6 EEA05063.1 - 0.012 15.2 0.4 0.016 14.7 0.4 1.2 1 0 0 1 1 1 0 Putative TM nitroreductase RXLR PF16810.5 EEA05064.1 - 0.59 10.6 5.0 1.2 9.6 0.4 2.6 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity zf-C3Hc3H PF13891.6 EEA05064.1 - 6 7.3 6.0 3.5 8.1 0.3 2.7 3 0 0 3 3 3 0 Potential DNA-binding domain zf-MYND PF01753.18 EEA05065.1 - 2.3e-07 30.8 6.6 4.8e-07 29.8 6.6 1.5 1 0 0 1 1 1 1 MYND finger HMW1C_N PF18071.1 EEA05065.1 - 0.021 14.6 0.2 0.14 11.9 0.1 2.2 2 0 0 2 2 2 0 HMW1C N-terminal Beta-Casp PF10996.8 EEA05066.1 - 0.00011 22.5 0.0 0.00047 20.4 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain Fringe PF02434.16 EEA05067.1 - 5.4e-21 75.2 0.1 5.7e-19 68.5 0.1 3.0 2 1 0 2 2 2 1 Fringe-like YonK PF09642.10 EEA05067.1 - 0.13 12.4 0.1 0.54 10.4 0.1 2.0 1 0 0 1 1 1 0 YonK protein ATP-synt_D PF01813.17 EEA05068.1 - 8.2e-62 208.5 0.8 9.7e-62 208.3 0.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit D DUF3967 PF13152.6 EEA05068.1 - 0.024 14.4 2.7 0.27 11.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3967) ATP_bind_3 PF01171.20 EEA05069.1 - 3.5e-14 53.0 0.0 6e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EEA05069.1 - 8.8e-13 47.5 4.0 8.8e-13 47.5 4.0 2.9 4 0 0 4 4 4 1 Zinc-ribbon Symplekin_C PF12295.8 EEA05070.1 - 7.2e-35 120.8 0.7 6.4e-34 117.7 0.0 2.9 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal Corona_NS2 PF04753.12 EEA05070.1 - 0.092 13.3 0.0 17 6.1 0.0 3.1 3 0 0 3 3 3 0 Coronavirus non-structural protein NS2 tRNA_m1G_MT PF01746.21 EEA05071.1 - 2.9e-12 46.7 0.1 3.9e-12 46.3 0.1 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase GDPD PF03009.17 EEA05072.1 - 2.1e-26 93.2 0.0 1.3e-24 87.3 0.0 2.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EEA05072.1 - 0.0023 18.3 0.0 0.0049 17.3 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Proteasom_Rpn13 PF04683.13 EEA05073.1 - 3.8e-15 56.2 0.0 6.2e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EEA05073.1 - 9.3e-14 51.6 1.4 1.5e-13 50.9 1.4 1.3 1 0 0 1 1 1 1 UCH-binding domain Phage_min_cap2 PF06152.11 EEA05073.1 - 0.068 12.1 0.5 0.094 11.6 0.5 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 Spo0A_C PF08769.11 EEA05073.1 - 0.073 13.2 0.0 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal DUF1479 PF07350.12 EEA05073.1 - 0.089 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) RNA_pol_Rpb1_5 PF04998.17 EEA05073.1 - 0.16 11.4 0.5 0.27 10.6 0.3 1.5 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF4300 PF14133.6 EEA05074.1 - 0.022 14.4 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) SWC7 PF17330.2 EEA05074.1 - 0.034 14.2 0.1 0.057 13.5 0.1 1.5 1 0 0 1 1 1 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 Hydrolase_4 PF12146.8 EEA05075.1 - 1.1e-07 31.4 0.0 0.0012 18.1 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA05075.1 - 5.8e-06 26.1 0.1 0.00062 19.5 0.0 2.9 3 1 1 4 4 4 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EEA05075.1 - 0.00039 20.3 0.8 0.038 13.8 0.0 2.7 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA05075.1 - 0.00054 19.5 0.6 0.0086 15.6 0.0 2.6 3 0 0 3 3 3 1 Prolyl oligopeptidase family FSH1 PF03959.13 EEA05075.1 - 0.0052 16.5 0.0 0.026 14.2 0.0 2.1 1 1 1 2 2 2 1 Serine hydrolase (FSH1) DUF1749 PF08538.10 EEA05076.1 - 0.16 11.1 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) zf-C3HC4_3 PF13920.6 EEA05077.1 - 5e-08 32.7 11.5 8e-06 25.6 11.5 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA05077.1 - 2.1e-07 30.7 10.2 3.9e-06 26.6 6.6 2.4 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA05077.1 - 8.2e-07 28.9 11.1 8.1e-06 25.7 7.0 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EEA05077.1 - 8.9e-07 28.7 8.5 8.7e-06 25.5 8.6 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA05077.1 - 4e-06 27.1 12.4 0.00014 22.2 12.4 2.6 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EEA05077.1 - 3.3e-05 23.8 7.7 0.0001 22.2 7.7 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EEA05077.1 - 0.00016 21.5 8.7 0.0025 17.6 5.6 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EEA05077.1 - 0.00037 20.2 3.7 0.00037 20.2 3.7 2.4 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EEA05077.1 - 0.018 15.2 4.2 0.018 15.2 4.2 2.8 2 1 2 4 4 3 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.14 EEA05077.1 - 0.021 14.5 2.9 0.021 14.5 2.9 2.6 3 0 0 3 3 3 0 P-11 zinc finger zf-rbx1 PF12678.7 EEA05077.1 - 0.054 13.8 10.5 0.19 12.0 10.5 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain DUF4897 PF16238.5 EEA05077.1 - 0.077 12.8 1.5 0.13 12.1 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) Arylsulfotran_N PF17425.2 EEA05077.1 - 0.084 12.9 0.1 0.9 9.6 0.1 2.3 1 1 0 1 1 1 0 Arylsulfotransferase Ig-like domain zf-ANAPC11 PF12861.7 EEA05077.1 - 0.16 12.1 6.3 0.62 10.2 6.2 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-MIZ PF02891.20 EEA05077.1 - 1.1 9.0 7.7 28 4.6 5.6 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_10 PF16685.5 EEA05077.1 - 3.5 7.8 14.8 0.052 13.7 6.8 2.1 2 1 0 2 2 1 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 EEA05077.1 - 6.4 6.8 10.2 6.8 6.7 6.0 2.7 2 1 1 3 3 3 0 zinc-ribbons CAP_C PF08603.11 EEA05078.1 - 2.8e-48 163.5 12.5 3.4e-48 163.2 12.5 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EEA05078.1 - 2.9e-07 30.2 13.6 6.8e-07 29.0 13.7 1.5 1 1 0 1 1 1 1 Tubulin binding cofactor C HlyD_3 PF13437.6 EEA05078.1 - 0.00017 22.2 0.4 0.00045 20.9 0.1 1.7 2 0 0 2 2 2 1 HlyD family secretion protein TPR_1 PF00515.28 EEA05079.1 - 6.3e-06 25.8 4.9 0.15 11.9 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA05079.1 - 1.1e-05 25.2 0.5 3 8.2 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA05079.1 - 4.4e-05 23.1 3.5 0.0037 16.9 0.1 3.4 2 1 1 3 3 3 1 TPR repeat TPR_19 PF14559.6 EEA05079.1 - 0.0043 17.5 0.1 0.013 16.0 0.0 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA05079.1 - 0.0062 16.7 1.7 0.92 9.8 0.1 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EEA05079.1 - 0.022 15.1 0.0 0.046 14.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ProQ PF04352.13 EEA05079.1 - 0.033 14.1 0.0 0.069 13.0 0.0 1.5 1 0 0 1 1 1 0 ProQ/FINO family NCKAP5 PF15246.6 EEA05080.1 - 0.059 13.0 0.5 0.14 11.7 0.5 1.6 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Rad51 PF08423.11 EEA05081.1 - 8.2e-119 395.5 0.1 1e-118 395.2 0.1 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EEA05081.1 - 2.9e-11 43.3 0.0 4.4e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EEA05081.1 - 1.1e-07 31.6 0.0 2.1e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EEA05081.1 - 4.2e-06 26.3 1.1 2.3e-05 23.8 1.1 2.2 1 1 0 1 1 1 1 KaiC DUF3853 PF12964.7 EEA05081.1 - 0.0018 18.4 0.1 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3853) HHH_5 PF14520.6 EEA05081.1 - 0.0037 17.8 0.0 0.014 16.0 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 EEA05081.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Paramecium_SA PF01508.16 EEA05081.1 - 0.37 11.3 3.8 0.8 10.2 0.6 2.3 2 0 0 2 2 2 0 Paramecium surface antigen domain PCI PF01399.27 EEA05082.1 - 0.0012 19.3 2.2 0.0029 18.1 0.2 2.8 3 0 0 3 3 3 1 PCI domain Mst1_SARAH PF11629.8 EEA05085.1 - 0.036 14.1 1.2 0.036 14.1 1.2 3.3 3 1 0 3 3 3 0 C terminal SARAH domain of Mst1 Glucodextran_C PF09985.9 EEA05085.1 - 0.1 12.0 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 C-terminal binding-module, SLH-like, of glucodextranase Allexi_40kDa PF05549.11 EEA05085.1 - 1.5 8.3 11.0 0.33 10.4 1.5 2.7 1 1 2 3 3 3 0 Allexivirus 40kDa protein HMG_box PF00505.19 EEA05086.1 - 4.1e-15 56.0 2.5 4.1e-15 56.0 2.5 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA05086.1 - 2.8e-10 40.6 2.6 4.8e-10 39.9 2.6 1.4 1 0 0 1 1 1 1 HMG-box domain GMC_oxred_C PF05199.13 EEA05087.1 - 2.9e-14 53.8 0.0 7.4e-12 46.0 0.0 2.5 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EEA05087.1 - 8.2e-10 38.5 0.1 2e-08 34.0 0.0 2.2 2 0 0 2 2 2 1 GMC oxidoreductase MMS1_N PF10433.9 EEA05088.1 - 8.1e-116 387.5 0.2 1.2e-115 387.0 0.2 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EEA05088.1 - 5.4e-75 252.7 1.3 2.4e-73 247.3 0.2 2.9 3 0 0 3 3 3 2 CPSF A subunit region adh_short PF00106.25 EEA05089.1 - 7e-26 90.9 0.5 4.4e-25 88.3 0.5 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA05089.1 - 6.1e-15 55.4 0.0 1.7e-14 54.0 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA05089.1 - 0.00016 21.6 0.0 0.00023 21.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA05089.1 - 0.0016 17.9 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Rad60-SLD PF11976.8 EEA05090.1 - 6.6e-20 70.7 0.0 8.3e-20 70.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EEA05090.1 - 1.2e-11 44.2 0.0 1.6e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UBX PF00789.20 EEA05090.1 - 0.043 14.0 0.0 0.054 13.7 0.0 1.3 1 0 0 1 1 1 0 UBX domain Ubiquitin_5 PF18037.1 EEA05090.1 - 0.057 13.8 0.0 0.08 13.3 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin-like domain PDZ_6 PF17820.1 EEA05090.1 - 0.083 12.8 0.1 0.31 10.9 0.1 1.9 2 0 0 2 2 2 0 PDZ domain Methyltransf_23 PF13489.6 EEA05091.1 - 1.4e-08 34.8 0.0 2.3e-08 34.1 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA05091.1 - 4.1e-06 27.5 0.1 4.7e-05 24.1 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA05091.1 - 5.1e-05 23.9 0.0 0.00048 20.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA05091.1 - 0.0069 17.0 0.2 0.18 12.4 0.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain Kri1_C PF12936.7 EEA05092.1 - 4.6e-23 81.2 2.8 4.6e-23 81.2 2.8 4.5 4 1 0 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 EEA05092.1 - 1e-13 51.7 10.4 1e-13 51.7 10.4 5.5 4 2 2 6 6 6 1 KRI1-like family ZZ PF00569.17 EEA05092.1 - 0.35 10.7 7.8 0.78 9.6 7.8 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type RNase_3_N PF18497.1 EEA05092.1 - 1.3 9.3 7.5 0.79 10.0 2.2 3.4 2 2 2 4 4 4 0 Ribonuclease III N-terminal domain PH PF00169.29 EEA05093.1 - 0.16 12.5 0.1 0.29 11.6 0.1 1.4 1 0 0 1 1 1 0 PH domain Fibrillarin PF01269.17 EEA05096.1 - 1.9e-104 347.7 0.0 2.3e-104 347.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EEA05096.1 - 0.00031 20.5 0.0 0.00046 19.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 EEA05096.1 - 0.031 14.4 0.0 0.059 13.5 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EEA05096.1 - 0.038 13.6 0.0 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F DREV PF05219.12 EEA05096.1 - 0.22 10.6 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase UCH PF00443.29 EEA05097.1 - 5.5e-47 160.4 2.3 5.5e-47 160.4 2.3 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA05097.1 - 6.6e-24 85.1 3.4 6.6e-24 85.1 3.4 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_L30 PF00327.20 EEA05098.1 - 6.1e-17 61.2 2.5 1.6e-16 59.9 2.5 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EEA05098.1 - 2.8e-10 40.3 9.6 5.5e-10 39.4 9.6 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_S8 PF00410.19 EEA05099.1 - 1.5e-20 73.4 0.0 2.3e-20 72.8 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Nop14 PF04147.12 EEA05100.1 - 8.6e-59 199.6 30.4 2.5e-52 178.3 24.4 2.4 2 1 0 2 2 2 2 Nop14-like family SKIP_SNW PF02731.15 EEA05101.1 - 3.7e-58 195.7 1.5 3.7e-58 195.7 1.5 2.1 2 0 0 2 2 2 1 SKIP/SNW domain Asp-B-Hydro_N PF05279.11 EEA05101.1 - 0.14 12.2 4.1 0.2 11.7 4.1 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4149 PF13664.6 EEA05102.1 - 3.9 7.9 13.4 7 7.0 13.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) Ac81 PF05820.11 EEA05102.1 - 5.2 6.6 5.4 8 6.0 5.4 1.2 1 0 0 1 1 1 0 Baculoviridae AC81 TFIIS_M PF07500.14 EEA05103.1 - 3.2e-25 88.8 1.4 1.6e-24 86.5 0.3 2.2 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EEA05103.1 - 1.7e-19 69.4 5.7 2.9e-19 68.6 5.7 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EEA05103.1 - 3.7e-06 26.8 0.9 1.1e-05 25.4 0.9 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zf-DNL PF05180.12 EEA05103.1 - 0.13 12.2 1.1 0.33 10.9 1.1 1.6 1 0 0 1 1 1 0 DNL zinc finger zinc_ribbon_4 PF13717.6 EEA05103.1 - 0.29 11.1 2.9 4.5 7.3 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_16 PF17034.5 EEA05105.1 - 2e-05 24.8 6.5 6.3e-05 23.2 6.5 2.0 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EEA05105.1 - 9.7e-05 21.9 12.7 0.00025 20.6 12.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EEA05105.1 - 0.0057 17.0 8.4 0.02 15.2 8.4 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA05105.1 - 0.028 14.3 8.3 0.067 13.1 8.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CARD PF00619.21 EEA05105.1 - 0.1 12.6 0.4 0.72 9.9 0.0 2.6 3 0 0 3 3 3 0 Caspase recruitment domain eIF-5_eIF-2B PF01873.17 EEA05106.1 - 1.7e-35 121.4 0.2 3.3e-35 120.5 0.0 1.5 2 0 0 2 2 2 1 Domain found in IF2B/IF5 Lar_restr_allev PF14354.6 EEA05106.1 - 0.011 16.1 0.1 0.024 15.0 0.1 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar TF_Zn_Ribbon PF08271.12 EEA05106.1 - 0.062 12.8 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding DUF678 PF05077.12 EEA05106.1 - 8.1 6.7 11.5 5.3 7.2 0.2 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF678) Acyl_transf_3 PF01757.22 EEA05107.1 - 1.4e-23 83.5 28.0 1.4e-23 83.5 28.0 2.3 2 0 0 2 2 2 1 Acyltransferase family Rcd1 PF04078.13 EEA05109.1 - 1.7e-116 388.0 0.6 2e-116 387.8 0.6 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Sec23_trunk PF04811.15 EEA05110.1 - 2.6e-58 197.5 0.0 4.8e-58 196.6 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EEA05110.1 - 2.9e-17 63.2 0.0 7.4e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EEA05110.1 - 2e-16 59.8 3.7 4.2e-16 58.7 3.7 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EEA05110.1 - 2.7e-15 56.0 0.6 1.2e-14 54.0 0.6 2.0 1 1 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EEA05110.1 - 7.2e-05 22.6 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EEA05110.1 - 0.006 16.0 0.1 0.015 14.7 0.1 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain PI3_PI4_kinase PF00454.27 EEA05113.1 - 3.8e-25 89.1 1.1 4e-18 66.1 0.5 3.0 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EEA05113.1 - 0.00036 20.0 1.4 0.0009 18.7 1.4 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF3341 PF11821.8 EEA05114.1 - 0.17 11.5 0.3 0.29 10.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) FAM184 PF15665.5 EEA05115.1 - 0.0012 18.6 6.4 0.0018 18.1 6.4 1.2 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B MSP1_C PF07462.11 EEA05115.1 - 0.0014 17.4 1.9 0.0016 17.2 1.9 1.0 1 0 0 1 1 1 1 Merozoite surface protein 1 (MSP1) C-terminus DUF4559 PF15112.6 EEA05115.1 - 0.029 14.1 4.2 0.03 14.0 4.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Baculo_PEP_C PF04513.12 EEA05115.1 - 0.041 13.9 0.3 0.055 13.5 0.3 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus THOC7 PF05615.13 EEA05115.1 - 0.052 13.8 6.9 0.092 13.0 6.7 1.5 1 1 0 1 1 1 0 Tho complex subunit 7 DUF2745 PF10922.8 EEA05115.1 - 0.075 13.3 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2745) Exonuc_VII_L PF02601.15 EEA05115.1 - 0.22 11.0 3.8 0.22 11.0 3.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 EEA05115.1 - 0.35 11.2 6.5 0.51 10.7 6.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Sof1 PF04158.14 EEA05117.1 - 8.4e-25 86.9 10.3 8.4e-25 86.9 10.3 1.7 2 0 0 2 2 2 1 Sof1-like domain WD40 PF00400.32 EEA05117.1 - 4.1e-18 65.4 14.1 0.00062 20.5 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat BBS2_Mid PF14783.6 EEA05117.1 - 0.00074 19.5 0.3 3.7 7.6 0.0 3.7 2 2 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EEA05117.1 - 0.0011 18.4 0.2 0.42 9.9 0.0 2.9 2 1 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 EEA05117.1 - 0.0028 17.9 0.0 0.36 11.1 0.0 3.5 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain KASH_CCD PF14662.6 EEA05118.1 - 2.5e-06 27.4 26.7 2.5e-06 27.4 26.7 3.4 2 1 1 3 3 3 1 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 EEA05118.1 - 1.2e-05 25.4 0.6 1.2e-05 25.4 0.6 5.8 4 1 1 5 5 5 1 Homeobox associated leucine zipper Latarcin PF10279.9 EEA05118.1 - 0.016 15.6 0.6 0.45 10.9 0.1 3.1 2 1 0 2 2 2 0 Latarcin precursor YabA PF06156.13 EEA05118.1 - 0.02 15.5 40.9 0.13 12.9 12.5 4.9 2 1 2 4 4 4 0 Initiation control protein YabA bZIP_1 PF00170.21 EEA05118.1 - 0.053 13.6 0.8 0.053 13.6 0.8 5.4 4 2 2 6 6 6 0 bZIP transcription factor PI3K_P85_iSH2 PF16454.5 EEA05118.1 - 0.071 12.7 0.2 0.071 12.7 0.2 4.2 3 1 1 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CALCOCO1 PF07888.11 EEA05118.1 - 1.8 7.3 32.5 0.37 9.6 26.9 2.2 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.15 EEA05118.1 - 2.3 8.6 39.0 47 4.3 35.1 3.2 2 1 0 2 2 2 0 Fez1 UPF0184 PF03670.13 EEA05118.1 - 3 8.3 17.1 3.3 8.2 1.9 4.7 3 1 2 5 5 5 0 Uncharacterised protein family (UPF0184) DUF4618 PF15397.6 EEA05118.1 - 6.9 6.0 45.8 0.97 8.8 0.1 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4618) GAS PF13851.6 EEA05118.1 - 9.4 5.5 53.8 0.95 8.8 24.7 3.3 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Lyase_8_N PF08124.11 EEA05119.1 - 0.18 10.7 5.8 0.022 13.7 0.8 1.8 1 1 1 2 2 2 0 Polysaccharide lyase family 8, N terminal alpha-helical domain CYTL1 PF15153.6 EEA05119.1 - 0.7 9.9 4.6 1.6 8.7 0.1 2.8 1 1 2 3 3 3 0 Cytokine-like protein 1 Rox3 PF08633.10 EEA05119.1 - 1.6 9.0 11.2 2.4 8.4 8.8 2.3 1 1 0 2 2 2 0 Rox3 mediator complex subunit DUF2053 PF09767.9 EEA05120.1 - 1.2e-07 32.0 7.6 1.2e-07 32.0 7.6 1.5 2 0 0 2 2 2 1 Predicted membrane protein (DUF2053) Peptidase_S78_2 PF14550.6 EEA05121.1 - 0.021 14.9 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative phage serine protease XkdF WBP-1 PF11669.8 EEA05121.1 - 0.052 14.2 1.6 1.3 9.7 0.1 2.9 2 0 0 2 2 2 0 WW domain-binding protein 1 Rad21_Rec8_N PF04825.13 EEA05122.1 - 5.6 7.2 8.5 1 9.5 0.3 3.8 4 0 0 4 4 4 0 N terminus of Rad21 / Rec8 like protein Dynactin_p22 PF07426.11 EEA05123.1 - 7.7e-05 22.6 0.5 7.7e-05 22.6 0.5 1.9 1 1 1 2 2 2 1 Dynactin subunit p22 bZIP_1 PF00170.21 EEA05124.1 - 6.9 6.9 9.0 0.63 10.2 1.2 3.0 3 0 0 3 3 3 0 bZIP transcription factor NUDIX PF00293.28 EEA05125.1 - 5.6e-09 36.1 0.0 8.7e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain SNF2_N PF00176.23 EEA05126.1 - 1.8e-50 171.7 0.0 4.6e-50 170.3 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain PHD PF00628.29 EEA05126.1 - 5.3e-20 71.1 67.2 4e-10 39.4 5.9 6.7 6 0 0 6 6 6 5 PHD-finger Helicase_C PF00271.31 EEA05126.1 - 4e-13 49.7 0.0 1.7e-12 47.6 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA05126.1 - 1e-05 25.6 0.3 5.4e-05 23.3 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PHD_2 PF13831.6 EEA05126.1 - 6.3e-05 22.4 0.7 6.3e-05 22.4 0.7 7.4 8 0 0 8 8 8 1 PHD-finger AAA_14 PF13173.6 EEA05126.1 - 0.28 11.2 1.4 1.2 9.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain ELO PF01151.18 EEA05127.1 - 3.7e-59 200.3 32.6 4.5e-59 200.0 32.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ANAPC4_WD40 PF12894.7 EEA05128.1 - 6.6e-08 32.7 0.1 0.026 14.8 0.0 4.7 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA05128.1 - 0.0004 21.1 6.4 25 5.9 0.0 6.5 6 2 1 7 7 7 1 WD domain, G-beta repeat DUF2139 PF09910.9 EEA05128.1 - 0.069 12.3 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2139) DNA_pol_delta_4 PF04081.13 EEA05129.1 - 1e-06 29.1 0.0 1.3e-06 28.8 0.0 1.3 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 LolA PF03548.15 EEA05129.1 - 0.038 13.7 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Hint PF01079.20 EEA05131.1 - 0.092 12.2 1.2 1.2 8.5 0.0 2.3 2 1 1 3 3 3 0 Hint module Brix PF04427.18 EEA05132.1 - 1.1e-19 71.4 0.0 1.8e-19 70.6 0.0 1.4 1 1 0 1 1 1 1 Brix domain Pkinase PF00069.25 EEA05134.1 - 1.2e-13 51.0 0.4 1.6e-13 50.7 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05134.1 - 1.2e-09 37.8 0.2 1.6e-09 37.4 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA05134.1 - 1.3e-08 34.4 0.0 1.8e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EEA05134.1 - 3.4e-08 33.3 0.0 5.1e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EEA05134.1 - 1.7e-06 28.1 0.0 0.021 14.7 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF1679 PF07914.11 EEA05134.1 - 0.0048 15.8 0.3 0.013 14.4 0.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EEA05134.1 - 0.0086 15.7 0.9 1.3 8.6 0.7 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase EcKinase PF02958.20 EEA05134.1 - 0.014 14.7 0.9 0.038 13.3 0.6 1.8 1 1 1 2 2 2 0 Ecdysteroid kinase DUF4528 PF15031.6 EEA05135.1 - 2.7 8.1 8.0 0.2 11.7 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4528) tRNA-synt_2b PF00587.25 EEA05136.1 - 9.4e-38 130.0 0.0 1.8e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EEA05136.1 - 4.5e-15 55.8 7.5 4.5e-15 55.8 7.5 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain TRAM_LAG1_CLN8 PF03798.16 EEA05137.1 - 3.9e-20 72.4 26.4 3.9e-20 72.4 26.4 1.7 2 0 0 2 2 2 1 TLC domain Adaptin_N PF01602.20 EEA05138.1 - 5.4e-89 299.1 9.5 1.8e-87 294.1 9.5 2.1 1 1 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EEA05138.1 - 2.5e-19 69.6 1.5 2.5e-19 69.6 1.5 2.4 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 EEA05138.1 - 0.00016 21.7 2.5 0.095 12.7 0.2 3.1 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Urb2 PF10441.9 EEA05138.1 - 0.031 14.2 3.1 0.32 10.9 0.4 2.9 2 1 0 2 2 2 0 Urb2/Npa2 family DEAD PF00270.29 EEA05139.1 - 3.7e-19 69.2 0.0 1.8e-18 66.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA05139.1 - 1.9e-13 50.8 7.9 9.2e-12 45.3 1.6 4.8 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA05139.1 - 1.9e-07 31.2 3.5 4.9e-07 29.9 0.1 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1998 PF09369.10 EEA05139.1 - 6.3e-05 23.7 0.4 0.00015 22.5 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) T4_Rnl2_C PF18043.1 EEA05139.1 - 0.0065 16.6 2.0 0.032 14.4 2.0 2.2 1 0 0 1 1 1 1 T4 RNA ligase 2 C-terminal GCFC PF07842.12 EEA05140.1 - 3.4e-05 23.6 1.4 3.4e-05 23.6 1.4 2.0 3 0 0 3 3 3 1 GC-rich sequence DNA-binding factor-like protein DCP1 PF06058.13 EEA05141.1 - 1.5e-37 128.1 1.0 3.4e-37 127.0 1.0 1.6 1 0 0 1 1 1 1 Dcp1-like decapping family BetaGal_dom3 PF13363.6 EEA05141.1 - 0.22 11.1 2.4 0.25 10.9 0.1 2.1 2 0 0 2 2 2 0 Beta-galactosidase, domain 3 ANAPC4_WD40 PF12894.7 EEA05142.1 - 0.024 14.9 0.1 0.14 12.5 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_11 PF17123.5 EEA05142.1 - 0.17 11.6 4.0 0.12 12.1 0.2 2.7 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA05142.1 - 1.4 8.9 5.7 2.5 8.0 0.1 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.29 EEA05143.1 - 0.00018 22.0 6.0 0.00044 20.7 0.6 3.2 3 0 0 3 3 3 1 PH domain EF-hand_7 PF13499.6 EEA05144.1 - 1.7e-18 66.8 4.4 3.9e-10 40.0 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA05144.1 - 2.4e-13 49.7 2.6 9.1e-08 31.8 0.0 4.1 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 EEA05144.1 - 9.2e-13 46.8 5.3 0.00046 19.5 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EEA05144.1 - 1.2e-11 43.6 7.8 0.0012 18.6 0.0 4.6 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EEA05144.1 - 2.6e-05 23.5 0.6 0.03 13.8 0.0 3.3 3 0 0 3 3 3 2 EF hand EFhand_Ca_insen PF08726.10 EEA05144.1 - 0.028 14.5 0.0 0.085 13.0 0.0 1.9 1 0 0 1 1 1 0 Ca2+ insensitive EF hand Ran_BP1 PF00638.18 EEA05147.1 - 2e-38 131.4 2.9 2e-38 131.4 2.9 1.5 2 0 0 2 2 2 1 RanBP1 domain WH1 PF00568.23 EEA05147.1 - 0.21 11.5 4.3 1.1 9.2 4.3 2.2 1 1 0 1 1 1 0 WH1 domain Hydrolase_4 PF12146.8 EEA05148.1 - 1.1e-18 67.4 0.0 9.2e-18 64.4 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA05148.1 - 2.4e-14 53.6 0.0 1e-10 41.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA05148.1 - 0.00011 22.8 0.0 0.00015 22.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EEA05148.1 - 0.0035 17.0 0.0 0.0048 16.5 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) LIDHydrolase PF10230.9 EEA05148.1 - 0.0063 16.1 0.1 0.01 15.4 0.1 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_2 PF02230.16 EEA05148.1 - 0.011 15.5 0.0 0.091 12.6 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 EEA05148.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.14 EEA05148.1 - 0.022 13.5 0.0 0.035 12.8 0.0 1.3 1 0 0 1 1 1 0 Ndr family Mpv17_PMP22 PF04117.12 EEA05149.1 - 2e-15 56.8 1.2 4.9e-15 55.5 1.2 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family zf-C3HC4_3 PF13920.6 EEA05150.1 - 7.4e-09 35.3 14.0 2.7e-08 33.5 14.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA05150.1 - 0.18 11.8 13.4 0.7 9.9 13.4 2.1 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA05150.1 - 0.47 10.5 8.7 1.8 8.6 8.7 2.1 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 EEA05150.1 - 3.5 7.6 15.7 3.1 7.7 13.6 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EEA05152.1 - 8.5e-07 28.7 16.5 1.8e-06 27.7 16.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA05152.1 - 0.28 11.1 16.5 0.79 9.7 16.5 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CWC25 PF12542.8 EEA05154.1 - 1.9e-05 25.5 0.6 0.00042 21.2 0.0 2.8 1 1 1 2 2 2 1 Pre-mRNA splicing factor Ins_P5_2-kin PF06090.12 EEA05155.1 - 1.3e-07 31.4 4.5 5.2e-07 29.4 4.5 1.8 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Csm1_N PF18504.1 EEA05156.1 - 1.4 9.3 5.8 24 5.4 0.6 3.1 2 0 0 2 2 2 0 Csm1 N-terminal domain Peptidase_U4 PF03419.13 EEA05157.1 - 0.0036 16.6 14.4 0.0049 16.2 14.4 1.1 1 0 0 1 1 1 1 Sporulation factor SpoIIGA zf-U1 PF06220.12 EEA05158.1 - 3e-17 62.1 1.8 3e-17 62.1 1.8 2.1 2 0 0 2 2 2 1 U1 zinc finger Herpes_MCP PF03122.14 EEA05158.1 - 0.0057 14.2 1.6 0.0067 14.0 1.6 1.0 1 0 0 1 1 1 1 Herpes virus major capsid protein Metallophos PF00149.28 EEA05159.1 - 4.9e-32 112.1 1.4 6.7e-32 111.6 1.0 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA05159.1 - 0.072 13.6 1.6 0.25 11.8 1.6 2.0 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain IMCp PF12314.8 EEA05160.1 - 4.4e-21 75.0 106.0 4.5e-10 39.7 36.6 6.3 1 1 5 6 6 6 4 Inner membrane complex protein Helicase_C PF00271.31 EEA05161.1 - 7.4e-14 52.0 1.6 9.5e-12 45.3 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EEA05161.1 - 2.1e-09 37.6 0.0 6.9e-09 36.0 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EEA05161.1 - 7.2e-07 29.5 0.0 7.2e-07 29.5 0.0 3.0 3 0 0 3 3 3 1 Helicase associated domain (HA2) DEAD PF00270.29 EEA05161.1 - 3.1e-05 23.8 0.6 0.00014 21.6 0.1 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA05161.1 - 0.0022 18.3 0.0 0.0067 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA05161.1 - 0.0063 16.7 0.6 0.018 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EEA05161.1 - 0.0066 15.5 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EEA05161.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA05161.1 - 0.085 13.2 0.0 0.27 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EEA05161.1 - 0.15 11.9 0.9 0.38 10.5 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain EF-hand_6 PF13405.6 EEA05163.1 - 2.7e-05 23.8 1.5 0.00016 21.3 0.1 2.8 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 EEA05163.1 - 3.2e-05 23.2 1.0 0.0033 16.9 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EEA05163.1 - 6.5e-05 23.3 0.9 0.00014 22.2 0.4 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EEA05163.1 - 0.063 13.1 0.4 18 5.2 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain pair DUF4064 PF13273.6 EEA05165.1 - 0.029 14.6 1.0 0.029 14.6 1.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) UBA_e1_thiolCys PF10585.9 EEA05165.1 - 0.054 13.4 1.6 0.077 12.9 1.6 1.2 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site Methyltrn_RNA_3 PF02598.17 EEA05166.1 - 0.14 11.7 0.2 0.22 11.0 0.2 1.2 1 0 0 1 1 1 0 Putative RNA methyltransferase ADIP PF11559.8 EEA05168.1 - 2.1e-06 27.9 6.9 2.6e-06 27.6 6.9 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Seryl_tRNA_N PF02403.22 EEA05168.1 - 7.5e-05 22.9 3.3 0.0001 22.5 3.3 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 EEA05168.1 - 0.00019 20.7 5.2 0.00021 20.5 5.2 1.0 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 EEA05168.1 - 0.0012 17.8 5.2 0.0013 17.6 5.2 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF4686 PF15742.5 EEA05168.1 - 0.0019 17.4 7.3 0.002 17.3 7.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) CREPT PF16566.5 EEA05168.1 - 0.0021 18.2 8.0 0.0033 17.6 7.6 1.5 1 1 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour DUF3584 PF12128.8 EEA05168.1 - 0.003 15.2 4.4 0.0035 14.9 4.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Fib_alpha PF08702.10 EEA05168.1 - 0.0043 17.2 5.4 0.0052 17.0 5.4 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family TMPIT PF07851.13 EEA05168.1 - 0.0072 15.6 2.2 0.0084 15.4 2.2 1.0 1 0 0 1 1 1 1 TMPIT-like protein HALZ PF02183.18 EEA05168.1 - 0.0074 16.5 3.5 0.0074 16.5 3.5 2.2 2 0 0 2 2 2 1 Homeobox associated leucine zipper Exo84_C PF16528.5 EEA05168.1 - 0.0078 16.1 3.2 0.0096 15.8 3.2 1.1 1 0 0 1 1 1 1 Exocyst component 84 C-terminal TACC_C PF05010.14 EEA05168.1 - 0.0088 15.8 5.5 0.014 15.2 5.5 1.3 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DHR10 PF18595.1 EEA05168.1 - 0.011 15.8 5.3 0.015 15.3 5.3 1.2 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain ATG16 PF08614.11 EEA05168.1 - 0.011 15.9 6.1 0.013 15.7 6.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) OmpH PF03938.14 EEA05168.1 - 0.012 15.9 2.5 0.014 15.7 2.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ENTH PF01417.20 EEA05168.1 - 0.016 15.3 0.9 0.019 15.0 0.9 1.2 1 0 0 1 1 1 0 ENTH domain GAS PF13851.6 EEA05168.1 - 0.017 14.5 8.5 0.023 14.1 8.5 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2347 PF09804.9 EEA05168.1 - 0.021 14.4 0.9 0.023 14.3 0.9 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) AP-5_subunit_s1 PF15001.6 EEA05168.1 - 0.022 14.8 0.7 0.03 14.3 0.7 1.3 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 TSNAXIP1_N PF15739.5 EEA05168.1 - 0.025 14.9 4.2 0.036 14.4 4.2 1.4 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus Prominin PF05478.11 EEA05168.1 - 0.026 12.5 2.5 0.028 12.4 2.5 1.1 1 0 0 1 1 1 0 Prominin Prefoldin_2 PF01920.20 EEA05168.1 - 0.026 14.5 9.2 0.49 10.4 2.5 2.3 1 1 1 2 2 2 0 Prefoldin subunit DASH_Dam1 PF08653.10 EEA05168.1 - 0.032 14.0 1.4 0.38 10.6 0.1 2.5 1 1 1 2 2 2 0 DASH complex subunit Dam1 DUF5344 PF17279.2 EEA05168.1 - 0.034 14.7 3.6 0.12 12.9 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF2524 PF10732.9 EEA05168.1 - 0.036 14.4 3.2 0.24 11.7 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) FRB_dom PF08771.11 EEA05168.1 - 0.04 14.3 0.4 0.054 13.9 0.4 1.1 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain Wtap PF17098.5 EEA05168.1 - 0.044 13.7 4.4 0.12 12.3 0.8 2.1 1 1 1 2 2 2 0 WTAP/Mum2p family KxDL PF10241.9 EEA05168.1 - 0.044 14.0 4.7 0.066 13.5 4.5 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein DUF641 PF04859.12 EEA05168.1 - 0.045 14.1 3.7 0.067 13.5 3.7 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) APG6_N PF17675.1 EEA05168.1 - 0.054 14.0 7.6 0.068 13.7 7.6 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DASH_Dad2 PF08654.10 EEA05168.1 - 0.054 13.9 3.7 0.39 11.2 3.5 1.9 1 1 1 2 2 2 0 DASH complex subunit Dad2 ZapB PF06005.12 EEA05168.1 - 0.059 13.8 8.9 0.078 13.4 1.7 2.1 1 1 1 2 2 2 0 Cell division protein ZapB Swi5 PF07061.11 EEA05168.1 - 0.062 13.4 7.1 0.55 10.4 1.5 2.2 1 1 1 2 2 2 0 Swi5 DUF1664 PF07889.12 EEA05168.1 - 0.064 13.3 3.0 0.11 12.6 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 EEA05168.1 - 0.065 13.5 6.6 0.085 13.1 6.6 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 EEA05168.1 - 0.075 12.8 1.9 0.088 12.6 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4795 PF16043.5 EEA05168.1 - 0.081 12.5 6.8 0.14 11.7 6.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Nup88 PF10168.9 EEA05168.1 - 0.089 10.6 6.9 0.096 10.5 6.9 1.0 1 0 0 1 1 1 0 Nuclear pore component UPF0515 PF15135.6 EEA05168.1 - 0.089 12.1 1.2 0.098 12.0 1.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 DUF948 PF06103.11 EEA05168.1 - 0.11 12.8 2.1 0.15 12.3 2.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Med9 PF07544.13 EEA05168.1 - 0.12 12.5 5.3 1.1 9.4 5.3 2.1 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF3810 PF12725.7 EEA05168.1 - 0.13 11.6 1.1 0.15 11.3 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Nup54 PF13874.6 EEA05168.1 - 0.14 12.3 3.1 0.14 12.2 3.1 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 FapA PF03961.13 EEA05168.1 - 0.14 10.7 2.5 0.16 10.5 2.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4349 PF14257.6 EEA05168.1 - 0.17 11.3 3.8 0.81 9.1 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) V_ATPase_I PF01496.19 EEA05168.1 - 0.18 9.7 4.5 0.19 9.6 4.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tektin PF03148.14 EEA05168.1 - 0.21 10.3 10.2 0.61 8.8 8.0 2.0 1 1 1 2 2 2 0 Tektin family DUF4446 PF14584.6 EEA05168.1 - 0.25 11.3 2.7 0.31 11.0 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) YabA PF06156.13 EEA05168.1 - 0.25 12.0 5.0 1 10.0 0.8 2.0 1 1 1 2 2 2 0 Initiation control protein YabA FliD_N PF02465.18 EEA05168.1 - 0.37 11.5 5.8 6.8 7.5 0.4 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3450 PF11932.8 EEA05168.1 - 0.42 9.9 6.6 0.81 8.9 6.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) GIT_CC PF16559.5 EEA05168.1 - 0.44 10.5 6.3 0.36 10.7 3.9 1.9 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4140 PF13600.6 EEA05168.1 - 0.49 10.9 3.9 38 4.8 3.9 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Streptin-Immun PF11083.8 EEA05168.1 - 0.56 10.7 7.2 6.4 7.2 1.9 2.2 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein DUF2205 PF10224.9 EEA05168.1 - 1.1 9.3 7.7 20 5.2 7.7 2.1 1 1 0 1 1 1 0 Short coiled-coil protein DivIC PF04977.15 EEA05168.1 - 2 8.2 9.4 2.6 7.9 1.4 2.2 1 1 1 2 2 2 0 Septum formation initiator Ribosomal_L7Ae PF01248.26 EEA05170.1 - 6.2e-19 67.5 0.1 1e-18 66.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Peptidase_C48 PF02902.19 EEA05171.1 - 4.5e-19 69.1 7.2 6.3e-19 68.7 7.2 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Vhr1 PF04001.13 EEA05171.1 - 0.091 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Transcription factor Vhr1 PH_15 PF17339.2 EEA05171.1 - 0.32 10.9 2.6 0.8 9.6 0.8 2.2 2 0 0 2 2 2 0 PH domain KH_6 PF15985.5 EEA05172.1 - 3.8e-10 39.9 0.2 4.9e-08 33.2 0.0 2.7 2 0 0 2 2 2 2 KH domain UPF0086 PF01868.16 EEA05174.1 - 4.5e-23 81.0 0.0 9.1e-23 80.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function UPF0086 AI-2E_transport PF01594.16 EEA05176.1 - 0.045 12.9 5.3 0.23 10.6 5.5 1.8 1 1 0 1 1 1 0 AI-2E family transporter DUF2367 PF10164.9 EEA05176.1 - 2.1 8.9 12.2 3.7 8.1 12.2 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Ribosomal_L29 PF00831.23 EEA05178.1 - 1.6e-17 63.2 3.0 1.6e-17 63.2 3.0 1.7 2 1 0 2 2 2 1 Ribosomal L29 protein HLH PF00010.26 EEA05178.1 - 0.0073 16.2 0.4 0.02 14.9 0.4 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Phage_min_cap2 PF06152.11 EEA05178.1 - 0.02 13.8 0.9 0.023 13.6 0.9 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 Herpes_BLRF2 PF05812.12 EEA05178.1 - 1.6 8.9 8.4 3 8.0 2.2 2.1 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein SWIB PF02201.18 EEA05179.1 - 2.5e-14 52.9 0.3 7.3e-14 51.4 0.3 1.9 1 0 0 1 1 1 1 SWIB/MDM2 domain tify PF06200.14 EEA05179.1 - 0.097 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 tify domain Peptidase_M3_N PF08439.10 EEA05179.1 - 0.12 12.7 0.7 0.44 10.9 0.7 1.9 1 0 0 1 1 1 0 Oligopeptidase F GshA PF08886.11 EEA05180.1 - 0.012 14.2 0.5 0.016 13.8 0.5 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase PLATZ PF04640.14 EEA05180.1 - 0.12 13.0 1.2 0.22 12.1 1.2 1.4 1 0 0 1 1 1 0 PLATZ transcription factor Arf PF00025.21 EEA05181.1 - 5.9e-79 263.6 0.1 6.7e-79 263.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA05181.1 - 4.8e-14 52.6 0.0 7e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EEA05181.1 - 8.6e-14 51.4 0.0 1e-13 51.1 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EEA05181.1 - 5.6e-13 48.8 0.0 6.5e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EEA05181.1 - 3.8e-12 46.0 0.5 5.7e-08 32.3 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EEA05181.1 - 2.2e-10 40.3 0.0 2.8e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA05181.1 - 5e-06 26.6 0.0 7.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA05181.1 - 0.0078 15.8 0.1 0.022 14.3 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.18 EEA05181.1 - 0.0084 15.4 0.1 0.012 15.0 0.1 1.4 1 1 0 1 1 1 1 6-phosphofructo-2-kinase RsgA_GTPase PF03193.16 EEA05181.1 - 0.013 15.4 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 EEA05181.1 - 0.09 12.9 0.6 0.41 10.8 0.6 2.0 1 1 0 1 1 1 0 AAA domain Flavoprotein PF02441.19 EEA05182.1 - 1.6e-47 161.2 0.2 1.8e-47 161.0 0.2 1.0 1 0 0 1 1 1 1 Flavoprotein FtsJ PF01728.19 EEA05184.1 - 1.7e-67 227.0 0.0 2e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Rad60-SLD PF11976.8 EEA05185.1 - 0.00031 20.5 3.4 0.00036 20.3 0.3 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like HHV6-IE PF03753.13 EEA05185.1 - 0.018 12.5 5.5 0.024 12.1 5.5 1.1 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein Rad10 PF03834.14 EEA05186.1 - 0.00032 20.7 0.3 0.0006 19.8 0.3 1.5 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) DUF4856 PF16148.5 EEA05186.1 - 0.076 12.0 0.2 0.32 10.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4856) Pkinase PF00069.25 EEA05187.1 - 5.2e-80 268.6 1.7 8.7e-80 267.9 0.2 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05187.1 - 2.6e-42 144.9 0.0 4.5e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EEA05187.1 - 2.1e-25 86.3 11.2 2.3e-07 29.9 0.6 4.8 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA05187.1 - 3e-23 82.1 8.5 2.3e-13 50.4 3.1 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA05187.1 - 3.9e-19 67.2 11.6 6.1e-06 25.5 0.1 5.1 4 1 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 EEA05187.1 - 8.8e-18 62.7 13.5 3.9e-06 26.3 0.5 5.4 3 1 2 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EEA05187.1 - 8.5e-17 60.8 8.6 0.0012 18.7 0.0 5.0 3 1 2 5 5 5 4 EF-hand domain pair Kdo PF06293.14 EEA05187.1 - 1.1e-06 28.2 0.1 3.3e-06 26.6 0.1 1.9 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA05187.1 - 3.9e-06 25.9 0.0 9.1e-06 24.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase EF-hand_4 PF12763.7 EEA05187.1 - 1.1e-05 25.3 5.7 0.28 11.1 0.6 4.2 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Kinase-like PF14531.6 EEA05187.1 - 3.1e-05 23.5 0.0 0.0071 15.7 0.0 2.7 1 1 1 2 2 2 1 Kinase-like SPARC_Ca_bdg PF10591.9 EEA05187.1 - 0.00012 22.3 2.5 0.6 10.4 0.1 3.1 1 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region APH PF01636.23 EEA05187.1 - 0.00092 19.2 0.0 0.0071 16.3 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EEA05187.1 - 0.07 12.8 1.8 15 5.1 0.0 3.1 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Glycos_trans_3N PF02885.17 EEA05187.1 - 0.077 12.9 0.2 6.9 6.6 0.0 2.9 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain YrbL-PhoP_reg PF10707.9 EEA05187.1 - 0.11 12.0 2.0 0.17 11.4 0.1 2.2 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Caleosin PF05042.13 EEA05187.1 - 0.39 10.6 1.9 2.9 7.8 0.2 2.8 2 1 1 3 3 3 0 Caleosin related protein ubiquitin PF00240.23 EEA05188.1 - 0.014 15.1 0.1 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin family DnaJ PF00226.31 EEA05189.1 - 1.6e-13 50.6 1.5 7.6e-12 45.2 1.5 2.3 1 1 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 EEA05189.1 - 5.9e-08 32.3 0.9 1.1e-07 31.4 0.9 1.5 1 0 0 1 1 1 1 CSL zinc finger Alginate_exp PF13372.6 EEA05190.1 - 0.18 10.5 0.0 0.46 9.2 0.0 1.6 2 0 0 2 2 2 0 Alginate export DUF1043 PF06295.12 EEA05190.1 - 0.2 11.7 0.3 0.2 11.7 0.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1043) APG6_N PF17675.1 EEA05190.1 - 0.2 12.2 9.3 0.66 10.5 9.3 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Tup_N PF08581.10 EEA05190.1 - 0.29 11.4 11.0 0.066 13.5 4.7 2.9 2 1 2 4 4 4 0 Tup N-terminal CNDH2_C PF16858.5 EEA05191.1 - 2.7e-30 106.2 0.7 6.9e-30 104.9 0.7 1.7 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.11 EEA05191.1 - 8.3e-24 84.0 1.5 6.3e-23 81.1 1.5 2.6 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal PRIMA1 PF16101.5 EEA05192.1 - 0.0012 18.9 0.1 0.0026 17.8 0.0 1.6 2 0 0 2 2 2 1 Proline-rich membrane anchor 1 Cadherin_C_2 PF16492.5 EEA05192.1 - 0.08 13.7 0.9 0.19 12.5 0.3 2.0 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal PrgI PF12666.7 EEA05193.1 - 0.066 13.9 0.1 4.3 8.1 0.0 2.2 2 0 0 2 2 2 0 PrgI family protein DUF5305 PF17231.2 EEA05193.1 - 0.067 12.6 0.0 0.091 12.1 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) UPF0767 PF15990.5 EEA05193.1 - 0.069 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 UPF0767 family CitMHS PF03600.16 EEA05193.1 - 0.073 12.3 0.0 0.079 12.1 0.0 1.0 1 0 0 1 1 1 0 Citrate transporter Rhomboid PF01694.22 EEA05194.1 - 4.3e-28 98.2 11.7 4.3e-28 98.2 11.7 2.0 3 0 0 3 3 3 1 Rhomboid family DER1 PF04511.15 EEA05194.1 - 5.9e-05 23.1 2.4 0.00012 22.0 2.4 1.6 1 1 0 1 1 1 1 Der1-like family Aminotran_5 PF00266.19 EEA05197.1 - 5.9e-25 88.0 0.0 1.1e-15 57.4 0.0 3.2 3 0 0 3 3 3 3 Aminotransferase class-V ATP_bind_3 PF01171.20 EEA05197.1 - 1.3e-15 57.7 0.0 2.9e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 EEA05197.1 - 0.0016 17.6 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 NAD synthase DUF4187 PF13821.6 EEA05197.1 - 0.23 11.3 4.1 3.2 7.6 0.6 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4187) zf-C2H2_4 PF13894.6 EEA05197.1 - 0.46 11.5 6.5 0.11 13.4 1.6 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA05197.1 - 1.2 9.5 7.4 0.43 10.9 2.5 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding C1_2 PF03107.16 EEA05197.1 - 7.1 7.0 9.6 6.3 7.2 0.6 2.9 2 0 0 2 2 2 0 C1 domain TPR_2 PF07719.17 EEA05198.1 - 0.0011 19.0 0.0 1.5 9.1 0.6 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA05198.1 - 0.038 14.3 0.2 17 5.8 0.3 2.7 2 1 0 3 3 3 0 Tetratricopeptide repeat T4_Gp59_C PF08994.10 EEA05198.1 - 0.039 14.6 1.4 3.5 8.3 0.0 2.6 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase C-term zf-Tim10_DDP PF02953.15 EEA05199.1 - 4.9e-16 58.1 0.0 5.8e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Vps39_2 PF10367.9 EEA05200.1 - 3.9e-20 72.3 3.8 9.9e-20 71.0 0.1 3.2 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EEA05200.1 - 0.00029 20.5 1.7 0.00056 19.6 0.5 2.1 2 0 0 2 2 2 1 CNH domain Ribosomal_S4e PF00900.20 EEA05200.1 - 0.083 12.8 0.0 0.27 11.2 0.0 1.9 1 0 0 1 1 1 0 Ribosomal family S4e zf-C2H2_jaz PF12171.8 EEA05201.1 - 0.00017 21.8 3.4 0.0004 20.6 3.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.12 EEA05201.1 - 0.00069 19.9 0.9 0.0013 19.0 0.9 1.4 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 EEA05201.1 - 0.0063 16.8 0.3 0.01 16.1 0.3 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Cor1 PF04803.12 EEA05201.1 - 0.013 15.7 4.2 0.026 14.7 4.2 1.4 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region DUF3449 PF11931.8 EEA05201.1 - 0.06 13.1 2.3 0.068 13.0 1.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3449) Cortex-I_coil PF09304.10 EEA05201.1 - 0.076 13.2 4.4 0.27 11.5 2.0 2.1 2 0 0 2 2 2 0 Cortexillin I, coiled coil Synaptobrevin PF00957.21 EEA05202.1 - 2.4e-21 75.3 1.6 5.8e-21 74.1 1.6 1.7 1 0 0 1 1 1 1 Synaptobrevin LapA_dom PF06305.11 EEA05202.1 - 0.0065 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain TMEM100 PF16311.5 EEA05202.1 - 0.15 11.6 1.1 0.31 10.6 1.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 WD40 PF00400.32 EEA05203.1 - 2.9e-24 84.9 18.8 9.7e-05 23.1 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 EEA05203.1 - 9.6e-05 21.2 3.1 0.09 11.4 0.2 3.5 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EEA05203.1 - 0.029 13.7 4.8 0.099 11.9 2.6 2.6 1 1 1 2 2 2 0 WD40-like domain Nucleoporin_N PF08801.11 EEA05203.1 - 0.081 11.7 6.8 0.96 8.1 0.9 3.2 1 1 2 4 4 4 0 Nup133 N terminal like ANAPC4_WD40 PF12894.7 EEA05203.1 - 0.1 12.9 0.1 2.9 8.3 0.0 2.8 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C71 PF12386.8 EEA05204.1 - 0.069 12.8 2.2 3.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Pseudomurein endo-isopeptidase Pei Guanylate_cyc PF00211.20 EEA05205.1 - 6.4e-71 237.8 2.1 1.1e-35 122.9 0.2 4.3 3 1 0 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain PhoLip_ATPase_C PF16212.5 EEA05205.1 - 5.3e-28 98.4 28.9 5.3e-28 98.4 28.9 5.1 4 1 1 5 5 5 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA05205.1 - 4.7e-05 23.0 1.1 0.00065 19.3 0.2 3.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EEA05205.1 - 0.0053 16.3 0.5 0.027 14.0 0.0 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Myb_DNA-binding PF00249.31 EEA05206.1 - 2.5e-45 152.4 8.9 1.2e-09 38.2 0.0 6.3 6 0 0 6 6 6 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA05206.1 - 6.8e-38 128.7 19.3 1.8e-11 44.1 1.1 6.7 2 1 4 6 6 6 5 Myb-like DNA-binding domain SLIDE PF09111.10 EEA05206.1 - 5e-05 23.3 0.1 5.3 7.1 0.0 4.4 2 1 2 4 4 4 3 SLIDE FlxA PF14282.6 EEA05207.1 - 0.029 14.4 2.2 0.029 14.4 2.2 2.0 2 0 0 2 2 2 0 FlxA-like protein LRS4 PF10422.9 EEA05207.1 - 0.21 11.1 8.4 0.3 10.6 8.4 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF1512 PF07431.12 EEA05207.1 - 1.8 7.5 6.6 1.3 7.9 5.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1512) HECT PF00632.25 EEA05208.1 - 4.6e-94 315.3 2.1 5.3e-94 315.2 0.1 2.2 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF913 PF06025.12 EEA05208.1 - 6.1e-13 48.5 16.2 9.2e-13 47.9 4.8 4.3 2 1 0 2 2 2 1 Domain of Unknown Function (DUF913) UBM PF14377.6 EEA05208.1 - 7.8e-09 34.7 9.3 0.00049 19.5 0.6 4.0 3 1 0 3 3 3 3 Ubiquitin binding region Prefoldin_2 PF01920.20 EEA05209.1 - 1.2e-15 57.3 14.2 1.4e-15 57.2 14.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EEA05209.1 - 0.0011 18.8 8.3 0.0058 16.5 8.3 1.8 1 1 0 1 1 1 1 Prefoldin subunit H-kinase_dim PF02895.14 EEA05209.1 - 0.092 13.1 3.1 0.34 11.3 3.1 1.9 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain DUF1664 PF07889.12 EEA05209.1 - 0.19 11.8 7.7 0.074 13.1 4.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EEA05209.1 - 0.36 11.0 10.3 0.56 10.4 3.2 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 EEA05209.1 - 0.43 10.9 8.8 0.058 13.7 2.9 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF148 PF02520.17 EEA05209.1 - 0.5 10.5 10.8 1.3 9.2 10.6 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF148 Spc24 PF08286.11 EEA05209.1 - 0.94 9.8 9.6 2.9 8.2 2.8 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 SlyX PF04102.12 EEA05209.1 - 1.7 9.3 5.7 23 5.7 0.2 2.5 2 1 0 2 2 2 0 SlyX DUF21 PF01595.20 EEA05210.1 - 1.4e-35 122.6 0.6 2.9e-35 121.5 0.6 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain HABP4_PAI-RBP1 PF04774.15 EEA05211.1 - 7.9e-10 39.6 0.6 7.9e-10 39.6 0.6 2.6 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family HTH_50 PF18024.1 EEA05211.1 - 0.13 11.9 0.3 2.4 7.9 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain zf-CCCH_2 PF14608.6 EEA05212.1 - 2e-13 50.3 32.3 1.3e-05 25.4 2.9 3.7 4 0 0 4 4 4 3 RNA-binding, Nab2-type zinc finger PWI PF01480.17 EEA05212.1 - 2.1e-05 24.8 0.1 4.7e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 PWI domain Nab2p_Zf1 PF18260.1 EEA05212.1 - 0.0075 16.1 6.3 0.11 12.4 2.8 2.4 2 0 0 2 2 2 2 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 MRG PF05712.13 EEA05212.1 - 0.036 13.4 0.3 0.049 12.9 0.3 1.2 1 0 0 1 1 1 0 MRG Ribosomal_L14e PF01929.17 EEA05214.1 - 2.5e-22 79.1 1.5 3.6e-22 78.6 1.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EEA05214.1 - 0.044 13.7 0.0 3.3 7.8 0.0 2.3 2 0 0 2 2 2 0 KOW motif zf-C3HC4_3 PF13920.6 EEA05215.1 - 2.9e-13 49.4 13.9 6.5e-13 48.3 13.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA05215.1 - 2.1e-06 27.9 12.8 5e-06 26.8 12.8 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EEA05215.1 - 5.9e-05 22.9 14.8 5.9e-05 22.9 14.8 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA05215.1 - 0.00042 20.2 11.5 0.00095 19.1 11.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA05215.1 - 0.066 13.1 13.2 0.16 11.8 13.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EF-hand_1 PF00036.32 EEA05216.1 - 1.9e-21 73.9 10.6 4.1e-09 35.3 1.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EEA05216.1 - 3.2e-18 64.1 6.5 5.9e-06 25.8 0.4 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EEA05216.1 - 2.1e-17 63.3 7.9 2.3e-13 50.4 2.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA05216.1 - 1.1e-14 54.0 8.7 7.4e-13 48.1 0.7 2.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 EEA05216.1 - 8.8e-10 38.8 0.3 6.7e-07 29.5 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EEA05216.1 - 2.3e-07 30.0 8.6 0.00039 19.8 1.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_14 PF17959.1 EEA05216.1 - 0.0053 17.1 1.4 0.085 13.2 1.4 2.2 1 1 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 EEA05216.1 - 0.012 15.6 3.0 0.048 13.6 0.7 2.3 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Arena_ncap_C PF17290.2 EEA05216.1 - 0.022 14.1 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain SUB1_ProdP9 PF18213.1 EEA05216.1 - 0.026 14.3 1.0 0.57 10.1 0.4 2.1 1 1 0 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF2529 PF10740.9 EEA05217.1 - 0.017 14.7 1.5 0.034 13.8 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2529) Chordopox_A15 PF05846.12 EEA05217.1 - 0.15 12.3 2.8 12 6.2 0.0 3.0 2 0 0 2 2 2 0 Chordopoxvirus A15 protein 14-3-3 PF00244.20 EEA05218.1 - 1.4e-98 328.9 6.9 1.6e-98 328.7 6.9 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 EEA05218.1 - 0.0012 19.0 1.1 0.012 15.9 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA05218.1 - 0.0069 17.1 3.0 16 6.7 0.1 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat dsrm PF00035.26 EEA05218.1 - 0.034 14.8 0.0 0.073 13.8 0.0 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding motif DASH_Dad4 PF08650.10 EEA05218.1 - 0.074 13.0 2.3 0.16 11.9 0.0 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad4 PGI PF00342.19 EEA05218.1 - 0.11 11.0 0.1 0.16 10.5 0.1 1.2 1 0 0 1 1 1 0 Phosphoglucose isomerase DUF3560 PF12083.8 EEA05218.1 - 1.6 8.9 8.4 3.9 7.6 0.0 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3560) YkyA PF10368.9 EEA05218.1 - 7.6 6.2 13.7 2.6 7.7 0.1 2.8 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein CREPT PF16566.5 EEA05218.1 - 9.6 6.4 7.9 3.3 7.9 0.2 2.7 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Ribosomal_L11_N PF03946.14 EEA05219.1 - 1.2e-19 69.9 0.1 2e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EEA05219.1 - 2.5e-16 59.9 0.1 4.1e-16 59.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain ZYG-11_interact PF05884.12 EEA05219.1 - 0.12 11.8 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 UBA_4 PF14555.6 EEA05220.1 - 6.6e-14 51.5 0.5 1.3e-13 50.5 0.5 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EEA05220.1 - 8.6e-11 41.9 0.0 2.8e-10 40.2 0.0 1.9 1 1 0 1 1 1 1 UBX domain TAP_C PF03943.13 EEA05220.1 - 0.00023 20.7 0.2 0.00045 19.8 0.2 1.5 1 0 0 1 1 1 1 TAP C-terminal domain RLL PF10036.9 EEA05220.1 - 0.0085 16.0 2.7 0.0085 16.0 2.7 1.7 1 1 1 2 2 2 1 RNA transcription, translation and transport factor protein UPF0052 PF01933.18 EEA05220.1 - 0.1 11.8 0.8 0.22 10.7 0.8 1.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0052 TAFII28 PF04719.14 EEA05221.1 - 0.0015 18.6 0.1 0.0041 17.2 0.1 1.7 1 0 0 1 1 1 1 hTAFII28-like protein conserved region DUF443 PF04276.12 EEA05221.1 - 0.0071 16.2 4.0 0.01 15.6 4.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF443) DUF5436 PF17504.2 EEA05222.1 - 1.3 9.4 3.7 3 8.2 3.7 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5436) NMD3 PF04981.13 EEA05223.1 - 4.9e-76 255.4 9.4 8.1e-76 254.7 9.4 1.4 1 0 0 1 1 1 1 NMD3 family ubiquitin PF00240.23 EEA05224.1 - 9.8e-15 54.1 0.0 2.4e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EEA05224.1 - 0.0086 16.6 0.3 0.073 13.6 0.3 2.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.6 EEA05224.1 - 0.0095 16.4 0.0 0.047 14.1 0.0 2.2 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 EEA05224.1 - 0.01 15.6 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Methyltransf_11 PF08241.12 EEA05225.1 - 2.1e-08 34.7 0.0 3.4e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA05225.1 - 8e-08 32.9 0.0 2.4e-07 31.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA05225.1 - 0.00097 19.0 0.1 0.0012 18.7 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA05225.1 - 0.013 15.1 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain AKNA PF12443.8 EEA05226.1 - 0.013 16.1 0.1 0.021 15.4 0.1 1.3 1 1 0 1 1 1 0 AT-hook-containing transcription factor DUF5344 PF17279.2 EEA05226.1 - 0.03 14.9 2.3 2.3 8.8 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5344) IQ PF00612.27 EEA05227.1 - 4e-08 32.4 2.2 0.0085 15.8 0.0 3.6 3 0 0 3 3 3 2 IQ calmodulin-binding motif AMPK1_CBM PF16561.5 EEA05227.1 - 3.2e-05 24.1 1.8 3.5e-05 24.0 0.1 2.0 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase IQ PF00612.27 EEA05228.1 - 6e-11 41.1 8.4 0.00024 20.6 0.8 3.7 3 0 0 3 3 3 3 IQ calmodulin-binding motif GLYCAM-1 PF05242.11 EEA05228.1 - 0.047 13.8 3.0 0.15 12.2 3.0 1.8 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Tox-REase-7 PF15649.6 EEA05229.1 - 0.082 13.2 0.4 0.17 12.2 0.4 1.6 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 Caskin-tail PF16632.5 EEA05229.1 - 0.45 11.0 3.4 0.93 10.0 0.4 2.6 1 1 2 3 3 3 0 C-terminal region of Caskin DUF1500 PF07389.12 EEA05230.1 - 0.0045 17.0 1.1 3 8.0 0.0 3.7 3 0 0 3 3 3 2 Protein of unknown function (DUF1500) PFK PF00365.20 EEA05231.1 - 3e-51 174.4 0.9 6e-35 120.9 0.3 3.1 2 1 0 2 2 2 2 Phosphofructokinase DUF1242 PF06842.12 EEA05232.1 - 2.3e-14 52.9 1.7 3.5e-14 52.3 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Jag_N PF14804.6 EEA05232.1 - 0.15 12.4 0.2 0.2 12.0 0.2 1.2 1 0 0 1 1 1 0 Jag N-terminus SAP PF02037.27 EEA05233.1 - 1e-13 50.7 0.8 2.4e-13 49.5 0.8 1.7 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 EEA05233.1 - 0.0014 18.4 15.1 0.023 14.5 0.1 3.8 2 1 2 4 4 4 3 Tho1/MOS11 C-terminal domain Band_7 PF01145.25 EEA05234.1 - 7.5e-26 91.2 0.2 1.2e-25 90.6 0.2 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EEA05234.1 - 3.6e-16 59.0 0.2 7.9e-16 57.9 0.2 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.6 EEA05234.1 - 0.044 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 SPFH domain-Band 7 family zf-U1 PF06220.12 EEA05235.1 - 4.6e-07 29.5 1.4 8.1e-07 28.7 1.4 1.4 1 0 0 1 1 1 1 U1 zinc finger IMS PF00817.20 EEA05235.1 - 0.0062 16.5 0.1 0.0084 16.1 0.1 1.2 1 0 0 1 1 1 1 impB/mucB/samB family Rep_fac_C PF08542.11 EEA05236.1 - 6.1e-16 58.6 0.1 2.3e-15 56.8 0.0 2.0 2 1 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 EEA05236.1 - 7.4e-16 58.8 0.0 1.3e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EEA05236.1 - 5.2e-12 45.9 0.1 3.3e-10 40.0 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EEA05236.1 - 2.7e-07 31.1 0.3 8.4e-05 23.0 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EEA05236.1 - 7e-07 29.3 0.0 1.5e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EEA05236.1 - 1.6e-06 28.2 0.2 2.3e-05 24.4 0.0 2.7 2 1 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EEA05236.1 - 4.7e-06 26.4 0.8 3.6e-05 23.6 0.2 2.8 2 1 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA05236.1 - 6.9e-06 26.4 0.4 0.028 14.7 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 EEA05236.1 - 2.5e-05 24.3 0.0 4.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EEA05236.1 - 5.7e-05 22.6 0.0 0.0012 18.3 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EEA05236.1 - 0.00018 21.9 0.4 0.0073 16.7 0.1 2.3 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.15 EEA05236.1 - 0.00032 20.6 0.6 0.19 11.6 0.1 2.4 1 1 1 2 2 2 2 NTPase AAA_3 PF07726.11 EEA05236.1 - 0.00047 20.0 0.0 0.00074 19.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA05236.1 - 0.0012 18.6 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 EEA05236.1 - 0.0014 18.1 0.1 0.085 12.2 0.0 2.8 2 1 1 3 3 3 1 FtsK/SpoIIIE family TniB PF05621.11 EEA05236.1 - 0.0015 18.0 0.1 0.082 12.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein AAA_11 PF13086.6 EEA05236.1 - 0.0016 18.3 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA05236.1 - 0.0042 16.8 0.1 0.013 15.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EEA05236.1 - 0.007 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DNA_pol3_delta PF06144.13 EEA05236.1 - 0.0078 16.0 0.0 0.021 14.6 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_25 PF13481.6 EEA05236.1 - 0.0099 15.5 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EEA05236.1 - 0.01 15.3 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MipZ PF09140.11 EEA05236.1 - 0.02 14.2 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 ATPase MipZ AAA_29 PF13555.6 EEA05236.1 - 0.02 14.6 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 EEA05236.1 - 0.02 13.9 0.0 0.13 11.3 0.0 2.1 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EEA05236.1 - 0.022 14.9 0.0 0.056 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 EEA05236.1 - 0.022 14.5 0.5 0.72 9.6 0.1 2.5 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_assoc_2 PF16193.5 EEA05236.1 - 0.023 15.0 0.0 0.14 12.5 0.0 2.2 1 1 1 2 2 2 0 AAA C-terminal domain RNA_helicase PF00910.22 EEA05236.1 - 0.024 15.0 0.0 0.1 13.0 0.0 2.1 1 1 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EEA05236.1 - 0.024 15.2 0.0 0.052 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EEA05236.1 - 0.026 13.6 0.0 0.067 12.2 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_28 PF13521.6 EEA05236.1 - 0.028 14.7 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EEA05236.1 - 0.037 13.7 0.1 0.17 11.6 0.0 2.1 2 1 0 2 2 2 0 IstB-like ATP binding protein DUF815 PF05673.13 EEA05236.1 - 0.15 11.2 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) GAF PF01590.26 EEA05237.1 - 0.00026 21.6 0.0 0.39 11.3 0.0 3.0 3 0 0 3 3 3 2 GAF domain GAF_2 PF13185.6 EEA05237.1 - 0.14 12.4 0.0 32 4.8 0.0 2.7 2 0 0 2 2 2 0 GAF domain DSPc PF00782.20 EEA05238.1 - 4.1e-26 91.4 0.0 8e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA05238.1 - 0.0028 17.2 0.0 0.005 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase HTH_13 PF11972.8 EEA05238.1 - 0.11 12.6 0.1 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 HTH DNA binding domain PP2C PF00481.21 EEA05239.1 - 9e-18 64.8 0.0 4.8e-10 39.5 0.0 2.9 2 1 0 2 2 2 2 Protein phosphatase 2C Syntaxin_2 PF14523.6 EEA05239.1 - 0.2 12.1 8.9 0.12 12.7 0.7 3.4 3 0 0 3 3 3 0 Syntaxin-like protein Crust_neurohorm PF01147.17 EEA05239.1 - 0.28 11.0 2.9 1.9 8.4 0.1 2.7 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family RMI2 PF16100.5 EEA05240.1 - 0.11 12.3 0.0 1.7 8.4 0.0 2.2 1 1 0 1 1 1 0 RecQ-mediated genome instability protein 2 L27 PF02828.16 EEA05240.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 L27 domain Hom_end PF05204.14 EEA05241.1 - 0.035 14.3 0.7 0.1 12.8 0.3 1.9 2 0 0 2 2 2 0 Homing endonuclease SRP1_TIP1 PF00660.17 EEA05241.1 - 0.068 13.3 0.1 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 Seripauperin and TIP1 family RAWUL PF16207.5 EEA05241.1 - 0.076 13.7 0.3 0.32 11.7 0.0 2.2 2 0 0 2 2 2 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like RBD-FIP PF09457.10 EEA05241.1 - 0.084 12.8 0.6 5.6 7.0 0.0 3.0 2 0 0 2 2 2 0 FIP domain Pkinase PF00069.25 EEA05242.1 - 3.7e-70 236.3 0.0 4.2e-70 236.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05242.1 - 1.6e-35 122.7 0.0 2.1e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA05242.1 - 0.0018 17.3 0.0 0.0058 15.6 0.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EEA05242.1 - 0.013 15.4 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EEA05242.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FAST_1 PF06743.15 EEA05243.1 - 0.0015 18.4 9.6 3.5 7.7 0.0 5.1 4 1 1 5 5 5 3 FAST kinase-like protein, subdomain 1 DUF1040 PF06288.13 EEA05243.1 - 0.12 12.8 0.2 0.55 10.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1040) Sde2_N_Ubi PF13019.6 EEA05244.1 - 1.2e-07 31.7 0.0 1.6e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Phage_TAC_8 PF10666.9 EEA05244.1 - 0.029 14.6 2.5 1.4 9.2 0.3 2.9 1 1 2 3 3 3 0 Phage tail assembly chaperone protein Gp14 ()A118 FAD_binding_2 PF00890.24 EEA05245.1 - 2.9e-116 389.0 1.8 3.5e-116 388.7 1.8 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EEA05245.1 - 1.2e-36 125.5 0.3 1.8e-36 124.9 0.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 EEA05245.1 - 0.0011 18.2 0.1 0.17 10.9 0.3 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EEA05245.1 - 0.0026 17.0 0.0 0.34 10.1 0.0 2.5 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 EEA05245.1 - 0.0041 16.4 0.2 0.051 12.8 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA05245.1 - 0.0065 15.8 0.1 0.013 14.7 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Yae1_N PF09811.9 EEA05246.1 - 0.35 10.6 5.3 0.61 9.8 5.3 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal CRAL_TRIO PF00650.20 EEA05247.1 - 8.3e-26 90.6 0.3 1.8e-25 89.5 0.3 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain DIX PF00778.17 EEA05248.1 - 4.4e-12 45.7 0.1 8.4e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 DIX domain Profilin PF00235.19 EEA05249.1 - 3.4e-21 75.8 0.5 4.2e-21 75.5 0.5 1.1 1 0 0 1 1 1 1 Profilin TMEM52 PF14979.6 EEA05249.1 - 0.12 12.3 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Transmembrane 52 Glyco_hydro_31 PF01055.26 EEA05250.1 - 2e-90 304.1 9.7 5.4e-90 302.7 9.7 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EEA05250.1 - 2.5e-13 50.1 1.5 1.1e-12 48.1 1.5 2.2 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EEA05250.1 - 0.0017 18.6 1.1 0.0067 16.7 0.1 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF5110) DEAD PF00270.29 EEA05251.1 - 3.5e-35 121.3 0.0 8e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA05251.1 - 2.9e-24 85.6 0.1 2.3e-23 82.6 0.1 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA05251.1 - 2.4e-17 62.9 1.9 3.4e-17 62.4 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EEA05251.1 - 5.4e-05 23.3 3.3 6e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EEA05251.1 - 0.11 12.8 0.1 43 4.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain zinc_ribbon_4 PF13717.6 EEA05252.1 - 0.68 9.9 4.6 0.18 11.8 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon domain EcsB PF05975.12 EEA05252.1 - 1.3 7.8 14.5 0.83 8.4 2.6 2.4 3 0 0 3 3 3 0 Bacterial ABC transporter protein EcsB DUF872 PF05915.12 EEA05252.1 - 1.6 8.9 11.2 0.04 14.1 3.5 2.3 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) Med3 PF11593.8 EEA05252.1 - 5.7 6.0 15.5 8.7 5.4 15.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal START PF01852.19 EEA05253.1 - 3.7e-06 26.5 0.0 2.8e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 START domain RNase_P_p30 PF01876.16 EEA05254.1 - 1.1e-36 126.3 3.1 3.3e-31 108.4 1.3 2.9 2 1 0 2 2 2 2 RNase P subunit p30 DUF4520 PF15016.6 EEA05254.1 - 0.12 12.4 0.0 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4520) NPFF PF15085.6 EEA05254.1 - 0.2 12.0 0.0 0.37 11.2 0.0 1.4 1 0 0 1 1 1 0 Neuropeptide FF DUF866 PF05907.13 EEA05255.1 - 8e-39 133.0 0.1 9e-39 132.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Wzy_C PF04932.15 EEA05256.1 - 0.18 11.4 0.0 0.18 11.4 0.0 2.8 2 1 0 2 2 2 0 O-Antigen ligase ResB PF05140.14 EEA05256.1 - 0.18 10.5 0.0 0.33 9.7 0.0 1.3 1 0 0 1 1 1 0 ResB-like family eIF2_C PF09173.11 EEA05257.1 - 1.7e-30 105.1 0.0 4.2e-30 103.8 0.0 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EEA05257.1 - 1.4e-22 80.2 0.4 1.1e-21 77.3 0.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EEA05257.1 - 1e-12 48.3 0.2 3e-12 46.8 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA05257.1 - 0.0024 17.9 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA05257.1 - 0.019 14.8 0.6 0.17 11.8 0.2 2.1 2 0 0 2 2 2 0 RsgA GTPase Dak1_2 PF13684.6 EEA05257.1 - 0.027 13.5 0.4 0.042 12.9 0.4 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Tax PF02959.16 EEA05257.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 HTLV Tax DUF3157 PF11355.8 EEA05258.1 - 0.21 11.2 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3157) TFIIA PF03153.13 EEA05258.1 - 0.71 9.8 19.5 0.89 9.5 19.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Filament PF00038.21 EEA05259.1 - 0.0099 15.5 4.0 0.016 14.8 4.0 1.3 1 1 0 1 1 1 1 Intermediate filament protein DUF5082 PF16888.5 EEA05259.1 - 0.11 12.8 2.8 0.49 10.7 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) TcpS PF17456.2 EEA05259.1 - 0.51 10.4 4.8 3 7.9 4.8 2.2 1 1 0 1 1 1 0 Toxin-coregulated pilus protein S HBS1_N PF08938.10 EEA05260.1 - 0.042 14.2 0.0 0.071 13.4 0.0 1.3 1 0 0 1 1 1 0 HBS1 N-terminus UAA PF08449.11 EEA05262.1 - 6.5e-44 150.3 25.4 1e-43 149.7 25.4 1.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EEA05262.1 - 8.6e-10 38.9 31.6 5e-09 36.4 12.5 3.2 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EEA05262.1 - 2.7e-06 27.0 15.3 0.00074 18.9 5.0 2.3 1 1 1 2 2 2 2 Triose-phosphate Transporter family TPR_2 PF07719.17 EEA05263.1 - 6.3e-07 29.0 0.0 0.027 14.6 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA05263.1 - 0.00019 21.1 5.0 0.011 15.5 0.9 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA05263.1 - 0.00051 20.0 4.6 0.0072 16.5 1.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Methyltransf_12 PF08242.12 EEA05263.1 - 0.0016 19.2 0.9 0.059 14.1 0.0 3.6 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_28 PF02636.17 EEA05263.1 - 0.016 14.8 0.0 0.04 13.5 0.0 1.7 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase TPR_12 PF13424.6 EEA05263.1 - 0.071 13.4 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 EEA05264.1 - 7.7e-73 245.1 0.0 8.9e-73 244.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05264.1 - 6.7e-37 127.2 0.0 8.7e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EEA05264.1 - 0.00023 20.9 0.0 0.12 12.0 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EEA05264.1 - 0.0042 15.9 0.0 0.056 12.2 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 EEA05264.1 - 0.011 15.3 0.4 0.045 13.3 0.3 1.8 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 EEA05264.1 - 0.013 15.4 0.1 0.038 13.9 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA05264.1 - 0.017 14.1 0.0 0.024 13.6 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EEA05264.1 - 0.024 14.0 0.0 0.85 8.9 0.0 2.5 1 1 0 2 2 2 0 Kinase-like Kdo PF06293.14 EEA05264.1 - 0.042 13.2 0.0 0.13 11.6 0.0 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CHCH PF06747.13 EEA05266.1 - 0.00029 20.9 10.1 0.0064 16.6 5.5 2.6 2 1 0 2 2 2 2 CHCH domain CX9C PF16860.5 EEA05266.1 - 0.0037 17.2 11.7 0.078 13.0 3.7 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX6B PF02297.17 EEA05266.1 - 0.23 11.7 11.2 11 6.3 11.2 2.4 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb MRP-L47 PF06984.13 EEA05266.1 - 0.47 10.6 2.6 3 8.0 0.7 2.3 2 1 0 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NDUF_B7 PF05676.13 EEA05266.1 - 1.6 8.5 9.6 11 5.8 1.2 3.0 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) TAF6_C PF07571.13 EEA05267.1 - 6e-05 23.3 0.3 0.0087 16.4 0.1 2.9 2 0 0 2 2 2 2 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EEA05267.1 - 0.025 14.7 0.1 0.07 13.3 0.1 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) Peptidase_C50 PF03568.17 EEA05269.1 - 2e-38 132.5 0.1 2e-38 132.5 0.1 2.8 2 0 0 2 2 2 1 Peptidase family C50 BRCT_2 PF16589.5 EEA05270.1 - 0.029 14.8 2.3 6.3 7.3 0.1 3.6 3 0 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain Arg_decarbox_C PF17944.1 EEA05271.1 - 0.08 13.5 0.1 0.32 11.6 0.1 2.1 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension MRP-S33 PF08293.11 EEA05271.1 - 0.16 12.2 4.2 5.9 7.2 0.3 3.3 3 0 0 3 3 3 0 Mitochondrial ribosomal subunit S27 Rsc14 PF08586.10 EEA05271.1 - 2.1 9.2 10.8 9.3 7.1 0.1 4.4 5 0 0 5 5 5 0 RSC complex, Rsc14/Ldb7 subunit NOT2_3_5 PF04153.18 EEA05272.1 - 2.1e-32 112.0 11.1 4.7e-32 110.8 11.1 1.6 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family BLOC1_2 PF10046.9 EEA05272.1 - 0.033 14.5 1.5 0.033 14.5 1.5 2.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cytochrom_B562 PF07361.11 EEA05272.1 - 0.17 12.6 0.2 0.17 12.6 0.2 2.9 3 1 1 4 4 4 0 Cytochrome b562 Tmemb_cc2 PF10267.9 EEA05272.1 - 0.17 11.0 9.3 0.019 14.1 4.3 1.8 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Tnp_22_trimer PF17489.2 EEA05272.1 - 0.19 11.7 2.8 0.22 11.5 0.0 2.6 2 0 0 2 2 2 0 L1 transposable element trimerization domain Lebercilin PF15619.6 EEA05272.1 - 0.62 9.7 6.2 0.13 12.0 2.4 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CREPT PF16566.5 EEA05272.1 - 0.83 9.8 5.7 14 5.8 2.0 2.3 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1664 PF07889.12 EEA05272.1 - 1.5 8.9 4.3 1.3 9.0 0.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) COG5 PF10392.9 EEA05272.1 - 3.4 7.8 8.4 0.75 10.0 2.7 2.4 1 1 1 2 2 2 0 Golgi transport complex subunit 5 zf-C4H2 PF10146.9 EEA05272.1 - 4.4 7.6 9.5 7.6 6.8 9.5 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein UQ_con PF00179.26 EEA05273.1 - 1.5e-42 144.6 0.0 1.6e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA05273.1 - 1.7e-06 27.7 0.0 2.3e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 EEA05273.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Kin17_mid PF10357.9 EEA05274.1 - 3.4e-42 143.3 6.6 3.4e-42 143.3 6.6 1.5 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EEA05274.1 - 0.0031 17.9 3.3 0.0067 16.8 3.3 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA05274.1 - 0.0061 16.8 2.7 0.015 15.6 2.7 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding CAS_C PF12026.8 EEA05274.1 - 0.91 9.6 5.4 1.6 8.8 2.9 2.1 2 0 0 2 2 2 0 Crk-Associated Substrate C-terminal domain UQ_con PF00179.26 EEA05277.1 - 5e-46 155.8 0.2 5.7e-46 155.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA05277.1 - 2.1e-05 24.2 0.0 2.7e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA05277.1 - 0.052 13.8 2.3 0.13 12.5 2.3 1.8 1 1 0 1 1 1 0 RWD domain Peptidase_C1 PF00112.23 EEA05278.1 - 2.7e-40 138.8 9.3 4.8e-40 138.0 9.3 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EEA05278.1 - 0.0077 15.1 0.5 0.041 12.7 0.3 2.2 2 1 1 3 3 3 1 Peptidase C1-like family PEP-utilizers_C PF02896.18 EEA05279.1 - 0.025 13.7 0.4 0.055 12.6 0.4 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain Mucin-like PF16058.5 EEA05280.1 - 0.32 11.1 2.0 0.89 9.7 2.0 1.7 1 0 0 1 1 1 0 Mucin-like SLBP_RNA_bind PF15247.6 EEA05281.1 - 3.4e-22 78.3 2.4 6.5e-22 77.4 2.4 1.5 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain TFIID_20kDa PF03847.13 EEA05281.1 - 0.00095 19.6 0.0 0.0025 18.3 0.0 1.7 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TAFII28 PF04719.14 EEA05281.1 - 0.018 15.1 0.0 0.13 12.3 0.0 2.4 2 0 0 2 2 2 0 hTAFII28-like protein conserved region JAB PF01398.21 EEA05282.1 - 3.9e-30 104.2 0.1 5.8e-30 103.7 0.1 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EEA05282.1 - 7.7e-26 90.7 0.2 1.3e-25 90.0 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Pox_MCEL PF03291.16 EEA05283.1 - 7.5e-41 140.3 8.1 7.4e-39 133.8 8.1 2.4 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_31 PF13847.6 EEA05283.1 - 1.4e-13 50.9 0.0 2.5e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA05283.1 - 4.2e-13 49.8 0.0 1.2e-12 48.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA05283.1 - 5e-12 46.4 0.3 1.3e-11 45.1 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA05283.1 - 6.3e-10 39.6 0.0 1.3e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA05283.1 - 8.2e-08 32.3 0.0 1.9e-07 31.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EEA05283.1 - 0.0014 17.9 0.0 0.0029 16.9 0.0 1.5 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_15 PF09445.10 EEA05283.1 - 0.0092 15.6 0.1 0.026 14.1 0.1 1.8 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_5 PF01795.19 EEA05283.1 - 0.02 14.4 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 MraW methylase family Methyltransf_18 PF12847.7 EEA05283.1 - 0.068 13.1 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EEA05283.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) MCM PF00493.23 EEA05284.1 - 9.6e-97 322.5 0.4 9.6e-97 322.5 0.4 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EEA05284.1 - 5.7e-31 107.0 0.1 9.7e-31 106.2 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA05284.1 - 6.3e-25 87.4 2.8 1.5e-24 86.2 2.8 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA05284.1 - 1.2e-06 29.0 0.2 0.011 16.3 0.1 2.5 2 0 0 2 2 2 2 MCM N-terminal domain Mg_chelatase PF01078.21 EEA05284.1 - 3.7e-06 26.5 0.0 2.8e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EEA05284.1 - 0.011 15.7 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EEA05284.1 - 0.035 13.8 0.0 0.095 12.4 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 EEA05284.1 - 0.13 12.2 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Leptin PF02024.15 EEA05285.1 - 0.0047 16.7 0.2 0.028 14.2 0.1 2.3 1 1 1 2 2 2 1 Leptin InvH PF04741.12 EEA05285.1 - 0.02 14.8 1.1 0.041 13.8 0.2 2.0 2 0 0 2 2 2 0 InvH outer membrane lipoprotein Phage_Gp23 PF10669.9 EEA05285.1 - 0.024 14.9 0.6 0.024 14.9 0.6 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) DUF719 PF05334.13 EEA05285.1 - 0.36 11.0 4.8 2.2 8.4 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) CTP_transf_like PF01467.26 EEA05286.1 - 5.3e-32 111.0 0.0 2.2e-16 60.4 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EEA05286.1 - 0.0019 18.1 0.1 0.31 10.9 0.0 2.5 2 0 0 2 2 2 2 FAD synthetase Pantoate_ligase PF02569.15 EEA05286.1 - 0.022 14.0 0.0 0.42 9.8 0.0 2.2 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase DUF5393 PF17371.2 EEA05287.1 - 1.1 7.2 12.6 1.7 6.7 12.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5393) Hexapep PF00132.24 EEA05288.1 - 1.4e-07 31.0 5.5 3.6e-05 23.3 0.1 4.0 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EEA05288.1 - 0.1 11.5 0.0 0.14 11.0 0.0 1.3 1 1 0 1 1 1 0 L-fucokinase RRM_occluded PF16842.5 EEA05289.1 - 0.074 12.9 0.1 0.82 9.6 0.0 2.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif Zn_clus PF00172.18 EEA05289.1 - 0.29 11.3 7.1 0.71 10.0 7.1 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MyTH4 PF00784.17 EEA05290.1 - 8.4e-12 45.5 0.1 2.9e-11 43.8 0.1 1.9 1 0 0 1 1 1 1 MyTH4 domain IPK PF03770.16 EEA05291.1 - 9e-15 55.0 1.5 2.6e-13 50.3 1.5 2.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase LRR_8 PF13855.6 EEA05292.1 - 5.9e-06 26.0 0.8 5.9e-06 26.0 0.8 3.1 3 0 0 3 3 3 1 Leucine rich repeat LRR_6 PF13516.6 EEA05292.1 - 0.0029 17.5 0.9 0.43 10.8 0.0 3.4 3 0 0 3 3 3 1 Leucine Rich repeat PIN_9 PF18477.1 EEA05292.1 - 0.028 14.7 0.1 0.062 13.6 0.1 1.5 1 0 0 1 1 1 0 PIN like domain APP_N PF02177.16 EEA05292.1 - 0.066 13.6 0.2 0.82 10.1 0.0 2.5 2 0 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding Striatin PF08232.12 EEA05292.1 - 0.94 10.1 4.9 0.41 11.2 0.8 2.1 2 0 0 2 2 2 0 Striatin family Maf1 PF09174.10 EEA05293.1 - 1.6e-38 132.6 2.9 3.3e-38 131.6 2.9 1.5 1 1 0 1 1 1 1 Maf1 regulator Rhomboid PF01694.22 EEA05295.1 - 8.7e-25 87.5 16.1 8.7e-25 87.5 16.1 1.9 2 0 0 2 2 2 1 Rhomboid family Wzy_C PF04932.15 EEA05295.1 - 0.47 10.1 0.0 0.47 10.1 0.0 3.2 2 1 1 4 4 4 0 O-Antigen ligase HEAT_EZ PF13513.6 EEA05296.1 - 4.8e-12 46.1 9.0 1.1e-07 32.2 0.0 6.9 6 1 1 7 7 7 1 HEAT-like repeat HEAT PF02985.22 EEA05296.1 - 7.7e-09 35.1 11.8 0.0013 18.8 0.1 8.9 9 0 0 9 9 9 1 HEAT repeat IBN_N PF03810.19 EEA05296.1 - 1.8e-07 31.0 5.0 2.9e-07 30.3 0.4 3.5 4 0 0 4 4 4 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EEA05296.1 - 0.0001 22.8 0.5 1.7 9.3 0.0 3.7 2 1 0 2 2 2 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EEA05296.1 - 0.00086 19.4 0.1 0.023 14.7 0.0 3.3 2 2 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EEA05296.1 - 2.2 8.4 10.7 46 4.3 0.2 4.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Pkinase PF00069.25 EEA05298.1 - 1.2e-34 119.9 0.2 7.5e-34 117.3 0.2 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05298.1 - 8.5e-06 25.2 0.0 2.5e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase GCP_C_terminal PF04130.13 EEA05299.1 - 2e-25 89.9 9.4 2e-25 89.9 9.4 2.1 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EEA05299.1 - 3.6e-23 82.7 6.5 1.7e-22 80.5 4.5 2.5 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal MbtH PF03621.13 EEA05299.1 - 0.067 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 MbtH-like protein PTPlike_phytase PF14566.6 EEA05300.1 - 0.0017 18.5 0.4 0.0027 17.8 0.4 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Tropomyosin_1 PF12718.7 EEA05300.1 - 0.13 12.4 2.3 0.22 11.7 2.3 1.3 1 0 0 1 1 1 0 Tropomyosin like Bac_GDH PF05088.12 EEA05300.1 - 0.14 9.6 0.2 0.19 9.2 0.2 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase ATG16 PF08614.11 EEA05300.1 - 0.22 11.7 1.6 0.33 11.1 1.6 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) EzrA PF06160.12 EEA05300.1 - 0.25 9.5 2.1 0.18 10.0 0.6 1.4 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Pkinase PF00069.25 EEA05301.1 - 1.3e-44 152.6 0.0 9.1e-29 100.6 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05301.1 - 7.7e-24 84.4 0.0 9.8e-18 64.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA05301.1 - 4e-06 25.9 0.1 6.4e-06 25.2 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EEA05301.1 - 0.0026 17.1 0.1 1.3 8.3 0.1 2.4 2 0 0 2 2 2 2 Kinase-like LsmAD PF06741.13 EEA05303.1 - 6.7e-15 55.4 2.1 6.7e-15 55.4 2.1 2.4 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 EEA05303.1 - 2.3e-06 27.7 0.0 4.6e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 EEA05303.1 - 0.0036 16.9 1.2 0.0079 15.8 1.2 1.5 1 0 0 1 1 1 1 Ataxin-2 C-terminal region FdhD-NarQ PF02634.15 EEA05303.1 - 0.22 11.2 0.8 0.39 10.3 0.8 1.4 1 0 0 1 1 1 0 FdhD/NarQ family MMU163 PF17119.5 EEA05303.1 - 0.43 9.7 3.1 1.1 8.3 2.7 1.9 1 1 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis S1-P1_nuclease PF02265.16 EEA05304.1 - 1.7e-22 80.5 0.0 3.1e-22 79.6 0.0 1.4 1 1 0 1 1 1 1 S1/P1 Nuclease TPP_enzyme_N PF02776.18 EEA05305.1 - 3.3e-26 91.9 0.0 1.6e-25 89.7 0.0 2.1 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EEA05305.1 - 4.3e-22 78.3 0.0 2.6e-21 75.8 0.0 2.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EEA05305.1 - 1.4e-17 63.9 0.0 4.1e-17 62.4 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 EEA05305.1 - 0.025 14.4 0.1 0.06 13.1 0.1 1.6 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit COPIIcoated_ERV PF07970.12 EEA05306.1 - 4e-58 196.9 1.3 5.6e-58 196.4 1.3 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EEA05306.1 - 6.4e-24 84.1 0.3 6.4e-24 84.1 0.3 2.1 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CBP_BcsR PF10945.8 EEA05306.1 - 0.13 11.8 0.1 1.8 8.1 0.0 2.7 3 0 0 3 3 3 0 Cellulose biosynthesis protein BcsR zf-RanBP PF00641.18 EEA05306.1 - 3.4 7.1 6.7 0.42 10.0 0.1 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Allexi_40kDa PF05549.11 EEA05307.1 - 0.052 13.0 3.4 0.079 12.5 3.4 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein UPF0242 PF06785.11 EEA05307.1 - 0.062 13.4 5.7 0.066 13.3 5.1 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fzo_mitofusin PF04799.13 EEA05307.1 - 0.67 9.5 8.9 0.94 9.0 1.6 2.7 2 1 0 2 2 2 0 fzo-like conserved region LMBR1 PF04791.16 EEA05308.1 - 2.6e-116 389.5 38.1 3e-116 389.3 38.1 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Scs3p PF10261.9 EEA05309.1 - 0.00068 19.2 4.2 0.00092 18.8 2.6 2.0 2 1 0 2 2 2 1 Inositol phospholipid synthesis and fat-storage-inducing TM SPASM PF13186.6 EEA05309.1 - 0.099 13.2 0.1 0.7 10.4 0.0 2.3 2 0 0 2 2 2 0 Iron-sulfur cluster-binding domain Thioredoxin PF00085.20 EEA05310.1 - 2e-05 24.5 0.0 3.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EEA05310.1 - 0.00014 20.9 0.6 0.00017 20.6 0.6 1.1 1 0 0 1 1 1 1 Phosducin DUF4510 PF14971.6 EEA05310.1 - 0.17 12.3 0.4 0.26 11.6 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4510) Cpn60_TCP1 PF00118.24 EEA05311.1 - 5.2e-150 500.3 8.7 5.9e-150 500.1 8.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA_7 PF12775.7 EEA05311.1 - 0.15 11.6 0.1 0.33 10.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region zf-CCCH PF00642.24 EEA05312.1 - 6.1e-06 26.0 3.9 8.3e-05 22.4 0.8 2.6 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EEA05312.1 - 6.1e-06 26.4 0.5 6.8e-05 23.0 0.3 2.3 2 0 0 2 2 2 1 Zinc-finger containing family Torus PF16131.5 EEA05312.1 - 0.0034 18.1 3.7 0.012 16.4 0.6 2.5 1 1 1 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 EEA05312.1 - 0.0041 17.1 7.1 0.028 14.5 3.0 3.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 EEA05312.1 - 0.025 14.4 10.4 0.026 14.4 1.7 3.3 3 0 0 3 3 3 0 CCCH-type zinc finger zf-CCCH PF00642.24 EEA05313.1 - 4e-08 33.0 13.6 9.7e-05 22.2 1.3 3.3 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EEA05313.1 - 7.7e-05 22.9 7.1 0.00098 19.3 1.0 2.5 1 1 1 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 EEA05313.1 - 0.01 15.9 1.5 0.01 15.9 1.5 3.5 3 0 0 3 3 3 0 Zinc finger domain Torus PF16131.5 EEA05313.1 - 0.15 12.8 13.7 0.12 13.1 2.1 3.2 1 1 2 3 3 3 0 Torus domain zf-CCCH_4 PF18044.1 EEA05313.1 - 2.7 7.9 18.9 1.6 8.6 4.5 3.6 4 0 0 4 4 4 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EEA05313.1 - 4.1 8.0 15.9 33 5.1 1.2 3.7 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.9 EEA05313.1 - 5.9 6.7 7.6 16 5.4 0.3 2.9 3 0 0 3 3 3 0 Putative zinc-finger domain DHHC PF01529.20 EEA05314.1 - 1.2e-33 116.1 12.7 1.2e-33 116.1 12.7 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase Rod_cone_degen PF15201.6 EEA05314.1 - 0.0075 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Progressive rod-cone degeneration DUF35_N PF12172.8 EEA05314.1 - 0.047 13.6 4.1 0.12 12.2 4.1 1.7 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF2269 PF10027.9 EEA05314.1 - 6 6.9 8.5 0.33 11.0 2.3 1.9 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) DUF5089 PF17002.5 EEA05316.1 - 0.0024 17.8 9.1 0.005 16.7 9.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) DUF5497 PF17601.2 EEA05316.1 - 0.44 10.9 6.1 3.1 8.2 1.4 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5497) SLBP_RNA_bind PF15247.6 EEA05317.1 - 3e-21 75.3 0.8 3e-21 75.3 0.8 1.9 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain DNA_RNApol_7kD PF03604.13 EEA05318.1 - 4.6e-15 55.0 5.8 6.3e-15 54.6 5.8 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 EEA05318.1 - 0.0033 17.4 0.8 0.0036 17.3 0.8 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EEA05318.1 - 0.0074 16.3 1.2 0.01 15.9 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_10 PF10058.9 EEA05318.1 - 0.011 15.4 0.6 0.05 13.3 0.0 2.0 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF2757 PF10955.8 EEA05318.1 - 0.025 14.8 0.2 0.034 14.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) DUF1451 PF07295.11 EEA05318.1 - 0.069 13.2 1.0 0.079 13.0 1.0 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-RRN7 PF11781.8 EEA05318.1 - 0.085 12.6 3.5 4.4 7.1 0.6 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 GFA PF04828.14 EEA05318.1 - 0.098 13.0 2.8 4.2 7.8 0.5 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn-ribbon_8 PF09723.10 EEA05318.1 - 0.13 12.4 2.7 0.26 11.4 2.7 1.6 1 1 0 1 1 1 0 Zinc ribbon domain zf_UBZ PF18439.1 EEA05318.1 - 0.17 11.5 1.9 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn_Tnp_IS1595 PF12760.7 EEA05318.1 - 0.5 10.4 5.8 1.9 8.5 1.9 2.1 1 1 0 2 2 2 0 Transposase zinc-ribbon domain Rubredoxin_2 PF18073.1 EEA05318.1 - 0.54 10.0 0.0 0.54 10.0 0.0 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain Bac_export_2 PF01312.19 EEA05319.1 - 5.7 6.0 5.8 7.6 5.6 5.8 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family ALS2CR11 PF15729.5 EEA05320.1 - 0.27 10.3 0.4 0.38 9.8 0.4 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 PhoR PF11808.8 EEA05320.1 - 0.54 10.7 4.2 1.5 9.3 0.2 2.6 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR SWIB PF02201.18 EEA05321.1 - 2e-05 24.3 0.2 8.6e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 SWIB/MDM2 domain NPHI_C PF08469.10 EEA05321.1 - 0.0015 18.5 1.0 0.0032 17.5 0.1 1.9 2 1 1 3 3 3 1 Nucleoside triphosphatase I C-terminal Ribosomal_L28e PF01778.17 EEA05321.1 - 0.65 10.8 5.7 0.26 12.0 1.0 2.4 1 1 1 2 2 2 0 Ribosomal L28e protein family Importin_rep_4 PF18808.1 EEA05322.1 - 5.8e-17 61.8 3.6 3.2e-15 56.2 1.2 4.7 4 1 0 4 4 4 1 Importin repeat HEAT PF02985.22 EEA05322.1 - 4.6e-14 51.3 4.0 5e-05 23.2 0.0 8.6 8 0 0 8 8 7 2 HEAT repeat HEAT_EZ PF13513.6 EEA05322.1 - 2.6e-12 46.9 0.0 0.00028 21.3 0.0 6.8 6 1 2 8 8 6 2 HEAT-like repeat IFRD PF05004.13 EEA05322.1 - 3.8e-11 42.7 0.1 3.6e-05 23.0 0.0 5.4 3 2 2 5 5 5 2 Interferon-related developmental regulator (IFRD) RIX1 PF08167.12 EEA05322.1 - 1.7e-08 34.4 4.2 0.014 15.1 0.1 5.9 5 1 1 6 6 6 3 rRNA processing/ribosome biogenesis HEAT_2 PF13646.6 EEA05322.1 - 4.5e-08 33.4 0.1 0.00061 20.1 0.0 5.7 4 2 2 6 6 6 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EEA05322.1 - 2.5e-07 31.2 3.4 0.022 15.3 0.0 6.1 5 2 2 7 7 6 1 Vacuolar 14 Fab1-binding region UME PF08064.13 EEA05322.1 - 5.9e-07 29.3 3.0 1.4 8.8 0.0 6.9 5 1 1 6 6 6 2 UME (NUC010) domain Tti2 PF10521.9 EEA05322.1 - 9.2e-06 25.4 0.2 0.12 11.8 0.0 5.0 3 2 1 4 4 4 1 Tti2 family Ecm29 PF13001.7 EEA05322.1 - 0.00013 20.8 0.4 0.041 12.6 0.0 4.0 3 1 1 4 4 4 1 Proteasome stabiliser MMS19_N PF14500.6 EEA05322.1 - 0.0013 18.4 0.3 1 8.9 0.0 3.4 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 EEA05322.1 - 0.0024 17.8 0.2 3.8 7.7 0.0 4.4 5 0 0 5 5 3 1 Armadillo/beta-catenin-like repeat DUF4042 PF13251.6 EEA05322.1 - 0.024 14.3 2.5 8.9 6.0 0.0 5.0 6 0 0 6 6 6 0 Domain of unknown function (DUF4042) Clathrin PF00637.20 EEA05322.1 - 0.027 14.4 0.7 0.13 12.2 0.3 2.5 2 0 0 2 2 2 0 Region in Clathrin and VPS DUF5578 PF17741.1 EEA05322.1 - 0.04 13.3 0.0 0.58 9.5 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5578) IBN_N PF03810.19 EEA05322.1 - 0.058 13.3 3.1 1.3 9.0 0.2 3.8 4 0 0 4 4 3 0 Importin-beta N-terminal domain TFCD_C PF12612.8 EEA05322.1 - 0.085 12.7 0.0 1.6 8.5 0.0 3.1 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal UPF0172 PF03665.13 EEA05323.1 - 1.2e-35 123.4 0.0 1.4e-35 123.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 EEA05323.1 - 0.0031 17.5 0.0 0.0047 16.9 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CLPTM1 PF05602.12 EEA05325.1 - 1.5e-98 330.6 15.0 1.5e-98 330.6 15.0 1.4 2 0 0 2 2 2 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EEA05325.1 - 0.0039 16.9 4.2 0.03 14.1 0.8 3.3 2 1 0 2 2 2 1 PQ loop repeat ER_lumen_recept PF00810.18 EEA05326.1 - 2.5e-26 93.2 11.7 5.2e-26 92.2 11.7 1.5 1 0 0 1 1 1 1 ER lumen protein retaining receptor CdhC PF03598.15 EEA05326.1 - 0.21 11.4 0.1 10 5.9 0.0 2.3 2 0 0 2 2 2 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit Bac_rhodopsin PF01036.18 EEA05326.1 - 0.79 9.2 10.4 0.046 13.3 1.1 2.4 3 0 0 3 3 3 0 Bacteriorhodopsin-like protein Urm1 PF09138.11 EEA05327.1 - 3.8e-31 107.3 0.4 4.2e-31 107.2 0.4 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EEA05327.1 - 0.016 15.8 0.0 0.022 15.4 0.0 1.4 1 1 0 1 1 1 0 ThiS family FHA PF00498.26 EEA05328.1 - 3.4e-18 65.7 1.5 4.3e-11 43.0 0.6 2.8 2 0 0 2 2 2 2 FHA domain zf-C3HC4_3 PF13920.6 EEA05328.1 - 4.2e-09 36.1 9.6 9.4e-09 35.0 9.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA05328.1 - 2.1e-07 30.9 8.8 2.1e-07 30.9 8.8 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA05328.1 - 3.2e-07 30.1 13.7 6.6e-07 29.1 13.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA05328.1 - 9.7e-07 28.8 11.6 3.1e-06 27.2 11.7 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EEA05328.1 - 1.5e-05 24.7 12.5 3.6e-05 23.5 12.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA05328.1 - 3.6e-05 24.0 13.1 3.6e-05 24.0 13.1 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EEA05328.1 - 0.00078 19.3 12.2 0.0018 18.2 12.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EEA05328.1 - 0.0058 16.8 5.6 0.015 15.4 5.6 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EEA05328.1 - 0.015 15.2 6.0 0.05 13.5 6.0 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EEA05328.1 - 0.021 14.6 16.2 0.015 15.1 12.1 2.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EEA05328.1 - 1 9.2 9.6 4.6 7.1 9.9 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EEA05328.1 - 3.3 7.6 6.6 8.8 6.2 6.6 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EEA05328.1 - 6.1 7.2 13.0 5.1 7.5 9.9 2.5 2 1 0 2 2 2 0 RING-H2 zinc finger domain ELMO_CED12 PF04727.13 EEA05329.1 - 4.2e-46 157.3 0.0 5.7e-46 156.8 0.0 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family Pigment_DH PF06324.11 EEA05329.1 - 0.14 12.3 0.7 2.3 8.5 0.1 2.8 2 0 0 2 2 2 0 Pigment-dispersing hormone (PDH) Topoisom_I PF01028.20 EEA05330.1 - 3.9e-102 340.4 7.5 1.1e-101 338.9 7.5 1.8 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EEA05330.1 - 3.8e-84 281.5 6.4 3.8e-84 281.5 6.4 2.5 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EEA05330.1 - 1e-29 102.3 0.8 1e-29 102.3 0.8 2.3 2 0 0 2 2 2 1 C-terminal topoisomerase domain YnfE PF17452.2 EEA05330.1 - 0.17 12.2 2.1 1.5 9.2 0.0 3.1 2 0 0 2 2 2 0 Uncharacterized YnfE-like Peptidase_S49_N PF08496.10 EEA05330.1 - 0.77 9.8 3.7 14 5.7 1.3 2.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Patatin PF01734.22 EEA05334.1 - 6.8e-14 52.5 0.0 1.4e-13 51.5 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Plant_NMP1 PF06694.11 EEA05334.1 - 0.033 13.3 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) Sterile PF03015.19 EEA05334.1 - 0.076 13.2 0.0 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 Male sterility protein DUF5101 PF17031.5 EEA05334.1 - 0.084 13.0 0.6 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) NPL PF17800.1 EEA05335.1 - 0.19 12.3 1.3 1.7 9.2 0.1 2.4 1 1 1 2 2 2 0 Nucleoplasmin-like domain SNF5 PF04855.12 EEA05337.1 - 0.0047 16.7 0.3 0.011 15.5 0.1 1.6 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 HNF-1_N PF04814.13 EEA05337.1 - 0.032 14.8 2.0 0.52 10.9 0.0 2.7 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Pyr_redox_2 PF07992.14 EEA05338.1 - 6.9e-51 173.2 0.0 9.5e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EEA05338.1 - 9.5e-32 109.5 0.2 4.6e-31 107.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EEA05338.1 - 4e-18 65.7 0.1 1.2e-17 64.2 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA05338.1 - 8e-09 35.2 0.1 1.2e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EEA05338.1 - 0.0014 17.9 0.0 0.18 10.9 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 EEA05338.1 - 0.0023 17.3 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EEA05338.1 - 0.033 13.4 1.8 4.1 6.5 0.5 2.2 1 1 1 2 2 2 0 FAD binding domain 3HCDH_N PF02737.18 EEA05338.1 - 0.057 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase_Tyr PF07714.17 EEA05339.1 - 3.5e-50 170.7 0.0 1e-49 169.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EEA05339.1 - 5.8e-50 170.1 0.1 2.2e-49 168.2 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EEA05339.1 - 0.00064 19.1 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA05339.1 - 0.00094 18.6 0.0 0.0027 17.0 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Synaptobrevin PF00957.21 EEA05340.1 - 2.7e-06 27.1 0.1 7.9e-06 25.6 0.1 1.7 1 0 0 1 1 1 1 Synaptobrevin HTH_WhiA PF02650.14 EEA05340.1 - 0.076 13.4 0.5 0.14 12.5 0.5 1.5 1 0 0 1 1 1 0 WhiA C-terminal HTH domain MFS_1 PF07690.16 EEA05341.1 - 3.7e-23 82.0 41.1 1.8e-21 76.5 7.0 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA05341.1 - 4.5e-16 58.8 6.8 4.5e-16 58.8 6.8 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EEA05341.1 - 0.0066 14.8 34.0 0.0085 14.4 16.3 4.3 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Gag_p12 PF01141.18 EEA05341.1 - 0.11 12.9 0.2 0.21 11.9 0.2 1.4 1 0 0 1 1 1 0 Gag polyprotein, inner coat protein p12 tRNA_int_end_N2 PF12928.7 EEA05342.1 - 0.00014 21.9 0.1 0.00066 19.8 0.0 2.1 2 1 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term Na_Ca_ex PF01699.24 EEA05343.1 - 3.3e-10 40.1 5.3 4e-10 39.8 5.3 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein CTP_transf_like PF01467.26 EEA05345.1 - 0.0015 18.7 0.0 0.0031 17.7 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like Ribosomal_L1 PF00687.21 EEA05346.1 - 6.7e-42 143.5 1.9 6.7e-42 143.5 1.9 1.8 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family YtzH PF14165.6 EEA05346.1 - 0.029 14.8 0.9 0.097 13.1 0.3 2.2 2 1 0 2 2 2 0 YtzH-like protein Leo1 PF04004.13 EEA05347.1 - 2.6e-06 27.4 0.1 8.3e-06 25.7 0.0 1.9 2 1 0 2 2 2 1 Leo1-like protein Helicase_C_2 PF13307.6 EEA05348.1 - 3.8e-46 157.4 0.0 1.2e-45 155.8 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EEA05348.1 - 1.1e-37 129.3 2.0 1.1e-37 129.3 2.0 2.3 3 0 0 3 3 3 1 DEAD_2 ResIII PF04851.15 EEA05348.1 - 9.7e-05 22.4 0.5 0.26 11.3 0.2 2.9 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit ArenaCapSnatch PF17296.2 EEA05348.1 - 0.012 15.1 0.1 0.051 13.0 0.1 2.1 2 0 0 2 2 2 0 Arenavirus cap snatching domain GATA PF00320.27 EEA05350.1 - 0.0029 17.2 4.8 0.052 13.2 4.8 2.6 1 1 0 1 1 1 1 GATA zinc finger CBFD_NFYB_HMF PF00808.23 EEA05351.1 - 1.3e-08 35.0 0.0 1.7e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA05351.1 - 0.05 14.0 0.1 0.064 13.6 0.1 1.1 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 NigD_N PF12667.7 EEA05351.1 - 0.087 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 NigD-like N-terminal OB domain Delta_lysin PF05372.11 EEA05352.1 - 2.3 7.6 5.1 0.47 9.8 0.5 2.3 2 0 0 2 2 2 0 Delta lysin family Tetraspanin PF00335.20 EEA05352.1 - 7.9 6.1 21.2 6 6.5 15.9 2.5 2 1 0 2 2 2 0 Tetraspanin family Alpha_adaptinC2 PF02883.20 EEA05353.1 - 5.7e-07 29.8 0.0 2.7e-06 27.6 0.0 2.3 1 0 0 1 1 1 1 Adaptin C-terminal domain SAPIS-gp6 PF16722.5 EEA05353.1 - 0.054 13.9 0.5 0.054 13.9 0.5 2.8 3 0 0 3 3 3 0 Pathogenicity island protein gp6 in Staphylococcus Pkinase PF00069.25 EEA05354.1 - 2.6e-62 210.6 0.2 5.7e-62 209.5 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05354.1 - 2.1e-23 82.9 0.5 3.2e-21 75.8 0.5 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EEA05354.1 - 0.0013 18.4 0.1 0.17 11.5 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EEA05354.1 - 0.0021 17.4 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA05354.1 - 0.0045 15.8 0.0 0.0073 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase SNF2_N PF00176.23 EEA05355.1 - 2.5e-67 227.1 1.3 5.5e-67 225.9 1.3 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA05355.1 - 4e-20 72.2 0.1 2.6e-18 66.4 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 EEA05355.1 - 2.3e-13 50.2 1.6 9.2e-13 48.3 1.2 2.4 1 1 0 1 1 1 1 HSA ResIII PF04851.15 EEA05355.1 - 2.9e-07 30.7 0.2 1.3e-06 28.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PA28_beta PF02252.18 EEA05356.1 - 2.9e-55 185.9 0.1 4.4e-55 185.4 0.1 1.3 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 EEA05356.1 - 0.069 13.2 0.3 0.35 10.9 0.0 2.3 3 0 0 3 3 3 0 Proteasome activator pa28 alpha subunit tRNA-synt_1 PF00133.22 EEA05357.1 - 1.3e-183 611.6 0.1 2.2e-182 607.5 0.0 2.3 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA05357.1 - 1e-31 110.0 1.3 3.8e-31 108.1 1.3 2.1 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EEA05357.1 - 2.2e-15 56.3 3.1 1.9e-07 30.2 0.1 4.5 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EEA05357.1 - 9.7e-08 31.7 0.1 2.5e-06 27.1 0.0 2.4 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EEA05357.1 - 0.0049 16.3 0.8 0.032 13.6 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain ANAPC4_WD40 PF12894.7 EEA05358.1 - 1.8e-08 34.6 0.0 0.28 11.5 0.0 5.1 3 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA05358.1 - 2e-07 31.6 15.3 0.09 13.7 0.6 8.3 9 0 0 9 9 9 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EEA05358.1 - 0.00034 19.7 0.1 0.027 13.4 0.0 3.6 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EEA05358.1 - 0.023 13.4 0.7 9.4 4.7 0.0 3.2 2 1 1 3 3 3 0 Nucleoporin Nup120/160 BCAS3 PF12490.8 EEA05358.1 - 0.057 12.9 0.1 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 3 AP2 PF00847.20 EEA05360.1 - 7e-14 51.8 3.5 1.4e-13 50.8 3.5 1.5 1 0 0 1 1 1 1 AP2 domain COG5 PF10392.9 EEA05362.1 - 0.031 14.5 0.3 0.058 13.6 0.2 1.4 1 1 1 2 2 2 0 Golgi transport complex subunit 5 UPF0181 PF03701.14 EEA05362.1 - 0.047 13.3 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) ParA PF10609.9 EEA05363.1 - 1.1e-83 280.4 0.1 1.4e-83 280.1 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EEA05363.1 - 3.7e-10 39.9 0.0 5.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EEA05363.1 - 1.2e-07 31.8 0.1 5.7e-07 29.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EEA05363.1 - 3.5e-05 23.1 2.1 0.0005 19.4 0.0 2.8 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EEA05363.1 - 0.00041 19.7 0.0 0.00086 18.7 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 EEA05363.1 - 0.0032 16.9 0.2 2.7 7.4 0.0 2.4 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Rad17 PF03215.15 EEA05363.1 - 0.015 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain NB-ARC PF00931.22 EEA05363.1 - 0.02 14.1 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 EEA05363.1 - 0.029 14.3 0.5 0.26 11.2 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase CLP1_P PF16575.5 EEA05363.1 - 0.036 13.8 0.1 0.55 10.0 0.0 2.3 2 1 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF4535 PF15054.6 EEA05363.1 - 0.045 13.5 0.9 3 7.6 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4535) Zeta_toxin PF06414.12 EEA05363.1 - 0.079 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_26 PF13500.6 EEA05363.1 - 0.081 12.7 0.4 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EEA05363.1 - 0.19 11.7 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EEA05363.1 - 0.25 10.9 0.0 0.51 9.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Fcf2 PF08698.11 EEA05364.1 - 2.4e-23 82.3 0.4 4.5e-23 81.4 0.0 1.7 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing RNase_H2_suC PF08615.11 EEA05365.1 - 1.9e-12 47.5 0.1 2.8e-08 34.0 0.0 2.0 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PTH2 PF01981.16 EEA05366.1 - 1e-43 148.3 0.0 1.2e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Condensin2nSMC PF12422.8 EEA05367.1 - 5.1e-44 150.1 2.7 1.2e-43 148.9 0.2 3.0 4 0 0 4 4 4 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 EEA05367.1 - 0.00022 21.2 0.6 0.7 10.3 0.0 3.9 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 EEA05367.1 - 0.092 13.1 0.0 0.54 10.7 0.0 2.3 2 1 0 2 2 2 0 HEAT repeats ERO1 PF04137.15 EEA05368.1 - 3e-33 115.5 11.0 4.4e-31 108.4 11.0 2.8 1 1 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Clr5 PF14420.6 EEA05368.1 - 0.12 12.6 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 Clr5 domain Peptidase_C12 PF01088.21 EEA05369.1 - 9.8e-43 146.3 0.0 1.3e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UvrD-helicase PF00580.21 EEA05370.1 - 8.4e-54 183.2 3.3 8.4e-54 183.2 3.3 2.4 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EEA05370.1 - 8.1e-39 134.0 7.9 4.6e-31 108.5 0.1 3.2 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EEA05370.1 - 7.4e-22 78.3 0.0 5.8e-21 75.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EEA05370.1 - 6.1e-11 42.0 0.1 0.00027 20.7 0.0 2.4 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EEA05370.1 - 0.00038 20.2 0.0 0.001 18.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EEA05370.1 - 0.01 15.9 6.1 0.05 13.6 0.1 3.3 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Terminase_6 PF03237.15 EEA05370.1 - 0.02 14.5 0.6 0.087 12.5 0.1 2.2 2 0 0 2 2 2 0 Terminase-like family CobT PF06213.12 EEA05370.1 - 3.5 6.9 5.0 0.33 10.3 0.1 1.7 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF3223 PF11523.8 EEA05371.1 - 5.8e-20 71.9 3.1 3.7e-19 69.3 0.2 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3223) La PF05383.17 EEA05371.1 - 1.3e-13 50.8 0.3 2.8e-13 49.7 0.3 1.6 1 0 0 1 1 1 1 La domain DUF2164 PF09932.9 EEA05371.1 - 0.37 10.9 1.9 1.4 9.0 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) AP2 PF00847.20 EEA05372.1 - 4.1e-12 46.1 2.1 8.1e-12 45.2 2.1 1.5 1 0 0 1 1 1 1 AP2 domain Spo12 PF05032.12 EEA05373.1 - 0.71 9.8 2.2 0.61 10.0 0.2 2.0 2 0 0 2 2 2 0 Spo12 family ABC1 PF03109.16 EEA05374.1 - 8.7e-22 77.5 0.0 2.8e-21 75.9 0.0 1.9 1 0 0 1 1 1 1 ABC1 family DUF4837 PF16125.5 EEA05374.1 - 0.048 12.7 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4837) Arm PF00514.23 EEA05375.1 - 2.9e-82 268.5 12.7 3.9e-11 42.6 0.0 10.2 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EEA05375.1 - 1.5e-21 76.4 0.1 0.00022 21.6 0.0 6.0 6 0 0 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 EEA05375.1 - 5.7e-18 65.1 0.0 0.0003 21.1 0.0 5.6 2 2 4 6 6 6 5 HEAT repeats HEAT PF02985.22 EEA05375.1 - 6.8e-17 60.1 0.5 0.029 14.6 0.0 8.2 9 0 0 9 9 8 3 HEAT repeat IBB PF01749.20 EEA05375.1 - 2.5e-16 59.9 0.8 2.6e-15 56.6 0.4 2.3 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 EEA05375.1 - 9.2e-16 57.1 0.1 3e-15 55.5 0.1 1.9 1 0 0 1 1 1 1 Atypical Arm repeat Adaptin_N PF01602.20 EEA05375.1 - 0.00059 18.5 0.0 0.057 12.0 0.0 2.8 2 2 1 3 3 3 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 EEA05375.1 - 0.00081 19.5 0.0 20 5.3 0.0 4.3 5 0 0 5 5 5 0 V-ATPase subunit H Cnd1 PF12717.7 EEA05375.1 - 0.0017 18.4 0.0 0.11 12.6 0.0 2.7 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 EEA05375.1 - 0.0024 17.4 0.1 1.1 8.6 0.1 2.6 2 1 0 2 2 2 2 Armadillo-like NopRA1 PF16201.5 EEA05375.1 - 0.0049 16.5 0.0 1.3 8.6 0.0 3.4 2 1 1 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Atx10homo_assoc PF09759.9 EEA05375.1 - 0.018 15.0 0.2 6.2 6.9 0.1 3.1 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Mo25 PF08569.11 EEA05375.1 - 0.12 11.7 0.0 0.53 9.6 0.0 1.9 2 1 0 2 2 2 0 Mo25-like ParcG PF10274.9 EEA05375.1 - 0.12 12.4 0.4 14 5.7 0.0 3.0 2 1 2 4 4 4 0 Parkin co-regulated protein DnaJ-X PF14308.6 EEA05376.1 - 1.6e-46 158.4 8.3 2.8e-46 157.6 8.3 1.4 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 EEA05376.1 - 4.5e-25 87.6 3.2 1.1e-24 86.4 3.2 1.7 1 0 0 1 1 1 1 DnaJ domain ATG_C PF09333.11 EEA05376.1 - 5.6e-05 23.4 0.6 0.00023 21.4 0.1 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain FHIPEP PF00771.20 EEA05376.1 - 0.14 10.6 4.8 0.34 9.3 0.8 2.1 2 0 0 2 2 2 0 FHIPEP family Med10 PF09748.9 EEA05377.1 - 1.9e-06 27.8 0.1 3e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Nab1 PF04902.12 EEA05377.1 - 0.0081 16.6 0.3 0.014 15.8 0.2 1.3 1 1 0 1 1 1 1 Conserved region in Nab1 BLOC1_2 PF10046.9 EEA05377.1 - 5.1 7.5 8.3 3 8.2 1.2 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PIP5K PF01504.18 EEA05378.1 - 9.8e-80 267.7 8.2 9.8e-80 267.7 8.2 2.1 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_6 PF13405.6 EEA05378.1 - 0.00058 19.6 2.9 0.0074 16.1 0.1 3.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EEA05378.1 - 0.0015 18.9 0.2 0.0078 16.6 0.2 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EEA05378.1 - 0.002 17.6 2.0 0.0053 16.2 0.2 2.7 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EEA05378.1 - 0.0059 16.4 0.6 0.056 13.3 0.4 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EEA05378.1 - 0.029 13.9 0.1 0.096 12.2 0.1 1.9 1 0 0 1 1 1 0 EF hand Methyltransf_31 PF13847.6 EEA05379.1 - 5.8e-13 48.9 0.0 8e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA05379.1 - 3.2e-12 46.9 0.0 6.5e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA05379.1 - 5.8e-12 46.2 0.0 1.3e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA05379.1 - 5.8e-11 43.0 0.0 1.1e-10 42.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA05379.1 - 5.5e-10 39.3 0.0 8.9e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA05379.1 - 2.5e-05 23.8 0.0 3.4e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EEA05379.1 - 0.00011 21.7 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Pox_MCEL PF03291.16 EEA05379.1 - 0.00026 20.2 0.0 0.00032 19.9 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_24 PF13578.6 EEA05379.1 - 0.025 15.6 0.0 0.053 14.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EEA05379.1 - 0.034 13.6 0.0 0.1 12.0 0.0 1.8 1 1 0 1 1 1 0 Putative methyltransferase MTS PF05175.14 EEA05379.1 - 0.082 12.4 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_8 PF05148.15 EEA05379.1 - 0.16 11.8 0.0 0.61 9.9 0.0 1.9 1 1 0 1 1 1 0 Hypothetical methyltransferase PrmA PF06325.13 EEA05379.1 - 0.21 10.9 0.0 0.29 10.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Kinesin PF00225.23 EEA05380.1 - 2.4e-92 309.4 2.1 4.3e-92 308.6 2.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EEA05380.1 - 5.4e-18 65.4 1.2 2.3e-17 63.3 0.3 2.4 2 0 0 2 2 2 1 Microtubule binding Costars PF14705.6 EEA05380.1 - 0.016 15.4 0.2 0.047 13.9 0.2 1.7 1 0 0 1 1 1 0 Costars DUF2973 PF11189.8 EEA05381.1 - 0.25 11.5 0.9 0.85 9.8 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) SBDS PF01172.18 EEA05382.1 - 1.3e-32 111.7 0.4 3.7e-32 110.3 0.1 1.9 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EEA05382.1 - 1.1e-26 93.1 0.0 2.4e-26 92.0 0.0 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain zf-AD PF07776.15 EEA05382.1 - 0.13 12.6 2.3 1.7 9.0 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) tRNA_synthFbeta PF17759.1 EEA05383.1 - 8e-30 103.9 0.0 1.2e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EEA05383.1 - 1.1e-29 102.4 0.2 2.9e-27 94.7 0.1 2.8 2 0 0 2 2 2 2 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EEA05383.1 - 5.8e-19 68.4 0.0 1.2e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EEA05383.1 - 1e-15 57.8 0.0 6.2e-10 39.2 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain eIF-1a PF01176.19 EEA05384.1 - 6.9e-24 83.4 0.0 1.2e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 PWI PF01480.17 EEA05385.1 - 3e-23 81.9 0.5 6.5e-23 80.8 0.5 1.6 1 0 0 1 1 1 1 PWI domain Glyc_hyd_38C_2 PF18230.1 EEA05385.1 - 0.067 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal sub-domain CBM_14 PF01607.24 EEA05386.1 - 0.028 14.6 43.9 0.45 10.7 0.1 9.0 6 1 3 9 9 9 0 Chitin binding Peritrophin-A domain CPW_WPC PF09717.10 EEA05386.1 - 0.15 13.0 0.1 0.15 13.0 0.1 8.9 8 3 0 8 8 8 0 Plasmodium falciparum domain of unknown function (CPW_WPC) MCM_bind PF09739.9 EEA05387.1 - 1.4e-53 182.3 5.9 5.3e-43 147.4 4.3 2.3 2 1 0 2 2 2 2 Mini-chromosome maintenance replisome factor RRM_1 PF00076.22 EEA05388.1 - 9.8e-26 89.4 0.1 9e-16 57.5 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EEA05388.1 - 0.038 14.0 0.1 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 EEA05388.1 - 0.043 13.8 0.2 0.34 10.9 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EEA05388.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 EEA05388.1 - 0.19 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif NUC173 PF08161.12 EEA05389.1 - 6.9e-30 104.2 0.9 1.4e-27 96.7 0.0 3.7 3 1 0 3 3 3 2 NUC173 domain RTP1_C1 PF10363.9 EEA05389.1 - 5.6e-05 23.3 5.0 0.00083 19.5 0.1 4.5 3 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Brix PF04427.18 EEA05390.1 - 1.4e-39 136.2 0.0 2.1e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain NIF PF03031.18 EEA05391.1 - 1.2e-28 99.9 0.0 1.8e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SUKH_6 PF14568.6 EEA05391.1 - 0.095 13.1 0.8 18 5.8 0.2 2.8 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall PTH2 PF01981.16 EEA05392.1 - 4.9e-17 62.3 0.1 5.7e-17 62.1 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 RFC1 PF08519.12 EEA05392.1 - 0.06 13.5 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain PrmA PF06325.13 EEA05393.1 - 5.5e-10 39.1 0.0 9e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EEA05393.1 - 1.6e-09 38.3 0.0 3.9e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA05393.1 - 1.3e-07 32.2 0.0 2.8e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA05393.1 - 8.6e-06 25.7 0.1 1.8e-05 24.6 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA05393.1 - 2.2e-05 24.3 0.0 5.3e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA05393.1 - 4.9e-05 22.9 0.0 9.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EEA05393.1 - 9.6e-05 22.4 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EEA05393.1 - 0.00023 20.2 0.0 0.00039 19.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EEA05393.1 - 0.0017 17.7 0.0 0.0045 16.3 0.0 1.6 1 1 1 2 2 2 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 EEA05393.1 - 0.0032 17.3 0.0 0.0067 16.3 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 EEA05393.1 - 0.0061 16.3 0.2 0.023 14.4 0.0 1.8 2 0 0 2 2 2 1 Met-10+ like-protein TehB PF03848.14 EEA05393.1 - 0.01 15.3 0.4 0.028 13.8 0.0 1.9 2 0 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 EEA05393.1 - 0.018 15.7 0.0 0.055 14.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EEA05393.1 - 0.029 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EEA05393.1 - 0.04 13.6 0.0 0.088 12.4 0.0 1.5 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 EEA05393.1 - 0.05 13.3 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Lysine methyltransferase DUF3458_C PF17432.2 EEA05394.1 - 4.2e-71 239.9 0.0 5.5e-71 239.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 EEA05394.1 - 5.8e-47 160.1 1.7 9.6e-47 159.4 1.7 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 EEA05394.1 - 6.5e-22 77.8 0.0 1.3e-21 76.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 EEA05394.1 - 3.2e-07 30.7 0.0 6.3e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Leptin PF02024.15 EEA05394.1 - 0.072 12.9 1.0 0.22 11.3 0.4 2.2 2 0 0 2 2 2 0 Leptin DUF3458_C PF17432.2 EEA05395.1 - 5.6e-68 229.7 0.0 7.3e-68 229.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 EEA05395.1 - 1e-45 156.0 0.2 1.6e-45 155.3 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain DUF3458 PF11940.8 EEA05395.1 - 3.2e-26 91.6 0.2 8.4e-26 90.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3458) Ig-like fold Peptidase_M1_N PF17900.1 EEA05395.1 - 1.1e-09 38.8 0.0 2e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain YL1 PF05764.13 EEA05396.1 - 2.4e-29 103.2 36.5 2.4e-29 103.2 36.5 2.2 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 EEA05396.1 - 2.2e-11 43.3 1.2 1.8e-10 40.4 0.1 2.3 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain PAN_4 PF14295.6 EEA05398.1 - 3.6e-05 23.6 18.3 0.00012 21.9 0.2 4.1 3 2 0 3 3 3 2 PAN domain PAN_1 PF00024.26 EEA05398.1 - 0.0019 18.1 5.4 0.0019 18.1 5.4 3.5 2 2 1 3 3 3 2 PAN domain TSP_1 PF00090.19 EEA05398.1 - 0.0049 17.0 4.6 0.0049 17.0 4.6 5.3 4 2 2 6 6 6 3 Thrombospondin type 1 domain ThiF PF00899.21 EEA05399.1 - 5.6e-10 39.0 0.0 1.6e-09 37.5 0.0 1.7 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EEA05399.1 - 0.083 13.1 0.0 22 5.3 0.0 2.7 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 four-helix bundle Anticodon_1 PF08264.13 EEA05399.1 - 0.56 10.2 4.1 11 6.0 0.5 2.7 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA RNA_pol_Rpb2_6 PF00562.28 EEA05400.1 - 3e-123 411.8 0.0 4.5e-123 411.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EEA05400.1 - 9.8e-48 162.3 0.4 1.7e-47 161.6 0.4 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EEA05400.1 - 7.2e-33 112.8 0.1 1.9e-32 111.5 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EEA05400.1 - 1.3e-25 89.5 0.0 2.7e-25 88.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EEA05400.1 - 5.3e-20 71.4 0.0 1.2e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EEA05400.1 - 7e-20 71.5 2.6 4.1e-12 46.1 0.4 2.4 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 EEA05400.1 - 7.5e-09 36.0 1.7 7.5e-09 36.0 1.7 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 DEAD PF00270.29 EEA05402.1 - 1e-35 123.1 0.0 2.7e-35 121.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA05402.1 - 8.8e-25 87.2 0.0 3.3e-24 85.4 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EEA05402.1 - 4.5e-05 23.7 0.4 0.0058 16.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain ERCC3_RAD25_C PF16203.5 EEA05402.1 - 0.002 17.4 0.7 0.005 16.1 0.0 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 EEA05402.1 - 0.016 14.6 2.2 0.086 12.2 0.0 2.9 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit GpcrRhopsn4 PF10192.9 EEA05403.1 - 0.041 13.3 5.5 0.055 12.9 5.5 1.0 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain 7tm_3 PF00003.22 EEA05403.1 - 0.089 12.5 6.0 0.12 12.1 6.0 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR TMEM174 PF15029.6 EEA05403.1 - 0.25 11.0 1.4 0.32 10.7 1.4 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 SLATT_5 PF18160.1 EEA05403.1 - 0.28 10.5 5.8 0.34 10.2 5.8 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF3953 PF13129.6 EEA05403.1 - 0.32 10.8 5.9 1.3 8.8 5.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3953) DUF2207 PF09972.9 EEA05403.1 - 1.1 8.0 3.6 1.2 7.8 3.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FlaC_arch PF05377.11 EEA05404.1 - 3.2 8.2 8.6 0.69 10.3 0.2 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) TBP PF00352.21 EEA05405.1 - 8.7e-26 89.7 0.2 2.2e-12 46.7 0.0 2.4 2 1 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) Transposase_28 PF04195.12 EEA05405.1 - 0.16 12.2 0.0 17 5.7 0.0 2.3 2 0 0 2 2 2 0 Putative gypsy type transposon UQ_con PF00179.26 EEA05406.1 - 2.2e-28 98.6 0.1 3e-28 98.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA05406.1 - 0.034 14.4 0.1 0.04 14.2 0.1 1.4 1 0 0 1 1 1 0 RWD domain UCH PF00443.29 EEA05407.1 - 3.2e-33 115.3 9.9 3.2e-33 115.3 9.9 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA05407.1 - 2.3e-09 37.3 24.3 9.2e-09 35.3 8.2 3.5 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUF5504 PF17608.2 EEA05407.1 - 0.49 10.5 4.2 2.1 8.5 0.0 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5504) DUF2318 PF10080.9 EEA05408.1 - 0.0013 18.8 0.4 0.0023 18.0 0.4 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) ECR1_N PF14382.6 EEA05408.1 - 0.0028 17.4 2.6 0.0031 17.3 0.1 2.2 3 0 0 3 3 3 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 EEA05408.1 - 0.0046 17.5 0.2 0.071 13.7 0.0 2.2 1 1 1 2 2 2 1 Exosome component EXOSC1/CSL4 MOZ_SAS PF01853.18 EEA05410.1 - 5.3e-67 224.9 3.4 2.2e-63 213.2 0.7 2.7 3 0 0 3 3 3 2 MOZ/SAS family zf-MYST PF17772.1 EEA05410.1 - 1.2e-21 76.1 2.6 3e-21 74.8 2.6 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EEA05410.1 - 2.6e-10 40.0 1.0 6.7e-10 38.7 1.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EEA05410.1 - 0.00017 21.9 0.0 0.00038 20.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA05410.1 - 0.0093 15.9 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA05410.1 - 0.034 14.4 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family zf-C2H2 PF00096.26 EEA05410.1 - 0.19 12.2 0.7 0.49 10.9 0.7 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type Crust_neurohorm PF01147.17 EEA05410.1 - 3.2 7.6 5.4 3.1 7.7 2.6 2.2 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family MS_channel PF00924.18 EEA05412.1 - 1.8e-16 60.3 0.5 3.8e-16 59.3 0.5 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel Fumble PF03630.14 EEA05413.1 - 2.1e-30 106.1 3.1 3.3e-30 105.4 3.1 1.3 1 0 0 1 1 1 1 Fumble SNAPc_SNAP43 PF09808.9 EEA05414.1 - 8.8e-12 45.4 0.3 2.6e-10 40.6 0.3 2.5 1 1 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Metallophos PF00149.28 EEA05415.1 - 7.7e-09 36.3 1.1 1.5e-08 35.4 1.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase VMA21 PF09446.10 EEA05416.1 - 5.4e-11 42.4 10.1 6.7e-11 42.1 10.1 1.1 1 0 0 1 1 1 1 VMA21-like domain SLAC1 PF03595.17 EEA05416.1 - 0.0075 15.6 0.6 0.0089 15.3 0.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel SCIMP PF15050.6 EEA05416.1 - 0.057 13.9 0.1 0.077 13.5 0.1 1.2 1 0 0 1 1 1 0 SCIMP protein RNA_pol_A_bac PF01000.26 EEA05417.1 - 4.6e-25 88.2 0.2 2.6e-24 85.8 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EEA05417.1 - 2.2e-21 75.0 0.0 3.1e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 EEA05417.1 - 0.00039 20.5 0.8 0.00039 20.5 0.8 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EEA05417.1 - 0.0054 17.3 1.3 0.0054 17.3 1.3 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EEA05417.1 - 0.0068 16.5 0.7 0.0068 16.5 0.7 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain ETF_QO PF05187.13 EEA05417.1 - 0.16 12.1 5.0 0.17 12.0 0.5 2.3 2 0 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4 PF00037.27 EEA05417.1 - 5.5 7.0 8.3 2.2 8.3 0.6 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain SWIM PF04434.17 EEA05418.1 - 0.01 15.5 0.9 0.031 13.9 0.9 1.8 1 0 0 1 1 1 0 SWIM zinc finger MSA-2c PF12238.8 EEA05418.1 - 0.011 15.8 0.5 0.022 14.8 0.5 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Herpes_UL37_2 PF07413.11 EEA05418.1 - 0.034 13.4 1.3 0.083 12.1 0.2 1.9 1 1 0 2 2 2 0 Betaherpesvirus immediate-early glycoprotein UL37 RNase_PH PF01138.21 EEA05421.1 - 6.7e-16 59.0 0.0 1.1e-15 58.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EEA05421.1 - 0.00028 20.8 0.0 0.0005 20.0 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 tRNA-synt_2 PF00152.20 EEA05422.1 - 1.9e-76 257.1 0.0 2.6e-75 253.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA05422.1 - 1.6e-07 31.2 0.3 3.9e-07 30.0 0.3 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EEA05422.1 - 0.0012 18.4 0.0 0.0058 16.1 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) MAAL_N PF05034.13 EEA05422.1 - 0.22 11.1 0.2 0.92 9.1 0.1 2.1 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase N-terminus vATP-synt_E PF01991.18 EEA05423.1 - 6.1e-53 179.2 5.4 7.2e-53 179.0 5.4 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Par3_HAL_N_term PF12053.8 EEA05423.1 - 0.016 15.4 0.0 0.049 13.8 0.0 1.8 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins DUF1804 PF08822.11 EEA05423.1 - 0.099 12.6 3.7 0.15 12.0 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) MutS_V PF00488.21 EEA05424.1 - 3.6e-73 245.6 1.1 6.4e-73 244.8 0.3 1.8 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EEA05424.1 - 1.2e-31 110.4 0.3 6.3e-31 108.1 0.0 2.3 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EEA05424.1 - 1.3e-31 109.1 0.0 5.9e-31 107.0 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EEA05424.1 - 6.1e-06 26.6 0.0 2e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 MutS domain II Fanconi_A PF03511.14 EEA05424.1 - 0.97 9.4 2.9 47 4.0 0.0 3.5 4 0 0 4 4 4 0 Fanconi anaemia group A protein DAO PF01266.24 EEA05425.1 - 2e-15 57.2 0.0 3e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.15 EEA05425.1 - 1.3e-14 53.7 0.0 2.1e-14 53.0 0.0 1.3 1 1 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) NAD_binding_8 PF13450.6 EEA05425.1 - 0.007 16.6 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA05425.1 - 0.039 13.2 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EEA05425.1 - 0.082 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Thi4 family DUF1837 PF08878.11 EEA05425.1 - 0.098 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1837) NAD_binding_9 PF13454.6 EEA05425.1 - 0.11 12.4 0.0 1.3 9.0 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding IPP-2 PF04979.14 EEA05426.1 - 5.2e-17 62.8 1.0 8.1e-17 62.2 1.0 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Cornichon PF03311.14 EEA05426.1 - 0.15 12.4 0.0 0.23 11.8 0.0 1.2 1 0 0 1 1 1 0 Cornichon protein Ribosomal_L6 PF00347.23 EEA05427.1 - 9.7e-29 99.9 1.4 3.7e-15 56.4 0.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF4351 PF14261.6 EEA05429.1 - 0.15 12.2 5.9 15 5.7 0.1 4.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4351) Cob_adeno_trans PF01923.18 EEA05429.1 - 5.3 7.1 10.0 0.92 9.6 0.9 3.6 2 1 1 3 3 3 0 Cobalamin adenosyltransferase Ribosomal_L7Ae PF01248.26 EEA05430.1 - 7.4e-21 73.7 0.8 1.3e-20 72.9 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L5e PF17144.4 EEA05431.1 - 7.6e-82 273.1 0.1 1.5e-81 272.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EEA05431.1 - 3.4e-32 111.2 5.2 3.4e-32 111.2 5.2 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 EEA05431.1 - 0.0038 17.6 0.8 0.025 15.0 0.0 2.3 2 0 0 2 2 2 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast ATP_sub_h PF10775.9 EEA05431.1 - 0.054 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 ATP synthase complex subunit h DUF1476 PF07345.11 EEA05431.1 - 0.063 13.6 0.1 0.27 11.6 0.0 2.0 1 1 1 2 2 2 0 ATPase inhibitor subunit zeta DnaJ PF00226.31 EEA05432.1 - 7.1e-14 51.7 0.5 7.1e-14 51.7 0.5 2.2 3 0 0 3 3 3 1 DnaJ domain FlgM PF04316.13 EEA05432.1 - 0.16 12.4 2.7 1.1 9.7 0.2 2.9 2 1 0 2 2 2 0 Anti-sigma-28 factor, FlgM GP3_package PF16677.5 EEA05432.1 - 0.24 11.6 5.5 5.6 7.1 3.7 2.9 2 1 1 3 3 3 0 DNA-packaging protein gp3 Beta-Casp PF10996.8 EEA05433.1 - 2.6e-29 101.7 0.0 5.3e-29 100.7 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EEA05433.1 - 1.6e-16 60.3 0.0 5.3e-16 58.6 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EEA05433.1 - 1.2e-15 57.1 0.0 2.6e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EEA05433.1 - 1.4e-14 54.5 0.0 4e-14 53.1 0.0 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily CPSF73-100_C PF11718.8 EEA05433.1 - 6.3e-12 45.5 0.0 1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta_lactamase3 PF17030.5 EEA05433.1 - 1.4e-07 31.0 0.0 3.3e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Putative beta-lactamase-like family Lactamase_B_2 PF12706.7 EEA05433.1 - 0.0011 18.6 0.1 0.0066 16.0 0.1 2.3 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EEA05433.1 - 0.0012 18.8 0.0 0.0086 16.0 0.0 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Baculo_Y142 PF04913.12 EEA05433.1 - 0.039 12.6 0.0 0.067 11.9 0.0 1.3 1 0 0 1 1 1 0 Baculovirus Y142 protein Hist_deacetyl PF00850.19 EEA05434.1 - 3.1e-64 217.4 0.0 5.2e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Ank_4 PF13637.6 EEA05434.1 - 3.9e-10 40.1 1.7 0.0028 18.2 0.1 3.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA05434.1 - 1.3e-09 38.5 0.1 8.3e-07 29.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA05434.1 - 2.3e-08 33.6 0.2 0.39 11.4 0.1 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EEA05434.1 - 4.6e-08 33.2 0.2 8.5e-06 26.0 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EEA05434.1 - 2.8e-05 24.4 3.2 0.17 12.4 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat SIR2_2 PF13289.6 EEA05434.1 - 0.028 14.5 0.0 0.072 13.2 0.0 1.7 1 0 0 1 1 1 0 SIR2-like domain SAS-6_N PF16531.5 EEA05435.1 - 1e-13 51.7 3.1 1e-13 51.7 3.1 3.0 2 1 0 2 2 2 1 Centriolar protein SAS N-terminal EF-hand_8 PF13833.6 EEA05436.1 - 5.5e-10 39.0 0.5 5.1e-07 29.4 0.1 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA05436.1 - 6.7e-08 31.9 2.1 0.02 14.8 0.0 4.0 4 1 1 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 EEA05436.1 - 1e-07 32.3 0.3 9.8e-07 29.1 0.1 2.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 EEA05436.1 - 1.8e-07 30.2 0.2 0.021 14.4 0.0 3.6 3 1 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 EEA05436.1 - 0.0029 17.9 0.4 0.007 16.7 0.2 1.7 2 0 0 2 2 2 1 EF-hand domain DUF5475 PF17569.2 EEA05436.1 - 0.035 14.4 0.0 0.081 13.2 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5475) Ten1_2 PF15490.6 EEA05437.1 - 7.7e-13 48.2 0.2 9.3e-13 47.9 0.2 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit tRNA_anti-codon PF01336.25 EEA05437.1 - 0.03 14.3 0.3 0.058 13.4 0.3 1.5 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain RMI2 PF16100.5 EEA05437.1 - 0.048 13.5 0.0 0.053 13.4 0.0 1.1 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 PseudoU_synth_1 PF01416.20 EEA05438.1 - 2.5e-16 60.0 0.0 1.1e-12 48.3 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 EEA05438.1 - 0.0062 16.4 3.1 0.18 11.6 1.0 2.4 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2344) DUF2151 PF10221.9 EEA05439.1 - 0.51 8.9 21.0 0.65 8.5 21.0 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Hid1 PF12722.7 EEA05439.1 - 1.7 6.7 20.5 2.1 6.4 20.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 EEA05439.1 - 1.7 7.0 6.9 2.2 6.6 6.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EF-hand_7 PF13499.6 EEA05440.1 - 0.26 11.7 2.5 0.69 10.4 0.9 2.4 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EEA05440.1 - 9.7 6.0 8.1 15 5.4 0.0 4.0 5 0 0 5 5 5 0 EF hand TMEM239 PF15841.5 EEA05441.1 - 1.5 8.7 8.7 0.37 10.7 5.1 1.7 1 1 1 2 2 2 0 Transmembrane protein 239 family L_biotic_typeA PF04604.13 EEA05443.1 - 0.28 11.0 1.7 0.92 9.4 0.0 2.5 2 0 0 2 2 2 0 Type-A lantibiotic zf-C2HE PF16278.5 EEA05443.1 - 0.39 11.2 4.8 5.8 7.5 0.5 3.3 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger RPN1_RPN2_N PF17781.1 EEA05445.1 - 8.4e-74 248.7 5.7 1.7e-73 247.7 5.7 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EEA05445.1 - 2.8e-18 65.7 0.6 1.3e-17 63.5 0.1 2.3 2 0 0 2 2 2 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EEA05445.1 - 5.9e-15 54.9 10.4 2.6e-06 27.6 0.6 6.8 6 0 0 6 6 6 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EEA05445.1 - 3.7e-08 33.7 0.1 0.014 15.7 0.1 4.7 5 0 0 5 5 5 2 HEAT repeats Utp13 PF08625.11 EEA05445.1 - 0.062 13.2 0.4 1.6 8.7 0.1 2.8 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain DUF5071 PF16804.5 EEA05445.1 - 0.065 13.5 0.1 0.69 10.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5071) HEAT PF02985.22 EEA05445.1 - 0.1 12.9 0.1 12 6.5 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat UQ_con PF00179.26 EEA05446.1 - 3.5e-17 62.4 0.0 3.6e-17 62.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA05446.1 - 0.0049 17.2 0.0 0.0049 17.1 0.0 1.2 1 0 0 1 1 1 1 RWD domain Hydrolase_4 PF12146.8 EEA05447.1 - 2.4e-15 56.5 0.0 5.5e-15 55.3 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA05447.1 - 9.5e-14 52.5 0.0 1.1e-13 52.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA05447.1 - 9.7e-13 48.3 0.3 2.6e-11 43.7 0.3 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 EEA05447.1 - 0.00023 20.9 0.0 0.0004 20.1 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Asp2 PF16929.5 EEA05447.1 - 0.0095 15.0 0.0 0.02 13.9 0.0 1.5 2 0 0 2 2 2 1 Accessory Sec system GspB-transporter UPF0227 PF05728.12 EEA05447.1 - 0.014 15.4 0.0 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) DUF2920 PF11144.8 EEA05447.1 - 0.042 13.0 0.0 0.99 8.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2920) AXE1 PF05448.12 EEA05447.1 - 0.045 12.4 0.0 1.6 7.3 0.0 2.7 3 0 0 3 3 3 0 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 EEA05447.1 - 0.061 12.8 0.0 2.3 7.7 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Patatin PF01734.22 EEA05447.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Patatin-like phospholipase Hydrolase_4 PF12146.8 EEA05448.1 - 5.8e-19 68.3 0.0 8.5e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA05448.1 - 1.5e-13 51.0 0.0 2.7e-12 46.9 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA05448.1 - 2.4e-09 38.1 0.0 3.2e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EEA05448.1 - 0.0017 18.3 0.0 0.011 15.7 0.0 2.2 2 1 1 3 3 3 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EEA05448.1 - 0.02 14.4 0.0 0.2 11.2 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Ndr PF03096.14 EEA05448.1 - 0.021 13.6 0.0 0.039 12.7 0.0 1.4 1 0 0 1 1 1 0 Ndr family Esterase PF00756.20 EEA05448.1 - 0.21 11.2 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase RFC1 PF08519.12 EEA05449.1 - 4.5e-37 127.6 0.1 4.5e-37 127.6 0.1 2.9 3 0 0 3 3 3 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EEA05449.1 - 3.2e-14 53.1 0.6 4.5e-13 49.4 0.0 3.1 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EEA05449.1 - 7.9e-12 45.7 5.6 3.6e-11 43.6 0.0 3.6 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EEA05449.1 - 1.5e-09 37.9 0.5 1.5e-09 37.9 0.5 2.4 2 0 0 2 2 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EEA05449.1 - 2.1e-06 27.8 0.2 0.0029 17.5 0.0 3.2 2 0 0 2 2 2 2 Rad17 P-loop domain PTCB-BRCT PF12738.7 EEA05449.1 - 6.5e-05 22.8 0.0 0.00017 21.5 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.12 EEA05449.1 - 0.00017 21.4 0.0 0.00056 19.7 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA05449.1 - 0.0011 19.4 0.0 0.007 16.8 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EEA05449.1 - 0.0011 19.3 0.1 0.0079 16.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EEA05449.1 - 0.0028 18.2 0.0 0.0028 18.2 0.0 2.9 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EEA05449.1 - 0.0054 16.9 0.0 0.024 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA05449.1 - 0.0054 16.7 0.0 0.084 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EEA05449.1 - 0.01 15.5 0.3 0.029 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EEA05449.1 - 0.036 13.8 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EEA05449.1 - 0.046 13.8 2.4 0.11 12.5 0.0 3.0 3 1 1 4 4 4 0 AAA domain AAA_assoc_2 PF16193.5 EEA05449.1 - 0.051 13.9 0.1 0.2 12.0 0.1 2.1 1 0 0 1 1 1 0 AAA C-terminal domain NTPase_1 PF03266.15 EEA05449.1 - 0.06 13.3 0.1 0.2 11.5 0.1 2.0 1 1 0 1 1 1 0 NTPase AAA_28 PF13521.6 EEA05449.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA05449.1 - 0.077 13.3 0.8 0.3 11.4 0.2 2.3 2 1 0 2 2 1 0 AAA domain T2SSE PF00437.20 EEA05449.1 - 0.091 11.8 0.1 0.5 9.4 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein Proteasom_PSMB PF10508.9 EEA05451.1 - 1.2e-23 83.4 1.8 8e-23 80.7 1.8 1.9 1 1 0 1 1 1 1 Proteasome non-ATPase 26S subunit Mcl1_mid PF12341.8 EEA05452.1 - 4.6e-47 160.8 0.1 1.1e-44 152.9 0.0 2.9 2 1 0 3 3 3 2 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 EEA05452.1 - 0.053 13.8 0.0 4.7 7.6 0.0 3.6 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Hrs_helical PF12210.8 EEA05453.1 - 0.31 11.6 0.1 0.31 11.6 0.1 2.3 2 1 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate AKNA PF12443.8 EEA05454.1 - 0.075 13.7 1.4 0.26 11.9 0.3 2.4 2 1 0 2 2 2 0 AT-hook-containing transcription factor Myosin_head PF00063.21 EEA05455.1 - 2.7e-166 554.7 15.6 8.6e-166 553.0 15.6 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Zeta_toxin PF06414.12 EEA05455.1 - 0.088 12.1 0.0 0.23 10.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 EEA05455.1 - 0.096 13.0 0.0 0.5 10.6 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_lid_6 PF17866.1 EEA05455.1 - 0.096 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA lid domain Hpr_kinase_C PF07475.12 EEA05455.1 - 0.098 12.2 3.1 6.1 6.3 0.0 3.1 4 0 0 4 4 4 0 HPr Serine kinase C-terminal domain PUB PF09409.10 EEA05455.1 - 9.4 6.2 8.2 3.6 7.6 2.9 3.1 3 0 0 3 3 3 0 PUB domain Ribosomal_L23 PF00276.20 EEA05456.1 - 5.1e-17 62.0 2.1 5.1e-17 62.0 2.1 2.3 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EEA05456.1 - 3.2e-08 33.7 5.3 3.2e-08 33.7 5.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Cas_APE2256 PF09651.10 EEA05457.1 - 0.014 15.3 0.2 0.042 13.7 0.1 1.8 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_APE2256) CENP-Q PF13094.6 EEA05457.1 - 0.043 14.0 4.0 0.049 13.8 4.0 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF3828 PF12883.7 EEA05457.1 - 0.087 13.2 1.1 0.22 11.9 1.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3828) RapA_C PF12137.8 EEA05457.1 - 0.22 10.5 3.6 0.28 10.1 3.6 1.0 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal MOLO1 PF17175.4 EEA05458.1 - 7.5e-13 48.6 0.1 1.9e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 EEA05458.1 - 2.7e-08 34.0 0.0 1.6e-07 31.5 0.0 2.1 1 1 0 1 1 1 1 TPM domain Prefoldin PF02996.17 EEA05459.1 - 1.1e-17 64.1 0.8 1.1e-17 64.1 0.8 1.9 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.6 EEA05459.1 - 0.0082 16.2 0.4 0.54 10.3 0.1 2.5 2 1 0 2 2 2 1 Prefoldin subunit UPF0147 PF03685.13 EEA05459.1 - 0.17 12.0 1.5 7 6.8 0.1 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0147) Tropomyosin PF00261.20 EEA05459.1 - 0.46 9.8 7.0 0.091 12.1 1.1 2.2 2 0 0 2 2 2 0 Tropomyosin TPR_MLP1_2 PF07926.12 EEA05459.1 - 1.8 8.7 8.4 3 7.9 0.4 3.3 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Med21 PF11221.8 EEA05459.1 - 7 6.9 9.0 2.7 8.3 0.4 3.0 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Pkinase PF00069.25 EEA05460.1 - 1.3e-62 211.6 0.0 2.6e-62 210.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 EEA05460.1 - 3.5e-54 180.8 1.8 1.6e-18 66.5 0.0 5.1 4 1 0 4 4 4 4 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 EEA05460.1 - 9.8e-29 100.4 0.0 1.7e-28 99.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA05460.1 - 4.2e-08 32.8 0.0 1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EEA05460.1 - 0.0065 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EEA05460.1 - 0.04 13.0 0.0 0.1 11.6 0.0 1.6 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EEA05460.1 - 0.1 11.5 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Sod_Fe_C PF02777.18 EEA05461.1 - 0.1 12.8 0.0 0.44 10.8 0.0 2.0 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, C-terminal domain Usher PF00577.20 EEA05462.1 - 0.039 12.8 1.2 0.064 12.1 1.2 1.3 1 0 0 1 1 1 0 Outer membrane usher protein PKcGMP_CC PF16808.5 EEA05462.1 - 3.8 7.4 30.2 0.032 14.1 4.0 4.8 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1192 PF06698.11 EEA05462.1 - 4.2 7.5 8.3 1.7 8.7 0.2 3.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) zf_CCCH_4 PF18345.1 EEA05463.1 - 0.00016 21.6 15.9 0.0081 16.2 0.7 3.8 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 EEA05463.1 - 0.0014 18.5 1.2 0.0014 18.5 1.2 4.8 5 1 0 5 5 5 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EEA05463.1 - 0.012 16.1 25.0 0.093 13.2 4.6 4.0 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger tRNA-synt_1c PF00749.21 EEA05464.1 - 1.6e-108 362.3 0.0 2e-108 362.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EEA05464.1 - 1.4e-34 119.5 0.0 3.1e-34 118.4 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 EEA05464.1 - 0.1 11.9 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DEAD PF00270.29 EEA05465.1 - 1.8e-43 148.4 0.0 6.7e-43 146.5 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA05465.1 - 1.4e-21 76.9 3.0 4.1e-21 75.4 0.0 3.4 4 0 0 4 4 4 1 Helicase conserved C-terminal domain AP2 PF00847.20 EEA05466.1 - 2.5e-11 43.6 3.3 4.8e-11 42.7 3.3 1.5 1 0 0 1 1 1 1 AP2 domain DUF2040 PF09745.9 EEA05468.1 - 8.2e-13 48.5 7.6 8.2e-13 48.5 7.6 2.3 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) DUF3896 PF13035.6 EEA05468.1 - 0.38 10.9 0.2 0.38 10.9 0.2 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3896) AAA PF00004.29 EEA05469.1 - 6.6e-42 143.1 0.0 1.2e-41 142.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA05469.1 - 4e-12 45.7 0.1 8.2e-12 44.7 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EEA05469.1 - 3.3e-10 39.8 0.1 8.4e-10 38.5 0.1 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EEA05469.1 - 8.2e-08 32.8 0.1 9e-05 22.9 0.1 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 EEA05469.1 - 2.4e-06 27.8 0.0 9.2e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA05469.1 - 6e-06 26.3 0.1 8.2e-05 22.6 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EEA05469.1 - 2.9e-05 23.9 0.0 6.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA05469.1 - 9e-05 22.8 0.2 0.022 15.0 0.0 2.9 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EEA05469.1 - 0.0012 18.6 0.0 0.0027 17.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EEA05469.1 - 0.0013 19.2 0.1 0.0082 16.7 0.0 2.4 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.13 EEA05469.1 - 0.0014 17.9 0.0 0.0029 16.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 EEA05469.1 - 0.0018 18.7 0.0 0.0039 17.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Sigma54_activat PF00158.26 EEA05469.1 - 0.0023 17.6 0.0 0.0075 16.0 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 EEA05469.1 - 0.0024 17.4 0.0 0.0055 16.2 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EEA05469.1 - 0.0031 16.9 0.1 0.0062 15.9 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 EEA05469.1 - 0.0045 16.8 0.5 0.18 11.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA05469.1 - 0.0084 15.8 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EEA05469.1 - 0.0085 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EEA05469.1 - 0.0096 15.9 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EEA05469.1 - 0.01 15.0 0.0 0.021 14.0 0.0 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF815) Thymidylate_kin PF02223.17 EEA05469.1 - 0.012 15.3 0.2 1.3 8.7 0.2 2.4 2 0 0 2 2 2 0 Thymidylate kinase ATPase PF06745.13 EEA05469.1 - 0.016 14.6 0.4 0.094 12.0 0.0 2.3 3 0 0 3 3 3 0 KaiC PhoH PF02562.16 EEA05469.1 - 0.017 14.6 0.1 0.032 13.7 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EEA05469.1 - 0.018 15.3 0.1 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA05469.1 - 0.02 14.5 0.2 0.048 13.2 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA05469.1 - 0.026 14.7 0.0 0.071 13.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain Parvo_NS1 PF01057.17 EEA05469.1 - 0.034 13.2 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 EEA05469.1 - 0.035 14.1 0.0 0.077 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA05469.1 - 0.083 12.8 0.1 0.54 10.1 0.0 2.3 1 1 0 2 2 2 0 NACHT domain Prot_ATP_OB_N PF17758.1 EEA05469.1 - 0.091 12.4 0.1 0.27 10.9 0.0 1.8 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain Zeta_toxin PF06414.12 EEA05469.1 - 0.092 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 EEA05469.1 - 0.18 11.5 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Coatomer_WDAD PF04053.14 EEA05471.1 - 3.9e-56 191.0 14.7 4.6e-51 174.3 4.1 3.0 3 1 0 3 3 3 2 Coatomer WD associated region COPI_C PF06957.11 EEA05471.1 - 5.1e-53 180.3 0.1 8.7e-53 179.5 0.1 1.4 1 1 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EEA05471.1 - 6.8e-43 143.8 23.7 3.1e-07 31.0 1.2 9.3 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA05471.1 - 5.4e-10 39.4 0.2 0.00068 19.9 0.0 5.1 3 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TF_Zn_Ribbon PF08271.12 EEA05471.1 - 0.46 10.0 2.6 1.2 8.8 2.6 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EEA05471.1 - 1 8.9 3.8 4.1 7.0 3.8 2.1 1 1 0 1 1 1 0 zinc-ribbon domain DNA_pol_E_B PF04042.16 EEA05472.1 - 6.1e-32 110.7 1.4 9.9e-32 110.0 1.4 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Peptidase_Mx PF15887.5 EEA05472.1 - 0.091 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase TFIIB PF00382.19 EEA05473.1 - 1.3e-12 47.6 0.6 3.7e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EEA05473.1 - 5.1e-10 38.7 1.5 1.1e-09 37.6 1.5 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Nod1 PF17114.5 EEA05473.1 - 0.04 14.1 0.6 0.13 12.4 0.6 1.8 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 cobW PF02492.19 EEA05474.1 - 1.7e-40 138.5 6.0 1.1e-39 135.9 6.0 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EEA05474.1 - 2.7e-05 24.0 0.0 4.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain NACHT PF05729.12 EEA05474.1 - 0.0021 18.0 0.4 0.0076 16.2 0.0 1.9 2 0 0 2 2 2 1 NACHT domain T2SSE PF00437.20 EEA05474.1 - 0.0027 16.8 1.8 0.0031 16.6 0.2 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 EEA05474.1 - 0.0028 17.4 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EEA05474.1 - 0.0054 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EEA05474.1 - 0.0063 16.4 1.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EEA05474.1 - 0.01 16.2 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 EEA05474.1 - 0.011 15.8 2.8 0.018 15.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EEA05474.1 - 0.014 15.4 0.1 0.03 14.3 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EEA05474.1 - 0.016 14.9 0.1 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA05474.1 - 0.027 14.0 1.3 0.71 9.4 0.1 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region MobB PF03205.14 EEA05474.1 - 0.027 14.4 0.2 0.073 13.0 0.2 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.6 EEA05474.1 - 0.039 14.3 0.3 0.097 13.0 0.3 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA05474.1 - 0.04 14.5 0.0 0.12 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EEA05474.1 - 0.056 12.4 0.1 8.7 5.2 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EEA05474.1 - 0.074 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 EEA05474.1 - 0.09 11.7 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 EEA05474.1 - 0.14 12.1 2.7 0.17 11.8 1.1 2.0 2 0 0 2 2 2 0 NTPase RsgA_GTPase PF03193.16 EEA05474.1 - 0.65 9.9 4.9 12 5.7 0.1 2.7 2 1 1 3 3 3 0 RsgA GTPase T3SchapCesA PF11439.8 EEA05474.1 - 1.1 9.4 6.8 14 5.9 0.0 3.7 2 1 2 4 4 4 0 Type III secretion system filament chaperone CesA AAA_23 PF13476.6 EEA05474.1 - 1.9 9.0 10.8 3.4 8.1 8.7 2.3 2 1 0 2 2 2 0 AAA domain U3_assoc_6 PF08640.11 EEA05475.1 - 1.8e-25 88.8 2.3 8.8e-25 86.6 0.9 2.8 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_19 PF14559.6 EEA05475.1 - 0.0078 16.7 0.0 0.41 11.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA05475.1 - 0.034 15.0 0.1 6.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP-synt_J PF04911.12 EEA05475.1 - 0.084 12.5 2.3 3.3 7.3 0.8 2.5 2 0 0 2 2 2 0 ATP synthase j chain Pep3_Vps18 PF05131.14 EEA05476.1 - 5.6e-08 32.7 1.6 3.3e-07 30.2 1.6 2.2 1 1 0 1 1 1 1 Pep3/Vps18/deep orange family zf-RING_11 PF17123.5 EEA05476.1 - 0.0044 16.7 1.5 0.0044 16.7 1.5 2.9 2 0 0 2 2 2 1 RING-like zinc finger DUF4562 PF15123.6 EEA05476.1 - 0.16 11.9 0.1 0.37 10.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4562) zf-RING_2 PF13639.6 EEA05476.1 - 4.3 7.8 10.8 0.64 10.4 0.1 3.6 3 0 0 3 3 3 0 Ring finger domain UDPG_MGDP_dh_N PF03721.14 EEA05477.1 - 2.1e-52 177.4 0.0 6.6e-52 175.8 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EEA05477.1 - 3.4e-29 100.9 0.0 9.6e-29 99.4 0.0 1.8 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EEA05477.1 - 1.1e-28 99.7 0.0 4.8e-26 91.2 0.0 2.8 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 EEA05477.1 - 0.063 13.5 0.0 0.26 11.4 0.0 2.1 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EEA05477.1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain zf-rbx1 PF12678.7 EEA05478.1 - 2.8e-25 88.4 13.3 4.3e-25 87.8 13.3 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EEA05478.1 - 1.1e-18 67.0 10.3 1.6e-18 66.5 10.3 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EEA05478.1 - 3.1e-07 30.6 8.3 3.1e-07 30.6 8.3 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA05478.1 - 2.7e-05 23.9 4.5 2.7e-05 23.9 4.5 2.7 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA05478.1 - 0.00045 19.9 1.2 0.00045 19.9 1.2 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 EEA05478.1 - 0.0014 18.5 12.1 0.008 16.0 12.1 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EEA05478.1 - 0.17 12.0 9.4 2 8.6 10.1 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 EEA05478.1 - 0.2 11.7 7.7 0.67 10.0 7.7 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA05478.1 - 0.41 10.5 12.2 22 5.0 0.3 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA05478.1 - 0.71 9.5 14.1 0.11 12.2 4.1 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EEA05478.1 - 0.75 9.8 12.0 3.8 7.6 12.0 2.3 1 1 0 1 1 1 0 zinc-RING finger domain DUF2423 PF10338.9 EEA05479.1 - 3.5e-07 30.3 4.4 5e-07 29.8 4.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Adap_comp_sub PF00928.21 EEA05480.1 - 2.2e-57 194.5 7.1 3.6e-57 193.7 7.1 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EEA05480.1 - 5.3e-05 23.2 3.7 0.00014 21.8 3.7 1.7 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EEA05480.1 - 0.033 13.6 0.1 0.069 12.6 0.0 1.5 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain MarR PF01047.22 EEA05480.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 MarR family Lung_7-TM_R PF06814.13 EEA05481.1 - 0.042 13.1 22.9 0.13 11.4 22.9 1.8 1 1 0 1 1 1 0 Lung seven transmembrane receptor DUF2627 PF11118.8 EEA05481.1 - 3 8.5 4.5 0.9 10.2 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) VPS13 PF16908.5 EEA05482.1 - 2e-10 40.9 4.0 3.6e-10 40.1 0.8 3.1 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EEA05482.1 - 1.4e-05 25.2 2.5 1.5e-05 25.1 0.1 2.3 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 EF-hand_7 PF13499.6 EEA05483.1 - 1e-10 41.9 0.5 1.4e-05 25.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA05483.1 - 1.2e-08 34.2 0.1 0.0038 17.0 0.0 3.5 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EEA05483.1 - 3.1e-06 26.3 0.1 0.03 13.9 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 EEA05483.1 - 2.1e-05 24.8 0.0 0.0028 17.9 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EEA05483.1 - 0.00033 20.4 0.3 1.5 8.7 0.1 3.5 3 1 0 3 3 3 2 EF-hand domain pair DREV PF05219.12 EEA05483.1 - 0.051 12.7 0.1 0.14 11.2 0.0 1.8 1 1 0 1 1 1 0 DREV methyltransferase EF-hand_5 PF13202.6 EEA05483.1 - 0.063 12.8 2.2 12 5.5 0.0 3.4 4 0 0 4 4 4 0 EF hand VHP PF02209.19 EEA05483.1 - 0.18 11.9 0.4 5 7.3 0.0 2.6 2 0 0 2 2 2 0 Villin headpiece domain Rad21_Rec8_N PF04825.13 EEA05486.1 - 9.5e-11 41.8 0.2 3.2e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EEA05486.1 - 8.1e-07 28.2 0.0 1.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein HGTP_anticodon PF03129.20 EEA05487.1 - 1.7e-20 72.9 0.0 3.8e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EEA05487.1 - 7.9e-10 39.0 0.1 4.1e-09 36.7 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Ras PF00071.22 EEA05488.1 - 1.3e-56 190.7 0.2 1.5e-56 190.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA05488.1 - 2.4e-32 111.7 0.9 9e-32 109.8 0.1 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA05488.1 - 2.7e-14 53.0 0.1 3.5e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA05488.1 - 9.2e-06 25.3 0.2 0.0013 18.3 0.2 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA05488.1 - 0.00013 22.0 0.1 0.00021 21.3 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EEA05488.1 - 0.0023 17.8 0.0 0.35 10.6 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EEA05488.1 - 0.0034 17.1 0.3 0.05 13.3 0.3 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EEA05488.1 - 0.0093 15.9 0.2 1.5 8.7 0.0 2.4 1 1 2 3 3 3 1 RsgA GTPase Gtr1_RagA PF04670.12 EEA05488.1 - 0.011 15.1 0.0 0.017 14.4 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EEA05488.1 - 0.038 13.4 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DAP3 PF10236.9 EEA05488.1 - 0.062 12.5 0.0 0.16 11.1 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 EEA05488.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain IL8 PF00048.20 EEA05489.1 - 0.013 15.7 0.1 0.051 13.7 0.1 2.1 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like Gar1 PF04410.14 EEA05490.1 - 1.6e-17 63.7 0.4 1.6e-17 63.7 0.4 3.8 3 1 0 3 3 3 1 Gar1/Naf1 RNA binding region Actin PF00022.19 EEA05491.1 - 8.9e-32 110.2 0.0 1.3e-30 106.4 0.0 2.4 1 1 0 1 1 1 1 Actin Longin PF13774.6 EEA05491.1 - 0.15 12.1 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Regulated-SNARE-like domain Sec1 PF00995.23 EEA05492.1 - 5.1e-88 296.8 21.7 6.5e-88 296.4 21.7 1.0 1 0 0 1 1 1 1 Sec1 family CENP-Q PF13094.6 EEA05493.1 - 2.4 8.3 18.5 2.2 8.5 14.6 2.8 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit OSCP PF00213.18 EEA05494.1 - 1e-33 116.9 1.0 1.2e-33 116.6 1.0 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Arc_PepC_II PF06847.11 EEA05494.1 - 0.045 14.3 0.0 6.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II CRC_subunit PF08624.10 EEA05494.1 - 0.074 13.5 0.3 0.2 12.1 0.1 1.7 1 1 1 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Ribosomal_S7 PF00177.21 EEA05494.1 - 0.11 12.1 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e Nrap_D4 PF17405.2 EEA05495.1 - 2.5e-26 92.4 0.1 4.6e-26 91.5 0.1 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 EEA05495.1 - 6.1e-26 91.3 2.0 4.7e-23 81.9 2.0 2.8 1 1 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 EEA05495.1 - 2.6e-23 82.8 0.0 7e-23 81.5 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D5 PF17406.2 EEA05495.1 - 1e-18 67.6 0.0 1.9e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 EEA05495.1 - 0.002 18.3 0.1 0.0071 16.6 0.1 1.9 1 0 0 1 1 1 1 Nrap protein domain 6 ER_lumen_recept PF00810.18 EEA05496.1 - 1.3e-48 165.6 12.7 2e-48 165.0 12.7 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EEA05496.1 - 0.022 14.5 2.2 0.022 14.5 2.2 4.3 3 1 1 4 4 4 0 PQ loop repeat YycC PF14174.6 EEA05496.1 - 0.035 13.9 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 YycC-like protein 3HCDH PF00725.22 EEA05497.1 - 0.073 13.7 0.0 0.11 13.2 0.0 1.4 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GTP_EFTU PF00009.27 EEA05498.1 - 1.3e-33 116.2 0.1 2e-33 115.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Ras PF00071.22 EEA05498.1 - 9.1e-07 28.6 1.3 1e-05 25.2 0.1 2.4 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 EEA05498.1 - 1e-06 28.8 0.0 3.6e-05 23.8 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EEA05498.1 - 0.00054 20.2 0.1 0.056 13.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EEA05498.1 - 0.02 14.8 3.2 1.2 9.1 0.2 3.0 3 1 0 3 3 3 0 RsgA GTPase Dynamin_N PF00350.23 EEA05498.1 - 0.02 14.9 0.4 1.4 9.0 0.1 2.5 1 1 1 2 2 2 0 Dynamin family Arf PF00025.21 EEA05498.1 - 0.087 12.3 0.5 0.43 10.0 0.1 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF4934 PF16288.5 EEA05498.1 - 1.1 9.2 3.9 2.8 7.9 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4934) CRAL_TRIO PF00650.20 EEA05499.1 - 0.0041 16.8 0.2 0.0093 15.7 0.2 1.7 1 1 0 1 1 1 1 CRAL/TRIO domain Pcc1 PF09341.10 EEA05500.1 - 9.5e-10 38.5 0.0 1.1e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 CTP_transf_like PF01467.26 EEA05501.1 - 4.5e-33 114.4 0.2 1e-32 113.3 0.2 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like Mito_carr PF00153.27 EEA05502.1 - 3.4e-59 196.8 1.2 9.4e-21 73.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3836 PF12930.7 EEA05502.1 - 0.13 12.0 0.7 0.82 9.4 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF3836) Lin-8 PF03353.15 EEA05503.1 - 0.00082 19.0 0.4 0.0017 18.0 0.4 1.4 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist AF-4 PF05110.13 EEA05503.1 - 0.0033 15.6 19.4 0.0033 15.6 19.4 1.5 2 0 0 2 2 2 1 AF-4 proto-oncoprotein DUF3446 PF11928.8 EEA05503.1 - 0.017 15.4 22.5 0.048 14.0 22.5 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain Chorion_2 PF03964.15 EEA05503.1 - 0.048 14.5 5.9 0.1 13.4 5.9 1.5 1 0 0 1 1 1 0 Chorion family 2 DUF2740 PF10872.8 EEA05503.1 - 0.14 12.1 0.3 0.31 10.9 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Peptidase_M43 PF05572.13 EEA05503.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.9 3 1 1 4 4 4 0 Pregnancy-associated plasma protein-A CCDC24 PF15669.5 EEA05503.1 - 0.31 10.9 9.0 0.53 10.1 9.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DUF4698 PF15769.5 EEA05503.1 - 0.5 9.4 8.9 0.81 8.7 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) HEXIM PF15313.6 EEA05503.1 - 0.87 9.8 4.8 1.1 9.4 2.8 2.2 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein Pheromone PF08015.11 EEA05503.1 - 1.3 10.1 12.9 4.1 8.5 12.9 1.8 1 0 0 1 1 1 0 Fungal mating-type pheromone DUF4614 PF15391.6 EEA05503.1 - 1.6 8.7 15.7 3.7 7.5 15.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CCDC106 PF15794.5 EEA05503.1 - 1.7 8.3 9.1 3.7 7.2 9.1 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 NAM-associated PF14303.6 EEA05503.1 - 2 9.1 7.6 4.4 8.0 7.6 1.5 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain LRRFIP PF09738.9 EEA05503.1 - 2.8 7.3 6.7 7.1 6.0 6.7 1.6 1 0 0 1 1 1 0 LRRFIP family Herpes_capsid PF06112.11 EEA05503.1 - 4.1 7.4 17.0 8 6.5 17.0 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein PAP1 PF08601.10 EEA05503.1 - 9.4 5.8 27.3 0.33 10.6 20.4 1.8 2 0 0 2 2 2 0 Transcription factor PAP1 Aa_trans PF01490.18 EEA05504.1 - 1.1e-25 90.3 36.9 1.3e-25 90.0 36.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein WD40 PF00400.32 EEA05505.1 - 1.4e-12 47.9 4.9 1.9e-06 28.5 0.0 4.8 5 1 0 5 5 5 2 WD domain, G-beta repeat WD40_4 PF16300.5 EEA05505.1 - 4.4e-12 45.7 0.0 7.8e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Type of WD40 repeat ANAPC4_WD40 PF12894.7 EEA05505.1 - 2.5e-05 24.5 0.1 0.0005 20.3 0.1 3.1 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA05505.1 - 0.00016 20.7 0.2 0.00096 18.2 0.1 2.1 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1899 PF08953.11 EEA05505.1 - 0.00083 19.2 0.0 0.0025 17.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) Phage_GPO PF05929.11 EEA05505.1 - 0.2 11.3 4.0 0.41 10.2 4.0 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FapA PF03961.13 EEA05505.1 - 0.27 9.8 7.9 0.051 12.2 3.6 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A Ribosomal_S27e PF01667.17 EEA05506.1 - 0.0036 17.0 4.5 0.23 11.2 0.2 2.4 2 0 0 2 2 2 2 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EEA05506.1 - 0.042 13.4 1.2 0.042 13.4 1.2 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding RPA_interact_C PF14768.6 EEA05506.1 - 0.11 13.0 0.6 0.11 13.0 0.6 2.9 2 1 0 2 2 2 0 Replication protein A interacting C-terminal DUF2318 PF10080.9 EEA05506.1 - 0.15 12.2 8.0 1.4 9.0 0.5 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DZR PF12773.7 EEA05506.1 - 0.16 12.0 5.7 16 5.6 5.7 2.8 1 1 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 EEA05506.1 - 2.4 8.2 7.9 0.24 11.4 0.5 2.6 2 1 1 3 3 3 0 Putative transposase DNA-binding domain FYVE PF01363.21 EEA05506.1 - 4 7.6 8.7 0.89 9.7 0.7 2.8 1 1 1 2 2 2 0 FYVE zinc finger Auto_anti-p27 PF06677.12 EEA05506.1 - 7.4 6.8 7.0 5.8 7.2 0.6 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HECT PF00632.25 EEA05507.1 - 9.6e-93 311.0 2.3 3.2e-92 309.3 2.3 2.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Cir_N PF10197.9 EEA05507.1 - 1 9.6 3.5 2.7 8.2 3.5 1.7 1 0 0 1 1 1 0 N-terminal domain of CBF1 interacting co-repressor CIR Mito_carr PF00153.27 EEA05508.1 - 5.6e-66 218.5 6.4 1e-24 86.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.25 EEA05510.1 - 2.4e-47 161.5 0.0 1.2e-46 159.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05510.1 - 2.3e-19 69.7 0.0 1.3e-18 67.2 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA05510.1 - 8.3e-06 25.3 0.0 1.5e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FCP1_C PF09309.10 EEA05510.1 - 0.0055 16.6 0.1 0.0099 15.8 0.1 1.3 1 0 0 1 1 1 1 FCP1, C-terminal CENP-F_leu_zip PF10473.9 EEA05510.1 - 0.0069 16.4 3.3 0.018 15.1 3.3 1.6 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sbi-IV PF11621.8 EEA05510.1 - 0.043 14.2 1.2 0.12 12.8 0.1 2.3 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI APH PF01636.23 EEA05510.1 - 0.16 11.9 0.0 0.54 10.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family CAMSAP_CH PF11971.8 EEA05510.1 - 7.4 6.5 6.6 2.5 8.0 0.5 3.1 3 0 0 3 3 3 0 CAMSAP CH domain DNA_pol_B_exo1 PF03104.19 EEA05511.1 - 2e-59 201.5 6.1 6.9e-59 199.7 6.1 2.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF1744 PF08490.12 EEA05511.1 - 9.5e-37 126.5 10.3 2.8e-36 125.0 10.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.21 EEA05511.1 - 4.8e-12 45.3 3.6 1.5e-09 37.1 0.2 4.2 3 2 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EEA05511.1 - 3e-07 30.4 0.1 3.7e-05 23.5 0.0 2.7 2 0 0 2 2 2 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB zf-CHY PF05495.12 EEA05511.1 - 1.4 9.5 4.2 1.5 9.3 1.4 2.7 2 0 0 2 2 2 0 CHY zinc finger Sec23_trunk PF04811.15 EEA05512.1 - 1.4e-21 77.2 0.0 5.7e-21 75.2 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EEA05512.1 - 1.2e-15 58.0 1.3 4.3e-15 56.2 0.0 2.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EEA05512.1 - 4.6e-12 45.8 3.9 4.6e-12 45.8 3.9 2.3 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EEA05512.1 - 3.2e-10 39.7 0.9 2.9e-09 36.7 0.1 3.1 2 1 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EEA05512.1 - 0.00026 20.8 0.0 0.00064 19.6 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Ly49 PF08391.10 EEA05513.1 - 3 8.2 17.6 0.62 10.4 2.5 2.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region COG2 PF06148.11 EEA05513.1 - 7 6.7 12.5 6.7 6.8 2.1 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 SlyX PF04102.12 EEA05513.1 - 7.1 7.3 9.6 11 6.7 1.9 2.7 2 0 0 2 2 2 0 SlyX Clathrin PF00637.20 EEA05514.1 - 1.7e-141 465.6 65.6 9.8e-29 100.1 2.6 10.0 10 0 0 10 10 10 8 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EEA05514.1 - 1.8e-15 56.6 0.1 1.3e-13 50.6 0.0 3.6 3 0 0 3 3 3 1 Clathrin-H-link TPR_7 PF13176.6 EEA05514.1 - 0.022 14.8 3.4 25 5.2 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA05514.1 - 0.072 13.0 7.1 14 5.7 0.3 5.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Phage_int_SAM_3 PF14659.6 EEA05514.1 - 0.11 12.8 3.0 2 8.7 0.0 3.6 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain TPR_8 PF13181.6 EEA05514.1 - 0.14 12.5 6.6 38 4.8 0.1 6.4 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA05514.1 - 0.46 10.7 2.9 60 4.1 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat RICTOR_M PF14666.6 EEA05514.1 - 0.52 10.1 4.0 0.45 10.3 0.3 2.9 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain ANAPC3 PF12895.7 EEA05514.1 - 9.4 6.5 7.5 4 7.7 0.3 4.1 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_1 PF00036.32 EEA05515.1 - 1e-29 99.8 8.3 1.4e-08 33.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA05515.1 - 3e-27 94.8 4.6 9.5e-15 54.8 1.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA05515.1 - 2.9e-24 82.9 5.8 2e-08 33.5 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EEA05515.1 - 5.6e-17 61.3 8.2 2.9e-09 36.6 0.5 3.7 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EEA05515.1 - 3.2e-15 54.8 13.2 2.3e-06 26.8 0.0 4.7 4 1 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EEA05515.1 - 2.1e-11 44.0 0.2 6.2e-06 26.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA05515.1 - 1.4e-05 25.0 3.8 0.07 13.1 0.2 3.1 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EEA05515.1 - 2.3e-05 24.7 0.5 0.026 14.9 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain TerB PF05099.13 EEA05515.1 - 0.00015 21.8 0.1 0.022 14.7 0.0 2.8 2 1 1 3 3 3 1 Tellurite resistance protein TerB SUB1_ProdP9 PF18213.1 EEA05515.1 - 0.0012 18.6 0.2 0.0031 17.3 0.2 1.7 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 SPARC_Ca_bdg PF10591.9 EEA05515.1 - 0.0014 19.0 0.1 1.8 8.9 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 EEA05515.1 - 0.0016 18.4 0.2 0.79 9.6 0.0 2.9 2 1 1 3 3 3 1 Caleosin related protein DUF1257 PF06868.11 EEA05515.1 - 0.022 15.0 0.0 0.034 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) EF-hand_11 PF08976.11 EEA05515.1 - 0.023 15.6 0.1 0.4 11.6 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 EEA05515.1 - 0.029 14.6 1.4 1.5 9.1 0.1 2.6 1 1 2 3 3 3 0 Dockerin type I domain Toprim_2 PF13155.6 EEA05515.1 - 0.079 13.4 0.5 0.44 11.0 0.5 2.2 1 1 0 1 1 1 0 Toprim-like Skp1 PF01466.19 EEA05515.1 - 0.079 13.1 0.8 7.6 6.7 0.0 2.8 3 0 0 3 3 3 0 Skp1 family, dimerisation domain DUF3008 PF11450.8 EEA05515.1 - 0.12 12.6 1.0 0.3 11.3 0.2 2.1 3 0 0 3 3 2 0 Protein of unknwon function (DUF3008) Nexin_C PF08628.12 EEA05515.1 - 0.12 13.0 0.0 0.29 11.7 0.0 1.8 2 1 0 2 2 2 0 Sorting nexin C terminal DUF2207 PF09972.9 EEA05516.1 - 0.0007 18.5 1.7 0.0007 18.5 1.7 3.6 2 1 1 3 3 3 1 Predicted membrane protein (DUF2207) DUF2870 PF11069.8 EEA05516.1 - 0.17 12.3 0.7 0.27 11.6 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) SLC3A2_N PF16028.5 EEA05516.1 - 0.41 10.2 5.5 3.3 7.3 3.7 2.9 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus SMC_N PF02463.19 EEA05517.1 - 6.4e-18 65.0 0.0 1.4e-17 63.9 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EEA05517.1 - 2.6e-11 44.4 8.0 2.6e-11 44.4 8.0 7.4 2 1 3 5 5 5 1 AAA domain AAA_29 PF13555.6 EEA05517.1 - 0.0024 17.6 0.0 0.0052 16.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATP-synt_ab_N PF02874.23 EEA05517.1 - 0.18 12.4 0.2 0.67 10.5 0.2 2.0 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain AAA_lid_10 PF17872.1 EEA05518.1 - 0.23 11.6 4.3 0.3 11.2 0.4 2.5 2 0 0 2 2 2 0 AAA lid domain Peptidase_C2 PF00648.21 EEA05519.1 - 6.1e-37 127.2 2.0 2e-36 125.5 1.4 2.1 2 1 0 2 2 2 1 Calpain family cysteine protease DUF4834 PF16118.5 EEA05520.1 - 0.19 12.7 4.6 0.079 13.9 2.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Med14 PF08638.11 EEA05521.1 - 6.1e-09 35.6 0.1 1.8e-08 34.1 0.1 1.8 1 0 0 1 1 1 1 Mediator complex subunit MED14 TP6A_N PF04406.14 EEA05522.1 - 1e-14 54.2 0.1 1.9e-14 53.3 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase PORR PF11955.8 EEA05523.1 - 0.0052 15.8 0.2 0.21 10.5 0.1 2.2 2 0 0 2 2 2 2 Plant organelle RNA recognition domain TPT PF03151.16 EEA05524.1 - 2.7e-24 86.0 31.8 3.6e-24 85.6 31.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA05524.1 - 1.4e-09 38.3 43.1 1.3e-08 35.1 16.3 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EEA05524.1 - 1.1e-06 28.1 36.5 1.1e-06 28.1 36.5 1.6 1 1 1 2 2 2 1 UAA transporter family CBM_20 PF00686.19 EEA05525.1 - 0.023 14.6 0.5 0.14 12.1 0.0 2.6 2 1 0 2 2 2 0 Starch binding domain Acyltransferase PF01553.21 EEA05527.1 - 7.4e-14 51.5 0.3 1.8e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 Acyltransferase GerA PF03323.13 EEA05527.1 - 0.7 8.3 4.0 0.92 7.9 4.0 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein DNA_primase_lrg PF04104.14 EEA05528.1 - 2.4e-79 266.5 2.1 9.3e-79 264.6 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit ATPgrasp_ST PF14397.6 EEA05528.1 - 0.01 15.1 1.8 0.017 14.3 1.8 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp SpoIIE PF07228.12 EEA05529.1 - 1.8e-05 24.8 0.0 1.1 9.1 0.0 3.1 3 0 0 3 3 3 3 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EEA05529.1 - 0.0034 17.1 0.0 0.029 14.0 0.0 2.3 1 1 0 1 1 1 1 Protein phosphatase 2C Evr1_Alr PF04777.13 EEA05530.1 - 2.8e-05 24.5 0.2 4.5e-05 23.8 0.2 1.4 1 0 0 1 1 1 1 Erv1 / Alr family TPT PF03151.16 EEA05531.1 - 1.4e-18 67.3 30.0 1.6e-18 67.1 30.0 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA05531.1 - 1.4e-06 28.6 41.8 0.00037 20.7 16.2 2.5 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 EEA05531.1 - 0.015 14.6 26.4 0.11 11.6 24.5 2.8 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport WD40 PF00400.32 EEA05532.1 - 5.3e-39 131.5 21.5 6.1e-05 23.7 0.0 10.1 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA05532.1 - 1.3e-12 47.8 2.9 0.00081 19.6 0.0 7.3 4 2 5 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA05532.1 - 8.6e-06 24.7 1.9 1.5 7.3 0.0 5.6 4 2 1 6 6 6 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EEA05532.1 - 0.0012 18.2 13.4 0.0042 16.5 0.1 4.9 4 1 1 5 5 5 2 WD40-like domain Sin_N PF04801.13 EEA05533.1 - 6.2e-43 147.6 0.0 6.2e-24 85.0 0.0 2.4 2 0 0 2 2 2 2 Sin-like protein conserved region RNA_GG_bind PF10258.9 EEA05534.1 - 2.9e-23 81.7 0.0 5e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain SPAR_C PF11881.8 EEA05534.1 - 0.031 14.2 1.7 0.046 13.6 1.7 1.1 1 0 0 1 1 1 0 C-terminal domain of SPAR protein VWD PF00094.25 EEA05534.1 - 0.046 14.0 0.0 0.06 13.6 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type D domain Surp PF01805.20 EEA05535.1 - 3.3e-15 55.8 0.7 9.3e-15 54.4 0.7 1.9 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 EEA05535.1 - 2.9e-12 46.2 0.0 8.8e-12 44.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA05535.1 - 0.0064 16.1 0.0 0.024 14.2 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EEA05535.1 - 0.016 15.2 0.0 3.6 7.7 0.0 2.7 2 0 0 2 2 2 0 RNA binding domain CTD_bind PF04818.13 EEA05535.1 - 0.047 14.5 0.5 0.12 13.2 0.5 1.8 1 0 0 1 1 1 0 RNA polymerase II-binding domain. Y_phosphatase3 PF13350.6 EEA05536.1 - 1.4e-27 97.2 0.0 2.5e-25 89.8 0.0 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EEA05536.1 - 0.002 17.8 1.7 0.034 13.7 0.0 3.2 2 1 2 4 4 4 1 Tyrosine phosphatase family FH2 PF02181.23 EEA05537.1 - 1.2e-43 149.7 12.8 1.2e-43 149.7 12.8 2.9 2 1 1 3 3 3 1 Formin Homology 2 Domain DUF3399 PF11879.8 EEA05537.1 - 0.026 14.9 1.3 3.3 8.1 0.0 3.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3399) PAP1 PF08601.10 EEA05537.1 - 0.037 13.7 15.9 0.088 12.5 15.9 1.6 1 0 0 1 1 1 0 Transcription factor PAP1 Spc7 PF08317.11 EEA05539.1 - 0.00016 20.7 47.4 0.00049 19.1 27.0 6.6 3 1 4 8 8 8 4 Spc7 kinetochore protein DUF1664 PF07889.12 EEA05539.1 - 0.0046 17.0 3.9 0.0046 17.0 3.9 8.8 3 2 7 10 10 10 4 Protein of unknown function (DUF1664) DUF1515 PF07439.11 EEA05539.1 - 0.74 9.9 15.6 0.59 10.2 0.8 4.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) UCH PF00443.29 EEA05540.1 - 1.8e-51 175.1 0.5 5.7e-51 173.5 0.5 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA05540.1 - 7.7e-19 68.4 0.9 7.5e-18 65.2 0.9 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Inhibitor_I36 PF03995.13 EEA05540.1 - 0.76 9.7 2.8 6.6 6.7 0.2 3.1 2 0 0 2 2 2 0 Peptidase inhibitor family I36 CotJB PF12652.7 EEA05541.1 - 0.06 13.6 4.2 0.69 10.2 0.5 2.7 2 0 0 2 2 2 0 CotJB protein zf-C2H2_2 PF12756.7 EEA05542.1 - 1.9e-23 82.7 1.2 1.9e-23 82.7 1.2 3.1 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EEA05542.1 - 0.00022 21.4 2.2 0.0043 17.3 0.1 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EEA05542.1 - 0.00033 21.2 3.4 0.022 15.5 0.4 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EEA05542.1 - 0.00033 20.9 6.1 0.027 14.9 0.8 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EEA05542.1 - 0.011 16.1 3.5 1.4 9.4 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EEA05542.1 - 0.26 11.4 2.2 1.5 8.9 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Pro_isomerase PF00160.21 EEA05543.1 - 2.1e-42 145.1 0.0 2.6e-42 144.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-CCCH_4 PF18044.1 EEA05544.1 - 3.1e-06 26.8 5.8 5.5e-06 26.1 5.8 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EEA05544.1 - 3.8e-05 23.6 5.0 7e-05 22.7 5.0 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EEA05544.1 - 9.3e-05 22.2 5.1 0.00014 21.6 5.1 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EEA05544.1 - 0.3 11.6 4.4 0.6 10.7 4.4 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EEA05544.1 - 0.37 11.5 0.2 0.37 11.5 0.2 2.1 2 0 0 2 2 2 0 Torus domain Ribo_biogen_C PF04034.13 EEA05545.1 - 6.9e-41 138.9 0.0 1.5e-40 137.8 0.0 1.6 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EEA05545.1 - 1.7e-07 31.0 2.5 2.7e-07 30.3 2.5 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI CDC45 PF02724.14 EEA05545.1 - 0.2 9.9 3.5 0.24 9.6 3.5 1.1 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 EEA05547.1 - 1.9e-42 145.5 37.4 2.1e-38 132.1 25.3 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2101 PF09874.9 EEA05547.1 - 2.1 8.0 7.4 4.6 6.9 7.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) DUF3883 PF13020.6 EEA05548.1 - 7.4e-09 35.5 0.0 3.1e-08 33.5 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) HATPase_c_3 PF13589.6 EEA05548.1 - 0.00034 20.5 0.0 0.00084 19.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_pol_D_N PF18018.1 EEA05549.1 - 3.5e-34 117.7 0.2 5.9e-34 117.0 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 EEA05549.1 - 2.9e-28 98.7 0.6 4.9e-28 97.9 0.6 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF749 PF05370.11 EEA05549.1 - 0.089 12.9 0.6 0.29 11.2 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF749) F-box PF00646.33 EEA05550.1 - 2.9e-05 23.8 0.0 0.00015 21.6 0.0 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EEA05550.1 - 0.007 16.2 0.0 0.024 14.5 0.0 2.0 1 0 0 1 1 1 1 F-box-like SLD5_C PF16922.5 EEA05551.1 - 0.0067 16.6 0.1 0.024 14.8 0.0 2.0 2 1 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EEA05551.1 - 0.1 13.1 1.0 0.17 12.4 0.4 1.7 2 0 0 2 2 2 0 GINS complex protein PRA1 PF03208.19 EEA05552.1 - 5.4e-23 81.2 2.6 7e-23 80.8 2.6 1.1 1 0 0 1 1 1 1 PRA1 family protein YwiC PF14256.6 EEA05552.1 - 0.017 15.5 0.7 0.041 14.2 0.1 1.8 2 0 0 2 2 2 0 YwiC-like protein FliD_C PF07195.12 EEA05552.1 - 0.017 14.5 3.2 0.024 14.0 3.2 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus FA_desaturase PF00487.24 EEA05552.1 - 0.08 12.8 4.2 3 7.6 0.5 2.1 1 1 1 2 2 2 0 Fatty acid desaturase DUF423 PF04241.15 EEA05552.1 - 1.9 8.7 7.2 3.7 7.8 5.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF423) KH_1 PF00013.29 EEA05553.1 - 0.00037 20.3 0.1 0.00086 19.1 0.1 1.6 1 0 0 1 1 1 1 KH domain Pkinase PF00069.25 EEA05554.1 - 7.5e-33 114.0 0.0 5.2e-30 104.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05554.1 - 8.9e-14 51.4 0.0 1.6e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA05554.1 - 3.1e-09 36.6 0.0 5e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA05554.1 - 0.0093 14.8 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EEA05554.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA05554.1 - 0.028 13.4 2.1 0.098 11.6 0.0 2.3 2 1 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 EEA05554.1 - 0.044 13.7 0.1 0.082 12.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ATP-synt_ab PF00006.25 EEA05555.1 - 4.8e-66 222.5 0.0 6.3e-66 222.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EEA05555.1 - 4.9e-12 46.2 1.1 8.9e-12 45.4 1.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EEA05555.1 - 0.22 11.7 1.0 0.46 10.7 1.0 1.5 1 0 0 1 1 1 0 HAS barrel domain W2 PF02020.18 EEA05556.1 - 0.00016 21.7 0.9 0.00053 20.1 0.9 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon CENP-K PF11802.8 EEA05557.1 - 0.0068 16.0 10.9 0.0081 15.8 10.9 1.0 1 0 0 1 1 1 1 Centromere-associated protein K AAA_13 PF13166.6 EEA05557.1 - 0.022 13.4 6.5 0.026 13.2 6.5 1.0 1 0 0 1 1 1 0 AAA domain GAS PF13851.6 EEA05557.1 - 0.034 13.5 17.3 0.18 11.1 17.3 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EEA05557.1 - 0.041 12.8 11.9 0.044 12.7 11.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3053 PF11254.8 EEA05557.1 - 0.046 13.3 2.0 0.052 13.1 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) DUF1515 PF07439.11 EEA05557.1 - 0.052 13.6 5.8 0.11 12.5 5.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) ST7 PF04184.12 EEA05557.1 - 0.061 11.8 2.4 0.07 11.6 2.4 1.0 1 0 0 1 1 1 0 ST7 protein YbfN PF13982.6 EEA05557.1 - 0.065 13.5 1.0 0.21 11.9 0.1 2.0 1 1 1 2 2 2 0 YbfN-like lipoprotein Com_YlbF PF06133.11 EEA05557.1 - 0.066 13.8 10.0 0.096 13.3 10.0 1.3 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA Sulfotransfer_2 PF03567.14 EEA05557.1 - 0.076 12.9 2.6 0.095 12.6 2.6 1.1 1 0 0 1 1 1 0 Sulfotransferase family DUF724 PF05266.14 EEA05557.1 - 0.086 12.7 9.6 0.097 12.5 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 EEA05557.1 - 0.09 12.0 8.5 0.1 11.9 8.5 1.0 1 0 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 EEA05557.1 - 0.15 12.2 9.2 0.18 11.9 9.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Allexi_40kDa PF05549.11 EEA05557.1 - 0.16 11.5 4.5 0.22 11.0 4.5 1.2 1 1 0 1 1 1 0 Allexivirus 40kDa protein HIP1_clath_bdg PF16515.5 EEA05557.1 - 0.18 12.4 10.0 0.18 12.4 8.9 1.5 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 EF-G-binding_N PF07299.11 EEA05557.1 - 0.2 12.2 8.7 1.1 9.8 1.0 2.1 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal Aminopep PF10023.9 EEA05557.1 - 0.21 10.9 3.7 0.23 10.8 3.7 1.0 1 0 0 1 1 1 0 Putative aminopeptidase DUF725 PF05267.12 EEA05557.1 - 0.21 11.6 3.5 0.39 10.7 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF725) CorA PF01544.18 EEA05557.1 - 0.22 10.8 6.2 0.28 10.5 6.2 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Occludin_ELL PF07303.13 EEA05557.1 - 0.25 12.1 8.7 0.16 12.7 2.4 2.1 1 1 0 2 2 2 0 Occludin homology domain Syntaxin-6_N PF09177.11 EEA05557.1 - 0.26 11.9 8.5 1.6 9.4 2.9 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF3958 PF13125.6 EEA05557.1 - 0.27 11.4 12.4 0.46 10.7 12.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3958) DUF3810 PF12725.7 EEA05557.1 - 0.29 10.4 2.2 0.37 10.1 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) TPR_MLP1_2 PF07926.12 EEA05557.1 - 0.32 11.1 13.7 0.52 10.4 12.4 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FapA PF03961.13 EEA05557.1 - 0.33 9.5 8.9 0.36 9.4 8.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A STAG PF08514.11 EEA05557.1 - 0.45 10.4 5.6 0.2 11.6 2.8 1.8 1 1 1 2 2 2 0 STAG domain Rho_Binding PF08912.11 EEA05557.1 - 0.6 11.0 13.6 0.23 12.3 6.2 2.2 1 1 1 2 2 2 0 Rho Binding OmpH PF03938.14 EEA05557.1 - 0.66 10.3 11.7 1.1 9.5 11.8 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1664 PF07889.12 EEA05557.1 - 0.7 9.9 6.8 1 9.4 5.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2721 PF11026.8 EEA05557.1 - 0.79 9.6 1.9 1.2 9.0 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Arc_PepC_II PF06847.11 EEA05557.1 - 0.8 10.3 3.4 5.1 7.7 2.8 2.0 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Atg14 PF10186.9 EEA05557.1 - 1.1 8.2 9.6 1.3 8.0 9.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 EEA05557.1 - 1.5 9.5 10.3 2.2 9.0 9.6 1.6 1 1 1 2 2 2 0 Initiation control protein YabA DUF948 PF06103.11 EEA05557.1 - 2.5 8.4 4.4 23 5.3 1.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4404 PF14357.6 EEA05557.1 - 2.5 8.8 8.0 4.9 7.9 0.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) UPF0449 PF15136.6 EEA05557.1 - 2.7 8.5 9.1 2.4 8.6 1.4 2.6 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 CCDC-167 PF15188.6 EEA05557.1 - 6.1 7.3 14.6 6.2 7.2 9.7 2.0 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 LMBR1 PF04791.16 EEA05557.1 - 7.1 5.4 6.5 8.6 5.1 6.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fe-ADH PF00465.19 EEA05558.1 - 4.1e-52 177.2 0.0 1.3e-51 175.6 0.0 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EEA05558.1 - 0.00039 20.2 1.5 0.00083 19.1 0.1 2.0 1 1 1 2 2 2 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 EEA05559.1 - 5.9e-111 370.8 0.0 1e-110 370.0 0.0 1.4 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Aldedh PF00171.22 EEA05559.1 - 3.1e-21 75.5 1.6 2.3e-20 72.6 1.6 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Fe-ADH_2 PF13685.6 EEA05559.1 - 1.7e-18 67.3 1.3 1.5e-08 34.6 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DUF1902 PF08972.11 EEA05559.1 - 0.032 14.2 0.3 0.11 12.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) ThiF PF00899.21 EEA05560.1 - 2.5e-46 158.0 0.0 3.2e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family LEA_6 PF10714.9 EEA05560.1 - 0.082 13.0 0.2 0.16 12.1 0.2 1.4 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 VirD1 PF07328.11 EEA05561.1 - 0.047 13.7 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 T-DNA border endonuclease VirD1 SHMT PF00464.19 EEA05563.1 - 0.014 14.0 0.1 0.039 12.5 0.0 1.6 2 0 0 2 2 2 0 Serine hydroxymethyltransferase CmlA_N PF18456.1 EEA05563.1 - 0.034 13.5 0.3 0.058 12.7 0.3 1.4 1 1 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain SHMT PF00464.19 EEA05564.1 - 3.5e-09 35.7 0.0 4.3e-09 35.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase ubiquitin PF00240.23 EEA05565.1 - 2e-09 37.1 0.1 0.067 12.9 0.0 6.4 8 0 0 8 8 8 2 Ubiquitin family Rad60-SLD PF11976.8 EEA05565.1 - 5.5e-06 26.1 0.7 1.2 9.1 0.0 5.8 6 0 0 6 6 6 2 Ubiquitin-2 like Rad60 SUMO-like RBD PF02196.15 EEA05565.1 - 0.0017 18.4 0.0 0.12 12.4 0.0 3.6 4 0 0 4 4 4 1 Raf-like Ras-binding domain UBX PF00789.20 EEA05565.1 - 0.013 15.7 0.1 0.33 11.2 0.0 3.2 2 0 0 2 2 2 0 UBX domain Metal_resist PF13801.6 EEA05566.1 - 0.00045 20.4 13.2 15 5.8 0.2 6.0 1 1 7 8 8 8 5 Heavy-metal resistance fn2 PF00040.19 EEA05566.1 - 0.002 18.4 1.1 87 3.5 0.0 6.4 8 0 0 8 8 8 0 Fibronectin type II domain Glutenin_hmw PF03157.13 EEA05566.1 - 0.0064 15.0 1.3 0.01 14.3 1.3 1.3 1 0 0 1 1 1 1 High molecular weight glutenin subunit APG6_N PF17675.1 EEA05569.1 - 1.1 9.7 19.2 0.66 10.5 6.4 2.6 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF575 PF04746.12 EEA05569.1 - 2.8 8.2 4.8 3.3 8.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF575) SURF6 PF04935.12 EEA05570.1 - 4.1e-11 43.0 34.8 4.1e-11 43.0 34.8 1.9 2 0 0 2 2 2 1 Surfeit locus protein 6 Alpha_L_fucos PF01120.17 EEA05570.1 - 1.9 7.8 9.1 4.3 6.7 9.1 1.7 1 1 0 1 1 1 0 Alpha-L-fucosidase DEAD PF00270.29 EEA05571.1 - 9.9e-45 152.4 0.0 1.4e-44 152.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA05571.1 - 2.8e-28 98.5 0.6 3.1e-27 95.1 0.3 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain LisH PF08513.11 EEA05572.1 - 0.00069 19.5 1.6 0.0012 18.7 0.8 1.9 2 0 0 2 2 2 1 LisH CLTH PF10607.9 EEA05572.1 - 0.0052 16.7 6.7 0.02 14.8 3.7 2.1 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain TPR_2 PF07719.17 EEA05572.1 - 0.016 15.3 1.6 1.6 9.0 0.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA05572.1 - 0.048 13.5 3.2 2.9 7.8 0.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat PFU PF09070.11 EEA05572.1 - 0.064 13.5 2.6 0.67 10.2 0.3 2.2 2 0 0 2 2 2 0 PFU (PLAA family ubiquitin binding) Cmc1 PF08583.10 EEA05572.1 - 0.12 12.4 0.3 2.3 8.3 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like eRF1_1 PF03463.15 EEA05573.1 - 3.9e-31 107.7 0.0 6.7e-31 107.0 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EEA05573.1 - 1.3e-21 77.1 0.0 3.4e-20 72.6 0.0 2.5 1 1 1 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.15 EEA05573.1 - 3.6e-10 40.3 0.0 9.1e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 2 DUF3216 PF11505.8 EEA05573.1 - 0.055 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) S4 PF01479.25 EEA05574.1 - 9e-11 41.3 0.6 2.2e-10 40.1 0.6 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EEA05574.1 - 3.2e-07 31.2 0.4 6e-07 30.3 0.4 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain E2F_TDP PF02319.20 EEA05575.1 - 5.2e-13 48.8 0.0 9.9e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain ANAPC4_WD40 PF12894.7 EEA05576.1 - 2.2e-09 37.5 0.0 0.00065 20.0 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EEA05576.1 - 1.2e-05 25.1 0.1 2.6e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 LisH WD40 PF00400.32 EEA05576.1 - 0.094 13.6 0.2 4.8 8.2 0.1 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 EEA05577.1 - 3.8e-08 33.1 11.6 3.8e-08 33.1 11.6 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA05577.1 - 1.5e-06 27.9 12.9 4.4e-06 26.5 12.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA05577.1 - 4.1e-06 26.5 12.2 7.5e-06 25.7 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA05577.1 - 2e-05 24.4 12.3 4.4e-05 23.3 12.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EEA05577.1 - 7e-05 23.1 13.2 7e-05 23.1 13.2 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.6 EEA05577.1 - 0.00071 19.4 7.4 0.0018 18.1 7.4 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 EEA05577.1 - 0.0058 16.6 9.3 0.0058 16.6 9.3 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-Nse PF11789.8 EEA05577.1 - 0.15 11.9 6.3 0.38 10.6 6.3 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_5 PF17121.5 EEA05577.1 - 0.16 11.9 9.9 0.17 11.8 7.1 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Siva PF05458.12 EEA05577.1 - 0.25 11.0 4.9 0.49 10.1 4.9 1.5 1 0 0 1 1 1 0 Cd27 binding protein (Siva) VPS9 PF02204.18 EEA05578.1 - 1.3e-20 73.5 0.1 3.8e-20 72.0 0.1 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EEA05578.1 - 0.0007 19.9 2.9 0.0009 19.5 0.5 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF5601) LRAT PF04970.13 EEA05578.1 - 0.75 10.1 4.8 6.1 7.2 1.0 3.2 3 1 0 3 3 3 0 Lecithin retinol acyltransferase ELMO_CED12 PF04727.13 EEA05579.1 - 4.5e-37 127.9 1.7 9.6e-37 126.8 1.7 1.6 1 0 0 1 1 1 1 ELMO/CED-12 family Plant_all_beta PF10532.9 EEA05579.1 - 0.033 14.5 9.3 0.068 13.5 8.6 1.9 1 1 0 1 1 1 0 Plant specific N-all beta domain PMAIP1 PF15150.6 EEA05579.1 - 0.19 11.6 0.3 0.42 10.5 0.3 1.5 1 0 0 1 1 1 0 Phorbol-12-myristate-13-acetate-induced DUF5474 PF17568.2 EEA05580.1 - 0.0024 17.9 1.2 0.0024 17.9 1.2 2.2 2 1 0 2 2 2 1 Family of unknown function (DUF5474) Snapin_Pallidin PF14712.6 EEA05581.1 - 0.081 13.4 6.2 16 6.0 0.9 3.5 3 0 0 3 3 3 0 Snapin/Pallidin ENTH PF01417.20 EEA05582.1 - 5.8e-35 120.1 0.1 1.5e-34 118.8 0.1 1.7 1 0 0 1 1 1 1 ENTH domain RNase_HII PF01351.18 EEA05582.1 - 0.09 12.6 3.7 7.6 6.3 1.1 2.4 2 0 0 2 2 2 0 Ribonuclease HII PMI_typeI PF01238.21 EEA05583.1 - 2e-71 241.1 0.3 7.3e-71 239.3 0.3 1.8 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cnd1 PF12717.7 EEA05583.1 - 0.086 12.9 1.9 0.26 11.3 1.9 1.8 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EEA05584.1 - 9.3e-21 72.1 15.0 0.0046 17.1 0.1 11.0 10 0 0 10 10 10 5 HEAT repeat CLASP_N PF12348.8 EEA05584.1 - 5.6e-15 55.5 10.2 2.7e-10 40.2 0.2 6.6 6 1 1 7 7 7 2 CLASP N terminal HEAT_EZ PF13513.6 EEA05584.1 - 2.3e-11 43.9 2.8 0.045 14.3 0.0 7.7 7 0 0 7 7 7 3 HEAT-like repeat HEAT_2 PF13646.6 EEA05584.1 - 4.9e-09 36.5 0.1 5.2 7.5 0.0 6.8 6 0 0 6 6 6 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EEA05584.1 - 4.8e-08 33.5 14.2 0.17 12.5 0.0 9.1 9 0 0 9 9 9 4 Vacuolar 14 Fab1-binding region DUF3437 PF11919.8 EEA05584.1 - 0.16 11.9 0.0 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) ERCC3_RAD25_C PF16203.5 EEA05585.1 - 1.7e-107 358.3 0.1 2.8e-107 357.6 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EEA05585.1 - 2.3e-27 95.6 0.0 3.9e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA05585.1 - 2.9e-14 53.4 0.0 8.3e-14 51.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA05585.1 - 3.6e-09 37.0 0.4 2.6e-08 34.2 0.1 2.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EEA05585.1 - 3.9e-06 25.8 0.0 6.8e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Pept_S41_N PF18294.1 EEA05585.1 - 0.019 15.0 0.3 0.054 13.5 0.3 1.8 1 0 0 1 1 1 0 Peptidase S41 N-terminal domain AChE_tetra PF08674.10 EEA05585.1 - 0.087 12.5 0.1 0.24 11.1 0.1 1.8 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain Cwf_Cwc_15 PF04889.12 EEA05586.1 - 4.2e-28 98.7 28.5 1.5e-26 93.6 25.0 2.2 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein NAD_kinase PF01513.21 EEA05588.1 - 6e-54 183.2 0.0 9.1e-54 182.6 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EEA05588.1 - 0.057 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain ANAPC4_WD40 PF12894.7 EEA05589.1 - 2.2e-09 37.5 0.0 0.011 16.0 0.0 3.4 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA05589.1 - 2.6e-09 37.6 3.7 0.17 12.8 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Dynamin_N PF00350.23 EEA05590.1 - 2.4e-16 60.2 0.1 8.5e-16 58.5 0.1 2.0 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EEA05590.1 - 0.00019 21.5 0.4 0.0029 17.7 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA05590.1 - 0.015 14.8 0.1 4.8 6.7 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B GTP_EFTU PF00009.27 EEA05590.1 - 0.086 12.4 0.0 0.92 9.0 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain GNAT_acetyltr_2 PF13718.6 EEA05591.1 - 7.3e-78 261.1 0.0 1.3e-77 260.2 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EEA05591.1 - 6.5e-56 189.0 0.0 1.3e-55 188.0 0.0 1.5 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 EEA05591.1 - 2e-45 155.3 0.3 3.7e-45 154.5 0.3 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 EEA05591.1 - 1.6e-25 88.8 0.0 5.2e-25 87.2 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_1 PF00583.25 EEA05592.1 - 3.7e-09 36.8 0.8 1.7e-08 34.7 0.8 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA05592.1 - 8e-07 29.4 0.5 1.4e-06 28.6 0.3 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EEA05592.1 - 1.9e-05 24.3 10.5 3.1e-05 23.5 10.5 1.4 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_10 PF13673.7 EEA05592.1 - 4.4e-05 23.4 0.0 0.00018 21.4 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA05592.1 - 0.00019 21.3 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA05592.1 - 0.012 15.7 0.1 5.5 7.1 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA05592.1 - 0.015 15.4 1.9 0.029 14.5 0.5 2.2 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain OGG_N PF07934.12 EEA05593.1 - 4e-23 81.8 6.3 7.6e-22 77.7 6.3 2.6 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EEA05593.1 - 1.8e-08 34.8 0.0 3.7e-07 30.6 0.0 2.3 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EEA05593.1 - 0.0032 17.2 0.0 0.0083 16.0 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif TBP PF00352.21 EEA05594.1 - 7.1e-55 182.9 0.0 9.4e-27 92.8 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EEA05594.1 - 0.0036 17.4 0.0 0.28 11.3 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) BTB_2 PF02214.22 EEA05595.1 - 6.7e-14 52.0 0.1 2.1e-13 50.4 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 EEA05595.1 - 0.073 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain S1 PF00575.23 EEA05596.1 - 3.4e-24 85.0 9.1 0.00015 22.0 0.0 8.2 9 0 0 9 9 9 5 S1 RNA binding domain Suf PF05843.14 EEA05596.1 - 2.5e-06 27.7 16.0 0.049 13.6 2.0 4.0 1 1 2 3 3 3 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EEA05596.1 - 1.7e-05 25.2 0.0 0.12 12.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA05596.1 - 5.7e-05 23.6 0.0 0.17 12.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EEA05596.1 - 0.001 18.3 7.2 0.012 14.8 0.2 2.7 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference TPR_16 PF13432.6 EEA05596.1 - 0.045 14.4 0.0 59 4.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat EXOSC1 PF10447.9 EEA05596.1 - 3.5 8.3 11.7 3.7 8.2 0.5 5.1 6 0 0 6 6 6 0 Exosome component EXOSC1/CSL4 E1-E2_ATPase PF00122.20 EEA05600.1 - 3e-26 92.0 0.2 3e-26 92.0 0.2 2.3 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EEA05600.1 - 7.8e-11 42.7 0.0 1e-05 26.0 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 EEA05600.1 - 8.6e-09 35.6 0.1 2.6e-08 34.0 0.1 1.8 1 0 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase PF13246.6 EEA05600.1 - 1.8e-06 27.9 0.1 4.2e-06 26.7 0.1 1.7 1 1 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA05600.1 - 0.012 15.4 0.3 0.36 10.5 0.0 2.9 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Ran_BP1 PF00638.18 EEA05601.1 - 4.3e-08 33.5 4.1 9.3e-08 32.4 0.9 2.7 2 1 0 2 2 2 1 RanBP1 domain NUP50 PF08911.11 EEA05601.1 - 0.00019 22.0 0.6 0.00049 20.7 0.6 1.8 1 0 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) PX PF00787.24 EEA05602.1 - 2.2e-09 37.3 0.6 3.1e-09 36.8 0.6 1.2 1 0 0 1 1 1 1 PX domain MIR PF02815.19 EEA05603.1 - 6.7e-05 22.8 0.0 0.03 14.2 0.0 2.2 2 0 0 2 2 2 2 MIR domain DDE_Tnp_1_6 PF13751.6 EEA05603.1 - 0.26 11.5 1.9 0.33 11.2 0.3 1.9 1 1 1 2 2 2 0 Transposase DDE domain SOUL PF04832.12 EEA05604.1 - 3e-29 102.4 0.0 3.4e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein Aha1_N PF09229.11 EEA05605.1 - 1.4e-14 54.4 1.0 1.4e-14 54.4 1.0 2.3 2 1 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal TPR_2 PF07719.17 EEA05605.1 - 3.4e-07 29.9 0.6 0.032 14.4 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA05605.1 - 1.8e-06 27.5 5.0 0.0078 16.0 0.4 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA05605.1 - 0.00054 19.6 3.6 0.0018 17.9 0.9 2.9 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 EEA05605.1 - 0.0011 19.0 2.1 6.8 7.2 0.3 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 EEA05605.1 - 0.013 15.5 0.2 0.044 13.8 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF5113 PF17140.4 EEA05605.1 - 0.037 13.8 0.2 0.079 12.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) MIT PF04212.18 EEA05605.1 - 0.042 13.9 8.1 0.17 12.0 0.2 3.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EEA05605.1 - 0.044 13.9 1.4 0.24 11.5 0.1 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat PknG_TPR PF16918.5 EEA05605.1 - 0.048 12.4 0.0 0.077 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_6 PF13174.6 EEA05605.1 - 0.13 12.9 2.5 13 6.6 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA05605.1 - 0.24 12.1 0.1 8.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat CTD_bind PF04818.13 EEA05606.1 - 0.089 13.6 0.3 0.44 11.4 0.1 2.4 2 1 0 2 2 2 0 RNA polymerase II-binding domain. OrgA_MxiK PF09482.10 EEA05606.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial type III secretion apparatus protein (OrgA_MxiK) PCNA_N PF00705.18 EEA05607.1 - 3.8e-44 149.5 1.0 9.4e-44 148.2 0.7 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EEA05607.1 - 2.6e-39 134.3 0.0 9.9e-39 132.4 0.0 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EEA05607.1 - 1.6e-07 30.7 0.5 0.00018 20.7 0.2 2.0 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EEA05607.1 - 0.00024 20.6 1.4 0.00035 20.1 1.1 1.3 1 1 0 1 1 1 1 Rad9 DNA_pol3_beta PF00712.19 EEA05607.1 - 0.1 12.7 0.1 16 5.6 0.0 2.8 3 1 0 3 3 3 0 DNA polymerase III beta subunit, N-terminal domain Histone_H2A_C PF16211.5 EEA05608.1 - 3.3e-18 65.1 0.7 6.1e-18 64.3 0.7 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EEA05608.1 - 4.9e-18 65.8 0.0 6.6e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA05608.1 - 9.6e-05 22.6 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YdfA_immunity PF12127.8 EEA05608.1 - 0.05 12.7 0.0 0.057 12.5 0.0 1.0 1 0 0 1 1 1 0 SigmaW regulon antibacterial Pkinase PF00069.25 EEA05609.1 - 4.9e-55 186.7 3.6 1.5e-54 185.1 3.6 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05609.1 - 2.4e-38 131.9 0.4 5.5e-38 130.7 0.4 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Copper-bind PF00127.20 EEA05609.1 - 0.13 12.7 0.3 0.48 10.9 0.3 2.0 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family CheC PF04509.12 EEA05609.1 - 0.18 11.7 0.1 0.51 10.3 0.1 1.8 1 0 0 1 1 1 0 CheC-like family Actin PF00022.19 EEA05611.1 - 1.8e-113 379.2 0.0 2e-113 379.1 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA05611.1 - 0.00013 20.9 0.1 0.016 14.1 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein RCC1_2 PF13540.6 EEA05612.1 - 3.9e-21 74.3 9.1 5.2e-08 32.5 0.3 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EEA05612.1 - 1.6e-19 70.2 7.6 3e-09 37.4 0.0 7.0 8 1 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat DUF5606 PF18347.1 EEA05612.1 - 0.15 12.3 0.0 1.5 9.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5606) SMI1_KNR4 PF09346.10 EEA05612.1 - 5.7 7.3 11.9 10 6.5 0.1 3.9 2 1 2 4 4 4 0 SMI1 / KNR4 family (SUKH-1) DUF5601 PF18151.1 EEA05613.1 - 0.0036 17.6 1.5 0.02 15.2 0.2 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) HAP2-GCS1 PF10699.9 EEA05614.1 - 1.1e-14 54.2 0.3 6.1e-14 51.7 0.0 2.4 2 0 0 2 2 2 1 Male gamete fusion factor His_Phos_1 PF00300.22 EEA05615.1 - 2.4e-12 47.0 0.0 2.9e-12 46.7 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) XRN_N PF03159.18 EEA05616.1 - 9.3e-98 326.5 0.0 2.4e-97 325.1 0.0 1.8 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EEA05616.1 - 1.8e-77 261.2 19.7 2.4e-29 102.6 0.4 4.5 3 1 0 3 3 3 3 Xrn1 helical domain RHH_3 PF12651.7 EEA05616.1 - 0.065 13.2 0.8 5.6 7.0 0.0 2.7 2 0 0 2 2 2 0 Ribbon-helix-helix domain Phosphodiest PF01663.22 EEA05617.1 - 0.00074 19.2 0.3 0.0042 16.7 0.1 1.8 1 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EEA05617.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Sulfatase Globin PF00042.22 EEA05617.1 - 0.044 14.3 0.3 2.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Globin Streptin-Immun PF11083.8 EEA05619.1 - 0.15 12.4 0.5 0.25 11.7 0.1 1.5 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein TM231 PF10149.9 EEA05619.1 - 0.64 9.3 7.5 0.088 12.1 1.7 2.1 1 1 1 2 2 2 0 Transmembrane protein 231 SNF2_N PF00176.23 EEA05621.1 - 4.5e-59 199.9 0.1 4.5e-59 199.9 0.1 2.7 4 0 0 4 4 4 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA05621.1 - 7.7e-19 68.1 0.0 3.6e-18 65.9 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA05621.1 - 4.1e-15 56.2 0.1 2.7e-14 53.5 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Bromodomain PF00439.25 EEA05621.1 - 1.2e-14 54.2 0.0 2.9e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Bromodomain DEAD PF00270.29 EEA05621.1 - 1.1e-06 28.6 0.0 3.1e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EEA05621.1 - 2e-05 24.4 0.0 7e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HDA2-3 PF11496.8 EEA05621.1 - 0.0014 17.9 0.0 0.0065 15.7 0.0 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 NOA36 PF06524.12 EEA05621.1 - 0.029 13.7 19.6 0.073 12.4 19.6 1.6 1 0 0 1 1 1 0 NOA36 protein CLTH PF10607.9 EEA05621.1 - 0.22 11.4 7.9 0.18 11.7 4.8 2.4 3 0 0 3 3 3 0 CTLH/CRA C-terminal to LisH motif domain AAA_22 PF13401.6 EEA05621.1 - 0.23 11.8 0.8 8.6 6.6 0.0 3.3 2 0 0 2 2 2 0 AAA domain DUF2457 PF10446.9 EEA05621.1 - 7.9 5.5 31.7 24 3.9 31.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RDD PF06271.12 EEA05622.1 - 6.2 7.0 9.3 12 6.1 5.4 2.2 2 0 0 2 2 2 0 RDD family BACK PF07707.15 EEA05625.1 - 6.5e-05 23.0 0.6 0.00016 21.7 0.6 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch PNTB PF02233.16 EEA05626.1 - 1.7e-174 581.1 11.3 1.7e-174 581.1 11.3 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EEA05626.1 - 6.2e-64 215.2 2.8 1.1e-63 214.4 2.8 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EEA05626.1 - 1.3e-40 138.9 0.0 2.4e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EEA05626.1 - 1.8e-29 102.0 7.2 1.8e-29 102.0 7.2 3.7 3 2 1 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EEA05626.1 - 6.4e-05 22.4 0.8 0.36 10.2 0.0 2.8 2 1 1 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EEA05626.1 - 0.00093 18.5 0.1 0.0017 17.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EEA05626.1 - 0.068 12.2 0.1 0.1 11.6 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Vma12 PF11712.8 EEA05626.1 - 0.083 13.0 4.4 27 4.8 0.0 3.7 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CSD PF00313.22 EEA05627.1 - 8.6e-24 83.2 0.2 1.1e-23 82.8 0.2 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 EEA05627.1 - 5.5e-06 26.0 0.2 5.5e-06 26.0 0.2 2.5 3 0 0 3 3 3 1 Ribonuclease B OB domain DUF1633 PF07794.11 EEA05627.1 - 0.26 9.4 3.0 0.29 9.3 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) DUF5320 PF17253.2 EEA05627.1 - 1.1 10.3 9.2 1.6 9.8 7.9 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5320) API5 PF05918.11 EEA05627.1 - 6.9 5.4 5.5 7.6 5.2 5.5 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Pro_isomerase PF00160.21 EEA05628.1 - 2e-35 122.4 0.0 1.2e-34 119.8 0.0 2.0 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EEA05628.1 - 4e-18 65.0 0.0 7.4e-18 64.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Romo1 PF10247.9 EEA05629.1 - 4e-17 62.3 8.9 5.2e-17 62.0 8.9 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 DUF2759 PF10958.8 EEA05629.1 - 0.021 14.6 1.7 0.044 13.5 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) PfkB PF00294.24 EEA05630.1 - 3.6e-32 111.9 0.0 1.4e-17 64.0 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase CDC45 PF02724.14 EEA05631.1 - 4.5e-32 111.2 3.3 6.3e-30 104.1 3.3 2.3 1 1 0 1 1 1 1 CDC45-like protein V-ATPase_G PF03179.15 EEA05632.1 - 1.2e-06 29.0 4.3 1.2e-06 28.9 2.0 2.0 1 1 1 2 2 2 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EEA05632.1 - 0.0074 16.4 2.2 0.2 11.7 0.8 2.5 2 1 0 2 2 2 1 ATP synthase B/B' CF(0) RHD3 PF05879.12 EEA05633.1 - 1.7e-78 264.6 25.8 2.3e-71 241.0 13.6 3.2 1 1 1 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EEA05633.1 - 3e-05 23.4 0.7 9.1e-05 21.8 0.7 1.8 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Roc PF08477.13 EEA05633.1 - 6.4e-05 23.2 0.0 0.013 15.8 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EEA05633.1 - 0.0011 19.1 0.2 0.0033 17.5 0.2 1.9 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EEA05633.1 - 0.0014 18.7 0.0 0.0036 17.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EEA05633.1 - 0.022 15.0 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EEA05633.1 - 0.073 13.6 0.1 0.21 12.1 0.1 1.7 1 0 0 1 1 1 0 ABC transporter PIN_2 PF10130.9 EEA05633.1 - 0.21 11.8 1.0 0.66 10.2 0.2 2.1 2 0 0 2 2 2 0 PIN domain TFIIF_beta PF02270.15 EEA05634.1 - 8e-06 25.9 0.1 1.7e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain RPA_C PF08784.11 EEA05634.1 - 0.0035 18.0 1.2 0.0061 17.2 0.2 1.9 2 0 0 2 2 2 1 Replication protein A C terminal Pkinase_Tyr PF07714.17 EEA05635.1 - 2.1e-59 200.9 0.0 2.9e-59 200.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EEA05635.1 - 6.4e-54 183.1 0.0 1e-53 182.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 EEA05635.1 - 8.3e-09 35.8 0.0 2.1e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EEA05635.1 - 1e-06 28.7 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EEA05635.1 - 0.0018 17.1 0.0 0.003 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase MORN PF02493.20 EEA05635.1 - 0.0024 17.7 17.5 0.019 14.8 0.5 4.7 5 0 0 5 5 5 2 MORN repeat Kinase-like PF14531.6 EEA05635.1 - 0.079 12.3 0.1 0.23 10.8 0.0 1.8 2 1 0 2 2 2 0 Kinase-like Pkinase PF00069.25 EEA05636.1 - 9.4e-13 48.1 0.3 2.1e-12 47.0 0.3 1.5 1 0 0 1 1 1 1 Protein kinase domain Cnd1 PF12717.7 EEA05636.1 - 0.002 18.2 6.8 0.0063 16.6 1.6 3.3 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EEA05636.1 - 0.038 14.2 0.0 6 7.4 0.1 3.8 4 0 0 4 4 4 0 HEAT repeat DUF1442 PF07279.11 EEA05636.1 - 0.041 13.2 0.0 0.087 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) Kinase-like PF14531.6 EEA05636.1 - 0.042 13.2 0.0 0.09 12.1 0.0 1.5 1 0 0 1 1 1 0 Kinase-like FH2 PF02181.23 EEA05637.1 - 8.3e-38 130.5 9.9 1.8e-23 83.3 4.4 2.3 2 0 0 2 2 2 2 Formin Homology 2 Domain DUF2989 PF11207.8 EEA05637.1 - 0.017 14.9 0.2 0.043 13.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) CHASE7 PF17151.4 EEA05637.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Periplasmic sensor domain CAMSAP_CH PF11971.8 EEA05637.1 - 0.66 9.9 2.8 4.4 7.2 0.0 3.4 4 0 0 4 4 4 0 CAMSAP CH domain SAP PF02037.27 EEA05638.1 - 2.9e-07 30.1 0.6 2.9e-06 26.9 0.0 2.8 4 0 0 4 4 4 1 SAP domain OST-HTH PF12872.7 EEA05638.1 - 0.047 13.5 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 OST-HTH/LOTUS domain LETM1 PF07766.13 EEA05638.1 - 0.086 12.2 0.3 0.086 12.2 0.3 2.6 2 1 1 3 3 3 0 LETM1-like protein Phage_antitermQ PF06530.12 EEA05638.1 - 0.12 12.3 0.8 2.9 7.8 0.0 2.7 2 0 0 2 2 2 0 Phage antitermination protein Q FAM181 PF15238.6 EEA05638.1 - 0.5 10.2 10.3 0.025 14.4 2.3 2.1 2 0 0 2 2 2 0 FAM181 IL31 PF15209.6 EEA05638.1 - 1.4 8.7 8.6 0.079 12.7 0.5 2.5 3 0 0 3 3 3 0 Interleukin 31 YlbE PF14003.6 EEA05638.1 - 1.4 9.4 4.3 22 5.6 0.4 2.7 2 0 0 2 2 2 0 YlbE-like protein zf-CCCH_4 PF18044.1 EEA05641.1 - 1.2 9.0 4.0 0.81 9.6 1.1 2.0 2 0 0 2 2 2 0 CCCH-type zinc finger CKS PF01111.19 EEA05644.1 - 5.9e-33 112.9 0.5 7.2e-33 112.7 0.5 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DSHCT PF08148.12 EEA05645.1 - 2.4e-48 163.9 0.1 5.5e-48 162.7 0.1 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 EEA05645.1 - 2e-20 73.9 17.8 3.2e-16 60.1 1.8 3.6 3 0 0 3 3 3 2 rRNA-processing arch domain DEAD PF00270.29 EEA05645.1 - 3.4e-16 59.5 0.0 1.2e-15 57.7 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA05645.1 - 0.00015 22.1 3.4 0.00045 20.5 0.0 3.6 3 1 0 3 3 3 1 Helicase conserved C-terminal domain Sushi PF00084.20 EEA05646.1 - 8.7e-07 29.4 0.1 2e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Troponin PF00992.20 EEA05647.1 - 0.086 13.1 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Troponin zf-RING_2 PF13639.6 EEA05649.1 - 4.2e-10 39.8 5.5 7.2e-10 39.0 5.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA05649.1 - 2.4e-09 36.9 6.3 4.2e-09 36.1 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA05649.1 - 5.8e-08 32.9 7.7 2.1e-07 31.1 7.7 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EEA05649.1 - 4.6e-07 29.6 4.7 1e-06 28.5 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA05649.1 - 6.4e-06 25.9 3.3 1.2e-05 25.1 3.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA05649.1 - 7.9e-06 25.8 4.1 1.8e-05 24.7 4.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA05649.1 - 2.7e-05 24.0 3.7 5.5e-05 23.0 3.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA05649.1 - 6e-05 22.8 4.5 0.00012 21.9 4.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EEA05649.1 - 0.00049 20.1 0.5 0.0012 18.9 0.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EEA05649.1 - 0.001 18.6 3.0 0.0021 17.7 3.0 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EEA05649.1 - 0.0012 18.5 2.5 0.003 17.3 2.5 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-RING-like PF08746.11 EEA05649.1 - 0.026 14.8 5.0 0.03 14.6 3.7 1.8 2 0 0 2 2 1 0 RING-like domain FANCL_C PF11793.8 EEA05649.1 - 0.34 11.1 2.6 1.1 9.4 2.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EEA05649.1 - 0.58 10.3 2.5 1.5 9.0 2.5 1.6 1 0 0 1 1 1 0 RING-variant domain UPF0547 PF10571.9 EEA05649.1 - 0.62 10.2 4.1 0.78 9.9 0.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-RING_4 PF14570.6 EEA05649.1 - 0.74 9.7 2.9 1.6 8.6 2.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EEA05649.1 - 0.81 9.9 8.0 0.47 10.6 5.9 1.8 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING Endomucin PF07010.12 EEA05649.1 - 1.1 9.2 9.7 2 8.4 9.7 1.3 1 0 0 1 1 1 0 Endomucin zf-C3H2C3 PF17122.5 EEA05649.1 - 1.8 8.7 4.0 3.3 7.8 4.0 1.5 1 0 0 1 1 1 0 Zinc-finger SHMT PF00464.19 EEA05651.1 - 2e-77 260.4 0.0 6.6e-77 258.8 0.0 1.7 1 1 0 1 1 1 1 Serine hydroxymethyltransferase DUF1664 PF07889.12 EEA05653.1 - 0.83 9.7 6.5 2.5 8.1 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Csm1_N PF18504.1 EEA05654.1 - 0.062 13.6 1.0 0.11 12.8 1.0 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain SHMT PF00464.19 EEA05655.1 - 3.5e-129 430.9 0.0 4.2e-129 430.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase MtrC PF04211.13 EEA05656.1 - 0.029 13.4 0.1 0.079 12.0 0.0 1.7 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit C Autophagy_N PF03986.13 EEA05657.1 - 1.1e-25 90.1 0.1 1.5e-25 89.7 0.1 1.1 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EEA05657.1 - 2.7e-19 69.5 1.6 4.5e-19 68.8 0.9 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EEA05657.1 - 2.8e-11 42.7 0.5 6.5e-11 41.5 0.5 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal zf-Nse PF11789.8 EEA05658.1 - 9.1e-11 41.4 1.4 1.9e-10 40.4 1.4 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 EEA05658.1 - 0.086 13.2 0.1 0.22 11.9 0.1 1.7 1 0 0 1 1 1 0 Ring finger domain GMC_oxred_C PF05199.13 EEA05661.1 - 1.1e-22 81.2 0.0 2.1e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EEA05661.1 - 1.5e-18 67.2 0.0 2.5e-09 36.9 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.6 EEA05661.1 - 9.2e-05 22.6 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EEA05661.1 - 0.00014 21.1 0.0 0.00021 20.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EEA05661.1 - 0.00015 21.1 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EEA05661.1 - 0.00017 20.4 0.1 0.00031 19.6 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EEA05661.1 - 0.0002 20.7 0.0 0.00039 19.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EEA05661.1 - 0.00049 19.3 0.0 0.00069 18.8 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EEA05661.1 - 0.001 19.6 0.2 0.0039 17.7 0.2 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EEA05661.1 - 0.0018 17.6 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GDI PF00996.18 EEA05661.1 - 0.003 16.1 0.0 0.0048 15.5 0.0 1.2 1 0 0 1 1 1 1 GDP dissociation inhibitor GIDA PF01134.22 EEA05661.1 - 0.005 16.0 1.4 0.0084 15.2 1.2 1.5 1 1 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 EEA05661.1 - 0.0073 15.9 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EEA05661.1 - 0.028 13.7 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA05661.1 - 0.034 13.5 0.3 0.051 12.9 0.3 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EEA05661.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-HIT PF04438.16 EEA05663.1 - 0.12 12.3 9.3 0.35 10.8 9.3 1.9 1 0 0 1 1 1 0 HIT zinc finger FAD_binding_3 PF01494.19 EEA05664.1 - 1.6e-46 159.2 0.0 2.6e-46 158.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain MetRS-N PF09635.10 EEA05664.1 - 0.0091 16.5 0.4 0.035 14.6 0.1 2.2 2 0 0 2 2 2 1 MetRS-N binding domain CspB_prodomain PF18425.1 EEA05664.1 - 0.038 14.0 4.0 0.75 9.8 0.0 3.4 3 0 0 3 3 3 0 Csp protease B prodomain NAD_binding_9 PF13454.6 EEA05665.1 - 0.00063 19.8 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EEA05665.1 - 0.00067 19.0 0.0 0.99 8.6 0.0 3.4 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EEA05665.1 - 0.04 14.1 0.0 0.095 12.9 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Peptidase_M16 PF00675.20 EEA05666.1 - 6.2e-10 39.2 0.0 1.2e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA05666.1 - 8.8e-10 38.9 0.3 8e-09 35.8 0.1 2.5 2 0 0 2 2 2 1 Peptidase M16 inactive domain SET PF00856.28 EEA05667.1 - 3.3e-15 56.9 1.9 3.3e-15 56.9 1.9 3.8 3 1 0 3 3 3 1 SET domain PHD PF00628.29 EEA05667.1 - 2.2e-10 40.3 90.4 7.8e-07 28.9 7.6 9.4 7 1 1 8 8 8 6 PHD-finger Bromodomain PF00439.25 EEA05667.1 - 7.4e-10 38.8 1.5 1.1e-08 35.0 1.7 3.2 2 0 0 2 2 2 1 Bromodomain Phage_head_chap PF11113.8 EEA05667.1 - 0.0035 17.4 0.3 0.014 15.5 0.3 2.1 1 0 0 1 1 1 1 Head assembly gene product SNF2_N PF00176.23 EEA05672.1 - 1.8e-62 211.1 3.1 4.9e-62 209.7 3.1 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA05672.1 - 4.5e-17 62.4 0.0 1.7e-16 60.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA05672.1 - 2e-05 24.7 3.8 4e-05 23.7 0.2 3.4 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Sporozoite_P67 PF05642.11 EEA05672.1 - 0.0051 15.0 10.1 0.0089 14.2 10.1 1.3 1 0 0 1 1 1 1 Sporozoite P67 surface antigen SLIDE PF09111.10 EEA05672.1 - 0.021 14.8 0.1 0.021 14.8 0.1 2.8 2 0 0 2 2 2 0 SLIDE LOH1CR12 PF10158.9 EEA05672.1 - 0.073 13.1 0.4 0.95 9.5 0.0 2.8 2 0 0 2 2 2 0 Tumour suppressor protein NOA36 PF06524.12 EEA05672.1 - 7 5.9 25.0 3.4 6.9 22.0 2.0 2 0 0 2 2 2 0 NOA36 protein EMC3_TMCO1 PF01956.16 EEA05673.1 - 3.2e-25 88.8 0.0 3.6e-24 85.4 0.0 2.0 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like PH PF00169.29 EEA05674.1 - 7.7e-05 23.2 1.4 0.00046 20.7 0.1 3.0 3 0 0 3 3 3 1 PH domain Notch PF00066.17 EEA05675.1 - 1.4e-39 134.2 109.1 1.7e-07 31.6 10.9 6.4 4 1 2 6 6 6 6 LNR domain UPRTase PF14681.6 EEA05676.1 - 7.2e-63 211.8 0.0 9.9e-63 211.3 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 EEA05676.1 - 5.8e-47 160.0 0.0 1.3e-46 158.8 0.0 1.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EEA05676.1 - 0.0029 18.1 0.1 0.0093 16.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 EEA05676.1 - 0.0093 15.7 0.1 0.36 10.5 0.0 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase Zeta_toxin PF06414.12 EEA05676.1 - 0.038 13.3 0.0 0.081 12.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin SpoIISA_toxin PF14171.6 EEA05676.1 - 0.079 12.6 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system AAA_33 PF13671.6 EEA05676.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EEA05676.1 - 0.28 10.9 2.2 0.39 10.4 0.2 2.0 2 0 0 2 2 2 0 Cytidylate kinase DnaJ PF00226.31 EEA05677.1 - 1.9e-19 69.5 0.2 3.9e-19 68.5 0.2 1.6 1 0 0 1 1 1 1 DnaJ domain HTH_48 PF17906.1 EEA05677.1 - 0.043 13.9 0.3 15 5.8 0.0 2.7 2 0 0 2 2 2 0 HTH domain in Mos1 transposase Comm PF15957.5 EEA05677.1 - 0.1 13.0 3.0 16 5.8 2.3 2.7 2 1 0 2 2 2 0 Commissureless DUF3522 PF12036.8 EEA05677.1 - 0.2 12.0 3.1 11 6.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3522) LRR_4 PF12799.7 EEA05678.1 - 0.00036 20.8 43.7 0.0048 17.3 7.8 7.8 6 1 2 8 8 8 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EEA05678.1 - 0.059 13.4 11.5 2.5 8.4 0.3 5.5 5 0 0 5 5 5 0 Leucine Rich repeat MINDY_DUB PF04424.13 EEA05678.1 - 0.064 13.3 0.0 0.89 9.6 0.0 2.7 2 1 1 3 3 3 0 MINDY deubiquitinase LRR_8 PF13855.6 EEA05678.1 - 0.58 10.0 14.9 24 4.8 4.3 5.6 4 2 0 4 4 4 0 Leucine rich repeat DUF3213 PF11491.8 EEA05680.1 - 0.069 13.3 1.1 0.98 9.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3213) HABP4_PAI-RBP1 PF04774.15 EEA05681.1 - 0.00062 20.6 1.7 0.00082 20.2 1.7 1.1 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family DnaJ PF00226.31 EEA05682.1 - 1.3e-07 31.6 1.1 2.9e-07 30.5 1.1 1.6 1 0 0 1 1 1 1 DnaJ domain Toxin_9 PF02819.15 EEA05682.1 - 0.41 11.0 4.1 0.82 10.0 4.1 1.4 1 0 0 1 1 1 0 Spider toxin Ribosomal_L1 PF00687.21 EEA05683.1 - 3.9e-43 147.6 4.0 4.8e-43 147.3 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SNRNP27 PF08648.12 EEA05684.1 - 9.6e-23 80.0 0.1 9.6e-23 80.0 0.1 2.2 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins DUF4634 PF15465.6 EEA05684.1 - 0.18 12.1 1.8 0.24 11.7 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) SUI1 PF01253.22 EEA05685.1 - 1.8e-21 76.4 0.1 3.8e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 COPIIcoated_ERV PF07970.12 EEA05686.1 - 5.7e-48 163.7 3.1 8e-48 163.2 3.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EEA05686.1 - 2.2e-21 76.0 1.1 1.5e-20 73.4 0.0 2.7 3 0 0 3 3 3 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) C2 PF00168.30 EEA05687.1 - 4.4e-35 120.1 1.0 4.8e-07 30.0 0.0 5.8 5 0 0 5 5 5 5 C2 domain Ferlin_C PF16165.5 EEA05687.1 - 9.1e-06 25.7 0.0 2.3e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Ferlin C-terminus PTEN_C2 PF10409.9 EEA05687.1 - 0.00024 20.9 0.2 0.0027 17.5 0.0 2.7 3 0 0 3 3 3 1 C2 domain of PTEN tumour-suppressor protein Snf7 PF03357.21 EEA05688.1 - 1.6e-08 34.4 16.5 2.8e-08 33.6 16.5 1.3 1 0 0 1 1 1 1 Snf7 partial_CstF PF15861.5 EEA05688.1 - 4.3 7.2 8.9 0.15 11.9 0.5 2.9 3 0 0 3 3 3 0 Partial cleavage stimulation factor domain Fumerase PF05681.14 EEA05689.1 - 9.5e-77 258.0 0.0 1.3e-76 257.6 0.0 1.2 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.12 EEA05689.1 - 4.3e-74 248.3 0.0 5.9e-74 247.8 0.0 1.2 1 0 0 1 1 1 1 Fumarase C-terminus GTP_EFTU PF00009.27 EEA05690.1 - 1.4e-66 223.8 0.1 2.1e-66 223.2 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EEA05690.1 - 1.3e-31 108.8 0.0 3.5e-31 107.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EEA05690.1 - 1.1e-21 76.6 0.0 2.2e-21 75.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EEA05690.1 - 8.4e-15 54.6 0.0 1.7e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EEA05690.1 - 8.8e-13 48.5 0.1 1.9e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA05690.1 - 0.00043 20.3 0.0 0.00099 19.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EEA05690.1 - 0.015 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain DNA_pol3_delta2 PF13177.6 EEA05691.1 - 3.4e-16 59.5 0.1 5e-15 55.6 0.1 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EEA05691.1 - 5.9e-14 52.6 0.1 1.6e-13 51.2 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EEA05691.1 - 1.7e-11 44.3 0.0 5.9e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_30 PF13604.6 EEA05691.1 - 6.5e-07 29.2 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EEA05691.1 - 5.9e-06 26.3 0.0 2.5e-05 24.3 0.0 2.0 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_19 PF13245.6 EEA05691.1 - 2.7e-05 24.5 0.1 0.00061 20.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA05691.1 - 4e-05 23.6 0.0 9.1e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA05691.1 - 7.6e-05 23.2 0.0 0.00034 21.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EEA05691.1 - 9.8e-05 22.4 0.0 0.00026 21.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EEA05691.1 - 0.00011 22.1 0.0 0.00025 20.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EEA05691.1 - 0.00015 22.0 0.0 0.00046 20.5 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain DUF2075 PF09848.9 EEA05691.1 - 0.00016 21.1 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EEA05691.1 - 0.00019 21.8 0.0 0.0033 17.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EEA05691.1 - 0.00026 21.6 0.0 0.00033 21.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EEA05691.1 - 0.001 18.9 0.0 0.0026 17.5 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 EEA05691.1 - 0.0025 17.6 0.4 0.017 14.9 0.1 2.1 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 EEA05691.1 - 0.0053 16.5 0.0 0.0097 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EEA05691.1 - 0.009 15.5 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 EEA05691.1 - 0.012 15.8 0.0 13 5.9 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain ResIII PF04851.15 EEA05691.1 - 0.012 15.7 0.0 0.11 12.5 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 EEA05691.1 - 0.023 14.6 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EEA05691.1 - 0.025 15.0 0.0 0.077 13.4 0.0 2.0 1 1 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EEA05691.1 - 0.027 14.1 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EEA05691.1 - 0.045 12.9 0.0 0.078 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EEA05691.1 - 0.046 13.1 0.0 0.33 10.3 0.0 2.2 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EEA05691.1 - 0.074 13.6 0.0 0.19 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.23 EEA05691.1 - 0.09 11.5 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain DEAD PF00270.29 EEA05691.1 - 0.094 12.5 0.1 2.6 7.8 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_3 PF07726.11 EEA05691.1 - 0.13 12.1 0.0 0.46 10.3 0.0 1.9 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Lung_7-TM_R PF06814.13 EEA05692.1 - 3.3e-43 148.0 31.3 4.3e-43 147.7 31.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor FixQ PF05545.11 EEA05692.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.8 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ MA3 PF02847.17 EEA05693.1 - 3.2e-19 69.0 3.0 3.6e-19 68.8 0.2 2.7 3 0 0 3 3 3 1 MA3 domain MIF4G PF02854.19 EEA05693.1 - 9.7e-17 61.3 7.3 2.9e-16 59.7 7.3 1.8 1 0 0 1 1 1 1 MIF4G domain Vac14_Fab1_bd PF12755.7 EEA05693.1 - 0.072 13.7 0.8 13 6.5 0.1 2.9 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region LOH1CR12 PF10158.9 EEA05693.1 - 0.16 12.0 1.5 1.1 9.3 0.2 2.6 2 0 0 2 2 2 0 Tumour suppressor protein GST_C_3 PF14497.6 EEA05694.1 - 0.018 15.2 0.0 0.067 13.4 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Proteasome PF00227.26 EEA05695.1 - 1.2e-23 83.6 0.5 2.6e-23 82.5 0.5 1.5 1 1 0 1 1 1 1 Proteasome subunit RACo_linker PF17650.1 EEA05695.1 - 0.021 14.7 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 RACo linker region ECR1_N PF14382.6 EEA05696.1 - 3.5e-10 39.5 0.4 9.3e-10 38.1 0.1 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EEA05696.1 - 4.3e-08 33.4 0.2 9.1e-08 32.3 0.2 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EEA05696.1 - 0.18 12.4 1.7 0.34 11.6 0.1 2.2 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 EXS PF03124.14 EEA05698.1 - 1.4e-69 235.0 29.1 1.4e-69 235.0 29.1 1.5 2 0 0 2 2 2 1 EXS family SPX PF03105.19 EEA05698.1 - 0.0017 18.4 0.9 1.3 8.9 0.0 2.2 2 0 0 2 2 2 2 SPX domain DUF668 PF05003.12 EEA05698.1 - 0.12 12.8 0.0 0.31 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF668) SMC_N PF02463.19 EEA05699.1 - 1.2e-20 73.9 0.0 3.6e-09 36.4 0.0 3.0 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA05699.1 - 0.0019 17.9 0.2 0.0042 16.8 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 EEA05699.1 - 0.041 13.5 1.0 1.2 8.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain AlkA_N PF06029.11 EEA05700.1 - 0.076 13.3 0.1 17 5.7 0.0 2.5 2 1 0 2 2 2 0 AlkA N-terminal domain Aa_trans PF01490.18 EEA05702.1 - 1.5e-07 30.5 38.6 1.5e-07 30.5 38.6 2.2 2 1 0 2 2 2 1 Transmembrane amino acid transporter protein Nuc_recep-AF1 PF11825.8 EEA05703.1 - 0.17 12.0 0.6 0.38 10.8 0.1 1.8 2 0 0 2 2 2 0 Nuclear/hormone receptor activator site AF-1 DUF1077 PF06417.12 EEA05705.1 - 1.1e-30 106.1 2.2 1.3e-30 105.8 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) RIC3 PF15361.6 EEA05705.1 - 0.22 11.9 0.4 5.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 PKD_channel PF08016.12 EEA05705.1 - 0.89 8.2 5.8 1.2 7.8 5.8 1.2 1 0 0 1 1 1 0 Polycystin cation channel Cbl_N PF02262.16 EEA05706.1 - 0.0047 16.9 2.2 0.0047 16.9 2.2 2.9 3 1 1 4 4 4 1 CBL proto-oncogene N-terminal domain 1 tRNA-synt_2e PF02091.15 EEA05706.1 - 0.32 10.2 3.7 0.74 9.0 3.7 1.6 1 0 0 1 1 1 0 Glycyl-tRNA synthetase alpha subunit NifU_N PF01592.16 EEA05707.1 - 1.4e-47 161.0 0.1 1.7e-47 160.7 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Rpr2 PF04032.16 EEA05708.1 - 1.1e-14 54.5 3.3 1.5e-14 54.0 3.3 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Phage_tail_T PF06223.12 EEA05709.1 - 0.032 14.8 0.6 1.1 9.8 0.0 2.6 2 0 0 2 2 2 0 Minor tail protein T Nucleoporin2 PF04096.14 EEA05709.1 - 0.051 13.7 0.6 0.051 13.7 0.6 1.8 2 0 0 2 2 2 0 Nucleoporin autopeptidase IF4E PF01652.18 EEA05710.1 - 3.2e-33 114.8 0.3 4.8e-33 114.2 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PP2C PF00481.21 EEA05711.1 - 9.4e-14 51.7 0.5 3.9e-05 23.4 0.1 3.3 3 0 0 3 3 3 3 Protein phosphatase 2C PP2C_2 PF13672.6 EEA05711.1 - 0.00032 20.4 0.0 0.012 15.3 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C SPRY PF00622.28 EEA05712.1 - 2e-18 66.6 0.5 3.3e-18 65.9 0.5 1.3 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 EEA05712.1 - 0.00052 19.9 1.2 0.00052 19.9 1.2 2.0 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Ubiquitin_5 PF18037.1 EEA05713.1 - 0.94 9.9 7.4 0.25 11.7 4.1 1.8 2 0 0 2 2 2 0 Ubiquitin-like domain DUF3510 PF12022.8 EEA05713.1 - 2.6 8.4 6.4 2.3 8.6 1.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) FAM76 PF16046.5 EEA05713.1 - 8 5.7 11.7 8.9 5.6 11.3 1.3 1 1 0 1 1 1 0 FAM76 protein RRM_1 PF00076.22 EEA05714.1 - 1e-18 66.9 0.0 1.7e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 EEA05714.1 - 7.4e-16 58.6 0.1 2.2e-15 57.0 0.1 1.9 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_7 PF16367.5 EEA05714.1 - 0.0057 16.7 0.0 0.042 14.0 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif SET PF00856.28 EEA05715.1 - 7e-10 39.5 0.1 1.5e-09 38.5 0.1 1.7 1 0 0 1 1 1 1 SET domain Pkinase PF00069.25 EEA05716.1 - 1.3e-39 136.2 0.6 1.8e-39 135.7 0.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05716.1 - 2.5e-19 69.6 0.1 4.6e-19 68.7 0.1 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA05716.1 - 0.00016 20.6 1.0 0.00031 19.7 0.2 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EEA05716.1 - 0.00046 19.6 0.0 0.00071 19.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EEA05716.1 - 0.011 15.1 0.3 0.019 14.3 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA05716.1 - 0.05 13.5 0.0 0.08 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EEA05716.1 - 0.077 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 tRNA-synt_1e PF01406.19 EEA05717.1 - 6e-124 413.3 0.0 8.3e-124 412.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EEA05717.1 - 1.9e-07 30.2 0.2 0.0078 15.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EEA05717.1 - 0.0003 19.2 0.0 0.00085 17.7 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 EEA05717.1 - 0.0005 19.1 0.0 0.0011 17.9 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1f PF01921.18 EEA05717.1 - 0.0019 17.2 0.1 0.085 11.8 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (K) DALR_2 PF09190.11 EEA05717.1 - 0.017 15.6 0.0 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 DALR domain CRAL_TRIO PF00650.20 EEA05718.1 - 3.2e-25 88.7 0.1 7.7e-25 87.5 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EEA05718.1 - 6.1e-07 29.7 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA05718.1 - 2.8e-05 24.2 0.6 6.4e-05 23.0 0.6 1.7 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain Pescadillo_N PF06732.11 EEA05719.1 - 2.2e-100 335.7 4.9 5.1e-100 334.5 4.9 1.6 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 EEA05719.1 - 6.1e-06 26.6 0.7 2.7e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EEA05719.1 - 0.0041 17.5 0.2 0.025 14.9 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RrnaAD PF00398.20 EEA05720.1 - 8.9e-52 175.8 0.0 1.1e-51 175.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EEA05720.1 - 3.7e-09 37.2 0.0 6.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA05720.1 - 4.9e-08 32.9 0.0 8.4e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA05720.1 - 2.5e-06 28.1 0.0 4.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA05720.1 - 1.1e-05 26.0 0.0 2.2e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA05720.1 - 3.3e-05 23.3 0.0 8.1e-05 22.1 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EEA05720.1 - 0.0011 18.5 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 EEA05720.1 - 0.0014 18.4 0.0 0.0038 17.0 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EEA05720.1 - 0.0015 18.4 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA05720.1 - 0.0038 16.7 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.12 EEA05720.1 - 0.022 13.8 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_2 PF00891.18 EEA05720.1 - 0.09 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain UPF0020 PF01170.18 EEA05720.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF43 PF01861.16 EEA05720.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain NodS PF05401.11 EEA05720.1 - 0.14 11.8 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) AAA PF00004.29 EEA05721.1 - 3.5e-43 147.2 0.0 6.6e-43 146.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA05721.1 - 3.2e-11 42.8 0.1 7.3e-11 41.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EEA05721.1 - 3.2e-07 30.6 0.0 6.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA05721.1 - 4.3e-06 26.8 0.0 1.6e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA05721.1 - 8e-06 26.2 0.6 0.0051 17.1 0.6 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA05721.1 - 8.7e-06 26.2 0.5 6.3e-05 23.4 0.5 2.5 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EEA05721.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EEA05721.1 - 0.001 18.3 0.0 0.0026 17.0 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EEA05721.1 - 0.0011 19.1 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA05721.1 - 0.0025 18.4 0.0 0.016 15.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EEA05721.1 - 0.0026 17.5 0.0 0.0056 16.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase PF06745.13 EEA05721.1 - 0.0048 16.3 0.9 0.027 13.8 0.0 2.4 3 0 0 3 3 3 1 KaiC Mg_chelatase PF01078.21 EEA05721.1 - 0.0071 15.8 0.1 0.018 14.4 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI SlyX PF04102.12 EEA05721.1 - 0.0071 16.9 1.1 0.027 15.1 1.1 2.0 1 0 0 1 1 1 1 SlyX AAA_3 PF07726.11 EEA05721.1 - 0.0079 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EEA05721.1 - 0.01 16.1 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA05721.1 - 0.013 15.9 0.0 0.026 14.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EEA05721.1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 EEA05721.1 - 0.015 14.7 0.1 0.15 11.5 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EEA05721.1 - 0.026 14.3 0.1 0.067 12.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA05721.1 - 0.027 14.4 0.0 0.7 9.8 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_7 PF12775.7 EEA05721.1 - 0.03 13.8 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EEA05721.1 - 0.033 14.2 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EEA05721.1 - 0.036 12.7 0.5 1.4 7.5 0.3 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA05721.1 - 0.038 13.6 0.1 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EEA05721.1 - 0.044 13.0 0.0 0.53 9.4 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Parvo_NS1 PF01057.17 EEA05721.1 - 0.045 12.8 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 EEA05721.1 - 0.07 12.8 2.2 0.12 12.0 0.0 2.4 3 1 0 3 3 3 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EEA05721.1 - 0.094 12.6 0.2 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_17 PF13207.6 EEA05721.1 - 0.1 13.0 0.0 0.29 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EEA05721.1 - 0.12 11.6 0.0 0.28 10.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 EEA05721.1 - 0.13 12.1 0.2 0.38 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Sec20 PF03908.13 EEA05722.1 - 6.9e-08 32.3 2.7 8.6e-08 32.0 2.7 1.1 1 0 0 1 1 1 1 Sec20 YpjP PF14005.6 EEA05722.1 - 0.032 14.3 0.2 0.038 14.0 0.2 1.1 1 0 0 1 1 1 0 YpjP-like protein TMEM247 PF15444.6 EEA05722.1 - 0.033 14.2 2.4 0.046 13.8 2.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 Paralemmin PF03285.15 EEA05722.1 - 0.068 12.7 4.1 0.089 12.4 4.1 1.0 1 0 0 1 1 1 0 Paralemmin DUF1640 PF07798.11 EEA05722.1 - 0.12 12.4 4.7 0.18 11.8 4.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) CCDC23 PF15674.5 EEA05722.1 - 0.52 10.3 3.8 0.23 11.5 1.4 1.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 23 Peptidase_C78 PF07910.13 EEA05723.1 - 1.1e-39 136.1 2.6 1.8e-39 135.4 2.6 1.4 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 EEA05723.1 - 0.007 15.8 0.0 0.02 14.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase family C54 Shugoshin_C PF07557.11 EEA05724.1 - 0.015 15.1 0.3 0.015 15.1 0.3 2.3 2 0 0 2 2 2 0 Shugoshin C terminus hDGE_amylase PF14701.6 EEA05725.1 - 2e-128 429.3 4.0 4.5e-128 428.1 4.0 1.6 1 1 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EEA05725.1 - 1e-109 367.0 0.1 1.5e-109 366.5 0.1 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EEA05725.1 - 3.3e-68 230.1 0.5 3.3e-68 230.1 0.5 1.8 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme AMPK1_CBM PF16561.5 EEA05725.1 - 2.7e-17 62.8 7.8 5.6e-15 55.3 5.3 3.3 2 1 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase MIS13 PF08202.11 EEA05725.1 - 0.053 12.8 0.7 0.12 11.7 0.7 1.6 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DUF410 PF04190.13 EEA05726.1 - 1.7e-34 119.8 0.1 2.3e-34 119.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) SIP1 PF04938.12 EEA05727.1 - 8.1e-06 25.7 2.1 1.1e-05 25.3 2.1 1.2 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Thioredoxin PF00085.20 EEA05728.1 - 3.4e-23 81.6 1.6 2.2e-21 75.8 1.3 2.5 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EEA05728.1 - 0.0021 18.5 1.8 0.017 15.5 1.2 2.8 3 1 0 3 3 3 1 Thioredoxin-like domain TraF PF13728.6 EEA05728.1 - 0.01 15.7 0.1 0.38 10.5 0.0 2.2 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 EEA05728.1 - 0.013 15.2 0.1 0.034 13.9 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin OS-D PF03392.13 EEA05728.1 - 0.026 14.6 1.3 0.058 13.5 1.3 1.6 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D Redoxin PF08534.10 EEA05728.1 - 0.079 12.7 0.1 0.31 10.8 0.1 1.9 2 0 0 2 2 2 0 Redoxin AhpC-TSA PF00578.21 EEA05728.1 - 0.1 12.5 0.3 0.32 10.9 0.3 1.8 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 EEA05728.1 - 0.32 11.4 6.8 1.2 9.5 0.1 3.9 2 1 0 4 4 4 0 Thioredoxin-like Peptidase_A22B PF04258.13 EEA05729.1 - 4.9e-74 249.4 13.7 7e-74 248.9 13.7 1.2 1 0 0 1 1 1 1 Signal peptide peptidase PH PF00169.29 EEA05730.1 - 1.3e-11 44.9 0.0 4.4e-07 30.4 0.0 4.1 3 1 0 3 3 3 2 PH domain PH_8 PF15409.6 EEA05730.1 - 0.00041 20.6 0.0 0.0015 18.8 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EEA05730.1 - 0.0016 18.7 0.0 0.0067 16.7 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain Baculo_PEP_C PF04513.12 EEA05731.1 - 3.1e-05 24.1 5.7 0.016 15.2 1.8 2.2 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EEA05731.1 - 0.004 17.2 7.6 1.2 9.1 0.0 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF1664) WXG100 PF06013.12 EEA05731.1 - 0.023 14.9 4.1 0.049 13.9 0.1 2.8 3 1 1 4 4 4 0 Proteins of 100 residues with WXG DUF3106 PF11304.8 EEA05731.1 - 0.12 12.9 3.4 0.26 11.8 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) TEX13 PF15186.6 EEA05731.1 - 0.13 12.0 7.0 0.12 12.0 5.6 1.6 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family DUF5320 PF17253.2 EEA05731.1 - 0.13 13.3 2.3 76 4.5 0.2 3.2 2 1 0 3 3 3 0 Family of unknown function (DUF5320) NPV_P10 PF05531.12 EEA05731.1 - 0.28 11.7 10.6 0.16 12.5 0.5 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.17 EEA05731.1 - 0.36 10.7 16.1 2.1 8.3 0.3 3.4 3 0 0 3 3 3 0 Prefoldin subunit Med4 PF10018.9 EEA05731.1 - 0.87 9.2 10.2 1.3 8.7 3.7 2.5 2 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 CENP-H PF05837.12 EEA05731.1 - 1.1 9.7 10.4 1.1 9.7 0.1 2.6 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Lzipper-MIP1 PF14389.6 EEA05731.1 - 1.4 9.3 9.2 1.3 9.4 5.5 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Fib_alpha PF08702.10 EEA05731.1 - 5.5 7.2 12.7 23 5.2 7.9 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EEA05731.1 - 9.6 6.6 15.6 9.7 6.6 0.2 3.3 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RTT107_BRCT_5 PF16770.5 EEA05732.1 - 4.2e-11 42.6 1.7 4.7e-11 42.4 0.2 1.8 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain FHA PF00498.26 EEA05732.1 - 1.2e-05 25.6 0.0 2.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EEA05732.1 - 0.028 14.7 0.0 0.069 13.5 0.0 1.7 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain TSP_1 PF00090.19 EEA05733.1 - 3.3e-27 94.5 27.2 3.8e-09 36.6 8.7 3.4 3 0 0 3 3 3 3 Thrombospondin type 1 domain EGF PF00008.27 EEA05733.1 - 1.6e-05 25.1 6.7 1.6e-05 25.1 6.7 2.7 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 EEA05733.1 - 0.97 10.2 8.0 0.21 12.3 3.0 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF TSP_1 PF00090.19 EEA05734.1 - 2.5e-12 46.8 42.5 1.2e-06 28.6 5.3 4.0 3 1 0 3 3 3 3 Thrombospondin type 1 domain EGF PF00008.27 EEA05734.1 - 6.3e-06 26.4 10.0 6.3e-06 26.4 10.0 3.5 4 1 0 4 4 4 1 EGF-like domain EGF_2 PF07974.13 EEA05734.1 - 0.00073 19.8 12.5 0.00073 19.8 12.5 2.8 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.7 EEA05734.1 - 0.0054 17.3 7.8 0.0054 17.3 7.8 3.1 3 0 0 3 3 3 1 Human growth factor-like EGF PAW PF04721.17 EEA05735.1 - 0.026 14.3 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW DUF863 PF05904.11 EEA05735.1 - 0.66 8.3 7.7 0.78 8.1 7.7 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) Rhomboid PF01694.22 EEA05737.1 - 6.4e-25 87.9 17.5 6.4e-25 87.9 17.5 2.0 2 1 1 3 3 3 1 Rhomboid family DUF1168 PF06658.12 EEA05737.1 - 0.27 11.1 8.4 0.73 9.7 8.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) LRR_4 PF12799.7 EEA05738.1 - 2e-33 113.8 57.7 1.4e-06 28.5 1.6 7.5 3 1 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EEA05738.1 - 2.5e-21 76.0 25.9 3.9e-07 29.7 2.2 4.5 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 EEA05738.1 - 1.1e-20 73.1 50.6 6.4e-08 32.3 1.3 6.5 3 2 4 7 7 7 6 Leucine rich repeat LRR_6 PF13516.6 EEA05738.1 - 0.0015 18.4 42.2 0.91 9.7 0.1 9.8 11 0 0 11 11 11 4 Leucine Rich repeat LRR_1 PF00560.33 EEA05738.1 - 0.0019 18.5 49.7 0.065 13.8 0.1 10.9 11 1 0 11 11 11 2 Leucine Rich Repeat LRR_2 PF07723.13 EEA05738.1 - 0.028 15.1 7.9 27 5.7 0.2 6.5 8 0 0 8 8 8 0 Leucine Rich Repeat TTRAP PF14203.6 EEA05738.1 - 1.5 8.8 8.5 3.9 7.5 0.0 4.2 4 1 1 5 5 5 0 Putative tranposon-transfer assisting protein bZIP_2 PF07716.15 EEA05739.1 - 0.0001 22.3 7.4 0.0001 22.3 7.4 2.4 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EEA05739.1 - 0.00053 20.0 5.1 0.00053 20.0 5.1 2.3 2 0 0 2 2 2 1 bZIP transcription factor DUF3287 PF11690.8 EEA05739.1 - 0.57 9.9 4.5 1.5 8.6 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) Cnd1 PF12717.7 EEA05740.1 - 0.0028 17.7 0.1 0.0028 17.7 0.1 5.9 5 1 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 E1-E2_ATPase PF00122.20 EEA05741.1 - 8.3e-15 54.8 1.1 1.5e-05 24.6 0.0 4.2 4 0 0 4 4 4 3 E1-E2 ATPase Hydrolase PF00702.26 EEA05741.1 - 6.8e-09 36.3 0.0 0.011 16.0 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 EEA05741.1 - 0.0057 16.4 7.4 0.0057 16.4 7.4 2.8 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EEA05741.1 - 0.014 15.0 0.0 0.014 15.0 0.0 2.0 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus Ribonuc_red_sm PF00268.21 EEA05743.1 - 1.4e-59 201.9 7.5 1.4e-59 201.9 7.5 1.5 2 0 0 2 2 2 1 Ribonucleotide reductase, small chain FrhB_FdhB_C PF04432.13 EEA05743.1 - 0.17 11.7 0.2 0.26 11.1 0.2 1.2 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Ribonuc_red_sm PF00268.21 EEA05744.1 - 5e-106 354.2 2.0 7.1e-106 353.7 2.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain BROMI PF14961.6 EEA05744.1 - 0.0088 13.5 0.2 0.012 13.1 0.2 1.2 1 0 0 1 1 1 1 Broad-minded protein C2 PF00168.30 EEA05746.1 - 2.1e-05 24.8 0.0 0.00011 22.4 0.0 2.3 1 1 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EEA05746.1 - 0.0069 16.0 0.0 0.021 14.4 0.0 1.8 1 0 0 1 1 1 1 CEP76 C2 domain Peptidase_C11 PF03415.14 EEA05747.1 - 4.7e-25 88.7 1.8 1.3e-24 87.3 1.8 1.8 1 1 0 1 1 1 1 Clostripain family EGF_3 PF12947.7 EEA05747.1 - 3.1e-15 56.1 26.2 1.9e-09 37.6 2.1 4.7 4 0 0 4 4 4 2 EGF domain EGF_CA PF07645.15 EEA05747.1 - 1.6e-10 41.0 37.7 1.4e-06 28.4 4.4 6.2 5 2 1 6 6 6 2 Calcium-binding EGF domain cEGF PF12662.7 EEA05747.1 - 3.6e-07 30.0 20.9 0.03 14.3 0.1 5.3 4 1 0 4 4 4 3 Complement Clr-like EGF-like hEGF PF12661.7 EEA05747.1 - 7.8e-07 29.5 21.4 0.0047 17.5 2.3 4.4 3 0 0 3 3 3 2 Human growth factor-like EGF EGF PF00008.27 EEA05747.1 - 6.4e-06 26.4 36.1 0.0038 17.5 3.4 5.1 5 0 0 5 5 5 3 EGF-like domain FXa_inhibition PF14670.6 EEA05747.1 - 0.018 15.3 33.8 0.11 12.8 2.7 5.8 4 1 0 4 4 4 0 Coagulation Factor Xa inhibitory site Asp PF00026.23 EEA05748.1 - 4.2e-50 170.9 0.0 1.7e-38 132.8 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA05748.1 - 4.8e-09 36.7 0.0 1.5e-06 28.5 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Pkinase PF00069.25 EEA05749.1 - 3.2e-78 262.7 0.1 2.3e-77 259.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05749.1 - 3.2e-40 138.1 0.0 7.8e-40 136.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA05749.1 - 4.2e-07 29.6 0.0 1.9e-06 27.4 0.0 2.0 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 EEA05749.1 - 0.027 14.4 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EEA05749.1 - 0.045 13.1 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2691 PF10903.8 EEA05749.1 - 1.5 8.7 8.7 1.5 8.7 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2691) Mic1 PF07035.12 EEA05750.1 - 4e-09 36.4 9.1 7.5e-06 25.7 4.9 2.8 2 0 0 2 2 2 2 Colon cancer-associated protein Mic1-like Got1 PF04178.12 EEA05751.1 - 8.5e-26 90.6 21.6 1.1e-25 90.2 21.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family YrhK PF14145.6 EEA05751.1 - 0.81 9.6 17.8 0.1 12.5 11.3 2.3 2 0 0 2 2 2 0 YrhK-like protein DUF2070 PF09843.9 EEA05751.1 - 2.5 6.3 14.3 3 6.0 14.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Pkinase PF00069.25 EEA05752.1 - 8.1e-61 205.7 0.0 9.8e-61 205.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05752.1 - 2.6e-20 72.8 0.0 3.5e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA05752.1 - 4.4e-07 30.1 0.1 5.1e-06 26.6 0.2 2.4 1 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA05752.1 - 0.017 14.8 0.8 0.1 12.2 0.2 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 EEA05752.1 - 0.038 13.3 0.2 0.063 12.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EEA05752.1 - 0.042 12.6 0.0 0.063 12.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase ABC1 PF03109.16 EEA05752.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 ABC1 family ATP-synt_ab PF00006.25 EEA05753.1 - 4.6e-73 245.4 0.0 7.4e-73 244.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EEA05753.1 - 4.3e-45 153.1 2.6 7.9e-45 152.2 2.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EEA05753.1 - 2.5e-20 72.7 2.0 7.4e-20 71.3 2.0 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EEA05753.1 - 0.0028 17.8 1.5 0.0086 16.2 1.5 1.9 1 1 0 1 1 1 1 HAS barrel domain IML1 PF12257.8 EEA05755.1 - 1.5e-25 89.9 0.3 3.8e-24 85.3 0.3 2.9 1 1 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 Lactamase_B_6 PF16661.5 EEA05756.1 - 4e-17 62.3 0.0 8e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EEA05756.1 - 4.3e-16 59.2 0.0 1.3e-15 57.7 0.0 1.9 1 0 0 1 1 1 1 Beta-Casp domain Ribosomal_L14 PF00238.19 EEA05757.1 - 7.1e-35 119.7 0.0 8.7e-35 119.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e tRNA-synt_2c PF01411.19 EEA05758.1 - 1.1e-192 641.5 0.0 1.5e-192 641.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EEA05758.1 - 7.1e-16 58.0 0.3 2.6e-15 56.2 0.3 2.1 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EEA05758.1 - 0.0021 18.4 0.4 0.0054 17.2 0.4 1.7 1 0 0 1 1 1 1 DHHA1 domain LsmAD PF06741.13 EEA05758.1 - 0.038 14.5 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 LsmAD domain STAT_int PF02865.17 EEA05758.1 - 0.069 13.6 0.1 0.82 10.1 0.1 2.5 2 0 0 2 2 2 0 STAT protein, protein interaction domain AAA PF00004.29 EEA05759.1 - 8.9e-31 107.1 0.0 1.6e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA05759.1 - 0.0003 21.2 0.0 0.00084 19.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EEA05759.1 - 0.00056 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA05759.1 - 0.00088 19.6 0.2 0.0088 16.3 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA05759.1 - 0.0013 19.3 0.0 0.0028 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EEA05759.1 - 0.0026 17.0 0.0 0.0047 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EEA05759.1 - 0.0035 17.1 0.0 0.0092 15.7 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 EEA05759.1 - 0.0089 15.2 0.0 0.019 14.2 0.0 1.5 1 1 0 1 1 1 1 NB-ARC domain TsaE PF02367.17 EEA05759.1 - 0.01 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EEA05759.1 - 0.013 14.9 0.3 2.9 7.2 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_5 PF07728.14 EEA05759.1 - 0.014 15.4 0.0 0.031 14.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EEA05759.1 - 0.016 14.4 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 EEA05759.1 - 0.02 14.5 0.0 0.68 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EEA05759.1 - 0.021 15.0 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA05759.1 - 0.025 14.0 0.0 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DnaB_C PF03796.15 EEA05759.1 - 0.025 13.9 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain NACHT PF05729.12 EEA05759.1 - 0.035 14.0 0.2 0.27 11.1 0.2 2.1 1 1 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.18 EEA05759.1 - 0.039 13.7 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 EEA05759.1 - 0.049 14.0 0.1 0.21 12.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 EEA05759.1 - 0.05 12.9 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EEA05759.1 - 0.077 13.3 0.1 0.43 10.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA05759.1 - 0.094 12.9 0.0 0.19 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 EEA05759.1 - 0.11 12.3 0.1 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein PhoH PF02562.16 EEA05759.1 - 0.12 11.8 0.0 0.96 8.9 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein Sigma54_activat PF00158.26 EEA05759.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EEA05759.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Pkinase PF00069.25 EEA05760.1 - 3.8e-05 23.2 2.6 9.1e-05 21.9 2.6 1.6 1 0 0 1 1 1 1 Protein kinase domain RWD PF05773.22 EEA05760.1 - 0.00029 21.1 0.1 0.0048 17.2 0.0 3.3 2 1 0 2 2 2 1 RWD domain Pkinase PF00069.25 EEA05761.1 - 1.4e-74 250.8 0.0 2.3e-74 250.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05761.1 - 6.7e-37 127.2 0.0 1e-36 126.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA05761.1 - 0.068 12.5 0.2 0.13 11.6 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HEAT PF02985.22 EEA05761.1 - 0.084 13.2 0.0 0.25 11.7 0.0 1.8 1 0 0 1 1 1 0 HEAT repeat APH PF01636.23 EEA05761.1 - 0.2 11.5 0.1 0.4 10.6 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Synaptobrevin PF00957.21 EEA05762.1 - 5.3e-15 55.0 0.4 8.3e-15 54.4 0.4 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EEA05762.1 - 7.3e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain PDEase_I PF00233.19 EEA05763.1 - 2.3e-62 210.8 5.5 6.1e-62 209.5 5.5 1.8 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Zip PF02535.22 EEA05764.1 - 2.5e-26 92.7 22.5 1.9e-25 89.8 22.5 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter SelP_N PF04592.14 EEA05764.1 - 1.6 8.1 6.3 2.5 7.4 6.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Acatn PF13000.7 EEA05766.1 - 8.6e-172 572.5 30.0 1.1e-171 572.1 30.0 1.1 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 MFS_1 PF07690.16 EEA05766.1 - 2.4e-11 43.2 14.4 2.4e-11 43.2 14.4 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily BSD PF03909.17 EEA05767.1 - 2.7e-06 27.3 0.1 7.3e-05 22.7 0.0 3.2 2 0 0 2 2 2 1 BSD domain Vps36_ESCRT-II PF11605.8 EEA05767.1 - 0.11 12.7 2.1 0.27 11.4 0.0 2.6 3 0 0 3 3 3 0 Vacuolar protein sorting protein 36 Vps36 PI_PP_I PF18363.1 EEA05767.1 - 1.1 9.5 11.9 1.1 9.5 0.9 3.6 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain PP2C PF00481.21 EEA05768.1 - 3.3e-18 66.3 0.4 1.1e-10 41.6 0.0 3.4 3 1 0 3 3 3 2 Protein phosphatase 2C Med11 PF10280.9 EEA05768.1 - 0.48 10.9 3.3 1.3 9.5 0.8 2.2 1 1 1 2 2 2 0 Mediator complex protein DUF3644 PF12358.8 EEA05768.1 - 0.87 10.1 4.4 3.1 8.4 1.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3644) Baculo_VP91_N PF08475.10 EEA05770.1 - 0.48 10.1 4.0 0.13 11.9 0.4 1.8 2 0 0 2 2 2 0 Viral capsid protein 91 N-terminal RRM_1 PF00076.22 EEA05771.1 - 4.2e-17 61.7 0.0 6.9e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fip1 PF05182.13 EEA05772.1 - 2.5e-09 36.5 0.0 4.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Fip1 motif COPI_assoc PF08507.10 EEA05774.1 - 2.1e-07 31.0 13.4 3.1e-07 30.5 13.4 1.3 1 0 0 1 1 1 1 COPI associated protein WD40 PF00400.32 EEA05775.1 - 0.00016 22.4 12.9 1.9 9.5 2.1 6.2 5 1 1 6 6 6 2 WD domain, G-beta repeat DUF775 PF05603.12 EEA05776.1 - 3.3e-22 79.0 0.5 5.1e-20 71.9 0.5 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF775) Vps36_ESCRT-II PF11605.8 EEA05777.1 - 0.00035 20.7 0.0 0.00056 20.0 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 EEA05777.1 - 0.0014 18.9 0.0 0.002 18.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial PH domain Mg_trans_NIPA PF05653.14 EEA05778.1 - 5.7e-11 42.1 22.4 8.7e-09 34.9 9.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EEA05778.1 - 5.6e-06 26.6 11.2 5.6e-06 26.6 11.2 4.1 3 2 0 3 3 3 1 EamA-like transporter family DUF4114 PF13448.6 EEA05778.1 - 0.19 12.6 4.7 1.1 10.1 4.7 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4114) MgtE_N PF03448.17 EEA05779.1 - 0.0043 17.6 3.3 0.0084 16.7 1.8 2.0 1 1 1 2 2 2 1 MgtE intracellular N domain ACCA PF03255.14 EEA05779.1 - 0.033 14.1 2.2 0.73 9.7 1.1 2.1 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CCP_MauG PF03150.14 EEA05779.1 - 0.073 13.7 0.2 4.8 7.8 0.2 2.1 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase LRR_6 PF13516.6 EEA05782.1 - 0.48 10.6 4.7 2.1 8.6 0.0 4.2 5 0 0 5 5 5 0 Leucine Rich repeat CLTH PF10607.9 EEA05783.1 - 0.0013 18.6 7.1 0.0013 18.6 7.1 2.4 2 2 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain STATa_Ig PF18214.1 EEA05783.1 - 0.041 13.9 1.4 0.12 12.4 1.4 1.8 1 1 0 1 1 1 0 STATa Immunoglobulin-like domain Adaptin_N PF01602.20 EEA05784.1 - 1.8e-60 205.0 23.6 2.9e-60 204.3 23.6 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EEA05784.1 - 3.9e-44 149.7 0.5 1.5e-43 147.9 0.5 2.1 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EEA05784.1 - 7.6e-43 145.8 2.2 7.6e-43 145.8 2.2 2.0 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 EEA05784.1 - 8.6e-07 29.1 0.1 8.6e-07 29.1 0.1 3.5 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA05784.1 - 0.003 17.9 0.0 0.36 11.2 0.0 3.1 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EEA05784.1 - 0.04 14.2 0.1 1.5 9.3 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat RTP1_C1 PF10363.9 EEA05784.1 - 0.043 14.0 1.4 3 8.0 0.0 3.3 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 CEP44 PF15007.6 EEA05784.1 - 0.12 12.6 0.9 1.8 8.8 0.2 2.9 2 0 0 2 2 2 0 Centrosomal spindle body, CEP44 DUF3730 PF12530.8 EEA05784.1 - 0.15 11.6 4.7 0.53 9.8 4.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3730) DAGAT PF03982.13 EEA05785.1 - 1.3e-26 93.2 0.0 1.9e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase TatD_DNase PF01026.21 EEA05786.1 - 6.5e-33 114.2 0.0 7.2e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase DUF2099 PF09872.9 EEA05786.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2099) MCM PF00493.23 EEA05787.1 - 8.4e-98 325.9 0.1 1.3e-97 325.3 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA05787.1 - 8.7e-37 125.8 0.2 1.6e-36 124.9 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA05787.1 - 2.5e-25 88.7 2.5 7.1e-25 87.3 2.5 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 EEA05787.1 - 3e-14 53.2 1.2 7.5e-14 51.9 1.2 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 EEA05787.1 - 2.7e-06 27.9 0.8 1e-05 26.1 0.1 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA05787.1 - 3.5e-06 26.6 0.0 1.6e-05 24.4 0.0 1.9 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EEA05787.1 - 1.7e-05 24.8 0.0 3.6e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 EEA05787.1 - 0.074 13.7 2.1 0.15 12.7 0.3 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal Desulfoferrod_N PF06397.12 EEA05787.1 - 0.29 10.8 2.1 0.67 9.6 2.1 1.6 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain APG6 PF04111.12 EEA05788.1 - 2.8e-42 144.7 2.2 2.8e-42 144.7 2.2 1.9 2 0 0 2 2 2 1 Apg6 BARA domain CENP-U PF13097.6 EEA05788.1 - 0.043 13.8 0.2 0.076 13.0 0.2 1.3 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit zf-AD PF07776.15 EEA05788.1 - 0.31 11.3 7.8 0.99 9.7 7.8 1.9 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) G-patch_2 PF12656.7 EEA05789.1 - 3.2e-12 46.3 0.0 1.1e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 G-patch domain KN17_SH3 PF18131.1 EEA05789.1 - 0.0013 18.8 0.2 0.0032 17.5 0.2 1.6 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain CPW_WPC PF09717.10 EEA05791.1 - 0.0054 17.7 16.2 3.5 8.7 0.1 5.9 6 0 0 6 6 6 2 Plasmodium falciparum domain of unknown function (CPW_WPC) Antistasin PF02822.14 EEA05791.1 - 0.14 12.8 4.6 19 6.0 0.2 5.4 4 2 1 5 5 5 0 Antistasin family FOG_N PF15888.5 EEA05791.1 - 0.23 11.8 0.1 0.23 11.8 0.1 6.1 5 2 1 6 6 6 0 Folded gastrulation N-terminus DUF4587 PF15248.6 EEA05791.1 - 3.4 8.5 14.2 10 7.0 0.3 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4587) Tme5_EGF_like PF09064.10 EEA05791.1 - 9.1 6.3 12.6 13 5.7 0.1 4.7 4 0 0 4 4 4 0 Thrombomodulin like fifth domain, EGF-like PH PF00169.29 EEA05792.1 - 2.2e-07 31.3 2.3 7.3e-07 29.7 2.3 2.0 1 0 0 1 1 1 1 PH domain PG_binding_4 PF12229.8 EEA05792.1 - 0.0054 17.0 0.2 0.015 15.6 0.2 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Synaptobrevin PF00957.21 EEA05794.1 - 2.4e-18 65.7 1.7 2.7e-18 65.6 0.5 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 EEA05794.1 - 9e-13 48.1 0.4 1.9e-12 47.1 0.4 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Sipho_Gp157 PF05565.11 EEA05794.1 - 0.081 12.9 2.7 2 8.4 0.3 2.3 2 0 0 2 2 2 0 Siphovirus Gp157 GLTSCR1 PF15249.6 EEA05796.1 - 4.7e-07 30.2 1.0 9.6e-07 29.2 0.8 1.8 1 1 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein Na_H_Exchanger PF00999.21 EEA05797.1 - 3e-49 167.8 37.3 4.2e-49 167.3 37.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CHRD PF07452.12 EEA05797.1 - 0.21 12.6 0.6 0.49 11.4 0.6 1.6 1 0 0 1 1 1 0 CHRD domain Na_H_Exchanger PF00999.21 EEA05798.1 - 1.7e-53 181.8 38.3 2.4e-53 181.3 38.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Thioredoxin PF00085.20 EEA05799.1 - 4.5e-54 180.8 0.1 3.2e-26 91.3 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EEA05799.1 - 3.8e-20 72.6 3.1 3.4e-10 40.1 0.2 3.7 3 1 1 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA05799.1 - 5.6e-11 42.3 3.3 1.1e-06 28.3 0.4 3.2 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EEA05799.1 - 6.7e-11 42.6 1.1 1.6e-08 34.9 0.1 3.2 2 2 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EEA05799.1 - 1.3e-08 35.0 0.2 0.3 11.5 0.0 5.0 3 2 1 5 5 5 3 Thioredoxin-like Thioredoxin_7 PF13899.6 EEA05799.1 - 3.9e-08 33.4 0.3 0.01 16.0 0.0 3.6 4 0 0 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EEA05799.1 - 1.1e-05 25.3 0.4 0.072 13.0 0.0 2.7 2 0 0 2 2 2 2 AhpC/TSA family ERp29_N PF07912.13 EEA05799.1 - 1.9e-05 24.8 0.0 0.0018 18.4 0.0 2.7 2 0 0 2 2 2 1 ERp29, N-terminal domain TraF PF13728.6 EEA05799.1 - 0.00072 19.4 0.3 0.69 9.7 0.0 2.7 3 0 0 3 3 3 2 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 EEA05799.1 - 0.0024 17.6 0.0 3.5 7.4 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 EEA05799.1 - 0.0027 17.4 0.1 1.5 8.6 0.0 2.5 2 0 0 2 2 2 2 Redoxin Thioredoxin_3 PF13192.6 EEA05799.1 - 0.0086 16.1 0.6 1.1 9.4 0.0 3.0 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_5 PF13743.6 EEA05799.1 - 0.036 13.7 1.5 13 5.4 0.0 3.2 3 0 0 3 3 3 0 Thioredoxin Malectin PF11721.8 EEA05800.1 - 1.6e-20 73.8 0.4 2.2e-20 73.4 0.4 1.2 1 0 0 1 1 1 1 Malectin domain Citrate_synt PF00285.21 EEA05801.1 - 3.4e-121 404.7 0.0 4e-121 404.5 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain LRR_4 PF12799.7 EEA05802.1 - 1.9e-24 85.3 85.5 1.4e-06 28.6 8.0 6.6 1 1 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA05802.1 - 9.1e-13 47.8 45.8 3e-07 30.1 11.6 5.5 3 3 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EEA05802.1 - 1.6e-06 27.8 25.7 0.0012 18.4 7.0 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EEA05802.1 - 0.1 12.7 40.6 0.6 10.3 0.3 8.0 9 0 0 9 9 9 0 Leucine Rich repeat LRR_3 PF07725.12 EEA05802.1 - 5.5 7.0 0.0 5.5 7.0 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich Repeat MS_channel PF00924.18 EEA05803.1 - 1.1e-17 64.3 1.7 2e-17 63.4 1.7 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel Hist_deacetyl PF00850.19 EEA05804.1 - 1.6e-81 274.2 0.0 1.9e-81 273.9 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Peptidase_M48_N PF16491.5 EEA05805.1 - 2.8e-46 157.7 16.1 2.8e-46 157.7 16.1 2.4 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EEA05805.1 - 8.3e-30 104.0 0.0 1.5e-29 103.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 SprT-like PF10263.9 EEA05805.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 SprT-like family Aminotran_3 PF00202.21 EEA05806.1 - 1e-95 320.8 0.0 1.3e-95 320.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III AAA_26 PF13500.6 EEA05806.1 - 7.5e-31 107.5 0.0 1.2e-30 106.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EEA05806.1 - 0.00076 19.5 0.1 0.0018 18.3 0.1 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Aminotran_1_2 PF00155.21 EEA05806.1 - 0.042 13.0 0.0 0.074 12.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II SpoIIIAH PF12685.7 EEA05808.1 - 0.009 15.9 0.0 0.01 15.7 0.0 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein Zip PF02535.22 EEA05808.1 - 0.14 11.4 0.3 0.14 11.3 0.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Pns11_12 PF17464.2 EEA05808.1 - 0.28 10.9 5.3 0.27 10.9 4.5 1.3 1 1 0 1 1 1 0 Non-structural protein 11 and 12 Pox_A28 PF04584.14 EEA05808.1 - 0.42 10.8 2.6 0.77 9.9 2.6 1.5 1 1 0 1 1 1 0 Poxvirus A28 family Dzip-like_N PF13815.6 EEA05809.1 - 0.0031 17.5 1.2 0.0038 17.2 1.0 1.4 1 1 0 1 1 1 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF4641 PF15483.6 EEA05809.1 - 0.16 11.1 0.1 0.16 11.1 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4641) GrpE PF01025.19 EEA05811.1 - 1.9e-46 157.8 0.5 2.4e-46 157.4 0.5 1.1 1 0 0 1 1 1 1 GrpE Mating_N PF12731.7 EEA05811.1 - 0.023 14.8 0.5 0.042 13.9 0.4 1.5 1 1 0 1 1 1 0 Mating-type protein beta 1 DUF4825 PF16107.5 EEA05811.1 - 0.12 12.5 7.8 0.56 10.4 3.1 2.8 1 1 1 3 3 3 0 Domain of unknown function (DUF4825) AI-2E_transport PF01594.16 EEA05811.1 - 0.15 11.2 0.1 0.63 9.1 0.3 1.8 2 0 0 2 2 2 0 AI-2E family transporter Aida_N PF08910.10 EEA05811.1 - 0.16 12.4 0.6 0.29 11.6 0.6 1.5 1 0 0 1 1 1 0 Aida N-terminus JHY PF15261.6 EEA05811.1 - 0.49 11.1 3.6 1.3 9.8 3.6 1.7 1 1 0 1 1 1 0 Jhy protein DUF2779 PF11074.8 EEA05811.1 - 1.5 9.3 4.9 3.1 8.3 4.8 1.6 1 1 0 1 1 1 0 Domain of unknown function(DUF2779) DnaJ PF00226.31 EEA05812.1 - 4.9e-08 33.0 0.1 6.8e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 EEA05812.1 - 2.6e-05 24.2 0.0 2.6e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 EEA05813.1 - 4.1e-25 87.7 0.7 7.1e-25 86.9 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain TFIIB PF00382.19 EEA05814.1 - 8.6e-24 83.4 0.1 3.2e-11 43.1 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EEA05814.1 - 7.4e-20 71.2 6.3 7.4e-20 71.2 6.3 2.2 3 0 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EEA05814.1 - 5.1e-10 38.7 1.7 1.2e-09 37.5 1.7 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_24 PF13412.6 EEA05814.1 - 0.04 13.5 0.0 0.82 9.3 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding zf-ribbon_3 PF13248.6 EEA05814.1 - 0.17 11.3 3.8 1.1 8.8 3.8 2.2 1 1 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EEA05814.1 - 0.21 11.7 0.6 0.51 10.4 0.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-RRN7 PF11781.8 EEA05814.1 - 0.99 9.2 4.1 11 5.8 4.1 2.4 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Spidroin_N PF16763.5 EEA05814.1 - 7.2 6.7 7.8 0.78 9.8 0.3 2.9 2 1 1 3 3 3 0 Major ampullate spidroin 1, spider silk protein 1, N-term GLTP PF08718.11 EEA05815.1 - 4e-24 85.6 0.0 6e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Methyltr_RsmB-F PF01189.17 EEA05816.1 - 2.1e-35 122.2 0.0 6.6e-33 114.1 0.0 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EEA05816.1 - 0.0028 17.8 0.0 0.006 16.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Transketolase_C PF02780.20 EEA05816.1 - 0.21 11.5 0.0 0.38 10.6 0.0 1.3 1 0 0 1 1 1 0 Transketolase, C-terminal domain Patatin PF01734.22 EEA05817.1 - 7.1e-12 45.9 0.1 1.7e-11 44.7 0.1 1.7 1 1 0 1 1 1 1 Patatin-like phospholipase Tox-PL-2 PF15643.6 EEA05817.1 - 0.041 14.0 0.1 0.2 11.8 0.1 2.2 1 0 0 1 1 1 0 Papain fold toxin 2 DUF5390 PF17365.2 EEA05817.1 - 2.4 8.4 8.2 2.7 8.3 0.1 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5390) Patatin PF01734.22 EEA05818.1 - 1.6e-12 48.0 0.0 4e-12 46.8 0.0 1.6 1 1 0 1 1 1 1 Patatin-like phospholipase ACT_7 PF13840.6 EEA05819.1 - 0.035 13.9 0.1 0.098 12.5 0.1 1.7 1 0 0 1 1 1 0 ACT domain GPS PF01825.21 EEA05819.1 - 0.16 12.5 1.1 0.47 11.0 1.1 1.8 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif BPL_N PF09825.9 EEA05820.1 - 3.8e-22 78.9 0.0 4.4e-22 78.7 0.0 1.0 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal 4HBT PF03061.22 EEA05821.1 - 9.2e-07 29.1 0.0 2.6e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Thioesterase superfamily DTW PF03942.15 EEA05822.1 - 1.4e-11 44.5 0.0 1.7e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 DTW domain 5_nucleotid_C PF02872.18 EEA05823.1 - 8.1e-38 130.1 0.0 1.7e-37 129.1 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EEA05823.1 - 6.7e-12 46.3 0.3 1.2e-11 45.5 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NAC PF01849.18 EEA05824.1 - 4.1e-15 55.5 0.8 9.2e-15 54.4 0.8 1.6 1 0 0 1 1 1 1 NAC domain DUF4263 PF14082.6 EEA05824.1 - 0.0038 17.5 0.6 0.0038 17.5 0.6 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4263) Spc24 PF08286.11 EEA05824.1 - 0.24 11.6 7.2 7.2 6.9 0.1 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 LPP20 PF02169.16 EEA05824.1 - 2.1 8.8 8.9 0.57 10.6 1.7 2.3 2 0 0 2 2 2 0 LPP20 lipoprotein PKI PF02827.16 EEA05824.1 - 4.9 7.4 8.9 0.24 11.6 3.2 1.8 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor DnaJ PF00226.31 EEA05825.1 - 8.9e-23 80.2 1.0 2e-22 79.1 1.0 1.7 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.11 EEA05825.1 - 4.9e-14 52.5 2.1 4.9e-14 52.5 2.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1977) TPR_2 PF07719.17 EEA05825.1 - 0.0025 17.8 0.0 0.014 15.5 0.0 2.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Semialdhyde_dh PF01118.24 EEA05825.1 - 0.08 13.4 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain TSP_1 PF00090.19 EEA05826.1 - 3.9e-61 203.1 175.9 2.8e-10 40.2 5.1 16.8 16 1 0 16 16 16 11 Thrombospondin type 1 domain Notch PF00066.17 EEA05826.1 - 9.5e-28 96.4 185.8 8.6e-08 32.5 17.7 11.7 11 0 0 11 11 11 6 LNR domain TPT PF03151.16 EEA05827.1 - 1e-23 84.1 33.6 1.4e-23 83.7 33.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EEA05827.1 - 2.6e-07 30.9 40.0 5.3e-06 26.6 13.2 2.6 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EEA05827.1 - 5.4e-06 25.8 31.8 8.3e-06 25.2 31.8 1.3 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 EEA05827.1 - 0.12 11.3 30.1 0.67 8.8 30.0 2.3 1 1 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like Peptidase_M16 PF00675.20 EEA05828.1 - 5.3e-48 162.8 0.0 1.7e-47 161.1 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA05828.1 - 3.1e-28 99.0 0.1 2.1e-27 96.3 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain SRR PF07709.11 EEA05828.1 - 0.097 13.1 0.5 22 6.0 0.0 2.9 2 0 0 2 2 2 0 Seven Residue Repeat Kazal_2 PF07648.15 EEA05830.1 - 1.1e-11 44.7 9.5 1.9e-06 27.9 5.1 2.5 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EEA05830.1 - 1.8e-10 40.7 8.1 1.6e-06 28.0 4.3 2.4 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Pentapeptide PF00805.22 EEA05830.1 - 0.12 12.1 5.2 0.39 10.4 0.7 3.3 3 0 0 3 3 3 0 Pentapeptide repeats (8 copies) HARP PF07443.13 EEA05831.1 - 0.056 13.1 0.4 3.7 7.2 0.0 2.9 2 0 0 2 2 2 0 HepA-related protein (HARP) DNA_pol3_a_NI PF14480.6 EEA05831.1 - 0.54 10.3 7.3 1.7 8.7 0.5 4.5 4 0 0 4 4 4 0 DNA polymerase III polC-type N-terminus I ADK PF00406.22 EEA05832.1 - 3.8e-54 182.9 0.0 4.5e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EEA05832.1 - 1.5e-26 93.4 0.3 3.8e-26 92.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EEA05832.1 - 7.1e-16 57.9 0.0 1.4e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EEA05832.1 - 4.7e-07 30.4 0.0 8.5e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA05832.1 - 4.5e-05 23.6 0.0 0.00024 21.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EEA05832.1 - 6.8e-05 22.2 0.0 0.00019 20.8 0.0 1.6 1 1 0 1 1 1 1 Zeta toxin Hydin_ADK PF17213.3 EEA05832.1 - 0.0065 16.8 0.1 0.14 12.4 0.0 2.1 1 1 1 2 2 2 1 Hydin Adenylate kinase-like domain Thymidylate_kin PF02223.17 EEA05832.1 - 0.0076 15.9 0.0 0.095 12.4 0.0 2.3 2 1 1 3 3 3 1 Thymidylate kinase RNA_helicase PF00910.22 EEA05832.1 - 0.015 15.7 0.0 2.6 8.5 0.0 2.3 1 1 0 2 2 2 0 RNA helicase Cytidylate_kin PF02224.18 EEA05832.1 - 0.017 14.8 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase 6PF2K PF01591.18 EEA05832.1 - 0.017 14.4 0.0 5.1 6.3 0.0 2.3 1 1 1 2 2 2 0 6-phosphofructo-2-kinase AAA_22 PF13401.6 EEA05832.1 - 0.06 13.6 0.1 0.13 12.6 0.0 1.7 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EEA05832.1 - 0.071 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Pro_isomerase PF00160.21 EEA05833.1 - 2.4e-46 157.9 0.0 2.8e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lon_C PF05362.13 EEA05834.1 - 1.9e-63 213.7 0.0 7.3e-63 211.8 0.0 2.0 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EEA05834.1 - 5.8e-24 85.1 0.0 5.8e-24 85.1 0.0 2.9 1 1 1 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EEA05834.1 - 3.3e-23 82.6 1.1 1.4e-22 80.5 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 EEA05834.1 - 1.1e-12 47.9 0.0 2.1e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EEA05834.1 - 3.6e-11 43.2 0.0 1.9e-10 40.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EEA05834.1 - 2.6e-05 24.2 3.8 5e-05 23.3 0.0 3.3 3 2 0 3 3 3 1 Rad17 P-loop domain AAA_22 PF13401.6 EEA05834.1 - 5.4e-05 23.5 2.9 0.00045 20.5 0.1 3.5 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA05834.1 - 5.6e-05 23.6 0.1 0.00021 21.7 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 EEA05834.1 - 0.00034 20.8 0.2 0.0031 17.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) BH3 PF15285.6 EEA05834.1 - 0.00054 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting AAA_14 PF13173.6 EEA05834.1 - 0.0025 17.9 8.4 0.0047 17.0 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EEA05834.1 - 0.0032 17.2 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EEA05834.1 - 0.0038 17.7 0.0 0.0038 17.7 0.0 3.2 3 1 0 3 3 1 1 ABC transporter AAA_3 PF07726.11 EEA05834.1 - 0.0061 16.4 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EEA05834.1 - 0.0099 16.3 0.0 0.04 14.3 0.0 2.1 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 EEA05834.1 - 0.018 14.8 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EEA05834.1 - 0.018 14.6 0.0 0.054 13.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region SMC_N PF02463.19 EEA05834.1 - 0.021 14.3 0.1 0.021 14.3 0.1 2.3 3 0 0 3 3 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 EEA05834.1 - 0.024 14.5 0.4 0.079 12.9 0.0 2.1 2 0 0 2 2 1 0 NACHT domain AAA_19 PF13245.6 EEA05834.1 - 0.026 14.9 0.0 0.084 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA05834.1 - 0.028 14.9 2.6 0.059 13.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EEA05834.1 - 0.034 13.9 0.0 0.09 12.5 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EEA05834.1 - 0.04 13.8 0.0 0.24 11.3 0.0 2.3 1 1 1 2 2 2 0 NTPase RuvB_N PF05496.12 EEA05834.1 - 0.05 13.4 0.1 1.9 8.2 0.0 3.1 3 1 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EEA05834.1 - 0.063 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EEA05834.1 - 0.075 12.8 0.0 0.075 12.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 EEA05834.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 EEA05834.1 - 0.15 12.3 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EEA05834.1 - 0.16 12.1 0.4 7.6 6.7 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.6 EEA05834.1 - 0.73 10.3 0.0 0.73 10.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain vATP-synt_AC39 PF01992.16 EEA05835.1 - 1.2e-92 311.0 8.6 1.5e-92 310.7 8.6 1.1 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit DUF2682 PF10909.8 EEA05835.1 - 0.058 13.9 0.3 0.29 11.7 0.3 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2682) DUF3605 PF12239.8 EEA05835.1 - 0.085 13.2 0.3 0.18 12.1 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3605) DER1 PF04511.15 EEA05836.1 - 8.3e-47 159.6 16.9 9.4e-47 159.4 16.9 1.0 1 0 0 1 1 1 1 Der1-like family WD40 PF00400.32 EEA05838.1 - 4.4e-11 43.2 4.2 0.0045 17.8 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA05838.1 - 0.025 14.8 0.1 26 5.2 0.0 4.0 2 1 2 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain zf-HC5HC2H_2 PF13832.6 EEA05839.1 - 1.9e-17 63.4 49.4 3.7e-07 30.3 0.2 7.2 5 3 1 7 7 7 4 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA05839.1 - 2.7e-06 27.6 19.9 0.00014 22.0 3.9 7.4 5 1 3 8 8 8 2 PHD-like zinc-binding domain PHD_2 PF13831.6 EEA05839.1 - 3e-06 26.7 35.9 1.3e-05 24.7 5.9 4.6 4 0 0 4 4 4 2 PHD-finger PHD PF00628.29 EEA05839.1 - 4.7e-05 23.2 8.6 4.7e-05 23.2 8.6 6.1 8 0 0 8 8 8 3 PHD-finger TFIIS_M PF07500.14 EEA05840.1 - 3.2e-15 56.6 0.1 3.2e-15 56.6 0.1 2.4 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain DUF1168 PF06658.12 EEA05841.1 - 9.4e-19 67.6 10.9 1.2e-18 67.3 10.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) U79_P34 PF03064.16 EEA05841.1 - 0.028 13.8 11.0 0.037 13.4 11.0 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 RRM_1 PF00076.22 EEA05842.1 - 1.4e-26 92.0 0.5 4.2e-12 45.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA05842.1 - 1.2e-10 41.3 0.4 0.00036 20.6 0.0 3.1 2 2 0 2 2 2 2 RNA recognition motif Laminin_G_1 PF00054.23 EEA05842.1 - 0.006 16.8 0.0 0.42 10.8 0.0 2.2 2 0 0 2 2 2 1 Laminin G domain Nup35_RRM PF05172.13 EEA05842.1 - 0.014 15.3 0.2 0.95 9.5 0.1 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EEA05842.1 - 0.035 13.8 0.2 8.5 6.1 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain Nup35_RRM_2 PF14605.6 EEA05842.1 - 0.07 13.1 0.1 4 7.5 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Spo7_2_N PF15407.6 EEA05842.1 - 0.087 12.5 0.1 1.3 8.7 0.0 2.5 3 0 0 3 3 3 0 Sporulation protein family 7 zf-Tim10_DDP PF02953.15 EEA05843.1 - 1.7e-10 40.4 0.7 2.1e-10 40.1 0.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 EEA05843.1 - 0.022 14.5 0.7 0.024 14.3 0.7 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Glyco_transf_8 PF01501.20 EEA05844.1 - 1e-31 110.4 4.0 1.4e-31 110.0 4.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EEA05844.1 - 0.00015 21.3 1.0 0.00021 20.8 1.0 1.2 1 0 0 1 1 1 1 Glucosyltransferase 24 Sod_Fe_C PF02777.18 EEA05845.1 - 3.8e-37 126.6 2.1 4.6e-37 126.3 0.2 2.0 3 0 0 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EEA05845.1 - 1.1e-28 99.5 0.9 2.7e-28 98.2 0.2 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Proteasome PF00227.26 EEA05846.1 - 2.5e-14 53.2 0.2 9.6e-11 41.5 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit DASH_Dad1 PF08649.10 EEA05847.1 - 0.056 13.6 1.6 8.8 6.6 0.3 4.5 3 0 0 3 3 3 0 DASH complex subunit Dad1 AMP-binding PF00501.28 EEA05848.1 - 1.3e-67 228.3 0.0 1.6e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA05848.1 - 0.0023 18.8 0.0 0.0048 17.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Mito_carr PF00153.27 EEA05849.1 - 5.2e-32 109.6 3.7 2.6e-16 59.3 0.1 4.4 2 2 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA05849.1 - 0.0022 17.2 0.0 0.58 9.3 0.1 2.4 3 0 0 3 3 3 2 Gammaproteobacterial serine protease Adenosine_kin PF04008.14 EEA05849.1 - 0.17 11.7 0.0 6.7 6.5 0.0 2.2 2 0 0 2 2 2 0 Adenosine specific kinase Pkinase_Tyr PF07714.17 EEA05850.1 - 5.4e-18 65.2 0.0 2.6e-14 53.1 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EEA05850.1 - 2.6e-15 56.5 0.0 7.6e-06 25.5 0.0 3.8 3 1 0 3 3 3 3 Protein kinase domain SAM_1 PF00536.30 EEA05850.1 - 6.5e-05 23.3 0.1 0.00034 21.0 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EEA05850.1 - 0.00029 20.9 0.0 0.00073 19.6 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MORN PF02493.20 EEA05850.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 MORN repeat Histone PF00125.24 EEA05851.1 - 1.1e-16 61.4 1.7 1.3e-16 61.1 1.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA05851.1 - 3.8e-06 27.1 0.9 8.9e-06 25.9 0.9 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EEA05851.1 - 0.0027 18.2 0.0 0.0048 17.4 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1804 PF08822.11 EEA05851.1 - 0.017 15.1 0.8 0.021 14.8 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) YscO-like PF16789.5 EEA05851.1 - 0.018 15.1 1.0 0.021 14.9 1.0 1.2 1 0 0 1 1 1 0 YscO-like protein FliJ PF02050.16 EEA05851.1 - 0.036 14.3 2.1 0.048 13.9 2.1 1.1 1 0 0 1 1 1 0 Flagellar FliJ protein Actin PF00022.19 EEA05852.1 - 4.7e-146 486.6 0.0 1.8e-145 484.6 0.0 1.7 1 1 0 1 1 1 1 Actin Glycos_transf_1 PF00534.20 EEA05853.1 - 4.1e-38 130.6 0.0 1e-37 129.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA05853.1 - 2.5e-28 99.2 0.0 4.7e-28 98.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EEA05853.1 - 1.3e-22 80.6 0.2 1.1e-21 77.6 0.1 2.4 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EEA05853.1 - 4.2e-15 56.5 0.0 9.4e-15 55.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 EEA05853.1 - 1.3e-13 51.3 0.1 3.8e-07 30.1 0.0 2.7 1 1 1 2 2 2 2 Starch synthase catalytic domain Alpha-amylase_C PF02806.18 EEA05853.1 - 8.6e-06 26.1 0.2 3.4e-05 24.2 0.2 2.1 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EEA05853.1 - 2.4e-05 24.1 0.4 5.2e-05 23.0 0.4 1.5 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_trans_1_2 PF13524.6 EEA05853.1 - 0.017 15.5 0.0 0.048 14.1 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 Oest_recep PF02159.15 EEA05853.1 - 0.066 13.7 0.2 0.34 11.4 0.3 2.1 2 0 0 2 2 2 0 Oestrogen receptor CBM_48 PF02922.18 EEA05853.1 - 0.067 13.6 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) TPR_1 PF00515.28 EEA05854.1 - 4.9e-06 26.1 0.1 0.0078 16.0 0.0 3.5 2 1 0 2 2 2 2 Tetratricopeptide repeat putAbiC PF16872.5 EEA05854.1 - 0.00038 21.1 9.3 0.0025 18.4 1.2 4.0 2 0 0 2 2 2 1 Putative phage abortive infection protein TPR_2 PF07719.17 EEA05854.1 - 0.0012 18.8 0.0 2.5 8.4 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Arm PF00514.23 EEA05854.1 - 0.016 15.3 1.0 23 5.2 0.0 4.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF2316 PF10078.9 EEA05854.1 - 0.089 13.0 0.1 0.32 11.3 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) TPR_8 PF13181.6 EEA05854.1 - 0.12 12.7 0.1 13 6.3 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat K1 PF02960.14 EEA05855.1 - 0.35 11.0 0.1 0.35 11.0 0.1 2.5 3 1 1 4 4 4 0 K1 glycoprotein VTC PF09359.10 EEA05857.1 - 4.1e-91 305.2 2.9 4.1e-91 305.2 2.9 1.8 2 0 0 2 2 2 1 VTC domain DUF202 PF02656.15 EEA05857.1 - 7.8e-05 23.0 2.0 0.00014 22.3 0.2 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF202) DUF5085 PF16895.5 EEA05857.1 - 0.0013 19.1 0.5 0.024 15.0 0.2 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5085) SPX PF03105.19 EEA05857.1 - 0.0085 16.1 0.3 0.024 14.6 0.3 1.7 1 0 0 1 1 1 1 SPX domain Abhydrolase_2 PF02230.16 EEA05858.1 - 9.9e-14 51.7 0.0 1.5e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EEA05858.1 - 0.0065 15.8 0.0 0.0099 15.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 GSCFA PF08885.11 EEA05858.1 - 0.085 12.5 0.1 4.9 6.7 0.0 2.2 2 0 0 2 2 2 0 GSCFA family Abhydrolase_3 PF07859.13 EEA05858.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold TPR_2 PF07719.17 EEA05859.1 - 0.12 12.6 0.2 0.39 11.0 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat XhlA PF10779.9 EEA05860.1 - 8.4 6.7 6.8 1 9.6 1.8 2.1 2 0 0 2 2 2 0 Haemolysin XhlA TMA7 PF09072.10 EEA05862.1 - 2e-08 35.0 13.3 2.1e-08 34.9 13.3 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Herpes_IR6 PF06307.12 EEA05863.1 - 0.13 11.8 0.1 0.31 10.5 0.1 1.6 2 0 0 2 2 2 0 Herpesvirus IR6 protein GTP_EFTU PF00009.27 EEA05864.1 - 7.7e-52 175.7 0.2 1.5e-51 174.7 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EEA05864.1 - 1.2e-41 141.5 0.1 3e-41 140.2 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EEA05864.1 - 2.1e-15 56.9 1.0 7.8e-15 55.0 0.6 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA05864.1 - 4.7e-05 23.4 0.0 0.0018 18.3 0.0 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EEA05864.1 - 0.0017 18.2 0.6 0.0074 16.2 0.6 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 FlpD PF02662.16 EEA05864.1 - 0.055 13.5 0.1 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit G-alpha PF00503.20 EEA05864.1 - 0.13 11.4 0.2 0.91 8.6 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit VPS13_C PF16909.5 EEA05865.1 - 0.065 13.0 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Glutaredoxin PF00462.24 EEA05866.1 - 3.8e-13 49.4 0.0 4.8e-12 45.9 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EEA05866.1 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EEA05866.1 - 0.012 15.0 0.2 0.015 14.7 0.2 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family GTP_EFTU PF00009.27 EEA05867.1 - 3.3e-50 170.3 0.1 5.7e-50 169.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EEA05867.1 - 8.7e-16 57.7 0.0 2.7e-15 56.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EEA05867.1 - 5.4e-06 26.4 0.0 1.8e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EEA05867.1 - 0.0017 18.7 0.0 0.0042 17.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Vps54 PF07928.12 EEA05868.1 - 8.1e-11 42.5 0.3 5.1e-10 39.9 0.3 2.6 1 1 0 1 1 1 1 Vps54-like protein Terminase_6C PF17289.2 EEA05870.1 - 0.0082 16.2 0.8 0.019 15.1 0.8 1.5 1 0 0 1 1 1 1 Terminase RNaseH-like domain Phage_int_SAM_6 PF18644.1 EEA05871.1 - 0.0019 18.2 2.6 0.0019 18.2 2.6 1.9 1 1 1 2 2 2 1 Phage integrase SAM-like domain Mem_trans PF03547.18 EEA05871.1 - 2.6 6.3 4.1 7.1 4.9 4.1 1.8 1 1 0 1 1 1 0 Membrane transport protein CAP18_C PF12153.8 EEA05872.1 - 0.00077 19.3 0.2 0.0018 18.1 0.2 1.6 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) PH PF00169.29 EEA05873.1 - 7.3e-05 23.2 1.5 7.3e-05 23.2 1.5 2.1 2 1 0 2 2 2 1 PH domain Mito_carr PF00153.27 EEA05876.1 - 1e-39 134.3 1.7 1.3e-15 57.1 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein ASFV_L11L PF05293.11 EEA05876.1 - 1.1 9.6 7.0 0.44 10.9 0.2 3.4 2 1 2 4 4 4 0 African swine fever virus (ASFV) L11L protein Evr1_Alr PF04777.13 EEA05877.1 - 9.4e-21 74.2 0.1 1.3e-20 73.8 0.1 1.2 1 0 0 1 1 1 1 Erv1 / Alr family Med27 PF11571.8 EEA05877.1 - 0.018 15.4 0.7 0.13 12.7 0.1 2.2 1 1 1 2 2 2 0 Mediator complex subunit 27 Biopterin_H PF00351.21 EEA05877.1 - 0.13 11.3 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase SCP_3 PF17844.1 EEA05877.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial SCP ortholog SNF2_N PF00176.23 EEA05878.1 - 2.7e-66 223.7 0.2 6.6e-66 222.4 0.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EEA05878.1 - 2.6e-31 108.0 5.8 2.6e-31 108.0 5.8 3.4 2 0 0 2 2 2 1 SLIDE Helicase_C PF00271.31 EEA05878.1 - 5.5e-19 68.6 0.0 5.5e-19 68.6 0.0 3.3 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA05878.1 - 8.3e-12 45.4 0.0 8.3e-12 45.4 0.0 4.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA05878.1 - 0.00022 21.1 0.0 0.00059 19.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA05878.1 - 0.034 14.4 0.1 0.2 11.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain RabGAP-TBC PF00566.18 EEA05879.1 - 7.8e-24 84.5 1.8 1.2e-23 83.9 1.8 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PX PF00787.24 EEA05880.1 - 6.9e-23 80.8 0.1 1.7e-22 79.6 0.1 1.6 1 0 0 1 1 1 1 PX domain FeThRed_A PF02941.15 EEA05880.1 - 0.066 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase variable alpha chain Peptidase_C1 PF00112.23 EEA05881.1 - 1.6e-31 110.1 11.4 7.4e-29 101.4 9.4 3.2 2 1 0 2 2 2 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EEA05881.1 - 4.8e-11 43.0 7.5 5e-11 42.9 1.3 3.3 2 1 0 2 2 2 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EEA05881.1 - 0.088 11.6 0.4 0.15 10.8 0.4 1.3 1 0 0 1 1 1 0 Peptidase C1-like family PEP-utilizers_C PF02896.18 EEA05881.1 - 0.093 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain Gp-FAR-1 PF05823.12 EEA05882.1 - 0.017 15.5 3.5 0.017 15.5 3.5 1.6 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) NPV_P10 PF05531.12 EEA05882.1 - 0.028 14.9 0.9 0.043 14.3 0.2 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein pRN1_helical PF13010.6 EEA05882.1 - 0.17 11.8 6.9 0.13 12.2 4.7 1.8 1 1 1 2 2 2 0 Primase helical domain SKA2 PF16740.5 EEA05882.1 - 0.22 11.3 6.5 1.3 8.8 2.6 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 GIDA_assoc PF13932.6 EEA05882.1 - 0.72 10.0 8.8 1.1 9.4 8.8 1.3 1 0 0 1 1 1 0 GidA associated domain Allexi_40kDa PF05549.11 EEA05882.1 - 0.79 9.2 6.5 0.38 10.2 0.7 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein Med4 PF10018.9 EEA05882.1 - 1.4 8.6 10.9 0.059 13.0 2.5 2.1 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF16 PF01519.16 EEA05882.1 - 2.3 8.7 9.4 10 6.7 8.9 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 HSP70 PF00012.20 EEA05882.1 - 2.6 6.1 8.2 3.2 5.8 8.2 1.2 1 0 0 1 1 1 0 Hsp70 protein LMBR1 PF04791.16 EEA05882.1 - 3.3 6.5 7.5 3.7 6.3 7.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PIGA PF08288.12 EEA05883.1 - 1.9e-40 137.3 1.5 4.3e-40 136.2 1.5 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EEA05883.1 - 2.2e-28 99.4 0.1 3e-28 99.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EEA05883.1 - 6.3e-24 84.4 0.0 9.8e-24 83.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA05883.1 - 1.4e-19 70.8 0.0 2.8e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EEA05883.1 - 3.9e-08 33.9 0.0 5.6e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EEA05883.1 - 0.0026 17.8 0.1 0.0043 17.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like SET PF00856.28 EEA05885.1 - 1e-10 42.3 0.0 3.3e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 SET domain DNA_RNApol_7kD PF03604.13 EEA05885.1 - 0.027 14.1 2.6 0.069 12.8 2.6 1.7 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DHHC PF01529.20 EEA05886.1 - 1.1e-25 90.2 18.0 1.1e-25 90.2 18.0 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF2207 PF09972.9 EEA05886.1 - 5.7 5.6 7.7 6.6 5.4 1.5 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Cyclin_N PF00134.23 EEA05887.1 - 3.3e-12 46.2 1.6 3.3e-12 46.2 1.6 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA05887.1 - 3.6e-08 33.5 2.9 6e-08 32.8 1.3 2.3 2 1 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EEA05887.1 - 0.06 13.4 1.6 0.11 12.5 0.3 2.0 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Glyco_transf_22 PF03901.17 EEA05889.1 - 4.2e-70 237.1 63.1 5.2e-70 236.8 63.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Kelch_4 PF13418.6 EEA05890.1 - 3.5e-44 148.6 6.0 8e-10 38.6 0.0 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EEA05890.1 - 8.1e-36 121.5 3.2 5.8e-06 26.2 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EEA05890.1 - 6e-30 102.6 4.7 6.8e-08 32.0 0.1 6.5 6 1 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EEA05890.1 - 2.2e-29 101.2 5.1 3.7e-07 30.2 0.0 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EEA05890.1 - 1.1e-26 91.8 5.0 1.3e-07 31.3 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EEA05890.1 - 2.4e-25 87.9 6.4 8.6e-05 22.7 0.2 6.2 5 1 1 6 6 6 5 Kelch motif BTB PF00651.31 EEA05890.1 - 4.3e-21 75.2 3.1 7e-21 74.5 1.7 2.0 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EEA05890.1 - 0.0016 18.5 0.2 0.21 11.7 0.0 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch CorA PF01544.18 EEA05891.1 - 0.00063 19.1 9.1 0.011 15.1 3.8 2.7 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein PS_Dcarbxylase PF02666.15 EEA05891.1 - 0.021 14.4 0.0 0.032 13.8 0.0 1.4 1 1 0 1 1 1 0 Phosphatidylserine decarboxylase Med9 PF07544.13 EEA05891.1 - 0.2 11.8 1.7 0.41 10.8 0.1 2.3 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 SAC3_GANP PF03399.16 EEA05892.1 - 1.7e-30 106.4 2.5 1.4e-29 103.4 2.5 2.3 1 1 0 1 1 1 1 SAC3/GANP family MRP-L46 PF11788.8 EEA05892.1 - 0.76 10.5 4.0 1.5 9.6 0.1 3.1 3 0 0 3 3 3 0 39S mitochondrial ribosomal protein L46 MMR_HSR1_Xtn PF16897.5 EEA05893.1 - 9.4e-42 141.3 0.8 1.5e-41 140.7 0.8 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EEA05893.1 - 6.9e-22 77.3 0.1 1.3e-21 76.4 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EEA05893.1 - 3.4e-21 75.4 0.0 1.1e-20 73.8 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA05893.1 - 1.4e-11 44.2 0.2 8.2e-11 41.7 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EEA05893.1 - 0.00039 19.5 0.3 0.0024 16.9 0.1 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EEA05893.1 - 0.00051 20.1 0.1 0.96 9.5 0.2 2.4 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 EEA05893.1 - 0.08 12.8 1.1 0.87 9.5 0.1 2.8 3 0 0 3 3 3 0 RsgA GTPase SRPRB PF09439.10 EEA05893.1 - 0.09 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 EEA05893.1 - 0.16 12.2 0.2 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EEA05893.1 - 0.2 11.9 0.2 0.54 10.5 0.1 1.7 2 0 0 2 2 2 0 AAA domain Thioredoxin PF00085.20 EEA05894.1 - 6.7e-06 26.0 0.0 8.3e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Rad51 PF08423.11 EEA05895.1 - 4.7e-29 101.4 0.0 4.2e-28 98.3 0.0 1.9 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 EEA05895.1 - 6.8e-07 28.9 3.8 1.1e-06 28.1 3.1 1.8 2 1 0 2 2 2 1 KaiC AAA_25 PF13481.6 EEA05895.1 - 1.2e-06 28.3 0.0 1.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA05895.1 - 3.2e-05 24.2 0.0 0.0001 22.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA05895.1 - 6.6e-05 22.7 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA05895.1 - 0.002 18.7 2.1 0.0077 16.8 2.1 2.0 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EEA05895.1 - 0.025 14.3 0.3 2.9 7.6 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 EEA05895.1 - 0.03 14.8 0.6 0.27 11.7 0.2 2.2 2 0 0 2 2 2 0 AAA domain RecA PF00154.21 EEA05895.1 - 0.059 12.8 0.4 0.42 10.0 0.0 2.1 1 1 1 2 2 2 0 recA bacterial DNA recombination protein DnaB_C PF03796.15 EEA05895.1 - 0.061 12.7 1.2 0.15 11.4 1.2 1.7 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain AAA PF00004.29 EEA05895.1 - 0.083 13.3 0.6 0.29 11.6 0.6 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EEA05895.1 - 0.085 12.8 0.1 0.36 10.7 0.1 1.8 1 1 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 EEA05895.1 - 0.09 12.9 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain CTD_bind PF04818.13 EEA05896.1 - 3.6e-07 30.9 0.0 1.3e-06 29.1 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. zf-C2H2 PF00096.26 EEA05896.1 - 0.067 13.7 4.1 0.26 11.8 1.0 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type UPF0139 PF03669.13 EEA05897.1 - 0.014 15.2 1.8 0.018 14.9 1.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) DUF92 PF01940.16 EEA05897.1 - 0.061 12.7 0.5 0.073 12.5 0.5 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 APG5 PF04106.12 EEA05898.1 - 5.8e-14 52.2 3.6 3.1e-13 49.8 3.5 1.9 1 1 0 1 1 1 1 Autophagy protein Apg5 Histone PF00125.24 EEA05899.1 - 4.7e-35 120.8 0.0 5.3e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA05899.1 - 0.003 17.8 0.0 0.0083 16.4 0.0 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EEA05899.1 - 0.05 13.7 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold VID27 PF08553.10 EEA05900.1 - 2.2e-58 198.1 0.4 2.2e-58 198.1 0.4 1.6 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain CDC73_C PF05179.14 EEA05901.1 - 3e-38 131.0 1.8 3.9e-38 130.6 0.5 1.8 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal ATP-synt_C PF00137.21 EEA05902.1 - 1.8e-06 28.2 12.2 3.2e-06 27.4 12.2 1.4 1 0 0 1 1 1 1 ATP synthase subunit C ISP1_C PF18161.1 EEA05903.1 - 1.4e-39 134.4 0.0 3.8e-39 133.0 0.0 1.9 1 0 0 1 1 1 1 ISP1 C-terminal ISP3_C PF18045.1 EEA05903.1 - 7.8e-24 83.7 0.0 2e-23 82.4 0.0 1.7 1 0 0 1 1 1 1 ISP3 C-terminal Nop52 PF05997.12 EEA05904.1 - 9.8e-46 156.2 7.4 9.8e-46 156.2 7.4 1.6 2 0 0 2 2 2 1 Nucleolar protein,Nop52 RabGAP-TBC PF00566.18 EEA05905.1 - 1.1e-57 195.2 1.0 2e-57 194.3 1.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TMEM154 PF15102.6 EEA05906.1 - 2.9e-06 27.3 0.1 5.2e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 EEA05906.1 - 0.00093 19.2 0.0 0.0012 18.9 0.0 1.1 1 0 0 1 1 1 1 Rifin DUF2207 PF09972.9 EEA05906.1 - 0.0043 15.9 0.0 0.013 14.3 0.0 1.6 1 1 0 2 2 2 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 EEA05906.1 - 0.0045 17.3 0.1 0.007 16.6 0.1 1.3 1 0 0 1 1 1 1 Orf78 (ac78) TNFR_16_TM PF18422.1 EEA05906.1 - 0.0061 16.5 0.3 0.014 15.4 0.3 1.6 1 0 0 1 1 1 1 Tumor necrosis factor receptor member 16 trans-membrane domain BatD PF13584.6 EEA05906.1 - 0.017 14.0 0.0 0.022 13.6 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF3827 PF12877.7 EEA05906.1 - 0.024 13.0 0.0 0.032 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) EphA2_TM PF14575.6 EEA05906.1 - 0.028 15.3 0.0 0.059 14.3 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.12 EEA05906.1 - 0.04 13.5 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4448 PF14610.6 EEA05906.1 - 0.042 13.6 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF5305 PF17231.2 EEA05906.1 - 0.052 13.0 0.2 0.083 12.3 0.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5305) SUIM_assoc PF16619.5 EEA05906.1 - 0.064 13.3 2.0 0.24 11.5 2.0 2.1 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF5367 PF17329.2 EEA05906.1 - 0.091 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5367) DUF2951 PF11166.8 EEA05906.1 - 0.14 12.4 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) MASE1 PF05231.14 EEA05906.1 - 0.14 11.3 0.1 0.21 10.7 0.1 1.2 1 0 0 1 1 1 0 MASE1 EGL-1 PF11430.8 EEA05906.1 - 0.22 11.4 2.4 0.41 10.5 2.4 1.4 1 0 0 1 1 1 0 Programmed cell death activator EGL-1 ThiF PF00899.21 EEA05907.1 - 4.2e-45 154.0 0.2 5.9e-45 153.5 0.2 1.1 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EEA05907.1 - 0.0064 16.7 1.6 0.14 12.4 1.6 2.4 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EEA05907.1 - 0.021 15.2 0.0 0.06 13.8 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 EEA05907.1 - 0.83 9.9 3.1 5.3 7.3 0.2 3.1 2 1 1 3 3 3 0 TrkA-N domain RNase_PH PF01138.21 EEA05908.1 - 3.5e-16 59.9 0.1 1.2e-15 58.2 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 NDK PF00334.19 EEA05909.1 - 1.8e-52 176.9 0.0 2e-52 176.8 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase ORC2 PF04084.14 EEA05910.1 - 2.7e-50 171.2 4.8 3.7e-50 170.7 4.8 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Pkinase PF00069.25 EEA05911.1 - 3.3e-65 220.1 0.0 6.4e-65 219.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA05911.1 - 3.9e-33 114.8 0.0 6.2e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA05911.1 - 0.00072 18.4 0.0 0.0027 16.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EEA05911.1 - 0.021 14.2 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EEA05911.1 - 0.031 13.6 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EEA05911.1 - 0.059 13.0 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 RIO1 family GCP_N_terminal PF17681.1 EEA05912.1 - 1.8e-35 123.1 8.0 1.1e-34 120.5 4.8 2.8 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EEA05912.1 - 3.3e-25 89.2 4.5 5.3e-25 88.5 1.6 2.5 2 1 0 3 3 3 1 Gamma tubulin complex component C-terminal DUF2683 PF10884.8 EEA05912.1 - 0.088 13.1 2.2 6.7 7.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2683) Hexapep PF00132.24 EEA05913.1 - 1.2e-18 66.0 17.1 2.1e-06 27.2 1.4 4.3 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EEA05913.1 - 0.00029 19.9 5.3 0.00093 18.2 5.3 1.9 1 1 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 EEA05913.1 - 0.00061 18.0 3.0 0.00061 18.0 3.0 1.9 1 1 1 2 2 2 2 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EEA05913.1 - 8.3 6.3 17.9 1.1e+02 2.7 9.2 4.7 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase RRM_1 PF00076.22 EEA05914.1 - 4.3e-18 64.9 0.6 3e-09 36.6 0.3 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EEA05914.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif Nup35_RRM_2 PF14605.6 EEA05914.1 - 0.035 14.1 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif QRPTase_C PF01729.19 EEA05914.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain RRM_occluded PF16842.5 EEA05914.1 - 0.095 12.6 0.0 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EEA05914.1 - 0.36 11.0 5.4 0.54 10.5 0.1 2.8 2 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Mei5 PF10376.9 EEA05915.1 - 0.16 11.8 5.1 3.1 7.6 0.3 2.2 2 0 0 2 2 2 0 Double-strand recombination repair protein DUF4656 PF15551.6 EEA05915.1 - 1.1 8.8 4.3 0.69 9.4 1.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4656) Ebp2 PF05890.12 EEA05916.1 - 2.3e-37 129.0 18.6 2.6e-37 128.8 18.6 1.1 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 DUF1573 PF07610.11 EEA05918.1 - 0.91 9.6 5.1 2.2 8.4 0.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1573) RRM_1 PF00076.22 EEA05920.1 - 2e-15 56.4 0.0 5.1e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA05920.1 - 0.0085 16.2 0.1 0.029 14.5 0.0 2.0 2 1 0 2 2 2 1 RNA recognition motif Stk19 PF10494.9 EEA05921.1 - 7.4e-13 48.8 0.1 2.3e-12 47.1 0.1 1.8 1 1 0 1 1 1 1 Serine-threonine protein kinase 19 DUF1493 PF07377.12 EEA05921.1 - 0.058 13.9 0.2 0.2 12.2 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1493) MAGE PF01454.19 EEA05921.1 - 0.13 11.9 0.1 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 MAGE family ERK-JNK_inhib PF15002.6 EEA05923.1 - 0.67 9.6 3.5 0.98 9.1 0.1 2.8 3 1 1 4 4 4 0 ERK and JNK pathways, inhibitor ANAPC4_WD40 PF12894.7 EEA05924.1 - 0.013 15.8 0.0 38 4.7 0.0 4.1 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Rb_C PF08934.10 EEA05924.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Rb C-terminal domain RNase_PH PF01138.21 EEA05925.1 - 2.6e-28 99.2 0.1 4.6e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF4796 PF16044.5 EEA05925.1 - 0.057 13.0 0.7 0.23 11.0 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4796) Peptidase_M22 PF00814.25 EEA05926.1 - 9.7e-79 264.9 0.0 1.2e-78 264.5 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family DUF5618 PF18498.1 EEA05926.1 - 0.069 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5618) Fn3_assoc PF13287.6 EEA05927.1 - 0.076 13.2 0.1 0.25 11.5 0.1 1.9 2 0 0 2 2 2 0 Fn3 associated Myotub-related PF06602.14 EEA05928.1 - 2.3e-112 375.4 3.4 3.7e-112 374.7 3.4 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 EEA05928.1 - 0.036 13.6 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.20 EEA05928.1 - 0.045 13.6 0.0 0.17 11.7 0.0 2.0 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EEA05928.1 - 0.05 13.6 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DER1 PF04511.15 EEA05929.1 - 4.1e-34 118.2 7.6 5.9e-34 117.7 7.6 1.2 1 0 0 1 1 1 1 Der1-like family RPN6_N PF18055.1 EEA05930.1 - 4e-36 123.9 0.4 1.3e-35 122.3 0.4 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EEA05930.1 - 4.6e-16 59.2 4.0 4.6e-16 59.2 4.0 2.4 2 1 1 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 EEA05930.1 - 4.5e-05 23.1 1.3 5.5e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EEA05930.1 - 0.0012 19.1 2.2 1.9 8.8 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF410 PF04190.13 EEA05930.1 - 0.0034 17.2 0.2 0.13 12.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF410) E3_UFM1_ligase PF09743.9 EEA05930.1 - 0.012 15.3 1.2 0.012 15.3 1.2 1.7 2 0 0 2 2 2 0 E3 UFM1-protein ligase 1 CSN8_PSD8_EIF3K PF10075.9 EEA05930.1 - 0.034 14.1 0.3 0.088 12.8 0.3 1.8 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family Glypican PF01153.19 EEA05930.1 - 0.038 12.8 0.1 0.07 12.0 0.1 1.3 1 0 0 1 1 1 0 Glypican NAD_binding_6 PF08030.12 EEA05930.1 - 0.056 13.6 0.3 0.16 12.1 0.2 1.8 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Aminotran_1_2 PF00155.21 EEA05932.1 - 5.4e-42 144.3 0.0 7.9e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EEA05932.1 - 1.9e-05 23.4 0.0 2.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EEA05932.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.19 EEA05932.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EEA05932.1 - 0.19 11.0 0.1 0.96 8.7 0.1 2.0 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family WD40 PF00400.32 EEA05933.1 - 3e-29 100.6 26.9 4.4e-06 27.3 0.3 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA05933.1 - 4e-12 46.3 0.1 0.34 11.2 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA05933.1 - 9.3e-10 38.0 0.3 0.007 15.4 0.0 3.4 3 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EEA05933.1 - 5.7e-06 25.9 0.2 0.079 12.3 0.0 3.2 2 1 1 3 3 3 2 WD40-like domain eIF2A PF08662.11 EEA05933.1 - 0.00023 21.1 0.4 12 5.8 0.0 4.4 2 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 EEA05933.1 - 0.019 14.5 0.0 0.038 13.6 0.0 1.6 1 1 0 1 1 1 0 PQQ-like domain PQQ_3 PF13570.6 EEA05933.1 - 0.068 13.7 3.3 0.12 12.9 0.6 2.9 3 0 0 3 3 3 0 PQQ-like domain SF-assemblin PF06705.11 EEA05934.1 - 1.9e-36 125.7 32.8 2.5e-36 125.3 32.8 1.2 1 0 0 1 1 1 1 SF-assemblin/beta giardin RRXRR PF14239.6 EEA05934.1 - 0.0031 17.4 0.1 0.0056 16.5 0.1 1.5 1 0 0 1 1 1 1 RRXRR protein ApoO PF09769.9 EEA05934.1 - 1.7 8.6 11.1 3.1 7.8 1.6 3.0 2 1 1 3 3 3 0 Apolipoprotein O Exonuc_VII_L PF02601.15 EEA05934.1 - 5.1 6.6 28.7 2.3 7.7 16.3 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit Dimerisation2 PF16864.5 EEA05935.1 - 0.0079 16.1 0.0 1.9 8.5 0.0 3.0 2 1 1 3 3 3 2 Dimerisation domain Vps39_2 PF10367.9 EEA05935.1 - 0.02 15.3 0.2 1.4 9.4 0.1 2.7 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF1500 PF07389.12 EEA05935.1 - 0.13 12.4 1.1 0.21 11.7 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1500) Ank_2 PF12796.7 EEA05936.1 - 2.3e-05 24.9 0.0 5.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA05936.1 - 4.5e-05 23.5 0.0 0.04 14.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EEA05936.1 - 0.0039 17.5 0.0 0.26 11.6 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA05936.1 - 0.015 15.7 0.0 0.46 11.0 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 EEA05936.1 - 0.08 13.5 0.0 1.3 9.7 0.0 2.6 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Thioredoxin PF00085.20 EEA05937.1 - 3.5e-41 139.4 0.0 3.4e-19 68.7 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 EEA05937.1 - 5.4e-11 42.9 0.1 0.00035 21.0 0.1 3.3 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA05937.1 - 3.8e-06 26.5 0.0 0.015 14.6 0.0 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EEA05937.1 - 4.5e-06 26.9 0.1 2.6 8.4 0.0 4.9 3 2 2 5 5 5 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EEA05937.1 - 4.9e-06 26.6 0.6 0.086 13.0 0.1 3.3 3 2 0 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.6 EEA05937.1 - 0.00046 20.0 0.8 0.67 9.7 0.0 3.4 4 0 0 4 4 4 2 Thioredoxin TraF PF13728.6 EEA05937.1 - 0.0012 18.7 0.0 0.33 10.7 0.0 2.5 2 1 0 2 2 2 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 EEA05937.1 - 0.0092 15.9 0.0 3 7.8 0.0 2.9 3 0 0 3 3 3 1 AhpC/TSA family HyaE PF07449.11 EEA05937.1 - 0.033 14.2 0.0 0.14 12.2 0.0 2.1 1 1 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 EEA05937.1 - 0.062 13.5 0.1 19 5.6 0.0 3.1 3 0 0 3 3 3 0 Glutaredoxin Thioredoxin_5 PF13743.6 EEA05937.1 - 0.21 11.3 2.0 14 5.4 0.2 3.3 3 1 0 4 4 4 0 Thioredoxin Inhibitor_G39P PF11417.8 EEA05937.1 - 0.33 11.5 2.0 2.4 8.7 0.1 3.2 4 0 0 4 4 3 0 Loader and inhibitor of phage G40P Ank_2 PF12796.7 EEA05938.1 - 3.3e-20 72.5 3.0 8.1e-11 42.4 0.2 4.8 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA05938.1 - 1.1e-11 45.0 1.7 1.1e-05 25.9 0.1 5.6 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA05938.1 - 3.3e-10 39.9 8.8 0.026 15.0 0.1 6.5 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EEA05938.1 - 2.8e-09 36.5 5.6 0.023 15.2 0.0 6.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EEA05938.1 - 6.5e-08 32.7 0.8 0.0024 18.1 0.0 4.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) F-box PF00646.33 EEA05939.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 F-box domain WGG PF10273.9 EEA05940.1 - 8.8e-19 68.0 0.1 1.5e-18 67.2 0.1 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 Seryl_tRNA_N PF02403.22 EEA05942.1 - 0.75 10.1 36.6 0.088 13.0 0.9 5.8 2 2 3 5 5 5 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.12 EEA05942.1 - 1.9 9.0 21.9 0.42 11.1 0.1 5.8 3 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EEA05942.1 - 5.5 7.0 31.2 5.2 7.1 4.3 4.9 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) PUB PF09409.10 EEA05943.1 - 4.2e-11 42.6 0.0 1.1e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 PUB domain TPR_7 PF13176.6 EEA05943.1 - 0.033 14.2 0.0 0.23 11.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TRCF PF03461.15 EEA05943.1 - 0.13 12.7 0.5 19 5.7 0.0 3.5 4 0 0 4 4 4 0 TRCF domain TPR_19 PF14559.6 EEA05943.1 - 0.14 12.7 0.0 0.45 11.1 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_S30 PF04758.14 EEA05944.1 - 1.6e-26 92.3 11.7 1.7e-26 92.2 11.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 P5CR_dimer PF14748.6 EEA05945.1 - 2.5e-21 75.8 0.0 3.9e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EEA05945.1 - 6.9e-17 61.8 0.1 1.4e-16 60.9 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EEA05945.1 - 0.02 15.1 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EEA05945.1 - 0.023 14.0 0.0 0.058 12.8 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 EEA05945.1 - 0.04 12.9 0.1 0.29 10.0 0.0 2.0 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family PDH PF02153.17 EEA05945.1 - 0.047 12.7 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase AHJR-like PF18743.1 EEA05947.1 - 0.0056 16.2 1.1 0.019 14.5 0.3 2.1 2 0 0 2 2 2 1 REase_AHJR-like DUF1829 PF08862.10 EEA05947.1 - 2.1 8.9 5.7 28 5.3 0.0 3.8 3 1 1 4 4 4 0 Domain of unknown function DUF1829 TRAPP PF04051.16 EEA05948.1 - 3.8e-37 127.2 0.0 4.5e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Alpha-amylase PF00128.24 EEA05949.1 - 7.8e-19 68.4 0.0 8.5e-10 38.7 0.1 2.5 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 EEA05949.1 - 4.6e-06 26.9 0.1 1.1e-05 25.7 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 EEA05949.1 - 0.002 18.5 0.2 0.016 15.7 0.1 2.4 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain GYF PF02213.16 EEA05950.1 - 2.9e-10 39.7 0.5 6.2e-10 38.6 0.5 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EEA05950.1 - 0.039 13.8 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 GYF domain 2 DICT PF10069.9 EEA05950.1 - 0.083 12.7 1.0 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 Sensory domain in DIguanylate Cyclases and Two-component system Gp_dh_C PF02800.20 EEA05953.1 - 3.3e-64 215.2 0.0 4.4e-64 214.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EEA05953.1 - 1.9e-39 134.1 0.0 4e-39 133.0 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EEA05953.1 - 0.02 14.2 0.0 0.04 13.3 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Hexokinase_2 PF03727.16 EEA05954.1 - 3.3e-55 187.1 0.1 5.2e-55 186.5 0.1 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EEA05954.1 - 4.4e-44 150.8 0.0 7.5e-43 146.8 0.0 2.6 2 1 0 2 2 2 1 Hexokinase NUDIX_2 PF13869.6 EEA05955.1 - 1.3e-61 207.4 0.0 1.6e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase Asp PF00026.23 EEA05956.1 - 4.4e-73 246.4 0.0 9.1e-73 245.4 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA05956.1 - 3.3e-17 63.3 0.0 7.2e-10 39.4 0.0 3.1 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EEA05956.1 - 0.00083 19.9 0.0 1.4 9.6 0.0 3.1 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EEA05956.1 - 0.0087 16.6 0.0 6.6 7.4 0.0 3.0 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Ras PF00071.22 EEA05957.1 - 1.1e-59 200.6 0.3 1.4e-59 200.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA05957.1 - 6.7e-37 126.4 0.5 1.1e-35 122.4 0.1 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA05957.1 - 3.7e-13 49.3 0.2 4.4e-13 49.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA05957.1 - 6.7e-06 25.6 0.1 8.8e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EEA05957.1 - 1.1e-05 25.4 0.5 0.087 12.7 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EEA05957.1 - 1.4e-05 25.2 0.0 2.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA05957.1 - 0.00017 21.2 0.2 0.00039 20.0 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EEA05957.1 - 0.0048 17.2 0.0 0.1 12.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.10 EEA05957.1 - 0.018 14.5 0.1 0.028 13.9 0.1 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EEA05957.1 - 0.024 15.0 0.0 0.034 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 EEA05957.1 - 0.099 12.7 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain SET PF00856.28 EEA05958.1 - 0.0046 17.4 0.1 0.013 15.8 0.0 2.0 1 1 1 2 2 2 1 SET domain Ribosomal_L7Ae PF01248.26 EEA05959.1 - 3.8e-24 84.2 0.3 4.8e-24 83.9 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EEA05959.1 - 0.034 14.0 0.1 0.045 13.6 0.1 1.2 1 0 0 1 1 1 0 PELOTA RNA binding domain P22_AR_C PF10548.9 EEA05960.1 - 0.065 13.4 0.4 0.15 12.3 0.4 1.6 1 0 0 1 1 1 0 P22AR C-terminal domain Fib_alpha PF08702.10 EEA05960.1 - 0.088 13.0 1.9 0.16 12.1 0.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 EEA05960.1 - 0.22 12.0 1.7 0.76 10.3 0.1 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CDT1 PF08839.11 EEA05961.1 - 2.1e-33 116.1 0.1 2.1e-33 116.1 0.1 2.2 2 1 0 2 2 2 1 DNA replication factor CDT1 like RNase_HII PF01351.18 EEA05962.1 - 3.1e-53 180.6 0.0 1.2e-52 178.7 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease HII Dpy19 PF10034.9 EEA05964.1 - 1.2e-174 582.2 34.3 1.9e-174 581.5 34.3 1.3 1 0 0 1 1 1 1 Q-cell neuroblast polarisation TPR_17 PF13431.6 EEA05964.1 - 0.012 16.0 2.4 0.029 14.7 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4357 PF14267.6 EEA05964.1 - 0.081 12.9 0.0 0.51 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) TRAM_LAG1_CLN8 PF03798.16 EEA05965.1 - 1.5e-29 103.2 32.4 2.6e-29 102.4 32.4 1.4 1 0 0 1 1 1 1 TLC domain DUF4834 PF16118.5 EEA05965.1 - 0.16 13.0 0.1 0.16 13.0 0.1 2.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) TAXi_N PF14543.6 EEA05966.1 - 3.7e-24 85.9 2.6 5.3e-24 85.4 1.4 1.9 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp PF00026.23 EEA05966.1 - 3.3e-12 46.5 2.5 4.1e-07 29.7 0.1 2.4 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.6 EEA05966.1 - 0.00054 19.8 0.0 0.0019 18.0 0.0 1.9 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal MIT_C PF16565.5 EEA05966.1 - 0.021 14.8 0.5 0.66 9.9 0.1 2.4 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT DUF5461 PF17545.2 EEA05966.1 - 0.055 13.8 2.1 0.18 12.1 0.2 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5461) SMC_N PF02463.19 EEA05967.1 - 9.8e-66 221.3 12.8 1.5e-37 129.1 1.5 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA05967.1 - 6.7e-21 74.8 0.0 1.8e-20 73.4 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EEA05967.1 - 4.8e-08 33.2 22.1 0.00023 21.1 2.1 4.4 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EEA05967.1 - 3.5e-06 27.0 18.9 3.5e-06 27.0 18.9 4.2 1 1 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 EEA05967.1 - 0.00032 20.4 0.0 0.0008 19.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EEA05967.1 - 0.01 16.4 22.4 0.027 15.0 0.0 5.4 4 1 0 4 4 4 0 ABC transporter CitG PF01874.16 EEA05967.1 - 0.088 12.4 0.0 0.29 10.7 0.0 1.9 1 0 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase bPH_2 PF03703.14 EEA05967.1 - 0.16 12.1 0.0 0.54 10.5 0.0 1.9 1 0 0 1 1 1 0 Bacterial PH domain Adaptin_N PF01602.20 EEA05968.1 - 1.2e-70 238.6 17.3 2.1e-70 237.8 17.3 1.4 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.6 EEA05968.1 - 0.00021 21.6 0.0 0.00057 20.2 0.0 1.8 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Cnd1 PF12717.7 EEA05968.1 - 0.005 16.9 12.1 0.0068 16.5 0.1 3.4 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 dsDNA_bind PF01984.20 EEA05969.1 - 2.7e-16 59.8 3.7 3.2e-16 59.6 3.7 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF1073 PF06381.11 EEA05969.1 - 0.0011 17.9 0.1 0.0011 17.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1073) RPEL PF02755.15 EEA05969.1 - 0.0099 15.6 0.7 0.033 13.9 0.1 2.2 2 0 0 2 2 2 1 RPEL repeat DUF4332 PF14229.6 EEA05969.1 - 0.017 15.4 0.2 0.017 15.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) DFP PF04127.15 EEA05972.1 - 7.6e-15 55.2 0.0 8.2e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein DUF2887 PF11103.8 EEA05972.1 - 0.036 14.1 0.5 8.6 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2887) F-box-like PF12937.7 EEA05973.1 - 0.0041 17.0 1.5 0.01 15.7 1.5 1.7 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EEA05973.1 - 0.041 13.5 1.5 0.041 13.5 1.5 1.9 2 0 0 2 2 2 0 F-box PPR_3 PF13812.6 EEA05973.1 - 0.082 13.0 1.1 0.31 11.1 0.1 2.0 2 0 0 2 2 2 0 Pentatricopeptide repeat domain F-box PF00646.33 EEA05973.1 - 0.12 12.2 1.8 0.2 11.6 0.3 2.1 2 0 0 2 2 2 0 F-box domain RL10P_insert PF17777.1 EEA05974.1 - 4.2e-23 81.1 0.3 7.4e-23 80.3 0.3 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EEA05974.1 - 2.9e-18 65.8 0.1 6.4e-18 64.7 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 EEA05974.1 - 4.7e-05 23.9 3.7 0.00024 21.6 3.7 2.2 1 1 0 1 1 1 1 60s Acidic ribosomal protein Lipid_DES PF08557.10 EEA05974.1 - 0.13 11.8 0.2 0.26 10.8 0.2 1.4 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) adh_short PF00106.25 EEA05975.1 - 5e-29 101.1 0.1 6e-24 84.6 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EEA05975.1 - 2.8e-17 63.1 0.0 1.4e-15 57.5 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA05975.1 - 1.7e-08 34.6 0.1 2.5e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA05975.1 - 0.00054 19.5 0.0 0.00076 19.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family zf-met PF12874.7 EEA05975.1 - 0.0026 18.1 0.2 2.2 8.8 0.0 3.0 2 0 0 2 2 2 2 Zinc-finger of C2H2 type GDP_Man_Dehyd PF16363.5 EEA05975.1 - 0.042 13.2 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ISP3_C PF18045.1 EEA05976.1 - 0.0023 17.8 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 ISP3 C-terminal DUF1647 PF07801.11 EEA05976.1 - 0.0085 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) AD PF09793.9 EEA05977.1 - 1e-16 60.8 0.0 1.8e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain Gemin6 PF06372.12 EEA05977.1 - 0.00087 18.9 0.1 0.03 13.9 0.0 2.1 2 0 0 2 2 2 2 Gemin6 protein ThiF PF00899.21 EEA05978.1 - 2.5e-85 285.7 0.1 2.4e-60 203.9 0.0 2.3 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EEA05978.1 - 9.5e-78 261.6 2.9 1.5e-77 260.9 2.9 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EEA05978.1 - 2.8e-27 94.7 0.1 8.8e-27 93.1 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EEA05978.1 - 1.6e-19 70.4 0.0 4.7e-19 68.9 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EEA05978.1 - 2.7e-16 59.5 0.1 8.7e-16 57.9 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle NOP19 PF10863.8 EEA05978.1 - 0.038 13.8 0.1 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Nucleolar protein 19 PFU PF09070.11 EEA05979.1 - 4.8e-27 94.5 0.5 8.6e-27 93.6 0.5 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EEA05979.1 - 2.9e-25 88.0 21.1 9.6e-07 29.4 0.2 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat PUL PF08324.11 EEA05979.1 - 1.8e-18 66.8 0.1 2.8e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 PUL domain Nup160 PF11715.8 EEA05979.1 - 0.00024 19.9 8.0 0.022 13.4 0.4 3.5 1 1 1 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EEA05979.1 - 0.019 15.0 0.1 2 8.5 0.0 3.3 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DUF2070 PF09843.9 EEA05981.1 - 0.089 11.1 4.7 0.12 10.6 4.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ATP-synt PF00231.19 EEA05982.1 - 6.5e-65 219.6 0.7 7.4e-65 219.4 0.7 1.0 1 0 0 1 1 1 1 ATP synthase ubiquitin PF00240.23 EEA05983.1 - 1.3e-17 63.3 0.1 2.2e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EEA05983.1 - 3e-06 27.0 0.1 7.3e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 EEA05983.1 - 4e-06 26.6 0.0 6.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 EEA05983.1 - 5.2e-05 23.1 9.8 0.0082 16.1 0.7 3.6 2 1 1 3 3 3 1 STI1 domain CUE PF02845.16 EEA05983.1 - 0.0005 19.7 0.1 0.0066 16.1 0.0 2.8 3 0 0 3 3 3 1 CUE domain DUF2407 PF10302.9 EEA05983.1 - 0.0072 16.9 0.1 0.014 16.0 0.1 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA05983.1 - 0.029 14.5 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like E3_UbLigase_EDD PF11547.8 EEA05983.1 - 0.064 13.0 1.1 0.18 11.6 0.0 2.3 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD TBK1_ULD PF18396.1 EEA05983.1 - 0.08 12.9 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain HOIP-UBA PF16678.5 EEA05983.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair GerD PF17898.1 EEA05983.1 - 0.28 11.1 3.1 1.7 8.6 3.1 2.2 1 1 0 1 1 1 0 Spore germination GerD central core domain tRNA-synt_2 PF00152.20 EEA05984.1 - 5.3e-75 252.4 0.0 6.7e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EEA05984.1 - 1.6e-11 44.0 0.0 4.3e-11 42.6 0.1 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EEA05984.1 - 2e-07 30.7 0.0 0.0031 17.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) HEAT PF02985.22 EEA05985.1 - 2.7e-08 33.4 2.4 52 4.5 0.0 8.3 8 0 0 8 8 8 0 HEAT repeat HEAT_2 PF13646.6 EEA05985.1 - 0.00013 22.3 0.0 0.095 13.1 0.0 4.6 3 1 1 4 4 4 1 HEAT repeats Rsbr_N PF08678.10 EEA05985.1 - 0.055 13.5 0.7 0.18 11.8 0.4 2.1 2 0 0 2 2 2 0 Rsbr N terminal DUF1981 PF09324.10 EEA05985.1 - 0.088 12.7 0.7 6.3 6.7 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) IFRD PF05004.13 EEA05985.1 - 0.4 9.8 3.6 9.3 5.3 0.1 2.9 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Mon1 PF03164.14 EEA05986.1 - 3.9e-46 157.9 14.9 1.9e-45 155.7 14.9 1.8 1 1 0 1 1 1 1 Trafficking protein Mon1 RelE PF06296.12 EEA05986.1 - 0.0029 17.7 0.0 0.0054 16.8 0.0 1.5 1 0 0 1 1 1 1 RelE toxin of RelE / RelB toxin-antitoxin system Vps35 PF03635.17 EEA05987.1 - 1.6e-242 807.2 15.5 1.9e-242 807.0 15.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Npa1 PF11707.8 EEA05987.1 - 0.012 15.0 1.5 0.2 11.0 0.0 2.6 2 0 0 2 2 2 0 Ribosome 60S biogenesis N-terminal Ribosomal_L31e PF01198.19 EEA05988.1 - 2.2e-35 120.7 0.3 2.6e-35 120.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Ank_2 PF12796.7 EEA05990.1 - 4.7e-29 100.8 5.3 2e-11 44.3 0.1 4.1 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EEA05990.1 - 1.1e-22 77.6 1.1 0.00011 22.3 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EEA05990.1 - 1.1e-21 76.2 3.8 7.8e-05 22.9 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EEA05990.1 - 1.1e-19 70.5 0.3 4.7e-06 27.0 0.0 5.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA05990.1 - 3.3e-18 65.5 0.0 0.00044 20.5 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Sushi PF00084.20 EEA05990.1 - 2.6e-08 34.3 0.3 1.3e-07 32.1 0.3 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) Cadherin_C_2 PF16492.5 EEA05990.1 - 0.13 13.0 0.5 0.3 11.9 0.5 1.6 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal IncF PF17626.2 EEA05992.1 - 0.17 12.3 2.3 0.33 11.3 0.3 2.2 2 0 0 2 2 2 0 Inclusion membrane protein F TBCC PF07986.12 EEA05994.1 - 5.7e-24 84.2 1.0 1.1e-23 83.2 1.1 1.5 2 0 0 2 2 2 1 Tubulin binding cofactor C Choline_transpo PF04515.12 EEA05996.1 - 0.061 12.5 1.4 0.41 9.8 0.3 2.5 2 1 0 2 2 2 0 Plasma-membrane choline transporter ERGIC_N PF13850.6 EEA05998.1 - 7.3 7.0 9.7 6.9 7.1 0.2 3.0 2 1 1 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ANAPC_CDC26 PF10471.9 EEA05999.1 - 3.9 8.4 5.9 0.59 11.0 0.3 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 DASH_Dad3 PF08656.10 EEA06000.1 - 0.011 15.8 0.1 0.045 13.8 0.1 2.1 1 0 0 1 1 1 0 DASH complex subunit Dad3 Arm_vescicular PF18770.1 EEA06001.1 - 0.082 12.9 1.8 0.17 11.9 1.8 1.4 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor BILBO1_N PF18281.1 EEA06002.1 - 0.011 16.2 0.1 0.036 14.5 0.1 1.8 1 1 1 2 2 2 0 BILBO1 N-terminal domain AAA PF00004.29 EEA06003.1 - 1.4e-44 151.8 0.0 3.9e-44 150.3 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EEA06003.1 - 1.8e-09 37.4 0.1 1.1e-08 34.9 0.0 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EEA06003.1 - 1.1e-08 35.4 0.0 2.9e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA06003.1 - 1.3e-08 35.0 0.1 4.7e-08 33.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EEA06003.1 - 1.9e-08 34.0 0.0 5.1e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EEA06003.1 - 1.9e-06 28.4 0.3 0.00037 20.9 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EEA06003.1 - 2.9e-05 23.3 0.0 7e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EEA06003.1 - 7e-05 23.4 0.0 0.00022 21.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 EEA06003.1 - 9e-05 22.3 0.0 0.00027 20.7 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA06003.1 - 0.00012 22.3 3.3 0.007 16.6 0.1 2.8 2 1 1 3 3 2 1 AAA domain NTPase_1 PF03266.15 EEA06003.1 - 0.00023 21.1 0.1 0.017 15.1 0.0 2.8 3 0 0 3 3 3 1 NTPase AAA_28 PF13521.6 EEA06003.1 - 0.00025 21.3 0.0 0.00056 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EEA06003.1 - 0.00074 19.9 0.0 0.0018 18.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 EEA06003.1 - 0.00095 18.9 0.0 0.004 16.9 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 EEA06003.1 - 0.0014 18.4 0.1 0.043 13.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EEA06003.1 - 0.0015 18.7 0.0 0.0051 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EEA06003.1 - 0.0015 17.9 0.1 0.0037 16.7 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EEA06003.1 - 0.003 16.8 0.0 0.013 14.7 0.0 1.9 2 1 0 2 2 2 1 TIP49 P-loop domain TsaE PF02367.17 EEA06003.1 - 0.0051 16.8 0.0 0.0094 16.0 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EEA06003.1 - 0.0057 16.2 0.1 0.036 13.6 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 EEA06003.1 - 0.0076 16.3 0.2 0.034 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EEA06003.1 - 0.008 15.9 0.2 0.018 14.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EEA06003.1 - 0.0087 15.8 0.3 0.11 12.2 0.0 2.3 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 EEA06003.1 - 0.0095 15.5 1.5 0.071 12.7 0.2 2.3 1 1 0 2 2 2 1 AAA domain DUF3450 PF11932.8 EEA06003.1 - 0.011 15.0 1.3 0.024 13.9 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) AAA_30 PF13604.6 EEA06003.1 - 0.016 14.9 0.4 0.041 13.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EEA06003.1 - 0.02 14.3 0.0 1.6 8.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein Parvo_NS1 PF01057.17 EEA06003.1 - 0.023 13.8 0.0 0.05 12.7 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 EEA06003.1 - 0.03 14.3 0.2 0.16 11.9 0.1 2.1 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 EEA06003.1 - 0.031 14.2 0.1 0.49 10.3 0.1 2.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EEA06003.1 - 0.034 13.9 0.3 0.37 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EEA06003.1 - 0.046 14.1 0.1 0.55 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain GrpE PF01025.19 EEA06003.1 - 0.049 13.3 1.2 0.25 11.0 0.3 2.1 2 0 0 2 2 2 0 GrpE ATPase PF06745.13 EEA06003.1 - 0.055 12.8 1.8 0.89 8.9 0.0 2.7 3 0 0 3 3 3 0 KaiC NB-ARC PF00931.22 EEA06003.1 - 0.057 12.6 0.1 0.25 10.5 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain DUF3363 PF11843.8 EEA06003.1 - 0.062 12.2 0.0 0.095 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3363) KAP_NTPase PF07693.14 EEA06003.1 - 0.062 12.5 0.1 18 4.4 0.0 3.0 2 1 0 3 3 3 0 KAP family P-loop domain ADIP PF11559.8 EEA06003.1 - 0.12 12.4 5.1 0.24 11.5 5.1 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Sigma54_activ_2 PF14532.6 EEA06003.1 - 0.18 11.9 0.9 0.79 9.8 0.0 2.4 2 2 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EEA06003.1 - 0.22 12.0 1.5 0.62 10.6 0.1 2.6 2 2 0 2 2 2 0 ABC transporter HIP1_clath_bdg PF16515.5 EEA06003.1 - 0.5 11.0 4.2 1.9 9.2 2.7 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 polyprenyl_synt PF00348.17 EEA06004.1 - 5.7e-55 186.1 0.0 7.5e-55 185.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase UQ_con PF00179.26 EEA06006.1 - 2.4e-15 56.4 0.0 3.3e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA06006.1 - 0.044 14.1 0.0 0.074 13.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF2518 PF10726.9 EEA06007.1 - 0.22 11.2 3.0 0.45 10.2 3.0 1.5 1 0 0 1 1 1 0 Protein of function (DUF2518) YrhC PF14143.6 EEA06007.1 - 0.76 9.9 3.9 0.5 10.5 0.3 2.3 1 1 2 3 3 3 0 YrhC-like protein PI-PLC-X PF00388.19 EEA06008.1 - 1.5e-59 199.8 0.0 2.7e-59 198.9 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EEA06008.1 - 6.6e-30 103.8 0.0 1.5e-29 102.6 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_1 PF00036.32 EEA06008.1 - 4.7e-10 38.3 0.1 0.002 17.5 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EEA06008.1 - 1.4e-07 31.9 3.8 7e-06 26.4 0.4 3.1 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 EEA06008.1 - 5.5e-06 26.1 0.2 7.2e-05 22.6 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA06008.1 - 2.7e-05 23.8 7.9 0.04 13.8 0.1 4.4 5 0 0 5 5 5 2 EF-hand domain Mcp5_PH PF12814.7 EEA06008.1 - 5.9e-05 23.2 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_12 PF16457.5 EEA06008.1 - 8.8e-05 23.0 0.0 0.00022 21.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_10 PF14788.6 EEA06008.1 - 0.00029 20.7 0.1 0.00061 19.6 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_4 PF12763.7 EEA06008.1 - 0.0014 18.5 0.2 0.021 14.8 0.0 2.8 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EEA06008.1 - 0.062 12.8 0.3 2.7 7.7 0.1 3.1 2 0 0 2 2 2 0 EF hand WD40 PF00400.32 EEA06009.1 - 0.00014 22.6 3.2 4.6 8.3 0.0 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EEA06009.1 - 0.004 17.6 1.1 1.4 9.6 0.1 3.7 4 0 0 4 4 4 1 PQQ-like domain TIR_3 PF18567.1 EEA06009.1 - 0.14 12.2 0.2 0.43 10.6 0.2 1.8 1 0 0 1 1 1 0 Toll/interleukin-1 receptor domain Oxysterol_BP PF01237.18 EEA06010.1 - 1.3e-120 402.7 0.3 4.4e-120 400.9 0.3 1.9 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 EEA06010.1 - 1.2e-05 25.8 1.1 2.7e-05 24.6 1.1 1.7 1 0 0 1 1 1 1 PH domain GDPD PF03009.17 EEA06011.1 - 6.6e-39 134.2 0.0 1.2e-38 133.3 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 EEA06011.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain GDP_Man_Dehyd PF16363.5 EEA06012.1 - 2.9e-51 174.8 0.0 3.4e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA06012.1 - 6.3e-47 160.1 0.0 8e-47 159.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EEA06012.1 - 3.8e-14 52.5 0.0 1.6e-13 50.5 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EEA06012.1 - 1.6e-12 47.0 0.0 6.1e-12 45.1 0.0 1.9 3 0 0 3 3 3 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EEA06012.1 - 3.3e-10 39.5 0.0 6.4e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EEA06012.1 - 2.5e-05 23.6 0.0 0.00034 19.9 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein KR PF08659.10 EEA06012.1 - 0.00014 21.8 0.0 0.00028 20.8 0.0 1.4 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EEA06012.1 - 0.00023 20.7 0.0 0.00033 20.2 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EEA06012.1 - 0.00061 19.7 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding SAS-6_N PF16531.5 EEA06013.1 - 7.5e-20 71.3 1.6 7.5e-20 71.3 1.6 1.7 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal Nop53 PF07767.11 EEA06015.1 - 1.7e-09 37.6 21.8 2.6e-08 33.7 21.8 2.0 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) TBCC_N PF16752.5 EEA06016.1 - 0.056 13.9 1.1 5.2 7.5 0.3 2.8 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain PDCD2_C PF04194.13 EEA06017.1 - 1.1e-32 113.5 3.9 4.3e-32 111.6 1.1 2.1 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain PI3_PI4_kinase PF00454.27 EEA06018.1 - 1.7e-45 155.8 0.0 7.1e-45 153.8 0.0 2.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EEA06018.1 - 7.1e-08 32.1 2.7 8.3e-08 31.9 0.0 2.7 3 0 0 3 3 3 1 FATC domain FAT PF02259.23 EEA06018.1 - 0.035 13.3 0.6 0.19 10.9 0.1 2.1 2 0 0 2 2 2 0 FAT domain UME PF08064.13 EEA06018.1 - 0.046 13.6 0.3 1 9.3 0.1 3.4 2 0 0 2 2 2 0 UME (NUC010) domain Bax1-I PF01027.20 EEA06019.1 - 8.2e-34 117.2 39.2 9.8e-34 117.0 39.2 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2721 PF11026.8 EEA06019.1 - 0.00047 20.0 1.2 0.00047 20.0 1.2 3.3 1 1 0 3 3 3 1 Protein of unknown function (DUF2721) Sec7 PF01369.20 EEA06020.1 - 7.6e-64 214.8 1.7 7.6e-64 214.8 1.7 2.7 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EEA06020.1 - 2.7e-20 72.9 2.6 2.7e-20 72.9 2.6 4.1 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal UTP15_C PF09384.10 EEA06020.1 - 0.05 13.3 0.0 0.18 11.5 0.0 2.0 1 0 0 1 1 1 0 UTP15 C terminal Flavodoxin_1 PF00258.25 EEA06021.1 - 1.9e-20 73.5 0.0 3.7e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EEA06021.1 - 7.5e-19 68.2 0.2 1.3e-18 67.4 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EEA06021.1 - 6.3e-12 46.1 0.0 1.7e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EEA06021.1 - 0.086 13.1 0.0 0.39 10.9 0.0 2.0 2 0 0 2 2 2 0 Flavodoxin domain SGIII PF15467.6 EEA06021.1 - 0.16 11.2 0.1 0.88 8.8 0.0 1.9 2 0 0 2 2 2 0 Secretogranin-3 LSM PF01423.22 EEA06022.1 - 4.4e-19 67.9 0.6 6.4e-19 67.4 0.6 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA06022.1 - 0.0052 16.9 0.1 0.0068 16.5 0.1 1.3 1 1 0 1 1 1 1 Ataxin 2 SM domain E1-E2_ATPase PF00122.20 EEA06023.1 - 3.8e-49 166.6 3.8 6.1e-48 162.7 0.0 2.8 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EEA06023.1 - 6.4e-35 120.5 1.8 6.4e-35 120.5 1.8 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EEA06023.1 - 3.4e-21 76.5 1.1 1.4e-15 58.1 0.4 3.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA06023.1 - 5.9e-18 64.3 0.4 1.5e-17 63.0 0.4 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EEA06023.1 - 2.9e-10 40.1 1.3 6.2e-09 35.8 0.3 3.4 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA06023.1 - 0.0019 18.0 0.5 0.0019 18.0 0.5 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA06023.1 - 0.0059 17.0 0.1 0.044 14.2 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2190 PF09956.9 EEA06023.1 - 0.025 15.0 1.6 0.089 13.3 1.6 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2190) LMBR1 PF04791.16 EEA06023.1 - 0.54 9.1 5.5 0.49 9.3 0.5 2.6 2 1 1 3 3 3 0 LMBR1-like membrane protein DUF4064 PF13273.6 EEA06023.1 - 0.77 10.1 14.7 0.5 10.7 0.3 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) Peptidase_M20 PF01546.28 EEA06024.1 - 3.2e-23 82.5 0.0 4e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EEA06024.1 - 5.5e-11 42.3 0.0 1.4e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Brix PF04427.18 EEA06026.1 - 4.7e-33 114.9 0.2 6.7e-33 114.4 0.2 1.2 1 0 0 1 1 1 1 Brix domain WD40 PF00400.32 EEA06027.1 - 1.5e-10 41.5 7.0 5.7e-05 23.8 0.1 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06027.1 - 0.0043 17.3 0.5 0.067 13.5 0.2 3.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA06027.1 - 0.0082 14.8 1.0 0.94 8.0 0.0 3.2 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EEA06027.1 - 0.022 13.5 0.3 43 2.7 0.0 3.9 2 1 2 4 4 4 0 Nup133 N terminal like Mg_trans_NIPA PF05653.14 EEA06028.1 - 3e-26 92.2 21.2 1.8e-16 60.1 5.2 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EEA06028.1 - 1.1e-05 25.6 3.8 1.1e-05 25.6 3.8 3.0 3 1 0 3 3 3 1 EamA-like transporter family MOZART1 PF12554.8 EEA06029.1 - 5.7e-18 64.4 2.0 6.8e-18 64.2 2.0 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Aa_trans PF01490.18 EEA06030.1 - 3.9e-28 98.3 31.3 1.1e-27 96.8 31.3 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2085 PF09858.9 EEA06030.1 - 0.071 13.6 0.0 0.071 13.6 0.0 3.6 4 1 0 4 4 4 0 Predicted membrane protein (DUF2085) DnaJ_C PF01556.18 EEA06031.1 - 3.3e-36 124.6 0.0 4.3e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA06031.1 - 6.1e-27 93.5 0.5 9.9e-27 92.9 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA06031.1 - 0.31 11.4 2.0 0.63 10.4 2.0 1.5 1 0 0 1 1 1 0 DnaJ central domain CDP-OH_P_transf PF01066.21 EEA06032.1 - 4.8e-16 59.3 0.6 4.8e-16 59.3 0.6 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DnaJ PF00226.31 EEA06033.1 - 3.5e-20 71.9 0.9 6.9e-20 70.9 0.9 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1878 PF08963.10 EEA06033.1 - 0.013 16.0 2.4 0.16 12.4 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1878) Peptidase_C71 PF12386.8 EEA06033.1 - 0.036 13.7 0.9 0.068 12.8 0.9 1.5 1 0 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei DUF5341 PF17276.2 EEA06033.1 - 0.074 13.2 6.1 0.095 12.9 5.4 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5341) APC_N_CC PF16689.5 EEA06033.1 - 0.11 12.6 3.7 0.25 11.4 3.7 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain zf-LITAF-like PF10601.9 EEA06034.1 - 2.2e-15 56.7 7.2 2.2e-15 56.7 7.2 2.3 1 1 1 2 2 2 1 LITAF-like zinc ribbon domain BSMAP PF12280.8 EEA06034.1 - 0.078 13.2 0.3 1.3 9.2 0.1 2.1 2 0 0 2 2 2 0 Brain specific membrane anchored protein Rubredoxin PF00301.20 EEA06034.1 - 0.35 10.9 2.8 0.41 10.7 0.3 2.3 2 0 0 2 2 2 0 Rubredoxin HemY_N PF07219.13 EEA06034.1 - 2.3 8.5 3.3 8.1 6.7 0.3 2.2 2 0 0 2 2 2 0 HemY protein N-terminus HypA PF01155.19 EEA06034.1 - 3.5 7.7 7.5 21 5.2 7.5 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2541 PF10807.8 EEA06036.1 - 0.17 12.0 4.1 0.087 12.9 1.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2541) Tom22 PF04281.13 EEA06037.1 - 2.3e-06 27.4 0.0 2.4e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Phenol_monoox PF04663.12 EEA06037.1 - 0.098 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Phenol hydroxylase conserved region EMG1 PF03587.14 EEA06038.1 - 2.9e-46 157.6 0.2 3.4e-46 157.4 0.2 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase EMG1 PF03587.14 EEA06039.1 - 4e-62 209.3 0.4 4.9e-62 209.0 0.4 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase DnaJ PF00226.31 EEA06040.1 - 0.046 13.8 1.0 0.16 12.2 0.0 2.5 2 0 0 2 2 2 0 DnaJ domain Tubulin PF00091.25 EEA06043.1 - 1.4e-67 227.7 0.0 2.1e-67 227.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA06043.1 - 8.8e-51 171.3 0.3 2.1e-50 170.1 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EEA06043.1 - 0.028 14.1 0.0 0.063 12.9 0.0 1.7 1 0 0 1 1 1 0 Tubulin domain Sugar_tr PF00083.24 EEA06044.1 - 9.6e-25 87.3 35.9 3.8e-14 52.4 13.2 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EEA06044.1 - 1.6e-06 27.3 46.7 1.8e-06 27.2 18.5 3.0 2 2 0 2 2 2 2 Major Facilitator Superfamily MCLC PF05934.11 EEA06044.1 - 8.6 5.0 5.4 4.7 5.8 3.4 1.5 2 0 0 2 2 2 0 Mid-1-related chloride channel (MCLC) HCMV_UL139 PF12507.8 EEA06045.1 - 0.07 13.5 3.8 0.082 13.3 1.4 2.3 2 1 0 2 2 2 0 Human Cytomegalovirus UL139 protein TolA_bind_tri PF16331.5 EEA06045.1 - 0.87 9.7 11.0 0.32 11.1 6.4 2.6 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF2408 PF10303.9 EEA06045.1 - 2.8 8.5 22.8 4.2 7.9 17.0 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF2935 PF11155.8 EEA06045.1 - 5.4 7.4 10.7 0.88 9.9 2.1 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF2935) Ac110_PIF PF07280.11 EEA06046.1 - 0.65 9.8 10.3 0.91 9.4 0.1 4.1 3 0 0 3 3 3 0 Per os infectivity factor AC110 ketoacyl-synt PF00109.26 EEA06047.1 - 0 1546.8 0.0 1.5e-73 247.5 0.0 7.7 8 0 0 8 8 8 7 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EEA06047.1 - 1e-242 790.0 8.9 2.5e-37 127.5 0.0 7.7 7 0 0 7 7 7 7 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EEA06047.1 - 3e-201 662.6 0.0 3.7e-50 170.3 0.0 6.2 6 0 0 6 6 6 5 KR domain PP-binding PF00550.25 EEA06047.1 - 2.2e-94 309.8 17.2 4e-13 49.5 0.2 9.2 8 0 0 8 8 8 8 Phosphopantetheine attachment site Acyl_transf_1 PF00698.21 EEA06047.1 - 1.1e-91 307.6 0.0 1.7e-46 159.2 0.0 3.3 3 0 0 3 3 3 3 Acyl transferase domain PS-DH PF14765.6 EEA06047.1 - 9e-87 291.1 0.0 7.3e-33 114.1 0.0 4.6 4 1 0 4 4 4 4 Polyketide synthase dehydratase AMP-binding PF00501.28 EEA06047.1 - 2.3e-61 207.7 0.0 8.2e-61 205.9 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EEA06047.1 - 2.2e-58 197.5 0.0 5.1e-54 183.2 0.0 4.2 4 0 0 4 4 4 1 Male sterility protein ADH_zinc_N PF00107.26 EEA06047.1 - 4e-54 182.1 0.0 2.8e-12 46.8 0.0 4.9 4 0 0 4 4 4 4 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EEA06047.1 - 5.6e-46 155.6 14.8 1.9e-06 28.3 0.0 7.9 7 0 0 7 7 7 7 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EEA06047.1 - 1.2e-34 119.5 21.6 1.4e-08 34.4 0.0 8.3 8 0 0 8 8 8 4 short chain dehydrogenase adh_short_C2 PF13561.6 EEA06047.1 - 7.7e-28 97.6 0.4 6.1e-07 29.2 0.0 4.8 4 0 0 4 4 4 4 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N_2 PF13602.6 EEA06047.1 - 1.1e-26 94.4 0.0 1.4e-06 29.4 0.0 5.2 4 1 0 4 4 4 4 Zinc-binding dehydrogenase Thiolase_N PF00108.23 EEA06047.1 - 5.4e-23 81.7 21.6 0.00051 19.5 0.2 7.5 7 0 0 7 7 7 7 Thiolase, N-terminal domain ADH_N PF08240.12 EEA06047.1 - 8.6e-21 73.9 4.8 0.00052 19.9 0.0 5.9 5 0 0 5 5 5 4 Alcohol dehydrogenase GroES-like domain GDP_Man_Dehyd PF16363.5 EEA06047.1 - 1.9e-13 50.5 6.2 0.0065 15.9 0.1 6.2 6 0 0 6 6 6 3 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EEA06047.1 - 6e-12 45.3 4.9 0.00024 20.4 0.0 5.3 5 0 0 5 5 5 3 Polysaccharide biosynthesis protein Epimerase PF01370.21 EEA06047.1 - 9.6e-09 35.0 0.4 4.5 6.7 0.0 6.8 7 0 0 7 7 7 2 NAD dependent epimerase/dehydratase family ACP_syn_III PF08545.10 EEA06047.1 - 1.1e-06 28.4 29.6 0.059 13.2 0.2 7.5 7 0 0 7 7 7 4 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III AlaDh_PNT_C PF01262.21 EEA06047.1 - 4.8e-06 26.0 0.1 0.47 9.7 0.0 3.9 4 0 0 4 4 4 2 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EEA06047.1 - 0.00012 22.3 7.5 11 6.3 0.0 7.0 8 0 0 8 8 6 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EEA06047.1 - 0.0034 17.5 0.0 0.59 10.2 0.0 3.2 3 0 0 3 3 2 1 Shikimate / quinate 5-dehydrogenase FAE1_CUT1_RppA PF08392.12 EEA06047.1 - 0.12 11.7 19.1 1.2 8.4 0.6 5.3 5 0 0 5 5 5 0 FAE1/Type III polyketide synthase-like protein Peptidase_M24 PF00557.24 EEA06048.1 - 4.8e-37 127.7 0.0 9.9e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 EEA06048.1 - 7.3e-34 117.2 2.5 4.8e-32 111.3 0.7 3.4 3 1 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EEA06048.1 - 1.7e-21 76.1 0.3 3.4e-21 75.1 0.3 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EEA06048.1 - 2.4e-14 54.1 0.0 1.3e-12 48.5 0.0 3.0 3 1 0 3 3 3 1 Creatinase/Prolidase N-terminal domain DUF1160 PF06648.11 EEA06048.1 - 0.02 14.9 1.5 0.19 11.7 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1160) DivIC PF04977.15 EEA06049.1 - 0.022 14.5 0.5 0.022 14.5 0.5 5.8 6 2 1 7 7 7 0 Septum formation initiator DUF4407 PF14362.6 EEA06049.1 - 0.18 11.2 8.8 1.2 8.4 3.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF5320 PF17253.2 EEA06049.1 - 0.47 11.5 8.8 6.8 7.8 0.2 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5320) AKNA PF12443.8 EEA06049.1 - 0.88 10.3 0.0 0.88 10.3 0.0 3.3 4 0 0 4 4 4 0 AT-hook-containing transcription factor PRKG1_interact PF15898.5 EEA06049.1 - 5.4 8.0 29.3 2.4 9.1 0.1 4.8 4 0 0 4 4 4 0 cGMP-dependent protein kinase interacting domain Fungal_lectin_2 PF18647.1 EEA06050.1 - 0.043 14.3 1.2 0.088 13.3 1.2 1.5 1 0 0 1 1 1 0 Alpha-galactosyl-binding fungal lectin Rsbr_N PF08678.10 EEA06050.1 - 8.2 6.5 10.6 1.1 9.3 2.3 3.2 3 2 0 3 3 3 0 Rsbr N terminal Vps52 PF04129.12 EEA06051.1 - 5e-20 71.7 34.6 2.7e-18 66.0 33.9 2.3 1 1 0 1 1 1 1 Vps52 / Sac2 family FlaC_arch PF05377.11 EEA06051.1 - 0.0029 17.9 3.3 0.011 16.1 3.3 2.0 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) DUF3683 PF12447.8 EEA06051.1 - 0.037 14.1 0.4 16 5.6 0.1 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3683) IL2RB_N1 PF18707.1 EEA06051.1 - 0.065 13.8 1.2 0.2 12.2 0.6 2.2 2 0 0 2 2 2 0 Interleukin-2 receptor subunit beta N-terminal domain 1 TrmE_N PF10396.9 EEA06051.1 - 0.1 12.9 0.0 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 GTP-binding protein TrmE N-terminus TPR_1 PF00515.28 EEA06052.1 - 6.2e-11 41.6 8.7 0.0019 18.0 0.6 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA06052.1 - 7.5e-09 35.0 6.6 0.075 13.2 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EEA06052.1 - 1.1e-08 35.1 3.1 2.6e-05 24.2 0.2 2.7 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EEA06052.1 - 1.1e-05 25.5 10.9 4e-05 23.7 6.8 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EEA06052.1 - 0.002 18.4 3.7 0.19 12.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EEA06052.1 - 0.0032 17.9 0.3 0.024 15.1 0.2 2.3 1 1 1 2 2 2 1 Alkyl sulfatase dimerisation TPR_8 PF13181.6 EEA06052.1 - 0.0035 17.4 7.2 0.49 10.7 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA06052.1 - 0.0046 17.5 2.6 3.5 8.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA06052.1 - 0.0051 17.4 0.4 2.5 8.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA06052.1 - 0.0067 16.9 0.9 0.12 12.9 0.1 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA06052.1 - 0.0069 16.2 0.1 0.83 9.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat HAGH_C PF16123.5 EEA06052.1 - 0.047 14.2 0.2 0.33 11.5 0.0 2.3 1 1 1 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus TPR_11 PF13414.6 EEA06052.1 - 0.051 13.3 0.2 0.051 13.3 0.2 3.6 4 0 0 4 4 4 0 TPR repeat TPR_7 PF13176.6 EEA06052.1 - 0.054 13.5 0.2 3.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA06052.1 - 0.1 13.5 0.2 8.6 7.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat AP2 PF00847.20 EEA06053.1 - 6.9e-09 35.8 2.8 3.9e-08 33.4 0.3 2.4 1 1 1 2 2 2 2 AP2 domain ERCC4 PF02732.15 EEA06054.1 - 3.9e-21 75.9 4.2 1.4e-20 74.1 0.0 3.2 3 1 0 3 3 3 1 ERCC4 domain CRAL_TRIO_2 PF13716.6 EEA06055.1 - 4.1e-30 104.7 0.5 1.1e-29 103.4 0.2 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EEA06055.1 - 4.1e-14 52.7 0.0 8.2e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO PF00650.20 EEA06055.1 - 0.023 14.4 0.2 0.089 12.5 0.2 1.9 1 1 0 1 1 1 0 CRAL/TRIO domain DEAD PF00270.29 EEA06056.1 - 1.5e-49 168.2 0.0 2.5e-49 167.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06056.1 - 1.5e-32 112.3 0.0 1e-31 109.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06056.1 - 0.023 14.7 0.0 0.051 13.6 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Tti2 PF10521.9 EEA06056.1 - 0.039 13.5 0.1 0.74 9.3 0.0 2.2 2 0 0 2 2 2 0 Tti2 family ERCC3_RAD25_C PF16203.5 EEA06056.1 - 0.15 11.3 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 EEA06056.1 - 0.19 12.0 0.1 4.4 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF4763 PF15960.5 EEA06057.1 - 0.00019 20.8 9.5 0.00019 20.8 9.5 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4763) RPW8 PF05659.11 EEA06057.1 - 0.00025 20.8 9.8 0.047 13.4 0.7 3.7 2 1 2 4 4 4 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 Atg14 PF10186.9 EEA06057.1 - 0.00048 19.3 12.6 0.00067 18.8 12.6 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 MAD PF05557.13 EEA06057.1 - 0.0015 17.0 19.4 0.027 12.9 12.6 2.0 1 1 1 2 2 2 2 Mitotic checkpoint protein ATG16 PF08614.11 EEA06057.1 - 0.0027 17.9 12.2 0.0027 17.9 12.2 2.2 2 1 0 2 2 1 1 Autophagy protein 16 (ATG16) Muted PF14942.6 EEA06057.1 - 0.0028 18.0 17.9 0.08 13.3 11.2 2.3 1 1 1 2 2 2 2 Organelle biogenesis, Muted-like protein FliJ PF02050.16 EEA06057.1 - 0.0032 17.7 9.3 0.052 13.8 5.2 2.6 2 1 1 3 3 2 2 Flagellar FliJ protein KASH_CCD PF14662.6 EEA06057.1 - 0.0058 16.5 16.7 0.0058 16.5 16.7 1.6 2 0 0 2 2 1 1 Coiled-coil region of CCDC155 or KASH WXG100 PF06013.12 EEA06057.1 - 0.007 16.6 7.3 1.5 9.1 0.1 4.1 4 0 0 4 4 4 1 Proteins of 100 residues with WXG Tropomyosin PF00261.20 EEA06057.1 - 0.011 15.1 2.7 0.011 15.1 2.7 2.4 1 1 0 2 2 2 0 Tropomyosin EzrA PF06160.12 EEA06057.1 - 0.013 13.7 23.0 0.038 12.2 3.0 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA HrpB7 PF09486.10 EEA06057.1 - 0.015 15.7 0.2 0.032 14.6 0.2 1.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Rx_N PF18052.1 EEA06057.1 - 0.017 15.4 1.2 0.017 15.4 1.2 2.9 1 1 1 2 2 2 0 Rx N-terminal domain Fez1 PF06818.15 EEA06057.1 - 0.017 15.6 17.3 0.15 12.5 4.6 2.4 1 1 1 2 2 2 0 Fez1 CENP-F_leu_zip PF10473.9 EEA06057.1 - 0.022 14.8 23.8 0.12 12.4 6.4 2.7 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rsm22 PF09243.10 EEA06057.1 - 0.025 13.8 1.5 0.045 13.0 1.5 1.4 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 FlaC_arch PF05377.11 EEA06057.1 - 0.028 14.8 22.7 0.17 12.3 4.8 4.1 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 EEA06057.1 - 0.042 14.0 23.7 0.8 9.9 4.6 3.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SesA PF17107.5 EEA06057.1 - 0.053 13.7 8.2 1.1 9.5 0.9 2.7 1 1 2 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Spc7 PF08317.11 EEA06057.1 - 0.062 12.2 21.6 0.15 10.9 4.8 2.6 1 1 2 3 3 3 0 Spc7 kinetochore protein PEP-utilisers_N PF05524.13 EEA06057.1 - 0.065 13.4 0.9 0.44 10.7 0.4 2.4 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal MscS_porin PF12795.7 EEA06057.1 - 0.067 12.7 16.4 0.54 9.8 4.0 2.6 2 1 1 3 3 2 0 Mechanosensitive ion channel porin domain DUF2730 PF10805.8 EEA06057.1 - 0.071 13.2 5.7 0.38 10.9 0.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF1732 PF08340.11 EEA06057.1 - 0.074 13.0 0.3 0.074 13.0 0.3 3.0 2 1 1 3 3 2 0 Domain of unknown function (DUF1732) DUF4618 PF15397.6 EEA06057.1 - 0.079 12.4 21.0 0.35 10.3 10.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) UTP15_C PF09384.10 EEA06057.1 - 0.087 12.5 0.2 0.087 12.5 0.2 2.5 3 0 0 3 3 3 0 UTP15 C terminal Golgin_A5 PF09787.9 EEA06057.1 - 0.11 12.0 19.2 0.026 14.0 15.1 1.7 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF948 PF06103.11 EEA06057.1 - 0.12 12.7 9.4 0.74 10.1 1.8 3.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) MtrB PF05440.12 EEA06057.1 - 0.17 12.3 2.5 4.8 7.7 0.1 2.9 3 0 0 3 3 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DHC PF09626.10 EEA06057.1 - 0.17 12.8 7.6 0.61 11.0 0.4 2.5 2 1 1 3 3 2 0 Dihaem cytochrome c DUF5320 PF17253.2 EEA06057.1 - 0.21 12.6 0.2 0.77 10.9 0.2 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Laminin_II PF06009.12 EEA06057.1 - 0.22 11.6 20.4 0.17 11.9 2.2 2.9 2 1 1 3 3 3 0 Laminin Domain II Phage_GP20 PF06810.11 EEA06057.1 - 0.22 11.3 22.3 0.13 12.1 8.0 3.4 2 1 2 4 4 3 0 Phage minor structural protein GP20 Pox_A_type_inc PF04508.12 EEA06057.1 - 0.28 11.1 8.1 5.6 7.0 0.3 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF4140 PF13600.6 EEA06057.1 - 0.3 11.5 4.9 1.4 9.4 0.3 2.8 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) PKcGMP_CC PF16808.5 EEA06057.1 - 0.3 11.0 6.8 42 4.1 0.0 4.7 2 2 2 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FAA_hydro_N_2 PF18288.1 EEA06057.1 - 0.33 11.4 0.2 0.33 11.4 0.2 3.7 2 2 2 4 4 3 0 Fumarylacetoacetase N-terminal domain 2 DUF3800 PF12686.7 EEA06057.1 - 0.39 11.4 4.5 1.3 9.6 4.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) NPV_P10 PF05531.12 EEA06057.1 - 0.51 10.8 14.8 1 9.8 1.0 3.7 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EEA06057.1 - 0.65 10.1 14.5 4.4 7.3 1.8 3.7 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) TF_AP-2 PF03299.14 EEA06057.1 - 0.79 9.7 6.9 0.2 11.6 1.1 2.4 2 1 0 2 2 2 0 Transcription factor AP-2 CHD5 PF04420.14 EEA06057.1 - 0.86 9.5 8.4 2 8.3 0.7 3.1 2 1 1 3 3 3 0 CHD5-like protein DUF1515 PF07439.11 EEA06057.1 - 0.87 9.6 2.8 1.9 8.5 0.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1515) Tropomyosin_1 PF12718.7 EEA06057.1 - 0.94 9.6 23.6 0.16 12.2 17.7 2.5 2 1 0 2 2 2 0 Tropomyosin like L31 PF09784.9 EEA06057.1 - 0.97 9.9 3.4 10 6.6 0.0 2.6 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 Sulfatase_C PF14707.6 EEA06057.1 - 1.1 10.1 3.6 2.4 8.9 0.7 2.7 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase Rop-like PF05082.13 EEA06057.1 - 1.1 9.1 7.1 0.23 11.3 1.2 2.7 3 0 0 3 3 2 0 Rop-like KxDL PF10241.9 EEA06057.1 - 1.1 9.5 14.2 0.16 12.3 1.0 3.5 2 1 1 4 4 3 0 Uncharacterized conserved protein G10 PF01125.17 EEA06057.1 - 1.2 8.9 6.1 0.88 9.3 2.4 2.2 2 1 0 2 2 2 0 G10 protein P4Ha_N PF08336.11 EEA06057.1 - 1.3 9.0 18.6 0.062 13.3 3.4 3.0 2 1 0 2 2 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TMPIT PF07851.13 EEA06057.1 - 1.5 8.0 16.7 0.45 9.7 1.9 2.5 1 1 2 3 3 3 0 TMPIT-like protein Exonuc_VII_L PF02601.15 EEA06057.1 - 1.6 8.2 15.6 0.26 10.8 4.4 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit Occludin_ELL PF07303.13 EEA06057.1 - 1.7 9.4 13.4 6.1 7.6 1.1 3.9 1 1 4 5 5 5 0 Occludin homology domain Snapin_Pallidin PF14712.6 EEA06057.1 - 1.7 9.1 15.9 2.1 8.8 1.3 3.6 3 1 1 4 4 4 0 Snapin/Pallidin HU-CCDC81_bac_2 PF18175.1 EEA06057.1 - 1.8 8.5 7.6 2.1 8.3 0.5 3.4 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 YtxH PF12732.7 EEA06057.1 - 2.1 9.0 5.5 66 4.1 5.0 3.2 1 1 0 1 1 1 0 YtxH-like protein Swi5 PF07061.11 EEA06057.1 - 2.1 8.5 15.3 2.8 8.1 2.4 3.7 3 1 1 4 4 3 0 Swi5 Syntaxin-6_N PF09177.11 EEA06057.1 - 2.2 8.9 15.5 2.9 8.5 2.6 3.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Uds1 PF15456.6 EEA06057.1 - 2.6 8.2 12.2 3.8 7.7 2.9 3.0 1 1 2 3 3 3 0 Up-regulated During Septation PRKG1_interact PF15898.5 EEA06057.1 - 3 8.8 17.1 4.5e+02 1.8 17.1 3.1 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF4201 PF13870.6 EEA06057.1 - 3.1 7.5 21.3 4.5 7.0 3.8 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF745 PF05335.13 EEA06057.1 - 3.2 7.4 13.2 1 9.0 0.7 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Phage_GPO PF05929.11 EEA06057.1 - 3.5 7.2 14.0 0.94 9.0 4.7 2.7 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Cauli_AT PF03233.13 EEA06057.1 - 3.5 7.5 19.8 0.15 12.0 1.3 3.2 1 1 1 3 3 3 0 Aphid transmission protein APG6_N PF17675.1 EEA06057.1 - 3.7 8.1 19.8 0.77 10.3 12.3 2.6 1 1 1 2 2 1 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 EEA06057.1 - 3.9 7.8 24.1 0.75 10.1 5.2 4.0 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Med9 PF07544.13 EEA06057.1 - 5.1 7.3 14.3 15 5.7 0.8 3.3 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 CLZ PF16526.5 EEA06057.1 - 5.5 7.4 13.0 4.4 7.7 0.8 3.5 3 1 1 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF16 PF01519.16 EEA06057.1 - 6.1 7.4 19.5 0.32 11.5 3.3 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 DUF2203 PF09969.9 EEA06057.1 - 6.5 7.5 11.7 9.5 7.0 1.6 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Uso1_p115_C PF04871.13 EEA06057.1 - 7 7.0 19.9 11 6.4 0.9 3.0 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region HIP1_clath_bdg PF16515.5 EEA06057.1 - 7.6 7.2 17.7 3.6 8.2 6.1 3.0 1 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 V_ATPase_I PF01496.19 EEA06057.1 - 8.3 4.2 18.7 1.1e+02 0.4 18.8 2.0 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Allexi_40kDa PF05549.11 EEA06057.1 - 9.7 5.6 13.8 1.9 7.9 4.6 2.5 1 1 1 2 2 2 0 Allexivirus 40kDa protein Abhydrolase_2 PF02230.16 EEA06058.1 - 0.0011 18.8 0.1 0.002 18.0 0.1 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 EEA06058.1 - 0.0037 17.2 0.3 0.0083 16.1 0.3 1.6 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 EEA06059.1 - 0.0001 22.2 0.0 0.0015 18.4 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EEA06059.1 - 0.045 13.0 0.1 2.8 7.1 0.0 2.8 2 1 1 3 3 3 0 Serine aminopeptidase, S33 DLH PF01738.18 EEA06059.1 - 0.056 13.0 0.0 0.14 11.7 0.0 1.6 1 1 1 2 2 2 0 Dienelactone hydrolase family Aminotran_5 PF00266.19 EEA06060.1 - 2.8e-82 276.7 0.0 3.5e-82 276.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EEA06060.1 - 8.9e-06 25.2 0.0 1.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EEA06060.1 - 2.5e-05 23.7 0.0 4.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EEA06060.1 - 0.00099 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 EEA06060.1 - 0.0024 16.6 0.0 0.0036 16.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Metallophos_3 PF14582.6 EEA06060.1 - 0.038 13.3 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily DUF724 PF05266.14 EEA06060.1 - 0.18 11.6 0.1 0.34 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Abhydrolase_2 PF02230.16 EEA06061.1 - 4.8e-06 26.5 0.0 1.1e-05 25.4 0.0 1.5 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EEA06061.1 - 0.039 13.6 0.0 0.074 12.7 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 EEA06061.1 - 0.05 13.1 0.0 0.078 12.5 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family FeoB_C PF07664.12 EEA06062.1 - 0.081 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B C terminus O-antigen_lig PF13425.6 EEA06062.1 - 0.23 10.2 1.0 0.26 10.0 1.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Conotoxin PF02950.17 EEA06062.1 - 0.28 12.2 1.0 0.59 11.2 1.0 1.8 1 1 0 1 1 1 0 Conotoxin Ribosomal_S27 PF01599.19 EEA06063.1 - 4.9e-23 81.0 1.4 4.9e-23 81.0 1.4 1.6 2 0 0 2 2 2 1 Ribosomal protein S27a ubiquitin PF00240.23 EEA06063.1 - 9e-05 22.1 0.1 0.00026 20.7 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 EEA06063.1 - 0.0023 18.4 0.8 0.031 14.7 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-like domain IBR PF01485.21 EEA06063.1 - 0.013 15.7 0.5 0.021 15.0 0.5 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain EB PF01683.18 EEA06064.1 - 2.1e-05 24.7 46.7 0.55 10.6 0.0 11.6 8 5 1 9 9 9 3 EB module Antistasin PF02822.14 EEA06064.1 - 0.21 12.3 64.7 1.5 9.5 1.3 13.9 8 5 4 12 12 12 0 Antistasin family Prok-E2_C PF14459.6 EEA06064.1 - 0.21 11.7 3.1 7.7 6.7 0.0 4.0 2 1 0 3 3 3 0 Prokaryotic E2 family C FOG_N PF15888.5 EEA06064.1 - 0.21 11.9 53.3 0.61 10.5 0.1 12.4 4 3 11 16 16 16 0 Folded gastrulation N-terminus UPF0179 PF03684.13 EEA06064.1 - 0.55 10.1 0.0 0.55 10.1 0.0 3.9 4 2 1 5 5 5 0 Uncharacterised protein family (UPF0179) cEGF PF12662.7 EEA06064.1 - 1.6 8.8 80.6 1.1 9.2 0.1 15.8 15 2 1 16 16 16 0 Complement Clr-like EGF-like CPW_WPC PF09717.10 EEA06064.1 - 6.8 7.8 43.8 7.9 7.5 0.1 10.2 6 5 3 9 9 9 0 Plasmodium falciparum domain of unknown function (CPW_WPC) Guanylate_cyc PF00211.20 EEA06065.1 - 1.2e-19 70.7 0.0 6.7e-09 35.6 0.0 3.5 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain RNA_pol_3_Rpc31 PF11705.8 EEA06065.1 - 0.35 11.1 7.7 0.99 9.6 7.7 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TPT PF03151.16 EEA06066.1 - 5.1e-24 85.1 12.0 5.1e-24 85.1 12.0 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EEA06066.1 - 1.3e-07 31.9 25.0 0.00021 21.5 1.0 3.2 3 0 0 3 3 3 2 EamA-like transporter family Nucleos_tra2_C PF07662.13 EEA06066.1 - 0.0014 18.5 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus TMEM234 PF10639.9 EEA06066.1 - 0.0095 16.0 0.4 0.0095 16.0 0.4 2.1 2 0 0 2 2 2 1 Putative transmembrane family 234 PUNUT PF16913.5 EEA06066.1 - 0.032 13.5 16.5 0.87 8.7 16.5 2.3 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport eIF-6 PF01912.18 EEA06067.1 - 9.5e-77 256.8 2.3 1.3e-76 256.4 1.8 1.4 1 1 1 2 2 2 1 eIF-6 family WD40 PF00400.32 EEA06068.1 - 2.6e-28 97.7 15.8 5.4e-07 30.2 0.8 6.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06068.1 - 4.6e-09 36.5 1.5 0.012 15.9 0.0 4.9 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 EEA06068.1 - 0.053 11.5 0.2 0.66 7.9 0.0 2.2 1 1 1 3 3 3 0 IKI3 family Cullin PF00888.22 EEA06069.1 - 3.7e-130 435.4 11.6 3.7e-130 435.4 11.6 1.9 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EEA06069.1 - 4.8e-22 77.8 2.2 4.8e-22 77.8 2.2 3.2 3 0 0 3 3 3 1 Cullin protein neddylation domain EMP24_GP25L PF01105.24 EEA06069.1 - 0.011 15.6 3.4 0.025 14.5 2.4 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Mcp5_PH PF12814.7 EEA06069.1 - 0.021 15.0 0.0 0.064 13.4 0.0 1.8 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology DUF772 PF05598.11 EEA06069.1 - 0.11 12.5 0.2 0.31 11.1 0.2 1.8 1 0 0 1 1 1 0 Transposase domain (DUF772) Ribosomal_S3Ae PF01015.18 EEA06070.1 - 5.6e-85 284.0 0.7 6.7e-85 283.8 0.7 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 EEA06070.1 - 0.027 14.0 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Tim17 PF02466.19 EEA06072.1 - 2e-13 50.7 6.5 2.9e-13 50.2 6.5 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DEAD PF00270.29 EEA06073.1 - 5.5e-48 163.0 0.1 8.8e-48 162.4 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06073.1 - 8.1e-29 100.2 0.3 9.2e-28 96.8 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06073.1 - 8.3e-07 29.2 0.0 2.7e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA06073.1 - 4e-06 26.2 0.2 6.5e-06 25.5 0.2 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.14 EEA06073.1 - 0.038 14.0 0.0 0.096 12.7 0.0 1.7 1 1 0 1 1 1 0 Flavivirus DEAD domain LSM PF01423.22 EEA06074.1 - 8.6e-18 63.8 1.0 1.3e-17 63.3 0.9 1.4 1 1 0 1 1 1 1 LSM domain Hfq PF17209.3 EEA06074.1 - 0.024 14.3 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Hfq protein DNAJ_related PF12339.8 EEA06075.1 - 0.03 14.5 0.4 0.066 13.4 0.4 1.6 1 1 1 2 2 2 0 DNA-J related protein Casc1_N PF15927.5 EEA06075.1 - 0.036 13.8 2.1 0.037 13.7 2.1 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Aquarius_N PF16399.5 EEA06076.1 - 3.9e-65 220.4 13.3 5.2e-64 216.6 13.3 2.3 1 1 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EEA06076.1 - 7.7e-35 120.3 0.0 2.2e-34 118.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EEA06076.1 - 2.1e-22 80.1 0.0 5.3e-22 78.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA06076.1 - 1.4e-08 35.2 0.0 2.2e-07 31.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA06076.1 - 2.2e-08 34.1 0.0 1.1e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EEA06076.1 - 2.8e-05 24.4 0.2 0.0004 20.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 EEA06076.1 - 3.9e-05 23.5 0.2 0.0021 17.8 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 EEA06076.1 - 0.00022 20.9 1.3 0.0086 15.6 1.3 2.5 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 EEA06076.1 - 0.00024 20.5 0.1 0.0012 18.2 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EEA06076.1 - 0.0011 18.4 0.0 0.0038 16.7 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 EEA06076.1 - 0.0014 18.6 0.0 0.0035 17.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA06076.1 - 0.0023 17.1 0.0 0.004 16.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Parvo_NS1 PF01057.17 EEA06076.1 - 0.0026 16.9 0.0 0.005 16.0 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_18 PF13238.6 EEA06076.1 - 0.004 17.7 0.0 0.07 13.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EEA06076.1 - 0.0053 16.6 0.0 0.055 13.3 0.0 2.2 2 0 0 2 2 2 1 Helicase AAA PF00004.29 EEA06076.1 - 0.0064 16.9 0.1 0.033 14.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA06076.1 - 0.035 14.5 0.0 0.19 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 EEA06076.1 - 0.041 13.4 0.0 0.36 10.3 0.0 2.5 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_23 PF13476.6 EEA06076.1 - 0.044 14.3 2.0 0.92 10.0 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EEA06076.1 - 0.045 13.9 0.0 0.088 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA06076.1 - 0.08 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DnaB_C PF03796.15 EEA06076.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RNA_pol_L_2 PF13656.6 EEA06077.1 - 3e-36 123.0 0.1 4.9e-36 122.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EEA06077.1 - 1.9e-06 27.2 0.0 4.2e-06 26.1 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF5329 PF17263.2 EEA06077.1 - 0.088 13.0 0.1 0.25 11.6 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5329) Kdo PF06293.14 EEA06078.1 - 0.067 12.5 0.0 0.099 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF792 PF05632.11 EEA06078.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) Histone PF00125.24 EEA06079.1 - 2.5e-52 176.7 1.1 2.8e-52 176.5 1.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EEA06079.1 - 0.00019 21.5 0.1 0.0003 20.9 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EEA06079.1 - 0.00026 21.3 0.0 0.00038 20.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EEA06079.1 - 0.00095 19.8 3.2 0.0012 19.4 3.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EEA06079.1 - 0.035 14.4 0.0 0.059 13.7 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EEA06079.1 - 0.057 13.5 0.0 0.088 12.9 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit NIF PF03031.18 EEA06081.1 - 2.7e-41 140.9 0.2 8.8e-41 139.3 0.1 1.9 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase TRM PF02005.16 EEA06082.1 - 3.5e-90 302.9 0.1 8.5e-68 229.2 0.0 2.2 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EEA06082.1 - 0.04 13.7 0.0 0.076 12.8 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein RNA_pol_N PF01194.17 EEA06083.1 - 2.1e-30 104.8 0.3 2.5e-30 104.5 0.3 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit HSP70 PF00012.20 EEA06084.1 - 7.2e-113 377.9 0.0 1e-112 377.4 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA06084.1 - 7.6e-09 34.8 0.7 3.1e-08 32.8 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Glu_dehyd_C PF16912.5 EEA06084.1 - 0.0058 16.1 0.0 0.06 12.8 0.0 2.1 1 1 1 2 2 2 1 Glucose dehydrogenase C-terminus FGGY_C PF02782.16 EEA06084.1 - 0.0074 16.0 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain RLL PF10036.9 EEA06084.1 - 0.025 14.4 0.0 0.06 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein GATA PF00320.27 EEA06085.1 - 0.21 11.2 10.5 0.094 12.3 2.7 2.5 2 0 0 2 2 2 0 GATA zinc finger IMCp PF12314.8 EEA06086.1 - 1.2e-10 41.5 34.1 1.2e-10 41.5 34.1 3.4 2 1 1 3 3 3 2 Inner membrane complex protein IMCp PF12314.8 EEA06087.1 - 6.6e-11 42.3 37.7 5.4e-07 29.8 20.2 4.3 1 1 2 4 4 4 2 Inner membrane complex protein PGM_PMM_I PF02878.16 EEA06088.1 - 3.1e-12 46.4 0.0 2.8e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EEA06088.1 - 5.2e-05 23.4 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EEA06088.1 - 0.0032 18.1 0.3 0.063 13.9 0.3 3.0 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Y1_Tnp PF01797.16 EEA06088.1 - 0.03 14.4 0.0 14 5.8 0.0 2.6 2 0 0 2 2 2 0 Transposase IS200 like NOC3p PF07540.11 EEA06090.1 - 6.6e-19 68.2 0.1 4e-18 65.7 0.1 2.4 1 0 0 1 1 1 1 Nucleolar complex-associated protein Pkinase PF00069.25 EEA06091.1 - 5e-68 229.3 1.1 7.3e-68 228.8 1.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06091.1 - 2.4e-41 141.8 0.7 3.5e-41 141.2 0.7 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EEA06091.1 - 4.5e-31 104.1 11.9 5.4e-06 25.6 0.2 6.7 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 EEA06091.1 - 5e-31 107.0 5.5 1.6e-11 44.5 0.3 4.1 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 EEA06091.1 - 8.8e-28 93.8 9.8 1.3e-05 24.7 0.1 7.0 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.6 EEA06091.1 - 8.4e-21 73.6 14.7 0.00034 20.4 0.1 6.8 4 3 3 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.6 EEA06091.1 - 2.4e-20 71.1 13.9 2e-06 27.0 0.4 6.4 6 0 0 6 6 6 4 EF hand SPARC_Ca_bdg PF10591.9 EEA06091.1 - 4.6e-08 33.4 1.2 0.0019 18.5 0.0 3.5 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Kdo PF06293.14 EEA06091.1 - 7.9e-06 25.4 0.6 1.7e-05 24.3 0.6 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA06091.1 - 6.5e-05 22.4 0.0 0.00015 21.2 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.11 EEA06091.1 - 0.00018 20.6 1.9 0.00032 19.8 1.9 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 EEA06091.1 - 0.00022 20.2 0.2 0.00037 19.4 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase EF-hand_10 PF14788.6 EEA06091.1 - 0.00048 19.9 0.5 0.09 12.7 0.2 3.9 4 0 0 4 4 4 1 EF hand EF-hand_4 PF12763.7 EEA06091.1 - 0.0041 17.1 5.1 8.7 6.4 0.0 4.2 2 1 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand APH PF01636.23 EEA06091.1 - 0.011 15.7 0.2 0.63 9.9 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EEA06091.1 - 0.037 13.6 0.0 0.085 12.4 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Caleosin PF05042.13 EEA06091.1 - 0.15 12.0 2.8 57 3.6 0.0 4.2 4 0 0 4 4 4 0 Caleosin related protein PH PF00169.29 EEA06092.1 - 2.1e-12 47.5 0.6 1.7e-11 44.5 0.0 2.7 4 0 0 4 4 4 1 PH domain PH_6 PF15406.6 EEA06092.1 - 0.0025 18.1 0.0 0.0075 16.6 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EEA06092.1 - 0.0027 18.0 0.0 0.0098 16.1 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Mob1_phocein PF03637.17 EEA06093.1 - 6.6e-44 149.9 1.8 1.2e-43 149.1 1.8 1.4 1 0 0 1 1 1 1 Mob1/phocein family CAF1C_H4-bd PF12265.8 EEA06094.1 - 5.3e-15 55.4 0.1 1.1e-13 51.3 0.0 2.5 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EEA06094.1 - 5.6e-14 52.3 6.8 8.4e-06 26.4 0.9 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06094.1 - 1.4e-05 25.3 0.3 0.0021 18.3 0.1 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA06094.1 - 7.7e-05 22.7 0.6 0.00024 21.1 0.4 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Beach PF02138.18 EEA06097.1 - 1.3e-76 257.6 2.3 3.5e-71 239.8 1.9 2.3 2 0 0 2 2 2 2 Beige/BEACH domain DUF5531 PF17671.1 EEA06097.1 - 0.086 12.7 0.3 0.19 11.6 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5531) AMP-binding PF00501.28 EEA06098.1 - 1.7e-68 231.2 0.0 2.4e-68 230.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ChlI PF13541.6 EEA06098.1 - 0.2 11.5 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase RRM_1 PF00076.22 EEA06099.1 - 2.2e-50 168.4 0.3 3.5e-16 58.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA06099.1 - 1.5e-10 41.1 0.1 0.0033 17.5 0.0 3.7 3 0 0 3 3 3 2 RNA recognition motif WW PF00397.26 EEA06099.1 - 1.8e-09 37.5 1.7 4.4e-09 36.3 1.7 1.7 1 0 0 1 1 1 1 WW domain RRM_5 PF13893.6 EEA06099.1 - 3.1e-08 33.3 0.3 8.2e-05 22.2 0.0 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EEA06099.1 - 0.00069 19.6 0.0 3 7.9 0.0 3.9 4 0 0 4 4 4 1 RNA binding domain Nup35_RRM PF05172.13 EEA06099.1 - 0.034 14.1 0.6 0.19 11.7 0.1 2.4 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RL PF17797.1 EEA06099.1 - 0.082 12.9 0.2 14 5.7 0.0 2.8 2 1 0 2 2 2 0 RL domain PHM7_cyt PF14703.6 EEA06099.1 - 0.19 12.0 0.6 56 3.9 0.0 3.4 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Vps53_N PF04100.12 EEA06100.1 - 3.1e-40 138.3 28.8 7.8e-21 74.5 8.9 4.6 3 1 1 4 4 4 2 Vps53-like, N-terminal DUF3150 PF11348.8 EEA06100.1 - 0.015 14.5 0.1 0.035 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) DUF489 PF04356.12 EEA06100.1 - 0.018 15.0 0.3 0.091 12.8 0.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF489) Streptin-Immun PF11083.8 EEA06100.1 - 0.16 12.4 5.1 0.46 10.9 1.0 3.5 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein Snapin_Pallidin PF14712.6 EEA06100.1 - 0.21 12.0 5.2 3.6 8.1 0.0 4.1 3 1 0 3 3 3 0 Snapin/Pallidin DWNN PF08783.11 EEA06101.1 - 5.2 7.4 7.3 6.8 7.1 0.2 3.6 2 0 0 2 2 2 0 DWNN domain PD40 PF07676.12 EEA06102.1 - 0.041 13.8 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat DUF4070 PF13282.6 EEA06103.1 - 0.066 13.3 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4070) Urm1 PF09138.11 EEA06103.1 - 0.076 13.4 0.1 9.2 6.7 0.0 3.6 3 0 0 3 3 3 0 Urm1 (Ubiquitin related modifier) JHD PF17811.1 EEA06103.1 - 0.1 13.1 1.5 18 5.9 0.0 4.1 3 0 0 3 3 3 0 Jumonji helical domain TbpB_C PF17483.2 EEA06107.1 - 0.1 13.0 0.3 0.29 11.5 0.1 1.9 2 1 0 2 2 2 0 C-lobe handle domain of Tf-binding protein B Herpes_UL20 PF04544.12 EEA06109.1 - 0.031 14.7 1.0 0.054 13.9 0.1 1.9 2 0 0 2 2 2 0 Herpesvirus egress protein UL20 ApoLp-III PF07464.11 EEA06111.1 - 0.0071 16.4 11.3 0.023 14.8 0.1 4.1 3 0 0 3 3 3 2 Apolipophorin-III precursor (apoLp-III) Uds1 PF15456.6 EEA06111.1 - 3.7 7.7 7.9 43 4.3 0.0 3.1 2 0 0 2 2 2 0 Up-regulated During Septation Tsc35 PF15079.6 EEA06113.1 - 1.9 8.0 11.4 1.4 8.4 1.7 2.4 2 1 0 2 2 2 0 Testis-specific protein 35 LPD11 PF18824.1 EEA06115.1 - 0.0065 16.5 0.2 0.045 13.8 0.2 2.5 1 0 0 1 1 1 1 Large polyvalent protein-associated domain 11 PI-TkoII_IV PF18714.1 EEA06115.1 - 2.5 7.5 6.7 4.3 6.8 0.3 3.5 3 0 0 3 3 3 0 DNA polymerase II intein Domain IV IF2_N PF04760.15 EEA06119.1 - 0.044 13.6 0.2 0.069 13.0 0.2 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Pkinase PF00069.25 EEA06120.1 - 5.8e-33 114.4 0.0 3.4e-29 102.0 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06120.1 - 5.3e-11 42.3 0.0 4.7e-10 39.2 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EEA06120.1 - 0.012 15.2 1.5 1.3 8.5 0.1 2.9 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EEA06120.1 - 0.081 11.7 0.1 0.25 10.1 0.0 1.7 1 1 0 1 1 1 0 Fungal protein kinase Latarcin PF10279.9 EEA06120.1 - 0.09 13.2 2.2 0.091 13.2 0.4 2.0 2 0 0 2 2 2 0 Latarcin precursor Aconitase PF00330.20 EEA06121.1 - 5.3e-168 559.8 0.0 6.9e-168 559.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EEA06121.1 - 2.4e-36 125.0 0.0 5.5e-36 123.8 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain TPR_2 PF07719.17 EEA06122.1 - 1e-05 25.2 3.1 0.034 14.3 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA06122.1 - 0.00046 19.9 3.9 0.23 11.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA06122.1 - 0.015 15.9 0.0 0.99 10.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DCA16 PF15349.6 EEA06122.1 - 0.091 12.3 0.6 0.23 11.0 0.6 1.6 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 TPR_8 PF13181.6 EEA06122.1 - 0.22 11.8 3.7 17 5.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat BCNT PF07572.12 EEA06123.1 - 6.5e-20 71.0 2.1 6.5e-20 71.0 2.1 2.3 3 0 0 3 3 3 1 Bucentaur or craniofacial development MTS PF05175.14 EEA06124.1 - 1.2e-09 38.0 0.0 1.8e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EEA06124.1 - 1.1e-05 25.3 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA06124.1 - 0.00048 20.8 0.0 0.0008 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EEA06124.1 - 0.001 19.0 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA06124.1 - 0.001 19.7 0.0 0.0025 18.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EEA06124.1 - 0.0055 16.1 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EEA06124.1 - 0.012 15.6 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EEA06124.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain YokU PF14122.6 EEA06124.1 - 0.1 12.6 0.1 0.29 11.2 0.1 1.9 1 1 1 2 2 2 0 YokU-like protein, putative antitoxin eIF-3c_N PF05470.12 EEA06126.1 - 5.1e-117 391.7 26.7 3e-68 230.6 5.0 2.8 2 1 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EEA06126.1 - 8.7e-09 35.8 0.1 2.3e-07 31.3 0.1 2.8 2 0 0 2 2 2 1 PCI domain CotJB PF12652.7 EEA06126.1 - 0.19 11.9 1.0 1.8 8.8 0.1 2.9 2 0 0 2 2 2 0 CotJB protein Cbl_N2 PF02761.14 EEA06127.1 - 0.033 14.9 1.2 2.3 9.0 0.2 2.6 1 1 2 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain Methyltransf_8 PF05148.15 EEA06129.1 - 3.1e-50 171.1 0.6 1.1e-49 169.2 0.1 1.9 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EEA06129.1 - 1.7e-06 28.6 0.0 4.7e-06 27.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA06129.1 - 0.0037 17.1 0.0 0.013 15.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EEA06129.1 - 0.0073 15.9 0.1 0.4 10.2 0.0 2.9 2 1 1 3 3 3 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EEA06129.1 - 0.0073 17.0 0.0 0.056 14.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA06129.1 - 0.013 15.3 0.4 0.86 9.4 0.4 2.5 1 1 0 1 1 1 0 Methyltransferase domain TFIIE_alpha PF02002.17 EEA06130.1 - 5.5e-05 23.0 0.8 0.01 15.7 0.2 2.5 2 0 0 2 2 2 2 TFIIE alpha subunit zf-C2H2_6 PF13912.6 EEA06130.1 - 0.0014 18.6 2.1 0.08 13.0 0.1 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger HTH_11 PF08279.12 EEA06130.1 - 0.0024 17.8 0.1 0.0064 16.4 0.1 1.7 1 0 0 1 1 1 1 HTH domain TFIIE-A_C PF11521.8 EEA06130.1 - 0.018 15.3 0.0 0.045 14.1 0.0 1.7 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha DUF4428 PF14471.6 EEA06130.1 - 0.021 14.7 0.2 0.058 13.3 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) zf-BED PF02892.15 EEA06130.1 - 0.026 14.5 0.1 1.4 9.0 0.0 2.7 2 0 0 2 2 2 0 BED zinc finger zf-met PF12874.7 EEA06130.1 - 0.24 11.8 1.4 0.57 10.7 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-RRN7 PF11781.8 EEA06130.1 - 0.28 10.9 0.8 1.4 8.7 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF2959 PF11172.8 EEA06130.1 - 0.5 10.5 3.9 1.2 9.3 0.2 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2959) AP2 PF00847.20 EEA06131.1 - 0.00015 21.9 0.7 0.00048 20.3 0.7 1.9 1 0 0 1 1 1 1 AP2 domain Ank_2 PF12796.7 EEA06132.1 - 3.8e-20 72.3 0.3 4.6e-11 43.2 0.0 4.6 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA06132.1 - 3.1e-15 56.3 0.2 2.1e-07 31.3 0.0 4.5 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA06132.1 - 3.3e-13 49.4 0.6 9.5e-05 22.7 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EEA06132.1 - 3.1e-10 39.4 0.9 0.024 15.1 0.0 6.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EEA06132.1 - 4e-07 30.2 0.1 0.019 15.3 0.0 4.2 3 1 1 4 4 4 2 Ankyrin repeats (many copies) DUF2231 PF09990.9 EEA06132.1 - 4.5 7.8 5.5 0.5 10.8 0.5 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) Ank_2 PF12796.7 EEA06133.1 - 2.5e-12 47.2 1.7 3.4e-10 40.4 0.0 4.0 2 1 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA06133.1 - 2.7e-12 47.0 0.0 3.5e-09 37.0 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA06133.1 - 1.2e-08 34.5 0.4 0.038 14.5 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EEA06133.1 - 2e-08 34.3 0.3 0.00099 19.4 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EEA06133.1 - 6.8e-06 26.3 0.2 0.39 11.3 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat PIRT PF15099.6 EEA06133.1 - 0.024 14.2 1.6 0.1 12.2 1.6 2.0 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Cpn60_TCP1 PF00118.24 EEA06134.1 - 3.6e-163 543.7 0.9 4.1e-163 543.5 0.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ANAPC15 PF15243.6 EEA06134.1 - 0.095 13.1 0.1 0.24 11.8 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Cpn60_TCP1 PF00118.24 EEA06135.1 - 4.8e-155 516.9 1.5 5.4e-155 516.7 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glyco_transf_24 PF18404.1 EEA06136.1 - 3.1e-09 36.6 8.8 5e-09 36.0 7.0 2.3 1 1 1 2 2 2 1 Glucosyltransferase 24 Thioredoxin_13 PF18401.1 EEA06136.1 - 1e-06 28.7 0.0 1e-05 25.4 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like domain tRNA_bind PF01588.20 EEA06137.1 - 2.2e-27 95.0 0.1 4e-27 94.2 0.1 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.6 EEA06137.1 - 0.00091 19.4 0.1 0.0018 18.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EEA06137.1 - 0.0026 17.5 0.3 0.0056 16.4 0.3 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EEA06137.1 - 0.051 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF2989 PF11207.8 EEA06137.1 - 0.051 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) WD40 PF00400.32 EEA06138.1 - 8.2e-18 64.4 19.1 7.5e-05 23.4 1.4 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06138.1 - 9.5e-07 29.0 0.0 6.3 7.2 0.0 6.1 5 1 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain CSTF1_dimer PF16699.5 EEA06138.1 - 0.00025 20.7 0.0 0.00054 19.7 0.0 1.5 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain Cytochrom_D1 PF02239.16 EEA06138.1 - 0.0036 15.9 0.0 0.0062 15.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain Es2 PF09751.9 EEA06139.1 - 1.6e-20 74.3 18.0 3.8e-09 36.8 0.2 4.0 2 1 1 3 3 3 3 Nuclear protein Es2 Ribosomal_L24e PF01246.20 EEA06140.1 - 7e-28 96.7 0.8 1.5e-27 95.6 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e Ribosomal_L31 PF01197.18 EEA06140.1 - 0.0021 18.2 0.1 0.0038 17.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 WWE PF02825.20 EEA06142.1 - 2e-08 34.7 0.1 2e-08 34.7 0.1 2.0 2 0 0 2 2 2 1 WWE domain ZZ PF00569.17 EEA06144.1 - 6.2e-11 41.9 7.2 1.2e-10 41.0 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 EEA06144.1 - 1.2e-08 35.0 2.2 4.6e-08 33.1 0.0 2.8 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA06144.1 - 0.00023 21.4 0.0 0.00083 19.6 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain C1_2 PF03107.16 EEA06144.1 - 0.0024 18.1 3.7 0.0055 17.0 3.7 1.6 1 0 0 1 1 1 1 C1 domain DNA_pol_lambd_f PF10391.9 EEA06144.1 - 0.082 12.8 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda SF3b10 PF07189.11 EEA06145.1 - 2.3e-27 94.9 0.0 2.8e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) WD40 PF00400.32 EEA06146.1 - 8.5e-44 146.7 37.7 3.4e-06 27.7 0.0 10.0 10 0 0 10 10 10 8 WD domain, G-beta repeat Utp13 PF08625.11 EEA06146.1 - 7.7e-25 87.5 1.3 1.8e-24 86.3 1.3 1.6 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EEA06146.1 - 5.5e-15 55.4 1.9 5.1e-05 23.5 0.0 5.8 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA06146.1 - 0.00077 18.2 11.8 1.1 7.8 0.2 6.3 5 2 0 7 7 7 2 Nucleoporin Nup120/160 UTP15_C PF09384.10 EEA06146.1 - 0.021 14.5 0.4 2.4 7.8 0.0 2.3 1 1 1 2 2 2 0 UTP15 C terminal USP7_ICP0_bdg PF12436.8 EEA06146.1 - 0.036 13.4 0.1 0.063 12.6 0.1 1.3 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 His_Phos_2 PF00328.22 EEA06147.1 - 2.1e-15 57.0 0.2 9.6e-12 44.9 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Syntaxin_2 PF14523.6 EEA06147.1 - 2.7 8.4 5.2 10 6.6 0.2 3.1 3 0 0 3 3 3 0 Syntaxin-like protein PAP_central PF04928.17 EEA06148.1 - 1.4e-106 355.1 0.0 2.3e-106 354.3 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EEA06148.1 - 2.2e-19 69.7 5.6 2.4e-14 53.3 0.3 2.8 2 1 1 3 3 3 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EEA06148.1 - 9.6e-08 32.2 0.0 2.6e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF4834 PF16118.5 EEA06148.1 - 0.4 11.7 3.9 0.87 10.6 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4661 PF15576.6 EEA06148.1 - 2.8 7.8 4.1 5.3 6.9 3.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4661) WD40 PF00400.32 EEA06150.1 - 1.1e-24 86.2 13.5 3.8e-07 30.7 0.2 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06150.1 - 2.1e-10 40.8 0.0 0.26 11.6 0.0 6.0 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EEA06150.1 - 0.011 14.7 0.2 0.16 10.9 0.1 2.7 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PMM PF03332.13 EEA06151.1 - 3.2e-96 321.4 2.1 3.7e-96 321.2 2.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EEA06151.1 - 1e-10 41.8 0.7 3.4e-10 40.1 0.7 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PNK3P PF08645.11 EEA06151.1 - 0.025 14.3 0.3 3 7.5 0.0 2.8 2 1 1 3 3 3 0 Polynucleotide kinase 3 phosphatase S6PP PF05116.13 EEA06151.1 - 0.098 12.2 0.0 3.3 7.1 0.0 2.1 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase XTBD PF11952.8 EEA06151.1 - 0.14 11.9 0.2 0.26 11.1 0.2 1.4 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD MCM PF00493.23 EEA06152.1 - 3.9e-98 327.0 0.0 6.1e-98 326.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA06152.1 - 5.9e-26 90.8 1.3 1.2e-25 89.7 1.3 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA06152.1 - 1.8e-19 70.0 0.3 3.9e-19 68.8 0.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EEA06152.1 - 7.8e-09 35.2 0.2 1.3e-05 24.7 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EEA06152.1 - 1.6e-07 31.9 0.7 5.9e-07 30.0 0.0 2.3 2 0 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 EEA06152.1 - 2.6e-05 24.1 0.0 5.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA06152.1 - 5.5e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA06152.1 - 0.011 16.2 0.9 0.13 12.6 0.1 2.5 2 1 1 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.26 EEA06152.1 - 0.098 12.4 1.2 2.3 7.9 0.0 2.9 4 0 0 4 4 4 0 Sigma-54 interaction domain DUF1084 PF06454.11 EEA06153.1 - 1.4e-08 34.4 23.1 8.7e-06 25.3 15.9 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1084) HECT PF00632.25 EEA06155.1 - 4.8e-45 154.4 0.5 2.1e-44 152.2 0.1 2.4 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 EEA06155.1 - 4.3e-05 24.0 10.9 0.00041 20.9 1.4 5.5 5 0 0 5 5 5 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA06155.1 - 0.0016 19.0 1.5 0.013 16.0 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA06155.1 - 0.0018 18.6 0.9 0.025 14.9 0.2 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Rep_fac_C PF08542.11 EEA06155.1 - 0.36 11.3 1.7 33 5.0 0.1 3.0 2 0 0 2 2 2 0 Replication factor C C-terminal domain ATP-synt_ab PF00006.25 EEA06156.1 - 6.8e-104 346.2 0.0 9.4e-104 345.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EEA06156.1 - 9.5e-42 141.7 0.0 1.8e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EEA06156.1 - 9.1e-15 54.9 0.8 2.3e-14 53.7 0.8 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF2937 PF11157.8 EEA06156.1 - 0.046 13.4 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Coatomer_WDAD PF04053.14 EEA06157.1 - 1.5e-127 426.3 11.3 5.2e-127 424.6 4.6 2.5 2 1 0 2 2 2 2 Coatomer WD associated region WD40 PF00400.32 EEA06157.1 - 3.4e-37 125.8 11.7 1.2e-07 32.3 0.2 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06157.1 - 1.8e-07 31.3 2.6 0.22 11.9 0.0 5.7 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA06157.1 - 0.0016 17.1 0.9 0.017 13.8 0.0 2.4 2 1 0 2 2 2 1 Nucleoporin Nup120/160 SRX PF09201.10 EEA06157.1 - 0.062 13.1 0.7 1.8 8.3 0.4 2.7 2 0 0 2 2 2 0 SRX, signal recognition particle receptor alpha subunit TPR_1 PF00515.28 EEA06157.1 - 0.082 12.8 0.0 0.42 10.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat ubiquitin PF00240.23 EEA06158.1 - 1.6e-07 30.9 0.1 2.9e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EEA06158.1 - 8.5e-06 25.6 0.2 4.6e-05 23.2 0.0 2.5 2 0 0 2 2 2 1 UBA/TS-N domain HOIP-UBA PF16678.5 EEA06158.1 - 0.00087 19.3 0.0 0.0031 17.5 0.0 1.9 2 0 0 2 2 2 1 HOIP UBA domain pair STI1 PF17830.1 EEA06158.1 - 0.0013 18.6 6.0 0.0039 17.1 2.1 4.2 3 2 2 5 5 5 2 STI1 domain GerD PF17898.1 EEA06158.1 - 0.0093 15.9 1.5 0.018 15.0 0.2 2.2 2 1 0 2 2 2 1 Spore germination GerD central core domain DUF2407 PF10302.9 EEA06158.1 - 0.033 14.8 1.4 0.11 13.1 0.2 2.4 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain APOBEC_C PF05240.14 EEA06159.1 - 0.28 11.2 6.1 7.7 6.5 0.2 3.2 3 0 0 3 3 3 0 APOBEC-like C-terminal domain Pkinase PF00069.25 EEA06162.1 - 7.9e-59 199.2 0.0 1.7e-58 198.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06162.1 - 2.1e-40 138.6 0.0 4.8e-40 137.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA06162.1 - 2.1e-07 30.5 0.0 4.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA06162.1 - 8.5e-05 21.5 0.2 0.00084 18.2 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase EF-hand_11 PF08976.11 EEA06162.1 - 0.0005 20.9 0.1 0.0018 19.1 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 EEA06162.1 - 0.049 13.2 0.0 4.5 7.0 0.0 2.9 2 0 0 2 2 2 0 EF hand Ribosomal_S10 PF00338.22 EEA06163.1 - 1.7e-27 95.5 0.1 2.2e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PriA_C PF18074.1 EEA06163.1 - 0.021 15.6 0.1 0.034 15.0 0.1 1.5 1 1 0 1 1 1 0 Primosomal protein N C-terminal domain UB2H PF14814.6 EEA06163.1 - 0.085 12.9 0.0 4.2 7.5 0.0 2.1 1 1 1 2 2 2 0 Bifunctional transglycosylase second domain FeS_assembly_P PF01883.19 EEA06164.1 - 2e-09 37.5 0.5 7.3e-09 35.7 0.0 2.1 3 0 0 3 3 3 1 Iron-sulfur cluster assembly protein Wza_C PF18412.1 EEA06164.1 - 0.13 12.0 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Outer-membrane lipoprotein Wza C-terminal domain SET PF00856.28 EEA06166.1 - 1.4e-19 71.1 3.6 3.1e-19 70.0 3.6 1.6 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 EEA06166.1 - 1.6e-06 28.1 4.3 1.6e-06 28.1 4.3 4.4 5 0 0 5 5 5 1 MYND finger DUF3512 PF12024.8 EEA06166.1 - 0.17 11.4 1.0 0.42 10.1 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3512) TPR_14 PF13428.6 EEA06166.1 - 0.24 12.3 0.1 24 6.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat IRF-2BP1_2 PF11261.8 EEA06166.1 - 1.8 8.2 6.3 0.4 10.3 1.2 2.6 2 1 1 3 3 3 0 Interferon regulatory factor 2-binding protein zinc finger Thioredoxin PF00085.20 EEA06167.1 - 6.7e-20 71.0 0.2 6.6e-12 45.3 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EEA06167.1 - 3.1e-14 53.3 12.1 1.1e-09 38.5 1.4 3.6 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA06167.1 - 2.7e-07 30.3 5.0 2.9e-05 23.6 1.2 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EEA06167.1 - 1.2e-06 28.5 0.1 0.0016 18.4 0.0 2.9 2 0 0 2 2 2 2 AhpC/TSA family DUF836 PF05768.14 EEA06167.1 - 0.00023 21.5 2.3 0.049 14.1 0.0 3.2 3 1 1 4 4 4 2 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EEA06167.1 - 0.045 14.0 0.4 0.55 10.5 0.0 2.9 3 0 0 3 3 3 0 Glutaredoxin Thioredoxin_2 PF13098.6 EEA06167.1 - 0.46 11.0 5.7 3.6 8.1 0.3 4.2 3 2 1 4 4 4 0 Thioredoxin-like domain VASt PF16016.5 EEA06168.1 - 0.039 14.4 0.0 0.086 13.2 0.0 1.5 1 0 0 1 1 1 0 VAD1 Analog of StAR-related lipid transfer domain DUF3496 PF12001.8 EEA06168.1 - 0.14 12.5 0.0 0.41 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) VASt PF16016.5 EEA06169.1 - 0.00018 22.0 0.0 0.00037 20.9 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EEA06169.1 - 0.057 13.3 0.1 0.21 11.5 0.1 2.0 1 1 0 1 1 1 0 GRAM domain VPS11_C PF12451.8 EEA06170.1 - 0.056 13.7 0.4 0.35 11.1 0.4 2.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Cas9_PI2 PF18070.1 EEA06170.1 - 0.075 13.8 0.2 0.87 10.4 0.2 3.0 1 0 0 1 1 1 0 CRISPR-Cas9 PI domain Histidinol_dh PF00815.20 EEA06170.1 - 0.13 11.3 2.1 0.41 9.6 2.1 1.8 1 0 0 1 1 1 0 Histidinol dehydrogenase PH PF00169.29 EEA06171.1 - 0.0033 17.9 0.0 0.0059 17.1 0.0 1.3 1 0 0 1 1 1 1 PH domain VHL_C PF17211.3 EEA06171.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 VHL box domain PH_2 PF08458.10 EEA06171.1 - 0.2 12.0 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Lum_binding PF00677.17 EEA06172.1 - 0.063 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Lumazine binding domain RANK_CRD_2 PF18278.1 EEA06172.1 - 0.11 12.7 4.5 28 4.9 0.1 4.7 4 0 0 4 4 4 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 CBM_14 PF01607.24 EEA06172.1 - 0.34 11.1 53.6 1.6 9.0 0.9 12.0 5 2 8 13 13 13 0 Chitin binding Peritrophin-A domain cEGF PF12662.7 EEA06172.1 - 0.38 10.7 23.6 4.1 7.4 0.1 8.1 8 1 0 8 8 8 0 Complement Clr-like EGF-like RRM_1 PF00076.22 EEA06173.1 - 2.9e-11 43.0 0.2 7.4e-11 41.7 0.2 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA06173.1 - 0.0044 16.6 0.2 0.0054 16.3 0.2 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA06173.1 - 0.075 12.9 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif dUTPase PF00692.19 EEA06174.1 - 3.2e-15 56.0 0.0 4.3e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 dUTPase DUF1674 PF07896.12 EEA06175.1 - 4.7e-09 36.6 0.3 6.3e-09 36.2 0.3 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) JAB PF01398.21 EEA06176.1 - 2.1e-05 24.5 0.4 2.1e-05 24.5 0.4 2.9 2 1 1 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Rhomboid_N PF12122.8 EEA06176.1 - 0.065 13.4 0.4 0.065 13.4 0.4 2.4 2 1 0 2 2 2 0 Cytoplasmic N-terminal domain of rhomboid serine protease Bromodomain PF00439.25 EEA06179.1 - 3.2e-19 68.8 0.6 1.9e-18 66.3 0.0 2.2 1 1 1 2 2 2 1 Bromodomain s48_45 PF07422.13 EEA06179.1 - 0.23 12.0 3.9 1.1 9.9 0.0 2.7 2 1 0 2 2 2 0 Sexual stage antigen s48/45 domain RRM_1 PF00076.22 EEA06180.1 - 1.2e-36 124.3 0.5 7e-16 57.8 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EEA06180.1 - 0.00049 21.1 2.3 0.026 15.6 0.4 2.8 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_7 PF16367.5 EEA06180.1 - 0.0092 16.1 0.0 0.044 13.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 EEA06180.1 - 0.01 15.4 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EEA06180.1 - 0.016 15.4 0.0 0.47 10.7 0.0 2.5 2 0 0 2 2 2 0 BRCA1-associated protein 2 Tyr_Deacylase PF02580.16 EEA06181.1 - 1.8e-46 158.2 0.0 2e-46 158.1 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Cucumo_coat PF00760.18 EEA06182.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Cucumovirus coat protein Bac_RepA_C PF18008.1 EEA06182.1 - 0.38 11.1 5.0 0.73 10.2 0.1 3.3 4 0 0 4 4 4 0 Replication initiator protein A C-terminal domain Methyltransf_16 PF10294.9 EEA06183.1 - 5.5e-25 88.1 0.2 1.1e-24 87.1 0.2 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Ank_2 PF12796.7 EEA06183.1 - 1.5e-20 73.6 2.4 3.2e-14 53.3 0.3 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EEA06183.1 - 5.3e-16 58.3 1.0 3.4e-06 27.3 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EEA06183.1 - 3.3e-14 53.0 0.4 8.2e-11 42.2 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA06183.1 - 3.6e-12 45.3 0.3 0.001 19.3 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EEA06183.1 - 2.8e-11 43.4 0.1 9.1e-07 29.0 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) MTS PF05175.14 EEA06183.1 - 4.9e-05 23.0 0.0 0.00077 19.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EEA06183.1 - 0.044 14.5 0.0 0.56 10.9 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 EEA06183.1 - 0.074 12.9 0.0 0.19 11.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EEA06183.1 - 0.15 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Drf_GBD PF06371.13 EEA06184.1 - 0.0051 16.4 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain EIF_2_alpha PF07541.12 EEA06185.1 - 2.8e-29 101.6 0.4 3.3e-28 98.1 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EEA06185.1 - 3.7e-13 49.6 0.7 3.7e-13 49.6 0.7 1.9 2 0 0 2 2 2 1 S1 RNA binding domain Myb_DNA-bind_4 PF13837.6 EEA06185.1 - 0.13 12.7 0.3 0.36 11.3 0.3 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain POB3_N PF17292.2 EEA06186.1 - 1.2e-25 89.8 0.9 4.2e-22 78.4 0.2 3.3 3 0 0 3 3 3 2 POB3-like N-terminal PH domain Rtt106 PF08512.12 EEA06186.1 - 1.1e-22 80.2 1.4 4e-22 78.4 0.1 2.6 3 0 0 3 3 3 1 Histone chaperone Rttp106-like SSrecog PF03531.14 EEA06186.1 - 5.2e-19 67.9 0.3 2e-18 66.0 0.1 2.1 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) XRCC4 PF06632.12 EEA06186.1 - 0.088 11.6 6.2 0.13 11.1 6.2 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Cwf_Cwc_15 PF04889.12 EEA06186.1 - 1.9 8.2 13.2 3.7 7.2 13.2 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.13 EEA06186.1 - 3.9 7.4 15.7 5.9 6.8 15.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hint PF01079.20 EEA06187.1 - 2.9e-20 72.7 0.0 7.6e-20 71.3 0.0 1.6 1 1 0 1 1 1 1 Hint module PPTA PF01239.22 EEA06188.1 - 2.1e-30 103.5 23.7 1e-08 34.6 0.2 6.2 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat Ribosomal_L24e PF01246.20 EEA06189.1 - 1.7e-32 111.5 7.9 3.6e-32 110.4 7.9 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FCS PF06467.14 EEA06189.1 - 0.0048 16.8 3.7 0.012 15.5 3.4 1.9 1 1 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif VKOR PF07884.14 EEA06191.1 - 0.00048 20.3 5.0 0.00048 20.3 5.0 1.7 2 0 0 2 2 2 1 Vitamin K epoxide reductase family DUF1064 PF06356.11 EEA06191.1 - 1.3 9.4 11.2 0.065 13.6 1.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1064) DUF2070 PF09843.9 EEA06191.1 - 2.6 6.2 9.0 3.8 5.7 9.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Glyco_transf_36 PF06165.11 EEA06192.1 - 0.058 12.8 0.8 0.11 11.8 0.0 1.8 3 0 0 3 3 3 0 Glycosyltransferase family 36 Nod1 PF17114.5 EEA06192.1 - 0.074 13.2 2.1 0.11 12.7 0.2 2.2 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 AKNA PF12443.8 EEA06192.1 - 0.2 12.3 0.5 13 6.6 0.1 2.9 3 0 0 3 3 3 0 AT-hook-containing transcription factor LSM PF01423.22 EEA06193.1 - 1.5e-14 53.4 0.1 2e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain HU-CCDC81_euk_1 PF14908.6 EEA06194.1 - 0.094 12.9 0.1 0.28 11.4 0.1 1.8 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 AKAP7_NLS PF10469.9 EEA06195.1 - 1.6e-27 96.8 1.1 2.9e-27 95.9 1.1 1.4 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain LigT_PEase PF02834.16 EEA06195.1 - 0.0028 17.8 0.3 2.8 8.2 0.0 3.7 2 2 1 3 3 3 1 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 EEA06195.1 - 0.043 13.7 0.0 0.18 11.7 0.0 1.8 1 1 1 2 2 2 0 2'-5' RNA ligase superfamily SAE2 PF08573.10 EEA06196.1 - 3.5e-08 34.5 4.4 2.6e-05 25.3 0.9 4.0 2 2 1 3 3 3 1 DNA repair protein endonuclease SAE2/CtIP C-terminus vWF_A PF12450.8 EEA06196.1 - 0.02 14.8 0.1 3.7 7.6 0.1 2.6 2 0 0 2 2 2 0 von Willebrand factor Jnk-SapK_ap_N PF09744.9 EEA06196.1 - 0.15 12.3 0.3 0.15 12.3 0.3 1.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 HALZ PF02183.18 EEA06196.1 - 0.72 10.1 3.1 3.8 7.8 0.2 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper WD40 PF00400.32 EEA06198.1 - 2.1e-13 50.5 6.9 0.004 18.0 0.3 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06198.1 - 8.7e-10 38.8 0.1 0.0043 17.3 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EEA06198.1 - 7.3e-05 22.8 0.1 0.36 10.9 0.0 3.7 3 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 EEA06198.1 - 0.0095 14.9 0.0 5.1 6.0 0.0 3.3 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Inhibitor_I36 PF03995.13 EEA06198.1 - 0.024 14.5 2.6 0.1 12.6 2.6 2.0 1 0 0 1 1 1 0 Peptidase inhibitor family I36 RMI1_N PF08585.12 EEA06199.1 - 8.3e-15 55.1 0.4 4.8e-14 52.6 0.4 2.2 1 1 0 1 1 1 1 RecQ mediated genome instability protein Terminase_3C PF17288.2 EEA06199.1 - 0.038 14.4 0.3 0.095 13.1 0.3 1.6 1 0 0 1 1 1 0 Terminase RNAseH like domain KKLCAg1 PF15204.6 EEA06201.1 - 7.6 6.7 10.1 3.6 7.8 0.4 4.5 3 0 0 3 3 3 0 Kita-kyushu lung cancer antigen 1 Sigma_reg_N PF13800.6 EEA06202.1 - 0.061 13.6 2.0 0.095 13.0 0.9 1.9 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Vps16_N PF04841.13 EEA06203.1 - 1e-43 149.6 0.2 4.6e-43 147.5 0.1 2.1 2 0 0 2 2 2 1 Vps16, N-terminal region Vps16_C PF04840.12 EEA06203.1 - 1.3e-20 73.7 6.0 6.9e-13 48.3 0.2 2.6 1 1 1 3 3 3 2 Vps16, C-terminal region Clathrin PF00637.20 EEA06203.1 - 0.00041 20.2 3.7 0.0012 18.7 1.8 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS DUF1938 PF09153.10 EEA06205.1 - 0.0018 18.3 0.1 0.011 15.8 0.1 2.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1938) Plant_all_beta PF10532.9 EEA06205.1 - 0.015 15.5 0.6 0.045 14.0 0.6 1.8 1 0 0 1 1 1 0 Plant specific N-all beta domain Prp18 PF02840.15 EEA06207.1 - 8.2e-56 188.0 1.8 8.2e-56 188.0 1.8 2.3 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EEA06207.1 - 1.1e-11 44.0 0.0 2.3e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like RNA_pol_N PF01194.17 EEA06207.1 - 0.1 12.9 0.1 0.41 11.0 0.1 2.2 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit DUF4140 PF13600.6 EEA06207.1 - 4.7 7.7 6.0 2.7 8.5 0.2 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ALMT PF11744.8 EEA06207.1 - 5 5.8 7.2 4.8 5.9 3.2 2.0 1 1 0 2 2 2 0 Aluminium activated malate transporter Thioredoxin_11 PF18078.1 EEA06207.1 - 5.4 7.2 8.9 40 4.3 0.7 3.8 3 1 1 4 4 4 0 Thioredoxin-like SNTX domain DUF3139 PF11337.8 EEA06209.1 - 0.0024 18.5 0.1 0.013 16.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3139) DUF2013 PF09431.10 EEA06209.1 - 0.28 11.3 2.9 6 7.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2013) SF3A2 PF16835.5 EEA06210.1 - 3e-17 62.8 0.6 4.5e-17 62.2 0.6 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) Methyltransf_31 PF13847.6 EEA06211.1 - 3.8e-10 39.8 5.1 2.5e-09 37.1 0.4 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA06211.1 - 6.6e-10 39.6 0.0 1.8e-05 25.4 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EEA06211.1 - 6.6e-08 33.1 0.0 0.00054 20.5 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase domain Spermine_synth PF01564.17 EEA06211.1 - 7.5e-07 28.7 3.4 9.2e-06 25.2 0.1 2.6 2 1 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EEA06211.1 - 0.00018 21.4 0.0 0.018 14.9 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EEA06211.1 - 0.00041 20.4 0.0 0.036 14.1 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain RRN3 PF05327.11 EEA06212.1 - 2.4e-20 72.6 4.3 4.1e-20 71.9 4.3 1.3 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF3223 PF11523.8 EEA06212.1 - 0.0016 19.2 0.2 0.0065 17.3 0.2 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) Gtr1_RagA PF04670.12 EEA06213.1 - 1.4e-83 279.8 2.4 1.8e-83 279.5 2.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EEA06213.1 - 4.6e-06 26.8 0.0 1.7e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA06213.1 - 5.2e-05 22.8 0.0 9.3e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EEA06213.1 - 7.4e-05 22.4 0.1 0.0005 19.7 0.0 2.1 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 EEA06213.1 - 0.0017 18.5 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_pol_Rpb1_1 PF04997.12 EEA06213.1 - 0.0096 15.3 0.3 0.04 13.2 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 ABC_tran PF00005.27 EEA06213.1 - 0.021 15.3 0.2 0.053 14.0 0.2 2.0 1 1 0 1 1 1 0 ABC transporter SRP14 PF02290.15 EEA06214.1 - 1.2e-07 32.0 0.7 1.4e-07 31.8 0.7 1.1 1 0 0 1 1 1 1 Signal recognition particle 14kD protein Syntaxin_2 PF14523.6 EEA06214.1 - 0.32 11.4 7.3 27 5.2 7.3 2.1 1 1 0 1 1 1 0 Syntaxin-like protein Skp1_POZ PF03931.15 EEA06215.1 - 1.2e-05 25.3 0.7 0.00012 22.2 0.3 2.4 2 1 0 2 2 2 1 Skp1 family, tetramerisation domain Kinesin PF00225.23 EEA06216.1 - 9.7e-107 356.7 0.4 9.7e-107 356.7 0.4 2.9 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EEA06216.1 - 1.8e-23 83.1 0.1 1.8e-23 83.1 0.1 3.8 3 1 1 4 4 4 1 Microtubule binding Rab_bind PF16704.5 EEA06216.1 - 0.19 11.8 10.6 0.7 10.0 4.2 3.9 3 0 0 3 3 3 0 Rab binding domain Tropomyosin PF00261.20 EEA06216.1 - 0.29 10.5 38.1 0.13 11.7 15.1 3.3 4 0 0 4 4 4 0 Tropomyosin DUF948 PF06103.11 EEA06216.1 - 2.7 8.3 16.1 40 4.6 5.6 4.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DnaJ-X PF14308.6 EEA06217.1 - 0.27 10.6 3.2 0.49 9.8 3.2 1.3 1 0 0 1 1 1 0 X-domain of DnaJ-containing NOA36 PF06524.12 EEA06217.1 - 0.5 9.6 8.3 0.81 9.0 8.3 1.2 1 0 0 1 1 1 0 NOA36 protein RCC1 PF00415.18 EEA06218.1 - 1.5e-80 265.7 15.3 3.7e-15 56.3 0.1 7.1 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA06218.1 - 3.1e-40 135.2 42.4 1.7e-08 34.0 0.3 8.3 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EEA06218.1 - 0.00032 20.9 2.2 0.21 11.8 0.0 3.9 4 1 1 5 5 5 2 Putative heavy-metal chelation Hira PF07569.11 EEA06218.1 - 0.16 11.7 2.3 34 4.1 0.0 3.9 4 1 0 4 4 4 0 TUP1-like enhancer of split OTU PF02338.19 EEA06219.1 - 2.2e-15 57.3 0.4 1.3e-14 54.8 0.1 2.4 2 1 0 2 2 2 1 OTU-like cysteine protease RRM_1 PF00076.22 EEA06220.1 - 5.7e-17 61.3 0.0 9.1e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 EEA06220.1 - 0.049 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif 2 FAM176 PF14851.6 EEA06221.1 - 0.023 14.3 1.9 0.035 13.8 1.9 1.3 1 0 0 1 1 1 0 FAM176 family NESP55 PF06390.12 EEA06221.1 - 0.17 11.4 4.7 0.23 11.0 4.7 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) YqzM PF14141.6 EEA06221.1 - 0.26 11.3 0.1 0.26 11.3 0.1 2.0 2 0 0 2 2 2 0 YqzM-like protein Nucleoside_tran PF01733.18 EEA06221.1 - 8.7 5.6 6.4 18 4.6 2.6 2.6 2 1 1 3 3 3 0 Nucleoside transporter IFT43 PF15305.6 EEA06222.1 - 0.044 14.0 4.1 0.074 13.2 4.1 1.3 1 0 0 1 1 1 0 Intraflagellar transport protein 43 TPX2_importin PF12214.8 EEA06223.1 - 0.0023 18.1 11.9 0.016 15.4 0.6 3.6 2 2 1 3 3 3 3 Cell cycle regulated microtubule associated protein NTP_transf_2 PF01909.23 EEA06224.1 - 0.0074 16.6 0.0 0.026 14.8 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF4269 PF14091.6 EEA06224.1 - 0.091 13.0 0.1 0.4 10.9 0.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4269) FKBP_C PF00254.28 EEA06225.1 - 6.2e-22 77.7 0.0 1.1e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 EEA06225.1 - 2.8e-08 34.6 0.1 7.2e-08 33.3 0.1 1.7 1 1 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Helicase_C_2 PF13307.6 EEA06228.1 - 5.2e-52 176.5 0.0 1.2e-51 175.3 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EEA06228.1 - 5.4e-40 136.9 11.7 1.3e-39 135.6 5.0 3.3 2 1 0 2 2 2 1 DEAD_2 ResIII PF04851.15 EEA06228.1 - 3.3e-06 27.2 3.9 0.00052 20.1 0.0 3.5 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA06228.1 - 2.4e-05 24.2 0.6 0.25 11.1 0.0 3.7 4 0 0 4 4 4 2 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA06228.1 - 0.0031 17.8 0.6 1.7 8.9 0.0 3.1 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EEA06228.1 - 0.11 12.0 0.2 19 4.6 0.1 2.5 2 0 0 2 2 2 0 PhoH-like protein Exog_C PF18026.1 EEA06228.1 - 0.13 12.4 0.2 0.52 10.4 0.1 2.2 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain DnaJ PF00226.31 EEA06229.1 - 9e-29 99.4 1.0 1.8e-28 98.5 1.0 1.5 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EEA06229.1 - 0.038 13.9 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein Motile_Sperm PF00635.26 EEA06232.1 - 1e-25 89.7 0.0 3.4e-25 88.0 0.0 1.8 2 0 0 2 2 2 1 MSP (Major sperm protein) domain SDH_alpha PF03313.15 EEA06232.1 - 0.029 14.1 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Serine dehydratase alpha chain Rad10 PF03834.14 EEA06233.1 - 4.4e-36 123.4 1.2 4.4e-36 123.4 1.2 1.7 2 0 0 2 2 2 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 PF12826.7 EEA06233.1 - 0.00013 22.0 0.0 0.00039 20.5 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif PND PF17949.1 EEA06233.1 - 0.0043 17.3 0.5 0.0081 16.4 0.2 1.6 2 0 0 2 2 2 1 FANCM pseudonuclease domain HHH_5 PF14520.6 EEA06233.1 - 0.0065 17.1 0.0 0.014 16.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain hnRNP_Q_AcD PF18360.1 EEA06233.1 - 0.015 15.2 0.1 0.13 12.3 0.0 2.4 3 0 0 3 3 3 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain HHH PF00633.23 EEA06233.1 - 0.048 13.5 0.0 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif AP2 PF00847.20 EEA06234.1 - 0.42 10.9 9.0 0.11 12.8 0.5 2.6 2 0 0 2 2 2 0 AP2 domain MOZ_SAS PF01853.18 EEA06235.1 - 1e-73 246.8 0.0 1.8e-73 246.0 0.0 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EEA06235.1 - 7e-21 73.6 1.1 2.8e-20 71.7 0.5 2.4 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 EEA06235.1 - 9.2e-11 41.5 0.2 2.2e-10 40.2 0.2 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.25 EEA06235.1 - 6.1e-05 23.2 0.4 0.053 13.8 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA06235.1 - 0.0037 17.6 0.0 0.011 16.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MORN PF02493.20 EEA06237.1 - 2.8e-88 284.8 96.6 1.8e-08 33.8 1.9 14.9 15 0 0 15 15 15 14 MORN repeat DUF2158 PF09926.9 EEA06237.1 - 0.014 15.1 4.7 32 4.3 0.0 5.5 3 2 2 6 6 6 0 Uncharacterized small protein (DUF2158) TAA-Trp-ring PF15401.6 EEA06237.1 - 2.3 8.7 4.7 0.64 10.5 0.4 2.3 2 1 1 3 3 3 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin PA_decarbox PF05870.11 EEA06237.1 - 5.6 6.6 9.0 2.4 7.8 1.4 2.8 1 1 0 2 2 2 0 Phenolic acid decarboxylase (PAD) Rieske_3 PF18465.1 EEA06238.1 - 0.076 13.3 0.7 0.33 11.2 0.7 2.1 1 0 0 1 1 1 0 Rieske 3Fe-4S LUC7 PF03194.15 EEA06239.1 - 1.3e-56 192.1 6.9 2e-56 191.5 6.9 1.3 1 0 0 1 1 1 1 LUC7 N_terminus Baculo_IE-1 PF05290.11 EEA06239.1 - 1.6 8.7 5.6 24 4.9 0.1 2.9 1 1 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) IPPT PF01715.17 EEA06240.1 - 7.9e-53 179.6 0.5 1e-52 179.2 0.5 1.1 1 0 0 1 1 1 1 IPP transferase KTI12 PF08433.10 EEA06240.1 - 0.0021 17.6 0.2 0.13 11.6 0.0 2.2 2 0 0 2 2 2 2 Chromatin associated protein KTI12 IPT PF01745.16 EEA06240.1 - 0.077 12.4 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 Isopentenyl transferase Rpr2 PF04032.16 EEA06241.1 - 5.7e-07 29.7 2.9 5.7e-07 29.7 2.9 2.1 1 1 1 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ribosomal_L40e PF01020.17 EEA06241.1 - 0.58 10.1 0.1 0.58 10.1 0.1 3.8 3 0 0 3 3 3 0 Ribosomal L40e family Tnp_22_trimer PF17489.2 EEA06241.1 - 2.2 8.3 8.9 1.6 8.8 0.7 3.5 3 1 0 3 3 3 0 L1 transposable element trimerization domain PPTA PF01239.22 EEA06243.1 - 1.7e-28 97.5 25.9 2.8e-07 30.1 0.4 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat SID-1_RNA_chan PF13965.6 EEA06244.1 - 7.5e-05 21.3 3.7 9.4e-05 21.0 3.7 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 EEA06244.1 - 0.003 17.7 0.7 0.0038 17.3 0.7 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region MMM1 PF10296.9 EEA06244.1 - 0.0045 16.1 0.9 0.0059 15.7 0.9 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 SKN1 PF03935.15 EEA06244.1 - 0.011 14.2 0.1 0.012 14.1 0.1 1.2 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) LapA_dom PF06305.11 EEA06244.1 - 0.03 14.1 0.1 0.066 13.0 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain OATP PF03137.20 EEA06244.1 - 0.035 12.4 0.3 0.039 12.3 0.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CSG2 PF16965.5 EEA06244.1 - 0.037 13.0 1.7 0.046 12.7 1.7 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 EEA06244.1 - 0.049 13.4 2.4 0.069 12.9 2.4 1.5 1 1 0 1 1 1 0 Connexin IKKbetaNEMObind PF12179.8 EEA06244.1 - 0.061 13.4 0.8 0.16 12.0 0.8 1.8 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain Chordopox_G3 PF06129.12 EEA06244.1 - 0.076 13.7 1.8 0.15 12.8 0.2 1.9 1 1 1 2 2 2 0 Chordopoxvirus G3 protein Cytochrom_C_asm PF01578.20 EEA06244.1 - 0.15 11.8 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 Cytochrome C assembly protein WBP-1 PF11669.8 EEA06244.1 - 0.18 12.4 1.1 0.39 11.4 0.7 1.7 1 1 1 2 2 2 0 WW domain-binding protein 1 CLN3 PF02487.17 EEA06244.1 - 0.22 10.5 0.4 0.24 10.4 0.4 1.2 1 0 0 1 1 1 0 CLN3 protein Ctr PF04145.15 EEA06244.1 - 0.51 11.0 2.8 0.74 10.4 2.8 1.4 1 1 0 1 1 1 0 Ctr copper transporter family FAM176 PF14851.6 EEA06244.1 - 0.52 10.0 2.4 0.96 9.1 2.4 1.6 1 1 0 1 1 1 0 FAM176 family DUF4834 PF16118.5 EEA06244.1 - 0.91 10.5 5.6 3.3 8.7 5.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) YMF19 PF02326.15 EEA06244.1 - 1.1 10.0 5.6 2.5 8.9 3.1 2.2 1 1 1 2 2 2 0 Plant ATP synthase F0 HCO3_cotransp PF00955.21 EEA06244.1 - 1.2 7.9 3.2 1.5 7.5 3.2 1.1 1 0 0 1 1 1 0 HCO3- transporter family OAD_gamma PF04277.13 EEA06244.1 - 1.3 9.6 6.7 0.13 12.8 2.0 1.9 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain S1FA PF04689.13 EEA06244.1 - 2.8 8.1 8.0 0.11 12.7 1.0 2.1 2 1 0 2 2 2 0 DNA binding protein S1FA Gti1_Pac2 PF09729.9 EEA06244.1 - 5 7.2 11.0 8.2 6.5 11.0 1.5 1 1 0 1 1 1 0 Gti1/Pac2 family DUF1387 PF07139.11 EEA06244.1 - 6.4 6.4 16.6 8.8 6.0 16.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Tubulin_3 PF14881.6 EEA06245.1 - 0.13 11.9 2.8 0.61 9.7 0.7 3.0 2 0 0 2 2 2 0 Tubulin domain DUF4298 PF14131.6 EEA06245.1 - 0.25 11.3 4.9 12 6.0 0.1 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) MCPsignal PF00015.21 EEA06245.1 - 1.4 8.7 7.0 0.28 11.0 0.7 3.0 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain HECT PF00632.25 EEA06246.1 - 8.9e-88 294.7 0.2 1.7e-87 293.8 0.2 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) NOT2_3_5 PF04153.18 EEA06247.1 - 5.3e-19 68.6 3.1 5.3e-19 68.6 3.1 1.6 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Evr1_Alr PF04777.13 EEA06248.1 - 3.9e-15 56.2 0.1 9.8e-15 54.9 0.1 1.7 1 0 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 EEA06248.1 - 4e-07 30.0 0.1 9.7e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EEA06248.1 - 0.015 15.1 0.7 0.025 14.4 0.7 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain TraF PF13728.6 EEA06248.1 - 0.035 13.9 0.1 0.077 12.8 0.1 1.5 1 1 0 1 1 1 0 F plasmid transfer operon protein AhpC-TSA PF00578.21 EEA06248.1 - 0.041 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_2 PF13098.6 EEA06248.1 - 0.046 14.2 0.1 0.12 12.8 0.1 1.7 1 0 0 1 1 1 0 Thioredoxin-like domain eIF-5_eIF-2B PF01873.17 EEA06248.1 - 0.2 11.6 2.1 0.37 10.7 0.1 2.4 3 0 0 3 3 3 0 Domain found in IF2B/IF5 Redoxin PF08534.10 EEA06248.1 - 0.41 10.3 1.8 0.48 10.1 0.0 2.0 3 0 0 3 3 3 0 Redoxin DUF35_N PF12172.8 EEA06248.1 - 1.4 8.9 6.0 0.35 10.8 0.9 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Alba PF01918.21 EEA06249.1 - 4.8e-13 48.7 0.1 1e-12 47.6 0.1 1.6 1 0 0 1 1 1 1 Alba SicP-binding PF09119.10 EEA06249.1 - 0.1 12.6 0.1 7.3 6.6 0.0 2.7 2 2 1 4 4 4 0 SicP binding Ribosomal_L21e PF01157.18 EEA06250.1 - 4.7e-44 148.4 2.5 5.8e-44 148.1 2.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L21e RNA_replicase_B PF03431.13 EEA06250.1 - 0.016 13.7 0.0 0.018 13.5 0.0 1.1 1 0 0 1 1 1 0 RNA replicase, beta-chain DUF1103 PF06513.11 EEA06250.1 - 0.049 13.2 0.2 0.064 12.9 0.2 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Phosphorylase PF00343.20 EEA06251.1 - 1.8e-300 998.4 0.1 2.3e-300 998.0 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase NAC PF01849.18 EEA06253.1 - 2.8e-14 52.8 0.0 4.6e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 NAC domain DUF2462 PF09495.10 EEA06254.1 - 0.00011 22.9 5.0 0.00015 22.4 5.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) SRR1 PF07985.12 EEA06255.1 - 4.2e-10 39.5 0.1 7.7e-10 38.7 0.1 1.4 1 0 0 1 1 1 1 SRR1 CutA1 PF03091.15 EEA06256.1 - 7.9e-35 118.7 1.2 1e-34 118.4 1.2 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Ins145_P3_rec PF08709.11 EEA06256.1 - 0.087 12.0 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor PHF5 PF03660.14 EEA06257.1 - 1.1e-50 170.1 14.3 1.3e-50 170.0 14.3 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EEA06257.1 - 0.43 8.4 9.4 0.42 8.4 9.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EEA06257.1 - 0.46 10.5 15.0 2.3 8.3 12.8 2.7 1 1 1 2 2 2 0 Double zinc ribbon Topoisom_bac PF01131.20 EEA06258.1 - 4.6e-105 352.0 0.0 5.7e-105 351.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EEA06258.1 - 6.4e-17 61.7 0.0 2e-16 60.1 0.0 1.9 2 0 0 2 2 2 1 Toprim domain DUF86 PF01934.17 EEA06258.1 - 0.0019 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF86 Cript PF10235.9 EEA06258.1 - 0.2 12.3 4.2 0.27 11.8 0.1 2.9 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT DZR PF12773.7 EEA06258.1 - 1.3 9.1 18.1 17 5.5 4.6 4.1 2 1 1 3 3 3 0 Double zinc ribbon mRNA_cap_enzyme PF01331.19 EEA06259.1 - 2.7e-36 125.2 0.6 3.5e-23 82.4 0.2 2.2 1 1 1 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EEA06259.1 - 5.9e-13 49.4 0.0 1.7e-12 47.9 0.0 1.9 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain Sec1 PF00995.23 EEA06260.1 - 1.1e-84 285.8 5.0 1.3e-84 285.5 5.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF4322 PF14210.6 EEA06260.1 - 0.0043 16.9 0.0 0.016 15.1 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4322) Herpes_IE1 PF07340.11 EEA06260.1 - 0.064 12.2 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Mito_carr PF00153.27 EEA06261.1 - 9.5e-08 31.9 0.0 0.00024 21.0 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein Mito_carr PF00153.27 EEA06262.1 - 3.4e-35 119.8 4.0 2.9e-15 56.0 0.4 3.9 2 2 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA06262.1 - 0.00043 19.5 0.1 0.092 11.9 0.0 2.9 2 1 1 3 3 3 2 Gammaproteobacterial serine protease MFS_1 PF07690.16 EEA06263.1 - 0.043 12.7 52.6 0.053 12.4 29.9 3.6 2 1 0 3 3 3 0 Major Facilitator Superfamily WD40 PF00400.32 EEA06265.1 - 1.1e-06 29.2 3.2 0.13 13.2 0.0 4.3 3 0 0 3 3 3 2 WD domain, G-beta repeat zf-HC5HC2H PF13771.6 EEA06265.1 - 2.4e-05 24.5 3.9 2.4e-05 24.5 3.9 2.7 2 0 0 2 2 2 1 PHD-like zinc-binding domain Bromodomain PF00439.25 EEA06265.1 - 7.1e-05 22.8 0.1 0.00037 20.5 0.1 2.3 1 0 0 1 1 1 1 Bromodomain zf-HC5HC2H_2 PF13832.6 EEA06265.1 - 0.0002 21.5 5.3 0.00052 20.2 3.7 2.5 1 1 1 2 2 2 1 PHD-zinc-finger like domain Med27 PF11571.8 EEA06265.1 - 0.0012 19.1 0.4 1.1 9.7 0.0 3.4 2 0 0 2 2 2 2 Mediator complex subunit 27 DUF5046 PF16465.5 EEA06265.1 - 0.014 14.9 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5046) zf-RING-like PF08746.11 EEA06265.1 - 0.48 10.8 4.5 2.1 8.7 4.5 2.2 1 0 0 1 1 1 0 RING-like domain PAN_4 PF14295.6 EEA06266.1 - 0.057 13.3 0.9 0.057 13.3 0.9 1.8 2 0 0 2 2 2 0 PAN domain PC_rep PF01851.22 EEA06267.1 - 0.0063 16.9 5.4 0.066 13.7 0.2 3.5 3 0 0 3 3 3 2 Proteasome/cyclosome repeat Exo_endo_phos PF03372.23 EEA06268.1 - 5.6e-07 29.3 0.0 1.7e-06 27.7 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PIG-X PF08320.12 EEA06269.1 - 8e-11 42.3 0.7 5.5e-10 39.5 0.6 2.4 2 1 0 2 2 2 1 PIG-X / PBN1 DEAD PF00270.29 EEA06271.1 - 2.4e-46 157.7 0.0 1.2e-45 155.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06271.1 - 8.4e-20 71.2 4.5 1.5e-19 70.4 0.2 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA06271.1 - 1.8e-12 47.3 0.1 4.9e-12 45.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Myb_DNA-binding PF00249.31 EEA06272.1 - 6.4e-26 90.3 3.8 1.3e-13 50.9 0.3 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA06272.1 - 2.5e-21 75.7 2.1 7.7e-16 58.1 0.1 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA06272.1 - 0.032 14.1 0.1 9 6.3 0.0 2.8 2 1 0 2 2 2 0 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 EEA06272.1 - 0.041 14.3 2.8 0.14 12.6 0.1 2.9 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain SLIDE PF09111.10 EEA06272.1 - 0.11 12.5 2.1 4.6 7.3 0.0 3.7 3 1 1 4 4 4 0 SLIDE Myb_DNA-bind_5 PF13873.6 EEA06272.1 - 0.61 10.2 3.9 5.4 7.2 0.3 3.4 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain PHD PF00628.29 EEA06273.1 - 0.00018 21.3 4.4 0.00018 21.3 4.4 2.4 1 1 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EEA06273.1 - 3.4 7.8 9.9 1.6 8.9 5.9 2.7 2 1 0 2 2 2 0 PHD-finger Diphthamide_syn PF01866.17 EEA06274.1 - 4.9e-87 292.2 0.4 6.7e-87 291.8 0.4 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein DUF3273 PF11677.8 EEA06275.1 - 3.7e-66 223.2 13.0 4.7e-66 222.8 13.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) DUF3273 PF11677.8 EEA06276.1 - 3.4e-88 295.4 8.8 3.8e-88 295.2 8.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) COX14 PF14880.6 EEA06276.1 - 0.29 11.0 0.1 0.29 11.0 0.1 3.2 4 0 0 4 4 4 0 Cytochrome oxidase c assembly DUF3810 PF12725.7 EEA06276.1 - 0.47 9.8 5.1 9.5 5.5 5.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) DUF4834 PF16118.5 EEA06276.1 - 3.7 8.6 5.4 32 5.6 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) LRR_4 PF12799.7 EEA06277.1 - 2.8e-05 24.4 30.9 0.14 12.6 0.3 6.8 5 1 0 6 6 6 4 Leucine Rich repeats (2 copies) SWIB PF02201.18 EEA06277.1 - 0.05 13.5 1.2 0.25 11.3 0.1 2.5 2 0 0 2 2 2 0 SWIB/MDM2 domain LRR_6 PF13516.6 EEA06277.1 - 0.13 12.3 15.7 7.1 7.0 0.1 6.8 7 0 0 7 7 7 0 Leucine Rich repeat F-box PF00646.33 EEA06277.1 - 0.16 11.9 3.7 0.51 10.3 0.0 3.5 4 0 0 4 4 4 0 F-box domain LRR_1 PF00560.33 EEA06277.1 - 2.7 8.9 0.0 2.7 8.9 0.0 8.7 9 1 0 9 9 9 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 EEA06278.1 - 2.3e-51 174.5 3.1 2.3e-51 174.5 3.1 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GTP_EFTU PF00009.27 EEA06279.1 - 2.6e-32 112.0 0.1 3.7e-31 108.2 0.0 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 EEA06279.1 - 5.5e-17 61.5 0.0 1.7e-16 59.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 IF-2 PF11987.8 EEA06279.1 - 7.6e-17 61.4 3.0 1.1e-16 60.8 0.1 2.8 2 1 1 3 3 3 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EEA06279.1 - 5e-16 58.8 1.3 1.1e-10 41.8 0.1 2.9 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA06279.1 - 3e-06 27.3 1.3 4.5e-05 23.5 0.0 3.4 3 1 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EEA06279.1 - 0.0007 19.8 0.0 0.0022 18.2 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EEA06279.1 - 0.077 12.8 0.0 0.3 10.9 0.0 2.1 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein RR_TM4-6 PF06459.12 EEA06279.1 - 5.9 6.6 20.0 12 5.6 20.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L5_C PF00673.21 EEA06280.1 - 4.6e-22 78.0 0.0 7.9e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EEA06280.1 - 2e-19 69.6 0.3 3.5e-19 68.9 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 RRM_1 PF00076.22 EEA06281.1 - 2.2e-10 40.2 0.3 6.9e-07 29.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 EEA06281.1 - 0.00024 21.0 0.9 0.0016 18.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) RRM_5 PF13893.6 EEA06281.1 - 0.00052 19.6 0.0 0.001 18.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA06281.1 - 0.0015 18.4 0.9 0.0029 17.4 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif DUF1866 PF08952.11 EEA06281.1 - 0.0027 17.6 0.0 0.0048 16.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) CbiD PF01888.17 EEA06281.1 - 0.012 15.0 0.2 0.017 14.5 0.2 1.2 1 0 0 1 1 1 0 CbiD Nup35_RRM_2 PF14605.6 EEA06281.1 - 0.031 14.3 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Androgen_recep PF02166.16 EEA06281.1 - 0.083 11.7 8.2 0.11 11.3 8.2 1.1 1 0 0 1 1 1 0 Androgen receptor CAP_N PF01213.19 EEA06281.1 - 0.36 10.3 5.7 0.62 9.5 5.7 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EEA06281.1 - 1.8 8.6 11.7 6.6 6.8 11.6 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 NT-C2 PF10358.9 EEA06282.1 - 0.0045 16.7 1.1 0.037 13.8 1.1 2.2 1 1 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Ion_trans_2 PF07885.16 EEA06283.1 - 7.6e-13 48.2 1.1 7.6e-13 48.2 1.1 2.6 3 0 0 3 3 3 1 Ion channel BK_channel_a PF03493.18 EEA06283.1 - 5.3e-08 33.0 0.0 1.5e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Methyltrans_RNA PF04452.14 EEA06284.1 - 2e-35 122.2 0.0 1.7e-31 109.3 0.0 2.1 2 0 0 2 2 2 2 RNA methyltransferase CDC37_M PF08565.11 EEA06286.1 - 0.03 14.2 2.6 0.33 10.9 0.1 3.3 2 0 0 2 2 2 0 Cdc37 Hsp90 binding domain Vault_3 PF17795.1 EEA06286.1 - 0.14 12.2 0.0 13 5.9 0.0 3.1 3 0 0 3 3 3 0 Major Vault Protein Repeat domain cEGF PF12662.7 EEA06287.1 - 2.5e-05 24.1 197.3 0.75 9.8 0.3 34.2 35 3 1 36 36 36 20 Complement Clr-like EGF-like SARG PF15385.6 EEA06287.1 - 2.8 7.1 8.1 4.9 6.3 4.1 2.1 2 0 0 2 2 2 0 Specifically androgen-regulated gene protein Abhydrolase_4 PF08386.10 EEA06287.1 - 8.3 6.6 10.3 3.4 7.9 0.1 4.7 5 0 0 5 5 5 0 TAP-like protein XRN_N PF03159.18 EEA06290.1 - 1.9e-89 299.3 0.0 4.6e-89 298.0 0.0 1.7 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EEA06290.1 - 5.9e-53 180.4 19.4 4.3e-27 95.2 0.0 4.2 4 1 0 4 4 4 3 Xrn1 helical domain SH3_12 PF18129.1 EEA06290.1 - 7.6e-19 67.6 0.2 6.8e-18 64.5 0.4 2.3 2 0 0 2 2 2 1 Xrn1 SH3-like domain DUF4344 PF14247.6 EEA06290.1 - 0.00023 20.9 0.2 0.00045 20.0 0.2 1.5 1 0 0 1 1 1 1 Putative metallopeptidase XRN1_D1 PF18332.1 EEA06290.1 - 0.00061 19.6 1.1 0.0026 17.6 0.0 2.3 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain DUF4860 PF16152.5 EEA06290.1 - 0.038 13.8 1.2 2.4 8.1 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4860) Adaptin_N PF01602.20 EEA06291.1 - 5.2e-30 104.5 19.6 3.7e-17 62.1 0.6 4.1 3 1 0 3 3 3 3 Adaptin N terminal region Not1 PF04054.15 EEA06292.1 - 6e-112 374.2 5.4 3.2e-61 207.3 0.7 2.6 1 1 1 2 2 2 2 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EEA06292.1 - 1.8e-53 181.3 1.1 6.2e-37 127.2 0.1 2.5 2 0 0 2 2 2 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EEA06292.1 - 2.5e-47 160.5 0.0 6.2e-47 159.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EEA06292.1 - 2.2e-36 124.8 0.1 7.3e-36 123.1 0.1 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain Nab6_mRNP_bdg PF10567.9 EEA06292.1 - 0.093 12.2 0.0 0.093 12.2 0.0 3.1 5 0 0 5 5 5 0 RNA-recognition motif AMPK1_CBM PF16561.5 EEA06293.1 - 7.4e-25 87.0 1.2 4.5e-24 84.5 0.3 2.2 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase DUF3048_C PF17479.2 EEA06293.1 - 0.017 15.5 1.3 1.7 9.1 1.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain CBM_48 PF02922.18 EEA06293.1 - 0.062 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) STT3 PF02516.14 EEA06294.1 - 2.9e-80 270.6 38.9 2.1e-79 267.7 38.9 2.0 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Cadherin_C_2 PF16492.5 EEA06294.1 - 1.2 10.0 5.8 0.2 12.4 0.7 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal BT1 PF03092.16 EEA06295.1 - 1.3e-60 205.1 19.0 2.6e-35 121.7 11.4 2.1 2 0 0 2 2 2 2 BT1 family MFS_1 PF07690.16 EEA06295.1 - 1.5e-13 50.4 26.6 1.5e-13 50.4 26.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily PUCC PF03209.15 EEA06295.1 - 0.0018 17.4 0.7 0.0018 17.4 0.7 3.8 2 2 1 3 3 3 2 PUCC protein MFS_1_like PF12832.7 EEA06295.1 - 0.013 14.4 14.3 0.0078 15.1 12.1 1.9 1 1 0 1 1 1 0 MFS_1 like family Spidroin_N PF16763.5 EEA06295.1 - 0.12 12.4 0.2 0.22 11.6 0.2 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term Methyltransf_10 PF05971.12 EEA06296.1 - 1.1e-60 205.5 2.2 4.2e-41 141.2 0.2 2.9 2 1 0 2 2 2 2 RNA methyltransferase Methyltransf_31 PF13847.6 EEA06296.1 - 0.024 14.4 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EEA06296.1 - 0.028 15.1 0.0 0.06 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EEA06296.1 - 0.058 13.2 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RAD51_interact PF15696.5 EEA06296.1 - 0.13 12.4 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 RAD51 interacting motif UPF0122 PF04297.14 EEA06297.1 - 0.067 13.4 2.8 0.28 11.4 0.1 3.4 3 0 0 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like DUF5446 PF17522.2 EEA06297.1 - 0.16 12.2 0.9 0.48 10.6 0.9 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5446) YjeF_N PF03853.15 EEA06301.1 - 1.9e-26 92.9 0.0 2.4e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Glycos_transf_2 PF00535.26 EEA06302.1 - 4.4e-21 75.4 0.0 8.8e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EEA06302.1 - 6.3e-07 29.5 0.0 1e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Ricin_B_lectin PF00652.22 EEA06302.1 - 0.00014 22.1 1.2 0.0037 17.5 0.0 2.8 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EEA06302.1 - 0.006 16.2 0.8 0.019 14.6 0.8 1.8 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Ribonuc_red_lgC PF02867.15 EEA06303.1 - 3.5e-190 633.0 0.0 5e-190 632.5 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EEA06303.1 - 9.9e-22 76.7 0.0 2.3e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EEA06303.1 - 6.3e-13 49.1 0.0 2.1e-12 47.4 0.0 2.0 2 0 0 2 2 2 1 ATP cone domain ORC3_N PF07034.11 EEA06304.1 - 1.5e-08 34.1 0.0 1.5e-08 34.1 0.0 2.2 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EEA06304.1 - 1.1e-06 28.7 0.0 3.3e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal APG6_N PF17675.1 EEA06305.1 - 0.15 12.6 25.1 0.28 11.7 23.1 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Phage_lysis PF03245.13 EEA06305.1 - 1.8 8.7 6.3 1.2 9.3 4.0 1.9 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Seryl_tRNA_N PF02403.22 EEA06305.1 - 6.2 7.1 18.6 1.9 8.8 11.7 2.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Kinesin PF00225.23 EEA06306.1 - 1.6e-95 319.9 3.7 1.6e-95 319.9 3.7 2.8 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EEA06306.1 - 5.5e-26 91.3 0.0 5.5e-26 91.3 0.0 3.3 3 0 0 3 3 3 1 Microtubule binding HIP1_clath_bdg PF16515.5 EEA06306.1 - 0.016 15.8 8.5 0.016 15.8 8.5 5.6 4 2 0 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Vac_Fusion PF02346.16 EEA06306.1 - 0.34 10.6 3.5 19 5.0 0.7 4.1 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Inhibitor_I42 PF09394.10 EEA06307.1 - 1.8e-17 63.5 0.0 3.5e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 Endotoxin_N PF03945.14 EEA06307.1 - 0.033 13.9 1.6 0.041 13.6 1.6 1.2 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain Kinesin PF00225.23 EEA06308.1 - 1.1e-64 218.5 0.1 1.1e-64 218.5 0.1 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA06308.1 - 4.2e-18 65.7 0.0 9.7e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF1764 PF08576.10 EEA06309.1 - 6e-23 81.6 0.7 8.9e-23 81.1 0.7 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Filament PF00038.21 EEA06309.1 - 0.00077 19.1 1.1 0.00095 18.8 1.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Transposase_22 PF02994.14 EEA06309.1 - 0.049 13.8 2.7 0.064 13.4 2.7 1.2 1 0 0 1 1 1 0 L1 transposable element RBD-like domain UPF0137 PF03677.13 EEA06309.1 - 0.056 13.2 1.9 0.07 12.9 1.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Cortex-I_coil PF09304.10 EEA06309.1 - 0.059 13.6 1.5 0.093 13.0 1.4 1.5 1 1 0 1 1 1 0 Cortexillin I, coiled coil BCIP PF13862.6 EEA06310.1 - 4.4e-37 127.9 0.3 6.3e-37 127.4 0.3 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein SRP19 PF01922.17 EEA06311.1 - 4.2e-23 82.1 0.0 5.6e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 SRP19 protein ANAPC10 PF03256.16 EEA06312.1 - 1.9e-59 200.5 0.0 2.4e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 EEA06312.1 - 0.0014 18.8 0.0 0.0021 18.2 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain DUF21 PF01595.20 EEA06313.1 - 2.6e-34 118.5 1.2 4.2e-34 117.8 1.2 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain D123 PF07065.14 EEA06314.1 - 2.8e-29 102.2 7.7 1e-28 100.4 5.5 2.1 1 1 1 2 2 2 2 D123 Ribosomal_L28e PF01778.17 EEA06315.1 - 7.3e-32 110.5 0.4 7.3e-32 110.5 0.4 1.7 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EEA06315.1 - 2.4e-18 66.5 10.9 5.2e-18 65.5 10.6 1.7 1 1 0 1 1 1 1 Mak16 protein C-terminal region Cbl_N3 PF02762.14 EEA06315.1 - 0.13 12.2 0.0 0.38 10.6 0.0 1.8 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Acetyltransf_1 PF00583.25 EEA06317.1 - 9.9e-06 25.8 0.0 1.9e-05 24.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA06317.1 - 0.00089 19.6 0.1 0.0016 18.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA06317.1 - 0.028 14.3 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HEAT_2 PF13646.6 EEA06318.1 - 0.0058 17.0 0.0 0.28 11.6 0.0 2.4 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 EEA06318.1 - 0.02 15.1 0.1 18 5.9 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat DUF996 PF06195.13 EEA06318.1 - 0.53 10.6 2.9 6.5 7.0 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF996) DEAD PF00270.29 EEA06319.1 - 2.4e-23 82.8 0.0 5e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06319.1 - 2.4e-19 69.7 0.0 8.8e-19 67.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06319.1 - 0.00034 20.7 0.0 0.0053 16.8 0.0 2.7 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EEA06319.1 - 0.025 14.9 0.2 0.27 11.5 0.2 2.3 1 1 0 1 1 1 0 AAA domain Metallothio_11 PF02066.15 EEA06319.1 - 1.2 9.3 6.1 1.4 9.2 3.1 2.7 3 0 0 3 3 3 0 Metallothionein family 11 Rtf2 PF04641.12 EEA06320.1 - 1.6e-07 31.0 0.2 1e-05 25.1 0.0 2.1 2 0 0 2 2 2 2 Rtf2 RING-finger zf-NOSIP PF15906.5 EEA06320.1 - 1.4e-05 25.1 0.4 5.5e-05 23.2 0.1 2.0 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 EEA06320.1 - 0.00066 19.8 0.0 0.011 15.9 0.0 2.3 2 1 0 2 2 2 1 U-box domain zf-Nse PF11789.8 EEA06320.1 - 0.0014 18.4 0.2 0.065 13.1 0.4 2.4 1 1 1 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit DUF3546 PF12066.8 EEA06321.1 - 2.2e-21 76.1 2.4 2.2e-21 76.1 2.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 EEA06321.1 - 1e-09 39.1 1.7 1.5e-09 38.5 0.4 1.8 2 0 0 2 2 2 1 Arsenite-resistance protein 2 PI3_PI4_kinase PF00454.27 EEA06322.1 - 9e-34 117.4 3.3 4.5e-31 108.6 0.3 3.1 2 2 1 3 3 3 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EEA06322.1 - 6.2e-20 71.4 2.5 1.8e-19 69.8 2.5 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Linker_histone PF00538.19 EEA06322.1 - 0.19 12.1 0.2 0.53 10.7 0.2 1.7 1 0 0 1 1 1 0 linker histone H1 and H5 family Prenyltrans PF00432.21 EEA06323.1 - 2.2e-51 171.2 11.3 2.1e-11 43.4 0.4 6.2 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EEA06323.1 - 0.0005 19.2 0.0 0.61 9.1 0.0 2.6 1 1 2 3 3 3 2 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 EEA06323.1 - 0.029 13.4 0.2 1.2 8.1 0.0 2.9 2 1 2 4 4 4 0 A-macroglobulin TED domain Ribosomal_S5 PF00333.20 EEA06323.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain Hexose_dehydrat PF03559.14 EEA06323.1 - 0.21 11.0 0.0 0.42 10.0 0.0 1.4 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase PI3_PI4_kinase PF00454.27 EEA06324.1 - 9.2e-17 61.7 0.0 7.6e-16 58.7 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EEA06324.1 - 2.5e-13 50.0 1.6 1.4e-09 37.7 0.1 2.8 3 0 0 3 3 3 2 FAT domain FATC PF02260.20 EEA06324.1 - 0.087 12.7 0.1 0.29 11.0 0.1 1.9 1 0 0 1 1 1 0 FATC domain DUF765 PF05570.11 EEA06324.1 - 3.5 7.9 5.4 1.1 9.4 0.1 3.0 2 0 0 2 2 2 0 Circovirus protein of unknown function (DUF765) Torus PF16131.5 EEA06325.1 - 7.5e-06 26.6 7.8 0.00092 19.9 0.2 2.4 1 1 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EEA06325.1 - 8.6e-05 22.5 3.0 8.6e-05 22.5 3.0 4.1 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH PF00642.24 EEA06325.1 - 0.00022 21.1 19.9 0.00025 20.8 2.7 4.3 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EEA06325.1 - 0.001 18.8 19.8 0.003 17.3 1.2 3.7 4 0 0 4 4 4 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EEA06325.1 - 0.93 9.7 11.8 6 7.1 4.7 2.7 1 1 1 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 EEA06325.1 - 2.4 8.7 22.4 0.89 10.1 2.6 3.7 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger Stk19 PF10494.9 EEA06326.1 - 0.16 11.6 5.4 0.48 10.1 5.4 2.0 1 1 0 1 1 1 0 Serine-threonine protein kinase 19 Mcm10 PF09332.11 EEA06327.1 - 5.3e-12 45.8 9.9 5.3e-12 45.8 9.9 1.7 2 0 0 2 2 2 1 Mcm10 replication factor zf-primase PF09329.11 EEA06327.1 - 6.8e-09 35.4 0.1 6.8e-09 35.4 0.1 2.1 2 0 0 2 2 2 1 Primase zinc finger Cys_rich_KTR PF14205.6 EEA06327.1 - 0.013 15.3 3.0 0.018 14.8 1.2 2.3 2 0 0 2 2 2 0 Cysteine-rich KTR TruB_C_2 PF16198.5 EEA06327.1 - 0.16 12.1 0.0 0.45 10.7 0.0 1.7 1 0 0 1 1 1 0 tRNA pseudouridylate synthase B C-terminal domain MtrG PF04210.13 EEA06327.1 - 0.48 10.3 2.6 4.4 7.2 0.3 3.1 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Zn_Tnp_IS91 PF14319.6 EEA06327.1 - 4.6 7.3 7.5 2 8.5 2.0 2.6 1 1 1 2 2 2 0 Transposase zinc-binding domain RRM_1 PF00076.22 EEA06328.1 - 3.3e-13 49.3 0.0 4.9e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Amino_oxidase PF01593.24 EEA06329.1 - 0.48 9.6 2.9 0.66 9.2 1.2 1.9 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase PAS_9 PF13426.7 EEA06329.1 - 6 7.2 6.9 2.4 8.5 0.7 3.4 4 0 0 4 4 4 0 PAS domain RRM_1 PF00076.22 EEA06330.1 - 7.2e-13 48.2 1.5 0.0043 16.8 0.0 5.5 3 3 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNase_NucA_NucB PF14040.6 EEA06330.1 - 0.036 14.4 0.2 0.036 14.4 0.2 2.8 3 0 0 3 3 3 0 Deoxyribonuclease NucA/NucB MMR_HSR1_C PF08438.10 EEA06331.1 - 5.6e-36 123.5 1.1 9e-36 122.9 1.1 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EEA06331.1 - 1.6e-20 73.3 0.0 4.3e-20 71.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA06331.1 - 7.4e-10 38.6 2.0 9.6e-08 31.7 0.1 2.8 3 0 0 3 3 3 2 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EEA06331.1 - 0.0016 18.3 1.0 0.34 10.6 0.1 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein TGS PF02824.21 EEA06331.1 - 0.0077 16.3 0.1 0.019 15.0 0.1 1.7 1 0 0 1 1 1 1 TGS domain GTP_EFTU PF00009.27 EEA06331.1 - 0.0078 15.8 0.2 0.041 13.4 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain TSP_1 PF00090.19 EEA06332.1 - 0.00027 21.1 9.4 0.00027 21.1 9.4 4.9 4 1 0 4 4 4 3 Thrombospondin type 1 domain SRPRB PF09439.10 EEA06333.1 - 5.2e-24 84.7 1.1 1.2e-23 83.5 1.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EEA06333.1 - 1.1e-14 54.2 0.1 5.1e-14 52.1 0.1 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA06333.1 - 1.1e-05 25.5 0.0 2.4e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EEA06333.1 - 1.3e-05 24.8 0.0 3.5e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Ras family T2SSE PF00437.20 EEA06333.1 - 0.00032 19.8 0.2 0.00055 19.1 0.0 1.4 2 0 0 2 2 2 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EEA06333.1 - 0.00075 19.4 0.5 0.025 14.5 0.1 2.7 2 1 0 2 2 2 1 RsgA GTPase Roc PF08477.13 EEA06333.1 - 0.00093 19.4 0.1 0.013 15.7 0.1 2.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EEA06333.1 - 0.0011 19.5 0.1 0.0021 18.6 0.1 1.5 1 0 0 1 1 1 1 ABC transporter G-alpha PF00503.20 EEA06333.1 - 0.0021 17.3 5.9 0.0048 16.1 5.9 1.6 1 1 0 1 1 1 1 G-protein alpha subunit AAA_22 PF13401.6 EEA06333.1 - 0.0025 18.1 0.0 0.0049 17.1 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_23 PF13476.6 EEA06333.1 - 0.0062 17.1 2.8 0.012 16.1 2.6 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EEA06333.1 - 0.0079 15.9 0.3 0.017 14.9 0.3 1.6 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EEA06333.1 - 0.008 15.9 0.2 0.018 14.8 0.1 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 EEA06333.1 - 0.019 14.7 0.2 0.04 13.6 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 EEA06333.1 - 0.034 13.9 0.3 0.92 9.2 0.2 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EEA06333.1 - 0.039 14.5 0.6 0.098 13.2 0.2 1.9 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 EEA06333.1 - 0.047 13.7 0.9 0.067 13.2 0.3 1.9 2 1 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EEA06333.1 - 0.054 13.9 0.7 0.32 11.4 0.3 2.4 1 1 1 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 EEA06333.1 - 0.072 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 EEA06333.1 - 0.074 12.6 0.4 0.15 11.5 0.3 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 EEA06333.1 - 0.085 13.3 0.1 0.18 12.3 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA06333.1 - 0.094 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EEA06333.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin cobW PF02492.19 EEA06333.1 - 0.11 12.1 0.1 1.8 8.1 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 EEA06333.1 - 0.13 12.0 0.3 0.19 11.5 0.3 1.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA06333.1 - 0.19 12.0 0.0 0.31 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain HHH_2 PF12826.7 EEA06334.1 - 0.13 12.3 0.0 23 5.2 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif SPP PF06550.11 EEA06334.1 - 0.17 11.3 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease TPR_1 PF00515.28 EEA06335.1 - 3.2e-07 29.9 0.1 1.3e-06 27.9 0.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA06335.1 - 2.8e-06 27.0 0.2 7.4e-06 25.7 0.2 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA06335.1 - 0.0056 17.4 0.0 0.012 16.4 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EEA06335.1 - 0.0058 17.2 0.1 0.014 16.0 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06335.1 - 0.057 13.7 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA06335.1 - 0.064 13.5 0.1 0.19 12.1 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06335.1 - 0.075 12.7 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 TPR repeat Hydrolase_4 PF12146.8 EEA06336.1 - 1.7e-08 34.1 0.0 1e-07 31.5 0.0 2.2 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA06336.1 - 3e-07 30.3 0.4 0.0059 16.3 0.0 3.2 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA06336.1 - 3.5e-05 24.5 0.0 4.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EEA06336.1 - 0.014 14.9 0.0 0.033 13.7 0.0 1.7 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase AXE1 PF05448.12 EEA06336.1 - 0.033 12.9 0.0 0.26 9.9 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) PGAP1 PF07819.13 EEA06336.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 EEA06336.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.7 1 1 0 1 1 1 0 Lipase (class 3) Peptidase_S9 PF00326.21 EEA06336.1 - 0.16 11.4 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family CS PF04969.16 EEA06337.1 - 4.3e-06 27.6 0.1 6.4e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 CS domain Forkhead_N PF08430.12 EEA06337.1 - 0.3 11.7 2.4 0.44 11.2 2.4 1.2 1 0 0 1 1 1 0 Forkhead N-terminal region DOT1 PF08123.13 EEA06339.1 - 3.8e-05 23.3 0.0 3.8e-05 23.3 0.0 2.8 2 1 0 2 2 2 1 Histone methylation protein DOT1 DUF4023 PF13215.6 EEA06339.1 - 2.2 8.4 8.1 0.46 10.5 3.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) GpcrRhopsn4 PF10192.9 EEA06340.1 - 1.2e-07 31.5 33.9 1.2e-07 31.5 33.9 1.6 2 0 0 2 2 2 1 Rhodopsin-like GPCR transmembrane domain MFAP1 PF06991.11 EEA06342.1 - 2.8e-37 128.7 19.7 2e-36 125.9 19.7 1.9 1 1 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing MIF4G PF02854.19 EEA06343.1 - 2.6e-28 99.1 4.8 2.6e-28 99.1 4.8 2.7 2 0 0 2 2 2 1 MIF4G domain PAM2 PF07145.15 EEA06343.1 - 7.5e-10 37.8 0.3 3.4e-06 26.3 0.0 2.5 2 0 0 2 2 2 2 Ataxin-2 C-terminal region ABC_tran_CTD PF16326.5 EEA06343.1 - 2.2 8.6 10.4 12 6.2 10.4 2.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain XPG_I PF00867.18 EEA06344.1 - 2.4e-21 75.9 0.2 1.1e-20 73.7 0.0 2.3 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EEA06344.1 - 7.2e-20 71.4 0.0 6.4e-19 68.3 0.0 2.5 3 0 0 3 3 3 1 XPG N-terminal domain XPG_I_2 PF12813.7 EEA06344.1 - 0.00016 21.2 0.5 0.00036 20.1 0.2 1.6 1 1 1 2 2 2 1 XPG domain containing 5_3_exonuc PF01367.20 EEA06344.1 - 0.0013 19.3 1.4 0.014 16.0 0.0 2.7 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EEA06344.1 - 0.081 13.5 0.1 21 5.8 0.1 3.4 3 1 0 3 3 3 0 Helix-hairpin-helix domain Apyrase PF06079.11 EEA06345.1 - 6.5e-110 366.9 0.1 7.5e-110 366.7 0.1 1.0 1 0 0 1 1 1 1 Apyrase DASH_Spc19 PF08287.11 EEA06346.1 - 0.58 10.0 5.0 1.6 8.6 5.0 1.7 1 0 0 1 1 1 0 Spc19 DNA_pol_phi PF04931.13 EEA06346.1 - 3.5 5.6 13.3 6.2 4.8 13.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF572 PF04502.13 EEA06347.1 - 1.2e-53 182.9 9.1 1.4e-53 182.6 9.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.14 EEA06347.1 - 0.015 15.3 0.6 1.6 8.7 0.1 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif HalOD2 PF18547.1 EEA06347.1 - 0.13 12.2 0.2 7.9 6.5 0.1 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 NuA4 PF09340.10 EEA06348.1 - 3.9e-20 71.5 1.1 4.7e-20 71.2 0.2 1.6 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 SLBP_RNA_bind PF15247.6 EEA06349.1 - 2.8e-18 65.8 2.7 2.8e-18 65.8 2.7 2.1 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain BHD_3 PF10405.9 EEA06350.1 - 2.8e-17 62.9 0.0 8.2e-17 61.4 0.0 1.8 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EEA06350.1 - 6.2e-13 48.4 0.1 1.5e-12 47.1 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 EEA06350.1 - 7.6e-09 35.4 1.2 0.00011 21.9 0.4 2.8 2 0 0 2 2 2 2 Rad4 transglutaminase-like domain BHD_2 PF10404.9 EEA06350.1 - 0.031 15.2 4.9 0.41 11.6 2.8 3.0 2 1 0 2 2 2 0 Rad4 beta-hairpin domain 2 UPF0004 PF00919.20 EEA06351.1 - 4.6e-18 65.1 0.5 1.2e-17 63.7 0.1 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 EEA06351.1 - 7.2e-18 65.5 0.0 1.3e-17 64.7 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.20 EEA06351.1 - 0.0087 16.0 0.0 0.66 10.0 0.1 2.7 2 0 0 2 2 2 1 TRAM domain PKD_channel PF08016.12 EEA06352.1 - 0.0049 15.6 20.9 0.0091 14.7 20.9 1.3 1 0 0 1 1 1 1 Polycystin cation channel DPM2 PF07297.12 EEA06352.1 - 0.31 11.4 9.4 0.25 11.7 5.9 2.7 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF3273 PF11677.8 EEA06353.1 - 2.8e-85 285.9 12.9 3.2e-85 285.7 12.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3273) RP853 PF17542.2 EEA06353.1 - 0.2 10.7 0.1 0.3 10.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized RP853 SLATT_5 PF18160.1 EEA06353.1 - 0.99 8.7 2.8 1.7 8.0 2.8 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF1422 PF07226.11 EEA06353.1 - 2.8 8.0 7.3 0.64 10.0 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) EMC3_TMCO1 PF01956.16 EEA06354.1 - 2.4e-14 53.4 2.3 4.3e-14 52.6 2.2 1.3 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like RE_AlwI PF09491.10 EEA06354.1 - 0.007 15.2 0.3 0.0084 15.0 0.3 1.1 1 0 0 1 1 1 1 AlwI restriction endonuclease Orf78 PF06024.12 EEA06354.1 - 0.036 14.3 1.8 0.046 14.0 0.8 1.7 2 0 0 2 2 2 0 Orf78 (ac78) TetR PF13972.6 EEA06355.1 - 0.0066 16.2 0.0 0.022 14.4 0.0 1.8 2 0 0 2 2 2 1 Bacterial transcriptional repressor CLP1_P PF16575.5 EEA06355.1 - 0.019 14.8 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SET PF00856.28 EEA06356.1 - 4.6e-09 36.9 0.0 4.6e-09 36.9 0.0 3.3 3 1 0 3 3 3 1 SET domain PRC2_HTH_1 PF18118.1 EEA06356.1 - 0.073 13.9 1.7 0.33 11.8 1.7 2.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain CRAL_TRIO PF00650.20 EEA06357.1 - 4.1e-34 117.6 0.2 6.4e-34 117.0 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EEA06357.1 - 1.8e-07 31.2 0.3 5.6e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EEA06357.1 - 0.032 14.4 0.2 0.083 13.1 0.0 1.8 2 1 0 2 2 2 0 Divergent CRAL/TRIO domain Rep_Org_C PF06926.11 EEA06357.1 - 0.074 13.4 0.6 12 6.3 0.0 2.9 2 1 1 3 3 3 0 Putative replisome organiser protein C-terminus PS_pyruv_trans PF04230.13 EEA06358.1 - 4.6e-18 66.2 2.2 1.3e-17 64.7 1.9 2.0 1 1 0 1 1 1 1 Polysaccharide pyruvyl transferase Fringe PF02434.16 EEA06358.1 - 2.5e-14 53.4 0.1 5.6e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EEA06358.1 - 3.1e-10 40.2 0.0 8e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Galactosyltransferase DUF4047 PF13256.6 EEA06358.1 - 1.5 9.0 4.6 3.4 7.9 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) ATG16 PF08614.11 EEA06359.1 - 0.0097 16.2 6.2 0.0097 16.2 6.2 4.6 3 1 2 5 5 5 2 Autophagy protein 16 (ATG16) MPS-4 PF17523.2 EEA06360.1 - 0.0011 19.0 0.7 0.0028 17.7 0.7 1.7 1 0 0 1 1 1 1 MinK-related peptide, potassium channel accessory sub-unit protein 4 Myb_DNA-bind_4 PF13837.6 EEA06360.1 - 0.84 10.1 6.8 1.9 8.9 6.6 1.8 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain LapA_dom PF06305.11 EEA06360.1 - 1 9.2 4.0 2.6 7.9 0.2 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain E2F_TDP PF02319.20 EEA06361.1 - 4.9e-14 52.1 0.0 1.1e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Lip_prot_lig_C PF10437.9 EEA06362.1 - 5.6e-20 71.1 0.4 1.6e-18 66.5 0.1 3.0 2 1 0 2 2 2 1 Bacterial lipoate protein ligase C-terminus BPL_LplA_LipB PF03099.19 EEA06362.1 - 1.3e-10 41.3 0.1 1e-09 38.4 0.1 2.3 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Pkinase PF00069.25 EEA06363.1 - 2.3e-59 200.9 0.0 5.1e-59 199.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06363.1 - 3.8e-29 101.8 0.0 1.1e-28 100.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EEA06363.1 - 0.1 11.6 0.1 0.19 10.7 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Bul1_C PF04426.12 EEA06363.1 - 0.13 11.7 1.2 0.24 10.8 1.2 1.4 1 0 0 1 1 1 0 Bul1 C terminus OB_NTP_bind PF07717.16 EEA06364.1 - 7.2e-25 87.2 0.0 1.5e-24 86.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EEA06364.1 - 8.1e-24 84.0 0.0 2.7e-23 82.3 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EEA06364.1 - 1.4e-11 44.7 0.0 3.6e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA06364.1 - 5.1e-07 29.6 0.1 1.2e-06 28.4 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA06364.1 - 2.7e-06 27.7 0.0 8.3e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA06364.1 - 0.002 18.5 0.0 0.0048 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EEA06364.1 - 0.0022 17.1 0.0 0.0052 15.9 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 EEA06364.1 - 0.003 18.1 0.9 0.5 10.9 0.4 3.4 2 1 0 2 2 2 1 ABC transporter DUF2075 PF09848.9 EEA06364.1 - 0.016 14.4 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EEA06364.1 - 0.018 14.7 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EEA06364.1 - 0.031 13.7 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 EEA06364.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF4358 PF14270.6 EEA06364.1 - 0.066 13.5 0.2 3.2 8.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) AAA_14 PF13173.6 EEA06364.1 - 0.073 13.1 0.2 3.9 7.5 0.2 2.8 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 EEA06364.1 - 0.075 12.7 0.1 0.29 10.7 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EEA06364.1 - 0.14 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EEA06364.1 - 0.17 11.7 0.0 2.5 7.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain ING PF12998.7 EEA06365.1 - 0.0022 18.5 0.9 0.71 10.5 3.4 2.2 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding Med21 PF11221.8 EEA06365.1 - 0.0027 18.0 4.5 0.58 10.4 1.5 2.4 2 1 0 2 2 2 2 Subunit 21 of Mediator complex CdvA PF18822.1 EEA06365.1 - 0.019 14.8 4.8 0.03 14.1 4.8 1.4 1 0 0 1 1 1 0 CdvA-like coiled-coil domain bZIP_1 PF00170.21 EEA06365.1 - 0.048 13.8 2.1 0.048 13.8 2.1 2.4 2 1 1 3 3 3 0 bZIP transcription factor DUF2175 PF09943.9 EEA06365.1 - 0.17 12.2 2.8 0.27 11.5 2.1 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) GAT PF03127.14 EEA06365.1 - 0.23 11.8 4.3 0.33 11.3 2.6 2.2 3 1 0 3 3 3 0 GAT domain Ribosom_S12_S23 PF00164.25 EEA06366.1 - 1.9e-50 169.2 0.5 2.4e-50 168.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Methyltransf_15 PF09445.10 EEA06366.1 - 0.0022 17.6 0.0 0.0024 17.5 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PHD_4 PF16866.5 EEA06367.1 - 0.088 12.9 0.6 0.17 12.0 0.6 1.4 1 0 0 1 1 1 0 PHD-finger Hist_deacetyl PF00850.19 EEA06368.1 - 1.2e-76 258.1 0.0 1.6e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Hus1 PF04005.12 EEA06369.1 - 4.4e-17 62.1 1.1 6.4e-17 61.6 1.1 1.2 1 0 0 1 1 1 1 Hus1-like protein FmiP_Thoc5 PF09766.9 EEA06371.1 - 1.3e-13 51.0 11.9 1.1e-06 28.2 10.7 2.4 1 1 1 2 2 2 2 Fms-interacting protein/Thoc5 SLIDE PF09111.10 EEA06371.1 - 0.01 15.8 1.2 0.01 15.8 1.2 2.9 2 1 1 3 3 3 0 SLIDE Prefoldin_2 PF01920.20 EEA06371.1 - 0.092 12.7 8.2 0.065 13.2 3.1 3.1 2 1 1 3 3 3 0 Prefoldin subunit Tox-REase-7 PF15649.6 EEA06371.1 - 0.15 12.4 1.9 7.6 6.9 0.1 2.8 2 1 1 3 3 3 0 Restriction endonuclease fold toxin 7 MCU PF04678.13 EEA06371.1 - 0.2 11.7 1.1 0.33 11.0 1.1 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter PI_PP_I PF18363.1 EEA06371.1 - 0.24 11.6 5.8 0.14 12.4 0.3 3.1 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain DUF5320 PF17253.2 EEA06371.1 - 1.5 9.9 2.4 4.4 8.4 2.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5320) DUF3450 PF11932.8 EEA06371.1 - 1.6 8.0 8.4 1.5 8.1 4.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.22 EEA06371.1 - 2 8.7 11.9 0.41 10.9 4.6 2.7 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF87 PF01935.17 EEA06371.1 - 2 8.4 7.8 1 9.4 4.6 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain GrpE PF01025.19 EEA06371.1 - 2 8.0 7.8 3.4 7.3 3.0 2.3 1 1 1 2 2 2 0 GrpE STAT_alpha PF01017.20 EEA06371.1 - 2.1 8.2 13.9 0.45 10.4 5.8 2.5 1 1 0 2 2 2 0 STAT protein, all-alpha domain APG6_N PF17675.1 EEA06371.1 - 4.5 7.8 13.4 0.69 10.4 7.4 2.5 3 0 0 3 3 3 0 Apg6 coiled-coil region NPR3 PF03666.13 EEA06372.1 - 0.0023 16.8 0.2 0.0031 16.4 0.2 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 PRAP PF15314.6 EEA06372.1 - 0.11 13.0 4.2 3.2 8.3 0.1 2.8 3 0 0 3 3 3 0 Proline-rich acidic protein 1, pregnancy-specific uterine DUF737 PF05300.11 EEA06372.1 - 0.12 12.8 3.5 0.1 13.0 2.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF737) H_lectin PF09458.10 EEA06373.1 - 0.15 12.3 0.9 0.46 10.7 0.4 2.1 2 0 0 2 2 2 0 H-type lectin domain zf-CCCH PF00642.24 EEA06374.1 - 1.6e-13 50.2 12.6 4.2e-07 29.7 0.1 3.3 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EEA06374.1 - 6e-07 30.1 6.6 0.00053 20.7 2.4 2.6 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 EEA06374.1 - 7e-07 28.9 9.3 3.2e-05 23.6 0.2 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EEA06374.1 - 2.6e-06 27.3 0.7 2.6e-06 27.3 0.7 4.0 3 1 1 4 4 4 1 Zinc finger domain zf-CCCH_2 PF14608.6 EEA06374.1 - 0.0061 17.0 8.1 0.55 10.8 0.0 3.6 3 1 0 3 3 3 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EEA06374.1 - 0.026 14.7 6.9 0.91 9.8 1.8 2.4 1 1 1 2 2 2 0 Zinc-finger containing family zf-C3H1 PF10650.9 EEA06374.1 - 1.6 8.6 12.9 0.12 12.1 0.8 3.7 4 0 0 4 4 4 0 Putative zinc-finger domain PAN_4 PF14295.6 EEA06378.1 - 2.1e-05 24.3 12.9 0.00076 19.3 0.0 3.5 3 1 0 3 3 3 2 PAN domain PAN_1 PF00024.26 EEA06378.1 - 0.00048 20.0 10.5 0.0051 16.7 2.3 3.0 2 1 0 2 2 2 2 PAN domain TSP_1 PF00090.19 EEA06378.1 - 0.12 12.6 0.1 0.12 12.6 0.1 5.4 3 1 2 5 5 5 0 Thrombospondin type 1 domain zf-RING_2 PF13639.6 EEA06379.1 - 2e-09 37.6 13.3 2e-09 37.6 13.3 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EEA06379.1 - 1.2e-07 31.3 5.1 3.9e-07 29.7 5.1 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EEA06379.1 - 1.3e-06 28.5 10.9 6.1e-06 26.4 10.9 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EEA06379.1 - 7.3e-06 25.8 9.0 7.3e-06 25.8 9.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA06379.1 - 1.8e-05 24.5 11.7 5.5e-05 22.9 11.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA06379.1 - 0.00015 21.6 9.9 0.00015 21.6 9.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA06379.1 - 0.0043 17.1 6.2 0.0043 17.1 6.2 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EEA06379.1 - 0.015 15.1 9.0 0.045 13.6 9.0 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA06379.1 - 0.025 14.5 10.4 0.025 14.5 10.4 2.2 2 0 0 2 2 2 0 zinc-RING finger domain TMEM154 PF15102.6 EEA06379.1 - 0.029 14.3 1.1 0.17 11.8 0.0 2.3 2 1 1 3 3 3 0 TMEM154 protein family RPAP2_Rtr1 PF04181.13 EEA06379.1 - 6.8 7.1 11.5 0.19 12.0 0.7 2.6 2 1 0 2 2 2 0 Rtr1/RPAP2 family DUF2967 PF11179.8 EEA06380.1 - 0.0093 14.1 3.2 0.014 13.6 3.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2967) Acyltransferase PF01553.21 EEA06381.1 - 3.4e-15 55.8 0.0 4.6e-14 52.2 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase DUF3730 PF12530.8 EEA06382.1 - 0.0046 16.6 0.0 0.02 14.5 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3730) CLP1_P PF16575.5 EEA06384.1 - 2.1e-20 73.3 0.2 4.5e-20 72.2 0.0 1.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ATPase_2 PF01637.18 EEA06384.1 - 0.012 15.5 0.4 0.06 13.3 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EEA06384.1 - 0.015 15.3 0.7 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA06384.1 - 0.053 13.3 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EEA06384.1 - 0.078 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 EEA06384.1 - 0.13 12.0 0.0 0.43 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain TRAP_beta PF05753.14 EEA06385.1 - 0.016 14.6 0.1 0.023 14.1 0.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) Methyltransf_PK PF05891.12 EEA06386.1 - 1.3e-46 158.8 0.1 1.7e-46 158.5 0.1 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EEA06386.1 - 1e-06 29.4 0.0 2.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA06386.1 - 2.2e-05 25.0 0.0 4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EEA06386.1 - 0.0002 21.1 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_12 PF08242.12 EEA06386.1 - 0.0063 17.2 0.1 0.02 15.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain ELFV_dehydrog PF00208.21 EEA06386.1 - 0.19 11.4 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TP_methylase PF00590.20 EEA06387.1 - 1.3e-24 87.4 0.0 2e-24 86.7 0.0 1.3 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DnaJ PF00226.31 EEA06388.1 - 2.2e-22 78.9 5.0 4.4e-22 78.0 0.6 2.5 2 0 0 2 2 2 1 DnaJ domain DASH_Ask1 PF08655.10 EEA06388.1 - 0.089 12.7 0.5 0.089 12.7 0.5 2.9 3 0 0 3 3 3 0 DASH complex subunit Ask1 LRR19-TM PF15176.6 EEA06388.1 - 0.13 12.3 4.5 0.093 12.7 1.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain HECT PF00632.25 EEA06389.1 - 7.1e-14 52.0 1.1 7.1e-14 52.0 1.1 2.9 2 1 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF948 PF06103.11 EEA06392.1 - 0.056 13.7 0.9 0.056 13.7 0.9 2.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AI-2E_transport PF01594.16 EEA06392.1 - 0.095 11.8 1.4 0.15 11.1 1.4 1.3 1 0 0 1 1 1 0 AI-2E family transporter TTRAP PF14203.6 EEA06392.1 - 0.21 11.6 3.2 8.9 6.4 0.4 3.3 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein EMC3_TMCO1 PF01956.16 EEA06392.1 - 0.61 9.8 5.0 0.1 12.3 0.4 2.1 2 1 1 3 3 3 0 Integral membrane protein EMC3/TMCO1-like AP2 PF00847.20 EEA06393.1 - 2.7e-07 30.7 10.5 5.6e-05 23.3 2.2 2.9 3 0 0 3 3 3 2 AP2 domain DUF1308 PF07000.11 EEA06393.1 - 0.08 12.9 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) FTR_C PF02741.15 EEA06393.1 - 0.15 12.1 0.5 0.83 9.7 0.1 2.2 2 0 0 2 2 2 0 FTR, proximal lobe Peptidase_C92 PF05708.12 EEA06394.1 - 0.066 13.3 0.2 0.18 11.9 0.2 1.7 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Flavodoxin_2 PF02525.17 EEA06395.1 - 1.1e-12 48.1 0.0 1.2e-12 48.0 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold DnaJ PF00226.31 EEA06397.1 - 1.7e-17 63.3 0.2 4.3e-17 62.0 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain Spec3 PF15795.5 EEA06398.1 - 0.00095 19.7 7.3 0.00095 19.7 7.3 2.1 1 1 1 2 2 2 2 Ectodermal ciliogenesis protein DUF3040 PF11239.8 EEA06398.1 - 0.18 12.1 1.7 0.32 11.3 1.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) SidE PF12252.8 EEA06402.1 - 0.013 13.1 3.0 0.018 12.6 3.0 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein TRCF PF03461.15 EEA06402.1 - 0.097 13.1 0.0 0.29 11.5 0.0 1.8 1 0 0 1 1 1 0 TRCF domain COG2 PF06148.11 EEA06402.1 - 0.26 11.4 2.5 0.35 11.0 1.0 1.9 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Prominin PF05478.11 EEA06402.1 - 0.34 8.8 10.6 0.12 10.3 6.8 1.9 2 1 0 2 2 2 0 Prominin ApoLp-III PF07464.11 EEA06402.1 - 0.78 9.8 5.5 1.6 8.8 5.5 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) BLOC1_2 PF10046.9 EEA06402.1 - 0.79 10.1 5.1 9.5 6.6 1.0 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin-6_N PF09177.11 EEA06402.1 - 0.81 10.3 4.3 3.5 8.2 0.4 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.12 EEA06402.1 - 2.1 8.4 17.3 9.3 6.3 8.2 3.6 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Focal_AT PF03623.13 EEA06402.1 - 2.2 8.3 4.9 1.5 8.8 1.1 2.5 3 0 0 3 3 3 0 Focal adhesion targeting region DUF948 PF06103.11 EEA06402.1 - 2.8 8.3 5.1 2.4 8.5 0.6 3.1 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) ATP-synt_ab PF00006.25 EEA06403.1 - 7.7e-63 212.0 0.0 1.3e-62 211.2 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EEA06403.1 - 2.3e-20 72.9 0.2 4.1e-20 72.1 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 EEA06403.1 - 0.0037 17.7 0.2 0.32 11.4 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RnfC_N PF13375.6 EEA06403.1 - 0.0093 15.9 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain ATPase PF06745.13 EEA06403.1 - 0.011 15.1 1.3 0.015 14.6 0.3 1.7 2 0 0 2 2 2 0 KaiC RsgA_GTPase PF03193.16 EEA06403.1 - 0.028 14.3 0.0 0.062 13.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 EEA06403.1 - 0.035 14.0 0.0 0.091 12.7 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EEA06403.1 - 0.059 12.6 1.0 0.069 12.3 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 EEA06403.1 - 0.065 13.6 0.0 0.18 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 EEA06403.1 - 0.079 13.3 0.7 0.25 11.7 0.1 1.9 2 0 0 2 2 2 0 AAA domain T3SS_ATPase_C PF18269.1 EEA06403.1 - 0.12 12.2 0.6 0.32 10.9 0.6 1.7 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain NACHT PF05729.12 EEA06403.1 - 0.13 12.2 0.2 0.36 10.7 0.0 1.8 2 0 0 2 2 2 0 NACHT domain TrwB_AAD_bind PF10412.9 EEA06403.1 - 0.16 10.8 0.1 0.27 10.1 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ATP-synt_DE_N PF02823.16 EEA06404.1 - 2.1e-11 43.6 0.0 2.7e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain AAA PF00004.29 EEA06405.1 - 7.4e-42 142.9 0.0 1.8e-41 141.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EEA06405.1 - 4.8e-20 71.3 0.1 1e-19 70.2 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EEA06405.1 - 6.6e-12 45.0 0.1 1.4e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EEA06405.1 - 5.4e-06 26.5 1.2 2.3e-05 24.4 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA06405.1 - 5.9e-05 23.5 0.4 0.0039 17.6 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain TMF_TATA_bd PF12325.8 EEA06405.1 - 0.00012 22.3 3.3 0.00012 22.3 3.3 1.9 3 0 0 3 3 1 1 TATA element modulatory factor 1 TATA binding RuvB_N PF05496.12 EEA06405.1 - 0.00013 21.7 0.0 0.00035 20.4 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA06405.1 - 0.00037 20.8 0.9 0.087 13.1 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 EEA06405.1 - 0.00069 19.8 0.0 0.0033 17.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF1640 PF07798.11 EEA06405.1 - 0.0031 17.6 1.7 0.0056 16.8 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) AAA_33 PF13671.6 EEA06405.1 - 0.0036 17.5 0.0 0.0094 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EEA06405.1 - 0.0052 16.2 0.1 0.014 14.7 0.0 1.7 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI TolA_bind_tri PF16331.5 EEA06405.1 - 0.0061 16.6 5.6 0.0082 16.2 2.7 2.3 2 0 0 2 2 2 1 TolA binding protein trimerisation DUF815 PF05673.13 EEA06405.1 - 0.01 15.0 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 EEA06405.1 - 0.014 14.9 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 EEA06405.1 - 0.02 14.3 0.7 0.2 11.0 0.0 2.3 2 0 0 2 2 2 0 KaiC IstB_IS21 PF01695.17 EEA06405.1 - 0.023 14.4 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein KELK PF15796.5 EEA06405.1 - 0.046 14.2 1.8 0.046 14.2 1.8 1.9 2 0 0 2 2 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase AAA_24 PF13479.6 EEA06405.1 - 0.049 13.3 0.1 0.11 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF1192 PF06698.11 EEA06405.1 - 0.063 13.3 0.2 0.16 12.0 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) Cep57_MT_bd PF06657.13 EEA06405.1 - 0.074 13.5 1.0 0.2 12.1 1.0 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Sigma54_activat PF00158.26 EEA06405.1 - 0.08 12.6 0.0 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 EEA06405.1 - 0.08 12.7 0.4 0.69 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 EEA06405.1 - 0.086 12.0 0.3 0.17 11.0 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_7 PF12775.7 EEA06405.1 - 0.099 12.2 0.5 0.23 11.0 0.0 1.8 2 1 0 2 2 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EEA06405.1 - 0.17 12.3 0.0 0.34 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase bZIP_1 PF00170.21 EEA06405.1 - 0.17 12.0 2.8 0.41 10.8 2.8 1.7 1 0 0 1 1 1 0 bZIP transcription factor ZapB PF06005.12 EEA06405.1 - 0.23 11.9 7.5 0.24 11.9 5.3 2.1 2 0 0 2 2 2 0 Cell division protein ZapB FlaC_arch PF05377.11 EEA06405.1 - 0.38 11.2 4.7 0.44 11.0 3.2 1.9 2 0 0 2 2 1 0 Flagella accessory protein C (FlaC) PI3_PI4_kinase PF00454.27 EEA06406.1 - 4.2e-39 134.8 0.0 8e-39 134.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DnaJ_C PF01556.18 EEA06408.1 - 2.9e-31 108.5 0.2 3.9e-31 108.1 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA06408.1 - 7.8e-21 74.0 0.1 1.4e-20 73.1 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA06408.1 - 4.5e-12 46.2 16.5 8.6e-12 45.3 16.5 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EEA06408.1 - 0.0011 18.9 14.1 0.0038 17.2 1.0 3.3 1 1 3 4 4 4 3 Tryptophan RNA-binding attenuator protein inhibitory protein DUF1217 PF06748.12 EEA06408.1 - 0.0026 17.8 0.0 0.02 14.9 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1217) Pkinase PF00069.25 EEA06411.1 - 1.6e-75 253.9 0.0 3.1e-75 252.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06411.1 - 6.2e-31 107.6 0.0 1.2e-30 106.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EEA06411.1 - 4.3e-27 91.6 2.9 2.2e-06 26.8 0.5 4.8 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA06411.1 - 7.1e-25 87.3 3.3 3.2e-12 46.7 0.6 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA06411.1 - 3.1e-24 83.3 2.3 4.3e-06 26.0 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EEA06411.1 - 2.5e-21 73.7 3.7 0.0004 20.1 0.0 5.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EEA06411.1 - 1.6e-19 69.5 7.1 6e-10 38.8 0.4 4.4 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA06411.1 - 3.7e-07 30.5 1.8 0.013 15.9 0.2 3.0 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EEA06411.1 - 4.2e-05 23.8 0.2 0.0032 17.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain APH PF01636.23 EEA06411.1 - 0.0038 17.2 0.0 0.0067 16.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA06411.1 - 0.026 13.9 0.2 0.076 12.4 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_4 PF12763.7 EEA06411.1 - 0.2 11.6 1.1 7 6.7 0.2 2.8 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DDHD PF02862.17 EEA06413.1 - 6.2e-38 131.2 0.1 3.5e-37 128.7 0.0 2.1 2 0 0 2 2 2 1 DDHD domain Thioesterase PF00975.20 EEA06413.1 - 0.0011 19.1 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EEA06413.1 - 0.0012 19.4 0.0 0.0029 18.2 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EEA06413.1 - 0.012 15.3 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA06413.1 - 0.014 14.7 0.0 0.036 13.3 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 EEA06413.1 - 0.016 14.9 0.0 0.052 13.3 0.0 1.9 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.14 EEA06413.1 - 0.02 14.4 0.0 6.2 6.3 0.0 2.7 3 0 0 3 3 3 0 Putative serine esterase (DUF676) LIDHydrolase PF10230.9 EEA06413.1 - 0.023 14.3 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 EEA06413.1 - 0.034 14.0 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_8 PF06259.12 EEA06413.1 - 0.2 11.3 0.0 0.42 10.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Guanylate_cyc PF00211.20 EEA06414.1 - 1.3e-16 60.8 0.1 5.1e-16 58.8 0.0 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain COG2 PF06148.11 EEA06415.1 - 1.7e-06 28.1 0.7 7.8e-06 26.0 0.7 2.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 EEA06415.1 - 0.0061 16.9 0.1 0.037 14.4 0.1 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) Med2 PF11214.8 EEA06416.1 - 0.3 11.3 6.1 0.77 10.0 0.3 3.0 3 0 0 3 3 3 0 Mediator complex subunit 2 MCM PF00493.23 EEA06417.1 - 6.1e-94 313.3 0.0 1.2e-92 309.1 0.0 2.2 1 1 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA06417.1 - 1.1e-33 115.8 0.3 2.8e-33 114.4 0.3 1.7 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA06417.1 - 5.8e-27 94.0 0.3 1.4e-26 92.7 0.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EEA06417.1 - 1.9e-05 24.1 0.0 0.00025 20.5 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EEA06417.1 - 2.9e-05 24.6 0.8 0.001 19.6 0.1 3.3 2 1 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EEA06417.1 - 0.0001 22.3 0.0 0.00055 19.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EEA06417.1 - 0.0053 16.6 0.0 0.018 14.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA06417.1 - 0.013 15.9 0.2 1.5 9.2 0.0 2.7 1 1 1 2 2 2 0 AAA ATPase domain Ku_PK_bind PF08785.11 EEA06417.1 - 0.079 13.1 0.0 0.37 11.0 0.0 2.1 2 0 0 2 2 2 0 Ku C terminal domain like EF-hand_4 PF12763.7 EEA06418.1 - 1.3e-19 70.0 1.9 9.5e-11 41.6 0.5 3.3 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EEA06418.1 - 7.4e-10 37.7 7.8 0.01 15.3 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EEA06418.1 - 1.2e-09 38.5 7.5 2.2e-07 31.2 0.2 3.8 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA06418.1 - 2.9e-06 26.7 8.5 0.031 14.2 0.1 4.4 5 0 0 5 5 5 2 EF-hand domain EF-hand_5 PF13202.6 EEA06418.1 - 0.00016 21.0 2.9 0.27 10.8 0.1 3.1 2 0 0 2 2 2 2 EF hand DUF3450 PF11932.8 EEA06418.1 - 0.024 14.0 4.7 0.066 12.5 4.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) EF-hand_8 PF13833.6 EEA06418.1 - 0.076 12.9 5.1 17 5.4 0.0 4.6 5 0 0 5 5 5 0 EF-hand domain pair Cep57_MT_bd PF06657.13 EEA06418.1 - 0.6 10.6 7.8 0.48 10.9 4.9 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF848 PF05852.11 EEA06418.1 - 2 8.5 11.5 3.6 7.7 4.1 2.6 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CENP-H PF05837.12 EEA06418.1 - 7.9 6.9 11.7 1.1 9.6 5.8 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ER PF01133.17 EEA06420.1 - 0.0043 17.0 1.5 0.64 10.1 0.1 3.0 2 0 0 2 2 2 2 Enhancer of rudimentary DENN PF02141.21 EEA06421.1 - 8.9e-22 77.9 9.4 3.3e-21 76.1 9.4 2.0 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EEA06421.1 - 2.7e-06 28.0 0.3 3e-05 24.7 0.0 2.7 2 0 0 2 2 2 1 uDENN domain Pkinase PF00069.25 EEA06422.1 - 0.027 13.8 0.0 0.17 11.2 0.0 2.2 3 0 0 3 3 3 0 Protein kinase domain PTS_2-RNA PF01885.16 EEA06423.1 - 4.1e-47 160.6 0.0 5e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Steroid_dh PF02544.16 EEA06424.1 - 1.8e-33 115.6 9.2 1.8e-33 115.6 9.2 1.6 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Ubiquitin_4 PF18036.1 EEA06424.1 - 0.007 16.4 0.0 0.036 14.1 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-like domain Methyltransf_15 PF09445.10 EEA06426.1 - 3.3e-26 91.8 0.9 2.8e-15 56.3 0.2 3.2 2 1 0 2 2 2 2 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EEA06426.1 - 0.004 17.8 0.0 0.012 16.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EEA06426.1 - 0.012 15.3 0.1 0.11 12.1 0.0 2.5 3 0 0 3 3 3 0 Conserved hypothetical protein 95 zf-ZPR1 PF03367.13 EEA06427.1 - 1.6e-102 340.1 0.7 5.1e-52 175.9 0.1 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EEA06427.1 - 0.0036 17.3 6.1 0.5 10.4 0.6 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RVP_2 PF08284.11 EEA06427.1 - 0.025 14.4 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zinc_ribbon_2 PF13240.6 EEA06427.1 - 0.046 13.4 11.7 8 6.3 0.5 4.5 4 0 0 4 4 4 0 zinc-ribbon domain DUF5001 PF16392.5 EEA06427.1 - 0.1 12.5 0.2 2.2 8.2 0.0 2.6 3 0 0 3 3 3 0 Ig-like domain Zn-ribbon_8 PF09723.10 EEA06427.1 - 0.67 10.1 5.5 21 5.3 0.0 3.9 4 0 0 4 4 4 0 Zinc ribbon domain zf-Mss51 PF13824.6 EEA06427.1 - 0.78 9.9 4.1 44 4.3 2.2 2.8 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-ribbon_3 PF13248.6 EEA06427.1 - 0.83 9.2 15.5 4.5 6.8 1.3 4.2 4 0 0 4 4 4 0 zinc-ribbon domain DUF983 PF06170.12 EEA06427.1 - 4.8 7.7 5.9 45 4.5 3.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF983) zf-RRPl_C4 PF17026.5 EEA06427.1 - 7.7 6.7 6.7 1.2 9.2 0.6 2.5 3 0 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type Terminase_GpA PF05876.12 EEA06427.1 - 8.2 4.8 5.1 0.69 8.4 0.3 1.5 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) Rhomboid PF01694.22 EEA06428.1 - 1.4e-19 70.5 3.4 2.2e-19 70.0 3.4 1.2 1 0 0 1 1 1 1 Rhomboid family Paf67 PF10255.9 EEA06429.1 - 2.7e-121 405.4 3.7 3.5e-121 405.0 3.7 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EEA06429.1 - 0.0015 18.5 0.1 0.0046 17.0 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3826 PF12875.7 EEA06429.1 - 0.016 15.4 0.1 0.036 14.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) TPR_1 PF00515.28 EEA06429.1 - 0.082 12.8 0.1 0.35 10.8 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 EEA06430.1 - 7.5e-26 89.1 48.1 1.3e-05 25.3 2.1 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EEA06430.1 - 5.8e-22 76.5 51.8 0.00054 20.6 1.1 8.1 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EEA06430.1 - 5.5e-13 48.7 48.0 4.4e-06 26.9 0.9 9.0 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 EEA06430.1 - 1.2e-07 31.5 33.9 0.0012 18.8 0.1 6.8 7 1 0 7 7 6 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EEA06430.1 - 2.2e-06 27.3 34.9 0.078 12.7 1.0 6.4 7 0 0 7 7 7 4 zinc-finger C2H2-type FOXP-CC PF16159.5 EEA06430.1 - 1.4e-05 25.6 18.4 0.51 11.0 0.2 6.4 3 2 3 7 7 7 3 FOXP coiled-coil domain zf_UBZ PF18439.1 EEA06430.1 - 0.0031 17.1 3.3 6 6.6 0.0 4.0 4 0 0 4 4 3 1 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 EEA06430.1 - 0.0041 17.5 27.1 0.27 11.7 0.1 7.3 7 1 0 7 7 7 2 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 EEA06430.1 - 0.0041 17.8 19.0 0.022 15.5 5.9 4.0 1 1 3 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf_C2H2_ZHX PF18387.1 EEA06430.1 - 0.0058 16.2 18.0 2.1 8.0 0.2 5.1 2 1 3 5 5 5 3 Zinc-fingers and homeoboxes C2H2 finger domain Ribosomal_S26e PF01283.19 EEA06430.1 - 0.012 16.0 0.3 1.7 9.1 0.2 2.6 1 1 1 2 2 2 0 Ribosomal protein S26e PBECR3 PF18812.1 EEA06430.1 - 0.017 15.0 1.4 4.9 7.1 0.0 4.0 4 1 1 5 5 5 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 zf-C2H2_jaz PF12171.8 EEA06430.1 - 0.05 13.9 25.0 0.8 10.1 0.2 7.9 7 1 1 8 8 8 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 EEA06430.1 - 0.21 11.2 0.0 0.21 11.2 0.0 6.1 4 3 2 6 6 5 0 MYST family zinc finger domain zf-C2H2_aberr PF17017.5 EEA06430.1 - 0.29 11.2 22.5 1.5 8.9 4.4 4.1 4 0 0 4 4 4 0 Aberrant zinc-finger DUF629 PF04780.12 EEA06430.1 - 0.53 8.7 24.2 2.4 6.6 0.6 5.3 2 2 4 6 6 6 0 Protein of unknown function (DUF629) zf_Hakai PF18408.1 EEA06430.1 - 5.1 6.9 17.0 11 5.8 1.8 4.8 5 0 0 5 5 5 0 C2H2 Hakai zinc finger domain Syntaxin PF00804.25 EEA06431.1 - 3.7e-20 72.5 20.3 2.4e-16 60.0 20.3 2.2 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 EEA06431.1 - 3.2e-12 46.3 1.3 3.2e-12 46.3 1.3 2.1 2 0 0 2 2 2 1 SNARE domain IF-2 PF11987.8 EEA06431.1 - 0.0017 18.4 0.6 0.0017 18.4 0.6 1.8 2 0 0 2 2 2 1 Translation-initiation factor 2 CRISPR_Cse1 PF09481.10 EEA06431.1 - 0.0072 15.5 0.4 0.01 15.0 0.4 1.1 1 0 0 1 1 1 1 CRISPR-associated protein Cse1 (CRISPR_cse1) LMBR1 PF04791.16 EEA06431.1 - 0.01 14.8 11.0 0.014 14.3 11.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Glyco_hydro_99 PF16317.5 EEA06431.1 - 0.034 13.3 0.1 0.067 12.3 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 99 Cep57_CLD_2 PF14197.6 EEA06431.1 - 0.18 11.9 9.4 3.3 7.8 1.3 3.4 2 1 0 3 3 3 0 Centrosome localisation domain of PPC89 Mit_KHE1 PF10173.9 EEA06431.1 - 0.55 10.3 15.8 16 5.5 15.8 2.1 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related HisKA_3 PF07730.13 EEA06431.1 - 0.82 10.2 6.9 1.3 9.6 0.6 3.1 3 1 0 3 3 3 0 Histidine kinase ZnuA PF01297.17 EEA06431.1 - 1 8.7 8.4 2.2 7.6 0.1 2.4 1 1 2 3 3 3 0 Zinc-uptake complex component A periplasmic Serine_rich PF08824.10 EEA06431.1 - 1.1 9.3 7.8 1.4 8.9 2.5 2.4 1 1 0 2 2 2 0 Serine rich protein interaction domain Phage_int_SAM_2 PF12834.7 EEA06431.1 - 1.1 9.9 6.0 1.5 9.6 0.5 2.9 1 1 0 2 2 2 0 Phage integrase, N-terminal Sec20 PF03908.13 EEA06431.1 - 1.4 8.9 9.1 7.9 6.5 2.1 2.9 2 2 1 3 3 3 0 Sec20 DUF2203 PF09969.9 EEA06431.1 - 1.7 9.4 12.5 4.1 8.1 3.3 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF745 PF05335.13 EEA06431.1 - 2 8.1 12.8 3.3 7.4 7.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) ISG65-75 PF11727.8 EEA06431.1 - 2.2 7.5 14.5 0.046 12.9 4.7 2.5 1 1 1 3 3 3 0 Invariant surface glycoprotein T2SSF PF00482.23 EEA06431.1 - 2.3 8.2 8.7 5.6 6.9 2.3 3.0 2 2 0 2 2 2 0 Type II secretion system (T2SS), protein F ABC2_membrane_3 PF12698.7 EEA06431.1 - 2.5 7.1 6.4 36 3.3 6.4 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein Allexi_40kDa PF05549.11 EEA06431.1 - 2.7 7.4 13.7 1.8 8.0 5.5 2.3 1 1 1 2 2 2 0 Allexivirus 40kDa protein ThiF PF00899.21 EEA06433.1 - 5.1e-49 166.8 0.1 7.4e-49 166.3 0.1 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EEA06433.1 - 4e-07 30.5 0.5 1.5e-06 28.6 0.1 2.2 3 0 0 3 3 3 1 Rhodanese-like domain UDPG_MGDP_dh_N PF03721.14 EEA06433.1 - 0.0031 17.1 0.3 0.0064 16.1 0.3 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 EEA06433.1 - 0.048 12.9 0.8 0.07 12.4 0.8 1.2 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 EEA06433.1 - 0.11 12.1 0.1 0.33 10.6 0.1 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EEA06433.1 - 0.11 11.8 0.1 0.21 10.9 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PLDc_2 PF13091.6 EEA06434.1 - 6e-09 35.9 6.4 4.5e-05 23.4 2.2 2.8 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EEA06434.1 - 0.0033 17.5 3.8 0.0084 16.3 0.0 3.4 4 0 0 4 4 4 1 Phospholipase D Active site motif MCM PF00493.23 EEA06435.1 - 1.5e-98 328.4 0.0 3.8e-98 327.1 0.0 1.7 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA06435.1 - 1e-35 122.3 0.1 2.1e-35 121.3 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EEA06435.1 - 1.7e-27 96.6 15.9 1.7e-27 96.6 15.9 2.5 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EEA06435.1 - 6.1e-25 87.5 0.3 1.7e-24 86.0 0.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA06435.1 - 3e-13 50.3 1.8 9.2e-13 48.7 0.4 2.5 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA06435.1 - 5.5e-07 29.2 0.0 3.9e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EEA06435.1 - 0.00011 22.1 0.0 0.00037 20.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA06435.1 - 0.00022 21.3 0.0 0.00075 19.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EEA06435.1 - 0.024 14.3 0.0 0.25 11.1 0.0 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain MBOAT PF03062.19 EEA06436.1 - 4.2e-21 75.7 30.2 8.2e-21 74.7 30.2 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EEA06436.1 - 0.00055 20.2 3.1 0.0019 18.4 3.1 2.0 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family GWT1 PF06423.12 EEA06436.1 - 0.021 15.0 2.2 0.021 15.0 2.2 3.5 4 1 1 5 5 5 0 GWT1 Yos1 PF08571.10 EEA06436.1 - 0.073 13.3 2.0 0.21 11.9 2.0 1.8 1 0 0 1 1 1 0 Yos1-like RPAP3_C PF13877.6 EEA06437.1 - 0.06 13.9 0.1 0.42 11.2 0.1 2.5 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 TIP120 PF08623.10 EEA06437.1 - 0.084 12.6 1.6 6.1 6.6 0.2 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Ribosomal_S25 PF03297.15 EEA06438.1 - 1.7e-36 124.4 2.8 1.9e-36 124.3 2.8 1.0 1 0 0 1 1 1 1 S25 ribosomal protein DUF5531 PF17671.1 EEA06438.1 - 0.033 14.1 0.1 0.04 13.8 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5531) Pkinase PF00069.25 EEA06439.1 - 3e-77 259.6 0.0 5.6e-77 258.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06439.1 - 2.2e-35 122.2 0.0 3.6e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EEA06439.1 - 1.7e-26 89.7 5.7 3.8e-08 32.3 1.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA06439.1 - 7.2e-24 84.0 0.2 8e-11 42.2 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA06439.1 - 1.9e-21 74.1 2.2 0.00013 21.7 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EEA06439.1 - 9.1e-20 69.2 9.0 6.1e-05 22.3 1.9 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EEA06439.1 - 1e-13 50.9 6.4 3.1e-05 23.7 0.3 4.5 3 1 1 4 4 4 3 EF-hand domain pair Pkinase_fungal PF17667.1 EEA06439.1 - 2.8e-05 23.1 0.0 7.9e-05 21.6 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase Dockerin_1 PF00404.18 EEA06439.1 - 4e-05 23.7 0.0 1.7 8.9 0.0 4.0 3 0 0 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 EEA06439.1 - 0.00017 21.5 0.2 0.62 10.0 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand APH PF01636.23 EEA06439.1 - 0.0022 18.0 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA06439.1 - 0.0033 16.8 0.1 0.0066 15.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA06439.1 - 0.0097 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like EF-hand_9 PF14658.6 EEA06439.1 - 0.086 13.2 0.0 0.46 10.9 0.0 2.3 1 1 0 1 1 1 0 EF-hand domain Cyt-b5 PF00173.28 EEA06441.1 - 2e-24 85.5 0.1 3.4e-24 84.8 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Mito_carr PF00153.27 EEA06442.1 - 7.6e-64 211.7 0.0 4.6e-21 74.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PCI PF01399.27 EEA06443.1 - 1.8e-07 31.6 4.6 1.8e-07 31.6 0.5 2.7 2 0 0 2 2 2 1 PCI domain DEAD PF00270.29 EEA06444.1 - 1.5e-46 158.4 0.0 2.7e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06444.1 - 2.8e-30 104.9 0.0 1.3e-29 102.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06444.1 - 0.023 14.7 0.0 0.068 13.2 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA06444.1 - 0.03 13.7 0.0 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 EEA06444.1 - 0.049 12.8 0.1 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase RRM_1 PF00076.22 EEA06445.1 - 1.6e-13 50.3 0.0 2.2e-11 43.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA06445.1 - 0.14 12.3 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif TGT PF01702.18 EEA06446.1 - 3.3e-28 98.9 0.0 5.3e-28 98.2 0.0 1.5 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase RNA_pol_Rpb5_C PF01191.19 EEA06447.1 - 1.5e-34 117.7 0.5 2.7e-34 116.9 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EEA06447.1 - 5.3e-22 78.2 2.5 1e-21 77.3 2.5 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EEA06447.1 - 0.0038 17.2 0.1 0.0081 16.2 0.1 1.5 1 0 0 1 1 1 1 Restriction endonuclease Sld3_N PF18523.1 EEA06447.1 - 0.046 13.8 0.4 0.092 12.9 0.4 1.5 1 0 0 1 1 1 0 Sld3 N-terminal domain Sof1 PF04158.14 EEA06447.1 - 0.047 14.0 0.3 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 Sof1-like domain RC-P840_PscD PF10657.9 EEA06447.1 - 0.077 13.1 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction centre protein PscD Tcp10_C PF07202.13 EEA06449.1 - 0.00046 20.2 0.0 0.00046 20.2 0.0 2.6 2 1 0 2 2 2 1 T-complex protein 10 C-terminus MPS2 PF17060.5 EEA06449.1 - 0.0024 17.2 21.4 0.0037 16.6 21.4 1.3 1 0 0 1 1 1 1 Monopolar spindle protein 2 ERM PF00769.19 EEA06449.1 - 0.0028 17.5 22.1 0.0051 16.7 22.1 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family PPTA PF01239.22 EEA06450.1 - 3.8e-05 23.2 6.0 0.32 10.8 1.5 4.8 4 0 0 4 4 4 2 Protein prenyltransferase alpha subunit repeat NAD_binding_6 PF08030.12 EEA06450.1 - 0.15 12.2 1.4 8.1 6.5 0.1 2.3 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Type2_restr_D3 PF16902.5 EEA06450.1 - 0.48 10.4 4.2 0.61 10.0 0.3 2.8 3 0 0 3 3 3 0 Type-2 restriction enzyme D3 domain Kazal_2 PF07648.15 EEA06451.1 - 6.9e-43 144.5 34.2 4e-11 42.8 4.7 5.5 5 0 0 5 5 5 5 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EEA06451.1 - 1.7e-37 127.2 35.7 9.1e-10 38.4 4.3 5.5 5 0 0 5 5 5 5 Kazal-type serine protease inhibitor domain Membralin PF09746.9 EEA06451.1 - 5.6 5.9 7.2 27 3.6 6.6 2.0 2 0 0 2 2 2 0 Tumour-associated protein Peptidase_M16 PF00675.20 EEA06453.1 - 5.2e-34 117.4 0.2 3.1e-33 114.8 0.0 2.4 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EEA06453.1 - 5.7e-28 98.0 10.0 7.6e-28 97.6 5.5 2.8 2 1 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EEA06453.1 - 2.8e-22 79.6 5.1 1.6e-15 57.6 0.1 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Pkinase PF00069.25 EEA06454.1 - 6.1e-20 71.7 1.7 1e-19 70.9 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EEA06454.1 - 0.11 11.3 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Cpn60_TCP1 PF00118.24 EEA06455.1 - 1.8e-137 458.9 8.0 2.1e-137 458.7 8.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2417 PF10329.9 EEA06456.1 - 0.65 9.4 6.1 1.3 8.4 6.1 1.5 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF3481 PF11980.8 EEA06456.1 - 3.4 7.4 6.6 6.3 6.6 6.6 1.3 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Tetraspanin PF00335.20 EEA06456.1 - 6.2 6.5 10.4 11 5.7 10.4 1.4 1 1 0 1 1 1 0 Tetraspanin family zf-C3HC4_2 PF13923.6 EEA06458.1 - 1.5e-10 40.8 10.4 1.5e-10 40.8 10.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA06458.1 - 1.5e-10 40.7 8.7 1.5e-10 40.7 8.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA06458.1 - 2.7e-09 36.7 10.1 1.3e-08 34.6 10.1 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA06458.1 - 8.2e-09 35.2 8.4 8.2e-09 35.2 8.4 3.1 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EEA06458.1 - 3.9e-07 30.3 11.1 3.9e-07 30.3 11.1 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.6 EEA06458.1 - 8.8e-07 28.7 3.0 3.1e-06 27.0 3.0 1.9 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 EEA06458.1 - 1.2e-06 28.3 11.4 1.2e-06 28.3 11.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA06458.1 - 7.9e-06 25.8 10.8 2.3e-05 24.3 10.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EEA06458.1 - 0.00014 22.0 7.5 0.0005 20.2 7.5 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EEA06458.1 - 0.00026 21.2 7.2 0.00089 19.5 7.2 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-UDP PF14569.6 EEA06458.1 - 0.012 15.7 3.1 0.045 13.9 3.1 2.0 1 0 0 1 1 1 0 Zinc-binding RING-finger SAB PF04382.13 EEA06458.1 - 0.021 14.9 0.2 0.094 12.8 0.2 2.1 1 0 0 1 1 1 0 SAB domain KRTDAP PF15200.6 EEA06458.1 - 0.063 13.1 0.4 0.28 11.0 0.4 2.1 1 0 0 1 1 1 0 Keratinocyte differentiation-associated zf-C3HC4_5 PF17121.5 EEA06458.1 - 0.066 13.1 4.7 0.31 10.9 4.7 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Siva PF05458.12 EEA06458.1 - 0.26 11.0 5.1 0.25 11.0 0.6 2.3 2 0 0 2 2 2 0 Cd27 binding protein (Siva) zf-ANAPC11 PF12861.7 EEA06458.1 - 0.42 10.7 4.6 0.92 9.6 4.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EEA06458.1 - 0.44 10.3 7.1 1.2 9.0 7.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EEA06458.1 - 4.9 6.9 10.9 1.1 8.9 7.0 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Ccdc124 PF06244.12 EEA06459.1 - 5.8e-29 101.2 24.7 6.8e-26 91.3 24.7 2.5 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 EEA06459.1 - 0.0001 22.6 1.0 0.0001 22.6 1.0 2.8 3 1 0 3 3 3 1 HMG (high mobility group) box DUF5108 PF17133.4 EEA06459.1 - 0.12 12.4 0.1 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5108) LAP1C PF05609.12 EEA06459.1 - 0.13 11.4 7.8 0.16 11.0 7.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DMA PF03474.14 EEA06459.1 - 0.19 11.4 0.1 0.42 10.2 0.1 1.6 1 0 0 1 1 1 0 DMRTA motif Trans_reg_C PF00486.28 EEA06459.1 - 0.22 11.7 1.7 0.58 10.3 0.0 2.4 3 0 0 3 3 3 0 Transcriptional regulatory protein, C terminal Hydin_ADK PF17213.3 EEA06459.1 - 0.56 10.5 4.6 0.74 10.1 4.6 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain LMBR1 PF04791.16 EEA06459.1 - 2.8 6.7 5.0 2.9 6.7 5.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Proteasome PF00227.26 EEA06460.1 - 2.6e-46 157.5 1.1 2.9e-46 157.4 1.1 1.0 1 0 0 1 1 1 1 Proteasome subunit P5CR_dimer PF14748.6 EEA06460.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation PIG-P PF08510.12 EEA06462.1 - 5.4e-27 94.1 0.2 3e-26 91.7 0.2 1.8 1 1 0 1 1 1 1 PIG-P SieB PF14163.6 EEA06462.1 - 0.51 9.8 3.7 0.88 9.1 3.7 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B DUF846 PF05832.12 EEA06463.1 - 6.1e-42 143.0 20.1 7.9e-42 142.6 20.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) UPF0242 PF06785.11 EEA06463.1 - 1.1 9.3 3.2 2.1 8.4 3.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4149 PF13664.6 EEA06463.1 - 1.9 8.9 8.3 6.2 7.2 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) RseC_MucC PF04246.12 EEA06463.1 - 2.7 7.9 4.1 27 4.7 1.1 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC SUI1 PF01253.22 EEA06464.1 - 2e-25 89.1 0.2 2.6e-25 88.7 0.2 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 EEA06464.1 - 0.022 15.0 0.0 0.033 14.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) EF-hand_1 PF00036.32 EEA06466.1 - 7.8e-39 128.3 10.8 3.6e-09 35.5 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA06466.1 - 3.6e-33 113.8 3.1 1.5e-16 60.6 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA06466.1 - 6.6e-30 102.7 12.4 1.2e-14 53.8 1.1 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EEA06466.1 - 6.7e-29 97.3 6.2 2.9e-09 36.1 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EEA06466.1 - 7.1e-24 82.2 8.8 4.1e-06 26.0 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EEA06466.1 - 5.3e-13 49.1 0.1 3.6e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA06466.1 - 3.4e-08 33.4 0.6 0.0012 18.8 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EEA06466.1 - 2.7e-07 30.9 0.2 0.0088 16.4 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 EEA06466.1 - 1.1e-05 26.2 0.0 0.0012 19.7 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 EEA06466.1 - 0.00031 20.7 0.0 0.31 11.1 0.0 2.6 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) DUF3349 PF11829.8 EEA06466.1 - 0.0016 19.2 0.3 1.8 9.4 0.0 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 EEA06466.1 - 0.0017 18.3 0.2 0.74 9.7 0.0 3.0 1 1 2 3 3 3 1 Caleosin related protein Dockerin_1 PF00404.18 EEA06466.1 - 0.0023 18.1 4.4 0.14 12.4 0.3 3.1 1 1 3 4 4 4 1 Dockerin type I domain MotA_activ PF09114.10 EEA06466.1 - 0.0051 16.9 0.0 0.063 13.4 0.0 2.1 2 0 0 2 2 2 1 Transcription factor MotA, activation domain TerB PF05099.13 EEA06466.1 - 0.022 14.7 0.2 1.9 8.4 0.0 2.3 1 1 1 2 2 2 0 Tellurite resistance protein TerB EFhand_Ca_insen PF08726.10 EEA06466.1 - 0.033 14.3 0.5 0.098 12.8 0.1 2.1 2 1 0 2 2 2 0 Ca2+ insensitive EF hand DUF1103 PF06513.11 EEA06466.1 - 0.042 13.4 0.5 0.048 13.3 0.5 1.2 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Poly_export PF02563.16 EEA06466.1 - 0.043 14.1 0.0 2.2 8.6 0.0 2.9 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein RNA_pol_Rpb4 PF03874.16 EEA06466.1 - 0.051 13.9 1.1 1.6 9.1 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 DUF1811 PF08838.10 EEA06466.1 - 0.096 12.9 0.0 22 5.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) RloB PF13707.6 EEA06466.1 - 0.14 12.3 0.2 1.6 8.9 0.0 2.0 1 1 0 2 2 2 0 RloB-like protein SapB_1 PF05184.15 EEA06466.1 - 0.39 10.8 3.0 6.8 6.8 0.0 3.4 4 0 0 4 4 4 0 Saposin-like type B, region 1 MFS_1 PF07690.16 EEA06467.1 - 3.2e-18 65.8 39.8 8.5e-17 61.1 37.8 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily LCCL PF03815.19 EEA06468.1 - 1.2e-82 272.1 10.9 2.1e-22 79.1 0.5 4.9 5 0 0 5 5 5 4 LCCL domain SRCR PF00530.18 EEA06468.1 - 1.5e-32 112.1 7.5 2.9e-18 66.2 2.3 2.7 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Laminin_G_3 PF13385.6 EEA06468.1 - 1.9e-18 67.1 0.3 6.7e-18 65.3 0.3 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PLAT PF01477.23 EEA06468.1 - 1.7e-11 44.7 0.3 5.7e-08 33.3 0.1 2.8 3 0 0 3 3 3 2 PLAT/LH2 domain Rxt3 PF08642.10 EEA06468.1 - 1.4e-09 38.8 0.2 0.0031 18.3 0.1 3.8 3 1 1 4 4 4 3 Histone deacetylation protein Rxt3 Pentaxin PF00354.17 EEA06468.1 - 5.2e-06 26.3 0.1 9.9e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Pentaxin family SRCR_2 PF15494.6 EEA06468.1 - 5.4e-05 23.6 2.0 0.00075 20.0 0.4 2.6 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Bac_surface_Ag PF01103.23 EEA06470.1 - 1.5e-18 67.4 4.8 3.5e-18 66.2 4.8 1.5 1 1 0 1 1 1 1 Surface antigen DUF5107 PF17128.4 EEA06470.1 - 0.069 12.3 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5107) SNAP PF14938.6 EEA06471.1 - 1.9e-61 208.0 14.3 5.4e-59 199.9 14.3 2.8 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EEA06471.1 - 1.1e-06 28.8 1.2 0.023 15.0 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat Sel1 PF08238.12 EEA06471.1 - 8.1e-06 26.4 1.5 1.6 9.5 0.0 4.5 5 0 0 5 5 5 2 Sel1 repeat TPR_2 PF07719.17 EEA06471.1 - 0.00044 20.1 12.6 3.7 7.9 0.5 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat DHR-2 PF06920.13 EEA06471.1 - 0.0022 16.7 1.3 0.0022 16.7 1.3 1.7 2 0 0 2 2 2 1 Dock homology region 2 TPR_8 PF13181.6 EEA06471.1 - 0.0027 17.8 15.6 1.5 9.3 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA06471.1 - 0.01 15.6 16.9 5.3 7.0 0.0 6.2 5 1 1 6 6 6 0 Tetratricopeptide repeat NSF PF02071.20 EEA06471.1 - 0.13 13.1 14.7 20 6.6 0.1 6.1 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_7 PF13176.6 EEA06471.1 - 1.4 9.1 12.6 21 5.5 0.2 5.6 6 1 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 EEA06471.1 - 6.9 6.8 20.1 2.1 8.5 0.2 5.7 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain WD40 PF00400.32 EEA06472.1 - 5.2e-09 36.6 11.6 0.0088 16.9 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat CPSF_A PF03178.15 EEA06472.1 - 0.00036 20.0 0.1 0.00061 19.2 0.1 1.4 1 0 0 1 1 1 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 EEA06472.1 - 0.00063 20.0 0.1 4.5 7.7 0.1 4.1 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Spermine_synth PF01564.17 EEA06472.1 - 0.083 12.3 0.2 4.3 6.7 0.0 2.4 2 0 0 2 2 2 0 Spermine/spermidine synthase domain Dynein_light PF01221.18 EEA06473.1 - 6.3e-42 141.8 0.7 7e-42 141.7 0.7 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Tau95 PF09734.9 EEA06474.1 - 4.9e-28 98.7 0.6 1.1e-27 97.5 0.6 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EEA06474.1 - 2.8e-12 46.9 0.1 6.7e-09 36.0 0.1 2.6 1 1 0 1 1 1 1 Tau95 Triple barrel domain Vps5 PF09325.10 EEA06475.1 - 0.00034 20.2 3.7 0.00034 20.2 3.7 1.8 2 0 0 2 2 2 1 Vps5 C terminal like BUD22 PF09073.10 EEA06475.1 - 0.0013 18.2 12.5 0.002 17.6 12.5 1.2 1 0 0 1 1 1 1 BUD22 Presenilin PF01080.17 EEA06475.1 - 0.39 9.4 16.8 0.65 8.7 16.8 1.4 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 EEA06475.1 - 0.6 9.7 31.1 1.1 8.8 31.1 1.5 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 EEA06475.1 - 1.4 7.5 18.5 2.1 7.0 18.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.22 EEA06475.1 - 2.6 7.2 6.7 3.4 6.8 6.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_C97 PF05903.14 EEA06476.1 - 1.8e-31 109.0 0.0 2.6e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF1966 PF09260.11 EEA06476.1 - 0.067 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1966) MutL_C PF08676.11 EEA06477.1 - 1.2e-21 77.0 0.3 3.4e-19 69.1 0.2 2.7 2 0 0 2 2 2 2 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EEA06477.1 - 7.1e-17 61.2 0.1 2.2e-16 59.6 0.1 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EEA06477.1 - 9.5e-09 35.2 1.1 3.6e-08 33.3 1.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EEA06477.1 - 0.0071 16.8 0.8 0.016 15.7 0.8 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Phage_Coat_A PF05357.13 EEA06478.1 - 0.011 15.4 0.3 0.042 13.6 0.3 2.0 1 0 0 1 1 1 0 Phage Coat Protein A zf-RING_5 PF14634.6 EEA06478.1 - 0.021 14.8 9.8 0.12 12.4 9.8 2.2 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA06478.1 - 0.055 13.3 6.5 0.089 12.7 2.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA06478.1 - 0.066 13.2 8.6 0.044 13.8 2.7 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA06478.1 - 0.067 13.1 8.6 0.12 12.3 5.2 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA06478.1 - 0.33 11.1 7.8 0.69 10.1 3.6 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EEA06478.1 - 0.91 9.9 8.2 2.3 8.6 3.9 2.7 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 EEA06478.1 - 2.5 8.0 7.9 4.4 7.2 4.3 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPR_MLP1_2 PF07926.12 EEA06479.1 - 0.00048 20.2 20.4 0.00048 20.2 20.4 15.8 6 5 9 15 15 15 5 TPR/MLP1/MLP2-like protein IMPa_helical PF18642.1 EEA06479.1 - 2 8.9 25.7 4.1 7.9 0.2 7.6 7 1 0 7 7 7 0 Immunomodulating metalloprotease helical domain YqzM PF14141.6 EEA06480.1 - 0.81 9.8 4.8 0.31 11.1 0.4 2.6 2 0 0 2 2 2 0 YqzM-like protein PHO4 PF01384.20 EEA06480.1 - 3.2 6.7 5.6 7.4 5.5 5.6 1.7 1 1 0 1 1 1 0 Phosphate transporter family Sad1_UNC PF07738.13 EEA06482.1 - 6.7e-14 52.0 0.8 6.7e-14 52.0 0.8 3.3 3 1 0 3 3 3 1 Sad1 / UNC-like C-terminal DUF1664 PF07889.12 EEA06482.1 - 4.9 7.2 9.4 3.8 7.6 4.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF5414 PF17435.2 EEA06483.1 - 0.056 13.1 0.7 0.083 12.5 0.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5414) DUF1993 PF09351.10 EEA06483.1 - 0.11 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) IRK_C PF17655.1 EEA06484.1 - 5.2e-11 42.5 0.0 8.3e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 EEA06484.1 - 7.4e-06 25.8 10.8 3.6e-05 23.6 10.8 2.0 1 1 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 EEA06484.1 - 0.12 12.4 10.2 0.045 13.7 7.2 1.9 2 0 0 2 2 2 0 Ion channel Sec61_beta PF03911.16 EEA06485.1 - 1.1e-14 54.1 0.9 1.3e-14 53.9 0.9 1.1 1 0 0 1 1 1 1 Sec61beta family ICAT PF06384.11 EEA06486.1 - 0.039 14.2 2.2 3 8.2 0.1 2.8 2 1 0 2 2 2 0 Beta-catenin-interacting protein ICAT Cpn60_TCP1 PF00118.24 EEA06487.1 - 3.2e-145 484.5 4.3 3.7e-145 484.3 4.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nuc_sug_transp PF04142.15 EEA06488.1 - 1.3e-99 333.3 24.3 1.6e-99 333.1 24.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter DUF1240 PF06836.12 EEA06488.1 - 7.5 7.2 10.3 14 6.3 2.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1240) EamA PF00892.20 EEA06488.1 - 8.4 6.6 32.7 2.8 8.1 13.2 3.5 2 2 0 2 2 2 0 EamA-like transporter family SpoU_methylase PF00588.19 EEA06490.1 - 1.1e-26 93.7 0.0 1.4e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family Mon2_C PF16206.5 EEA06491.1 - 3e-11 42.2 7.1 2.3e-08 32.7 0.0 4.3 5 0 0 5 5 5 3 C-terminal region of Mon2 protein PQ-loop PF04193.14 EEA06493.1 - 1e-15 57.2 29.1 9.4e-10 38.1 11.4 3.0 3 0 0 3 3 3 2 PQ loop repeat Solute_trans_a PF03619.16 EEA06494.1 - 1.5e-08 34.5 18.6 2.4e-08 33.9 18.6 1.3 1 0 0 1 1 1 1 Organic solute transporter Ostalpha CcmD PF04995.14 EEA06494.1 - 0.032 14.3 0.3 0.12 12.5 0.3 1.9 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Proteasome PF00227.26 EEA06495.1 - 5.7e-36 123.8 0.0 6.4e-36 123.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Poxvirus PF06227.12 EEA06495.1 - 0.072 12.9 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 dsDNA Poxvirus Mito_carr PF00153.27 EEA06496.1 - 1.4e-33 114.7 2.4 4.1e-15 55.5 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein TBPIP PF07106.13 EEA06497.1 - 8.4e-23 80.1 3.0 2.5e-22 78.6 3.0 1.9 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain WXG100 PF06013.12 EEA06497.1 - 0.0032 17.7 2.2 0.13 12.5 0.1 2.8 3 0 0 3 3 3 1 Proteins of 100 residues with WXG DASH_Dad1 PF08649.10 EEA06497.1 - 0.025 14.8 5.8 0.35 11.1 0.2 2.8 2 0 0 2 2 2 0 DASH complex subunit Dad1 CENP-F_leu_zip PF10473.9 EEA06497.1 - 0.043 13.8 14.1 0.081 12.9 13.2 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SKA2 PF16740.5 EEA06497.1 - 0.06 13.1 0.6 0.06 13.1 0.6 3.1 4 0 0 4 4 4 0 Spindle and kinetochore-associated protein 2 Uds1 PF15456.6 EEA06497.1 - 0.45 10.7 8.0 3.1 8.0 0.6 3.3 3 0 0 3 3 3 0 Up-regulated During Septation DUF4140 PF13600.6 EEA06497.1 - 0.8 10.2 3.4 6.3 7.3 0.5 2.7 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) TipAS PF07739.13 EEA06497.1 - 0.95 10.0 7.5 8.8 6.9 0.8 3.2 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain Jnk-SapK_ap_N PF09744.9 EEA06497.1 - 1 9.5 15.3 0.14 12.4 5.3 2.8 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF3450 PF11932.8 EEA06497.1 - 1.1 8.5 13.1 0.28 10.5 4.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) bZIP_1 PF00170.21 EEA06497.1 - 1.9 8.6 18.0 0.39 10.9 3.7 4.1 4 0 0 4 4 4 0 bZIP transcription factor K-box PF01486.17 EEA06497.1 - 3.7 7.8 15.5 11 6.2 3.3 3.4 2 1 0 3 3 3 0 K-box region CENP-H PF05837.12 EEA06497.1 - 4.4 7.7 15.6 0.58 10.6 6.3 3.1 1 1 1 3 3 3 0 Centromere protein H (CENP-H) DUF465 PF04325.13 EEA06497.1 - 6.6 6.8 10.8 3.3 7.8 2.6 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF465) DivIC PF04977.15 EEA06497.1 - 8.7 6.2 18.0 0.85 9.4 5.2 3.7 2 2 2 4 4 4 0 Septum formation initiator BRCT_2 PF16589.5 EEA06498.1 - 0.0027 18.1 1.2 0.23 11.9 0.1 3.3 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain EcsC PF12787.7 EEA06498.1 - 0.095 12.4 0.0 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 EcsC protein family SGP PF17228.2 EEA06499.1 - 8.7 7.3 24.1 2.8 8.9 18.2 2.4 2 0 0 2 2 2 0 Sulphur globule protein Porin_3 PF01459.22 EEA06501.1 - 0.002 17.6 10.6 0.0077 15.7 10.6 2.1 1 1 0 1 1 1 1 Eukaryotic porin Big_3_5 PF16640.5 EEA06501.1 - 0.065 13.4 0.0 0.065 13.4 0.0 2.8 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 3) HSP70 PF00012.20 EEA06503.1 - 1.7e-261 868.7 6.2 1.9e-261 868.5 6.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA06503.1 - 1.6e-15 56.8 1.2 3.9e-14 52.2 0.0 2.4 3 0 0 3 3 3 1 MreB/Mbl protein FtsA PF14450.6 EEA06503.1 - 0.0033 17.8 1.6 5.9 7.4 0.0 3.5 3 1 0 3 3 3 1 Cell division protein FtsA DDR PF08841.10 EEA06503.1 - 0.013 14.5 0.8 0.23 10.4 0.3 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain MutS_III PF05192.18 EEA06503.1 - 0.014 15.6 4.1 3.9 7.7 0.0 2.3 2 0 0 2 2 2 0 MutS domain III FGGY_C PF02782.16 EEA06503.1 - 0.02 14.6 0.0 0.11 12.3 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Thioredox_DsbH PF03190.15 EEA06503.1 - 0.18 11.8 0.8 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF255 Hydantoinase_A PF01968.18 EEA06503.1 - 0.22 10.8 3.6 0.082 12.2 0.2 2.1 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase DUF2115 PF09888.9 EEA06503.1 - 0.3 11.6 2.6 0.39 11.2 1.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Golgin_A5 PF09787.9 EEA06503.1 - 0.34 10.3 11.5 0.73 9.2 11.5 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 Aminotran_5 PF00266.19 EEA06504.1 - 3.1e-32 112.0 0.0 2e-24 86.2 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V zf-GRF PF06839.12 EEA06505.1 - 3.2e-10 39.9 4.8 3.2e-10 39.9 4.8 2.1 2 0 0 2 2 2 1 GRF zinc finger Exo_endo_phos PF03372.23 EEA06505.1 - 1.9e-08 34.1 0.0 1.7e-07 31.0 0.0 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EEA06505.1 - 9.1e-07 28.7 0.0 0.0041 17.0 0.0 2.6 1 1 0 2 2 2 2 Endonuclease-reverse transcriptase TA0956 PF11513.8 EEA06505.1 - 0.063 13.5 0.1 0.21 11.8 0.1 1.9 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 Nop PF01798.18 EEA06506.1 - 7.8e-85 284.0 0.5 7.8e-85 284.0 0.5 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EEA06506.1 - 2e-16 60.1 0.0 7.4e-16 58.3 0.0 2.1 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Duffy_binding PF05424.11 EEA06506.1 - 0.061 13.4 4.0 0.14 12.2 4.0 1.6 1 0 0 1 1 1 0 Duffy binding domain ABC_tran PF00005.27 EEA06507.1 - 2.1e-29 102.8 0.0 1.1e-19 71.2 0.0 3.4 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA06507.1 - 1.7e-14 54.1 35.5 8.8e-13 48.5 15.9 3.0 3 1 1 4 4 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA06507.1 - 1.8e-05 24.3 1.8 0.055 12.9 0.0 3.6 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 EEA06507.1 - 3.2e-05 23.1 0.0 0.16 11.0 0.0 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.6 EEA06507.1 - 6e-05 23.3 0.0 0.16 12.3 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 EEA06507.1 - 0.00012 22.5 0.0 0.081 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EEA06507.1 - 0.00027 20.6 0.1 0.023 14.4 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EEA06507.1 - 0.00032 20.7 0.4 0.16 11.9 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_25 PF13481.6 EEA06507.1 - 0.00045 19.8 0.0 0.065 12.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EEA06507.1 - 0.00054 19.9 0.2 0.023 14.6 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EEA06507.1 - 0.001 19.6 0.0 1.6 9.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EEA06507.1 - 0.0014 18.4 0.0 0.42 10.3 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 EEA06507.1 - 0.0019 18.7 5.9 0.34 11.4 0.5 2.8 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EEA06507.1 - 0.0023 18.0 0.1 0.026 14.6 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 EEA06507.1 - 0.0037 16.9 0.1 1.4 8.5 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EEA06507.1 - 0.0046 16.2 0.1 2.8 7.1 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain RNA_helicase PF00910.22 EEA06507.1 - 0.0047 17.3 0.0 0.33 11.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 EEA06507.1 - 0.0053 16.3 0.0 0.85 9.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 EEA06507.1 - 0.0055 16.7 0.0 0.49 10.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EEA06507.1 - 0.0055 16.4 0.0 1.2 8.8 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.6 EEA06507.1 - 0.0065 16.8 0.0 0.14 12.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EEA06507.1 - 0.011 15.6 0.1 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_11 PF13086.6 EEA06507.1 - 0.012 15.4 0.0 0.041 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EEA06507.1 - 0.012 15.6 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA06507.1 - 0.014 15.2 0.0 0.62 9.8 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_21 PF13304.6 EEA06507.1 - 0.017 14.9 5.3 0.095 12.5 0.2 4.0 5 0 0 5 5 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EEA06507.1 - 0.021 14.7 0.1 0.15 11.9 0.0 2.4 2 1 0 2 2 2 0 Rad17 P-loop domain AAA_33 PF13671.6 EEA06507.1 - 0.038 14.2 0.0 3 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EEA06507.1 - 0.046 14.2 0.0 0.49 10.8 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EEA06507.1 - 0.054 12.8 2.7 0.2 11.0 0.0 2.8 3 0 0 3 3 3 0 KaiC DUF87 PF01935.17 EEA06507.1 - 0.06 13.4 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain PhoH PF02562.16 EEA06507.1 - 0.062 12.7 0.0 0.83 9.1 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein RsgA_GTPase PF03193.16 EEA06507.1 - 0.081 12.8 0.1 1.9 8.4 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EEA06507.1 - 0.086 12.6 0.2 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA06507.1 - 0.096 12.0 0.1 1.7 7.9 0.1 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EEA06508.1 - 7.7e-33 113.9 0.0 2.8e-16 60.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA06508.1 - 4.4e-15 56.1 31.9 7.6e-14 52.0 11.2 2.7 3 0 0 3 3 2 2 ABC transporter transmembrane region MMR_HSR1 PF01926.23 EEA06508.1 - 2.8e-07 30.6 0.1 0.031 14.4 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EEA06508.1 - 3.2e-06 26.8 0.6 0.062 13.1 0.1 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA06508.1 - 8.1e-06 26.3 0.0 0.00075 19.9 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EEA06508.1 - 0.00021 21.2 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EEA06508.1 - 0.00034 20.9 0.1 0.14 12.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EEA06508.1 - 0.00035 19.8 0.0 0.017 14.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EEA06508.1 - 0.00052 19.6 0.0 0.39 10.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF87 PF01935.17 EEA06508.1 - 0.0013 18.9 0.3 0.01 15.9 0.2 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EEA06508.1 - 0.0013 18.1 0.6 0.0032 16.8 0.1 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_23 PF13476.6 EEA06508.1 - 0.0014 19.1 1.1 0.33 11.4 0.2 2.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA06508.1 - 0.0016 18.5 0.1 0.2 11.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EEA06508.1 - 0.0018 18.6 0.2 0.62 10.5 0.0 3.2 3 0 0 3 3 2 1 RNA helicase SMC_N PF02463.19 EEA06508.1 - 0.002 17.6 0.3 3.8 6.9 0.1 3.4 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EEA06508.1 - 0.0031 16.6 0.1 0.15 11.0 0.1 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EEA06508.1 - 0.0036 17.4 1.2 0.86 9.6 0.2 2.9 3 0 0 3 3 2 1 Dynamin family AAA_21 PF13304.6 EEA06508.1 - 0.0042 16.9 0.4 0.39 10.5 0.3 3.0 4 0 0 4 4 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Viral_helicase1 PF01443.18 EEA06508.1 - 0.0044 16.8 0.0 0.36 10.5 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EEA06508.1 - 0.0049 16.2 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA PF00004.29 EEA06508.1 - 0.0052 17.2 0.3 0.02 15.3 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EEA06508.1 - 0.0076 15.3 0.0 0.035 13.2 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein NACHT PF05729.12 EEA06508.1 - 0.0077 16.2 0.1 1.2 9.0 0.0 2.6 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 EEA06508.1 - 0.015 14.5 0.1 2.3 7.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 EEA06508.1 - 0.016 15.1 0.1 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 EEA06508.1 - 0.019 14.4 0.0 6.2 6.1 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EEA06508.1 - 0.025 14.3 0.0 3.7 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EEA06508.1 - 0.029 14.5 0.2 6.7 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EEA06508.1 - 0.046 13.4 0.0 4.7 6.9 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Ploopntkinase3 PF18751.1 EEA06508.1 - 0.066 13.1 0.0 3.5 7.5 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 ATPase_2 PF01637.18 EEA06508.1 - 0.086 12.7 0.2 14 5.5 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea TsaE PF02367.17 EEA06508.1 - 0.087 12.8 0.0 6.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EEA06508.1 - 0.11 12.7 0.1 3.6 7.8 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EEA06508.1 - 0.14 12.7 0.2 22 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EEA06508.1 - 0.2 11.3 0.0 13 5.4 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_15 PF13175.6 EEA06508.1 - 0.2 11.3 6.6 1.3 8.6 0.0 3.0 4 0 0 4 4 3 0 AAA ATPase domain ABC_tran PF00005.27 EEA06509.1 - 2.4e-33 115.6 0.0 4.1e-17 63.0 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EEA06509.1 - 1.5e-08 34.3 0.4 0.0047 16.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA06509.1 - 1e-06 29.4 11.1 0.0041 17.7 0.3 3.7 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EEA06509.1 - 5.8e-06 26.4 0.9 0.0023 18.0 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EEA06509.1 - 0.00013 21.4 0.0 0.3 10.4 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 EEA06509.1 - 0.00018 21.4 0.1 0.39 10.6 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EEA06509.1 - 0.001 19.5 0.0 0.5 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 EEA06509.1 - 0.0015 17.7 0.6 0.39 9.9 0.1 2.5 2 0 0 2 2 2 1 NB-ARC domain T2SSE PF00437.20 EEA06509.1 - 0.0038 16.3 0.2 1.3 8.0 0.1 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein SMC_N PF02463.19 EEA06509.1 - 0.0047 16.4 3.8 0.83 9.0 0.2 3.6 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 EEA06509.1 - 0.0047 16.9 1.3 0.2 11.5 0.1 2.6 2 0 0 2 2 2 1 NTPase Dynamin_N PF00350.23 EEA06509.1 - 0.005 16.9 0.4 0.2 11.7 0.1 2.9 2 0 0 2 2 2 1 Dynamin family Roc PF08477.13 EEA06509.1 - 0.0056 16.9 0.6 0.38 11.0 0.1 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EEA06509.1 - 0.006 16.4 0.5 1.3 8.7 0.1 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein NACHT PF05729.12 EEA06509.1 - 0.0074 16.2 3.9 0.42 10.5 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 EEA06509.1 - 0.0079 16.5 1.0 8.5 6.6 0.1 3.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 EEA06509.1 - 0.018 15.0 0.0 0.53 10.3 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EEA06509.1 - 0.019 14.5 0.4 0.91 9.0 0.1 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 EEA06509.1 - 0.025 14.7 0.1 2.1 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA06509.1 - 0.029 14.9 0.1 5 7.7 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EEA06509.1 - 0.03 14.0 1.1 0.43 10.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EEA06509.1 - 0.059 13.2 19.1 0.07 12.9 0.5 4.7 5 1 0 6 6 5 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 EEA06509.1 - 0.059 13.0 0.3 0.86 9.2 0.0 2.6 2 1 1 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 EEA06509.1 - 0.064 12.4 0.1 1.7 7.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_30 PF13604.6 EEA06509.1 - 0.065 13.0 0.0 15 5.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EEA06509.1 - 0.11 12.2 2.3 12 5.6 0.1 3.4 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 EEA06509.1 - 0.12 12.5 3.9 1.1 9.3 0.6 2.8 2 0 0 2 2 2 0 Helicase HerA, central domain AAA PF00004.29 EEA06509.1 - 0.16 12.4 0.3 3.9 7.9 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EEA06509.1 - 0.23 11.0 1.1 16 5.0 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 EEA06509.1 - 0.24 10.2 0.4 5.4 5.8 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MobB PF03205.14 EEA06509.1 - 0.27 11.1 0.8 7 6.6 0.1 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 EEA06509.1 - 1.2 9.0 10.4 2.1 8.2 0.3 3.5 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EEA06510.1 - 1.3e-36 126.1 0.0 5.2e-17 62.7 0.0 3.7 4 0 0 4 4 3 2 ABC transporter ABC_membrane PF00664.23 EEA06510.1 - 7.5e-27 94.7 32.0 4.2e-18 66.0 9.3 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region MMR_HSR1 PF01926.23 EEA06510.1 - 8.6e-07 29.0 0.5 0.02 15.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 EEA06510.1 - 9e-07 28.2 0.1 0.025 13.6 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EEA06510.1 - 8.8e-06 25.3 0.3 0.012 15.0 0.1 2.6 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_16 PF13191.6 EEA06510.1 - 1e-05 26.0 0.1 0.002 18.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EEA06510.1 - 1.4e-05 25.0 0.1 0.051 13.5 0.0 2.8 3 0 0 3 3 2 2 NACHT domain AAA_29 PF13555.6 EEA06510.1 - 3.5e-05 23.4 0.8 0.27 11.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EEA06510.1 - 4.3e-05 23.1 0.0 1.2 8.5 0.0 4.1 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 EEA06510.1 - 4.6e-05 23.6 13.4 0.0033 17.5 0.1 4.5 4 0 0 4 4 4 2 Helicase HerA, central domain AAA_22 PF13401.6 EEA06510.1 - 0.00015 22.1 0.0 0.2 11.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EEA06510.1 - 0.00057 19.8 0.4 0.13 12.2 0.1 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 EEA06510.1 - 0.0008 19.2 0.1 0.15 11.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EEA06510.1 - 0.00086 19.4 7.6 0.26 11.3 0.2 3.5 3 0 0 3 3 2 2 Dynamin family Viral_helicase1 PF01443.18 EEA06510.1 - 0.0009 19.0 0.0 0.97 9.1 0.0 2.6 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EEA06510.1 - 0.0015 17.8 0.0 0.012 14.9 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin TrwB_AAD_bind PF10412.9 EEA06510.1 - 0.0016 17.4 0.8 0.4 9.5 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 EEA06510.1 - 0.0022 17.6 0.3 0.59 9.6 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region cobW PF02492.19 EEA06510.1 - 0.0024 17.5 1.3 0.059 13.0 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 EEA06510.1 - 0.0031 17.9 0.7 0.11 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EEA06510.1 - 0.0052 16.6 0.5 2.9 7.6 0.1 2.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 EEA06510.1 - 0.0057 17.0 0.9 0.55 10.6 0.0 3.3 3 0 0 3 3 2 1 RNA helicase NTPase_1 PF03266.15 EEA06510.1 - 0.008 16.1 0.3 1.7 8.5 0.0 2.6 2 0 0 2 2 2 1 NTPase AAA_33 PF13671.6 EEA06510.1 - 0.0087 16.2 0.0 1.9 8.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.16 EEA06510.1 - 0.0088 15.4 1.1 2.3 7.5 0.0 2.8 2 0 0 2 2 2 1 AIG1 family AAA_18 PF13238.6 EEA06510.1 - 0.0094 16.5 1.2 2.1 8.9 0.0 3.9 3 0 0 3 3 2 1 AAA domain Roc PF08477.13 EEA06510.1 - 0.017 15.4 0.3 0.45 10.7 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EEA06510.1 - 0.017 14.9 0.1 1.6 8.5 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EEA06510.1 - 0.018 14.4 0.0 5 6.4 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 EEA06510.1 - 0.02 14.1 1.1 4.5 6.4 0.1 2.7 2 0 0 2 2 2 0 NB-ARC domain MeaB PF03308.16 EEA06510.1 - 0.03 13.3 0.2 0.91 8.4 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EEA06510.1 - 0.048 13.4 0.2 3.4 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EEA06510.1 - 0.085 12.4 0.0 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EEA06510.1 - 0.12 12.9 1.2 0.37 11.2 0.0 2.5 3 0 0 3 3 1 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 EEA06510.1 - 0.22 11.4 1.5 7.6 6.4 0.0 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 EEA06510.1 - 0.26 11.5 0.6 0.61 10.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain EMC3_TMCO1 PF01956.16 EEA06510.1 - 0.39 10.4 9.7 0.41 10.4 1.5 3.4 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Mod_r PF07200.13 EEA06511.1 - 0.031 14.4 4.7 0.12 12.5 3.6 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Apc13p PF05839.11 EEA06511.1 - 0.058 13.6 2.5 2.9 8.2 0.1 2.4 2 0 0 2 2 2 0 Apc13p protein DUF4041 PF13250.6 EEA06511.1 - 1.6 8.6 14.8 9 6.3 0.2 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4041) DEAD PF00270.29 EEA06512.1 - 1.4e-34 119.4 0.0 4.1e-34 117.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06512.1 - 7.9e-24 84.1 4.6 1.9e-21 76.5 2.7 3.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06512.1 - 4.5e-12 46.3 0.0 4.5e-12 46.3 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EEA06512.1 - 0.12 12.7 0.0 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ribosomal_L29e PF01779.17 EEA06513.1 - 5.6e-21 74.6 9.0 7.4e-21 74.2 9.0 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Ribosomal_60s PF00428.19 EEA06514.1 - 5.2e-13 49.4 0.0 6.2e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein R3H PF01424.22 EEA06515.1 - 0.015 15.2 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 R3H domain R3H-assoc PF13902.6 EEA06515.1 - 0.016 15.6 0.8 0.022 15.1 0.1 1.5 2 0 0 2 2 2 0 R3H-associated N-terminal domain Integrase_DNA PF02920.15 EEA06515.1 - 0.26 11.0 4.7 0.8 9.5 1.4 2.6 1 1 1 2 2 2 0 DNA binding domain of tn916 integrase Brix PF04427.18 EEA06516.1 - 4.3e-30 105.2 0.6 7e-30 104.6 0.6 1.3 1 0 0 1 1 1 1 Brix domain Ribosomal_S24e PF01282.19 EEA06517.1 - 1.5e-29 101.8 0.0 2.5e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e IF-2 PF11987.8 EEA06517.1 - 0.15 12.2 0.2 0.48 10.6 0.0 1.8 2 0 0 2 2 2 0 Translation-initiation factor 2 BCAS2 PF05700.11 EEA06518.1 - 6.9e-11 42.2 2.4 4e-10 39.7 2.4 1.9 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Peptidase_S7 PF00949.21 EEA06518.1 - 0.085 12.7 5.8 5.4 6.9 5.8 2.2 1 1 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Got1 PF04178.12 EEA06519.1 - 1.1e-14 54.8 14.0 1.4e-14 54.5 14.0 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF308 PF03729.13 EEA06519.1 - 0.007 16.7 7.3 0.007 16.7 7.3 2.2 1 1 1 2 2 2 1 Short repeat of unknown function (DUF308) NPL PF17800.1 EEA06520.1 - 6e-15 55.7 0.0 6e-15 55.7 0.0 2.7 2 1 0 2 2 2 1 Nucleoplasmin-like domain Nucleoplasmin PF03066.15 EEA06520.1 - 0.04 14.4 0.2 0.17 12.4 0.0 2.0 2 0 0 2 2 2 0 Nucleoplasmin/nucleophosmin domain Roughex PF06020.11 EEA06520.1 - 0.048 12.8 20.0 0.062 12.4 20.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Drc1-Sld2 PF11719.8 EEA06520.1 - 1.1 8.7 23.0 1.5 8.3 23.0 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Nop14 PF04147.12 EEA06520.1 - 2.9 6.0 36.6 3.7 5.6 36.6 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EEA06520.1 - 3.3 7.0 32.8 4.8 6.4 32.8 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EEA06520.1 - 4.2 6.7 34.8 7.1 6.0 34.8 1.3 1 0 0 1 1 1 0 SDA1 SURF2 PF05477.11 EEA06520.1 - 4.3 7.0 21.8 6.8 6.3 21.8 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) NAD_Gly3P_dh_N PF01210.23 EEA06521.1 - 3.4e-42 144.1 0.0 5.1e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EEA06521.1 - 2.2e-32 112.3 0.1 3.7e-32 111.5 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus YEATS PF03366.16 EEA06522.1 - 2.9e-30 104.1 0.2 6.5e-30 102.9 0.2 1.6 1 0 0 1 1 1 1 YEATS family UME PF08064.13 EEA06522.1 - 0.042 13.7 0.3 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 UME (NUC010) domain TBCC_N PF16752.5 EEA06522.1 - 1.2 9.6 10.6 5.9 7.4 2.4 3.3 1 1 2 3 3 3 0 Tubulin-specific chaperone C N-terminal domain DUF5339 PF17274.2 EEA06522.1 - 5.3 8.0 12.8 15 6.5 2.2 3.7 3 1 1 4 4 4 0 Family of unknown function (DUF5339) YabA PF06156.13 EEA06522.1 - 9.9 6.9 9.5 5.8 7.6 4.8 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Syja_N PF02383.18 EEA06523.1 - 3.6e-63 213.8 1.2 8.9e-63 212.5 1.2 1.7 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EEA06523.1 - 2.7e-06 27.1 0.0 6.7e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2026 PF09641.10 EEA06523.1 - 0.041 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2026) Ntox4 PF15541.6 EEA06523.1 - 0.19 12.1 0.0 0.39 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 4 zf-CCHC_3 PF13917.6 EEA06524.1 - 3.1e-06 27.0 0.9 3.1e-06 27.0 0.9 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 EEA06524.1 - 3.3e-05 23.7 3.2 8.8e-05 22.4 3.2 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 EEA06524.1 - 0.17 11.6 0.4 0.17 11.6 0.4 1.8 2 0 0 2 2 2 0 Zinc knuckle V-ATPase_G PF03179.15 EEA06526.1 - 2.8e-19 69.6 7.7 3.2e-19 69.4 7.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit SAPIS-gp6 PF16722.5 EEA06526.1 - 0.026 14.9 0.4 0.026 14.9 0.4 2.3 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus DUF3552 PF12072.8 EEA06526.1 - 0.75 9.2 12.7 0.66 9.4 8.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) eIF-3_zeta PF05091.12 EEA06528.1 - 5.6e-152 507.4 0.1 6.6e-152 507.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 EEA06528.1 - 0.0037 16.8 0.1 0.0062 16.1 0.1 1.4 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus DUF617 PF04759.13 EEA06528.1 - 0.0088 16.1 0.1 0.59 10.2 0.1 2.3 1 1 0 1 1 1 1 Protein of unknown function, DUF617 Ribosomal_L15e PF00827.17 EEA06529.1 - 7e-85 283.6 6.2 8.1e-85 283.4 6.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 Kelch_4 PF13418.6 EEA06531.1 - 3.7e-17 62.0 9.4 8.8e-06 25.6 0.4 5.0 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA06531.1 - 3.2e-14 52.6 8.6 0.00022 21.4 0.1 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EEA06531.1 - 4.1e-13 49.3 0.1 8.1e-05 22.8 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EEA06531.1 - 3.4e-08 33.3 2.7 0.16 12.0 0.1 4.8 4 0 0 4 4 4 3 Kelch motif HATPase_c_3 PF13589.6 EEA06531.1 - 6.4e-07 29.3 0.0 2e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_1 PF01344.25 EEA06531.1 - 1.1e-06 28.1 3.1 0.19 11.3 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EEA06531.1 - 0.02 14.8 9.5 16 5.7 0.2 5.5 6 0 0 6 6 6 0 Kelch motif BLUF PF04940.12 EEA06531.1 - 0.023 14.8 0.0 0.091 12.9 0.0 2.0 1 0 0 1 1 1 0 Sensors of blue-light using FAD Nucleoside_tran PF01733.18 EEA06532.1 - 5.1e-21 75.4 14.6 5.1e-21 75.4 14.6 1.5 2 0 0 2 2 2 1 Nucleoside transporter AHSA1 PF08327.11 EEA06533.1 - 3e-14 53.3 0.0 3.4e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein WD40 PF00400.32 EEA06534.1 - 5.4e-61 201.1 28.9 1.6e-10 41.4 0.4 9.5 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06534.1 - 2.8e-21 75.6 3.4 0.0095 16.2 0.1 6.7 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA06534.1 - 6.5e-10 38.5 1.0 0.019 13.9 0.0 4.9 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 EEA06534.1 - 1.7e-06 28.4 0.4 3.6e-06 27.4 0.4 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 EEA06534.1 - 9.3e-06 25.6 0.1 0.16 11.8 0.0 3.7 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EEA06534.1 - 0.0037 16.0 0.4 7.2 5.1 0.2 4.3 4 1 1 5 5 5 1 Nucleoporin Nup120/160 Frtz PF11768.8 EEA06534.1 - 0.026 12.9 0.0 1.7 6.9 0.0 2.4 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz IKI3 PF04762.12 EEA06534.1 - 0.12 10.4 0.2 0.39 8.7 0.0 1.9 2 0 0 2 2 2 0 IKI3 family Nbas_N PF15492.6 EEA06534.1 - 0.12 11.7 3.9 40 3.4 0.1 4.0 2 2 2 4 4 4 0 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 EEA06534.1 - 0.22 10.2 1.1 65 2.1 0.0 3.7 4 1 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 EEA06534.1 - 0.37 10.8 11.9 2.3 8.3 0.1 4.7 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat OTU PF02338.19 EEA06535.1 - 1.8e-21 76.9 2.0 3.7e-21 76.0 0.1 2.2 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EEA06535.1 - 6.7e-08 32.3 6.0 6.9e-06 25.7 0.0 3.0 2 1 1 3 3 3 2 Peptidase C65 Otubain MMR_HSR1_Xtn PF16897.5 EEA06535.1 - 0.039 14.0 4.3 0.13 12.3 0.4 2.4 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Pre-PUA PF17832.1 EEA06535.1 - 3.3 8.4 5.8 1.2 9.9 2.4 2.0 1 1 1 2 2 2 0 Pre-PUA-like domain ABC_tran PF00005.27 EEA06536.1 - 1.2e-33 116.5 0.0 3.7e-18 66.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA06536.1 - 6.1e-21 75.3 40.8 1.4e-15 57.7 14.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region FtsK_SpoIIIE PF01580.18 EEA06536.1 - 3.7e-06 26.5 0.3 0.012 15.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_29 PF13555.6 EEA06536.1 - 8.1e-06 25.5 0.7 0.032 14.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.6 EEA06536.1 - 3.5e-05 23.9 0.0 0.0003 21.0 0.0 2.2 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Pox_A32 PF04665.12 EEA06536.1 - 4e-05 23.2 0.7 0.44 10.0 0.0 3.2 3 0 0 3 3 2 2 Poxvirus A32 protein AAA_16 PF13191.6 EEA06536.1 - 5.4e-05 23.6 0.0 0.023 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EEA06536.1 - 6.4e-05 23.0 2.5 0.074 13.1 0.2 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 EEA06536.1 - 7.2e-05 22.7 1.1 1.7 8.4 0.2 4.0 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EEA06536.1 - 7.5e-05 23.0 0.2 0.34 11.2 0.0 3.0 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EEA06536.1 - 9.8e-05 22.3 0.1 0.08 12.9 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 EEA06536.1 - 0.00049 19.6 0.2 1.8 7.9 0.0 3.6 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 EEA06536.1 - 0.00056 20.1 4.3 0.01 15.9 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain T2SSE PF00437.20 EEA06536.1 - 0.00059 19.0 0.1 0.67 9.0 0.0 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein NACHT PF05729.12 EEA06536.1 - 0.00063 19.7 1.2 0.39 10.6 0.1 2.9 3 0 0 3 3 3 1 NACHT domain AAA_7 PF12775.7 EEA06536.1 - 0.0052 16.3 0.1 2.3 7.7 0.0 3.2 3 0 0 3 3 3 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EEA06536.1 - 0.0079 16.6 0.2 7.1 7.1 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 EEA06536.1 - 0.011 15.5 0.1 2.5 7.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 EEA06536.1 - 0.012 15.7 0.1 51 3.9 0.3 4.1 3 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Viral_helicase1 PF01443.18 EEA06536.1 - 0.034 13.9 0.0 9.1 5.9 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AIG1 PF04548.16 EEA06536.1 - 0.047 13.0 1.0 0.71 9.2 0.1 2.7 3 0 0 3 3 3 0 AIG1 family IstB_IS21 PF01695.17 EEA06536.1 - 0.049 13.4 0.2 2.7 7.7 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_23 PF13476.6 EEA06536.1 - 0.056 13.9 5.0 3.6 8.0 0.3 2.7 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 EEA06536.1 - 0.061 12.5 0.7 10 5.2 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain IIGP PF05049.13 EEA06536.1 - 0.071 12.1 2.0 5 6.1 0.0 2.8 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) PRK PF00485.18 EEA06536.1 - 0.1 12.3 1.5 7.9 6.2 0.1 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EEA06536.1 - 0.11 12.7 0.1 8.1 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EEA06536.1 - 0.11 12.6 10.5 0.24 11.4 1.3 2.8 3 0 0 3 3 2 0 Dynamin family AAA_18 PF13238.6 EEA06536.1 - 0.13 12.8 0.6 5.7 7.5 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EEA06536.1 - 0.19 11.4 0.0 13 5.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EEA06536.1 - 0.76 9.7 2.3 19 5.1 0.1 2.6 2 0 0 2 2 2 0 NTPase Aa_trans PF01490.18 EEA06537.1 - 5.9e-35 120.8 49.2 7.7e-35 120.4 49.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Thymidylat_synt PF00303.19 EEA06538.1 - 4.6e-108 360.4 0.0 6.4e-108 359.9 0.0 1.2 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 EEA06538.1 - 1.6e-33 115.7 0.0 1.8e-31 109.0 0.0 2.3 1 1 0 1 1 1 1 Dihydrofolate reductase DUF4236 PF14020.6 EEA06539.1 - 0.19 12.3 4.4 49 4.6 0.0 4.6 3 1 1 5 5 5 0 Protein of unknown function (DUF4236) DDHD PF02862.17 EEA06539.1 - 0.87 9.7 6.6 0.88 9.7 5.2 1.8 2 0 0 2 2 2 0 DDHD domain ThiF PF00899.21 EEA06540.1 - 1.1e-28 100.2 0.0 2e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 EEA06540.1 - 1.9e-11 44.2 7.1 3.3e-11 43.4 7.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Ephrin_rec_like PF07699.13 EEA06541.1 - 2e-06 27.4 10.4 2e-06 27.4 10.4 4.2 3 1 1 4 4 4 2 Putative ephrin-receptor like Wzy_C PF04932.15 EEA06541.1 - 0.68 9.5 4.4 3.8 7.1 0.1 2.6 2 0 0 2 2 2 0 O-Antigen ligase Mvb12 PF09452.10 EEA06542.1 - 0.02 15.3 0.5 0.029 14.8 0.5 1.2 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 Synaptobrevin PF00957.21 EEA06542.1 - 0.026 14.3 4.0 0.16 11.7 0.1 2.1 2 0 0 2 2 2 0 Synaptobrevin CCAP PF11105.8 EEA06542.1 - 0.61 10.0 2.9 0.74 9.8 0.9 2.0 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a O-antigen_lig PF13425.6 EEA06542.1 - 0.84 8.4 6.7 0.26 10.0 3.8 1.5 1 1 0 1 1 1 0 O-antigen ligase like membrane protein SUI1 PF01253.22 EEA06543.1 - 2.1e-14 53.8 0.0 4.9e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EEA06543.1 - 0.01 16.5 1.2 0.16 12.7 0.0 3.2 2 1 1 3 3 3 0 Pre-PUA-like domain PUA PF01472.20 EEA06543.1 - 0.04 13.9 0.0 0.13 12.2 0.0 2.0 1 0 0 1 1 1 0 PUA domain RL PF17797.1 EEA06543.1 - 0.12 12.4 0.5 0.34 10.9 0.5 1.8 1 0 0 1 1 1 0 RL domain Syja_N PF02383.18 EEA06544.1 - 1.7e-70 237.9 7.3 2.7e-70 237.2 7.3 1.3 1 0 0 1 1 1 1 SacI homology domain RRP7 PF12923.7 EEA06545.1 - 1.2e-16 60.9 1.1 2.5e-16 59.9 1.1 1.4 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 EEA06545.1 - 0.0023 17.7 0.6 0.0084 15.9 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) T4_Rnl2_C PF18043.1 EEA06545.1 - 0.042 14.0 5.0 0.28 11.3 1.4 2.8 1 1 1 2 2 2 0 T4 RNA ligase 2 C-terminal RRM_7 PF16367.5 EEA06545.1 - 0.073 13.2 0.4 0.21 11.7 0.1 1.9 2 0 0 2 2 2 0 RNA recognition motif Mito_carr PF00153.27 EEA06546.1 - 6.4e-40 135.0 2.9 3.6e-12 46.0 0.0 4.0 1 1 2 3 3 3 3 Mitochondrial carrier protein DUF4014 PF13198.6 EEA06546.1 - 0.012 16.0 0.8 18 5.8 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4014) HTH_9 PF08221.11 EEA06547.1 - 6.1e-05 23.0 3.9 0.00044 20.3 0.1 3.6 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain UPF0240 PF06784.11 EEA06547.1 - 0.026 14.6 0.3 0.078 13.0 0.3 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) TFIIE_alpha PF02002.17 EEA06547.1 - 0.52 10.2 18.2 0.17 11.8 1.5 4.6 5 0 0 5 5 5 0 TFIIE alpha subunit CAF1C_H4-bd PF12265.8 EEA06548.1 - 1.5e-14 53.9 0.3 3.1e-13 49.8 0.3 2.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EEA06548.1 - 2.4e-07 31.3 14.5 0.00016 22.4 0.5 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat KH_1 PF00013.29 EEA06549.1 - 0.13 12.1 0.3 0.34 10.8 0.0 1.9 2 0 0 2 2 2 0 KH domain Menin PF05053.13 EEA06549.1 - 7 4.9 16.0 12 4.2 16.0 1.4 1 0 0 1 1 1 0 Menin SNF2_N PF00176.23 EEA06550.1 - 2.9e-47 161.1 0.0 6.2e-22 77.8 0.1 3.6 2 2 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA06550.1 - 1e-16 61.2 0.0 8.9e-16 58.2 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 EEA06550.1 - 3.6e-06 27.2 3.9 3.6e-06 27.2 3.9 3.7 4 0 0 4 4 3 1 Ring finger domain zf-PARP PF00645.18 EEA06550.1 - 2.1e-05 25.3 0.0 2.1e-05 25.3 0.0 2.7 3 0 0 3 3 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-C3HC4_2 PF13923.6 EEA06550.1 - 8.8e-05 22.3 1.7 8.8e-05 22.3 1.7 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA06550.1 - 0.00037 20.2 4.4 0.00037 20.2 4.4 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EEA06550.1 - 0.00069 19.6 0.7 0.00069 19.6 0.7 2.3 3 0 0 3 3 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EEA06550.1 - 0.0018 18.3 0.2 0.0087 16.1 0.2 2.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EEA06550.1 - 0.0029 17.9 1.4 0.0029 17.9 1.4 2.8 4 0 0 4 4 3 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EEA06550.1 - 0.011 15.9 1.1 0.011 15.9 1.1 3.3 3 0 0 3 3 3 0 FANCL C-terminal domain zf-ribbon_3 PF13248.6 EEA06550.1 - 1.9 8.0 7.6 6.8 6.2 0.4 3.6 3 0 0 3 3 3 0 zinc-ribbon domain Nop PF01798.18 EEA06551.1 - 2.9e-61 206.9 0.7 2.9e-61 206.9 0.7 1.6 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EEA06551.1 - 2e-27 96.5 1.2 1.7e-26 93.5 0.2 2.3 2 1 0 2 2 2 1 Prp31 C terminal domain Xpo1 PF08389.12 EEA06551.1 - 0.023 14.8 1.6 0.42 10.7 0.7 2.7 3 0 0 3 3 3 0 Exportin 1-like protein DUF4477 PF14780.6 EEA06552.1 - 6e-05 22.8 3.0 0.067 12.8 0.4 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4477) MMS19_N PF14500.6 EEA06554.1 - 1.6e-28 100.1 0.1 1e-27 97.4 0.1 2.2 1 1 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II HVSL PF09749.9 EEA06554.1 - 0.037 13.5 2.5 0.036 13.5 1.1 1.6 1 1 1 2 2 2 0 Uncharacterised conserved protein Abp2 PF09441.10 EEA06555.1 - 0.11 12.5 0.8 0.33 11.0 0.8 1.8 1 0 0 1 1 1 0 ARS binding protein 2 UQ_con PF00179.26 EEA06557.1 - 4.4e-44 149.5 0.0 5.6e-44 149.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA06557.1 - 3.2e-06 26.9 0.0 4.1e-05 23.3 0.0 2.0 1 1 1 2 2 2 1 Prokaryotic E2 family B UBA PF00627.31 EEA06557.1 - 1e-05 25.3 0.0 2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain RWD PF05773.22 EEA06557.1 - 0.0013 19.1 0.1 0.0023 18.2 0.1 1.7 1 1 0 1 1 1 1 RWD domain DUF1940 PF09155.10 EEA06559.1 - 1.1 9.4 5.9 2.8 8.0 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1940) Pkinase PF00069.25 EEA06560.1 - 1.7e-56 191.5 0.0 3e-56 190.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06560.1 - 2.2e-17 63.2 0.0 5.7e-12 45.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA06560.1 - 6.5e-07 29.0 0.0 0.0044 16.4 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EEA06560.1 - 0.0019 17.6 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA06560.1 - 0.008 16.1 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EEA06560.1 - 0.0097 15.5 0.1 0.017 14.7 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase FTA2 PF13095.6 EEA06560.1 - 0.077 12.6 0.1 0.49 10.0 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 XPC-binding PF09280.11 EEA06560.1 - 0.09 12.5 0.1 0.92 9.3 0.0 2.5 2 0 0 2 2 2 0 XPC-binding domain CKS PF01111.19 EEA06561.1 - 2e-25 88.8 0.3 2.3e-25 88.6 0.3 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Proteasome PF00227.26 EEA06562.1 - 5e-57 192.5 0.0 6.2e-57 192.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA06562.1 - 8.6e-14 50.9 0.3 1.8e-13 49.9 0.3 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Prp18 PF02840.15 EEA06563.1 - 1.2e-05 25.4 0.1 6.6e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 Prp18 domain SRA1 PF07304.11 EEA06563.1 - 0.00026 20.8 0.0 0.00085 19.1 0.0 2.0 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) ANAPC4_WD40 PF12894.7 EEA06563.1 - 0.001 19.3 0.0 0.012 15.8 0.0 2.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA06563.1 - 0.0029 18.4 8.7 0.41 11.6 0.2 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Sec16_C PF12931.7 EEA06563.1 - 0.007 16.0 0.0 0.11 12.2 0.0 2.7 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Agenet PF05641.12 EEA06564.1 - 4.6e-05 23.8 0.4 0.00016 22.1 0.1 2.1 2 0 0 2 2 2 1 Agenet domain zf-C4H2 PF10146.9 EEA06564.1 - 0.19 12.0 4.9 0.063 13.6 2.5 1.5 2 0 0 2 2 2 0 Zinc finger-containing protein E3_UFM1_ligase PF09743.9 EEA06565.1 - 5.6e-50 170.5 15.8 5.6e-50 170.5 15.8 2.2 1 1 1 2 2 2 1 E3 UFM1-protein ligase 1 DS PF01916.17 EEA06565.1 - 0.017 14.3 0.7 6.2 6.0 0.4 2.5 2 0 0 2 2 2 0 Deoxyhypusine synthase B56 PF01603.20 EEA06566.1 - 4.3e-169 562.9 17.5 8e-169 562.0 17.5 1.5 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) ECD PF18432.1 EEA06566.1 - 0.018 15.0 0.0 0.048 13.6 0.0 1.7 1 0 0 1 1 1 0 Extracellular Cadherin domain APAF1_C PF17908.1 EEA06566.1 - 0.59 10.1 3.7 0.69 9.9 0.2 2.6 2 0 0 2 2 2 0 APAF-1 helical domain Abhydrolase_3 PF07859.13 EEA06567.1 - 7.1e-34 117.5 0.0 9.8e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EEA06567.1 - 7.7e-09 35.0 0.2 3.7e-08 32.7 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EEA06567.1 - 4.1e-05 22.6 0.4 0.00012 21.0 0.3 1.8 1 1 0 1 1 1 1 Steryl acetyl hydrolase CBFD_NFYB_HMF PF00808.23 EEA06568.1 - 7.2e-14 51.8 0.0 1.1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA06568.1 - 7.7e-09 36.0 0.0 1.5e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EEA06568.1 - 0.0024 18.0 0.0 0.0047 17.1 0.0 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Ras PF00071.22 EEA06569.1 - 6.9e-60 201.3 0.1 8.4e-60 201.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA06569.1 - 7.1e-36 123.1 0.0 1.1e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA06569.1 - 6.7e-14 51.7 0.0 9.1e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA06569.1 - 5.6e-07 29.6 0.0 9.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA06569.1 - 0.00011 22.1 0.0 0.02 14.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EEA06569.1 - 0.001 18.7 0.0 0.003 17.1 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EEA06569.1 - 0.0024 17.3 0.1 0.003 16.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EEA06569.1 - 0.0031 17.9 0.0 0.0052 17.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EEA06569.1 - 0.0031 17.2 0.0 0.01 15.6 0.0 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EEA06569.1 - 0.0086 16.3 0.0 0.038 14.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EEA06569.1 - 0.017 14.5 0.0 0.027 13.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EEA06569.1 - 0.024 15.2 0.4 0.079 13.5 0.4 2.1 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EEA06569.1 - 0.027 14.2 0.1 0.055 13.2 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 EEA06569.1 - 0.062 13.3 0.0 0.17 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EEA06569.1 - 0.063 12.7 0.1 0.19 11.1 0.0 1.8 2 1 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EEA06569.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 EEA06569.1 - 0.11 12.0 0.0 0.84 9.2 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_5 PF07728.14 EEA06569.1 - 0.14 12.2 0.0 0.41 10.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 EEA06569.1 - 0.18 11.5 0.5 0.26 11.0 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DWNN PF08783.11 EEA06570.1 - 3.5 8.0 8.5 1.1 9.6 1.4 2.7 3 1 0 3 3 3 0 DWNN domain TBCC PF07986.12 EEA06571.1 - 2e-12 46.9 5.5 4.3e-12 45.8 5.5 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EEA06571.1 - 0.17 11.5 7.1 0.43 10.2 7.1 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal TPR_2 PF07719.17 EEA06573.1 - 2.8e-15 55.1 12.1 0.0018 18.2 0.0 7.6 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06573.1 - 2.3e-10 40.6 5.8 1.4 9.3 0.1 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EEA06573.1 - 3.3e-09 36.2 19.3 0.0048 16.7 0.5 6.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EEA06573.1 - 9.5e-07 29.1 0.6 0.02 15.5 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EEA06573.1 - 1.3e-05 25.6 0.0 0.0023 18.6 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EEA06573.1 - 5.5e-05 23.1 14.9 0.18 12.1 0.2 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA06573.1 - 9.1e-05 22.2 6.8 0.34 11.0 0.2 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA06573.1 - 0.0011 19.1 21.3 0.23 11.7 0.6 6.6 3 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EEA06573.1 - 0.0013 18.6 2.0 2.2 8.3 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06573.1 - 0.012 15.3 0.0 32 4.3 0.0 4.1 3 0 0 3 3 3 0 TPR repeat PPR PF01535.20 EEA06573.1 - 0.038 14.2 0.0 0.4 11.1 0.0 2.9 2 0 0 2 2 1 0 PPR repeat TPR_3 PF07720.12 EEA06573.1 - 0.065 13.3 4.6 0.67 10.0 0.7 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA06573.1 - 0.069 13.8 0.1 1 10.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EEA06573.1 - 1.8 8.7 8.0 1.2 9.3 0.1 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain SET PF00856.28 EEA06574.1 - 1.5e-14 54.8 3.9 1.6e-14 54.6 0.1 2.9 2 2 0 2 2 2 1 SET domain DUF3331 PF11811.8 EEA06574.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3331) MFS_1 PF07690.16 EEA06575.1 - 3.6e-25 88.6 27.2 1.1e-24 87.1 15.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily CDP-OH_P_transf PF01066.21 EEA06576.1 - 3.9e-13 49.9 0.5 3.9e-13 49.9 0.5 3.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TPR_1 PF00515.28 EEA06577.1 - 2.7e-09 36.5 11.5 4.3e-05 23.1 0.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA06577.1 - 1.6e-08 34.0 4.8 0.0061 16.6 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06577.1 - 0.00086 18.9 0.9 0.29 10.9 0.1 3.0 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 EEA06577.1 - 0.0036 17.8 1.9 0.013 16.0 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06577.1 - 0.006 16.8 0.4 0.16 12.2 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EEA06577.1 - 0.007 16.4 1.0 0.13 12.3 0.1 3.0 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EEA06577.1 - 0.009 16.2 2.3 0.026 14.7 1.3 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EEA06577.1 - 0.017 15.3 12.2 0.28 11.5 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat NdhM PF10664.9 EEA06577.1 - 0.04 14.2 0.9 0.16 12.2 0.2 2.4 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M TPR_6 PF13174.6 EEA06577.1 - 0.078 13.7 5.1 0.55 11.0 0.6 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat YbfN PF13982.6 EEA06577.1 - 0.092 13.0 0.4 0.092 13.0 0.4 3.6 4 0 0 4 4 4 0 YbfN-like lipoprotein HEAT_2 PF13646.6 EEA06578.1 - 5.7e-18 65.1 0.0 1.7e-11 44.4 0.0 3.4 2 1 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 EEA06578.1 - 1.1e-14 53.5 0.0 0.012 16.2 0.0 5.8 6 0 0 6 6 6 3 PBS lyase HEAT-like repeat HEAT PF02985.22 EEA06578.1 - 1.8e-10 40.1 0.2 3 8.3 0.0 7.6 7 1 1 8 8 8 2 HEAT repeat Cnd1 PF12717.7 EEA06578.1 - 0.0025 17.9 8.6 0.66 10.0 4.2 4.0 1 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 EEA06578.1 - 0.028 14.7 0.1 4.1 7.8 0.0 3.7 4 1 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain HEAT_EZ PF13513.6 EEA06578.1 - 0.061 13.8 0.1 42 4.8 0.0 4.7 5 2 0 5 5 5 0 HEAT-like repeat PC_rep PF01851.22 EEA06578.1 - 0.18 12.3 0.7 1.5e+02 3.1 0.0 4.2 4 0 0 4 4 4 0 Proteasome/cyclosome repeat UPF0016 PF01169.19 EEA06579.1 - 5.8e-39 132.3 9.6 5.7e-21 74.6 0.3 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mntp PF02659.15 EEA06579.1 - 0.0013 18.5 4.4 0.024 14.4 0.1 2.2 2 0 0 2 2 2 2 Putative manganese efflux pump SLATT_6 PF18169.1 EEA06579.1 - 0.0096 15.5 0.6 0.018 14.7 0.4 1.5 1 1 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 6 TerC PF03741.16 EEA06579.1 - 0.023 14.4 7.9 0.14 11.9 2.3 2.3 2 0 0 2 2 2 0 Integral membrane protein TerC family LysE PF01810.18 EEA06579.1 - 1.2 8.5 10.5 5.2 6.5 1.5 3.4 2 2 0 2 2 2 0 LysE type translocator DUF21 PF01595.20 EEA06579.1 - 4.9 6.8 8.6 2.2 8.0 6.0 1.7 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain ORC5_C PF14630.6 EEA06580.1 - 9.5e-24 84.4 0.1 2e-23 83.3 0.1 1.7 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus XPG_N PF00752.17 EEA06581.1 - 9.9e-28 96.6 0.0 3e-27 95.1 0.0 1.9 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EEA06581.1 - 4.7e-21 74.9 0.1 4.7e-21 74.9 0.1 3.3 5 0 0 5 5 5 1 XPG I-region ACI44 PF15270.6 EEA06581.1 - 0.8 10.0 4.5 1.3 9.3 0.3 2.6 2 0 0 2 2 2 0 Metallo-carboxypeptidase inhibitor 5_3_exonuc PF01367.20 EEA06581.1 - 0.95 10.1 0.0 0.95 10.1 0.0 4.1 3 1 1 4 4 4 0 5'-3' exonuclease, C-terminal SAM fold BLM10_mid PF16507.5 EEA06582.1 - 3.6e-30 105.1 1.9 1.7e-28 99.6 1.8 3.4 2 1 0 2 2 2 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EEA06582.1 - 2.6e-25 88.2 0.0 8.2e-25 86.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) CLASP_N PF12348.8 EEA06582.1 - 0.014 15.0 0.1 0.055 13.0 0.1 2.0 1 0 0 1 1 1 0 CLASP N terminal Nup54 PF13874.6 EEA06583.1 - 1.3e-21 77.2 6.8 1.3e-21 77.2 6.8 1.9 3 0 0 3 3 3 1 Nucleoporin complex subunit 54 DUF5329 PF17263.2 EEA06583.1 - 0.065 13.4 0.7 0.16 12.2 0.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5329) Ribosomal_L18 PF17135.4 EEA06584.1 - 3.2e-83 277.7 3.6 3.5e-83 277.6 3.6 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EEA06584.1 - 0.00016 22.3 0.0 0.0005 20.7 0.0 1.8 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A FOG_N PF15888.5 EEA06587.1 - 0.057 13.8 0.1 0.057 13.8 0.1 8.8 6 4 2 8 8 8 0 Folded gastrulation N-terminus CC PF04942.14 EEA06587.1 - 0.12 12.6 0.2 0.12 12.6 0.2 5.4 5 1 1 6 6 6 0 CC domain Lipase3_N PF03893.16 EEA06588.1 - 0.05 13.6 0.1 0.2 11.7 0.0 2.1 2 0 0 2 2 2 0 Lipase 3 N-terminal region HSA PF07529.13 EEA06589.1 - 2.1e-15 56.8 1.4 7.5e-15 55.0 1.4 2.0 1 0 0 1 1 1 1 HSA Myb_DNA-bind_6 PF13921.6 EEA06589.1 - 0.00061 20.0 0.1 0.00061 20.0 0.1 2.9 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EEA06589.1 - 0.11 12.7 0.5 0.36 11.0 0.0 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain FliC PF12445.8 EEA06589.1 - 2.7 8.4 7.0 1.1 9.6 1.9 2.5 2 0 0 2 2 2 0 Flagellin protein SAP PF02037.27 EEA06590.1 - 0.0008 19.1 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 SAP domain VWA_2 PF13519.6 EEA06591.1 - 1.7e-17 64.0 0.8 4.1e-16 59.5 0.0 2.9 3 0 0 3 3 3 1 von Willebrand factor type A domain TBK1_CCD1 PF18394.1 EEA06591.1 - 0.044 13.4 0.1 0.068 12.7 0.1 1.2 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 UIM PF02809.20 EEA06591.1 - 0.084 12.8 7.6 1.2 9.2 0.3 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif V-ATPase_C PF03223.15 EEA06592.1 - 2.7e-94 316.6 4.3 3.2e-94 316.4 4.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C FlxA PF14282.6 EEA06593.1 - 0.037 14.0 2.4 0.037 14.0 2.4 2.9 3 0 0 3 3 3 0 FlxA-like protein RP-C_C PF11800.8 EEA06593.1 - 0.046 13.8 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region Allexi_40kDa PF05549.11 EEA06593.1 - 0.29 10.6 5.8 3.6 7.0 0.2 2.5 2 1 0 2 2 2 0 Allexivirus 40kDa protein DegS PF05384.11 EEA06593.1 - 1.6 8.2 7.0 4.2 6.8 0.1 3.0 2 1 2 4 4 4 0 Sensor protein DegS DOT1 PF08123.13 EEA06594.1 - 0.094 12.2 1.2 3.4 7.1 0.2 2.8 3 0 0 3 3 3 0 Histone methylation protein DOT1 Mito_carr PF00153.27 EEA06595.1 - 1.6e-18 66.4 0.5 1.7e-06 27.9 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF1564 PF07600.11 EEA06595.1 - 0.005 16.5 1.1 0.014 15.1 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1564) UQ_con PF00179.26 EEA06596.1 - 1.2e-51 174.0 0.0 1.4e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA06596.1 - 3.5e-05 23.5 0.0 4.3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EEA06596.1 - 0.0033 17.7 0.0 0.0033 17.7 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EEA06596.1 - 0.0088 15.9 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 UEV domain G-gamma PF00631.22 EEA06596.1 - 0.023 14.7 0.0 0.052 13.6 0.0 1.6 1 0 0 1 1 1 0 GGL domain EPL1 PF10513.9 EEA06597.1 - 1.4e-13 51.5 1.8 3.5e-13 50.2 1.8 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like Helicase_C PF00271.31 EEA06597.1 - 0.0052 17.1 0.3 0.026 14.9 0.0 2.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain NTF2 PF02136.20 EEA06598.1 - 9.1e-33 113.4 0.0 1e-32 113.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 EEA06598.1 - 0.17 11.0 0.1 0.25 10.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) AP2 PF00847.20 EEA06599.1 - 5.4e-07 29.7 0.2 1.6e-06 28.2 0.2 1.8 1 0 0 1 1 1 1 AP2 domain Cnd3 PF12719.7 EEA06599.1 - 0.025 13.8 1.3 0.044 13.0 1.3 1.4 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain Diphthami_syn_2 PF01902.17 EEA06600.1 - 2.2e-28 99.3 0.0 4.9e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 Diphthamide synthase Peptidase_S26 PF10502.9 EEA06601.1 - 1.6e-06 27.9 0.0 3e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EEA06601.1 - 0.00011 22.1 0.0 0.00024 21.0 0.0 1.6 1 1 1 2 2 2 1 Peptidase S24-like XPA_C PF05181.12 EEA06602.1 - 5.2e-15 55.1 3.6 6.3e-15 54.9 2.3 1.8 2 0 0 2 2 2 1 XPA protein C-terminus fn3 PF00041.21 EEA06603.1 - 2.1e-05 24.8 0.5 2.1e-05 24.8 0.5 4.2 4 0 0 4 4 4 1 Fibronectin type III domain Spt5-NGN PF03439.13 EEA06603.1 - 0.11 12.4 0.0 0.56 10.1 0.0 2.2 2 0 0 2 2 2 0 Early transcription elongation factor of RNA pol II, NGN section DUF3591 PF12157.8 EEA06604.1 - 9.3e-36 123.4 3.8 2.4e-19 69.4 0.0 3.8 4 1 0 4 4 4 2 Protein of unknown function (DUF3591) Bromodomain PF00439.25 EEA06604.1 - 1.6e-14 53.7 2.1 2e-14 53.4 0.1 2.3 2 0 0 2 2 2 1 Bromodomain zf-CCHC_6 PF15288.6 EEA06604.1 - 9.3e-05 22.2 0.3 0.0002 21.1 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EEA06604.1 - 0.002 18.1 0.6 0.0043 17.1 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle UPF0113_N PF17833.1 EEA06606.1 - 1.6e-30 105.5 0.2 2.7e-30 104.7 0.2 1.4 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EEA06606.1 - 5.6e-21 74.6 0.1 1.5e-20 73.2 0.1 1.7 2 0 0 2 2 2 1 UPF0113 PUA domain PUA PF01472.20 EEA06606.1 - 0.055 13.4 0.2 0.13 12.3 0.0 1.6 2 0 0 2 2 2 0 PUA domain MRF_C1 PF13887.6 EEA06606.1 - 0.081 12.1 0.4 5.6 6.2 0.1 3.0 3 0 0 3 3 3 0 Myelin gene regulatory factor -C-terminal domain 1 DUF2672 PF10878.8 EEA06607.1 - 0.12 12.3 0.1 0.35 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2672) Prok-E2_C PF14459.6 EEA06607.1 - 1.8 8.7 3.5 29 4.8 0.1 3.2 4 0 0 4 4 4 0 Prokaryotic E2 family C AP2 PF00847.20 EEA06608.1 - 0.9 9.8 3.4 0.9 9.8 1.6 1.9 2 0 0 2 2 2 0 AP2 domain POR_N PF01855.19 EEA06609.1 - 6e-74 248.7 0.1 1.1e-72 244.6 0.5 2.1 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg FAD_binding_1 PF00667.20 EEA06609.1 - 9.9e-36 123.4 0.0 1.8e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain POR PF01558.18 EEA06609.1 - 7.5e-30 104.3 0.0 1.6e-29 103.2 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Flavodoxin_1 PF00258.25 EEA06609.1 - 1.6e-26 93.2 0.1 3.5e-26 92.1 0.1 1.6 1 0 0 1 1 1 1 Flavodoxin EKR PF10371.9 EEA06609.1 - 9.8e-17 60.5 0.0 8.2e-16 57.6 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function Fer4_7 PF12838.7 EEA06609.1 - 2.9e-09 37.4 3.1 2.9e-09 37.4 3.1 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain PFOR_II PF17147.4 EEA06609.1 - 3.3e-09 37.0 0.2 1.1e-08 35.3 0.0 2.0 2 0 0 2 2 1 1 Pyruvate:ferredoxin oxidoreductase core domain II NAD_binding_1 PF00175.21 EEA06609.1 - 5e-09 36.8 0.0 2.1e-08 34.8 0.0 2.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain TPP_enzyme_C PF02775.21 EEA06609.1 - 3.1e-08 33.6 0.1 9.2e-08 32.0 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fer4_16 PF13484.6 EEA06609.1 - 5.3e-08 33.7 6.4 2.9e-06 28.1 7.3 2.8 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 EEA06609.1 - 1.7e-07 31.3 4.7 1.7e-07 31.3 4.7 2.6 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EEA06609.1 - 2e-07 31.0 6.7 2e-07 31.0 6.7 2.3 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 EEA06609.1 - 3.8e-07 29.7 12.7 1.8e-05 24.3 3.2 3.8 4 0 0 4 4 4 2 4Fe-4S binding domain Fer4_17 PF13534.6 EEA06609.1 - 8.5e-06 26.2 4.8 5.6e-05 23.6 4.8 2.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EEA06609.1 - 3e-05 24.1 12.4 3e-05 24.1 12.4 2.9 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EEA06609.1 - 5.5e-05 23.5 4.3 5.5e-05 23.5 4.3 2.1 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EEA06609.1 - 0.0002 21.3 4.9 0.0002 21.3 4.9 3.6 5 0 0 5 5 3 2 4Fe-4S binding domain Fer4_2 PF12797.7 EEA06609.1 - 0.0002 21.3 18.3 0.017 15.2 2.9 3.5 3 0 0 3 3 3 2 4Fe-4S binding domain Flavodoxin_5 PF12724.7 EEA06609.1 - 0.073 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain Fer4_18 PF13746.6 EEA06609.1 - 0.47 10.7 8.9 1.6 9.0 6.6 2.7 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EEA06609.1 - 1.4 9.6 13.2 4.7 7.8 2.3 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_4 PF12800.7 EEA06609.1 - 2.7 8.7 17.4 0.52 11.0 1.3 3.7 3 0 0 3 3 2 0 4Fe-4S binding domain Sacchrp_dh_NADP PF03435.18 EEA06610.1 - 7.2e-09 36.0 0.0 1.7e-08 34.8 0.0 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain RRM_1 PF00076.22 EEA06611.1 - 1.5e-05 24.7 0.0 0.015 15.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA06611.1 - 0.0064 16.3 0.1 1.8 8.5 0.0 3.0 3 0 0 3 3 3 2 Occluded RNA-recognition motif RL PF17797.1 EEA06611.1 - 0.024 14.6 0.2 0.13 12.2 0.0 2.3 3 0 0 3 3 3 0 RL domain Bacteroid_pep PF14406.6 EEA06611.1 - 1.1 9.6 8.2 0.2 12.0 2.2 2.5 2 1 0 2 2 2 0 Ribosomally synthesized peptide in Bacteroidetes NAP PF00956.18 EEA06612.1 - 3.2e-62 210.2 7.7 3.1e-60 203.6 7.7 2.3 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 EEA06612.1 - 0.0074 16.0 9.6 0.0074 16.0 9.6 1.8 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EEA06612.1 - 0.085 12.2 11.7 0.11 11.8 11.7 1.3 1 0 0 1 1 1 0 NOA36 protein TFIIA PF03153.13 EEA06612.1 - 0.47 10.4 11.5 0.64 10.0 11.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2457 PF10446.9 EEA06612.1 - 1.4 8.0 24.1 2.5 7.2 24.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 EEA06612.1 - 1.8 6.7 12.4 2.2 6.4 12.4 1.2 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EEA06612.1 - 2.8 5.9 20.3 4.2 5.4 20.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 EEA06612.1 - 7.4 5.0 12.6 10 4.5 12.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AhpC-TSA PF00578.21 EEA06614.1 - 2.3e-35 121.2 0.0 3e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EEA06614.1 - 2.5e-16 59.7 0.0 3.1e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EEA06614.1 - 1.9e-11 43.6 0.0 3.7e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 EEA06614.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 SCO1/SenC Kazal_2 PF07648.15 EEA06615.1 - 5e-41 138.6 73.0 7.6e-08 32.4 1.1 8.3 8 0 0 8 8 8 7 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EEA06615.1 - 3.8e-29 100.5 71.4 6e-07 29.4 1.9 8.2 8 0 0 8 8 8 7 Kazal-type serine protease inhibitor domain Prefoldin PF02996.17 EEA06616.1 - 2.7e-08 33.8 0.4 9.2e-08 32.0 0.4 1.9 1 1 0 1 1 1 1 Prefoldin subunit DUF3287 PF11690.8 EEA06616.1 - 0.003 17.3 0.1 0.0083 15.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3287) SWIRM-assoc_1 PF16495.5 EEA06616.1 - 0.16 12.0 2.6 12 6.0 1.2 2.3 2 0 0 2 2 2 0 SWIRM-associated region 1 ASF1_hist_chap PF04729.13 EEA06617.1 - 5.4e-63 211.5 0.0 8e-63 211.0 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone DNA_topoisoIV PF00521.20 EEA06619.1 - 9.2e-117 390.5 23.4 3.5e-83 279.9 0.1 3.5 3 0 0 3 3 3 2 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EEA06619.1 - 2.1e-44 150.9 7.0 2.1e-44 150.9 7.0 3.3 3 1 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EEA06619.1 - 6e-19 68.2 0.1 1.9e-18 66.6 0.1 1.8 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EEA06619.1 - 3.4e-11 43.6 0.2 2.2e-10 41.0 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EEA06619.1 - 8.1e-08 32.4 0.2 1.9e-06 28.0 0.0 3.2 3 0 0 3 3 3 1 Toprim domain zf-met2 PF12907.7 EEA06620.1 - 9.1e-14 51.3 3.0 1.2e-13 50.9 3.0 1.2 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 EEA06620.1 - 3.1e-09 37.5 0.6 4.1e-09 37.2 0.6 1.2 1 0 0 1 1 1 1 4F5 protein family zf-C2H2_12 PF18658.1 EEA06620.1 - 0.0047 16.5 0.4 0.0066 16.0 0.4 1.2 1 0 0 1 1 1 1 Zinc-finger C2H2-type U3_snoRNA_assoc PF08297.11 EEA06620.1 - 0.1 13.3 0.0 0.15 12.8 0.0 1.2 1 0 0 1 1 1 0 U3 snoRNA associated DUF4519 PF15012.6 EEA06620.1 - 0.89 9.8 3.5 8.9 6.6 3.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4519) Yip1 PF04893.17 EEA06621.1 - 2.1e-06 27.6 13.2 3e-06 27.1 13.2 1.2 1 0 0 1 1 1 1 Yip1 domain UDPGP PF01704.18 EEA06622.1 - 1.7e-39 135.7 2.8 3.9e-39 134.5 2.7 1.5 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase V-SNARE_C PF12352.8 EEA06623.1 - 2.6e-12 46.8 3.2 8.3e-12 45.2 3.2 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EEA06623.1 - 0.035 14.0 2.3 0.035 14.0 2.3 2.5 2 1 0 2 2 2 0 Sec20 DUF16 PF01519.16 EEA06623.1 - 0.036 14.5 18.4 0.032 14.7 6.2 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF745 PF05335.13 EEA06623.1 - 0.32 10.7 3.8 4.6 6.9 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF3450 PF11932.8 EEA06623.1 - 2.1 7.6 16.7 0.99 8.6 6.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) ABC2_membrane_3 PF12698.7 EEA06623.1 - 3.4 6.7 9.8 5.1 6.1 9.8 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DnaJ_C PF01556.18 EEA06624.1 - 2.6e-41 141.2 0.4 3.6e-41 140.7 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA06624.1 - 4.7e-26 90.7 4.1 7.9e-26 90.0 4.1 1.4 1 0 0 1 1 1 1 DnaJ domain ATP-grasp_5 PF13549.6 EEA06626.1 - 4.8e-61 206.0 0.0 2.7e-60 203.6 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EEA06626.1 - 2.9e-52 176.1 0.2 6.3e-52 175.0 0.2 1.6 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EEA06626.1 - 1.7e-22 80.1 0.0 5.8e-22 78.4 0.0 2.0 1 0 0 1 1 1 1 CoA binding domain Acetyltransf_1 PF00583.25 EEA06626.1 - 4.3e-12 46.3 0.0 9.4e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EEA06626.1 - 1.6e-08 35.3 0.0 3.9e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA06626.1 - 4.9e-06 26.8 0.0 0.00013 22.1 0.0 2.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain CoA_binding PF02629.19 EEA06626.1 - 7.5e-06 26.5 0.1 2.6e-05 24.8 0.1 2.0 1 0 0 1 1 1 1 CoA binding domain Acetyltransf_10 PF13673.7 EEA06626.1 - 0.00015 21.7 0.0 0.00077 19.4 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain ATP-grasp_2 PF08442.10 EEA06626.1 - 0.00054 19.6 0.0 0.0014 18.2 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EEA06626.1 - 0.0039 16.7 0.0 0.0075 15.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Acetyltransf_7 PF13508.7 EEA06626.1 - 0.0052 17.2 0.0 0.014 15.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Thioredoxin PF00085.20 EEA06627.1 - 3.9e-06 26.8 0.2 0.064 13.3 0.1 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EEA06627.1 - 1.1e-05 25.4 3.3 0.36 10.7 0.1 3.4 2 1 0 3 3 3 3 Thioredoxin-like domain NTP_transferase PF00483.23 EEA06628.1 - 6.3e-40 137.3 0.0 9.5e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EEA06628.1 - 5.1e-12 45.0 9.6 1.1e-06 28.1 2.1 4.0 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EEA06628.1 - 9.2e-07 29.4 0.0 1.3e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EEA06628.1 - 0.0039 15.4 2.4 0.006 14.8 2.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EEA06628.1 - 1.5 8.6 11.0 0.53 10.1 4.2 3.6 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase ArfGap PF01412.18 EEA06629.1 - 3.6e-39 133.5 0.2 3.6e-39 133.5 0.2 2.8 3 1 1 4 4 4 1 Putative GTPase activating protein for Arf EAV_GS PF01309.18 EEA06629.1 - 0.17 11.5 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein zf-RING_UBOX PF13445.6 EEA06630.1 - 8.1e-05 22.6 16.8 9.9e-05 22.3 9.6 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EEA06630.1 - 0.00019 21.7 13.7 0.0006 20.1 13.7 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EEA06630.1 - 0.0002 21.2 10.7 0.0006 19.6 10.4 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA06630.1 - 0.0003 20.5 12.2 0.0037 17.1 12.7 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA06630.1 - 0.00093 19.3 11.8 0.0059 16.7 12.0 2.4 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EEA06630.1 - 0.022 14.7 13.6 0.14 12.2 13.8 2.4 1 1 1 2 2 2 0 zinc-RING finger domain DUF2439 PF10382.9 EEA06630.1 - 0.19 12.1 2.0 8.9 6.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) Prok-RING_4 PF14447.6 EEA06630.1 - 3 7.8 14.2 62 3.6 0.2 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EEA06630.1 - 4.2 7.2 11.7 1.5 8.6 5.3 3.1 2 2 0 2 2 2 0 RING-like zinc finger SWIRM PF04433.17 EEA06631.1 - 1.6e-29 102.0 0.5 1.3e-28 99.1 0.0 2.6 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EEA06631.1 - 1.4e-21 76.2 6.9 4.6e-21 74.6 6.9 1.9 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EEA06631.1 - 7.8e-13 48.4 0.0 2e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA06631.1 - 2.3e-08 34.2 0.0 6.1e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Phage_GP20 PF06810.11 EEA06631.1 - 0.063 13.1 0.2 0.063 13.1 0.2 3.0 3 0 0 3 3 3 0 Phage minor structural protein GP20 PDEase_I PF00233.19 EEA06634.1 - 0.0062 16.3 0.8 0.017 14.8 0.8 1.8 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase MitMem_reg PF13012.6 EEA06634.1 - 0.86 10.0 4.5 0.4 11.1 0.5 2.5 3 0 0 3 3 3 0 Maintenance of mitochondrial structure and function EF-hand_1 PF00036.32 EEA06635.1 - 4.8e-12 44.5 1.0 7.6e-05 22.0 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EEA06635.1 - 6.8e-12 44.3 0.3 0.00024 20.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EEA06635.1 - 4e-11 43.2 0.2 6.4e-05 23.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA06635.1 - 3.7e-06 26.7 4.9 0.04 13.8 0.2 3.9 3 2 2 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA06635.1 - 3.7e-06 26.2 0.4 0.0038 16.7 0.2 2.6 3 0 0 3 3 3 2 EF hand Caleosin PF05042.13 EEA06635.1 - 0.00029 20.8 0.1 0.011 15.6 0.1 2.1 2 0 0 2 2 2 1 Caleosin related protein EF-hand_9 PF14658.6 EEA06635.1 - 0.0031 17.8 0.2 0.031 14.6 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain DUF751 PF05421.11 EEA06637.1 - 0.11 13.2 3.1 6.6 7.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF751) zf-Tim10_DDP PF02953.15 EEA06638.1 - 2.1e-17 62.5 1.7 2.9e-17 62.1 1.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger ING PF12998.7 EEA06639.1 - 5e-18 65.6 1.8 5e-18 65.6 1.8 2.2 3 0 0 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding zf-RING_9 PF13901.6 EEA06639.1 - 7.9 6.4 18.1 5.5 6.9 12.3 2.5 2 1 1 3 3 3 0 Putative zinc-RING and/or ribbon CBFD_NFYB_HMF PF00808.23 EEA06640.1 - 6.8e-05 23.1 1.5 0.00015 21.9 1.5 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EEA06640.1 - 0.0022 18.3 0.5 0.0041 17.5 0.5 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF4595 PF15283.6 EEA06640.1 - 0.046 13.8 4.3 0.057 13.5 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4595) with porin-like fold Pro_isomerase PF00160.21 EEA06641.1 - 9.6e-49 165.7 0.0 1.1e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DDOST_48kD PF03345.14 EEA06642.1 - 7.3e-103 344.6 1.3 9.5e-103 344.2 1.3 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Baculo_11_kDa PF06143.11 EEA06642.1 - 0.081 12.5 2.8 0.21 11.2 2.8 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family Metallophos PF00149.28 EEA06643.1 - 1.1e-22 81.6 8.0 2.9e-22 80.2 8.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 EEA06643.1 - 2.5e-10 39.1 2.8 0.0015 18.0 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EEA06643.1 - 5.7e-10 38.3 0.7 0.0009 19.0 0.0 4.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EEA06643.1 - 1.1e-08 35.4 1.1 0.0017 18.7 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA06643.1 - 4.5e-07 29.6 0.4 0.00096 19.0 0.3 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA06643.1 - 0.0025 17.2 2.0 2.5 7.7 0.0 3.4 3 0 0 3 3 3 2 EF hand dCMP_cyt_deam_1 PF00383.23 EEA06644.1 - 1.5e-15 56.9 0.2 2.4e-15 56.2 0.2 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA06644.1 - 3.7e-15 55.9 0.3 3e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 EEA06644.1 - 0.01 15.9 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 Bd3614-like deaminase TACI-CRD2 PF09305.10 EEA06644.1 - 0.11 12.6 0.4 1.2 9.2 0.1 2.5 1 1 1 2 2 2 0 TACI, cysteine-rich domain SPARC_Ca_bdg PF10591.9 EEA06645.1 - 0.032 14.6 0.3 0.096 13.0 0.3 1.9 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.25 EEA06646.1 - 6.6e-46 156.8 0.0 7.1e-45 153.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06646.1 - 1.2e-17 64.1 0.0 3.8e-09 36.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA06646.1 - 0.00079 18.3 0.0 0.0014 17.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EEA06646.1 - 0.0017 17.8 0.0 0.036 13.4 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family MCM PF00493.23 EEA06647.1 - 1.6e-86 289.1 0.0 2.4e-86 288.5 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EEA06647.1 - 1.7e-28 99.0 0.4 4e-28 97.8 0.4 1.7 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EEA06647.1 - 5e-21 74.9 0.1 1.7e-20 73.2 0.1 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EEA06647.1 - 1.7e-08 35.0 0.1 4.3e-08 33.7 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EEA06647.1 - 1.9e-07 30.7 0.2 7e-05 22.3 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EEA06647.1 - 0.0049 16.7 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA06647.1 - 0.0077 16.2 0.0 0.03 14.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EEA06647.1 - 0.0097 15.6 0.0 0.18 11.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 EEA06647.1 - 0.072 13.5 0.0 0.28 11.6 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) EGF_CA PF07645.15 EEA06648.1 - 8.4e-21 73.9 76.5 2.3e-10 40.5 7.8 7.0 7 0 0 7 7 7 4 Calcium-binding EGF domain cEGF PF12662.7 EEA06648.1 - 1.1e-18 66.8 39.9 1.1e-08 34.8 3.9 7.2 7 0 0 7 7 7 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EEA06648.1 - 5.1e-10 39.5 63.0 5e-07 29.9 11.7 7.2 6 1 1 7 7 7 5 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EEA06648.1 - 6e-05 23.1 7.5 0.00031 20.9 2.0 7.1 8 0 0 8 8 8 4 EGF domain hEGF PF12661.7 EEA06648.1 - 0.00052 20.6 46.9 0.0028 18.2 1.5 7.6 7 0 0 7 7 7 4 Human growth factor-like EGF EGF PF00008.27 EEA06648.1 - 0.0095 16.2 1.3 0.0095 16.2 1.3 7.0 7 1 0 7 7 7 5 EGF-like domain ATG_C PF09333.11 EEA06648.1 - 0.047 14.0 0.0 0.097 13.0 0.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain DUF35_N PF12172.8 EEA06649.1 - 0.0057 16.5 2.0 0.91 9.5 0.1 2.4 2 0 0 2 2 2 2 Rubredoxin-like zinc ribbon domain (DUF35_N) Vps26 PF03643.15 EEA06651.1 - 3.3e-99 331.3 2.3 4e-99 331.1 2.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 EEA06651.1 - 0.00056 20.4 0.2 0.0056 17.1 0.1 2.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EEA06651.1 - 0.0059 16.7 2.7 10 6.2 0.1 3.6 3 1 1 4 4 4 3 Arrestin (or S-antigen), N-terminal domain AAA_22 PF13401.6 EEA06653.1 - 0.005 17.1 0.0 0.016 15.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain Fungal_TACC PF12709.7 EEA06653.1 - 0.014 15.8 1.0 0.045 14.2 1.0 1.9 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins TniB PF05621.11 EEA06653.1 - 0.034 13.6 0.0 0.093 12.1 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 EEA06653.1 - 0.045 14.1 0.0 0.14 12.5 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain zf-LYAR PF08790.11 EEA06654.1 - 8.2e-14 51.2 7.8 8.2e-14 51.2 7.8 2.5 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 EEA06654.1 - 0.0039 16.7 3.4 0.81 9.3 0.1 2.8 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger Transposase_24 PF03004.14 EEA06654.1 - 0.015 15.4 1.9 0.019 15.0 1.1 1.6 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) DUF463 PF04317.12 EEA06654.1 - 0.017 14.1 0.0 0.019 13.9 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 TRAF6_Z2 PF18048.1 EEA06654.1 - 0.051 13.7 1.9 0.051 13.7 1.9 1.9 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 LepB_N PF18640.1 EEA06654.1 - 0.056 13.1 0.2 0.062 12.9 0.2 1.2 1 0 0 1 1 1 0 LepB N-terminal domain zf-TRAF PF02176.18 EEA06654.1 - 0.24 12.1 5.6 0.28 11.9 3.3 2.1 2 0 0 2 2 2 0 TRAF-type zinc finger Cys_box PF17869.1 EEA06654.1 - 3.2 7.9 11.2 1.6 8.9 6.3 2.4 2 1 0 2 2 2 0 Anosmin cysteine rich domain NPR2 PF06218.11 EEA06655.1 - 3.2e-34 118.5 11.4 5.2e-30 104.6 6.2 2.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 CorA PF01544.18 EEA06656.1 - 0.00045 19.6 0.1 0.00099 18.5 0.1 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein TruD PF01142.18 EEA06657.1 - 9.8e-52 176.2 1.6 4.6e-49 167.3 0.2 2.8 3 0 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) PCI PF01399.27 EEA06658.1 - 2.8e-11 43.8 1.8 3.9e-11 43.4 0.4 2.0 2 0 0 2 2 2 1 PCI domain eIF3_N PF09440.10 EEA06658.1 - 2.5e-06 28.0 2.1 5.3e-06 26.9 1.2 2.0 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain DUF1084 PF06454.11 EEA06659.1 - 1.9e-13 50.4 19.8 1.9e-13 50.4 19.8 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1084) RRM_1 PF00076.22 EEA06660.1 - 1.6e-14 53.5 0.0 1.8e-09 37.2 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bromo_TP PF07524.13 EEA06661.1 - 2.7e-05 24.1 0.0 4.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.9 EEA06661.1 - 0.0079 16.7 2.4 0.021 15.4 2.4 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term TFIID-31kDa PF02291.15 EEA06661.1 - 0.056 13.5 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit ThiF PF00899.21 EEA06662.1 - 1.4e-56 191.6 0.0 2.6e-56 190.7 0.0 1.4 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EEA06662.1 - 1.8e-19 70.1 0.9 5.1e-19 68.6 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EEA06662.1 - 8.7e-09 35.7 3.1 6.8e-05 22.9 0.1 2.9 1 1 2 3 3 3 2 Ubiquitin-activating enzyme active site Sacchrp_dh_NADP PF03435.18 EEA06662.1 - 0.0013 19.0 2.4 0.054 13.8 2.4 2.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EEA06662.1 - 0.054 13.9 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 EEA06662.1 - 0.095 13.3 0.3 0.33 11.6 0.3 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EEA06662.1 - 0.1 12.2 1.5 0.12 11.9 0.2 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain OATP PF03137.20 EEA06663.1 - 1.3e-20 73.2 32.8 2.5e-15 55.8 5.1 3.2 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EEA06663.1 - 4.3e-19 68.7 34.0 4.3e-19 68.7 34.0 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA06663.1 - 4.6e-05 22.5 14.9 4.6e-05 22.5 14.9 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter Proteasome PF00227.26 EEA06664.1 - 5e-54 182.7 0.1 6.1e-54 182.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA06664.1 - 2.8e-14 52.5 0.0 4.6e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Dynactin_p62 PF05502.13 EEA06665.1 - 2.1e-17 63.1 15.2 9.3e-14 51.1 8.9 2.3 2 0 0 2 2 2 2 Dynactin p62 family TMEM154 PF15102.6 EEA06666.1 - 0.027 14.4 0.0 0.06 13.3 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family DnaJ PF00226.31 EEA06667.1 - 3.2e-08 33.6 0.0 8.2e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain DUF1754 PF08555.10 EEA06668.1 - 0.00025 21.8 8.3 0.0018 19.0 8.3 2.0 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) MTS_N PF08468.11 EEA06669.1 - 0.11 12.5 6.2 4.9 7.2 0.4 3.4 3 1 0 3 3 3 0 Methyltransferase small domain N-terminal DUF3440 PF11922.8 EEA06669.1 - 0.17 11.5 2.5 0.65 9.7 2.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) zf-C4H2 PF10146.9 EEA06669.1 - 4.3 7.6 13.4 8.6 6.6 13.4 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein CtaG_Cox11 PF04442.14 EEA06670.1 - 0.057 13.4 0.1 0.089 12.8 0.1 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein CtaG/Cox11 TRPM_tetra PF16519.5 EEA06671.1 - 0.12 12.5 0.3 3.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Tetramerisation domain of TRPM ABC_tran_CTD PF16326.5 EEA06671.1 - 0.17 12.1 0.1 0.39 11.0 0.1 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain LSM PF01423.22 EEA06674.1 - 1.1e-18 66.7 0.2 1.3e-18 66.4 0.2 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EEA06674.1 - 0.0043 17.1 0.0 0.0062 16.6 0.0 1.2 1 0 0 1 1 1 1 RimP C-terminal SH3 domain Gemin6 PF06372.12 EEA06674.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Gemin6 protein PP2C PF00481.21 EEA06675.1 - 9.9e-50 169.6 0.2 7.9e-48 163.3 0.2 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C DivIC PF04977.15 EEA06676.1 - 0.0081 15.9 2.3 0.0081 15.9 2.3 2.5 2 0 0 2 2 2 1 Septum formation initiator Drf_FH1 PF06346.12 EEA06676.1 - 0.022 14.5 0.7 0.032 14.0 0.7 1.2 1 0 0 1 1 1 0 Formin Homology Region 1 KLRAQ PF10205.9 EEA06676.1 - 0.034 14.4 10.2 0.048 13.9 1.5 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Swi5 PF07061.11 EEA06676.1 - 0.46 10.6 4.5 0.59 10.2 1.6 2.5 2 0 0 2 2 2 0 Swi5 Promethin PF16015.5 EEA06678.1 - 0.012 15.5 8.8 0.022 14.7 8.8 1.4 1 0 0 1 1 1 0 Promethin DUF2207 PF09972.9 EEA06678.1 - 1.6 7.4 6.1 2.1 7.0 6.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Kelch_4 PF13418.6 EEA06681.1 - 5.7e-31 106.3 8.6 9.6e-07 28.7 0.0 6.8 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EEA06681.1 - 1.1e-27 95.7 1.4 5.1e-05 23.4 0.0 6.7 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EEA06681.1 - 7.3e-26 89.7 11.3 8.6e-07 28.8 0.2 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EEA06681.1 - 3.6e-24 84.2 18.3 7.8e-06 26.0 0.2 6.5 5 1 1 6 6 6 6 Kelch motif DUF4110 PF13422.6 EEA06681.1 - 1e-17 63.9 1.5 1e-17 63.9 1.5 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_1 PF01344.25 EEA06681.1 - 3.5e-13 48.9 13.8 5.3e-05 22.7 0.3 6.7 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EEA06681.1 - 1.3e-10 40.8 21.0 0.0013 18.6 0.4 7.1 6 1 0 6 6 6 4 Kelch motif Mpp10 PF04006.12 EEA06682.1 - 1.4e-58 198.9 47.7 1.9e-34 119.1 11.4 3.0 2 1 0 2 2 2 2 Mpp10 protein PRMT5 PF05185.16 EEA06683.1 - 2.7e-63 212.9 0.1 4.7e-63 212.1 0.1 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EEA06683.1 - 1.5e-42 145.4 5.9 4.2e-42 144.0 5.9 1.7 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 EEA06683.1 - 6.4e-12 45.2 5.0 1.1e-11 44.4 5.0 1.5 1 0 0 1 1 1 1 PRMT5 TIM barrel domain AAR2 PF05282.11 EEA06684.1 - 4.5e-61 207.2 0.0 5.4e-61 207.0 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein Mito_carr PF00153.27 EEA06685.1 - 9e-68 224.3 2.5 2.9e-22 78.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EEA06685.1 - 0.099 13.0 0.0 0.29 11.5 0.0 1.7 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Kelch_1 PF01344.25 EEA06686.1 - 9.9e-50 165.9 12.6 1.1e-09 37.7 0.6 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EEA06686.1 - 2.4e-45 152.0 13.8 1.7e-08 34.6 0.7 8.1 8 0 0 8 8 8 7 Galactose oxidase, central domain Kelch_6 PF13964.6 EEA06686.1 - 1.2e-42 142.8 16.4 1e-08 35.1 0.1 7.0 4 2 2 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EEA06686.1 - 2.6e-40 135.8 4.7 2.1e-07 30.8 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EEA06686.1 - 9.5e-34 115.2 15.0 4.7e-06 26.5 0.1 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 EEA06686.1 - 9.2e-32 107.8 17.1 1.4e-06 28.0 0.1 6.5 6 0 0 6 6 6 6 Kelch motif BTB PF00651.31 EEA06686.1 - 1.2e-14 54.4 0.4 3.1e-14 53.1 0.4 1.7 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EEA06686.1 - 1.5e-05 25.0 1.3 9.6e-05 22.4 0.3 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch RAG2 PF03089.14 EEA06686.1 - 0.028 13.4 0.2 9.3 5.1 0.1 3.3 3 1 0 3 3 3 0 Recombination activating protein 2 Skp1_POZ PF03931.15 EEA06686.1 - 0.039 14.1 0.3 1.1 9.5 0.3 2.5 1 1 0 1 1 1 0 Skp1 family, tetramerisation domain CTD_bind PF04818.13 EEA06687.1 - 3e-06 27.9 2.8 1.4e-05 25.8 0.1 2.9 3 0 0 3 3 3 1 RNA polymerase II-binding domain. Cullin PF00888.22 EEA06687.1 - 0.015 13.9 2.3 0.018 13.7 0.8 1.7 1 1 1 2 2 2 0 Cullin family PP2C PF00481.21 EEA06688.1 - 4.9e-35 121.4 0.0 7.8e-34 117.5 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C OCRE PF17780.1 EEA06688.1 - 3e-06 27.2 0.7 6.7e-06 26.0 0.7 1.6 1 0 0 1 1 1 1 OCRE domain MHC_II_beta PF00969.19 EEA06688.1 - 0.0082 16.2 0.5 0.034 14.2 0.5 2.0 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain SpoIIE PF07228.12 EEA06688.1 - 0.1 12.5 0.0 0.38 10.6 0.0 1.8 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) DUF5454 PF17535.2 EEA06688.1 - 0.21 11.0 4.2 0.37 10.1 4.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5454) PAP_assoc PF03828.19 EEA06689.1 - 2.2e-08 34.2 0.2 6.1e-08 32.8 0.2 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EEA06689.1 - 3.4e-06 27.3 0.0 1.5e-05 25.2 0.0 2.1 2 0 0 2 2 2 1 Nucleotidyltransferase domain Binary_toxB_3 PF17476.2 EEA06690.1 - 4.5 7.5 9.0 0.29 11.3 1.5 3.0 3 0 0 3 3 3 0 Clostridial binary toxin B/anthrax toxin PA domain 3 Carb_kinase PF01256.17 EEA06691.1 - 2.4e-47 161.5 0.0 2e-33 115.9 0.0 2.2 2 0 0 2 2 2 2 Carbohydrate kinase E2F_TDP PF02319.20 EEA06692.1 - 3.3e-10 39.9 0.2 1e-09 38.3 0.2 1.9 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Pox_LP_H2 PF03356.15 EEA06692.1 - 0.038 13.9 0.2 0.072 13.0 0.2 1.4 1 0 0 1 1 1 0 Viral late protein H2 Stn1_C PF12659.7 EEA06692.1 - 0.071 13.1 3.7 0.12 12.3 0.1 2.5 2 1 0 2 2 2 0 Telomere capping C-terminal wHTH Proteasome PF00227.26 EEA06693.1 - 7.3e-61 205.0 0.1 1.3e-60 204.2 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA06693.1 - 5.2e-11 42.0 0.1 2.5e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature HSP90 PF00183.18 EEA06694.1 - 3.4e-154 514.6 27.2 6e-152 507.2 20.1 2.7 1 1 2 3 3 3 2 Hsp90 protein HATPase_c_3 PF13589.6 EEA06694.1 - 1.1e-10 41.4 0.1 1.1e-10 41.4 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EEA06694.1 - 3.9e-09 37.0 0.1 8.1e-09 36.0 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YycC PF14174.6 EEA06694.1 - 0.06 13.2 0.1 0.2 11.5 0.1 2.0 1 0 0 1 1 1 0 YycC-like protein FAM150 PF15129.6 EEA06694.1 - 0.11 12.7 3.2 0.7 10.1 3.1 2.4 2 0 0 2 2 2 0 FAM150 family Cgr1 PF03879.14 EEA06694.1 - 2.2 8.7 8.7 5.8 7.3 8.7 1.7 1 0 0 1 1 1 0 Cgr1 family TPR_2 PF07719.17 EEA06695.1 - 4.1e-27 92.1 3.9 0.0019 18.1 0.1 8.3 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 EEA06695.1 - 8.5e-26 88.7 5.3 2.6e-07 30.2 0.1 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06695.1 - 6.1e-20 70.6 6.6 1.5e-06 27.7 0.0 5.4 2 2 3 5 5 5 4 TPR repeat ANAPC3 PF12895.7 EEA06695.1 - 7.4e-18 64.6 20.5 5.9e-06 26.4 0.5 6.8 3 1 4 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EEA06695.1 - 5.4e-15 55.6 1.5 0.00036 21.0 0.0 6.2 4 1 3 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EEA06695.1 - 1.4e-14 54.4 0.0 1.8e-08 34.9 0.0 3.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06695.1 - 1.9e-13 50.5 7.9 0.001 19.3 0.0 5.7 5 2 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA06695.1 - 2.4e-13 49.2 6.9 9.5e-05 22.3 0.1 7.0 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA06695.1 - 1e-11 44.6 0.1 0.051 14.4 0.1 6.0 4 2 4 8 8 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EEA06695.1 - 4.5e-09 36.1 1.2 1 9.9 0.0 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EEA06695.1 - 2e-08 33.7 4.3 1.7 8.9 0.1 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA06695.1 - 2.3e-06 27.7 0.9 0.02 15.0 0.0 3.3 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 EEA06695.1 - 0.00016 22.1 4.7 24 5.8 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EEA06695.1 - 0.0023 17.9 3.4 1.1 9.3 0.1 3.8 3 1 1 4 4 3 1 Putative TPR-like repeat TPR_15 PF13429.6 EEA06695.1 - 0.0031 16.8 1.4 0.29 10.3 0.2 3.4 3 1 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EEA06695.1 - 0.0063 16.0 0.0 1.3 8.6 0.0 3.8 3 0 0 3 3 3 1 SHNi-TPR TPR_3 PF07720.12 EEA06695.1 - 0.032 14.2 0.2 1.9 8.6 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Coatomer_E PF04733.14 EEA06695.1 - 0.043 13.2 0.1 1.1 8.6 0.0 2.5 2 0 0 2 2 2 0 Coatomer epsilon subunit TPR_10 PF13374.6 EEA06695.1 - 0.082 12.8 1.4 17 5.4 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EEA06695.1 - 0.45 10.6 4.6 22 5.2 0.1 4.1 5 0 0 5 5 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EEA06695.1 - 0.52 10.4 5.9 3.2 7.9 0.1 4.4 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EEA06696.1 - 3.4e-15 55.4 1.1 0.19 12.6 0.0 9.2 6 2 4 10 10 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 EEA06696.1 - 1.7e-13 50.8 2.9 0.00062 20.2 0.0 6.2 5 1 1 7 7 6 2 Tetratricopeptide repeat Suf PF05843.14 EEA06696.1 - 2.7e-06 27.6 21.1 6.7e-05 23.0 3.2 5.0 3 2 0 3 3 3 1 Suppressor of forked protein (Suf) TPR_2 PF07719.17 EEA06696.1 - 6.8e-06 25.8 10.9 1.4 9.2 0.2 7.6 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06696.1 - 1.3e-05 25.4 1.9 0.96 9.8 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA06696.1 - 2.2e-05 24.5 2.2 0.96 10.0 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EEA06696.1 - 0.00028 20.4 0.0 1.1 8.6 0.0 4.1 4 0 0 4 4 4 1 MalT-like TPR region TPR_6 PF13174.6 EEA06696.1 - 0.00029 21.3 3.8 14 6.5 0.1 6.8 6 0 0 6 6 6 0 Tetratricopeptide repeat HAT PF02184.16 EEA06696.1 - 0.00092 19.1 11.9 3.1 7.8 1.0 6.3 6 1 0 6 6 6 1 HAT (Half-A-TPR) repeat TPR_10 PF13374.6 EEA06696.1 - 0.0024 17.7 0.9 14 5.7 0.1 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA06696.1 - 0.011 16.4 0.0 61 4.4 0.0 4.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EEA06696.1 - 0.025 14.6 6.7 19 5.2 0.1 5.6 5 1 0 5 5 5 0 Mad3/BUB1 homology region 1 U3_assoc_6 PF08640.11 EEA06696.1 - 0.026 14.6 1.9 0.026 14.6 1.9 5.5 2 2 4 6 6 6 0 U3 small nucleolar RNA-associated protein 6 TPR_8 PF13181.6 EEA06696.1 - 0.038 14.2 18.9 2.9 8.3 0.4 6.5 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA06696.1 - 0.41 10.8 2.2 28 5.0 0.0 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA06696.1 - 2 8.4 8.3 33 4.5 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-RING_2 PF13639.6 EEA06697.1 - 2.6e-11 43.7 6.8 2.6e-11 43.7 6.8 2.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA06697.1 - 4.1e-09 36.1 4.7 1.5e-08 34.3 4.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA06697.1 - 1.1e-07 32.0 6.6 1.1e-07 32.0 6.6 2.4 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EEA06697.1 - 2.2e-07 30.7 7.4 3.2e-07 30.1 5.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA06697.1 - 2.4e-07 30.7 2.4 6.4e-07 29.3 2.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EEA06697.1 - 2.5e-06 27.2 3.9 5.4e-06 26.2 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA06697.1 - 4e-06 26.7 4.8 8.7e-06 25.6 4.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EEA06697.1 - 1e-05 25.1 2.9 2.7e-05 23.7 2.9 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EEA06697.1 - 3.4e-05 23.5 3.3 3.4e-05 23.5 3.3 2.8 3 0 0 3 3 3 1 RING-like zinc finger Prok-RING_4 PF14447.6 EEA06697.1 - 0.0011 18.8 4.7 0.0026 17.6 4.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EEA06697.1 - 0.077 13.2 4.9 0.21 11.8 4.9 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 EEA06697.1 - 0.12 11.7 0.3 0.2 11.0 0.3 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger zf-ANAPC11 PF12861.7 EEA06697.1 - 0.14 12.2 8.4 0.048 13.7 4.1 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 EEA06697.1 - 0.28 11.3 7.1 0.91 9.7 7.1 2.0 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EEA06697.1 - 0.57 10.0 5.1 1.8 8.4 5.1 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zf_RING PF16744.5 EEA06697.1 - 1 9.5 8.4 1.5 9.0 6.4 2.4 2 1 0 2 2 2 0 KIAA1045 RING finger MobL PF18555.1 EEA06698.1 - 0.0033 16.7 0.3 0.0048 16.2 0.3 1.2 1 0 0 1 1 1 1 MobL relaxases LRR_4 PF12799.7 EEA06699.1 - 3.8e-05 24.0 7.4 0.0021 18.4 0.8 10.2 6 3 5 11 11 11 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EEA06699.1 - 0.0017 18.3 41.2 0.51 10.5 0.0 11.4 12 0 0 12 12 12 4 Leucine Rich repeat MiAMP1 PF09117.10 EEA06699.1 - 0.0076 16.5 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 MiAMP1 Cys_rich_VLP PF14194.6 EEA06699.1 - 0.11 12.7 9.1 0.42 10.8 0.6 3.3 3 0 0 3 3 3 0 Cysteine-rich VLP LRR_1 PF00560.33 EEA06699.1 - 7.1 7.6 0.0 7.1 7.6 0.0 12.4 13 2 0 13 13 13 0 Leucine Rich Repeat IBR PF01485.21 EEA06700.1 - 9.8e-16 57.7 32.0 2.7e-10 40.3 8.8 3.3 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain DnaJ PF00226.31 EEA06701.1 - 4e-17 62.1 0.5 7.7e-17 61.2 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain DUF3395 PF11875.8 EEA06701.1 - 1.4e-08 34.8 0.0 3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) Cecropin PF00272.19 EEA06701.1 - 0.22 11.3 1.5 0.46 10.2 1.5 1.4 1 0 0 1 1 1 0 Cecropin family DUSP PF06337.12 EEA06701.1 - 0.56 10.9 4.8 0.55 10.9 0.3 3.0 1 1 1 2 2 2 0 DUSP domain PP-binding_2 PF14573.6 EEA06702.1 - 3e-10 40.2 0.4 6.4e-10 39.1 0.4 1.5 1 0 0 1 1 1 1 Acyl-carrier PP-binding PF00550.25 EEA06702.1 - 1.1e-06 28.8 0.0 2.9e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site RNA_pol_Rpb2_6 PF00562.28 EEA06703.1 - 9.6e-127 423.3 0.0 1.3e-126 422.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EEA06703.1 - 1.5e-54 184.6 0.0 2.2e-54 184.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EEA06703.1 - 7.3e-45 152.9 0.0 1.2e-44 152.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EEA06703.1 - 7.5e-32 109.6 1.0 1.7e-31 108.5 1.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EEA06703.1 - 8.5e-24 83.5 0.0 2.7e-23 81.9 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EEA06703.1 - 2e-20 73.1 1.1 4.9e-20 71.8 1.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 EEA06703.1 - 2.2e-19 69.5 0.1 6.6e-19 68.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RecR PF02132.15 EEA06703.1 - 0.61 9.7 2.6 1.8 8.2 2.6 1.8 1 0 0 1 1 1 0 RecR protein polyprenyl_synt PF00348.17 EEA06704.1 - 1.9e-53 181.1 0.0 2.7e-53 180.7 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase RNA_pol_Rpb4 PF03874.16 EEA06704.1 - 0.021 15.2 12.5 0.77 10.1 2.1 4.2 2 2 1 3 3 3 0 RNA polymerase Rpb4 DUF2608 PF11019.8 EEA06705.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Acid_PPase PF12689.7 EEA06705.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Acid Phosphatase COG4 PF08318.12 EEA06706.1 - 2.8e-24 85.8 2.4 9.2e-12 44.7 0.0 2.7 2 0 0 2 2 2 2 COG4 transport protein Fzo_mitofusin PF04799.13 EEA06706.1 - 0.0063 16.1 1.7 2.8 7.4 0.0 2.7 2 0 0 2 2 2 2 fzo-like conserved region DUF3212 PF11486.8 EEA06706.1 - 0.37 10.8 6.1 0.4 10.7 0.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3212) FlaC_arch PF05377.11 EEA06706.1 - 7 7.1 8.2 23 5.5 0.1 4.2 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Pkinase PF00069.25 EEA06707.1 - 2.9e-59 200.6 0.0 4.6e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06707.1 - 9.4e-34 116.9 0.0 1.6e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA06707.1 - 1e-08 34.9 0.0 1.3e-07 31.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EEA06707.1 - 0.00053 18.9 0.0 0.0013 17.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EEA06707.1 - 0.014 15.3 0.0 0.48 10.3 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family HSBP1 PF06825.12 EEA06708.1 - 2.7e-12 46.3 3.2 6.5e-12 45.1 2.8 1.9 1 1 0 1 1 1 1 Heat shock factor binding protein 1 Tektin PF03148.14 EEA06708.1 - 0.00049 19.0 0.9 0.00051 18.9 0.9 1.1 1 0 0 1 1 1 1 Tektin family Laminin_II PF06009.12 EEA06708.1 - 0.0054 16.8 0.7 0.0067 16.4 0.7 1.3 1 0 0 1 1 1 1 Laminin Domain II TBCC_N PF16752.5 EEA06708.1 - 0.0085 16.5 0.6 0.011 16.2 0.6 1.4 1 1 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain COG5 PF10392.9 EEA06708.1 - 0.012 15.7 2.4 1.1 9.5 0.1 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF1664 PF07889.12 EEA06708.1 - 0.014 15.4 0.9 0.019 15.0 0.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF848 PF05852.11 EEA06708.1 - 0.057 13.5 1.1 0.076 13.1 0.8 1.3 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF5446 PF17522.2 EEA06708.1 - 0.11 12.7 3.3 1.1 9.5 1.0 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5446) Cyclin PF08613.11 EEA06709.1 - 9.9e-30 104.0 0.8 3.5e-29 102.3 0.8 2.0 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA06709.1 - 1e-08 34.9 0.1 1.9e-08 34.1 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Myosin_head PF00063.21 EEA06710.1 - 3.5e-183 610.5 3.8 4.5e-183 610.1 3.8 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) DEAD PF00270.29 EEA06710.1 - 0.0044 16.8 0.5 1.2 8.9 0.1 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA06710.1 - 0.0068 16.7 0.0 0.031 14.6 0.0 2.1 1 0 0 1 1 1 1 AAA domain ATP-synt_ab PF00006.25 EEA06710.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.6 EEA06710.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain DsbG_N PF18257.1 EEA06710.1 - 0.23 11.6 3.3 0.45 10.7 1.2 2.4 2 0 0 2 2 2 0 Disulfide isomerase DsbG N-terminal DUF3994 PF13159.6 EEA06711.1 - 0.11 13.1 0.1 0.14 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) IL7 PF01415.16 EEA06714.1 - 0.18 11.8 2.6 19 5.3 0.1 3.7 4 0 0 4 4 4 0 Interleukin 7/9 family EnY2 PF10163.9 EEA06714.1 - 0.2 12.1 1.5 19 5.7 0.0 3.1 3 0 0 3 3 3 0 Transcription factor e(y)2 FAM180 PF15173.6 EEA06717.1 - 0.11 12.5 0.2 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 FAM180 family EB1 PF03271.17 EEA06720.1 - 0.082 13.2 0.4 1.1 9.6 0.0 3.0 2 0 0 2 2 2 0 EB1-like C-terminal motif GPS2_interact PF15784.5 EEA06720.1 - 0.34 11.4 12.5 5.8 7.4 5.8 3.4 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain CHD5 PF04420.14 EEA06720.1 - 9.8 6.0 13.1 0.069 13.0 2.4 2.8 2 0 0 2 2 2 0 CHD5-like protein DnaJ PF00226.31 EEA06721.1 - 4.2e-21 74.8 0.4 1.2e-20 73.4 0.4 1.9 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EEA06721.1 - 1.1e-13 51.0 0.1 1.6e-13 50.4 0.1 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DUF898 PF05987.13 EEA06721.1 - 0.013 14.6 0.6 0.02 14.0 0.6 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF1275 PF06912.11 EEA06721.1 - 0.12 12.2 0.6 0.32 10.9 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1275) BatA PF07584.11 EEA06721.1 - 0.79 10.1 3.5 0.51 10.7 0.4 2.2 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Pkinase PF00069.25 EEA06723.1 - 1.4e-69 234.4 0.0 1.7e-69 234.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06723.1 - 7.7e-38 130.3 0.0 9.7e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA06723.1 - 5e-06 26.0 0.0 1.2e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EEA06723.1 - 0.00038 19.9 0.0 0.00055 19.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA06723.1 - 0.00054 20.0 0.0 0.073 13.0 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA06723.1 - 0.014 14.3 0.2 0.029 13.3 0.2 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EEA06723.1 - 0.11 11.2 0.0 0.29 9.9 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase DUF4420 PF14390.6 EEA06724.1 - 0.007 15.6 0.8 0.012 14.9 0.8 1.5 1 0 0 1 1 1 1 Putative PD-(D/E)XK family member, (DUF4420) DUF5601 PF18151.1 EEA06724.1 - 0.029 14.7 0.2 0.029 14.7 0.2 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5601) Lact-deh-memb PF09330.11 EEA06724.1 - 0.056 12.8 0.3 0.56 9.5 0.1 2.0 2 0 0 2 2 2 0 D-lactate dehydrogenase, membrane binding GrpE PF01025.19 EEA06724.1 - 0.56 9.9 6.3 0.72 9.5 2.9 2.3 1 1 1 2 2 2 0 GrpE DUF1664 PF07889.12 EEA06724.1 - 0.85 9.7 5.5 0.86 9.6 2.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Swi5 PF07061.11 EEA06724.1 - 4 7.6 8.9 2.9 8.1 0.5 3.2 2 1 1 3 3 3 0 Swi5 MSC PF09402.10 EEA06725.1 - 4.5e-09 36.2 1.8 4.5e-09 36.2 1.8 2.0 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain Glyco_transf_64 PF09258.10 EEA06725.1 - 0.34 10.2 4.8 1.6 7.9 0.5 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 64 domain Fer2_3 PF13085.6 EEA06726.1 - 2.1e-30 105.0 0.0 5.3e-30 103.6 0.0 1.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 EEA06726.1 - 6.1e-11 42.6 0.8 3.2e-05 24.3 0.4 2.5 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 EEA06726.1 - 2e-09 37.8 4.9 2e-09 37.8 4.9 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EEA06726.1 - 2.5e-07 30.7 2.1 2.5e-07 30.7 2.1 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EEA06726.1 - 0.0031 18.1 3.3 0.0031 18.1 3.3 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EEA06726.1 - 0.0036 17.2 0.4 0.0036 17.2 0.4 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 EEA06726.1 - 0.097 12.9 10.6 0.19 11.9 7.8 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain MMtag PF10159.9 EEA06727.1 - 1.3e-18 67.0 0.5 4e-18 65.5 0.5 1.8 1 0 0 1 1 1 1 Multiple myeloma tumor-associated ThiF PF00899.21 EEA06728.1 - 9.8e-10 38.2 0.0 1.3e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 ThiF family Viral_cys_rich PF08008.12 EEA06728.1 - 0.018 15.1 0.2 0.059 13.4 0.0 1.9 2 0 0 2 2 2 0 Viral cysteine rich DEAD PF00270.29 EEA06729.1 - 4.2e-41 140.6 0.0 7.2e-41 139.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06729.1 - 8.5e-32 109.8 0.1 1.2e-30 106.1 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06729.1 - 0.0028 17.7 0.0 0.0067 16.5 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EEA06729.1 - 0.0046 17.3 0.1 0.012 15.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA06729.1 - 0.0061 16.8 0.1 0.02 15.2 0.0 1.9 2 1 0 2 2 2 1 AAA domain ERCC3_RAD25_C PF16203.5 EEA06729.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 EEA06729.1 - 0.026 14.2 0.0 0.077 12.7 0.0 1.7 2 1 0 2 2 2 0 AAA domain CMS1 PF14617.6 EEA06729.1 - 0.051 12.9 0.1 0.08 12.3 0.1 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit FF PF01846.19 EEA06730.1 - 1.9e-05 24.7 6.6 2.5e-05 24.4 0.1 3.7 3 0 0 3 3 3 1 FF domain WD40 PF00400.32 EEA06731.1 - 4.2e-39 131.8 7.9 2.5e-08 34.4 0.4 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06731.1 - 7e-08 32.7 0.4 0.04 14.2 0.0 4.3 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA06731.1 - 0.0019 17.0 1.2 0.32 9.6 0.0 3.8 2 2 3 5 5 5 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EEA06731.1 - 0.0078 15.0 0.3 2.9 6.6 0.1 2.5 2 0 0 2 2 2 2 Nup133 N terminal like 7TM_GPCR_Sri PF10327.9 EEA06731.1 - 0.24 10.5 0.0 0.36 10.0 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri Alba PF01918.21 EEA06732.1 - 0.013 15.3 0.4 0.02 14.7 0.4 1.3 1 0 0 1 1 1 0 Alba LSM PF01423.22 EEA06733.1 - 2.4e-18 65.6 1.6 3e-18 65.3 1.6 1.1 1 0 0 1 1 1 1 LSM domain OTU PF02338.19 EEA06734.1 - 9.8e-18 64.9 0.1 1.9e-17 64.0 0.1 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EEA06734.1 - 1.5e-08 34.4 1.6 0.00083 18.9 0.0 2.6 1 1 2 3 3 3 2 Peptidase C65 Otubain PX PF00787.24 EEA06735.1 - 3.5e-15 56.0 0.1 7.2e-15 55.0 0.1 1.6 1 0 0 1 1 1 1 PX domain Atg8 PF02991.16 EEA06736.1 - 5.9e-32 109.9 1.4 1.3e-30 105.6 1.4 2.0 1 1 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EEA06736.1 - 0.00051 20.4 0.6 0.0051 17.2 0.6 2.0 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 MIP-T3_C PF17749.1 EEA06737.1 - 0.17 11.8 5.9 0.34 10.9 5.9 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region Seryl_tRNA_N PF02403.22 EEA06737.1 - 0.78 10.0 9.9 13 6.0 5.4 2.7 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3091 PF11291.8 EEA06737.1 - 2 8.6 10.9 0.12 12.5 2.3 3.2 2 2 2 4 4 4 0 Protein of unknown function (DUF3091) RCC1 PF00415.18 EEA06738.1 - 5.6e-09 36.5 0.0 4.1e-05 24.1 0.0 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA06738.1 - 5.1e-07 29.3 5.3 7.5e-05 22.4 0.2 3.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat TMPIT PF07851.13 EEA06738.1 - 0.48 9.6 30.6 0.015 14.6 7.4 2.9 2 1 0 2 2 2 0 TMPIT-like protein OCRE PF17780.1 EEA06739.1 - 1e-19 70.3 5.1 0.075 13.1 0.0 14.5 14 1 1 15 15 15 5 OCRE domain YL1_C PF08265.11 EEA06739.1 - 4.5 7.1 40.4 4.9 7.0 0.1 14.6 17 1 1 18 18 18 0 YL1 nuclear protein C-terminal domain Sbt_1 PF05982.12 EEA06741.1 - 0.0027 17.0 0.0 0.003 16.9 0.0 1.0 1 0 0 1 1 1 1 Na+-dependent bicarbonate transporter superfamily FecCD PF01032.18 EEA06741.1 - 0.019 14.0 1.9 0.023 13.7 1.9 1.0 1 0 0 1 1 1 0 FecCD transport family DUF3671 PF12420.8 EEA06741.1 - 0.033 14.3 0.4 0.042 13.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function SUR7 PF06687.12 EEA06741.1 - 0.056 13.1 0.1 0.058 13.0 0.1 1.1 1 0 0 1 1 1 0 SUR7/PalI family Ribosomal_L38e PF01781.18 EEA06742.1 - 2.3e-29 101.3 1.7 2.6e-29 101.1 1.7 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family TPR_2 PF07719.17 EEA06743.1 - 3.6e-16 57.9 11.0 0.0011 18.9 0.4 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat SRP72 PF08492.12 EEA06743.1 - 4.1e-15 55.9 2.2 4.1e-15 55.9 2.2 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 EEA06743.1 - 3.6e-13 49.5 0.6 3.6e-13 49.5 0.6 4.1 2 1 1 4 4 4 1 Putative TPR-like repeat TPR_1 PF00515.28 EEA06743.1 - 2.3e-12 46.2 18.3 0.016 15.0 1.3 7.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06743.1 - 4.4e-08 33.3 1.8 5.5 7.3 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA06743.1 - 4.5e-06 27.1 0.6 4.5 7.9 0.1 5.1 4 1 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA06743.1 - 3.7e-05 23.9 18.9 6.1e-05 23.2 1.4 5.2 3 2 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EEA06743.1 - 4.9e-05 23.1 0.2 2.2 8.5 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.8 EEA06743.1 - 0.00048 19.2 7.3 0.011 14.6 0.3 3.1 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EEA06743.1 - 0.00065 20.2 2.3 22 6.0 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA06743.1 - 0.00071 19.6 17.5 0.044 14.0 0.7 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06743.1 - 0.0017 18.0 0.2 54 3.6 0.0 5.6 6 0 0 6 6 6 0 TPR repeat TPR_9 PF13371.6 EEA06743.1 - 0.0073 16.4 0.1 0.11 12.7 0.0 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 EEA06743.1 - 0.034 14.1 5.7 0.14 12.2 0.4 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EEA06743.1 - 0.48 10.5 3.1 16 5.6 0.1 3.7 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ArsA_ATPase PF02374.15 EEA06744.1 - 7.4e-92 307.8 0.1 2e-81 273.6 0.0 2.1 2 0 0 2 2 2 2 Anion-transporting ATPase CbiA PF01656.23 EEA06744.1 - 7.1e-10 39.0 0.0 3.3e-09 36.9 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EEA06744.1 - 2.2e-09 37.5 0.2 1.2e-08 35.1 0.0 2.3 2 2 0 3 3 3 1 AAA domain Fer4_NifH PF00142.18 EEA06744.1 - 3.1e-05 23.6 0.0 4.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EEA06744.1 - 3.2e-05 23.5 0.9 0.00038 20.0 0.1 2.2 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EEA06744.1 - 0.0017 18.0 0.0 0.0047 16.6 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EEA06744.1 - 0.0052 16.3 0.0 0.043 13.3 0.0 2.1 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ NB-ARC PF00931.22 EEA06744.1 - 0.015 14.5 0.0 0.027 13.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EEA06744.1 - 0.015 14.6 0.0 0.053 12.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin APS_kinase PF01583.20 EEA06744.1 - 0.16 11.9 0.1 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase Thioredoxin PF00085.20 EEA06745.1 - 1.4e-50 169.6 0.0 8.9e-28 96.3 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 EEA06745.1 - 1.5e-08 34.3 0.2 6.8e-07 28.9 0.0 2.7 3 0 0 3 3 3 1 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 EEA06745.1 - 3.9e-08 33.4 0.1 0.00057 19.9 0.1 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EEA06745.1 - 1.2e-06 28.9 1.1 0.046 14.2 0.1 4.3 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EEA06745.1 - 3.8e-06 27.1 0.1 0.033 14.5 0.0 4.2 2 2 1 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 EEA06745.1 - 7.4e-06 25.9 0.1 0.15 12.0 0.0 2.6 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EEA06745.1 - 0.00023 21.3 0.0 1.2 9.3 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.6 EEA06745.1 - 0.001 18.9 0.0 0.2 11.4 0.0 2.6 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_4 PF13462.6 EEA06745.1 - 0.0016 18.6 2.7 1 9.5 1.4 3.3 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 EEA06745.1 - 0.029 14.4 0.0 2.1 8.4 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin domain TraF PF13728.6 EEA06745.1 - 0.056 13.3 0.0 0.71 9.6 0.0 2.3 2 0 0 2 2 2 0 F plasmid transfer operon protein DSBA PF01323.20 EEA06745.1 - 0.16 11.7 0.1 5.9 6.6 0.0 2.6 2 1 1 3 3 3 0 DSBA-like thioredoxin domain CLASP_N PF12348.8 EEA06746.1 - 2.1e-05 24.2 2.6 7.1e-05 22.5 2.6 1.9 1 1 0 1 1 1 1 CLASP N terminal RINGv PF12906.7 EEA06747.1 - 1.6e-11 44.1 2.9 5.7e-11 42.4 2.9 2.1 1 0 0 1 1 1 1 RING-variant domain FHA PF00498.26 EEA06747.1 - 2.7e-06 27.6 0.3 0.00016 21.9 0.1 3.2 2 0 0 2 2 2 1 FHA domain Pestivirus_E2 PF16329.5 EEA06747.1 - 0.032 13.1 0.2 0.06 12.2 0.2 1.4 1 0 0 1 1 1 0 Pestivirus envelope glycoprotein E2 Yop-YscD_cpl PF16697.5 EEA06747.1 - 0.044 14.1 0.0 0.48 10.8 0.0 2.5 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain TT_ORF1 PF02956.14 EEA06747.1 - 4.9 5.7 8.4 0.074 11.7 0.2 2.0 3 0 0 3 3 3 0 TT viral orf 1 Opiods_neuropep PF01160.18 EEA06747.1 - 8.1 6.6 8.5 1.1 9.4 3.0 2.5 3 0 0 3 3 3 0 Vertebrate endogenous opioids neuropeptide BING4CT PF08149.11 EEA06748.1 - 3.2e-35 119.8 0.0 1.2e-31 108.3 0.0 2.8 2 0 0 2 2 2 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EEA06748.1 - 9.7e-06 25.8 0.0 2.3 8.6 0.0 3.8 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA06748.1 - 1.2e-05 25.9 3.2 0.72 10.8 0.1 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat WD40_like PF17005.5 EEA06748.1 - 0.0095 15.3 0.2 0.027 13.8 0.1 1.8 2 0 0 2 2 2 1 WD40-like domain Ricin_B_lectin PF00652.22 EEA06749.1 - 8.5e-06 26.0 0.3 3.6e-05 24.0 0.2 1.9 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Methyltr_RsmB-F PF01189.17 EEA06750.1 - 3.6e-20 72.4 0.0 8.6e-12 45.1 0.1 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F MTS PF05175.14 EEA06750.1 - 0.018 14.6 0.1 0.036 13.6 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain WD40 PF00400.32 EEA06751.1 - 2.7e-20 72.3 12.0 2.2e-05 25.1 0.3 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06751.1 - 1.2e-12 48.0 1.3 0.00036 20.8 0.2 5.4 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA06751.1 - 1.3e-06 28.5 0.0 0.00035 20.5 0.0 2.7 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PP2C PF00481.21 EEA06752.1 - 5.8e-21 75.3 0.0 9.5e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EEA06752.1 - 0.0025 17.5 0.0 0.015 15.0 0.0 2.0 2 0 0 2 2 2 1 Protein phosphatase 2C Glycos_transf_2 PF00535.26 EEA06753.1 - 2.1e-23 83.0 0.0 3.4e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EEA06753.1 - 1.5e-11 44.7 5.0 3.2e-08 33.9 0.3 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 EEA06753.1 - 1.2e-05 24.9 0.2 4e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 EEA06753.1 - 1.9e-05 25.3 0.2 0.001 19.8 0.0 2.4 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_3 PF13641.6 EEA06753.1 - 0.00036 20.5 0.0 0.0011 18.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 TRP PF06011.12 EEA06753.1 - 0.076 11.7 0.1 0.12 11.1 0.1 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel zf-RING_2 PF13639.6 EEA06754.1 - 1.3e-12 47.8 7.1 2.4e-12 47.0 7.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EEA06754.1 - 2.6e-07 30.8 7.2 8.5e-07 29.2 7.2 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EEA06754.1 - 8.6e-07 28.6 4.6 8.6e-07 28.6 4.6 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA06754.1 - 2.8e-06 27.0 5.7 5.1e-06 26.2 5.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA06754.1 - 5.6e-06 26.2 4.2 9.8e-06 25.4 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA06754.1 - 2.8e-05 23.9 5.0 7.5e-05 22.5 5.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA06754.1 - 3.1e-05 23.7 7.2 0.0017 18.1 7.6 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EEA06754.1 - 0.00016 21.6 3.2 0.00023 21.1 0.9 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA06754.1 - 0.00028 20.7 6.1 0.00058 19.7 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA06754.1 - 0.00055 19.9 0.8 0.00055 19.9 0.8 2.0 3 0 0 3 3 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EEA06754.1 - 0.00064 19.3 3.9 0.0018 17.8 3.9 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Baculo_RING PF05883.11 EEA06754.1 - 0.0015 18.5 2.0 0.0026 17.7 2.0 1.3 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain RINGv PF12906.7 EEA06754.1 - 0.0099 16.0 5.7 0.02 15.0 5.7 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_4 PF14570.6 EEA06754.1 - 0.012 15.4 6.6 0.024 14.4 6.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EEA06754.1 - 0.026 14.7 4.9 0.11 12.7 4.9 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3H2C3 PF17122.5 EEA06754.1 - 6.3 6.9 7.7 1.1 9.4 1.8 2.5 2 0 0 2 2 2 0 Zinc-finger Clat_adaptor_s PF01217.20 EEA06755.1 - 1.2e-12 48.0 1.7 1.5e-12 47.6 1.7 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain UPF0220 PF05255.11 EEA06755.1 - 0.026 14.1 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) Cation_ATPase_C PF00689.21 EEA06756.1 - 3.9e-50 170.1 6.0 3.9e-50 170.1 6.0 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EEA06756.1 - 9e-50 168.7 0.9 9e-50 168.7 0.9 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EEA06756.1 - 9.3e-22 78.3 0.0 6.4e-12 46.2 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA06756.1 - 7.7e-16 58.0 0.1 7.7e-16 58.0 0.1 2.3 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EEA06756.1 - 9.3e-13 47.7 0.0 3.2e-12 46.0 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EEA06756.1 - 0.00038 20.3 1.2 0.0097 15.7 0.8 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA06756.1 - 0.039 14.4 0.0 0.37 11.2 0.0 2.6 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase RNA_pol_Rpb4 PF03874.16 EEA06757.1 - 3.6e-14 53.1 0.4 4.5e-14 52.8 0.4 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 SecE PF00584.20 EEA06758.1 - 7.4e-11 41.8 0.0 9.4e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Cpn60_TCP1 PF00118.24 EEA06759.1 - 2.7e-161 537.5 1.6 3.1e-161 537.3 1.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Band_7 PF01145.25 EEA06761.1 - 8.9e-26 91.0 3.2 1.9e-25 89.9 3.2 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EEA06761.1 - 2.7e-07 30.0 0.4 3.7e-07 29.5 0.4 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial DUF4290 PF14123.6 EEA06761.1 - 0.026 14.1 0.2 0.037 13.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) NIF PF03031.18 EEA06762.1 - 2.2e-24 86.0 0.0 3.9e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EEA06762.1 - 1.9e-07 31.4 0.5 2e-06 28.1 0.5 2.5 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EEA06762.1 - 4.5e-06 26.5 0.2 2e-05 24.4 0.1 2.2 3 0 0 3 3 3 1 twin BRCT domain LIG3_BRCT PF16759.5 EEA06762.1 - 0.0025 18.1 0.2 0.0071 16.6 0.2 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 EEA06762.1 - 0.1 13.0 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain His_Phos_1 PF00300.22 EEA06764.1 - 5.6e-37 127.3 0.0 2.1e-29 102.6 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) SMN PF06003.12 EEA06765.1 - 2.8e-06 26.8 0.2 4.5e-06 26.1 0.2 1.4 1 1 0 1 1 1 1 Survival motor neuron protein (SMN) DUF3159 PF11361.8 EEA06767.1 - 0.029 14.1 0.2 0.41 10.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3159) zf-C2H2_11 PF16622.5 EEA06768.1 - 0.0034 17.1 0.1 0.0066 16.2 0.1 1.4 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EEA06768.1 - 0.11 13.4 0.1 0.3 12.0 0.1 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger DivIVA PF05103.13 EEA06768.1 - 0.16 12.1 2.2 0.6 10.2 0.1 2.7 2 1 1 3 3 3 0 DivIVA protein zf-C2H2 PF00096.26 EEA06768.1 - 0.2 12.2 0.1 0.53 10.8 0.1 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type CAP PF00188.26 EEA06769.1 - 9.4e-43 146.0 3.7 4e-10 40.6 0.1 4.7 4 0 0 4 4 4 4 Cysteine-rich secretory protein family rRNA_processing PF08524.11 EEA06772.1 - 1.6 8.8 7.1 10 6.1 0.7 2.2 2 0 0 2 2 2 0 rRNA processing RapH_N PF18801.1 EEA06773.1 - 0.045 13.8 0.1 0.25 11.5 0.1 2.3 1 0 0 1 1 1 0 response regulator aspartate phosphatase H, N terminal Myosin_head PF00063.21 EEA06774.1 - 1.8e-176 588.3 24.9 2.6e-176 587.8 24.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) RCC1_2 PF13540.6 EEA06774.1 - 1.9e-31 107.2 12.9 4.1e-09 36.0 0.0 5.5 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EEA06774.1 - 2.7e-28 98.3 4.6 2.4e-07 31.3 0.1 7.2 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EEA06774.1 - 1.6e-11 42.9 36.5 0.00053 19.6 0.1 7.0 6 0 0 6 6 6 6 IQ calmodulin-binding motif AAA_22 PF13401.6 EEA06774.1 - 0.0048 17.2 0.0 0.017 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA06774.1 - 0.021 15.2 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 EEA06774.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF3895 PF13034.6 EEA06774.1 - 0.094 12.7 0.4 3.2 7.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3895) Glutaredoxin PF00462.24 EEA06775.1 - 0.0017 18.5 1.2 0.025 14.8 0.0 3.0 3 1 0 3 3 3 1 Glutaredoxin zinc_ribbon_9 PF14369.6 EEA06775.1 - 0.57 10.5 2.1 1.3 9.3 2.0 1.6 1 1 0 1 1 1 0 zinc-ribbon RNA_pol_L_2 PF13656.6 EEA06776.1 - 2.2e-25 88.2 0.1 2.8e-25 87.9 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EEA06776.1 - 7.1e-07 28.6 0.1 2.2e-06 27.0 0.1 1.8 1 1 1 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Ras PF00071.22 EEA06777.1 - 2.1e-50 170.5 0.0 2.6e-50 170.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA06777.1 - 5.8e-31 107.2 0.0 1.1e-30 106.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA06777.1 - 1.7e-13 50.4 0.0 2.3e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA06777.1 - 1.6e-05 24.4 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA06777.1 - 9.6e-05 22.4 0.0 0.00033 20.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA06777.1 - 0.0011 18.5 0.0 0.0025 17.4 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EEA06777.1 - 0.012 15.1 0.0 0.033 13.6 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EEA06777.1 - 0.06 12.7 0.0 0.17 11.2 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein Nudc_N PF14050.6 EEA06778.1 - 9.6e-15 54.3 0.6 2e-14 53.3 0.6 1.6 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.16 EEA06778.1 - 1.2e-12 48.7 2.7 2.5e-12 47.6 2.7 1.6 1 0 0 1 1 1 1 CS domain ATP-grasp_3 PF02655.14 EEA06778.1 - 0.14 12.2 1.0 0.24 11.5 0.1 1.9 3 0 0 3 3 3 0 ATP-grasp domain WD40 PF00400.32 EEA06779.1 - 4.8e-19 68.3 0.3 9.7e-07 29.4 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat WD40_4 PF16300.5 EEA06779.1 - 1.5e-15 56.8 0.1 3.2e-15 55.7 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.11 EEA06779.1 - 7.9e-12 44.9 0.1 2.3e-11 43.4 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EEA06779.1 - 3.6e-08 33.6 0.4 9.1e-05 22.7 0.1 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA06779.1 - 0.00088 18.0 0.1 0.0024 16.6 0.1 1.6 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EEA06779.1 - 0.0037 16.3 0.8 0.55 9.1 0.0 2.8 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PSII_BNR PF14870.6 EEA06779.1 - 0.0093 15.3 0.5 0.013 14.8 0.5 1.2 1 0 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 PKcGMP_CC PF16808.5 EEA06779.1 - 0.097 12.5 0.4 0.31 10.9 0.4 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YmzC PF14157.6 EEA06779.1 - 0.24 11.5 0.5 22 5.2 0.0 3.2 3 0 0 3 3 3 0 YmzC-like protein DUF1115 PF06544.12 EEA06780.1 - 3.9e-13 49.7 0.2 2.7e-12 47.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Sec34 PF04136.15 EEA06780.1 - 0.041 13.7 0.9 0.041 13.7 0.9 1.8 2 0 0 2 2 2 0 Sec34-like family DUF4515 PF14988.6 EEA06780.1 - 0.053 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) Metallophos PF00149.28 EEA06781.1 - 5.1e-16 59.8 4.5 5.1e-16 59.8 4.5 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glycos_transf_2 PF00535.26 EEA06782.1 - 3.8e-08 33.3 0.1 8.9e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EEA06782.1 - 4.3e-05 23.5 0.0 5.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EEA06782.1 - 0.0026 17.3 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Latarcin PF10279.9 EEA06782.1 - 0.87 10.0 2.9 3.9 8.0 1.6 2.4 2 1 0 2 2 2 0 Latarcin precursor EF1G PF00647.19 EEA06783.1 - 4e-36 123.3 0.0 7.1e-36 122.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EEA06783.1 - 8.6e-05 22.7 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EEA06783.1 - 0.004 17.1 0.0 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EEA06783.1 - 0.019 15.1 0.0 0.04 14.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribosomal_L6e PF01159.19 EEA06784.1 - 2.9e-34 117.9 0.4 4.7e-34 117.2 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L6e DSPn PF14671.6 EEA06785.1 - 1.2e-43 149.0 0.1 1.2e-43 149.0 0.1 2.4 4 0 0 4 4 4 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EEA06785.1 - 7e-18 64.7 0.0 1e-10 41.6 0.0 2.6 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EEA06785.1 - 1.8e-05 24.9 0.1 0.0014 18.8 0.0 2.3 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EEA06785.1 - 2e-05 24.3 0.0 0.0012 18.5 0.0 2.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EEA06785.1 - 0.012 15.6 0.1 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family RRM_1 PF00076.22 EEA06786.1 - 6.9e-30 102.7 1.0 4e-16 58.6 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA06786.1 - 0.0073 16.4 0.0 0.62 10.2 0.0 2.6 2 1 0 2 2 2 1 RNA recognition motif RL PF17797.1 EEA06786.1 - 0.0097 15.8 0.8 0.46 10.5 0.0 3.0 3 0 0 3 3 3 1 RL domain PhetRS_B1 PF18262.1 EEA06786.1 - 0.065 13.5 0.0 8 6.8 0.0 2.5 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain PHM7_cyt PF14703.6 EEA06786.1 - 0.071 13.3 0.1 5.2 7.3 0.0 3.3 2 2 2 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Methyltransf_2 PF00891.18 EEA06786.1 - 0.16 11.2 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain ABC_tran PF00005.27 EEA06791.1 - 3.9e-52 176.4 0.0 8.3e-30 104.1 0.0 2.9 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA06791.1 - 6.1e-43 147.4 28.3 7.6e-32 111.0 6.2 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA06791.1 - 5.3e-10 39.1 0.7 0.0036 16.8 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA06791.1 - 1.2e-05 24.9 0.6 0.014 15.1 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA06791.1 - 0.0015 18.6 0.5 0.16 12.1 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF1691 PF07950.11 EEA06791.1 - 0.02 15.6 0.2 0.082 13.6 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1691) AAA_21 PF13304.6 EEA06791.1 - 0.023 14.5 5.5 4.8 6.9 0.7 3.4 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EEA06791.1 - 0.042 13.9 2.9 0.42 10.7 0.0 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EEA06791.1 - 0.042 13.7 1.4 9.6 6.1 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase cobW PF02492.19 EEA06791.1 - 0.061 12.9 0.9 0.26 10.8 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EEA06791.1 - 0.092 13.2 5.8 3.7 8.0 0.3 2.8 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EEA06791.1 - 0.15 12.4 0.6 11 6.4 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 EEA06791.1 - 3.6 7.6 4.7 30 4.6 0.2 3.1 3 0 0 3 3 3 0 Dynamin family ABC_tran PF00005.27 EEA06792.1 - 1.4e-52 177.9 0.0 3.1e-32 112.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EEA06792.1 - 3.7e-36 125.2 40.4 4.2e-25 88.9 15.9 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA06792.1 - 8.9e-12 44.9 6.7 0.0037 16.7 0.1 4.4 3 1 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA06792.1 - 8.7e-06 25.4 0.6 0.06 13.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA06792.1 - 0.0027 17.8 0.3 0.13 12.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.17 EEA06792.1 - 0.037 14.1 2.9 0.065 13.3 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EEA06792.1 - 0.091 12.7 0.5 18 5.2 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase AAA_16 PF13191.6 EEA06792.1 - 0.11 12.9 0.1 11 6.4 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 EEA06792.1 - 0.24 11.9 1.0 4.8 7.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain PRIMA1 PF16101.5 EEA06792.1 - 0.49 10.4 2.9 5.3 7.1 0.4 2.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF1474 PF07342.11 EEA06793.1 - 0.1 13.2 0.5 1.1 9.8 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) Spermine_synth PF01564.17 EEA06793.1 - 0.1 12.0 0.0 0.98 8.8 0.0 2.3 2 0 0 2 2 2 0 Spermine/spermidine synthase domain ISP3_C PF18045.1 EEA06794.1 - 3.2e-25 88.2 0.2 4.2e-25 87.8 0.2 1.1 1 0 0 1 1 1 1 ISP3 C-terminal ISP1_C PF18161.1 EEA06794.1 - 3.6e-22 78.4 0.3 4.9e-22 78.0 0.3 1.2 1 0 0 1 1 1 1 ISP1 C-terminal ubiquitin PF00240.23 EEA06795.1 - 1.9e-24 85.2 0.9 2.1e-24 85.1 0.9 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA06795.1 - 1.1e-13 50.8 0.8 1.2e-13 50.7 0.8 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA06795.1 - 0.00012 22.4 0.3 0.00033 21.1 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA06795.1 - 0.00078 19.5 0.1 0.0016 18.5 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EEA06795.1 - 0.0011 19.3 0.3 0.0013 19.1 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 EEA06795.1 - 0.029 14.9 0.0 0.033 14.8 0.0 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Big_5 PF13205.6 EEA06796.1 - 6.1e-11 43.0 0.0 7.6e-07 29.8 0.0 3.4 2 1 0 2 2 2 2 Bacterial Ig-like domain Toluene_X PF03349.16 EEA06796.1 - 0.043 12.4 0.0 0.07 11.7 0.0 1.2 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) Snf7 PF03357.21 EEA06797.1 - 4.1e-15 55.8 15.6 5.3e-15 55.4 15.5 1.2 1 1 0 1 1 1 1 Snf7 YlqD PF11068.8 EEA06797.1 - 0.0089 16.4 5.7 0.0089 16.4 5.7 2.5 1 1 2 3 3 3 1 YlqD protein SpoIIE PF07228.12 EEA06797.1 - 0.12 12.3 0.5 0.32 10.9 0.0 1.8 1 1 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Spc24 PF08286.11 EEA06797.1 - 2.8 8.2 21.8 0.24 11.6 6.6 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ISG65-75 PF11727.8 EEA06797.1 - 3.1 7.0 8.1 2.9 7.0 0.8 2.2 2 0 0 2 2 2 0 Invariant surface glycoprotein eIF-4B PF06273.11 EEA06797.1 - 4.2 6.3 7.3 1.2 8.1 4.4 1.5 1 1 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B LSM PF01423.22 EEA06798.1 - 7.5e-18 64.0 0.7 1.4e-17 63.2 0.7 1.4 1 1 0 1 1 1 1 LSM domain DUF4062 PF13271.6 EEA06798.1 - 0.13 12.7 0.0 0.66 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) Methyltrn_RNA_3 PF02598.17 EEA06799.1 - 2.4e-97 325.9 0.0 2.8e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase DEAD PF00270.29 EEA06800.1 - 1.2e-37 129.4 0.0 1.7e-35 122.4 0.0 3.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA06800.1 - 1.3e-32 112.4 0.0 7.1e-32 110.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA06800.1 - 1e-05 25.6 0.0 2.8e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EEA06800.1 - 0.015 14.1 0.0 2.2 6.9 0.0 2.4 3 0 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 SecA_DEAD PF07517.14 EEA06800.1 - 0.02 14.2 0.0 0.058 12.7 0.0 1.7 2 0 0 2 2 2 0 SecA DEAD-like domain zf-CCHC_4 PF14392.6 EEA06800.1 - 0.26 11.0 1.7 2 8.2 0.9 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EEA06800.1 - 0.37 11.0 2.7 0.68 10.1 2.7 1.5 1 0 0 1 1 1 0 Zinc knuckle Cyclin_N PF00134.23 EEA06801.1 - 2.4e-06 27.3 0.2 6.2e-06 26.0 0.2 1.7 1 1 0 1 1 1 1 Cyclin, N-terminal domain Rep_fac-A_C PF08646.10 EEA06802.1 - 1.5e-26 92.9 0.6 3.6e-25 88.4 0.1 2.6 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EEA06802.1 - 2.4e-22 78.7 0.1 7.8e-20 70.6 0.0 2.6 2 0 0 2 2 2 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 EEA06802.1 - 3e-12 46.3 0.3 1e-09 38.3 0.1 3.6 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 EEA06802.1 - 4e-05 23.8 0.1 0.00015 22.0 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function DUF223 Sgf11 PF08209.11 EEA06802.1 - 0.12 11.9 1.8 3.7 7.2 0.1 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Prefoldin_2 PF01920.20 EEA06803.1 - 6.8e-21 74.2 9.5 8.5e-21 73.9 9.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit Spc7 PF08317.11 EEA06803.1 - 8.4e-05 21.6 5.6 0.012 14.5 1.0 2.0 2 0 0 2 2 2 2 Spc7 kinetochore protein APG6_N PF17675.1 EEA06803.1 - 0.00051 20.6 7.7 0.0039 17.7 1.2 2.1 2 0 0 2 2 2 1 Apg6 coiled-coil region FlxA PF14282.6 EEA06803.1 - 0.00057 19.8 7.7 0.027 14.4 1.3 2.2 2 0 0 2 2 2 2 FlxA-like protein SlyX PF04102.12 EEA06803.1 - 0.0013 19.3 1.6 1.1 9.9 0.3 2.2 2 0 0 2 2 2 1 SlyX Laminin_I PF06008.14 EEA06803.1 - 0.0017 18.2 6.7 0.027 14.2 1.0 2.0 1 1 1 2 2 2 1 Laminin Domain I Mod_r PF07200.13 EEA06803.1 - 0.0018 18.4 3.6 0.0043 17.2 3.6 1.6 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein ATP-synt_D PF01813.17 EEA06803.1 - 0.0033 17.3 2.0 0.066 13.0 0.2 2.0 2 0 0 2 2 2 1 ATP synthase subunit D TelA PF05816.11 EEA06803.1 - 0.0053 15.9 2.7 0.0064 15.6 2.7 1.1 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DivIC PF04977.15 EEA06803.1 - 0.0057 16.4 4.3 0.85 9.4 0.2 2.2 2 0 0 2 2 2 2 Septum formation initiator E2F_CC-MB PF16421.5 EEA06803.1 - 0.011 16.0 3.9 0.62 10.5 0.3 2.1 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain DUF4140 PF13600.6 EEA06803.1 - 0.012 16.1 0.9 1.2 9.6 0.1 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ABC_tran_CTD PF16326.5 EEA06803.1 - 0.013 15.8 7.4 0.2 11.9 1.6 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain TACC_C PF05010.14 EEA06803.1 - 0.013 15.3 8.0 0.11 12.3 8.2 1.8 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal OmpH PF03938.14 EEA06803.1 - 0.015 15.7 2.6 0.19 12.0 0.2 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF816 PF05674.12 EEA06803.1 - 0.017 15.1 0.6 0.038 13.9 0.6 1.6 1 1 0 1 1 1 0 Baculovirus protein of unknown function (DUF816) FliD_C PF07195.12 EEA06803.1 - 0.018 14.5 1.5 0.15 11.5 0.1 2.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus CLZ PF16526.5 EEA06803.1 - 0.018 15.4 5.0 1.5 9.2 0.4 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Prefoldin PF02996.17 EEA06803.1 - 0.018 14.9 1.5 0.018 14.9 1.5 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF5104 PF17117.5 EEA06803.1 - 0.023 15.1 2.0 0.19 12.2 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) Tropomyosin_1 PF12718.7 EEA06803.1 - 0.024 14.8 8.1 0.53 10.4 1.5 2.1 2 0 0 2 2 2 0 Tropomyosin like DUF2802 PF10975.8 EEA06803.1 - 0.028 14.5 1.3 2.4 8.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) DUF1664 PF07889.12 EEA06803.1 - 0.031 14.3 2.4 0.62 10.1 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) STAT_alpha PF01017.20 EEA06803.1 - 0.034 14.0 3.0 0.041 13.8 3.0 1.1 1 0 0 1 1 1 0 STAT protein, all-alpha domain BRE1 PF08647.11 EEA06803.1 - 0.037 14.1 7.9 0.1 12.7 1.4 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3086 PF11285.8 EEA06803.1 - 0.041 13.0 0.1 0.041 13.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) HAUS4 PF14735.6 EEA06803.1 - 0.045 13.4 3.5 2.2 7.9 0.4 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 TPR_MLP1_2 PF07926.12 EEA06803.1 - 0.054 13.6 6.9 0.38 10.8 1.5 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 EEA06803.1 - 0.054 13.5 12.0 0.44 10.6 2.0 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4600 PF15372.6 EEA06803.1 - 0.054 13.9 6.5 0.18 12.2 6.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) Occludin_ELL PF07303.13 EEA06803.1 - 0.057 14.1 3.1 2.5 8.9 0.2 2.1 2 0 0 2 2 2 0 Occludin homology domain DUF5320 PF17253.2 EEA06803.1 - 0.058 14.5 0.2 0.058 14.5 0.2 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5320) CALCOCO1 PF07888.11 EEA06803.1 - 0.063 12.1 5.6 0.22 10.4 5.6 1.7 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Snf7 PF03357.21 EEA06803.1 - 0.068 12.8 5.4 0.18 11.4 0.5 2.0 2 0 0 2 2 2 0 Snf7 HJURP_C PF12347.8 EEA06803.1 - 0.075 13.1 0.4 0.14 12.2 0.1 1.6 2 0 0 2 2 1 0 Holliday junction regulator protein family C-terminal repeat GrpE PF01025.19 EEA06803.1 - 0.081 12.6 7.8 0.22 11.2 1.1 2.1 2 0 0 2 2 2 0 GrpE Spc24 PF08286.11 EEA06803.1 - 0.092 13.0 10.1 0.63 10.3 2.2 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 PEP-utilisers_N PF05524.13 EEA06803.1 - 0.097 12.8 0.3 0.3 11.2 0.0 1.8 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Rho_Binding PF08912.11 EEA06803.1 - 0.098 13.5 7.6 1.3 9.9 0.7 2.2 2 0 0 2 2 2 0 Rho Binding HMMR_N PF15905.5 EEA06803.1 - 0.11 12.0 10.0 0.19 11.2 10.0 1.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Helo_like_N PF17111.5 EEA06803.1 - 0.11 11.8 6.1 0.25 10.7 0.6 2.0 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins BRI3BP PF14965.6 EEA06803.1 - 0.14 11.6 1.4 5.4 6.5 0.2 2.1 2 0 0 2 2 2 0 Negative regulator of p53/TP53 ZapB PF06005.12 EEA06803.1 - 0.15 12.5 6.5 0.71 10.4 0.6 2.2 2 0 0 2 2 2 0 Cell division protein ZapB End3 PF12761.7 EEA06803.1 - 0.15 12.2 8.0 0.61 10.2 1.3 2.0 1 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 CENP-F_leu_zip PF10473.9 EEA06803.1 - 0.17 11.9 8.7 1 9.4 1.2 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Med4 PF10018.9 EEA06803.1 - 0.19 11.4 7.4 0.47 10.1 0.9 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4200 PF13863.6 EEA06803.1 - 0.23 11.9 7.8 1.2 9.6 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) FapA PF03961.13 EEA06803.1 - 0.23 10.0 7.9 0.44 9.1 7.9 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF724 PF05266.14 EEA06803.1 - 0.26 11.1 5.4 0.65 9.8 5.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 EEA06803.1 - 0.29 10.4 3.4 1 8.6 3.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EEA06803.1 - 0.36 11.0 6.0 0.67 10.1 5.9 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF5082 PF16888.5 EEA06803.1 - 0.37 11.1 8.3 0.96 9.7 1.2 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) IFT57 PF10498.9 EEA06803.1 - 0.41 9.6 8.3 0.16 10.9 1.6 1.9 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 V_ATPase_I PF01496.19 EEA06803.1 - 0.41 8.5 4.2 0.15 9.9 0.6 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family bZIP_1 PF00170.21 EEA06803.1 - 0.42 10.8 9.9 1.7 8.8 2.3 2.5 2 1 0 2 2 2 0 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 EEA06803.1 - 0.48 10.6 9.2 0.46 10.7 2.0 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF948 PF06103.11 EEA06803.1 - 0.5 10.7 2.1 4.2 7.7 0.1 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ACCA PF03255.14 EEA06803.1 - 0.53 10.2 3.7 5.1 7.0 0.7 2.1 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Syntaxin_2 PF14523.6 EEA06803.1 - 0.54 10.7 6.7 16 5.9 6.7 2.2 1 1 0 1 1 1 0 Syntaxin-like protein Syntaxin-6_N PF09177.11 EEA06803.1 - 0.57 10.8 6.0 0.31 11.6 0.9 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal AKNA PF12443.8 EEA06803.1 - 0.7 10.6 5.0 1.1 10.0 0.6 2.1 2 0 0 2 2 2 0 AT-hook-containing transcription factor XhlA PF10779.9 EEA06803.1 - 0.72 10.1 7.8 1.9 8.7 0.8 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DHR10 PF18595.1 EEA06803.1 - 0.74 9.9 8.4 28 4.8 8.4 2.2 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF4665 PF15679.5 EEA06803.1 - 0.91 10.2 5.3 1.4 9.6 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) DUF4618 PF15397.6 EEA06803.1 - 0.93 8.9 9.2 40 3.5 9.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Ax_dynein_light PF10211.9 EEA06803.1 - 1.3 8.9 10.6 0.55 10.2 2.8 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain DUF16 PF01519.16 EEA06803.1 - 1.5 9.3 7.0 2.1 8.8 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Seryl_tRNA_N PF02403.22 EEA06803.1 - 1.8 8.9 10.3 6.4 7.0 2.8 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Swi5 PF07061.11 EEA06803.1 - 1.9 8.6 9.2 1.6 8.9 1.4 2.6 1 1 1 2 2 2 0 Swi5 bZIP_2 PF07716.15 EEA06803.1 - 9 6.5 9.3 5.7 7.1 1.8 2.4 2 1 0 2 2 2 0 Basic region leucine zipper PP2C PF00481.21 EEA06804.1 - 2.9e-14 53.3 0.8 1.5e-06 28.1 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EEA06804.1 - 9.2e-13 48.5 0.0 1.5e-12 47.8 0.0 1.3 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EEA06804.1 - 6.3e-09 35.8 0.0 8.7e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C ILEI PF15711.5 EEA06804.1 - 0.0034 17.8 0.0 0.016 15.7 0.0 2.1 2 0 0 2 2 2 1 Interleukin-like EMT inducer EntA_Immun PF08951.10 EEA06804.1 - 0.061 13.7 1.2 2.6 8.5 0.2 2.4 2 0 0 2 2 2 0 Enterocin A Immunity Rpp20 PF12328.8 EEA06805.1 - 4e-17 62.5 0.0 5.5e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EEA06805.1 - 1.2e-12 47.5 0.1 2.1e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Alba Lar_N PF09861.9 EEA06806.1 - 0.16 11.1 0.4 0.27 10.4 0.4 1.3 1 0 0 1 1 1 0 Lactate racemase N-terminal domain AAA PF00004.29 EEA06809.1 - 2.6e-12 47.3 0.0 5.8e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EEA06809.1 - 5.1e-07 29.8 0.0 2.1e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_14 PF13173.6 EEA06809.1 - 8.6e-05 22.6 0.5 0.00049 20.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EEA06809.1 - 0.0004 20.9 0.0 0.0018 18.8 0.0 2.1 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EEA06809.1 - 0.0004 20.3 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EEA06809.1 - 0.0013 19.1 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_assoc_2 PF16193.5 EEA06809.1 - 0.0018 18.6 0.0 0.0052 17.1 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_5 PF07728.14 EEA06809.1 - 0.0057 16.7 0.0 0.016 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EEA06809.1 - 0.0078 16.8 0.0 0.04 14.5 0.0 2.3 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 EEA06809.1 - 0.0094 15.8 0.8 0.039 13.8 0.0 2.5 2 1 0 2 2 2 1 Deoxynucleoside kinase ATPase_2 PF01637.18 EEA06809.1 - 0.012 15.6 0.0 0.012 15.6 0.0 2.2 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 EEA06809.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 EEA06809.1 - 0.035 14.4 0.2 0.37 11.1 0.2 2.4 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EEA06809.1 - 0.054 13.9 0.2 0.63 10.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EEA06809.1 - 0.069 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA06809.1 - 0.07 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EEA06809.1 - 0.18 11.6 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Prok-RING_1 PF14446.6 EEA06810.1 - 0.031 14.2 3.9 0.031 14.2 3.9 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 EEA06810.1 - 0.064 13.6 13.8 0.39 11.1 14.0 2.1 1 1 0 1 1 1 0 Ring finger domain C1_1 PF00130.22 EEA06810.1 - 0.16 11.9 6.4 0.63 10.0 4.9 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EEA06810.1 - 0.2 11.6 8.4 0.14 12.1 5.4 2.0 2 0 0 2 2 2 0 PHD-finger RINGv PF12906.7 EEA06810.1 - 0.35 11.0 11.4 0.78 9.9 11.3 1.6 1 1 0 1 1 1 0 RING-variant domain C1_2 PF03107.16 EEA06810.1 - 3.5 8.0 9.4 5.8 7.3 7.1 2.2 2 0 0 2 2 2 0 C1 domain START PF01852.19 EEA06811.1 - 0.013 14.9 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 START domain UBA PF00627.31 EEA06814.1 - 4.7e-25 87.1 7.2 1.4e-13 50.4 0.8 2.5 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 EEA06814.1 - 7.3e-21 73.7 5.6 1.9e-20 72.3 5.6 1.8 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EEA06814.1 - 4.1e-18 64.9 1.2 7.4e-18 64.1 1.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA06814.1 - 2.1e-08 33.9 1.5 3.9e-08 33.0 1.5 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EEA06814.1 - 3.7e-05 24.2 0.4 8e-05 23.1 0.4 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain UBA_3 PF09288.10 EEA06814.1 - 6e-05 22.8 0.0 0.0032 17.2 0.0 2.9 3 0 0 3 3 3 1 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.6 EEA06814.1 - 9.4e-05 22.5 1.6 0.00018 21.6 1.6 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EEA06814.1 - 0.0094 16.0 2.3 0.12 12.5 1.5 2.5 1 1 1 2 2 2 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EEA06814.1 - 0.04 14.3 1.7 0.088 13.2 1.7 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain GDI PF00996.18 EEA06815.1 - 1.1e-34 119.8 0.4 3.8e-18 65.2 0.0 3.9 2 2 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EEA06815.1 - 0.017 15.3 0.0 0.061 13.6 0.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Ribosomal_S4e PF00900.20 EEA06817.1 - 5.3e-29 99.9 0.3 1.4e-28 98.6 0.3 1.8 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.12 EEA06817.1 - 2.1e-20 72.5 3.4 2.1e-20 72.5 3.4 1.8 2 0 0 2 2 2 1 RS4NT (NUC023) domain 40S_S4_C PF16121.5 EEA06817.1 - 5.9e-20 70.6 0.1 9.3e-20 70.0 0.1 1.3 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 EEA06817.1 - 2.9e-07 30.1 0.0 5.2e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EEA06817.1 - 0.0013 18.7 0.3 0.0013 18.7 0.3 2.4 3 0 0 3 3 3 1 KOW motif Sipho_tail PF05709.11 EEA06817.1 - 0.012 15.0 0.0 0.018 14.5 0.0 1.3 1 1 0 1 1 1 0 Phage tail protein RNA_pol_Rpb6 PF01192.22 EEA06818.1 - 1.3e-18 66.6 0.2 2.7e-18 65.6 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb6 GST_C_3 PF14497.6 EEA06819.1 - 0.00036 20.7 0.0 0.00069 19.8 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Scramblase PF03803.15 EEA06820.1 - 0.078 12.3 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 Scramblase Orbi_VP4 PF05059.12 EEA06821.1 - 0.029 12.4 0.0 0.029 12.4 0.0 1.0 1 0 0 1 1 1 0 Orbivirus VP4 core protein Aa_trans PF01490.18 EEA06822.1 - 1e-48 166.0 29.5 1.3e-48 165.8 29.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PA14 PF07691.12 EEA06823.1 - 3.1e-27 95.2 0.0 1.2e-26 93.3 0.0 1.9 2 0 0 2 2 2 1 PA14 domain GLEYA PF10528.9 EEA06823.1 - 0.0014 19.0 0.0 0.0039 17.6 0.0 1.8 1 0 0 1 1 1 1 GLEYA domain fn2 PF00040.19 EEA06823.1 - 0.0066 16.7 1.3 0.015 15.5 1.3 1.6 1 0 0 1 1 1 1 Fibronectin type II domain DUF4559 PF15112.6 EEA06823.1 - 0.051 13.3 5.7 11 5.6 2.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4559) HSBP1 PF06825.12 EEA06823.1 - 0.056 13.3 1.1 0.24 11.3 1.0 2.1 1 1 1 2 2 2 0 Heat shock factor binding protein 1 BLOC1_2 PF10046.9 EEA06823.1 - 0.38 11.1 4.7 0.12 12.7 1.4 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 EEA06823.1 - 0.38 10.8 3.7 0.45 10.5 0.5 2.5 2 1 1 3 3 3 0 Laminin Domain II Cluap1 PF10234.9 EEA06823.1 - 2.4 7.5 6.0 0.46 9.8 2.3 1.6 2 0 0 2 2 2 0 Clusterin-associated protein-1 NBD94 PF16830.5 EEA06823.1 - 3.3 8.2 8.1 8.3 6.9 0.9 3.4 3 1 0 3 3 3 0 Nucleotide-Binding Domain 94 of RH FliJ PF02050.16 EEA06823.1 - 3.6 7.8 5.0 29 4.9 0.2 2.7 3 0 0 3 3 3 0 Flagellar FliJ protein UL45 PF05473.12 EEA06824.1 - 0.057 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like MS_channel PF00924.18 EEA06825.1 - 5.8e-19 68.5 2.3 1.5e-18 67.1 2.3 1.7 1 0 0 1 1 1 1 Mechanosensitive ion channel TMEM43 PF07787.12 EEA06825.1 - 0.019 14.3 0.1 0.019 14.3 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 43 Microtub_bd PF16796.5 EEA06825.1 - 0.2 11.6 1.0 26 4.8 0.0 2.5 2 0 0 2 2 2 0 Microtubule binding Phosducin PF02114.16 EEA06826.1 - 3.4e-07 29.5 0.3 3.4e-07 29.5 0.3 1.4 1 1 1 2 2 2 1 Phosducin DUF1221 PF06760.11 EEA06826.1 - 7.9e-05 22.3 0.3 0.00013 21.6 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1221) Thioredoxin PF00085.20 EEA06826.1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin EF-1_beta_acid PF10587.9 EEA06826.1 - 0.22 12.0 2.2 0.44 11.1 2.2 1.5 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Pkinase PF00069.25 EEA06827.1 - 3.8e-59 200.2 0.1 4.8e-59 199.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06827.1 - 2.3e-31 109.0 0.0 3.2e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EEA06827.1 - 0.00013 21.6 0.5 0.0002 21.0 0.5 1.2 1 0 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.11 EEA06827.1 - 0.00034 19.8 5.1 0.00082 18.5 5.1 1.6 1 1 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 EEA06827.1 - 0.00037 19.6 1.0 0.00054 19.0 1.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain PIP49_C PF12260.8 EEA06827.1 - 0.0006 19.5 0.1 0.0023 17.6 0.1 1.8 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 Kinase-like PF14531.6 EEA06827.1 - 0.0041 16.5 0.2 0.012 14.9 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EEA06827.1 - 0.044 13.1 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EEA06827.1 - 0.064 12.8 0.6 0.097 12.2 0.6 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 EEA06827.1 - 0.11 12.1 1.2 1.2 8.8 0.1 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EEA06827.1 - 0.19 11.6 0.3 0.37 10.7 0.3 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SNCAIP_SNCA_bd PF16700.5 EEA06828.1 - 0.21 11.4 0.3 0.51 10.1 0.3 1.6 1 0 0 1 1 1 0 Synphilin-1 alpha-Synuclein-binding domain Lysis_col PF02402.16 EEA06829.1 - 0.042 13.5 1.2 0.068 12.9 1.2 1.2 1 0 0 1 1 1 0 Lysis protein rRNA_processing PF08524.11 EEA06830.1 - 1.3e-08 35.0 13.9 1.5e-08 34.8 13.9 1.1 1 0 0 1 1 1 1 rRNA processing DUF3010 PF11215.8 EEA06830.1 - 0.022 15.1 0.7 0.025 14.9 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3010) TPR_22 PF18833.1 EEA06832.1 - 0.027 14.6 0.2 0.069 13.3 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4679 PF15728.5 EEA06832.1 - 0.083 11.9 0.2 0.13 11.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) UCH PF00443.29 EEA06833.1 - 1.9e-24 86.6 7.9 1.9e-24 86.6 7.9 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA06833.1 - 3.1e-06 27.0 11.7 3.1e-06 27.0 11.7 2.9 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase NCOA_u2 PF16665.5 EEA06833.1 - 0.08 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein zf-RING_2 PF13639.6 EEA06834.1 - 7.3e-13 48.6 4.1 7.3e-13 48.6 4.1 1.7 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 EEA06834.1 - 2e-10 40.2 3.1 2e-10 40.2 3.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA06834.1 - 2.7e-09 36.7 4.1 5.6e-09 35.7 4.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA06834.1 - 2.2e-08 34.2 5.3 5.4e-08 33.0 5.3 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EEA06834.1 - 2.8e-07 30.3 3.9 5.8e-07 29.3 3.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA06834.1 - 1.4e-06 28.2 4.3 3.1e-06 27.1 4.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA06834.1 - 6.1e-06 26.1 3.1 1.4e-05 24.9 3.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_1 PF14446.6 EEA06834.1 - 0.00055 19.8 2.4 0.00055 19.8 2.4 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-C3HC4_3 PF13920.6 EEA06834.1 - 0.0028 17.5 2.0 0.0058 16.5 2.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA06834.1 - 0.0049 16.9 1.5 0.011 15.7 1.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EEA06834.1 - 0.0093 15.7 2.7 0.018 14.8 2.7 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain DUF997 PF06196.12 EEA06834.1 - 0.01 15.8 5.2 0.01 15.8 5.2 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF997) Zn_ribbon_17 PF17120.5 EEA06834.1 - 0.047 13.3 4.1 0.099 12.3 4.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DHHC PF01529.20 EEA06834.1 - 0.071 13.2 7.4 2.9 8.0 3.6 2.5 2 0 0 2 2 2 0 DHHC palmitoyltransferase FANCL_C PF11793.8 EEA06834.1 - 0.1 12.8 4.0 0.54 10.5 4.0 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EEA06834.1 - 0.36 11.0 4.2 0.78 9.9 4.2 1.6 1 0 0 1 1 1 0 RING-variant domain Alg14 PF08660.11 EEA06836.1 - 1.3e-34 119.6 0.1 1.7e-34 119.3 0.1 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_transf_28 PF03033.20 EEA06836.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Aldedh PF00171.22 EEA06837.1 - 7e-18 64.4 0.5 4.6e-10 38.6 0.2 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 EEA06837.1 - 0.042 13.3 0.1 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Fumble PF03630.14 EEA06838.1 - 1.4e-44 152.7 8.7 7.4e-30 104.2 2.1 2.9 2 1 0 2 2 2 2 Fumble zf-RING_4 PF14570.6 EEA06839.1 - 2.9e-19 68.6 19.4 7.1e-19 67.3 19.4 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EEA06839.1 - 9.2e-08 31.8 0.1 2.4e-07 30.5 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EEA06839.1 - 0.0043 17.3 15.5 0.012 16.0 15.5 1.8 1 0 0 1 1 1 1 Ring finger domain Torus PF16131.5 EEA06839.1 - 0.18 12.5 4.1 0.15 12.8 0.4 2.4 2 0 0 2 2 2 0 Torus domain zf-UDP PF14569.6 EEA06839.1 - 0.44 10.7 6.3 1.3 9.2 6.3 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 EEA06839.1 - 6 6.8 13.0 3 7.8 0.1 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 EF-hand_13 PF17958.1 EEA06840.1 - 7.1e-12 45.0 0.1 2.1e-11 43.5 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EEA06840.1 - 1.5e-09 38.1 4.4 1.8e-07 31.5 4.4 2.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EEA06840.1 - 0.0017 18.2 0.0 0.26 11.3 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain FeoB_Cyto PF17910.1 EEA06840.1 - 0.12 12.9 2.3 2.8 8.6 0.0 2.7 2 0 0 2 2 2 0 FeoB cytosolic helical domain Pkinase_Tyr PF07714.17 EEA06841.1 - 2.5e-41 141.7 0.0 3.5e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EEA06841.1 - 1.4e-38 132.8 0.0 2.2e-38 132.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EEA06841.1 - 0.0035 16.3 1.2 0.012 14.5 0.1 2.0 2 0 0 2 2 2 1 Haspin like kinase domain NopRA1 PF16201.5 EEA06842.1 - 2.3e-16 60.0 0.3 3.8e-15 56.0 0.1 3.3 2 1 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 RRM_1 PF00076.22 EEA06843.1 - 6.7e-18 64.3 0.4 1.6e-17 63.1 0.4 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 EEA06843.1 - 3.8e-08 33.8 0.8 3.8e-08 33.8 0.8 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G DUF4615 PF15393.6 EEA06843.1 - 0.004 17.7 0.1 0.004 17.7 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4615) PHM7_cyt PF14703.6 EEA06843.1 - 0.0092 16.2 3.3 3.1 8.0 0.3 3.0 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter ComGF PF15980.5 EEA06843.1 - 0.081 13.3 0.1 0.081 13.3 0.1 2.1 2 1 0 2 2 2 0 Putative Competence protein ComGF RRM_7 PF16367.5 EEA06843.1 - 0.095 12.8 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM PF05172.13 EEA06843.1 - 0.37 10.8 0.0 0.37 10.8 0.0 2.1 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-MYND PF01753.18 EEA06845.1 - 1.8e-12 47.1 9.6 3.7e-12 46.1 9.5 1.6 1 1 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EEA06845.1 - 0.11 12.8 7.2 0.28 11.5 7.2 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Thioredoxin PF00085.20 EEA06846.1 - 1.7e-28 98.6 0.0 1.2e-18 67.0 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EEA06846.1 - 2.7e-13 50.2 6.7 4.2e-10 39.8 0.9 4.0 2 1 2 4 4 4 2 Thioredoxin-like domain TraF PF13728.6 EEA06846.1 - 6.1e-06 26.2 0.0 0.062 13.1 0.0 2.3 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EEA06846.1 - 0.0004 20.8 0.0 0.11 13.0 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like domain DUF836 PF05768.14 EEA06846.1 - 0.00083 19.7 0.0 0.93 9.9 0.0 2.9 3 0 0 3 3 3 2 Glutaredoxin-like domain (DUF836) Thioredoxin_8 PF13905.6 EEA06846.1 - 0.00085 19.6 0.4 0.27 11.6 0.0 3.7 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EEA06846.1 - 0.0036 17.5 0.0 0.054 13.7 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like Glutaredoxin PF00462.24 EEA06846.1 - 0.026 14.7 0.2 9.1 6.6 0.0 2.5 2 0 0 2 2 2 0 Glutaredoxin Bud13 PF09736.9 EEA06847.1 - 9.5e-32 110.4 0.2 1.2e-31 110.1 0.2 1.0 1 0 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex Tli4_N PF18443.1 EEA06847.1 - 0.17 12.3 0.9 0.51 10.7 0.9 1.8 1 1 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain AP2 PF00847.20 EEA06849.1 - 4.4e-33 113.3 8.9 4.9e-18 65.1 3.3 3.5 3 0 0 3 3 3 2 AP2 domain DUF2951 PF11166.8 EEA06849.1 - 0.024 14.9 1.3 23 5.3 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) Bacillus_HBL PF05791.11 EEA06849.1 - 3.8 7.3 13.9 0.84 9.4 0.4 3.2 4 0 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) WD40 PF00400.32 EEA06850.1 - 4.3e-09 36.8 3.2 0.021 15.7 0.1 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA06850.1 - 2.2e-05 24.7 0.1 0.95 9.8 0.1 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA06850.1 - 0.012 14.6 0.2 0.075 12.0 0.0 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactamase_B_2 PF12706.7 EEA06851.1 - 4e-08 33.0 0.0 0.0058 16.2 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EEA06851.1 - 0.0028 17.7 0.0 0.14 12.2 0.0 2.1 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily DUF4834 PF16118.5 EEA06852.1 - 0.085 13.8 0.0 0.1 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) NUMOD1 PF07453.13 EEA06853.1 - 0.052 13.8 1.3 1.5 9.1 0.0 3.2 3 0 0 3 3 3 0 NUMOD1 domain Lactamase_B_6 PF16661.5 EEA06853.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain OPA3 PF07047.12 EEA06855.1 - 9.4e-21 73.9 0.0 1.3e-20 73.4 0.0 1.3 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Holin_2-3 PF13272.6 EEA06855.1 - 0.037 14.3 0.0 0.089 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative 2/3 transmembrane domain holin Radical_SAM PF04055.21 EEA06856.1 - 2.8e-07 31.1 0.0 4.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EEA06856.1 - 0.00093 19.3 0.0 0.0035 17.4 0.0 2.0 1 0 0 1 1 1 1 4Fe-4S single cluster domain DUF624 PF04854.14 EEA06856.1 - 0.13 12.3 1.4 0.28 11.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF624 AAA PF00004.29 EEA06857.1 - 1e-42 145.7 0.0 4.7e-42 143.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA06857.1 - 2.5e-11 43.2 0.6 5.2e-11 42.2 0.6 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EEA06857.1 - 2.4e-10 40.2 0.0 4.9e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EEA06857.1 - 3.4e-07 30.5 0.0 8.8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA06857.1 - 1.3e-05 25.5 0.2 0.0053 17.0 0.2 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EEA06857.1 - 1.5e-05 24.8 0.0 2.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EEA06857.1 - 2.5e-05 23.6 0.0 4.2e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EEA06857.1 - 5.3e-05 23.7 0.2 0.0009 19.7 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EEA06857.1 - 8.8e-05 22.5 0.1 0.00072 19.6 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EEA06857.1 - 0.0007 20.1 0.0 0.0017 18.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EEA06857.1 - 0.0028 17.4 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EEA06857.1 - 0.004 17.3 0.0 0.01 16.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EEA06857.1 - 0.0054 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EEA06857.1 - 0.0055 16.0 0.2 0.011 14.9 0.0 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_28 PF13521.6 EEA06857.1 - 0.0076 16.5 0.1 0.02 15.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 EEA06857.1 - 0.0093 16.3 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EEA06857.1 - 0.017 14.5 0.1 0.032 13.6 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 EEA06857.1 - 0.019 14.6 0.0 0.068 12.8 0.0 2.0 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain AAA_3 PF07726.11 EEA06857.1 - 0.024 14.5 0.1 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA06857.1 - 0.028 14.2 0.2 0.075 12.7 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EEA06857.1 - 0.034 13.7 0.9 0.47 10.0 0.2 2.4 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 EEA06857.1 - 0.035 13.4 0.1 0.85 8.9 0.1 2.4 1 1 1 2 2 2 0 KaiC PhoH PF02562.16 EEA06857.1 - 0.041 13.3 0.1 0.13 11.7 0.1 1.7 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.12 EEA06857.1 - 0.043 13.7 0.0 0.47 10.4 0.0 2.2 1 1 1 2 2 2 0 NACHT domain ABC_tran PF00005.27 EEA06857.1 - 0.096 13.2 0.1 0.39 11.2 0.1 2.3 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 EEA06857.1 - 0.1 12.3 0.2 0.29 10.8 0.2 1.7 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EEA06857.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EEA06857.1 - 0.11 12.0 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EEA06857.1 - 0.13 12.1 0.3 1.2 9.0 0.1 2.5 2 1 0 2 2 2 0 NTPase Parvo_NS1 PF01057.17 EEA06857.1 - 0.13 11.3 0.0 0.29 10.2 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Yippee-Mis18 PF03226.14 EEA06858.1 - 1.4e-13 50.9 0.3 1.8e-13 50.6 0.3 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Auto_anti-p27 PF06677.12 EEA06858.1 - 0.0042 17.2 1.8 1 9.6 0.1 2.7 3 0 0 3 3 3 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-Mss51 PF13824.6 EEA06858.1 - 0.0063 16.6 0.1 0.49 10.5 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 CpXC PF14353.6 EEA06858.1 - 0.0096 16.0 0.5 1.2 9.2 0.0 2.1 1 1 1 2 2 2 1 CpXC protein zf-C2H2 PF00096.26 EEA06858.1 - 0.014 15.8 1.1 0.42 11.2 0.1 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Kp4 PF09044.10 EEA06858.1 - 0.016 15.3 0.3 1.3 9.1 0.1 2.2 2 0 0 2 2 2 0 Kp4 zf_C2H2_13 PF18508.1 EEA06858.1 - 0.021 14.4 0.2 0.58 9.8 0.0 2.6 2 0 0 2 2 2 0 Zinc finger domain DZR PF12773.7 EEA06858.1 - 0.023 14.7 0.2 4.1 7.5 0.0 2.1 2 0 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.6 EEA06858.1 - 0.039 14.3 0.6 9.3 6.7 0.2 2.2 1 1 1 2 2 2 0 Restriction alleviation protein Lar RIG-I_C-RD PF11648.8 EEA06858.1 - 0.046 14.0 0.2 0.067 13.4 0.2 1.3 1 1 0 1 1 1 0 C-terminal domain of RIG-I zinc_ribbon_6 PF14599.6 EEA06858.1 - 0.046 13.7 2.1 0.054 13.5 0.1 2.0 1 1 0 2 2 2 0 Zinc-ribbon zf-C2H2_3 PF13878.6 EEA06858.1 - 0.068 13.0 0.3 0.39 10.6 0.1 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-ribbon_3 PF13248.6 EEA06858.1 - 0.076 12.5 1.0 7.7 6.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EEA06858.1 - 0.079 12.5 0.9 12 5.5 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf_UBZ PF18439.1 EEA06858.1 - 0.1 12.2 1.5 0.38 10.4 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-B_box PF00643.24 EEA06858.1 - 0.13 12.5 1.1 15 5.9 0.1 2.3 2 0 0 2 2 2 0 B-box zinc finger zf-C2H2_4 PF13894.6 EEA06858.1 - 0.26 12.2 2.0 0.57 11.2 0.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger UFD1 PF03152.14 EEA06860.1 - 3.3e-77 257.8 0.0 4.2e-77 257.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Erythrovirus_X PF06795.11 EEA06860.1 - 0.0019 18.5 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 Erythrovirus X protein CDC48_N PF02359.18 EEA06860.1 - 0.048 13.8 0.0 0.12 12.5 0.0 1.7 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain Fanconi_A PF03511.14 EEA06860.1 - 0.18 11.7 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Fanconi anaemia group A protein SF1-HH PF16275.5 EEA06861.1 - 1.1e-30 106.3 0.2 3.4e-30 104.7 0.2 1.9 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EEA06861.1 - 6.8e-06 25.8 0.0 1.7e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 EEA06861.1 - 0.00039 20.3 0.6 0.46 10.5 0.1 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 EEA06861.1 - 0.0014 18.6 7.9 0.0059 16.6 0.5 2.7 2 0 0 2 2 2 2 Zinc knuckle RRS1 PF04939.12 EEA06862.1 - 6.7e-41 139.8 3.9 1.1e-40 139.2 3.9 1.3 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) KI67R PF08065.12 EEA06862.1 - 1.4 9.5 8.3 0.44 11.1 4.1 2.1 2 1 0 2 2 2 0 KI67R (NUC007) repeat Ribosomal_L28e PF01778.17 EEA06863.1 - 1.4e-25 90.2 3.6 1.6e-25 90.1 3.6 1.0 1 0 0 1 1 1 1 Ribosomal L28e protein family PP1 PF07430.11 EEA06864.1 - 0.04 14.0 0.1 1.8 8.7 0.0 2.7 2 0 0 2 2 2 0 Phloem filament protein PP1 cystatin-like domain tRNA_int_endo PF01974.17 EEA06865.1 - 8.6e-16 57.8 0.1 2e-15 56.6 0.1 1.6 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Myb_DNA-bind_7 PF15963.5 EEA06866.1 - 2.3e-18 65.8 5.2 2.3e-18 65.8 5.2 1.7 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EEA06866.1 - 0.027 14.6 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Rtf2 PF04641.12 EEA06867.1 - 3.3e-45 154.5 0.0 4.2e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Lep_receptor_Ig PF06328.11 EEA06867.1 - 0.0038 17.1 0.5 0.45 10.5 0.1 2.4 2 0 0 2 2 2 2 Ig-like C2-type domain zf-Nse PF11789.8 EEA06867.1 - 0.0067 16.2 0.4 2 8.3 0.0 2.3 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 EEA06867.1 - 0.055 13.6 0.0 0.15 12.2 0.0 1.7 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 EEA06867.1 - 0.14 12.2 1.7 0.45 10.6 0.1 2.2 2 0 0 2 2 2 0 RING-type zinc-finger PT-VENN PF04829.13 EEA06868.1 - 0.42 10.7 5.0 0.82 9.8 5.0 1.4 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif SbmA_BacA PF05992.12 EEA06870.1 - 9.9e-53 179.6 12.9 1.2e-52 179.3 12.9 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 EEA06870.1 - 0.041 13.3 10.0 0.035 13.5 6.5 2.3 2 1 0 2 2 2 0 ABC transporter transmembrane region 2 Pesticin PF16754.5 EEA06870.1 - 0.09 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin homologue of phage lysozyme, C-term SbmA_BacA PF05992.12 EEA06871.1 - 3.2e-61 207.5 5.0 3.8e-61 207.3 5.0 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 EEA06871.1 - 6.4e-07 29.0 2.4 1.1e-06 28.2 0.2 2.2 2 1 0 2 2 2 1 ABC transporter transmembrane region 2 Metallophos PF00149.28 EEA06872.1 - 4.1e-15 56.8 3.5 3.4e-14 53.8 3.5 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Aa_trans PF01490.18 EEA06873.1 - 1.3e-53 182.2 44.9 2.2e-53 181.4 44.9 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein SafA PF17073.5 EEA06873.1 - 0.23 11.5 0.1 0.23 11.5 0.1 2.8 3 1 0 3 3 3 0 Two-component-system connector protein Trp_Tyr_perm PF03222.13 EEA06873.1 - 1.8 7.5 38.5 4.1 6.3 38.5 1.6 1 1 0 1 1 1 0 Tryptophan/tyrosine permease family PMC2NT PF08066.12 EEA06874.1 - 4.9 7.9 6.9 8.7 7.1 0.1 4.5 5 0 0 5 5 5 0 PMC2NT (NUC016) domain DUF4325 PF14213.6 EEA06875.1 - 0.023 14.4 0.5 3.4 7.4 0.0 4.1 5 0 0 5 5 5 0 STAS-like domain of unknown function (DUF4325) DUF543 PF04418.12 EEA06876.1 - 0.0003 20.7 0.1 0.0004 20.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF543) DUF3100 PF11299.8 EEA06876.1 - 0.0093 15.4 0.0 0.01 15.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3100) LSM PF01423.22 EEA06878.1 - 2.1e-18 65.8 0.4 2.7e-18 65.4 0.4 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA06878.1 - 0.0026 17.9 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain PIG-L PF02585.17 EEA06879.1 - 1e-21 77.9 0.0 1.3e-21 77.6 0.0 1.1 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF4234 PF14018.6 EEA06879.1 - 1.8 8.7 6.1 11 6.2 0.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4234) KH_1 PF00013.29 EEA06881.1 - 4.5e-10 39.2 1.5 2.1e-08 33.9 1.7 2.4 2 0 0 2 2 2 1 KH domain BRCT_assoc PF12820.7 EEA06881.1 - 0.033 14.0 1.7 0.073 12.9 1.7 1.6 1 1 0 1 1 1 0 Serine-rich domain associated with BRCT KH_4 PF13083.6 EEA06881.1 - 0.08 12.8 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 KH domain Plasmod_dom_1 PF09715.10 EEA06881.1 - 2.2 8.4 10.4 0.25 11.4 0.4 3.3 3 0 0 3 3 3 0 Plasmodium protein of unknown function (Plasmod_dom_1) RRM_1 PF00076.22 EEA06885.1 - 5.6e-33 112.6 0.1 2.1e-15 56.3 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA06885.1 - 3.3e-06 27.1 0.0 0.001 19.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif BRAP2 PF07576.12 EEA06885.1 - 2.7e-05 24.3 2.2 0.089 13.0 0.0 3.1 3 1 1 4 4 4 2 BRCA1-associated protein 2 RNA_bind PF08675.11 EEA06885.1 - 6.8e-05 22.8 0.1 0.81 9.8 0.0 3.7 3 0 0 3 3 3 2 RNA binding domain Band_3_cyto PF07565.13 EEA06888.1 - 3.1 7.5 8.2 3.4 7.4 8.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Metallophos PF00149.28 EEA06890.1 - 3.1e-36 125.8 0.7 4.8e-36 125.2 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EEA06890.1 - 0.052 13.2 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain STPPase_N PF16891.5 EEA06890.1 - 0.056 13.9 0.1 0.14 12.7 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain zf-HYPF PF07503.12 EEA06890.1 - 0.11 12.3 1.2 1.2 9.0 0.1 2.5 2 0 0 2 2 2 0 HypF finger Helicase_C_2 PF13307.6 EEA06891.1 - 4.2e-42 144.2 0.0 8.8e-42 143.2 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EEA06891.1 - 1.6e-32 112.5 10.5 1.3e-22 80.3 3.1 4.7 3 1 0 3 3 3 2 DEAD_2 HBB PF06777.11 EEA06891.1 - 4.8e-28 98.1 0.8 5.5e-22 78.4 0.1 2.6 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 EEA06891.1 - 1.5e-08 34.8 0.7 4e-06 26.9 0.1 3.1 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EEA06891.1 - 0.1 11.3 0.0 1.2 7.8 0.0 2.2 1 1 0 1 1 1 0 SNF2 family N-terminal domain TGT PF01702.18 EEA06892.1 - 2.1e-139 464.5 0.0 2.7e-139 464.2 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF2764 PF10962.8 EEA06892.1 - 0.043 13.3 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) Patched PF02460.18 EEA06894.1 - 2.6e-95 320.2 24.7 3.3e-64 217.4 10.0 3.2 3 0 0 3 3 3 3 Patched family Sterol-sensing PF12349.8 EEA06894.1 - 2.8e-29 102.0 2.8 2.8e-29 102.0 2.8 2.7 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 EEA06894.1 - 0.12 10.0 10.4 0.22 9.1 10.4 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family MRP-S26 PF14943.6 EEA06896.1 - 0.0016 18.4 2.3 0.0023 17.9 2.3 1.3 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 FAM25 PF15825.5 EEA06896.1 - 0.02 15.2 0.2 0.64 10.4 0.0 2.3 2 0 0 2 2 2 0 FAM25 family RTP1_C1 PF10363.9 EEA06896.1 - 0.025 14.8 0.8 0.044 14.0 0.2 1.7 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 eIF2A PF08662.11 EEA06897.1 - 1.4e-51 175.1 0.1 3.3e-48 164.2 0.1 3.0 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EEA06897.1 - 0.0035 18.1 0.2 12 7.0 0.0 4.8 4 1 1 5 5 5 1 WD domain, G-beta repeat Atx10homo_assoc PF09759.9 EEA06899.1 - 0.5 10.4 6.0 0.092 12.8 0.7 2.3 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain YcaO_C PF18381.1 EEA06900.1 - 0.11 12.5 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 YcaO cyclodehydratase C-terminal domain PGK PF00162.19 EEA06901.1 - 4.6e-144 480.0 0.5 5.2e-144 479.9 0.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase NARP1 PF12569.8 EEA06902.1 - 5e-55 187.4 32.0 2e-46 159.0 21.6 4.0 3 1 0 3 3 3 3 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 EEA06902.1 - 6.3e-09 36.2 9.9 0.17 12.4 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EEA06902.1 - 1.6e-07 30.9 20.1 0.00024 21.0 0.0 8.8 10 1 0 10 10 10 1 Tetratricopeptide repeat TPR_1 PF00515.28 EEA06902.1 - 1.6e-06 27.6 16.9 0.008 16.0 0.2 6.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA06902.1 - 9e-06 25.7 12.8 0.017 15.5 0.1 6.1 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA06902.1 - 3.1e-05 24.4 0.0 5 8.2 0.0 5.8 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06902.1 - 0.0011 18.5 2.8 0.31 10.8 0.0 4.8 4 1 1 5 5 5 1 TPR repeat ANAPC3 PF12895.7 EEA06902.1 - 0.0014 18.8 14.3 0.02 15.1 2.4 5.3 4 2 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EEA06902.1 - 0.0017 18.3 1.3 37 4.7 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06902.1 - 0.0089 16.3 1.1 5.7 7.3 0.0 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA06902.1 - 0.038 14.7 0.1 2.4e+02 2.5 0.1 4.8 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EEA06902.1 - 0.28 11.9 7.1 63 4.5 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA06902.1 - 0.32 11.3 25.6 1.6 9.1 0.1 7.9 9 0 0 9 9 7 0 Tetratricopeptide repeat YgaB PF14182.6 EEA06902.1 - 0.47 10.9 5.9 4.7 7.7 0.5 3.2 2 0 0 2 2 2 0 YgaB-like protein Seipin PF06775.14 EEA06903.1 - 1.5e-64 217.7 7.9 2.2e-64 217.2 7.9 1.3 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) RRM_1 PF00076.22 EEA06904.1 - 6.9e-18 64.2 0.0 1.1e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA06904.1 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EEA06904.1 - 0.03 14.2 0.0 0.063 13.1 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif SecY PF00344.20 EEA06905.1 - 1.2e-70 238.3 18.2 1.4e-70 238.0 18.2 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EEA06905.1 - 1.4e-17 63.2 2.2 2.1e-17 62.6 0.1 2.4 2 0 0 2 2 2 1 Plug domain of Sec61p NRBF2 PF08961.10 EEA06906.1 - 0.012 15.2 1.3 0.012 15.2 1.3 2.9 3 1 1 4 4 4 0 Nuclear receptor-binding factor 2, autophagy regulator CC2-LZ PF16516.5 EEA06906.1 - 0.21 12.0 8.2 0.25 11.7 0.4 3.1 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PHM7_cyt PF14703.6 EEA06906.1 - 0.25 11.6 7.2 0.1 12.8 3.8 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CENP-H PF05837.12 EEA06906.1 - 4.6 7.7 14.2 0.71 10.3 1.0 3.4 3 0 0 3 3 3 0 Centromere protein H (CENP-H) TPR_14 PF13428.6 EEA06907.1 - 0.016 16.0 0.3 14 6.8 0.0 4.9 6 1 1 7 7 7 0 Tetratricopeptide repeat RhoGAP-FF1 PF16512.5 EEA06907.1 - 0.025 15.3 6.6 16 6.3 0.1 4.7 4 0 0 4 4 4 0 p190-A and -B Rho GAPs FF domain TPR_12 PF13424.6 EEA06907.1 - 0.13 12.6 2.3 2.3 8.6 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EEA06907.1 - 4.9 7.2 5.8 21 5.1 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Ank_2 PF12796.7 EEA06908.1 - 2.1e-17 63.5 0.9 3.2e-11 43.7 0.1 4.3 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 EEA06908.1 - 8.9e-17 60.7 1.3 0.00051 20.4 0.1 6.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EEA06908.1 - 6.9e-13 47.5 3.4 0.0063 16.9 0.0 7.2 7 0 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EEA06908.1 - 2.7e-11 43.8 1.9 0.0031 18.1 0.1 6.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA06908.1 - 4.2e-09 36.5 0.4 0.086 13.2 0.0 4.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Plasmod_dom_1 PF09715.10 EEA06908.1 - 0.061 13.4 0.0 0.24 11.5 0.0 2.1 1 0 0 1 1 1 0 Plasmodium protein of unknown function (Plasmod_dom_1) zinc_ribbon_2 PF13240.6 EEA06908.1 - 0.11 12.3 6.1 0.37 10.6 6.1 2.0 1 0 0 1 1 1 0 zinc-ribbon domain 2OG-FeII_Oxy_2 PF13532.6 EEA06910.1 - 1.4e-15 58.0 0.0 2.8e-15 57.1 0.1 1.4 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF3638 PF12340.8 EEA06911.1 - 3.7e-22 78.8 1.0 1e-19 70.8 0.3 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EEA06911.1 - 7.8e-14 50.8 0.1 1.7e-13 49.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) EF-hand_6 PF13405.6 EEA06911.1 - 1e-07 31.3 0.2 0.018 14.9 0.0 3.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EEA06911.1 - 4.1e-05 22.8 0.6 0.081 12.5 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EEA06911.1 - 0.0021 18.5 0.3 1.1 9.7 0.0 3.5 2 0 0 2 2 2 1 EF-hand domain pair Vps62 PF06101.11 EEA06911.1 - 0.0051 15.2 0.0 0.0085 14.4 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Trypan_PARP PF05887.11 EEA06911.1 - 3.9 7.4 3.9 8 6.4 3.9 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TerY_C PF15616.6 EEA06912.1 - 0.00024 21.2 0.5 0.00076 19.6 0.5 1.8 1 0 0 1 1 1 1 TerY-C metal binding domain CpXC PF14353.6 EEA06912.1 - 0.017 15.1 0.1 0.34 11.0 0.0 2.5 2 0 0 2 2 2 0 CpXC protein zf-Di19 PF05605.12 EEA06912.1 - 0.025 14.8 1.5 2.8 8.3 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1595 PF12760.7 EEA06912.1 - 0.15 12.1 2.5 4.1 7.5 0.2 2.4 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-XS PF03470.14 EEA06912.1 - 3 8.2 9.6 6.5 7.1 1.3 2.7 2 0 0 2 2 2 0 XS zinc finger domain ATP-grasp_2 PF08442.10 EEA06913.1 - 2.9e-55 187.0 3.2 7.1e-48 162.8 0.2 2.4 1 1 0 2 2 2 2 ATP-grasp domain Ligase_CoA PF00549.19 EEA06913.1 - 1.3e-19 70.5 1.6 2.5e-19 69.6 1.6 1.5 1 0 0 1 1 1 1 CoA-ligase Toprim_2 PF13155.6 EEA06913.1 - 0.002 18.5 0.1 0.13 12.7 0.0 2.5 2 0 0 2 2 2 1 Toprim-like Succ_CoA_lig PF13607.6 EEA06913.1 - 0.0047 16.7 0.1 0.013 15.2 0.1 1.7 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain G10 PF01125.17 EEA06914.1 - 8.9e-57 191.0 5.7 9.7e-57 190.8 5.7 1.0 1 0 0 1 1 1 1 G10 protein DUF5454 PF17535.2 EEA06914.1 - 0.019 14.4 0.1 0.022 14.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5454) DUF1810 PF08837.11 EEA06914.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1810) RNase_T PF00929.24 EEA06915.1 - 4.8e-08 33.7 0.0 1e-07 32.7 0.0 1.6 1 1 0 1 1 1 1 Exonuclease His_Phos_1 PF00300.22 EEA06915.1 - 0.0062 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) S4 PF01479.25 EEA06916.1 - 1.2e-07 31.3 0.0 3.4e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EEA06916.1 - 6.5e-07 30.2 1.7 8.9e-07 29.7 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain zf-SNAP50_C PF12251.8 EEA06917.1 - 6.3e-44 150.1 5.1 6.3e-44 150.1 5.1 1.8 2 0 0 2 2 2 1 snRNA-activating protein of 50kDa MW C terminal Qua1 PF16274.5 EEA06917.1 - 0.22 11.4 2.8 0.48 10.3 0.3 2.5 2 0 0 2 2 2 0 Qua1 domain NicO PF03824.16 EEA06918.1 - 0.019 14.3 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein LSM PF01423.22 EEA06919.1 - 4.6e-14 51.9 2.2 7.3e-14 51.2 2.2 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EEA06919.1 - 0.0031 17.1 0.3 0.0052 16.4 0.3 1.4 1 0 0 1 1 1 1 Hfq protein DUF1461 PF07314.11 EEA06919.1 - 0.0047 16.9 1.8 0.0052 16.7 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1461) JAB PF01398.21 EEA06920.1 - 8.5e-15 54.8 0.2 2.5e-14 53.3 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EEA06920.1 - 7.5e-08 32.8 0.1 1.2e-07 32.1 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function CCDC158 PF15921.5 EEA06920.1 - 0.15 9.9 0.3 0.22 9.3 0.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Flavodoxin_2 PF02525.17 EEA06921.1 - 4.4e-32 111.4 0.0 4.9e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EEA06921.1 - 7.8e-06 25.7 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase RRP7 PF12923.7 EEA06922.1 - 0.01 16.0 0.2 0.031 14.4 0.2 1.8 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain IQ PF00612.27 EEA06923.1 - 0.00036 20.1 0.5 0.0045 16.7 0.1 2.4 2 0 0 2 2 2 1 IQ calmodulin-binding motif Xpo1 PF08389.12 EEA06923.1 - 0.19 11.8 4.1 0.18 11.9 0.2 2.7 3 0 0 3 3 3 0 Exportin 1-like protein cwf21 PF08312.12 EEA06924.1 - 1.5e-09 37.9 2.8 1.5e-09 37.9 2.8 1.9 2 0 0 2 2 2 1 cwf21 domain TSA PF03249.13 EEA06924.1 - 0.061 12.1 0.2 0.088 11.6 0.2 1.1 1 0 0 1 1 1 0 Type specific antigen zf-CCCH PF00642.24 EEA06925.1 - 1.1e-14 53.9 11.9 1.3e-06 28.2 1.6 3.3 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EEA06925.1 - 1.4e-06 28.0 14.1 0.001 18.8 0.2 3.4 3 0 0 3 3 3 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EEA06925.1 - 0.00082 19.3 16.6 0.0058 16.7 2.4 4.0 3 1 0 3 3 3 2 Zinc finger domain Torus PF16131.5 EEA06925.1 - 0.0018 18.9 12.5 0.012 16.3 1.0 3.5 1 1 2 3 3 3 2 Torus domain zf-CCCH_3 PF15663.5 EEA06925.1 - 0.0032 17.6 2.9 0.0032 17.6 2.9 2.6 1 1 1 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EEA06925.1 - 0.013 15.9 8.0 0.81 10.3 0.5 3.4 3 1 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Bromodomain PF00439.25 EEA06926.1 - 3.3e-24 84.8 0.3 1.9e-23 82.3 0.3 2.4 1 0 0 1 1 1 1 Bromodomain zf-H3C2 PF16721.5 EEA06926.1 - 0.24 11.8 0.8 0.62 10.5 0.0 2.0 2 0 0 2 2 2 0 Zinc-finger like, probable DNA-binding TMF_TATA_bd PF12325.8 EEA06927.1 - 0.0021 18.2 17.7 0.0021 18.2 17.7 10.6 4 2 7 12 12 12 4 TATA element modulatory factor 1 TATA binding Leu_zip PF15294.6 EEA06927.1 - 0.0058 16.2 5.9 0.0058 16.2 5.9 7.5 2 1 6 9 9 9 2 Leucine zipper Metal_resist PF13801.6 EEA06927.1 - 0.66 10.2 2.8 2.1 8.5 2.8 1.9 1 0 0 1 1 1 0 Heavy-metal resistance FPL PF09758.9 EEA06928.1 - 5.7e-52 175.7 6.6 5.7e-52 175.7 6.6 4.2 6 0 0 6 6 6 1 Uncharacterised conserved protein Pox_A3L PF05288.11 EEA06928.1 - 0.027 14.4 0.1 0.58 10.2 0.0 3.1 2 0 0 2 2 2 0 Poxvirus A3L Protein Helicase_C PF00271.31 EEA06929.1 - 1.7e-14 54.1 0.5 1.7e-14 54.1 0.5 3.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HA2 PF04408.23 EEA06929.1 - 6.5e-09 36.0 1.0 1.5e-08 34.8 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.29 EEA06929.1 - 4.7e-06 26.5 0.1 1.1e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA06929.1 - 0.026 14.8 1.5 0.17 12.1 1.5 2.3 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EEA06929.1 - 0.054 13.5 0.1 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 EEA06929.1 - 0.069 13.1 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 EEA06929.1 - 0.56 10.7 2.2 0.76 10.3 0.0 2.4 3 0 0 3 3 3 0 ABC transporter zf-RanBP PF00641.18 EEA06930.1 - 2.5e-05 23.5 4.6 2.5e-05 23.5 4.6 2.3 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-C3HC4_3 PF13920.6 EEA06930.1 - 0.0016 18.2 7.4 0.0016 18.2 7.4 5.9 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA06930.1 - 0.0021 18.3 9.0 0.0021 18.3 9.0 5.8 7 0 0 7 7 7 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA06930.1 - 0.0032 17.3 8.9 0.0032 17.3 8.9 4.7 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) FOXP-CC PF16159.5 EEA06930.1 - 0.025 15.2 2.9 6.8 7.4 0.4 3.7 1 1 2 3 3 3 0 FOXP coiled-coil domain Cir_N PF10197.9 EEA06931.1 - 6.6e-11 42.2 8.4 2.1e-10 40.6 8.4 1.9 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR Slu7 PF11708.8 EEA06931.1 - 0.0091 15.8 3.2 0.015 15.0 3.2 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor DUF2407_C PF13373.6 EEA06931.1 - 0.79 9.9 3.4 4.3 7.5 1.0 2.2 1 1 1 2 2 2 0 DUF2407 C-terminal domain TPX2 PF06886.11 EEA06931.1 - 1.9 8.8 9.2 4.6 7.6 9.2 1.5 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Pkinase PF00069.25 EEA06932.1 - 6e-31 107.8 2.8 6e-31 107.8 2.8 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06932.1 - 2.4e-11 43.4 0.9 6.1e-11 42.1 0.8 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA06932.1 - 0.062 12.6 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-NPL4 PF05020.15 EEA06932.1 - 0.18 12.0 3.3 9.5 6.4 0.4 2.6 2 0 0 2 2 2 0 NPL4 family, putative zinc binding region Biotin_lipoyl PF00364.22 EEA06934.1 - 3.4e-12 46.0 1.8 5.7e-12 45.3 1.8 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EEA06934.1 - 3.7e-05 23.4 0.2 0.13 12.1 0.0 2.3 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_D23 PF16576.5 EEA06934.1 - 0.0019 17.4 0.1 0.15 11.3 0.0 2.2 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion SNURF PF07192.11 EEA06935.1 - 0.037 13.9 0.0 0.081 12.8 0.0 1.6 2 0 0 2 2 2 0 SNURF/RPN4 protein Raco_middle PF17651.1 EEA06935.1 - 0.17 11.5 2.2 0.098 12.3 0.3 1.5 2 0 0 2 2 2 0 RACo middle region Peptidase_S13 PF02113.15 EEA06937.1 - 0.05 12.3 0.0 0.084 11.6 0.0 1.2 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family Imm51 PF15595.6 EEA06937.1 - 0.058 13.3 0.0 0.22 11.5 0.0 1.9 1 0 0 1 1 1 0 Immunity protein 51 YtfJ_HI0045 PF09695.10 EEA06939.1 - 0.012 15.2 0.1 1.5 8.5 0.0 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (YtfJ_HI0045) Pkinase PF00069.25 EEA06940.1 - 1.1e-66 224.9 0.1 2.2e-66 223.9 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06940.1 - 1.4e-37 129.4 0.0 2.2e-37 128.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EEA06940.1 - 9.5e-28 93.7 11.9 7.3e-05 22.0 0.5 5.7 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 EEA06940.1 - 1.2e-26 92.9 5.6 2.6e-08 34.2 1.2 4.9 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 EEA06940.1 - 9.4e-23 79.8 11.0 0.0002 21.2 0.5 5.5 5 0 0 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 EEA06940.1 - 1e-21 74.9 12.6 0.00023 20.8 0.2 5.8 5 0 0 5 5 5 5 EF-hand domain EF-hand_5 PF13202.6 EEA06940.1 - 1.3e-21 75.1 16.2 3.9e-05 22.9 0.4 5.8 6 0 0 6 6 6 5 EF hand Kdo PF06293.14 EEA06940.1 - 5.2e-08 32.5 0.5 1.2e-06 28.0 0.1 2.8 2 2 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.9 EEA06940.1 - 3.1e-06 27.5 4.0 0.45 10.9 0.0 4.4 3 1 1 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region Kinase-like PF14531.6 EEA06940.1 - 5e-06 26.0 0.1 7.3e-05 22.2 0.1 2.6 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EEA06940.1 - 0.0053 15.6 1.6 0.0059 15.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EEA06940.1 - 0.0073 16.2 0.0 0.063 13.2 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EEA06940.1 - 0.023 14.2 0.0 0.056 12.9 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL EF-hand_4 PF12763.7 EEA06940.1 - 0.031 14.2 3.1 2 8.4 0.0 3.6 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand TMEM117 PF15113.6 EEA06940.1 - 0.035 13.0 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 TMEM117 protein family SpoOE-like PF09388.10 EEA06941.1 - 0.13 12.2 1.4 0.38 10.7 0.1 2.5 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein SR-25 PF10500.9 EEA06942.1 - 1.8 8.1 11.7 2.6 7.6 11.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glycos_transf_2 PF00535.26 EEA06945.1 - 6.3e-18 65.2 0.1 3.1e-17 62.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 EEA06945.1 - 3e-05 24.3 0.0 0.00013 22.2 0.0 2.1 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 EEA06945.1 - 0.0033 17.4 0.0 0.0049 16.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EEA06945.1 - 0.0092 15.5 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 EEA06945.1 - 0.047 13.4 0.4 0.16 11.7 0.1 2.0 2 0 0 2 2 2 0 N-terminal domain of galactosyltransferase Baculo_11_kDa PF06143.11 EEA06945.1 - 0.14 11.7 0.3 0.29 10.7 0.3 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Pkinase PF00069.25 EEA06946.1 - 4.5e-36 124.6 1.3 8.4e-35 120.4 0.3 3.1 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06946.1 - 7.6e-08 32.0 0.1 1.4e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA06946.1 - 0.00016 21.7 0.1 0.00025 21.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EEA06947.1 - 1.8e-49 168.5 0.1 2.4e-48 164.8 0.0 2.6 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA06947.1 - 3.9e-31 108.3 0.0 3.1e-30 105.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ccdc124 PF06244.12 EEA06948.1 - 0.12 13.0 0.0 25 5.4 0.0 2.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 124 /Oxs1 Baculo_PEP_C PF04513.12 EEA06949.1 - 0.023 14.8 1.2 0.048 13.7 1.2 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 EEA06949.1 - 0.04 14.2 0.1 0.04 14.2 0.1 2.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Ste5 PF11610.8 EEA06949.1 - 0.14 12.0 0.2 4.4 7.2 0.1 2.4 2 0 0 2 2 2 0 Scaffold protein Ste5, Fus3-binding region CRAL_TRIO_2 PF13716.6 EEA06950.1 - 2.4e-09 37.5 1.0 6e-09 36.2 0.1 2.3 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EEA06950.1 - 2.6e-06 27.2 0.3 2.6e-06 27.2 0.3 2.0 2 0 0 2 2 2 1 CRAL/TRIO domain BLOC1_2 PF10046.9 EEA06950.1 - 0.75 10.1 3.9 2.9 8.3 0.2 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SbmA_BacA PF05992.12 EEA06952.1 - 3.7e-39 135.0 11.4 4.2e-39 134.8 11.4 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family Pep1_7 PF17232.2 EEA06952.1 - 0.17 12.4 0.5 0.61 10.6 0.5 2.0 1 1 0 1 1 1 0 Elicitor peptide 1-7 SbmA_BacA PF05992.12 EEA06953.1 - 2.2e-58 198.2 13.9 2.5e-58 198.0 13.9 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.15 EEA06953.1 - 0.00044 19.7 15.4 0.0093 15.4 15.4 2.5 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 ThrE PF06738.12 EEA06953.1 - 2.9 7.2 6.3 1.2 8.4 3.4 1.9 2 1 0 2 2 2 0 Putative threonine/serine exporter DUF3523 PF12037.8 EEA06955.1 - 3.5e-71 239.7 25.7 5e-71 239.2 25.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 EEA06955.1 - 3.3e-21 76.1 0.0 6.8e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA06955.1 - 0.00019 21.2 0.0 0.00043 20.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA06955.1 - 0.0015 18.9 1.3 0.25 11.7 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EEA06955.1 - 0.01 16.1 3.4 0.22 11.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_lid_3 PF17862.1 EEA06955.1 - 0.01 15.6 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA+ lid domain Mg_chelatase PF01078.21 EEA06955.1 - 0.027 13.8 0.1 0.17 11.2 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA06955.1 - 0.028 14.6 0.4 0.11 12.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA06955.1 - 0.033 14.7 0.0 0.033 14.7 0.0 3.1 3 1 0 3 3 3 0 AAA domain AAA_5 PF07728.14 EEA06955.1 - 0.035 14.1 0.1 0.15 12.0 0.1 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EEA06955.1 - 0.089 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EEA06955.1 - 0.14 11.9 0.0 0.14 11.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EEA06955.1 - 0.28 11.2 2.6 1 9.3 0.0 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cgr1 PF03879.14 EEA06956.1 - 2.1e-05 24.8 19.0 2.6e-05 24.6 19.0 1.1 1 0 0 1 1 1 1 Cgr1 family PhoD PF09423.10 EEA06957.1 - 2.2e-17 63.1 0.0 1.7e-15 57.0 0.0 2.1 1 1 1 2 2 2 2 PhoD-like phosphatase TPR_1 PF00515.28 EEA06958.1 - 4e-20 70.7 0.1 0.00083 19.1 0.0 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EEA06958.1 - 8.8e-20 69.2 0.5 0.017 15.2 0.0 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EEA06958.1 - 1.7e-16 59.3 1.7 0.004 17.4 0.0 6.0 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EEA06958.1 - 1.3e-15 57.6 0.3 5.2e-05 23.7 0.0 5.7 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EEA06958.1 - 3.9e-15 55.2 2.1 1.3e-06 28.0 0.6 5.1 3 2 2 5 5 5 4 TPR repeat TPR_7 PF13176.6 EEA06958.1 - 1e-11 44.0 0.2 0.19 11.8 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EEA06958.1 - 1.1e-11 44.8 3.2 0.0036 17.6 0.0 5.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EEA06958.1 - 9e-11 41.1 2.9 0.33 11.3 0.0 6.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA06958.1 - 2.3e-10 40.4 0.0 0.083 13.7 0.0 6.4 3 2 4 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA06958.1 - 1.2e-09 38.2 8.8 0.02 15.1 0.4 5.4 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EEA06958.1 - 1.1e-08 35.1 0.0 0.0019 18.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 EEA06958.1 - 1.5e-07 31.0 0.5 5.8e-05 22.4 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EEA06958.1 - 7.1e-07 29.5 0.0 0.13 13.0 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC8 PF04049.13 EEA06958.1 - 1.4e-05 25.1 0.0 3.6e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_16 PF13432.6 EEA06958.1 - 2.8e-05 24.7 0.0 0.58 10.9 0.0 4.6 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EEA06958.1 - 0.047 13.6 0.7 9.8 6.2 0.0 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TcdB_N PF12918.7 EEA06958.1 - 0.96 9.8 4.0 2.9 8.2 0.3 3.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain TFIIB PF00382.19 EEA06959.1 - 0.0046 17.0 0.1 0.31 11.1 0.0 2.8 2 0 0 2 2 2 1 Transcription factor TFIIB repeat TetR_N PF00440.23 EEA06959.1 - 0.026 14.3 0.1 0.07 12.9 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_7 PF02796.15 EEA06959.1 - 0.046 13.8 4.8 0.06 13.4 0.1 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 EEA06959.1 - 0.65 9.8 4.9 0.2 11.5 0.4 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain Ribosomal_S27e PF01667.17 EEA06960.1 - 7.3e-26 89.6 6.2 9.2e-26 89.3 6.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 Prok-RING_1 PF14446.6 EEA06960.1 - 0.19 11.7 3.9 0.3 11.0 3.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 dCMP_cyt_deam_1 PF00383.23 EEA06961.1 - 8e-09 35.3 0.0 1.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA06961.1 - 1e-06 28.5 0.0 0.0039 16.9 0.1 2.2 2 0 0 2 2 2 2 MafB19-like deaminase CBS PF00571.28 EEA06962.1 - 0.0032 17.9 1.2 0.017 15.6 0.1 2.6 3 0 0 3 3 3 1 CBS domain THF_DHG_CYH_C PF02882.19 EEA06962.1 - 0.086 12.1 1.2 0.24 10.7 0.2 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain tRNA-synt_1b PF00579.25 EEA06963.1 - 1.6e-17 63.8 0.0 1.5e-16 60.6 0.0 2.4 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) Iso_dh PF00180.20 EEA06964.1 - 3.8e-69 233.5 0.0 4.4e-69 233.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase His_Phos_2 PF00328.22 EEA06965.1 - 3.1e-55 188.1 0.2 3.6e-54 184.6 0.2 2.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EEA06965.1 - 2.3e-29 101.4 2.3 3e-29 101.0 0.5 2.3 2 0 0 2 2 2 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EEA06965.1 - 0.00035 20.2 0.0 0.001 18.7 0.0 1.7 1 0 0 1 1 1 1 RimK-like ATP-grasp domain FKBP_C PF00254.28 EEA06967.1 - 8.4e-07 29.2 0.1 1.5e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 EEA06967.1 - 0.016 15.0 0.1 0.034 14.0 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA06967.1 - 0.021 14.9 0.1 0.045 13.9 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat MIT PF04212.18 EEA06967.1 - 0.042 13.9 0.1 0.07 13.2 0.1 1.3 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 EEA06967.1 - 0.11 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 TPR repeat NOB1_Zn_bind PF08772.11 EEA06968.1 - 1e-21 76.9 0.2 2e-21 75.9 0.2 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EEA06968.1 - 4.7e-18 65.5 0.0 8.5e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 PIN domain of ribonuclease tRNA-synt_2 PF00152.20 EEA06969.1 - 2e-72 243.9 0.0 2.6e-72 243.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EEA06969.1 - 0.0012 18.4 0.1 0.81 9.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 EEA06969.1 - 0.0023 17.9 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2012 PF09430.10 EEA06969.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) DHHC PF01529.20 EEA06971.1 - 4.3e-33 114.3 16.2 4.3e-33 114.3 16.2 2.4 2 1 0 2 2 2 2 DHHC palmitoyltransferase Ge1_WD40 PF16529.5 EEA06972.1 - 0.025 13.5 0.1 0.03 13.3 0.1 1.1 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactamase_B_4 PF13691.6 EEA06973.1 - 1.6e-08 34.1 0.0 4.4e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EEA06973.1 - 3.7e-08 33.1 0.0 0.00024 20.7 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EEA06973.1 - 0.0011 19.0 0.0 0.0062 16.6 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily WSD PF15613.6 EEA06974.1 - 0.011 16.2 0.0 0.036 14.5 0.0 1.9 1 0 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Arfaptin PF06456.13 EEA06974.1 - 0.062 12.9 0.4 7.6 6.0 0.2 2.5 1 1 1 2 2 2 0 Arfaptin-like domain UDG PF03167.19 EEA06975.1 - 8.9e-20 71.2 0.0 1.2e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily adh_short PF00106.25 EEA06976.1 - 3.1e-34 118.2 0.1 3.8e-34 117.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA06976.1 - 7e-18 65.0 0.1 1.2e-17 64.3 0.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA06976.1 - 1.2e-12 48.1 0.1 1.7e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Ribosomal_L10 PF00466.20 EEA06977.1 - 1.6e-13 50.6 0.1 3e-13 49.7 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EEA06977.1 - 3e-10 39.9 0.0 5.3e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Nic96 PF04097.14 EEA06978.1 - 0.00018 20.2 0.8 0.022 13.2 0.1 2.5 2 1 0 2 2 2 2 Nup93/Nic96 CorA PF01544.18 EEA06978.1 - 0.008 15.5 0.4 0.008 15.5 0.4 2.0 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein RRM_1 PF00076.22 EEA06979.1 - 3.5e-16 58.8 0.0 5.1e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA06979.1 - 0.0041 17.2 0.2 0.075 13.2 0.0 2.4 1 1 1 2 2 2 1 RNA recognition motif DUF2102 PF09875.9 EEA06979.1 - 0.065 13.0 0.0 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2102) PHM7_cyt PF14703.6 EEA06979.1 - 0.067 13.4 0.7 2.6 8.2 0.0 2.6 1 1 2 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RL PF17797.1 EEA06979.1 - 0.071 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 RL domain RRM_5 PF13893.6 EEA06979.1 - 0.074 12.6 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EEA06979.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EEA06979.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain PhoLip_ATPase_C PF16212.5 EEA06980.1 - 2.2e-53 181.6 20.8 2.2e-53 181.6 20.8 2.6 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA06980.1 - 4.2e-15 55.2 0.8 4.2e-15 55.2 0.8 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EEA06980.1 - 7e-11 42.0 0.1 7e-11 42.0 0.1 3.5 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EEA06980.1 - 3.7e-07 30.7 0.3 0.0023 18.3 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA06980.1 - 1.5e-05 25.0 0.0 5.8e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) SRP54 PF00448.22 EEA06981.1 - 2.7e-74 249.1 0.0 5.9e-74 247.9 0.0 1.6 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EEA06981.1 - 3.1e-31 107.9 0.5 3.1e-31 107.9 0.5 2.6 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 EEA06981.1 - 6.7e-19 67.9 3.0 1.5e-18 66.8 3.0 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EEA06981.1 - 2e-05 24.2 0.4 0.00017 21.2 0.1 2.5 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EEA06981.1 - 8.2e-05 23.1 0.0 0.00043 20.7 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EEA06981.1 - 0.00023 21.3 0.2 0.0011 19.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA06981.1 - 0.00051 20.3 0.5 0.0046 17.2 0.1 2.7 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA06981.1 - 0.0014 18.6 0.1 0.0044 17.0 0.1 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CbiA PF01656.23 EEA06981.1 - 0.0016 18.5 0.0 0.0058 16.7 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EEA06981.1 - 0.0026 17.5 0.0 0.0079 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2209 PF09974.9 EEA06981.1 - 0.0028 18.0 1.2 0.076 13.4 0.2 2.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2209) Zeta_toxin PF06414.12 EEA06981.1 - 0.016 14.5 0.0 0.046 13.0 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EEA06981.1 - 0.023 14.6 0.5 1.9 8.3 0.5 2.6 1 1 0 1 1 1 0 NTPase APS_kinase PF01583.20 EEA06981.1 - 0.023 14.6 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_17 PF13207.6 EEA06981.1 - 0.028 14.8 0.9 0.091 13.2 0.1 2.3 2 1 0 2 2 2 0 AAA domain 6PF2K PF01591.18 EEA06981.1 - 0.033 13.5 0.0 0.079 12.2 0.0 1.7 1 0 0 1 1 1 0 6-phosphofructo-2-kinase ATP_bind_1 PF03029.17 EEA06981.1 - 0.045 13.5 0.2 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.14 EEA06981.1 - 0.087 12.7 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.6 EEA06981.1 - 0.092 13.1 0.0 0.28 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EEA06981.1 - 0.13 12.4 0.1 0.66 10.1 0.1 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EEA06981.1 - 0.2 12.2 0.3 1 9.9 0.3 2.2 1 1 0 1 1 1 0 AAA domain DDE_Tnp_1_3 PF13612.6 EEA06981.1 - 0.32 11.0 3.0 0.16 11.9 0.3 1.9 2 0 0 2 2 1 0 Transposase DDE domain SRPRB PF09439.10 EEA06981.1 - 0.68 9.3 6.7 5.3 6.4 0.1 3.0 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit AAA_31 PF13614.6 EEA06981.1 - 1.5 8.7 5.0 2.8 7.8 0.0 2.8 2 1 0 3 3 3 0 AAA domain ER_lumen_recept PF00810.18 EEA06982.1 - 2.7e-16 60.7 5.2 7.7e-16 59.2 5.2 1.8 1 1 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EEA06982.1 - 2.2 8.1 7.2 0.4 10.5 0.2 3.5 4 1 0 4 4 4 0 PQ loop repeat STOP PF05217.12 EEA06983.1 - 0.0036 17.6 1.8 0.0036 17.6 1.8 3.9 4 0 0 4 4 4 1 STOP protein IBN_N PF03810.19 EEA06984.1 - 2.6e-07 30.5 0.6 9.6e-07 28.6 0.2 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ras PF00071.22 EEA06985.1 - 4.9e-56 188.8 0.0 5.8e-56 188.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA06985.1 - 7.6e-32 110.0 0.0 1.1e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA06985.1 - 1.7e-12 47.1 0.0 2.1e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA06985.1 - 1.1e-06 28.7 0.0 1.6e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA06985.1 - 4.5e-05 22.9 0.1 7.6e-05 22.2 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA06985.1 - 6.5e-05 22.6 0.0 0.0015 18.1 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA06985.1 - 9.8e-05 22.3 0.0 0.003 17.5 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EEA06985.1 - 0.00036 20.3 0.1 0.013 15.3 0.2 2.3 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EEA06985.1 - 0.0034 17.0 0.0 0.0092 15.6 0.0 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EEA06985.1 - 0.0036 17.7 0.0 0.0066 16.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain Septin PF00735.18 EEA06985.1 - 0.0069 15.7 0.1 0.055 12.7 0.1 2.0 2 0 0 2 2 2 1 Septin AAA_24 PF13479.6 EEA06985.1 - 0.021 14.5 0.1 0.043 13.5 0.1 1.5 2 0 0 2 2 1 0 AAA domain ATP_bind_1 PF03029.17 EEA06985.1 - 0.022 14.5 0.1 0.72 9.6 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EEA06985.1 - 0.023 14.1 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EEA06985.1 - 0.024 14.9 0.0 0.047 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EEA06985.1 - 0.031 13.8 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EEA06985.1 - 0.066 13.1 0.3 0.13 12.1 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 EEA06985.1 - 0.085 12.3 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_18 PF13238.6 EEA06985.1 - 0.095 13.2 0.1 0.22 12.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain MCM PF00493.23 EEA06985.1 - 0.1 11.6 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 MCM P-loop domain G-alpha PF00503.20 EEA06985.1 - 0.11 11.7 0.6 0.35 10.0 0.2 1.8 1 1 0 2 2 2 0 G-protein alpha subunit NACHT PF05729.12 EEA06985.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DAP3 PF10236.9 EEA06985.1 - 0.13 11.4 0.3 0.26 10.4 0.1 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 EEA06985.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 EEA06985.1 - 0.13 12.2 0.0 0.53 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EEA06985.1 - 0.14 12.7 0.2 0.3 11.6 0.2 1.8 1 1 0 1 1 1 0 ABC transporter RuvB_N PF05496.12 EEA06985.1 - 0.16 11.7 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Rad51 PF08423.11 EEA06986.1 - 3.3e-117 390.3 0.4 5e-117 389.7 0.1 1.4 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 EEA06986.1 - 9.1e-11 41.7 0.1 1.4e-10 41.1 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EEA06986.1 - 3.4e-07 30.0 0.0 6.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EEA06986.1 - 1e-05 26.0 1.1 2.3e-05 24.9 1.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA PF00004.29 EEA06986.1 - 0.0016 18.9 0.3 0.015 15.7 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EEA06986.1 - 0.0061 15.9 1.8 0.0064 15.9 0.3 2.0 2 1 0 2 2 2 1 KaiC RNA_pol_A_CTD PF03118.15 EEA06986.1 - 0.012 15.4 0.7 0.025 14.3 0.7 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain HHH PF00633.23 EEA06986.1 - 0.025 14.4 0.1 0.05 13.5 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_3 PF12836.7 EEA06986.1 - 0.028 14.6 0.8 0.16 12.2 0.1 2.5 3 0 0 3 3 3 0 Helix-hairpin-helix motif HHH_6 PF14579.6 EEA06986.1 - 0.1 12.9 0.4 2.1 8.7 0.1 2.6 1 1 1 2 2 2 0 Helix-hairpin-helix motif Gln-synt_C PF00120.24 EEA06986.1 - 0.14 11.1 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain Histone PF00125.24 EEA06987.1 - 4.6e-16 59.4 0.1 6.2e-16 59.0 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EEA06987.1 - 0.00037 20.7 0.0 0.00077 19.7 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EEA06987.1 - 0.0013 19.2 0.0 0.002 18.6 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A tRNA-synt_2b PF00587.25 EEA06988.1 - 3.3e-33 115.2 0.0 5.3e-32 111.2 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EEA06988.1 - 2.7e-20 72.3 0.0 5.9e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EEA06988.1 - 1.4e-13 50.7 0.1 4.2e-13 49.2 0.1 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EEA06988.1 - 3.9e-05 23.6 0.0 0.00013 21.9 0.0 2.0 1 1 0 1 1 1 1 TGS domain HhH-GPD PF00730.25 EEA06990.1 - 9.7e-23 80.7 0.0 1.3e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EEA06990.1 - 8.9e-09 34.8 0.0 2.9e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EEA06990.1 - 0.00028 21.4 0.0 0.034 14.7 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain EndIII_4Fe-2S PF10576.9 EEA06990.1 - 0.011 16.1 5.5 0.017 15.4 5.5 1.4 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Zemlya PF17646.1 EEA06990.1 - 0.091 13.1 0.0 0.66 10.4 0.0 2.0 1 1 1 2 2 2 0 Closterovirus 1a polyprotein central region GAD-like PF08887.11 EEA06990.1 - 0.097 12.5 0.0 2.9 7.7 0.0 2.2 2 0 0 2 2 2 0 GAD-like domain LCCL PF03815.19 EEA06991.1 - 1.6e-20 73.0 0.1 1.6e-20 73.0 0.1 2.6 2 0 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.25 EEA06991.1 - 8e-09 35.7 0.1 7.7e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 F5/8 type C domain PHD PF00628.29 EEA06992.1 - 0.0034 17.3 5.9 0.0091 15.9 5.9 1.8 1 0 0 1 1 1 1 PHD-finger Desulfoferrodox PF01880.18 EEA06992.1 - 0.06 14.0 0.1 0.16 12.6 0.1 1.8 1 0 0 1 1 1 0 Desulfoferrodoxin Slu7 PF11708.8 EEA06993.1 - 1.6e-65 221.6 15.6 2.1e-65 221.2 15.6 1.2 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor PhoLip_ATPase_C PF16212.5 EEA06994.1 - 3.5e-54 184.2 30.3 3.5e-54 184.2 30.3 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA06994.1 - 1.3e-20 72.8 6.9 4.5e-20 71.1 6.9 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EEA06994.1 - 5.3e-13 49.7 0.0 9.1e-07 29.4 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA06994.1 - 2.2e-07 30.6 0.1 2.2e-07 30.6 0.1 3.3 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EEA06994.1 - 0.0017 18.4 0.0 0.0058 16.7 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA06994.1 - 0.007 16.1 1.6 0.007 16.1 1.6 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase ubiquitin PF00240.23 EEA06995.1 - 2.9e-06 26.9 0.0 4.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EEA06995.1 - 0.04 13.7 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like T4_baseplate PF12322.8 EEA06995.1 - 0.066 12.7 0.0 0.075 12.5 0.0 1.1 1 0 0 1 1 1 0 T4 bacteriophage base plate protein Xpo1 PF08389.12 EEA06996.1 - 3.6e-22 79.0 12.1 3.3e-21 75.9 0.1 4.7 4 0 0 4 4 4 3 Exportin 1-like protein ARID PF01388.21 EEA06997.1 - 3.5e-14 53.2 0.0 1.1e-13 51.7 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain MCLC PF05934.11 EEA06997.1 - 0.0059 15.4 0.0 0.0092 14.8 0.0 1.2 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) TIM21 PF08294.11 EEA06997.1 - 0.066 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 TIM21 Secapin PF17521.2 EEA06999.1 - 4.9 7.0 27.0 18 5.2 0.1 10.4 12 0 0 12 12 12 0 Honey bee peptides Glyco_trans_1_4 PF13692.6 EEA07000.1 - 0.0012 19.3 0.0 0.0025 18.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EEA07000.1 - 0.053 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EEA07000.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EEA07000.1 - 0.22 11.9 0.0 0.36 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain TRAPP PF04051.16 EEA07001.1 - 8.2e-32 109.9 0.1 9.8e-32 109.7 0.1 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component UDPGP PF01704.18 EEA07002.1 - 1.9e-20 72.9 0.0 8.5e-20 70.8 0.0 2.0 2 1 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase Pkinase PF00069.25 EEA07003.1 - 1e-71 241.4 0.0 1.4e-71 240.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07003.1 - 7.4e-29 100.8 0.0 1.3e-28 100.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 EEA07003.1 - 4.3e-18 65.5 6.9 1.3e-12 48.0 1.6 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EEA07003.1 - 1.4e-17 61.9 9.3 2.8e-06 26.5 1.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EEA07003.1 - 1.6e-17 61.9 0.9 9.3e-05 22.1 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EEA07003.1 - 2.4e-15 55.2 6.2 1.2e-05 24.6 0.1 3.5 3 0 0 3 3 3 3 EF hand CBM_20 PF00686.19 EEA07003.1 - 4.2e-12 45.8 0.6 8.8e-12 44.8 0.1 1.8 2 0 0 2 2 2 1 Starch binding domain EF-hand_8 PF13833.6 EEA07003.1 - 8.8e-12 44.7 6.2 8.5e-05 22.3 0.4 4.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 EEA07003.1 - 3e-06 27.4 0.9 0.00015 22.0 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain Kdo PF06293.14 EEA07003.1 - 0.0004 19.8 0.0 0.00081 18.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_4 PF12763.7 EEA07003.1 - 0.0067 16.4 0.5 0.078 12.9 0.4 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EEA07003.1 - 0.028 14.7 1.9 1.9 8.9 0.5 2.6 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EEA07003.1 - 0.059 13.6 0.8 0.66 10.2 0.9 2.5 1 1 1 2 2 2 0 Dockerin type I domain Choline_kinase PF01633.20 EEA07003.1 - 0.065 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 EEA07003.1 - 0.14 12.0 0.0 2.4 8.0 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family SMC_N PF02463.19 EEA07004.1 - 2.9e-73 245.9 12.6 6.8e-39 133.6 4.8 4.1 2 1 1 3 3 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA07004.1 - 3e-22 79.1 0.4 1e-21 77.4 0.1 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EEA07004.1 - 2.3e-15 57.2 15.9 1.2e-08 35.2 3.2 3.9 3 2 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EEA07004.1 - 4.2e-12 46.5 14.1 4.2e-12 46.5 14.1 5.6 1 1 2 3 3 1 1 AAA ATPase domain AAA_29 PF13555.6 EEA07004.1 - 2.1e-07 30.6 0.0 4.3e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA07004.1 - 7.3e-05 23.4 43.8 7.3e-05 23.4 43.8 8.6 1 1 4 5 5 3 1 AAA domain ABC_tran PF00005.27 EEA07004.1 - 0.0093 16.5 0.0 0.0093 16.5 0.0 7.1 3 2 0 4 4 2 2 ABC transporter DHR10 PF18595.1 EEA07004.1 - 0.01 15.9 16.8 0.01 15.9 16.8 9.1 5 2 4 9 9 8 0 Designed helical repeat protein 10 domain AAA_27 PF13514.6 EEA07004.1 - 0.064 12.8 0.1 0.064 12.8 0.1 5.6 5 2 2 7 7 7 0 AAA domain SbcCD_C PF13558.6 EEA07004.1 - 0.074 13.3 0.0 0.27 11.5 0.0 2.0 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DAHP_snth_FXD PF18152.1 EEA07004.1 - 1.6 8.7 4.5 3.5 7.5 0.2 3.6 3 0 0 3 3 3 0 DAHP synthase ferredoxin-like domain EMP24_GP25L PF01105.24 EEA07005.1 - 5.2e-16 59.1 0.1 6.3e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD UPA PF17217.3 EEA07005.1 - 0.037 13.9 0.0 0.048 13.6 0.0 1.2 1 0 0 1 1 1 0 UPA domain Pre-PUA PF17832.1 EEA07005.1 - 0.16 12.7 1.5 0.25 12.1 0.6 1.8 2 0 0 2 2 2 0 Pre-PUA-like domain Ribosomal_L44 PF00935.19 EEA07006.1 - 4.6e-33 113.5 16.3 6e-33 113.2 16.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L44 Ribosomal_L33 PF00471.20 EEA07006.1 - 2.4 8.7 11.8 1 9.8 0.8 2.9 2 1 1 3 3 3 0 Ribosomal protein L33 KH_1 PF00013.29 EEA07007.1 - 7.5e-17 60.9 10.7 2.2e-11 43.4 0.4 5.8 6 0 0 6 6 6 3 KH domain DCX PF03607.17 EEA07007.1 - 0.0043 17.1 0.2 0.97 9.6 0.0 3.3 4 0 0 4 4 4 1 Doublecortin KH_2 PF07650.17 EEA07007.1 - 0.028 14.2 1.4 0.073 12.9 0.3 2.3 2 0 0 2 2 2 0 KH domain Secretin_N PF03958.17 EEA07007.1 - 0.062 13.7 0.1 1 9.8 0.0 3.0 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain Pyr_redox_2 PF07992.14 EEA07008.1 - 3.4e-37 128.3 0.0 4.4e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EEA07008.1 - 2.9e-06 27.8 0.1 1e-05 26.0 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HGTP_anticodon2 PF12745.7 EEA07008.1 - 0.079 12.5 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Adaptin_N PF01602.20 EEA07009.1 - 1.2e-78 264.9 22.7 1.2e-78 264.9 22.7 1.4 2 0 0 2 2 2 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EEA07009.1 - 5.9e-30 104.4 0.2 3.8e-29 101.8 0.1 2.2 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EEA07009.1 - 3.3e-24 85.2 0.0 8.1e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EEA07009.1 - 1.1e-09 38.6 0.2 3.5e-05 24.1 0.0 4.6 4 1 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 EEA07009.1 - 1.1e-08 35.3 21.4 6.8e-07 29.5 1.2 5.6 3 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Coatomer_b_Cpla PF14806.6 EEA07009.1 - 0.051 13.5 0.5 0.82 9.7 0.0 2.9 3 0 0 3 3 3 0 Coatomer beta subunit appendage platform HEAT PF02985.22 EEA07009.1 - 0.14 12.4 8.0 44 4.7 0.1 5.8 6 0 0 6 6 6 0 HEAT repeat Sld5 PF05916.11 EEA07010.1 - 4.6e-14 52.8 0.0 7.2e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein SPT16 PF08644.11 EEA07011.1 - 2e-44 151.4 0.1 2e-44 151.4 0.1 2.9 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EEA07011.1 - 2.8e-26 92.3 1.0 1.1e-25 90.3 0.0 2.6 3 0 0 3 3 3 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EEA07011.1 - 2.7e-21 76.2 0.0 4.2e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EEA07011.1 - 2.3e-18 66.4 0.0 8.9e-18 64.5 0.0 2.1 1 0 0 1 1 1 1 Histone chaperone Rttp106-like GAS PF13851.6 EEA07012.1 - 0.02 14.2 31.0 0.051 12.9 0.7 3.3 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding PspA_IM30 PF04012.12 EEA07012.1 - 6.7 6.2 12.6 2.4 7.7 6.4 2.5 2 1 1 3 3 3 0 PspA/IM30 family DUF4407 PF14362.6 EEA07012.1 - 7 5.9 7.3 0.98 8.7 3.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Polyketide_cyc PF03364.20 EEA07013.1 - 8.1e-13 48.7 0.0 1.9e-12 47.5 0.0 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF1106 PF06523.11 EEA07013.1 - 0.046 13.8 1.1 0.062 13.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1106) Ribosomal_S5_C PF03719.15 EEA07014.1 - 0.01 15.2 0.4 0.022 14.2 0.4 1.5 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain NPL4 PF05021.15 EEA07015.1 - 3.9e-29 102.0 0.0 4.2e-27 95.3 0.0 2.8 1 1 0 1 1 1 1 NPL4 family UN_NPL4 PF11543.8 EEA07015.1 - 2.4e-17 63.2 0.1 5.7e-17 62.0 0.1 1.6 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-NPL4 PF05020.15 EEA07015.1 - 1.3e-05 25.3 0.0 2.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region ubiquitin PF00240.23 EEA07015.1 - 0.00033 20.3 0.0 0.00071 19.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Tubulin PF00091.25 EEA07016.1 - 1.1e-66 224.7 0.0 2.7e-66 223.5 0.0 1.7 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA07016.1 - 1.1e-43 148.5 0.7 2.4e-43 147.3 0.7 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EEA07016.1 - 0.0001 22.6 0.0 0.00027 21.2 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Hrs_helical PF12210.8 EEA07016.1 - 0.0038 17.7 0.1 0.01 16.3 0.1 1.7 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate Tubulin_2 PF13809.6 EEA07016.1 - 0.011 15.0 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Ribosomal_L7Ae PF01248.26 EEA07017.1 - 7.8e-07 28.7 0.3 3.1e-06 26.8 0.1 2.0 2 1 1 3 3 3 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pkinase PF00069.25 EEA07018.1 - 9.2e-11 41.6 0.4 1.7e-09 37.5 0.3 2.6 1 1 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EEA07019.1 - 0.0029 17.7 0.3 12 6.5 0.0 3.9 3 0 0 3 3 3 2 HEAT repeat DUF29 PF01724.16 EEA07019.1 - 0.023 14.9 4.1 0.046 13.9 4.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF29 DUF1601 PF07671.11 EEA07019.1 - 0.026 14.4 1.1 0.026 14.4 1.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1601) Vac14_Fab1_bd PF12755.7 EEA07019.1 - 0.094 13.3 5.0 4.7 7.9 0.0 3.3 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region Reticulon PF02453.17 EEA07020.1 - 1.7e-06 28.1 7.2 2.3e-06 27.6 7.2 1.3 1 0 0 1 1 1 1 Reticulon AAA_lid_2 PF17863.1 EEA07020.1 - 0.0019 18.0 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA lid domain COPI_assoc PF08507.10 EEA07020.1 - 0.051 13.6 0.5 0.051 13.6 0.5 2.2 2 0 0 2 2 2 0 COPI associated protein DUF2729 PF10870.8 EEA07020.1 - 3.2 7.7 0.0 3.2 7.7 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2729) SIR2 PF02146.17 EEA07021.1 - 1.8e-23 83.4 0.0 2.2e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EEA07021.1 - 0.011 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain LSM PF01423.22 EEA07022.1 - 3e-17 62.0 0.1 3.5e-17 61.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA07022.1 - 6.3e-06 26.2 0.0 7.8e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EEA07022.1 - 0.0022 18.0 0.1 0.0025 17.9 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain Aha1_N PF09229.11 EEA07023.1 - 4.1e-38 130.7 6.4 5.3e-23 81.7 0.0 2.4 3 0 0 3 3 3 2 Activator of Hsp90 ATPase, N-terminal FXMR_C2 PF16098.5 EEA07023.1 - 0.091 13.3 1.2 1.8 9.2 0.0 2.4 2 0 0 2 2 2 0 Fragile X-related mental retardation protein C-terminal region 2 MCM_N PF14551.6 EEA07023.1 - 1 10.0 4.5 1.5 9.4 0.2 2.6 1 1 1 2 2 2 0 MCM N-terminal domain Metallophos_2 PF12850.7 EEA07024.1 - 3.8e-18 66.2 0.0 4.6e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EEA07024.1 - 0.019 15.5 0.4 0.42 11.1 0.4 2.2 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase Swi3 PF07962.12 EEA07025.1 - 0.00028 20.8 2.9 0.39 10.7 0.0 3.8 3 0 0 3 3 3 3 Replication Fork Protection Component Swi3 Peptidase_M16_C PF05193.21 EEA07026.1 - 1.1e-26 93.9 0.0 3.5e-26 92.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA07026.1 - 2e-22 79.8 0.2 9.7e-22 77.6 0.0 2.2 2 1 1 3 3 3 1 Insulinase (Peptidase family M16) RAI1 PF08652.11 EEA07026.1 - 0.15 12.2 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease TIP49 PF06068.13 EEA07027.1 - 1.8e-160 533.9 0.1 2.2e-160 533.6 0.1 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EEA07027.1 - 8.6e-22 77.0 0.0 3e-21 75.3 0.0 2.0 2 0 0 2 2 1 1 TIP49 AAA-lid domain AAA PF00004.29 EEA07027.1 - 2.4e-11 44.2 0.1 3e-07 30.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EEA07027.1 - 4.2e-09 36.3 0.0 9.4e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EEA07027.1 - 5.6e-07 29.9 0.0 0.0026 18.0 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EEA07027.1 - 0.00023 21.2 0.0 0.029 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EEA07027.1 - 0.00065 20.0 0.2 1.3 9.3 0.1 2.3 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EEA07027.1 - 0.00079 18.9 0.2 0.033 13.6 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EEA07027.1 - 0.001 18.7 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA07027.1 - 0.0014 19.0 0.0 0.006 17.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 EEA07027.1 - 0.0029 17.3 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 EEA07027.1 - 0.0068 16.7 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EEA07027.1 - 0.0068 15.9 0.1 0.026 14.0 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EEA07027.1 - 0.0082 15.9 0.1 0.016 14.9 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_11 PF13086.6 EEA07027.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EEA07027.1 - 0.015 14.8 0.1 0.03 13.8 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 EEA07027.1 - 0.023 13.8 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ResIII PF04851.15 EEA07027.1 - 0.042 13.8 0.1 0.78 9.7 0.0 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EEA07027.1 - 0.043 13.1 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 EEA07027.1 - 0.047 13.9 0.0 0.093 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EEA07027.1 - 0.056 12.8 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_18 PF13238.6 EEA07027.1 - 0.061 13.9 0.0 0.34 11.5 0.0 2.1 1 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EEA07027.1 - 0.15 11.3 0.1 0.32 10.2 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 EEA07027.1 - 0.15 11.7 0.1 5.2 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rubredoxin_C PF18267.1 EEA07028.1 - 0.0067 16.3 0.1 7.4 6.6 0.0 2.8 2 0 0 2 2 2 2 Rubredoxin NAD+ reductase C-terminal domain Ribosomal_L2_C PF03947.18 EEA07029.1 - 7e-44 149.1 3.8 1e-43 148.5 3.8 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EEA07029.1 - 3.3e-15 55.8 0.2 1.8e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Trm5_N PF18093.1 EEA07030.1 - 0.18 11.7 0.3 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 tRNA methyltransferase 5 N-terminal domain XPG_I PF00867.18 EEA07032.1 - 2.3e-30 104.8 0.0 2.3e-30 104.8 0.0 3.1 3 1 0 3 3 3 1 XPG I-region XPG_N PF00752.17 EEA07032.1 - 1.8e-29 102.2 0.0 4.2e-29 101.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc_N PF02739.16 EEA07032.1 - 8.2e-05 22.6 0.0 0.00037 20.4 0.0 2.1 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 EEA07032.1 - 0.00037 21.1 0.0 0.00037 21.1 0.0 3.2 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold EMP24_GP25L PF01105.24 EEA07033.1 - 8.3e-31 107.3 1.5 9.5e-31 107.1 1.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD AhpC-TSA PF00578.21 EEA07034.1 - 5.4e-31 107.1 0.0 2.3e-27 95.4 0.0 2.1 1 1 1 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 EEA07034.1 - 9.5e-13 48.1 0.0 6e-12 45.5 0.0 1.9 1 1 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EEA07034.1 - 7e-06 25.8 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin PRP21_like_P PF12230.8 EEA07035.1 - 2.6e-47 161.5 9.4 2.6e-47 161.5 9.4 1.7 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EEA07035.1 - 2.2e-38 130.0 3.8 2.1e-18 66.1 0.1 3.6 3 0 0 3 3 3 2 Surp module Atx10homo_assoc PF09759.9 EEA07037.1 - 4.1e-10 39.6 0.7 4.1e-10 39.6 0.7 2.2 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Guanylate_kin PF00625.21 EEA07039.1 - 4.1e-48 163.5 0.1 5e-48 163.2 0.1 1.0 1 0 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.23 EEA07039.1 - 1.2e-05 25.3 0.1 9e-05 22.5 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EEA07039.1 - 2.9e-05 24.4 0.0 4.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EEA07039.1 - 0.00015 21.7 0.0 0.00026 20.9 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 EEA07039.1 - 0.0003 21.3 0.5 0.00067 20.2 0.5 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA07039.1 - 0.00032 20.9 0.0 0.0012 19.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EEA07039.1 - 0.002 18.5 0.0 0.0035 17.7 0.0 1.5 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 EEA07039.1 - 0.0036 17.8 0.2 0.005 17.3 0.1 1.5 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EEA07039.1 - 0.0059 17.0 0.0 0.012 16.0 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 EEA07039.1 - 0.0093 15.9 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 EEA07039.1 - 0.011 15.7 0.9 0.037 14.1 0.1 2.2 1 1 0 2 2 2 0 AAA domain Septin PF00735.18 EEA07039.1 - 0.019 14.3 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_23 PF13476.6 EEA07039.1 - 0.022 15.3 1.0 0.8 10.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA07039.1 - 0.032 14.0 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EEA07039.1 - 0.04 14.1 0.0 0.088 13.0 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EEA07039.1 - 0.047 13.6 1.6 0.088 12.7 1.6 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 EEA07039.1 - 0.063 13.3 0.2 0.077 13.0 0.2 1.7 1 1 0 1 1 1 0 Dynamin family Ras PF00071.22 EEA07039.1 - 0.075 12.6 0.1 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 Ras family AAA_7 PF12775.7 EEA07039.1 - 0.1 12.1 0.0 0.25 10.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 EEA07039.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase MobB PF03205.14 EEA07039.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 EEA07039.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EEA07039.1 - 0.15 11.8 0.4 1.5 8.5 0.1 2.2 1 1 1 2 2 2 0 AAA domain FeThRed_B PF02943.15 EEA07039.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain AAA_28 PF13521.6 EEA07039.1 - 0.17 12.1 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TTKRSYEDQ PF10212.9 EEA07042.1 - 0.00043 19.4 11.0 0.00043 19.4 11.0 3.3 3 1 1 4 4 4 1 Predicted coiled-coil domain-containing protein SHE3 PF17078.5 EEA07042.1 - 0.00057 19.7 17.0 0.00057 19.7 17.0 4.9 5 0 0 5 5 5 1 SWI5-dependent HO expression protein 3 DUF3450 PF11932.8 EEA07042.1 - 0.0056 16.0 4.6 0.0056 16.0 4.6 5.0 4 1 1 5 5 5 1 Protein of unknown function (DUF3450) DUF1818 PF08848.11 EEA07042.1 - 1.4 9.0 9.0 5.9 7.0 0.4 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF1818) T3SSipB PF16535.5 EEA07042.1 - 3.2 8.2 16.2 0.61 10.6 1.1 3.6 3 1 0 3 3 3 0 Type III cell invasion protein SipB Ribosomal_S3_C PF00189.20 EEA07044.1 - 1.9e-26 92.4 0.8 8.3e-26 90.3 1.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EEA07044.1 - 1.7e-09 37.4 0.0 2.8e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 KH domain DUF1682 PF07946.14 EEA07045.1 - 6.7e-80 268.7 4.9 7.9e-80 268.5 4.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) GNT-I PF03071.15 EEA07045.1 - 0.42 9.3 5.5 0.81 8.4 5.5 1.4 1 0 0 1 1 1 0 GNT-I family Asp-B-Hydro_N PF05279.11 EEA07045.1 - 1.2 9.1 6.2 1.7 8.7 6.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region ubiquitin PF00240.23 EEA07047.1 - 5.2e-35 119.0 0.3 6.9e-35 118.6 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EEA07047.1 - 1.1e-28 98.8 10.9 1.7e-28 98.2 10.9 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EEA07047.1 - 4.3e-17 61.7 0.4 7.5e-17 60.9 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EEA07047.1 - 5.2e-06 26.8 0.1 2e-05 25.0 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EEA07047.1 - 0.0035 17.3 0.0 0.0046 16.9 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EEA07047.1 - 0.0039 17.3 0.0 0.0081 16.3 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EEA07047.1 - 0.0055 17.0 0.0 0.0099 16.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EEA07047.1 - 0.021 14.9 0.7 6.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EEA07047.1 - 0.049 14.2 0.0 0.056 14.0 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Fcf1 PF04900.12 EEA07048.1 - 2.5e-36 124.0 1.5 4.5e-36 123.2 1.5 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EEA07048.1 - 1.5e-12 47.8 0.0 3e-12 46.9 0.0 1.4 2 0 0 2 2 2 1 PIN like domain Imm-NTF2 PF15655.6 EEA07048.1 - 0.1 12.9 0.2 0.22 11.8 0.0 1.6 2 0 0 2 2 2 0 NTF2 fold immunity protein DUF4652 PF15525.6 EEA07048.1 - 0.39 10.5 3.4 0.58 9.9 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4652) eIF-5a PF01287.20 EEA07049.1 - 6.7e-24 83.8 0.0 9.7e-24 83.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EEA07049.1 - 0.0034 17.4 0.0 0.0053 16.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain AAA PF00004.29 EEA07050.1 - 2.6e-08 34.4 1.7 3.6e-07 30.7 1.7 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA07050.1 - 4e-05 23.9 1.2 0.0003 21.1 0.3 2.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA07050.1 - 0.0001 22.7 0.0 0.0004 20.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_lid_10 PF17872.1 EEA07050.1 - 0.0002 21.4 0.0 0.0002 21.4 0.0 3.1 4 0 0 4 4 4 1 AAA lid domain AAA_19 PF13245.6 EEA07050.1 - 0.0066 16.8 0.0 0.018 15.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EEA07050.1 - 0.013 15.5 0.1 5 7.0 0.0 2.7 3 0 0 3 3 3 0 NACHT domain AAA_7 PF12775.7 EEA07050.1 - 0.015 14.8 0.1 0.19 11.2 0.0 2.4 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EEA07050.1 - 0.016 15.2 0.0 0.45 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EEA07050.1 - 0.032 13.6 0.4 0.09 12.1 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EEA07050.1 - 0.04 13.8 0.5 0.2 11.6 0.0 2.5 2 0 0 2 2 2 0 NTPase Myb_DNA-bind_3 PF12776.7 EEA07050.1 - 4.5 8.3 5.8 17 6.5 0.0 3.9 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain Thioesterase PF00975.20 EEA07051.1 - 8.7e-06 26.0 0.0 0.0057 16.8 0.0 2.3 2 1 0 2 2 2 2 Thioesterase domain Hydrolase_4 PF12146.8 EEA07051.1 - 4.7e-05 22.8 0.0 6.5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EEA07051.1 - 0.00053 20.7 0.0 0.00057 20.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EEA07051.1 - 0.0078 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase PGAP1 PF07819.13 EEA07051.1 - 0.0079 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 EEA07051.1 - 0.044 12.9 0.1 0.086 12.0 0.1 1.5 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Arf PF00025.21 EEA07052.1 - 1.8e-63 213.1 0.0 2e-63 213.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EEA07052.1 - 2.6e-13 49.9 0.7 3.3e-10 39.7 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EEA07052.1 - 1.9e-12 47.0 0.0 2.3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EEA07052.1 - 4.8e-10 39.3 0.0 5.7e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07052.1 - 9.4e-10 38.7 0.0 2.4e-09 37.5 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA07052.1 - 4.6e-08 33.1 0.0 6.2e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA07052.1 - 9.3e-07 28.4 0.0 1.1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA07052.1 - 0.00013 21.6 0.0 0.0024 17.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EEA07052.1 - 0.065 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NOG1 PF06858.14 EEA07052.1 - 0.13 12.1 0.0 0.29 10.9 0.0 1.6 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) cobW PF02492.19 EEA07052.1 - 0.17 11.5 0.0 5.3 6.6 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain UL45 PF05473.12 EEA07054.1 - 0.019 14.6 0.1 0.03 14.0 0.0 1.4 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Zip PF02535.22 EEA07054.1 - 1.1 8.4 10.5 1.3 8.2 10.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EEA07054.1 - 1.7 7.3 5.8 2 7.1 5.8 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EEA07054.1 - 2.5 7.0 9.4 2.9 6.8 9.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Peptidase_S49_N PF08496.10 EEA07054.1 - 3.6 7.6 8.5 0.49 10.5 4.1 1.7 1 1 1 2 2 2 0 Peptidase family S49 N-terminal Macoilin PF09726.9 EEA07054.1 - 9.3 4.7 13.3 11 4.5 13.3 1.0 1 0 0 1 1 1 0 Macoilin family CDC50 PF03381.15 EEA07056.1 - 2.5e-18 66.6 4.5 6.5e-17 61.9 4.5 2.4 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family EB1 PF03271.17 EEA07057.1 - 3.1e-13 49.7 1.2 7e-13 48.6 0.4 2.1 1 1 1 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 EEA07057.1 - 2.5e-07 30.8 0.9 4.1e-07 30.2 0.2 1.7 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 EEA07057.1 - 0.023 14.8 2.0 0.033 14.3 0.6 2.0 2 0 0 2 2 2 0 CH-like domain in sperm protein DUF900 PF05990.12 EEA07057.1 - 0.1 12.1 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) RNase_PH PF01138.21 EEA07058.1 - 1.7e-15 57.7 0.1 1.8e-14 54.4 0.0 2.3 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EEA07058.1 - 6.1e-10 39.0 0.6 5.8e-09 35.9 0.0 2.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Tyr-DNA_phospho PF06087.12 EEA07059.1 - 4.1e-75 253.3 3.8 5.2e-75 253.0 3.8 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase DUF5595 PF18077.1 EEA07060.1 - 0.0031 17.5 0.1 0.0073 16.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5595) Cpn10 PF00166.21 EEA07061.1 - 3e-21 75.3 0.0 4e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit ARD PF03079.14 EEA07061.1 - 0.096 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family zf-NOSIP PF15906.5 EEA07062.1 - 0.0094 16.1 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Ribosomal_L22e PF01776.17 EEA07063.1 - 1.3e-45 154.3 0.2 1.4e-45 154.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family eIF-5_eIF-2B PF01873.17 EEA07064.1 - 8.5e-36 122.4 0.5 2.3e-35 121.0 0.0 2.0 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.18 EEA07064.1 - 4.4e-15 55.6 0.0 1.4e-14 54.0 0.0 1.8 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon zinc_ribbon_4 PF13717.6 EEA07064.1 - 1.8 8.6 5.3 7.9 6.5 5.3 2.0 1 1 0 1 1 1 0 zinc-ribbon domain Tho2 PF11262.8 EEA07065.1 - 1.1e-18 67.5 3.5 3.5e-18 65.8 3.5 2.0 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EEA07065.1 - 1.4e-06 28.2 1.5 1.4e-06 28.2 1.5 2.7 3 0 0 3 3 3 1 Transcription- and export-related complex subunit RNA_capsid PF03035.14 EEA07065.1 - 0.12 12.4 3.4 0.21 11.6 3.4 1.4 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein MFS_1 PF07690.16 EEA07066.1 - 8.6e-10 38.1 29.0 8.6e-10 38.1 29.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RabGAP-TBC PF00566.18 EEA07067.1 - 7.8e-15 55.1 13.9 7.8e-15 55.1 13.9 2.0 2 1 1 3 3 3 1 Rab-GTPase-TBC domain 14-3-3 PF00244.20 EEA07068.1 - 7.1e-32 110.7 9.7 8e-32 110.5 9.7 1.0 1 0 0 1 1 1 1 14-3-3 protein DNase-RNase PF02577.14 EEA07068.1 - 0.0027 17.3 0.4 0.044 13.4 0.4 2.2 1 1 0 1 1 1 1 Bifunctional nuclease Latarcin PF10279.9 EEA07068.1 - 0.074 13.5 0.0 0.34 11.3 0.0 2.3 1 1 0 1 1 1 0 Latarcin precursor GP41 PF00517.17 EEA07069.1 - 0.71 9.7 12.6 1 9.2 2.0 2.6 1 1 1 2 2 2 0 Retroviral envelope protein zf-HIT PF04438.16 EEA07070.1 - 5e-05 23.1 16.4 5e-05 23.1 16.4 1.8 2 0 0 2 2 2 1 HIT zinc finger Cyclin PF08613.11 EEA07071.1 - 3.1e-17 63.4 0.1 4.9e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin Skp1 PF01466.19 EEA07072.1 - 9.6e-26 89.7 1.1 9.6e-26 89.7 1.1 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EEA07072.1 - 4.5e-25 87.6 1.2 6.3e-25 87.1 0.2 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF4131 PF13567.6 EEA07073.1 - 1.6 8.4 6.5 1.2 8.7 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF1240 PF06836.12 EEA07073.1 - 2 9.0 11.8 0.65 10.6 0.2 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF1240) SbmA_BacA PF05992.12 EEA07074.1 - 0.00021 20.8 0.1 0.00043 19.8 0.1 1.4 1 1 0 1 1 1 1 SbmA/BacA-like family Ribosomal_L35Ae PF01247.18 EEA07077.1 - 6.5e-38 128.8 0.4 8.3e-38 128.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae Hydrolase_4 PF12146.8 EEA07078.1 - 4.3e-12 45.8 0.0 9.5e-12 44.7 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA07078.1 - 2.2e-09 37.3 0.1 2e-06 27.6 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA07078.1 - 3.9e-05 24.4 0.0 5.9e-05 23.8 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EEA07078.1 - 0.00013 21.6 0.0 0.00044 19.9 0.0 1.7 1 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EEA07078.1 - 0.019 14.5 0.0 0.089 12.3 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family LIDHydrolase PF10230.9 EEA07078.1 - 0.098 12.2 0.0 12 5.3 0.0 2.1 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase FtsJ PF01728.19 EEA07080.1 - 8.8e-24 84.6 0.0 3.3e-22 79.5 0.0 2.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase PS_pyruv_trans PF04230.13 EEA07081.1 - 1.8e-20 74.1 2.1 1.5e-14 54.6 1.3 2.4 2 0 0 2 2 2 2 Polysaccharide pyruvyl transferase TPT PF03151.16 EEA07082.1 - 1.6e-10 40.8 19.4 3.6e-09 36.4 17.9 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EEA07082.1 - 6e-05 23.2 30.7 6.8e-05 23.1 5.8 4.1 4 1 0 4 4 4 2 EamA-like transporter family RPGR1_C PF18111.1 EEA07083.1 - 0.052 13.4 0.8 0.4 10.6 0.4 2.4 2 0 0 2 2 2 0 Retinitis pigmentosa G-protein regulator interacting C-terminal DUF1825 PF08855.10 EEA07083.1 - 0.06 13.3 0.3 0.19 11.7 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) Kelch_1 PF01344.25 EEA07084.1 - 1.5e-30 104.5 2.3 3e-10 39.5 0.0 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EEA07084.1 - 4.8e-23 80.6 3.1 2e-05 24.7 0.0 6.2 4 1 2 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EEA07084.1 - 1.6e-20 72.9 2.9 0.00021 21.2 0.0 5.9 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB_2 PF02214.22 EEA07084.1 - 6e-15 55.4 0.8 1.8e-14 53.9 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 EEA07084.1 - 4.2e-09 36.5 5.0 0.072 13.4 0.0 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EEA07084.1 - 1.5e-07 31.1 6.1 0.39 10.8 0.0 5.6 5 0 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.11 EEA07084.1 - 2.7e-05 23.5 0.1 0.002 17.4 0.0 2.3 1 1 0 2 2 2 1 Glyoxal oxidase N-terminus Ubiquitin_4 PF18036.1 EEA07084.1 - 0.16 12.0 3.6 0.42 10.7 3.6 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain FapA PF03961.13 EEA07084.1 - 0.23 10.0 11.6 0.34 9.5 11.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 EEA07084.1 - 2 7.9 9.2 2.8 7.4 9.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_2 PF07724.14 EEA07085.1 - 1.5e-30 106.5 0.1 1.5e-26 93.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 EEA07085.1 - 2e-27 96.2 0.4 3.9e-17 62.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_9 PF17871.1 EEA07085.1 - 3.8e-17 62.1 0.1 1.1e-16 60.7 0.1 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_5 PF07728.14 EEA07085.1 - 4.9e-14 52.5 0.0 8.1e-06 25.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA07085.1 - 4.7e-12 46.6 2.3 1.9e-06 28.4 0.1 4.2 2 2 0 3 3 3 2 AAA ATPase domain ClpB_D2-small PF10431.9 EEA07085.1 - 2.4e-09 37.1 0.7 1e-08 35.1 0.0 2.4 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein IstB_IS21 PF01695.17 EEA07085.1 - 2.5e-08 33.9 0.1 0.00073 19.3 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 EEA07085.1 - 2.7e-08 34.2 0.5 0.0012 19.1 0.1 3.6 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EEA07085.1 - 7.1e-08 33.1 2.5 6.1e-05 23.6 0.0 3.6 3 0 0 3 3 2 1 AAA domain TniB PF05621.11 EEA07085.1 - 8.5e-08 31.8 0.1 0.19 11.2 0.0 4.4 4 0 0 4 4 4 1 Bacterial TniB protein RuvB_N PF05496.12 EEA07085.1 - 1.1e-07 31.8 0.1 0.015 15.0 0.0 3.4 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EEA07085.1 - 2.1e-07 30.5 0.1 0.00095 18.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EEA07085.1 - 7.5e-07 28.7 0.4 0.0005 19.4 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_28 PF13521.6 EEA07085.1 - 4.9e-06 26.9 2.0 0.00027 21.2 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EEA07085.1 - 5.5e-06 26.0 0.2 0.016 14.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 EEA07085.1 - 6.3e-06 26.4 0.3 0.0028 17.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EEA07085.1 - 9.1e-06 26.0 3.0 0.077 13.4 0.0 4.4 5 0 0 5 5 2 2 RNA helicase TsaE PF02367.17 EEA07085.1 - 6.9e-05 22.8 0.4 0.11 12.5 0.0 3.2 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EEA07085.1 - 9.6e-05 22.1 0.3 0.62 9.8 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 EEA07085.1 - 0.00011 22.2 0.8 0.0067 16.5 0.0 3.8 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EEA07085.1 - 0.00012 21.7 1.8 0.16 11.4 0.0 3.4 3 0 0 3 3 3 1 PhoH-like protein AAA_24 PF13479.6 EEA07085.1 - 0.00023 21.0 0.2 0.067 12.9 0.1 2.7 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EEA07085.1 - 0.00024 21.1 0.7 0.89 9.4 0.1 2.7 2 0 0 2 2 2 2 NTPase T2SSE PF00437.20 EEA07085.1 - 0.00024 20.3 0.3 0.22 10.5 0.1 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein NACHT PF05729.12 EEA07085.1 - 0.00028 20.9 0.2 0.048 13.6 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 EEA07085.1 - 0.0003 20.4 0.2 0.038 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EEA07085.1 - 0.00031 20.4 0.1 0.45 10.3 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EEA07085.1 - 0.00035 20.4 0.8 0.076 12.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EEA07085.1 - 0.00048 20.2 0.6 1.4 8.9 0.0 3.7 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit PduV-EutP PF10662.9 EEA07085.1 - 0.00063 19.5 1.3 0.08 12.7 0.0 3.0 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation DEAD PF00270.29 EEA07085.1 - 0.00064 19.5 0.3 0.04 13.7 0.0 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase ABC_tran PF00005.27 EEA07085.1 - 0.00085 19.8 3.6 0.11 13.0 0.1 3.1 3 0 0 3 3 2 1 ABC transporter Roc PF08477.13 EEA07085.1 - 0.0012 19.1 0.7 0.59 10.4 0.0 3.4 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EEA07085.1 - 0.0012 18.8 1.0 1.3 8.9 0.0 3.0 3 0 0 3 3 2 1 RsgA GTPase ATPase_2 PF01637.18 EEA07085.1 - 0.0022 18.0 12.0 0.094 12.6 0.0 5.5 4 3 1 5 5 4 1 ATPase domain predominantly from Archaea DNA_pol3_delta2 PF13177.6 EEA07085.1 - 0.0023 17.7 0.0 0.097 12.4 0.0 2.9 3 0 0 3 3 2 1 DNA polymerase III, delta subunit Parvo_NS1 PF01057.17 EEA07085.1 - 0.0043 16.2 0.0 0.26 10.3 0.0 2.6 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 EEA07085.1 - 0.0045 16.8 0.0 6.3 6.7 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EEA07085.1 - 0.0093 15.2 0.2 0.89 8.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain SRP54 PF00448.22 EEA07085.1 - 0.013 15.2 1.8 0.61 9.7 0.1 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EEA07085.1 - 0.013 15.8 4.0 0.35 11.2 0.1 3.0 3 1 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.23 EEA07085.1 - 0.014 15.4 0.1 1.7 8.8 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_11 PF13086.6 EEA07085.1 - 0.019 14.7 2.9 0.22 11.3 0.0 3.0 3 1 0 3 3 2 0 AAA domain SRPRB PF09439.10 EEA07085.1 - 0.046 13.1 3.4 0.34 10.3 0.0 3.6 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit DUF2075 PF09848.9 EEA07085.1 - 0.062 12.5 0.0 0.17 11.1 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MeaB PF03308.16 EEA07085.1 - 0.068 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_6 PF12774.7 EEA07085.1 - 0.08 11.9 1.1 32 3.3 0.1 3.6 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region AAA_17 PF13207.6 EEA07085.1 - 0.11 13.0 3.6 0.66 10.4 0.0 3.4 4 0 0 4 4 2 0 AAA domain Sigma54_activ_2 PF14532.6 EEA07085.1 - 0.12 12.5 0.1 2.7 8.1 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain TrwB_AAD_bind PF10412.9 EEA07085.1 - 0.14 11.1 0.3 20 4.0 0.0 2.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 EEA07085.1 - 0.17 11.1 0.6 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 EEA07085.1 - 0.55 10.0 3.5 18 5.0 0.0 3.1 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein Patatin PF01734.22 EEA07086.1 - 2.2e-05 24.8 0.1 0.0014 18.8 0.1 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase TPR_19 PF14559.6 EEA07087.1 - 1.5e-13 51.0 0.4 5e-06 26.9 0.1 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA07087.1 - 6.7e-06 26.5 0.2 1.2 10.1 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA07087.1 - 2.5e-05 24.4 0.4 0.17 12.1 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 PknG_TPR PF16918.5 EEA07087.1 - 3.2e-05 22.8 0.0 7e-05 21.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat TPR_17 PF13431.6 EEA07087.1 - 5.4e-05 23.3 0.1 0.11 12.9 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA07087.1 - 0.00023 21.0 0.6 3.2 8.1 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EEA07087.1 - 0.0013 19.4 0.0 0.033 14.8 0.0 2.7 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 EEA07087.1 - 0.0021 18.5 0.0 5.5 7.9 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA07087.1 - 0.014 15.6 1.0 2.2 8.7 0.1 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat L27_1 PF09058.10 EEA07087.1 - 0.034 14.1 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 L27_1 DUF4795 PF16043.5 EEA07087.1 - 0.087 12.4 2.2 0.092 12.3 0.3 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) TPR_8 PF13181.6 EEA07087.1 - 1.2 9.5 6.2 10 6.6 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat S-AdoMet_synt_C PF02773.16 EEA07088.1 - 1.8e-58 196.4 0.0 3e-58 195.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EEA07088.1 - 6.2e-42 142.6 0.0 1.2e-41 141.8 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EEA07088.1 - 5.3e-41 139.3 0.3 9.7e-41 138.5 0.3 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain CadC_C1 PF18500.1 EEA07088.1 - 0.024 14.8 0.1 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 CadC C-terminal domain 1 Rad17 PF03215.15 EEA07089.1 - 7e-09 35.9 0.3 3.8e-07 30.2 0.0 2.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA PF00004.29 EEA07089.1 - 0.0016 18.9 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EEA07089.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EEA07089.1 - 0.025 14.9 0.0 0.061 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EEA07089.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EEA07089.1 - 0.2 11.8 0.0 0.63 10.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain Metallophos PF00149.28 EEA07090.1 - 2.7e-41 142.3 0.5 3.4e-41 142.0 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA07090.1 - 2.5e-22 79.1 0.1 6.2e-22 77.8 0.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Adap_comp_sub PF00928.21 EEA07091.1 - 8.9e-83 277.7 1.1 1.1e-82 277.4 1.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EEA07091.1 - 3.7e-07 30.2 2.2 6.8e-07 29.3 2.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain GIDA PF01134.22 EEA07092.1 - 0.048 12.7 0.0 0.07 12.2 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FCH PF00611.23 EEA07092.1 - 0.093 13.0 0.3 0.64 10.3 0.1 2.4 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Phage_holin_5_2 PF16079.5 EEA07092.1 - 0.16 12.3 0.0 0.66 10.3 0.0 1.9 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Hydrolase_3 PF08282.12 EEA07092.1 - 0.52 10.0 4.5 0.24 11.1 0.5 2.1 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase UBA_3 PF09288.10 EEA07092.1 - 5.1 7.0 9.0 14 5.5 0.2 4.0 4 1 0 4 4 4 0 Fungal ubiquitin-associated domain SMC_N PF02463.19 EEA07093.1 - 4.1e-46 157.2 30.6 1.3e-45 155.6 30.6 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA07093.1 - 3.6e-23 82.1 0.3 1.2e-22 80.4 0.3 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EEA07093.1 - 9.1e-15 55.2 26.1 9.1e-15 55.2 26.1 5.7 1 1 3 4 4 4 1 AAA ATPase domain AAA_21 PF13304.6 EEA07093.1 - 1.7e-11 44.5 4.3 1.1e-06 28.7 1.5 4.7 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Sec34 PF04136.15 EEA07093.1 - 0.00018 21.4 5.5 0.00018 21.4 5.5 9.6 6 4 4 10 10 10 1 Sec34-like family AAA_29 PF13555.6 EEA07093.1 - 0.00083 19.0 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EEA07093.1 - 0.00098 19.7 0.0 0.00098 19.7 0.0 6.5 4 2 1 5 5 5 1 ABC transporter DUF1192 PF06698.11 EEA07093.1 - 3.7 7.7 14.6 37 4.5 0.4 5.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) DCP2 PF05026.13 EEA07094.1 - 7.7e-19 67.8 3.2 1.5e-18 66.9 3.2 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EEA07094.1 - 5.5e-10 39.4 0.1 1.1e-09 38.4 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain Bromodomain PF00439.25 EEA07095.1 - 7.6e-20 70.8 0.3 7.6e-20 70.8 0.3 3.2 5 0 0 5 5 5 1 Bromodomain DUF5097 PF17020.5 EEA07095.1 - 0.026 14.9 0.2 0.026 14.9 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5097) ABC_membrane_2 PF06472.15 EEA07096.1 - 2.9e-36 125.3 10.0 3.1e-36 125.2 9.0 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EEA07096.1 - 2.6e-17 63.6 0.0 6.2e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SbmA_BacA PF05992.12 EEA07096.1 - 6e-06 25.9 5.5 1.9e-05 24.3 5.5 1.8 1 1 0 1 1 1 1 SbmA/BacA-like family AAA_29 PF13555.6 EEA07096.1 - 0.00039 20.1 0.0 0.00088 19.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EEA07096.1 - 0.013 14.9 0.4 0.72 9.2 0.2 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EEA07096.1 - 0.015 15.8 1.3 0.023 15.2 0.0 2.1 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EEA07096.1 - 0.023 14.6 0.2 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EEA07096.1 - 0.034 14.2 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 EEA07096.1 - 0.041 14.3 0.0 0.083 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain DUF4059 PF13268.6 EEA07096.1 - 0.064 13.7 1.6 0.26 11.7 1.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4059) WD40 PF00400.32 EEA07097.1 - 0.0016 19.2 12.1 0.54 11.2 1.9 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat bZIP_1 PF00170.21 EEA07098.1 - 0.19 11.9 0.4 0.39 10.8 0.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor SKA1 PF07160.12 EEA07098.1 - 0.65 9.8 4.1 0.18 11.6 0.9 1.6 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 ATP_sub_h PF10775.9 EEA07099.1 - 0.05 13.6 0.6 0.41 10.7 0.0 2.6 2 0 0 2 2 2 0 ATP synthase complex subunit h Trimer_CC PF08954.11 EEA07099.1 - 0.081 12.5 0.2 0.21 11.2 0.2 1.7 1 0 0 1 1 1 0 Trimerisation motif Fe_hyd_lg_C PF02906.14 EEA07100.1 - 1e-40 140.0 0.8 3.6e-40 138.1 0.8 1.9 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain RNA_pol_Rpb4 PF03874.16 EEA07100.1 - 0.033 14.5 1.4 0.84 10.0 0.5 2.6 2 1 0 2 2 2 0 RNA polymerase Rpb4 AKAP95 PF04988.12 EEA07100.1 - 0.034 14.4 1.0 0.079 13.2 1.0 1.5 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Arf PF00025.21 EEA07101.1 - 5.6e-69 231.1 0.2 6.4e-69 230.9 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EEA07101.1 - 1e-11 44.7 0.0 1.3e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07101.1 - 1.3e-11 44.7 0.0 1.9e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EEA07101.1 - 8e-10 38.4 0.3 7.2e-05 22.1 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EEA07101.1 - 4.2e-07 30.0 0.0 6.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EEA07101.1 - 1.5e-06 27.8 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EEA07101.1 - 1.7e-06 27.6 0.0 2.4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EEA07101.1 - 0.0047 16.5 0.2 0.22 11.1 0.2 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 EEA07101.1 - 0.0058 15.6 0.1 0.042 12.8 0.0 1.9 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EEA07101.1 - 0.0082 15.7 0.0 0.057 12.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EEA07101.1 - 0.072 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RsgA_GTPase PF03193.16 EEA07101.1 - 0.08 12.8 0.0 0.68 9.8 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase TB2_DP1_HVA22 PF03134.19 EEA07102.1 - 0.32 11.0 4.5 0.083 12.8 0.8 1.9 1 1 1 2 2 2 0 TB2/DP1, HVA22 family VirB3 PF05101.13 EEA07102.1 - 2.1 8.6 8.4 0.22 11.8 3.3 1.8 1 1 1 2 2 2 0 Type IV secretory pathway, VirB3-like protein Peptidase_C13 PF01650.18 EEA07103.1 - 6.2e-35 121.0 0.1 9.4e-35 120.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase C13 family Glycos_transf_1 PF00534.20 EEA07104.1 - 8.6e-26 90.5 0.0 3.8e-24 85.1 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EEA07104.1 - 1.5e-12 48.1 0.0 4.9e-12 46.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EEA07104.1 - 0.00045 20.3 0.0 0.00073 19.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EEA07104.1 - 0.013 15.8 0.0 0.039 14.3 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 FBA_2 PF07735.17 EEA07105.1 - 0.062 13.4 0.5 0.062 13.4 0.5 2.8 3 0 0 3 3 3 0 F-box associated NDUF_C2 PF06374.11 EEA07105.1 - 0.13 12.5 0.1 0.34 11.1 0.1 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) DEAD PF00270.29 EEA07106.1 - 5.3e-41 140.3 0.0 2.4e-40 138.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA07106.1 - 3.1e-29 101.6 0.2 5.2e-27 94.4 0.0 3.5 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA07106.1 - 8.4e-09 35.6 0.0 3.1e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ABA_GPCR PF12430.8 EEA07107.1 - 0.008 16.0 0.1 0.016 15.0 0.1 1.5 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor Ac76 PF05814.11 EEA07107.1 - 0.043 13.8 2.7 0.42 10.7 0.1 2.5 2 0 0 2 2 2 0 Orf76 (Ac76) Shisa PF13908.6 EEA07107.1 - 0.17 12.2 0.5 0.36 11.0 0.5 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator zf-C2H2_4 PF13894.6 EEA07108.1 - 1.1e-06 28.9 5.5 0.014 16.2 0.5 2.7 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EEA07108.1 - 3.2e-05 24.1 7.4 0.0007 19.8 1.4 3.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EEA07108.1 - 0.00017 21.8 7.9 0.077 13.5 0.7 2.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EEA07108.1 - 0.012 15.9 4.7 1.7 9.0 0.4 2.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 EEA07108.1 - 0.014 15.3 5.1 0.07 13.1 0.1 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 EEA07108.1 - 0.05 13.9 4.5 0.46 10.8 0.5 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3960 PF13142.6 EEA07108.1 - 0.069 13.3 0.0 25 5.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3960) LIM PF00412.22 EEA07108.1 - 0.095 12.9 2.6 0.17 12.2 2.6 1.4 1 0 0 1 1 1 0 LIM domain zf-C2H2_6 PF13912.6 EEA07108.1 - 0.15 12.1 2.5 0.44 10.6 0.6 2.2 1 1 1 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.15 EEA07108.1 - 0.44 10.6 7.3 10 6.2 4.3 2.4 1 1 1 2 2 2 0 BED zinc finger PyrI_C PF02748.15 EEA07108.1 - 0.9 9.5 6.0 5.4 7.0 1.0 2.6 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain adh_short PF00106.25 EEA07109.1 - 3.9e-26 91.7 0.0 4.6e-25 88.2 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA07109.1 - 5.5e-12 45.7 0.0 9.8e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA07109.1 - 0.0017 18.3 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 KR domain UCH PF00443.29 EEA07110.1 - 1.8e-38 132.6 0.4 2.2e-38 132.2 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EEA07110.1 - 6.1e-09 35.5 0.0 2e-08 33.8 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin family UCH_1 PF13423.6 EEA07110.1 - 3.2e-06 27.0 2.9 1.9e-05 24.4 2.9 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_2 PF14560.6 EEA07110.1 - 0.00018 21.9 0.0 0.00096 19.6 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-like domain Ribosomal_S21e PF01249.18 EEA07111.1 - 1.6e-35 121.1 0.1 1.8e-35 120.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro2_C5 PF18565.1 EEA07111.1 - 0.029 14.2 0.1 0.035 14.0 0.1 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 CdiA_C PF18451.1 EEA07111.1 - 0.13 12.5 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Contact-dependent growth inhibition CdiA C-terminal domain AP_endonuc_2 PF01261.24 EEA07112.1 - 1.2e-28 100.0 0.0 1.8e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Sdh5 PF03937.16 EEA07113.1 - 6.8e-17 61.2 0.6 9.4e-17 60.7 0.6 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase PYRIN PF02758.16 EEA07113.1 - 0.086 13.0 1.0 0.56 10.4 0.2 2.1 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Oxysterol_BP PF01237.18 EEA07114.1 - 1.6e-111 372.7 0.2 2.2e-111 372.3 0.2 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein AAA PF00004.29 EEA07115.1 - 7.1e-93 308.0 0.0 5.7e-46 156.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA07115.1 - 1.9e-26 91.6 13.6 2e-15 56.3 1.1 3.1 3 1 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 EEA07115.1 - 7.7e-22 77.3 0.5 2e-21 75.9 0.5 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EEA07115.1 - 1.8e-13 50.5 0.0 8.4e-06 25.6 0.0 3.1 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA07115.1 - 1.3e-12 48.4 0.5 0.00022 21.6 0.0 4.2 2 2 1 3 3 3 2 AAA ATPase domain CDC48_2 PF02933.17 EEA07115.1 - 1.6e-11 43.8 0.0 3.9e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.14 EEA07115.1 - 5.2e-11 43.0 0.0 8e-06 26.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EEA07115.1 - 1.2e-10 41.5 0.1 1.1e-05 25.5 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EEA07115.1 - 2.9e-10 40.5 0.0 5.2e-05 23.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EEA07115.1 - 2.1e-08 34.5 1.3 0.031 14.5 0.0 4.5 3 2 0 4 4 4 2 AAA domain TIP49 PF06068.13 EEA07115.1 - 6e-08 32.3 0.0 0.0016 17.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EEA07115.1 - 1.8e-07 31.7 0.0 0.023 15.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EEA07115.1 - 7.4e-07 28.8 0.2 0.036 13.5 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA07115.1 - 1.3e-06 28.7 0.0 0.027 14.8 0.0 3.1 3 0 0 3 3 2 2 RNA helicase AAA_14 PF13173.6 EEA07115.1 - 1.6e-06 28.2 0.0 0.018 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EEA07115.1 - 6.1e-06 26.1 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.6 EEA07115.1 - 6.9e-06 25.8 0.2 0.63 9.6 0.0 3.4 2 1 0 3 3 3 1 AAA domain NACHT PF05729.12 EEA07115.1 - 3.6e-05 23.7 0.0 0.52 10.2 0.0 3.4 3 1 0 4 4 3 2 NACHT domain ATPase_2 PF01637.18 EEA07115.1 - 3.8e-05 23.7 0.0 0.61 9.9 0.0 3.2 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 EEA07115.1 - 5e-05 23.3 0.0 0.022 14.6 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_28 PF13521.6 EEA07115.1 - 6.5e-05 23.2 0.0 0.37 11.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EEA07115.1 - 9.9e-05 22.1 0.0 0.15 11.8 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 EEA07115.1 - 0.0001 21.9 0.0 0.35 10.3 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region ATPase PF06745.13 EEA07115.1 - 0.0001 21.8 0.1 2.3 7.5 0.0 3.4 3 0 0 3 3 3 1 KaiC ABC_tran PF00005.27 EEA07115.1 - 0.00011 22.7 0.0 0.37 11.3 0.0 2.8 2 1 0 2 2 2 2 ABC transporter TsaE PF02367.17 EEA07115.1 - 0.00012 22.1 0.0 0.65 10.0 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 EEA07115.1 - 0.00012 22.5 0.1 0.32 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EEA07115.1 - 0.00019 21.2 0.1 0.26 11.0 0.0 2.6 2 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EEA07115.1 - 0.00021 21.1 0.0 0.029 14.1 0.0 2.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Parvo_NS1 PF01057.17 EEA07115.1 - 0.00028 20.1 0.0 0.46 9.5 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 EEA07115.1 - 0.00051 19.3 0.0 0.89 8.7 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain Vps4_C PF09336.10 EEA07115.1 - 0.00065 19.6 0.1 0.0045 16.9 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Zeta_toxin PF06414.12 EEA07115.1 - 0.0008 18.7 0.0 0.74 9.1 0.0 2.9 3 0 0 3 3 2 1 Zeta toxin Sigma54_activ_2 PF14532.6 EEA07115.1 - 0.0017 18.5 0.0 0.38 10.9 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain PhoH PF02562.16 EEA07115.1 - 0.0025 17.3 0.1 1.8 7.9 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 EEA07115.1 - 0.0031 16.7 0.0 0.6 9.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) DUF2075 PF09848.9 EEA07115.1 - 0.0036 16.6 0.0 0.71 9.0 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 EEA07115.1 - 0.0052 16.6 0.0 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EEA07115.1 - 0.0074 16.3 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Rad17 PF03215.15 EEA07115.1 - 0.0089 16.0 0.0 1.1 9.2 0.0 2.7 2 1 0 2 2 2 1 Rad17 P-loop domain NTPase_1 PF03266.15 EEA07115.1 - 0.015 15.2 0.2 7.8 6.4 0.0 3.5 3 0 0 3 3 3 0 NTPase AAA_19 PF13245.6 EEA07115.1 - 0.016 15.5 0.1 8.9 6.6 0.1 3.0 2 1 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EEA07115.1 - 0.025 14.3 0.1 7.7 6.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EEA07115.1 - 0.036 13.9 0.0 10 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EEA07115.1 - 0.047 13.8 0.1 17 5.5 0.0 2.8 3 0 0 3 3 2 0 Shikimate kinase AAA_29 PF13555.6 EEA07115.1 - 0.047 13.4 0.0 5.8 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain KAP_NTPase PF07693.14 EEA07115.1 - 0.047 12.9 0.1 1.4 8.1 0.0 3.0 2 2 1 4 4 4 0 KAP family P-loop domain Cytidylate_kin PF02224.18 EEA07115.1 - 0.05 13.3 0.1 7.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase Cytidylate_kin2 PF13189.6 EEA07115.1 - 0.05 13.7 0.0 11 6.1 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family Josephin PF02099.17 EEA07116.1 - 1.2e-37 129.6 0.0 2.4e-37 128.5 0.0 1.5 1 0 0 1 1 1 1 Josephin UBX PF00789.20 EEA07116.1 - 2e-05 24.7 0.0 4.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain G10 PF01125.17 EEA07116.1 - 0.1 12.4 0.0 0.41 10.4 0.0 2.0 2 0 0 2 2 2 0 G10 protein RRM_1 PF00076.22 EEA07117.1 - 1.6e-10 40.6 0.0 0.027 14.3 0.1 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Noc2 PF03715.13 EEA07118.1 - 5.4e-35 121.1 12.5 1.4e-34 119.7 12.5 1.7 1 0 0 1 1 1 1 Noc2p family DUF4606 PF15379.6 EEA07118.1 - 0.036 14.3 1.1 0.15 12.3 1.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) Peptidase_M14 PF00246.24 EEA07119.1 - 9.8e-40 137.2 0.0 1.4e-39 136.6 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Coq4 PF05019.13 EEA07120.1 - 2.1e-51 174.4 0.1 7.2e-47 159.6 0.0 2.0 2 0 0 2 2 2 2 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Apolipoprotein PF01442.18 EEA07121.1 - 0.00017 21.5 13.4 0.031 14.1 3.0 2.3 2 0 0 2 2 2 2 Apolipoprotein A1/A4/E domain OmpH PF03938.14 EEA07121.1 - 0.00038 20.8 9.2 0.00038 20.8 9.2 2.6 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) ING PF12998.7 EEA07121.1 - 0.0098 16.5 23.7 0.061 13.9 4.4 3.4 1 1 3 4 4 4 2 Inhibitor of growth proteins N-terminal histone-binding PBC PF03792.13 EEA07121.1 - 0.021 14.6 18.0 0.02 14.7 7.6 3.7 1 1 2 3 3 3 0 PBC domain FAM184 PF15665.5 EEA07121.1 - 0.23 11.2 22.2 4.4 7.0 18.9 2.2 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B T7SS_ESX_EspC PF10824.8 EEA07121.1 - 0.26 11.8 2.0 1.6 9.3 0.1 2.9 2 2 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm Bap31_Bap29_C PF18035.1 EEA07121.1 - 1.6 8.8 9.5 4.5 7.3 1.0 3.4 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Phage_Mu_Gam PF07352.12 EEA07121.1 - 2.9 7.8 24.6 0.15 12.0 4.3 3.4 1 1 1 3 3 3 0 Bacteriophage Mu Gam like protein Vir_act_alpha_C PF10400.9 EEA07121.1 - 3.6 8.4 10.2 4.9 7.9 0.7 3.3 2 2 1 3 3 3 0 Virulence activator alpha C-term Baculo_PEP_C PF04513.12 EEA07121.1 - 4.8 7.2 19.2 0.32 11.0 9.3 2.6 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LZ3wCH PF18517.1 EEA07121.1 - 9.5 6.4 13.6 2 8.6 0.2 4.2 3 2 1 4 4 4 0 Leucine zipper with capping helix domain Pkinase PF00069.25 EEA07122.1 - 6e-24 84.8 5.5 1.3e-23 83.7 1.0 3.3 2 2 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07122.1 - 3.5e-05 23.2 0.3 0.0037 16.6 0.0 2.9 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA07122.1 - 0.079 11.7 0.2 0.13 11.0 0.2 1.3 1 0 0 1 1 1 0 Fungal protein kinase UQ_con PF00179.26 EEA07123.1 - 1.2e-45 154.6 0.0 1.4e-45 154.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA07123.1 - 0.0065 16.2 0.0 0.021 14.5 0.0 1.7 1 1 1 2 2 2 1 Prokaryotic E2 family B Proteasome PF00227.26 EEA07124.1 - 5.4e-31 107.6 0.0 6.9e-31 107.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit EMP24_GP25L PF01105.24 EEA07125.1 - 1.6e-25 90.1 1.1 4.4e-25 88.7 1.1 1.6 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Melibiase_C PF17801.1 EEA07125.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Alpha galactosidase C-terminal beta sandwich domain ASFV_J13L PF05568.11 EEA07125.1 - 2.7 7.7 4.7 1.5 8.5 1.5 1.9 2 0 0 2 2 2 0 African swine fever virus J13L protein Peptidase_S24 PF00717.23 EEA07126.1 - 2.4e-11 43.4 0.2 3.4e-11 42.9 0.2 1.3 1 0 0 1 1 1 1 Peptidase S24-like DNA_ligase_OB PF03120.16 EEA07126.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent DNA ligase OB-fold domain V-SNARE_C PF12352.8 EEA07127.1 - 0.025 14.9 1.0 0.056 13.7 1.0 1.6 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EEA07127.1 - 0.047 13.6 5.8 0.09 12.7 4.5 2.2 1 1 0 1 1 1 0 Sec20 LMBR1 PF04791.16 EEA07127.1 - 2.3 7.0 12.3 3.3 6.5 12.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 EEA07128.1 - 2.6e-14 53.4 9.7 8.1e-07 29.7 0.1 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Sec34 PF04136.15 EEA07128.1 - 0.0071 16.2 0.5 0.012 15.5 0.5 1.3 1 0 0 1 1 1 1 Sec34-like family ANAPC4_WD40 PF12894.7 EEA07128.1 - 0.0082 16.4 0.0 0.07 13.4 0.0 2.6 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF5311 PF17238.2 EEA07128.1 - 0.033 14.1 0.1 0.057 13.3 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5311) ELYS-bb PF16687.5 EEA07128.1 - 0.076 11.6 0.0 0.16 10.5 0.0 1.5 1 1 0 1 1 1 0 beta-propeller of ELYS nucleoporin BPL_LplA_LipB PF03099.19 EEA07129.1 - 7.9e-06 25.8 0.8 1.7e-05 24.7 0.8 1.7 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EEA07129.1 - 0.012 15.5 0.3 0.022 14.6 0.3 1.4 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain DUF262 PF03235.14 EEA07129.1 - 0.015 15.5 2.3 0.015 15.5 2.3 1.5 1 1 1 2 2 2 0 Protein of unknown function DUF262 UPF0669 PF17065.5 EEA07130.1 - 0.019 14.7 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 WD40 PF00400.32 EEA07131.1 - 1.1e-13 51.4 2.8 0.00042 21.0 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07131.1 - 2.7e-09 37.2 0.0 0.00012 22.3 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain HPS3_N PF14761.6 EEA07131.1 - 0.00067 19.3 0.0 0.018 14.6 0.0 2.2 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3 PD40 PF07676.12 EEA07131.1 - 0.016 15.1 0.1 8.4 6.5 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Homeodomain PF00046.29 EEA07133.1 - 0.0057 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain DUF737 PF05300.11 EEA07134.1 - 0.24 11.7 50.3 0.021 15.2 4.0 4.6 3 1 1 4 4 4 0 Protein of unknown function (DUF737) Ras PF00071.22 EEA07135.1 - 1.5e-60 203.5 0.1 1.8e-60 203.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07135.1 - 5.7e-37 126.6 0.0 6.4e-36 123.2 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA07135.1 - 2.6e-16 59.6 0.0 3.6e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA07135.1 - 0.0027 17.8 0.0 0.004 17.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA07135.1 - 0.0031 17.1 0.0 0.012 15.1 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EEA07135.1 - 0.0035 16.7 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EEA07135.1 - 0.019 14.9 0.0 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase MuF_C PF18819.1 EEA07135.1 - 0.061 13.3 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Phage MuF-C-terminal domain TniB PF05621.11 EEA07135.1 - 0.18 11.2 0.0 0.41 10.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Orai-1 PF07856.12 EEA07136.1 - 0.61 9.8 6.6 2.9 7.5 1.4 2.2 1 1 1 2 2 2 0 Mediator of CRAC channel activity AAA PF00004.29 EEA07137.1 - 4.2e-13 49.9 0.0 1.1e-12 48.5 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EEA07137.1 - 4.7e-13 49.3 0.0 3.1e-12 46.7 0.0 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EEA07137.1 - 1.1e-12 48.1 0.1 5.3e-12 45.8 0.1 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EEA07137.1 - 9.3e-12 45.2 0.1 2.2e-11 44.0 0.0 1.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_19 PF13245.6 EEA07137.1 - 1.5e-06 28.6 0.0 2.9e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA07137.1 - 2.3e-06 27.4 0.0 3.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EEA07137.1 - 5.1e-06 26.8 0.0 1.1e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EEA07137.1 - 0.00013 22.0 0.1 0.00097 19.1 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EEA07137.1 - 0.00013 22.4 0.0 0.00034 21.0 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 EEA07137.1 - 0.00045 20.1 0.0 0.0011 18.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.13 EEA07137.1 - 0.00074 19.3 0.1 0.0022 17.8 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EEA07137.1 - 0.00077 19.8 0.0 0.0022 18.3 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain AAA_14 PF13173.6 EEA07137.1 - 0.0022 18.0 0.0 0.0091 16.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EEA07137.1 - 0.0024 17.6 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain PIF1 PF05970.14 EEA07137.1 - 0.0024 17.1 0.1 0.0093 15.2 0.1 1.9 1 1 0 1 1 1 1 PIF1-like helicase AAA_7 PF12775.7 EEA07137.1 - 0.0032 17.0 0.0 0.0067 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 EEA07137.1 - 0.0052 16.5 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EEA07137.1 - 0.011 15.5 0.1 0.03 14.2 0.0 1.7 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EEA07137.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 EEA07137.1 - 0.016 15.8 0.0 0.042 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EEA07137.1 - 0.019 15.5 0.1 0.031 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EEA07137.1 - 0.038 13.4 0.1 0.087 12.2 0.0 1.6 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA07137.1 - 0.041 14.3 0.2 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase DEAD PF00270.29 EEA07137.1 - 0.059 13.1 0.2 0.39 10.5 0.2 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_28 PF13521.6 EEA07137.1 - 0.064 13.5 0.0 0.15 12.3 0.0 1.7 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 EEA07137.1 - 0.068 13.7 0.1 3.4 8.2 0.0 2.5 1 1 0 2 2 2 0 ABC transporter ResIII PF04851.15 EEA07137.1 - 0.13 12.3 0.1 0.47 10.4 0.1 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA07137.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Phage_holin_6_1 PF09682.10 EEA07137.1 - 0.18 12.2 0.7 10 6.6 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) FtsK_SpoIIIE PF01580.18 EEA07137.1 - 0.24 10.7 0.6 0.72 9.2 0.1 2.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family Pkinase PF00069.25 EEA07138.1 - 2.2e-11 43.7 1.2 7.6e-11 41.9 0.1 2.5 2 1 0 2 2 2 1 Protein kinase domain Bromodomain PF00439.25 EEA07139.1 - 1.1e-19 70.3 1.0 3.1e-19 68.8 1.0 1.8 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EEA07139.1 - 1.9e-12 47.5 0.1 3.9e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA07139.1 - 9e-08 32.1 0.0 1.7e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA07139.1 - 9.5e-07 29.2 0.9 1.9e-06 28.2 0.9 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA07139.1 - 0.00088 19.2 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA07139.1 - 0.0056 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain UPF0203 PF05254.12 EEA07139.1 - 0.1 12.8 1.6 19 5.6 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) DeoC PF01791.9 EEA07140.1 - 0.0031 17.2 0.2 0.01 15.4 0.4 1.8 2 1 0 2 2 2 1 DeoC/LacD family aldolase LNS2 PF08235.13 EEA07141.1 - 6.1e-94 313.7 0.0 8.6e-94 313.2 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EEA07141.1 - 2.9e-34 117.1 0.0 5.3e-34 116.2 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 EEA07141.1 - 4e-13 49.4 0.1 1.1e-12 48.0 0.0 1.7 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Acid_phosphat_B PF03767.14 EEA07141.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_6 PF13344.6 EEA07141.1 - 0.05 13.7 0.0 1.2 9.2 0.0 2.7 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase ARPC4 PF05856.12 EEA07142.1 - 8.5e-54 181.6 1.4 8.5e-54 181.6 1.4 1.8 2 0 0 2 2 2 1 ARP2/3 complex 20 kDa subunit (ARPC4) Pkinase PF00069.25 EEA07143.1 - 1.1e-50 172.5 0.0 1e-35 123.4 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07143.1 - 1.6e-23 83.3 0.0 3e-15 56.2 0.0 3.7 2 1 0 2 2 2 2 Protein tyrosine kinase RWD PF05773.22 EEA07143.1 - 0.011 16.0 1.9 0.021 15.1 0.1 2.3 2 0 0 2 2 2 0 RWD domain tRNA-synt_2 PF00152.20 EEA07143.1 - 0.098 11.7 0.0 0.29 10.2 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Peptidase_M54 PF07998.11 EEA07144.1 - 1.9e-15 57.4 0.4 3.8e-15 56.4 0.3 1.3 1 1 0 1 1 1 1 Peptidase family M54 Peptidase_M10 PF00413.24 EEA07144.1 - 0.013 15.3 0.1 0.022 14.6 0.0 1.4 1 1 0 1 1 1 0 Matrixin Endopep_inhib PF16800.5 EEA07144.1 - 0.067 13.1 0.5 0.11 12.4 0.5 1.3 1 0 0 1 1 1 0 IseA DL-endopeptidase inhibitor CBF PF03914.17 EEA07145.1 - 6.2e-14 52.4 0.7 1.3e-13 51.4 0.7 1.6 1 0 0 1 1 1 1 CBF/Mak21 family AAA_18 PF13238.6 EEA07146.1 - 8.2e-29 100.8 0.1 1.1e-28 100.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA07146.1 - 1.5e-05 25.1 0.0 5.2e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EEA07146.1 - 2e-05 25.0 0.1 4.8e-05 23.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EEA07146.1 - 0.00015 21.8 0.0 0.00018 21.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EEA07146.1 - 0.00018 21.9 0.8 0.00041 20.8 0.8 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EEA07146.1 - 0.00027 21.2 0.0 0.00035 20.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EEA07146.1 - 0.00028 20.4 0.0 0.00044 19.8 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 dNK PF01712.19 EEA07146.1 - 0.0013 18.6 3.1 0.25 11.2 0.2 2.2 1 1 1 2 2 2 2 Deoxynucleoside kinase AAA_22 PF13401.6 EEA07146.1 - 0.0014 18.9 0.4 0.0033 17.7 0.3 1.8 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EEA07146.1 - 0.012 15.3 0.2 0.13 12.0 0.1 2.3 1 1 1 2 2 2 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 EEA07146.1 - 0.013 15.3 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EEA07146.1 - 0.018 15.5 0.4 0.04 14.3 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EEA07146.1 - 0.021 14.1 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EEA07146.1 - 0.026 14.8 0.4 0.041 14.2 0.4 1.4 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EEA07146.1 - 0.031 13.4 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 EEA07146.1 - 0.037 13.7 1.9 0.06 13.1 0.8 1.8 1 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EEA07146.1 - 0.042 13.9 0.1 0.085 12.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA07146.1 - 0.043 13.7 1.0 0.068 13.1 0.3 1.7 2 0 0 2 2 2 0 NTPase RNA_helicase PF00910.22 EEA07146.1 - 0.044 14.2 1.3 0.11 12.9 0.2 2.1 2 2 0 2 2 2 0 RNA helicase GvpD PF07088.11 EEA07146.1 - 0.065 11.9 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 GvpD gas vesicle protein Mg_chelatase PF01078.21 EEA07146.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF4325 PF14213.6 EEA07146.1 - 0.12 12.1 2.9 0.12 12.0 0.1 2.6 3 1 0 3 3 3 0 STAS-like domain of unknown function (DUF4325) Ninjurin PF04923.12 EEA07148.1 - 0.0095 15.9 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Ninjurin DUF3981 PF13139.6 EEA07148.1 - 0.11 12.9 3.4 0.17 12.3 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3981) Sigma_reg_N PF13800.6 EEA07148.1 - 3.5 8.0 5.7 0.79 10.1 0.1 2.3 2 1 0 2 2 2 0 Sigma factor regulator N-terminal Med31 PF05669.12 EEA07149.1 - 7.4e-36 122.1 2.6 8.7e-36 121.8 2.6 1.0 1 0 0 1 1 1 1 SOH1 L27_2 PF09045.10 EEA07149.1 - 0.023 14.6 0.3 0.048 13.6 0.3 1.5 1 0 0 1 1 1 0 L27_2 UPF0242 PF06785.11 EEA07150.1 - 0.0019 18.3 19.2 0.0019 18.3 19.2 3.5 2 2 1 3 3 3 2 Uncharacterised protein family (UPF0242) N-terminus PRKG1_interact PF15898.5 EEA07150.1 - 0.0077 17.1 10.1 0.0077 17.1 10.1 4.9 3 1 2 5 5 5 1 cGMP-dependent protein kinase interacting domain DUF3450 PF11932.8 EEA07150.1 - 1.1 8.5 20.5 0.87 8.8 11.5 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 EEA07150.1 - 1.5 7.7 31.3 0.018 13.9 18.5 3.1 2 1 1 3 3 3 0 Spc7 kinetochore protein SKA2 PF16740.5 EEA07150.1 - 1.6 8.5 18.2 0.71 9.7 8.2 3.2 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF745 PF05335.13 EEA07150.1 - 1.7 8.3 12.4 5.6 6.6 10.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF745) FUSC PF04632.12 EEA07150.1 - 1.8 7.0 2.2 2.5 6.5 2.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family tRNA-synt_2d PF01409.20 EEA07151.1 - 2.3e-80 269.6 0.0 3.1e-80 269.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 EEA07151.1 - 9.3e-12 44.5 0.0 1.6e-10 40.5 0.0 2.4 2 0 0 2 2 2 1 PheRS DNA binding domain 1 tRNA_synthFbeta PF17759.1 EEA07151.1 - 0.00046 19.7 0.0 0.0014 18.1 0.0 1.7 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD3 PF18553.1 EEA07151.1 - 0.00046 20.4 0.0 0.0033 17.7 0.0 2.3 2 0 0 2 2 2 1 PheRS DNA binding domain 3 S10_plectin PF03501.15 EEA07151.1 - 0.0011 19.0 0.0 0.0034 17.4 0.0 1.8 1 0 0 1 1 1 1 Plectin/S10 domain tRNA-synt_2 PF00152.20 EEA07151.1 - 0.0068 15.5 0.0 0.045 12.8 0.1 2.0 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) HTH_45 PF14947.6 EEA07151.1 - 0.18 11.8 3.0 8 6.5 0.5 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix Ribosomal_L7Ae PF01248.26 EEA07153.1 - 5.8e-08 32.4 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Diphthamide_syn PF01866.17 EEA07155.1 - 4.4e-19 69.0 10.3 2.9e-09 36.8 0.1 2.9 2 1 0 2 2 2 2 Putative diphthamide synthesis protein AOX PF01786.17 EEA07157.1 - 2.2e-85 285.6 0.1 2.7e-85 285.3 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase ANAPC10 PF03256.16 EEA07157.1 - 0.13 11.9 0.3 18 4.9 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, subunit 10 (APC10) Ssl1 PF04056.14 EEA07158.1 - 7e-35 120.6 0.1 9.5e-35 120.2 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 EEA07158.1 - 1.1e-09 38.9 0.0 1.9e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EEA07158.1 - 0.067 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain Tfb4 PF03850.14 EEA07158.1 - 0.18 11.3 11.1 0.94 8.9 8.6 2.5 2 1 0 2 2 2 0 Transcription factor Tfb4 MFS_1 PF07690.16 EEA07159.1 - 3.5e-37 128.2 31.5 1.8e-29 102.8 14.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EEA07159.1 - 4.2e-11 42.4 2.0 4.2e-11 42.4 2.0 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EEA07159.1 - 5.6e-08 31.5 0.8 8.4e-05 21.1 0.0 2.8 1 1 2 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EEA07159.1 - 1.1e-07 31.1 7.1 6.6e-07 28.5 6.4 2.4 1 1 1 2 2 2 2 MFS_1 like family WD40 PF00400.32 EEA07161.1 - 5.1e-13 49.3 10.9 6.6e-05 23.6 0.2 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat LisH_TPL PF17814.1 EEA07161.1 - 6.1e-10 38.6 0.3 1.5e-09 37.4 0.3 1.7 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 EEA07161.1 - 1.2e-09 38.4 0.0 0.017 15.4 0.0 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA07161.1 - 0.00041 20.3 0.5 0.0018 18.2 0.1 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A SLH PF00395.20 EEA07161.1 - 0.063 13.3 0.3 0.28 11.2 0.1 2.1 2 0 0 2 2 2 0 S-layer homology domain CRM1_C PF08767.11 EEA07163.1 - 3.3e-80 269.6 16.7 3.3e-80 269.6 16.7 4.0 4 0 0 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 EEA07163.1 - 9e-28 97.2 5.4 9e-28 97.2 5.4 4.8 7 0 0 7 7 7 1 Exportin 1-like protein CRM1_repeat_3 PF18787.1 EEA07163.1 - 6e-22 77.5 3.3 7.3e-22 77.2 0.6 2.7 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat_2 PF18784.1 EEA07163.1 - 1.1e-19 69.8 0.2 3.7e-19 68.1 0.2 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat PF18777.1 EEA07163.1 - 5.6e-10 38.6 0.2 2e-09 36.8 0.2 2.0 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EEA07163.1 - 9.8e-08 31.8 0.4 9.8e-08 31.8 0.4 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Pkinase PF00069.25 EEA07165.1 - 8.3e-71 238.4 0.0 1.1e-70 238.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07165.1 - 2.6e-36 125.2 0.0 3.5e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA07165.1 - 1.8e-06 27.5 0.2 1.6e-05 24.4 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EEA07165.1 - 0.034 13.2 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.9 EEA07165.1 - 0.053 13.0 0.0 0.094 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Lact-deh-memb PF09330.11 EEA07165.1 - 0.058 12.7 0.1 0.08 12.3 0.1 1.2 1 0 0 1 1 1 0 D-lactate dehydrogenase, membrane binding Pkinase_fungal PF17667.1 EEA07165.1 - 0.086 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EEA07165.1 - 0.097 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EEA07166.1 - 5.3e-69 232.5 0.0 7.3e-69 232.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07166.1 - 6.1e-34 117.5 0.0 9.8e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA07166.1 - 8.2e-05 22.0 0.1 0.00031 20.2 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EEA07166.1 - 0.0052 15.8 0.2 0.011 14.8 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EEA07166.1 - 0.12 12.0 0.1 0.29 10.7 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 IF-2B PF01008.17 EEA07167.1 - 2.7e-41 141.6 1.5 3.5e-41 141.3 1.5 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family L_lactis_RepB_C PF06430.12 EEA07167.1 - 0.014 15.4 0.0 0.043 13.8 0.0 1.8 1 0 0 1 1 1 0 Lactococcus lactis RepB C-terminus Xrn1_D3 PF18194.1 EEA07167.1 - 0.059 13.5 0.5 2.4 8.3 0.2 2.4 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 ArAE_1_C PF11728.8 EEA07167.1 - 0.11 12.5 0.2 0.22 11.5 0.2 1.5 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain Fungal_KA1 PF16797.5 EEA07168.1 - 0.016 14.9 0.1 0.1 12.3 0.1 2.4 1 0 0 1 1 1 0 Fungal kinase associated-1 domain PC_rep PF01851.22 EEA07168.1 - 0.041 14.3 0.1 0.26 11.8 0.1 2.6 2 0 0 2 2 2 0 Proteasome/cyclosome repeat DUF2428 PF10350.9 EEA07168.1 - 0.06 12.6 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) Cullin_binding PF03556.15 EEA07168.1 - 8.1 6.9 7.7 4.5 7.7 0.0 4.2 4 0 0 4 4 4 0 Cullin binding RabGAP-TBC PF00566.18 EEA07169.1 - 5e-21 75.3 17.7 1.6e-14 54.1 3.0 3.1 3 1 0 3 3 3 2 Rab-GTPase-TBC domain zinc_ribbon_16 PF17034.5 EEA07171.1 - 4.6e-14 52.7 12.1 2.1e-13 50.6 12.1 2.2 1 0 0 1 1 1 1 Zinc-ribbon like family AP2 PF00847.20 EEA07172.1 - 6.7e-07 29.4 0.4 0.049 13.9 0.0 3.6 3 0 0 3 3 3 2 AP2 domain CLAMP PF14769.6 EEA07172.1 - 0.86 10.1 4.6 0.54 10.7 0.2 2.9 3 0 0 3 3 3 0 Flagellar C1a complex subunit C1a-32 KH_8 PF17903.1 EEA07175.1 - 1.5e-31 108.3 4.2 2.3e-31 107.7 0.0 3.1 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 EEA07175.1 - 0.00055 19.7 0.0 0.0018 18.1 0.0 1.9 1 0 0 1 1 1 1 KH domain PLDc_2 PF13091.6 EEA07176.1 - 1.4e-29 102.7 0.2 2e-14 53.6 0.1 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EEA07176.1 - 7.3e-06 25.9 0.8 0.082 13.1 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif Tim44 PF04280.15 EEA07177.1 - 2.2e-27 96.0 0.0 2.5e-26 92.5 0.0 2.4 1 1 0 1 1 1 1 Tim44-like domain Peptidase_C54 PF03416.19 EEA07178.1 - 6e-58 196.4 2.0 7.4e-58 196.1 2.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EEA07178.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C78 Pkinase_Tyr PF07714.17 EEA07180.1 - 9.1e-45 153.0 0.0 3.8e-44 150.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EEA07180.1 - 1.7e-42 145.6 0.0 4.3e-42 144.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EEA07180.1 - 0.00038 19.4 0.0 0.00072 18.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase PROCN PF08083.11 EEA07181.1 - 1.2e-226 752.1 10.7 2e-226 751.4 10.7 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EEA07181.1 - 1.9e-122 407.3 0.3 3.8e-122 406.2 0.3 1.6 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EEA07181.1 - 1.6e-88 294.6 2.2 4e-88 293.4 2.2 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EEA07181.1 - 9.2e-84 278.9 2.6 2.5e-83 277.5 2.6 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EEA07181.1 - 9.3e-69 229.7 0.0 1.9e-68 228.7 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EEA07181.1 - 3.8e-44 148.9 0.4 1.2e-43 147.4 0.4 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EEA07181.1 - 3.9e-39 133.4 0.0 1.1e-38 131.9 0.0 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain LRR_9 PF14580.6 EEA07182.1 - 5e-36 123.8 2.1 5e-36 123.8 2.1 1.9 1 1 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 EEA07182.1 - 2.2e-10 40.1 11.3 1.1e-09 37.9 4.1 3.7 2 2 1 3 3 3 1 Leucine rich repeat LRR_4 PF12799.7 EEA07182.1 - 6.4e-08 32.8 24.5 0.00011 22.5 1.7 5.3 4 1 3 7 7 7 2 Leucine Rich repeats (2 copies) Mob_Pre PF01076.19 EEA07182.1 - 0.04 13.7 0.7 0.063 13.1 0.7 1.3 1 0 0 1 1 1 0 Plasmid recombination enzyme DUF1492 PF07374.11 EEA07182.1 - 0.32 11.2 2.7 3.3 7.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) LRR_1 PF00560.33 EEA07182.1 - 4.1 8.3 16.2 21 6.2 0.7 5.5 5 1 0 5 5 5 0 Leucine Rich Repeat Thioredoxin_8 PF13905.6 EEA07183.1 - 0.0045 17.3 1.8 0.58 10.5 0.1 2.9 2 1 1 3 3 3 1 Thioredoxin-like Dynactin_p22 PF07426.11 EEA07183.1 - 0.0082 16.0 4.1 0.73 9.7 4.1 2.2 1 1 0 1 1 1 1 Dynactin subunit p22 DUF5600 PF18150.1 EEA07183.1 - 0.017 15.7 0.2 0.049 14.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5600) Mod_r PF07200.13 EEA07183.1 - 0.035 14.2 6.0 0.14 12.2 5.4 2.1 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Bap31_Bap29_C PF18035.1 EEA07183.1 - 0.14 12.2 7.0 0.36 10.9 0.5 2.5 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain AMP-binding PF00501.28 EEA07184.1 - 1.5e-21 76.5 0.0 2.3e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C2-set PF05790.15 EEA07184.1 - 0.074 13.3 0.2 0.26 11.5 0.2 1.9 1 0 0 1 1 1 0 Immunoglobulin C2-set domain DUF2748 PF10871.8 EEA07186.1 - 0.003 16.3 0.1 0.0044 15.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2748) DUF3245 PF11595.8 EEA07187.1 - 0.0026 18.2 5.9 0.0043 17.5 0.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3245) NUFIP1 PF10453.9 EEA07188.1 - 0.00081 19.2 0.6 0.0031 17.3 0.0 2.3 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2 PF00096.26 EEA07188.1 - 0.043 14.3 0.1 0.043 14.3 0.1 2.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type HEPN-like_int PF18867.1 EEA07188.1 - 0.091 12.6 3.4 0.063 13.1 1.2 1.8 2 0 0 2 2 2 0 HEPN-like integron domain zf-C2H2_4 PF13894.6 EEA07188.1 - 0.46 11.5 0.1 0.46 11.5 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Paf1 PF03985.13 EEA07189.1 - 1.6e-05 24.1 0.1 0.075 12.0 0.0 2.3 2 0 0 2 2 2 2 Paf1 POP1 PF06978.11 EEA07190.1 - 3.2e-37 128.5 18.8 3.2e-37 128.5 18.8 2.7 2 1 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EEA07190.1 - 8.3e-26 90.2 0.0 3.6e-25 88.1 0.0 2.2 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.11 EEA07190.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain XRN1_D1 PF18332.1 EEA07190.1 - 0.13 12.0 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Exoribonuclease Xrn1 D1 domain HSCB_C PF07743.13 EEA07191.1 - 8.7e-09 35.8 0.6 1.7e-08 34.8 0.6 1.5 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EEA07191.1 - 1e-05 25.5 0.0 2.6e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Mei5_like PF17021.5 EEA07191.1 - 0.011 15.8 2.3 0.016 15.2 1.0 2.0 2 0 0 2 2 2 0 Putative double-strand recombination repair-like zinc_ribbon_5 PF13719.6 EEA07191.1 - 0.22 11.3 1.4 0.75 9.6 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-met PF12874.7 EEA07192.1 - 0.0015 18.8 0.6 0.0026 18.1 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EEA07192.1 - 0.0063 16.8 2.7 0.011 16.0 2.7 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding Cullin PF00888.22 EEA07193.1 - 1.3e-89 301.5 24.9 1.3e-89 301.5 24.9 2.0 2 1 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EEA07193.1 - 7.6e-12 45.1 0.2 9.2e-11 41.6 0.0 2.8 2 0 0 2 2 2 1 Cullin protein neddylation domain TH1 PF04858.13 EEA07194.1 - 2.2e-13 49.7 0.5 2.1e-07 30.0 0.0 4.7 5 0 0 5 5 5 4 TH1 protein PA28_beta PF02252.18 EEA07194.1 - 0.0053 16.4 0.2 0.031 13.9 0.1 2.4 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit TF_Zn_Ribbon PF08271.12 EEA07195.1 - 1.7e-05 24.2 2.1 4.8e-05 22.8 2.1 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 EEA07195.1 - 0.16 11.9 6.2 14 5.7 4.7 2.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain A2L_zn_ribbon PF08792.10 EEA07195.1 - 0.51 10.1 8.5 1.5 8.6 8.5 1.9 1 0 0 1 1 1 0 A2L zinc ribbon domain zf-RRN7 PF11781.8 EEA07195.1 - 1.2 8.9 8.7 4.3 7.1 8.7 2.1 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Herpes_UL52 PF03121.15 EEA07196.1 - 3.2e-12 46.2 0.3 1.1e-11 44.5 0.3 2.0 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase Ank_5 PF13857.6 EEA07197.1 - 5e-06 26.7 0.0 2.1e-05 24.7 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA07197.1 - 0.002 18.7 0.1 0.0074 16.9 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) SHS2_FTSA PF02491.20 EEA07197.1 - 3 8.3 6.9 3.3 8.2 0.1 4.0 5 0 0 5 5 5 0 SHS2 domain inserted in FTSA TLD PF07534.16 EEA07198.1 - 9.4e-26 90.7 0.0 2.5e-25 89.3 0.0 1.8 1 1 0 1 1 1 1 TLD PhoLip_ATPase_C PF16212.5 EEA07199.1 - 3.8e-55 187.4 25.8 3.8e-55 187.4 25.8 2.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA07199.1 - 2.6e-22 78.3 2.9 2.6e-22 78.3 2.9 3.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EEA07199.1 - 4.9e-12 46.6 0.0 9.9e-05 22.7 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EEA07199.1 - 0.00021 21.1 1.0 0.00095 19.0 0.1 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA07199.1 - 0.00075 19.5 0.0 0.0033 17.5 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EEA07199.1 - 0.0029 17.1 0.0 0.0029 17.1 0.0 3.1 2 2 1 3 3 3 1 E1-E2 ATPase TP6A_N PF04406.14 EEA07200.1 - 4e-13 49.1 0.5 7.5e-13 48.3 0.5 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.10 EEA07200.1 - 7.6e-05 22.7 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) CENP-C_C PF11699.8 EEA07201.1 - 6e-05 23.2 0.0 0.0002 21.5 0.0 1.9 1 0 0 1 1 1 1 Mif2/CENP-C like TRAPP PF04051.16 EEA07202.1 - 1.2e-31 109.5 0.0 1.4e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DnaJ PF00226.31 EEA07203.1 - 1.8e-24 85.6 0.1 4.2e-24 84.5 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 EEA07203.1 - 2.6e-06 27.4 0.0 8.5e-06 25.7 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin UBN_AB PF14075.6 EEA07203.1 - 0.085 12.6 3.5 0.16 11.6 3.5 1.5 1 0 0 1 1 1 0 Ubinuclein conserved middle domain SPC22 PF04573.12 EEA07204.1 - 7.5e-43 146.0 0.2 8.6e-43 145.8 0.2 1.0 1 0 0 1 1 1 1 Signal peptidase subunit UQ_con PF00179.26 EEA07205.1 - 5.3e-49 165.5 0.0 6.2e-49 165.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA07205.1 - 0.00081 19.7 0.0 0.0016 18.7 0.0 1.5 1 0 0 1 1 1 1 RWD domain DAGK_acc PF00609.19 EEA07209.1 - 9.6e-37 126.8 0.3 4e-14 53.3 0.0 3.6 2 1 0 3 3 3 3 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EEA07209.1 - 3.6e-24 84.8 0.0 5.7e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EEA07209.1 - 4.7e-10 39.2 25.6 2.9e-06 27.1 3.2 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Myticin-prepro PF10690.9 EEA07209.1 - 2.7 8.3 5.6 7.9 6.8 5.6 1.7 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Zf_RING PF16744.5 EEA07209.1 - 4.8 7.4 13.9 9.3 6.5 2.9 2.7 2 0 0 2 2 2 0 KIAA1045 RING finger RNA_pol_Rpb1_5 PF04998.17 EEA07210.1 - 6.1e-100 334.0 0.1 1e-99 333.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EEA07210.1 - 5.6e-99 331.4 0.0 9.8e-99 330.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EEA07210.1 - 8.1e-74 247.4 0.0 1.7e-73 246.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EEA07210.1 - 1.8e-52 178.0 0.0 4e-52 176.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EEA07210.1 - 2.2e-46 157.2 1.6 2.2e-46 157.2 1.6 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 EEA07210.1 - 8.4e-44 149.3 0.0 2.3e-43 147.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EEA07210.1 - 1.7e-36 124.4 0.1 5.1e-36 122.9 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EEA07210.1 - 5e-20 70.7 321.9 0.0032 17.8 11.6 22.0 11 3 10 24 24 24 19 RNA polymerase Rpb1 C-terminal repeat Swi3 PF07962.12 EEA07211.1 - 5.2e-06 26.4 0.3 1.1e-05 25.3 0.1 1.8 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 Kinesin PF00225.23 EEA07213.1 - 1.1e-103 346.7 4.0 1.1e-103 346.7 4.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA07213.1 - 1.2e-52 177.8 0.2 1.2e-52 177.8 0.2 2.5 2 1 0 2 2 2 1 Microtubule binding Nbl1_Borealin_N PF10444.9 EEA07213.1 - 1.1 8.9 8.4 6.3 6.5 0.9 2.9 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal YabA PF06156.13 EEA07213.1 - 1.1 9.9 25.6 12 6.6 0.0 5.4 4 1 1 5 5 5 0 Initiation control protein YabA TSC22 PF01166.18 EEA07213.1 - 1.9 8.9 16.0 5.1 7.5 1.1 3.9 2 1 1 3 3 3 0 TSC-22/dip/bun family Gp-FAR-1 PF05823.12 EEA07213.1 - 2 8.7 12.2 7.4 6.9 1.9 2.6 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) GIT1_C PF12205.8 EEA07213.1 - 3.6 7.7 11.1 2.8 8.1 3.4 3.6 3 1 1 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF1664 PF07889.12 EEA07213.1 - 7 6.7 13.3 14 5.8 4.8 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) CorA PF01544.18 EEA07213.1 - 7.6 5.8 12.0 24 4.1 9.6 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein RRM_1 PF00076.22 EEA07214.1 - 3.6e-19 68.3 0.8 8.9e-12 44.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA07214.1 - 3.2e-07 30.0 0.0 0.0043 16.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA07214.1 - 9.1e-07 28.7 0.0 3.8e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif Flg_hook PF02120.16 EEA07214.1 - 0.09 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Methyltransf_16 PF10294.9 EEA07215.1 - 4.1e-14 52.7 0.3 5.5e-08 32.7 0.0 2.4 1 1 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 EEA07215.1 - 0.028 14.0 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FAM86 PF14904.6 EEA07215.1 - 0.028 14.5 0.1 0.083 13.0 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function PrmA PF06325.13 EEA07215.1 - 0.081 12.3 0.3 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) RabGAP-TBC PF00566.18 EEA07216.1 - 4.3e-52 176.9 3.4 4.3e-52 176.9 3.4 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain TFIIS_C PF01096.18 EEA07217.1 - 1e-13 50.9 7.0 1e-13 50.9 7.0 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) gp37_C PF12604.8 EEA07217.1 - 0.027 14.2 0.1 0.047 13.4 0.1 1.4 1 0 0 1 1 1 0 Tail fibre protein gp37 C terminal Zn_Tnp_IS1595 PF12760.7 EEA07217.1 - 0.11 12.5 14.2 0.14 12.2 1.0 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain RNA_pol_Rpb1_1 PF04997.12 EEA07217.1 - 0.13 11.6 7.9 0.62 9.4 1.9 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 1 TF_Zn_Ribbon PF08271.12 EEA07217.1 - 5.7 6.5 9.7 2.4 7.8 0.7 3.3 4 0 0 4 4 4 0 TFIIB zinc-binding PHD_4 PF16866.5 EEA07217.1 - 9.8 6.4 10.9 5.2 7.2 1.6 2.8 2 1 0 2 2 2 0 PHD-finger DUF2387 PF09526.10 EEA07217.1 - 9.8 6.4 13.7 1.8 8.8 3.0 3.2 2 1 1 3 3 3 0 Probable metal-binding protein (DUF2387) Histone PF00125.24 EEA07219.1 - 1.4e-51 174.3 1.3 1.5e-51 174.1 1.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EEA07219.1 - 0.00032 21.0 0.0 0.00047 20.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EEA07219.1 - 0.00033 20.7 0.1 0.00054 20.1 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EEA07219.1 - 0.00087 19.9 2.9 0.0011 19.6 2.9 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EEA07219.1 - 0.012 15.9 0.1 0.021 15.1 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EEA07219.1 - 0.034 14.2 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Proteasome PF00227.26 EEA07220.1 - 1.6e-47 161.4 0.6 2e-47 161.1 0.6 1.1 1 0 0 1 1 1 1 Proteasome subunit NUMOD4 PF07463.11 EEA07220.1 - 0.011 15.9 0.4 0.026 14.7 0.4 1.6 1 0 0 1 1 1 0 NUMOD4 motif Pr_beta_C PF12465.8 EEA07220.1 - 2.9 7.4 5.3 0.52 9.8 0.3 2.2 2 0 0 2 2 2 0 Proteasome beta subunits C terminal TPR_2 PF07719.17 EEA07221.1 - 4.8e-14 51.3 13.2 0.0038 17.2 0.0 6.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 EEA07221.1 - 1.7e-11 44.4 0.9 0.0063 17.0 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA07221.1 - 1.7e-09 37.0 15.8 0.0021 17.8 0.1 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA07221.1 - 1.7e-08 35.0 0.1 3.1e-06 27.7 0.0 3.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA07221.1 - 1.8e-07 31.4 3.2 0.33 11.3 0.0 4.9 5 1 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA07221.1 - 2e-07 31.1 14.4 0.017 15.3 1.1 5.1 3 1 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EEA07221.1 - 4.9e-07 29.7 4.3 0.0014 18.8 0.2 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA07221.1 - 1.2e-06 28.8 0.2 0.18 12.5 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA07221.1 - 1.2e-06 28.8 0.0 2.7 9.1 0.1 5.7 3 2 3 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EEA07221.1 - 5.8e-05 22.8 1.9 0.13 12.4 0.0 4.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EEA07221.1 - 0.0011 18.8 6.6 3.3 7.7 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA07221.1 - 0.0087 15.7 0.2 0.0087 15.7 0.2 3.9 4 0 0 4 4 4 1 TPR repeat TPR_9 PF13371.6 EEA07221.1 - 0.079 13.1 0.0 0.83 9.8 0.0 2.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA07221.1 - 0.13 12.5 21.5 5.5 7.5 0.1 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Myb_DNA-binding PF00249.31 EEA07222.1 - 9e-12 45.0 8.8 4.4e-11 42.8 1.0 4.3 4 1 0 4 4 4 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA07222.1 - 8.3e-10 38.8 1.0 8.3e-10 38.8 1.0 4.3 4 1 0 4 4 4 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EEA07222.1 - 0.05 13.8 0.0 0.05 13.8 0.0 2.9 5 0 0 5 5 5 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_5 PF13873.6 EEA07222.1 - 0.083 13.0 5.3 18 5.5 0.7 4.6 4 1 1 5 5 5 0 Myb/SANT-like DNA-binding domain NFACT-C PF11923.8 EEA07222.1 - 0.093 12.6 0.5 0.31 11.0 0.0 2.2 2 0 0 2 2 2 0 NFACT protein C-terminal domain PAXIP1_C PF15364.6 EEA07222.1 - 0.096 13.0 4.1 0.19 12.0 4.1 1.4 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein P-mevalo_kinase PF04275.14 EEA07222.1 - 0.14 12.1 2.2 0.3 11.1 1.5 1.9 2 0 0 2 2 2 0 Phosphomevalonate kinase Nup35_RRM_2 PF14605.6 EEA07223.1 - 1.3e-17 63.5 0.0 1.9e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Thioredoxin PF00085.20 EEA07224.1 - 0.00034 20.5 0.0 0.0012 18.8 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EEA07224.1 - 0.038 13.8 0.0 0.038 13.8 0.0 2.3 3 0 0 3 3 3 0 Thioredoxin MFS_1 PF07690.16 EEA07225.1 - 3.5e-09 36.1 15.1 4.5e-09 35.7 14.6 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1233 PF06806.12 EEA07227.1 - 0.085 12.5 0.0 0.42 10.3 0.0 2.0 2 0 0 2 2 2 0 Putative excisionase (DUF1233) eIF3_subunit PF08597.10 EEA07229.1 - 4.5e-06 26.8 6.9 8.1e-06 25.9 6.9 1.4 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit Glyco_transf_8 PF01501.20 EEA07229.1 - 0.071 12.7 2.9 0.34 10.4 0.4 2.0 1 1 1 2 2 2 0 Glycosyl transferase family 8 Phage_lysis PF03245.13 EEA07229.1 - 0.11 12.7 1.1 0.19 11.9 1.1 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein UbiA PF01040.18 EEA07230.1 - 3.4e-44 151.0 3.7 4.3e-44 150.7 3.7 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family GYF PF02213.16 EEA07231.1 - 5.4e-09 35.6 0.0 1.7e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 GYF domain IQ PF00612.27 EEA07231.1 - 0.034 13.9 0.4 0.08 12.8 0.4 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ribosomal_S13 PF00416.22 EEA07232.1 - 8.6e-53 178.1 4.6 1e-52 177.9 4.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 CorA PF01544.18 EEA07233.1 - 8.1e-06 25.4 0.9 1.6e-05 24.4 0.9 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein IES5 PF17335.2 EEA07233.1 - 0.0011 19.2 2.5 0.0036 17.5 2.5 1.8 1 0 0 1 1 1 1 Ino80 complex subunit 5 Ufd2P_core PF10408.9 EEA07234.1 - 5.5e-132 441.5 27.1 7.3e-132 441.1 27.1 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EEA07234.1 - 2.6e-23 82.0 2.0 2.6e-23 82.0 2.0 2.8 3 0 0 3 3 3 1 U-box domain Menin PF05053.13 EEA07234.1 - 0.12 10.7 0.7 0.19 10.0 0.7 1.2 1 0 0 1 1 1 0 Menin SMK-1 PF04802.15 EEA07236.1 - 6.8e-28 97.8 7.1 1.9e-27 96.4 7.1 1.8 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Ran_BP1 PF00638.18 EEA07236.1 - 0.094 13.0 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 RanBP1 domain SET PF00856.28 EEA07237.1 - 3.3e-20 73.2 0.2 1.8e-19 70.8 0.0 2.3 2 1 0 2 2 2 1 SET domain PHD PF00628.29 EEA07237.1 - 2.4e-06 27.3 7.4 2.4e-06 27.3 7.4 2.9 2 1 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EEA07237.1 - 0.0093 15.5 3.9 0.0093 15.5 3.9 2.3 3 0 0 3 3 3 1 PHD-finger Peptidase_M24 PF00557.24 EEA07238.1 - 1.2e-18 67.6 0.2 1.6e-18 67.2 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Herpes_UL73 PF03554.13 EEA07239.1 - 0.15 12.1 8.8 0.22 11.5 8.8 1.3 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein adh_short PF00106.25 EEA07240.1 - 1.1e-38 132.7 0.0 1.3e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EEA07240.1 - 7.1e-20 71.6 0.0 9.2e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EEA07240.1 - 6.4e-07 29.4 0.0 9.4e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EEA07240.1 - 0.0016 18.0 0.0 0.0029 17.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF5399 PF17377.2 EEA07240.1 - 0.019 14.8 0.2 0.039 13.8 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5399) Nucleoporin2 PF04096.14 EEA07241.1 - 2.9e-38 131.3 0.0 8.3e-38 129.8 0.0 1.9 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 EEA07241.1 - 1.7e-22 79.9 2.7 3.1e-22 79.0 2.7 1.4 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin_FG PF13634.6 EEA07241.1 - 2.1e-05 25.3 233.4 0.0022 18.8 23.5 9.1 2 2 7 9 9 9 6 Nucleoporin FG repeat region Rrp15p PF07890.12 EEA07242.1 - 7e-09 36.1 7.3 1.5e-08 35.1 7.3 1.5 1 1 0 1 1 1 1 Rrp15p rRNA_methylase PF06962.12 EEA07242.1 - 0.031 14.2 0.2 0.048 13.6 0.2 1.3 1 0 0 1 1 1 0 Putative rRNA methylase DUF4404 PF14357.6 EEA07242.1 - 0.27 11.9 2.5 0.31 11.7 0.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) DUF3335 PF11814.8 EEA07242.1 - 0.69 9.4 3.2 0.43 10.0 0.7 1.7 1 1 1 2 2 2 0 Peptidase_C39 like family Prenyltrans PF00432.21 EEA07243.1 - 9.9e-22 76.4 0.1 9.1e-12 44.5 0.0 5.1 4 1 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat zf-CSL PF05207.13 EEA07244.1 - 4.1e-14 52.1 0.6 5.2e-14 51.7 0.6 1.2 1 0 0 1 1 1 1 CSL zinc finger DEAD PF00270.29 EEA07245.1 - 1.7e-45 154.9 0.2 1e-44 152.4 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA07245.1 - 6.9e-26 90.8 0.7 1.8e-24 86.2 0.1 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EEA07245.1 - 3e-07 29.9 0.1 8.7e-07 28.4 0.1 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Gaa1 PF04114.14 EEA07247.1 - 1.1e-26 93.9 7.4 5.8e-16 58.6 0.0 2.8 2 1 0 2 2 2 2 Gaa1-like, GPI transamidase component Ribosomal_L12_N PF16320.5 EEA07247.1 - 0.11 12.2 0.1 11 5.8 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain DUF4064 PF13273.6 EEA07247.1 - 3 8.2 7.0 5.5 7.3 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) PDEase_I PF00233.19 EEA07248.1 - 3.3e-67 226.7 0.0 5.8e-67 225.9 0.0 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF456 PF04306.13 EEA07248.1 - 0.0075 16.6 3.9 0.019 15.3 3.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF456) Phage_holin_1 PF04531.13 EEA07248.1 - 0.17 12.5 0.8 0.99 10.0 0.8 2.4 1 1 0 1 1 1 0 Bacteriophage holin RRM_1 PF00076.22 EEA07249.1 - 1.4e-16 60.0 0.0 1.9e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA07249.1 - 9.6e-07 28.4 0.0 1.2e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.29 EEA07250.1 - 1e-16 61.6 0.0 3.9e-14 53.2 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA07250.1 - 2.9e-05 24.5 0.1 0.06 13.7 0.1 2.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_14 PF13173.6 EEA07250.1 - 0.00013 22.0 2.9 0.14 12.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 EEA07250.1 - 0.00015 21.7 0.0 0.81 9.6 0.0 2.6 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.22 EEA07250.1 - 0.00023 21.5 0.0 1.1 9.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 EEA07250.1 - 0.00023 21.3 0.0 0.22 11.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain KAP_NTPase PF07693.14 EEA07250.1 - 0.00052 19.4 0.1 0.68 9.1 0.0 2.4 2 0 0 2 2 2 2 KAP family P-loop domain AAA_22 PF13401.6 EEA07250.1 - 0.0006 20.1 0.0 0.27 11.5 0.1 3.0 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EEA07250.1 - 0.00099 19.6 0.1 0.22 12.0 0.0 2.4 2 0 0 2 2 2 1 ABC transporter TsaE PF02367.17 EEA07250.1 - 0.0011 18.9 0.0 0.52 10.3 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2791 PF10923.8 EEA07250.1 - 0.0026 16.6 0.1 0.073 11.9 0.0 2.1 2 0 0 2 2 2 1 P-loop Domain of unknown function (DUF2791) Viral_helicase1 PF01443.18 EEA07250.1 - 0.005 16.6 0.0 0.22 11.2 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EEA07250.1 - 0.01 16.3 0.3 3.2 8.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EEA07250.1 - 0.017 14.6 0.0 5.8 6.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 EEA07250.1 - 0.024 14.4 0.1 6.7 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain cobW PF02492.19 EEA07250.1 - 0.029 14.0 0.3 3.2 7.3 0.0 2.7 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EEA07250.1 - 0.032 14.2 0.0 3 7.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EEA07250.1 - 0.036 13.3 0.0 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.13 EEA07250.1 - 0.037 13.2 0.0 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) dNK PF01712.19 EEA07250.1 - 0.048 13.5 1.3 7.8 6.3 0.0 3.0 3 0 0 3 3 3 0 Deoxynucleoside kinase MobB PF03205.14 EEA07250.1 - 0.048 13.6 0.1 7 6.5 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 EEA07250.1 - 0.12 12.1 0.1 17 5.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EEA07250.1 - 0.14 11.2 0.1 2.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein CENP-H PF05837.12 EEA07252.1 - 0.45 10.9 3.4 6.1 7.3 0.4 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) UTP15_C PF09384.10 EEA07253.1 - 5.8e-36 123.4 0.5 8.2e-36 122.9 0.5 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EEA07253.1 - 1.8e-12 47.5 0.8 0.15 13.0 0.2 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07253.1 - 6.6e-07 29.5 0.0 0.00011 22.4 0.0 3.9 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2113 PF09886.9 EEA07254.1 - 0.077 12.3 0.0 9.3 5.5 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2113) SAC3_GANP PF03399.16 EEA07255.1 - 3.1e-57 194.2 1.7 3.7e-57 194.0 1.7 1.0 1 0 0 1 1 1 1 SAC3/GANP family PARG_cat PF05028.14 EEA07256.1 - 0.031 13.6 0.6 0.04 13.2 0.6 1.1 1 0 0 1 1 1 0 Poly (ADP-ribose) glycohydrolase (PARG) Ribosomal_L37ae PF01780.19 EEA07257.1 - 1e-36 124.9 7.5 1.2e-36 124.7 7.5 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EEA07257.1 - 0.007 16.3 4.5 0.012 15.6 4.5 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-RING_13 PF17977.1 EEA07257.1 - 0.058 13.5 3.0 0.081 13.1 3.0 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-BED PF02892.15 EEA07257.1 - 0.068 13.2 3.3 1 9.4 0.7 2.5 1 1 1 2 2 2 0 BED zinc finger UMP1 PF05348.11 EEA07258.1 - 1.9e-15 57.2 0.0 2e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Nkap_C PF06047.11 EEA07259.1 - 7.7e-45 151.2 4.9 1.3e-44 150.5 4.9 1.3 1 0 0 1 1 1 1 NF-kappa-B-activating protein C-terminal domain UQ_con PF00179.26 EEA07260.1 - 1e-48 164.5 0.1 1.2e-48 164.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EEA07260.1 - 0.01 15.7 0.1 0.02 14.8 0.1 1.5 1 1 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 EEA07260.1 - 0.014 15.1 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EEA07260.1 - 0.097 13.0 0.2 0.12 12.7 0.2 1.4 1 0 0 1 1 1 0 RWD domain REPA_OB_2 PF16900.5 EEA07261.1 - 3.6e-30 103.8 0.6 2.8e-26 91.3 0.1 2.7 2 0 0 2 2 2 2 Replication protein A OB domain Rep_fac-A_C PF08646.10 EEA07261.1 - 1.4e-18 67.0 1.1 3.5e-18 65.7 1.1 1.6 1 0 0 1 1 1 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.25 EEA07261.1 - 2.3e-10 40.3 0.4 7.3e-07 29.1 0.0 3.4 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EEA07261.1 - 0.00014 21.7 1.9 0.0031 17.3 0.8 2.9 2 1 0 2 2 2 1 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 EEA07261.1 - 0.0011 19.2 0.3 0.004 17.4 0.3 1.9 1 0 0 1 1 1 1 Domain of unknown function DUF223 BRCA-2_OB3 PF09104.10 EEA07261.1 - 0.0012 18.5 0.1 0.018 14.7 0.0 2.5 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 LPD3 PF18798.1 EEA07261.1 - 0.025 14.8 1.1 0.079 13.2 0.1 2.5 2 1 0 2 2 2 0 Large polyvalent protein-associated domain 3 zinc-ribbons_6 PF07191.12 EEA07261.1 - 0.075 13.0 0.9 0.16 12.0 0.9 1.5 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.7 EEA07261.1 - 0.1 12.6 0.8 0.22 11.6 0.8 1.5 1 0 0 1 1 1 0 Double zinc ribbon Proteasome PF00227.26 EEA07262.1 - 2.3e-45 154.4 0.1 2.9e-45 154.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA07262.1 - 9.7e-13 47.5 0.1 1.9e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Lipoprotein_17 PF04200.12 EEA07262.1 - 0.12 12.7 0.3 0.4 11.1 0.1 1.8 2 0 0 2 2 2 0 Lipoprotein associated domain Asp_protease PF09668.10 EEA07263.1 - 2.1e-55 185.8 0.9 3.3e-55 185.2 0.9 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EEA07263.1 - 1.1e-16 61.1 0.1 2.8e-16 59.8 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease ubiquitin PF00240.23 EEA07263.1 - 5.7e-10 38.8 0.0 1.2e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Asp_protease_2 PF13650.6 EEA07263.1 - 2.7e-09 37.5 0.2 8.3e-09 36.0 0.1 1.9 2 0 0 2 2 2 1 Aspartyl protease UBA PF00627.31 EEA07263.1 - 2.5e-08 33.7 0.1 4.9e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RVP PF00077.20 EEA07263.1 - 8.7e-06 26.0 0.0 2.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF1296 PF06972.11 EEA07263.1 - 0.0076 16.4 0.1 0.024 14.8 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1296) UN_NPL4 PF11543.8 EEA07263.1 - 0.0078 16.7 0.3 0.045 14.2 0.1 2.5 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 Sda PF08970.10 EEA07263.1 - 0.015 15.1 0.0 8.4 6.2 0.0 2.6 2 0 0 2 2 2 0 Sporulation inhibitor A Rad60-SLD PF11976.8 EEA07263.1 - 0.016 15.0 0.0 0.044 13.6 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 EEA07263.1 - 0.13 12.1 0.2 0.33 10.8 0.2 1.7 1 0 0 1 1 1 0 UBA-like domain ketoacyl-synt PF00109.26 EEA07264.1 - 3.9e-216 714.7 1.8 4.7e-78 262.3 0.3 3.6 3 0 0 3 3 3 3 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EEA07264.1 - 5.5e-174 573.8 0.2 3.1e-60 203.2 0.0 4.3 5 0 0 5 5 4 3 KR domain Acyl_transf_1 PF00698.21 EEA07264.1 - 4.5e-123 410.8 0.0 3e-51 174.8 0.0 3.3 3 0 0 3 3 3 3 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EEA07264.1 - 1.5e-120 395.9 9.1 2.1e-41 140.7 1.3 3.6 3 0 0 3 3 3 3 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EEA07264.1 - 4.6e-68 229.6 0.0 1.2e-27 96.9 0.0 4.6 3 2 0 3 3 3 3 Polyketide synthase dehydratase NAD_binding_4 PF07993.12 EEA07264.1 - 2.2e-61 207.3 0.0 4.2e-54 183.4 0.0 4.7 4 0 0 4 4 4 3 Male sterility protein AMP-binding PF00501.28 EEA07264.1 - 9.8e-61 205.6 0.0 1.3e-35 122.8 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 EEA07264.1 - 1.4e-54 182.3 2.5 1.5e-14 54.1 0.0 4.7 4 0 0 4 4 4 4 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 EEA07264.1 - 5.6e-50 168.7 0.0 1.3e-14 54.3 0.0 4.3 4 0 0 4 4 4 3 Zinc-binding dehydrogenase adh_short PF00106.25 EEA07264.1 - 2e-36 125.3 10.5 4.9e-12 45.7 0.0 6.6 6 0 0 6 6 6 6 short chain dehydrogenase adh_short_C2 PF13561.6 EEA07264.1 - 3.5e-33 115.1 1.8 2.3e-09 37.2 0.0 6.4 6 0 0 6 6 6 6 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EEA07264.1 - 3.3e-29 102.0 1.6 1.9e-08 34.1 0.0 5.1 5 0 0 5 5 5 4 NAD dependent epimerase/dehydratase family ADH_zinc_N_2 PF13602.6 EEA07264.1 - 1.4e-25 90.9 0.0 2.5e-06 28.6 0.0 4.2 4 0 0 4 4 4 3 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EEA07264.1 - 1.9e-24 86.2 0.0 6.8e-07 29.7 0.0 4.1 3 0 0 3 3 3 3 Ketoacyl-synthetase C-terminal extension GDP_Man_Dehyd PF16363.5 EEA07264.1 - 5.6e-18 65.4 0.6 0.0014 18.1 0.0 5.1 5 0 0 5 5 5 3 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EEA07264.1 - 2.2e-17 63.0 1.4 0.0015 17.6 0.1 5.0 4 1 0 4 4 4 3 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EEA07264.1 - 2e-15 56.7 0.5 0.0018 17.4 0.0 4.1 4 0 0 4 4 4 3 Polysaccharide biosynthesis protein ADH_N PF08240.12 EEA07264.1 - 8.3e-13 48.2 19.1 0.00028 20.7 0.1 5.6 7 0 0 7 7 6 3 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EEA07264.1 - 2.3e-10 40.3 13.5 0.00016 21.1 0.1 4.1 4 0 0 4 4 4 3 Thiolase, N-terminal domain 2-Hacid_dh_C PF02826.19 EEA07264.1 - 6.1e-05 22.5 3.2 6.7 6.0 0.0 5.2 4 3 0 4 4 4 3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AMP-binding_C_2 PF14535.6 EEA07264.1 - 0.0014 18.9 0.0 0.005 17.1 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 EEA07264.1 - 0.01 15.7 0.0 64 3.4 0.0 5.3 6 1 0 6 6 6 0 NAD(P)H-binding AlaDh_PNT_C PF01262.21 EEA07264.1 - 0.015 14.6 8.0 7.6 5.8 0.2 3.5 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 EEA07264.1 - 0.055 13.5 0.4 44 4.1 0.0 3.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase eIF_4EBP PF05456.11 EEA07264.1 - 0.091 12.7 0.9 1.1e+02 2.8 0.0 3.6 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Proteasome PF00227.26 EEA07265.1 - 1.1e-34 119.6 0.4 1.4e-34 119.3 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA07265.1 - 1.5e-12 47.0 0.0 2.3e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SprT-like PF10263.9 EEA07266.1 - 2.6e-27 94.9 0.1 5.4e-27 93.9 0.0 1.5 2 0 0 2 2 2 1 SprT-like family Peptidase_M76 PF09768.9 EEA07266.1 - 0.067 13.0 0.1 0.14 11.9 0.1 1.6 1 1 1 2 2 2 0 Peptidase M76 family WLM PF08325.10 EEA07266.1 - 0.19 11.8 0.1 0.33 11.0 0.1 1.3 1 0 0 1 1 1 0 WLM domain PTPLA PF04387.14 EEA07267.1 - 3.6e-49 166.7 8.4 5.6e-49 166.0 8.4 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA DUF3938 PF13074.6 EEA07267.1 - 0.39 11.0 3.8 0.3 11.3 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3938) Myosin_head PF00063.21 EEA07270.1 - 2.5e-28 98.7 4.3 2.3e-23 82.3 0.0 4.2 3 1 0 3 3 3 3 Myosin head (motor domain) RCC1 PF00415.18 EEA07270.1 - 2.9e-27 95.0 9.2 4.3e-10 40.1 0.1 7.0 6 2 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA07270.1 - 8.7e-11 41.3 32.1 7e-05 22.5 0.4 7.8 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat IQ PF00612.27 EEA07270.1 - 2.6e-10 39.2 35.5 0.001 18.6 0.6 7.6 7 0 0 7 7 7 5 IQ calmodulin-binding motif Nop PF01798.18 EEA07272.1 - 8e-83 277.4 0.6 1.8e-82 276.3 0.0 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EEA07272.1 - 2.2e-17 63.2 0.3 5.1e-17 62.0 0.3 1.7 1 0 0 1 1 1 1 NOP5NT (NUC127) domain SF1-HH PF16275.5 EEA07272.1 - 0.035 14.4 0.3 0.22 11.9 0.1 2.4 2 0 0 2 2 2 0 Splicing factor 1 helix-hairpin domain PS_Dcarbxylase PF02666.15 EEA07273.1 - 1.7e-47 161.5 0.0 2.2e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Ribosomal_S2 PF00318.20 EEA07274.1 - 7.6e-24 84.1 2.5 2.4e-13 49.8 0.4 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Pox_A22 PF04848.13 EEA07274.1 - 0.065 13.4 0.6 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Poxvirus A22 protein 40S_SA_C PF16122.5 EEA07274.1 - 0.23 12.9 6.9 0.51 11.7 0.5 2.3 1 1 1 2 2 2 0 40S ribosomal protein SA C-terminus Ion_trans_2 PF07885.16 EEA07275.1 - 3.4e-11 42.9 10.3 1.2e-10 41.1 10.3 2.0 1 0 0 1 1 1 1 Ion channel BK_channel_a PF03493.18 EEA07275.1 - 4.2e-11 42.9 1.1 2.5e-08 34.0 0.9 3.8 2 1 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 EEA07275.1 - 0.0084 15.4 21.2 0.018 14.3 21.2 1.5 1 0 0 1 1 1 1 Ion transport protein Lig_chan PF00060.26 EEA07275.1 - 0.029 14.2 1.5 0.088 12.6 1.5 1.8 1 0 0 1 1 1 0 Ligand-gated ion channel F-actin_cap_A PF01267.17 EEA07276.1 - 3.2e-18 66.1 0.7 1e-17 64.5 0.2 1.9 2 0 0 2 2 2 1 F-actin capping protein alpha subunit zf-C2HC_2 PF13913.6 EEA07277.1 - 0.19 11.7 1.6 0.33 10.9 1.6 1.5 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.6 EEA07279.1 - 2.9e-11 43.4 3.8 2.9e-11 43.4 3.8 2.5 2 0 0 2 2 2 1 zinc-ribbon zf-RING_2 PF13639.6 EEA07279.1 - 8e-11 42.1 6.2 8e-11 42.1 6.2 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA07279.1 - 3.7e-07 29.9 5.8 3.7e-07 29.9 5.8 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA07279.1 - 1.3e-06 28.6 8.3 1.3e-06 28.6 8.3 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EEA07279.1 - 3.1e-05 23.8 5.8 3.1e-05 23.8 5.8 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA07279.1 - 0.00011 21.9 2.8 0.00011 21.9 2.8 2.0 2 0 0 2 2 2 1 RING-like zinc finger FANCL_C PF11793.8 EEA07279.1 - 0.00019 21.5 1.7 0.0006 19.9 1.7 1.9 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EEA07279.1 - 0.00084 19.4 3.7 0.0021 18.0 3.7 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EEA07279.1 - 0.0026 17.7 3.9 0.0026 17.7 3.9 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA07279.1 - 0.0035 17.3 4.1 0.0035 17.3 4.1 2.3 2 1 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA07279.1 - 0.0099 15.7 4.0 0.0099 15.7 4.0 2.3 2 2 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EEA07279.1 - 0.027 14.3 1.8 0.027 14.3 1.8 2.4 2 1 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) DUF2387 PF09526.10 EEA07279.1 - 0.14 12.3 0.7 1.5 9.0 0.5 2.7 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) PHD PF00628.29 EEA07279.1 - 0.51 10.3 12.3 2 8.4 4.2 2.6 2 0 0 2 2 2 0 PHD-finger Zn_ribbon_17 PF17120.5 EEA07279.1 - 4.2 7.1 13.5 0.048 13.3 3.4 2.4 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Tape_meas_lam_C PF09718.10 EEA07279.1 - 4.8 7.4 8.1 0.55 10.4 0.2 3.1 3 1 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) zf-RING_9 PF13901.6 EEA07279.1 - 5.6 6.9 6.9 0.98 9.4 1.0 2.2 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Elf1 PF05129.13 EEA07279.1 - 6.8 6.8 5.7 4.2 7.5 0.6 2.7 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like 2OG-FeII_Oxy_3 PF13640.6 EEA07280.1 - 2.5e-09 37.9 0.0 4.1e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PolyA_pol PF01743.20 EEA07281.1 - 4.9e-25 88.4 0.2 2.5e-24 86.1 0.2 2.1 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EEA07281.1 - 0.044 13.5 0.3 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A Choline_kinase PF01633.20 EEA07282.1 - 1.4e-44 152.2 0.0 2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EEA07282.1 - 6e-07 29.6 0.0 1.1e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family PP2C PF00481.21 EEA07283.1 - 1.8e-61 208.0 0.1 6.8e-50 170.1 0.2 2.6 3 0 0 3 3 3 2 Protein phosphatase 2C RNase_P_Rpp14 PF01900.19 EEA07284.1 - 6.2e-15 55.3 0.3 8.9e-15 54.8 0.3 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family EF-hand_8 PF13833.6 EEA07285.1 - 0.054 13.4 0.1 0.22 11.4 0.2 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EEA07285.1 - 0.11 12.1 0.1 0.32 10.7 0.1 1.9 1 0 0 1 1 1 0 EF hand MH1 PF03165.16 EEA07285.1 - 0.29 11.4 1.5 1.3 9.2 0.2 2.4 2 0 0 2 2 2 0 MH1 domain WD40 PF00400.32 EEA07286.1 - 0.00045 21.0 0.3 0.22 12.4 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Gp5_OB PF06714.11 EEA07287.1 - 0.031 14.5 0.0 0.12 12.6 0.0 2.0 1 0 0 1 1 1 0 Gp5 N-terminal OB domain HUN PF08729.10 EEA07287.1 - 0.12 12.4 16.5 1.2 9.2 16.5 2.7 1 1 0 1 1 1 0 HPC2 and ubinuclein domain AP2 PF00847.20 EEA07288.1 - 0.52 10.6 3.8 0.45 10.8 0.1 2.6 2 1 0 2 2 2 0 AP2 domain MTBP_C PF14920.6 EEA07288.1 - 0.71 9.6 8.2 0.069 12.9 2.5 2.2 2 0 0 2 2 2 0 MDM2-binding Nbl1_Borealin_N PF10444.9 EEA07289.1 - 0.011 15.3 0.1 0.011 15.3 0.1 2.5 3 1 0 3 3 3 0 Nbl1 / Borealin N terminal MukF_C PF17193.4 EEA07289.1 - 0.051 13.7 1.0 0.06 13.5 0.4 1.4 2 0 0 2 2 2 0 MukF C-terminal domain IFT20 PF14931.6 EEA07289.1 - 0.055 13.7 0.7 0.055 13.7 0.7 2.6 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 ATG16 PF08614.11 EEA07289.1 - 0.12 12.6 5.9 0.22 11.7 5.8 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Nup54 PF13874.6 EEA07289.1 - 0.19 11.9 3.9 0.2 11.8 3.1 1.5 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Mst1_SARAH PF11629.8 EEA07289.1 - 0.24 11.5 4.0 6.4 7.0 0.1 3.0 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 Fib_alpha PF08702.10 EEA07289.1 - 1 9.5 9.0 1.2 9.3 8.5 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SAP30_Sin3_bdg PF13867.6 EEA07290.1 - 0.019 15.3 0.4 0.049 14.0 0.4 1.8 1 1 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Imm48 PF15574.6 EEA07290.1 - 0.052 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 48 NUDIX PF00293.28 EEA07291.1 - 7.4e-13 48.7 0.0 9.3e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain TCTP PF00838.17 EEA07292.1 - 9.6e-49 165.9 0.5 1.1e-48 165.7 0.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein LapA_dom PF06305.11 EEA07293.1 - 0.49 10.3 4.0 0.17 11.7 0.5 2.2 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Claudin_3 PF06653.11 EEA07293.1 - 3.7 7.5 25.7 0.059 13.3 16.4 2.4 2 1 1 3 3 3 0 Tight junction protein, Claudin-like DUF2207 PF09972.9 EEA07293.1 - 3.7 6.2 17.0 17 4.0 17.0 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Vpu PF00558.19 EEA07293.1 - 5.7 6.8 8.0 1 9.2 0.2 2.8 2 0 0 2 2 2 0 Vpu protein PRP38 PF03371.15 EEA07294.1 - 4.3e-49 166.7 0.5 5.3e-49 166.4 0.5 1.1 1 0 0 1 1 1 1 PRP38 family SART-1 PF03343.13 EEA07294.1 - 0.0021 16.7 0.2 0.003 16.2 0.2 1.2 1 0 0 1 1 1 1 SART-1 family BetaGal_dom4_5 PF13364.6 EEA07295.1 - 0.035 14.7 0.1 0.33 11.5 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain Acetyltransf_1 PF00583.25 EEA07296.1 - 3.1e-08 33.8 0.0 5.4e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA07296.1 - 0.00048 20.5 0.0 0.0011 19.4 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA07296.1 - 0.00066 19.6 0.0 0.0017 18.3 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain DUF4635 PF15466.6 EEA07296.1 - 0.00066 19.2 0.1 0.0024 17.4 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4635) Acetyltransf_4 PF13420.7 EEA07296.1 - 0.019 15.1 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DSPc PF00782.20 EEA07297.1 - 2.2e-07 30.8 0.0 6.1e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA07297.1 - 0.00043 19.9 0.0 0.0026 17.4 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EEA07297.1 - 0.02 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 EEA07297.1 - 0.025 14.2 0.0 0.06 13.0 0.0 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) RRM_1 PF00076.22 EEA07298.1 - 4.4e-16 58.4 0.2 1.2e-11 44.2 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lsm_interact PF05391.11 EEA07298.1 - 0.033 13.7 3.0 0.08 12.5 3.0 1.7 1 0 0 1 1 1 0 Lsm interaction motif UN_NPL4 PF11543.8 EEA07298.1 - 0.53 10.8 5.1 40 4.8 0.0 3.9 2 1 1 3 3 3 0 Nuclear pore localisation protein NPL4 RNA_POL_M_15KD PF02150.16 EEA07299.1 - 1.3e-07 31.3 7.2 1.3e-07 31.3 7.2 3.3 4 0 0 4 4 4 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EEA07299.1 - 1.6e-07 31.0 0.5 1.6e-07 31.0 0.5 3.1 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS) DZR PF12773.7 EEA07299.1 - 0.0078 16.2 7.3 0.32 11.1 1.2 2.7 2 1 0 2 2 2 2 Double zinc ribbon DUF3795 PF12675.7 EEA07299.1 - 0.026 14.9 6.4 0.33 11.4 1.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3795) CDH-cyt PF16010.5 EEA07299.1 - 0.027 14.1 0.5 0.087 12.5 0.1 1.8 2 0 0 2 2 2 0 Cytochrome domain of cellobiose dehydrogenase DUF3268 PF11672.8 EEA07299.1 - 0.21 11.9 5.7 2.9 8.3 0.2 2.5 2 1 0 2 2 2 0 zinc-finger-containing domain zinc_ribbon_10 PF10058.9 EEA07299.1 - 0.31 10.8 12.4 1.8 8.4 0.2 3.5 3 1 1 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein A2L_zn_ribbon PF08792.10 EEA07299.1 - 0.45 10.3 0.1 0.45 10.3 0.1 4.3 4 1 0 4 4 4 0 A2L zinc ribbon domain IBR PF01485.21 EEA07299.1 - 6.4 7.1 12.4 3.7e+02 1.4 12.4 2.9 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain EGF_CA PF07645.15 EEA07300.1 - 1.5e-61 204.3 133.4 7e-12 45.4 7.4 10.2 10 1 0 10 10 10 8 Calcium-binding EGF domain cEGF PF12662.7 EEA07300.1 - 5.3e-52 173.3 64.1 2.4e-10 40.1 2.5 9.3 8 0 0 8 8 8 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 EEA07300.1 - 8.9e-31 105.9 125.0 2.1e-10 40.7 7.5 9.4 9 0 0 9 9 9 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 EEA07300.1 - 7.7e-16 58.0 105.5 0.00016 21.8 4.5 10.7 8 3 0 9 9 9 7 EGF domain hEGF PF12661.7 EEA07300.1 - 7.9e-13 48.5 96.9 0.0021 18.6 2.3 12.1 11 3 0 11 11 11 8 Human growth factor-like EGF EGF PF00008.27 EEA07300.1 - 7.4e-11 42.1 121.8 5.3e-05 23.4 6.7 10.6 9 0 0 9 9 9 6 EGF-like domain CK_II_beta PF01214.18 EEA07301.1 - 1.8e-61 207.1 0.1 3.5e-61 206.2 0.0 1.5 2 0 0 2 2 2 1 Casein kinase II regulatory subunit GP11 PF08677.10 EEA07303.1 - 0.011 15.2 3.2 1.6 8.1 0.1 3.2 2 1 1 3 3 3 0 GP11 baseplate wedge protein Sec23_trunk PF04811.15 EEA07304.1 - 5.8e-65 219.2 0.0 8.3e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EEA07304.1 - 9.9e-31 106.3 0.1 2e-30 105.4 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EEA07304.1 - 1.7e-12 47.1 0.1 6e-12 45.3 0.1 1.9 1 1 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 EEA07304.1 - 2.9e-12 46.4 4.5 6e-12 45.4 4.5 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EEA07304.1 - 3.5e-06 26.8 3.5 0.0027 17.5 0.3 2.9 2 1 1 3 3 3 2 Sec23/Sec24 helical domain VP_N-CPKC PF11475.8 EEA07304.1 - 0.17 11.8 0.7 0.49 10.4 0.7 1.7 1 0 0 1 1 1 0 Virion protein N terminal domain Pkinase PF00069.25 EEA07305.1 - 3.2e-26 92.3 0.0 4.2e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07305.1 - 2.1e-16 60.0 0.0 2.7e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA07305.1 - 1.6e-09 37.1 0.0 2.3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EEA07305.1 - 0.00028 20.9 0.0 0.0017 18.3 0.0 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EEA07305.1 - 0.027 13.5 0.2 0.042 12.8 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Vma12 PF11712.8 EEA07306.1 - 5.1 7.2 7.6 2.6 8.1 0.0 2.9 3 1 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CAS_CSE1 PF03378.15 EEA07307.1 - 2.9e-45 154.6 4.8 2.9e-45 154.6 4.8 2.8 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EEA07307.1 - 2.4e-42 145.1 0.4 3.7e-41 141.2 0.4 2.3 1 1 0 1 1 1 1 Cse1 IBN_N PF03810.19 EEA07307.1 - 3.2e-14 52.6 0.5 1.7e-13 50.3 0.1 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EEA07307.1 - 0.00022 21.3 1.5 0.00022 21.3 1.5 3.0 3 0 0 3 3 3 1 Exportin 1-like protein DUF1871 PF08958.10 EEA07307.1 - 0.18 12.1 0.8 0.99 9.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) zf-C3H2C3 PF17122.5 EEA07311.1 - 4.2e-09 36.3 11.1 1.4e-08 34.6 11.1 2.0 1 0 0 1 1 1 1 Zinc-finger Clathrin PF00637.20 EEA07311.1 - 0.0029 17.5 9.5 0.079 12.8 3.0 3.2 2 1 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 EEA07311.1 - 0.039 13.8 11.2 0.16 11.8 11.2 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DASH_Dad4 PF08650.10 EEA07311.1 - 0.042 13.8 0.0 0.38 10.8 0.0 2.7 1 0 0 1 1 1 0 DASH complex subunit Dad4 Herpes_heli_pri PF05774.11 EEA07311.1 - 0.058 13.6 2.6 0.074 13.3 0.2 2.6 3 0 0 3 3 3 0 Herpesvirus helicase-primase complex component zf-rbx1 PF12678.7 EEA07311.1 - 0.25 11.6 9.9 1.5 9.2 9.9 2.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EEA07311.1 - 1.9 8.6 5.5 1.7 8.7 3.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Ribosomal_S5 PF00333.20 EEA07312.1 - 2.2e-29 101.2 0.5 4.3e-29 100.3 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EEA07312.1 - 2.7e-21 74.8 0.0 5e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain SEP PF08059.13 EEA07313.1 - 6.4e-19 68.3 0.0 1.1e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 EEA07313.1 - 2.8e-09 37.0 0.1 9.6e-09 35.3 0.0 1.9 2 1 0 2 2 2 1 UBX domain GN3L_Grn1 PF08701.11 EEA07314.1 - 1.7e-16 60.1 21.3 2.9e-16 59.3 21.3 1.4 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EEA07314.1 - 3.5e-15 56.1 0.3 1e-13 51.4 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA07314.1 - 3.4e-05 23.4 0.2 3.4e-05 23.4 0.2 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EEA07314.1 - 0.00066 19.3 0.0 0.5 9.9 0.0 3.1 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA07314.1 - 0.0007 19.5 4.6 0.0016 18.3 0.2 2.6 3 0 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EEA07314.1 - 0.09 13.2 0.3 0.27 11.6 0.1 1.9 2 0 0 2 2 2 0 AAA ATPase domain Calici_MSP PF05752.11 EEA07314.1 - 0.1 12.4 0.6 0.19 11.5 0.6 1.5 1 0 0 1 1 1 0 Calicivirus minor structural protein FAM86 PF14904.6 EEA07314.1 - 0.12 12.5 2.7 0.32 11.1 0.1 2.8 2 1 0 3 3 3 0 Family of unknown function ABC_tran PF00005.27 EEA07314.1 - 0.15 12.6 1.4 2.7 8.5 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.6 EEA07314.1 - 0.15 12.6 2.7 0.29 11.7 0.0 2.6 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 EEA07314.1 - 0.2 10.6 0.1 0.2 10.6 0.1 2.1 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EEA07314.1 - 8.4 6.4 14.1 9.3 6.3 0.4 3.9 2 2 1 3 3 3 0 Dynamin family MFS_1 PF07690.16 EEA07315.1 - 4.7e-23 81.7 63.9 2.4e-18 66.2 37.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EEA07315.1 - 0.00031 19.7 1.3 0.00031 19.7 1.3 3.1 4 0 0 4 4 4 2 MFS_1 like family zf-B_box PF00643.24 EEA07316.1 - 2.5e-10 40.3 16.3 3.7e-05 23.8 3.7 2.5 2 0 0 2 2 2 2 B-box zinc finger GDI PF00996.18 EEA07317.1 - 9.1e-199 660.4 0.1 1.1e-198 660.1 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EEA07317.1 - 0.064 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Avidin PF01382.17 EEA07317.1 - 0.087 13.3 0.0 0.34 11.4 0.0 1.9 2 0 0 2 2 2 0 Avidin family FAD_binding_3 PF01494.19 EEA07317.1 - 0.19 10.9 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain CRAL_TRIO PF00650.20 EEA07318.1 - 1.2e-22 80.3 0.1 2.8e-22 79.1 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 EEA07318.1 - 2e-05 25.1 4.0 0.1 13.1 0.2 3.1 3 0 0 3 3 3 2 Golgi-dynamics membrane-trafficking Coatomer_E PF04733.14 EEA07319.1 - 2.5e-17 63.2 6.6 3.4e-10 39.8 0.2 3.0 1 1 1 2 2 2 2 Coatomer epsilon subunit TPR_2 PF07719.17 EEA07319.1 - 4.7e-08 32.5 0.3 0.01 15.9 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EEA07319.1 - 2.1e-06 28.2 0.0 0.026 15.0 0.0 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA07319.1 - 6.7e-06 26.3 0.0 0.22 11.8 0.0 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA07319.1 - 3.9e-05 23.3 4.5 0.87 9.5 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat PPR PF01535.20 EEA07319.1 - 9.5e-05 22.4 4.6 0.15 12.4 0.0 5.3 6 0 0 6 6 5 1 PPR repeat ANAPC3 PF12895.7 EEA07319.1 - 9.9e-05 22.5 1.4 0.007 16.6 0.2 3.5 3 1 1 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 EEA07319.1 - 0.00051 19.7 0.0 0.027 14.1 0.0 2.5 2 1 0 2 2 2 1 Bacterial type III secretion protein (HrpB1_HrpK) PPR_2 PF13041.6 EEA07319.1 - 0.016 15.4 0.4 13 6.1 0.0 4.4 5 0 0 5 5 4 0 PPR repeat family RPN7 PF10602.9 EEA07319.1 - 0.032 14.0 1.8 0.25 11.0 0.3 2.4 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Phage_Gp15 PF06854.11 EEA07319.1 - 0.039 13.9 4.2 0.14 12.1 4.3 2.0 1 1 0 1 1 1 0 Bacteriophage Gp15 protein TPR_16 PF13432.6 EEA07319.1 - 0.04 14.6 0.0 0.49 11.1 0.0 2.4 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EEA07319.1 - 0.043 14.6 0.0 2.8 9.0 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EEA07319.1 - 0.047 13.4 0.0 0.16 11.7 0.0 1.9 1 0 0 1 1 1 0 TPR repeat TPR_7 PF13176.6 EEA07319.1 - 0.09 12.9 0.0 2.5 8.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RFC1 PF08519.12 EEA07319.1 - 0.18 12.0 4.6 1.6 8.8 0.5 3.0 3 0 0 3 3 3 0 Replication factor RFC1 C terminal domain DUF155 PF02582.14 EEA07320.1 - 1.2e-50 172.0 0.1 1.8e-50 171.5 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Peptidase_C14 PF00656.22 EEA07321.1 - 3.8e-30 105.6 0.0 7e-30 104.8 0.0 1.5 1 0 0 1 1 1 1 Caspase domain Abhydrolase_1 PF00561.20 EEA07322.1 - 2.8e-10 40.3 0.0 1.1e-08 35.1 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA07322.1 - 3.2e-05 23.3 0.0 0.00078 18.8 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EEA07322.1 - 0.00043 19.1 0.0 0.00077 18.2 0.0 1.4 1 0 0 1 1 1 1 Ndr family Abhydrolase_6 PF12697.7 EEA07322.1 - 0.016 15.9 0.0 0.018 15.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sel1 PF08238.12 EEA07323.1 - 3.4e-07 30.7 10.1 0.032 14.9 0.3 5.6 6 0 0 6 6 6 3 Sel1 repeat Ham1p_like PF01725.16 EEA07324.1 - 2.3e-44 151.5 0.0 2.8e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Peptidase_M14 PF00246.24 EEA07325.1 - 2.4e-17 63.7 0.0 1e-16 61.6 0.0 2.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Luciferase_N PF05295.11 EEA07325.1 - 0.018 15.0 0.0 0.054 13.5 0.0 1.8 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain TPR_19 PF14559.6 EEA07326.1 - 4e-08 33.7 0.1 0.00056 20.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA07326.1 - 1.6e-05 24.7 1.0 1.3 9.3 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA07326.1 - 4.8e-05 23.8 0.0 0.077 13.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA07326.1 - 0.00038 20.2 3.6 0.33 10.8 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA07326.1 - 0.0038 17.3 0.1 1.7 9.1 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA07326.1 - 0.015 15.0 0.8 4.9 6.9 0.0 3.3 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 EEA07326.1 - 0.042 14.2 0.6 0.8 10.2 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 EEA07326.1 - 0.047 12.9 0.0 0.17 11.0 0.1 1.7 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 EEA07326.1 - 0.093 13.1 0.0 0.34 11.3 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 EEA07329.1 - 0.0025 18.1 0.2 0.015 15.6 0.0 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Cas9_PI2 PF18070.1 EEA07329.1 - 0.12 13.1 4.0 1.1 10.1 0.7 2.8 2 0 0 2 2 2 0 CRISPR-Cas9 PI domain Dus PF01207.17 EEA07330.1 - 6.3e-38 130.6 0.0 1e-37 129.9 0.0 1.3 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) OB_NTP_bind PF07717.16 EEA07331.1 - 1.4e-17 63.8 0.2 5.3e-17 61.9 0.1 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA07331.1 - 1.9e-15 57.1 1.8 1.1e-14 54.7 0.2 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EEA07331.1 - 8.2e-15 55.0 0.0 1.6e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 EEA07331.1 - 2.2e-11 43.8 0.2 5.3e-11 42.6 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA07331.1 - 3.1e-05 24.3 0.0 6.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EEA07331.1 - 0.00042 20.4 0.8 0.00042 20.4 0.8 2.3 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA07331.1 - 0.00057 19.0 0.2 0.0011 18.1 0.2 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EEA07331.1 - 0.00065 20.0 0.3 0.0017 18.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EEA07331.1 - 0.0043 16.3 0.0 0.0087 15.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EEA07331.1 - 0.0049 16.4 0.8 0.082 12.4 0.1 2.9 3 0 0 3 3 3 1 PhoH-like protein AAA_30 PF13604.6 EEA07331.1 - 0.0078 16.0 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EEA07331.1 - 0.008 16.7 2.1 0.028 14.9 0.2 2.7 3 1 1 4 4 4 1 ABC transporter Flavi_DEAD PF07652.14 EEA07331.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_29 PF13555.6 EEA07331.1 - 0.037 13.8 0.1 0.11 12.2 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase PF06745.13 EEA07331.1 - 0.042 13.2 0.4 0.13 11.6 0.1 1.9 2 0 0 2 2 2 0 KaiC AAA_23 PF13476.6 EEA07331.1 - 0.09 13.3 2.5 0.14 12.6 0.3 2.4 3 0 0 3 3 3 0 AAA domain DUF1229 PF06797.11 EEA07332.1 - 0.036 14.3 1.1 0.049 13.9 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1229) PAH PF02671.21 EEA07333.1 - 0.18 12.0 2.3 0.36 11.0 0.8 2.3 2 1 0 2 2 2 0 Paired amphipathic helix repeat DUF262 PF03235.14 EEA07333.1 - 0.21 11.7 5.6 0.27 11.4 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 GCP_N_terminal PF17681.1 EEA07334.1 - 1.4e-28 100.5 0.8 6.6e-28 98.2 0.8 2.1 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EEA07334.1 - 1.1e-15 57.9 9.9 5.6e-14 52.3 8.7 2.6 2 0 0 2 2 2 2 Gamma tubulin complex component C-terminal StbA PF06406.11 EEA07334.1 - 3.3 6.9 9.2 7 5.8 0.1 2.4 2 0 0 2 2 2 0 StbA protein Adaptin_N PF01602.20 EEA07335.1 - 3.5e-113 378.9 23.7 4.4e-113 378.6 23.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EEA07335.1 - 5.3e-50 169.6 12.9 1.3e-49 168.4 2.9 4.1 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA07335.1 - 3.4e-13 49.8 0.2 1.4e-06 28.6 0.0 4.7 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EEA07335.1 - 5.8e-12 44.8 1.9 0.00064 19.8 0.1 6.7 7 0 0 7 7 7 3 HEAT repeat FliG_C PF01706.16 EEA07335.1 - 0.0011 19.1 1.5 0.0043 17.2 0.5 2.6 2 0 0 2 2 2 1 FliG C-terminal domain HEAT_EZ PF13513.6 EEA07335.1 - 0.13 12.8 0.0 8.1 7.1 0.0 3.6 2 1 1 3 3 3 0 HEAT-like repeat FANCI_S2 PF14676.6 EEA07335.1 - 0.76 10.1 6.0 10 6.4 0.3 3.3 4 0 0 4 4 4 0 FANCI solenoid 2 Arm PF00514.23 EEA07335.1 - 1.5 9.0 4.4 25 5.1 0.0 4.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 EEA07335.1 - 2.5 8.7 6.6 2.4 8.8 0.1 3.5 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region DUF4503 PF14951.6 EEA07336.1 - 1.4 7.3 2.9 0.64 8.4 0.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4503) zf-RING_2 PF13639.6 EEA07337.1 - 1.2e-12 47.9 13.9 1.9e-12 47.3 13.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EEA07337.1 - 7.9e-10 38.4 9.1 1.2e-09 37.9 9.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA07337.1 - 3e-08 33.4 12.7 4.8e-08 32.7 12.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA07337.1 - 5.5e-08 32.7 10.4 1.2e-07 31.6 10.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA07337.1 - 1.3e-07 31.4 10.6 2.1e-07 30.8 10.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EEA07337.1 - 1.4e-07 31.2 13.0 2.7e-07 30.3 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EEA07337.1 - 4e-07 30.2 10.5 8.7e-07 29.1 10.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EEA07337.1 - 4.2e-06 26.4 9.3 4.2e-06 26.4 9.3 2.0 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 EEA07337.1 - 1.2e-05 25.0 10.0 2.2e-05 24.2 10.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Baculo_RING PF05883.11 EEA07337.1 - 0.0062 16.5 1.7 0.015 15.2 1.7 1.6 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain zf-ANAPC11 PF12861.7 EEA07337.1 - 0.019 15.0 6.2 0.04 14.0 6.2 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EEA07337.1 - 0.041 13.8 3.8 0.082 12.8 3.8 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EEA07337.1 - 0.46 10.7 14.0 2.7 8.2 14.0 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EEA07337.1 - 0.6 10.3 6.7 2 8.6 7.0 1.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-P11 PF03854.14 EEA07337.1 - 0.6 9.8 8.1 2.1 8.1 8.2 1.9 2 1 0 2 2 2 0 P-11 zinc finger zf-C3HC4_5 PF17121.5 EEA07337.1 - 1.4 8.8 7.2 4.4 7.3 7.2 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AAA PF00004.29 EEA07338.1 - 7.9e-14 52.2 0.0 1.9e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA07338.1 - 1.1e-11 45.2 0.0 2.5e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 EEA07338.1 - 2.9e-06 27.3 0.1 7.7e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 AAA lid domain AAA_16 PF13191.6 EEA07338.1 - 4.2e-06 27.3 0.0 5e-05 23.7 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EEA07338.1 - 0.00071 18.9 0.0 0.0017 17.7 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EEA07338.1 - 0.0018 18.1 1.0 0.0032 17.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA07338.1 - 0.022 14.7 0.0 0.23 11.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EEA07338.1 - 0.033 13.7 0.1 0.065 12.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EEA07338.1 - 0.062 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA07338.1 - 0.071 13.5 0.1 0.18 12.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EEA07338.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 EEA07339.1 - 0.021 15.1 2.3 0.021 15.1 2.3 6.1 5 2 1 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HOOK PF05622.12 EEA07339.1 - 0.037 12.2 48.9 0.53 8.4 48.7 2.4 1 1 0 1 1 1 0 HOOK protein Sugarporin_N PF11471.8 EEA07339.1 - 0.46 10.5 5.2 1.8 8.6 5.2 2.0 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension NPV_P10 PF05531.12 EEA07339.1 - 1.2 9.6 24.2 0.63 10.5 3.2 4.7 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DAGK_acc PF00609.19 EEA07340.1 - 1.5e-30 106.7 0.3 5e-17 62.7 0.0 2.4 1 1 1 2 2 2 2 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EEA07340.1 - 6.3e-16 58.1 0.0 1.3e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Phospholip_A2_1 PF00068.19 EEA07340.1 - 0.084 13.3 1.0 0.22 12.0 1.0 1.6 1 0 0 1 1 1 0 Phospholipase A2 zf-RING_2 PF13639.6 EEA07342.1 - 8.5e-06 26.0 14.4 9.5e-05 22.7 14.4 2.5 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EEA07342.1 - 1.8e-05 24.7 4.2 1.8e-05 24.7 4.2 2.3 2 0 0 2 2 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EEA07342.1 - 2.9e-05 23.6 4.8 2.9e-05 23.6 4.8 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EEA07342.1 - 0.00054 19.8 5.2 0.00054 19.8 5.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA07342.1 - 0.00055 19.6 6.8 0.0017 18.0 6.8 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EEA07342.1 - 0.0029 17.4 10.5 0.036 14.0 10.5 2.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA07342.1 - 0.004 17.1 9.3 0.023 14.6 9.3 2.3 1 1 0 1 1 1 1 zinc-RING finger domain APG6_N PF17675.1 EEA07342.1 - 0.011 16.3 15.9 0.054 14.0 10.3 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region zf-rbx1 PF12678.7 EEA07342.1 - 0.04 14.2 18.6 0.035 14.4 14.3 3.1 2 1 0 2 2 2 0 RING-H2 zinc finger domain Zf_RING PF16744.5 EEA07342.1 - 0.061 13.4 5.1 0.17 12.0 4.8 2.0 1 1 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_4 PF15227.6 EEA07342.1 - 0.12 12.6 6.7 0.057 13.6 2.8 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EEA07342.1 - 0.21 11.6 9.6 0.048 13.7 2.8 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 EEA07342.1 - 1.6 8.9 6.9 5.2 7.3 6.9 2.0 1 1 0 1 1 1 0 RING-variant domain zf-C3HC4_3 PF13920.6 EEA07342.1 - 2.2 8.2 10.6 7.3 6.5 3.8 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Fez1 PF06818.15 EEA07342.1 - 6.3 7.2 18.8 6 7.3 5.1 3.1 2 1 0 3 3 3 0 Fez1 Bromodomain PF00439.25 EEA07344.1 - 0.0023 18.0 1.5 0.0023 18.0 1.5 2.4 2 1 1 3 3 3 1 Bromodomain RsbU_N PF08673.10 EEA07344.1 - 0.0066 16.5 0.2 0.031 14.4 0.1 2.1 2 0 0 2 2 2 1 Phosphoserine phosphatase RsbU, N-terminal domain GST_C PF00043.25 EEA07344.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Elongin_A PF06881.11 EEA07345.1 - 0.00036 21.0 0.9 0.00077 20.0 0.4 1.8 1 1 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF5569 PF17729.1 EEA07345.1 - 0.022 14.6 0.7 0.03 14.2 0.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5569) DUF3161 PF11362.8 EEA07345.1 - 0.21 11.6 2.2 7.8 6.6 0.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3161) PHD PF00628.29 EEA07349.1 - 1e-11 44.5 8.8 1e-11 44.5 8.8 2.8 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 EEA07349.1 - 3.7e-07 30.4 23.5 1e-06 28.9 1.3 3.6 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EEA07349.1 - 1.1e-06 28.8 4.3 1.1e-06 28.8 4.3 3.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EEA07349.1 - 8.3e-06 25.7 3.9 8.3e-06 25.7 3.9 3.7 3 1 1 4 4 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EEA07349.1 - 1.9e-05 24.4 6.0 1.9e-05 24.4 6.0 3.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA07349.1 - 2.4e-05 24.1 3.3 2.4e-05 24.1 3.3 2.9 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EEA07349.1 - 7.8e-05 22.4 2.7 7.8e-05 22.4 2.7 3.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA07349.1 - 0.00011 22.0 2.2 0.00011 22.0 2.2 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA07349.1 - 0.00058 19.8 1.2 0.00058 19.8 1.2 3.6 2 1 1 3 3 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EEA07349.1 - 0.016 15.3 0.9 0.016 15.3 0.9 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EEA07349.1 - 0.02 15.0 0.4 0.02 15.0 0.4 2.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-P11 PF03854.14 EEA07349.1 - 0.058 13.1 4.9 0.39 10.4 1.4 3.0 2 0 0 2 2 2 0 P-11 zinc finger Caldesmon PF02029.15 EEA07349.1 - 4.9 5.8 57.6 8.9 4.9 57.6 1.4 1 0 0 1 1 1 0 Caldesmon Ribosomal_L39 PF00832.20 EEA07350.1 - 7.1e-21 73.6 10.3 7.9e-21 73.4 10.3 1.0 1 0 0 1 1 1 1 Ribosomal L39 protein RAI1 PF08652.11 EEA07350.1 - 0.017 15.3 0.1 0.019 15.1 0.1 1.1 1 0 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease eIF2A PF08662.11 EEA07351.1 - 1.3e-31 110.0 12.4 6.5e-25 88.1 3.3 4.7 4 1 1 5 5 5 2 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EEA07351.1 - 2.5e-06 28.1 0.7 0.46 11.4 0.0 5.3 4 1 1 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07351.1 - 3.2e-06 27.4 0.6 1.3 9.3 0.0 6.1 4 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 EEA07351.1 - 0.018 14.8 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PD40 PF07676.12 EEA07351.1 - 0.03 14.3 0.1 0.087 12.8 0.1 1.8 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat Pinin_SDK_memA PF04696.13 EEA07351.1 - 0.34 11.0 5.5 0.83 9.7 5.5 1.6 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region WD40 PF00400.32 EEA07352.1 - 1.6e-21 76.2 21.5 0.00017 22.3 0.5 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07352.1 - 5.4e-06 26.6 7.7 0.00027 21.2 2.1 4.2 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EEA07352.1 - 1.5e-05 23.9 5.5 3.3e-05 22.7 2.4 2.1 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Arm PF00514.23 EEA07353.1 - 6.8e-14 51.3 0.2 0.0012 18.8 0.0 4.3 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EEA07353.1 - 0.0031 17.9 0.8 0.058 13.8 0.2 3.2 2 1 2 4 4 4 2 HEAT repeats CoaE PF01121.20 EEA07354.1 - 6.5e-43 146.5 0.0 7.6e-43 146.2 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_28 PF13521.6 EEA07354.1 - 0.057 13.7 0.0 0.7 10.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain 7TM_GPCR_Srt PF10321.9 EEA07354.1 - 1.4 7.8 17.4 0.019 14.0 7.4 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srt Mito_carr PF00153.27 EEA07358.1 - 3.8e-60 199.8 0.2 6.8e-20 70.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EEA07358.1 - 0.02 14.1 0.1 0.36 9.9 0.0 2.6 2 1 1 3 3 3 0 Gammaproteobacterial serine protease Utp11 PF03998.13 EEA07359.1 - 8e-47 160.2 17.2 4.5e-46 157.8 17.2 1.8 1 1 0 1 1 1 1 Utp11 protein ZapB PF06005.12 EEA07360.1 - 0.019 15.4 6.2 0.019 15.4 6.2 8.6 1 1 3 5 5 5 0 Cell division protein ZapB Filament PF00038.21 EEA07360.1 - 8.2 5.9 77.6 6.5 6.2 9.2 3.8 1 1 2 3 3 3 0 Intermediate filament protein Mucin PF01456.17 EEA07364.1 - 0.59 10.1 23.3 4.8 7.2 0.3 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein Spore_III_AF PF09581.10 EEA07365.1 - 1.6 8.8 8.1 0.23 11.5 0.5 2.8 3 0 0 3 3 3 0 Stage III sporulation protein AF (Spore_III_AF) ABC_tran PF00005.27 EEA07368.1 - 3.7e-53 179.7 3.2 7.1e-31 107.6 0.1 3.2 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EEA07368.1 - 5.8e-27 95.0 30.0 7.3e-17 61.9 13.0 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EEA07368.1 - 6.7e-09 35.5 0.0 0.0062 16.0 0.0 3.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA07368.1 - 3.3e-07 30.4 8.7 0.064 13.1 0.1 5.2 3 2 2 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EEA07368.1 - 1.5e-06 28.7 0.0 0.00071 20.0 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EEA07368.1 - 4.4e-05 23.8 0.1 0.5 10.6 0.0 3.2 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EEA07368.1 - 0.0002 21.3 4.7 0.17 11.8 0.2 3.4 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EEA07368.1 - 0.00042 20.0 0.4 0.67 9.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA07368.1 - 0.00055 20.0 0.8 0.47 10.6 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 EEA07368.1 - 0.00078 19.1 0.7 0.51 9.9 0.1 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EEA07368.1 - 0.00084 19.9 0.5 3.5 8.2 0.0 3.6 4 0 0 4 4 3 2 AAA domain T2SSE PF00437.20 EEA07368.1 - 0.0061 15.7 4.5 0.17 10.9 0.1 3.0 3 0 0 3 3 3 1 Type II/IV secretion system protein NB-ARC PF00931.22 EEA07368.1 - 0.008 15.4 0.1 0.66 9.1 0.0 2.9 2 0 0 2 2 2 1 NB-ARC domain GTP_EFTU PF00009.27 EEA07368.1 - 0.013 15.1 0.5 1.1 8.7 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 EEA07368.1 - 0.017 15.5 0.0 2.5 8.5 0.0 3.3 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 EEA07368.1 - 0.021 15.2 4.0 0.093 13.2 0.2 3.7 3 2 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA07368.1 - 0.023 14.7 0.2 6.9 6.7 0.0 3.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EEA07368.1 - 0.029 13.9 0.1 9.9 5.6 0.0 2.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EEA07368.1 - 0.03 14.1 1.1 6 6.5 0.0 4.3 5 0 0 5 5 5 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EEA07368.1 - 0.039 13.7 0.0 6.3 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EEA07368.1 - 0.041 13.8 0.9 1.9 8.4 0.0 3.0 3 0 0 3 3 2 0 NACHT domain AAA_24 PF13479.6 EEA07368.1 - 0.045 13.5 1.2 6.8 6.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EEA07368.1 - 0.054 13.6 0.1 0.054 13.6 0.1 3.6 4 0 0 4 4 3 0 Helicase HerA, central domain MobB PF03205.14 EEA07368.1 - 0.071 13.0 0.6 3.1 7.7 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.25 EEA07368.1 - 0.097 12.3 0.1 4.4 6.9 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 EEA07368.1 - 0.14 12.3 0.1 7.1 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EEA07368.1 - 0.16 10.9 0.2 8.9 5.2 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_14 PF13173.6 EEA07368.1 - 0.31 11.1 0.0 0.31 11.1 0.0 5.0 7 0 0 7 7 7 0 AAA domain Dynamin_N PF00350.23 EEA07368.1 - 0.37 10.8 10.7 0.66 10.0 0.1 3.9 3 1 0 3 3 3 0 Dynamin family Roc PF08477.13 EEA07368.1 - 0.56 10.4 2.2 40 4.5 0.0 3.7 4 0 0 4 4 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_11 PF13086.6 EEA07368.1 - 0.92 9.2 4.8 1.5 8.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EEA07368.1 - 1.7 8.5 11.7 3.6 7.5 0.1 4.6 4 1 1 5 5 5 0 NTPase Pico_P1A PF02226.16 EEA07369.1 - 0.083 12.9 0.4 0.79 9.8 0.2 2.5 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) CAC1F_C PF16885.5 EEA07369.1 - 0.25 11.0 1.9 0.52 9.9 1.9 1.4 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term NIF PF03031.18 EEA07370.1 - 0.017 14.9 0.1 0.027 14.2 0.1 1.5 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase Glu_cyclase_2 PF05096.12 EEA07371.1 - 1.2e-45 155.9 0.0 2.5e-45 154.9 0.0 1.6 1 1 0 1 1 1 1 Glutamine cyclotransferase YqfQ PF14181.6 EEA07372.1 - 0.2 11.9 0.0 0.25 11.5 0.0 1.1 1 0 0 1 1 1 0 YqfQ-like protein SPRY PF00622.28 EEA07373.1 - 2.4e-07 30.9 0.1 0.0021 18.2 0.0 2.7 3 1 0 3 3 3 2 SPRY domain Rhodopsin_N PF10413.9 EEA07373.1 - 0.075 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Amino terminal of the G-protein receptor rhodopsin AAA_6 PF12774.7 EEA07374.1 - 2.4e-132 440.9 5.0 1.2e-106 356.4 0.0 6.0 6 1 1 7 7 6 3 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EEA07374.1 - 3.9e-92 309.4 14.8 7.7e-83 278.8 4.8 6.3 7 0 0 7 7 5 2 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 EEA07374.1 - 8.6e-83 278.9 11.6 8.6e-83 278.9 11.6 3.5 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 EEA07374.1 - 5.8e-64 215.2 0.0 5.8e-64 215.2 0.0 5.8 5 1 0 5 5 4 2 ATP-binding dynein motor region AAA_8 PF12780.7 EEA07374.1 - 1.3e-49 168.9 0.0 1.3e-48 165.6 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EEA07374.1 - 1.6e-40 138.5 0.2 4.6e-32 111.0 0.0 5.5 5 0 0 5 5 5 2 P-loop containing dynein motor region MT PF12777.7 EEA07374.1 - 1.2e-33 116.6 9.2 2.6e-33 115.5 9.2 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 EEA07374.1 - 1.5e-31 109.4 0.0 4.9e-31 107.8 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EEA07374.1 - 9e-27 93.8 0.0 2.7e-10 40.4 0.0 6.1 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) Dynein_C PF18199.1 EEA07374.1 - 2e-22 79.8 0.0 1.2e-21 77.2 0.0 2.5 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 EEA07374.1 - 2.1e-21 76.2 0.0 1.7e-20 73.3 0.1 2.7 2 0 0 2 2 1 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 EEA07374.1 - 1.3e-18 67.7 0.0 6.2e-05 23.4 0.0 6.6 6 0 0 6 6 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EEA07374.1 - 3.7e-12 46.7 1.3 0.0099 16.1 0.0 6.6 6 0 0 6 6 5 2 AAA domain Dynein_AAA_lid PF17852.1 EEA07374.1 - 4e-11 43.1 2.7 4.2e-10 39.8 0.2 3.6 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 EEA07374.1 - 3.6e-09 37.2 0.0 0.15 12.4 0.0 5.2 4 0 0 4 4 4 1 AAA ATPase domain AAA_19 PF13245.6 EEA07374.1 - 4e-06 27.2 0.7 0.64 10.3 0.0 5.8 6 0 0 6 6 5 1 AAA domain AAA_18 PF13238.6 EEA07374.1 - 5.9e-06 26.8 1.4 11 6.5 0.0 6.4 6 0 0 6 6 4 0 AAA domain Mg_chelatase PF01078.21 EEA07374.1 - 1e-05 25.1 3.5 0.11 11.8 0.0 4.0 4 0 0 4 4 3 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EEA07374.1 - 3.7e-05 23.5 0.2 0.093 12.5 0.0 4.3 4 0 0 4 4 4 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EEA07374.1 - 0.0001 22.5 0.4 1.6 8.8 0.0 4.8 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 EEA07374.1 - 0.00016 22.0 0.3 30 5.0 0.0 5.7 5 0 0 5 5 4 0 RNA helicase IstB_IS21 PF01695.17 EEA07374.1 - 0.00059 19.6 0.6 12 5.6 0.0 4.4 4 0 0 4 4 4 0 IstB-like ATP binding protein T2SSE PF00437.20 EEA07374.1 - 0.00064 18.9 0.0 1.5 7.8 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_25 PF13481.6 EEA07374.1 - 0.00069 19.2 0.0 0.39 10.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EEA07374.1 - 0.00087 19.1 0.1 5.2 6.7 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA_lid_1 PF17857.1 EEA07374.1 - 0.0027 17.9 1.9 0.041 14.1 0.2 3.5 3 0 0 3 3 2 1 AAA+ lid domain ATG16 PF08614.11 EEA07374.1 - 0.0033 17.7 19.7 0.0073 16.6 4.1 3.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Zeta_toxin PF06414.12 EEA07374.1 - 0.004 16.5 0.0 9.4 5.5 0.0 4.0 4 0 0 4 4 4 0 Zeta toxin Sigma54_activat PF00158.26 EEA07374.1 - 0.0041 16.8 0.0 9.8 5.9 0.0 3.6 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_29 PF13555.6 EEA07374.1 - 0.0056 16.4 0.2 1.9 8.3 0.1 4.5 4 0 0 4 4 4 1 P-loop containing region of AAA domain NACHT PF05729.12 EEA07374.1 - 0.006 16.5 0.3 26 4.7 0.0 5.0 4 0 0 4 4 4 0 NACHT domain AAA_24 PF13479.6 EEA07374.1 - 0.006 16.3 0.1 16 5.1 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 EEA07374.1 - 0.017 15.3 0.3 51 4.1 0.0 4.9 6 0 0 6 6 5 0 AAA domain RsgA_GTPase PF03193.16 EEA07374.1 - 0.03 14.2 0.0 18 5.2 0.0 3.9 3 0 0 3 3 3 0 RsgA GTPase POT1PC PF16686.5 EEA07374.1 - 0.032 14.1 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 ssDNA-binding domain of telomere protection protein AAA_11 PF13086.6 EEA07374.1 - 0.086 12.6 22.5 1.7 8.4 0.0 6.4 5 1 0 5 5 4 0 AAA domain ABC_tran PF00005.27 EEA07374.1 - 0.3 11.6 12.7 4 7.9 0.0 5.4 5 0 0 5 5 4 0 ABC transporter Na_Ca_ex_C PF16494.5 EEA07374.1 - 0.59 10.6 4.9 3.2 8.2 4.2 2.6 2 0 0 2 2 1 0 C-terminal extension of sodium/calcium exchanger domain DSPc PF00782.20 EEA07375.1 - 1.2e-19 70.4 1.8 2.5e-16 59.7 0.3 3.2 2 1 1 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EEA07375.1 - 0.0028 17.3 0.1 0.01 15.4 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase EF-hand_7 PF13499.6 EEA07375.1 - 0.07 13.6 0.3 0.26 11.8 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain pair CTF_NFI PF00859.18 EEA07375.1 - 0.19 11.6 2.4 0.41 10.5 1.3 1.8 2 0 0 2 2 2 0 CTF/NF-I family transcription modulation region TPR_12 PF13424.6 EEA07376.1 - 0.003 17.8 0.5 4.8 7.6 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA07376.1 - 0.33 11.2 10.2 0.2 11.9 1.8 3.1 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SPC25 PF06703.11 EEA07377.1 - 7.4e-10 38.8 1.2 1.3e-09 38.0 1.2 1.4 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) NKAIN PF05640.14 EEA07377.1 - 0.012 14.9 1.7 0.012 14.9 1.7 1.6 2 0 0 2 2 2 0 Na,K-Atpase Interacting protein zf-3CxxC PF13695.6 EEA07377.1 - 0.044 14.3 0.8 1 9.9 0.1 2.1 2 0 0 2 2 2 0 Zinc-binding domain DUF2759 PF10958.8 EEA07377.1 - 1 9.1 5.3 3.9 7.3 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2759) Thioredoxin PF00085.20 EEA07379.1 - 2.7e-33 114.0 0.0 5.9e-17 61.5 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EEA07379.1 - 1.6e-11 44.5 3.1 8.7e-10 38.8 0.3 2.8 4 0 0 4 4 4 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EEA07379.1 - 2.6e-06 27.4 0.1 0.031 14.2 0.0 3.3 4 0 0 4 4 4 2 AhpC/TSA family Thioredoxin_2 PF13098.6 EEA07379.1 - 3.7e-06 27.3 0.2 0.18 12.2 0.0 3.2 3 1 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EEA07379.1 - 3.5e-05 23.3 0.1 0.042 13.2 0.1 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 EEA07379.1 - 0.00033 20.4 0.0 1 9.2 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.6 EEA07379.1 - 0.00078 19.7 0.2 1.3 9.4 0.0 3.6 3 1 0 3 3 3 1 Thioredoxin-like Redoxin PF08534.10 EEA07379.1 - 0.0016 18.2 0.1 0.39 10.4 0.0 2.9 3 0 0 3 3 3 1 Redoxin Glutaredoxin PF00462.24 EEA07379.1 - 0.052 13.8 0.5 6.7 7.0 0.5 3.0 2 1 0 2 2 2 0 Glutaredoxin Thioredoxin_7 PF13899.6 EEA07379.1 - 0.073 13.3 0.1 0.51 10.6 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like Pkinase PF00069.25 EEA07380.1 - 8.5e-49 166.3 0.1 1.7e-48 165.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07380.1 - 2e-22 79.7 0.0 3.9e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA07380.1 - 0.065 13.1 0.4 0.14 12.1 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family IMPa_helical PF18642.1 EEA07380.1 - 0.16 12.4 1.8 9.2 6.7 0.1 2.6 2 0 0 2 2 2 0 Immunomodulating metalloprotease helical domain EB PF01683.18 EEA07380.1 - 4 7.8 12.4 0.27 11.6 5.5 2.6 3 0 0 3 3 3 0 EB module DHHC PF01529.20 EEA07381.1 - 5e-28 97.9 12.7 5e-28 97.9 12.7 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EEA07381.1 - 1.5e-19 70.4 0.0 2.1e-11 44.2 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA07381.1 - 1.8e-18 66.6 3.2 4.4e-08 33.5 0.1 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA07381.1 - 6.7e-14 50.6 0.0 0.00029 21.0 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EEA07381.1 - 7.9e-09 35.6 0.4 0.0059 17.0 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EEA07381.1 - 3.4e-08 33.6 0.0 0.00035 20.8 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) AAA_12 PF13087.6 EEA07382.1 - 1.1e-58 198.1 0.1 4.5e-58 196.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EEA07382.1 - 1.4e-54 185.6 6.2 4.8e-28 98.7 0.4 3.1 3 1 1 4 4 4 2 AAA domain AAA_19 PF13245.6 EEA07382.1 - 2.7e-09 37.5 0.0 0.0049 17.2 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EEA07382.1 - 2e-08 34.2 0.0 0.00015 21.5 0.0 2.5 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EEA07382.1 - 2e-05 24.5 0.2 0.043 13.5 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EEA07382.1 - 0.0059 16.6 0.0 0.044 13.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EEA07382.1 - 0.006 15.7 0.0 0.02 14.0 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA PF00004.29 EEA07382.1 - 0.014 15.8 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EEA07382.1 - 0.021 14.3 0.0 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 EEA07382.1 - 0.024 14.4 0.0 0.064 13.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA07382.1 - 0.028 14.7 0.0 0.086 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.6 EEA07382.1 - 0.037 13.9 0.4 7.9 6.4 0.2 2.5 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 EEA07382.1 - 0.042 13.1 0.8 0.34 10.1 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EEA07382.1 - 0.098 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain UvrD-helicase PF00580.21 EEA07382.1 - 1.3 8.5 12.0 0.44 10.0 0.1 3.9 3 1 1 4 4 4 0 UvrD/REP helicase N-terminal domain Mnd1 PF03962.15 EEA07383.1 - 7.3e-23 80.6 0.4 7.3e-23 80.6 0.4 2.4 3 0 0 3 3 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 EEA07383.1 - 9.2e-09 35.3 3.6 1e-08 35.1 1.3 2.3 2 0 0 2 2 2 1 Leucine zipper with capping helix domain UPF0242 PF06785.11 EEA07383.1 - 3.6e-05 24.0 9.7 5.8e-05 23.3 9.7 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Penicillinase_R PF03965.16 EEA07383.1 - 0.0019 18.5 0.8 0.0037 17.6 0.8 1.5 1 0 0 1 1 1 1 Penicillinase repressor KIP1 PF07765.12 EEA07383.1 - 0.035 14.2 3.6 0.035 14.2 3.6 2.9 2 2 1 3 3 3 0 KIP1-like protein TrmB PF01978.19 EEA07383.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF2203 PF09969.9 EEA07383.1 - 0.12 13.1 4.3 0.089 13.5 2.1 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DS PF01916.17 EEA07383.1 - 0.12 11.6 2.1 0.24 10.6 2.1 1.5 1 1 0 1 1 1 0 Deoxyhypusine synthase FIVAR PF07554.13 EEA07383.1 - 0.13 13.1 7.6 0.98 10.2 1.6 2.4 1 1 1 2 2 2 0 FIVAR domain Exonuc_VII_L PF02601.15 EEA07383.1 - 0.21 11.1 3.7 0.23 11.0 3.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin-6_N PF09177.11 EEA07383.1 - 0.21 12.2 11.0 0.14 12.8 8.7 1.9 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Fib_alpha PF08702.10 EEA07383.1 - 0.3 11.3 13.1 0.14 12.3 10.6 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 EEA07383.1 - 0.32 10.3 8.9 0.57 9.4 8.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 EEA07383.1 - 0.46 9.3 14.7 1.2 7.9 14.7 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 EEA07383.1 - 0.57 10.2 10.3 1.2 9.2 7.7 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF5344 PF17279.2 EEA07383.1 - 0.82 10.3 10.8 0.89 10.2 9.7 1.6 2 0 0 2 2 1 0 Family of unknown function (DUF5344) DUF848 PF05852.11 EEA07383.1 - 0.84 9.7 11.7 0.25 11.4 8.3 1.8 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF883 PF05957.13 EEA07383.1 - 0.91 10.2 3.9 3 8.5 3.9 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) BST2 PF16716.5 EEA07383.1 - 1.2 9.8 17.4 3.9 8.1 0.1 3.1 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Allexi_40kDa PF05549.11 EEA07383.1 - 1.4 8.4 7.9 1.6 8.2 7.4 1.3 1 1 0 1 1 1 0 Allexivirus 40kDa protein THOC7 PF05615.13 EEA07383.1 - 1.8 8.8 13.9 1.4 9.2 7.3 2.5 1 1 1 2 2 2 0 Tho complex subunit 7 FlaC_arch PF05377.11 EEA07383.1 - 1.9 9.0 18.0 18 5.8 4.5 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Fzo_mitofusin PF04799.13 EEA07383.1 - 1.9 8.0 9.7 2 8.0 8.2 1.8 1 1 1 2 2 2 0 fzo-like conserved region LMBR1 PF04791.16 EEA07383.1 - 2 7.2 4.4 2 7.2 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Perilipin PF03036.16 EEA07383.1 - 2.1 7.3 9.8 3.5 6.5 9.3 1.6 1 1 1 2 2 2 0 Perilipin family YPEB PF14620.6 EEA07383.1 - 2.5 7.3 10.7 8.5 5.6 9.9 1.9 1 1 1 2 2 2 0 YpeB sporulation FemAB PF02388.16 EEA07383.1 - 2.6 6.8 8.7 3.8 6.3 8.7 1.2 1 0 0 1 1 1 0 FemAB family Occludin_ELL PF07303.13 EEA07383.1 - 3.2 8.5 9.0 7 7.4 7.8 2.2 1 1 0 1 1 1 0 Occludin homology domain DUF745 PF05335.13 EEA07383.1 - 3.9 7.2 7.1 3 7.5 5.3 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) PspB PF06667.12 EEA07383.1 - 7.5 6.7 9.0 18 5.4 2.6 3.1 2 1 1 3 3 3 0 Phage shock protein B ABC_tran_Xtn PF12848.7 EEA07383.1 - 8.8 6.4 10.6 2.2 8.4 6.2 2.1 1 1 0 2 2 2 0 ABC transporter DSS1_SEM1 PF05160.13 EEA07384.1 - 0.00044 20.3 26.0 0.02 14.9 26.0 2.3 1 1 0 1 1 1 1 DSS1/SEM1 family Ribosomal_S19e PF01090.19 EEA07385.1 - 2.5e-50 169.7 0.0 2.9e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e ubiquitin PF00240.23 EEA07386.1 - 5.4e-05 22.9 0.2 0.044 13.5 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin family Ubiquitin_2 PF14560.6 EEA07386.1 - 0.0035 17.7 0.1 0.012 16.1 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Pro_isomerase PF00160.21 EEA07387.1 - 3.4e-41 141.2 0.3 4.1e-41 140.9 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DEAD PF00270.29 EEA07388.1 - 6.1e-45 153.1 0.0 1.5e-44 151.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA07388.1 - 3.7e-30 104.5 1.0 1.3e-29 102.7 0.2 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA07388.1 - 1.4e-05 25.2 0.0 2.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EEA07388.1 - 0.00011 21.9 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 EEA07388.1 - 0.00079 18.8 0.0 0.0017 17.7 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 EEA07388.1 - 0.011 16.0 0.3 0.037 14.3 0.0 2.0 2 1 0 2 2 2 0 AAA domain CDC37_C PF08564.10 EEA07388.1 - 0.035 14.2 0.0 5 7.3 0.0 2.5 2 0 0 2 2 2 0 Cdc37 C terminal domain AAA_22 PF13401.6 EEA07388.1 - 0.051 13.9 1.2 5.2 7.3 0.4 3.0 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 EEA07389.1 - 2.2e-31 109.2 0.0 3.4e-22 79.1 0.0 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07389.1 - 7.6e-15 54.9 0.0 5.2e-12 45.6 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase FTA2 PF13095.6 EEA07389.1 - 0.0042 16.8 0.0 0.67 9.5 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 PQQ PF01011.21 EEA07389.1 - 0.0085 16.0 1.0 9.5 6.4 0.1 3.6 3 0 0 3 3 3 1 PQQ enzyme repeat Kdo PF06293.14 EEA07389.1 - 0.0097 15.3 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-A20 PF01754.16 EEA07390.1 - 7.4e-11 41.8 10.5 7.4e-11 41.8 10.5 2.3 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.16 EEA07390.1 - 5.3e-10 39.3 9.2 5.3e-10 39.3 9.2 2.1 2 0 0 2 2 2 1 AN1-like Zinc finger DUF4428 PF14471.6 EEA07390.1 - 0.91 9.5 10.6 3.8 7.5 2.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) Actin PF00022.19 EEA07391.1 - 9.7e-88 294.5 0.0 2e-86 290.2 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA07391.1 - 0.0074 15.1 0.0 2.2 7.0 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein LRR_9 PF14580.6 EEA07392.1 - 2.8e-14 53.0 1.9 7.7e-14 51.6 1.9 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EEA07392.1 - 2.7e-10 40.4 9.8 0.00022 21.5 2.2 3.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EEA07392.1 - 2.9e-07 30.1 11.0 0.00037 20.2 0.9 3.2 1 1 0 2 2 2 2 Leucine rich repeat BUD22 PF09073.10 EEA07392.1 - 0.021 14.2 34.5 0.027 13.8 34.5 1.2 1 0 0 1 1 1 0 BUD22 Hid1 PF12722.7 EEA07392.1 - 0.47 8.5 9.1 0.58 8.2 9.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LRR_6 PF13516.6 EEA07392.1 - 0.69 10.1 4.1 5.1 7.4 0.2 3.8 4 0 0 4 4 4 0 Leucine Rich repeat SDA1 PF05285.12 EEA07392.1 - 1.4 8.3 43.6 2.4 7.5 43.6 1.4 1 0 0 1 1 1 0 SDA1 SURF2 PF05477.11 EEA07392.1 - 4.1 7.0 26.3 6.8 6.3 26.3 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Dynactin_p62 PF05502.13 EEA07392.1 - 4.9 5.8 11.5 0.33 9.7 6.5 1.5 1 1 1 2 2 2 0 Dynactin p62 family SAPS PF04499.15 EEA07392.1 - 8.2 5.1 14.7 11 4.7 14.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ank_2 PF12796.7 EEA07394.1 - 0.038 14.6 0.1 0.098 13.3 0.1 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) zf-RING_5 PF14634.6 EEA07395.1 - 4.6 7.3 21.6 0.031 14.2 11.8 2.6 3 1 0 3 3 3 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA07396.1 - 0.18 11.7 12.5 0.41 10.5 11.9 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 FtsH_ext PF06480.15 EEA07396.1 - 0.24 11.8 6.1 0.57 10.6 6.1 1.7 1 0 0 1 1 1 0 FtsH Extracellular zf-RING_2 PF13639.6 EEA07396.1 - 0.4 11.1 15.0 0.89 9.9 15.0 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EEA07396.1 - 0.57 10.2 16.3 1.3 9.0 16.3 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-MIZ PF02891.20 EEA07396.1 - 1.2 9.0 13.1 2.9 7.7 13.1 1.8 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.25 EEA07396.1 - 6.2 6.8 15.8 18 5.3 15.8 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ABC_tran PF00005.27 EEA07397.1 - 3.1e-35 121.7 0.0 8.3e-18 65.2 0.0 2.3 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EEA07397.1 - 1.4e-13 50.4 1.7 3.2e-13 49.2 1.7 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 EEA07397.1 - 3.1e-10 40.4 6.0 0.0034 17.2 0.0 4.2 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA07397.1 - 1.3e-09 37.8 6.8 0.00013 21.4 2.0 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 EEA07397.1 - 9.8e-09 34.7 3.5 9.8e-09 34.7 3.5 2.5 2 0 0 2 2 1 1 4Fe-4S binding domain AAA_15 PF13175.6 EEA07397.1 - 2e-08 34.3 5.0 0.00013 21.8 1.6 3.1 2 1 0 3 3 3 2 AAA ATPase domain Rad17 PF03215.15 EEA07397.1 - 2.7e-06 27.4 0.0 0.1 12.5 0.0 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain Fer4_6 PF12837.7 EEA07397.1 - 3.1e-06 27.0 2.9 3.1e-06 27.0 2.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 EEA07397.1 - 2.9e-05 24.0 0.0 0.12 12.2 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EEA07397.1 - 3.3e-05 23.6 0.1 0.32 10.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_7 PF12838.7 EEA07397.1 - 4.4e-05 24.0 5.3 0.00014 22.4 0.3 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_23 PF13476.6 EEA07397.1 - 7.7e-05 23.3 0.7 0.016 15.7 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA PF00004.29 EEA07397.1 - 8.5e-05 23.0 0.4 0.64 10.4 0.1 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EEA07397.1 - 0.00023 21.1 0.1 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EEA07397.1 - 0.00037 20.8 0.5 0.58 10.6 0.0 3.3 3 0 0 3 3 3 1 RNA helicase SRP54 PF00448.22 EEA07397.1 - 0.0015 18.2 0.4 0.18 11.4 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_21 PF14697.6 EEA07397.1 - 0.0016 18.5 13.4 0.003 17.6 13.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EEA07397.1 - 0.0024 17.9 1.6 0.0024 17.9 1.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_5 PF07728.14 EEA07397.1 - 0.0028 17.7 0.0 0.35 10.8 0.0 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) Fer4_2 PF12797.7 EEA07397.1 - 0.0029 17.6 1.5 0.0029 17.6 1.5 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_9 PF13187.6 EEA07397.1 - 0.0037 17.4 11.9 0.0073 16.5 11.9 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_18 PF13238.6 EEA07397.1 - 0.004 17.7 0.1 1.5 9.4 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 EEA07397.1 - 0.0053 17.2 0.0 3.1 8.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Fer4_16 PF13484.6 EEA07397.1 - 0.0056 17.6 4.4 0.0061 17.5 0.2 2.5 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain AAA_14 PF13173.6 EEA07397.1 - 0.0059 16.6 0.9 0.52 10.4 0.0 3.2 2 1 1 3 3 3 1 AAA domain PduV-EutP PF10662.9 EEA07397.1 - 0.0091 15.7 0.4 0.094 12.5 0.0 2.6 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EEA07397.1 - 0.014 15.7 0.0 2.1 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EEA07397.1 - 0.016 15.4 0.0 5.2 7.4 0.0 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 EEA07397.1 - 0.017 14.4 0.0 0.25 10.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin NB-ARC PF00931.22 EEA07397.1 - 0.022 14.0 0.6 11 5.1 0.1 3.0 3 0 0 3 3 3 0 NB-ARC domain AAA_33 PF13671.6 EEA07397.1 - 0.023 14.8 0.0 2.3 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EEA07397.1 - 0.027 14.4 0.1 0.057 13.3 0.1 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea G-alpha PF00503.20 EEA07397.1 - 0.028 13.6 0.5 0.15 11.2 0.1 2.4 2 2 0 2 2 2 0 G-protein alpha subunit TsaE PF02367.17 EEA07397.1 - 0.032 14.2 0.0 0.48 10.4 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EEA07397.1 - 0.034 14.4 0.0 4.7 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EEA07397.1 - 0.039 13.7 0.2 3.2 7.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fer4_8 PF13183.6 EEA07397.1 - 0.067 13.6 4.6 0.09 13.2 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain VirE PF05272.11 EEA07397.1 - 0.16 11.7 0.0 8.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_30 PF13604.6 EEA07397.1 - 0.17 11.6 0.0 8.1 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EEA07397.1 - 0.17 11.4 1.5 11 5.6 0.0 3.4 4 0 0 4 4 4 0 Ferrous iron transport protein B NTPase_1 PF03266.15 EEA07397.1 - 0.2 11.6 2.7 17 5.3 0.0 4.1 6 0 0 6 6 4 0 NTPase MeaB PF03308.16 EEA07397.1 - 0.23 10.4 0.2 1.3 7.9 0.1 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EEA07397.1 - 0.34 11.0 1.8 26 4.9 0.2 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase Fer4_17 PF13534.6 EEA07397.1 - 6.3 7.4 12.4 77 3.9 12.6 2.3 1 1 1 2 2 1 0 4Fe-4S dicluster domain PNTB PF02233.16 EEA07398.1 - 9.6e-160 532.5 24.2 4.5e-159 530.2 16.3 2.2 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EEA07398.1 - 8.8e-54 182.0 0.0 2.3e-53 180.7 0.0 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain PNTB_4TM PF12769.7 EEA07398.1 - 5.6e-27 94.0 4.7 5.6e-27 94.0 4.7 4.4 4 2 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch AlaDh_PNT_N PF05222.15 EEA07398.1 - 3.4e-19 69.5 0.0 6.9e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 EEA07398.1 - 1.3e-06 27.8 0.3 0.00041 19.8 0.1 3.0 2 1 1 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EEA07398.1 - 0.045 13.0 1.5 0.081 12.1 1.5 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EEA07398.1 - 0.052 13.5 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase DUF3270 PF11674.8 EEA07398.1 - 1.4 9.2 5.8 0.22 11.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) Tcp10_C PF07202.13 EEA07399.1 - 0.003 17.5 1.8 0.036 14.0 0.1 2.2 2 0 0 2 2 2 1 T-complex protein 10 C-terminus Filament PF00038.21 EEA07399.1 - 0.097 12.2 15.3 0.012 15.3 6.6 2.1 1 1 0 2 2 2 0 Intermediate filament protein PID PF00640.23 EEA07399.1 - 0.3 11.1 3.7 0.3 11.1 0.8 2.0 1 1 1 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Lebercilin PF15619.6 EEA07399.1 - 0.44 10.2 14.2 0.23 11.1 5.0 3.0 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF745 PF05335.13 EEA07399.1 - 1.2 8.8 10.1 0.39 10.4 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Prefoldin PF02996.17 EEA07399.1 - 1.2 9.0 15.7 3.7 7.5 2.8 3.6 2 1 1 3 3 3 0 Prefoldin subunit DUF4472 PF14739.6 EEA07399.1 - 2.4 9.0 13.8 0.58 10.9 4.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) Ydr279_N PF17745.1 EEA07401.1 - 0.0016 18.7 0.6 0.033 14.5 0.0 2.6 2 1 0 2 2 2 1 Ydr279p protein triple barrel domain DUF2408 PF10303.9 EEA07402.1 - 2 9.0 8.9 1.1 9.9 2.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2408) TB2_DP1_HVA22 PF03134.19 EEA07403.1 - 6.9e-17 61.2 4.8 6.9e-17 61.2 4.8 1.4 1 1 0 1 1 1 1 TB2/DP1, HVA22 family DUF4538 PF15061.6 EEA07405.1 - 0.37 10.5 1.8 5.2 6.9 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4538) DUF3192 PF11399.8 EEA07405.1 - 0.68 9.9 5.3 6.5 6.8 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3192) RRM_1 PF00076.22 EEA07406.1 - 3.9e-17 61.8 0.0 6.1e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA07406.1 - 0.044 13.9 0.0 0.1 12.8 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif Abhydrolase_1 PF00561.20 EEA07407.1 - 2.3e-09 37.3 0.4 6.7e-06 25.9 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA07407.1 - 3.4e-09 36.3 0.2 7.2e-07 28.7 0.2 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EEA07407.1 - 4.6e-05 23.0 0.1 0.033 13.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.11 EEA07407.1 - 0.00026 21.0 0.0 0.00045 20.2 0.0 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EEA07407.1 - 0.00091 18.9 0.4 0.0061 16.2 0.4 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Palm_thioest PF02089.15 EEA07407.1 - 0.003 17.4 0.2 0.98 9.2 0.0 2.1 1 1 1 2 2 2 2 Palmitoyl protein thioesterase Abhydrolase_2 PF02230.16 EEA07407.1 - 0.008 16.0 1.5 1.1 9.0 0.1 2.7 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase UPF0227 PF05728.12 EEA07407.1 - 0.0082 16.1 0.2 0.03 14.3 0.2 1.9 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) DUF3530 PF12048.8 EEA07407.1 - 0.034 13.6 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Abhydrolase_5 PF12695.7 EEA07407.1 - 0.039 13.7 0.1 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family DLH PF01738.18 EEA07407.1 - 0.098 12.2 0.0 1.2 8.7 0.0 2.3 2 1 0 2 2 2 0 Dienelactone hydrolase family VPS9 PF02204.18 EEA07408.1 - 0.024 14.8 0.2 0.19 11.9 0.0 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain Transket_pyr PF02779.24 EEA07409.1 - 1.8e-46 158.1 0.0 2.8e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EEA07409.1 - 1e-40 138.9 0.0 1.8e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EEA07409.1 - 7.7e-38 130.1 0.0 2.4e-37 128.5 0.0 1.7 1 1 0 1 1 1 1 Dehydrogenase E1 component Peptidase_S15 PF02129.18 EEA07410.1 - 1.7e-29 103.2 0.6 8.6e-26 91.1 0.2 2.3 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EEA07410.1 - 1.2e-11 45.1 0.0 3.3e-11 43.6 0.0 1.7 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 EEA07410.1 - 0.0021 17.4 0.0 0.0047 16.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EEA07410.1 - 0.0081 15.6 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PSS PF03034.15 EEA07411.1 - 1.6e-98 329.8 15.9 3.2e-98 328.8 15.9 1.5 1 0 0 1 1 1 1 Phosphatidyl serine synthase ENTH PF01417.20 EEA07412.1 - 7.7e-12 45.4 0.1 4.7e-09 36.3 0.0 2.7 2 0 0 2 2 2 2 ENTH domain IL7 PF01415.16 EEA07412.1 - 7.6 6.6 8.8 0.51 10.4 1.6 2.7 3 1 0 3 3 3 0 Interleukin 7/9 family SF-assemblin PF06705.11 EEA07413.1 - 6.8e-10 38.7 16.8 9.1e-09 35.0 2.8 2.8 1 1 2 3 3 3 2 SF-assemblin/beta giardin YgaB PF14182.6 EEA07413.1 - 0.0018 18.6 14.7 0.098 13.1 0.6 3.8 3 2 1 4 4 4 2 YgaB-like protein NSP2_assoc PF14758.6 EEA07413.1 - 0.0066 16.8 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 Non-essential region of nsp2 of arterivirus polyprotein CheZ PF04344.13 EEA07413.1 - 0.14 12.0 3.3 0.16 11.9 0.4 2.2 1 1 1 2 2 2 0 Chemotaxis phosphatase, CheZ FAM25 PF15825.5 EEA07413.1 - 0.16 12.3 1.5 7 7.1 0.0 2.8 3 0 0 3 3 3 0 FAM25 family IFT57 PF10498.9 EEA07413.1 - 0.26 10.2 13.6 0.22 10.4 9.9 2.3 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 DASH_Dam1 PF08653.10 EEA07413.1 - 0.26 11.1 6.2 1.1 9.2 1.5 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 Casc1_N PF15927.5 EEA07413.1 - 0.91 9.2 5.4 0.39 10.4 0.4 2.4 1 1 1 2 2 2 0 Cancer susceptibility candidate 1 N-terminus DRE2_N PF16803.5 EEA07413.1 - 1 9.6 4.3 1.2 9.3 1.7 2.3 2 1 0 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus CREPT PF16566.5 EEA07413.1 - 1.2 9.3 5.5 3.2 7.9 0.1 3.0 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour MOLO1 PF17175.4 EEA07413.1 - 1.6 8.9 9.3 0.72 10.0 1.7 2.7 1 1 2 3 3 3 0 Modulator of levamisole receptor-1 Spectrin PF00435.21 EEA07413.1 - 1.8 9.1 6.3 0.84 10.2 0.2 2.7 3 1 0 3 3 3 0 Spectrin repeat Cauli_DNA-bind PF03310.13 EEA07413.1 - 2.2 8.4 12.3 0.16 12.0 3.2 2.7 1 1 2 3 3 3 0 Caulimovirus DNA-binding protein ACBP PF00887.19 EEA07414.1 - 1.6e-19 69.9 0.1 2.6e-19 69.2 0.1 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_4 PF13637.6 EEA07414.1 - 2.1e-16 60.0 0.1 2e-13 50.5 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA07414.1 - 1.5e-13 50.6 0.1 2.3e-08 34.2 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EEA07414.1 - 1.1e-12 48.3 0.0 4.6e-06 27.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EEA07414.1 - 3.3e-11 43.1 0.0 1.7e-05 25.0 0.0 3.3 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EEA07414.1 - 1.9e-07 30.8 1.9 0.0082 16.6 0.0 3.8 4 1 1 5 5 5 2 Ankyrin repeat DUF3686 PF12458.8 EEA07414.1 - 0.15 10.6 0.1 2.4 6.6 0.0 2.0 1 1 1 2 2 2 0 ATPase involved in DNA repair Peptidase_C12 PF01088.21 EEA07417.1 - 1.3e-51 175.4 0.0 1.8e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EEA07417.1 - 7e-13 48.2 0.8 1.3e-12 47.4 0.8 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases SNF2_N PF00176.23 EEA07418.1 - 1.8e-53 181.5 0.0 3.7e-53 180.5 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA07418.1 - 6.1e-14 52.3 0.0 1.9e-13 50.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA07418.1 - 2.1e-09 37.6 0.0 5.5e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA07418.1 - 0.00064 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EEA07418.1 - 0.014 14.7 0.0 0.04 13.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SWI2_SNF2 PF18766.1 EEA07418.1 - 0.024 14.3 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase HDA2-3 PF11496.8 EEA07418.1 - 0.042 13.0 0.0 0.28 10.3 0.0 2.3 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Importin_rep_6 PF18829.1 EEA07418.1 - 0.11 12.6 2.9 0.29 11.3 2.9 1.6 1 0 0 1 1 1 0 Importin repeat 6 DDE_1 PF03184.19 EEA07419.1 - 0.00066 19.4 0.1 0.0016 18.1 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase PF00069.25 EEA07421.1 - 3e-54 184.1 11.4 6.2e-50 170.0 1.1 4.2 4 1 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07421.1 - 1e-24 87.3 0.2 6.9e-18 64.9 0.2 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA07421.1 - 5.2e-05 22.7 0.0 0.0032 16.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EEA07421.1 - 0.00012 21.2 0.1 0.00012 21.2 0.1 2.3 3 0 0 3 3 3 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EEA07421.1 - 0.0006 18.7 4.8 0.0006 18.7 4.8 2.3 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EEA07421.1 - 0.0011 18.1 10.2 0.0011 18.1 10.2 2.5 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EEA07421.1 - 0.0016 18.4 0.9 0.0084 16.0 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA07421.1 - 0.02 14.2 0.1 0.035 13.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EEA07421.1 - 0.021 14.4 2.2 0.026 14.1 0.9 1.8 2 0 0 2 2 2 0 RIO1 family CRAL_TRIO PF00650.20 EEA07423.1 - 2e-30 105.6 0.0 3.2e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EEA07423.1 - 4.5e-06 26.9 0.1 2e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Sigma70_ner PF04546.13 EEA07423.1 - 0.16 11.8 0.5 0.29 11.0 0.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF1694 PF07997.11 EEA07425.1 - 0.062 13.4 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) Peptidase_C97 PF05903.14 EEA07426.1 - 1e-40 139.0 0.0 1.7e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUB PF09409.10 EEA07426.1 - 5.1e-15 55.2 4.7 1.2e-14 54.0 0.3 2.7 2 1 1 3 3 3 1 PUB domain UBA PF00627.31 EEA07426.1 - 0.00038 20.3 0.0 0.00086 19.2 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain HOIP-UBA PF16678.5 EEA07426.1 - 0.0013 18.7 0.2 0.0064 16.5 0.0 2.2 3 0 0 3 3 3 1 HOIP UBA domain pair UBA_5 PF16577.5 EEA07426.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 UBA domain Baculo_PEP_C PF04513.12 EEA07426.1 - 0.94 9.5 5.8 1.5 8.8 3.7 2.3 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus KH_1 PF00013.29 EEA07427.1 - 1.4e-25 88.8 0.1 7.7e-07 28.9 0.1 4.5 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 EEA07427.1 - 3.2e-07 30.1 0.1 0.0068 16.3 0.0 4.2 4 0 0 4 4 4 2 KH domain KH_2 PF07650.17 EEA07427.1 - 7.5e-05 22.5 0.8 5.1 7.0 0.0 4.1 3 1 0 4 4 4 2 KH domain DUF2969 PF11184.8 EEA07427.1 - 0.012 16.0 0.2 1.3 9.5 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2969) DeoC PF01791.9 EEA07428.1 - 0.082 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 DeoC/LacD family aldolase Glyco_transf_41 PF13844.6 EEA07429.1 - 2.1e-41 141.9 3.6 1.1e-23 83.4 0.2 2.8 3 1 0 3 3 3 2 Glycosyl transferase family 41 TPR_2 PF07719.17 EEA07429.1 - 1.5e-22 77.8 0.4 1.6e-05 24.7 0.0 5.9 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA07429.1 - 2.9e-22 77.5 4.6 2e-05 24.2 0.3 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EEA07429.1 - 4.9e-20 70.0 6.1 4.3e-05 23.4 0.0 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 EEA07429.1 - 7.1e-17 60.5 10.8 0.0017 18.6 0.2 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EEA07429.1 - 1.3e-13 50.4 3.4 4.9e-08 32.5 0.2 4.3 1 1 3 4 4 4 4 TPR repeat TPR_12 PF13424.6 EEA07429.1 - 1.9e-13 50.5 0.3 0.002 18.3 0.0 4.6 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EEA07429.1 - 2.4e-13 49.1 1.0 0.0066 16.4 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 EEA07429.1 - 2.5e-11 43.0 1.3 0.034 14.0 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA07429.1 - 2e-05 25.0 0.0 0.083 13.7 0.0 4.1 3 2 2 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EEA07429.1 - 0.00011 22.2 0.0 0.0011 19.1 0.0 2.6 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EEA07429.1 - 0.0004 20.8 0.0 0.035 14.6 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EEA07429.1 - 0.0049 17.4 0.0 2.1 9.2 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EEA07429.1 - 0.042 13.1 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA07429.1 - 0.071 13.8 0.0 0.48 11.1 0.0 2.3 1 1 3 4 4 4 0 Tetratricopeptide repeat partial_CstF PF15861.5 EEA07430.1 - 2.3e-22 78.5 0.3 2.3e-22 78.5 0.3 2.3 3 0 0 3 3 3 1 Partial cleavage stimulation factor domain RRM_1 PF00076.22 EEA07430.1 - 7.9e-19 67.3 0.0 1.3e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 EEA07430.1 - 3.5e-13 49.8 2.4 4.9e-13 49.3 0.5 2.2 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 DUF775 PF05603.12 EEA07431.1 - 0.0041 16.7 3.4 0.0041 16.7 3.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF775) Ist1 PF03398.14 EEA07431.1 - 0.0097 15.8 3.6 0.0097 15.8 3.6 1.6 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway PqqD PF05402.12 EEA07431.1 - 0.09 13.1 0.3 1.3 9.4 0.1 2.4 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) HU-CCDC81_bac_2 PF18175.1 EEA07431.1 - 0.32 10.9 2.2 2.5 8.1 0.5 2.8 2 1 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Pup PF05639.11 EEA07431.1 - 5.3 8.0 6.4 6.5 7.7 2.6 2.7 2 2 1 3 3 3 0 Pup-like protein SNF2_N PF00176.23 EEA07433.1 - 3.2e-50 170.8 1.7 5.5e-50 170.1 0.3 2.1 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA07433.1 - 9.7e-17 61.3 2.7 3.6e-16 59.5 0.2 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA07433.1 - 2.1e-13 50.7 0.0 2.1e-13 50.7 0.0 3.7 3 1 2 5 5 5 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA07433.1 - 1.5e-06 28.1 0.0 5e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase ABC_tran PF00005.27 EEA07435.1 - 9.8e-32 110.3 0.0 3.3e-31 108.6 0.0 1.9 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EEA07435.1 - 3.1e-29 102.5 16.6 4.3e-29 102.0 16.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 EEA07435.1 - 8.2e-05 22.6 0.4 0.23 11.3 0.0 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA07435.1 - 0.00065 19.2 0.1 0.01 15.3 0.0 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain G-alpha PF00503.20 EEA07435.1 - 0.0038 16.5 0.3 0.0038 16.5 0.3 1.9 3 0 0 3 3 3 1 G-protein alpha subunit AAA_16 PF13191.6 EEA07435.1 - 0.0095 16.3 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EEA07435.1 - 0.016 15.2 1.2 0.051 13.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 EEA07435.1 - 0.034 14.2 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PRK PF00485.18 EEA07435.1 - 0.052 13.3 0.0 0.15 11.8 0.0 1.8 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EEA07435.1 - 0.069 13.7 0.0 0.22 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EEA07435.1 - 0.071 12.8 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 EEA07435.1 - 0.093 12.4 0.0 0.35 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EEA07435.1 - 0.11 12.8 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EEA07435.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2439 PF10382.9 EEA07436.1 - 7.2e-14 51.9 1.0 7.2e-14 51.9 1.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) EF-hand_7 PF13499.6 EEA07437.1 - 3.6e-23 81.8 3.7 9.7e-13 48.4 0.8 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EEA07437.1 - 3.8e-23 79.3 8.0 2.4e-06 26.7 0.0 4.5 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EEA07437.1 - 6.9e-21 72.3 3.2 4.1e-05 23.2 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EEA07437.1 - 2.6e-19 67.7 3.6 1.4e-05 24.4 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EEA07437.1 - 2.4e-09 36.9 6.1 0.0093 15.8 0.1 4.4 3 1 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA07437.1 - 2.9e-09 37.2 0.4 0.00046 20.5 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EEA07437.1 - 0.0022 18.3 0.1 0.8 10.1 0.1 3.0 2 1 1 3 3 3 1 EF-hand domain Dockerin_1 PF00404.18 EEA07437.1 - 0.0034 17.6 0.8 0.13 12.5 0.2 3.4 3 1 0 3 3 3 1 Dockerin type I domain EF-hand_4 PF12763.7 EEA07437.1 - 0.016 15.1 4.0 1.8 8.6 0.0 3.2 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand RST PF12174.8 EEA07437.1 - 0.035 14.0 0.0 0.096 12.6 0.0 1.8 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Caleosin PF05042.13 EEA07437.1 - 0.07 13.1 0.9 4.3 7.2 0.0 3.0 2 1 2 4 4 4 0 Caleosin related protein DHHC PF01529.20 EEA07438.1 - 3.3e-35 121.1 13.4 3.3e-35 121.1 13.4 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF4728 PF15860.5 EEA07438.1 - 6.1 7.6 14.8 0.33 11.7 1.6 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4728) PH PF00169.29 EEA07442.1 - 2.7e-06 27.8 0.9 3.8e-06 27.4 0.4 1.6 1 1 0 1 1 1 1 PH domain PH_10 PF15411.6 EEA07442.1 - 0.045 14.0 1.7 0.069 13.4 1.7 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain Mre11_DNA_bind PF04152.14 EEA07443.1 - 6.5e-34 117.7 1.8 3.4e-33 115.3 0.0 2.2 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EEA07443.1 - 9.3e-18 65.5 0.2 1.9e-17 64.5 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA07443.1 - 2e-07 31.3 0.0 4.6e-06 26.9 0.0 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2653 PF10850.8 EEA07444.1 - 0.055 13.7 0.1 0.27 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2653) DUF5082 PF16888.5 EEA07445.1 - 0.25 11.6 13.1 2.1 8.7 0.2 4.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) AKAP2_C PF15304.6 EEA07446.1 - 0.021 14.2 0.2 0.041 13.2 0.2 1.5 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus E1-E2_ATPase PF00122.20 EEA07448.1 - 2.3 7.7 6.2 1.3 8.5 4.1 1.6 2 0 0 2 2 2 0 E1-E2 ATPase Pkinase PF00069.25 EEA07449.1 - 3e-61 207.1 0.1 5.9e-61 206.1 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07449.1 - 1.6e-43 148.9 0.0 2.7e-43 148.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EEA07449.1 - 0.00041 19.2 0.8 0.0035 16.2 0.0 2.2 1 1 0 2 2 2 1 Fungal protein kinase DUF3673 PF12425.8 EEA07449.1 - 0.13 12.2 0.2 8.2 6.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3673) Hormone_3 PF00159.18 EEA07449.1 - 0.63 10.2 3.3 12 6.1 0.0 2.9 2 0 0 2 2 2 0 Pancreatic hormone peptide Phos_pyr_kin PF08543.12 EEA07450.1 - 0.00043 19.8 0.0 0.0016 17.9 0.0 1.9 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Laminin_G_3 PF13385.6 EEA07453.1 - 8e-12 45.6 1.1 1.5e-05 25.2 0.0 3.9 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily Ephrin_rec_like PF07699.13 EEA07453.1 - 0.00025 20.7 5.2 0.00025 20.7 5.2 4.4 3 1 1 4 4 4 2 Putative ephrin-receptor like FXa_inhibition PF14670.6 EEA07453.1 - 2 8.7 6.4 11 6.4 2.0 2.9 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site PCI PF01399.27 EEA07454.1 - 1.2e-09 38.6 1.2 1.2e-09 38.6 1.2 2.7 2 0 0 2 2 2 1 PCI domain TPR_MalT PF17874.1 EEA07454.1 - 0.026 13.9 0.1 0.04 13.3 0.1 1.2 1 0 0 1 1 1 0 MalT-like TPR region ANAPC4_WD40 PF12894.7 EEA07455.1 - 7e-06 26.2 0.3 0.17 12.2 0.0 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA07455.1 - 1.1e-05 26.0 9.5 0.012 16.4 2.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat PQQ PF01011.21 EEA07455.1 - 0.23 11.5 1.2 1.1e+02 2.9 0.0 3.9 3 0 0 3 3 3 0 PQQ enzyme repeat DUF2009 PF09418.10 EEA07456.1 - 9.2e-185 615.0 4.2 1e-119 400.6 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2009) PseudoU_synth_1 PF01416.20 EEA07456.1 - 0.12 12.9 0.1 0.26 11.7 0.1 1.6 1 1 0 1 1 1 0 tRNA pseudouridine synthase E2F_TDP PF02319.20 EEA07457.1 - 4e-12 46.0 0.2 7.8e-12 45.1 0.2 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EEA07457.1 - 0.066 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB zf-CCCH PF00642.24 EEA07459.1 - 7.3e-09 35.3 3.4 9.4e-09 35.0 2.1 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_2 PF13639.6 EEA07459.1 - 0.00018 21.7 10.6 0.00018 21.7 10.6 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EEA07459.1 - 0.0024 17.7 15.2 0.12 12.2 15.8 2.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EEA07459.1 - 0.0089 15.9 13.1 0.026 14.4 13.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Torus PF16131.5 EEA07459.1 - 0.014 16.0 2.0 0.32 11.7 0.0 2.7 2 0 0 2 2 2 0 Torus domain zf-RING_5 PF14634.6 EEA07459.1 - 0.025 14.5 14.9 0.023 14.7 13.3 1.8 2 0 0 2 2 2 0 zinc-RING finger domain Rad50_zn_hook PF04423.14 EEA07459.1 - 0.047 13.5 0.4 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif FYVE_2 PF02318.16 EEA07459.1 - 0.75 10.0 7.7 1.5 9.0 7.7 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger zf_CCCH_4 PF18345.1 EEA07459.1 - 2.2 8.4 9.3 0.42 10.7 4.1 2.5 2 1 0 2 2 2 0 Zinc finger domain zf-RING_4 PF14570.6 EEA07459.1 - 3.9 7.3 12.5 8.1 6.3 12.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 EEA07459.1 - 9.7 6.2 14.5 27 4.7 14.5 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SHS2_Rpb7-N PF03876.17 EEA07462.1 - 9.7e-05 22.7 0.0 0.00018 21.8 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RPA43_OB PF17875.1 EEA07462.1 - 0.00016 22.2 0.0 0.00026 21.6 0.0 1.3 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I SET_assoc PF11767.8 EEA07463.1 - 0.0036 16.9 0.5 0.051 13.2 0.1 2.4 1 1 1 2 2 2 1 Histone lysine methyltransferase SET associated PLU-1 PF08429.11 EEA07464.1 - 1.6e-24 86.7 66.1 4.3e-18 65.6 18.0 9.9 8 4 1 9 9 9 5 PLU-1-like protein PHD PF00628.29 EEA07464.1 - 1.5e-06 28.0 2.1 5.1e-06 26.3 0.6 2.4 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 EEA07464.1 - 0.0051 16.7 0.3 0.014 15.3 0.3 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 EEA07464.1 - 1.1 9.2 4.3 1.1 9.2 1.1 2.7 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD_4 PF16866.5 EEA07464.1 - 4.7 7.4 6.6 33 4.7 6.6 2.4 1 1 0 1 1 1 0 PHD-finger Ribosomal_L36e PF01158.18 EEA07466.1 - 8.4e-37 125.3 4.7 9.5e-37 125.1 4.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Bystin PF05291.11 EEA07467.1 - 3.6e-101 338.3 6.0 4.9e-101 337.9 6.0 1.1 1 0 0 1 1 1 1 Bystin TFIIF_beta PF02270.15 EEA07467.1 - 0.13 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain Peptidase_M16 PF00675.20 EEA07468.1 - 6.8e-37 126.7 0.0 2.2e-36 125.1 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EEA07468.1 - 5.3e-20 71.9 0.0 1.5e-19 70.4 0.0 1.7 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EEA07468.1 - 2.5e-16 60.2 2.0 2.4e-09 37.4 0.3 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Cnd1 PF12717.7 EEA07468.1 - 2.6 8.1 7.1 1.5 8.8 0.5 3.3 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 PHD PF00628.29 EEA07469.1 - 8.8e-07 28.7 10.7 8.8e-07 28.7 10.7 2.4 2 0 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.6 EEA07469.1 - 0.00073 19.4 6.7 0.00098 19.0 5.0 2.2 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 Dynamin_N PF00350.23 EEA07469.1 - 0.0033 17.5 0.8 0.014 15.5 0.8 2.1 1 0 0 1 1 1 1 Dynamin family DUF3449 PF11931.8 EEA07469.1 - 0.0045 16.8 5.4 0.0045 16.8 5.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) Eapp_C PF10238.9 EEA07469.1 - 0.014 15.5 3.9 0.014 15.5 3.9 3.2 3 0 0 3 3 3 0 E2F-associated phosphoprotein C1_2 PF03107.16 EEA07469.1 - 0.033 14.5 6.1 0.28 11.5 1.4 2.8 2 0 0 2 2 2 0 C1 domain Presenilin PF01080.17 EEA07469.1 - 0.038 12.8 6.8 0.11 11.2 6.8 1.7 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 EEA07469.1 - 0.082 12.0 9.8 0.16 11.1 9.8 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Rsc14 PF08586.10 EEA07469.1 - 0.09 13.6 11.4 0.11 13.4 3.1 3.1 3 0 0 3 3 2 0 RSC complex, Rsc14/Ldb7 subunit zinc_ribbon_12 PF11331.8 EEA07469.1 - 0.11 12.3 1.8 0.36 10.7 0.0 2.7 3 0 0 3 3 3 0 Probable zinc-ribbon domain Tim54 PF11711.8 EEA07469.1 - 0.16 10.8 7.6 0.33 9.7 7.6 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 zinc_ribbon_5 PF13719.6 EEA07469.1 - 0.17 11.6 0.6 0.77 9.6 0.1 2.5 2 0 0 2 2 1 0 zinc-ribbon domain Zip PF02535.22 EEA07469.1 - 0.21 10.8 2.5 0.48 9.6 2.5 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 EEA07469.1 - 0.28 10.2 4.3 0.57 9.2 4.3 1.5 1 0 0 1 1 1 0 CLN3 protein RNA_pol_Rbc25 PF08292.12 EEA07469.1 - 0.33 11.2 7.6 1.2 9.3 7.6 2.0 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 RNA_pol_Rpc4 PF05132.14 EEA07469.1 - 0.45 11.0 7.8 1.3 9.4 7.8 1.8 1 0 0 1 1 1 0 RNA polymerase III RPC4 PHD_2 PF13831.6 EEA07469.1 - 0.55 9.8 17.5 0.018 14.6 6.3 3.0 3 0 0 3 3 3 0 PHD-finger CPSF100_C PF13299.6 EEA07469.1 - 0.57 10.3 10.4 0.27 11.4 7.0 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RP-C_C PF11800.8 EEA07469.1 - 2.4 8.2 9.1 1.5 8.9 5.7 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF3408 PF11888.8 EEA07469.1 - 2.4 8.3 18.5 0.34 11.1 13.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) DUF4175 PF13779.6 EEA07469.1 - 2.8 5.7 13.1 3.8 5.3 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Coilin_N PF15862.5 EEA07469.1 - 3.3 7.5 20.3 0.12 12.2 11.1 2.7 2 0 0 2 2 2 0 Coilin N-terminus EIIBC-GUT_N PF03612.14 EEA07469.1 - 4.3 7.0 9.4 12 5.6 9.4 1.7 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF1682 PF07946.14 EEA07469.1 - 4.7 6.3 16.1 1.4 8.1 12.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) Connexin PF00029.19 EEA07469.1 - 4.7 6.9 10.2 0.33 10.7 4.7 1.8 2 0 0 2 2 1 0 Connexin ATP-synt_E PF05680.12 EEA07469.1 - 5.2 7.5 12.0 11 6.4 10.3 2.3 2 0 0 2 2 2 0 ATP synthase E chain RR_TM4-6 PF06459.12 EEA07469.1 - 5.8 6.7 17.5 0.27 11.0 11.3 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 EEA07469.1 - 9 5.6 19.9 15 4.9 19.9 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT GATA PF00320.27 EEA07470.1 - 4.6e-06 26.1 5.7 4.6e-06 26.1 5.7 4.2 4 0 0 4 4 4 1 GATA zinc finger His_Phos_1 PF00300.22 EEA07471.1 - 3.7e-18 65.9 0.0 6.3e-12 45.6 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF4364 PF14277.6 EEA07471.1 - 0.0082 15.9 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) SpoU_methylase PF00588.19 EEA07472.1 - 8.7e-23 81.1 0.0 1.6e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family BRCC36_C PF18110.1 EEA07472.1 - 0.025 14.7 1.5 0.053 13.7 0.1 2.3 2 0 0 2 2 2 0 BRCC36 C-terminal helical domain Inhibitor_I29 PF08246.12 EEA07472.1 - 2.7 8.5 4.9 3.5 8.1 1.1 2.9 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) Hydrolase_3 PF08282.12 EEA07473.1 - 8.5e-18 65.0 7.0 2.5e-15 56.9 7.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EEA07473.1 - 2.6e-05 23.9 0.0 0.0067 16.0 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EEA07473.1 - 0.019 15.3 0.0 0.058 13.7 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA07473.1 - 0.079 13.4 0.0 3.2 8.1 0.0 2.4 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA07473.1 - 0.32 11.1 3.0 3.1 7.9 0.1 2.6 1 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DDRGK PF09756.9 EEA07474.1 - 1.2e-36 126.1 21.9 1.5e-36 125.7 21.9 1.1 1 0 0 1 1 1 1 DDRGK domain DUF2500 PF10694.9 EEA07474.1 - 1.6 9.3 5.7 9.1 6.8 5.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2500) MAP17 PF15807.5 EEA07474.1 - 4 7.7 10.3 1.2e+02 2.9 10.3 2.4 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF809 PF05663.11 EEA07474.1 - 8.3 6.6 9.6 54 3.9 9.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF809) CDC50 PF03381.15 EEA07476.1 - 1.4e-29 103.5 1.5 2.6e-29 102.6 1.5 1.4 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DbpA PF03880.15 EEA07476.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 DbpA RNA binding domain Rab5ip PF07019.12 EEA07477.1 - 4.8e-08 33.5 6.1 6.5e-08 33.1 6.1 1.2 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF2530 PF10745.9 EEA07477.1 - 0.46 10.7 0.1 0.46 10.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) NPR3 PF03666.13 EEA07478.1 - 0.00032 19.6 8.6 0.0042 15.9 0.3 2.3 1 1 0 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 HTH_IclR PF09339.10 EEA07478.1 - 0.067 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain zf-RING_2 PF13639.6 EEA07479.1 - 9.5e-09 35.5 15.4 1.7e-08 34.6 12.6 2.7 3 0 0 3 3 2 1 Ring finger domain zf-rbx1 PF12678.7 EEA07479.1 - 5.5e-07 29.8 11.4 1.6e-06 28.3 11.4 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EEA07479.1 - 8.3e-06 25.7 10.8 2.1e-05 24.4 10.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA07479.1 - 6.2e-05 22.8 16.5 0.00035 20.3 14.8 3.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA07479.1 - 9.2e-05 22.0 8.7 0.00021 20.8 8.7 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EEA07479.1 - 0.00043 20.0 7.5 0.00043 20.0 7.5 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EEA07479.1 - 0.0011 18.8 11.6 0.0033 17.2 11.6 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA07479.1 - 0.0012 18.7 13.9 0.0036 17.1 13.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA07479.1 - 0.0015 18.5 8.6 0.038 14.0 7.5 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EEA07479.1 - 0.013 15.5 4.3 0.013 15.5 4.3 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EEA07479.1 - 0.042 13.7 10.3 0.1 12.5 10.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_9 PF13901.6 EEA07479.1 - 0.045 13.7 8.5 0.086 12.8 8.5 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon FANCL_C PF11793.8 EEA07479.1 - 0.32 11.2 9.3 0.94 9.7 9.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 EEA07479.1 - 0.39 10.7 10.9 0.87 9.5 10.9 1.6 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 EEA07479.1 - 2.5 8.3 11.7 6 7.1 11.7 1.7 1 0 0 1 1 1 0 RING-variant domain WD40 PF00400.32 EEA07480.1 - 4.8e-25 87.3 8.9 0.0022 18.8 1.4 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07480.1 - 1.1e-07 32.1 0.1 0.022 15.0 0.0 3.6 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA07480.1 - 0.0028 17.6 2.2 0.28 11.1 0.1 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A zf-RING_14 PF17978.1 EEA07480.1 - 0.13 12.7 0.3 1 9.8 0.1 2.5 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain DHHC PF01529.20 EEA07483.1 - 2.5 8.2 9.4 0.58 10.3 5.2 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase TB2_DP1_HVA22 PF03134.19 EEA07484.1 - 8.9e-29 99.3 6.1 8.9e-29 99.3 6.1 1.6 2 0 0 2 2 2 1 TB2/DP1, HVA22 family CAF1A PF12253.8 EEA07485.1 - 4.2e-10 39.7 4.7 1.3e-09 38.1 4.7 1.8 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A G-patch PF01585.23 EEA07486.1 - 3.1e-16 59.0 2.4 4.1e-16 58.6 2.4 1.2 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EEA07486.1 - 0.0018 18.4 0.6 0.0035 17.4 0.6 1.5 1 0 0 1 1 1 1 G-patch domain IF-2B PF01008.17 EEA07487.1 - 2.6e-16 59.7 4.1 1.6e-14 53.8 4.1 2.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Pox_EPC_I2-L1 PF12575.8 EEA07488.1 - 0.022 15.0 0.0 0.058 13.6 0.0 1.7 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Orf78 PF06024.12 EEA07488.1 - 0.093 13.0 3.0 0.11 12.8 0.3 2.4 1 1 1 2 2 2 0 Orf78 (ac78) OrsD PF12013.8 EEA07489.1 - 0.074 13.5 2.8 0.11 13.0 0.2 2.2 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D Longin PF13774.6 EEA07490.1 - 5.2e-20 71.3 0.2 2.1e-19 69.3 0.2 1.9 1 1 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EEA07490.1 - 6e-15 54.8 0.4 9.9e-15 54.1 0.4 1.4 1 0 0 1 1 1 1 Synaptobrevin UPRTase PF14681.6 EEA07491.1 - 1.1e-61 207.9 0.0 1.3e-61 207.7 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EEA07491.1 - 3.4e-06 26.6 0.1 5.8e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DnaJ PF00226.31 EEA07492.1 - 2.3e-09 37.2 0.0 5.4e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain HECT PF00632.25 EEA07493.1 - 5.8e-59 200.1 2.0 1.4e-58 198.8 0.9 2.3 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 EEA07493.1 - 2.8e-06 27.4 0.2 9.6e-06 25.7 0.2 1.9 1 0 0 1 1 1 1 SPRY domain Laminin_G_3 PF13385.6 EEA07493.1 - 0.00023 21.3 1.1 0.2 11.8 0.1 2.9 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily DUF5097 PF17020.5 EEA07493.1 - 0.015 15.6 0.5 0.18 12.1 0.5 3.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) UBA PF00627.31 EEA07493.1 - 0.019 14.9 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain Inositol_P PF00459.25 EEA07494.1 - 1.1e-39 136.6 0.0 1.5e-39 136.2 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family zf-C3HC4 PF00097.25 EEA07495.1 - 4.3e-08 32.9 11.5 7e-08 32.2 11.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA07495.1 - 7.2e-08 32.2 8.1 1.1e-07 31.6 8.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA07495.1 - 3.6e-07 30.0 10.3 5.8e-07 29.4 10.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA07495.1 - 6.6e-07 29.1 11.7 1e-06 28.5 11.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA07495.1 - 1.8e-06 28.2 12.9 2.9e-06 27.5 12.9 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EEA07495.1 - 6.7e-06 25.9 8.3 1.1e-05 25.1 8.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EEA07495.1 - 7.7e-06 25.8 5.9 7.7e-06 25.8 5.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EEA07495.1 - 0.003 17.7 12.2 0.0058 16.8 12.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EEA07495.1 - 0.022 15.0 11.0 0.041 14.2 11.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Baculo_IE-1 PF05290.11 EEA07495.1 - 0.031 14.2 5.9 0.051 13.5 5.9 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Rtf2 PF04641.12 EEA07495.1 - 0.077 12.4 0.4 0.19 11.0 0.4 1.6 1 1 0 1 1 1 0 Rtf2 RING-finger U-box PF04564.15 EEA07495.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 U-box domain Ost4 PF10215.9 EEA07495.1 - 3.4 7.6 8.9 0.75 9.7 2.5 2.2 2 0 0 2 2 2 0 Oligosaccaryltransferase Pkinase PF00069.25 EEA07496.1 - 3.4e-60 203.6 0.1 4e-38 131.3 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07496.1 - 1.7e-27 96.4 0.0 5.1e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EEA07496.1 - 3.6e-09 36.9 0.1 6.8e-05 22.9 0.1 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EEA07496.1 - 0.00016 20.7 0.2 0.00027 20.0 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EEA07496.1 - 0.00035 20.0 0.6 0.0051 16.2 0.0 2.6 2 1 1 3 3 3 1 Kinase-like Seadorna_VP7 PF07387.11 EEA07496.1 - 0.0077 15.3 0.0 0.015 14.4 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EEA07496.1 - 0.0082 15.5 0.1 0.015 14.6 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EEA07496.1 - 0.017 14.7 0.2 0.12 11.9 0.0 2.2 2 1 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 EEA07496.1 - 0.092 12.3 0.2 0.22 11.1 0.2 1.6 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EEA07496.1 - 0.16 11.6 0.7 13 5.4 0.0 2.9 1 1 2 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DUF1654 PF07867.11 EEA07497.1 - 0.06 13.1 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) TPR_1 PF00515.28 EEA07498.1 - 4.6e-41 137.0 21.5 4.5e-08 32.6 0.2 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EEA07498.1 - 4.3e-38 126.4 16.8 3.3e-07 29.9 0.3 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 EEA07498.1 - 1.4e-21 75.9 14.1 1.1e-10 41.0 0.2 5.2 3 2 2 5 5 5 4 TPR repeat TPR_8 PF13181.6 EEA07498.1 - 1.4e-19 68.6 20.1 0.00046 20.2 0.1 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EEA07498.1 - 1.5e-19 70.1 5.0 3.1e-11 43.4 0.1 4.7 3 2 1 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 EEA07498.1 - 1.5e-15 57.4 1.2 0.011 16.2 0.1 4.5 2 2 2 4 4 4 4 Tetratricopeptide repeat STI1 PF17830.1 EEA07498.1 - 2.6e-15 56.1 1.1 9.3e-15 54.3 1.1 2.0 1 0 0 1 1 1 1 STI1 domain TPR_17 PF13431.6 EEA07498.1 - 1.1e-14 53.6 10.9 0.0033 17.7 0.1 6.0 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EEA07498.1 - 2.7e-13 50.3 0.1 1e-05 26.1 0.0 4.0 3 2 1 4 4 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EEA07498.1 - 2.9e-12 46.3 0.3 0.53 11.3 0.0 6.5 5 3 3 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EEA07498.1 - 3.5e-09 36.2 6.2 0.13 12.1 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EEA07498.1 - 1e-08 35.2 0.0 0.047 13.8 0.0 4.3 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EEA07498.1 - 2.1e-08 33.6 6.5 0.0094 15.9 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA07498.1 - 2.3e-06 27.9 11.0 0.38 11.5 0.1 6.3 5 1 1 6 6 6 1 Tetratricopeptide repeat NARP1 PF12569.8 EEA07498.1 - 1.2e-05 24.4 9.5 0.02 13.8 0.0 3.5 1 1 3 4 4 4 2 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 EEA07498.1 - 2e-05 24.4 7.8 0.0055 16.4 2.5 3.8 1 1 1 3 3 3 2 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 EEA07498.1 - 3.8e-05 23.8 9.7 0.051 13.8 2.7 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EEA07498.1 - 0.00094 19.2 17.0 0.68 10.1 0.2 6.2 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat XPC-binding PF09280.11 EEA07498.1 - 0.0015 18.2 1.0 0.0036 17.0 1.0 1.7 1 0 0 1 1 1 1 XPC-binding domain SNAP PF14938.6 EEA07498.1 - 0.0063 16.0 10.8 0.21 10.9 6.0 2.9 1 1 1 3 3 3 1 Soluble NSF attachment protein, SNAP Coatomer_E PF04733.14 EEA07498.1 - 0.015 14.7 5.3 0.87 8.9 1.6 3.7 2 2 1 3 3 3 0 Coatomer epsilon subunit PPR PF01535.20 EEA07498.1 - 0.022 15.0 1.8 0.11 12.9 0.2 2.9 2 0 0 2 2 2 0 PPR repeat DUF3856 PF12968.7 EEA07498.1 - 0.077 13.1 1.3 30 4.7 0.7 3.5 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_MalT PF17874.1 EEA07498.1 - 0.081 12.3 0.1 0.35 10.2 0.0 2.0 2 1 0 2 2 2 0 MalT-like TPR region SHNi-TPR PF10516.9 EEA07498.1 - 0.11 11.9 4.2 0.42 10.1 0.2 3.7 6 0 0 6 6 5 0 SHNi-TPR KapB PF08810.10 EEA07498.1 - 0.9 9.7 4.5 2.1 8.5 0.9 2.7 3 0 0 3 3 2 0 Kinase associated protein B MIT PF04212.18 EEA07498.1 - 0.94 9.6 12.9 22 5.2 0.4 5.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain RabGAP-TBC PF00566.18 EEA07499.1 - 5.3e-14 52.4 20.9 1.3e-13 51.1 4.5 4.6 4 1 1 5 5 5 2 Rab-GTPase-TBC domain WD40 PF00400.32 EEA07500.1 - 2e-48 161.3 30.4 7.6e-09 36.1 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07500.1 - 1.3e-10 41.5 2.5 0.091 13.1 0.4 4.8 2 2 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA07500.1 - 3.8e-06 26.5 0.0 0.12 11.6 0.0 3.1 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 EEA07500.1 - 2.5e-05 23.4 0.1 0.56 9.1 0.1 3.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EEA07500.1 - 0.012 16.1 1.0 2.9 8.5 0.0 3.7 3 1 0 3 3 3 0 PQQ-like domain VID27 PF08553.10 EEA07500.1 - 0.068 12.2 0.0 0.14 11.2 0.0 1.7 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain RAB3GAP2_N PF14655.6 EEA07500.1 - 0.11 11.8 0.0 10 5.3 0.0 2.4 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pkinase PF00069.25 EEA07501.1 - 9.6e-34 116.9 0.0 1.3e-33 116.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07501.1 - 2e-16 60.1 0.0 2.8e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EEA07501.1 - 0.00049 19.5 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA07501.1 - 0.0055 16.7 0.0 0.013 15.5 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family ABC1 PF03109.16 EEA07501.1 - 0.058 13.6 0.0 0.63 10.2 0.0 2.2 2 0 0 2 2 2 0 ABC1 family PT-HINT PF07591.11 EEA07501.1 - 0.086 13.1 0.0 0.22 11.8 0.0 1.6 2 0 0 2 2 2 0 Pretoxin HINT domain SAM_Exu PF18609.1 EEA07502.1 - 0.0056 16.7 0.5 0.0056 16.7 0.5 3.2 2 1 1 3 3 3 1 Exuperantia SAM-like domain Octopine_DH PF02317.17 EEA07502.1 - 0.16 12.1 0.9 0.27 11.3 0.9 1.4 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain ATG16 PF08614.11 EEA07502.1 - 0.27 11.5 31.5 1.2 9.4 29.5 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Myb_DNA-bind_3 PF12776.7 EEA07502.1 - 2.6 9.1 7.4 1.3 10.1 1.7 2.8 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF3450 PF11932.8 EEA07502.1 - 6.9 5.9 23.7 0.12 11.7 7.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) GDP_Man_Dehyd PF16363.5 EEA07503.1 - 2.2e-54 185.1 0.0 2.7e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EEA07503.1 - 8.2e-46 156.4 0.0 9.9e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EEA07503.1 - 6.3e-11 41.8 0.0 4.2e-10 39.1 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EEA07503.1 - 1e-08 34.7 0.1 0.00063 19.0 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EEA07503.1 - 1.8e-07 30.6 0.0 7.2e-06 25.3 0.0 2.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EEA07503.1 - 7.3e-07 28.6 0.0 1.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EEA07503.1 - 0.032 13.7 0.0 0.065 12.7 0.0 1.5 2 0 0 2 2 2 0 short chain dehydrogenase NmrA PF05368.13 EEA07503.1 - 0.051 13.1 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family KR PF08659.10 EEA07503.1 - 0.21 11.5 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 KR domain MORN PF02493.20 EEA07504.1 - 4.5e-47 155.2 73.2 1.3e-07 31.1 0.3 10.3 10 0 0 10 10 10 10 MORN repeat DUF1804 PF08822.11 EEA07505.1 - 0.22 11.5 0.8 19 5.2 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1804) Cupin_2 PF07883.11 EEA07506.1 - 0.002 17.8 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 Cupin domain CENP-C_C PF11699.8 EEA07506.1 - 0.0024 18.1 0.4 0.0038 17.4 0.4 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Ras PF00071.22 EEA07507.1 - 5.2e-58 195.2 0.3 6.9e-58 194.8 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07507.1 - 5.5e-36 123.4 0.1 8.7e-36 122.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA07507.1 - 9.9e-14 51.2 0.3 1.3e-13 50.7 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EEA07507.1 - 2.6e-05 23.9 0.0 0.0001 21.9 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA07507.1 - 5.2e-05 23.3 0.0 8.5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EEA07507.1 - 0.00034 20.1 0.2 0.00077 18.9 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EEA07507.1 - 0.00086 18.7 0.1 0.0013 18.2 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EEA07507.1 - 0.0096 15.8 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EEA07507.1 - 0.023 14.2 0.0 0.067 12.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 EEA07507.1 - 0.027 14.0 0.1 0.47 10.0 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B zf-MIZ PF02891.20 EEA07508.1 - 1.1e-15 57.0 4.1 1.2e-15 57.0 1.3 2.5 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-HC5HC2H PF13771.6 EEA07508.1 - 0.0057 16.9 2.3 0.0057 16.9 2.3 2.5 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD PF00628.29 EEA07508.1 - 0.0092 15.9 3.2 0.0092 15.9 3.2 3.8 4 0 0 4 4 4 1 PHD-finger Zf_RING PF16744.5 EEA07508.1 - 0.18 11.9 1.9 0.5 10.5 1.9 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger PHD_4 PF16866.5 EEA07508.1 - 1.2 9.3 7.2 2.6 8.2 1.6 2.9 2 0 0 2 2 2 0 PHD-finger zf-RING_2 PF13639.6 EEA07508.1 - 2.3 8.6 15.3 4 7.9 3.4 3.6 3 0 0 3 3 3 0 Ring finger domain C1_1 PF00130.22 EEA07508.1 - 3.1 7.8 7.7 0.43 10.5 2.8 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase PF00069.25 EEA07509.1 - 7.8e-67 225.4 0.2 1.8e-66 224.2 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07509.1 - 9.8e-31 107.0 0.3 8.2e-26 90.8 0.4 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA07509.1 - 1.2e-06 28.1 2.0 4.2e-05 23.0 0.1 3.5 3 1 1 4 4 4 1 Kinase-like Kdo PF06293.14 EEA07509.1 - 0.0034 16.8 0.4 0.0061 15.9 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family T2SSB PF16537.5 EEA07510.1 - 0.05 13.2 0.4 0.15 11.7 0.4 1.8 1 0 0 1 1 1 0 Type II secretion system protein B DUF3870 PF12986.7 EEA07510.1 - 0.3 11.3 2.2 2.3 8.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3870) NUMOD3 PF07460.11 EEA07511.1 - 0.14 12.4 0.2 0.4 11.0 0.2 1.8 1 0 0 1 1 1 0 NUMOD3 motif (2 copies) Laminin_I PF06008.14 EEA07512.1 - 0.0028 17.4 2.2 0.0028 17.4 2.2 1.9 2 0 0 2 2 2 1 Laminin Domain I V-SNARE_C PF12352.8 EEA07512.1 - 0.0097 16.2 0.2 0.026 14.8 0.2 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Flavi_capsid PF01003.19 EEA07512.1 - 0.14 11.9 0.2 0.6 9.9 0.0 2.0 2 0 0 2 2 2 0 Flavivirus capsid protein C DUF2408 PF10303.9 EEA07512.1 - 0.3 11.6 6.2 1.5 9.3 6.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) COPI_assoc PF08507.10 EEA07513.1 - 0.00018 21.6 2.1 0.00027 21.0 2.1 1.3 1 0 0 1 1 1 1 COPI associated protein GHMP_kinases_N PF00288.26 EEA07513.1 - 0.048 13.9 1.3 0.45 10.8 0.2 2.4 2 0 0 2 2 2 0 GHMP kinases N terminal domain DUF4231 PF14015.6 EEA07513.1 - 0.82 10.2 3.9 11 6.5 1.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) EF-hand_8 PF13833.6 EEA07514.1 - 5.3e-06 26.2 0.1 1.1e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair COPI_assoc PF08507.10 EEA07514.1 - 2.5e-05 24.3 5.6 9.8e-05 22.4 5.6 1.9 1 1 0 1 1 1 1 COPI associated protein EF-hand_1 PF00036.32 EEA07514.1 - 0.0045 16.4 0.1 0.0089 15.5 0.1 1.5 1 0 0 1 1 1 1 EF hand PrgI PF12666.7 EEA07514.1 - 0.0058 17.3 0.2 0.0058 17.3 0.2 2.4 2 1 0 2 2 2 1 PrgI family protein EF-hand_6 PF13405.6 EEA07514.1 - 0.027 14.4 0.2 0.067 13.2 0.2 1.7 1 0 0 1 1 1 0 EF-hand domain S_4TM PF18159.1 EEA07514.1 - 0.47 9.7 2.3 0.46 9.7 0.1 1.8 1 1 1 2 2 2 0 SMODS-associating 4TM effector domain DUF4383 PF14325.6 EEA07514.1 - 0.76 10.1 7.8 0.19 12.0 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4383) DUF4231 PF14015.6 EEA07514.1 - 1.1 9.8 4.1 8.6 6.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF3228 PF11539.8 EEA07515.1 - 7.2e-81 270.4 0.0 8.3e-81 270.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) DUF4404 PF14357.6 EEA07516.1 - 0.14 12.8 0.0 0.35 11.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF384 PF04064.13 EEA07517.1 - 1.3e-13 50.6 1.0 5.4e-13 48.6 1.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF384) DUF383 PF04063.14 EEA07517.1 - 4.2e-07 29.8 1.4 4.2e-07 29.8 1.4 2.5 1 1 0 2 2 2 1 Domain of unknown function (DUF383) Pico_P2B PF01552.17 EEA07517.1 - 0.098 12.8 2.0 0.21 11.8 0.5 2.2 2 0 0 2 2 2 0 Picornavirus 2B protein Proteasome PF00227.26 EEA07518.1 - 2.4e-53 180.4 0.0 3e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EEA07518.1 - 1.1e-12 47.3 0.1 2.4e-12 46.3 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Tfb2 PF03849.14 EEA07519.1 - 3.1e-40 138.3 10.0 2.7e-25 89.1 0.7 3.0 2 1 0 2 2 2 2 Transcription factor Tfb2 Tfb2_C PF18307.1 EEA07519.1 - 1e-08 35.4 0.6 2.8e-08 34.1 0.3 2.0 2 0 0 2 2 2 1 Transcription factor Tfb2 (p52) C-terminal domain Zds_C PF08632.10 EEA07519.1 - 0.063 13.0 0.1 6.4 6.6 0.0 2.9 2 0 0 2 2 2 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term GTP_EFTU PF00009.27 EEA07520.1 - 5.9e-44 149.9 0.0 1.1e-43 149.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EEA07520.1 - 2e-24 86.1 0.1 7.4e-24 84.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EEA07520.1 - 1.5e-05 25.3 0.0 9e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EEA07520.1 - 0.0025 17.9 0.0 0.016 15.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arm PF00514.23 EEA07521.1 - 0.00035 20.5 0.8 1.1 9.4 0.1 3.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Mo25 PF08569.11 EEA07521.1 - 0.00072 19.0 2.7 0.0013 18.2 2.7 1.4 1 0 0 1 1 1 1 Mo25-like SIL1 PF16782.5 EEA07521.1 - 0.0015 17.8 2.0 0.0024 17.2 2.0 1.4 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Atx10homo_assoc PF09759.9 EEA07521.1 - 0.029 14.4 2.6 0.036 14.1 0.1 2.4 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain RNB PF00773.19 EEA07522.1 - 2.2e-93 313.1 2.9 4.2e-93 312.2 2.9 1.5 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EEA07522.1 - 1.1e-17 63.7 0.0 3.1e-17 62.4 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 EEA07522.1 - 6.1e-07 29.3 1.2 1.7e-06 27.9 1.2 1.8 1 0 0 1 1 1 1 S1 domain CSD2 PF17876.1 EEA07522.1 - 1.5e-05 25.1 0.0 0.0025 17.9 0.0 2.8 2 0 0 2 2 2 1 Cold shock domain OB_RNB PF08206.11 EEA07522.1 - 0.086 12.5 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease B OB domain Spore_III_AB PF09548.10 EEA07523.1 - 0.017 15.3 0.1 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) CobT PF06213.12 EEA07523.1 - 0.068 12.5 0.2 0.086 12.2 0.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MCD_N PF17408.2 EEA07523.1 - 0.11 12.6 0.1 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain HMG_box PF00505.19 EEA07525.1 - 1.3e-22 79.9 5.0 1.3e-22 79.9 5.0 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA07525.1 - 1.6e-16 60.6 6.8 2.3e-16 60.1 6.8 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 EEA07525.1 - 0.00016 21.6 2.4 0.00016 21.6 2.4 1.6 1 1 1 2 2 2 1 HMG (high mobility group) box 5 RXT2_N PF08595.11 EEA07525.1 - 0.0073 16.3 1.0 0.0083 16.2 1.0 1.0 1 0 0 1 1 1 1 RXT2-like, N-terminal CHDNT PF08073.12 EEA07525.1 - 0.011 15.7 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 0 CHDNT (NUC034) domain Hom_end_hint PF05203.16 EEA07525.1 - 0.011 15.7 0.6 0.012 15.5 0.6 1.0 1 0 0 1 1 1 0 Hom_end-associated Hint PFK PF00365.20 EEA07526.1 - 4.7e-61 206.6 0.5 6.2e-37 127.5 0.1 3.4 4 0 0 4 4 4 2 Phosphofructokinase Peptidase_M3 PF01432.20 EEA07527.1 - 2.4e-49 168.9 0.0 6.5e-49 167.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M3 HMG_box PF00505.19 EEA07529.1 - 0.044 14.2 0.3 0.77 10.2 0.0 2.4 2 0 0 2 2 2 0 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA07529.1 - 0.74 10.5 3.7 0.42 11.3 0.8 2.0 2 0 0 2 2 2 0 HMG-box domain EMC1_C PF07774.13 EEA07530.1 - 4e-22 79.0 4.3 4e-22 79.0 4.3 1.8 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ PF01011.21 EEA07530.1 - 0.14 12.1 0.0 0.58 10.2 0.0 2.0 1 0 0 1 1 1 0 PQQ enzyme repeat NGP1NT PF08153.12 EEA07531.1 - 7.3e-34 116.7 0.3 1.9e-33 115.4 0.3 1.8 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EEA07531.1 - 6.4e-17 61.7 0.1 4.9e-14 52.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA07531.1 - 1.2e-05 24.9 0.1 0.0002 20.9 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EEA07531.1 - 5e-05 23.3 0.0 0.00014 21.8 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EEA07531.1 - 0.021 14.3 0.2 1.2 8.6 0.0 2.6 2 0 0 2 2 2 0 ADP-ribosylation factor family Dynamin_N PF00350.23 EEA07531.1 - 0.18 11.8 4.1 1.4 8.9 0.1 3.6 2 2 1 3 3 3 0 Dynamin family DHHC PF01529.20 EEA07533.1 - 1.7e-35 122.0 20.4 1.7e-35 122.0 20.4 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase AA_permease_N PF08403.10 EEA07533.1 - 0.06 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Amino acid permease N-terminal Ribosomal_L37e PF01907.19 EEA07534.1 - 8.9e-24 83.4 15.0 1.5e-23 82.7 15.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e SelR PF01641.18 EEA07534.1 - 0.00098 19.2 0.4 0.0011 19.0 0.4 1.1 1 0 0 1 1 1 1 SelR domain RPN7 PF10602.9 EEA07535.1 - 7.2e-45 152.8 0.9 1.5e-44 151.8 0.9 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EEA07535.1 - 6e-16 58.9 0.3 2.7e-15 56.8 0.1 2.1 2 0 0 2 2 2 1 PCI domain PknG_TPR PF16918.5 EEA07535.1 - 0.092 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat Remorin_C PF03763.13 EEA07535.1 - 2 8.3 9.5 0.26 11.2 0.5 2.8 2 1 0 2 2 2 0 Remorin, C-terminal region PA26 PF04636.13 EEA07537.1 - 8.4e-41 140.3 2.3 3.2e-24 85.7 0.0 2.2 2 0 0 2 2 2 2 PA26 p53-induced protein (sestrin) Rer1 PF03248.13 EEA07539.1 - 1.1e-66 223.8 11.9 1.3e-66 223.6 11.9 1.0 1 0 0 1 1 1 1 Rer1 family YlaH PF14036.6 EEA07539.1 - 0.043 14.1 1.3 0.043 14.1 1.3 2.3 2 1 0 2 2 2 0 YlaH-like protein DUF1980 PF09323.10 EEA07539.1 - 0.056 13.4 0.7 0.14 12.0 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF2208 PF09973.9 EEA07539.1 - 8.2 6.0 12.9 0.16 11.6 6.0 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) DnaJ PF00226.31 EEA07540.1 - 1.8e-15 56.8 3.8 2.8e-15 56.2 1.4 2.7 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 EEA07540.1 - 2.6e-12 46.7 7.6 1e-06 28.8 0.1 3.9 4 0 0 4 4 4 2 Myb-like DNA-binding domain Phage_lysozyme2 PF18013.1 EEA07540.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.9 3 1 1 4 4 4 0 Phage tail lysozyme DXP_reductoisom PF02670.16 EEA07540.1 - 0.36 11.6 2.4 0.96 10.2 2.4 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Flu_NS2 PF00601.19 EEA07540.1 - 0.39 11.0 10.2 0.057 13.7 4.5 2.7 2 1 0 2 2 2 0 Influenza non-structural protein (NS2) OmpH PF03938.14 EEA07540.1 - 1.5 9.1 19.4 5.1 7.4 16.2 2.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Myb_DNA-bind_6 PF13921.6 EEA07540.1 - 8.4 6.7 18.6 0.14 12.4 0.3 4.7 5 0 0 5 5 5 0 Myb-like DNA-binding domain PP2C PF00481.21 EEA07542.1 - 2.9e-16 59.9 0.2 2.9e-16 59.9 0.2 1.8 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 EEA07542.1 - 0.00039 20.1 0.0 0.00077 19.2 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EEA07542.1 - 0.00068 19.6 0.0 0.0045 16.9 0.0 2.1 1 1 1 2 2 2 1 Stage II sporulation protein E (SpoIIE) MAP70 PF07058.11 EEA07542.1 - 0.041 12.6 4.5 0.061 12.1 4.5 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 YabA PF06156.13 EEA07542.1 - 0.097 13.3 0.6 0.27 11.9 0.6 1.8 1 0 0 1 1 1 0 Initiation control protein YabA Cyclin PF08613.11 EEA07543.1 - 8.8e-30 104.2 1.0 1.4e-29 103.5 1.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EEA07543.1 - 4.4e-07 29.7 0.1 1e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain AA_kinase PF00696.28 EEA07544.1 - 7e-42 143.7 1.7 3.1e-41 141.6 0.8 2.0 2 0 0 2 2 2 1 Amino acid kinase family PUA PF01472.20 EEA07544.1 - 2.7e-11 43.3 0.3 7.1e-11 41.9 0.1 1.9 2 0 0 2 2 2 1 PUA domain Pkinase PF00069.25 EEA07545.1 - 2e-35 122.4 0.0 3.1e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07545.1 - 1.1e-25 90.4 0.0 1.6e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EEA07545.1 - 0.00052 20.0 0.1 0.00083 19.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Phosphoesterase PF04185.14 EEA07545.1 - 0.031 13.5 0.1 0.052 12.7 0.1 1.3 1 0 0 1 1 1 0 Phosphoesterase family NOG1 PF06858.14 EEA07545.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) C2 PF00168.30 EEA07546.1 - 1.8e-27 95.6 0.0 1e-05 25.8 0.1 6.2 6 0 0 6 6 6 4 C2 domain Ferlin_C PF16165.5 EEA07546.1 - 0.00061 19.8 0.2 0.019 14.9 0.0 2.5 2 0 0 2 2 2 1 Ferlin C-terminus PPDK_N PF01326.19 EEA07548.1 - 4e-12 46.1 0.1 2.2e-10 40.3 0.1 3.1 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Lipoprotein_16 PF03923.13 EEA07548.1 - 0.024 14.3 0.1 0.048 13.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized lipoprotein MA3 PF02847.17 EEA07549.1 - 6.4e-24 84.1 2.2 3.6e-08 33.4 0.0 4.3 3 1 1 4 4 4 4 MA3 domain Sigma54_CBD PF04963.13 EEA07549.1 - 0.11 12.4 0.5 0.29 10.9 0.1 1.9 2 0 0 2 2 2 0 Sigma-54 factor, core binding domain Dopey_N PF04118.14 EEA07550.1 - 1.3e-90 303.7 1.2 1.3e-90 303.7 1.2 3.8 4 0 0 4 4 4 2 Dopey, N-terminal tRNA_anti-codon PF01336.25 EEA07551.1 - 5.9e-08 32.6 0.6 1.4e-07 31.4 0.6 1.7 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain NAD_kinase PF01513.21 EEA07552.1 - 0.056 12.6 0.0 0.092 11.9 0.0 1.3 1 0 0 1 1 1 0 ATP-NAD kinase TCTP PF00838.17 EEA07552.1 - 0.092 13.1 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 Translationally controlled tumour protein PhoLip_ATPase_C PF16212.5 EEA07554.1 - 1.3e-42 146.3 25.1 1.3e-42 146.3 25.1 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EEA07554.1 - 1.3e-17 63.3 5.2 1.3e-17 63.3 5.2 2.9 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EEA07554.1 - 2.1e-09 38.0 0.7 0.00036 20.9 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA07554.1 - 1e-08 35.1 0.0 4e-07 30.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EEA07554.1 - 7.8e-06 25.5 1.7 7.8e-06 25.5 1.7 3.1 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EEA07554.1 - 0.004 16.9 0.4 0.004 16.9 0.4 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RINGv PF12906.7 EEA07555.1 - 1.1e-11 44.7 6.8 2e-11 43.8 6.8 1.4 1 1 0 1 1 1 1 RING-variant domain Phage_holin_3_6 PF07332.11 EEA07555.1 - 0.29 11.2 3.8 0.4 10.7 3.8 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III AC_N PF16214.5 EEA07555.1 - 0.31 10.1 1.7 0.34 10.0 1.7 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region TssN PF17555.2 EEA07555.1 - 0.35 10.2 10.2 0.46 9.8 10.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF2207 PF09972.9 EEA07555.1 - 1.1 7.9 3.3 1.2 7.8 3.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1700 PF08006.11 EEA07555.1 - 2.3 7.7 8.4 1.5 8.3 7.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1700) PseudoU_synth_2 PF00849.22 EEA07556.1 - 2.9e-24 86.0 0.0 4.6e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EEA07556.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 S4 domain UPF0029 PF01205.19 EEA07557.1 - 4.5e-32 110.5 0.0 6.5e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EEA07557.1 - 0.0068 16.7 0.0 0.018 15.3 0.0 1.7 1 1 0 1 1 1 1 RWD domain Trm112p PF03966.16 EEA07558.1 - 2.2e-11 44.1 0.1 3e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 Trm112p-like protein zf-UDP PF14569.6 EEA07558.1 - 0.014 15.5 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Zinc-binding RING-finger Peptidase_C65 PF10275.9 EEA07561.1 - 2.8e-15 56.4 0.1 3.6e-15 56.1 0.1 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain Peptidase_C65 PF10275.9 EEA07562.1 - 6.7e-31 107.6 0.1 7.3e-31 107.5 0.1 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 EEA07562.1 - 0.0048 17.4 0.0 0.0065 17.0 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease MPS2 PF17060.5 EEA07562.1 - 0.1 11.9 0.1 0.11 11.8 0.1 1.0 1 0 0 1 1 1 0 Monopolar spindle protein 2 Peptidase_M24 PF00557.24 EEA07564.1 - 1.5e-38 132.6 0.0 1.9e-38 132.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 GGACT PF06094.12 EEA07565.1 - 0.041 14.5 0.0 0.071 13.7 0.0 1.4 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 EEA07565.1 - 0.068 13.6 0.1 2.8 8.4 0.0 2.4 2 0 0 2 2 2 0 AIG2-like family DNA_pol_E_B PF04042.16 EEA07566.1 - 6.6e-21 74.6 0.1 1.5e-20 73.5 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B GMC_oxred_N PF00732.19 EEA07567.1 - 2e-16 60.3 0.3 1.2e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EEA07567.1 - 7e-09 36.3 0.0 2e-08 34.8 0.0 1.8 1 1 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EEA07567.1 - 2.7e-05 24.3 0.9 6.6e-05 23.1 0.9 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EEA07567.1 - 0.00012 21.4 0.4 0.00025 20.4 0.4 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EEA07567.1 - 0.00056 19.6 0.4 0.00094 18.9 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EEA07567.1 - 0.002 17.3 0.5 0.0039 16.3 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EEA07567.1 - 0.0027 16.5 0.1 0.0046 15.7 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EEA07567.1 - 0.0048 17.4 1.6 0.059 13.9 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EEA07567.1 - 0.0053 16.4 0.2 0.01 15.5 0.2 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 EEA07567.1 - 0.0072 15.4 0.1 0.01 14.9 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Use1 PF09753.9 EEA07567.1 - 0.012 15.3 9.6 0.026 14.3 9.6 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 Thi4 PF01946.17 EEA07567.1 - 0.038 13.2 0.1 0.11 11.7 0.1 1.8 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 EEA07567.1 - 0.044 13.0 0.1 0.066 12.4 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 EEA07567.1 - 0.14 11.5 0.1 1.5 8.1 0.0 2.4 3 0 0 3 3 3 0 ThiF family GIDA PF01134.22 EEA07567.1 - 5.7 5.9 6.3 0.32 10.0 0.2 2.0 2 1 1 3 3 3 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EEA07567.1 - 6.1 6.0 7.8 0.19 10.9 0.3 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Glutaredoxin PF00462.24 EEA07571.1 - 7.1e-14 51.8 0.5 9.8e-14 51.3 0.5 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 EEA07571.1 - 0.00047 20.1 0.6 0.00089 19.3 0.6 1.4 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_9 PF14595.6 EEA07571.1 - 0.0087 15.8 0.1 0.011 15.5 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EEA07571.1 - 0.065 13.7 0.4 0.1 13.0 0.4 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain DUF836 PF05768.14 EEA07571.1 - 0.068 13.6 1.1 0.11 12.9 1.2 1.5 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) RRM_DME PF15628.6 EEA07572.1 - 0.042 14.0 0.0 0.36 11.0 0.0 2.7 2 0 0 2 2 2 0 RRM in Demeter Pox_A12 PF04651.13 EEA07575.1 - 1.7 8.7 5.5 9 6.3 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A12 protein GPS PF01825.21 EEA07577.1 - 0.015 15.8 8.5 0.021 15.3 1.9 2.9 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif FAM60A PF15396.6 EEA07579.1 - 0.13 12.3 4.5 0.16 12.0 4.5 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 EEA07579.1 - 0.38 9.5 10.0 0.44 9.2 10.0 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EEA07579.1 - 1.8 7.1 16.2 1.7 7.1 16.2 1.0 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EEA07579.1 - 3.2 6.5 13.4 4 6.2 13.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 EEA07579.1 - 4.3 5.5 9.9 4.6 5.4 9.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDK5_activator PF03261.15 EEA07579.1 - 4.8 6.6 10.6 4.9 6.6 10.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein SPX PF03105.19 EEA07579.1 - 6.1 6.7 15.1 6.6 6.5 15.1 1.1 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 EEA07579.1 - 9 4.8 16.3 10 4.7 16.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Coat_X PF07552.11 EEA07583.1 - 0.19 11.6 0.3 0.32 10.8 0.3 1.4 1 0 0 1 1 1 0 Spore Coat Protein X and V domain Nuc_sug_transp PF04142.15 EEA07585.1 - 1e-68 231.9 28.7 6.2e-43 147.1 10.6 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter PUNUT PF16913.5 EEA07585.1 - 9.6e-09 34.9 11.8 2.3e-08 33.7 11.8 1.6 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 EEA07585.1 - 7.7e-07 29.4 34.2 5.4e-06 26.6 11.3 3.3 2 2 0 2 2 2 2 EamA-like transporter family TMEM234 PF10639.9 EEA07585.1 - 0.00011 22.2 8.4 0.03 14.4 0.9 2.7 2 0 0 2 2 2 2 Putative transmembrane family 234 EmrE PF13536.6 EEA07585.1 - 0.0021 17.7 7.2 0.0021 17.7 7.2 2.3 1 1 1 2 2 2 1 Putative multidrug resistance efflux transporter Ost5 PF05251.12 EEA07585.1 - 0.056 13.7 0.3 0.056 13.7 0.3 3.2 3 1 1 4 4 4 0 Oligosaccharyltransferase subunit 5 E1-E2_ATPase PF00122.20 EEA07586.1 - 1.2e-13 50.9 0.0 1.2e-13 50.9 0.0 3.5 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EEA07586.1 - 1.1e-09 38.9 0.0 8.8e-06 26.1 0.1 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA07586.1 - 0.024 14.7 0.1 0.06 13.4 0.1 1.7 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EEA07586.1 - 0.077 12.7 13.5 0.12 12.1 0.4 4.2 3 2 1 4 4 4 0 haloacid dehalogenase-like hydrolase OHA PF14418.6 EEA07587.1 - 1.1e-27 95.6 0.0 3.6e-27 94.0 0.0 2.0 1 0 0 1 1 1 1 OST-HTH Associated domain OST-HTH PF12872.7 EEA07587.1 - 0.00028 20.6 0.1 0.0013 18.5 0.1 2.2 2 0 0 2 2 2 1 OST-HTH/LOTUS domain Bromodomain PF00439.25 EEA07588.1 - 1.8e-21 76.0 0.3 4.1e-21 74.8 0.1 1.7 2 0 0 2 2 2 1 Bromodomain BET PF17035.5 EEA07588.1 - 0.0013 18.8 0.0 0.0029 17.7 0.0 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation AAA_lid_1 PF17857.1 EEA07588.1 - 0.024 14.8 0.0 0.054 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA+ lid domain TPR_MLP1_2 PF07926.12 EEA07589.1 - 0.00067 19.7 46.1 0.0023 18.0 14.9 4.4 3 2 2 5 5 5 3 TPR/MLP1/MLP2-like protein DUF429 PF04250.13 EEA07589.1 - 0.19 11.5 0.2 0.68 9.7 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF429) FUSC PF04632.12 EEA07589.1 - 0.88 8.0 2.0 1.3 7.5 2.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Golgin_A5 PF09787.9 EEA07589.1 - 1.3 8.4 35.4 0.34 10.3 6.7 3.1 3 0 0 3 3 3 0 Golgin subfamily A member 5 KASH_CCD PF14662.6 EEA07589.1 - 1.5 8.6 44.7 1.1 9.1 13.3 3.5 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH ArAE_2_N PF10337.9 EEA07589.1 - 1.6 7.6 8.5 3.4 6.6 8.5 1.5 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Lipoprotein_20 PF13942.6 EEA07589.1 - 5 7.0 25.9 1.4 8.8 7.0 4.0 4 0 0 4 4 4 0 YfhG lipoprotein Bacillus_HBL PF05791.11 EEA07589.1 - 6.1 6.6 22.4 0.033 14.0 2.0 4.0 3 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) tRNA_U5-meth_tr PF05958.11 EEA07590.1 - 9.8e-10 37.9 0.1 2.2e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EEA07590.1 - 2.9e-09 36.9 0.0 5.3e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA07590.1 - 5.7e-06 26.9 0.0 1.1e-05 26.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EEA07590.1 - 0.00071 19.0 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EEA07590.1 - 0.0035 16.9 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain N6_Mtase PF02384.16 EEA07590.1 - 0.008 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_4 PF02390.17 EEA07590.1 - 0.021 14.3 0.0 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.6 EEA07590.1 - 0.033 14.2 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Polbeta PF18765.1 EEA07592.1 - 0.014 15.5 0.0 0.064 13.3 0.0 2.2 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 EEA07592.1 - 0.033 14.5 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 Nucleotidyltransferase domain Tam41_Mmp37 PF09139.11 EEA07593.1 - 1.5e-29 103.5 0.7 1.2e-22 80.8 0.1 2.2 2 0 0 2 2 2 2 Phosphatidate cytidylyltransferase, mitochondrial SMC_N PF02463.19 EEA07594.1 - 1.6e-60 204.3 0.3 4.3e-60 202.9 0.3 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EEA07594.1 - 4.6e-19 68.8 0.0 1.7e-18 67.0 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EEA07594.1 - 2e-13 50.8 21.8 8.3e-09 35.7 1.2 4.1 2 2 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EEA07594.1 - 4.9e-09 37.0 27.6 4.9e-09 37.0 27.6 7.8 3 2 3 6 6 3 1 AAA domain AAA_29 PF13555.6 EEA07594.1 - 9.7e-08 31.6 0.0 2.2e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 EEA07594.1 - 0.00027 21.1 0.0 0.0013 18.9 0.0 2.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EEA07594.1 - 0.0029 18.1 3.3 0.0029 18.1 3.3 6.4 5 3 0 5 5 4 1 ABC transporter DUF2939 PF11159.8 EEA07594.1 - 0.049 14.0 0.1 8.1 6.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2939) AAA_5 PF07728.14 EEA07594.1 - 0.059 13.4 0.3 2.7 8.0 0.0 3.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA07594.1 - 0.13 12.5 2.2 2.8 8.2 0.0 4.1 4 2 1 5 5 5 0 AAA domain AAA_27 PF13514.6 EEA07594.1 - 0.29 10.7 0.0 0.29 10.7 0.0 3.3 4 1 0 4 4 4 0 AAA domain Peptidase_M16 PF00675.20 EEA07595.1 - 1.6e-07 31.4 0.5 3.9e-07 30.1 0.5 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA07595.1 - 3.4e-06 27.2 0.2 9.6e-05 22.5 0.1 2.5 2 0 0 2 2 2 1 Peptidase M16 inactive domain RE_SacI PF09566.10 EEA07595.1 - 0.011 15.5 0.8 5 6.9 0.0 2.3 2 0 0 2 2 2 0 SacI restriction endonuclease Sec63 PF02889.16 EEA07596.1 - 1.3e-60 204.7 24.9 6.7e-29 100.8 4.0 4.1 4 1 0 4 4 4 3 Sec63 Brl domain DEAD PF00270.29 EEA07596.1 - 9.2e-51 172.1 0.3 4.5e-24 85.2 0.3 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EEA07596.1 - 3.7e-24 85.6 0.1 1e-11 45.2 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA07596.1 - 1.4e-19 70.5 2.9 2.1e-08 34.5 0.0 5.5 4 2 1 5 5 5 2 Helicase conserved C-terminal domain AAA_7 PF12775.7 EEA07596.1 - 0.024 14.2 2.2 5.3 6.5 0.1 2.9 3 0 0 3 3 3 0 P-loop containing dynein motor region T2SSE PF00437.20 EEA07596.1 - 0.027 13.5 0.0 6.1 5.8 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 EEA07596.1 - 0.039 13.4 0.0 6.1 6.2 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein IstB_IS21 PF01695.17 EEA07596.1 - 0.092 12.5 0.0 11 5.7 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein UvrD-helicase PF00580.21 EEA07596.1 - 0.49 9.9 7.1 6.8 6.1 0.1 3.8 4 0 0 4 4 4 0 UvrD/REP helicase N-terminal domain dCMP_cyt_deam_1 PF00383.23 EEA07597.1 - 1.1e-25 89.5 2.1 1.9e-25 88.6 2.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EEA07597.1 - 8.6e-16 57.9 0.2 1.7e-15 57.0 0.2 1.5 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 EEA07597.1 - 0.003 18.1 1.9 0.0054 17.3 0.1 2.2 2 0 0 2 2 2 1 AAA domain GRIP PF01465.20 EEA07597.1 - 0.0042 17.0 1.0 0.01 15.7 1.0 1.7 1 0 0 1 1 1 1 GRIP domain SNAD4 PF18750.1 EEA07597.1 - 0.038 14.1 1.1 0.13 12.4 1.1 2.0 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 AAA_17 PF13207.6 EEA07597.1 - 0.047 14.1 0.0 0.082 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA07597.1 - 0.22 11.7 0.0 0.51 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain APOBEC4_like PF18774.1 EEA07597.1 - 0.97 9.4 8.4 0.14 12.1 2.6 2.5 2 1 1 3 3 3 0 APOBEC4-like -AID/APOBEC-deaminase DFRP_C PF16543.5 EEA07598.1 - 5.3e-16 58.9 5.1 5.3e-16 58.9 5.1 2.9 2 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 THUMP PF02926.17 EEA07599.1 - 2.9e-05 24.2 0.5 0.0085 16.2 0.1 2.6 2 0 0 2 2 2 2 THUMP domain SYF2 PF08231.12 EEA07600.1 - 1.2e-08 35.5 7.0 1.2e-08 35.5 7.0 1.8 1 1 1 2 2 2 1 SYF2 splicing factor Pro_isomerase PF00160.21 EEA07600.1 - 0.0024 18.2 0.2 0.019 15.2 0.2 2.3 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ras_bdg_2 PF14847.6 EEA07600.1 - 0.045 14.1 1.4 0.37 11.2 0.2 2.5 2 0 0 2 2 2 0 Ras-binding domain of Byr2 Spt4 PF06093.13 EEA07601.1 - 3.8e-30 103.8 0.6 5.2e-30 103.4 0.6 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Methyltransf_11 PF08241.12 EEA07602.1 - 2.2e-18 66.7 0.0 2.3e-17 63.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA07602.1 - 4.6e-16 59.4 0.0 9.3e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA07602.1 - 9.7e-15 54.7 0.1 1.3e-12 47.7 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA07602.1 - 6.4e-14 52.1 0.0 1.4e-13 51.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA07602.1 - 2.2e-13 50.7 0.0 4.7e-11 43.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EEA07602.1 - 8.7e-05 22.2 0.0 0.0022 17.6 0.0 2.0 1 1 1 2 2 2 2 Nodulation protein S (NodS) Methyltransf_4 PF02390.17 EEA07602.1 - 0.00016 21.2 0.1 0.00079 18.9 0.1 2.0 2 0 0 2 2 2 1 Putative methyltransferase PrmA PF06325.13 EEA07602.1 - 0.00032 20.2 0.1 0.00052 19.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EEA07602.1 - 0.00037 19.9 0.1 0.44 9.8 0.0 2.4 1 1 1 2 2 2 2 Mycolic acid cyclopropane synthetase MetW PF07021.12 EEA07602.1 - 0.0012 18.5 0.3 1 8.9 0.1 2.3 1 1 0 2 2 2 2 Methionine biosynthesis protein MetW MTS PF05175.14 EEA07602.1 - 0.0032 17.0 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EEA07602.1 - 0.0048 16.9 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EEA07602.1 - 0.068 12.1 0.1 6.9 5.5 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) TPMT PF05724.11 EEA07602.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Ank_2 PF12796.7 EEA07603.1 - 2.1e-13 50.7 0.1 1.1e-07 32.3 0.0 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA07603.1 - 8e-09 35.9 0.5 0.0016 19.0 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA07603.1 - 9.6e-08 31.7 1.0 0.0011 19.3 0.0 4.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EEA07603.1 - 1.2e-07 31.9 0.5 2.4e-06 27.7 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EEA07603.1 - 4.9e-05 23.5 0.5 0.002 18.4 0.1 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) PH PF00169.29 EEA07603.1 - 0.00049 20.6 0.0 0.0018 18.7 0.0 2.1 1 0 0 1 1 1 1 PH domain DUF4351 PF14261.6 EEA07605.1 - 0.51 10.4 3.3 5.3 7.2 0.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4351) PMC2NT PF08066.12 EEA07605.1 - 3.8 8.3 7.9 2.8 8.7 0.6 2.4 1 1 0 2 2 2 0 PMC2NT (NUC016) domain Ribosomal_S28e PF01200.18 EEA07606.1 - 7.8e-31 105.9 0.9 9.3e-31 105.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e DUF3450 PF11932.8 EEA07607.1 - 0.039 13.3 28.7 0.099 11.9 1.1 4.4 3 1 2 5 5 5 0 Protein of unknown function (DUF3450) MbeD_MobD PF04899.12 EEA07607.1 - 5.2 7.3 7.2 7.5 6.7 0.2 4.0 3 1 0 3 3 3 0 MbeD/MobD like BTV_NS2 PF04514.12 EEA07608.1 - 2 7.2 7.3 3.2 6.5 7.3 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF842 PF05811.13 EEA07609.1 - 3.2e-14 52.8 13.0 5.4e-14 52.0 13.0 1.5 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) DUF5082 PF16888.5 EEA07609.1 - 0.034 14.4 2.8 0.38 11.0 1.7 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) Filament PF00038.21 EEA07609.1 - 0.035 13.7 0.2 0.048 13.2 0.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein AATF-Che1 PF13339.6 EEA07609.1 - 0.12 13.1 0.6 0.29 11.8 0.2 1.8 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor ACCA PF03255.14 EEA07609.1 - 0.15 11.9 0.1 0.31 10.9 0.1 1.5 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Exo5 PF09810.9 EEA07610.1 - 1.1e-62 212.7 14.1 4.1e-62 210.8 14.1 1.9 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EEA07610.1 - 0.072 13.0 2.5 1.8 8.4 0.0 3.2 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily SCRG1 PF15224.6 EEA07610.1 - 0.28 11.3 3.1 0.32 11.1 0.2 2.6 2 0 0 2 2 2 0 Scrapie-responsive protein 1 ATP-synt_C PF00137.21 EEA07612.1 - 2.1e-31 108.1 39.8 2.9e-19 69.2 16.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Nop10p PF04135.12 EEA07613.1 - 6.4e-22 77.4 0.2 7.4e-22 77.1 0.2 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family ATP-synt_C PF00137.21 EEA07614.1 - 8.3e-30 102.9 37.5 1.4e-17 63.7 18.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C zf-C2H2_jaz PF12171.8 EEA07615.1 - 1e-09 38.4 4.5 1.8e-09 37.7 4.5 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EEA07615.1 - 0.0034 17.7 0.0 0.0034 17.7 0.0 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 EEA07615.1 - 0.014 15.2 1.2 0.024 14.4 1.2 1.3 1 0 0 1 1 1 0 U1 zinc finger Pneumo_M2 PF07380.11 EEA07615.1 - 0.088 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Pneumovirus M2 protein zf_C2H2_ZHX PF18387.1 EEA07615.1 - 0.12 12.0 0.1 0.12 12.0 0.1 1.8 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain WD40 PF00400.32 EEA07617.1 - 0.036 14.9 0.2 3.7 8.6 0.1 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat Sec66 PF09802.9 EEA07618.1 - 0.00061 19.4 5.4 0.001 18.7 5.4 1.4 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 CorA PF01544.18 EEA07618.1 - 0.055 12.8 0.0 0.055 12.8 0.0 2.3 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein Dynamin_M PF01031.20 EEA07619.1 - 2.3e-77 260.0 1.2 8.8e-77 258.1 0.0 2.4 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EEA07619.1 - 2.4e-49 167.6 0.3 6.4e-49 166.2 0.0 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 EEA07619.1 - 9.6e-25 86.6 0.6 9.6e-25 86.6 0.6 3.1 4 0 0 4 4 4 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EEA07619.1 - 0.00056 20.0 0.0 0.0017 18.4 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Imm43 PF15570.6 EEA07619.1 - 0.004 17.2 0.9 0.004 17.2 0.9 1.8 2 0 0 2 2 2 1 Immunity protein 43 YcbB PF08664.10 EEA07619.1 - 0.078 13.0 0.0 0.28 11.2 0.0 2.0 1 0 0 1 1 1 0 YcbB domain Phage_sheath_1 PF04984.14 EEA07619.1 - 0.11 12.3 1.1 0.89 9.4 0.1 2.5 3 0 0 3 3 3 0 Phage tail sheath protein subtilisin-like domain tRNA_lig_kinase PF08303.11 EEA07619.1 - 0.14 12.3 2.0 0.51 10.4 1.9 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain CDC50 PF03381.15 EEA07620.1 - 1.3e-69 234.8 0.0 2.2e-69 234.1 0.0 1.3 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF4282 PF14110.6 EEA07620.1 - 0.16 12.7 4.0 4.4 8.1 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Leu_zip PF15294.6 EEA07621.1 - 0.0062 16.1 6.4 0.012 15.1 6.4 1.6 1 0 0 1 1 1 1 Leucine zipper Glyco_hydro_65m PF03632.15 EEA07621.1 - 0.017 14.0 0.8 0.028 13.3 0.8 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain YabA PF06156.13 EEA07621.1 - 0.026 15.2 1.3 0.026 15.2 1.3 3.2 2 1 1 3 3 3 0 Initiation control protein YabA DUF724 PF05266.14 EEA07621.1 - 0.095 12.5 2.6 0.22 11.3 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Cnn_1N PF07989.11 EEA07621.1 - 0.26 11.5 4.9 2.4 8.4 4.7 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 HMMR_C PF15908.5 EEA07621.1 - 0.26 11.5 4.2 0.87 9.8 4.2 1.8 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal YlqD PF11068.8 EEA07621.1 - 0.43 11.0 3.4 0.28 11.6 0.8 2.1 2 0 0 2 2 2 0 YlqD protein Talin_middle PF09141.10 EEA07622.1 - 0.11 12.5 1.5 0.14 12.2 1.5 1.3 1 1 0 1 1 1 0 Talin, middle domain CBF PF03914.17 EEA07623.1 - 2e-34 119.1 3.8 1.6e-33 116.1 0.6 3.0 3 0 0 3 3 3 1 CBF/Mak21 family HEAT_UF PF18817.1 EEA07623.1 - 0.02 15.2 0.3 0.07 13.4 0.3 2.0 1 0 0 1 1 1 0 Repeat of uncharacterized protein PH0542 Annexin_like PF18411.1 EEA07623.1 - 0.24 11.7 2.9 3.7 7.9 0.1 3.8 4 0 0 4 4 4 0 Annexin-like domain MRAP PF15183.6 EEA07624.1 - 0.25 11.3 1.9 0.65 10.0 0.2 2.4 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family RRM_1 PF00076.22 EEA07625.1 - 1.1e-08 34.7 0.1 2.5e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Synapsin PF02078.16 EEA07625.1 - 0.04 14.2 0.2 0.67 10.3 0.1 2.7 2 0 0 2 2 2 0 Synapsin, N-terminal domain ELM2 PF01448.24 EEA07626.1 - 2.1e-06 28.4 0.2 4.6e-06 27.3 0.1 1.8 2 0 0 2 2 2 1 ELM2 domain Patatin PF01734.22 EEA07627.1 - 1e-18 68.3 0.6 7.9e-17 62.1 0.6 2.7 2 1 0 2 2 2 1 Patatin-like phospholipase PheRS_DBD3 PF18553.1 EEA07627.1 - 0.06 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 PheRS DNA binding domain 3 DUF4646 PF15496.6 EEA07627.1 - 0.14 12.8 0.0 0.27 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4646) EF-hand_1 PF00036.32 EEA07628.1 - 5.2e-19 66.3 3.9 8e-06 25.0 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EEA07628.1 - 2e-18 64.7 6.4 7.8e-07 28.5 0.2 3.9 4 1 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EEA07628.1 - 3.4e-16 59.4 5.6 2.8e-10 40.5 1.6 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EEA07628.1 - 1.3e-13 49.7 2.8 9.5e-05 21.7 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EEA07628.1 - 7.9e-13 48.0 2.9 1.2e-05 25.1 0.2 3.8 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 EEA07628.1 - 8.6e-07 29.2 0.5 0.14 12.5 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 EEA07628.1 - 7.9e-05 22.6 1.3 0.087 12.8 0.6 2.7 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EEA07628.1 - 0.007 16.3 2.2 1.1 9.2 0.0 3.0 1 1 1 2 2 2 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 EEA07628.1 - 0.039 14.3 0.7 4.5 7.6 0.0 3.0 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Toprim_2 PF13155.6 EEA07628.1 - 0.061 13.8 0.1 7.2 7.1 0.0 2.8 2 1 1 3 3 3 0 Toprim-like GatB_Yqey PF02637.18 EEA07628.1 - 0.12 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 GatB domain WD40 PF00400.32 EEA07629.1 - 4.6e-14 52.6 24.6 0.004 18.0 0.1 6.7 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07629.1 - 5.2e-07 29.9 1.6 0.41 11.0 0.1 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EEA07629.1 - 0.19 11.8 0.1 18 5.4 0.0 3.0 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region HA2 PF04408.23 EEA07630.1 - 3.7e-26 91.5 0.1 1.1e-25 90.0 0.0 1.8 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA07630.1 - 1.2e-19 70.5 0.0 3.5e-19 69.0 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA07630.1 - 7.5e-11 42.4 0.0 2.6e-10 40.6 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA07630.1 - 3.1e-08 33.6 0.1 6.4e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA07630.1 - 1.2e-06 28.9 1.3 3.1e-06 27.5 0.1 2.3 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EEA07630.1 - 0.00017 22.0 0.0 0.00033 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EEA07630.1 - 0.00086 19.3 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 EEA07630.1 - 0.0032 17.2 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EEA07630.1 - 0.0085 15.7 0.0 0.017 14.7 0.0 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_23 PF13476.6 EEA07630.1 - 0.0088 16.6 0.0 0.0088 16.6 0.0 2.6 2 1 1 3 3 2 1 AAA domain ResIII PF04851.15 EEA07630.1 - 0.0093 16.0 0.0 3.9 7.5 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EEA07630.1 - 0.011 15.3 0.2 0.081 12.4 0.0 2.3 3 0 0 3 3 3 0 PhoH-like protein AAA_7 PF12775.7 EEA07630.1 - 0.016 14.7 0.5 0.058 12.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 EEA07630.1 - 0.037 14.5 0.1 0.47 11.0 0.1 2.4 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 EEA07630.1 - 0.043 13.2 0.0 0.086 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiC Zot PF05707.12 EEA07630.1 - 0.045 13.4 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) TsaE PF02367.17 EEA07630.1 - 0.047 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EEA07630.1 - 0.12 12.1 0.0 4.7 6.9 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA PF00004.29 EEA07630.1 - 0.14 12.6 0.2 0.64 10.4 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EEA07630.1 - 0.17 10.9 0.0 0.43 9.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 EEA07630.1 - 0.21 11.6 3.0 0.82 9.7 0.2 3.0 2 1 0 2 2 2 0 AAA domain Glyco_tran_28_C PF04101.16 EEA07632.1 - 9.8e-21 74.4 0.0 1.2e-20 74.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain WD40 PF00400.32 EEA07633.1 - 3.8e-10 40.2 8.1 0.34 11.9 0.2 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07633.1 - 4.4e-09 36.5 0.0 0.069 13.5 0.0 4.9 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 EEA07633.1 - 0.05 12.9 0.1 0.8 8.9 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TIMELESS_C PF05029.13 EEA07634.1 - 4.4e-09 36.1 1.3 1.7e-06 27.5 0.1 2.9 4 0 0 4 4 4 2 Timeless protein C terminal region PCI PF01399.27 EEA07635.1 - 5e-18 65.6 0.8 6.4e-17 62.0 0.0 3.0 2 1 1 3 3 3 1 PCI domain Rpn3_C PF08375.11 EEA07635.1 - 9.6e-10 38.7 0.0 2.1e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal TPR_2 PF07719.17 EEA07635.1 - 0.091 12.9 0.8 0.44 10.8 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_S14 PF00253.21 EEA07636.1 - 1.1e-13 50.7 3.8 1.3e-13 50.5 3.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF1289 PF06945.13 EEA07636.1 - 0.11 12.3 6.9 0.56 10.0 6.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1289) Clat_adaptor_s PF01217.20 EEA07637.1 - 2.6e-51 173.3 4.2 3e-51 173.1 4.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Filamin PF00630.19 EEA07638.1 - 3e-23 82.6 0.0 8.2e-18 65.1 0.0 3.3 3 0 0 3 3 3 2 Filamin/ABP280 repeat Complex1_LYR_2 PF13233.6 EEA07638.1 - 0.34 11.7 0.0 0.34 11.7 0.0 3.4 3 0 0 3 3 3 0 Complex1_LYR-like MPLKIP PF15502.6 EEA07639.1 - 0.15 12.3 2.9 0.39 11.0 0.2 3.0 2 0 0 2 2 2 0 M-phase-specific PLK1-interacting protein tRNA-synt_His PF13393.6 EEA07640.1 - 4e-42 144.6 0.0 5.8e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EEA07640.1 - 4.9e-14 52.2 0.0 2.3e-13 50.1 0.0 2.2 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EEA07640.1 - 9.5e-06 24.9 0.0 0.00015 21.0 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EEA07640.1 - 5.4e-05 23.2 0.1 0.0002 21.4 0.1 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 EEA07640.1 - 0.0021 17.6 0.2 0.0039 16.8 0.2 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs NSP16 PF06460.12 EEA07640.1 - 0.0072 15.5 0.0 0.019 14.1 0.0 1.6 1 0 0 1 1 1 1 Coronavirus NSP16 tRNA-synt_2d PF01409.20 EEA07640.1 - 0.037 13.5 0.0 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) cNMP_binding PF00027.29 EEA07641.1 - 4.1e-34 116.5 0.0 1.2e-07 31.7 0.0 4.4 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain MerR-DNA-bind PF09278.11 EEA07641.1 - 0.014 15.9 0.1 4.1 8.0 0.0 3.0 3 0 0 3 3 3 0 MerR, DNA binding Mst1_SARAH PF11629.8 EEA07641.1 - 1.1 9.4 4.4 5.7 7.1 0.2 3.2 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 TSC22 PF01166.18 EEA07642.1 - 0.046 14.0 5.2 0.93 9.8 0.0 4.0 3 1 0 3 3 3 0 TSC-22/dip/bun family IL4Ra_N PF09238.10 EEA07642.1 - 0.1 13.0 0.7 0.49 10.8 0.4 2.2 2 0 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal Cnn_1N PF07989.11 EEA07642.1 - 0.12 12.6 11.3 1.4 9.1 2.8 4.6 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 RL10P_insert PF17777.1 EEA07642.1 - 0.14 12.2 0.0 0.41 10.7 0.0 1.8 1 0 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P HALZ PF02183.18 EEA07642.1 - 0.3 11.3 8.7 6.1 7.2 0.1 4.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper JIP_LZII PF16471.5 EEA07642.1 - 0.32 11.2 9.8 1.5 9.1 0.1 4.5 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II GIT_CC PF16559.5 EEA07642.1 - 1 9.3 4.8 3.1 7.7 0.1 3.8 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Lzipper-MIP1 PF14389.6 EEA07642.1 - 3.3 8.1 7.0 47 4.4 0.0 3.8 4 0 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 NAP PF00956.18 EEA07643.1 - 2.1e-14 53.3 8.6 2e-13 50.2 8.3 2.0 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Mst1_SARAH PF11629.8 EEA07643.1 - 0.063 13.4 1.9 0.063 13.4 1.9 2.0 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 ANAPC4_WD40 PF12894.7 EEA07644.1 - 4.2e-11 43.0 0.0 0.00011 22.4 0.0 4.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA07644.1 - 1.3e-09 38.5 5.5 1.3 10.0 0.0 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat Frtz PF11768.8 EEA07644.1 - 0.00053 18.4 0.0 0.0018 16.7 0.0 1.8 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 EEA07644.1 - 0.026 14.4 0.0 1 9.2 0.0 2.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EEA07644.1 - 0.027 13.8 0.3 15 4.8 0.0 3.0 2 1 1 3 3 3 0 WD40-like domain PD40 PF07676.12 EEA07644.1 - 0.06 13.3 0.5 64 3.7 0.0 4.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DNA_ligase_A_M PF01068.21 EEA07644.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 ATP dependent DNA ligase domain MutS_V PF00488.21 EEA07645.1 - 4e-73 245.5 0.3 1e-72 244.2 0.3 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EEA07645.1 - 4.1e-26 92.4 1.5 4.1e-26 92.4 1.5 3.2 3 1 0 3 3 3 1 MutS domain III MutS_II PF05188.17 EEA07645.1 - 0.0013 19.1 2.9 0.0021 18.3 0.1 2.9 4 0 0 4 4 4 1 MutS domain II PH_TFIIH PF08567.11 EEA07645.1 - 0.01 16.1 0.2 0.62 10.4 0.1 2.5 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain DUF2884 PF11101.8 EEA07645.1 - 0.018 14.5 0.3 0.068 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) DUF2718 PF10918.8 EEA07645.1 - 0.036 14.6 0.1 0.13 12.8 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2718) AAA_29 PF13555.6 EEA07645.1 - 0.059 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EEA07645.1 - 0.11 12.1 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EEA07645.1 - 0.29 11.6 0.0 0.29 11.6 0.0 4.0 3 1 1 4 4 3 0 AAA domain MutS_IV PF05190.18 EEA07645.1 - 0.95 9.9 6.7 0.97 9.8 4.3 2.4 2 1 0 2 2 1 0 MutS family domain IV LMP PF04778.12 EEA07645.1 - 2.3 8.1 8.2 0.18 11.7 1.5 2.5 2 1 1 3 3 3 0 LMP repeated region NTP_transferase PF00483.23 EEA07646.1 - 2.1e-17 63.6 0.0 6.2e-17 62.0 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EEA07646.1 - 1.4e-09 38.5 0.0 2.1e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 EEA07646.1 - 1.2e-08 34.4 13.5 0.0036 17.0 0.3 3.7 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EEA07646.1 - 6.7e-08 31.9 1.1 1.1e-07 31.1 1.1 1.3 1 0 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 EEA07646.1 - 0.0012 17.1 5.5 0.002 16.4 5.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 EEA07646.1 - 0.39 10.5 17.5 1.4 8.8 0.5 4.3 1 1 3 4 4 4 0 Hexapeptide repeat of succinyl-transferase Dynamin_N PF00350.23 EEA07647.1 - 5.7e-09 36.3 1.5 7.4e-06 26.1 0.0 2.8 3 0 0 3 3 3 2 Dynamin family MMR_HSR1 PF01926.23 EEA07647.1 - 6.5e-09 35.9 0.0 1.8e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA07647.1 - 1.1e-05 25.1 0.0 4.3e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA07647.1 - 0.00014 21.8 2.6 0.036 14.0 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase SRPRB PF09439.10 EEA07647.1 - 0.0092 15.4 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit cobW PF02492.19 EEA07647.1 - 0.012 15.3 0.3 1.2 8.7 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 EEA07647.1 - 0.016 14.5 1.0 0.046 13.0 0.0 2.2 3 0 0 3 3 3 0 Septin AAA_16 PF13191.6 EEA07647.1 - 0.028 14.8 0.0 0.2 12.0 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 EEA07647.1 - 0.04 13.0 0.1 0.088 11.8 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein FeoB_N PF02421.18 EEA07647.1 - 0.043 13.4 1.4 1.6 8.2 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC_tran PF00005.27 EEA07647.1 - 0.045 14.3 0.0 0.16 12.5 0.0 1.9 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 EEA07647.1 - 0.096 12.6 1.1 9.4 6.1 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 EEA07647.1 - 0.11 12.7 0.1 0.37 11.0 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EEA07647.1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain OppC_N PF12911.7 EEA07648.1 - 1.2 9.1 5.7 9.2 6.3 2.6 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MFS_1 PF07690.16 EEA07649.1 - 3.5e-43 147.9 21.5 1.1e-41 143.0 21.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Tmemb_18A PF09771.9 EEA07649.1 - 0.66 10.4 5.1 0.78 10.2 0.0 3.0 3 0 0 3 3 3 0 Transmembrane protein 188 DEAD PF00270.29 EEA07650.1 - 1.6e-35 122.4 0.2 2.8e-35 121.7 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA07650.1 - 1e-27 96.6 1.5 5.9e-27 94.2 0.2 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA07650.1 - 3.3e-05 24.0 0.0 6.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EEA07650.1 - 0.022 14.1 0.1 0.04 13.2 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ChaC PF04752.12 EEA07650.1 - 0.096 12.7 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 ChaC-like protein Aa_trans PF01490.18 EEA07651.1 - 9.3e-16 57.5 37.6 5.9e-12 45.0 22.1 2.7 2 1 1 3 3 3 3 Transmembrane amino acid transporter protein YokU PF14122.6 EEA07651.1 - 0.066 13.2 0.1 0.18 11.8 0.1 1.8 1 0 0 1 1 1 0 YokU-like protein, putative antitoxin Patatin PF01734.22 EEA07652.1 - 1e-09 38.9 0.0 2e-08 34.7 0.0 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase Patatin PF01734.22 EEA07653.1 - 4.7e-23 82.4 0.0 8.6e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3888 PF13027.6 EEA07655.1 - 0.26 11.7 3.3 1.9 9.0 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3888) UQ_con PF00179.26 EEA07656.1 - 1.3e-14 54.0 0.0 2.8e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Baculo_11_kDa PF06143.11 EEA07656.1 - 1.6 8.3 4.7 3.3 7.3 4.7 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family DNA_gyraseB PF00204.25 EEA07657.1 - 0.022 14.2 1.0 0.036 13.5 1.0 1.3 1 0 0 1 1 1 0 DNA gyrase B DUF3685 PF12452.8 EEA07657.1 - 8.3 6.1 10.9 0.57 9.9 3.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3685) DUF4448 PF14610.6 EEA07658.1 - 0.18 11.6 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Dcc1 PF09724.9 EEA07659.1 - 9.1e-30 104.1 1.0 1.8e-28 99.8 1.0 2.5 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Beta_elim_lyase PF01212.21 EEA07659.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase AATF-Che1 PF13339.6 EEA07660.1 - 1e-18 68.4 2.3 2.6e-18 67.0 0.1 2.5 3 0 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 EEA07660.1 - 2.3e-17 63.3 0.0 6.7e-17 61.8 0.0 1.9 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal CRAL_TRIO PF00650.20 EEA07661.1 - 2.9e-32 111.6 0.3 4.2e-32 111.1 0.3 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EEA07661.1 - 5.8e-05 23.3 0.1 0.00011 22.3 0.1 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain IQ PF00612.27 EEA07661.1 - 0.0018 17.9 0.1 0.0048 16.6 0.1 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF3361 PF11841.8 EEA07662.1 - 0.0041 17.1 0.2 0.0069 16.3 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3361) DnaJ_C PF01556.18 EEA07663.1 - 6.3e-39 133.4 1.0 9.6e-39 132.8 1.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EEA07663.1 - 7.3e-24 83.7 1.6 1.5e-23 82.6 1.6 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EEA07663.1 - 3.1e-15 56.3 16.0 5.8e-15 55.4 16.0 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EEA07663.1 - 0.0034 17.3 10.4 0.0076 16.2 3.0 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5625 PF18539.1 EEA07664.1 - 0.076 13.3 2.1 1.2 9.4 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5625) REV PF00424.18 EEA07665.1 - 0.012 15.6 0.2 0.012 15.6 0.2 3.6 2 1 1 4 4 4 0 REV protein (anti-repression trans-activator protein) zf-C2H2_3rep PF18868.1 EEA07665.1 - 0.44 11.2 3.2 4.1 8.1 0.1 2.3 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats Aa_trans PF01490.18 EEA07666.1 - 3.4e-57 194.0 42.7 4e-57 193.8 42.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EEA07666.1 - 8e-07 28.4 27.7 8e-07 28.4 27.7 2.1 1 1 1 2 2 2 1 Tryptophan/tyrosine permease family Ntox35 PF15534.6 EEA07667.1 - 0.95 9.9 9.3 0.062 13.7 3.4 2.0 2 0 0 2 2 2 0 Bacterial toxin 35 zf-CCHC_2 PF13696.6 EEA07668.1 - 7.8e-09 35.2 6.3 1.7e-08 34.1 6.3 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-RING_UBOX PF13445.6 EEA07668.1 - 0.00086 19.3 3.8 0.0022 18.0 3.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger DWNN PF08783.11 EEA07668.1 - 0.0021 18.3 0.2 0.0075 16.5 0.0 2.1 2 0 0 2 2 2 1 DWNN domain zf-RING_2 PF13639.6 EEA07668.1 - 0.0083 16.4 9.1 0.0083 16.4 9.1 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA07668.1 - 0.011 15.6 4.6 0.011 15.6 4.6 2.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA07668.1 - 0.015 15.1 8.1 0.015 15.1 8.1 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF2170 PF09938.9 EEA07668.1 - 0.11 12.2 0.1 0.27 10.9 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2170) zf-C3HC4_4 PF15227.6 EEA07668.1 - 0.18 12.0 12.3 0.11 12.7 9.0 2.4 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING zf-CCHC PF00098.23 EEA07668.1 - 0.2 11.8 3.9 0.54 10.4 3.9 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-Nse PF11789.8 EEA07668.1 - 0.21 11.4 2.6 0.51 10.2 2.6 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 EEA07668.1 - 0.36 11.0 5.2 1.1 9.5 5.2 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_5 PF14634.6 EEA07668.1 - 2.7 8.0 15.5 0.57 10.2 9.1 2.6 2 0 0 2 2 2 0 zinc-RING finger domain Nop25 PF09805.9 EEA07670.1 - 0.003 18.0 7.6 0.0033 17.9 7.6 1.1 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) USP7_C2 PF14533.6 EEA07670.1 - 0.0043 16.8 1.4 0.0051 16.5 1.4 1.1 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal FTR_C PF02741.15 EEA07670.1 - 0.0072 16.4 0.2 0.0094 16.0 0.2 1.1 1 0 0 1 1 1 1 FTR, proximal lobe TMPIT PF07851.13 EEA07670.1 - 0.21 10.8 2.1 0.22 10.7 2.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein RFX5_N PF18326.1 EEA07670.1 - 0.24 11.2 2.0 0.55 10.0 2.0 1.5 1 0 0 1 1 1 0 RFX5 N-terminal domain RabGAP-TBC PF00566.18 EEA07670.1 - 0.25 11.0 1.9 0.29 10.7 1.9 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain EMC3_TMCO1 PF01956.16 EEA07670.1 - 4.9 6.9 5.3 6.3 6.5 5.3 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like NEMP PF10225.9 EEA07671.1 - 0.091 12.4 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 NEMP family DIM1 PF02966.16 EEA07672.1 - 1.9e-63 212.1 0.3 2.1e-63 212.0 0.3 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EEA07672.1 - 0.0051 16.8 0.0 0.0071 16.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Carboxyl_trans PF01039.22 EEA07673.1 - 2.5e-139 465.1 0.0 3.4e-139 464.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EEA07673.1 - 1.2e-47 162.1 0.9 2.3e-47 161.3 0.9 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ACC_central PF08326.12 EEA07673.1 - 1.1e-32 113.1 17.4 5.9e-11 41.3 5.6 5.2 5 0 0 5 5 5 5 Acetyl-CoA carboxylase, central region Biotin_carb_N PF00289.22 EEA07673.1 - 4.8e-27 94.7 0.1 1.1e-26 93.5 0.1 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EEA07673.1 - 1.1e-18 67.3 0.0 2.7e-18 66.0 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EEA07673.1 - 4.1e-08 32.9 0.0 1.1e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 EEA07673.1 - 2.1e-06 27.9 0.5 5e-06 26.6 0.5 1.7 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EEA07673.1 - 1.5e-05 24.7 0.1 3.6e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EEA07673.1 - 3.4e-05 23.5 0.1 7.2e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EEA07673.1 - 0.044 13.4 0.4 0.11 12.1 0.4 1.6 1 0 0 1 1 1 0 RimK-like ATP-grasp domain RTC PF01137.21 EEA07675.1 - 1.3e-37 129.2 0.0 1.5e-37 129.0 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EEA07675.1 - 1.2e-17 64.3 0.0 1.9e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DUF974 PF06159.13 EEA07676.1 - 6.7e-17 62.1 0.2 9.7e-17 61.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.7 EEA07676.1 - 0.00025 20.6 0.1 0.024 14.1 0.0 2.3 1 1 1 2 2 2 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.22 EEA07676.1 - 0.0033 17.5 0.0 0.013 15.6 0.0 2.0 1 1 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain Xrn1_D3 PF18194.1 EEA07676.1 - 0.021 14.9 1.2 5.5 7.2 0.1 2.6 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 Herpes_UL7 PF01677.16 EEA07676.1 - 0.052 13.3 0.2 0.2 11.4 0.1 2.0 1 1 1 2 2 2 0 Herpesvirus UL7 like fn3 PF00041.21 EEA07676.1 - 0.097 13.0 0.2 1.4 9.4 0.0 2.7 3 0 0 3 3 3 0 Fibronectin type III domain Patched PF02460.18 EEA07677.1 - 1.8e-23 82.6 39.8 5.6e-14 51.2 17.7 4.0 3 1 1 4 4 4 3 Patched family Sterol-sensing PF12349.8 EEA07677.1 - 8.2e-11 42.0 28.3 9.6e-11 41.7 1.1 3.7 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation LptF_LptG PF03739.14 EEA07677.1 - 0.0004 19.3 0.1 0.0004 19.3 0.1 2.3 2 0 0 2 2 2 1 Lipopolysaccharide export system permease LptF/LptG TrkA_TMD PF18613.1 EEA07677.1 - 0.049 13.1 5.3 0.16 11.4 5.3 1.9 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain UFC1 PF08694.11 EEA07678.1 - 6.4e-77 256.5 0.6 7.4e-77 256.3 0.6 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 EEA07678.1 - 0.00052 19.7 1.0 0.0023 17.6 1.0 2.0 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EEA07678.1 - 0.026 14.2 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EEA07678.1 - 0.18 12.1 1.0 0.6 10.4 1.0 1.7 1 1 1 2 2 2 0 RWD domain Defensin_4 PF07936.12 EEA07678.1 - 2.8 7.9 6.0 0.42 10.5 2.2 1.6 2 0 0 2 2 2 0 Potassium-channel blocking toxin UPF0370 PF13980.6 EEA07679.1 - 3.7 7.6 5.2 2 8.5 0.1 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0370) Syntaxin-6_N PF09177.11 EEA07680.1 - 0.6 10.7 4.5 0.46 11.1 0.4 3.1 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Herpes_BBRF1 PF04793.12 EEA07681.1 - 0.012 14.7 1.1 0.028 13.5 1.1 1.7 1 0 0 1 1 1 0 BRRF1-like protein SlyX PF04102.12 EEA07681.1 - 1 10.0 9.0 0.72 10.5 0.6 3.9 3 1 1 4 4 4 0 SlyX Pro_CA PF00484.19 EEA07681.1 - 6.8 7.0 6.6 29 4.9 0.0 3.0 2 1 2 4 4 4 0 Carbonic anhydrase Defensin_1 PF00323.19 EEA07686.1 - 3 8.5 10.6 0.64 10.6 0.4 3.0 3 0 0 3 3 3 0 Mammalian defensin DUF4768 PF15989.5 EEA07687.1 - 0.063 13.2 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4768) PITH PF06201.13 EEA07688.1 - 2e-28 99.5 0.5 2.4e-28 99.3 0.5 1.0 1 0 0 1 1 1 1 PITH domain TED_complement PF07678.14 EEA07689.1 - 0.016 14.3 0.3 0.13 11.3 0.0 2.4 2 0 0 2 2 2 0 A-macroglobulin TED domain zf-BED PF02892.15 EEA07689.1 - 0.085 12.9 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 BED zinc finger DUF5045 PF16464.5 EEA07690.1 - 0.057 13.7 0.4 0.35 11.2 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5045) Ribosomal_L18_c PF14204.6 EEA07690.1 - 0.11 13.4 7.6 0.79 10.7 3.8 2.6 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region Ribosomal_L34e PF01199.18 EEA07692.1 - 2.4e-39 133.5 5.2 2.4e-39 133.5 5.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L34e zf-CRD PF17979.1 EEA07692.1 - 0.01 16.0 1.0 0.015 15.4 1.0 1.2 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions SelP_N PF04592.14 EEA07692.1 - 0.04 13.3 2.5 0.087 12.2 1.0 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region zf-RING_2 PF13639.6 EEA07693.1 - 1.4e-09 38.1 13.1 2.5e-09 37.3 13.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EEA07693.1 - 4.9e-07 29.9 9.9 1.4e-06 28.5 9.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EEA07693.1 - 2.8e-06 27.0 12.1 6.6e-06 25.8 12.1 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EEA07693.1 - 1.1e-05 25.1 11.7 2.1e-05 24.3 11.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA07693.1 - 3.5e-05 23.6 11.6 6.7e-05 22.7 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA07693.1 - 0.0029 17.5 9.6 0.0052 16.7 9.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA07693.1 - 0.0046 17.0 7.5 0.0046 17.0 7.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EEA07693.1 - 0.0079 16.2 6.2 0.026 14.6 6.2 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EEA07693.1 - 0.011 15.6 9.2 0.017 15.0 9.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA07693.1 - 0.023 14.3 8.7 0.047 13.3 8.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H_2 PF13832.6 EEA07693.1 - 0.088 13.0 3.3 0.16 12.1 3.3 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain C1_2 PF03107.16 EEA07693.1 - 0.17 12.2 5.8 0.4 11.0 5.8 1.6 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 EEA07693.1 - 0.38 10.7 9.7 0.74 9.7 9.7 1.5 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 EEA07693.1 - 0.71 10.0 6.8 1.6 8.9 6.8 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3H2C3 PF17122.5 EEA07693.1 - 1.2 9.2 6.3 2.9 8.0 6.3 1.7 1 0 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 EEA07693.1 - 2.9 7.9 9.4 1.3 9.0 5.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 tRNA-synt_1g PF09334.11 EEA07694.1 - 4.1e-93 312.2 2.0 2.5e-54 184.5 0.1 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EEA07694.1 - 2.3e-35 121.9 4.0 9.2e-20 70.4 0.3 3.9 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EEA07694.1 - 1e-10 41.5 0.3 1.4e-05 24.6 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EEA07694.1 - 6e-05 22.1 0.0 0.1 11.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) Anticodon_1 PF08264.13 EEA07694.1 - 0.0026 17.8 0.1 0.014 15.4 0.0 2.1 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA Dicistro_VP4 PF11492.8 EEA07694.1 - 0.012 15.6 0.1 0.046 13.7 0.1 2.0 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 tRNA-synt_1b PF00579.25 EEA07694.1 - 0.017 14.4 0.0 0.039 13.3 0.0 1.5 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) Coiled-coil_56 PF09813.9 EEA07694.1 - 0.12 12.5 0.1 0.29 11.2 0.1 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 56 Ribosomal_L22 PF00237.19 EEA07695.1 - 7.4e-26 90.4 0.0 9.6e-26 90.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e HEAT PF02985.22 EEA07696.1 - 1.3e-18 65.5 12.6 1e-05 25.4 0.0 10.1 11 0 0 11 11 11 4 HEAT repeat HEAT_EZ PF13513.6 EEA07696.1 - 1.4e-17 63.8 1.6 8.7e-11 42.1 0.0 6.8 8 0 0 8 8 8 1 HEAT-like repeat HEAT_2 PF13646.6 EEA07696.1 - 1.1e-11 44.9 0.0 0.0042 17.5 0.1 5.5 4 3 3 7 7 7 2 HEAT repeats Cnd1 PF12717.7 EEA07696.1 - 1.2e-10 41.7 1.5 0.045 13.8 0.2 4.9 3 2 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EEA07696.1 - 9.4e-08 31.9 2.1 0.012 15.2 0.1 3.3 4 0 0 4 4 4 2 CLASP N terminal Adaptin_N PF01602.20 EEA07696.1 - 1.7e-05 23.6 4.4 0.0012 17.5 0.4 4.3 4 1 0 4 4 4 1 Adaptin N terminal region IBN_N PF03810.19 EEA07696.1 - 0.00052 19.9 0.1 0.02 14.8 0.0 3.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EEA07696.1 - 0.0014 19.2 0.0 4.6 7.9 0.0 4.1 2 2 1 3 3 3 1 Vacuolar 14 Fab1-binding region TAF6_C PF07571.13 EEA07696.1 - 0.0016 18.7 0.2 5.2 7.5 0.0 5.0 2 2 3 5 5 5 1 TAF6 C-terminal HEAT repeat domain DUF3437 PF11919.8 EEA07696.1 - 0.035 14.0 0.1 4.3 7.3 0.0 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF3437) DUF1298 PF06974.13 EEA07697.1 - 2.7e-28 98.8 0.0 4.8e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) MCPsignal PF00015.21 EEA07698.1 - 0.00015 21.7 1.8 0.00053 19.9 0.6 2.1 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Syntaxin-6_N PF09177.11 EEA07698.1 - 0.0022 18.5 3.9 0.53 10.9 0.8 3.0 2 1 1 3 3 3 1 Syntaxin 6, N-terminal SKA1 PF07160.12 EEA07698.1 - 0.0044 16.9 1.8 1.8 8.3 0.1 2.1 2 0 0 2 2 2 2 Spindle and kinetochore-associated protein 1 Rx_N PF18052.1 EEA07698.1 - 0.0044 17.2 0.1 0.0099 16.1 0.1 1.6 2 0 0 2 2 2 1 Rx N-terminal domain SF-assemblin PF06705.11 EEA07698.1 - 0.011 15.2 7.8 0.018 14.4 0.8 2.4 2 1 0 2 2 2 0 SF-assemblin/beta giardin Arc_PepC_II PF06847.11 EEA07698.1 - 0.011 16.2 0.7 0.056 14.0 0.1 2.3 2 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II TMPIT PF07851.13 EEA07698.1 - 0.012 14.9 1.3 0.5 9.5 0.1 2.1 2 0 0 2 2 2 0 TMPIT-like protein DUF3671 PF12420.8 EEA07698.1 - 0.014 15.5 0.3 0.014 15.5 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function Neprosin PF03080.15 EEA07698.1 - 0.014 14.7 0.2 0.024 14.0 0.2 1.3 1 0 0 1 1 1 0 Neprosin FliT PF05400.13 EEA07698.1 - 0.019 15.7 0.1 0.056 14.3 0.0 1.8 2 0 0 2 2 2 0 Flagellar protein FliT DUF1664 PF07889.12 EEA07698.1 - 0.024 14.7 4.7 2.3 8.3 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SNARE PF05739.19 EEA07698.1 - 0.024 14.6 0.2 0.024 14.6 0.2 2.8 3 0 0 3 3 3 0 SNARE domain GCP_N_terminal PF17681.1 EEA07698.1 - 0.034 13.8 0.8 4.3 6.9 0.1 2.2 2 0 0 2 2 2 0 Gamma tubulin complex component N-terminal Syntaxin PF00804.25 EEA07698.1 - 0.056 13.1 1.4 0.4 10.3 0.1 2.5 2 0 0 2 2 2 0 Syntaxin Corona_S2 PF01601.16 EEA07698.1 - 0.069 11.6 1.2 0.12 10.8 1.2 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein ABC_tran_CTD PF16326.5 EEA07698.1 - 0.077 13.3 1.2 0.41 10.9 0.3 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain Fib_alpha PF08702.10 EEA07698.1 - 0.077 13.2 11.8 2.9 8.1 2.1 3.5 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF4745 PF15923.5 EEA07698.1 - 0.086 12.8 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4745) DUF4234 PF14018.6 EEA07698.1 - 0.097 12.8 0.4 0.25 11.5 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) Baculo_PEP_C PF04513.12 EEA07698.1 - 0.14 12.2 6.1 0.98 9.5 0.7 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Focal_AT PF03623.13 EEA07698.1 - 0.2 11.6 2.2 1.6 8.7 0.2 2.4 2 1 1 3 3 3 0 Focal adhesion targeting region IFT57 PF10498.9 EEA07698.1 - 0.22 10.4 5.1 0.36 9.8 0.5 2.4 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 DUF148 PF02520.17 EEA07698.1 - 4.3 7.5 8.2 1.7 8.8 3.2 2.6 2 2 0 2 2 2 0 Domain of unknown function DUF148 Cyclin_N PF00134.23 EEA07699.1 - 0.00011 22.0 3.9 0.00012 21.8 0.2 2.6 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA07699.1 - 0.00024 21.2 0.7 0.00024 21.2 0.7 2.4 3 1 1 4 4 4 1 Cyclin, C-terminal domain DUF4332 PF14229.6 EEA07699.1 - 0.058 13.6 0.0 0.2 11.9 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4332) FGGY_N PF00370.21 EEA07699.1 - 0.059 12.9 0.1 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain PAE PF03283.13 EEA07699.1 - 0.061 12.4 0.2 0.098 11.8 0.2 1.3 1 0 0 1 1 1 0 Pectinacetylesterase Cyclin_N PF00134.23 EEA07700.1 - 0.00083 19.1 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain HA2 PF04408.23 EEA07701.1 - 1.1e-21 77.1 0.1 3.6e-21 75.5 0.0 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA07701.1 - 1.2e-13 51.2 0.0 3.1e-13 49.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA07701.1 - 5.1e-11 42.9 0.0 1.3e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA07701.1 - 1.1e-08 35.0 0.0 2.3e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA07701.1 - 2.1e-06 28.0 0.0 6.4e-06 26.5 0.0 1.7 2 0 0 2 2 1 1 AAA domain DUF2075 PF09848.9 EEA07701.1 - 6e-05 22.5 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EEA07701.1 - 0.00054 20.3 0.1 0.002 18.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EEA07701.1 - 0.00099 18.9 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EEA07701.1 - 0.001 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain T2SSE PF00437.20 EEA07701.1 - 0.0034 16.5 0.0 0.006 15.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 EEA07701.1 - 0.019 14.6 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EEA07701.1 - 0.047 13.7 3.0 0.091 12.8 0.1 2.9 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EEA07701.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 EEA07701.1 - 0.074 12.4 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 EEA07701.1 - 0.13 12.6 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EEA07701.1 - 0.15 12.5 0.0 0.15 12.5 0.0 3.8 3 1 1 4 4 3 0 AAA domain AAA_33 PF13671.6 EEA07701.1 - 0.2 11.8 0.2 0.56 10.4 0.2 1.9 1 1 0 1 1 1 0 AAA domain EF1G PF00647.19 EEA07701.1 - 6.7 6.8 8.5 15 5.6 7.1 2.3 1 1 1 2 2 2 0 Elongation factor 1 gamma, conserved domain Methyltransf_11 PF08241.12 EEA07702.1 - 3.9e-13 49.9 0.0 7.8e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EEA07702.1 - 2.3e-12 47.4 0.1 6.4e-12 46.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA07702.1 - 4.2e-09 36.4 0.1 7.1e-09 35.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA07702.1 - 1.3e-08 34.8 0.0 3.8e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA07702.1 - 1.5e-07 32.1 0.5 3.1e-07 31.1 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.11 EEA07702.1 - 0.0032 17.1 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) PCMT PF01135.19 EEA07702.1 - 0.0045 16.8 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 EEA07702.1 - 0.0058 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW N6_N4_Mtase PF01555.18 EEA07702.1 - 0.013 15.2 1.1 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 DNA methylase Methyltransf_9 PF08003.11 EEA07702.1 - 0.065 12.1 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CRAL_TRIO PF00650.20 EEA07703.1 - 1.7e-20 73.3 0.8 2.9e-20 72.6 0.8 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EEA07703.1 - 0.0021 18.2 0.3 0.0041 17.3 0.3 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CUE PF02845.16 EEA07703.1 - 0.064 13.0 0.0 0.19 11.4 0.0 1.8 1 0 0 1 1 1 0 CUE domain UBA_4 PF14555.6 EEA07703.1 - 0.091 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain Pkinase PF00069.25 EEA07705.1 - 5.7e-10 39.0 1.9 1.5e-09 37.6 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07705.1 - 3.8e-06 26.4 0.0 1.1e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1512 PF07431.12 EEA07705.1 - 0.028 13.4 2.0 0.047 12.7 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) YlqD PF11068.8 EEA07705.1 - 0.029 14.8 5.6 0.093 13.1 5.6 1.8 1 0 0 1 1 1 0 YlqD protein SH3BP5 PF05276.14 EEA07705.1 - 0.075 12.8 1.8 0.38 10.5 0.3 2.4 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) COG5 PF10392.9 EEA07705.1 - 0.093 12.9 3.5 0.25 11.5 0.9 2.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Prefoldin PF02996.17 EEA07705.1 - 0.14 12.1 10.5 0.097 12.6 4.0 2.5 2 0 0 2 2 2 0 Prefoldin subunit Prefoldin_2 PF01920.20 EEA07705.1 - 0.16 11.9 17.3 0.034 14.1 4.7 3.2 3 0 0 3 3 3 0 Prefoldin subunit DUF4140 PF13600.6 EEA07705.1 - 0.18 12.3 4.1 5.9 7.4 0.5 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Occludin_ELL PF07303.13 EEA07705.1 - 1.5 9.6 6.7 1.3 9.8 0.7 3.3 3 0 0 3 3 3 0 Occludin homology domain DUF1664 PF07889.12 EEA07705.1 - 3.5 7.7 5.7 3.2 7.8 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 EEA07705.1 - 4 7.5 8.0 3.5 7.7 2.9 2.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_1 PF00515.28 EEA07707.1 - 3.8e-07 29.7 0.1 0.00033 20.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EEA07707.1 - 0.00024 21.0 0.0 0.037 14.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA07707.1 - 0.0032 17.7 0.4 1.9 9.1 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 EEA07707.1 - 0.014 14.2 0.3 0.02 13.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) WD40 PF00400.32 EEA07708.1 - 5e-27 93.6 14.1 2.5e-07 31.3 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07708.1 - 5.5e-23 81.1 0.1 2.2e-05 24.6 0.0 6.4 3 1 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EEA07708.1 - 0.0033 16.4 3.0 0.63 9.0 0.0 3.6 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PIG-U PF06728.13 EEA07710.1 - 1.9e-75 254.3 47.9 2.3e-75 254.1 47.9 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Prefoldin_2 PF01920.20 EEA07711.1 - 1.6e-14 53.7 7.2 1.8e-14 53.6 7.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit Snapin_Pallidin PF14712.6 EEA07711.1 - 0.019 15.4 4.9 0.044 14.2 0.3 2.1 2 0 0 2 2 2 0 Snapin/Pallidin BLOC1_2 PF10046.9 EEA07711.1 - 0.027 14.8 5.3 0.092 13.1 0.3 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.22 EEA07711.1 - 0.028 14.6 3.9 1.2 9.4 0.3 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 EEA07711.1 - 0.035 14.2 2.1 1.5 8.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SKA2 PF16740.5 EEA07711.1 - 0.038 13.8 1.5 1.8 8.4 0.1 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF2340 PF10209.9 EEA07711.1 - 0.039 14.4 5.3 0.17 12.3 5.3 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) 7TMR-HDED PF07697.11 EEA07711.1 - 0.066 13.3 1.7 0.075 13.1 1.7 1.1 1 0 0 1 1 1 0 7TM-HD extracellular YabA PF06156.13 EEA07711.1 - 0.14 12.8 3.8 2.2 9.0 0.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 EEA07711.1 - 0.32 11.2 5.0 2.5 8.3 5.0 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FliD_N PF02465.18 EEA07711.1 - 6.7 7.5 8.0 21 5.9 3.1 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Pro_isomerase PF00160.21 EEA07712.1 - 8.3e-49 165.9 0.2 6.6e-48 163.0 0.0 2.2 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EEA07712.1 - 1.7e-07 31.8 2.2 0.72 10.8 0.1 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07712.1 - 0.015 15.6 0.0 4 7.8 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TFIIS_C PF01096.18 EEA07713.1 - 2.4e-22 78.5 3.2 2.4e-22 78.5 3.2 2.8 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 EEA07713.1 - 2.3e-06 27.5 6.5 0.0022 18.0 0.6 2.3 2 0 0 2 2 2 2 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 EEA07713.1 - 5.8e-06 26.1 6.5 1.4e-05 24.9 0.3 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit DUF2387 PF09526.10 EEA07713.1 - 1.4e-05 25.1 3.7 0.0047 17.0 0.2 2.2 1 1 1 2 2 2 2 Probable metal-binding protein (DUF2387) TF_Zn_Ribbon PF08271.12 EEA07713.1 - 7.7e-05 22.1 4.2 0.0019 17.6 0.2 2.4 2 0 0 2 2 2 1 TFIIB zinc-binding Baculo_LEF5_C PF11792.8 EEA07713.1 - 0.019 14.7 3.8 0.049 13.3 0.0 2.7 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain Thioredoxin_3 PF13192.6 EEA07713.1 - 0.023 14.7 0.2 0.023 14.7 0.2 2.9 2 1 2 4 4 4 0 Thioredoxin domain PhnA_Zn_Ribbon PF08274.12 EEA07713.1 - 0.052 13.5 5.8 0.26 11.3 0.0 3.1 3 1 0 3 3 3 0 PhnA Zinc-Ribbon Lar_restr_allev PF14354.6 EEA07713.1 - 0.082 13.3 4.2 3.6 8.1 0.8 2.3 2 0 0 2 2 2 0 Restriction alleviation protein Lar Inhibitor_I29 PF08246.12 EEA07713.1 - 0.1 13.1 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) DZR PF12773.7 EEA07713.1 - 0.15 12.1 11.4 1.5 9.0 6.2 3.0 1 1 1 2 2 2 0 Double zinc ribbon zf-ACC PF17848.1 EEA07713.1 - 0.76 9.9 9.5 13 6.0 0.9 3.5 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain A2L_zn_ribbon PF08792.10 EEA07713.1 - 0.97 9.2 12.2 1.3 8.8 0.0 3.7 3 1 0 3 3 3 0 A2L zinc ribbon domain zf-RING_7 PF02591.15 EEA07713.1 - 1.3 9.3 8.5 6.2 7.1 0.1 3.3 4 0 0 4 4 4 0 C4-type zinc ribbon domain zinc_ribbon_2 PF13240.6 EEA07713.1 - 1.3 8.8 0.1 1.3 8.8 0.1 3.9 4 0 0 4 4 4 0 zinc-ribbon domain Nudix_N_2 PF14803.6 EEA07713.1 - 2.7 8.0 14.3 0.25 11.3 2.7 3.2 3 1 0 3 3 3 0 Nudix N-terminal Zn_Tnp_IS1 PF03811.13 EEA07713.1 - 3.1 7.6 7.2 1.7 8.4 0.2 2.8 3 0 0 3 3 3 0 InsA N-terminal domain zf-Dof PF02701.15 EEA07713.1 - 4.4 7.5 10.2 0.15 12.2 1.8 2.4 3 0 0 3 3 3 0 Dof domain, zinc finger zf-B_box PF00643.24 EEA07713.1 - 4.9 7.4 10.6 7.4 6.8 1.6 3.1 3 0 0 3 3 3 0 B-box zinc finger zinc_ribbon_10 PF10058.9 EEA07713.1 - 7.2 6.4 13.1 2.3 8.0 2.1 3.4 2 2 1 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zinc_ribbon_13 PF09855.9 EEA07713.1 - 9.1 6.5 9.3 8.6 6.6 0.0 3.3 4 0 0 4 4 3 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) RPAP2_Rtr1 PF04181.13 EEA07714.1 - 1.3e-12 47.9 0.2 5.2e-12 45.9 0.2 2.1 1 0 0 1 1 1 1 Rtr1/RPAP2 family Ldh_1_N PF00056.23 EEA07716.1 - 4.5e-34 117.5 0.5 7.1e-34 116.9 0.5 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA07716.1 - 3.3e-23 82.5 0.0 5.1e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 EEA07716.1 - 0.019 14.6 0.0 0.045 13.3 0.0 1.6 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase 3HCDH_N PF02737.18 EEA07716.1 - 0.024 14.5 0.5 0.046 13.6 0.5 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lambda_CIII PF02061.16 EEA07716.1 - 0.044 13.8 0.2 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 Lambda Phage CIII K_oxygenase PF13434.6 EEA07716.1 - 0.094 11.8 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Ldh_1_N PF00056.23 EEA07717.1 - 1.7e-43 148.1 0.1 1e-42 145.6 0.1 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EEA07717.1 - 1.6e-25 90.0 0.0 4e-25 88.7 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UDPG_MGDP_dh_N PF03721.14 EEA07717.1 - 0.00038 20.1 1.2 0.0027 17.3 1.2 2.2 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_hydro_4 PF02056.16 EEA07717.1 - 0.0053 16.3 2.1 0.027 14.0 0.2 2.6 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase Shikimate_DH PF01488.20 EEA07717.1 - 0.013 15.6 0.1 0.12 12.4 0.1 2.4 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EEA07717.1 - 0.35 11.5 2.9 2.2 8.9 2.9 2.5 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EEA07717.1 - 0.45 10.1 2.1 1.5 8.5 2.1 2.0 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA E1-E2_ATPase PF00122.20 EEA07718.1 - 1e-28 100.1 1.5 6.9e-21 74.6 0.0 3.5 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 EEA07718.1 - 1.3e-13 51.7 0.5 1.3e-07 32.1 0.1 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EEA07718.1 - 7e-06 26.0 0.0 2e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EEA07719.1 - 1.7e-16 60.3 0.1 1.7e-16 60.3 0.1 2.0 1 1 0 2 2 2 1 E1-E2 ATPase CTP_transf_1 PF01148.20 EEA07720.1 - 1.3e-69 234.9 19.8 1.7e-69 234.5 19.8 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family RIO1 PF01163.22 EEA07721.1 - 7.6e-45 152.8 0.0 7.6e-45 152.8 0.0 2.0 2 1 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 EEA07721.1 - 1.4e-31 108.5 0.2 3.7e-31 107.2 0.2 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EEA07721.1 - 4.2e-07 30.1 0.7 0.025 14.5 0.9 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EEA07721.1 - 0.00024 20.5 0.1 0.0022 17.4 0.1 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EEA07721.1 - 0.01 15.2 0.1 0.021 14.2 0.1 1.4 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 EEA07722.1 - 9.6e-64 215.3 0.0 1.2e-63 215.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07722.1 - 1.2e-30 106.7 0.0 1.6e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA07722.1 - 0.00066 18.7 0.0 0.00089 18.3 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EEA07722.1 - 0.0035 16.7 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EEA07722.1 - 0.0042 16.5 0.0 0.006 15.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA07722.1 - 0.023 13.5 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SNF2_N PF00176.23 EEA07723.1 - 2.2e-44 151.6 0.2 2e-39 135.3 0.0 2.8 3 0 0 3 3 3 2 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 EEA07723.1 - 3e-07 30.2 6.8 3e-07 30.2 6.8 4.1 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 EEA07723.1 - 5.9e-06 26.6 1.9 1.5e-05 25.3 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 EEA07723.1 - 3.7e-05 24.0 8.4 3.7e-05 24.0 8.4 4.4 3 1 0 3 3 3 1 Ring finger domain zf-RING_4 PF14570.6 EEA07723.1 - 5.5e-05 22.9 6.8 5.5e-05 22.9 6.8 3.6 3 1 0 3 3 2 1 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 EEA07723.1 - 0.0001 22.1 10.5 0.0001 22.1 10.5 4.6 4 2 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA07723.1 - 0.0035 17.2 8.5 0.0035 17.2 8.5 5.0 4 2 1 5 5 4 1 Prokaryotic RING finger family 4 zf-UDP PF14569.6 EEA07723.1 - 0.0044 17.1 2.8 0.0044 17.1 2.8 2.4 2 0 0 2 2 2 1 Zinc-binding RING-finger zf-RING_UBOX PF13445.6 EEA07723.1 - 0.0072 16.3 7.8 0.0072 16.3 7.8 2.6 2 0 0 2 2 2 1 RING-type zinc-finger Rad50_zn_hook PF04423.14 EEA07723.1 - 0.028 14.3 0.3 3 7.8 0.0 3.4 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF4771 PF15995.5 EEA07723.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4771) TPR_2 PF07719.17 EEA07723.1 - 0.12 12.5 0.6 13 6.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Rtf2 PF04641.12 EEA07723.1 - 0.25 10.7 6.4 0.54 9.6 5.2 2.2 1 1 0 1 1 1 0 Rtf2 RING-finger Chordopox_A13L PF05961.11 EEA07724.1 - 0.067 13.4 4.4 1.3 9.3 0.2 2.9 2 0 0 2 2 2 0 Chordopoxvirus A13L protein OHA PF14418.6 EEA07725.1 - 7.9e-28 96.1 1.0 4.3e-27 93.7 0.1 2.9 3 0 0 3 3 3 1 OST-HTH Associated domain OST-HTH PF12872.7 EEA07725.1 - 0.00078 19.2 0.1 0.074 12.9 0.0 2.4 2 0 0 2 2 2 2 OST-HTH/LOTUS domain DUF2677 PF10838.8 EEA07725.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2677) AAA_18 PF13238.6 EEA07727.1 - 4.4e-07 30.5 1.1 1.8e-06 28.5 1.1 2.3 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EEA07727.1 - 9.8e-07 28.2 0.0 8.1e-05 22.0 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EEA07727.1 - 5.9e-06 26.5 0.2 1.3e-05 25.4 0.2 1.5 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EEA07727.1 - 2.4e-05 24.1 0.4 0.025 14.2 0.1 2.4 2 0 0 2 2 2 2 Thymidylate kinase APS_kinase PF01583.20 EEA07727.1 - 0.00063 19.7 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase Cytidylate_kin PF02224.18 EEA07727.1 - 0.002 17.9 0.1 0.0033 17.2 0.1 1.4 1 0 0 1 1 1 1 Cytidylate kinase T2SSE PF00437.20 EEA07727.1 - 0.0039 16.3 0.9 0.032 13.3 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein PRK PF00485.18 EEA07727.1 - 0.0041 16.9 1.4 0.0085 15.9 0.8 1.9 1 1 1 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 EEA07727.1 - 0.0049 17.4 0.6 0.0073 16.8 0.6 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA07727.1 - 0.0065 16.9 0.0 0.014 15.8 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 EEA07727.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain CPT PF07931.12 EEA07727.1 - 0.014 15.2 0.1 0.04 13.8 0.1 1.7 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.6 EEA07727.1 - 0.021 15.0 0.1 0.069 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EEA07727.1 - 0.025 14.5 1.1 0.25 11.2 0.1 2.2 1 1 0 2 2 2 0 Rad17 P-loop domain AAA_29 PF13555.6 EEA07727.1 - 0.026 14.3 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.23 EEA07727.1 - 0.043 13.9 0.5 0.1 12.6 0.5 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain dNK PF01712.19 EEA07727.1 - 0.081 12.8 7.9 0.5 10.2 7.9 2.3 1 1 0 1 1 1 0 Deoxynucleoside kinase SRP54 PF00448.22 EEA07727.1 - 0.096 12.3 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 EEA07727.1 - 0.14 12.6 0.2 2.3 8.6 0.2 2.2 1 1 0 1 1 1 0 AAA domain SKI PF01202.22 EEA07727.1 - 0.19 11.8 3.3 6.2 6.9 0.0 2.4 2 1 0 2 2 2 0 Shikimate kinase ABC_tran PF00005.27 EEA07727.1 - 0.3 11.6 2.1 0.92 10.0 2.2 2.0 1 1 0 1 1 1 0 ABC transporter RRM_1 PF00076.22 EEA07728.1 - 1.1e-06 28.4 0.0 5.7e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AChE_tetra PF08674.10 EEA07728.1 - 0.069 12.9 2.1 0.21 11.3 2.1 1.8 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain RRP36 PF06102.12 EEA07728.1 - 0.13 12.2 0.8 0.26 11.2 0.8 1.4 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 OGG_N PF07934.12 EEA07728.1 - 7.6 6.7 8.8 0.52 10.4 1.0 2.6 2 1 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain Hydrolase_4 PF12146.8 EEA07729.1 - 2.7e-11 43.2 0.0 1.5e-07 30.9 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 PhoPQ_related PF10142.9 EEA07729.1 - 2.3e-09 36.4 0.5 1.4e-08 33.9 0.1 2.0 2 0 0 2 2 2 1 PhoPQ-activated pathogenicity-related protein Abhydrolase_1 PF00561.20 EEA07729.1 - 7.4e-09 35.6 1.5 0.00036 20.2 0.1 3.1 2 1 1 3 3 3 3 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EEA07729.1 - 8.7e-09 35.4 0.8 5.4e-06 26.2 0.2 2.6 2 1 0 3 3 3 2 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 EEA07729.1 - 5.8e-06 26.1 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EEA07729.1 - 0.00039 21.1 0.0 0.00055 20.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EEA07729.1 - 0.00055 19.5 0.1 0.0066 15.9 0.1 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EEA07729.1 - 0.004 17.1 0.0 0.011 15.7 0.0 1.7 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Rcd1 PF04078.13 EEA07729.1 - 0.0051 16.1 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like AXE1 PF05448.12 EEA07729.1 - 0.074 11.7 0.0 0.27 9.9 0.0 1.9 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DLH PF01738.18 EEA07729.1 - 0.099 12.2 0.1 0.99 8.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Atg14 PF10186.9 EEA07729.1 - 0.1 11.7 2.2 0.86 8.6 1.3 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HSP70 PF00012.20 EEA07730.1 - 4.4e-255 847.5 12.1 5e-255 847.3 12.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA07730.1 - 1.1e-19 70.4 1.7 1.3e-18 67.0 0.9 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EEA07730.1 - 0.0029 18.0 5.7 0.14 12.6 0.1 3.8 3 2 0 3 3 3 1 Cell division protein FtsA DUF1894 PF08979.11 EEA07730.1 - 0.024 15.0 0.0 0.26 11.7 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1894) Hydantoinase_A PF01968.18 EEA07730.1 - 0.034 13.4 0.1 1.8 7.8 0.1 2.7 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DNA_primase_S PF01896.19 EEA07730.1 - 0.085 12.9 0.1 15 5.6 0.0 2.6 2 0 0 2 2 2 0 DNA primase small subunit StbA PF06406.11 EEA07730.1 - 0.62 9.3 4.0 0.39 9.9 0.3 2.5 2 1 0 2 2 2 0 StbA protein DUF357 PF04010.13 EEA07730.1 - 1.9 8.6 3.7 67 3.7 0.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF357) ATG16 PF08614.11 EEA07731.1 - 2e-05 24.9 12.4 0.00014 22.1 12.4 1.9 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 EEA07731.1 - 0.00046 17.9 4.7 0.00054 17.6 4.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Myosin_tail_1 PF01576.19 EEA07731.1 - 0.001 17.0 7.0 0.0012 16.8 7.0 1.0 1 0 0 1 1 1 1 Myosin tail Spc7 PF08317.11 EEA07731.1 - 0.0019 17.1 6.9 0.0023 16.9 6.9 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Fez1 PF06818.15 EEA07731.1 - 0.0065 16.9 10.0 0.35 11.3 6.4 2.1 2 0 0 2 2 2 1 Fez1 DUF3450 PF11932.8 EEA07731.1 - 0.0077 15.6 6.3 0.0077 15.6 6.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) HMMR_N PF15905.5 EEA07731.1 - 0.012 15.1 11.9 0.016 14.7 11.9 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF4763 PF15960.5 EEA07731.1 - 0.02 14.2 10.8 0.034 13.5 1.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) MIP-T3_C PF17749.1 EEA07731.1 - 0.029 14.3 9.7 0.07 13.1 9.6 1.7 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region L27_1 PF09058.10 EEA07731.1 - 0.03 14.3 5.7 0.047 13.7 0.2 2.9 2 1 0 2 2 2 0 L27_1 Exo84_C PF16528.5 EEA07731.1 - 0.036 13.9 5.6 0.047 13.5 5.6 1.1 1 0 0 1 1 1 0 Exocyst component 84 C-terminal Baculo_PEP_C PF04513.12 EEA07731.1 - 0.045 13.8 3.4 0.063 13.3 3.4 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BST2 PF16716.5 EEA07731.1 - 0.055 14.0 8.0 0.089 13.4 8.0 1.3 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 SlyX PF04102.12 EEA07731.1 - 0.065 13.9 8.0 0.24 12.0 3.2 2.4 1 1 1 2 2 2 0 SlyX Exonuc_VII_L PF02601.15 EEA07731.1 - 0.08 12.5 3.9 0.075 12.6 3.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 EEA07731.1 - 0.1 11.5 6.5 0.12 11.2 6.6 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein Med9 PF07544.13 EEA07731.1 - 0.1 12.7 14.1 0.055 13.6 9.9 2.4 2 1 0 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 FapA PF03961.13 EEA07731.1 - 0.12 11.0 9.3 0.15 10.7 9.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tropomyosin_1 PF12718.7 EEA07731.1 - 0.12 12.5 11.9 0.48 10.6 11.5 2.0 1 1 1 2 2 2 0 Tropomyosin like BRE1 PF08647.11 EEA07731.1 - 0.13 12.4 13.0 0.22 11.6 13.0 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF16 PF01519.16 EEA07731.1 - 0.13 12.7 9.0 0.23 11.9 9.0 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1664 PF07889.12 EEA07731.1 - 0.14 12.2 4.9 0.23 11.5 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Cep57_CLD_2 PF14197.6 EEA07731.1 - 0.15 12.1 6.0 1.4 9.0 4.1 2.7 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Laminin_II PF06009.12 EEA07731.1 - 0.18 11.9 7.4 0.3 11.1 7.4 1.4 1 0 0 1 1 1 0 Laminin Domain II APG6_N PF17675.1 EEA07731.1 - 0.18 12.4 11.2 0.28 11.7 11.2 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region XhlA PF10779.9 EEA07731.1 - 0.29 11.4 10.7 0.67 10.2 3.5 2.6 1 1 1 2 2 2 0 Haemolysin XhlA DUF745 PF05335.13 EEA07731.1 - 0.29 10.9 2.9 0.35 10.6 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) ZapB PF06005.12 EEA07731.1 - 0.51 10.8 15.1 0.13 12.7 4.2 3.3 2 1 1 3 3 3 0 Cell division protein ZapB Fib_alpha PF08702.10 EEA07731.1 - 0.52 10.5 10.3 0.81 9.9 10.3 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4140 PF13600.6 EEA07731.1 - 0.57 10.6 2.9 2.1 8.8 2.9 1.9 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TMF_DNA_bd PF12329.8 EEA07731.1 - 0.62 10.1 15.1 2.9 7.9 10.2 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Csm1_N PF18504.1 EEA07731.1 - 0.66 10.3 11.3 0.76 10.2 3.9 3.0 1 1 2 3 3 3 0 Csm1 N-terminal domain Atg14 PF10186.9 EEA07731.1 - 0.76 8.8 11.4 2 7.4 11.8 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Swi5 PF07061.11 EEA07731.1 - 0.88 9.7 12.6 1.3 9.1 3.3 2.6 2 1 1 3 3 3 0 Swi5 FAM76 PF16046.5 EEA07731.1 - 0.91 8.8 8.3 1.1 8.5 8.3 1.1 1 0 0 1 1 1 0 FAM76 protein cwf21 PF08312.12 EEA07731.1 - 1.1 9.5 6.0 0.49 10.6 1.1 2.6 3 1 0 3 3 2 0 cwf21 domain GIT_CC PF16559.5 EEA07731.1 - 1.1 9.2 9.9 5.4 7.0 4.1 2.7 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FlxA PF14282.6 EEA07731.1 - 1.1 9.2 14.5 0.84 9.7 10.7 2.3 1 1 1 2 2 2 0 FlxA-like protein DUF4665 PF15679.5 EEA07731.1 - 2.5 8.8 11.3 1.9 9.1 6.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) DivIC PF04977.15 EEA07731.1 - 3.1 7.6 10.5 1.2 9.0 5.3 2.4 1 1 1 2 2 2 0 Septum formation initiator Sec2p PF06428.11 EEA07731.1 - 3.4 7.7 13.7 6.6 6.8 6.6 2.3 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p ABC_tran_CTD PF16326.5 EEA07731.1 - 4.6 7.6 10.2 1.9 8.8 4.6 2.8 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF4094 PF13334.6 EEA07731.1 - 5 7.6 8.1 19 5.8 3.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) YabA PF06156.13 EEA07731.1 - 5.1 7.8 10.7 1.7 9.3 3.1 2.3 1 1 1 2 2 2 0 Initiation control protein YabA DUF2672 PF10878.8 EEA07732.1 - 0.019 14.9 0.1 0.057 13.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2672) GRASP55_65 PF04495.14 EEA07733.1 - 3.5e-34 118.1 0.1 1.5e-26 93.4 0.0 2.7 2 1 1 3 3 3 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EEA07733.1 - 0.048 13.5 0.0 0.58 10.0 0.0 2.4 2 0 0 2 2 2 0 PDZ domain ComS PF17584.2 EEA07733.1 - 0.095 12.2 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 Bacillus competence protein S EMP70 PF02990.16 EEA07734.1 - 1e-115 387.4 28.8 1e-115 387.4 28.8 1.5 1 1 0 1 1 1 1 Endomembrane protein 70 Ribosomal_L18A PF01775.17 EEA07735.1 - 1e-47 161.2 0.7 1.3e-47 160.9 0.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF5494 PF17598.2 EEA07735.1 - 0.09 12.9 0.4 0.27 11.4 0.1 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5494) GLE1 PF07817.13 EEA07736.1 - 2.8e-26 92.3 3.9 2.2e-24 86.1 3.9 2.6 1 1 0 1 1 1 1 GLE1-like protein LCCL PF03815.19 EEA07737.1 - 2.1e-17 63.0 4.3 2.8e-17 62.6 0.0 2.8 2 0 0 2 2 2 1 LCCL domain F5_F8_type_C PF00754.25 EEA07737.1 - 8.9e-14 51.7 0.1 2.3e-08 34.2 0.0 2.7 2 0 0 2 2 2 2 F5/8 type C domain Rad21_Rec8_N PF04825.13 EEA07738.1 - 1.1e-18 67.3 0.2 4e-18 65.6 0.2 1.9 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EEA07738.1 - 2.9e-07 29.7 0.0 6.1e-07 28.6 0.0 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Glycophorin_A PF01102.18 EEA07738.1 - 0.095 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Glycophorin A Pkinase PF00069.25 EEA07739.1 - 1.4e-60 204.9 0.0 1.8e-60 204.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07739.1 - 3.2e-30 105.3 0.0 4.6e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA07739.1 - 0.057 12.7 0.0 0.14 11.4 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Amino_oxidase PF01593.24 EEA07740.1 - 8.3e-24 84.7 0.0 1.2e-20 74.3 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EEA07740.1 - 2.4e-07 30.3 0.0 3.7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA07740.1 - 3.3e-05 23.2 0.5 4.7e-05 22.7 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EEA07740.1 - 8.4e-05 22.7 0.0 0.0002 21.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EEA07740.1 - 0.00011 21.1 0.1 0.00018 20.3 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EEA07740.1 - 0.00018 21.2 0.0 0.00039 20.1 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EEA07740.1 - 0.00062 19.1 0.1 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 EEA07740.1 - 0.00086 18.5 1.6 0.0024 17.0 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EEA07740.1 - 0.002 17.4 0.1 0.0035 16.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EEA07740.1 - 0.003 16.9 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EEA07740.1 - 0.0082 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EEA07740.1 - 0.0087 15.3 0.3 0.024 13.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FYVE PF01363.21 EEA07740.1 - 0.01 16.0 1.6 0.01 16.0 1.6 3.0 3 0 0 3 3 2 0 FYVE zinc finger 3HCDH_N PF02737.18 EEA07740.1 - 0.019 14.8 0.0 0.043 13.7 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EEA07740.1 - 0.11 13.0 0.1 0.11 13.0 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EEA07740.1 - 0.15 11.4 0.1 0.37 10.1 0.3 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Me-amine-dh_L PF02975.14 EEA07740.1 - 0.47 11.0 10.1 0.61 10.6 6.1 2.7 1 1 1 2 2 2 0 Methylamine dehydrogenase, L chain VIT1 PF01988.19 EEA07741.1 - 1.1e-46 159.5 0.1 1.3e-46 159.2 0.1 1.1 1 0 0 1 1 1 1 VIT family COesterase PF00135.28 EEA07741.1 - 0.036 13.0 0.0 0.047 12.5 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family UTP25 PF06862.12 EEA07742.1 - 9.6e-105 351.1 0.0 1.5e-104 350.4 0.0 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF166 PF02593.14 EEA07742.1 - 0.022 14.3 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function SAM_KSR1 PF13543.6 EEA07743.1 - 0.0048 17.0 1.5 0.0048 17.0 1.5 1.8 2 0 0 2 2 2 1 SAM like domain present in kinase suppressor RAS 1 Oxidoreduct_C PF16490.5 EEA07743.1 - 0.056 13.1 0.5 0.089 12.5 0.5 1.3 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain HrcA_DNA-bdg PF03444.15 EEA07743.1 - 0.34 10.6 3.3 6.8 6.4 0.5 2.7 2 1 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding RNase_PH PF01138.21 EEA07744.1 - 3.7e-15 56.6 0.3 5.8e-15 56.0 0.3 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Ras PF00071.22 EEA07745.1 - 2e-50 170.6 0.0 2.4e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07745.1 - 2.8e-31 108.2 0.0 7.5e-31 106.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA07745.1 - 6e-12 45.4 0.0 7.5e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA07745.1 - 0.00011 22.2 0.0 0.00024 21.1 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA07745.1 - 0.0007 19.5 0.0 0.59 10.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase RNA_helicase PF00910.22 EEA07745.1 - 0.0015 18.9 0.2 0.013 15.9 0.2 2.2 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 EEA07745.1 - 0.0091 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA07745.1 - 0.013 15.0 0.5 0.098 12.2 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ArgoMid PF16487.5 EEA07745.1 - 0.017 15.3 0.1 0.029 14.6 0.1 1.4 1 0 0 1 1 1 0 Mid domain of argonaute NB-ARC PF00931.22 EEA07745.1 - 0.027 13.7 0.1 0.047 12.9 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 EEA07745.1 - 0.031 14.7 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EEA07745.1 - 0.052 14.1 0.2 0.23 12.0 0.0 1.9 2 1 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 EEA07745.1 - 0.07 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EEA07745.1 - 0.12 11.5 0.1 8.2 5.5 0.1 2.7 2 1 1 3 3 3 0 G-protein alpha subunit AAA_24 PF13479.6 EEA07745.1 - 0.13 12.0 0.1 0.19 11.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA07745.1 - 0.19 12.0 0.1 0.71 10.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain FKBP_C PF00254.28 EEA07746.1 - 4.6e-26 91.0 0.0 9.1e-26 90.0 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase OTU PF02338.19 EEA07747.1 - 0.00017 22.0 0.3 0.0038 17.7 0.0 2.9 2 1 0 2 2 2 1 OTU-like cysteine protease Dynamitin PF04912.14 EEA07748.1 - 2.3e-30 106.2 22.8 5.6e-30 104.9 22.8 1.6 1 1 0 1 1 1 1 Dynamitin Bcr-Abl_Oligo PF09036.10 EEA07748.1 - 0.012 15.6 1.8 6 7.0 0.2 3.4 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain GM_CSF PF01109.17 EEA07748.1 - 0.03 14.5 0.4 0.3 11.3 0.1 2.7 2 2 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor SpoOE-like PF09388.10 EEA07748.1 - 0.032 14.1 1.2 0.18 11.8 0.1 2.8 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein YojJ PF10372.9 EEA07748.1 - 0.055 13.6 1.1 0.055 13.6 1.1 3.8 4 1 0 4 4 4 0 Bacterial membrane-spanning protein N-terminus ABC_tran_CTD PF16326.5 EEA07748.1 - 0.11 12.7 11.7 2.3 8.5 0.1 4.5 3 2 1 4 4 4 0 ABC transporter C-terminal domain LOH1CR12 PF10158.9 EEA07748.1 - 0.27 11.3 10.2 5.4 7.0 0.8 4.0 3 1 0 3 3 3 0 Tumour suppressor protein Peptidase_C11 PF03415.14 EEA07748.1 - 0.33 10.3 8.0 0.22 10.9 0.4 2.5 1 1 2 3 3 3 0 Clostripain family DUF2443 PF10398.9 EEA07748.1 - 0.95 9.6 14.0 0.4 10.8 0.4 4.6 5 1 0 5 5 5 0 Protein of unknown function (DUF2443) K-box PF01486.17 EEA07748.1 - 4.8 7.4 14.6 0.95 9.7 0.2 4.4 3 1 1 4 4 4 0 K-box region WD40 PF00400.32 EEA07750.1 - 2.5e-05 25.0 12.8 0.88 10.5 2.8 5.9 6 0 0 6 6 6 2 WD domain, G-beta repeat WD40_like PF17005.5 EEA07750.1 - 3.1e-05 23.5 12.8 0.0014 18.1 3.7 3.6 1 1 3 4 4 4 2 WD40-like domain MMS1_N PF10433.9 EEA07750.1 - 0.0051 15.5 1.3 5.2 5.6 0.0 3.2 1 1 1 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term IKI3 PF04762.12 EEA07750.1 - 0.084 10.9 0.0 0.16 10.0 0.0 1.5 1 1 0 1 1 1 0 IKI3 family Methyltransf_4 PF02390.17 EEA07751.1 - 3.9e-46 156.7 0.0 6.3e-46 156.0 0.0 1.3 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EEA07751.1 - 0.0013 19.4 0.0 0.0024 18.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EEA07751.1 - 0.0058 15.7 0.0 0.0078 15.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DOT1 PF08123.13 EEA07751.1 - 0.011 15.2 0.0 0.076 12.5 0.0 1.9 1 1 1 2 2 2 0 Histone methylation protein DOT1 MTS PF05175.14 EEA07751.1 - 0.015 14.8 0.0 0.025 14.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain MetW PF07021.12 EEA07751.1 - 0.017 14.7 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 EEA07751.1 - 0.019 15.7 0.0 0.053 14.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 EEA07751.1 - 0.076 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EEA07751.1 - 0.082 12.7 0.0 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EEA07751.1 - 0.082 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EEA07751.1 - 0.11 13.1 0.0 0.26 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EEA07751.1 - 0.14 12.1 0.0 0.28 11.2 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain SprT-like PF10263.9 EEA07753.1 - 5.8e-20 71.2 0.1 2.1e-19 69.4 0.1 2.0 1 0 0 1 1 1 1 SprT-like family CYTL1 PF15153.6 EEA07753.1 - 0.043 13.8 0.3 0.14 12.1 0.3 1.9 1 0 0 1 1 1 0 Cytokine-like protein 1 Zn_ribbon_SprT PF17283.2 EEA07753.1 - 0.79 9.7 5.1 0.69 9.9 3.2 2.0 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Ribosomal_S11 PF00411.19 EEA07754.1 - 5e-46 155.6 0.9 6.5e-46 155.3 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 cNMP_binding PF00027.29 EEA07755.1 - 6e-41 138.4 0.0 8.7e-21 73.8 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 EEA07755.1 - 0.12 12.1 0.0 0.34 10.7 0.0 1.8 1 0 0 1 1 1 0 Cupin domain Sortilin-Vps10 PF15902.5 EEA07756.1 - 9.5e-91 304.8 24.8 5.4e-47 160.6 0.8 2.5 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EEA07756.1 - 2.3e-39 135.5 0.6 4.4e-39 134.5 0.6 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EEA07756.1 - 0.022 14.7 18.4 3.3 8.1 0.2 7.3 9 0 0 9 9 9 0 BNR/Asp-box repeat BNR_2 PF13088.6 EEA07756.1 - 0.028 13.7 0.1 1.9 7.7 0.0 2.9 3 0 0 3 3 3 0 BNR repeat-like domain UCR_UQCRX_QCR9 PF05365.12 EEA07756.1 - 0.037 14.0 1.9 0.36 10.8 0.2 3.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like BNR_6 PF15899.5 EEA07756.1 - 0.22 11.7 0.1 0.22 11.7 0.1 4.1 4 0 0 4 4 4 0 BNR-Asp box repeat BNR_3 PF13859.6 EEA07756.1 - 0.22 10.8 3.2 0.26 10.5 0.1 2.5 3 0 0 3 3 3 0 BNR repeat-like domain zf-RING_UBOX PF13445.6 EEA07757.1 - 1.6e-06 28.0 8.8 1.6e-06 28.0 8.8 4.3 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EEA07757.1 - 2.3e-06 27.3 14.4 2.3e-06 27.3 14.4 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA07757.1 - 4.5e-06 26.4 10.4 4.5e-06 26.4 10.4 4.2 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA07757.1 - 1.9e-05 24.4 13.5 1.9e-05 24.4 13.5 4.6 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA07757.1 - 2.9e-05 24.2 12.2 2.9e-05 24.2 12.2 4.9 5 2 2 7 7 7 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EEA07757.1 - 3.9e-05 23.5 11.8 3.9e-05 23.5 11.8 4.1 4 1 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.6 EEA07757.1 - 0.00051 20.3 13.0 0.00051 20.3 13.0 4.1 3 1 1 4 4 4 1 Ring finger domain U-box PF04564.15 EEA07757.1 - 0.53 10.5 2.6 0.61 10.3 0.2 2.4 3 0 0 3 3 3 0 U-box domain Sulfate_transp PF00916.20 EEA07758.1 - 1.3e-53 182.2 25.1 6.6e-35 120.6 15.2 2.3 2 0 0 2 2 2 2 Sulfate permease family STAS PF01740.21 EEA07758.1 - 5.1e-09 35.8 2.8 5.2e-08 32.5 2.8 2.5 1 1 0 1 1 1 1 STAS domain DUF4027 PF13219.6 EEA07758.1 - 0.074 12.9 0.3 9.8 6.1 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4027) AzlD PF05437.12 EEA07758.1 - 2.5 8.4 7.3 25 5.1 0.2 3.8 3 1 1 4 4 4 0 Branched-chain amino acid transport protein (AzlD) ATP_bind_1 PF03029.17 EEA07759.1 - 7.6e-72 242.0 0.0 8.6e-72 241.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EEA07759.1 - 0.00028 21.0 0.1 0.0056 16.8 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EEA07759.1 - 0.0018 18.0 0.0 0.0028 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EEA07759.1 - 0.0038 17.0 0.0 0.0053 16.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA07759.1 - 0.0058 16.8 0.0 0.0071 16.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EEA07759.1 - 0.011 16.1 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 EEA07759.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Septin PF00735.18 EEA07759.1 - 0.02 14.2 0.1 0.037 13.3 0.1 1.4 1 0 0 1 1 1 0 Septin Sigma54_activat PF00158.26 EEA07759.1 - 0.021 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 EEA07759.1 - 0.022 14.7 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EEA07759.1 - 0.027 14.8 0.0 0.27 11.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EEA07759.1 - 0.027 15.0 0.0 0.062 13.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EEA07759.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EEA07759.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EEA07759.1 - 0.15 12.4 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EEA07759.1 - 0.16 11.4 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EEA07759.1 - 0.17 11.8 0.7 1.3 8.9 0.0 2.5 3 0 0 3 3 3 0 NTPase AAA_23 PF13476.6 EEA07759.1 - 0.2 12.2 1.8 0.75 10.3 1.8 2.3 1 1 0 1 1 1 0 AAA domain zf-C3HC4_3 PF13920.6 EEA07760.1 - 6.5e-12 45.1 10.0 4e-11 42.6 4.5 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA07760.1 - 0.00017 21.8 4.6 0.00017 21.8 4.6 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA07760.1 - 0.00065 19.5 5.1 0.00065 19.5 5.1 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA07760.1 - 0.00084 19.2 4.1 0.00084 19.2 4.1 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA07760.1 - 0.01 15.7 5.6 0.01 15.7 5.6 2.6 3 0 0 3 3 3 0 zinc-RING finger domain DUF1514 PF07438.11 EEA07760.1 - 0.017 15.0 4.8 0.071 13.0 3.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) zinc-ribbons_6 PF07191.12 EEA07760.1 - 2 8.4 8.0 0.22 11.5 2.2 2.3 2 0 0 2 2 2 0 zinc-ribbons Hat1_N PF10394.9 EEA07761.1 - 3.4e-14 53.4 2.2 9.3e-14 52.0 2.2 1.7 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.7 EEA07761.1 - 0.0021 18.0 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EEA07761.1 - 0.0063 16.7 0.0 0.017 15.3 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA07761.1 - 0.0076 16.7 0.0 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_22 PF13401.6 EEA07761.1 - 0.019 15.2 0.1 0.043 14.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain Synaptobrevin PF00957.21 EEA07762.1 - 6.4e-12 45.1 1.5 6.4e-12 45.1 1.5 2.1 1 1 1 2 2 2 1 Synaptobrevin DUF2207 PF09972.9 EEA07762.1 - 0.012 14.4 1.2 0.014 14.2 1.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Sec20 PF03908.13 EEA07762.1 - 0.02 14.8 4.6 0.02 14.8 4.6 2.1 2 1 0 2 2 2 0 Sec20 RIFIN PF02009.16 EEA07762.1 - 0.031 14.2 0.2 0.049 13.5 0.2 1.3 1 0 0 1 1 1 0 Rifin Presenilin PF01080.17 EEA07762.1 - 0.034 12.9 1.6 0.036 12.8 1.6 1.2 1 0 0 1 1 1 0 Presenilin Pex24p PF06398.11 EEA07762.1 - 0.038 13.0 0.6 0.044 12.8 0.6 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Cir_Bir_Yir PF06022.11 EEA07762.1 - 0.063 12.8 4.9 0.13 11.7 4.9 1.5 1 1 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir MPS-4 PF17523.2 EEA07762.1 - 0.1 12.7 3.2 0.18 11.9 3.2 1.5 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 TctA PF01970.16 EEA07762.1 - 0.11 11.2 3.8 0.13 10.9 3.8 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family Halogen_Hydrol PF10112.9 EEA07762.1 - 0.15 12.1 4.7 0.95 9.4 0.9 2.2 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein MAP17 PF15807.5 EEA07762.1 - 2.7 8.2 4.3 2.1 8.6 2.7 1.6 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Ank_2 PF12796.7 EEA07764.1 - 5.7e-31 107.0 5.6 3.8e-14 53.0 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA07764.1 - 5.2e-28 97.1 6.7 4.4e-15 55.8 0.0 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA07764.1 - 5.7e-24 81.6 1.8 6e-07 29.3 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EEA07764.1 - 5e-22 77.7 3.7 6.3e-13 48.7 0.1 3.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA07764.1 - 2.8e-20 71.8 9.7 1.4e-05 25.3 0.1 5.7 6 0 0 6 6 6 4 Ankyrin repeat SPACA9 PF15120.6 EEA07764.1 - 0.11 12.2 1.0 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 Rick_17kDa_Anti PF05433.15 EEA07767.1 - 0.032 14.1 7.8 0.14 12.1 0.4 2.2 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EEA07767.1 - 0.04 13.9 11.7 0.064 13.3 11.7 1.2 1 0 0 1 1 1 0 Glycine zipper DUF1269 PF06897.12 EEA07767.1 - 0.045 14.0 0.9 0.14 12.5 0.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Romo1 PF10247.9 EEA07767.1 - 0.046 14.1 0.2 0.046 14.1 0.2 2.2 1 1 1 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Gly-zipper_OmpA PF13436.6 EEA07767.1 - 0.45 10.3 12.0 0.6 9.9 12.0 1.2 1 0 0 1 1 1 0 Glycine-zipper domain Bacteriocin_IIc PF10439.9 EEA07767.1 - 0.74 10.0 9.4 1.3 9.2 9.4 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide YtxH PF12732.7 EEA07767.1 - 1 9.9 4.3 7.1 7.3 0.0 3.0 2 0 0 2 2 2 0 YtxH-like protein Gly-zipper_YMGG PF13441.6 EEA07767.1 - 8.7 6.2 14.3 13 5.6 14.3 1.2 1 0 0 1 1 1 0 YMGG-like Gly-zipper DUF726 PF05277.12 EEA07768.1 - 8e-91 304.5 3.2 1.2e-90 303.9 3.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Cutinase PF01083.22 EEA07768.1 - 0.039 13.9 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Cutinase Thioesterase PF00975.20 EEA07768.1 - 0.19 11.8 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain FAD_binding_1 PF00667.20 EEA07769.1 - 3.6e-27 95.4 0.0 9.9e-26 90.7 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 EEA07769.1 - 9.9e-17 61.5 0.0 2e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin Bromodomain PF00439.25 EEA07770.1 - 2e-27 95.0 7.1 3.8e-17 62.1 0.5 3.0 2 0 0 2 2 2 2 Bromodomain RCC1 PF00415.18 EEA07771.1 - 5e-39 132.7 9.1 6.6e-07 29.9 0.0 9.4 8 2 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA07771.1 - 1.1e-23 82.5 39.9 3e-08 33.3 1.1 8.1 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat LAT PF15234.6 EEA07771.1 - 3.3 7.4 6.7 0.73 9.5 2.7 1.9 2 0 0 2 2 2 0 Linker for activation of T-cells zf-C3HC4_3 PF13920.6 EEA07772.1 - 6.8e-13 48.3 8.6 1.4e-12 47.3 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA07772.1 - 4.4e-07 29.7 10.3 8.6e-07 28.7 10.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EEA07772.1 - 0.00012 22.4 13.0 0.0003 21.1 13.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EEA07772.1 - 0.0017 18.2 13.0 0.0036 17.1 13.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA07772.1 - 0.003 17.4 13.3 0.0064 16.3 13.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 EEA07772.1 - 1.2 9.2 8.0 14 5.7 5.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) zf-RING_4 PF14570.6 EEA07772.1 - 2.5 8.0 9.5 5.4 6.9 9.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1825 PF08855.10 EEA07773.1 - 0.0021 17.9 0.2 0.0037 17.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1825) ABC_tran PF00005.27 EEA07774.1 - 1.5e-15 57.9 0.0 1.6e-08 35.2 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ATPase_2 PF01637.18 EEA07774.1 - 0.0074 16.2 0.1 0.028 14.3 0.1 2.0 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EEA07774.1 - 0.0074 16.7 0.0 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EEA07774.1 - 0.029 14.9 0.0 0.099 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EEA07774.1 - 0.034 14.0 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EEA07774.1 - 0.042 14.1 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EEA07774.1 - 0.1 12.3 0.0 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EEA07774.1 - 0.1 12.4 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 EEA07774.1 - 0.13 12.1 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PFU PF09070.11 EEA07774.1 - 0.14 12.5 0.0 0.42 10.9 0.0 1.8 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) SieB PF14163.6 EEA07774.1 - 2.2 7.7 6.9 0.25 10.8 1.1 2.4 2 0 0 2 2 2 0 Super-infection exclusion protein B ABC_tran PF00005.27 EEA07775.1 - 8.9e-19 68.4 0.0 2.9e-09 37.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ATPase_2 PF01637.18 EEA07775.1 - 0.0035 17.3 0.2 1.7 8.5 0.0 2.7 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 EEA07775.1 - 0.02 15.0 0.4 6 7.0 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 EEA07775.1 - 0.027 13.9 3.5 2.7 7.4 0.0 3.6 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EEA07775.1 - 0.033 14.6 0.1 0.97 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EEA07775.1 - 0.034 13.9 0.1 4.6 7.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EEA07775.1 - 0.035 13.7 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EEA07775.1 - 0.062 13.8 6.8 1.4 9.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EEA07775.1 - 0.12 12.9 1.1 9.6 6.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 EEA07775.1 - 0.37 10.6 3.2 2.3 8.0 0.0 3.5 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EEA07776.1 - 2.9e-17 63.4 0.0 5.1e-08 33.5 0.0 2.8 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EEA07776.1 - 4.2e-07 30.1 2.9 0.026 14.4 0.0 4.0 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA07776.1 - 0.00022 20.9 1.1 0.88 9.4 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EEA07776.1 - 0.0006 19.3 0.0 0.41 10.0 0.0 2.7 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EEA07776.1 - 0.00062 20.3 5.2 0.0078 16.7 0.1 3.4 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EEA07776.1 - 0.0011 19.2 0.1 1.8 8.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Roc PF08477.13 EEA07776.1 - 0.002 18.4 1.3 0.16 12.2 0.1 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EEA07776.1 - 0.007 16.4 1.8 1.4 9.0 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EEA07776.1 - 0.0074 15.7 0.9 1.7 7.9 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_16 PF13191.6 EEA07776.1 - 0.013 15.9 0.0 9.4 6.6 0.2 2.3 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 EEA07776.1 - 0.017 15.1 0.3 1.8 8.4 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EEA07776.1 - 0.031 13.8 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EEA07776.1 - 0.034 14.1 1.0 2.8 7.8 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_15 PF13175.6 EEA07776.1 - 0.1 12.3 17.7 0.24 11.1 0.5 3.3 2 1 0 2 2 2 0 AAA ATPase domain Pox_A14 PF05767.12 EEA07776.1 - 1.6 9.0 15.6 8.9 6.5 1.4 5.3 4 0 0 4 4 4 0 Poxvirus virion envelope protein A14 Pyrophosphatase PF00719.19 EEA07777.1 - 1e-42 145.7 0.0 1.6e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF4199 PF13858.6 EEA07778.1 - 0.0087 16.5 1.9 0.014 15.8 1.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4199) N2227 PF07942.12 EEA07779.1 - 2.4e-89 299.2 0.1 7.4e-89 297.5 0.0 1.8 2 0 0 2 2 2 1 N2227-like protein TAP42 PF04177.12 EEA07780.1 - 3.3e-62 210.5 4.9 3.8e-62 210.3 4.9 1.0 1 0 0 1 1 1 1 TAP42-like family DUF3139 PF11337.8 EEA07783.1 - 0.012 16.2 0.8 0.017 15.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) O-antigen_lig PF13425.6 EEA07783.1 - 0.081 11.7 0.4 0.08 11.7 0.4 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein AP-5_subunit_s1 PF15001.6 EEA07783.1 - 0.097 12.7 0.1 0.11 12.4 0.1 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 V_ATPase_I PF01496.19 EEA07784.1 - 3.8e-263 875.2 3.0 4.5e-263 875.0 3.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF2779 PF11074.8 EEA07784.1 - 0.029 14.8 2.6 4.3 7.8 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function(DUF2779) RIBIOP_C PF04950.12 EEA07785.1 - 1e-75 254.9 0.4 1e-75 254.9 0.4 2.9 3 0 0 3 3 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EEA07785.1 - 9.7e-26 89.7 0.0 4.2e-25 87.6 0.0 2.2 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EEA07785.1 - 6.9e-06 25.7 0.1 0.00015 21.3 0.0 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EEA07785.1 - 7.3e-05 23.0 1.7 0.00014 22.0 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_22 PF13401.6 EEA07785.1 - 0.00074 19.8 0.0 0.0019 18.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EEA07785.1 - 0.00079 19.9 0.0 0.0023 18.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA07785.1 - 0.0012 19.2 0.0 0.0028 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EEA07785.1 - 0.0021 17.8 0.0 0.011 15.5 0.0 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EEA07785.1 - 0.0031 18.1 1.7 0.0052 17.3 0.0 2.3 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EEA07785.1 - 0.0032 17.2 0.1 0.0079 15.9 0.0 1.6 2 0 0 2 2 1 1 AAA domain MMR_HSR1 PF01926.23 EEA07785.1 - 0.0034 17.4 0.4 0.025 14.6 0.1 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 EEA07785.1 - 0.0036 16.9 0.0 0.0086 15.7 0.0 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EEA07785.1 - 0.0057 16.6 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_5 PF07728.14 EEA07785.1 - 0.013 15.5 0.0 0.033 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EEA07785.1 - 0.014 14.6 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Viral_helicase1 PF01443.18 EEA07785.1 - 0.015 15.1 0.0 0.038 13.7 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EEA07785.1 - 0.017 15.6 3.0 0.032 14.7 0.1 3.0 2 1 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 EEA07785.1 - 0.023 14.6 0.1 0.059 13.3 0.1 1.7 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 EEA07785.1 - 0.024 14.6 0.1 0.18 11.7 0.0 2.3 1 1 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 EEA07785.1 - 0.031 14.7 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EEA07785.1 - 0.039 14.3 0.0 0.089 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EEA07785.1 - 0.046 13.8 2.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EEA07785.1 - 0.06 13.1 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EEA07785.1 - 0.086 12.4 0.0 0.28 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EEA07785.1 - 0.11 12.3 0.0 0.11 12.3 0.0 3.9 3 1 0 3 3 2 0 AAA domain DNA_primase_S PF01896.19 EEA07786.1 - 7.5e-55 185.7 2.5 1e-54 185.2 2.5 1.2 1 0 0 1 1 1 1 DNA primase small subunit PhoU_div PF01865.16 EEA07787.1 - 0.0026 17.1 0.5 0.0034 16.7 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF47 Prenyltransf PF01255.19 EEA07788.1 - 3.2e-55 187.1 0.1 3.9e-55 186.8 0.1 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PPI_Ypi1 PF07491.11 EEA07788.1 - 1.1 9.2 4.7 2.3 8.1 0.5 2.3 1 1 1 2 2 2 0 Protein phosphatase inhibitor Calcyon PF06387.11 EEA07789.1 - 0.019 14.9 0.3 0.022 14.8 0.3 1.0 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) E1-N PF14463.6 EEA07789.1 - 0.14 11.9 0.0 0.19 11.6 0.0 1.1 1 0 0 1 1 1 0 E1 N-terminal domain Brix PF04427.18 EEA07790.1 - 2.1e-36 125.8 0.1 2.9e-36 125.4 0.1 1.2 1 0 0 1 1 1 1 Brix domain Abhydrolase_1 PF00561.20 EEA07791.1 - 7.6e-12 45.4 0.1 1e-05 25.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EEA07791.1 - 1.6e-08 34.1 0.0 7.1e-05 22.2 0.0 2.3 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EEA07791.1 - 3.6e-05 23.7 0.1 0.00033 20.5 0.1 2.2 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EEA07791.1 - 0.00045 20.0 0.0 0.0008 19.1 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EEA07791.1 - 0.00098 18.7 0.0 0.0021 17.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF1749 PF08538.10 EEA07791.1 - 0.0057 15.8 0.1 0.01 15.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EEA07791.1 - 0.0094 16.6 0.0 1.1 9.9 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 EEA07791.1 - 0.061 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF818 PF05677.12 EEA07791.1 - 0.12 11.3 0.5 0.26 10.2 0.2 1.7 2 0 0 2 2 2 0 Chlamydia CHLPS protein (DUF818) RabGAP-TBC PF00566.18 EEA07793.1 - 2.4e-34 118.9 12.3 2.4e-34 118.9 12.3 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain F-box PF00646.33 EEA07793.1 - 0.031 14.2 1.3 5.2 7.1 0.0 2.8 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EEA07793.1 - 0.032 14.1 0.0 0.12 12.3 0.0 2.0 1 0 0 1 1 1 0 F-box-like Glyco_trans_2_3 PF13632.6 EEA07793.1 - 0.077 12.9 0.0 0.26 11.2 0.0 1.9 1 1 0 1 1 1 0 Glycosyl transferase family group 2 Inhibitor_G39P PF11417.8 EEA07793.1 - 0.13 12.8 2.4 17 6.0 0.1 3.5 3 0 0 3 3 3 0 Loader and inhibitor of phage G40P CAF1C_H4-bd PF12265.8 EEA07794.1 - 4.3e-22 78.1 0.3 2.9e-21 75.5 0.3 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EEA07794.1 - 3.3e-18 65.7 11.5 0.00014 22.6 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07794.1 - 0.00067 19.9 1.4 1.7 9.0 0.1 4.0 4 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4059 PF13268.6 EEA07794.1 - 0.16 12.4 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4059) Mog1 PF04603.12 EEA07795.1 - 2.3e-35 121.9 0.3 3.9e-35 121.2 0.3 1.3 1 0 0 1 1 1 1 Ran-interacting Mog1 protein zf-RING_2 PF13639.6 EEA07796.1 - 8.3e-13 48.5 6.3 2.3e-12 47.0 6.3 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EEA07796.1 - 1.2e-09 37.7 2.4 3.7e-09 36.1 2.4 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EEA07796.1 - 2.2e-09 37.4 4.6 5.8e-09 36.1 4.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EEA07796.1 - 4.2e-08 32.9 6.4 4.2e-08 32.9 6.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EEA07796.1 - 9.2e-07 28.8 2.2 3.4e-06 27.0 2.2 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA07796.1 - 4.5e-06 26.4 6.3 1.4e-05 24.9 6.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA07796.1 - 3.7e-05 23.6 4.5 0.00012 21.9 4.5 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA07796.1 - 3.8e-05 23.5 4.7 8.7e-05 22.3 4.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA07796.1 - 0.00019 21.4 0.7 0.00047 20.1 0.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EEA07796.1 - 0.0005 19.6 5.5 0.00077 19.0 4.0 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type CDC48_2 PF02933.17 EEA07796.1 - 0.0022 17.7 0.0 0.0047 16.7 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 zf-C3H2C3 PF17122.5 EEA07796.1 - 0.011 15.8 3.6 0.038 14.0 3.6 2.1 1 0 0 1 1 1 0 Zinc-finger BNIP2 PF12496.8 EEA07796.1 - 0.033 14.6 0.1 1.6 9.1 0.0 2.3 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 zf-C3HC4_4 PF15227.6 EEA07796.1 - 0.1 12.8 6.3 0.44 10.7 6.3 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EEA07796.1 - 0.12 12.3 9.2 0.028 14.3 5.7 1.9 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 zinc_ribbon_16 PF17034.5 EEA07796.1 - 0.15 12.2 3.0 0.21 11.8 0.9 2.1 1 1 1 2 2 2 0 Zinc-ribbon like family FANCL_C PF11793.8 EEA07796.1 - 0.25 11.6 5.1 0.84 9.9 5.1 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.14 EEA07796.1 - 0.77 9.5 5.3 2 8.2 5.3 1.7 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_10 PF16685.5 EEA07796.1 - 2.5 8.3 11.7 0.42 10.8 5.4 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING-like PF08746.11 EEA07796.1 - 2.6 8.4 9.1 0.71 10.2 5.5 2.0 2 0 0 2 2 2 0 RING-like domain RINGv PF12906.7 EEA07796.1 - 2.9 8.1 8.1 5.4 7.2 7.1 2.0 2 0 0 2 2 1 0 RING-variant domain PHD PF00628.29 EEA07796.1 - 6.8 6.7 12.1 0.96 9.4 5.2 2.8 3 0 0 3 3 3 0 PHD-finger RNA_pol_Rbc25 PF08292.12 EEA07797.1 - 2.1e-23 83.0 2.3 2.2e-18 66.8 0.0 2.4 1 1 1 2 2 2 2 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EEA07797.1 - 1.4e-08 35.0 0.1 2.2e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EEA07797.1 - 0.051 13.9 0.1 0.14 12.5 0.0 1.9 2 1 0 2 2 2 0 S1 RNA binding domain Tim17 PF02466.19 EEA07798.1 - 8.4e-18 64.8 2.5 1.3e-17 64.2 2.5 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family EspB PF05802.11 EEA07798.1 - 0.14 12.2 0.1 0.3 11.1 0.1 1.5 1 1 0 1 1 1 0 Enterobacterial EspB protein COPI_assoc PF08507.10 EEA07799.1 - 3.8e-05 23.8 6.3 5.6e-05 23.2 6.3 1.2 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.9 EEA07799.1 - 0.23 11.8 4.7 0.34 11.2 4.7 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein CG6151-P Prenyltrans PF00432.21 EEA07800.1 - 5e-33 112.5 14.4 3.4e-09 36.3 1.2 5.3 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat DUF2093 PF09866.9 EEA07800.1 - 0.034 13.6 4.8 0.069 12.6 1.7 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2093) Thg1 PF04446.12 EEA07801.1 - 1.9e-49 166.8 0.3 3.5e-49 166.0 0.3 1.4 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EEA07801.1 - 4.2e-41 139.9 2.5 6.7e-41 139.3 2.5 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain Utp14 PF04615.13 EEA07802.1 - 1.5e-57 195.8 34.1 3.6e-30 105.2 32.9 2.0 1 1 1 2 2 2 2 Utp14 protein DUF3734 PF12536.8 EEA07802.1 - 0.14 12.5 0.2 0.14 12.5 0.2 3.5 3 1 1 4 4 4 0 Patatin phospholipase DUF4094 PF13334.6 EEA07803.1 - 0.013 15.9 9.2 0.065 13.7 1.0 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) CaKB PF03185.15 EEA07803.1 - 0.02 14.6 0.1 0.055 13.1 0.1 1.7 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Helo_like_N PF17111.5 EEA07803.1 - 1.9 7.8 12.3 0.94 8.8 3.9 2.4 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins DUF883 PF05957.13 EEA07803.1 - 2.4 8.8 6.0 68 4.2 0.3 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DMPK_coil PF08826.10 EEA07803.1 - 3.1 8.0 8.9 0.87 9.7 1.3 2.8 2 0 0 2 2 2 0 DMPK coiled coil domain like CoA_binding_3 PF13727.6 EEA07804.1 - 0.073 13.1 0.1 0.082 12.9 0.1 1.1 1 0 0 1 1 1 0 CoA-binding domain TauE PF01925.19 EEA07806.1 - 9e-21 74.6 28.5 5.6e-10 39.3 10.4 3.2 2 1 1 3 3 3 3 Sulfite exporter TauE/SafE PuR_N PF09182.10 EEA07806.1 - 0.076 13.0 2.4 5.1 7.1 0.1 2.8 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal DUF2244 PF10003.9 EEA07806.1 - 0.1 12.3 0.1 0.1 12.3 0.1 3.5 4 0 0 4 4 4 0 Integral membrane protein (DUF2244) PK PF00224.21 EEA07807.1 - 2.1e-135 451.1 4.3 2.5e-134 447.6 2.2 2.0 2 0 0 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 EEA07807.1 - 4.1e-30 104.4 2.3 9.2e-30 103.3 2.3 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EEA07807.1 - 0.00017 20.8 0.1 0.00041 19.6 0.1 1.6 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family WD40 PF00400.32 EEA07808.1 - 3.2e-06 27.8 4.7 0.00097 19.9 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat Ras PF00071.22 EEA07809.1 - 2.4e-59 199.6 0.2 2.9e-59 199.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07809.1 - 9e-32 109.8 0.1 1.6e-31 109.0 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA07809.1 - 2.5e-12 46.6 0.0 3.3e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EEA07809.1 - 3.6e-05 23.8 0.0 6.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA07809.1 - 0.0029 17.5 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EEA07809.1 - 0.01 15.4 0.0 0.055 13.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain DNA_pol_E_B PF04042.16 EEA07809.1 - 0.02 14.2 0.0 0.028 13.8 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Gtr1_RagA PF04670.12 EEA07809.1 - 0.049 13.0 0.0 0.069 12.5 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region PWWP PF00855.17 EEA07810.1 - 0.00093 19.6 0.0 0.0027 18.1 0.0 1.8 2 0 0 2 2 2 1 PWWP domain Zn_ribbon_17 PF17120.5 EEA07811.1 - 0.04 13.5 0.5 0.04 13.5 0.5 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF2318 PF10080.9 EEA07811.1 - 0.13 12.4 7.8 4.2 7.5 2.1 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) DZR PF12773.7 EEA07811.1 - 0.19 11.7 0.3 0.19 11.7 0.3 2.5 2 0 0 2 2 2 0 Double zinc ribbon RhoGEF PF00621.20 EEA07811.1 - 1.3 9.2 7.0 1.7 8.8 1.0 2.3 1 1 0 2 2 2 0 RhoGEF domain Zf_RING PF16744.5 EEA07811.1 - 2 8.6 6.2 0.22 11.6 0.4 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger EF-hand_7 PF13499.6 EEA07812.1 - 1.7e-10 41.2 3.9 0.00028 21.3 1.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EEA07812.1 - 9.1e-09 34.3 8.6 0.0018 17.7 0.2 3.9 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 EEA07812.1 - 9.5e-09 34.4 5.2 6.8e-05 22.2 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EEA07812.1 - 3.7e-08 32.7 4.8 0.015 15.1 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EEA07812.1 - 2.5e-06 27.2 3.7 0.035 14.0 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA07812.1 - 0.0095 16.2 3.4 0.92 9.8 0.0 3.3 2 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.25 EEA07813.1 - 5.4e-10 39.1 0.3 5.7e-05 22.6 0.1 2.7 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07813.1 - 0.0012 18.2 0.0 0.13 11.6 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase HEAT PF02985.22 EEA07814.1 - 2.5e-15 55.3 3.3 0.1 12.9 0.0 9.7 9 0 0 9 9 9 5 HEAT repeat HEAT_2 PF13646.6 EEA07814.1 - 1.9e-05 25.0 0.0 15 6.1 0.0 5.1 4 1 0 4 4 4 3 HEAT repeats SGS PF05002.15 EEA07814.1 - 0.19 11.9 0.3 0.73 10.0 0.1 2.1 2 0 0 2 2 2 0 SGS domain tRNA-synt_1c PF00749.21 EEA07815.1 - 1.6e-102 342.7 0.1 2.8e-102 341.8 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EEA07815.1 - 3.3e-37 128.0 0.0 3.3e-36 124.8 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain DUF4698 PF15769.5 EEA07815.1 - 0.063 12.3 0.0 0.23 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4698) PI31_Prot_N PF11566.8 EEA07816.1 - 0.00063 19.6 1.0 0.0074 16.1 1.0 2.4 1 1 0 1 1 1 1 PI31 proteasome regulator N-terminal GYF PF02213.16 EEA07817.1 - 9.5e-08 31.6 0.1 1.8e-07 30.7 0.1 1.5 1 0 0 1 1 1 1 GYF domain BTB PF00651.31 EEA07817.1 - 0.0031 17.7 0.1 0.018 15.2 0.0 2.4 1 1 1 2 2 2 1 BTB/POZ domain GYF_2 PF14237.6 EEA07817.1 - 0.0051 16.6 0.0 0.0099 15.7 0.0 1.5 1 0 0 1 1 1 1 GYF domain 2 Baculo_p24 PF05073.12 EEA07817.1 - 0.077 12.8 2.3 0.12 12.2 0.7 2.1 2 1 0 2 2 2 0 Baculovirus P24 capsid protein GYF PF02213.16 EEA07818.1 - 1.1e-05 25.0 0.2 0.00015 21.3 0.2 2.7 3 0 0 3 3 3 1 GYF domain BTB PF00651.31 EEA07818.1 - 0.0064 16.7 0.0 0.035 14.3 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain SET PF00856.28 EEA07819.1 - 2.3e-09 37.8 0.3 4.4e-09 36.9 0.3 1.5 1 0 0 1 1 1 1 SET domain AAA PF00004.29 EEA07820.1 - 9.9e-35 119.8 0.0 2.6e-34 118.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA07820.1 - 2.7e-06 27.4 0.0 8.6e-06 25.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EEA07820.1 - 7.5e-06 25.8 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EEA07820.1 - 0.00014 22.0 0.0 0.0011 19.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EEA07820.1 - 0.00029 21.0 0.0 0.0015 18.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EEA07820.1 - 0.0011 19.2 1.6 0.36 11.1 0.0 3.8 3 1 1 4 4 4 1 AAA domain AAA_16 PF13191.6 EEA07820.1 - 0.0013 19.1 0.1 0.059 13.8 0.0 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EEA07820.1 - 0.0025 18.4 3.3 0.0079 16.7 0.2 3.2 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EEA07820.1 - 0.016 15.1 0.1 5.5 6.9 0.0 2.5 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.6 EEA07820.1 - 0.029 14.2 2.7 0.094 12.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EEA07820.1 - 0.053 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 EEA07820.1 - 0.059 13.6 0.0 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EEA07820.1 - 0.082 12.6 0.1 0.23 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EEA07820.1 - 0.084 12.6 0.0 7.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 EEA07820.1 - 0.094 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Na_H_Exchanger PF00999.21 EEA07821.1 - 1.6e-50 172.0 52.4 2.1e-50 171.6 52.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TIG PF01833.24 EEA07821.1 - 2.5e-11 43.5 5.8 0.00015 21.8 0.7 3.5 2 1 0 2 2 2 2 IPT/TIG domain Benyvirus_14KDa PF07255.11 EEA07821.1 - 0.42 10.8 2.2 29 4.9 0.0 3.0 2 1 0 2 2 2 0 Benyvirus 14KDa protein DEK_C PF08766.11 EEA07823.1 - 1.8e-07 31.0 3.6 1.8e-07 31.0 3.6 2.1 2 0 0 2 2 2 1 DEK C terminal domain PSD1 PF07587.11 EEA07823.1 - 0.041 13.4 0.7 0.053 13.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) AAA_11 PF13086.6 EEA07823.1 - 2.6 7.8 9.9 4.2 7.1 9.9 1.4 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 EEA07824.1 - 3e-29 100.7 39.3 1.5e-05 25.6 1.4 7.6 7 1 1 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07824.1 - 2.1e-10 40.8 3.8 0.079 13.3 0.0 5.0 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EEA07824.1 - 0.009 15.4 1.6 0.097 12.0 0.0 3.1 2 1 0 3 3 3 1 WD40-like domain Asp PF00026.23 EEA07825.1 - 4.5e-17 62.4 4.6 1.6e-16 60.6 4.6 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EEA07825.1 - 1.8e-16 60.9 1.1 5.7e-15 56.0 0.6 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EEA07825.1 - 6.7e-13 48.7 0.0 1.2e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EEA07825.1 - 0.1 13.2 0.0 33 5.1 0.0 3.0 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease LSM PF01423.22 EEA07826.1 - 7.1e-14 51.2 0.0 9.1e-14 50.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA07826.1 - 0.0038 17.3 0.0 0.007 16.5 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EEA07826.1 - 0.06 13.4 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Scd6-like Sm domain RNA_pol_Rpb8 PF03870.15 EEA07827.1 - 3.1e-40 137.6 0.1 3.4e-40 137.4 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EEA07827.1 - 3.8e-05 23.7 0.0 0.0013 18.8 0.0 2.0 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G Ribosomal_S26e PF01283.19 EEA07828.1 - 1.1e-48 164.1 11.4 1.2e-48 164.0 11.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e SRP19 PF01922.17 EEA07828.1 - 0.026 15.4 0.1 0.042 14.8 0.1 1.3 1 0 0 1 1 1 0 SRP19 protein DnaJ PF00226.31 EEA07829.1 - 2.2e-16 59.7 2.3 2.4e-16 59.6 0.2 2.1 2 0 0 2 2 2 1 DnaJ domain HD_3 PF13023.6 EEA07829.1 - 0.1 12.5 3.8 7.8 6.4 1.5 2.1 2 0 0 2 2 2 0 HD domain TarH PF02203.15 EEA07829.1 - 0.28 11.1 2.8 0.47 10.4 2.7 1.5 1 1 0 1 1 1 0 Tar ligand binding domain homologue DUF3450 PF11932.8 EEA07830.1 - 0.016 14.5 5.8 0.031 13.6 5.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SlyX PF04102.12 EEA07830.1 - 0.056 14.1 9.8 3.4 8.3 0.1 3.6 2 1 1 3 3 3 0 SlyX V_ATPase_I PF01496.19 EEA07830.1 - 0.14 10.0 9.7 0.23 9.3 9.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 EEA07830.1 - 0.2 10.5 15.6 0.37 9.6 15.6 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 EEA07830.1 - 0.62 9.9 11.3 0.68 9.7 8.1 2.8 1 1 2 3 3 3 0 Septum formation initiator Fzo_mitofusin PF04799.13 EEA07830.1 - 0.62 9.6 4.2 1.6 8.3 4.2 1.8 1 0 0 1 1 1 0 fzo-like conserved region Atg14 PF10186.9 EEA07830.1 - 0.63 9.1 20.4 0.33 10.0 17.1 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.21 EEA07830.1 - 0.83 9.2 19.2 4.9 6.6 19.2 2.1 1 1 0 1 1 1 0 Intermediate filament protein Cep57_MT_bd PF06657.13 EEA07830.1 - 1.2 9.7 10.4 1.9 9.0 2.9 2.6 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 PIN_8 PF18476.1 EEA07830.1 - 1.5 8.6 16.1 0.55 10.0 11.5 2.5 2 1 1 3 3 3 0 PIN like domain bZIP_1 PF00170.21 EEA07830.1 - 2 8.6 14.5 0.069 13.2 3.5 3.3 3 0 0 3 3 3 0 bZIP transcription factor TMPIT PF07851.13 EEA07830.1 - 2.8 7.1 8.3 5.9 6.0 8.3 1.6 1 0 0 1 1 1 0 TMPIT-like protein OmpH PF03938.14 EEA07830.1 - 2.8 8.3 11.7 9.2 6.6 11.7 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) PDCD7 PF16021.5 EEA07830.1 - 2.9 6.9 14.7 4.7 6.2 14.7 1.3 1 0 0 1 1 1 0 Programmed cell death protein 7 DUF4407 PF14362.6 EEA07830.1 - 5.5 6.3 10.9 13 5.0 10.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TSC22 PF01166.18 EEA07830.1 - 5.8 7.3 7.3 1.4 9.3 1.0 3.0 1 1 2 3 3 3 0 TSC-22/dip/bun family Jnk-SapK_ap_N PF09744.9 EEA07830.1 - 8.8 6.5 15.1 13 6.0 13.8 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 EEA07830.1 - 9.4 5.7 10.6 21 4.5 10.6 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit ABC_tran PF00005.27 EEA07832.1 - 5e-05 23.8 0.0 0.00016 22.2 0.0 1.9 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EEA07832.1 - 0.021 14.6 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 EEA07832.1 - 0.087 11.9 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein La PF05383.17 EEA07833.1 - 1.9e-18 66.2 0.5 4e-18 65.2 0.5 1.5 1 0 0 1 1 1 1 La domain RNA_bind PF08675.11 EEA07833.1 - 0.14 12.2 0.2 0.53 10.3 0.1 1.9 2 0 0 2 2 2 0 RNA binding domain Cyclin_N PF00134.23 EEA07834.1 - 2.2e-14 53.3 0.2 1.2e-09 38.0 0.0 3.2 3 0 0 3 3 3 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA07834.1 - 6.1e-14 52.1 0.1 1.7e-13 50.7 0.1 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Myb_DNA-binding PF00249.31 EEA07835.1 - 5.4e-05 23.3 0.1 0.00016 21.8 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain MatP_C PF17414.2 EEA07835.1 - 0.61 10.3 3.1 0.43 10.8 0.7 2.0 2 0 0 2 2 2 0 MatP C-terminal ribbon-helix-helix domain Rad1 PF02144.16 EEA07836.1 - 3.3e-09 36.2 2.0 7.6e-08 31.7 2.0 2.5 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ribonuc_P_40 PF08584.11 EEA07837.1 - 0.0035 16.7 0.1 0.006 15.9 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit Metallophos PF00149.28 EEA07838.1 - 1.7e-36 126.6 0.5 1.7e-36 126.6 0.5 1.6 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EEA07838.1 - 0.00047 20.5 0.6 0.0011 19.4 0.6 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Mito_carr PF00153.27 EEA07839.1 - 8.9e-42 140.9 4.9 1.5e-16 60.1 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2139 PF09910.9 EEA07840.1 - 0.081 12.1 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2139) DUF4448 PF14610.6 EEA07841.1 - 0.079 12.7 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) TFIID-18kDa PF02269.16 EEA07843.1 - 0.00063 19.7 0.1 0.00083 19.3 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit SCAPER_N PF16501.5 EEA07843.1 - 0.011 15.7 0.2 0.021 14.8 0.1 1.5 2 0 0 2 2 2 0 S phase cyclin A-associated protein in the endoplasmic reticulum DUF1283 PF06932.11 EEA07843.1 - 0.053 13.7 0.5 0.19 12.0 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1283) AAA_23 PF13476.6 EEA07844.1 - 3.3e-30 106.1 6.8 3.3e-30 106.1 6.8 5.8 1 1 3 5 5 2 1 AAA domain SMC_N PF02463.19 EEA07844.1 - 4.1e-12 46.0 18.8 4.2e-11 42.7 18.8 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EEA07844.1 - 2.9e-08 33.9 19.2 2.5e-05 24.3 0.1 5.4 6 0 0 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EEA07844.1 - 0.0002 21.0 0.0 0.00045 19.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EEA07844.1 - 0.00036 20.4 30.8 0.00036 20.4 30.8 4.1 1 1 4 5 5 2 2 AAA ATPase domain ABC_tran PF00005.27 EEA07844.1 - 0.0027 18.2 0.0 0.0027 18.2 0.0 5.9 4 2 0 4 4 2 2 ABC transporter AAA_22 PF13401.6 EEA07844.1 - 0.0031 17.8 2.1 0.46 10.8 0.0 3.8 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 EEA07844.1 - 0.0034 17.6 0.0 0.0081 16.4 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EEA07844.1 - 0.0069 16.8 0.0 0.026 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EEA07844.1 - 0.038 14.3 0.6 0.3 11.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain BSP PF04450.12 EEA07844.1 - 0.046 13.5 0.2 0.17 11.7 0.2 2.0 1 0 0 1 1 1 0 Peptidase of plants and bacteria TolA_bind_tri PF16331.5 EEA07844.1 - 0.33 11.1 7.2 14 5.8 0.1 4.5 3 0 0 3 3 3 0 TolA binding protein trimerisation DUF349 PF03993.12 EEA07844.1 - 0.35 11.2 6.9 4.2 7.7 2.9 3.6 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) Sua5_yciO_yrdC PF01300.18 EEA07845.1 - 2.8e-43 147.5 0.0 3.9e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EEA07845.1 - 7.2e-12 46.0 0.0 1.1e-11 45.4 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Actin PF00022.19 EEA07846.1 - 1.7e-34 119.1 0.0 4.1e-24 84.9 0.0 2.3 1 1 1 2 2 2 2 Actin O-FucT PF10250.9 EEA07847.1 - 1.3e-40 140.1 7.4 1.7e-40 139.8 7.4 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase FTHFS PF01268.19 EEA07847.1 - 0.065 11.4 0.0 0.14 10.4 0.0 1.4 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase PUFD PF16553.5 EEA07847.1 - 0.073 13.2 0.1 12 6.1 0.0 2.8 2 0 0 2 2 2 0 BCORL-PCGF1-binding domain Radical_SAM_C PF16199.5 EEA07848.1 - 4.3e-20 71.5 0.3 1.4e-19 69.9 0.1 2.1 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EEA07848.1 - 2.9e-11 44.0 4.0 1.3e-10 41.9 4.0 2.0 1 1 0 1 1 1 1 Radical SAM superfamily PTPA PF03095.15 EEA07850.1 - 3.7e-104 348.4 0.6 4.2e-104 348.2 0.6 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF1829 PF08862.10 EEA07850.1 - 0.073 13.6 0.1 0.15 12.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF1829 Endonuclease_1 PF04231.13 EEA07850.1 - 0.08 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Endonuclease I Actin PF00022.19 EEA07851.1 - 7.5e-69 232.3 0.0 9.2e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EEA07851.1 - 0.0024 16.8 0.0 1.6 7.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Proteasome PF00227.26 EEA07852.1 - 2.3e-34 118.5 0.4 2.9e-34 118.2 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit SRP68 PF16969.5 EEA07853.1 - 4.4e-52 177.9 2.7 1e-46 160.2 0.0 3.3 1 1 1 2 2 2 2 RNA-binding signal recognition particle 68 Filamin PF00630.19 EEA07857.1 - 2e-15 57.5 0.0 5.9e-07 30.2 0.0 3.0 2 0 0 2 2 2 2 Filamin/ABP280 repeat DUF4860 PF16152.5 EEA07857.1 - 0.42 10.5 3.6 0.86 9.5 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4860) KapB PF08810.10 EEA07857.1 - 3.1 8.0 7.5 0.49 10.6 2.7 2.1 2 0 0 2 2 2 0 Kinase associated protein B LMBR1 PF04791.16 EEA07857.1 - 9.1 5.1 10.6 16 4.2 10.6 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Ctr PF04145.15 EEA07858.1 - 2.1e-17 64.1 15.0 2.4e-09 38.0 8.4 2.0 1 1 1 2 2 2 2 Ctr copper transporter family NADHdeh_related PF10125.9 EEA07858.1 - 0.0037 16.6 1.3 0.0042 16.5 1.3 1.1 1 0 0 1 1 1 1 NADH dehydrogenase I, subunit N related protein DUF3963 PF13124.6 EEA07858.1 - 0.059 13.4 2.7 0.059 13.4 2.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) Cytochrom_C_asm PF01578.20 EEA07858.1 - 0.16 11.7 6.5 0.2 11.4 6.5 1.1 1 0 0 1 1 1 0 Cytochrome C assembly protein LapA_dom PF06305.11 EEA07858.1 - 0.21 11.4 6.0 1.2 9.1 0.2 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain PRA1 PF03208.19 EEA07858.1 - 0.47 10.1 9.0 0.62 9.7 9.0 1.1 1 0 0 1 1 1 0 PRA1 family protein Porin_3 PF01459.22 EEA07859.1 - 4.3e-32 111.6 0.2 5.1e-32 111.4 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic porin DUF2219 PF09982.9 EEA07859.1 - 0.024 13.9 0.2 0.11 11.8 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2219) KdgM PF06178.13 EEA07859.1 - 0.11 12.2 0.2 8.4 6.0 0.0 2.7 2 2 1 3 3 3 0 Oligogalacturonate-specific porin protein (KdgM) Pro_isomerase PF00160.21 EEA07860.1 - 4.3e-41 140.8 0.5 1.3e-40 139.2 0.0 1.9 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF5478 PF17572.2 EEA07860.1 - 0.1 12.7 0.5 0.21 11.7 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5478) Hydrolase_4 PF12146.8 EEA07861.1 - 3.6e-11 42.8 0.1 2.8e-07 30.1 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA07861.1 - 1.2e-06 28.4 0.1 0.015 15.0 0.0 2.6 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EEA07861.1 - 0.022 15.4 0.0 0.078 13.6 0.0 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Arf PF00025.21 EEA07862.1 - 1.2e-19 70.5 0.0 5.8e-15 55.2 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family SRPRB PF09439.10 EEA07862.1 - 1.5e-05 24.5 0.0 0.0072 15.8 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit T2SSE PF00437.20 EEA07862.1 - 0.0086 15.2 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 EEA07862.1 - 0.026 14.9 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 EEA07862.1 - 0.036 14.0 0.0 0.19 11.6 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Ras PF00071.22 EEA07862.1 - 0.078 12.6 0.0 0.96 9.0 0.0 2.1 1 1 1 2 2 2 0 Ras family AAA_14 PF13173.6 EEA07862.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA07862.1 - 0.17 11.8 0.1 7.6 6.4 0.1 2.7 3 0 0 3 3 3 0 NACHT domain zinc_ribbon_6 PF14599.6 EEA07863.1 - 2.4e-18 65.9 0.9 2.4e-18 65.9 0.9 4.9 4 2 1 5 5 5 1 Zinc-ribbon zf-CHY PF05495.12 EEA07863.1 - 1.7e-13 50.9 22.6 1.7e-13 50.9 22.6 4.7 2 2 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EEA07863.1 - 2e-07 31.2 3.1 2e-07 31.2 3.1 6.2 3 2 3 6 6 6 1 Ring finger domain zf-RING_5 PF14634.6 EEA07863.1 - 5.1e-07 29.5 2.2 5.1e-07 29.5 2.2 6.1 4 3 1 5 5 5 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA07863.1 - 1.2e-05 25.2 1.3 1.2e-05 25.2 1.3 5.6 7 1 1 8 8 8 1 RING-type zinc-finger Rtf2 PF04641.12 EEA07863.1 - 0.00079 18.9 1.0 0.00079 18.9 1.0 1.6 1 1 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EEA07863.1 - 0.0021 18.2 3.2 0.0021 18.2 3.2 5.6 4 1 4 8 8 8 1 zinc finger of C3HC4-type, RING zinc_ribbon_2 PF13240.6 EEA07863.1 - 0.3 10.9 0.1 0.3 10.9 0.1 7.3 9 0 0 9 9 9 0 zinc-ribbon domain TFIID_NTD2 PF04494.15 EEA07864.1 - 5.1e-22 78.5 4.8 1.1e-21 77.4 4.8 1.6 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 EEA07864.1 - 3.1e-17 62.6 24.2 3.4e-06 27.7 1.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA07864.1 - 0.0051 17.1 0.0 12 6.3 0.0 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Na_Ca_ex PF01699.24 EEA07866.1 - 2.3e-37 128.3 41.9 7.5e-21 74.7 18.3 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Pkinase PF00069.25 EEA07867.1 - 5.8e-61 206.2 0.0 7.6e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07867.1 - 5.8e-35 120.8 0.0 3.5e-33 115.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA07867.1 - 1.4e-08 34.5 0.1 4.9e-07 29.4 0.0 2.4 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EEA07867.1 - 0.0012 17.7 0.0 0.0019 17.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase zf-ANAPC11 PF12861.7 EEA07868.1 - 1.4e-26 92.4 9.7 1.8e-26 92.0 9.7 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EEA07868.1 - 2.2e-21 75.9 12.6 2.9e-21 75.5 12.6 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EEA07868.1 - 3.3e-07 30.5 17.6 3e-06 27.5 17.1 2.3 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EEA07868.1 - 1.9e-05 24.6 8.3 2e-05 24.5 6.5 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA07868.1 - 9.6e-05 22.2 14.7 0.00048 19.9 14.3 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA07868.1 - 0.0005 20.0 13.2 0.0027 17.6 12.4 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EEA07868.1 - 0.00058 19.7 13.9 0.025 14.5 2.8 2.2 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA07868.1 - 0.00076 19.6 2.6 0.00076 19.6 2.6 2.7 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EEA07868.1 - 0.00092 19.0 13.1 0.0014 18.3 2.7 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 EEA07868.1 - 0.0034 17.2 6.4 0.0034 17.2 6.4 2.8 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EEA07868.1 - 0.012 15.4 14.9 0.28 10.9 14.9 2.5 1 1 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 EEA07868.1 - 0.021 14.7 14.4 8.9 6.3 14.6 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.14 EEA07868.1 - 0.044 13.6 2.4 0.35 10.7 0.0 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-HIT PF04438.16 EEA07868.1 - 0.05 13.5 2.0 0.05 13.5 2.0 2.2 2 0 0 2 2 2 0 HIT zinc finger Pellino PF04710.14 EEA07868.1 - 0.18 10.4 4.8 0.041 12.6 1.0 1.5 1 1 1 2 2 2 0 Pellino FANCL_C PF11793.8 EEA07868.1 - 0.24 11.6 14.6 2.2 8.5 14.1 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain TerY_C PF15616.6 EEA07868.1 - 0.98 9.5 8.2 3.4 7.8 8.2 1.8 1 1 0 1 1 1 0 TerY-C metal binding domain zf-C2H2_6 PF13912.6 EEA07868.1 - 1.1 9.3 0.1 1.1 9.3 0.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-HC5HC2H_2 PF13832.6 EEA07868.1 - 1.2 9.3 9.7 4.4 7.5 9.8 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain Zn_ribbon_17 PF17120.5 EEA07868.1 - 2.9 7.6 15.0 25 4.6 14.7 2.2 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF2256 PF10013.9 EEA07868.1 - 8.8 6.5 10.1 5.9 7.1 0.3 3.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) HA2 PF04408.23 EEA07869.1 - 5.5e-20 71.7 0.0 1.4e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EEA07869.1 - 1.7e-19 69.9 0.0 3.9e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EEA07869.1 - 2e-13 50.6 0.1 7.9e-13 48.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA07869.1 - 2.5e-06 27.4 0.0 1e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EEA07869.1 - 0.00012 22.4 0.0 0.00048 20.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EEA07869.1 - 0.0022 18.3 0.0 0.0054 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EEA07869.1 - 0.012 15.4 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EEA07869.1 - 0.015 14.4 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 EEA07869.1 - 0.025 14.1 0.6 0.87 9.1 0.0 2.9 3 0 0 3 3 3 0 P-loop containing dynein motor region ABC_tran PF00005.27 EEA07869.1 - 0.091 13.3 0.1 0.49 10.9 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Acetyltransf_1 PF00583.25 EEA07870.1 - 1.5e-18 67.1 0.0 1.9e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EEA07870.1 - 2e-12 47.4 0.0 2.7e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EEA07870.1 - 1.5e-11 44.3 0.0 1.9e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EEA07870.1 - 6.2e-07 29.3 0.0 9.2e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EEA07870.1 - 5.2e-06 26.6 0.1 9.1e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EEA07870.1 - 0.00043 20.5 0.1 0.00053 20.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EEA07870.1 - 0.052 13.5 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase MSP1b PF03429.13 EEA07871.1 - 0.061 11.4 0.2 0.072 11.2 0.2 1.1 1 0 0 1 1 1 0 Major surface protein 1B Ank_2 PF12796.7 EEA07872.1 - 2.4e-25 88.9 4.9 3.7e-07 30.6 0.1 4.4 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA07872.1 - 9.4e-23 80.3 5.6 9e-07 29.3 0.0 5.4 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA07872.1 - 5.5e-19 66.3 7.0 0.00056 20.2 0.1 7.2 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EEA07872.1 - 2e-15 56.5 2.7 0.0021 18.4 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EEA07872.1 - 8.8e-13 48.2 6.9 0.0072 16.6 0.2 6.0 3 2 3 6 6 6 5 Ankyrin repeats (many copies) TPR_2 PF07719.17 EEA07872.1 - 8.5e-07 28.6 1.6 0.41 10.9 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA07872.1 - 4.8e-06 26.1 4.5 0.032 14.0 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA07872.1 - 0.00056 19.9 3.3 8.1 6.9 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA07872.1 - 0.032 14.6 0.0 3.1 8.4 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat WBS_methylT PF12589.8 EEA07873.1 - 6.7e-19 68.4 3.8 9.9e-19 67.9 3.8 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 EEA07873.1 - 1.8e-08 35.0 0.0 3.4e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA07873.1 - 4.5e-08 33.6 0.0 8.6e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA07873.1 - 7.6e-06 25.9 0.0 9.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA07873.1 - 0.00077 20.2 0.0 0.002 18.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA07873.1 - 0.0048 16.7 0.0 0.0092 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 EEA07873.1 - 0.012 15.9 0.0 0.076 13.3 0.0 2.2 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 EEA07873.1 - 0.034 14.1 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EEA07873.1 - 0.039 13.3 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EEA07873.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) LSM PF01423.22 EEA07874.1 - 1.3e-20 72.8 0.0 1.6e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain Peptidase_M24 PF00557.24 EEA07875.1 - 7.7e-51 172.7 0.0 1.1e-50 172.2 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EEA07875.1 - 8.9e-15 54.7 5.1 2e-14 53.6 5.1 1.6 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EEA07875.1 - 2.2e-06 27.6 3.7 6.2e-06 26.2 3.7 1.8 1 0 0 1 1 1 1 MYND finger RNA_pol_A_bac PF01000.26 EEA07876.1 - 4.6e-25 88.2 0.0 1.6e-24 86.4 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EEA07876.1 - 4.8e-24 83.6 0.0 6.7e-24 83.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 EEA07876.1 - 0.0022 18.1 0.2 0.0022 18.1 0.2 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EEA07876.1 - 0.007 16.9 0.8 0.007 16.9 0.8 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4 PF00037.27 EEA07876.1 - 0.025 14.4 2.3 0.025 14.4 2.3 2.7 3 0 0 3 3 3 0 4Fe-4S binding domain RRM_1 PF00076.22 EEA07878.1 - 1e-48 163.0 0.0 5.4e-21 74.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA07878.1 - 0.0001 22.4 0.0 0.18 11.9 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EEA07878.1 - 0.0036 17.3 0.0 0.015 15.3 0.0 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EEA07878.1 - 0.11 12.1 0.0 2.6 7.7 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zw10 PF06248.13 EEA07879.1 - 6.2e-25 87.8 14.3 2.2e-24 86.0 11.5 2.6 2 1 0 2 2 2 1 Centromere/kinetochore Zw10 DUF438 PF04282.13 EEA07879.1 - 0.074 13.0 0.1 0.53 10.3 0.1 2.5 1 0 0 1 1 1 0 Family of unknown function (DUF438) Lyase_8_N PF08124.11 EEA07879.1 - 0.092 11.6 0.0 0.23 10.4 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain AAA PF00004.29 EEA07880.1 - 2.5e-14 53.8 0.3 1e-13 51.9 0.0 2.2 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Adeno_IVa2 PF02456.15 EEA07880.1 - 4.9e-05 22.3 0.8 0.022 13.5 0.0 2.2 2 0 0 2 2 2 2 Adenovirus IVa2 protein Rad17 PF03215.15 EEA07880.1 - 0.00016 21.7 0.6 0.0068 16.4 0.0 2.8 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 EEA07880.1 - 0.00026 21.4 0.1 0.0024 18.3 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EEA07880.1 - 0.00072 19.9 0.0 0.0024 18.2 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 EEA07880.1 - 0.00078 19.4 0.2 0.015 15.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA07880.1 - 0.0032 17.8 0.1 0.026 14.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EEA07880.1 - 0.004 17.1 0.5 0.045 13.7 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EEA07880.1 - 0.0046 16.4 0.0 0.012 15.0 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EEA07880.1 - 0.0049 16.6 0.2 1.8 8.3 0.0 2.4 1 1 1 2 2 2 1 IstB-like ATP binding protein ABC_tran PF00005.27 EEA07880.1 - 0.0053 17.3 0.1 0.014 15.9 0.0 1.9 2 1 0 2 2 1 1 ABC transporter DUF815 PF05673.13 EEA07880.1 - 0.021 14.0 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MCM PF00493.23 EEA07880.1 - 0.021 13.9 0.0 0.052 12.6 0.0 1.7 1 0 0 1 1 1 0 MCM P-loop domain MMR_HSR1 PF01926.23 EEA07880.1 - 0.035 14.2 0.1 0.13 12.4 0.1 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EEA07880.1 - 0.038 14.5 0.0 0.092 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EEA07880.1 - 0.046 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EEA07880.1 - 0.051 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 EEA07880.1 - 0.072 13.3 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EEA07880.1 - 0.12 12.0 0.1 0.32 10.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA07880.1 - 0.14 12.1 2.6 0.61 10.0 0.1 3.2 3 1 0 3 3 3 0 NACHT domain Zeta_toxin PF06414.12 EEA07880.1 - 0.18 11.1 0.0 0.62 9.3 0.0 1.9 3 0 0 3 3 2 0 Zeta toxin AAA_29 PF13555.6 EEA07880.1 - 0.18 11.6 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EEA07880.1 - 0.58 10.6 5.9 0.77 10.2 0.1 3.2 2 1 1 3 3 2 0 AAA domain Cullin_Nedd8 PF10557.9 EEA07880.1 - 3 7.9 5.9 5.2 7.2 0.2 4.0 5 0 0 5 5 5 0 Cullin protein neddylation domain YchF-GTPase_C PF06071.13 EEA07881.1 - 3.5e-40 136.1 0.2 8e-40 134.9 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EEA07881.1 - 5.5e-21 74.8 0.0 2.5e-20 72.6 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA07881.1 - 6.2e-07 29.1 0.0 2.5e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA PF00004.29 EEA07881.1 - 0.043 14.2 0.0 0.087 13.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TGS PF02824.21 EEA07881.1 - 0.047 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 TGS domain RNA_pol_Rpb2_6 PF00562.28 EEA07882.1 - 4e-112 375.1 0.0 6.4e-112 374.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EEA07882.1 - 6.8e-34 117.2 0.0 1.3e-33 116.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EEA07882.1 - 8e-26 90.0 0.0 1.9e-25 88.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EEA07882.1 - 1.2e-18 67.3 0.0 2.9e-18 66.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 EEA07882.1 - 1.4e-08 34.6 0.0 3.3e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain zf_C2H2_6 PF18450.1 EEA07882.1 - 0.033 13.9 0.3 0.083 12.6 0.3 1.7 1 0 0 1 1 1 0 Zinc Finger domain PGG PF13962.6 EEA07883.1 - 2.5 7.9 6.6 1 9.2 3.1 2.1 1 1 1 2 2 2 0 Domain of unknown function DUF2012 PF09430.10 EEA07884.1 - 3.4e-10 40.1 0.2 4.5e-10 39.7 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 EEA07884.1 - 0.0019 18.4 0.0 0.0029 17.8 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EEA07884.1 - 0.0068 16.4 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Y_Y_Y PF07495.13 EEA07884.1 - 0.0071 16.3 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 Y_Y_Y domain SpaA PF17802.1 EEA07884.1 - 0.16 12.3 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Prealbumin-like fold domain Ufm1 PF03671.14 EEA07885.1 - 2.4e-39 133.3 0.3 2.8e-39 133.1 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Rad60-SLD PF11976.8 EEA07885.1 - 0.19 11.6 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Med7 PF05983.11 EEA07886.1 - 7.4e-23 81.6 13.3 6.9e-21 75.2 13.3 2.0 1 1 0 1 1 1 1 MED7 protein DUF641 PF04859.12 EEA07886.1 - 0.017 15.4 3.2 0.026 14.8 3.3 1.3 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Laminin_II PF06009.12 EEA07886.1 - 0.062 13.3 1.6 0.082 12.9 1.6 1.3 1 0 0 1 1 1 0 Laminin Domain II HAUS6_N PF14661.6 EEA07886.1 - 0.13 11.9 1.9 0.16 11.5 1.9 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus CART PF06373.11 EEA07886.1 - 0.32 11.2 2.2 1.1 9.5 0.2 2.5 2 1 0 3 3 3 0 Cocaine and amphetamine regulated transcript protein (CART) AAA_23 PF13476.6 EEA07886.1 - 0.78 10.2 6.0 0.97 9.9 6.0 1.1 1 0 0 1 1 1 0 AAA domain TRM13 PF05206.14 EEA07887.1 - 6.6e-32 111.1 15.3 3.6e-14 52.9 2.8 4.0 2 2 2 4 4 4 3 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 EEA07887.1 - 1.2e-06 28.1 1.9 1.2e-06 28.1 1.9 2.5 3 0 0 3 3 3 1 CCCH zinc finger in TRM13 protein SNARE PF05739.19 EEA07889.1 - 2.7e-13 49.7 0.1 1.1e-12 47.7 0.1 2.1 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EEA07889.1 - 0.00033 20.4 11.6 0.042 13.5 3.3 2.6 2 1 1 3 3 3 2 Syntaxin Prominin PF05478.11 EEA07889.1 - 0.00047 18.3 10.3 0.0081 14.2 1.1 2.0 1 1 1 2 2 2 2 Prominin Lipoprotein_7 PF01540.16 EEA07889.1 - 0.00065 19.1 4.6 0.017 14.5 0.6 2.9 2 1 0 2 2 2 1 Adhesin lipoprotein KxDL PF10241.9 EEA07889.1 - 0.0093 16.2 0.8 0.0093 16.2 0.8 3.2 3 1 0 3 3 3 1 Uncharacterized conserved protein Ribonuc_2-5A PF06479.12 EEA07889.1 - 0.025 14.8 6.1 0.038 14.2 0.6 3.1 3 1 0 3 3 3 0 Ribonuclease 2-5A Syntaxin-6_N PF09177.11 EEA07889.1 - 0.025 15.1 4.6 0.87 10.2 1.4 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Terminase_6C PF17289.2 EEA07889.1 - 0.082 13.0 0.7 5.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Terminase RNaseH-like domain DUF1664 PF07889.12 EEA07889.1 - 0.084 12.9 9.0 0.52 10.3 1.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) SH3BP5 PF05276.14 EEA07889.1 - 0.1 12.4 5.9 0.11 12.3 0.2 2.5 2 1 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) GLTSCR1 PF15249.6 EEA07889.1 - 0.35 11.3 2.5 9.3 6.8 0.0 3.0 2 2 1 3 3 3 0 Conserved region of unknown function on GLTSCR protein Snapin_Pallidin PF14712.6 EEA07889.1 - 0.38 11.2 12.8 0.21 12.0 2.0 3.2 3 1 1 4 4 4 0 Snapin/Pallidin Vac_Fusion PF02346.16 EEA07889.1 - 0.7 9.6 4.5 2.1 8.0 0.0 3.2 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF745 PF05335.13 EEA07889.1 - 0.72 9.5 6.3 9.6 5.9 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Tup_N PF08581.10 EEA07889.1 - 0.78 10.1 12.0 0.59 10.5 3.3 3.2 2 1 1 3 3 3 0 Tup N-terminal AI-2E_transport PF01594.16 EEA07889.1 - 0.9 8.6 6.8 0.29 10.3 0.5 2.5 2 1 2 4 4 4 0 AI-2E family transporter Rx_N PF18052.1 EEA07889.1 - 1.2 9.5 4.0 11 6.4 1.3 3.1 2 1 0 2 2 2 0 Rx N-terminal domain MCPsignal PF00015.21 EEA07889.1 - 1.3 8.8 7.0 2.7 7.8 1.2 2.7 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CLZ PF16526.5 EEA07889.1 - 1.5 9.3 9.0 6 7.3 0.1 3.3 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Apolipoprotein PF01442.18 EEA07889.1 - 2.2 8.1 8.1 6.4 6.6 2.6 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain COG5 PF10392.9 EEA07889.1 - 2.4 8.4 10.0 1.6 8.9 0.1 3.3 3 2 0 3 3 3 0 Golgi transport complex subunit 5 DUF5082 PF16888.5 EEA07889.1 - 2.5 8.4 11.7 1.7 8.9 0.9 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) FliJ PF02050.16 EEA07889.1 - 3.4 7.9 14.3 5.7 7.2 3.9 2.9 2 1 1 3 3 3 0 Flagellar FliJ protein DASH_Dad1 PF08649.10 EEA07889.1 - 7.7 6.8 11.4 16 5.8 0.6 3.9 4 1 0 4 4 3 0 DASH complex subunit Dad1 DUF3456 PF11938.8 EEA07889.1 - 9.6 6.7 7.0 1.4e+02 2.9 6.7 2.4 1 1 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP CPSF_A PF03178.15 EEA07890.1 - 1.3e-32 113.4 1.8 5.9e-26 91.5 0.1 2.9 2 1 1 3 3 3 2 CPSF A subunit region MMS1_N PF10433.9 EEA07890.1 - 4.1e-25 88.4 1.1 2.8e-24 85.6 0.8 2.4 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Pkinase PF00069.25 EEA07891.1 - 2.7e-46 158.1 0.0 5.2e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07891.1 - 1.5e-31 109.6 0.0 2.8e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA07891.1 - 3e-08 33.3 0.0 5.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EEA07891.1 - 0.044 13.7 0.0 0.069 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ubie_methyltran PF01209.18 EEA07892.1 - 6.4e-73 244.9 1.5 1.5e-71 240.4 1.5 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EEA07892.1 - 5.8e-14 52.6 0.0 1.4e-12 48.2 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA07892.1 - 8.1e-14 52.0 0.0 1.2e-11 45.1 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA07892.1 - 4.5e-12 46.0 0.0 8.2e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EEA07892.1 - 1.4e-07 32.1 0.1 4.7e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA07892.1 - 1.5e-05 24.9 0.0 2.3e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EEA07892.1 - 0.0067 16.3 0.1 0.022 14.6 0.0 1.9 3 0 0 3 3 3 1 Hypothetical methyltransferase YccV-like PF08755.11 EEA07893.1 - 8.8e-22 77.5 0.2 2.6e-21 76.0 0.2 1.9 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like PRKCSH PF07915.13 EEA07893.1 - 0.074 14.1 6.6 0.086 13.9 0.0 4.1 4 0 0 4 4 4 0 Glucosidase II beta subunit-like protein Utp21 PF04192.12 EEA07894.1 - 1.9e-41 142.1 0.8 2.9e-41 141.5 0.8 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EEA07894.1 - 5.2e-13 49.1 0.0 3.9e-07 30.3 0.0 4.2 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA07894.1 - 1.1e-09 38.8 11.0 0.0021 18.8 0.0 6.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ECH_2 PF16113.5 EEA07894.1 - 0.18 11.3 0.0 0.44 10.0 0.0 1.6 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase Reo_P9 PF06043.11 EEA07895.1 - 0.097 12.1 2.2 0.31 10.4 0.7 2.1 2 0 0 2 2 2 0 Reovirus P9-like family LSM PF01423.22 EEA07896.1 - 2e-22 78.6 1.1 2.9e-22 78.1 1.1 1.3 1 0 0 1 1 1 1 LSM domain V-SNARE_C PF12352.8 EEA07897.1 - 1.2e-10 41.5 1.2 1.2e-10 41.5 1.2 2.6 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EEA07897.1 - 6.7e-06 25.9 2.6 1.1e-05 25.3 0.2 2.3 2 1 1 3 3 3 1 Sec20 DUF4972 PF16342.5 EEA07897.1 - 0.007 16.1 1.5 0.15 11.8 1.5 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4972) CCDC84 PF14968.6 EEA07897.1 - 0.12 12.0 0.6 0.16 11.6 0.6 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 HATPase_c PF02518.26 EEA07898.1 - 2e-10 41.2 0.0 4e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EEA07898.1 - 1.3e-06 28.2 0.1 4.2e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase XAP5 PF04921.14 EEA07899.1 - 2.3e-56 191.4 4.7 2.6e-56 191.2 4.7 1.1 1 0 0 1 1 1 1 XAP5, circadian clock regulator Pkinase PF00069.25 EEA07900.1 - 1.9e-35 122.5 0.0 8.6e-19 67.9 0.0 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07900.1 - 3.8e-10 39.5 0.0 0.00035 19.9 0.0 3.4 3 0 0 3 3 3 3 Protein tyrosine kinase T2SSL PF05134.13 EEA07900.1 - 0.055 12.8 0.1 0.099 12.0 0.1 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein L DnaJ PF00226.31 EEA07901.1 - 1.1e-12 47.9 3.2 3.8e-12 46.2 0.3 2.3 2 0 0 2 2 2 1 DnaJ domain 14-3-3 PF00244.20 EEA07902.1 - 4.6e-40 137.5 0.3 5.3e-40 137.3 0.3 1.0 1 0 0 1 1 1 1 14-3-3 protein mCpol PF18182.1 EEA07902.1 - 0.15 12.4 1.2 0.67 10.3 0.1 2.3 2 0 0 2 2 2 0 minimal CRISPR polymerase domain EST1 PF10374.9 EEA07902.1 - 0.2 12.3 0.7 0.85 10.3 0.7 2.1 1 1 0 1 1 1 0 Telomerase activating protein Est1 CGI-121 PF08617.10 EEA07903.1 - 1.3e-24 87.2 6.6 1.6e-24 86.8 6.6 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 LZ3wCH PF18517.1 EEA07903.1 - 0.039 14.0 0.2 0.14 12.2 0.2 1.9 1 0 0 1 1 1 0 Leucine zipper with capping helix domain Ribosomal_L27e PF01777.18 EEA07904.1 - 4.5e-21 75.0 1.9 6.4e-21 74.5 1.9 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EEA07904.1 - 0.00011 22.0 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 KOW motif DnaB_bind PF10410.9 EEA07904.1 - 0.025 14.7 0.1 0.046 13.9 0.1 1.4 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase ATHILA PF03078.15 EEA07904.1 - 0.061 12.1 0.0 0.07 11.9 0.0 1.1 1 0 0 1 1 1 0 ATHILA ORF-1 family ER_lumen_recept PF00810.18 EEA07905.1 - 3.1e-36 125.4 3.8 3.1e-36 125.4 3.8 2.0 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EEA07905.1 - 0.055 13.2 0.2 0.055 13.2 0.2 3.8 2 1 1 4 4 4 0 PQ loop repeat Glycolytic PF00274.19 EEA07906.1 - 8.8e-163 541.0 0.1 9.9e-163 540.8 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Zn_ribbon_17 PF17120.5 EEA07907.1 - 4.5e-06 26.2 12.6 4.5e-06 26.2 12.6 2.5 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type ANAPC4_WD40 PF12894.7 EEA07907.1 - 0.00051 20.3 0.1 1.3 9.4 0.0 3.5 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain SAM_LFY PF01698.16 EEA07908.1 - 0.036 14.0 0.1 0.42 10.6 0.0 2.4 2 1 0 2 2 2 0 Floricaula / Leafy protein SAM domain DUF1633 PF07794.11 EEA07908.1 - 0.16 10.1 3.7 0.096 10.9 1.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1633) ApoO PF09769.9 EEA07908.1 - 0.19 11.7 3.4 15 5.6 0.1 3.2 1 1 2 3 3 3 0 Apolipoprotein O Med2 PF11214.8 EEA07908.1 - 0.5 10.6 17.4 0.32 11.2 1.2 3.3 2 2 1 3 3 3 0 Mediator complex subunit 2 SKA2 PF16740.5 EEA07908.1 - 0.86 9.4 15.4 0.17 11.7 4.6 3.2 1 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF948 PF06103.11 EEA07908.1 - 1.1 9.6 7.0 2.8 8.3 2.1 2.9 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) SF-assemblin PF06705.11 EEA07908.1 - 2.4 7.4 33.7 0.34 10.2 7.3 3.2 1 1 3 4 4 4 0 SF-assemblin/beta giardin AI-2E_transport PF01594.16 EEA07908.1 - 6.8 5.7 5.6 3.4 6.7 0.9 2.1 1 1 1 2 2 2 0 AI-2E family transporter TIM PF00121.18 EEA07909.1 - 7.3e-90 300.6 0.1 8.2e-90 300.4 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Cation_efflux PF01545.21 EEA07910.1 - 1.9e-44 151.8 14.7 2.4e-44 151.5 14.7 1.1 1 0 0 1 1 1 1 Cation efflux family Cation_ATPase_C PF00689.21 EEA07910.1 - 1.9 8.1 16.2 1.2 8.9 11.6 2.4 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus DUF3671 PF12420.8 EEA07910.1 - 7.7 6.6 11.7 0.51 10.4 4.2 2.8 2 1 1 3 3 3 0 Protein of unknown function Polysacc_deac_1 PF01522.21 EEA07911.1 - 8.1e-11 41.9 0.0 2.3e-09 37.2 0.0 2.2 2 0 0 2 2 2 2 Polysaccharide deacetylase RRM_1 PF00076.22 EEA07913.1 - 5.2e-06 26.2 0.0 0.0054 16.5 0.0 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GCP_C_terminal PF04130.13 EEA07915.1 - 6.2e-07 29.2 10.9 6.2e-07 29.2 10.9 2.0 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal Condensation PF00668.20 EEA07916.1 - 1.3e-06 27.3 0.2 1.1e-05 24.3 0.0 2.4 3 0 0 3 3 3 1 Condensation domain DUF1870 PF08965.10 EEA07916.1 - 0.19 11.8 0.7 27 4.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1870) Sas10 PF09368.10 EEA07917.1 - 8.7e-23 80.6 7.2 8.7e-23 80.6 7.2 3.7 3 1 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EEA07917.1 - 3e-16 59.8 1.5 3e-16 59.8 1.5 3.7 4 0 0 4 4 4 1 Sas10/Utp3/C1D family Svf1_C PF17187.4 EEA07917.1 - 0.0057 16.5 0.8 0.012 15.4 0.1 1.9 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Serine_rich PF08824.10 EEA07917.1 - 0.66 10.0 7.0 0.16 12.0 0.7 2.9 3 0 0 3 3 3 0 Serine rich protein interaction domain MutS_II PF05188.17 EEA07917.1 - 1.1 9.5 5.4 2.4 8.4 0.1 3.4 2 1 1 3 3 3 0 MutS domain II ADK PF00406.22 EEA07918.1 - 9e-43 146.0 0.0 1.1e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EEA07918.1 - 2.5e-31 108.9 0.0 3.4e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EEA07918.1 - 1.1e-11 45.4 0.0 1.7e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EEA07918.1 - 4.6e-07 30.1 0.0 6.8e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EEA07918.1 - 0.00066 19.4 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase AAA_7 PF12775.7 EEA07918.1 - 0.012 15.2 0.0 5.2 6.5 0.0 2.5 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_22 PF13401.6 EEA07918.1 - 0.018 15.3 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EEA07918.1 - 0.026 14.9 0.0 0.055 13.9 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 EEA07918.1 - 0.046 13.6 0.0 0.1 12.4 0.0 1.5 2 0 0 2 2 2 0 Deoxynucleoside kinase ATP_bind_1 PF03029.17 EEA07918.1 - 0.14 11.9 0.1 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Cyclin_N PF00134.23 EEA07919.1 - 8.7e-08 32.0 0.7 1.9e-07 30.9 0.5 1.7 1 1 0 1 1 1 1 Cyclin, N-terminal domain Suf PF05843.14 EEA07920.1 - 2.7e-10 40.7 3.2 1.1e-06 28.9 0.4 3.7 4 0 0 4 4 4 3 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EEA07920.1 - 0.086 13.3 1.7 2 9.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat NAD_binding_6 PF08030.12 EEA07920.1 - 7.6 6.6 8.6 0.83 9.8 0.3 3.1 3 0 0 3 3 3 0 Ferric reductase NAD binding domain PH PF00169.29 EEA07921.1 - 2.7e-05 24.6 16.8 0.019 15.4 0.2 5.4 6 0 0 6 6 6 3 PH domain FERM_C PF09380.10 EEA07921.1 - 0.00095 19.5 1.3 0.0075 16.6 0.2 2.9 2 0 0 2 2 2 1 FERM C-terminal PH-like domain PH_17 PF18012.1 EEA07921.1 - 0.097 12.4 0.1 15 5.4 0.0 2.8 2 0 0 2 2 2 0 PH domain Prp19 PF08606.11 EEA07921.1 - 0.15 12.0 1.4 0.52 10.3 0.7 2.3 2 0 0 2 2 2 0 Prp19/Pso4-like Vma12 PF11712.8 EEA07924.1 - 7.8e-07 29.2 0.0 1.2e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2207 PF09972.9 EEA07924.1 - 0.026 13.3 1.0 0.032 13.0 1.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) GBP PF02263.19 EEA07925.1 - 1.4e-08 34.4 1.1 0.0002 20.7 0.1 2.7 2 0 0 2 2 2 2 Guanylate-binding protein, N-terminal domain EF-hand_6 PF13405.6 EEA07926.1 - 1.6e-07 30.7 3.5 0.016 15.1 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EEA07926.1 - 1.7e-06 27.2 3.2 0.028 14.0 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EEA07926.1 - 5.5e-06 26.7 1.4 0.017 15.5 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EEA07926.1 - 6.5e-05 22.7 4.0 0.027 14.3 0.1 3.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 EEA07926.1 - 0.00047 19.5 0.6 1.1 8.9 0.0 3.2 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EEA07926.1 - 0.012 16.0 0.1 0.6 10.4 0.0 2.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.25 EEA07927.1 - 1e-28 100.5 0.0 2.5e-28 99.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA07927.1 - 4.1e-08 32.8 0.0 7.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Rav1p_C PF12234.8 EEA07928.1 - 1.7e-14 53.2 5.7 2e-11 43.1 0.0 3.3 3 0 0 3 3 3 3 RAVE protein 1 C terminal EI24 PF07264.11 EEA07929.1 - 0.015 15.6 0.2 0.019 15.2 0.2 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF2116 PF09889.9 EEA07929.1 - 0.09 12.8 4.9 1.4 8.9 1.0 2.6 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) ANAPC4_WD40 PF12894.7 EEA07931.1 - 0.00042 20.5 0.0 0.083 13.2 0.0 2.7 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain NUC153 PF08159.12 EEA07931.1 - 0.0053 16.6 0.8 0.016 15.0 0.8 1.9 1 0 0 1 1 1 1 NUC153 domain Adaptin_binding PF10199.9 EEA07932.1 - 1.5e-11 44.9 0.8 1.7e-09 38.3 0.8 2.3 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Abhydrolase_2 PF02230.16 EEA07933.1 - 1.3e-46 159.2 0.3 3.9e-45 154.3 0.3 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EEA07933.1 - 3.9e-05 23.4 0.0 5.9e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DUF676 PF05057.14 EEA07933.1 - 0.002 17.7 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 EEA07933.1 - 0.021 14.7 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 EEA07933.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.25 EEA07933.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) MAT1 PF06391.13 EEA07934.1 - 6.9e-09 35.8 12.7 7.2e-09 35.8 11.7 1.6 1 1 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-RING_2 PF13639.6 EEA07934.1 - 1.5e-07 31.7 4.5 6.3e-07 29.6 4.5 2.0 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EEA07934.1 - 8.5e-06 25.7 4.2 9.7e-06 25.5 1.5 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA07934.1 - 7.8e-05 22.6 6.3 0.00035 20.5 6.5 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA07934.1 - 0.00023 21.0 7.0 0.00035 20.3 1.8 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA07934.1 - 0.00023 20.9 7.6 0.00096 19.0 7.6 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA07934.1 - 0.00041 20.1 5.9 0.04 13.8 0.3 3.3 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 HEPN_RnaseLS PF18869.1 EEA07934.1 - 0.00051 20.2 0.1 0.0012 19.0 0.1 1.6 1 0 0 1 1 1 1 RnaseLS-like HEPN zf-C3HC4 PF00097.25 EEA07934.1 - 0.0017 18.2 10.9 0.0087 15.9 11.0 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA07934.1 - 0.0024 18.0 2.8 0.0024 18.0 2.8 3.0 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-NADH-PPase PF09297.11 EEA07934.1 - 0.0079 15.8 0.9 0.79 9.4 0.1 3.0 3 0 0 3 3 3 1 NADH pyrophosphatase zinc ribbon domain zf-RING_4 PF14570.6 EEA07934.1 - 0.02 14.7 4.5 0.085 12.7 4.5 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FYVE PF01363.21 EEA07934.1 - 0.026 14.7 3.0 0.053 13.7 3.0 1.5 1 0 0 1 1 1 0 FYVE zinc finger zf-C3HC4_5 PF17121.5 EEA07934.1 - 0.033 14.1 8.6 0.078 12.9 4.5 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF393 PF04134.12 EEA07934.1 - 0.12 13.7 0.0 0.26 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF393 Porphobil_deam PF01379.20 EEA07934.1 - 0.13 11.8 0.1 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain DPRP PF04244.13 EEA07934.1 - 0.14 12.0 3.5 0.28 11.0 1.1 2.0 1 1 1 2 2 2 0 Deoxyribodipyrimidine photo-lyase-related protein DUF5318 PF17249.2 EEA07934.1 - 0.16 11.7 0.4 1.1 9.0 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5318) TetR_C_24 PF17932.1 EEA07934.1 - 0.2 11.9 0.1 0.4 11.0 0.1 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Cyclin_N PF00134.23 EEA07935.1 - 9.2e-06 25.4 2.1 1.4e-05 24.8 0.2 2.3 2 1 1 3 3 3 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EEA07935.1 - 0.0056 17.0 2.4 0.058 13.8 0.3 3.3 2 1 1 3 3 3 1 Cyclin C-terminal domain zf-C3HC4_2 PF13923.6 EEA07936.1 - 5e-11 42.3 8.3 1.2e-10 41.0 8.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA07936.1 - 1.4e-09 37.6 10.2 3.3e-09 36.5 10.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA07936.1 - 5.6e-05 23.4 8.6 6.4e-05 23.2 7.5 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EEA07936.1 - 6.3e-05 22.8 4.8 6.3e-05 22.8 4.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA07936.1 - 0.00023 21.2 9.4 0.00051 20.1 9.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EEA07936.1 - 0.00035 20.3 5.1 0.00052 19.8 3.9 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EEA07936.1 - 0.0015 18.5 8.6 0.0015 18.5 8.6 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA07936.1 - 0.0032 17.4 9.8 0.009 16.0 9.8 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 EEA07936.1 - 0.0043 16.9 4.1 0.009 15.9 4.1 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein OTT_1508_deam PF14441.6 EEA07936.1 - 0.038 14.0 1.3 0.67 10.0 1.3 2.6 1 1 0 1 1 1 0 OTT_1508-like deaminase zf-ANAPC11 PF12861.7 EEA07936.1 - 0.082 13.0 2.0 0.2 11.7 2.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_5 PF17121.5 EEA07936.1 - 0.38 10.7 15.2 1.3 9.0 7.6 3.8 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA07936.1 - 1.6 8.7 10.0 48 3.9 10.7 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EEA07936.1 - 3.3 7.6 9.9 29 4.6 10.1 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Transgly PF00912.22 EEA07937.1 - 0.093 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Transglycosylase MTBP_C PF14920.6 EEA07937.1 - 0.15 11.8 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 MDM2-binding Hydrolase_3 PF08282.12 EEA07938.1 - 2.8e-43 148.5 0.2 1.2e-42 146.5 0.2 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EEA07938.1 - 7e-17 61.8 0.0 1.3e-13 51.0 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EEA07938.1 - 1.2e-05 25.7 0.0 0.0002 21.7 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 EEA07938.1 - 0.00034 19.8 0.1 0.00066 18.9 0.0 1.5 2 0 0 2 2 2 1 Trehalose-phosphatase DUF3834 PF12916.7 EEA07938.1 - 0.0054 16.0 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3834) HAD_2 PF13419.6 EEA07938.1 - 0.016 15.3 0.1 1.1 9.3 0.0 2.8 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EEA07938.1 - 0.083 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like HAD PF12710.7 EEA07938.1 - 0.13 12.6 0.0 5.7 7.3 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EEA07939.1 - 7.4e-46 157.0 0.1 8.6e-46 156.7 0.1 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EEA07939.1 - 2.7e-16 59.9 0.0 8.8e-14 51.6 0.0 2.4 2 1 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EEA07939.1 - 1.5e-06 28.7 0.1 0.002 18.5 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EEA07939.1 - 0.0015 18.6 0.0 0.32 11.0 0.0 2.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EEA07939.1 - 0.002 18.6 0.0 0.36 11.2 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 EEA07939.1 - 0.019 14.1 0.0 0.048 12.8 0.0 1.6 2 0 0 2 2 2 0 Trehalose-phosphatase AbrB_C PF18277.1 EEA07939.1 - 0.039 13.6 0.1 0.19 11.4 0.1 2.2 1 1 0 1 1 1 0 AbrB C-terminal domain NurA PF09376.10 EEA07939.1 - 0.066 12.9 0.2 11 5.6 0.0 2.2 2 0 0 2 2 2 0 NurA domain TBCA PF02970.16 EEA07940.1 - 2.7e-16 59.7 1.9 5.4e-16 58.7 1.9 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor A CENP-F_leu_zip PF10473.9 EEA07940.1 - 0.0097 15.9 0.7 0.0097 15.9 0.7 1.6 1 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PC-Esterase PF13839.6 EEA07941.1 - 0.0046 16.7 2.7 0.0053 16.5 2.7 1.0 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p CbiA PF01656.23 EEA07941.1 - 0.93 9.6 3.5 2.7 8.1 3.5 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Peptidase_M41 PF01434.18 EEA07942.1 - 4.1e-58 196.4 0.0 6.6e-58 195.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EEA07942.1 - 3.1e-42 144.1 0.0 7.1e-42 143.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA07942.1 - 3.8e-09 36.2 0.1 8.5e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EEA07942.1 - 6.1e-06 26.6 0.8 2e-05 24.9 0.8 1.9 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 EEA07942.1 - 0.00011 22.2 0.0 0.00044 20.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EEA07942.1 - 0.00046 19.5 0.0 0.0011 18.3 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EEA07942.1 - 0.00052 20.3 0.0 0.062 13.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EEA07942.1 - 0.0016 18.2 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EEA07942.1 - 0.0034 17.5 0.0 0.016 15.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA07942.1 - 0.0064 16.9 0.1 0.025 15.0 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EEA07942.1 - 0.016 14.9 0.1 0.05 13.3 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EEA07942.1 - 0.04 13.3 0.1 0.085 12.2 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA07942.1 - 0.057 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA07942.1 - 0.083 13.4 0.5 0.55 10.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 EEA07942.1 - 0.14 12.5 0.0 0.38 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain CS PF04969.16 EEA07943.1 - 0.00023 22.1 3.4 0.00093 20.2 3.4 2.1 1 1 0 1 1 1 1 CS domain Ribosomal_L5e PF17144.4 EEA07943.1 - 0.018 15.0 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal large subunit proteins 60S L5, and 50S L18 zf-met PF12874.7 EEA07945.1 - 4.1e-05 23.8 0.4 4.1e-05 23.8 0.4 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type S6PP PF05116.13 EEA07946.1 - 1.9e-35 122.6 0.0 8.2e-17 61.6 0.0 3.2 2 1 1 3 3 3 3 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 EEA07946.1 - 6.5e-12 45.7 3.2 6.2e-11 42.5 3.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PPV_E1_N PF00524.18 EEA07947.1 - 0.027 14.9 1.2 0.15 12.5 0.6 2.2 1 1 1 2 2 2 0 E1 Protein, N terminal domain ZapB PF06005.12 EEA07948.1 - 0.0058 17.1 1.5 0.0058 17.1 1.5 9.7 6 4 1 7 7 7 2 Cell division protein ZapB PspB PF06667.12 EEA07948.1 - 0.071 13.2 13.9 0.44 10.6 0.4 5.0 4 0 0 4 4 4 0 Phage shock protein B Dsl1_N PF11988.8 EEA07949.1 - 0.14 11.2 0.2 0.17 10.8 0.2 1.1 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal Exostosin PF03016.15 EEA07952.1 - 4.6e-07 29.3 0.1 1.8e-06 27.4 0.0 1.8 2 0 0 2 2 2 1 Exostosin family TMEM101 PF15111.6 EEA07953.1 - 0.017 14.7 0.1 0.027 14.0 0.1 1.2 1 0 0 1 1 1 0 TMEM101 protein family DUF3800 PF12686.7 EEA07954.1 - 0.072 13.7 0.1 16 6.1 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) STAG PF08514.11 EEA07955.1 - 1.7e-07 31.1 0.6 2.7e-06 27.3 0.0 3.4 3 0 0 3 3 3 1 STAG domain Bax1-I PF01027.20 EEA07958.1 - 8.4e-30 104.2 32.7 9.8e-30 103.9 32.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CPP1-like PF11833.8 EEA07958.1 - 0.0012 18.5 4.5 0.0012 18.5 4.5 1.5 2 0 0 2 2 2 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like tRNA-synt_1b PF00579.25 EEA07959.1 - 5.6e-56 190.0 0.0 8.3e-56 189.4 0.0 1.3 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Folate_rec PF03024.14 EEA07960.1 - 3.3e-15 56.4 11.6 3.3e-15 56.4 11.6 1.8 1 1 1 2 2 2 1 Folate receptor family DUF2013 PF09431.10 EEA07961.1 - 0.0057 16.8 4.9 0.012 15.7 4.9 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2013) DUF4377 PF14302.6 EEA07961.1 - 0.055 13.5 0.5 0.11 12.6 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4377) Fer2 PF00111.27 EEA07962.1 - 1.4e-10 41.0 1.9 1.7e-10 40.7 1.9 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain RRM_1 PF00076.22 EEA07963.1 - 3.8e-77 254.1 0.0 1.1e-19 70.0 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EEA07963.1 - 1.7e-26 92.2 1.0 4.9e-26 90.7 1.0 1.9 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 EEA07963.1 - 1.1e-05 25.2 0.0 0.43 10.5 0.0 3.7 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EEA07963.1 - 1.5e-05 24.6 0.0 0.055 13.1 0.0 4.0 2 1 2 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EEA07963.1 - 0.00017 21.6 0.0 1.8 8.7 0.0 3.6 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 EEA07963.1 - 0.00019 21.4 0.0 3 7.9 0.0 4.2 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EEA07963.1 - 0.004 17.2 0.0 14 5.9 0.0 4.0 3 1 0 3 3 3 1 RNA recognition motif RNA_bind PF08675.11 EEA07963.1 - 0.005 16.8 0.0 2.6 8.1 0.0 3.4 3 1 0 3 3 3 1 RNA binding domain Nup35_RRM PF05172.13 EEA07963.1 - 0.058 13.4 0.0 14 5.7 0.0 3.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif CDC45 PF02724.14 EEA07963.1 - 2.8 6.1 7.9 4 5.6 7.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RCC1 PF00415.18 EEA07965.1 - 3.5e-32 110.8 2.9 2e-10 41.1 0.1 7.3 6 3 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EEA07965.1 - 4.3e-28 96.5 21.2 3.6e-08 33.0 0.3 5.9 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat zf-RING_UBOX PF13445.6 EEA07966.1 - 4.3e-09 36.3 5.1 9.7e-09 35.1 5.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EEA07966.1 - 5.4e-06 26.5 3.9 1.4e-05 25.2 3.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EEA07966.1 - 8e-06 25.7 4.1 1.6e-05 24.8 4.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EEA07966.1 - 1.7e-05 24.5 3.8 3.7e-05 23.5 3.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EEA07966.1 - 6e-05 23.3 5.1 0.00012 22.4 5.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EEA07966.1 - 9.2e-05 22.2 4.4 0.00019 21.2 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EEA07966.1 - 0.00013 21.8 6.2 0.00013 21.8 6.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA07966.1 - 0.00051 19.8 3.9 0.00072 19.4 2.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Peptidase_M41 PF01434.18 EEA07966.1 - 0.0094 15.8 0.3 0.029 14.2 0.3 1.8 1 0 0 1 1 1 1 Peptidase family M41 zf-MIZ PF02891.20 EEA07966.1 - 0.011 15.4 4.8 0.03 14.1 4.8 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_4 PF14570.6 EEA07966.1 - 0.14 11.9 3.6 0.33 10.8 3.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C2HC5 PF06221.13 EEA07966.1 - 0.21 11.6 2.9 0.53 10.3 2.9 1.7 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zf-RING_10 PF16685.5 EEA07966.1 - 2.1 8.6 6.9 0.27 11.4 1.8 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 DNA_Packaging PF11053.8 EEA07967.1 - 0.16 11.8 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Terminase DNA packaging enzyme Spectrin PF00435.21 EEA07969.1 - 0.0053 17.2 2.6 0.013 16.0 2.6 1.7 1 0 0 1 1 1 1 Spectrin repeat DUF948 PF06103.11 EEA07969.1 - 0.05 13.9 4.5 0.19 12.0 4.5 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HSBP1 PF06825.12 EEA07969.1 - 0.066 13.1 1.1 4.1 7.3 0.1 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 CotJB PF12652.7 EEA07971.1 - 0.088 13.0 0.4 0.46 10.7 0.1 2.3 2 0 0 2 2 2 0 CotJB protein zf-met2 PF12907.7 EEA07973.1 - 1.4e-17 63.5 3.3 2.1e-17 63.0 3.3 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 EEA07973.1 - 0.00038 21.3 2.5 0.00064 20.5 2.5 1.4 1 0 0 1 1 1 1 4F5 protein family zf-C2H2_4 PF13894.6 EEA07973.1 - 0.058 14.3 0.3 0.11 13.3 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger SWIRM-assoc_1 PF16495.5 EEA07976.1 - 0.37 10.8 3.9 2.9 7.9 0.2 3.1 2 0 0 2 2 2 0 SWIRM-associated region 1 DUF3744 PF12558.8 EEA07976.1 - 5.1 7.9 7.4 6.7 7.6 0.6 3.8 3 0 0 3 3 3 0 ATP-binding cassette cobalt transporter TAA-Trp-ring PF15401.6 EEA07977.1 - 0.029 14.8 1.5 0.12 12.8 0.8 2.2 2 0 0 2 2 2 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin Sec7 PF01369.20 EEA07978.1 - 2.7e-51 173.8 0.3 6.5e-51 172.6 0.3 1.7 1 0 0 1 1 1 1 Sec7 domain RabGAP-TBC PF00566.18 EEA07978.1 - 2.3e-30 105.8 3.3 2.3e-30 105.8 3.3 2.8 2 1 0 2 2 2 1 Rab-GTPase-TBC domain S-antigen PF05756.11 EEA07978.1 - 3.3 8.1 6.7 27 5.2 0.1 4.0 3 0 0 3 3 3 0 S-antigen protein Rad9 PF04139.13 EEA07979.1 - 3.1e-18 66.2 0.6 3.1e-18 66.2 0.6 1.5 2 0 0 2 2 2 1 Rad9 INCENP_ARK-bind PF03941.15 EEA07980.1 - 7.8e-13 48.2 0.4 2.3e-12 46.7 0.4 1.8 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region ApbE PF02424.15 EEA07980.1 - 0.098 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 ApbE family zf-NOSIP PF15906.5 EEA07981.1 - 3.2e-05 24.0 0.1 7.9e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 EEA07981.1 - 0.001 19.1 1.5 0.001 19.1 1.5 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA07981.1 - 0.0032 17.3 3.3 0.0032 17.3 3.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA07981.1 - 0.0042 16.9 4.1 0.015 15.1 4.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EEA07981.1 - 0.006 16.4 2.2 0.023 14.6 2.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Methyltransf_15 PF09445.10 EEA07981.1 - 0.035 13.7 0.5 0.043 13.4 0.5 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DZF PF07528.14 EEA07981.1 - 0.1 12.2 0.2 13 5.3 0.0 2.1 2 0 0 2 2 2 0 DZF domain zf-C3HC4_4 PF15227.6 EEA07981.1 - 0.36 11.0 5.5 0.42 10.8 2.1 2.6 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EEA07981.1 - 1.2 9.1 7.1 5.2 7.1 7.1 2.3 1 1 0 1 1 1 0 zinc-RING finger domain Sel1 PF08238.12 EEA07982.1 - 1.2e-30 105.3 23.3 2.5e-08 34.3 0.0 9.4 9 0 0 9 9 9 7 Sel1 repeat Ribosomal_S19 PF00203.21 EEA07983.1 - 1.6e-31 108.0 0.1 2.2e-31 107.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L4 PF00573.22 EEA07984.1 - 1e-38 133.0 0.0 1.7e-38 132.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EEA07984.1 - 3.9e-22 78.1 0.6 1.2e-21 76.5 0.6 1.8 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain Blt1 PF12754.7 EEA07984.1 - 0.27 11.6 1.2 2.3 8.5 1.2 2.2 1 1 0 1 1 1 0 Blt1 N-terminal domain TrbM PF07424.11 EEA07985.1 - 0.95 9.4 6.2 0.2 11.6 1.3 2.3 2 0 0 2 2 2 0 TrbM DEAD PF00270.29 EEA07986.1 - 6.7e-47 159.5 0.1 1.3e-46 158.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA07986.1 - 6.8e-29 100.5 2.1 8.8e-27 93.7 0.2 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EEA07986.1 - 1.5e-08 34.8 0.4 6e-08 32.9 0.0 2.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit S4 PF01479.25 EEA07986.1 - 0.024 14.4 0.2 11 5.8 0.0 3.4 3 0 0 3 3 3 0 S4 domain DUF1442 PF07279.11 EEA07986.1 - 0.038 13.3 0.1 0.081 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) PHD_like PF12910.7 EEA07986.1 - 0.13 12.3 0.1 0.7 9.9 0.0 2.2 2 1 1 3 3 3 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system Sugar_transport PF06800.12 EEA07987.1 - 0.15 11.3 0.1 0.22 10.8 0.1 1.1 1 0 0 1 1 1 0 Sugar transport protein Ras PF00071.22 EEA07988.1 - 3.5e-67 225.0 1.1 4.1e-67 224.8 1.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA07988.1 - 4.6e-37 126.9 1.1 5.6e-37 126.6 0.2 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA07988.1 - 1.9e-17 63.3 0.2 2.3e-17 63.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA07988.1 - 1.4e-06 27.9 0.1 1.6e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EEA07988.1 - 7.2e-06 25.7 0.5 1.9e-05 24.3 0.3 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EEA07988.1 - 1.7e-05 24.9 0.2 7.7e-05 22.7 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EEA07988.1 - 2.8e-05 24.1 0.3 0.13 12.1 0.0 2.4 1 1 2 3 3 3 2 RsgA GTPase SRPRB PF09439.10 EEA07988.1 - 0.00012 21.6 0.1 0.0002 20.8 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EEA07988.1 - 0.0063 16.1 0.1 0.091 12.3 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EEA07988.1 - 0.018 15.4 0.0 0.025 15.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EEA07988.1 - 0.027 14.0 0.2 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region NAGLU PF05089.12 EEA07988.1 - 0.028 13.4 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain AAA_22 PF13401.6 EEA07988.1 - 0.046 14.0 0.0 0.072 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EEA07988.1 - 0.056 13.4 0.0 0.096 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EEA07988.1 - 0.059 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain LANC_like PF05147.13 EEA07988.1 - 0.088 11.4 0.0 0.22 10.1 0.0 1.5 1 1 1 2 2 2 0 Lanthionine synthetase C-like protein ABC_tran PF00005.27 EEA07988.1 - 0.12 12.9 0.4 0.32 11.5 0.4 1.8 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EEA07988.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PYST-C1 PF09690.10 EEA07988.1 - 0.17 11.6 1.1 2.7 7.8 0.1 2.6 2 1 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) Methyltr_RsmB-F PF01189.17 EEA07989.1 - 1.6e-65 220.6 0.0 3e-65 219.6 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EEA07989.1 - 2.7e-08 34.2 0.0 6.6e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EEA07989.1 - 0.0011 19.1 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Gpi16 PF04113.14 EEA07990.1 - 3.5e-33 114.9 0.1 1.5e-32 112.9 0.1 1.7 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Bestrophin PF01062.21 EEA07991.1 - 0.017 14.5 0.1 0.031 13.7 0.1 1.4 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel RE_MjaI PF09568.10 EEA07991.1 - 0.025 14.4 1.6 2.2 8.1 0.0 2.8 2 1 0 3 3 3 0 MjaI restriction endonuclease DUF4272 PF14094.6 EEA07991.1 - 0.07 12.4 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) FapA PF03961.13 EEA07991.1 - 0.13 10.8 3.0 0.17 10.4 3.0 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_S PF02609.16 EEA07991.1 - 0.15 12.2 1.9 3.7 7.7 0.1 2.9 3 0 0 3 3 3 0 Exonuclease VII small subunit BLOC1_2 PF10046.9 EEA07991.1 - 1.5 9.2 6.1 1.6 9.1 0.1 3.4 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HARP PF07443.13 EEA07992.1 - 0.01 15.5 1.8 0.055 13.1 0.0 3.1 3 0 0 3 3 3 0 HepA-related protein (HARP) JAB PF01398.21 EEA07993.1 - 2.3e-32 111.5 0.0 4.5e-32 110.5 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EEA07993.1 - 9.4e-11 42.1 0.4 1.7e-10 41.3 0.4 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EEA07993.1 - 3.3e-10 39.8 0.0 5.2e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EEA07993.1 - 0.029 14.4 0.1 0.46 10.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) GST_N_2 PF13409.6 EEA07993.1 - 0.087 13.1 0.0 0.3 11.4 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain CBM_48 PF02922.18 EEA07994.1 - 5.8e-21 74.6 1.1 4.8e-20 71.7 0.1 3.1 4 0 0 4 4 4 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 EEA07994.1 - 4e-19 68.9 0.1 4.1e-18 65.6 0.1 2.6 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EEA07994.1 - 7.3e-11 42.2 0.1 0.0005 19.7 0.0 3.1 1 1 1 2 2 2 2 Alpha amylase, catalytic domain RNA_pol_Rpb1_5 PF04998.17 EEA07995.1 - 3.1e-86 289.1 0.1 5.4e-86 288.3 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EEA07995.1 - 1.6e-76 257.7 0.1 4.3e-76 256.2 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EEA07995.1 - 1e-70 237.2 0.0 2.4e-70 236.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EEA07995.1 - 8.5e-36 123.3 0.0 2.7e-35 121.6 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EEA07995.1 - 9.6e-30 102.7 0.0 4.2e-29 100.7 0.0 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 zf-CCCH PF00642.24 EEA07996.1 - 4.7e-09 35.9 2.7 4.7e-09 35.9 2.7 2.7 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EEA07996.1 - 2e-06 27.5 7.4 3.8e-06 26.7 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EEA07996.1 - 1.9e-05 24.5 11.9 3.7e-05 23.6 11.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf_CCCH_4 PF18345.1 EEA07996.1 - 2.9e-05 24.0 4.4 2.9e-05 24.0 4.4 2.4 2 0 0 2 2 2 1 Zinc finger domain zf-RING_10 PF16685.5 EEA07996.1 - 0.00025 21.1 6.2 0.00032 20.8 4.7 1.9 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 EEA07996.1 - 0.00095 19.1 9.7 0.0021 18.0 9.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EEA07996.1 - 0.0011 19.3 10.8 0.0011 19.3 10.8 1.8 2 0 0 2 2 1 1 Ring finger domain zf-CCCH_4 PF18044.1 EEA07996.1 - 0.0029 17.4 2.9 0.0029 17.4 2.9 2.6 2 0 0 2 2 2 1 CCCH-type zinc finger zf-C3HC4 PF00097.25 EEA07996.1 - 0.0029 17.4 11.1 0.0073 16.2 11.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA07996.1 - 0.03 14.2 9.9 0.066 13.1 9.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TALPID3 PF15324.6 EEA07996.1 - 0.15 9.7 0.6 0.21 9.2 0.0 1.4 2 0 0 2 2 2 0 Hedgehog signalling target Prok-RING_4 PF14447.6 EEA07996.1 - 0.25 11.3 8.2 0.49 10.3 8.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EEA07996.1 - 0.51 10.0 7.6 1.5 8.5 7.6 1.8 1 0 0 1 1 1 0 P-11 zinc finger zf-C3HC4_4 PF15227.6 EEA07996.1 - 3.1 8.0 9.2 25 5.1 9.6 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.6 EEA07996.1 - 6.3 7.4 8.5 1.6 9.3 2.8 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger PUB PF09409.10 EEA07997.1 - 6.9e-08 32.3 0.1 3.2e-07 30.2 0.0 2.2 3 0 0 3 3 3 1 PUB domain DUF202 PF02656.15 EEA07998.1 - 6.5e-14 52.1 1.4 1.5e-13 51.0 1.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 EEA07998.1 - 3.1e-13 50.4 8.9 3.3e-08 33.8 0.6 3.5 2 1 1 3 3 3 3 SPX domain VTC PF09359.10 EEA07998.1 - 5.4e-09 35.9 1.2 0.00031 20.2 0.0 3.1 3 0 0 3 3 3 2 VTC domain Ribosomal_L32e PF01655.18 EEA07999.1 - 3.3e-47 159.4 0.1 4.1e-47 159.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Glyco_transf_34 PF05637.12 EEA08000.1 - 0.0081 15.9 1.3 0.022 14.5 1.0 1.8 2 1 0 2 2 2 1 galactosyl transferase GMA12/MNN10 family KASH_CCD PF14662.6 EEA08001.1 - 0.0063 16.4 4.1 0.0063 16.4 4.1 2.1 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH Cnn_1N PF07989.11 EEA08001.1 - 0.0071 16.5 13.8 0.2 11.8 0.3 3.2 2 1 2 4 4 4 3 Centrosomin N-terminal motif 1 FYVE PF01363.21 EEA08001.1 - 0.0073 16.4 7.2 0.0073 16.4 7.2 1.9 2 0 0 2 2 1 1 FYVE zinc finger HAP1_N PF04849.13 EEA08001.1 - 0.039 13.2 15.7 0.12 11.6 15.7 1.7 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DZR PF12773.7 EEA08001.1 - 0.11 12.5 5.9 0.43 10.6 5.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon Csm1_N PF18504.1 EEA08001.1 - 0.84 10.0 10.2 0.72 10.2 1.1 3.1 3 0 0 3 3 3 0 Csm1 N-terminal domain GAS PF13851.6 EEA08001.1 - 0.94 8.8 13.7 0.63 9.3 7.7 2.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EEA08001.1 - 1.5 9.0 6.8 8.7 6.5 7.0 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) KLRAQ PF10205.9 EEA08001.1 - 2.6 8.4 13.4 0.12 12.6 1.2 3.7 2 1 2 4 4 4 0 Predicted coiled-coil domain-containing protein ZapB PF06005.12 EEA08001.1 - 2.8 8.5 16.5 0.12 12.8 4.2 3.3 2 1 1 3 3 3 0 Cell division protein ZapB CENP-F_leu_zip PF10473.9 EEA08001.1 - 3 7.9 15.0 0.55 10.3 7.3 2.5 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CLZ PF16526.5 EEA08001.1 - 3.3 8.1 7.0 5.5 7.4 0.3 3.0 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TolA_bind_tri PF16331.5 EEA08001.1 - 5.1 7.2 8.5 0.28 11.3 0.7 2.6 3 0 0 3 3 3 0 TolA binding protein trimerisation NLE PF08154.12 EEA08002.1 - 9.9e-17 61.2 0.1 2.2e-16 60.1 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 EEA08002.1 - 1.8e-08 34.9 16.0 0.058 14.3 3.2 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat eRF1_2 PF03464.15 EEA08003.1 - 1.3e-44 151.8 0.0 2.7e-44 150.7 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EEA08003.1 - 1.7e-39 134.8 0.2 3.6e-39 133.7 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EEA08003.1 - 2.2e-20 73.0 0.0 3.6e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EEA08003.1 - 8e-11 42.3 0.0 1.4e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EEA08003.1 - 1.2e-09 38.5 0.0 1.9e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Ribosomal_L7Ae PF01248.26 EEA08003.1 - 0.0093 15.7 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF5643 PF18705.1 EEA08003.1 - 0.054 13.5 0.0 0.2 11.6 0.0 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5643) PI3_PI4_kinase PF00454.27 EEA08004.1 - 6.3e-29 101.5 1.2 9.6e-27 94.4 0.4 3.0 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Pullulanase_Ins PF18494.1 EEA08004.1 - 0.44 11.1 3.0 6.9 7.2 0.1 3.2 2 0 0 2 2 2 0 Pullulanase Ins domain Exo_endo_phos PF03372.23 EEA08005.1 - 1.7e-22 80.1 0.0 5.6e-22 78.4 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C6H2 PF15801.5 EEA08005.1 - 0.17 12.2 3.6 0.45 10.9 3.6 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DUF676 PF05057.14 EEA08006.1 - 6.1e-22 78.2 0.0 2.8e-21 76.0 0.0 2.1 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EEA08006.1 - 0.0054 16.6 0.0 0.018 14.9 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) PGAP1 PF07819.13 EEA08006.1 - 0.018 14.8 0.7 0.069 12.9 0.1 2.2 2 1 0 2 2 2 0 PGAP1-like protein Syntaxin-6_N PF09177.11 EEA08007.1 - 8.6e-14 51.9 2.8 1.9e-13 50.8 0.4 2.1 2 0 0 2 2 2 1 Syntaxin 6, N-terminal Spc29 PF17082.5 EEA08007.1 - 0.15 11.9 9.6 0.66 9.8 4.1 2.3 1 1 1 2 2 2 0 Spindle Pole Component 29 Complex1_49kDa PF00346.19 EEA08007.1 - 0.58 9.2 3.2 0.73 8.9 3.1 1.4 1 1 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit FlaC_arch PF05377.11 EEA08007.1 - 4.5 7.7 11.8 2.2 8.7 0.7 3.6 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) A_deaminase PF00962.22 EEA08008.1 - 1.4e-90 303.9 0.0 2.2e-89 300.0 0.0 2.4 2 1 0 2 2 2 1 Adenosine/AMP deaminase DUF1965 PF09248.10 EEA08008.1 - 0.13 12.0 4.7 0.33 10.7 1.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1965) EF-hand_1 PF00036.32 EEA08008.1 - 0.17 11.5 1.6 0.34 10.6 0.1 2.4 2 0 0 2 2 2 0 EF hand Exo_endo_phos PF03372.23 EEA08012.1 - 8.2e-11 41.9 0.0 2.7e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family DEAD PF00270.29 EEA08013.1 - 3.1e-41 141.1 0.1 7.6e-41 139.8 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08013.1 - 6.6e-25 87.6 2.5 4.5e-24 84.9 0.0 3.3 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA08013.1 - 1.1e-11 44.8 0.1 7.5e-11 42.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EEA08013.1 - 1.1e-05 25.5 0.0 6.2e-05 23.1 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EEA08013.1 - 0.0016 17.7 0.2 0.0062 15.8 0.0 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase FoP_duplication PF13865.6 EEA08013.1 - 2.1 9.0 4.4 6.2 7.4 0.3 2.8 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Tctex-1 PF03645.13 EEA08014.1 - 2.4e-25 88.8 1.5 3.1e-25 88.4 1.5 1.2 1 0 0 1 1 1 1 Tctex-1 family KAR PF15222.6 EEA08014.1 - 0.013 15.8 0.3 0.022 15.0 0.3 1.4 1 0 0 1 1 1 0 Kidney androgen-regulated GST_C_3 PF14497.6 EEA08014.1 - 0.068 13.4 0.0 0.088 13.0 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Mating_N PF12731.7 EEA08014.1 - 0.095 12.8 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 Mating-type protein beta 1 FAM184 PF15665.5 EEA08015.1 - 0.00081 19.2 26.6 0.00081 19.2 26.6 3.2 2 1 1 3 3 3 1 Family with sequence similarity 184, A and B Tetraspanin PF00335.20 EEA08017.1 - 8.2 6.1 14.9 27 4.4 14.9 1.9 1 1 0 1 1 1 0 Tetraspanin family zf-RING_UBOX PF13445.6 EEA08018.1 - 0.0014 18.6 11.1 0.0036 17.3 11.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EEA08018.1 - 0.023 14.6 11.7 0.05 13.6 11.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EEA08018.1 - 0.092 12.6 10.5 0.22 11.4 10.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EEA08018.1 - 0.47 10.8 13.2 1.2 9.5 13.2 1.7 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 EEA08018.1 - 2 8.3 18.0 0.26 11.2 13.1 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EEA08018.1 - 3 7.8 15.7 0.16 11.9 5.0 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 AIM24 PF01987.17 EEA08019.1 - 0.0082 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF747 PF05346.11 EEA08020.1 - 4.1e-91 305.8 30.2 4.4e-82 276.1 16.0 2.5 3 0 0 3 3 3 2 Eukaryotic membrane protein family SH PF01445.17 EEA08020.1 - 0.054 13.5 0.9 0.32 11.0 0.9 2.4 1 0 0 1 1 1 0 Viral small hydrophobic protein PGAP1 PF07819.13 EEA08021.1 - 9.1e-07 28.8 0.5 1.2e-05 25.2 0.0 2.7 3 0 0 3 3 3 1 PGAP1-like protein Hydrolase_4 PF12146.8 EEA08021.1 - 0.088 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 AAA PF00004.29 EEA08022.1 - 2.1e-80 267.6 0.4 1.5e-47 161.3 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA08022.1 - 2.2e-19 69.0 0.3 4.5e-12 45.6 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 EEA08022.1 - 4.6e-12 46.4 0.2 8e-05 22.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EEA08022.1 - 4.7e-11 42.7 0.0 0.00033 20.4 0.0 3.6 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EEA08022.1 - 6.4e-10 39.7 0.0 0.0032 17.9 0.0 3.9 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 EEA08022.1 - 3.7e-08 33.0 0.5 0.003 16.8 0.0 3.8 4 0 0 4 4 4 2 TIP49 P-loop domain AAA_5 PF07728.14 EEA08022.1 - 5.4e-08 32.9 0.6 0.034 14.2 0.2 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA08022.1 - 8.1e-07 29.4 5.9 0.009 16.3 0.1 5.4 3 2 1 4 4 3 1 AAA domain Mg_chelatase PF01078.21 EEA08022.1 - 8.2e-06 25.3 0.1 0.024 14.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA08022.1 - 2.5e-05 24.6 0.0 0.33 11.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EEA08022.1 - 2.9e-05 24.1 1.7 0.31 11.1 0.1 3.2 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EEA08022.1 - 3.7e-05 24.3 0.1 0.0086 16.6 0.1 3.3 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EEA08022.1 - 8.2e-05 22.4 0.0 0.29 10.9 0.0 3.0 2 1 1 3 3 3 2 IstB-like ATP binding protein AAA_24 PF13479.6 EEA08022.1 - 0.00014 21.6 0.0 0.0046 16.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EEA08022.1 - 0.00019 21.9 0.0 0.081 13.4 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 EEA08022.1 - 0.00063 19.3 0.0 0.58 9.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 EEA08022.1 - 0.0011 19.1 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EEA08022.1 - 0.0012 18.4 0.0 1.4 8.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EEA08022.1 - 0.0019 17.9 0.0 0.5 10.1 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 EEA08022.1 - 0.002 18.1 0.0 0.076 12.9 0.0 2.9 3 1 0 3 3 3 1 NACHT domain Rad17 PF03215.15 EEA08022.1 - 0.0022 17.9 0.0 0.27 11.1 0.0 2.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_3 PF07726.11 EEA08022.1 - 0.0023 17.8 0.0 2.6 7.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EEA08022.1 - 0.0024 17.9 0.0 0.75 9.8 0.0 2.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EEA08022.1 - 0.0025 16.9 0.0 0.069 12.2 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Vps4_C PF09336.10 EEA08022.1 - 0.0096 15.9 0.5 0.34 10.9 0.0 3.2 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain ATPase PF06745.13 EEA08022.1 - 0.0099 15.3 0.0 4.4 6.6 0.0 2.8 2 0 0 2 2 2 1 KaiC AAA_19 PF13245.6 EEA08022.1 - 0.013 15.8 0.2 0.28 11.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EEA08022.1 - 0.014 14.6 0.1 1.3 8.1 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain AAA_11 PF13086.6 EEA08022.1 - 0.019 14.7 0.1 2.7 7.7 0.0 3.0 2 1 0 3 3 3 0 AAA domain AAA_17 PF13207.6 EEA08022.1 - 0.02 15.3 0.1 12 6.3 0.1 3.3 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 EEA08022.1 - 0.028 13.9 0.1 1.8 8.0 0.0 2.8 3 0 0 3 3 2 0 PhoH-like protein Sigma54_activ_2 PF14532.6 EEA08022.1 - 0.043 13.9 0.7 11 6.2 0.0 3.5 4 0 0 4 4 3 0 Sigma-54 interaction domain UvrD-helicase PF00580.21 EEA08022.1 - 2.8 7.3 7.3 0.67 9.4 0.7 3.0 3 1 0 3 3 3 0 UvrD/REP helicase N-terminal domain CBFD_NFYB_HMF PF00808.23 EEA08023.1 - 9.3e-16 57.9 0.0 1.7e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Cnd1 PF12717.7 EEA08024.1 - 4.5e-09 36.6 1.9 4.5e-09 36.6 1.9 4.7 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 NOG1_N PF17835.1 EEA08025.1 - 3.8e-49 166.7 0.9 9.6e-49 165.4 0.1 2.2 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 EEA08025.1 - 1.5e-26 91.9 0.1 5.4e-26 90.1 0.1 2.1 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 EEA08025.1 - 9.7e-24 83.1 3.4 2.2e-23 82.0 3.4 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 EEA08025.1 - 4.3e-18 65.5 0.0 1.5e-17 63.7 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA08025.1 - 2e-10 40.4 0.0 4.1e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA08025.1 - 0.0053 16.8 0.1 1.5 8.8 0.0 2.7 1 1 1 2 2 2 1 Dynamin family AIG1 PF04548.16 EEA08025.1 - 0.018 14.4 0.0 0.049 13.0 0.0 1.8 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 EEA08025.1 - 0.031 14.2 0.1 1.3 8.9 0.0 3.2 2 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EEA08025.1 - 0.099 13.0 0.2 0.75 10.2 0.0 2.6 2 2 0 2 2 2 0 AAA ATPase domain FAM199X PF15814.5 EEA08025.1 - 0.21 10.6 3.0 0.4 9.7 3.0 1.4 1 0 0 1 1 1 0 Protein family FAM199X AAA_18 PF13238.6 EEA08025.1 - 2 9.0 0.0 2 9.0 0.0 3.5 4 1 0 4 4 4 0 AAA domain Peptidase_M16_C PF05193.21 EEA08026.1 - 5.5e-12 46.1 2.4 5.8e-08 33.0 0.1 3.3 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA08026.1 - 3.1e-10 40.2 0.1 1.5e-09 38.0 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EEA08026.1 - 0.0004 19.8 17.4 0.00043 19.7 2.6 3.1 3 0 0 3 3 3 2 Middle or third domain of peptidase_M16 DoxA PF07680.11 EEA08026.1 - 0.011 15.6 2.5 0.013 15.4 0.3 2.3 2 0 0 2 2 2 0 TQO small subunit DoxA Peptidase_M16_C PF05193.21 EEA08027.1 - 4.3e-10 39.9 4.3 5e-10 39.7 0.1 2.8 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA08027.1 - 2.7e-09 37.2 0.0 6.5e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) EF-hand_1 PF00036.32 EEA08030.1 - 1.9e-33 111.5 14.1 3.4e-08 32.5 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EEA08030.1 - 4.6e-29 100.7 11.3 3.3e-14 53.1 3.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA08030.1 - 4.8e-27 91.5 9.7 1.3e-07 31.0 0.0 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EEA08030.1 - 4e-19 68.2 9.4 1.5e-09 37.5 1.2 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EEA08030.1 - 2e-14 53.6 0.9 4.6e-06 26.9 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EEA08030.1 - 1.3e-12 46.5 12.1 0.00078 18.8 1.6 4.7 4 1 1 5 5 5 4 EF hand EF-hand_4 PF12763.7 EEA08030.1 - 2.1e-05 24.4 4.9 0.012 15.5 0.1 2.5 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EEA08030.1 - 0.00041 20.7 2.4 0.18 12.1 0.4 2.5 1 1 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 EEA08030.1 - 0.0007 20.4 1.3 0.24 12.3 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain Caleosin PF05042.13 EEA08030.1 - 0.00072 19.5 0.9 5.3 6.9 0.0 3.8 1 1 3 4 4 4 1 Caleosin related protein Gp-FAR-1 PF05823.12 EEA08030.1 - 0.0043 17.4 6.2 0.11 12.9 0.1 3.1 2 1 1 3 3 3 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1636 PF07845.11 EEA08030.1 - 0.0095 16.4 0.0 0.54 10.7 0.0 3.0 1 1 3 4 4 4 1 Protein of unknown function (DUF1636) Ribosomal_L12 PF00542.19 EEA08030.1 - 0.0097 16.2 1.4 0.16 12.3 0.0 2.9 2 1 1 3 3 3 1 Ribosomal protein L7/L12 C-terminal domain HTH_40 PF14493.6 EEA08030.1 - 0.029 14.8 4.6 1.9 9.0 0.3 2.5 1 1 1 2 2 2 0 Helix-turn-helix domain SurA_N_2 PF13623.6 EEA08030.1 - 0.03 14.2 2.5 1.3 8.9 0.1 2.6 1 1 1 2 2 2 0 SurA N-terminal domain Mst1_SARAH PF11629.8 EEA08030.1 - 0.032 14.3 2.7 0.12 12.5 2.8 2.0 2 0 0 2 2 1 0 C terminal SARAH domain of Mst1 MgtE_N PF03448.17 EEA08030.1 - 0.086 13.5 4.9 0.17 12.5 1.5 2.3 2 0 0 2 2 2 0 MgtE intracellular N domain SurA_N_3 PF13624.6 EEA08030.1 - 0.12 12.2 5.2 0.23 11.3 0.8 2.1 1 1 1 2 2 2 0 SurA N-terminal domain PhetRS_B1 PF18262.1 EEA08030.1 - 0.29 11.4 3.3 0.18 12.1 0.6 2.0 2 1 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain SHOCT PF09851.9 EEA08030.1 - 1.6 8.6 8.1 1.7 8.5 0.2 3.8 4 0 0 4 4 4 0 Short C-terminal domain Arg_decarbox_C PF17944.1 EEA08030.1 - 1.9 9.1 4.3 24 5.6 0.1 3.2 3 0 0 3 3 3 0 Arginine decarboxylase C-terminal helical extension PEPcase PF00311.17 EEA08031.1 - 5.3e-226 752.4 4.8 1.9e-132 443.0 1.3 4.3 3 1 0 3 3 3 3 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 EEA08031.1 - 2e-05 23.3 0.0 0.00098 17.7 0.0 2.2 2 0 0 2 2 2 2 Phosphoenolpyruvate carboxylase TFIIA PF03153.13 EEA08032.1 - 3.3 7.6 21.7 3.8 7.4 21.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Thioredoxin PF00085.20 EEA08033.1 - 5.9e-17 61.5 0.0 7.9e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.24 EEA08033.1 - 1.7e-05 24.9 0.0 4.7e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_8 PF13905.6 EEA08033.1 - 0.00019 21.7 0.1 0.0048 17.2 0.0 2.5 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EEA08033.1 - 0.013 15.3 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_6 PF13848.6 EEA08033.1 - 0.014 15.3 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain DNA_pol_A_exo1 PF01612.20 EEA08035.1 - 7.9e-36 123.4 0.0 1.8e-35 122.2 0.0 1.6 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 EEA08035.1 - 3.8e-06 26.8 0.0 1.7e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 HRDC domain DUF2024 PF09630.10 EEA08035.1 - 0.6 10.0 3.8 0.32 10.9 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) MazG-like PF12643.7 EEA08036.1 - 1.1e-12 48.1 0.4 1.6e-12 47.5 0.4 1.3 1 0 0 1 1 1 1 MazG-like family MazG PF03819.17 EEA08036.1 - 6.2e-05 23.1 0.3 0.00012 22.2 0.2 1.6 2 0 0 2 2 2 1 MazG nucleotide pyrophosphohydrolase domain Vif PF00559.17 EEA08036.1 - 0.029 14.1 0.1 0.035 13.8 0.1 1.3 1 1 0 1 1 1 0 Retroviral Vif (Viral infectivity) protein Myb_Cef PF11831.8 EEA08037.1 - 8.5e-20 71.3 3.1 8.5e-20 71.3 3.1 3.0 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EEA08037.1 - 8e-19 67.6 5.4 3.2e-11 43.2 1.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA08037.1 - 4.7e-14 52.4 5.1 1.3e-10 41.3 2.2 4.1 4 1 1 5 5 5 2 Myb-like DNA-binding domain Herpes_UL79 PF03049.14 EEA08037.1 - 0.041 13.5 0.2 0.1 12.2 0.2 1.6 1 0 0 1 1 1 0 UL79 family tRNA_m1G_MT PF01746.21 EEA08038.1 - 1.6e-14 54.0 0.0 3.4e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase C2 PF00168.30 EEA08039.1 - 5.6e-28 97.2 0.0 3e-08 33.9 0.0 6.3 6 0 0 6 6 6 4 C2 domain PI3K_C2 PF00792.24 EEA08039.1 - 0.0075 16.2 0.0 0.051 13.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 Ferlin_C PF16165.5 EEA08039.1 - 0.019 14.9 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Ferlin C-terminus ArfGap PF01412.18 EEA08040.1 - 1e-24 86.8 0.7 2.1e-24 85.8 0.7 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EEA08040.1 - 4.7e-05 23.4 1.2 8.4e-05 22.6 1.2 1.4 1 0 0 1 1 1 1 B-box zinc finger SNF2_N PF00176.23 EEA08041.1 - 1e-25 90.2 2.9 8.4e-25 87.2 2.9 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA08041.1 - 2.1e-10 40.9 0.3 9.5e-10 38.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08041.1 - 1.5e-07 31.6 0.0 1.5e-07 31.6 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EEA08041.1 - 0.012 15.6 0.0 0.026 14.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain ATP-synt_ab PF00006.25 EEA08041.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain PCRF PF03462.18 EEA08041.1 - 0.93 9.3 3.7 0.57 10.0 0.2 2.2 2 0 0 2 2 2 0 PCRF domain NADH-u_ox-rdase PF10785.9 EEA08042.1 - 0.056 14.1 0.2 0.1 13.3 0.2 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Rdx PF10262.9 EEA08044.1 - 1e-07 32.0 0.0 2e-07 31.1 0.0 1.5 1 1 0 1 1 1 1 Rdx family tRNA_anti-codon PF01336.25 EEA08045.1 - 1.2e-07 31.6 0.0 1.9e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain LSM PF01423.22 EEA08046.1 - 0.023 14.4 0.7 0.15 11.8 0.1 2.2 2 0 0 2 2 2 0 LSM domain COMP PF11598.8 EEA08048.1 - 4.3 7.9 5.9 11 6.6 0.5 2.6 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein MBF1 PF08523.10 EEA08049.1 - 1.9e-18 66.6 1.2 1.9e-18 66.6 1.2 1.6 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EEA08049.1 - 8e-12 45.0 0.1 1.3e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 EEA08049.1 - 0.00022 21.2 0.1 0.00039 20.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 EEA08049.1 - 0.00025 21.3 0.0 0.0004 20.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 EEA08049.1 - 0.053 13.4 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_37 PF13744.6 EEA08049.1 - 0.057 13.4 0.1 0.088 12.8 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain EF-hand_1 PF00036.32 EEA08050.1 - 9.1e-09 34.3 4.0 0.00024 20.4 0.1 3.3 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EEA08050.1 - 3.2e-07 30.7 0.6 0.029 14.8 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA08050.1 - 7.5e-07 28.6 2.5 0.0031 17.3 0.1 3.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EEA08050.1 - 1.8e-05 24.5 3.8 0.34 10.8 0.0 3.7 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 EEA08050.1 - 0.00027 21.2 0.2 0.47 10.8 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EEA08050.1 - 0.00035 20.5 0.5 0.0018 18.2 0.0 2.2 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 EEA08050.1 - 0.019 14.5 0.9 0.019 14.5 0.9 2.5 3 0 0 3 3 3 0 EF hand TerB PF05099.13 EEA08050.1 - 0.029 14.3 0.0 6.9 6.6 0.0 2.4 2 1 0 2 2 2 0 Tellurite resistance protein TerB HSP90 PF00183.18 EEA08051.1 - 2.1e-230 766.0 26.5 2.5e-230 765.8 26.5 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EEA08051.1 - 1.7e-15 57.5 0.2 3.3e-15 56.5 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EEA08051.1 - 5.3e-11 42.5 0.2 1.4e-10 41.1 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 EEA08051.1 - 0.027 14.5 0.1 0.11 12.6 0.1 2.0 1 0 0 1 1 1 0 Tumour suppressor protein ComK PF06338.11 EEA08051.1 - 0.052 13.2 0.2 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 ComK protein Ribosomal_S20p PF01649.18 EEA08051.1 - 0.078 13.6 1.8 0.2 12.3 0.6 2.4 2 0 0 2 2 2 0 Ribosomal protein S20 AAA PF00004.29 EEA08052.1 - 2e-10 41.2 2.5 4.8e-05 23.8 0.2 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Ribosomal_L19e PF01280.20 EEA08053.1 - 8.6e-59 197.7 10.5 1.3e-58 197.1 10.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L19e IL2 PF00715.17 EEA08053.1 - 0.2 11.6 0.7 2.7 7.9 0.1 2.1 2 0 0 2 2 2 0 Interleukin 2 WD40 PF00400.32 EEA08054.1 - 5.9e-06 26.9 5.3 0.021 15.7 0.1 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat GATA PF00320.27 EEA08054.1 - 0.31 10.7 7.0 0.77 9.4 7.0 1.7 1 0 0 1 1 1 0 GATA zinc finger Clat_adaptor_s PF01217.20 EEA08055.1 - 6.7e-26 90.9 6.5 7.3e-26 90.8 6.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DNA_ligase_A_M PF01068.21 EEA08056.1 - 1.3e-60 204.6 0.6 1.3e-60 204.6 0.6 2.5 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EEA08056.1 - 5.6e-36 124.5 0.0 1.3e-35 123.3 0.0 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EEA08056.1 - 1.7e-22 79.8 0.0 3.3e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EEA08056.1 - 2e-05 25.0 0.4 3.6e-05 24.1 0.4 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 EEA08056.1 - 0.0014 18.5 0.6 0.063 13.1 0.1 2.6 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain PUB PF09409.10 EEA08057.1 - 3.6e-16 58.9 1.6 1.2e-15 57.2 1.6 1.9 1 0 0 1 1 1 1 PUB domain tRNA-synt_1 PF00133.22 EEA08058.1 - 2.8e-214 712.8 0.0 1.1e-213 710.8 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EEA08058.1 - 9.8e-26 90.5 0.1 1e-23 84.0 0.2 2.5 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EEA08058.1 - 9.7e-18 64.1 2.8 3.2e-05 22.9 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EEA08058.1 - 2.4e-06 27.1 0.8 8e-05 22.1 0.0 3.3 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain Taeniidae_ag PF05596.11 EEA08058.1 - 0.12 12.4 1.4 3 7.9 0.0 3.1 2 0 0 2 2 2 0 Taeniidae antigen DKCLD PF08068.12 EEA08059.1 - 3.6e-32 110.2 0.1 2.6e-31 107.5 0.3 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EEA08059.1 - 1.5e-20 73.0 1.2 3.1e-20 72.1 1.2 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EEA08059.1 - 5.8e-20 72.2 5.8 6.4e-18 65.6 0.2 3.7 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EEA08059.1 - 2.9e-19 68.8 2.3 6.2e-19 67.7 2.3 1.6 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EEA08059.1 - 0.026 14.8 0.1 0.08 13.2 0.1 1.9 1 0 0 1 1 1 0 UPF0113 PUA domain Nuf2 PF03800.14 EEA08060.1 - 4.5e-30 104.6 0.1 4.5e-30 104.6 0.1 2.8 3 2 0 3 3 3 1 Nuf2 family DHR10 PF18595.1 EEA08060.1 - 0.00084 19.4 19.6 0.00084 19.4 19.6 4.2 1 1 3 4 4 4 2 Designed helical repeat protein 10 domain Filament PF00038.21 EEA08060.1 - 0.0012 18.5 50.7 0.0053 16.4 11.5 3.6 1 1 2 3 3 3 2 Intermediate filament protein DUF3584 PF12128.8 EEA08060.1 - 0.26 8.8 45.1 0.36 8.3 45.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BRE1 PF08647.11 EEA08060.1 - 0.6 10.2 50.0 0.2 11.7 6.8 4.6 1 1 3 4 4 4 0 BRE1 E3 ubiquitin ligase GAS PF13851.6 EEA08060.1 - 0.87 8.9 54.7 5.5 6.3 14.7 3.7 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EEA08060.1 - 1.1 9.4 62.7 3.9 7.5 17.4 4.0 1 1 3 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus WD40_alt PF14077.6 EEA08060.1 - 1.3 9.0 6.7 3.2 7.7 2.4 2.7 2 0 0 2 2 2 0 Alternative WD40 repeat motif Tropomyosin PF00261.20 EEA08060.1 - 3.6 6.9 45.9 16 4.7 4.4 3.2 1 1 1 2 2 2 0 Tropomyosin Fez1 PF06818.15 EEA08060.1 - 5.5 7.4 43.8 0.62 10.5 19.5 3.0 1 1 3 4 4 4 0 Fez1 MCPsignal PF00015.21 EEA08060.1 - 6.5 6.5 14.4 9.4 6.0 1.6 3.3 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF745 PF05335.13 EEA08060.1 - 8.1 6.1 31.0 28 4.4 11.5 3.3 1 1 0 2 2 2 0 Protein of unknown function (DUF745) GTP_EFTU PF00009.27 EEA08062.1 - 3.1e-42 144.3 0.0 6.6e-42 143.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EEA08062.1 - 3.5e-28 98.6 7.4 6.8e-28 97.7 7.4 1.5 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_C PF00679.24 EEA08062.1 - 3.7e-21 74.9 0.0 1.4e-20 73.1 0.0 2.1 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EEA08062.1 - 6.2e-21 74.4 0.0 1.4e-20 73.2 0.0 1.7 1 1 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 EEA08062.1 - 2.6e-12 46.9 0.0 5.5e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EEA08062.1 - 3.6e-07 30.2 0.0 7.6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EEA08062.1 - 1.7e-06 28.1 0.4 3.8e-06 27.0 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EEA08062.1 - 0.045 14.0 0.0 0.84 9.9 0.0 2.5 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EEA08062.1 - 0.079 13.0 0.0 4.7 7.2 0.0 2.7 1 1 1 2 2 2 0 Dynamin family Ras PF00071.22 EEA08062.1 - 0.085 12.5 0.0 0.26 10.9 0.0 1.8 1 0 0 1 1 1 0 Ras family Ribosomal_L7Ae PF01248.26 EEA08063.1 - 3.9e-22 77.8 0.0 4.4e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DPBB_1 PF03330.18 EEA08063.1 - 0.02 15.2 0.4 2 8.8 0.1 2.1 1 1 1 2 2 2 0 Lytic transglycolase GUCT PF08152.12 EEA08064.1 - 6.3e-07 29.6 1.0 2.3 8.6 0.0 6.7 2 1 5 8 8 8 4 GUCT (NUC152) domain DUF824 PF05688.11 EEA08064.1 - 0.055 13.3 0.4 19 5.2 0.0 4.3 4 0 0 4 4 4 0 Salmonella repeat of unknown function (DUF824) 2OG-FeII_Oxy_3 PF13640.6 EEA08065.1 - 2e-07 31.8 0.0 3.7e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 EEA08065.1 - 0.061 13.5 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DEAD PF00270.29 EEA08066.1 - 7.2e-47 159.4 0.1 3.7e-46 157.1 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08066.1 - 8e-24 84.1 0.0 5.7e-23 81.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EEA08066.1 - 9.9e-18 64.1 0.2 1.9e-17 63.3 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EEA08066.1 - 8.1e-05 22.7 0.1 0.00074 19.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EEA08066.1 - 0.07 12.6 0.2 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 EEA08066.1 - 0.082 12.6 0.0 2 8.1 0.0 2.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EEA08066.1 - 0.2 11.9 0.9 1.7 8.9 0.3 2.7 2 2 0 2 2 2 0 AAA domain Ribosomal_L27A PF00828.19 EEA08067.1 - 1.4e-19 71.0 0.0 1.9e-19 70.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF5026 PF16429.5 EEA08067.1 - 0.15 12.1 0.5 0.24 11.5 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5026) PUB PF09409.10 EEA08069.1 - 2e-21 75.7 0.8 7.8e-21 73.8 0.3 2.1 2 0 0 2 2 2 1 PUB domain UBA PF00627.31 EEA08069.1 - 0.0098 15.8 0.1 0.025 14.5 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain FAM76 PF16046.5 EEA08069.1 - 3 7.1 17.4 5.4 6.3 17.4 1.5 1 1 0 1 1 1 0 FAM76 protein V_ATPase_I PF01496.19 EEA08069.1 - 5.7 4.7 8.1 7.8 4.3 8.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnd2 PF05786.14 EEA08070.1 - 1.1e-18 67.3 26.0 8.5e-10 38.0 2.2 3.8 4 0 0 4 4 4 3 Condensin complex subunit 2 CNDH2_N PF06278.11 EEA08070.1 - 0.0011 19.1 4.0 0.0028 17.9 2.0 2.6 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DnaB PF00772.21 EEA08070.1 - 0.15 12.1 3.1 1.1 9.3 0.2 3.6 3 0 0 3 3 3 0 DnaB-like helicase N terminal domain RRM_1 PF00076.22 EEA08071.1 - 2.7e-13 49.5 0.0 4.7e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EEA08071.1 - 0.031 13.9 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA08071.1 - 0.098 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Pre-PUA PF17832.1 EEA08072.1 - 1.2e-25 90.0 0.1 2.1e-25 89.2 0.1 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EEA08072.1 - 1.7e-17 63.2 0.0 2.5e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 EEA08072.1 - 0.059 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) T6SS_VipA PF05591.12 EEA08073.1 - 0.059 13.2 0.8 0.15 11.9 0.1 2.0 2 0 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 Eapp_C PF10238.9 EEA08074.1 - 0.03 14.4 0.3 13 5.8 0.0 3.0 3 0 0 3 3 3 0 E2F-associated phosphoprotein Yippee-Mis18 PF03226.14 EEA08074.1 - 0.19 12.0 3.9 0.54 10.5 1.8 2.6 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly CS PF04969.16 EEA08076.1 - 4.5e-11 43.6 3.7 4.5e-11 43.6 3.7 2.4 3 0 0 3 3 3 1 CS domain Siah-Interact_N PF09032.11 EEA08076.1 - 1.2e-07 31.9 2.6 1.2e-07 31.9 2.6 1.9 2 0 0 2 2 2 1 Siah interacting protein, N terminal SGS PF05002.15 EEA08076.1 - 0.00082 19.4 1.4 0.00082 19.4 1.4 1.9 2 0 0 2 2 2 1 SGS domain DUF4945 PF16303.5 EEA08076.1 - 0.029 14.3 3.3 0.062 13.2 1.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4945) Vac_ImportDeg PF09783.9 EEA08076.1 - 0.031 14.1 1.2 0.054 13.3 1.2 1.4 1 0 0 1 1 1 0 Vacuolar import and degradation protein DUF5442 PF17514.2 EEA08076.1 - 1.5 9.1 8.1 0.39 10.9 3.9 2.3 2 1 1 3 3 3 0 Family of unknown function (DUF5442) Pih1_fungal_CS PF18482.1 EEA08076.1 - 3.3 8.3 10.3 0.28 11.7 4.0 2.4 1 1 2 3 3 3 0 Fungal Pih1 CS domain YabA PF06156.13 EEA08076.1 - 7.4 7.3 7.2 20 5.9 0.3 2.9 1 1 2 3 3 3 0 Initiation control protein YabA CSN8_PSD8_EIF3K PF10075.9 EEA08077.1 - 1.5e-25 89.8 0.0 2e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Bax1-I PF01027.20 EEA08078.1 - 2.6e-37 128.7 33.6 3e-37 128.5 33.6 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2721 PF11026.8 EEA08078.1 - 0.0033 17.3 0.2 0.0033 17.3 0.2 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2721) Cyclin_N PF00134.23 EEA08080.1 - 1.7e-27 95.7 0.1 3.3e-27 94.7 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EEA08080.1 - 0.0076 16.3 0.3 0.015 15.4 0.3 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain Hira PF07569.11 EEA08081.1 - 1.2e-10 41.5 0.1 8.2e-10 38.8 0.1 2.4 3 0 0 3 3 3 1 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 EEA08081.1 - 2e-07 31.2 2.7 0.073 13.4 0.1 5.7 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA08081.1 - 0.0044 17.8 0.0 38 5.4 0.0 4.4 3 0 0 3 3 3 1 WD domain, G-beta repeat Sugar_tr PF00083.24 EEA08082.1 - 2.2e-55 188.3 32.0 2.6e-55 188.1 32.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA08082.1 - 1.9e-27 96.1 26.5 1.9e-19 69.8 5.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Thioredoxin_7 PF13899.6 EEA08083.1 - 5.2e-08 33.0 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EEA08083.1 - 7.1e-07 28.9 0.1 1.4e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain zf-UBR PF02207.20 EEA08084.1 - 2.6e-18 66.0 17.9 2.6e-18 66.0 17.9 2.8 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-RING_5 PF14634.6 EEA08084.1 - 0.016 15.2 0.3 0.016 15.2 0.3 3.9 4 0 0 4 4 4 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EEA08084.1 - 0.017 15.1 0.1 0.075 13.1 0.1 2.2 1 0 0 1 1 1 0 RING-type zinc-finger Ribosomal_S8e PF01201.22 EEA08085.1 - 5.5e-49 165.8 2.9 5.5e-49 165.8 2.9 2.1 1 1 1 2 2 2 1 Ribosomal protein S8e DUF3746 PF12562.8 EEA08085.1 - 0.24 11.4 3.4 0.32 10.9 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3746) CASP_C PF08172.12 EEA08085.1 - 0.39 10.0 5.5 0.54 9.6 5.5 1.2 1 0 0 1 1 1 0 CASP C terminal TFIID_30kDa PF03540.13 EEA08087.1 - 0.00082 19.3 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit ANAPC4_WD40 PF12894.7 EEA08088.1 - 0.0013 19.0 0.7 0.024 14.9 0.0 3.0 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EEA08088.1 - 0.087 13.7 0.2 0.98 10.4 0.1 2.8 2 0 0 2 2 2 0 WD domain, G-beta repeat Serine_rich PF08824.10 EEA08088.1 - 0.12 12.4 0.1 0.77 9.8 0.0 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain DegQ PF08181.11 EEA08088.1 - 0.52 10.5 3.7 20 5.4 0.1 3.4 2 1 1 3 3 3 0 DegQ (SacQ) family E1-E2_ATPase PF00122.20 EEA08089.1 - 5.6e-24 84.6 0.9 1.6e-18 66.9 0.0 3.2 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase PF13246.6 EEA08089.1 - 2.2e-07 30.9 0.0 5.9e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EEA08089.1 - 4.3e-05 23.9 0.0 3.8 7.7 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EEA08089.1 - 0.00046 19.8 0.0 0.0015 18.2 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus RRM_1 PF00076.22 EEA08090.1 - 7.1e-33 112.2 0.0 1e-16 60.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EEA08090.1 - 0.00024 20.9 0.0 0.0023 17.8 0.0 2.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EEA08090.1 - 0.0045 17.0 0.0 1 9.4 0.0 3.0 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 EEA08090.1 - 0.16 12.0 0.0 2.4 8.2 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-CCHC PF00098.23 EEA08091.1 - 2.2e-12 46.5 36.9 1.8e-06 27.7 2.4 4.6 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_4 PF14392.6 EEA08091.1 - 0.043 13.6 26.4 1.1 9.0 1.6 4.3 4 0 0 4 4 4 0 Zinc knuckle zf-CHC2 PF01807.20 EEA08091.1 - 0.15 11.9 0.1 0.15 11.9 0.1 3.2 1 1 2 3 3 3 0 CHC2 zinc finger Myosin_head PF00063.21 EEA08092.1 - 1.4e-126 423.4 30.1 2.8e-103 346.4 11.9 6.8 4 2 0 4 4 4 2 Myosin head (motor domain) AAA_22 PF13401.6 EEA08092.1 - 0.06 13.6 0.7 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Brr6_like_C_C PF10104.9 EEA08093.1 - 2.8e-44 150.1 1.6 2.8e-44 150.1 1.6 2.0 2 0 0 2 2 2 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF4064 PF13273.6 EEA08093.1 - 0.02 15.1 0.8 4.8 7.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF3603 PF12227.8 EEA08093.1 - 0.046 13.0 0.1 0.074 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3603) EphA2_TM PF14575.6 EEA08094.1 - 0.21 12.5 1.5 1.2 10.1 0.5 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.11 EEA08094.1 - 0.96 9.1 5.6 5.1 6.8 0.2 2.7 2 1 1 3 3 3 0 Baculovirus 11 kDa family LSM PF01423.22 EEA08095.1 - 4.5e-16 58.3 0.1 5.2e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain Chordopox_A35R PF05989.12 EEA08095.1 - 0.0037 17.2 0.0 0.0049 16.8 0.0 1.1 1 0 0 1 1 1 1 Chordopoxvirus A35R protein Hfq PF17209.3 EEA08095.1 - 0.02 14.5 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Thioredoxin PF00085.20 EEA08096.1 - 7.9e-25 86.8 0.0 9e-25 86.7 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EEA08096.1 - 0.00024 21.4 0.0 0.00034 20.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EEA08096.1 - 0.013 15.4 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 EEA08096.1 - 0.02 14.6 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_9 PF14595.6 EEA08096.1 - 0.041 13.7 0.0 0.047 13.5 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_2 PF13098.6 EEA08096.1 - 0.065 13.7 0.1 0.3 11.5 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain DUF3244 PF11589.8 EEA08098.1 - 0.002 18.2 5.2 0.002 18.2 5.2 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF3244) LPD14 PF18827.1 EEA08098.1 - 0.011 16.0 0.8 0.085 13.1 0.3 2.3 1 1 1 2 2 2 0 Large polyvalent protein-associated domain 14 DUF4392 PF14336.6 EEA08099.1 - 4.3e-20 72.3 0.0 1.3e-19 70.7 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4392) MSA-2c PF12238.8 EEA08099.1 - 0.038 14.0 0.5 0.22 11.5 0.2 2.1 2 0 0 2 2 2 0 Merozoite surface antigen 2c Pkinase PF00069.25 EEA08100.1 - 3e-36 125.1 2.8 3e-36 125.1 2.8 2.7 2 2 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08100.1 - 3.2e-16 59.4 0.0 8.1e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3823_C PF18003.1 EEA08101.1 - 0.026 15.2 0.5 0.026 15.2 0.5 5.1 7 1 0 7 7 7 0 Domain of unknown function (DUF3823_C) SNF2_N PF00176.23 EEA08102.1 - 4.3e-59 200.0 0.0 4.3e-59 200.0 0.0 3.0 2 1 1 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA08102.1 - 6.1e-21 74.9 0.0 3.7e-20 72.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EEA08102.1 - 1.7e-15 56.8 0.0 4.6e-15 55.5 0.0 1.8 1 0 0 1 1 1 1 Bromodomain Chromo PF00385.24 EEA08102.1 - 9.1e-12 44.7 0.3 2.3e-05 24.2 0.1 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.29 EEA08104.1 - 3e-35 121.6 0.0 5.1e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08104.1 - 6.5e-24 84.4 1.2 1.6e-22 79.9 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08104.1 - 1e-08 35.4 0.0 2.5e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EEA08104.1 - 0.0056 16.5 2.0 0.093 12.5 0.0 3.3 3 1 1 4 4 4 1 AAA domain UTP25 PF06862.12 EEA08104.1 - 0.037 12.8 1.6 4.3 6.0 0.1 2.3 1 1 1 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 RPAP1_C PF08620.10 EEA08105.1 - 1.2e-23 83.0 0.0 3.5e-23 81.5 0.0 1.9 1 0 0 1 1 1 1 RPAP1-like, C-terminal HEAT PF02985.22 EEA08105.1 - 0.026 14.8 0.1 0.11 12.9 0.1 2.1 1 0 0 1 1 1 0 HEAT repeat Rep_fac-A_3 PF08661.11 EEA08106.1 - 7.2e-16 58.4 0.0 8.3e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF150_C PF17384.2 EEA08106.1 - 0.024 14.7 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain RNA_ligase PF09414.10 EEA08107.1 - 9.7e-08 32.5 0.1 2e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 RNA ligase RNA_lig_T4_1 PF09511.10 EEA08107.1 - 0.00062 19.7 3.3 0.005 16.7 3.3 2.2 1 1 0 1 1 1 1 RNA ligase AAA_16 PF13191.6 EEA08107.1 - 0.057 13.8 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EEA08107.1 - 0.065 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain HSP70 PF00012.20 EEA08108.1 - 4.3e-263 874.0 8.5 4.9e-263 873.8 8.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA08108.1 - 1.2e-14 53.9 3.0 1e-12 47.6 0.7 2.5 1 1 1 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EEA08108.1 - 0.00067 19.4 0.0 0.0025 17.6 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EEA08108.1 - 0.0024 18.2 2.3 3.1 8.3 0.1 3.4 3 2 0 3 3 3 2 Cell division protein FtsA VSG_B PF13206.6 EEA08108.1 - 0.017 14.4 0.1 0.03 13.6 0.1 1.4 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF3664 PF12406.8 EEA08108.1 - 0.11 13.1 0.1 0.26 11.9 0.1 1.6 1 0 0 1 1 1 0 Surface protein DUF2096 PF09869.9 EEA08108.1 - 0.16 12.0 1.2 0.28 11.3 0.5 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) Cu_amine_oxid PF01179.20 EEA08109.1 - 3.8e-68 230.3 0.3 5.6e-68 229.7 0.3 1.3 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain MAM PF00629.23 EEA08109.1 - 2.9e-16 59.8 0.0 1.2e-15 57.7 0.0 2.1 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu DWNN PF08783.11 EEA08111.1 - 1.3e-14 54.2 0.2 3.3e-14 52.9 0.2 1.8 1 0 0 1 1 1 1 DWNN domain zf-RING_2 PF13639.6 EEA08111.1 - 0.0061 16.9 10.5 0.012 15.9 10.5 1.5 1 0 0 1 1 1 1 Ring finger domain Baculo_IE-1 PF05290.11 EEA08111.1 - 0.066 13.2 2.9 0.17 11.8 2.9 1.7 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_3 PF13920.6 EEA08111.1 - 0.071 13.0 11.4 0.12 12.2 11.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1115 PF06544.12 EEA08111.1 - 0.13 12.4 0.1 1.6 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) zf-RING_UBOX PF13445.6 EEA08111.1 - 0.17 12.0 5.6 0.47 10.5 4.5 2.3 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA08111.1 - 0.26 11.2 10.0 0.66 9.9 10.0 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EEA08111.1 - 0.58 10.1 11.1 1.2 9.0 11.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EEA08111.1 - 0.64 10.2 12.7 0.85 9.8 10.3 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EEA08111.1 - 3.1 7.7 11.0 6.2 6.7 11.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PCNA_N PF00705.18 EEA08112.1 - 4.3e-36 123.4 4.4 4.3e-36 123.4 4.4 1.5 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EEA08112.1 - 5.3e-34 117.2 0.1 9.7e-30 103.4 0.0 2.3 2 1 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 EEA08112.1 - 6.4e-10 38.5 1.2 6.1e-09 35.3 0.4 2.0 1 1 1 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 EEA08112.1 - 2.1e-06 27.4 0.3 5.9e-06 25.9 0.3 2.0 1 1 0 1 1 1 1 Rad9 DNA_pol3_beta_2 PF02767.16 EEA08112.1 - 0.00076 19.7 0.0 0.057 13.6 0.0 2.7 1 1 1 2 2 2 1 DNA polymerase III beta subunit, central domain Hus1 PF04005.12 EEA08112.1 - 0.001 18.3 0.2 0.0034 16.6 0.2 2.0 1 1 0 1 1 1 1 Hus1-like protein eIF-5a PF01287.20 EEA08112.1 - 0.065 13.3 0.1 0.18 11.9 0.1 1.7 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold WYL PF13280.6 EEA08112.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 WYL domain RRM_1 PF00076.22 EEA08114.1 - 4.4e-12 45.7 0.6 1.1e-10 41.1 0.1 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA08114.1 - 0.00045 20.3 0.1 0.042 14.0 0.0 2.7 2 1 0 2 2 2 1 RNA recognition motif PHM7_cyt PF14703.6 EEA08114.1 - 0.034 14.4 0.0 3.4 7.9 0.0 3.2 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Na_Ca_ex PF01699.24 EEA08116.1 - 1.5e-27 96.4 49.9 2.6e-18 66.4 15.7 3.1 3 0 0 3 3 3 2 Sodium/calcium exchanger protein zf-C2HC5 PF06221.13 EEA08117.1 - 5.8e-08 32.6 6.6 8.6e-08 32.1 6.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Rubella_E2 PF05749.11 EEA08117.1 - 0.04 13.4 0.2 0.055 12.9 0.2 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Peptidase_M18 PF02127.15 EEA08119.1 - 1.5e-127 426.0 0.0 1.8e-127 425.8 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EEA08119.1 - 5.9e-08 32.1 0.0 2.6e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase DUF2207 PF09972.9 EEA08120.1 - 8.2 5.1 10.4 1.5 7.5 1.8 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) BLM10_N PF16547.5 EEA08121.1 - 0.015 15.5 0.3 0.1 12.9 0.3 2.5 1 1 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal Ubiquitin_5 PF18037.1 EEA08121.1 - 1.8 8.9 0.0 1.8 8.9 0.0 3.9 4 1 1 5 5 5 0 Ubiquitin-like domain DUF773 PF05600.12 EEA08123.1 - 1.9e-22 79.7 15.4 5.3e-20 71.6 8.0 2.1 2 0 0 2 2 2 2 CDK5 regulatory subunit-associated protein 3 Seryl_tRNA_N PF02403.22 EEA08123.1 - 0.26 11.5 3.3 0.31 11.3 0.3 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BolA PF01722.18 EEA08124.1 - 7.7e-18 64.5 0.0 2.1e-17 63.2 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein CK_II_beta PF01214.18 EEA08125.1 - 6.8e-69 231.3 0.1 1.1e-68 230.7 0.1 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit DUF4205 PF13898.6 EEA08126.1 - 7.7e-49 166.5 0.1 2.7e-48 164.7 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4205) DEAD PF00270.29 EEA08127.1 - 1.2e-46 158.6 0.0 6.5e-46 156.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08127.1 - 4.3e-29 101.1 1.7 3.8e-28 98.0 0.6 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08127.1 - 0.029 14.4 0.0 0.12 12.4 0.0 2.0 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF4898 PF16239.5 EEA08129.1 - 0.027 14.4 0.5 0.06 13.3 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4898) Radical_SAM_C PF16199.5 EEA08129.1 - 0.19 11.8 0.0 5.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Radical_SAM C-terminal domain Ctf8 PF09696.10 EEA08130.1 - 7.3e-09 36.1 0.0 2.8e-07 30.9 0.0 2.2 1 1 0 1 1 1 1 Ctf8 Neurexophilin PF06312.12 EEA08130.1 - 0.11 12.0 0.2 0.21 11.0 0.1 1.5 1 1 1 2 2 2 0 Neurexophilin zinc_ribbon_9 PF14369.6 EEA08131.1 - 0.027 14.7 0.2 0.027 14.7 0.2 2.8 2 1 0 2 2 2 0 zinc-ribbon E1-E2_ATPase PF00122.20 EEA08132.1 - 2.2e-34 118.6 2.5 2.3e-33 115.2 0.5 2.9 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EEA08132.1 - 1.2e-19 71.4 0.0 1.9e-13 51.2 0.0 3.0 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase HMA PF00403.26 EEA08132.1 - 1e-07 32.3 0.2 3.5e-07 30.6 0.2 2.1 1 0 0 1 1 1 1 Heavy-metal-associated domain NPV_P10 PF05531.12 EEA08133.1 - 0.042 14.3 2.0 0.11 12.9 0.2 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EEA08133.1 - 0.055 13.5 1.3 0.24 11.4 0.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) ARGLU PF15346.6 EEA08133.1 - 0.095 12.6 33.2 0.025 14.4 27.8 2.1 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 G-patch PF01585.23 EEA08134.1 - 6.6e-16 57.9 1.3 1.3e-15 57.0 1.3 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EEA08134.1 - 3.3e-08 33.5 0.1 3.3e-08 33.5 0.1 2.3 2 1 0 2 2 2 1 G-patch domain Pkinase PF00069.25 EEA08135.1 - 5.1e-41 140.8 0.0 1e-40 139.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08135.1 - 1.1e-20 74.0 0.0 2.3e-20 73.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase CAML PF14963.6 EEA08136.1 - 0.014 15.5 0.6 0.021 14.9 0.1 1.4 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand SPX PF03105.19 EEA08136.1 - 0.076 12.9 1.1 0.092 12.6 1.1 1.1 1 0 0 1 1 1 0 SPX domain EF-hand_7 PF13499.6 EEA08137.1 - 1.1e-05 25.8 0.8 0.6 10.6 0.1 4.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EEA08137.1 - 1.3e-05 24.4 9.5 0.018 14.6 0.8 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EEA08137.1 - 1.4e-05 24.8 7.3 0.014 15.2 1.8 4.0 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 EEA08137.1 - 0.00093 19.0 9.1 0.44 10.6 0.8 4.7 5 0 0 5 5 5 2 EF-hand domain RNA_pol_Rpa2_4 PF06883.12 EEA08137.1 - 0.012 15.6 0.0 0.04 13.9 0.0 1.9 1 0 0 1 1 1 0 RNA polymerase I, Rpa2 specific domain EF-hand_5 PF13202.6 EEA08137.1 - 0.019 14.5 5.0 0.048 13.2 0.3 2.9 2 0 0 2 2 2 0 EF hand GP17 PF17420.2 EEA08138.1 - 3.4 7.9 5.7 12 6.1 2.7 2.5 2 1 0 2 2 2 0 Superinfection exclusion gene product 17 AAA_5 PF07728.14 EEA08139.1 - 4.2e-89 295.7 0.4 2e-21 76.4 0.0 9.7 8 1 0 8 8 8 8 AAA domain (dynein-related subfamily) AAA_lid_5 PF17865.1 EEA08139.1 - 4.2e-25 87.9 0.0 3.8e-24 84.8 0.0 2.9 1 0 0 1 1 1 1 Midasin AAA lid domain Dynein_heavy PF03028.15 EEA08139.1 - 2.4e-24 85.7 0.2 0.0013 18.8 0.0 7.7 7 0 0 7 7 6 5 Dynein heavy chain region D6 P-loop domain AAA_3 PF07726.11 EEA08139.1 - 1e-19 70.7 0.0 0.00014 21.7 0.0 5.9 6 0 0 6 6 5 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EEA08139.1 - 2.1e-18 66.5 0.3 6.9e-05 22.4 0.0 4.7 4 0 0 4 4 4 4 P-loop containing dynein motor region AAA_lid_7 PF17867.1 EEA08139.1 - 3e-17 62.7 1.1 9.3e-12 45.1 0.1 4.7 4 0 0 4 4 4 2 Midasin AAA lid domain AAA PF00004.29 EEA08139.1 - 6.9e-16 58.9 0.3 0.0012 19.3 0.0 5.8 6 0 0 6 6 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA08139.1 - 3.4e-15 56.9 0.0 0.0014 19.0 0.0 5.3 4 0 0 4 4 4 3 AAA ATPase domain AAA_6 PF12774.7 EEA08139.1 - 1.6e-12 47.1 0.1 0.039 12.9 0.0 7.1 6 1 0 6 6 6 2 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EEA08139.1 - 5.4e-11 42.9 0.0 0.01 16.1 0.0 5.1 4 0 0 4 4 4 2 AAA domain Sigma54_activat PF00158.26 EEA08139.1 - 1.9e-10 40.7 0.0 0.24 11.1 0.0 5.4 6 0 0 6 6 5 3 Sigma-54 interaction domain AAA_18 PF13238.6 EEA08139.1 - 2.3e-09 37.9 8.3 0.014 16.0 0.0 6.7 5 0 0 5 5 4 3 AAA domain T2SSE PF00437.20 EEA08139.1 - 8.5e-09 34.9 1.2 0.24 10.4 0.0 4.4 4 0 0 4 4 4 3 Type II/IV secretion system protein TsaE PF02367.17 EEA08139.1 - 1.4e-08 34.7 0.1 0.71 9.9 0.0 4.9 4 0 0 4 4 4 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EEA08139.1 - 1.5e-08 34.7 25.9 0.099 12.7 0.0 9.8 9 1 1 10 10 8 3 AAA domain Mg_chelatase PF01078.21 EEA08139.1 - 3.9e-08 32.9 0.0 1.4 8.2 0.0 5.9 6 0 0 6 6 6 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EEA08139.1 - 5.8e-08 33.0 0.0 0.055 13.6 0.0 4.8 5 0 0 5 5 4 2 AAA domain TniB PF05621.11 EEA08139.1 - 4.7e-07 29.4 0.0 0.071 12.5 0.0 3.7 3 0 0 3 3 3 2 Bacterial TniB protein ABC_tran PF00005.27 EEA08139.1 - 1.4e-06 28.9 9.4 0.034 14.6 0.0 6.1 5 0 0 5 5 4 2 ABC transporter AAA_19 PF13245.6 EEA08139.1 - 2.9e-06 27.7 0.1 0.45 10.8 0.0 4.3 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.6 EEA08139.1 - 8.3e-06 25.7 0.0 1.2 8.9 0.0 5.2 6 0 0 6 6 5 1 AAA domain PduV-EutP PF10662.9 EEA08139.1 - 2.1e-05 24.3 0.0 0.26 11.0 0.0 3.9 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation VWA_2 PF13519.6 EEA08139.1 - 2.6e-05 24.8 0.0 0.00015 22.4 0.0 2.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Sigma54_activ_2 PF14532.6 EEA08139.1 - 3.3e-05 24.0 0.1 1.4 9.0 0.0 4.3 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_29 PF13555.6 EEA08139.1 - 7.5e-05 22.4 0.0 0.21 11.3 0.0 3.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain NACHT PF05729.12 EEA08139.1 - 0.0001 22.3 0.2 2.2 8.2 0.0 4.0 3 0 0 3 3 3 2 NACHT domain AAA_28 PF13521.6 EEA08139.1 - 0.00013 22.2 1.7 4.1 7.6 0.0 4.0 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 EEA08139.1 - 0.00017 22.0 4.6 0.39 11.1 0.0 6.6 6 0 0 6 6 5 1 RNA helicase AAA_25 PF13481.6 EEA08139.1 - 0.0015 18.2 0.0 1.3 8.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EEA08139.1 - 0.0018 17.6 0.0 2 7.7 0.0 3.5 2 0 0 2 2 2 1 KaiC RsgA_GTPase PF03193.16 EEA08139.1 - 0.0018 18.2 0.0 2.1 8.2 0.0 3.9 3 0 0 3 3 3 1 RsgA GTPase Roc PF08477.13 EEA08139.1 - 0.002 18.4 0.1 6.1 7.1 0.0 4.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 EEA08139.1 - 0.0022 17.6 0.2 4.2 6.9 0.0 3.3 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain IstB_IS21 PF01695.17 EEA08139.1 - 0.0072 16.1 0.1 7.8 6.2 0.0 3.3 3 0 0 3 3 2 0 IstB-like ATP binding protein PhoH PF02562.16 EEA08139.1 - 0.026 14.0 0.0 5.1 6.5 0.0 2.8 2 0 0 2 2 2 0 PhoH-like protein AAA_17 PF13207.6 EEA08139.1 - 0.028 14.9 0.0 0.31 11.5 0.0 2.9 2 0 0 2 2 1 0 AAA domain RuvB_N PF05496.12 EEA08139.1 - 0.042 13.6 8.8 2.1 8.1 0.0 5.3 6 0 0 6 6 5 0 Holliday junction DNA helicase RuvB P-loop domain DEAD PF00270.29 EEA08139.1 - 0.087 12.6 0.1 30 4.3 0.0 4.1 4 0 0 4 4 4 0 DEAD/DEAH box helicase CPT PF07931.12 EEA08139.1 - 0.2 11.5 0.0 24 4.7 0.0 3.7 4 0 0 4 4 2 0 Chloramphenicol phosphotransferase-like protein tRNA_int_endo PF01974.17 EEA08140.1 - 1.3e-18 66.8 0.0 2.6e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain R3H PF01424.22 EEA08141.1 - 0.12 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 R3H domain TPR_2 PF07719.17 EEA08142.1 - 2e-05 24.3 1.3 0.93 9.8 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA08142.1 - 0.00055 19.6 5.7 0.8 9.6 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat DDE_Tnp_IS66 PF03050.14 EEA08142.1 - 0.0055 16.2 0.1 0.0087 15.6 0.1 1.3 1 0 0 1 1 1 1 Transposase IS66 family TPR_11 PF13414.6 EEA08142.1 - 0.02 14.6 2.4 0.4 10.4 0.3 2.9 3 0 0 3 3 3 0 TPR repeat RNR_Alpha PF17975.1 EEA08142.1 - 0.057 13.9 0.8 0.12 12.9 0.1 1.7 2 0 0 2 2 2 0 Ribonucleotide reductase alpha domain MIT PF04212.18 EEA08142.1 - 3.8 7.6 6.8 0.89 9.7 0.7 2.6 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Thymidylate_kin PF02223.17 EEA08145.1 - 2.8e-41 141.2 0.0 3.2e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase KTI12 PF08433.10 EEA08145.1 - 0.0021 17.6 0.0 0.0053 16.2 0.0 1.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.6 EEA08145.1 - 0.0039 17.5 0.0 0.0055 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EEA08145.1 - 0.23 11.0 0.0 0.51 9.9 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain zf-DNL PF05180.12 EEA08148.1 - 8e-25 86.6 1.5 1.4e-24 85.8 1.5 1.4 1 0 0 1 1 1 1 DNL zinc finger FYVE_2 PF02318.16 EEA08149.1 - 0.051 13.8 1.2 0.17 12.1 1.2 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger C1_4 PF07975.12 EEA08149.1 - 9.3 6.6 8.3 3.4 8.0 3.5 2.6 3 0 0 3 3 3 0 TFIIH C1-like domain DUF1031 PF06275.11 EEA08150.1 - 0.064 13.5 1.0 1.9 8.8 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) Ntox47 PF15540.6 EEA08150.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 47 TRAM_LAG1_CLN8 PF03798.16 EEA08151.1 - 5.2e-24 85.1 16.5 8.4e-24 84.4 16.5 1.3 1 0 0 1 1 1 1 TLC domain DUF679 PF05078.12 EEA08151.1 - 0.063 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF679) Sec1 PF00995.23 EEA08152.1 - 1.9e-105 354.3 12.4 2.2e-105 354.1 12.4 1.0 1 0 0 1 1 1 1 Sec1 family Cg6151-P PF10233.9 EEA08152.1 - 0.19 12.1 0.1 0.43 10.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein CG6151-P RTX_C PF08339.10 EEA08152.1 - 0.96 9.5 10.4 0.52 10.4 1.4 4.1 4 2 0 4 4 4 0 RTX C-terminal domain LSM PF01423.22 EEA08153.1 - 1.8e-09 37.1 0.0 2.9e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EEA08153.1 - 0.037 14.2 0.0 0.057 13.6 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF1299 PF06975.11 EEA08153.1 - 0.085 13.0 0.4 4.1 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1299) PUB PF09409.10 EEA08153.1 - 0.15 12.0 0.2 0.3 11.1 0.0 1.6 2 0 0 2 2 2 0 PUB domain Ribosomal_S17e PF00833.18 EEA08154.1 - 4.2e-55 184.9 0.5 4.9e-55 184.7 0.5 1.0 1 0 0 1 1 1 1 Ribosomal S17 SPATA24 PF15175.6 EEA08154.1 - 0.048 13.6 0.2 0.087 12.7 0.2 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 Ank_2 PF12796.7 EEA08155.1 - 3.2e-25 88.5 4.1 7.5e-09 36.1 0.3 4.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EEA08155.1 - 3.9e-22 78.0 5.8 1.6e-05 25.0 0.0 5.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EEA08155.1 - 6.6e-20 70.6 5.2 0.026 15.0 0.1 6.8 6 1 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EEA08155.1 - 3.5e-19 68.9 5.4 4.4e-05 23.9 0.1 5.3 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA08155.1 - 4.1e-18 63.6 4.8 0.0058 17.0 0.1 6.8 6 0 0 6 6 6 4 Ankyrin repeat PhoLip_ATPase_C PF16212.5 EEA08155.1 - 0.02 14.7 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal GWT1 PF06423.12 EEA08155.1 - 0.035 14.2 0.1 0.077 13.1 0.1 1.7 1 0 0 1 1 1 0 GWT1 Ribosomal_L7Ae PF01248.26 EEA08156.1 - 2e-23 81.9 0.3 2.6e-23 81.6 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.12 EEA08156.1 - 0.0088 16.3 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Hexapep PF00132.24 EEA08157.1 - 1.3e-08 34.3 18.9 4.2e-06 26.3 5.2 4.4 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EEA08157.1 - 0.00091 18.3 0.8 0.0014 17.7 0.8 1.3 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 EEA08157.1 - 0.0011 18.7 20.3 0.0021 17.7 6.0 4.2 2 2 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4602 PF15375.6 EEA08158.1 - 7.9e-07 29.5 14.9 3.9e-06 27.2 14.7 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4602) Methyltransf_25 PF13649.6 EEA08159.1 - 4.2e-08 33.8 0.3 4.2e-07 30.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA08159.1 - 1.2e-07 31.7 0.1 3.7e-07 30.1 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA08159.1 - 1.2e-07 31.5 0.4 1.2e-07 31.5 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EEA08159.1 - 8.6e-06 25.8 0.6 3.6e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EEA08159.1 - 0.00057 19.5 0.2 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EEA08159.1 - 0.0026 17.6 0.0 0.0051 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA08159.1 - 0.0027 18.3 0.2 0.036 14.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain zf-C2H2_2 PF12756.7 EEA08159.1 - 0.01 16.2 0.9 0.036 14.4 0.9 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Methyltransf_12 PF08242.12 EEA08159.1 - 0.031 15.0 0.1 0.12 13.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain MIS13 PF08202.11 EEA08159.1 - 0.19 11.0 6.4 0.32 10.2 6.4 1.4 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Prefoldin PF02996.17 EEA08159.1 - 0.24 11.3 4.2 0.48 10.4 2.9 2.1 2 0 0 2 2 2 0 Prefoldin subunit Vasculin PF15337.6 EEA08159.1 - 0.27 12.1 2.5 1 10.2 2.5 2.0 1 0 0 1 1 1 0 Vascular protein family Vasculin-like 1 zf-HIT PF04438.16 EEA08160.1 - 3.7e-06 26.7 12.9 6.1e-06 26.0 12.9 1.4 1 0 0 1 1 1 1 HIT zinc finger ArfGap PF01412.18 EEA08160.1 - 0.011 15.7 2.6 0.022 14.8 2.6 1.6 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf HeH PF12949.7 EEA08160.1 - 0.026 14.2 0.1 0.067 12.9 0.1 1.8 1 0 0 1 1 1 0 HeH/LEM domain Snf7 PF03357.21 EEA08161.1 - 5.8e-21 74.8 28.0 7.5e-21 74.5 28.0 1.1 1 0 0 1 1 1 1 Snf7 IclR PF01614.18 EEA08161.1 - 0.71 9.7 6.9 0.099 12.5 0.6 2.5 1 1 1 2 2 2 0 Bacterial transcriptional regulator P16-Arc PF04699.14 EEA08161.1 - 4.4 7.8 12.2 0.59 10.6 5.6 2.2 1 1 1 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) GP3_package PF16677.5 EEA08162.1 - 0.16 12.1 0.8 3.6 7.8 0.1 2.9 3 0 0 3 3 3 0 DNA-packaging protein gp3 SNARE_assoc PF09335.11 EEA08164.1 - 5.6e-06 26.8 0.4 5.6e-06 26.8 0.4 3.0 3 1 0 3 3 3 1 SNARE associated Golgi protein FoP_duplication PF13865.6 EEA08165.1 - 2.2e-17 63.4 6.1 2.2e-17 63.4 6.1 2.9 1 1 1 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 BSD PF03909.17 EEA08166.1 - 8.6e-14 51.3 0.1 3.4e-13 49.4 0.1 2.0 1 0 0 1 1 1 1 BSD domain DUF1959 PF09218.10 EEA08166.1 - 0.2 11.8 0.0 0.2 11.8 0.0 3.5 5 0 0 5 5 5 0 Domain of unknown function (DUF1959) DHHC PF01529.20 EEA08167.1 - 5.9e-28 97.6 16.7 5.9e-28 97.6 16.7 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase TRAP-gamma PF07074.12 EEA08167.1 - 0.55 9.8 0.0 0.55 9.8 0.0 2.9 2 2 1 3 3 3 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Spo7 PF03907.13 EEA08167.1 - 1.3 8.4 3.4 3 7.3 3.4 1.5 1 0 0 1 1 1 0 Spo7-like protein DUF1240 PF06836.12 EEA08167.1 - 9.8 6.8 9.9 4.8 7.8 3.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) ACPS PF01648.20 EEA08168.1 - 2.4e-10 40.5 0.1 6.1e-10 39.2 0.1 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily FGF PF00167.18 EEA08169.1 - 0.17 12.0 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Fibroblast growth factor DEAD PF00270.29 EEA08170.1 - 1.7e-29 102.8 0.0 5.8e-29 101.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08170.1 - 3e-22 79.1 0.1 8.5e-22 77.6 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08170.1 - 1.7e-05 24.9 0.0 4.3e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit BNR_assoc_N PF14873.6 EEA08170.1 - 0.059 13.1 0.1 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of BNR-repeat neuraminidase Methyltransf_25 PF13649.6 EEA08171.1 - 5.4e-09 36.6 0.0 1.2e-08 35.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EEA08171.1 - 1.2e-08 34.7 0.0 1.7e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EEA08171.1 - 3.2e-08 33.5 0.2 7.3e-08 32.3 0.2 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EEA08171.1 - 1.5e-06 28.8 0.0 3e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EEA08171.1 - 3.1e-05 23.9 0.0 4.4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EEA08171.1 - 0.0001 22.3 0.5 0.00071 19.5 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 EEA08171.1 - 0.00034 19.7 0.0 0.00046 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 EEA08171.1 - 0.0007 19.2 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EEA08171.1 - 0.00071 19.4 0.1 0.0011 18.7 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase DOT1 PF08123.13 EEA08171.1 - 0.0045 16.5 0.0 0.0089 15.6 0.0 1.5 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 EEA08171.1 - 0.025 15.3 0.0 0.056 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EEA08171.1 - 0.071 12.7 0.0 0.15 11.7 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical protein 95 PCMT PF01135.19 EEA08171.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CPSF_A PF03178.15 EEA08172.1 - 6.9e-20 71.6 0.0 1.4e-15 57.4 0.0 2.9 2 0 0 2 2 2 2 CPSF A subunit region ATP-synt_C PF00137.21 EEA08175.1 - 5.7e-29 100.2 17.7 5.4e-16 58.7 6.7 2.1 2 0 0 2 2 2 2 ATP synthase subunit C RINGv PF12906.7 EEA08176.1 - 5.1e-13 48.9 7.2 9.3e-13 48.1 7.2 1.5 1 0 0 1 1 1 1 RING-variant domain FHA PF00498.26 EEA08176.1 - 4e-12 46.3 0.6 4e-12 46.3 0.6 2.7 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EEA08176.1 - 2.7e-08 34.0 0.1 2.2e-07 31.1 0.1 2.2 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain FANCL_C PF11793.8 EEA08176.1 - 0.051 13.8 4.1 0.095 12.9 4.1 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_2 PF13639.6 EEA08176.1 - 0.11 12.8 9.9 0.42 11.0 10.2 1.8 1 1 1 2 2 2 0 Ring finger domain NIF PF03031.18 EEA08177.1 - 6e-15 55.3 2.2 1.9e-10 40.7 0.0 3.3 3 0 0 3 3 3 2 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 EEA08177.1 - 0.0034 17.3 0.1 0.0072 16.2 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EEA08177.1 - 0.008 16.5 0.0 0.045 14.1 0.0 2.3 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain ESCRT-II PF05871.12 EEA08177.1 - 0.31 11.3 2.9 7.6 6.8 0.3 2.4 2 0 0 2 2 2 0 ESCRT-II complex subunit Raptor_N PF14538.6 EEA08178.1 - 0.031 14.2 0.3 0.036 14.0 0.3 1.2 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain DUF3900 PF13039.6 EEA08178.1 - 0.047 13.6 0.3 0.064 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3900) Med27 PF11571.8 EEA08178.1 - 0.1 13.0 6.7 0.75 10.2 0.9 2.2 1 1 1 2 2 2 0 Mediator complex subunit 27 TFIIF_beta PF02270.15 EEA08178.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain SIR2 PF02146.17 EEA08178.1 - 0.26 11.2 2.1 0.36 10.7 2.1 1.4 1 1 0 1 1 1 0 Sir2 family TFIID-31kDa PF02291.15 EEA08179.1 - 2.8e-12 46.8 0.0 3.2e-12 46.6 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF1931 PF09123.11 EEA08179.1 - 0.071 13.2 0.0 0.084 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) Kazal_1 PF00050.21 EEA08180.1 - 1.1e-07 31.7 3.5 2.1e-07 30.9 3.5 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EEA08180.1 - 1.2e-05 25.4 3.2 2.1e-05 24.5 3.2 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Enterotoxin_a PF01375.17 EEA08180.1 - 0.027 14.1 1.6 0.044 13.4 1.6 1.2 1 0 0 1 1 1 0 Heat-labile enterotoxin alpha chain Myb_DNA-binding PF00249.31 EEA08181.1 - 1.4e-05 25.2 0.1 5e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Sad1_UNC PF07738.13 EEA08182.1 - 5.7e-12 45.8 0.4 2.5e-10 40.5 0.3 3.1 2 1 0 2 2 2 1 Sad1 / UNC-like C-terminal Fcf1 PF04900.12 EEA08184.1 - 1.6e-22 79.8 2.7 8.3e-15 55.0 0.0 3.0 2 1 1 3 3 3 2 Fcf1 PIN_9 PF18477.1 EEA08184.1 - 3.6e-07 30.5 0.0 0.0027 18.0 0.0 2.4 1 1 1 2 2 2 2 PIN like domain DUF5492 PF17596.2 EEA08185.1 - 0.13 12.6 0.4 0.13 12.6 0.4 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5492) DUF4083 PF13314.6 EEA08185.1 - 0.18 11.7 0.2 0.18 11.7 0.2 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4083) DUF2207 PF09972.9 EEA08185.1 - 6.9 5.3 12.7 2.8 6.6 9.3 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Clat_adaptor_s PF01217.20 EEA08187.1 - 2.2e-40 137.9 6.6 2.5e-40 137.7 6.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HOCHOB PF17943.1 EEA08187.1 - 0.17 12.6 1.7 1.9 9.2 1.6 2.4 1 1 0 1 1 1 0 Homeobox-cysteine loop-homeobox UCH_1 PF13423.6 EEA08188.1 - 1.7e-25 90.3 12.9 2.9e-25 89.5 12.9 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EEA08188.1 - 1.2e-10 42.1 0.0 1e-09 39.2 0.0 2.2 2 0 0 2 2 2 1 Exonuclease WD40_like PF17005.5 EEA08189.1 - 1.9e-05 24.2 3.6 7e-05 22.3 3.7 1.9 1 1 0 1 1 1 1 WD40-like domain WD40 PF00400.32 EEA08189.1 - 0.001 19.8 0.9 1.7 9.7 0.0 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat Hira PF07569.11 EEA08189.1 - 0.022 14.5 0.7 0.082 12.6 0.2 2.1 2 1 0 2 2 2 0 TUP1-like enhancer of split Pyrid_ox_like PF16242.5 EEA08190.1 - 0.003 17.2 0.1 0.0065 16.1 0.1 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like WBP-1 PF11669.8 EEA08190.1 - 0.095 13.3 0.2 0.17 12.5 0.2 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 NADH_4Fe-4S PF10589.9 EEA08191.1 - 0.42 10.7 1.3 19 5.4 0.2 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Exostosin PF03016.15 EEA08192.1 - 3.7e-05 23.1 0.0 5.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DnaJ PF00226.31 EEA08193.1 - 1.8e-20 72.8 0.9 8.1e-20 70.7 0.9 2.3 1 0 0 1 1 1 1 DnaJ domain Glyco_transf_20 PF00982.21 EEA08194.1 - 4.6e-92 309.2 0.5 1.1e-68 232.0 0.1 2.4 2 1 0 2 2 2 2 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EEA08194.1 - 7.3e-47 159.5 0.0 9.8e-46 155.8 0.0 2.3 1 1 0 1 1 1 1 Trehalose-phosphatase Glycos_transf_1 PF00534.20 EEA08194.1 - 0.033 13.7 0.0 22 4.5 0.0 3.2 3 0 0 3 3 3 0 Glycosyl transferases group 1 Hydrolase_3 PF08282.12 EEA08194.1 - 0.26 11.0 7.8 0.077 12.7 0.3 3.2 1 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Helicase_C PF00271.31 EEA08195.1 - 5.5e-20 71.8 0.0 3.3e-19 69.2 0.0 2.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA08195.1 - 1.4e-15 57.5 0.0 2.1e-14 53.7 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA08195.1 - 1.5e-11 44.6 0.0 1.5e-11 44.6 0.0 3.5 4 1 1 5 5 5 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 EEA08195.1 - 0.015 15.5 0.5 0.21 11.7 0.5 2.8 1 1 0 1 1 1 0 Helicase C-terminal domain CfAFP PF05264.11 EEA08195.1 - 0.054 13.5 0.0 0.25 11.4 0.0 2.1 1 0 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) eIF3_p135 PF12807.7 EEA08196.1 - 0.00013 22.1 0.1 0.00013 22.1 0.1 3.8 4 0 0 4 4 4 1 Translation initiation factor eIF3 subunit 135 CYYR1 PF10873.8 EEA08196.1 - 0.0081 16.6 0.3 0.017 15.6 0.3 1.4 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 ANAPC3 PF12895.7 EEA08196.1 - 0.11 12.8 4.1 1.6 9.0 0.1 3.9 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Kelch_5 PF13854.6 EEA08197.1 - 3.2e-18 65.3 9.5 1e-05 25.4 0.2 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EEA08197.1 - 5.7e-17 61.5 8.1 0.00085 19.3 0.0 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EEA08197.1 - 9.6e-08 31.5 17.5 0.45 10.1 0.0 6.8 7 1 0 7 7 7 3 Kelch motif Kelch_2 PF07646.15 EEA08197.1 - 2e-06 27.5 11.4 0.96 9.5 0.0 6.5 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 EEA08197.1 - 1.3e-05 25.3 12.8 0.097 13.0 0.0 6.8 5 1 1 6 6 6 1 Kelch motif CathepsinC_exc PF08773.11 EEA08197.1 - 0.015 15.6 2.1 0.068 13.5 2.1 2.1 1 0 0 1 1 1 0 Cathepsin C exclusion domain RNase_J_C PF17770.1 EEA08197.1 - 0.65 11.1 4.4 14 6.8 0.5 3.9 4 0 0 4 4 4 0 Ribonuclease J C-terminal domain Gtr1_RagA PF04670.12 EEA08198.1 - 6.2e-43 146.8 2.1 6.2e-43 146.8 2.1 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA08198.1 - 6.9e-08 32.6 0.1 1.8e-07 31.2 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EEA08198.1 - 1.6e-07 31.0 1.1 1.7e-07 30.9 0.1 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EEA08198.1 - 4.1e-06 26.4 0.0 7e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA08198.1 - 0.02 15.1 0.0 0.042 14.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EEA08198.1 - 0.059 13.4 4.6 0.81 9.7 4.6 2.7 1 1 0 1 1 1 0 Dynamin family Utp12 PF04003.12 EEA08199.1 - 5.4e-06 26.7 1.4 8.2e-06 26.1 1.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF4844 PF16133.5 EEA08199.1 - 0.43 11.1 7.7 0.19 12.3 3.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4844) PSI_PSAK PF01241.18 EEA08200.1 - 0.015 15.3 1.4 0.03 14.3 0.6 1.8 2 0 0 2 2 2 0 Photosystem I psaG / psaK CBM_20 PF00686.19 EEA08201.1 - 3.5e-23 81.3 1.2 5.3e-23 80.8 1.2 1.2 1 0 0 1 1 1 1 Starch binding domain SSXRD PF09514.10 EEA08201.1 - 6.4 6.5 9.1 0.51 10.0 2.1 2.4 1 1 1 2 2 2 0 SSXRD motif IMCp PF12314.8 EEA08202.1 - 2.8e-18 66.0 55.3 9.6e-17 61.1 25.1 3.7 1 1 3 4 4 4 4 Inner membrane complex protein Med3 PF11593.8 EEA08202.1 - 0.86 8.7 7.3 1.2 8.2 7.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF727 PF05303.12 EEA08203.1 - 0.0013 18.8 0.2 0.0016 18.5 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF727) DHHC PF01529.20 EEA08204.1 - 4.7e-31 107.7 9.7 4.7e-31 107.7 9.7 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF2207 PF09972.9 EEA08204.1 - 2.7 6.6 3.9 0.76 8.5 0.4 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Sedlin_N PF04628.13 EEA08207.1 - 1.2e-32 112.8 0.0 1.4e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EEA08207.1 - 5.2e-05 23.2 0.0 7.4e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 Sybindin-like family Tyrosinase PF00264.20 EEA08208.1 - 0.067 13.5 4.3 0.098 12.9 4.3 1.4 1 0 0 1 1 1 0 Common central domain of tyrosinase AP-5_subunit_s1 PF15001.6 EEA08210.1 - 0.0032 17.5 0.0 0.0036 17.3 0.0 1.1 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 ENOD40 PF08247.11 EEA08210.1 - 0.11 12.6 1.7 0.29 11.2 1.7 1.7 1 0 0 1 1 1 0 ENOD40 protein Pepsin-I3 PF06394.13 EEA08211.1 - 0.012 15.7 6.2 0.62 10.3 0.2 3.1 1 1 2 3 3 3 0 Pepsin inhibitor-3-like repeated domain RAC_head PF16717.5 EEA08211.1 - 0.026 15.5 4.6 0.039 14.9 4.3 1.5 1 1 0 1 1 1 0 Ribosome-associated complex head domain CRISPR_Cas2 PF09827.9 EEA08211.1 - 0.24 11.6 6.0 0.1 12.8 2.2 2.2 1 1 0 2 2 2 0 CRISPR associated protein Cas2 Fzo_mitofusin PF04799.13 EEA08211.1 - 0.48 10.0 8.0 0.17 11.4 3.4 2.0 1 1 1 2 2 2 0 fzo-like conserved region Pkinase PF00069.25 EEA08212.1 - 4.4e-60 203.3 0.1 5.6e-60 202.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08212.1 - 1.6e-41 142.3 0.1 3.8e-41 141.1 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA08212.1 - 2e-06 27.4 0.0 4.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA08212.1 - 1.7e-05 23.8 0.1 3.1e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EEA08212.1 - 0.011 14.7 0.3 0.018 14.0 0.3 1.5 1 1 0 1 1 1 0 Haspin like kinase domain RRM_1 PF00076.22 EEA08213.1 - 4.8e-18 64.7 0.7 2.9e-08 33.4 0.1 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA08213.1 - 0.00033 20.7 0.0 0.00089 19.3 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EEA08213.1 - 0.0049 16.8 0.0 0.55 10.3 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif EMP24_GP25L PF01105.24 EEA08214.1 - 6.3e-19 68.6 4.0 1.1e-18 67.8 4.0 1.4 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GH43_C PF16369.5 EEA08214.1 - 0.013 16.1 2.0 0.051 14.2 0.6 2.1 2 0 0 2 2 2 0 C-terminal lipocalin-like domain RNB PF00773.19 EEA08215.1 - 1.1e-82 278.0 2.4 1.1e-82 278.0 2.4 2.3 2 1 0 2 2 2 1 RNB domain Peptidase_S49 PF01343.18 EEA08217.1 - 0.04 13.9 0.1 0.089 12.7 0.1 1.6 2 0 0 2 2 2 0 Peptidase family S49 MIT_C PF16565.5 EEA08217.1 - 0.13 12.2 4.3 0.38 10.7 0.5 2.4 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT DUF1664 PF07889.12 EEA08217.1 - 0.59 10.2 10.2 2.5 8.2 0.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Bac_RepA_C PF18008.1 EEA08217.1 - 1.2 9.5 7.9 0.54 10.6 2.2 2.9 2 2 1 3 3 3 0 Replication initiator protein A C-terminal domain Pkinase PF00069.25 EEA08218.1 - 1e-53 182.4 0.4 1e-53 182.4 0.4 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08218.1 - 4.1e-28 98.4 0.1 3.1e-27 95.5 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Cas_Cas6 PF01881.16 EEA08218.1 - 0.011 16.3 1.8 0.011 16.3 1.8 2.8 3 1 1 4 4 4 0 CRISPR associated protein Cas6 APH PF01636.23 EEA08218.1 - 0.18 11.7 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family HEAT PF02985.22 EEA08219.1 - 0.0027 17.8 0.3 3.3 8.2 0.3 3.9 3 0 0 3 3 3 2 HEAT repeat PAC3 PF10178.9 EEA08219.1 - 0.04 14.1 0.1 0.21 11.8 0.0 2.2 2 0 0 2 2 2 0 Proteasome assembly chaperone 3 BRCA2 PF00634.18 EEA08220.1 - 1.4e-20 72.7 15.6 2.3e-06 27.1 0.7 4.5 4 0 0 4 4 4 3 BRCA2 repeat BRCA-2_OB1 PF09103.10 EEA08220.1 - 5.4e-12 45.7 0.6 2.1e-11 43.8 0.0 2.4 3 0 0 3 3 3 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Ribosomal_L33 PF00471.20 EEA08220.1 - 0.19 12.2 1.6 1.8 9.1 0.1 3.2 2 0 0 2 2 2 0 Ribosomal protein L33 PAP2 PF01569.21 EEA08221.1 - 0.03 14.1 15.1 0.034 13.9 10.0 2.6 2 1 0 2 2 2 0 PAP2 superfamily Phage_holin_2_3 PF16080.5 EEA08221.1 - 6.5 6.6 7.2 17 5.2 0.6 2.9 2 1 1 3 3 3 0 Bacteriophage holin family HP1 OST3_OST6 PF04756.13 EEA08223.1 - 1.9e-30 106.3 10.4 2.6e-30 105.8 10.4 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family CspB_prodomain PF18425.1 EEA08223.1 - 0.1 12.6 0.3 0.57 10.2 0.3 2.1 1 1 0 1 1 1 0 Csp protease B prodomain Myc_target_1 PF15179.6 EEA08223.1 - 0.26 11.2 1.1 0.43 10.5 1.1 1.4 1 0 0 1 1 1 0 Myc target protein 1 SCIMP PF15050.6 EEA08223.1 - 1.2 9.6 3.3 1.3 9.5 0.2 2.5 1 1 1 2 2 2 0 SCIMP protein DUF4131 PF13567.6 EEA08223.1 - 1.9 8.1 10.6 0.35 10.5 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) CENP-T_C PF15511.6 EEA08224.1 - 1.5e-08 34.7 0.1 1.9e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EEA08224.1 - 0.00034 20.9 0.0 0.00052 20.2 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 EEA08224.1 - 0.0014 18.7 0.1 0.0019 18.3 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EEA08224.1 - 0.0037 17.6 0.3 0.0042 17.4 0.3 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EEA08224.1 - 0.0087 16.1 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 EEA08224.1 - 0.036 14.5 0.1 0.049 14.0 0.1 1.4 1 1 0 1 1 1 0 CENP-S protein Bromo_TP PF07524.13 EEA08224.1 - 0.046 13.7 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EEA08224.1 - 0.1 12.4 0.1 0.12 12.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Thr_dehydrat_C PF00585.18 EEA08224.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase FbpA PF05833.11 EEA08224.1 - 0.18 10.5 0.0 0.21 10.3 0.0 1.0 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) zf-CCCH PF00642.24 EEA08225.1 - 3e-08 33.4 15.4 2.1e-05 24.3 1.9 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EEA08225.1 - 4.2e-05 23.3 0.0 8.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EEA08225.1 - 0.0013 19.4 9.2 0.26 12.0 3.8 2.6 2 1 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EEA08225.1 - 0.28 11.3 19.2 0.1 12.7 2.5 2.7 2 0 0 2 2 2 0 Zinc finger domain PHD PF00628.29 EEA08226.1 - 2.9e-15 55.9 27.1 4.4e-10 39.3 6.9 5.3 3 2 2 5 5 5 2 PHD-finger C1_2 PF03107.16 EEA08226.1 - 0.00077 19.7 6.4 0.00077 19.7 6.4 5.7 5 1 0 5 5 5 2 C1 domain SRP54 PF00448.22 EEA08227.1 - 2.4e-54 184.0 0.1 4.5e-54 183.1 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EEA08227.1 - 6.6e-13 49.2 20.9 2.3e-09 37.6 11.3 2.1 1 1 1 2 2 2 2 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 EEA08227.1 - 6.9e-06 26.2 0.1 2.9e-05 24.2 0.1 2.2 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EEA08227.1 - 2.1e-05 23.7 0.0 5.3e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EEA08227.1 - 0.00062 19.7 0.4 0.61 10.0 0.1 2.8 3 0 0 3 3 3 2 NTPase CbiA PF01656.23 EEA08227.1 - 0.0031 17.6 0.1 0.02 15.0 0.1 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EEA08227.1 - 0.0038 17.0 0.0 0.013 15.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EEA08227.1 - 0.0094 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 EEA08227.1 - 0.016 14.7 0.1 0.032 13.7 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 EEA08227.1 - 0.024 15.0 0.0 0.049 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Helicase_RecD PF05127.14 EEA08227.1 - 0.061 13.2 0.7 0.18 11.6 0.1 2.1 2 1 0 2 2 2 0 Helicase Zeta_toxin PF06414.12 EEA08227.1 - 0.071 12.4 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EEA08227.1 - 0.1 12.9 0.1 1.5 9.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_31 PF13614.6 EEA08227.1 - 0.31 10.9 8.5 0.66 9.9 0.1 3.1 2 2 2 4 4 4 0 AAA domain PseudoU_synth_1 PF01416.20 EEA08229.1 - 8.1e-30 103.5 0.0 7.2e-26 90.8 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 EEA08229.1 - 0.0096 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2344) Ribosomal_L12 PF00542.19 EEA08231.1 - 0.0042 17.4 14.8 0.59 10.5 0.5 5.2 2 2 2 5 5 5 3 Ribosomal protein L7/L12 C-terminal domain LPP PF04728.13 EEA08231.1 - 0.22 12.0 19.7 29 5.1 0.2 7.4 6 0 0 6 6 6 0 Lipoprotein leucine-zipper FliJ PF02050.16 EEA08231.1 - 8.3 6.7 25.3 2.5 8.3 5.4 4.8 1 1 1 3 3 3 0 Flagellar FliJ protein DUF3139 PF11337.8 EEA08232.1 - 0.11 13.1 8.6 1.7 9.4 0.7 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF3139) ApoC-I PF04691.12 EEA08233.1 - 0.00092 19.1 1.0 0.0014 18.5 1.0 1.3 1 0 0 1 1 1 1 Apolipoprotein C-I (ApoC-1) DUF507 PF04368.13 EEA08233.1 - 0.001 19.1 0.2 0.0012 18.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF507) Scm3 PF10384.9 EEA08233.1 - 0.064 13.0 0.1 0.098 12.4 0.1 1.3 1 0 0 1 1 1 0 Centromere protein Scm3 DUF4863 PF16155.5 EEA08233.1 - 0.095 12.6 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4863) zf-LYAR PF08790.11 EEA08239.1 - 0.022 14.6 1.2 0.064 13.2 1.2 1.8 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger Abhydrolase_2 PF02230.16 EEA08241.1 - 1.1e-27 97.3 0.0 8.5e-27 94.4 0.0 1.9 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EEA08241.1 - 7.9e-05 22.2 0.0 0.00034 20.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EEA08241.1 - 0.00028 20.6 0.0 0.00054 19.7 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Ribosomal_S13_N PF08069.12 EEA08241.1 - 0.091 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Ank_2 PF12796.7 EEA08242.1 - 1.1e-20 74.0 3.2 1.7e-09 38.1 0.1 5.3 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA08242.1 - 2.6e-13 50.2 6.9 6.5e-06 26.6 0.1 6.0 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EEA08242.1 - 2.6e-12 46.6 7.0 0.00066 20.0 0.2 6.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EEA08242.1 - 1.4e-10 40.4 10.3 0.068 13.8 0.0 7.5 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EEA08242.1 - 1.9e-09 37.6 5.0 6.9e-06 26.2 0.6 4.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) SIS PF01380.22 EEA08243.1 - 1.8e-42 144.3 0.7 4.6e-23 81.5 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EEA08243.1 - 3.7e-23 82.2 0.1 6.4e-23 81.4 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EEA08243.1 - 3.2e-17 62.6 0.0 7e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain bact-PGI_C PF10432.9 EEA08243.1 - 0.00045 20.3 0.0 0.0017 18.4 0.0 2.0 1 1 0 1 1 1 1 Bacterial phospho-glucose isomerase C-terminal SIS domain GATase_4 PF13230.6 EEA08243.1 - 0.0011 17.9 0.1 0.002 17.1 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 EEA08243.1 - 0.6 10.1 2.8 36 4.4 0.1 3.2 3 1 0 3 3 3 0 SIS domain Mannosyl_trans PF05007.13 EEA08244.1 - 8.5e-54 183.1 33.5 1.8e-53 182.1 33.5 1.5 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EEA08244.1 - 7.3e-10 38.4 39.6 7.3e-10 38.4 39.6 2.2 1 1 2 3 3 3 1 GPI transamidase subunit PIG-U PMT_2 PF13231.6 EEA08244.1 - 2.3e-05 24.7 4.7 2.3e-05 24.7 4.7 4.3 4 1 1 5 5 5 1 Dolichyl-phosphate-mannose-protein mannosyltransferase GT87 PF09594.10 EEA08244.1 - 0.0056 16.4 0.2 0.0056 16.4 0.2 2.4 3 0 0 3 3 3 1 Glycosyltransferase family 87 AMP-binding PF00501.28 EEA08245.1 - 1.4e-88 297.3 0.0 1.8e-88 297.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EEA08245.1 - 7.6e-22 78.1 0.1 1.5e-21 77.1 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EEA08245.1 - 2.9e-17 62.3 1.6 5.4e-17 61.5 0.4 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus WD40 PF00400.32 EEA08246.1 - 4.5e-25 87.4 16.9 0.00019 22.1 0.0 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA08246.1 - 1.3e-13 51.0 9.8 1.7e-05 25.0 0.5 4.2 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA08246.1 - 4.4e-08 33.2 0.3 0.21 11.4 0.0 3.2 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EEA08246.1 - 0.00012 21.2 0.1 0.015 14.3 0.0 2.8 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EEA08246.1 - 0.0039 15.9 5.0 0.061 12.0 0.1 2.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 TAXi_N PF14543.6 EEA08247.1 - 6.5e-20 72.1 1.6 9.5e-20 71.6 0.3 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp PF00026.23 EEA08247.1 - 3.1e-19 69.5 0.0 1.7e-11 44.1 0.0 3.1 2 2 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.6 EEA08247.1 - 5.2e-17 62.1 0.0 5.3e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal EGF PF00008.27 EEA08248.1 - 2.6e-12 46.8 35.3 9.5e-05 22.6 8.1 3.7 3 1 0 3 3 3 3 EGF-like domain EGF_2 PF07974.13 EEA08248.1 - 1.3e-08 35.1 41.6 0.0024 18.2 10.3 3.7 3 0 0 3 3 3 3 EGF-like domain EGF_3 PF12947.7 EEA08248.1 - 0.00014 22.0 29.0 0.16 12.2 8.2 3.6 2 1 1 3 3 3 3 EGF domain Plasmod_Pvs28 PF06247.11 EEA08248.1 - 0.00024 21.3 6.3 0.00024 21.3 6.3 3.7 2 1 0 3 3 3 1 Pvs28 EGF domain hEGF PF12661.7 EEA08248.1 - 0.00055 20.5 33.5 0.0057 17.2 4.0 5.4 4 1 1 5 5 5 4 Human growth factor-like EGF Laminin_EGF PF00053.24 EEA08248.1 - 0.013 15.6 25.1 0.79 9.9 3.8 3.5 1 1 2 3 3 3 0 Laminin EGF domain Oxidored_q2 PF00420.24 EEA08248.1 - 0.031 13.9 0.1 0.17 11.5 0.1 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF4208 PF13907.6 EEA08249.1 - 2.3e-09 37.5 0.0 3.2e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) SWIB PF02201.18 EEA08249.1 - 0.0061 16.4 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain MHC_I_2 PF14586.6 EEA08249.1 - 0.05 13.5 0.0 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 HBD PF18534.1 EEA08249.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Helical bundle domain DUF460 PF04312.13 EEA08249.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF460) SNF2_N PF00176.23 EEA08250.1 - 1.6e-62 211.2 2.4 4.2e-62 209.9 0.9 2.0 1 1 1 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.24 EEA08250.1 - 3.6e-22 78.0 5.8 4.5e-11 42.5 0.1 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EEA08250.1 - 1.1e-20 74.0 0.2 6.2e-20 71.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08250.1 - 3.4e-10 40.2 3.5 8.8e-10 38.9 0.0 3.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA08250.1 - 0.00014 21.7 0.0 0.022 14.5 0.0 3.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase PITH PF06201.13 EEA08251.1 - 6.7e-33 114.0 0.1 8.2e-33 113.8 0.1 1.1 1 0 0 1 1 1 1 PITH domain OppC_N PF12911.7 EEA08252.1 - 0.052 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C T6PP_N PF18572.1 EEA08253.1 - 1.5 8.7 8.1 10 6.1 0.2 3.8 4 0 0 4 4 4 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DLIC PF05783.11 EEA08254.1 - 2.1e-13 49.9 5.2 4.4e-10 39.0 0.0 2.9 3 0 0 3 3 3 2 Dynein light intermediate chain (DLIC) AAA_22 PF13401.6 EEA08254.1 - 0.028 14.7 0.0 0.11 12.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EEA08254.1 - 0.084 13.3 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 EEA08254.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain TAFII55_N PF04658.13 EEA08255.1 - 1.9e-16 60.2 0.0 6.3e-16 58.5 0.0 1.9 2 1 0 2 2 2 1 TAFII55 protein conserved region Patatin PF01734.22 EEA08256.1 - 3.2e-11 43.8 1.6 5.6e-10 39.7 1.6 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase DotA PF11388.8 EEA08257.1 - 0.031 14.5 0.1 0.092 13.0 0.1 1.7 1 0 0 1 1 1 0 Phagosome trafficking protein DotA Rax2 PF12768.7 EEA08259.1 - 0.0014 18.1 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF2561 PF10812.8 EEA08259.1 - 0.03 14.4 0.1 0.036 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) TMEM132D_C PF15706.5 EEA08259.1 - 0.04 13.7 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM154 PF15102.6 EEA08259.1 - 0.091 12.7 1.3 0.18 11.7 1.3 1.6 1 1 0 1 1 1 0 TMEM154 protein family PG_binding_2 PF08823.11 EEA08260.1 - 0.042 14.2 0.4 0.53 10.6 0.0 2.7 2 1 0 2 2 2 0 Putative peptidoglycan binding domain PAN_1 PF00024.26 EEA08261.1 - 0.001 19.0 0.1 0.001 19.0 0.1 2.2 2 0 0 2 2 2 1 PAN domain PAN_4 PF14295.6 EEA08261.1 - 0.02 14.8 0.9 0.052 13.5 0.9 1.7 1 0 0 1 1 1 0 PAN domain SSP160 PF06933.11 EEA08261.1 - 4.8 5.3 17.8 6.5 4.8 17.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TPR_19 PF14559.6 EEA08263.1 - 1.3e-05 25.6 0.5 2.1 8.9 0.0 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA08263.1 - 0.00018 21.8 4.1 1.5 9.2 0.0 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 EEA08263.1 - 0.00034 20.5 16.1 0.59 10.4 0.0 8.2 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA08263.1 - 0.0011 18.7 0.2 0.0011 18.7 0.2 8.5 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA08263.1 - 0.0034 17.9 4.2 3.6 8.4 0.0 6.4 8 0 0 8 8 8 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EEA08263.1 - 0.07 13.4 0.1 0.07 13.4 0.1 4.9 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EEA08263.1 - 0.12 13.3 0.6 1.2e+02 4.0 0.0 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EEA08263.1 - 0.18 12.1 17.1 37 4.9 0.1 8.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA08263.1 - 0.44 10.7 7.7 9.7 6.5 0.2 6.4 8 0 0 8 8 8 0 Tetratricopeptide repeat RRM_1 PF00076.22 EEA08264.1 - 3.8e-37 125.9 0.0 4.6e-18 64.8 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EEA08264.1 - 0.00029 20.8 0.0 0.034 14.2 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Limkain-b1 PF11608.8 EEA08264.1 - 0.0025 17.8 0.1 0.29 11.2 0.0 2.5 2 1 0 2 2 2 1 Limkain b1 RRM_7 PF16367.5 EEA08264.1 - 0.062 13.4 0.0 8 6.7 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif DUF4944 PF16302.5 EEA08264.1 - 0.13 12.4 0.1 55 3.8 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4944) AP2 PF00847.20 EEA08265.1 - 3.4e-11 43.2 2.7 7.5e-11 42.1 2.7 1.6 1 0 0 1 1 1 1 AP2 domain TSP_1 PF00090.19 EEA08266.1 - 3.1e-09 36.9 62.7 5.6e-07 29.7 9.0 7.2 5 2 2 7 7 7 5 Thrombospondin type 1 domain DUF2719 PF10891.8 EEA08266.1 - 0.12 12.2 0.8 0.6 10.0 0.8 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) TSP_1 PF00090.19 EEA08267.1 - 5.5e-28 96.9 90.9 3.1e-08 33.7 6.3 8.5 9 0 0 9 9 9 6 Thrombospondin type 1 domain PCI PF01399.27 EEA08269.1 - 1.7e-09 38.1 0.3 1.7e-09 38.1 0.3 3.2 3 2 0 3 3 3 1 PCI domain eIF3m_C_helix PF18005.1 EEA08269.1 - 8.3e-06 25.4 0.1 1.7e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix DUF4729 PF15866.5 EEA08269.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4729) AAA_24 PF13479.6 EEA08269.1 - 0.1 12.3 0.1 0.46 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain FHA PF00498.26 EEA08270.1 - 1.2e-13 51.2 0.2 3.1e-13 49.9 0.1 1.8 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EEA08270.1 - 5.3e-05 23.5 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain F_actin_cap_B PF01115.17 EEA08271.1 - 3.3e-59 200.4 5.0 4.4e-59 200.0 5.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit NAP PF00956.18 EEA08271.1 - 0.07 12.3 1.4 3 6.9 0.3 2.4 2 0 0 2 2 2 0 Nucleosome assembly protein (NAP) MKLP1_Arf_bdg PF16540.5 EEA08271.1 - 0.12 12.5 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Arf6-interacting domain of mitotic kinesin-like protein 1 Dus PF01207.17 EEA08273.1 - 1.1e-69 235.0 0.0 1.5e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EEA08273.1 - 2.8e-06 27.0 0.0 4.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 EEA08273.1 - 0.0064 15.8 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EEA08273.1 - 0.049 12.6 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.21 EEA08273.1 - 0.064 12.5 0.0 1 8.5 0.0 2.1 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase ERCC4 PF02732.15 EEA08274.1 - 2.1e-21 76.7 0.1 1.1e-20 74.4 0.0 2.4 1 1 1 2 2 2 1 ERCC4 domain HTH_45 PF14947.6 EEA08274.1 - 0.002 18.1 1.2 0.012 15.6 0.2 2.9 2 0 0 2 2 2 1 Winged helix-turn-helix HHH_8 PF14716.6 EEA08274.1 - 0.035 14.5 0.1 0.24 11.8 0.0 2.5 3 0 0 3 3 3 0 Helix-hairpin-helix domain Sld5 PF05916.11 EEA08275.1 - 3.4e-12 46.8 0.1 4.5e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 GINS complex protein AAA PF00004.29 EEA08277.1 - 1e-40 139.2 0.0 2.2e-40 138.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EEA08277.1 - 2.5e-14 53.0 0.0 8.5e-14 51.3 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EEA08277.1 - 3.4e-10 39.8 0.8 9.3e-10 38.4 0.8 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 EEA08277.1 - 6.6e-06 26.0 0.0 1.4e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EEA08277.1 - 1.9e-05 24.9 0.0 5.9e-05 23.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EEA08277.1 - 3.3e-05 24.3 0.1 0.0015 18.9 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EEA08277.1 - 5.1e-05 23.3 0.1 0.00035 20.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EEA08277.1 - 8.3e-05 22.9 0.5 0.045 14.0 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EEA08277.1 - 8.6e-05 22.6 0.0 0.00021 21.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase PF06745.13 EEA08277.1 - 0.00058 19.3 0.2 0.45 9.8 0.0 2.5 1 1 1 2 2 2 2 KaiC AAA_33 PF13671.6 EEA08277.1 - 0.00075 19.7 0.1 0.0026 17.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EEA08277.1 - 0.001 18.8 0.0 0.0034 17.2 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.13 EEA08277.1 - 0.0014 17.9 0.0 0.0043 16.3 0.0 1.8 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 EEA08277.1 - 0.0017 18.1 0.1 0.005 16.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EEA08277.1 - 0.0022 18.4 0.1 0.0099 16.3 0.0 2.3 2 0 0 2 2 2 1 RNA helicase Bac_DnaA PF00308.18 EEA08277.1 - 0.0026 17.6 0.0 0.019 14.8 0.0 2.1 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_18 PF13238.6 EEA08277.1 - 0.0027 18.3 0.6 0.012 16.1 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EEA08277.1 - 0.0085 15.6 0.2 0.048 13.2 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region PhoH PF02562.16 EEA08277.1 - 0.016 14.7 0.1 0.039 13.4 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF815 PF05673.13 EEA08277.1 - 0.019 14.2 0.0 0.036 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_lid_3 PF17862.1 EEA08277.1 - 0.022 14.6 0.0 0.057 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA+ lid domain Mg_chelatase PF01078.21 EEA08277.1 - 0.029 13.8 0.0 0.067 12.6 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EEA08277.1 - 0.036 13.6 0.4 0.37 10.4 0.1 2.2 1 1 1 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EEA08277.1 - 0.056 12.5 2.2 0.12 11.4 0.6 2.4 2 1 0 2 2 2 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 EEA08277.1 - 0.096 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GPI2 PF06432.11 EEA08278.1 - 1.9e-31 109.6 22.9 6.3e-31 107.9 22.9 1.7 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Myb_DNA-binding PF00249.31 EEA08280.1 - 4e-07 30.1 0.2 1.5e-06 28.3 0.2 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EEA08280.1 - 0.0046 17.2 0.1 0.0046 17.2 0.1 3.5 5 0 0 5 5 5 1 Myb-like DNA-binding domain GBP PF02263.19 EEA08281.1 - 2e-19 69.9 1.0 2e-19 69.9 1.0 2.2 1 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 EEA08281.1 - 0.0021 18.1 0.9 0.0066 16.5 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase eIF-5a PF01287.20 EEA08281.1 - 0.0052 16.9 3.1 0.0059 16.7 0.0 2.7 3 0 0 3 3 3 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Dynamin_N PF00350.23 EEA08281.1 - 0.73 9.9 3.9 0.49 10.4 0.5 2.4 2 0 0 2 2 2 0 Dynamin family SpmSyn_N PF17950.1 EEA08281.1 - 2.1 8.6 5.9 22 5.4 0.1 3.2 3 0 0 3 3 3 0 S-adenosylmethionine decarboxylase N -terminal RRM_1 PF00076.22 EEA08282.1 - 1.1e-38 130.8 0.4 9e-19 67.1 0.3 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA08282.1 - 0.0011 19.0 0.1 0.011 15.8 0.1 2.4 2 1 0 2 2 2 1 RNA recognition motif Cas_Cas2CT1978 PF09707.10 EEA08282.1 - 0.0066 16.5 0.0 0.39 10.8 0.0 2.2 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Cas2CT1978) OB_RNB PF08206.11 EEA08282.1 - 0.014 15.1 0.6 2.2 8.0 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Ank_2 PF12796.7 EEA08283.1 - 4.8e-37 126.4 0.1 9.4e-15 55.0 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA08283.1 - 2.7e-36 123.5 6.9 1.4e-10 41.5 0.0 6.1 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA08283.1 - 1.4e-32 111.3 0.3 8.1e-08 32.4 0.0 5.0 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EEA08283.1 - 2e-32 107.5 3.4 2.3e-05 24.4 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EEA08283.1 - 3.6e-29 99.9 2.4 7e-06 26.3 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat RNA_GG_bind PF10258.9 EEA08283.1 - 8.6e-27 93.0 0.1 1.6e-26 92.2 0.1 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain Mg_trans_NIPA PF05653.14 EEA08285.1 - 7.5e-14 51.5 21.6 1.2e-13 50.9 21.6 1.3 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EEA08285.1 - 0.0002 21.5 9.0 0.0002 21.5 9.0 3.6 2 2 1 3 3 3 1 EamA-like transporter family DUF202 PF02656.15 EEA08285.1 - 0.097 13.1 0.5 0.097 13.1 0.5 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Arm PF00514.23 EEA08286.1 - 0.0084 16.1 17.3 0.013 15.5 0.5 8.4 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat NUC130_3NT PF08158.12 EEA08286.1 - 0.025 14.9 0.0 9.7 6.6 0.0 3.7 3 0 0 3 3 3 0 NUC130/3NT domain DUF3730 PF12530.8 EEA08286.1 - 0.031 13.8 9.8 2.4 7.7 0.2 5.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3730) Pico_P2B PF01552.17 EEA08286.1 - 0.039 14.1 7.0 0.12 12.5 0.0 4.5 4 0 0 4 4 4 0 Picornavirus 2B protein Spc7_C2 PF15577.6 EEA08286.1 - 0.054 13.6 0.6 0.2 11.8 0.1 2.3 2 0 0 2 2 2 0 Spc7_C2 UME PF08064.13 EEA08286.1 - 0.094 12.6 0.2 2.3 8.2 0.1 3.7 2 0 0 2 2 2 0 UME (NUC010) domain UNC45-central PF11701.8 EEA08286.1 - 0.18 11.8 17.3 0.15 12.0 1.3 5.9 6 0 0 6 6 6 0 Myosin-binding striated muscle assembly central PAXNEB PF05625.11 EEA08286.1 - 0.19 10.8 2.7 0.21 10.7 0.5 2.2 2 0 0 2 2 2 0 PAXNEB protein DUF2013 PF09431.10 EEA08286.1 - 2.3 8.4 8.8 4.3 7.5 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF2013) zf-Tim10_DDP PF02953.15 EEA08287.1 - 1.8e-15 56.4 2.8 2.2e-15 56.0 2.8 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger NCD3G PF07562.14 EEA08287.1 - 0.01 15.8 3.4 0.016 15.2 3.4 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR FBPase_2 PF06874.11 EEA08287.1 - 0.071 11.4 0.1 0.079 11.2 0.1 1.0 1 0 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase Helicase_C PF00271.31 EEA08290.1 - 7.1e-20 71.4 0.0 2.2e-18 66.6 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EEA08290.1 - 1.6e-18 67.1 0.0 3.8e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EEA08290.1 - 3.5e-12 46.9 2.5 3.5e-12 46.9 2.5 2.4 2 0 0 2 2 2 1 RecQ zinc-binding HRDC PF00570.23 EEA08290.1 - 2.4e-06 27.4 0.0 6e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 EEA08290.1 - 4.8e-05 23.4 0.0 0.00027 21.0 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit RQC PF09382.10 EEA08290.1 - 0.018 14.8 0.1 0.088 12.6 0.0 2.2 2 0 0 2 2 2 0 RQC domain UPF0167 PF03691.14 EEA08290.1 - 0.05 13.4 0.2 0.13 12.0 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) DNA_pol_B PF00136.21 EEA08291.1 - 1e-132 443.2 0.7 1.5e-132 442.6 0.7 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EEA08291.1 - 2.5e-63 214.3 8.4 4.6e-63 213.4 8.4 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EEA08291.1 - 2.3e-14 53.6 13.0 2.3e-14 53.6 13.0 1.9 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta ProRS-C_1 PF09180.11 EEA08292.1 - 1.5e-25 89.2 0.4 4.4e-25 87.7 0.4 1.9 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EEA08292.1 - 7.5e-22 78.2 0.0 3.7e-21 75.9 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 EEA08292.1 - 2.6e-20 72.8 0.0 6e-20 71.6 0.0 1.6 2 0 0 2 2 2 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 EEA08292.1 - 4.8e-19 68.3 0.2 5.5e-18 64.9 0.1 2.4 2 0 0 2 2 2 1 Anticodon binding domain Mannitol_dh PF01232.23 EEA08293.1 - 0.19 11.9 2.1 6.4 6.9 0.1 2.5 2 0 0 2 2 2 0 Mannitol dehydrogenase Rossmann domain EF-hand_13 PF17958.1 EEA08294.1 - 0.079 12.8 0.1 0.28 11.0 0.1 2.0 2 0 0 2 2 2 0 EF-hand domain RRM_1 PF00076.22 EEA08295.1 - 5.6e-09 35.7 0.0 1.1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 EEA08295.1 - 0.0047 17.2 0.2 0.018 15.4 0.2 2.0 1 0 0 1 1 1 1 PWI domain DUF973 PF06157.11 EEA08296.1 - 0.071 12.1 2.8 0.11 11.5 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) PEP-CTERM PF07589.11 EEA08296.1 - 0.66 10.1 0.0 0.66 10.1 0.0 2.7 3 0 0 3 3 3 0 PEP-CTERM motif DUF2207 PF09972.9 EEA08296.1 - 8.1 5.1 6.9 24 3.5 6.9 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) AAA PF00004.29 EEA08297.1 - 1e-39 136.0 0.0 1.9e-39 135.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EEA08297.1 - 3.1e-11 42.9 0.1 6.6e-11 41.8 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EEA08297.1 - 2.1e-05 24.5 0.0 7.8e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EEA08297.1 - 2.2e-05 24.7 0.2 0.0094 16.2 0.0 2.6 2 1 1 3 3 2 1 AAA domain AAA_16 PF13191.6 EEA08297.1 - 6.8e-05 23.3 0.2 0.0036 17.7 0.1 2.3 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EEA08297.1 - 0.00086 19.1 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EEA08297.1 - 0.001 19.2 0.0 0.0037 17.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EEA08297.1 - 0.0053 16.3 0.0 0.019 14.4 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 EEA08297.1 - 0.011 16.3 0.0 0.038 14.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EEA08297.1 - 0.013 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EEA08297.1 - 0.016 15.4 0.1 0.047 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EEA08297.1 - 0.016 15.4 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 EEA08297.1 - 0.025 14.9 0.1 0.15 12.4 0.0 2.4 3 0 0 3 3 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_24 PF13479.6 EEA08297.1 - 0.034 13.9 0.1 0.11 12.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 EEA08297.1 - 0.048 12.9 0.0 0.097 11.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EEA08297.1 - 0.052 12.9 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 EEA08297.1 - 0.062 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EEA08297.1 - 0.12 11.4 0.0 0.24 10.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein zf_Rg PF17915.1 EEA08297.1 - 0.14 11.6 0.1 0.28 10.6 0.1 1.4 1 0 0 1 1 1 0 Reverse gyrase zinc finger ATPase PF06745.13 EEA08297.1 - 0.14 11.5 0.1 1.3 8.4 0.0 2.4 3 0 0 3 3 3 0 KaiC IstB_IS21 PF01695.17 EEA08297.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 EEA08297.1 - 0.18 11.5 0.0 0.52 10.0 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EEA08297.1 - 0.19 12.1 0.0 0.39 11.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Myosin_head PF00063.21 EEA08298.1 - 3.1e-211 703.2 0.7 2.9e-210 700.0 0.7 2.5 1 1 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 EEA08298.1 - 7.4e-08 31.5 8.7 0.021 14.6 0.2 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif Myosin_N PF02736.19 EEA08298.1 - 0.0014 18.4 0.0 0.0034 17.2 0.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 EEA08298.1 - 0.07 13.5 0.4 8.1 6.8 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EEA08298.1 - 0.1 12.9 3.8 0.5 10.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EEA08298.1 - 0.11 11.8 0.0 0.41 10.0 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family zf-ZPR1 PF03367.13 EEA08298.1 - 2.9 7.7 10.2 3.2 7.6 1.2 3.5 3 0 0 3 3 3 0 ZPR1 zinc-finger domain His_Phos_1 PF00300.22 EEA08299.1 - 1e-16 61.2 0.0 3.7e-05 23.5 0.0 3.2 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) Ribosomal_S7 PF00177.21 EEA08300.1 - 1.9e-37 128.2 0.5 2.4e-37 127.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e TRAPPC-Trs85 PF12739.7 EEA08301.1 - 1.8e-63 215.0 4.6 3.1e-63 214.1 4.6 1.4 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SNAP PF14938.6 EEA08301.1 - 0.04 13.3 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Phage_int_SAM_5 PF13102.6 EEA08302.1 - 0.57 10.6 9.0 1.7 9.0 8.0 2.5 1 1 0 1 1 1 0 Phage integrase SAM-like domain DUF4763 PF15960.5 EEA08302.1 - 0.71 9.1 36.7 0.22 10.8 22.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) PI3K_P85_iSH2 PF16454.5 EEA08302.1 - 0.86 9.2 37.0 0.029 14.0 27.4 2.6 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4201 PF13870.6 EEA08302.1 - 1.9 8.2 53.6 0.044 13.5 30.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) FlxA PF14282.6 EEA08302.1 - 2.2 8.3 58.2 0.027 14.5 13.2 4.0 2 1 1 4 4 4 0 FlxA-like protein TolA_bind_tri PF16331.5 EEA08302.1 - 6.8 6.8 41.4 0.38 10.8 0.9 4.9 4 1 1 5 5 5 0 TolA binding protein trimerisation Syntaxin-6_N PF09177.11 EEA08302.1 - 7.3 7.2 29.9 2.8 8.5 12.6 3.4 3 1 0 3 3 3 0 Syntaxin 6, N-terminal PseudoU_synth_2 PF00849.22 EEA08303.1 - 0.0028 17.8 0.1 0.009 16.1 0.0 1.9 2 0 0 2 2 2 1 RNA pseudouridylate synthase 2-oxoacid_dh PF00198.23 EEA08305.1 - 9.2e-74 247.8 0.0 1.5e-73 247.1 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EEA08305.1 - 8.8e-15 54.3 1.6 1.2e-14 53.9 0.7 1.7 2 0 0 2 2 2 1 Biotin-requiring enzyme HlyD_3 PF13437.6 EEA08305.1 - 0.018 15.8 0.3 0.66 10.7 0.0 2.4 1 1 1 2 2 2 0 HlyD family secretion protein GCV_H PF01597.19 EEA08305.1 - 0.029 14.3 0.1 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Glycine cleavage H-protein ATP_bind_1 PF03029.17 EEA08306.1 - 4.9e-78 262.2 0.1 5.6e-78 262.1 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EEA08306.1 - 0.0021 18.6 0.0 0.0037 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Orthopox_A47 PF06334.11 EEA08306.1 - 0.0052 16.1 0.1 0.0092 15.3 0.1 1.3 1 0 0 1 1 1 1 Orthopoxvirus A47 protein CLP1_P PF16575.5 EEA08306.1 - 0.0087 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 EEA08306.1 - 0.058 13.1 0.0 0.091 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EEA08306.1 - 0.096 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 EEA08306.1 - 0.19 11.6 0.1 17 5.3 0.0 2.5 3 0 0 3 3 3 0 NTPase CS PF04969.16 EEA08307.1 - 0.00076 20.5 4.1 0.00076 20.5 4.1 1.7 2 0 0 2 2 2 1 CS domain CDC37_N PF03234.14 EEA08307.1 - 0.062 14.2 1.9 0.062 14.2 1.9 1.8 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DUF5615 PF18480.1 EEA08308.1 - 0.062 13.1 0.0 0.27 11.0 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) Flu_NS2 PF00601.19 EEA08308.1 - 0.12 12.7 2.7 0.4 11.0 0.0 3.4 3 1 0 3 3 3 0 Influenza non-structural protein (NS2) Mo25 PF08569.11 EEA08309.1 - 6.5e-58 196.6 26.1 6.3e-56 190.1 24.8 2.4 1 1 0 1 1 1 1 Mo25-like RabGAP-TBC PF00566.18 EEA08310.1 - 5.7e-55 186.3 0.9 8.6e-55 185.7 0.9 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Kinesin PF00225.23 EEA08311.1 - 1.2e-108 363.1 2.4 1.2e-108 363.1 2.4 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EEA08311.1 - 1.6e-23 83.3 0.1 1.6e-23 83.3 0.1 4.2 3 1 1 4 4 4 1 Microtubule binding Mit_KHE1 PF10173.9 EEA08311.1 - 0.0068 16.5 0.5 0.0068 16.5 0.5 2.7 1 1 1 2 2 2 1 Mitochondrial K+-H+ exchange-related Protoglobin PF11563.8 EEA08311.1 - 0.046 13.6 1.7 0.67 9.8 1.7 2.7 1 1 0 1 1 1 0 Protoglobin AAA PF00004.29 EEA08311.1 - 0.059 13.8 0.2 7.3 7.0 0.0 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Kri1 PF05178.12 EEA08311.1 - 0.1 13.2 2.3 2.3 8.8 0.3 3.2 2 0 0 2 2 2 0 KRI1-like family DNA_ligase_A_N PF04675.14 EEA08311.1 - 0.14 12.4 0.0 0.14 12.4 0.0 3.4 4 0 0 4 4 4 0 DNA ligase N terminus CNDH2_N PF06278.11 EEA08311.1 - 0.37 11.0 8.5 0.047 13.9 1.6 2.7 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Phasin PF05597.11 EEA08311.1 - 0.62 10.1 11.1 2.1 8.4 0.9 4.5 4 1 1 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Apolipoprotein PF01442.18 EEA08311.1 - 1 9.2 7.7 0.81 9.5 0.3 2.7 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain SlyX PF04102.12 EEA08311.1 - 4.1 8.1 16.0 0.058 14.0 1.3 4.9 5 0 0 5 5 4 0 SlyX DUF4208 PF13907.6 EEA08311.1 - 4.9 7.7 7.2 8.6 6.9 0.0 3.7 4 0 0 4 4 3 0 Domain of unknown function (DUF4208) Metallophos PF00149.28 EEA08312.1 - 3e-34 119.3 0.2 6.2e-34 118.3 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_L16 PF00252.18 EEA08313.1 - 1.3e-42 144.9 0.1 1.7e-42 144.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e UQ_con PF00179.26 EEA08314.1 - 2.4e-40 137.4 0.3 2.9e-40 137.2 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EEA08314.1 - 0.018 15.3 0.3 0.043 14.1 0.2 1.6 1 1 0 1 1 1 0 RWD domain EF-hand_7 PF13499.6 EEA08316.1 - 5.4e-06 26.8 0.1 0.00093 19.6 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EEA08316.1 - 0.0011 18.7 0.4 0.016 15.1 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EEA08316.1 - 0.0022 17.4 0.0 0.049 13.2 0.0 2.8 2 0 0 2 2 2 1 EF hand FH2 PF02181.23 EEA08318.1 - 7.3e-79 265.6 0.3 1.4e-78 264.7 0.3 1.5 1 0 0 1 1 1 1 Formin Homology 2 Domain TPR_12 PF13424.6 EEA08318.1 - 7e-09 35.9 0.7 0.00057 20.1 0.0 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA08318.1 - 0.00013 21.9 5.1 3.9 7.9 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EEA08318.1 - 0.00042 20.1 0.0 0.97 9.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat HsbA PF12296.8 EEA08318.1 - 0.018 15.4 1.2 1.7 9.1 0.5 3.1 2 0 0 2 2 2 0 Hydrophobic surface binding protein A TPR_2 PF07719.17 EEA08318.1 - 0.049 13.8 6.7 30 5.1 0.4 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EEA08318.1 - 0.47 10.4 9.7 2.7 8.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4167 PF13763.6 EEA08318.1 - 2.4 8.3 5.0 0.82 9.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4167) Ndc80_HEC PF03801.13 EEA08319.1 - 7.4e-27 93.8 0.0 2.2e-26 92.3 0.0 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family DUF4407 PF14362.6 EEA08319.1 - 4.8 6.5 23.9 1.2 8.4 5.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CIAPIN1 PF05093.13 EEA08320.1 - 2.4e-19 69.7 12.4 9.9e-18 64.5 12.4 2.2 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Med29 PF11568.8 EEA08321.1 - 0.09 13.0 0.0 1.4 9.1 0.0 2.0 2 0 0 2 2 2 0 Mediator complex subunit 29 Hydrolase_4 PF12146.8 EEA08323.1 - 3.4e-16 59.2 0.0 5.1e-08 32.5 0.0 3.1 3 1 0 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA08323.1 - 0.0017 18.0 0.0 0.0055 16.4 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1668 PF07893.13 EEA08323.1 - 0.16 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1668) DRMBL PF07522.14 EEA08323.1 - 0.3 11.3 2.1 0.89 9.8 0.1 2.7 3 0 0 3 3 3 0 DNA repair metallo-beta-lactamase NT-C2 PF10358.9 EEA08324.1 - 5.4e-24 84.6 0.9 2.1e-23 82.7 0.0 2.4 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins DUF5624 PF18538.1 EEA08324.1 - 0.0097 16.0 5.5 0.84 9.7 0.4 2.9 1 1 1 2 2 2 2 Domain of unknown function (DUF5624) Coiled-coil_56 PF09813.9 EEA08324.1 - 0.42 10.7 4.5 0.34 11.0 0.1 2.8 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 56 Csm1_N PF18504.1 EEA08324.1 - 3.9 7.9 21.1 1.4 9.3 2.5 4.1 3 0 0 3 3 3 0 Csm1 N-terminal domain TMEM208_SND2 PF05620.11 EEA08325.1 - 6.9e-13 48.7 13.2 2.6e-11 43.6 13.2 2.0 1 1 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 AC_N PF16214.5 EEA08325.1 - 2.2 7.3 5.5 2.6 7.1 5.5 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Cullin PF00888.22 EEA08327.1 - 2.2e-37 129.0 20.2 5.4e-36 124.4 20.1 2.3 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EEA08327.1 - 3.5e-05 23.7 5.0 9.7e-05 22.3 5.0 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain PDEase_I PF00233.19 EEA08329.1 - 1.3e-56 192.0 4.1 2.9e-56 190.9 4.1 1.7 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EEA08329.1 - 0.076 13.2 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 HD domain Rod_cone_degen PF15201.6 EEA08331.1 - 0.0037 17.3 1.6 1.4 9.1 0.1 3.5 3 0 0 3 3 3 1 Progressive rod-cone degeneration ATP_sub_h PF10775.9 EEA08331.1 - 0.02 14.9 3.4 2.6 8.1 0.3 2.7 2 0 0 2 2 2 0 ATP synthase complex subunit h DUF1825 PF08855.10 EEA08333.1 - 0.27 11.2 2.7 0.7 9.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) DHHC PF01529.20 EEA08334.1 - 2.7e-34 118.1 6.2 2.7e-34 118.1 6.2 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase UCH PF00443.29 EEA08335.1 - 9e-45 153.2 2.7 1.5e-44 152.4 2.7 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA08335.1 - 7.6e-22 78.3 0.5 5.3e-21 75.5 0.5 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EEA08335.1 - 1.5e-10 41.2 0.0 8.3e-10 38.8 0.0 2.4 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EEA08335.1 - 2e-09 37.1 0.1 6e-09 35.5 0.1 1.8 1 0 0 1 1 1 1 Variant UBP zinc finger UBA PF00627.31 EEA08335.1 - 0.0018 18.2 0.0 0.064 13.2 0.0 2.6 2 0 0 2 2 2 1 UBA/TS-N domain zf-Sec23_Sec24 PF04810.15 EEA08335.1 - 0.23 11.5 2.9 13 6.0 0.3 3.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Myosin_head PF00063.21 EEA08336.1 - 2.2e-192 640.9 4.2 4.4e-192 639.9 4.2 1.5 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 EEA08336.1 - 1.2e-13 49.5 25.5 0.0044 16.7 0.2 6.8 6 0 0 6 6 6 4 IQ calmodulin-binding motif WD40 PF00400.32 EEA08336.1 - 2.7e-09 37.5 0.6 0.032 15.1 0.1 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat RILP PF11461.8 EEA08336.1 - 0.0098 16.1 1.9 0.03 14.6 1.9 1.8 1 0 0 1 1 1 1 Rab interacting lysosomal protein DUF4598 PF15370.6 EEA08336.1 - 0.011 16.2 2.5 0.025 15.1 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) DUF4448 PF14610.6 EEA08336.1 - 0.055 13.2 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) AAA_16 PF13191.6 EEA08336.1 - 0.1 13.0 0.4 0.7 10.2 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain Jnk-SapK_ap_N PF09744.9 EEA08336.1 - 0.39 10.9 8.5 0.79 9.9 8.5 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Seryl_tRNA_N PF02403.22 EEA08336.1 - 0.53 10.5 7.9 0.14 12.4 3.0 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Occludin_ELL PF07303.13 EEA08336.1 - 5.5 7.8 11.0 0.76 10.5 4.7 2.6 2 0 0 2 2 2 0 Occludin homology domain DUF4349 PF14257.6 EEA08336.1 - 8.8 5.7 6.5 16 4.8 6.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TolA_bind_tri PF16331.5 EEA08336.1 - 9.3 6.4 10.5 25 5.0 2.4 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation Gln-synt_C PF00120.24 EEA08337.1 - 4.5e-105 351.5 0.0 5.3e-105 351.2 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EEA08337.1 - 7.2e-21 73.7 0.3 1.6e-20 72.6 0.3 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain RNA_pol_Rpc34 PF05158.12 EEA08338.1 - 9.1e-38 130.5 8.4 3.9e-35 121.8 0.5 2.9 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit DUF5382 PF17354.2 EEA08338.1 - 0.0017 17.3 0.3 0.0029 16.5 0.3 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5382) B-block_TFIIIC PF04182.12 EEA08338.1 - 0.01 16.0 0.2 0.031 14.4 0.0 1.9 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC Ank_2 PF12796.7 EEA08339.1 - 2.8e-34 117.5 7.2 1.4e-14 54.5 0.2 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EEA08339.1 - 4.8e-24 84.4 4.6 1.1e-07 32.2 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EEA08339.1 - 2.6e-23 81.8 4.7 1.8e-06 28.1 0.0 5.1 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EEA08339.1 - 3e-21 74.8 5.7 0.0002 21.7 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EEA08339.1 - 2.4e-20 70.5 2.7 0.00062 20.0 0.0 4.8 5 0 0 5 5 5 4 Ankyrin repeat HTH_24 PF13412.6 EEA08339.1 - 0.061 12.9 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding PIG-H PF10181.9 EEA08340.1 - 3.8e-08 33.1 3.1 1.3e-07 31.4 1.6 2.2 2 0 0 2 2 2 1 GPI-GlcNAc transferase complex, PIG-H component DUF2207 PF09972.9 EEA08340.1 - 9.5 4.9 11.4 12 4.5 11.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 EEA08341.1 - 4.8e-22 77.8 11.7 5.6e-05 23.8 0.6 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EEA08341.1 - 9.9e-07 29.0 0.0 1.3 9.4 0.1 5.4 2 1 5 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EEA08341.1 - 8.5e-05 22.5 0.2 2 8.2 0.0 3.2 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EEA08341.1 - 0.014 14.1 0.7 3.6 6.1 0.2 3.2 3 1 1 4 4 4 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EEA08341.1 - 0.16 10.4 0.0 0.43 9.1 0.0 1.6 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ribosomal_L26 PF16906.5 EEA08342.1 - 2.9e-36 123.8 3.0 3.8e-36 123.4 3.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EEA08342.1 - 2.4e-05 24.1 0.9 4.9e-05 23.1 0.9 1.5 1 0 0 1 1 1 1 KOW motif Methyltrans_RNA PF04452.14 EEA08342.1 - 0.014 14.7 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 RNA methyltransferase Ribosomal_S8e PF01201.22 EEA08343.1 - 3.7e-53 179.4 0.1 4.6e-53 179.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Glyco_transf_34 PF05637.12 EEA08345.1 - 3.3e-05 23.8 6.7 0.0011 18.8 2.4 3.3 1 1 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family Spt5-NGN PF03439.13 EEA08346.1 - 2e-16 59.7 0.2 7.3e-16 57.8 0.0 2.2 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EEA08346.1 - 4.2e-14 51.9 0.2 0.069 13.1 0.0 6.0 5 0 0 5 5 5 4 KOW motif Spt5_N PF11942.8 EEA08346.1 - 0.0005 21.0 7.2 0.0005 21.0 7.2 1.9 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal Ras PF00071.22 EEA08347.1 - 2.1e-61 206.3 0.3 3.1e-61 205.7 0.3 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EEA08347.1 - 4.5e-36 123.7 0.1 8.7e-36 122.8 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EEA08347.1 - 4.7e-16 58.7 0.1 6.7e-16 58.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EEA08347.1 - 3.9e-09 36.2 0.9 5.4e-09 35.7 0.9 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA08347.1 - 2.9e-05 24.1 0.2 5.6e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA08347.1 - 0.00017 21.2 0.0 0.00072 19.1 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EEA08347.1 - 0.00071 19.5 0.2 0.91 9.4 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EEA08347.1 - 0.012 15.2 0.1 0.055 13.0 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.18 EEA08347.1 - 0.028 13.7 0.8 0.097 11.9 0.0 2.1 2 1 1 3 3 3 0 Septin AAA_16 PF13191.6 EEA08347.1 - 0.091 13.1 0.0 0.12 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 EEA08347.1 - 0.1 12.0 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 EEA08347.1 - 0.12 12.8 0.0 0.88 10.0 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Presenilin PF01080.17 EEA08348.1 - 7.2 5.3 32.9 12 4.5 32.9 1.3 1 0 0 1 1 1 0 Presenilin DUF3449 PF11931.8 EEA08349.1 - 7.4e-67 224.7 1.1 7.4e-67 224.7 1.1 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EEA08349.1 - 1.2e-18 67.4 5.9 6.7e-18 65.0 5.9 2.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 EEA08349.1 - 0.00019 21.7 1.0 0.18 12.2 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type SF3a60_bindingd PF12108.8 EEA08349.1 - 0.0029 17.5 1.2 0.004 17.0 0.1 1.9 2 0 0 2 2 2 1 Splicing factor SF3a60 binding domain Rft-1 PF04506.13 EEA08350.1 - 1.6e-42 146.0 40.0 2e-42 145.7 40.0 1.0 1 0 0 1 1 1 1 Rft protein SAC3_GANP PF03399.16 EEA08351.1 - 3.9e-19 69.2 14.9 1.6e-18 67.1 10.5 2.9 2 1 0 2 2 2 1 SAC3/GANP family DUF724 PF05266.14 EEA08351.1 - 0.037 13.9 0.1 0.13 12.1 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) AlphaC_C PF17480.2 EEA08351.1 - 0.07 13.2 0.2 0.07 13.2 0.2 2.3 2 0 0 2 2 2 0 AlphaC C-terminal ABC_membrane PF00664.23 EEA08352.1 - 1.7e-75 254.2 35.5 4.4e-40 138.1 9.3 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EEA08352.1 - 5.9e-48 162.9 0.0 7.8e-33 113.9 0.0 2.9 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EEA08352.1 - 4.2e-10 39.4 0.1 3.5e-06 26.6 1.8 4.1 3 2 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EEA08352.1 - 2.7e-08 33.9 8.7 0.00037 20.3 0.9 3.3 2 2 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EEA08352.1 - 1.3e-06 28.5 0.0 0.024 14.5 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EEA08352.1 - 3.7e-06 27.0 3.4 0.065 13.0 0.8 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 EEA08352.1 - 1.8e-05 24.1 0.0 0.004 16.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 EEA08352.1 - 8.6e-05 23.1 0.5 0.16 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain PRK PF00485.18 EEA08352.1 - 0.00011 22.0 0.0 0.56 9.9 0.0 2.8 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 EEA08352.1 - 0.00017 22.0 0.0 0.51 10.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 EEA08352.1 - 0.00018 22.1 0.1 0.23 12.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EEA08352.1 - 0.00036 21.0 0.0 0.63 10.5 0.0 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EEA08352.1 - 0.0012 18.0 0.1 0.22 10.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ABC_ATPase PF09818.9 EEA08352.1 - 0.0014 17.6 0.3 0.0032 16.3 0.0 1.7 2 0 0 2 2 2 1 Predicted ATPase of the ABC class G-alpha PF00503.20 EEA08352.1 - 0.0014 17.8 0.0 1 8.4 0.0 2.6 2 0 0 2 2 2 2 G-protein alpha subunit AAA_29 PF13555.6 EEA08352.1 - 0.0018 18.0 1.7 0.46 10.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA08352.1 - 0.0026 18.0 0.1 3.9 7.7 0.1 3.1 2 1 0 2 2 2 1 AAA domain tRNA_lig_kinase PF08303.11 EEA08352.1 - 0.0047 17.0 0.3 2.3 8.3 0.0 3.2 3 0 0 3 3 3 1 tRNA ligase kinase domain AAA_7 PF12775.7 EEA08352.1 - 0.0049 16.4 0.0 0.75 9.3 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EEA08352.1 - 0.015 15.4 0.0 1.2 9.2 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rad17 PF03215.15 EEA08352.1 - 0.029 14.3 0.0 16 5.4 0.0 3.2 3 0 0 3 3 3 0 Rad17 P-loop domain MobB PF03205.14 EEA08352.1 - 0.03 14.2 0.2 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 EEA08352.1 - 0.03 14.5 0.7 10 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EEA08352.1 - 0.032 14.6 0.0 7.5 7.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.14 EEA08352.1 - 0.032 14.2 0.0 12 5.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EEA08352.1 - 0.078 13.1 0.0 5 7.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EEA08352.1 - 0.091 12.4 0.0 15 5.1 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_30 PF13604.6 EEA08352.1 - 0.16 11.7 0.0 8.4 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EEA08352.1 - 0.19 11.4 0.4 11 5.7 0.1 2.6 2 1 0 2 2 2 0 AAA domain Sgf11_N PF18519.1 EEA08352.1 - 0.55 9.8 3.8 0.22 11.1 0.3 2.2 2 0 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain RRM_1 PF00076.22 EEA08353.1 - 1.3e-63 210.7 1.9 5.6e-15 54.9 0.0 5.6 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EEA08353.1 - 0.012 15.8 0.0 0.5 10.6 0.0 3.0 2 0 0 2 2 2 0 BRCA1-associated protein 2 RRM_occluded PF16842.5 EEA08353.1 - 0.015 15.2 0.0 0.71 9.8 0.0 3.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif RL PF17797.1 EEA08353.1 - 0.05 13.6 0.0 2.5 8.1 0.0 3.0 2 0 0 2 2 2 0 RL domain TFIIE_beta PF02186.15 EEA08354.1 - 0.0015 18.8 0.7 0.0015 18.8 0.7 2.1 2 0 0 2 2 2 1 TFIIE beta subunit core domain SNARE_assoc PF09335.11 EEA08355.1 - 4.7e-14 52.9 5.1 4.7e-14 52.9 5.1 2.0 3 0 0 3 3 3 1 SNARE associated Golgi protein SF3b1 PF08920.10 EEA08356.1 - 9.6e-21 74.5 0.5 3.4e-20 72.7 0.5 1.9 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT PF02985.22 EEA08356.1 - 3.3e-16 58.0 2.8 0.022 15.0 0.0 9.3 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EEA08356.1 - 3e-11 43.6 0.7 0.39 11.1 0.0 7.7 5 2 2 8 8 8 2 HEAT repeats Cnd1 PF12717.7 EEA08356.1 - 3.4e-09 37.0 7.1 0.25 11.4 0.1 6.9 5 2 2 7 7 7 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EEA08356.1 - 3.8e-09 36.8 0.3 0.49 11.0 0.0 6.9 6 1 1 7 7 7 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EEA08356.1 - 0.00015 22.3 1.0 0.21 12.2 0.0 4.9 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region UME PF08064.13 EEA08356.1 - 0.00029 20.7 0.4 4.9 7.1 0.0 5.0 5 0 0 5 5 5 1 UME (NUC010) domain CLASP_N PF12348.8 EEA08356.1 - 0.0026 17.3 2.5 3.6 7.1 0.5 4.1 4 1 0 4 4 4 1 CLASP N terminal UPF0220 PF05255.11 EEA08356.1 - 0.16 11.5 0.1 0.34 10.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) PC_rep PF01851.22 EEA08356.1 - 0.19 12.3 1.0 15 6.2 1.6 2.9 2 0 0 2 2 2 0 Proteasome/cyclosome repeat Tubulin PF00091.25 EEA08357.1 - 1.9e-68 230.6 0.0 3.9e-68 229.5 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EEA08357.1 - 1.9e-40 137.9 0.1 3e-40 137.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EEA08357.1 - 0.00012 22.4 0.0 0.00029 21.1 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EEA08357.1 - 0.038 13.7 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 EEA08357.1 - 0.18 11.0 0.0 0.34 10.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Torus PF16131.5 EEA08358.1 - 9.8e-31 106.7 2.1 2.6e-30 105.3 0.3 2.1 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 EEA08358.1 - 2.6e-06 27.1 0.0 9.1e-06 25.4 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 EEA08358.1 - 0.028 14.2 10.6 0.053 13.3 10.6 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger zf-CCCH PF00642.24 EEA08358.1 - 0.96 9.4 7.9 1.8 8.6 7.9 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EEA08358.1 - 2.3 8.4 8.5 4.4 7.5 8.5 1.5 1 0 0 1 1 1 0 Zinc finger domain zf-B_box PF00643.24 EEA08360.1 - 4.3e-05 23.6 30.0 0.0002 21.4 8.8 3.3 3 0 0 3 3 3 2 B-box zinc finger PhnA PF03831.14 EEA08360.1 - 0.54 10.2 3.6 1.3 9.0 1.6 2.5 2 0 0 2 2 2 0 PhnA domain Rad51 PF08423.11 EEA08361.1 - 0.0023 17.3 0.0 0.019 14.2 0.0 2.1 1 1 0 1 1 1 1 Rad51 Catalase_C PF18011.1 EEA08361.1 - 0.015 14.9 0.1 0.028 14.1 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases CPW_WPC PF09717.10 EEA08362.1 - 0.074 14.0 0.9 0.074 14.0 0.9 4.7 3 1 2 5 5 5 0 Plasmodium falciparum domain of unknown function (CPW_WPC) cEGF PF12662.7 EEA08362.1 - 0.52 10.3 5.6 11 6.1 0.0 3.6 3 0 0 3 3 3 0 Complement Clr-like EGF-like DEAD PF00270.29 EEA08363.1 - 6.2e-45 153.1 0.1 1.7e-44 151.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08363.1 - 3.1e-27 95.1 0.4 3.7e-25 88.4 0.2 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08363.1 - 0.00012 22.1 0.0 0.00032 20.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EEA08363.1 - 0.0002 20.3 1.1 0.17 10.6 0.1 2.9 2 1 1 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 EEA08363.1 - 0.079 13.2 1.9 0.79 10.0 0.1 3.2 4 0 0 4 4 4 0 AAA domain HIT PF01230.23 EEA08364.1 - 7.4e-24 84.3 0.0 9.7e-24 84.0 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EEA08364.1 - 7.7e-07 29.6 0.0 1.2e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding MAPKK1_Int PF08923.10 EEA08365.1 - 0.0017 18.1 1.0 0.0023 17.7 1.0 1.2 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting Peptidase_S8 PF00082.22 EEA08366.1 - 6.9e-47 160.1 1.3 1.4e-46 159.2 1.3 1.5 1 0 0 1 1 1 1 Subtilase family Aminotran_5 PF00266.19 EEA08366.1 - 0.13 11.2 0.1 0.34 9.8 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V Prp19 PF08606.11 EEA08367.1 - 3.4e-31 107.0 1.4 7.6e-31 105.9 1.4 1.7 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 EEA08367.1 - 1.1e-06 28.7 0.0 4.2e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 U-box domain ANAPC4_WD40 PF12894.7 EEA08367.1 - 0.00023 21.4 0.1 0.48 10.8 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain zf-NOSIP PF15906.5 EEA08367.1 - 0.0071 16.5 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein WD40 PF00400.32 EEA08367.1 - 0.013 16.4 3.0 0.74 10.8 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat zf-Nse PF11789.8 EEA08367.1 - 0.013 15.3 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit SUKH_6 PF14568.6 EEA08367.1 - 0.13 12.7 1.2 6.2 7.3 0.0 3.0 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall DEAD PF00270.29 EEA08368.1 - 1e-46 158.9 0.0 2.2e-46 157.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EEA08368.1 - 7.7e-26 90.6 1.3 8.6e-25 87.2 0.2 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain GUCT PF08152.12 EEA08368.1 - 3.4e-12 46.5 0.0 1.3e-11 44.6 0.0 2.0 1 0 0 1 1 1 1 GUCT (NUC152) domain ResIII PF04851.15 EEA08368.1 - 1.1e-09 38.6 0.9 1.8e-09 37.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Chordopox_G2 PF05796.12 EEA08368.1 - 0.0077 15.7 0.2 0.017 14.6 0.2 1.5 1 0 0 1 1 1 1 Chordopoxvirus protein G2 CMS1 PF14617.6 EEA08368.1 - 0.015 14.6 0.3 0.037 13.4 0.3 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Tropomyosin PF00261.20 EEA08369.1 - 0.0017 17.7 6.6 0.0017 17.7 6.6 3.7 1 1 1 3 3 3 2 Tropomyosin JAKMIP_CC3 PF16034.5 EEA08369.1 - 0.0063 16.5 9.8 0.0063 16.5 9.8 3.9 1 1 3 4 4 3 1 JAKMIP CC3 domain Tropomyosin_1 PF12718.7 EEA08369.1 - 0.042 14.0 41.3 0.019 15.1 21.8 3.0 2 0 0 2 2 2 0 Tropomyosin like Spc7 PF08317.11 EEA08369.1 - 0.28 10.0 42.9 0.47 9.3 13.5 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein HAP1_N PF04849.13 EEA08369.1 - 0.3 10.3 40.4 0.28 10.3 6.5 3.7 1 1 1 3 3 3 0 HAP1 N-terminal conserved region ERM PF00769.19 EEA08369.1 - 0.84 9.4 35.1 0.011 15.6 12.1 2.7 3 0 0 3 3 3 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 EEA08369.1 - 1 9.4 31.6 0.86 9.6 4.4 4.8 3 2 2 5 5 5 0 Protein of unknown function (DUF1664) CALCOCO1 PF07888.11 EEA08369.1 - 2 7.2 36.9 0.2 10.5 10.0 2.4 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like SlyX PF04102.12 EEA08369.1 - 2.3 8.9 34.5 0.35 11.5 2.4 6.1 4 2 2 6 6 6 0 SlyX HMMR_N PF15905.5 EEA08369.1 - 2.6 7.4 56.4 0.065 12.7 13.5 3.5 3 1 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal YabA PF06156.13 EEA08369.1 - 2.7 8.7 38.9 0.75 10.5 5.9 4.5 2 1 2 4 4 4 0 Initiation control protein YabA DUF4407 PF14362.6 EEA08369.1 - 3.1 7.1 24.2 0.92 8.8 5.4 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 EEA08369.1 - 6.1 7.0 51.6 2.2 8.5 13.3 3.8 2 1 0 3 3 3 0 Autophagy protein 16 (ATG16) ARS2 PF04959.13 EEA08369.1 - 9.4 6.6 12.8 0.25 11.7 4.5 2.4 2 1 0 2 2 2 0 Arsenite-resistance protein 2 Peptidase_C1 PF00112.23 EEA08370.1 - 3.2e-67 226.8 2.3 3.2e-67 226.8 2.3 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EEA08370.1 - 1.1e-12 48.2 9.5 1.1e-12 48.2 9.5 2.5 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EEA08370.1 - 4.8e-09 35.5 5.2 2e-05 23.6 0.1 2.6 2 1 0 2 2 2 2 Peptidase C1-like family ABC2_membrane_3 PF12698.7 EEA08370.1 - 0.031 13.4 0.2 0.036 13.2 0.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein CotJB PF12652.7 EEA08370.1 - 0.075 13.3 0.3 7.4 6.9 0.7 2.7 2 0 0 2 2 2 0 CotJB protein O-antigen_lig PF13425.6 EEA08370.1 - 0.19 10.5 2.4 0.31 9.8 2.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein JmjN PF02375.17 EEA08370.1 - 1.4 8.9 4.3 20 5.2 0.7 3.4 3 0 0 3 3 3 0 jmjN domain DUF5345 PF17280.2 EEA08370.1 - 6.8 6.7 6.5 1.1 9.3 0.2 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5345) CRT-like PF08627.10 EEA08371.1 - 4.1e-128 427.1 28.5 4.9e-128 426.8 28.5 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EEA08371.1 - 4.1e-05 23.0 26.1 0.00057 19.2 26.1 2.0 1 1 0 1 1 1 1 UAA transporter family SLC35F PF06027.12 EEA08371.1 - 7.7e-05 22.3 14.5 9.3e-05 22.1 9.3 2.5 2 1 0 2 2 2 1 Solute carrier family 35 EamA PF00892.20 EEA08371.1 - 0.0002 21.6 14.9 0.0002 21.6 14.9 3.4 3 1 1 4 4 4 2 EamA-like transporter family DUF2976 PF11190.8 EEA08371.1 - 0.091 12.6 2.6 3.2 7.6 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) Acylphosphatase PF00708.18 EEA08372.1 - 7.6e-23 80.7 0.0 8.3e-23 80.6 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase Baculo_11_kDa PF06143.11 EEA08372.1 - 0.13 11.8 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family zf-CCCH_2 PF14608.6 EEA08373.1 - 0.041 14.4 17.5 0.058 13.9 3.2 4.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger AIM3 PF17096.5 EEA08373.1 - 0.085 13.8 5.1 0.097 13.6 0.4 2.6 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 zf_CCCH_4 PF18345.1 EEA08373.1 - 0.2 11.7 9.7 2.7 8.2 0.0 3.6 3 0 0 3 3 3 0 Zinc finger domain Jnk-SapK_ap_N PF09744.9 EEA08374.1 - 0.0031 17.8 1.2 0.0069 16.6 1.2 1.5 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 Voltage_CLC PF00654.20 EEA08374.1 - 0.016 14.5 0.2 0.016 14.5 0.2 1.7 3 0 0 3 3 3 0 Voltage gated chloride channel Phage_holin_2_2 PF10746.9 EEA08374.1 - 0.025 14.2 0.5 0.063 13.0 0.5 1.6 1 0 0 1 1 1 0 Phage holin T7 family, holin superfamily II YMF19 PF02326.15 EEA08375.1 - 0.045 14.5 0.7 0.045 14.5 0.7 2.0 1 1 1 2 2 2 0 Plant ATP synthase F0 Viral_Beta_CD PF04530.12 EEA08375.1 - 0.098 13.0 0.5 0.14 12.4 0.1 1.5 1 1 1 2 2 2 0 Viral Beta C/D like family Adaptin_N PF01602.20 EEA08376.1 - 8.1e-48 163.3 20.7 8.1e-48 163.3 20.7 2.1 2 0 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 EEA08376.1 - 2.9e-19 69.7 0.3 2.9e-19 69.7 0.3 3.4 3 2 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EEA08376.1 - 3.6e-06 27.0 0.3 1.2e-05 25.3 0.3 1.9 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain NLRC4_HD2 PF17776.1 EEA08376.1 - 0.0042 17.6 0.7 1.2 9.7 0.0 3.2 2 1 0 2 2 2 1 NLRC4 helical domain HD2 HEAT PF02985.22 EEA08376.1 - 0.0069 16.6 0.0 3.4 8.2 0.1 3.2 2 0 0 2 2 2 1 HEAT repeat DUF4239 PF14023.6 EEA08377.1 - 0.56 9.9 2.9 5.4 6.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4239) Pkinase PF00069.25 EEA08379.1 - 2e-35 122.4 2.0 2.2e-18 66.6 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08379.1 - 8.6e-19 67.8 0.1 2.8e-08 33.4 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EEA08379.1 - 5.1e-06 26.0 0.0 0.017 14.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pox_ser-thr_kin PF05445.11 EEA08379.1 - 0.00027 20.0 0.6 0.00044 19.3 0.6 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Abhydrolase_6 PF12697.7 EEA08380.1 - 6.3e-06 26.9 0.0 8.3e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EEA08380.1 - 0.00011 21.6 0.0 0.0013 18.1 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EEA08380.1 - 0.0027 17.2 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Cpn60_TCP1 PF00118.24 EEA08381.1 - 1e-83 281.7 7.8 1.5e-83 281.1 7.8 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MukB_hinge PF16330.5 EEA08381.1 - 0.00057 19.6 0.1 0.044 13.5 0.1 3.0 3 0 0 3 3 3 1 MukB hinge domain DAP3 PF10236.9 EEA08381.1 - 0.12 11.6 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF1380 PF07128.12 EEA08381.1 - 0.15 12.2 0.0 25 5.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1380) Hydrolase_4 PF12146.8 EEA08382.1 - 1.7e-10 40.6 0.0 2.5e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EEA08382.1 - 5.5e-06 26.2 0.0 2.4e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EEA08382.1 - 0.00025 20.6 0.0 0.0019 17.7 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EEA08382.1 - 0.00073 19.4 0.3 0.008 16.0 0.3 2.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Say1_Mug180 PF10340.9 EEA08382.1 - 0.0008 18.4 0.0 0.0014 17.6 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 EEA08382.1 - 0.00096 19.8 0.0 0.0013 19.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EEA08382.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 EEA08382.1 - 0.083 12.5 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 EEA08382.1 - 0.22 11.1 0.0 0.42 10.1 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EEA08382.1 - 0.26 11.1 0.0 0.52 10.1 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold HEAT PF02985.22 EEA08383.1 - 5.2e-13 48.0 10.5 0.32 11.4 0.0 9.3 10 0 0 10 10 10 4 HEAT repeat Cnd1 PF12717.7 EEA08383.1 - 9.6e-07 29.0 3.4 0.14 12.2 0.1 5.1 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EEA08383.1 - 6.7e-05 23.2 0.0 7.9 7.0 0.0 6.1 6 1 0 7 7 7 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EEA08383.1 - 0.0063 17.1 4.0 0.5 11.0 0.3 4.7 3 1 3 6 6 6 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EEA08383.1 - 0.014 15.0 0.0 0.14 11.7 0.0 2.6 3 0 0 3 3 3 0 CLASP N terminal HEAT_EZ PF13513.6 EEA08383.1 - 0.21 12.1 0.0 1.5e+02 3.0 0.0 4.3 4 1 1 5 5 5 0 HEAT-like repeat WD40 PF00400.32 EEA08384.1 - 4.8e-09 36.7 4.8 0.0018 19.1 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat CS PF04969.16 EEA08385.1 - 0.018 16.1 2.4 0.094 13.8 2.4 2.1 1 1 0 1 1 1 0 CS domain Tfb4 PF03850.14 EEA08386.1 - 5.2e-26 91.8 7.6 7.2e-26 91.3 7.6 1.3 1 0 0 1 1 1 1 Transcription factor Tfb4 FHA PF00498.26 EEA08386.1 - 0.069 13.5 2.7 2 8.8 0.0 3.1 3 1 0 3 3 3 0 FHA domain DUF5553 PF17707.1 EEA08386.1 - 0.1 12.0 2.8 0.11 11.9 0.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5553) Pkinase PF00069.25 EEA08388.1 - 8.4e-33 113.9 0.0 1.4e-32 113.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08388.1 - 3.2e-14 52.8 0.0 6.1e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA08388.1 - 0.00073 18.9 0.1 0.0053 16.1 0.0 2.2 3 0 0 3 3 3 1 Kinase-like RIO1 PF01163.22 EEA08388.1 - 0.0063 16.1 0.1 0.097 12.3 0.0 2.3 2 0 0 2 2 2 1 RIO1 family Ribophorin_I PF04597.14 EEA08389.1 - 1.3e-88 298.1 12.2 1.5e-88 297.9 12.2 1.0 1 0 0 1 1 1 1 Ribophorin I Cpn60_TCP1 PF00118.24 EEA08390.1 - 8.1e-144 479.9 5.7 9.3e-144 479.7 5.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SGT1 PF07093.11 EEA08391.1 - 1.2e-31 109.9 12.4 2.9e-31 108.6 0.3 2.1 1 1 0 2 2 2 2 SGT1 protein V-SNARE PF05008.15 EEA08391.1 - 0.6 10.5 2.6 0.69 10.3 0.4 2.1 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus FlaG PF03646.15 EEA08391.1 - 3.4 7.9 5.8 37 4.6 0.1 3.1 3 0 0 3 3 3 0 FlaG protein DNA_pol_B PF00136.21 EEA08392.1 - 2.6e-53 181.4 2.3 6.7e-29 100.9 0.1 2.9 2 1 1 3 3 3 2 DNA polymerase family B zf-C4pol PF14260.6 EEA08392.1 - 0.0038 17.6 14.0 0.0045 17.4 9.0 2.7 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta LAGLIDADG_2 PF03161.13 EEA08393.1 - 0.0058 16.7 1.7 0.014 15.4 0.4 2.3 2 0 0 2 2 2 1 LAGLIDADG DNA endonuclease family Mannosyl_trans2 PF04188.13 EEA08394.1 - 2.3e-31 109.6 53.8 5.6e-30 105.0 53.8 2.2 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) DUF5411 PF17424.2 EEA08395.1 - 0.0086 16.1 0.5 0.013 15.5 0.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5411) zf-HC5HC2H_2 PF13832.6 EEA08397.1 - 3.2e-08 33.7 27.0 4.1e-08 33.4 11.6 3.7 2 2 3 5 5 5 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA08397.1 - 1.6e-06 28.2 14.5 1.6e-06 28.2 14.5 4.0 2 2 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EEA08397.1 - 1e-05 25.0 4.3 1e-05 25.0 4.3 4.0 4 2 0 4 4 4 1 PHD-finger PHD PF00628.29 EEA08397.1 - 2.4e-05 24.1 4.2 2.4e-05 24.1 4.2 4.5 4 1 1 5 5 5 1 PHD-finger C1_1 PF00130.22 EEA08397.1 - 0.00014 21.7 0.6 0.00014 21.7 0.6 4.1 3 1 1 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 EEA08397.1 - 0.03 14.7 9.4 0.03 14.7 9.4 4.6 5 2 1 6 6 6 0 Ring finger domain Yippee-Mis18 PF03226.14 EEA08397.1 - 1.3 9.3 19.2 4.6 7.5 4.7 2.8 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Met_10 PF02475.16 EEA08398.1 - 1e-43 149.5 0.2 1.8e-43 148.6 0.0 1.5 2 0 0 2 2 2 1 Met-10+ like-protein MTS PF05175.14 EEA08398.1 - 0.0001 21.9 0.0 0.0002 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EEA08398.1 - 0.0019 18.9 0.0 0.0094 16.6 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EEA08398.1 - 0.002 17.9 0.2 0.0096 15.7 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain DNA_methylase PF00145.17 EEA08398.1 - 0.0039 16.6 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase PrmA PF06325.13 EEA08398.1 - 0.0057 16.1 0.0 0.0094 15.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DUF4467 PF14729.6 EEA08398.1 - 0.016 15.6 0.1 0.049 14.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function with cystatin-like fold (DUF4467) tRNA_U5-meth_tr PF05958.11 EEA08398.1 - 0.02 13.9 1.5 0.38 9.7 0.1 2.2 2 0 0 2 2 2 0 tRNA (Uracil-5-)-methyltransferase FmrO PF07091.11 EEA08398.1 - 0.026 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_12 PF08242.12 EEA08398.1 - 0.093 13.5 0.0 0.86 10.4 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Lectin_leg-like PF03388.13 EEA08399.1 - 1.9e-18 66.6 0.0 4.4e-18 65.5 0.0 1.5 1 1 0 1 1 1 1 Legume-like lectin family COG5 PF10392.9 EEA08399.1 - 0.056 13.6 4.2 0.13 12.5 3.7 1.8 1 1 0 1 1 1 0 Golgi transport complex subunit 5 DUF2225 PF09986.9 EEA08399.1 - 0.14 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) DTC PF18102.1 EEA08400.1 - 1.6e-26 93.0 0.1 6.1e-26 91.1 0.1 2.0 1 1 0 1 1 1 1 Deltex C-terminal domain WWE PF02825.20 EEA08400.1 - 2e-12 47.5 13.5 1.8e-07 31.7 1.5 3.5 2 1 1 3 3 3 2 WWE domain zf-RING_2 PF13639.6 EEA08400.1 - 7.9e-06 26.1 11.4 2.3e-05 24.6 11.4 1.9 1 0 0 1 1 1 1 Ring finger domain zf-Nse PF11789.8 EEA08400.1 - 0.0025 17.6 6.2 0.0065 16.3 6.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 EEA08400.1 - 0.017 15.0 12.6 0.035 14.0 12.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA08400.1 - 0.054 13.6 4.9 0.16 12.0 4.9 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EEA08400.1 - 0.16 11.8 17.6 0.024 14.5 13.3 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA08400.1 - 0.17 11.5 7.8 0.5 10.0 7.8 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EEA08400.1 - 0.37 11.1 12.9 0.041 14.2 8.1 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EEA08400.1 - 2.5 7.9 16.2 0.13 12.1 10.2 2.1 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 EEA08400.1 - 3.7 7.5 9.4 8.9 6.3 9.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EEA08400.1 - 5.3 7.1 11.2 10 6.1 11.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain CAMSAP_CKK PF08683.11 EEA08401.1 - 3.3e-15 56.3 0.0 7.4e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated DUF1091 PF06477.13 EEA08402.1 - 0.052 14.0 2.9 0.22 12.0 2.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) zf-RING_9 PF13901.6 EEA08405.1 - 1.3e-11 44.9 9.9 8.1e-10 39.0 1.9 2.9 1 1 1 2 2 2 2 Putative zinc-RING and/or ribbon CheR_N PF03705.15 EEA08405.1 - 0.093 12.5 0.1 0.34 10.7 0.1 2.0 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain Enkurin PF13864.6 EEA08405.1 - 0.15 12.5 4.7 0.16 12.5 1.4 2.5 2 0 0 2 2 2 0 Calmodulin-binding Peptidase_C14 PF00656.22 EEA08406.1 - 0.00011 22.2 0.1 0.0056 16.7 0.0 2.3 2 0 0 2 2 2 1 Caspase domain Siah-Interact_N PF09032.11 EEA08406.1 - 0.036 14.4 1.8 0.051 13.9 0.4 1.9 2 0 0 2 2 2 0 Siah interacting protein, N terminal HIP1_clath_bdg PF16515.5 EEA08406.1 - 0.053 14.1 0.6 0.11 13.2 0.6 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMF_DNA_bd PF12329.8 EEA08406.1 - 0.057 13.4 1.4 0.12 12.4 1.4 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding COMP PF11598.8 EEA08406.1 - 0.13 12.7 0.4 0.35 11.4 0.4 1.6 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein IFP_35_N PF07334.13 EEA08406.1 - 0.91 9.6 5.4 0.1 12.6 0.6 2.0 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Pkinase PF00069.25 EEA08407.1 - 1.1e-64 218.4 0.1 1.6e-63 214.5 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08407.1 - 1.6e-34 119.3 0.0 2.6e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA08407.1 - 4.6e-06 26.2 0.0 1.5e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EEA08407.1 - 0.00068 18.5 0.0 0.0014 17.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EEA08407.1 - 0.0017 18.0 0.1 0.97 9.0 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 SH2_2 PF14633.6 EEA08408.1 - 1.2e-30 106.6 0.2 2.4e-30 105.6 0.2 1.5 1 0 0 1 1 1 1 SH2 domain HHH_7 PF14635.6 EEA08408.1 - 3.1e-09 37.1 0.6 1.6e-08 34.8 0.2 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EEA08408.1 - 2.6e-06 27.8 0.1 1e-05 25.9 0.1 2.1 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 EEA08408.1 - 3.8e-05 24.2 19.2 3.8e-05 24.2 19.2 6.1 5 1 1 6 6 6 1 Acidic N-terminal SPT6 YqgF PF14639.6 EEA08408.1 - 0.0012 18.6 0.1 0.0049 16.7 0.0 2.1 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 ABC_tran PF00005.27 EEA08409.1 - 3e-48 163.8 3.0 5.3e-24 85.3 0.0 3.3 4 0 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EEA08409.1 - 1.5e-20 73.0 0.6 1.5e-20 73.0 0.6 2.4 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EEA08409.1 - 6.3e-17 62.3 19.8 4.2e-06 26.8 0.6 5.2 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA08409.1 - 3.4e-11 43.0 5.1 0.0011 18.4 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EEA08409.1 - 3.3e-08 33.1 2.9 0.00045 19.9 0.1 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EEA08409.1 - 2.5e-05 24.5 0.5 0.14 12.4 0.2 4.2 3 1 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EEA08409.1 - 3.9e-05 24.2 0.1 3.9e-05 24.2 0.1 4.7 3 1 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 EEA08409.1 - 0.0002 21.3 0.2 1.1 9.1 0.0 2.8 2 1 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EEA08409.1 - 0.00026 21.5 2.6 0.37 11.4 0.0 3.9 4 0 0 4 4 3 1 AAA domain NACHT PF05729.12 EEA08409.1 - 0.00082 19.3 0.5 0.76 9.7 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 EEA08409.1 - 0.00083 19.1 0.0 0.65 9.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EEA08409.1 - 0.00089 19.4 0.1 0.96 9.6 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EEA08409.1 - 0.0018 18.7 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EEA08409.1 - 0.002 18.2 0.4 1.4 9.0 0.1 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EEA08409.1 - 0.0029 17.0 0.3 0.012 15.0 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_28 PF13521.6 EEA08409.1 - 0.0033 17.7 0.6 1.5 9.0 0.8 2.6 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EEA08409.1 - 0.0035 16.6 0.2 2.5 7.2 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain DUF3584 PF12128.8 EEA08409.1 - 0.0046 14.5 0.1 0.0046 14.5 0.1 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3584) AAA_15 PF13175.6 EEA08409.1 - 0.005 16.6 0.4 0.005 16.6 0.4 5.2 2 1 1 4 4 4 1 AAA ATPase domain T2SSE PF00437.20 EEA08409.1 - 0.011 14.8 0.0 0.17 10.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_14 PF13173.6 EEA08409.1 - 0.012 15.6 3.6 11 6.0 0.0 4.3 3 1 1 4 4 4 0 AAA domain NTPase_1 PF03266.15 EEA08409.1 - 0.012 15.5 0.3 1.4 8.8 0.1 2.7 2 0 0 2 2 2 0 NTPase RNA_helicase PF00910.22 EEA08409.1 - 0.016 15.6 0.1 11 6.5 0.0 3.1 3 0 0 3 3 2 0 RNA helicase Dynamin_N PF00350.23 EEA08409.1 - 0.022 14.8 0.0 2.8 7.9 0.0 2.9 2 0 0 2 2 2 0 Dynamin family AAA_19 PF13245.6 EEA08409.1 - 0.04 14.3 0.0 0.55 10.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EEA08409.1 - 0.041 14.1 0.0 11 6.3 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EEA08409.1 - 0.059 12.9 0.0 2.7 7.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 EEA08409.1 - 0.072 13.2 8.6 7 6.7 0.1 4.0 4 0 0 4 4 4 0 Helicase HerA, central domain AAA PF00004.29 EEA08409.1 - 0.11 12.9 0.3 12 6.4 0.1 3.3 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EEA08409.1 - 0.11 12.5 0.9 4.1 7.4 0.0 2.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MobB PF03205.14 EEA08409.1 - 0.11 12.4 0.1 3.3 7.6 0.1 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 EEA08409.1 - 0.15 11.0 0.0 20 4.1 0.0 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_5 PF07728.14 EEA08409.1 - 0.16 11.9 0.3 72 3.4 0.1 3.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Baculo_FP PF03258.14 EEA08409.1 - 0.28 11.3 6.2 0.37 10.9 0.2 2.8 3 0 0 3 3 2 0 Baculovirus FP protein DUF1672 PF07901.11 EEA08409.1 - 2.1 7.6 9.9 0.54 9.5 5.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1672) Formyl_trans_C PF02911.18 EEA08411.1 - 0.24 11.7 2.0 1.4 9.2 0.0 3.2 4 0 0 4 4 4 0 Formyl transferase, C-terminal domain AP2 PF00847.20 EEA08413.1 - 2e-44 149.6 11.1 1.8e-14 53.7 0.6 4.6 4 0 0 4 4 4 4 AP2 domain CCSMST1 PF15013.6 EEA08413.1 - 0.13 12.4 0.1 0.4 10.9 0.1 1.8 1 0 0 1 1 1 0 CCSMST1 family BLOC1_2 PF10046.9 EEA08414.1 - 0.59 10.5 5.0 1.7 9.0 0.2 3.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ABC2_membrane PF01061.24 EEA08416.1 - 7e-32 110.5 25.9 1.5e-31 109.5 25.9 1.5 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EEA08416.1 - 9.6e-22 78.0 0.0 1.9e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EEA08416.1 - 6.2e-05 22.5 1.4 0.037 13.4 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EEA08416.1 - 6.5e-05 22.2 35.5 6.5e-05 22.2 35.5 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EEA08416.1 - 9.6e-05 22.3 3.2 0.058 13.2 0.0 2.5 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EEA08416.1 - 0.00086 19.2 0.5 0.0026 17.7 0.2 1.9 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EEA08416.1 - 0.0023 18.0 0.8 0.0059 16.7 0.8 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EEA08416.1 - 0.0025 18.3 0.0 0.0053 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EEA08416.1 - 0.0042 16.8 0.2 0.013 15.2 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EEA08416.1 - 0.012 16.0 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 EEA08416.1 - 0.016 14.2 0.1 0.028 13.4 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EEA08416.1 - 0.045 13.8 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 Dynamin family NTPase_1 PF03266.15 EEA08416.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.6 EEA08416.1 - 0.15 12.3 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EEA08416.1 - 0.21 10.6 0.5 0.35 9.9 0.5 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Ubiquitin_2 PF14560.6 EEA08419.1 - 0.065 13.7 1.0 1.1 9.8 0.0 2.8 2 0 0 2 2 2 0 Ubiquitin-like domain ABC_tran_CTD PF16326.5 EEA08419.1 - 0.077 13.3 3.6 0.62 10.3 0.4 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4208 PF13907.6 EEA08419.1 - 4 7.9 7.3 6 7.4 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4208) DUF3744 PF12558.8 EEA08420.1 - 2.1 9.2 6.3 67 4.4 0.2 4.1 2 1 1 3 3 3 0 ATP-binding cassette cobalt transporter Trypan_PARP PF05887.11 EEA08421.1 - 2.9e-09 37.0 44.5 2.9e-09 37.0 44.5 3.9 2 1 1 3 3 3 2 Procyclic acidic repetitive protein (PARP) Zn_ribbon_2 PF12674.7 EEA08422.1 - 0.96 10.1 4.3 0.51 11.0 0.6 2.5 2 0 0 2 2 2 0 Putative zinc ribbon domain BUD22 PF09073.10 EEA08424.1 - 0.15 11.4 49.3 0.22 10.8 49.3 1.2 1 0 0 1 1 1 0 BUD22 DUF3309 PF11752.8 EEA08424.1 - 0.76 9.9 6.9 1.4 9.0 3.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3309) Hid1 PF12722.7 EEA08424.1 - 5.2 5.1 36.5 8.8 4.3 36.5 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ABC_tran PF00005.27 EEA08426.1 - 4.5e-28 98.5 0.0 7e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EEA08426.1 - 2e-25 89.5 33.6 3.7e-25 88.6 33.6 1.4 1 0 0 1 1 1 1 ABC-2 type transporter AAA_16 PF13191.6 EEA08426.1 - 8.7e-06 26.2 0.0 1.6e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EEA08426.1 - 1.5e-05 25.0 12.2 0.00042 20.2 0.4 3.0 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EEA08426.1 - 1.5e-05 24.5 0.0 0.012 15.1 0.0 2.8 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EEA08426.1 - 2e-05 23.9 37.3 2e-05 23.9 37.3 2.1 1 1 1 2 2 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EEA08426.1 - 0.00062 19.7 0.1 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_35 PF14516.6 EEA08426.1 - 0.0023 16.8 0.0 0.0037 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_23 PF13476.6 EEA08426.1 - 0.014 16.0 0.7 0.026 15.0 0.1 1.7 2 0 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 EEA08426.1 - 0.014 15.3 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EEA08426.1 - 0.016 14.9 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EEA08426.1 - 0.058 13.3 0.1 0.097 12.6 0.1 1.3 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 EEA08426.1 - 0.073 12.8 0.1 0.2 11.4 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EEA08426.1 - 0.075 13.5 0.1 0.22 12.0 0.0 1.9 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EEA08426.1 - 0.083 13.0 0.3 0.17 12.0 0.3 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase T2SSE PF00437.20 EEA08426.1 - 0.085 11.9 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein KAP_NTPase PF07693.14 EEA08426.1 - 0.096 11.9 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_28 PF13521.6 EEA08426.1 - 0.15 12.3 0.2 0.24 11.7 0.2 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EEA08426.1 - 0.16 12.5 0.0 0.34 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EEA08426.1 - 0.18 12.1 0.1 0.47 10.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain ATG19_autophagy PF12744.7 EEA08427.1 - 0.1 11.8 3.3 4 6.6 0.8 2.1 2 0 0 2 2 2 0 Autophagy protein Atg19, Atg8-binding NifT PF06988.11 EEA08427.1 - 0.12 12.2 0.1 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 NifT/FixU protein ATP-gua_Ptrans PF00217.19 EEA08428.1 - 4.1e-77 258.4 0.0 5.4e-77 258.0 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 EEA08428.1 - 9.8e-20 70.7 0.1 2.9e-19 69.2 0.1 1.8 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Patched PF02460.18 EEA08429.1 - 1.5e-100 337.5 1.8 3.4e-100 336.4 1.8 1.6 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EEA08429.1 - 2.9e-19 69.4 9.3 2.9e-19 69.4 9.3 2.4 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 EEA08429.1 - 0.001 16.9 5.1 0.0015 16.3 5.1 1.1 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family DUF720 PF05302.11 EEA08429.1 - 0.056 13.3 0.5 1.8 8.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF720) Pkinase PF00069.25 EEA08430.1 - 1.4e-61 208.2 0.3 2.5e-54 184.4 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08430.1 - 1.3e-27 96.7 0.3 3.3e-23 82.3 0.2 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EEA08430.1 - 0.0078 15.2 4.6 0.047 12.6 4.6 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Sybindin PF04099.12 EEA08431.1 - 3.2e-43 147.1 0.7 3.6e-43 146.9 0.7 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EEA08431.1 - 5e-07 29.9 0.1 6.7e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Pyr_redox_2 PF07992.14 EEA08432.1 - 1.4e-53 182.0 0.0 1.7e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EEA08432.1 - 1.5e-20 73.5 0.0 1.1e-19 70.7 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EEA08432.1 - 7.2e-16 58.5 2.4 2e-10 41.1 0.1 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EEA08432.1 - 3.8e-10 39.5 0.3 1.1e-06 28.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EEA08432.1 - 1.2e-07 31.2 1.7 9.7e-07 28.2 1.9 2.2 3 0 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.7 EEA08432.1 - 5.9e-06 25.9 0.7 8.7e-06 25.3 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EEA08432.1 - 1.1e-05 24.9 0.0 0.00038 19.8 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EEA08432.1 - 1.4e-05 24.0 0.3 2.9e-05 23.0 0.3 1.6 1 1 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EEA08432.1 - 2.2e-05 23.7 2.0 2.4e-05 23.6 0.9 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EEA08432.1 - 0.00071 18.9 0.3 0.0021 17.3 0.1 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EEA08432.1 - 0.0013 19.0 4.0 0.002 18.3 0.4 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EEA08432.1 - 0.008 15.5 1.9 1.6 7.9 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EEA08432.1 - 0.013 15.1 6.1 0.028 14.0 1.1 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase PRCC PF10253.9 EEA08433.1 - 2.6e-05 25.1 4.3 3.6e-05 24.7 4.3 1.3 1 1 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Maf PF02545.14 EEA08434.1 - 7.8e-33 113.7 0.1 9.4e-33 113.4 0.1 1.0 1 0 0 1 1 1 1 Maf-like protein GIY-YIG PF01541.24 EEA08435.1 - 2.1e-11 43.9 0.1 5.2e-11 42.7 0.1 1.7 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-RING_2 PF13639.6 EEA08435.1 - 0.0073 16.6 5.9 0.0073 16.6 5.9 2.8 2 0 0 2 2 2 1 Ring finger domain T5orf172 PF10544.9 EEA08435.1 - 0.046 14.3 0.1 0.62 10.6 0.0 2.5 2 0 0 2 2 2 0 T5orf172 domain Peptidase_M16 PF00675.20 EEA08436.1 - 2.1e-25 89.5 0.0 1e-24 87.2 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA08436.1 - 8e-12 45.5 0.8 6.8e-08 32.7 0.0 3.6 4 0 0 4 4 4 2 Peptidase M16 inactive domain Ribosomal_S6e PF01092.19 EEA08437.1 - 2e-56 189.4 0.1 3.4e-56 188.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e GCFC PF07842.12 EEA08438.1 - 6e-18 65.4 6.3 6e-18 65.4 6.3 2.3 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EEA08438.1 - 1.3e-06 28.2 3.2 2.3e-06 27.4 3.2 1.4 1 0 0 1 1 1 1 G-patch domain LRRFIP PF09738.9 EEA08438.1 - 0.49 9.8 2.4 0.82 9.1 2.4 1.3 1 0 0 1 1 1 0 LRRFIP family Hydrolase PF00702.26 EEA08439.1 - 2.1e-16 60.9 0.0 2e-07 31.5 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EEA08439.1 - 1.1e-15 57.6 0.0 2.7e-14 53.1 0.0 2.7 1 1 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 EEA08439.1 - 0.0015 18.5 0.0 0.0035 17.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EEA08439.1 - 0.027 14.1 0.0 0.098 12.4 0.0 1.9 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Annexin PF00191.20 EEA08440.1 - 0.0097 16.0 0.2 0.032 14.3 0.2 2.0 1 0 0 1 1 1 1 Annexin MIR PF02815.19 EEA08440.1 - 0.045 13.6 2.5 0.17 11.8 2.5 2.0 1 0 0 1 1 1 0 MIR domain FliJ PF02050.16 EEA08441.1 - 0.019 15.2 2.4 0.019 15.2 2.4 2.4 1 1 1 3 3 3 0 Flagellar FliJ protein DUF4349 PF14257.6 EEA08441.1 - 0.03 13.8 0.7 0.03 13.8 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) PI_PP_I PF18363.1 EEA08441.1 - 0.043 14.0 0.8 0.15 12.3 0.3 2.2 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain FRP PF18032.1 EEA08441.1 - 0.071 13.7 0.1 0.2 12.3 0.1 1.8 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein DUF3450 PF11932.8 EEA08441.1 - 1.5 8.0 6.7 14 4.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1043 PF06295.12 EEA08441.1 - 1.7 8.6 5.3 6.4 6.8 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) JIP_LZII PF16471.5 EEA08441.1 - 2.5 8.4 15.7 14 6.0 0.7 3.7 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II DUF4200 PF13863.6 EEA08441.1 - 2.7 8.4 10.3 1.6 9.2 3.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) CENP-H PF05837.12 EEA08441.1 - 2.7 8.4 11.8 0.34 11.3 4.5 2.6 2 1 1 3 3 3 0 Centromere protein H (CENP-H) DivIC PF04977.15 EEA08441.1 - 8.3 6.3 11.2 2.9 7.7 2.5 3.1 2 1 1 3 3 3 0 Septum formation initiator Solute_trans_a PF03619.16 EEA08442.1 - 5e-80 268.8 23.9 2.1e-79 266.8 23.9 1.8 1 1 0 1 1 1 1 Organic solute transporter Ostalpha DEAD PF00270.29 EEA08443.1 - 3.8e-17 62.6 0.0 1.8e-16 60.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EEA08443.1 - 2.2e-10 40.8 4.3 8.5e-09 35.6 0.0 3.6 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EEA08443.1 - 8.8e-10 38.9 3.7 3.7e-08 33.7 0.0 3.9 2 1 1 3 3 3 1 Helicase conserved C-terminal domain PAXNEB PF05625.11 EEA08444.1 - 0.074 12.2 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 PAXNEB protein DUF872 PF05915.12 EEA08445.1 - 2e-10 40.9 0.0 2.2e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) ABC2_membrane PF01061.24 EEA08445.1 - 0.012 15.1 0.1 0.013 14.9 0.1 1.0 1 0 0 1 1 1 0 ABC-2 type transporter IMCp PF12314.8 EEA08447.1 - 2.6e-19 69.3 49.7 3.2e-14 53.0 22.7 3.3 1 1 2 3 3 3 2 Inner membrane complex protein HIF-1a_CTAD PF08778.10 EEA08447.1 - 0.00067 19.2 0.2 0.0018 17.9 0.2 1.8 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain Tim17 PF02466.19 EEA08448.1 - 6e-24 84.6 6.7 1.1e-23 83.7 6.7 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Rho_N PF07498.12 EEA08449.1 - 3.7e-07 30.0 1.1 1.2e-06 28.3 0.0 2.5 2 0 0 2 2 2 1 Rho termination factor, N-terminal domain SAP PF02037.27 EEA08449.1 - 0.0031 17.2 0.0 0.011 15.5 0.0 2.1 1 0 0 1 1 1 1 SAP domain DHR10 PF18595.1 EEA08449.1 - 0.028 14.5 5.7 0.028 14.5 5.7 2.6 2 1 0 3 3 3 0 Designed helical repeat protein 10 domain Mt_ATP-synt_B PF05405.14 EEA08449.1 - 0.43 10.2 12.0 0.083 12.5 5.9 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF1492 PF07374.11 EEA08449.1 - 0.71 10.1 9.6 0.42 10.8 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) DUF501 PF04417.12 EEA08449.1 - 0.91 9.3 5.1 0.24 11.2 1.4 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF501) V_ATPase_I PF01496.19 EEA08449.1 - 2.8 5.8 7.4 3.1 5.6 7.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pro_isomerase PF00160.21 EEA08450.1 - 2.8e-49 167.4 0.0 3.1e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EEA08450.1 - 0.041 13.9 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain DUF1091 PF06477.13 EEA08451.1 - 0.048 14.1 0.1 0.13 12.8 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1091) CHCH PF06747.13 EEA08451.1 - 0.15 12.2 0.7 0.27 11.4 0.7 1.4 1 0 0 1 1 1 0 CHCH domain UQ_con PF00179.26 EEA08452.1 - 1.6e-06 27.8 0.4 1.6e-06 27.8 0.4 1.9 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme KxDL PF10241.9 EEA08453.1 - 8.6e-05 22.7 6.3 0.0034 17.6 4.4 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein Exonuc_VII_L PF02601.15 EEA08453.1 - 0.038 13.6 4.8 0.044 13.3 4.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tic22 PF04278.12 EEA08453.1 - 0.068 12.5 0.9 0.09 12.1 0.6 1.3 1 1 0 1 1 1 0 Tic22-like family V-SNARE PF05008.15 EEA08453.1 - 0.29 11.5 12.2 0.11 12.9 9.2 1.9 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus BBP1_C PF15272.6 EEA08453.1 - 0.57 10.0 15.9 0.35 10.7 13.9 1.6 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Atg14 PF10186.9 EEA08453.1 - 1.1 8.3 12.7 1.8 7.5 12.7 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DASH_Hsk3 PF08227.11 EEA08453.1 - 1.8 9.0 5.3 18 5.8 3.3 2.9 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like bZIP_2 PF07716.15 EEA08453.1 - 4.9 7.3 9.5 1.1 9.4 1.4 3.1 2 1 1 3 3 3 0 Basic region leucine zipper ATP-synt_Eps PF04627.13 EEA08455.1 - 1.1e-10 41.3 0.2 1.7e-10 40.7 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Dopey_N PF04118.14 EEA08455.1 - 0.032 13.4 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 Dopey, N-terminal MMR_HSR1 PF01926.23 EEA08456.1 - 8.4e-13 48.4 0.2 3.7e-12 46.3 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EEA08456.1 - 2.9e-05 23.7 0.2 0.0012 18.4 0.2 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EEA08456.1 - 0.012 15.7 3.0 0.057 13.5 0.3 3.1 2 1 1 3 3 3 0 Dynamin family RsgA_GTPase PF03193.16 EEA08456.1 - 0.023 14.6 0.3 0.77 9.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase MeaB PF03308.16 EEA08456.1 - 0.14 11.1 0.0 0.31 10.0 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Stork_head PF10264.9 EEA08457.1 - 0.074 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain RMI2 PF16100.5 EEA08457.1 - 0.17 11.7 0.0 0.48 10.2 0.0 1.7 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 Rad51 PF08423.11 EEA08458.1 - 2.6e-30 105.5 0.0 8.4e-30 103.9 0.0 1.7 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 EEA08458.1 - 6.2e-08 32.3 3.4 1.7e-05 24.3 0.2 2.4 1 1 0 2 2 2 2 KaiC RecA PF00154.21 EEA08458.1 - 0.0001 21.9 0.0 0.00018 21.1 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 EEA08458.1 - 0.011 15.1 0.1 0.032 13.6 0.1 1.7 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain PAXNEB PF05625.11 EEA08458.1 - 0.047 12.8 1.8 0.3 10.2 0.0 2.1 2 0 0 2 2 2 0 PAXNEB protein AAA_25 PF13481.6 EEA08458.1 - 0.06 12.9 0.0 0.09 12.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain Phage_min_cap2 PF06152.11 EEA08459.1 - 0.021 13.8 0.1 0.033 13.1 0.1 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 DUF3336 PF11815.8 EEA08460.1 - 8.9e-31 106.4 2.3 1.9e-30 105.4 2.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EEA08460.1 - 3.6e-21 76.3 0.0 7.2e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase SNF2_N PF00176.23 EEA08461.1 - 4.6e-35 121.0 0.0 4.2e-34 117.8 0.0 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA08461.1 - 3.3e-10 40.3 0.2 1.2e-09 38.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain F-box PF00646.33 EEA08461.1 - 0.041 13.8 1.2 2.7 8.0 0.1 3.1 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EEA08461.1 - 0.068 13.1 0.5 0.36 10.7 0.1 2.4 2 0 0 2 2 2 0 F-box-like DUF771 PF05595.11 EEA08461.1 - 0.88 9.6 11.7 3 7.9 0.2 5.4 5 0 0 5 5 5 0 Domain of unknown function (DUF771) Spore_III_AB PF09548.10 EEA08462.1 - 0.83 9.7 4.4 0.77 9.8 1.0 2.6 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) KxDL PF10241.9 EEA08462.1 - 2.2 8.6 6.4 5.1 7.5 0.1 3.8 4 0 0 4 4 4 0 Uncharacterized conserved protein S1-P1_nuclease PF02265.16 EEA08463.1 - 0.0092 15.8 0.6 0.0092 15.8 0.6 2.1 1 1 1 2 2 2 1 S1/P1 Nuclease UDPGT PF00201.18 EEA08463.1 - 0.092 11.5 2.6 0.12 11.2 2.6 1.2 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase YbjQ_1 PF01906.17 EEA08463.1 - 0.096 13.3 0.1 0.32 11.7 0.0 2.0 2 1 0 2 2 2 0 Putative heavy-metal-binding SF-assemblin PF06705.11 EEA08464.1 - 1.4e-10 41.0 27.4 2.2e-10 40.3 19.2 2.3 1 1 2 3 3 3 2 SF-assemblin/beta giardin MtrG PF04210.13 EEA08464.1 - 0.077 12.9 0.9 68 3.4 0.1 3.7 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G SATase_N PF06426.14 EEA08464.1 - 0.12 12.7 3.0 0.26 11.7 0.2 2.7 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal betaPIX_CC PF16523.5 EEA08464.1 - 0.3 11.0 5.8 4.4 7.2 0.2 2.9 2 2 0 2 2 2 0 betaPIX coiled coil OmpH PF03938.14 EEA08464.1 - 0.5 10.7 7.2 0.37 11.1 3.4 2.4 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) Cbl_N PF02262.16 EEA08464.1 - 0.52 10.3 6.5 4.1 7.4 0.5 2.8 2 1 1 3 3 3 0 CBL proto-oncogene N-terminal domain 1 TINF2_N PF14973.6 EEA08464.1 - 0.63 10.4 4.1 19 5.6 1.3 2.7 2 1 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus Tup_N PF08581.10 EEA08464.1 - 0.93 9.8 10.4 0.97 9.8 0.2 3.7 2 1 1 3 3 3 0 Tup N-terminal Phage_Mu_Gam PF07352.12 EEA08464.1 - 5 7.0 10.2 1.1 9.2 2.0 3.1 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein DUF1192 PF06698.11 EEA08464.1 - 6.2 6.9 8.5 0.51 10.4 1.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF4407 PF14362.6 EEA08464.1 - 8.1 5.7 10.7 1.2e+02 1.8 10.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_2 PF07724.14 EEA08465.1 - 6.8e-36 123.9 2.3 4.5e-28 98.5 1.1 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 EEA08465.1 - 2.3e-12 47.5 4.7 3.3e-05 24.3 0.0 3.8 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EEA08465.1 - 2.1e-06 27.8 0.1 6.2e-05 23.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) MCM PF00493.23 EEA08465.1 - 2.2e-06 26.9 0.2 9.8e-05 21.6 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain AAA_22 PF13401.6 EEA08465.1 - 8.4e-05 22.9 0.0 0.00056 20.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain ClpB_D2-small PF10431.9 EEA08465.1 - 0.00016 21.7 0.8 0.0016 18.4 0.0 2.8 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein TIP49 PF06068.13 EEA08465.1 - 0.00086 18.6 1.2 0.0029 16.9 0.0 2.2 2 1 0 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 EEA08465.1 - 0.0017 18.8 0.0 0.0046 17.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 EEA08465.1 - 0.0026 17.5 0.0 0.051 13.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.6 EEA08465.1 - 0.0049 17.4 0.2 0.017 15.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 EEA08465.1 - 0.0076 15.6 0.0 0.035 13.5 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EEA08465.1 - 0.012 14.7 0.1 0.025 13.7 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 EEA08465.1 - 0.021 14.8 0.2 0.19 11.7 0.0 2.7 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EEA08465.1 - 0.03 14.1 0.0 0.077 12.7 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein RuvB_N PF05496.12 EEA08465.1 - 0.032 14.0 0.2 0.9 9.3 0.0 2.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EEA08465.1 - 0.039 13.5 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EEA08465.1 - 0.045 13.5 0.0 0.14 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EEA08465.1 - 0.084 12.8 0.8 1.8 8.4 0.0 2.5 2 0 0 2 2 2 0 NTPase Roc PF08477.13 EEA08465.1 - 0.093 13.0 0.7 0.38 11.0 0.0 2.4 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EEA08465.1 - 0.18 12.1 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EEA08465.1 - 0.42 10.6 2.9 3.9 7.4 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TraX PF05857.11 EEA08466.1 - 0.0064 16.6 0.5 0.0082 16.2 0.5 1.2 1 0 0 1 1 1 1 TraX protein DUF4481 PF14800.6 EEA08466.1 - 0.058 12.9 0.6 0.08 12.4 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) DUF1600 PF07667.11 EEA08466.1 - 0.091 13.0 6.7 0.15 12.3 6.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1600) PEN-2 PF10251.9 EEA08466.1 - 0.11 12.9 4.2 0.17 12.3 4.2 1.4 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase EF-hand_6 PF13405.6 EEA08467.1 - 4.7e-07 29.2 13.9 0.38 10.8 0.3 5.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 EEA08467.1 - 1e-06 27.9 21.3 0.087 12.4 0.7 6.0 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 EEA08467.1 - 0.0002 21.8 27.2 0.0014 19.1 1.6 5.2 4 2 1 5 5 5 3 EF-hand domain pair EF-hand_8 PF13833.6 EEA08467.1 - 0.013 15.4 14.1 2 8.3 0.8 5.8 5 0 0 5 5 5 0 EF-hand domain pair EF-hand_5 PF13202.6 EEA08467.1 - 0.016 14.7 4.9 0.052 13.1 0.6 5.5 6 0 0 6 6 6 0 EF hand RsbRD_N PF14361.6 EEA08467.1 - 1.7 9.3 6.9 9.1 7.0 0.2 3.3 3 1 1 4 4 4 0 RsbT co-antagonist protein rsbRD N-terminal domain Myb_DNA-binding PF00249.31 EEA08468.1 - 3.5e-13 49.5 0.4 5.8e-13 48.8 0.4 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EEA08468.1 - 0.00011 22.1 0.1 0.00023 21.0 0.1 1.5 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EEA08468.1 - 0.0074 16.5 0.2 0.017 15.3 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain RRM_1 PF00076.22 EEA08469.1 - 2.5e-24 84.9 0.1 3.1e-17 62.2 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EEA08469.1 - 8.1e-07 29.1 0.0 0.022 14.9 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM PF05172.13 EEA08469.1 - 9.2e-06 25.6 0.3 0.074 13.0 0.0 2.6 1 1 1 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EEA08469.1 - 0.00015 21.7 0.1 0.5 10.4 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 EEA08469.1 - 0.0057 16.6 0.1 0.098 12.6 0.1 2.2 2 0 0 2 2 2 1 RL domain V-ATPase_H_C PF11698.8 EEA08470.1 - 2.5e-37 127.6 2.3 3.9e-37 126.9 0.3 2.2 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EEA08470.1 - 3.6e-31 108.6 2.2 1.2e-30 106.9 2.2 1.7 1 1 0 1 1 1 1 V-ATPase subunit H Arm PF00514.23 EEA08470.1 - 0.0039 17.2 0.7 3.8 7.7 0.1 3.7 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EEA08470.1 - 0.014 15.7 0.1 0.17 12.3 0.0 2.7 3 0 0 3 3 3 0 HEAT repeats EF1_GNE PF00736.19 EEA08471.1 - 1.7e-25 89.0 1.8 1.7e-25 89.0 1.8 1.6 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EEA08471.1 - 0.042 14.3 2.1 0.042 14.3 2.1 2.3 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region DS PF01916.17 EEA08473.1 - 2.6e-124 414.2 0.0 3e-124 414.0 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase MIF4G PF02854.19 EEA08474.1 - 6.6e-28 97.8 9.4 1.2e-27 97.0 9.4 1.5 1 0 0 1 1 1 1 MIF4G domain M-factor PF03855.13 EEA08475.1 - 0.063 13.4 0.0 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 M-factor Pkinase PF00069.25 EEA08477.1 - 1e-41 143.1 2.0 5.5e-38 130.8 1.5 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08477.1 - 2.5e-28 99.1 0.1 1.6e-26 93.1 0.0 2.1 1 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA08477.1 - 1.1e-10 41.3 0.0 1.7e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EEA08477.1 - 0.0014 17.7 0.3 0.0026 16.7 0.3 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EEA08477.1 - 0.0015 18.5 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EEA08477.1 - 0.0044 16.4 0.0 0.029 13.7 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family GD_N PF16030.5 EEA08477.1 - 0.013 15.8 0.9 0.039 14.3 0.2 2.1 2 0 0 2 2 2 0 Serine protease gd N-terminus Pkinase_fungal PF17667.1 EEA08477.1 - 0.048 12.4 0.2 0.055 12.2 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase Rad51 PF08423.11 EEA08478.1 - 9.6e-07 28.3 0.0 1.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EEA08478.1 - 0.0087 15.7 0.0 0.02 14.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EEA08478.1 - 0.074 13.6 0.4 0.21 12.1 0.1 2.0 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.6 EEA08478.1 - 0.25 11.9 1.5 0.49 10.9 0.6 2.0 1 1 1 2 2 2 0 AAA domain Fe-S_biosyn PF01521.20 EEA08479.1 - 1.2e-07 31.9 1.3 5.3e-07 29.8 1.2 2.0 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis CactinC_cactus PF09732.9 EEA08479.1 - 0.03 14.2 0.3 0.052 13.5 0.3 1.5 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein ABC_tran PF00005.27 EEA08480.1 - 1.4e-26 93.6 1.9 1.2e-13 51.8 0.0 3.9 3 0 0 3 3 3 2 ABC transporter AAA_29 PF13555.6 EEA08480.1 - 0.0013 18.4 3.4 0.92 9.3 0.1 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EEA08480.1 - 0.0029 17.7 0.4 0.12 12.4 0.0 3.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase SMC_N PF02463.19 EEA08480.1 - 0.0051 16.3 2.0 1.7 8.0 0.2 3.5 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EEA08480.1 - 0.018 14.4 0.3 2.7 7.3 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.17 EEA08480.1 - 0.025 14.7 0.1 0.025 14.7 0.1 4.1 5 0 0 5 5 5 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EEA08480.1 - 0.032 14.1 0.4 0.54 10.1 0.1 2.9 3 0 0 3 3 3 0 RsgA GTPase AAA_22 PF13401.6 EEA08480.1 - 0.14 12.4 0.0 17 5.7 0.0 3.1 2 0 0 2 2 2 0 AAA domain ABC_membrane PF00664.23 EEA08480.1 - 0.28 10.8 52.2 0.044 13.4 4.6 3.6 3 0 0 3 3 3 0 ABC transporter transmembrane region zf-B_box PF00643.24 EEA08481.1 - 4.3e-11 42.8 15.3 2e-06 27.8 1.1 2.9 2 0 0 2 2 2 2 B-box zinc finger PARP PF00644.20 EEA08481.1 - 0.01 15.4 1.7 0.082 12.5 1.0 2.7 2 1 0 2 2 2 0 Poly(ADP-ribose) polymerase catalytic domain DUF4922 PF16269.5 EEA08481.1 - 0.012 15.4 0.3 0.024 14.4 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) FH2 PF02181.23 EEA08482.1 - 1e-13 51.2 13.6 2.1e-08 33.7 4.3 2.7 2 0 0 2 2 2 2 Formin Homology 2 Domain Cg6151-P PF10233.9 EEA08483.1 - 0.067 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein CG6151-P Lysine_decarbox PF03641.14 EEA08483.1 - 0.079 13.1 0.2 0.31 11.1 0.1 2.1 2 0 0 2 2 2 0 Possible lysine decarboxylase RE_Eco29kI PF09517.10 EEA08483.1 - 0.092 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Eco29kI restriction endonuclease NIF PF03031.18 EEA08485.1 - 3e-51 173.3 0.1 3e-51 173.3 0.1 2.8 2 1 1 3 3 3 1 NLI interacting factor-like phosphatase Imm72 PF15584.6 EEA08486.1 - 0.11 12.6 0.2 0.41 10.8 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 72 EF-hand_1 PF00036.32 EEA08487.1 - 1.6e-11 42.9 1.5 9.7e-05 21.7 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EEA08487.1 - 8.9e-10 38.9 0.5 1.5e-09 38.2 0.5 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EEA08487.1 - 6.4e-09 34.9 2.3 5.3e-05 22.5 0.7 2.8 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.6 EEA08487.1 - 7.8e-07 28.5 1.8 0.00088 19.0 0.3 2.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EEA08487.1 - 3.7e-06 26.7 2.3 0.00065 19.5 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EEA08487.1 - 1.8e-05 25.0 0.1 2.4e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region UFD1 PF03152.14 EEA08489.1 - 1.6e-26 92.8 0.1 4.1e-26 91.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 zf_UBZ PF18439.1 EEA08489.1 - 0.05 13.2 15.5 0.14 11.7 0.6 4.8 4 1 1 5 5 5 0 Ubiquitin-Binding Zinc Finger XAF1_C PF18608.1 EEA08489.1 - 2 8.0 11.6 0.087 12.4 1.9 3.3 2 1 1 3 3 3 0 XIAP-associated factor 1 C-terminal domain DUF870 PF05912.11 EEA08490.1 - 0.0031 17.5 3.4 0.0031 17.5 3.4 1.8 2 1 0 2 2 2 1 Caenorhabditis elegans protein of unknown function (DUF870) SLED PF12140.8 EEA08490.1 - 0.45 11.0 9.4 0.32 11.5 0.8 2.7 1 1 2 3 3 3 0 SLED domain LOH1CR12 PF10158.9 EEA08490.1 - 3.2 7.8 16.7 8.6 6.4 7.2 2.9 1 1 2 3 3 3 0 Tumour suppressor protein RabGAP-TBC PF00566.18 EEA08491.1 - 9.8e-42 143.0 1.4 9.8e-42 143.0 1.4 2.3 2 1 1 3 3 3 1 Rab-GTPase-TBC domain DUF5427 PF10310.9 EEA08491.1 - 0.065 12.2 3.5 0.089 11.7 3.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DNA_pol3_delta2 PF13177.6 EEA08492.1 - 2.1e-09 37.3 0.0 4.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit T2SS_PulS_OutS PF09691.10 EEA08492.1 - 0.002 18.2 0.0 0.057 13.6 0.0 2.3 2 0 0 2 2 2 1 Type II secretion system pilotin lipoprotein (PulS_OutS) Rad17 PF03215.15 EEA08492.1 - 0.0034 17.3 0.0 0.0062 16.5 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 EEA08492.1 - 0.012 16.0 0.0 0.029 14.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EEA08492.1 - 0.066 13.6 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 Replication factor C C-terminal domain AAA_16 PF13191.6 EEA08492.1 - 0.11 12.8 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 EEA08493.1 - 4.7e-72 242.5 0.0 5.7e-72 242.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EEA08493.1 - 3.1e-42 144.7 0.0 4e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EEA08493.1 - 0.00098 18.5 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EEA08493.1 - 0.011 14.5 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EEA08493.1 - 0.11 12.1 0.2 0.25 10.9 0.2 1.6 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.14 EEA08493.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EEA08493.1 - 0.14 12.1 0.5 9.6 6.0 0.1 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family PGI PF00342.19 EEA08494.1 - 1.2e-171 571.6 0.0 1.4e-171 571.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase LSM14 PF12701.7 EEA08496.1 - 2.9e-27 94.6 0.0 6.5e-27 93.5 0.0 1.6 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EEA08496.1 - 3.1e-10 40.1 0.0 8.5e-10 38.6 0.0 1.8 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 EEA08496.1 - 0.00052 19.6 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 LSM domain FDF PF09532.10 EEA08496.1 - 0.0051 17.7 0.2 0.0051 17.7 0.2 3.4 2 1 1 3 3 3 1 FDF domain DUF4407 PF14362.6 EEA08496.1 - 0.3 10.4 1.7 0.29 10.5 0.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DnaJ PF00226.31 EEA08497.1 - 9.2e-26 89.8 3.0 2.4e-25 88.5 3.0 1.8 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 EEA08497.1 - 6.9e-14 51.7 0.1 2.9e-13 49.7 0.1 2.0 2 0 0 2 2 2 1 Thioredoxin AhpC-TSA PF00578.21 EEA08497.1 - 0.0014 18.6 0.4 0.0092 15.9 0.1 2.3 2 0 0 2 2 2 1 AhpC/TSA family TraF PF13728.6 EEA08497.1 - 0.0065 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 EEA08497.1 - 0.022 15.0 2.7 0.029 14.7 0.3 2.6 2 1 0 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.6 EEA08497.1 - 0.024 14.7 0.0 0.057 13.5 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_6 PF13848.6 EEA08497.1 - 0.039 13.9 7.2 0.038 13.9 1.3 3.3 3 1 0 3 3 3 0 Thioredoxin-like domain Redoxin PF08534.10 EEA08497.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Redoxin ArfGap PF01412.18 EEA08498.1 - 1.7e-32 111.9 0.4 1.7e-32 111.9 0.4 3.0 3 0 0 3 3 3 2 Putative GTPase activating protein for Arf CCM2_C PF16545.5 EEA08498.1 - 0.002 18.6 0.0 0.005 17.3 0.0 1.7 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology TPR_2 PF07719.17 EEA08499.1 - 8.4e-15 53.6 1.1 0.00014 21.7 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EEA08499.1 - 2.3e-14 52.5 2.7 1.9e-05 24.2 0.3 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EEA08499.1 - 2.6e-12 46.2 0.1 4.4e-06 26.3 0.0 3.6 1 1 2 3 3 3 3 TPR repeat ANAPC3 PF12895.7 EEA08499.1 - 3e-08 33.8 1.8 2.8e-07 30.7 0.2 3.1 2 1 0 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EEA08499.1 - 4.3e-08 33.5 5.8 0.0032 17.9 0.2 3.9 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EEA08499.1 - 3e-06 27.8 0.5 0.019 15.6 0.1 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EEA08499.1 - 6.7e-06 26.3 1.1 0.0017 18.6 0.0 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EEA08499.1 - 1.7e-05 25.2 2.4 0.07 14.0 0.1 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EEA08499.1 - 6e-05 22.9 7.8 0.39 11.0 0.1 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EEA08499.1 - 0.00023 21.6 0.4 7.6 7.4 0.0 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EEA08499.1 - 0.00047 20.3 1.6 0.56 10.7 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 EEA08499.1 - 0.0049 16.6 0.1 0.019 14.7 0.1 2.0 1 1 0 1 1 1 1 26S proteasome subunit RPN7 TPR_9 PF13371.6 EEA08499.1 - 0.019 15.1 0.0 0.59 10.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EEA08499.1 - 0.035 14.1 0.0 93 3.4 0.0 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 EEA08499.1 - 0.075 13.3 0.7 11 6.5 0.0 4.5 4 0 0 4 4 4 0 PPR repeat Med15_fungi PF05397.12 EEA08499.1 - 0.14 12.5 1.6 0.35 11.2 1.6 1.8 1 0 0 1 1 1 0 Mediator complex subunit 15 TPR_10 PF13374.6 EEA08499.1 - 0.16 11.9 2.8 1.1 9.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PGM_PMM_I PF02878.16 EEA08500.1 - 5.1e-27 94.3 0.0 7.6e-27 93.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EEA08500.1 - 3.5e-26 91.7 0.0 6.4e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EEA08500.1 - 8.8e-13 48.8 0.0 2.7e-12 47.2 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EEA08500.1 - 2.4e-07 30.8 0.0 5e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain pXO2-34 PF17362.2 EEA08500.1 - 0.065 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function PGM_PMM_I PF02878.16 EEA08501.1 - 5.1e-25 87.8 0.1 8.4e-25 87.1 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EEA08501.1 - 6.1e-25 87.6 0.0 1.3e-24 86.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EEA08501.1 - 1.6e-12 48.0 0.0 3.6e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EEA08501.1 - 0.011 15.9 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain RelB_leu_zip PF16180.5 EEA08502.1 - 0.014 15.4 0.1 1 9.4 0.0 2.4 2 0 0 2 2 2 0 RelB leucine zipper KIP1 PF07765.12 EEA08502.1 - 1.8 8.7 5.4 3.3 7.9 0.2 3.0 2 1 1 3 3 3 0 KIP1-like protein DHR10 PF18595.1 EEA08502.1 - 3.6 7.7 11.1 0.57 10.3 5.4 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain RMI1_N PF08585.12 EEA08503.1 - 2.6e-13 50.2 7.1 1.8e-08 34.5 0.0 3.2 3 0 0 3 3 3 2 RecQ mediated genome instability protein DUF1682 PF07946.14 EEA08504.1 - 0.052 12.8 0.1 0.078 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CmlA_N PF18456.1 EEA08504.1 - 0.087 12.1 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain DASH_Hsk3 PF08227.11 EEA08504.1 - 0.14 12.5 0.5 0.28 11.6 0.5 1.5 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like CLTH PF10607.9 EEA08504.1 - 6 6.8 11.0 6.7 6.6 1.2 2.9 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Peptidase_C1 PF00112.23 EEA08506.1 - 1.9e-36 126.2 2.8 8.8e-20 71.7 0.2 2.6 2 1 0 2 2 2 2 Papain family cysteine protease CathepsinC_exc PF08773.11 EEA08506.1 - 1.2e-14 54.6 2.5 2.2e-13 50.6 2.5 2.5 1 1 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EEA08506.1 - 0.00036 19.4 0.9 0.00067 18.5 0.9 1.3 1 0 0 1 1 1 1 Peptidase C1-like family HSP70 PF00012.20 EEA08507.1 - 9.2e-59 199.1 0.1 4.7e-57 193.5 0.1 3.2 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EEA08507.1 - 0.045 12.6 0.1 5.9 5.6 0.0 2.5 2 0 0 2 2 2 0 MreB/Mbl protein TonB_N PF16031.5 EEA08507.1 - 0.11 13.1 1.3 0.23 12.0 1.3 1.5 1 0 0 1 1 1 0 TonB polyproline region Pan3_PK PF18101.1 EEA08508.1 - 5.5e-46 156.0 0.1 9.3e-46 155.2 0.1 1.4 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EEA08508.1 - 2.8e-06 26.9 0.0 7.2e-06 25.6 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain Lebercilin PF15619.6 EEA08509.1 - 0.0026 17.5 6.1 0.0039 16.9 6.1 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Phage_int_SAM_6 PF18644.1 EEA08509.1 - 0.011 15.8 0.3 0.021 14.8 0.3 1.5 1 0 0 1 1 1 0 Phage integrase SAM-like domain FH2 PF02181.23 EEA08509.1 - 0.012 14.8 3.6 0.017 14.3 3.6 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain Spc7 PF08317.11 EEA08509.1 - 0.072 12.0 9.8 0.11 11.4 9.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF29 PF01724.16 EEA08509.1 - 0.096 12.9 3.8 0.11 12.7 2.5 1.7 1 1 1 2 2 2 0 Domain of unknown function DUF29 CutC PF03932.14 EEA08509.1 - 0.14 11.6 0.3 4.1 6.8 0.1 2.1 1 1 1 2 2 2 0 CutC family COG2 PF06148.11 EEA08509.1 - 0.23 11.6 4.4 0.23 11.5 2.1 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Atg14 PF10186.9 EEA08509.1 - 0.51 9.4 4.5 1.7 7.6 4.3 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CCDC23 PF15674.5 EEA08509.1 - 2.7 8.1 9.0 6.3 6.9 1.8 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 23 RAC_head PF16717.5 EEA08509.1 - 4.5 8.3 8.7 3.5 8.7 4.4 2.4 1 1 1 2 2 2 0 Ribosome-associated complex head domain DUF615 PF04751.14 EEA08509.1 - 7.8 6.5 10.7 7 6.6 9.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF615) SQHop_cyclase_C PF13243.6 EEA08510.1 - 0.19 10.8 0.0 0.32 10.1 0.0 1.2 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain DUF948 PF06103.11 EEA08510.1 - 0.8 10.0 5.3 28 5.1 0.8 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CSN8_PSD8_EIF3K PF10075.9 EEA08511.1 - 4.8e-23 81.7 0.0 8.6e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EEA08511.1 - 3.2e-08 33.3 0.4 4e-08 33.0 0.4 1.2 1 0 0 1 1 1 1 SAC3/GANP family XPG_N PF00752.17 EEA08511.1 - 0.11 13.0 0.8 1.4 9.5 0.1 2.5 3 0 0 3 3 3 0 XPG N-terminal domain FAM76 PF16046.5 EEA08512.1 - 3.2e-27 95.7 38.0 3.2e-27 95.7 38.0 2.2 1 1 0 2 2 2 1 FAM76 protein dCache_3 PF14827.6 EEA08512.1 - 0.039 13.6 0.4 0.058 13.0 0.4 1.3 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase CHASE3 PF05227.13 EEA08513.1 - 0.048 13.6 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 CHASE3 domain Slx4 PF09494.10 EEA08513.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 Slx4 endonuclease Dynamin_M PF01031.20 EEA08514.1 - 4.2e-93 311.7 1.1 4.2e-93 311.7 1.1 2.5 2 1 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EEA08514.1 - 2.4e-48 164.4 4.6 3.2e-48 164.0 0.1 2.8 2 1 0 2 2 2 1 Dynamin family GED PF02212.18 EEA08514.1 - 1.9e-26 92.0 3.3 6.9e-26 90.2 3.3 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EEA08514.1 - 3.9e-07 30.1 5.1 1.3e-06 28.4 0.1 3.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase Apolipo_F PF15148.6 EEA08514.1 - 0.025 14.0 0.0 0.057 12.9 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein F Cbl_N PF02262.16 EEA08514.1 - 0.048 13.7 2.5 2 8.4 0.0 3.4 3 0 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 Roc PF08477.13 EEA08514.1 - 0.061 13.5 0.0 1.1 9.5 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EEA08514.1 - 0.083 13.4 0.3 3.8 8.0 0.0 2.9 2 0 0 2 2 2 0 ABC transporter GDPD_2 PF13653.6 EEA08514.1 - 0.13 12.8 0.0 0.38 11.3 0.0 1.8 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Arf PF00025.21 EEA08515.1 - 2.5e-77 258.3 0.2 2.8e-77 258.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EEA08515.1 - 9.7e-15 54.8 0.0 1.4e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EEA08515.1 - 5e-14 52.2 0.0 5.6e-14 52.1 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EEA08515.1 - 6.4e-13 48.5 0.0 7.9e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EEA08515.1 - 3e-12 46.4 0.7 4.7e-08 32.6 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EEA08515.1 - 4.3e-10 39.3 0.0 5.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EEA08515.1 - 2e-05 24.7 0.0 3.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EEA08515.1 - 0.0042 16.7 0.1 0.01 15.4 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.18 EEA08515.1 - 0.008 15.5 0.2 0.016 14.5 0.1 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase RsgA_GTPase PF03193.16 EEA08515.1 - 0.022 14.7 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 EEA08515.1 - 0.14 12.3 0.3 0.42 10.8 0.3 1.9 1 1 0 1 1 1 0 AAA domain PDCD2_C PF04194.13 EEA08516.1 - 4.7e-34 118.0 6.3 3.3e-32 112.0 1.4 2.2 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain PriA_CRR PF18319.1 EEA08516.1 - 0.24 11.4 2.2 46 4.1 0.1 3.6 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain C1_2 PF03107.16 EEA08516.1 - 0.56 10.6 10.4 2.9 8.3 0.0 4.7 5 0 0 5 5 5 0 C1 domain SDA1 PF05285.12 EEA08517.1 - 1.2e-40 140.0 41.6 6.6e-39 134.3 32.2 3.1 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EEA08517.1 - 6.5e-12 45.6 0.0 5.2e-11 42.7 0.0 2.7 2 0 0 2 2 2 1 NUC130/3NT domain Telomerase_RBD PF12009.8 EEA08519.1 - 1.6e-27 96.3 6.7 7e-27 94.2 6.7 2.2 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EEA08519.1 - 9.7e-08 31.8 0.3 0.052 13.1 0.0 3.9 3 0 0 3 3 3 3 Reverse transcriptase (RNA-dependent DNA polymerase) UCH PF00443.29 EEA08520.1 - 1.1e-17 64.5 4.5 1.6e-17 63.9 4.5 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA08520.1 - 4.5e-06 26.5 3.2 6.4e-06 26.0 3.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MCM_N PF14551.6 EEA08520.1 - 0.027 15.1 0.3 0.047 14.3 0.3 1.5 1 0 0 1 1 1 0 MCM N-terminal domain XPC-binding PF09280.11 EEA08520.1 - 0.096 12.4 4.1 0.21 11.3 3.4 1.9 2 0 0 2 2 2 0 XPC-binding domain Acyl_transf_3 PF01757.22 EEA08521.1 - 8.5e-16 57.9 47.3 1.7e-14 53.6 47.3 2.6 1 1 0 1 1 1 1 Acyltransferase family Peptidase_S7 PF00949.21 EEA08523.1 - 0.14 12.0 0.7 8.1 6.3 0.0 2.7 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease Blt1_C PF17183.4 EEA08523.1 - 0.15 11.7 0.1 0.34 10.5 0.1 1.6 1 0 0 1 1 1 0 Get5 carboxyl domain KIX_2 PF16987.5 EEA08524.1 - 0.089 12.8 0.1 15 5.7 0.1 2.8 3 0 0 3 3 3 0 KIX domain Sedlin_N PF04628.13 EEA08525.1 - 3.3e-17 62.9 0.2 3.8e-17 62.6 0.2 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EEA08525.1 - 0.0053 16.7 0.1 0.0062 16.5 0.1 1.2 1 0 0 1 1 1 1 Sybindin-like family DUF573 PF04504.14 EEA08526.1 - 1.1 9.9 6.7 3.5 8.4 1.4 3.1 2 1 1 3 3 3 0 Protein of unknown function, DUF573 ATG101 PF07855.12 EEA08526.1 - 1.5 8.8 6.1 19 5.2 0.1 3.4 3 1 0 3 3 3 0 Autophagy-related protein 101 zf-ZPR1 PF03367.13 EEA08527.1 - 0.029 14.2 2.5 0.35 10.7 0.3 2.1 2 0 0 2 2 2 0 ZPR1 zinc-finger domain DUF5082 PF16888.5 EEA08527.1 - 1.3 9.4 10.6 0.049 13.9 4.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) GST_C_3 PF14497.6 EEA08528.1 - 5.5e-05 23.3 0.0 9.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SNF2_N PF00176.23 EEA08531.1 - 1.9e-69 234.0 1.3 5.3e-69 232.6 1.3 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EEA08531.1 - 3.3e-19 69.3 0.0 1.7e-18 66.9 0.0 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EEA08531.1 - 7.1e-08 32.6 0.0 7.1e-08 32.6 0.0 3.5 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EEA08531.1 - 5.9e-05 22.9 0.1 0.0012 18.6 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase BOP1NT PF08145.12 EEA08533.1 - 2.5e-84 283.3 1.1 3.6e-84 282.7 1.1 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EEA08533.1 - 2.7e-07 31.2 2.4 7.4 7.6 0.1 6.9 6 1 0 6 6 6 2 WD domain, G-beta repeat DUF3140 PF11338.8 EEA08533.1 - 0.0067 16.8 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3140) BACK PF07707.15 EEA08534.1 - 0.01 15.9 2.5 0.081 13.0 0.6 2.7 2 0 0 2 2 2 0 BTB And C-terminal Kelch Peptidase_S8 PF00082.22 EEA08535.1 - 5.5e-39 134.2 0.2 1.6e-38 132.7 0.0 1.7 2 0 0 2 2 2 1 Subtilase family Bromodomain PF00439.25 EEA08537.1 - 0.00065 19.7 0.0 0.0019 18.2 0.0 1.8 1 0 0 1 1 1 1 Bromodomain F-box-like PF12937.7 EEA08539.1 - 6.6e-05 22.7 2.3 6.6e-05 22.7 2.3 2.5 2 0 0 2 2 2 1 F-box-like WD40 PF00400.32 EEA08539.1 - 0.0058 17.4 9.0 0.033 15.1 0.2 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat F-box PF00646.33 EEA08539.1 - 2.4 8.1 12.2 0.7 9.8 4.3 3.4 3 0 0 3 3 3 0 F-box domain Xpo1 PF08389.12 EEA08540.1 - 6.1e-06 26.4 2.6 6.1e-06 26.4 2.6 5.9 5 2 0 5 5 5 2 Exportin 1-like protein Mononeg_mRNAcap PF14318.6 EEA08540.1 - 0.054 12.7 0.2 0.12 11.6 0.2 1.5 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V Chorein_N PF12624.7 EEA08541.1 - 3.7e-08 33.5 0.9 3.7e-08 33.5 0.9 3.1 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 Dus PF01207.17 EEA08543.1 - 6.7e-39 133.8 0.0 2.3e-29 102.5 0.0 3.2 3 0 0 3 3 3 3 Dihydrouridine synthase (Dus) SidC_N PF18219.1 EEA08543.1 - 0.048 12.6 0.1 0.25 10.3 0.0 2.0 2 0 0 2 2 2 0 SidC N-terminal domain PrsW-protease PF13367.6 EEA08544.1 - 1.3e-12 47.6 5.8 2.5e-10 40.1 5.2 3.2 2 1 0 2 2 2 1 PrsW family intramembrane metalloprotease Maf1 PF09174.10 EEA08544.1 - 0.019 15.1 1.3 0.021 15.0 0.1 1.7 2 0 0 2 2 2 0 Maf1 regulator Nsp1_C PF05064.13 EEA08545.1 - 1.1e-12 47.8 5.1 1.1e-12 47.8 5.1 2.7 1 1 1 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EEA08545.1 - 0.0009 20.0 26.0 0.0009 20.0 26.0 4.7 1 1 3 4 4 4 2 Nucleoporin FG repeat region DUF3209 PF11483.8 EEA08545.1 - 0.079 13.4 0.4 0.15 12.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) APG6_N PF17675.1 EEA08545.1 - 0.24 11.9 6.3 0.27 11.8 5.0 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Filament PF00038.21 EEA08545.1 - 0.68 9.4 13.0 0.42 10.2 1.0 2.3 1 1 0 2 2 2 0 Intermediate filament protein BLOC1_2 PF10046.9 EEA08545.1 - 3 8.2 8.7 9.8 6.6 1.7 2.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.20 EEA08545.1 - 7.8 6.5 11.1 5.8 6.9 2.9 3.1 3 0 0 3 3 3 0 Prefoldin subunit zf-HC5HC2H_2 PF13832.6 EEA08546.1 - 1.9e-17 63.4 17.6 8.6e-11 42.0 6.0 6.6 7 0 0 7 7 7 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EEA08546.1 - 1e-11 44.9 19.9 5.3e-09 36.2 7.9 6.9 7 0 0 7 7 7 2 PHD-like zinc-binding domain PHD PF00628.29 EEA08546.1 - 2.7e-09 36.8 22.9 3.5e-06 26.8 10.7 6.2 5 1 1 6 6 6 3 PHD-finger DUF3268 PF11672.8 EEA08546.1 - 0.093 13.1 0.0 0.093 13.1 0.0 3.5 4 0 0 4 4 4 0 zinc-finger-containing domain Bd3614-deam PF14439.6 EEA08546.1 - 0.11 12.5 0.0 0.53 10.3 0.0 2.1 2 0 0 2 2 2 0 Bd3614-like deaminase THEG PF14912.6 EEA08546.1 - 0.16 12.4 0.0 0.44 11.0 0.0 1.7 1 0 0 1 1 1 0 Testicular haploid expressed repeat zf-PHD-like PF15446.6 EEA08546.1 - 0.27 10.8 11.1 0.15 11.7 0.5 4.3 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain DUF382 PF04037.13 EEA08547.1 - 8.4e-52 174.6 0.6 8.4e-52 174.6 0.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EEA08547.1 - 1.2e-19 69.9 6.4 1.2e-19 69.9 6.4 2.1 2 0 0 2 2 2 1 PSP AP2 PF00847.20 EEA08549.1 - 3.5e-14 52.8 3.6 7.7e-14 51.7 3.6 1.6 1 0 0 1 1 1 1 AP2 domain DUF2024 PF09630.10 EEA08550.1 - 0.078 12.9 0.2 0.11 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) TSP_1 PF00090.19 EEA08552.1 - 5.2e-22 77.8 40.2 3.7e-11 43.1 6.1 4.6 4 0 0 4 4 4 4 Thrombospondin type 1 domain Kringle PF00051.18 EEA08552.1 - 1.6e-09 37.9 2.6 4.5e-09 36.5 0.5 2.7 2 0 0 2 2 2 1 Kringle domain zf-CCCH_6 PF18585.1 EEA08552.1 - 0.19 11.6 5.1 3.9 7.4 0.1 3.2 3 0 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 OppC_N PF12911.7 EEA08552.1 - 0.37 10.8 2.3 0.69 9.9 0.2 2.1 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Sigma_reg_N PF13800.6 EEA08552.1 - 1.1 9.6 4.1 0.81 10.0 0.2 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal SPT_ssu-like PF11779.8 EEA08552.1 - 2.8 7.6 9.3 0.13 11.9 3.3 2.0 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like Orf78 PF06024.12 EEA08552.1 - 8.5 6.7 7.4 0.34 11.2 0.3 2.0 2 0 0 2 2 2 0 Orf78 (ac78) HMG_box PF00505.19 EEA08553.1 - 2e-15 56.9 5.0 2e-15 56.9 5.0 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EEA08553.1 - 7.2e-10 39.3 5.1 1.2e-09 38.6 5.1 1.4 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 EEA08553.1 - 0.00041 20.2 0.3 0.00069 19.5 0.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box 5 Elongin_A PF06881.11 EEA08553.1 - 2.6 8.6 6.5 8.1 7.0 6.9 1.6 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A bPH_3 PF14470.6 EEA08556.1 - 0.0043 17.4 0.1 0.0067 16.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial PH domain Voldacs PF03517.13 EEA08556.1 - 0.055 13.6 0.0 0.14 12.3 0.0 1.7 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling AAA PF00004.29 EEA08557.1 - 7e-53 178.6 0.1 4.6e-40 137.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EEA08557.1 - 1.2e-10 42.0 0.1 0.00056 20.3 0.1 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EEA08557.1 - 6.6e-10 39.4 2.3 0.0058 16.9 0.0 4.4 2 2 2 4 4 4 2 AAA domain AAA_lid_3 PF17862.1 EEA08557.1 - 5.2e-09 35.8 0.0 1.3e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EEA08557.1 - 3e-08 33.8 0.0 0.0002 21.4 0.1 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EEA08557.1 - 6.3e-07 29.7 0.0 5.3e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EEA08557.1 - 1.3e-06 28.4 0.6 0.089 12.8 0.0 2.9 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.26 EEA08557.1 - 2.4e-06 27.4 0.1 0.019 14.7 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain TIP49 PF06068.13 EEA08557.1 - 3.3e-06 26.6 0.2 0.041 13.1 0.0 2.7 3 0 0 3 3 3 2 TIP49 P-loop domain TsaE PF02367.17 EEA08557.1 - 5.3e-06 26.4 0.0 0.079 13.0 0.0 2.8 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EEA08557.1 - 9.2e-06 25.5 0.1 0.0088 15.8 0.0 3.1 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EEA08557.1 - 1.3e-05 24.7 0.1 0.00085 18.8 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EEA08557.1 - 1.5e-05 25.3 0.0 0.052 13.9 0.0 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 EEA08557.1 - 3.5e-05 23.8 0.1 0.39 10.6 0.0 3.7 3 0 0 3 3 3 1 NACHT domain ATPase_2 PF01637.18 EEA08557.1 - 5.6e-05 23.2 0.8 1.1 9.1 0.1 3.7 3 1 1 4 4 4 2 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EEA08557.1 - 0.00012 21.9 0.0 0.06 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EEA08557.1 - 0.0002 20.8 0.2 0.87 9.0 0.0 3.3 2 1 1 3 3 3 2 Bacterial TniB protein AAA_7 PF12775.7 EEA08557.1 - 0.00024 20.7 0.0 0.025 14.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 EEA08557.1 - 0.00025 21.6 0.2 0.084 13.4 0.1 2.7 2 0 0 2 2 2 1 ABC transporter AAA_33 PF13671.6 EEA08557.1 - 0.0003 20.9 0.0 0.024 14.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EEA08557.1 - 0.00045 20.1 0.0 0.045 13.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EEA08557.1 - 0.00069 18.9 0.0 0.64 9.1 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Torsin PF06309.11 EEA08557.1 - 0.0011 19.1 0.0 0.26 11.4 0.0 2.8 2 0 0 2 2 2 1 Torsin AAA_18 PF13238.6 EEA08557.1 - 0.0011 19.5 0.0 0.17 12.4 0.0 3.1 3 0 0 3 3 2 1 AAA domain ATPase PF06745.13 EEA08557.1 - 0.0028 17.1 0.0 0.036 13.4 0.0 2.6 2 0 0 2 2 2 1 KaiC Sigma54_activ_2 PF14532.6 EEA08557.1 - 0.0042 17.2 0.0 1.1 9.4 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 EEA08557.1 - 0.0047 16.7 0.0 0.41 10.4 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein DUF815 PF05673.13 EEA08557.1 - 0.0047 16.1 0.1 0.21 10.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EEA08557.1 - 0.0063 16.1 0.3 1.3 8.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EEA08557.1 - 0.0076 16.0 0.0 0.095 12.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain DAP3 PF10236.9 EEA08557.1 - 0.0083 15.3 0.3 0.43 9.7 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 Parvo_NS1 PF01057.17 EEA08557.1 - 0.0085 15.2 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EEA08557.1 - 0.01 15.1 0.1 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 EEA08557.1 - 0.016 15.0 0.1 4.4 7.1 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_19 PF13245.6 EEA08557.1 - 0.019 15.3 0.0 0.068 13.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain UPF0137 PF03677.13 EEA08557.1 - 0.042 13.6 0.5 2.8 7.7 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0137) AAA_11 PF13086.6 EEA08557.1 - 0.058 13.2 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EEA08557.1 - 0.072 12.3 0.0 0.57 9.4 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EEA08557.1 - 0.087 12.8 0.0 0.49 10.4 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 EEA08557.1 - 0.1 12.9 0.0 0.4 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EEA08557.1 - 0.15 11.5 0.1 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Ribosomal_S9 PF00380.19 EEA08558.1 - 1.8e-28 99.5 0.1 2e-28 99.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13e PF01294.18 EEA08559.1 - 2.2e-69 232.9 1.5 2.6e-69 232.7 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L13e SPG48 PF14764.6 EEA08560.1 - 6.2e-07 29.9 0.4 9.7e-06 26.0 0.0 2.8 2 0 0 2 2 2 1 AP-5 complex subunit, vesicle trafficking SHS2_Rpb7-N PF03876.17 EEA08561.1 - 2.6e-12 46.9 0.0 5.1e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 EEA08561.1 - 2.8e-08 34.0 0.0 4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 S1 PF00575.23 EEA08561.1 - 3.9e-07 30.3 0.0 6.8e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain DUF2110 PF09883.9 EEA08561.1 - 0.065 12.8 0.0 0.17 11.5 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Metallophos PF00149.28 EEA08562.1 - 2.2e-31 110.0 2.0 4.3e-31 109.0 2.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EEA08562.1 - 1e-15 57.8 0.6 7.4e-15 55.0 0.6 2.2 1 1 0 1 1 1 1 PPP5 TPR repeat region TPR_2 PF07719.17 EEA08562.1 - 3.4e-14 51.7 1.9 0.00016 21.5 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EEA08562.1 - 4.3e-14 51.6 3.9 0.00019 21.1 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EEA08562.1 - 2.3e-08 33.6 4.4 0.0012 18.9 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EEA08562.1 - 6.5e-06 26.3 2.2 0.00012 22.3 0.4 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EEA08562.1 - 0.00084 19.6 0.2 0.0064 16.8 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EEA08562.1 - 0.00092 18.9 5.0 0.17 11.6 0.2 3.0 3 0 0 3 3 3 2 TPR repeat TPR_9 PF13371.6 EEA08562.1 - 0.023 14.9 0.0 2.7 8.2 0.0 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EEA08562.1 - 0.17 12.6 0.4 5.9 7.6 0.0 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat zf-RING_2 PF13639.6 EEA08563.1 - 9.8e-08 32.2 11.7 9.8e-08 32.2 11.7 3.1 2 0 0 2 2 2 1 Ring finger domain Vac14_Fab1_bd PF12755.7 EEA08563.1 - 4e-05 24.1 4.6 0.021 15.4 0.0 4.9 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region zf-rbx1 PF12678.7 EEA08563.1 - 4.6e-05 23.6 9.8 0.00014 22.1 9.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EEA08563.1 - 5.2e-05 23.3 6.5 0.00019 21.5 6.5 2.1 1 0 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 EEA08563.1 - 0.00024 20.9 13.0 0.00068 19.4 11.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EEA08563.1 - 0.00074 19.1 7.4 0.0022 17.6 7.4 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EEA08563.1 - 0.0014 18.6 11.3 0.0066 16.5 10.5 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EEA08563.1 - 0.0015 18.4 12.9 0.0015 18.4 12.9 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EEA08563.1 - 0.003 17.6 5.1 0.0083 16.2 5.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EEA08563.1 - 0.14 11.9 7.8 0.48 10.2 7.8 2.1 1 0 0 1 1 1 0 RING-like zinc finger RINGv PF12906.7 EEA08563.1 - 0.21 11.7 9.4 0.59 10.3 9.4 1.9 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EEA08563.1 - 0.79 9.6 6.8 2.2 8.2 6.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit C1_1 PF00130.22 EEA08563.1 - 1.4 8.9 9.8 4.4 7.3 9.8 1.9 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_4 PF15227.6 EEA08563.1 - 4.3 7.6 7.7 34 4.7 7.7 2.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING KH_1 PF00013.29 EEA08564.1 - 0.00018 21.3 0.2 0.00039 20.2 0.2 1.5 1 0 0 1 1 1 1 KH domain CCDC32 PF14989.6 EEA08564.1 - 0.094 12.7 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing 32 OST-HTH PF12872.7 EEA08564.1 - 0.15 11.9 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 OST-HTH/LOTUS domain DUF1664 PF07889.12 EEA08565.1 - 0.74 9.9 42.0 0.28 11.2 8.7 5.4 3 1 1 5 5 5 0 Protein of unknown function (DUF1664) MbeD_MobD PF04899.12 EEA08565.1 - 0.78 9.9 15.2 2.6 8.2 1.8 4.3 3 1 1 4 4 4 0 MbeD/MobD like H-kinase_dim PF02895.14 EEA08565.1 - 9.6 6.7 13.5 6.1 7.3 0.0 4.6 3 1 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain ER_lumen_recept PF00810.18 EEA08566.1 - 2.6e-31 109.4 8.2 2.6e-31 109.4 8.2 2.1 3 0 0 3 3 3 1 ER lumen protein retaining receptor Mntp PF02659.15 EEA08566.1 - 0.013 15.2 0.6 0.013 15.2 0.6 1.9 2 1 0 2 2 2 0 Putative manganese efflux pump UL42 PF17638.2 EEA08566.1 - 0.19 11.7 0.1 0.37 10.8 0.1 1.4 1 0 0 1 1 1 0 HCMV UL42 WD40 PF00400.32 EEA08567.1 - 1.5e-20 73.1 14.5 0.0017 19.1 0.8 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat Utp12 PF04003.12 EEA08567.1 - 2.2e-09 37.6 0.0 4.7e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EEA08567.1 - 0.00044 19.3 0.1 0.12 11.3 0.0 3.1 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 EEA08567.1 - 0.055 12.6 0.0 4.1 6.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1513) DUF3165 PF11364.8 EEA08567.1 - 5.3 7.5 7.2 0.67 10.3 2.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) Peptidase_M16_M PF16187.5 EEA08568.1 - 1.1e-24 87.2 19.6 1.4e-18 67.2 5.6 3.2 3 0 0 3 3 3 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EEA08568.1 - 1.6e-23 83.7 0.3 6.6e-16 58.9 0.1 2.8 2 1 0 2 2 2 2 Peptidase M16 inactive domain DNA_pol_B PF00136.21 EEA08569.1 - 1.7e-103 346.8 3.7 2.8e-103 346.1 3.7 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EEA08569.1 - 2.5e-25 89.4 4.2 2.5e-25 89.4 4.2 3.3 3 1 0 3 3 3 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EEA08569.1 - 1.2e-18 66.9 5.7 1.2e-18 66.9 5.7 2.4 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal zf-DNA_Pol PF08996.10 EEA08569.1 - 0.013 15.3 5.1 0.035 13.9 5.1 1.8 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger V-SNARE_C PF12352.8 EEA08570.1 - 2.1e-06 27.9 0.8 2.3e-05 24.6 0.5 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF3043 PF11241.8 EEA08570.1 - 0.0083 16.2 0.0 0.084 12.9 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3043) Mit_KHE1 PF10173.9 EEA08570.1 - 0.011 15.8 2.1 0.94 9.5 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related Lip_prot_lig_C PF10437.9 EEA08570.1 - 0.041 13.9 0.3 0.41 10.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus Pkinase_Tyr PF07714.17 EEA08571.1 - 2.2e-39 135.3 0.0 1.4e-37 129.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EEA08571.1 - 6.1e-34 117.6 0.0 1.4e-32 113.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain SAM_2 PF07647.17 EEA08571.1 - 0.00027 21.0 0.0 0.00096 19.2 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EEA08571.1 - 0.00056 18.8 0.0 0.00092 18.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SAM_1 PF00536.30 EEA08571.1 - 0.11 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) RNA_pol_Rpb4 PF03874.16 EEA08572.1 - 2.5e-13 50.4 1.0 4.8e-13 49.5 1.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb4 DUF3839 PF12943.7 EEA08572.1 - 0.055 12.9 0.0 0.069 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3839) Metallophos PF00149.28 EEA08573.1 - 6.8e-09 36.5 2.9 1.5e-08 35.4 2.9 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EEA08573.1 - 0.0012 19.0 1.0 0.0021 18.3 0.1 1.8 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain DBR1 PF05011.13 EEA08573.1 - 0.0058 17.1 0.4 0.0087 16.5 0.4 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain TUDOR PF00567.24 EEA08574.1 - 0.21 11.6 1.1 0.48 10.5 0.1 2.1 2 0 0 2 2 2 0 Tudor domain Aa_trans PF01490.18 EEA08576.1 - 1.7e-45 155.5 48.3 3e-45 154.7 48.3 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EEA08576.1 - 9e-07 28.3 17.2 9e-07 28.3 17.2 2.7 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family Mucin PF01456.17 EEA08577.1 - 0.6 10.1 46.3 0.089 12.8 38.0 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein DegS PF05384.11 EEA08578.1 - 0.0071 15.8 12.4 0.0071 15.8 12.4 1.9 1 1 1 2 2 2 1 Sensor protein DegS Jnk-SapK_ap_N PF09744.9 EEA08578.1 - 0.0076 16.5 11.3 0.0076 16.5 11.3 2.0 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 ATG16 PF08614.11 EEA08578.1 - 0.031 14.5 15.0 0.56 10.4 2.5 2.6 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Vfa1 PF08432.10 EEA08578.1 - 0.44 10.9 12.2 0.62 10.4 12.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF262 PF03235.14 EEA08578.1 - 0.52 10.4 6.8 0.64 10.1 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF4407 PF14362.6 EEA08578.1 - 0.61 9.4 7.9 1.6 8.0 7.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1840 PF08895.11 EEA08578.1 - 0.7 10.2 5.2 1 9.7 4.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) Ax_dynein_light PF10211.9 EEA08578.1 - 0.79 9.6 19.5 3.2 7.6 9.9 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain FlxA PF14282.6 EEA08578.1 - 1.4 9.0 16.2 5.4 7.1 8.7 2.6 1 1 0 2 2 2 0 FlxA-like protein HalX PF08663.10 EEA08578.1 - 2.9 8.3 7.8 0.24 11.7 0.4 2.6 3 1 0 3 3 3 0 HalX domain Allexi_40kDa PF05549.11 EEA08578.1 - 3.7 7.0 5.6 1.5 8.2 3.1 1.6 1 1 1 2 2 2 0 Allexivirus 40kDa protein eIF3_subunit PF08597.10 EEA08578.1 - 9.3 6.1 16.4 0.92 9.4 11.6 1.7 1 1 1 2 2 2 0 Translation initiation factor eIF3 subunit SRP40_C PF05022.12 EEA08579.1 - 3.8e-21 75.7 5.0 3.8e-21 75.7 5.0 2.6 4 0 0 4 4 4 1 SRP40, C-terminal domain TFCD_C PF12612.8 EEA08579.1 - 0.038 13.8 0.9 0.065 13.1 0.9 1.3 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal Ribosomal_S17_N PF16205.5 EEA08580.1 - 5.6e-30 103.5 0.2 1.2e-29 102.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EEA08580.1 - 1.9e-27 95.1 2.2 2.6e-27 94.7 0.8 1.9 2 0 0 2 2 2 1 Ribosomal protein S17 IMS PF00817.20 EEA08581.1 - 2.8e-36 124.8 0.0 4.8e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EEA08581.1 - 0.00071 20.3 0.0 0.0032 18.2 0.0 2.1 1 1 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF1805 PF08827.11 EEA08581.1 - 0.02 15.2 0.0 0.052 13.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) TrbI_Ftype PF09677.10 EEA08581.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) DUF5640 PF18692.1 EEA08581.1 - 0.2 11.7 4.7 0.14 12.2 1.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5640) MCR PF18509.1 EEA08581.1 - 0.26 10.9 0.4 0.52 9.9 0.4 1.4 1 0 0 1 1 1 0 Magnetochrome domain zf_UBZ PF18439.1 EEA08581.1 - 1 9.0 2.6 0.58 9.8 0.3 1.9 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger RNase_PH PF01138.21 EEA08582.1 - 3.6e-25 89.0 0.4 6.8e-25 88.1 0.4 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PPI_Ypi1 PF07491.11 EEA08583.1 - 1.7e-22 79.0 10.0 3.7e-22 77.9 10.0 1.7 1 1 0 1 1 1 1 Protein phosphatase inhibitor DUF3124 PF11322.8 EEA08583.1 - 0.023 14.9 0.8 0.036 14.3 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3124) zf-primase PF09329.11 EEA08583.1 - 0.06 13.2 0.5 0.06 13.2 0.5 2.0 2 0 0 2 2 2 0 Primase zinc finger RPN2_C PF18004.1 EEA08584.1 - 3.7e-34 118.0 2.3 9.3e-34 116.7 2.3 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EEA08584.1 - 9.4e-33 111.0 30.8 8.9e-08 32.2 0.1 10.2 10 0 0 10 10 10 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EEA08584.1 - 4.5e-18 65.4 0.0 7.8e-11 42.2 0.0 4.6 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 EEA08584.1 - 1.5e-06 27.9 0.4 0.16 12.3 0.0 5.6 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 EEA08584.1 - 0.0073 16.8 0.4 0.088 13.3 0.1 3.0 3 0 0 3 3 3 1 HEAT-like repeat ANAPC3 PF12895.7 EEA08584.1 - 0.022 14.9 6.4 0.077 13.2 0.5 3.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Cnd1 PF12717.7 EEA08584.1 - 0.028 14.5 0.0 0.028 14.5 0.0 3.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EEA08584.1 - 0.15 12.8 2.4 23 6.0 0.0 4.2 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat TPR_8 PF13181.6 EEA08584.1 - 0.38 11.1 4.3 0.41 11.0 0.4 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EEA08584.1 - 3.5 8.0 9.5 0.45 10.8 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Spc29 PF17082.5 EEA08585.1 - 6.7e-05 22.9 1.4 6.7e-05 22.9 1.4 1.8 1 1 1 2 2 2 1 Spindle Pole Component 29 HAP1_N PF04849.13 EEA08585.1 - 0.0087 15.3 12.0 0.052 12.7 11.5 2.0 1 1 1 2 2 2 1 HAP1 N-terminal conserved region GIT_CC PF16559.5 EEA08585.1 - 0.021 14.7 4.6 0.53 10.2 0.1 3.2 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor FAM184 PF15665.5 EEA08585.1 - 0.029 14.2 6.3 1.3 8.7 1.4 2.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B CENP-H PF05837.12 EEA08585.1 - 0.053 13.9 8.0 1.2 9.6 1.7 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.12 EEA08585.1 - 0.18 11.9 8.5 0.37 10.9 8.5 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 EEA08585.1 - 0.36 11.1 12.3 0.2 11.9 6.3 2.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 EEA08585.1 - 1.5 8.3 5.5 1.7 8.1 5.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit bZIP_2 PF07716.15 EEA08585.1 - 2.1 8.5 7.2 1.4 9.1 0.6 2.8 2 1 1 3 3 3 0 Basic region leucine zipper DUF3149 PF11346.8 EEA08586.1 - 0.34 10.5 7.9 0.57 9.8 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Vps51 PF08700.11 EEA08587.1 - 1.6e-10 40.9 0.8 1.6e-10 40.9 0.8 3.5 4 0 0 4 4 4 1 Vps51/Vps67 CYTL1 PF15153.6 EEA08587.1 - 0.031 14.2 0.2 0.031 14.2 0.2 3.1 3 0 0 3 3 3 0 Cytokine-like protein 1 Acetyltransf_1 PF00583.25 EEA08589.1 - 3.6e-14 53.0 0.0 4.4e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EEA08589.1 - 5.4e-09 36.1 0.0 7.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EEA08589.1 - 3.1e-08 33.9 0.0 3.9e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EEA08589.1 - 0.00048 20.2 0.0 0.00085 19.4 0.0 1.6 1 1 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EEA08589.1 - 0.00075 19.4 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EEA08589.1 - 0.0017 18.5 0.1 0.0021 18.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EEA08589.1 - 0.0064 16.1 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase PanZ PF12568.8 EEA08589.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ DUF1415 PF07209.12 EEA08589.1 - 0.017 14.9 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) FAP PF07174.11 EEA08591.1 - 1.7 8.0 22.5 2 7.8 22.5 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Peptidase_M16 PF00675.20 EEA08592.1 - 8.1e-37 126.5 0.0 1.6e-36 125.5 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA08592.1 - 7.3e-16 58.7 0.3 1.3e-15 57.9 0.3 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain CpeT PF06206.11 EEA08593.1 - 0.065 13.2 1.7 0.075 13.0 0.7 1.6 2 0 0 2 2 2 0 CpeT/CpcT family (DUF1001) eIF2_C PF09173.11 EEA08594.1 - 0.054 13.8 0.3 0.16 12.2 0.3 1.8 1 0 0 1 1 1 0 Initiation factor eIF2 gamma, C terminal ATP_sub_h PF10775.9 EEA08594.1 - 0.13 12.3 0.1 0.32 11.0 0.1 1.7 1 0 0 1 1 1 0 ATP synthase complex subunit h VPR PF00522.18 EEA08594.1 - 0.15 12.1 0.1 0.15 12.1 0.1 3.3 4 0 0 4 4 4 0 VPR/VPX protein RPN5_C PF18098.1 EEA08594.1 - 0.19 11.8 2.8 0.29 11.3 1.2 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN5 C-terminal domain RNase_J_C PF17770.1 EEA08595.1 - 8.2 7.6 8.1 4.5 8.4 0.1 3.9 5 0 0 5 5 5 0 Ribonuclease J C-terminal domain Peptidase_M16 PF00675.20 EEA08596.1 - 6.8e-15 55.3 0.6 1.5e-14 54.2 0.6 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EEA08596.1 - 1.8e-11 44.4 1.9 5.1e-11 42.9 0.0 2.6 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16_C PF05193.21 EEA08597.1 - 7.5e-10 39.1 3.4 2e-09 37.8 0.3 2.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EEA08597.1 - 4.3e-09 36.5 0.1 9.4e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Bcl-2_3 PF15286.6 EEA08597.1 - 0.4 11.3 4.7 0.89 10.2 0.2 3.5 3 0 0 3 3 3 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like RPS31 PF17067.5 EEA08598.1 - 0.054 13.7 0.2 2.8 8.2 0.0 3.2 3 1 1 4 4 4 0 Ribosomal protein S31e Pkinase PF00069.25 EEA08599.1 - 3.1e-11 43.2 6.7 1.8e-07 30.8 0.0 3.4 3 1 0 3 3 3 2 Protein kinase domain Matrilin_ccoil PF10393.9 EEA08600.1 - 0.064 13.1 7.2 0.57 10.1 1.4 3.1 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin TetR_C_2 PF08361.11 EEA08600.1 - 0.86 9.7 5.3 4.4 7.4 0.2 3.3 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region DUF4502 PF14950.6 EEA08601.1 - 3.5 7.0 12.3 3 7.2 6.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4502) IQ PF00612.27 EEA08602.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 IQ calmodulin-binding motif SART-1 PF03343.13 EEA08604.1 - 4.4e-20 71.8 17.5 3.8e-17 62.1 0.2 2.1 1 1 1 2 2 2 2 SART-1 family DUF421 PF04239.12 EEA08604.1 - 0.00054 19.7 7.3 0.0029 17.3 0.6 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF421) DUF1284 PF06935.11 EEA08604.1 - 6.7 7.2 8.3 1.9 9.0 0.7 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF1284) FtsJ PF01728.19 EEA08605.1 - 1.5e-58 197.8 0.2 6.1e-58 195.8 0.1 2.1 2 0 0 2 2 2 1 FtsJ-like methyltransferase Spb1_C PF07780.12 EEA08605.1 - 3.7e-44 150.9 24.9 3.7e-44 150.9 24.9 2.9 3 1 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.8 EEA08605.1 - 8.8e-27 93.9 13.3 8.8e-27 93.9 13.3 5.8 3 2 2 5 5 5 1 Domain of unknown function (DUF3381) Tma16 PF11176.8 EEA08606.1 - 0.14 12.0 0.2 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 Translation machinery-associated protein 16 Bclx_interact PF08945.10 EEA08608.1 - 0.019 14.8 23.3 1.7 8.5 0.2 5.8 5 1 1 6 6 6 0 Bcl-x interacting, BH3 domain Dicty_REP PF05086.12 EEA08608.1 - 1.8 6.4 14.1 2.5 6.0 14.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2016 PF09436.10 EEA08609.1 - 4.6e-06 26.3 0.1 24 4.8 0.0 5.0 4 0 0 4 4 4 0 Domain of unknown function (DUF2016) DUF5496 PF17600.2 EEA08609.1 - 7.7e-06 25.9 3.0 20 5.3 0.0 5.3 4 0 0 4 4 4 4 Family of unknown function (DUF5496) Pallilysin PF18663.1 EEA08609.1 - 0.0053 16.7 1.5 1.1e+02 2.8 0.0 4.7 4 0 0 4 4 4 0 Pallilysin beta barrel domain Nyv1_N PF09426.10 EEA08609.1 - 0.021 14.8 3.9 28 4.7 0.0 4.0 4 0 0 4 4 4 0 Vacuolar R-SNARE Nyv1 N terminal DUF493 PF04359.14 EEA08609.1 - 0.022 15.3 7.6 19 5.9 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF493) PP2C_2 PF13672.6 EEA08609.1 - 0.029 14.0 0.0 55 3.3 0.0 3.9 4 0 0 4 4 4 0 Protein phosphatase 2C Imm58 PF15581.6 EEA08609.1 - 0.032 14.3 2.8 67 3.7 0.0 4.0 4 0 0 4 4 4 0 Immunity protein 58 DUF5461 PF17545.2 EEA08609.1 - 0.14 12.5 0.1 2.1e+02 2.3 0.0 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5461) Pik1 PF11522.8 EEA08609.1 - 2 8.5 10.6 35 4.5 0.1 4.0 4 0 0 4 4 4 0 Yeast phosphatidylinositol-4-OH kinase Pik1 SKA2 PF16740.5 EEA08611.1 - 3.6e-05 23.5 0.6 0.15 11.9 0.1 2.1 2 0 0 2 2 2 2 Spindle and kinetochore-associated protein 2 Seryl_tRNA_N PF02403.22 EEA08611.1 - 0.00036 20.7 2.6 0.067 13.4 0.6 2.1 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF4200 PF13863.6 EEA08611.1 - 0.00059 20.2 2.6 0.07 13.5 1.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) DUF2353 PF09789.9 EEA08611.1 - 0.00073 19.0 1.6 0.00086 18.8 1.6 1.0 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) FliJ PF02050.16 EEA08611.1 - 0.0016 18.7 0.4 0.0021 18.3 0.4 1.1 1 0 0 1 1 1 1 Flagellar FliJ protein TPR_MLP1_2 PF07926.12 EEA08611.1 - 0.0017 18.4 3.8 0.011 15.8 1.0 2.0 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EEA08611.1 - 0.0024 18.4 4.9 0.0032 18.0 4.9 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region LRRFIP PF09738.9 EEA08611.1 - 0.0034 16.9 1.0 0.13 11.8 0.3 2.0 2 0 0 2 2 2 1 LRRFIP family BLOC1_2 PF10046.9 EEA08611.1 - 0.0046 17.2 1.6 0.31 11.4 0.3 2.1 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4446 PF14584.6 EEA08611.1 - 0.0049 16.9 0.8 0.65 10.0 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4446) AAA_13 PF13166.6 EEA08611.1 - 0.0056 15.4 0.1 0.0066 15.2 0.1 1.1 1 0 0 1 1 1 1 AAA domain DUF4618 PF15397.6 EEA08611.1 - 0.0057 16.1 1.8 0.049 13.0 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4618) Sec2p PF06428.11 EEA08611.1 - 0.006 16.5 3.1 0.021 14.8 0.4 2.0 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF4140 PF13600.6 EEA08611.1 - 0.0062 17.0 0.6 0.66 10.5 0.3 2.1 2 0 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) ABC_tran_CTD PF16326.5 EEA08611.1 - 0.0069 16.6 4.5 0.31 11.3 1.1 2.2 2 0 0 2 2 2 1 ABC transporter C-terminal domain Med9 PF07544.13 EEA08611.1 - 0.0087 16.1 1.2 0.54 10.4 0.1 2.2 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 FlxA PF14282.6 EEA08611.1 - 0.0088 16.0 2.5 0.28 11.2 0.6 2.1 2 0 0 2 2 2 1 FlxA-like protein ZapB PF06005.12 EEA08611.1 - 0.011 16.1 5.0 0.59 10.6 2.3 2.1 2 0 0 2 2 2 0 Cell division protein ZapB YojJ PF10372.9 EEA08611.1 - 0.011 15.8 1.1 0.22 11.6 0.2 2.1 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus TSC22 PF01166.18 EEA08611.1 - 0.012 15.9 4.9 1.8 8.9 0.4 2.4 2 1 0 2 2 2 0 TSC-22/dip/bun family TMF_DNA_bd PF12329.8 EEA08611.1 - 0.012 15.5 9.6 0.36 10.8 3.1 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Csm1_N PF18504.1 EEA08611.1 - 0.013 15.9 6.6 0.24 11.8 1.9 2.1 2 0 0 2 2 2 0 Csm1 N-terminal domain Vps51 PF08700.11 EEA08611.1 - 0.015 15.3 1.1 0.12 12.4 0.3 2.1 2 0 0 2 2 2 0 Vps51/Vps67 Atg14 PF10186.9 EEA08611.1 - 0.017 14.3 1.7 0.022 13.9 1.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4349 PF14257.6 EEA08611.1 - 0.017 14.5 0.5 0.043 13.3 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) SlyX PF04102.12 EEA08611.1 - 0.019 15.5 2.8 0.24 12.0 0.3 2.2 2 0 0 2 2 2 0 SlyX Cep57_MT_bd PF06657.13 EEA08611.1 - 0.02 15.3 1.0 0.19 12.2 0.1 2.0 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 FlaC_arch PF05377.11 EEA08611.1 - 0.02 15.3 2.9 0.11 12.9 0.4 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CHASE3 PF05227.13 EEA08611.1 - 0.031 14.2 0.2 0.065 13.1 0.2 1.5 1 1 0 1 1 1 0 CHASE3 domain Syntaxin PF00804.25 EEA08611.1 - 0.034 13.8 0.9 0.21 11.3 0.1 1.9 2 0 0 2 2 2 0 Syntaxin FapA PF03961.13 EEA08611.1 - 0.035 12.7 4.2 0.065 11.8 4.3 1.2 1 1 0 1 1 1 0 Flagellar Assembly Protein A THOC7 PF05615.13 EEA08611.1 - 0.036 14.4 4.5 0.24 11.7 1.8 2.0 2 0 0 2 2 2 0 Tho complex subunit 7 PHM7_cyt PF14703.6 EEA08611.1 - 0.04 14.2 0.7 0.054 13.7 0.7 1.3 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter BST2 PF16716.5 EEA08611.1 - 0.042 14.4 5.0 3.7 8.2 0.2 2.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 HemX PF04375.14 EEA08611.1 - 0.043 13.1 0.1 0.055 12.8 0.1 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Prefoldin_2 PF01920.20 EEA08611.1 - 0.044 13.8 8.5 0.14 12.1 2.8 2.1 2 0 0 2 2 2 0 Prefoldin subunit YabA PF06156.13 EEA08611.1 - 0.05 14.2 0.9 1.2 9.8 0.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA HMMR_C PF15908.5 EEA08611.1 - 0.05 13.9 3.1 0.11 12.8 1.4 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal WXG100 PF06013.12 EEA08611.1 - 0.052 13.8 0.1 0.29 11.4 0.0 1.9 1 1 1 2 2 2 0 Proteins of 100 residues with WXG EzrA PF06160.12 EEA08611.1 - 0.053 11.7 4.5 0.23 9.6 4.5 1.7 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA DivIC PF04977.15 EEA08611.1 - 0.058 13.2 5.0 0.34 10.7 1.2 2.2 2 0 0 2 2 2 0 Septum formation initiator XhlA PF10779.9 EEA08611.1 - 0.059 13.6 7.9 1.8 8.9 0.9 2.6 3 0 0 3 3 2 0 Haemolysin XhlA V_ATPase_I PF01496.19 EEA08611.1 - 0.061 11.2 0.1 0.071 11.0 0.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5082 PF16888.5 EEA08611.1 - 0.062 13.6 4.3 0.24 11.7 4.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Nup54 PF13874.6 EEA08611.1 - 0.07 13.2 1.5 0.42 10.7 0.4 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 SLATT_fungal PF18142.1 EEA08611.1 - 0.085 12.8 0.3 0.3 11.1 0.2 1.8 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain TolA_bind_tri PF16331.5 EEA08611.1 - 0.094 12.8 2.6 0.14 12.3 0.6 1.8 2 0 0 2 2 2 0 TolA binding protein trimerisation NPV_P10 PF05531.12 EEA08611.1 - 0.099 13.1 0.0 0.32 11.5 0.0 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Swi5 PF07061.11 EEA08611.1 - 0.1 12.7 4.5 0.69 10.0 1.1 2.1 2 0 0 2 2 2 0 Swi5 Uso1_p115_C PF04871.13 EEA08611.1 - 0.1 13.0 5.1 0.23 11.8 5.1 1.5 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CdvA PF18822.1 EEA08611.1 - 0.11 12.4 5.1 0.69 9.7 0.7 2.2 2 0 0 2 2 2 0 CdvA-like coiled-coil domain DUF5339 PF17274.2 EEA08611.1 - 0.12 13.2 0.6 0.12 13.2 0.6 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5339) DUF4315 PF14193.6 EEA08611.1 - 0.13 12.3 9.1 1.7 8.7 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) Prefoldin PF02996.17 EEA08611.1 - 0.15 12.0 7.4 0.35 10.8 2.4 2.1 2 0 0 2 2 2 0 Prefoldin subunit YtxH PF12732.7 EEA08611.1 - 0.17 12.5 1.0 6.8 7.3 0.4 2.2 2 0 0 2 2 2 0 YtxH-like protein HalX PF08663.10 EEA08611.1 - 0.17 12.2 1.9 1.3 9.4 0.2 2.1 2 0 0 2 2 2 0 HalX domain WHEP-TRS PF00458.20 EEA08611.1 - 0.17 12.0 0.6 0.17 12.0 0.6 2.0 2 0 0 2 2 2 0 WHEP-TRS domain DUF724 PF05266.14 EEA08611.1 - 0.22 11.3 3.2 0.36 10.6 3.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF724) HR1 PF02185.16 EEA08611.1 - 0.32 11.1 9.5 0.44 10.7 2.2 2.2 2 0 0 2 2 2 0 Hr1 repeat Rop-like PF05082.13 EEA08611.1 - 0.34 10.7 0.2 0.34 10.7 0.2 2.1 2 0 0 2 2 2 0 Rop-like Spc7 PF08317.11 EEA08611.1 - 0.41 9.5 7.5 1.5 7.6 7.5 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Erp_C PF06780.11 EEA08611.1 - 0.5 10.4 3.6 1.4 8.9 3.4 1.7 1 1 1 2 2 2 0 Erp protein C-terminus Spc24 PF08286.11 EEA08611.1 - 0.58 10.4 8.2 0.43 10.9 3.0 2.1 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 DUF1192 PF06698.11 EEA08611.1 - 1 9.5 5.4 5.7 7.1 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) GrpE PF01025.19 EEA08611.1 - 1.1 8.9 6.6 26 4.4 7.5 2.0 1 1 0 1 1 1 0 GrpE GAS PF13851.6 EEA08611.1 - 1.1 8.6 11.7 12 5.2 11.7 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIVA PF05103.13 EEA08611.1 - 1.2 9.2 6.5 3 7.9 0.6 2.4 3 0 0 3 3 2 0 DivIVA protein DUF1319 PF07028.11 EEA08611.1 - 1.7 8.9 5.6 32 4.8 5.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) TraC PF07820.12 EEA08611.1 - 1.9 8.9 6.1 1.8 9.0 1.3 2.1 2 0 0 2 2 2 0 TraC-like protein JIP_LZII PF16471.5 EEA08611.1 - 2.8 8.2 8.5 7.1 6.9 2.4 2.1 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Peptidase_M16 PF00675.20 EEA08612.1 - 2.6e-36 124.8 0.0 7.8e-36 123.3 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EEA08612.1 - 3e-23 82.5 11.6 3.9e-18 65.8 6.5 2.6 2 0 0 2 2 2 2 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EEA08612.1 - 2.6e-19 70.0 3.1 4.7e-15 56.1 0.3 3.2 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M4 PF01447.18 EEA08612.1 - 0.23 11.9 1.2 0.55 10.7 0.0 2.2 2 0 0 2 2 2 0 Thermolysin metallopeptidase, catalytic domain Sugar_tr PF00083.24 EEA08613.1 - 1e-10 41.1 3.2 1.3e-10 40.8 3.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EEA08613.1 - 0.0025 16.8 6.2 0.0028 16.7 6.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2583 PF10762.9 EEA08613.1 - 0.091 13.2 1.0 0.11 12.9 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) 5TM-5TMR_LYT PF07694.12 EEA08613.1 - 0.1 12.1 8.3 0.12 11.9 8.3 1.0 1 0 0 1 1 1 0 5TMR of 5TMR-LYT DUF5337 PF17272.2 EEA08613.1 - 0.48 10.3 3.2 0.88 9.4 0.6 2.3 1 1 2 3 3 3 0 Family of unknown function (DUF5337) ROK PF00480.20 EEA08614.1 - 5e-10 39.3 0.0 6.4e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 ROK family MarR PF01047.22 EEA08614.1 - 2.9e-05 23.9 0.1 5.8e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 EEA08614.1 - 0.00032 20.5 0.2 0.00077 19.3 0.2 1.6 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 EEA08614.1 - 0.0013 18.7 0.1 0.0025 17.7 0.1 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 EEA08614.1 - 0.034 13.7 0.1 0.072 12.7 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_CodY PF08222.11 EEA08614.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain Peptidase_M75 PF09375.10 EEA08616.1 - 0.0099 15.4 1.4 0.012 15.1 1.4 1.1 1 0 0 1 1 1 1 Imelysin Peptidase_C23 PF05379.11 EEA08616.1 - 0.028 14.6 2.9 1.7 8.8 0.1 2.9 2 1 1 3 3 3 0 Carlavirus endopeptidase NPV_P10 PF05531.12 EEA08616.1 - 0.033 14.6 0.5 1 9.9 0.0 2.7 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein TBCC_N PF16752.5 EEA08616.1 - 0.051 14.0 0.3 13 6.2 0.0 2.7 2 1 1 3 3 3 0 Tubulin-specific chaperone C N-terminal domain ACP_syn_III PF08545.10 EEA08617.1 - 0.06 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FBPase_3 PF01950.16 EEA08618.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Fructose-1,6-bisphosphatase Myb_DNA-binding PF00249.31 EEA08619.1 - 0.0017 18.5 0.3 0.0036 17.5 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EEA08619.1 - 0.056 13.8 0.7 0.056 13.8 0.7 2.2 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Mu-like_Com PF10122.9 EEA08619.1 - 0.072 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Mu-like prophage protein Com TFB6 PF17110.5 EEA08619.1 - 0.3 10.8 4.3 9.5 5.9 0.1 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH UCH PF00443.29 EEA08620.1 - 2.6e-19 69.7 0.1 3.3e-19 69.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EEA08620.1 - 0.00081 19.1 0.4 0.0017 18.1 0.4 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase IGFL PF14653.6 EEA08620.1 - 0.058 13.4 0.1 0.14 12.2 0.0 1.6 2 0 0 2 2 2 0 Insulin growth factor-like family DUF4140 PF13600.6 EEA08621.1 - 0.073 13.5 0.0 0.27 11.7 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) His_Phos_1 PF00300.22 EEA08622.1 - 6.8e-15 55.3 2.0 1.2e-14 54.5 2.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF4364 PF14277.6 EEA08622.1 - 0.078 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) PadR PF03551.14 EEA08622.1 - 0.099 12.6 0.3 0.17 11.9 0.3 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family ABC_tran_CTD PF16326.5 EEA08624.1 - 0.044 14.0 4.1 1 9.6 0.1 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain Cob_adeno_trans PF01923.18 EEA08624.1 - 0.11 12.7 0.1 0.13 12.4 0.1 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase UPF0242 PF06785.11 EEA08624.1 - 0.44 10.6 9.9 0.28 11.2 2.4 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SASA PF03629.18 EEA08625.1 - 4.5e-17 62.5 1.2 4.1e-13 49.5 0.0 2.5 3 0 0 3 3 3 2 Carbohydrate esterase, sialic acid-specific acetylesterase Glyco_hydro_2_N PF02837.18 EEA08625.1 - 1.5e-05 24.9 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Fip1 PF05182.13 EEA08629.1 - 2e-09 36.8 0.0 3.3e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Fip1 motif # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_muris-RN66-JCVI-cmg-v1.0/GCA_000006515.1_JCVI_cmg_v1.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_muris-RN66-JCVI-cmg-v1.0/GCA_000006515.1_JCVI_cmg_v1.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_muris-RN66-JCVI-cmg-v1.0/GCA_000006515.1_JCVI_cmg_v1.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Apicomplexa/Cryptosporidium_muris-RN66-JCVI-cmg-v1.0/GCA_000006515.1_JCVI_cmg_v1.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 00:27:42 2019 # [ok]